id	subject	predicate	object	category	primary_knowledge_source	knowledge_level	agent_type	source_records	description	evidence	reference_metadata	endpoint_qualifiers
pathwaymech:MetaCyc_PWY-5901_dhb-edge-001_4cb1a2d5f705	CHEBI:29748	pathwaymech:consumes	RHEA:18986	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18986		"[{""reference_id"": ""RHEA:18986"", ""source_assertion"": ""RHEA:18986 assigns CHEBI:29748 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/18986 rh:substrates; http://rdf.rhea-db.org/18985_L rh:contains1 http://rdf.rhea-db.org/Participant_18985_compound_3304; http://rdf.rhea-db.org/Participant_18985_compound_3304 rh:compound http://rdf.rhea-db.org/Compound_3304; rh:chebi""}]"	"[{""id"": ""RHEA:18986"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 18986"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-002_043b9d36c8b1	RHEA:18986	pathwaymech:produces	CHEBI:29780	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18986		"[{""reference_id"": ""RHEA:18986"", ""source_assertion"": ""RHEA:18986 assigns CHEBI:29780 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/18986 rh:products; http://rdf.rhea-db.org/18985_R rh:contains1 http://rdf.rhea-db.org/Participant_18985_compound_3577; http://rdf.rhea-db.org/Participant_18985_compound_3577 rh:compound http://rdf.rhea-db.org/Compound_3577; rh:chebi""}]"	"[{""id"": ""RHEA:18986"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 18986"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-003_f2b0807a7faf	CHEBI:29780	pathwaymech:consumes	RHEA:11113	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11113		"[{""reference_id"": ""RHEA:11113"", ""source_assertion"": ""RHEA:11113 assigns CHEBI:29780 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/11113 rh:substrates; http://rdf.rhea-db.org/11112_L rh:contains1 http://rdf.rhea-db.org/Participant_11112_compound_3577; http://rdf.rhea-db.org/Participant_11112_compound_3577 rh:compound http://rdf.rhea-db.org/Compound_3577; rh:chebi""}]"	"[{""id"": ""RHEA:11113"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 11113"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-004_66541bf2f1ca	CHEBI:15377	pathwaymech:consumes	RHEA:11113	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11113		"[{""reference_id"": ""RHEA:11113"", ""source_assertion"": ""RHEA:11113 assigns CHEBI:15377 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/11113 rh:substrates; http://rdf.rhea-db.org/11112_L rh:contains1 http://rdf.rhea-db.org/Participant_11112_compound_1283; http://rdf.rhea-db.org/Participant_11112_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; rh:chebi""}]"	"[{""id"": ""RHEA:11113"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 11113"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-005_fe087198515c	RHEA:11113	pathwaymech:produces	CHEBI:58764	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11113		"[{""reference_id"": ""RHEA:11113"", ""source_assertion"": ""RHEA:11113 assigns CHEBI:58764 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/11113 rh:products; http://rdf.rhea-db.org/11112_R rh:contains1 http://rdf.rhea-db.org/Participant_11112_compound_5459; http://rdf.rhea-db.org/Participant_11112_compound_5459 rh:compound http://rdf.rhea-db.org/Compound_5459; rh:chebi""}]"	"[{""id"": ""RHEA:11113"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 11113"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-006_fdef4ec4b707	RHEA:11113	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11113		"[{""reference_id"": ""RHEA:11113"", ""source_assertion"": ""RHEA:11113 assigns CHEBI:15361 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/11113 rh:products; http://rdf.rhea-db.org/11112_R rh:contains1 http://rdf.rhea-db.org/Participant_11112_compound_3719; http://rdf.rhea-db.org/Participant_11112_compound_3719 rh:compound http://rdf.rhea-db.org/Compound_3719; rh:chebi""}]"	"[{""id"": ""RHEA:11113"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 11113"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-007_e9cd2198187d	CHEBI:58764	pathwaymech:consumes	RHEA:23825	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23825		"[{""reference_id"": ""RHEA:23825"", ""source_assertion"": ""RHEA:23825 assigns CHEBI:58764 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/23825 rh:substrates; http://rdf.rhea-db.org/23824_L rh:contains1 http://rdf.rhea-db.org/Participant_23824_compound_5459; http://rdf.rhea-db.org/Participant_23824_compound_5459 rh:compound http://rdf.rhea-db.org/Compound_5459; rh:chebi""}]"	"[{""id"": ""RHEA:23825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 23825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-008_5da9d2e58667	CHEBI:57540	pathwaymech:consumes	RHEA:23825	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23825		"[{""reference_id"": ""RHEA:23825"", ""source_assertion"": ""RHEA:23825 assigns CHEBI:57540 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/23825 rh:substrates; http://rdf.rhea-db.org/23824_L rh:contains1 http://rdf.rhea-db.org/Participant_23824_compound_3484; http://rdf.rhea-db.org/Participant_23824_compound_3484 rh:compound http://rdf.rhea-db.org/Compound_3484; rh:chebi""}]"	"[{""id"": ""RHEA:23825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 23825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-009_0cf0936a5809	RHEA:23825	pathwaymech:produces	CHEBI:36654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23825		"[{""reference_id"": ""RHEA:23825"", ""source_assertion"": ""RHEA:23825 assigns CHEBI:36654 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/23825 rh:products; http://rdf.rhea-db.org/23824_R rh:contains1 http://rdf.rhea-db.org/Participant_23824_compound_3751; http://rdf.rhea-db.org/Participant_23824_compound_3751 rh:compound http://rdf.rhea-db.org/Compound_3751; rh:chebi""}]"	"[{""id"": ""RHEA:23825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 23825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-010_4b3b019ed8f8	RHEA:23825	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23825		"[{""reference_id"": ""RHEA:23825"", ""source_assertion"": ""RHEA:23825 assigns CHEBI:57945 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/23825 rh:products; http://rdf.rhea-db.org/23824_R rh:contains1 http://rdf.rhea-db.org/Participant_23824_compound_1650; http://rdf.rhea-db.org/Participant_23824_compound_1650 rh:compound http://rdf.rhea-db.org/Compound_1650; rh:chebi""}]"	"[{""id"": ""RHEA:23825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 23825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-011_a08cfa33afc8	RHEA:23825	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23825		"[{""reference_id"": ""RHEA:23825"", ""source_assertion"": ""RHEA:23825 assigns CHEBI:15378 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/23825 rh:products; http://rdf.rhea-db.org/23824_R rh:contains1 http://rdf.rhea-db.org/Participant_23824_compound_3249; http://rdf.rhea-db.org/Participant_23824_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:23825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 23825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-012_69cb1d7b3997	UniProtKB:P0AEJ2	pathwaymech:catalyzes	RHEA:18986	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENTC-MONOMER|PMID:2139795|RHEA:18986|UniProtKB:P0AEJ2	The selected forward reaction supplies isochorismate to DHB synthesis. EntC is reversible; this direction is not a claim of irreversible chemistry. Purified EntC itself is active, so the protein node has direct catalytic support.	"[{""reference_id"": ""UniProtKB:P0AEJ2"", ""source_assertion"": ""Reviewed K-12 EntC assigns chorismate/isochorismate interconversion to RHEA:18985 with ECO:0000269 citations 17243787, 20079748 and 2139795; SUBUNIT specifies monomer."", ""source_locator"": ""/organism/taxonId; /comments/1/reaction; /comments/5""}, {""reference_id"": ""MetaCyc:ENTC-MONOMER"", ""source_assertion"": ""ENTC-MONOMER catalyzes ISOCHORSYN-RXN through ENTC-ENZRXN and explicitly unifies UniProt P0AEJ2."", ""source_locator"": ""Protein[@frameid=\""ENTC-MONOMER\""]/catalyzes/Enzymatic-Reaction[@frameid=\""ENTC-ENZRXN\""]/reaction; dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""PMID:2139795"", ""source_assertion"": ""Purified E. coli EntC is an active monomer and alone catalyzes reversible chorismate/isochorismate interconversion; EntA does not alter that activity. The measured equilibrium favors chorismate."", ""source_locator"": ""/resultList/result[id=\""2139795\""]/abstractText""}, {""reference_id"": ""RHEA:18986"", ""source_assertion"": ""Master RHEA:18985 explicitly links directionalReaction RHEA:18986."", ""source_locator"": ""http://rdf.rhea-db.org/18985 rh:directionalReaction http://rdf.rhea-db.org/18986""}]"	"[{""id"": ""MetaCyc:ENTC-MONOMER"", ""source_sha256"": ""52e0e6b20a111e2a648b47d8fe063fcd038a2de1553138bfdacba1d561836e91"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc ENTC-MONOMER: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENTC-MONOMER""}, {""id"": ""PMID:2139795"", ""source_sha256"": ""85cfb55849c394ca17e80f980e7285886619c6f65f820e3d6d374ef9d079b46f"", ""source_version"": ""1990; indexed abstract in retained Europe PMC core JSON, not full article"", ""title"": ""Overexpression, purification, and characterization of isochorismate synthase (EntC), the first enzyme involved in the biosynthesis of enterobactin from chorismate."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/2139795/""}, {""id"": ""RHEA:18986"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 18986"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0AEJ2"", ""source_sha256"": ""15c91f10c971c01fd6293782a86575c7f4543ea292b9bc741ec7f35ef8b9a4b6"", ""source_version"": ""Reviewed UniProt 2026_03; complete JSON retrieved 2026-10-11 UTC"", ""title"": ""Isochorismate synthase EntC"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AEJ2.json""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-013_fe803f92f921	MetaCyc:ENTB-CPLX	pathwaymech:catalyzes	RHEA:11113	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENTB-CPLX|PMID:2139796|RHEA:11113|UniProtKB:P0ADI4	The catalyst is the exact source-defined holo-EntB dimer. This retains a supported active form without asserting that phosphopantetheinylation of the separate carrier domain is necessary for isochorismatase activity or that apo-EntB lacks that activity.	"[{""reference_id"": ""MetaCyc:ENTB-CPLX"", ""source_assertion"": ""The native holo-EntB dimer catalyzes ISOCHORMAT-RXN through ISOCHORMAT-ENZRXN. Its N-terminal domain is the isochorismatase; its C-terminal aryl carrier domain participates later in enterobactin assembly."", ""source_locator"": ""Protein[@frameid=\""ENTB-CPLX\""]/catalyzes/Enzymatic-Reaction[@frameid=\""ISOCHORMAT-ENZRXN\""]/reaction; comment""}, {""reference_id"": ""UniProtKB:P0ADI4"", ""source_assertion"": ""K-12 EntB CATALYTIC ACTIVITY assigns RHEA:11112, isochorismate plus water to the (2S,3S) dihydroxy-dihydrobenzoate and pyruvate, with ECO:0000269 citations 16632253, 2139796, 9214294 and 9485415."", ""source_locator"": ""/organism/taxonId; /comments/2/reaction""}, {""reference_id"": ""PMID:2139796"", ""source_assertion"": ""Purified recombinant EntB catalyzes the isochorismate reaction; proton NMR followed the expected dihydro-dihydroxybenzoate product. This experiment assigns the protein activity, not a requirement for carrier-domain phosphopantetheinylation."", ""source_locator"": ""/resultList/result[id=\""2139796\""]/abstractText""}, {""reference_id"": ""RHEA:11113"", ""source_assertion"": ""Master RHEA:11112 explicitly links directionalReaction RHEA:11113."", ""source_locator"": ""http://rdf.rhea-db.org/11112 rh:directionalReaction http://rdf.rhea-db.org/11113""}]"	"[{""id"": ""MetaCyc:ENTB-CPLX"", ""source_sha256"": ""6de80c7a21186f5fd510252cbecf992748d13d421b996ff0b1169118b71f43d0"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc ENTB-CPLX: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENTB-CPLX""}, {""id"": ""PMID:2139796"", ""source_sha256"": ""715986c5918c80d590e79f0aac6c3f149d81bfbd791994232b410fc2e3312965"", ""source_version"": ""1990; indexed abstract in retained Europe PMC core JSON, not full article"", ""title"": ""Subcloning of the enterobactin biosynthetic gene entB: expression, purification, characterization, and substrate specificity of isochorismatase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/2139796/""}, {""id"": ""RHEA:11113"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 11113"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0ADI4"", ""source_sha256"": ""4bb0083a3305cf700583822edbc55244ac3ade3cf47b49847ee10495dd8464d1"", ""source_version"": ""Reviewed UniProt 2026_03; complete JSON retrieved 2026-10-11 UTC"", ""title"": ""Enterobactin synthase component B"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ADI4.json""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-014_dec48a436cba	MetaCyc:ENTA-CPLX	pathwaymech:catalyzes	RHEA:23825	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENTA-CPLX|PMID:2144454|RHEA:23825|UniProtKB:P15047	One net reaction includes the subsequent rapid aromatization; a separate aromatization edge would double count the selected net chemistry. NAD is a consumed redox cosubstrate, not an additional bound-cofactor claim.	"[{""reference_id"": ""MetaCyc:ENTA-CPLX"", ""source_assertion"": ""ENTA-CPLX catalyzes DHBDEHYD-RXN through DHBDEHYD-ENZRXN; its comment distinguishes C3 oxidation and rapid aromatization from the net DHB-forming reaction."", ""source_locator"": ""Protein[@frameid=\""ENTA-CPLX\""]/catalyzes/Enzymatic-Reaction[@frameid=\""DHBDEHYD-ENZRXN\""]/reaction; comment""}, {""reference_id"": ""UniProtKB:P15047"", ""source_assertion"": ""K-12 EntA CATALYTIC ACTIVITY assigns RHEA:23824 and the exact (2S,3S) dihydroxy-dihydrobenzoate/NAD reaction with ECO:0000269 PMID:2144454."", ""source_locator"": ""/organism/taxonId; /comments/1/reaction""}, {""reference_id"": ""PMID:2144454"", ""source_assertion"": ""EntA oxidizes the C3 hydroxyl with NAD; the transient keto intermediate aromatizes to DHB. Reversibility was demonstrated with substrate analogues, not by demonstrating physiological reduction of aromatic DHB."", ""source_locator"": ""/resultList/result[id=\""2144454\""]/abstractText""}, {""reference_id"": ""RHEA:23825"", ""source_assertion"": ""Master RHEA:23824 explicitly links directionalReaction RHEA:23825."", ""source_locator"": ""http://rdf.rhea-db.org/23824 rh:directionalReaction http://rdf.rhea-db.org/23825""}]"	"[{""id"": ""MetaCyc:ENTA-CPLX"", ""source_sha256"": ""94bfacaa03b3f3339833839470b382fdc28f7384fa92b70fcc535d1c18e6de88"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc ENTA-CPLX: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENTA-CPLX""}, {""id"": ""PMID:2144454"", ""source_sha256"": ""04794f0f8e2ce8236604656840bf1503f51f3d4a10341098cc19029e9991c21e"", ""source_version"": ""1990; indexed abstract in retained Europe PMC core JSON, not full article"", ""title"": ""Mechanistic studies on trans-2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (Ent A) in the biosynthesis of the iron chelator enterobactin."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/2144454/""}, {""id"": ""RHEA:23825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 23825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P15047"", ""source_sha256"": ""b00850662da8517045c70ff9519dd5411795a6da50549184d13067eec86211a1"", ""source_version"": ""Reviewed UniProt 2026_03; complete JSON retrieved 2026-10-11 UTC"", ""title"": ""2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P15047.json""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-015_bf96ade528b0	UniProtKB:P15047	BFO:0000050	MetaCyc:ENTA-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENTA-CPLX|MetaCyc:ENTA-MONOMER|PMID:21166461|PMID:2521622|UniProtKB:P15047	Four EntA subunits define the selected native complex. The record does not claim that the tetramer is the only populated or catalytically competent state. PathBank preserves an older eight-subunit interpretation that is not imported as the selected assembly.	"[{""reference_id"": ""MetaCyc:ENTA-CPLX"", ""source_assertion"": ""The native assembly contains four ENTA-MONOMER components. Its comment preserves the older gel-filtration octamer estimate, tetrameric crystal structure and later concentration-dependent dimer-to-tetramer transition."", ""source_locator"": ""Protein[@frameid=\""ENTA-CPLX\""]/component/Protein; component/coefficient; comment""}, {""reference_id"": ""MetaCyc:ENTA-MONOMER"", ""source_assertion"": ""ENTA-MONOMER explicitly unifies UniProt P15047 and has native MG1655 taxonomic provenance."", ""source_locator"": ""Protein[@frameid=\""ENTA-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]; species/Organism""}, {""reference_id"": ""UniProtKB:P15047"", ""source_assertion"": ""SUBUNIT annotates a homotetramer, a dimer of dimers, with ECO:0000269 citations 16790929, 21166461 and 2521622."", ""source_locator"": ""/comments/5""}, {""reference_id"": ""PMID:21166461"", ""source_assertion"": ""Analytical ultracentrifugation shows concentration-dependent EntA dimer-tetramer self-association, with a reported dissociation constant of 12.3 micromolar; this is not evidence that only one assembly exists."", ""source_locator"": ""/resultList/result[id=\""21166461\""]/abstractText""}, {""reference_id"": ""PMID:2521622"", ""source_assertion"": ""The 1989 purified preparation migrated at an estimated native mass of 210,000 on Superose 12, interpreted as an octamer. This historical estimate is retained as a conflicting assembly result."", ""source_locator"": ""PMC209666 full PDF p.795, Results/Purification of diDHB-DH; p.796 Discussion""}]"	"[{""id"": ""MetaCyc:ENTA-CPLX"", ""source_sha256"": ""94bfacaa03b3f3339833839470b382fdc28f7384fa92b70fcc535d1c18e6de88"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc ENTA-CPLX: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENTA-CPLX""}, {""id"": ""MetaCyc:ENTA-MONOMER"", ""source_sha256"": ""c7ef86c457fb2f332f054fcc6866e36f8b9ef591804d1ac6d302f1bdb608dfa2"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc ENTA-MONOMER: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENTA-MONOMER""}, {""id"": ""PMID:21166461"", ""source_sha256"": ""201f74cd1a680d18b48e939605ab3dbb7bd557e449079f558c59242da32d59a4"", ""source_version"": ""2011; indexed abstract in retained Europe PMC core JSON, not full article"", ""title"": ""Enzymatic adenylation of 2,3-dihydroxybenzoate is enhanced by a protein-protein interaction between Escherichia coli 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (EntA) and 2,3-dihydroxybenzoate-AMP ligase (EntE)."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/21166461/""}, {""id"": ""PMID:2521622"", ""source_sha256"": ""7202c514814dfe9e67fc5838273b600f8479a0e43d7588f3313f7591e9d1a19f"", ""source_version"": ""1989; complete scanned primary PDF, independently extracted and rendered; retrieved 2026-10-11 UTC"", ""title"": ""Nucleotide sequence of a cluster of Escherichia coli enterobactin biosynthesis genes: identification of entA and purification of its product 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase."", ""url"": ""https://europepmc.org/articles/PMC209666?pdf=render""}, {""id"": ""UniProtKB:P15047"", ""source_sha256"": ""b00850662da8517045c70ff9519dd5411795a6da50549184d13067eec86211a1"", ""source_version"": ""Reviewed UniProt 2026_03; complete JSON retrieved 2026-10-11 UTC"", ""title"": ""2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P15047.json""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-016_d64694965b87	MetaCyc:HOLO-ENTB	BFO:0000050	MetaCyc:ENTB-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENTB-CPLX|MetaCyc:ENTB-MONOMER|MetaCyc:HOLO-ENTB|UniProtKB:P0ADI4	Two modified EntB protein components are retained under their exact native state identifier. Their underlying sequence is P0ADI4. Carrier maturation and aryl loading belong to the surrounding enterobactin pathway and are not added as DHB-biosynthesis steps.	"[{""reference_id"": ""MetaCyc:ENTB-CPLX"", ""source_assertion"": ""ENTB-CPLX contains two HOLO-ENTB components. The comment identifies phosphopantetheinylated carrier-domain holo-EntB and records the modern dimer assignment versus earlier trimer/pentamer estimates."", ""source_locator"": ""Protein[@frameid=\""ENTB-CPLX\""]/component/Protein[@frameid=\""HOLO-ENTB\""]; component/coefficient; comment""}, {""reference_id"": ""MetaCyc:HOLO-ENTB"", ""source_assertion"": ""HOLO-ENTB explicitly names ENTB-MONOMER as its unmodified form and ENTB-CPLX as its containing assembly."", ""source_locator"": ""Protein[@frameid=\""HOLO-ENTB\""]/unmodified-form; component-of""}, {""reference_id"": ""MetaCyc:ENTB-MONOMER"", ""source_assertion"": ""The unmodified ENTB-MONOMER explicitly unifies UniProt P0ADI4. Its comment distinguishes the N-terminal isochorismatase from the C-terminal aryl carrier domain and EntD-dependent carrier maturation."", ""source_locator"": ""Protein[@frameid=\""ENTB-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]; comment""}, {""reference_id"": ""UniProtKB:P0ADI4"", ""source_assertion"": ""SUBUNIT specifies homodimer citing PMID:16632253 with ECO:0000269. Its wider EntB/EntD/EntE/EntF synthase association concerns downstream enterobactin assembly."", ""source_locator"": ""/comments/7""}]"	"[{""id"": ""MetaCyc:ENTB-CPLX"", ""source_sha256"": ""6de80c7a21186f5fd510252cbecf992748d13d421b996ff0b1169118b71f43d0"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc ENTB-CPLX: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENTB-CPLX""}, {""id"": ""MetaCyc:ENTB-MONOMER"", ""source_sha256"": ""7f8a62919119df6a3a2ccbf489ec3b88da45fd0941095e2cf7f0bdf52772d1b9"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc ENTB-MONOMER: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENTB-MONOMER""}, {""id"": ""MetaCyc:HOLO-ENTB"", ""source_sha256"": ""d362d5b6e979a61c48384ee743b5ae26be7d41b92644f49d51860530a622842e"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc HOLO-ENTB: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HOLO-ENTB""}, {""id"": ""UniProtKB:P0ADI4"", ""source_sha256"": ""4bb0083a3305cf700583822edbc55244ac3ade3cf47b49847ee10495dd8464d1"", ""source_version"": ""Reviewed UniProt 2026_03; complete JSON retrieved 2026-10-11 UTC"", ""title"": ""Enterobactin synthase component B"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ADI4.json""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-017_5ad4f99cc8f6	UniProtKB:P0AEJ2	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:20079748|UniProtKB:P0AEJ2	Magnesium binding is an explicit reviewed experimental annotation; it is not inferred merely from an assay containing magnesium.	"[{""reference_id"": ""UniProtKB:P0AEJ2"", ""source_assertion"": ""COFACTOR explicitly names Mg(2+), CHEBI:18420, and states two magnesium ions per subunit, with ECO:0000269 PMID:20079748."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}, {""reference_id"": ""PMID:20079748"", ""source_assertion"": ""The primary abstract reports an EntC structure in complex with isochorismate and Mg(2+) at 2.3 angstrom resolution. The two-ion count is sourced to the separate reviewed UniProt annotation, not this abstract."", ""source_locator"": ""/resultList/result[id=\""20079748\""]/abstractText""}]"	"[{""id"": ""PMID:20079748"", ""source_sha256"": ""939a0b488eb4c78e124c74398c41f137c95639cdba0fe85713a693d1f5ea1c58"", ""source_version"": ""2010; indexed abstract in retained Europe PMC core JSON, not full article"", ""title"": ""Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/20079748/""}, {""id"": ""UniProtKB:P0AEJ2"", ""source_sha256"": ""15c91f10c971c01fd6293782a86575c7f4543ea292b9bc741ec7f35ef8b9a4b6"", ""source_version"": ""Reviewed UniProt 2026_03; complete JSON retrieved 2026-10-11 UTC"", ""title"": ""Isochorismate synthase EntC"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AEJ2.json""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-018_d7d7d8bb4b1d	MetaCyc:ENTB-CPLX	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENTB-CPLX|MetaCyc:ENTB-MONOMER|MetaCyc:HOLO-ENTB|UniProtKB:P0ADI4	This is the reviewed EntB magnesium-cofactor annotation, retained at the source-defined dimer. The inspected primary abstract does not independently establish metal dependence or an occupancy count; crystallographic magnesium sites alone are not treated as a stoichiometric requirement.	"[{""reference_id"": ""UniProtKB:P0ADI4"", ""source_assertion"": ""COFACTOR explicitly names Mg(2+), CHEBI:18420, with ECO:0000269 PMID:16632253; no occupancy count is asserted by this annotation."", ""source_locator"": ""/comments/3/cofactors""}, {""reference_id"": ""MetaCyc:ENTB-CPLX"", ""source_assertion"": ""The source-defined EntB dimer is the isochorismatase catalyst; its two HOLO-ENTB components are the modified forms of the P0ADI4 gene product."", ""source_locator"": ""Protein[@frameid=\""ENTB-CPLX\""]/catalyzes/Enzymatic-Reaction[@frameid=\""ISOCHORMAT-ENZRXN\""]; component""}, {""reference_id"": ""MetaCyc:HOLO-ENTB"", ""source_assertion"": ""HOLO-ENTB explicitly links to unmodified ENTB-MONOMER."", ""source_locator"": ""Protein[@frameid=\""HOLO-ENTB\""]/unmodified-form""}, {""reference_id"": ""MetaCyc:ENTB-MONOMER"", ""source_assertion"": ""ENTB-MONOMER explicitly unifies UniProt P0ADI4."", ""source_locator"": ""Protein[@frameid=\""ENTB-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]""}]"	"[{""id"": ""MetaCyc:ENTB-CPLX"", ""source_sha256"": ""6de80c7a21186f5fd510252cbecf992748d13d421b996ff0b1169118b71f43d0"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc ENTB-CPLX: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENTB-CPLX""}, {""id"": ""MetaCyc:ENTB-MONOMER"", ""source_sha256"": ""7f8a62919119df6a3a2ccbf489ec3b88da45fd0941095e2cf7f0bdf52772d1b9"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc ENTB-MONOMER: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENTB-MONOMER""}, {""id"": ""MetaCyc:HOLO-ENTB"", ""source_sha256"": ""d362d5b6e979a61c48384ee743b5ae26be7d41b92644f49d51860530a622842e"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc HOLO-ENTB: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HOLO-ENTB""}, {""id"": ""UniProtKB:P0ADI4"", ""source_sha256"": ""4bb0083a3305cf700583822edbc55244ac3ade3cf47b49847ee10495dd8464d1"", ""source_version"": ""Reviewed UniProt 2026_03; complete JSON retrieved 2026-10-11 UTC"", ""title"": ""Enterobactin synthase component B"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ADI4.json""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-019_090f09f3cbce	RHEA:18986	BFO:0000050	MetaCyc:PWY-5901	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ISOCHORSYN-RXN|MetaCyc:PWY-5901|RHEA:18986		"[{""reference_id"": ""MetaCyc:PWY-5901"", ""source_assertion"": ""The complete native pathway explicitly lists ISOCHORSYN-RXN and orients it left-to-right in its pathway layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-5901\""]/reaction-list; reaction-layout""}, {""reference_id"": ""MetaCyc:ISOCHORSYN-RXN"", ""source_assertion"": ""ISOCHORSYN-RXN explicitly cross-references RHEA:18988; its native chemistry and pathway orientation identify the selected reaction."", ""source_locator"": ""Reaction[@frameid=\""ISOCHORSYN-RXN\""]/dblink[dblink-db=\""RHEA\""]; reaction-direction; left; right""}, {""reference_id"": ""RHEA:18986"", ""source_assertion"": ""Master RHEA:18985 links directionalReaction RHEA:18986 and bidirectionalReaction RHEA:18988; the native reversible reaction is projected in its pathway synthesis direction."", ""source_locator"": ""http://rdf.rhea-db.org/18985 rh:directionalReaction http://rdf.rhea-db.org/18986; rh:bidirectionalReaction http://rdf.rhea-db.org/18988""}]"	"[{""id"": ""MetaCyc:ISOCHORSYN-RXN"", ""source_sha256"": ""12b0f7a51414fd2dc6ea14d9596d9cc7f0fcc121d0843c434e3ae5b23af90198"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc ISOCHORSYN-RXN: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ISOCHORSYN-RXN""}, {""id"": ""MetaCyc:PWY-5901"", ""source_sha256"": ""2b978bba42064a27efcf351934b22c6c0fa9c335e1f24965cc70897daf22427c"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc PWY-5901: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5901""}, {""id"": ""RHEA:18986"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 18986"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-020_43640dfe867a	RHEA:11113	BFO:0000050	MetaCyc:PWY-5901	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ISOCHORMAT-RXN|MetaCyc:PWY-5901|RHEA:11113		"[{""reference_id"": ""MetaCyc:PWY-5901"", ""source_assertion"": ""The complete native pathway explicitly lists ISOCHORMAT-RXN and orients it left-to-right in its pathway layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-5901\""]/reaction-list; reaction-layout""}, {""reference_id"": ""MetaCyc:ISOCHORMAT-RXN"", ""source_assertion"": ""ISOCHORMAT-RXN explicitly cross-references RHEA:11112; its native chemistry and pathway orientation identify the selected reaction."", ""source_locator"": ""Reaction[@frameid=\""ISOCHORMAT-RXN\""]/dblink[dblink-db=\""RHEA\""]; reaction-direction; left; right""}, {""reference_id"": ""RHEA:11113"", ""source_assertion"": ""Master RHEA:11112 explicitly links directionalReaction RHEA:11113."", ""source_locator"": ""http://rdf.rhea-db.org/11112 rh:directionalReaction http://rdf.rhea-db.org/11113""}]"	"[{""id"": ""MetaCyc:ISOCHORMAT-RXN"", ""source_sha256"": ""17750d21f912eb41d92fa0e73773cf03caa447c64bcf1467fda491f69175c76c"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc ISOCHORMAT-RXN: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ISOCHORMAT-RXN""}, {""id"": ""MetaCyc:PWY-5901"", ""source_sha256"": ""2b978bba42064a27efcf351934b22c6c0fa9c335e1f24965cc70897daf22427c"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc PWY-5901: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5901""}, {""id"": ""RHEA:11113"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 11113"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-021_b2d7665e265f	RHEA:23825	BFO:0000050	MetaCyc:PWY-5901	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DHBDEHYD-RXN|MetaCyc:PWY-5901|RHEA:23825		"[{""reference_id"": ""MetaCyc:PWY-5901"", ""source_assertion"": ""The complete native pathway explicitly lists DHBDEHYD-RXN and orients it left-to-right in its pathway layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-5901\""]/reaction-list; reaction-layout""}, {""reference_id"": ""MetaCyc:DHBDEHYD-RXN"", ""source_assertion"": ""DHBDEHYD-RXN explicitly cross-references RHEA:23825; its native chemistry and pathway orientation identify the selected reaction."", ""source_locator"": ""Reaction[@frameid=\""DHBDEHYD-RXN\""]/dblink[dblink-db=\""RHEA\""]; reaction-direction; left; right""}, {""reference_id"": ""RHEA:23825"", ""source_assertion"": ""Master RHEA:23824 explicitly links directionalReaction RHEA:23825."", ""source_locator"": ""http://rdf.rhea-db.org/23824 rh:directionalReaction http://rdf.rhea-db.org/23825""}]"	"[{""id"": ""MetaCyc:DHBDEHYD-RXN"", ""source_sha256"": ""e694e624fe8f8d1690686a60f51bed77323eb276f5ccecf67ecc9860c83de4e0"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc DHBDEHYD-RXN: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHBDEHYD-RXN""}, {""id"": ""MetaCyc:PWY-5901"", ""source_sha256"": ""2b978bba42064a27efcf351934b22c6c0fa9c335e1f24965cc70897daf22427c"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc PWY-5901: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5901""}, {""id"": ""RHEA:23825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 23825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-022_f7fc6569ce9d	RHEA:18986	pathwaymech:precedes	RHEA:11113	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5901|PMID:4928016|RHEA:11113|RHEA:18986	Biochemical ordering through a shared small-molecule intermediate; no obligate channeling or stable multienzyme complex is asserted.	"[{""reference_id"": ""MetaCyc:PWY-5901"", ""source_assertion"": ""Native reaction ordering places ISOCHORSYN-RXN before ISOCHORMAT-RXN; the shared native intermediate connects the two complete transformations."", ""source_locator"": ""Pathway[@frameid=\""PWY-5901\""]/reaction-ordering""}, {""reference_id"": ""RHEA:18986"", ""source_assertion"": ""RHEA:18986 has CHEBI:29780 on its products side via its participant and compound objects."", ""source_locator"": ""http://rdf.rhea-db.org/18986 rh:products http://rdf.rhea-db.org/18985_R; http://rdf.rhea-db.org/18985_R rh:contains1 http://rdf.rhea-db.org/Participant_18985_compound_3577; rh:compound http://rdf.rhea-db.org/Compound_3577; rh:chebi""}, {""reference_id"": ""RHEA:11113"", ""source_assertion"": ""RHEA:11113 has CHEBI:29780 on its substrates side via its participant and compound objects."", ""source_locator"": ""http://rdf.rhea-db.org/11113 rh:substrates http://rdf.rhea-db.org/11112_L; http://rdf.rhea-db.org/11112_L rh:contains1 http://rdf.rhea-db.org/Participant_11112_compound_3577; rh:compound http://rdf.rhea-db.org/Compound_3577; rh:chebi""}, {""reference_id"": ""PMID:4928016"", ""source_assertion"": ""K-12 mutant extract complementation and intermediate accumulation resolve the EntC, EntB and EntA sequence from chorismate through isochorismate and dihydro-dihydroxybenzoate to DHB."", ""source_locator"": ""PMC248643 full PDF pp.54-55, Identification of enzyme deficiency; Tables 2 and 3""}]"	"[{""id"": ""MetaCyc:PWY-5901"", ""source_sha256"": ""2b978bba42064a27efcf351934b22c6c0fa9c335e1f24965cc70897daf22427c"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc PWY-5901: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5901""}, {""id"": ""PMID:4928016"", ""source_sha256"": ""297a466d033a1c5898897547cf390837d23aa3ff25b97cb32318b3c0bd8c7aae"", ""source_version"": ""1971; complete scanned primary PDF, independently extracted and rendered; retrieved 2026-10-11 UTC"", ""title"": ""Biosynthesis of the iron-transport compound enterochelin: mutants of Escherichia coli unable to synthesize 2,3-dihydroxybenzoate."", ""url"": ""https://europepmc.org/articles/PMC248643?pdf=render""}, {""id"": ""RHEA:11113"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 11113"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:18986"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 18986"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5901_dhb-edge-023_2756145c368f	RHEA:11113	pathwaymech:precedes	RHEA:23825	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5901|PMID:4928016|RHEA:11113|RHEA:23825	Biochemical ordering through a shared small-molecule intermediate; no obligate channeling or stable multienzyme complex is asserted.	"[{""reference_id"": ""MetaCyc:PWY-5901"", ""source_assertion"": ""Native reaction ordering places ISOCHORMAT-RXN before DHBDEHYD-RXN; the shared native intermediate connects the two complete transformations."", ""source_locator"": ""Pathway[@frameid=\""PWY-5901\""]/reaction-ordering""}, {""reference_id"": ""RHEA:11113"", ""source_assertion"": ""RHEA:11113 has CHEBI:58764 on its products side via its participant and compound objects."", ""source_locator"": ""http://rdf.rhea-db.org/11113 rh:products http://rdf.rhea-db.org/11112_R; http://rdf.rhea-db.org/11112_R rh:contains1 http://rdf.rhea-db.org/Participant_11112_compound_5459; rh:compound http://rdf.rhea-db.org/Compound_5459; rh:chebi""}, {""reference_id"": ""RHEA:23825"", ""source_assertion"": ""RHEA:23825 has CHEBI:58764 on its substrates side via its participant and compound objects."", ""source_locator"": ""http://rdf.rhea-db.org/23825 rh:substrates http://rdf.rhea-db.org/23824_L; http://rdf.rhea-db.org/23824_L rh:contains1 http://rdf.rhea-db.org/Participant_23824_compound_5459; rh:compound http://rdf.rhea-db.org/Compound_5459; rh:chebi""}, {""reference_id"": ""PMID:4928016"", ""source_assertion"": ""K-12 mutant extract complementation and intermediate accumulation resolve the EntC, EntB and EntA sequence from chorismate through isochorismate and dihydro-dihydroxybenzoate to DHB."", ""source_locator"": ""PMC248643 full PDF pp.54-55, Identification of enzyme deficiency; Tables 2 and 3""}]"	"[{""id"": ""MetaCyc:PWY-5901"", ""source_sha256"": ""2b978bba42064a27efcf351934b22c6c0fa9c335e1f24965cc70897daf22427c"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""MetaCyc PWY-5901: exact native definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5901""}, {""id"": ""PMID:4928016"", ""source_sha256"": ""297a466d033a1c5898897547cf390837d23aa3ff25b97cb32318b3c0bd8c7aae"", ""source_version"": ""1971; complete scanned primary PDF, independently extracted and rendered; retrieved 2026-10-11 UTC"", ""title"": ""Biosynthesis of the iron-transport compound enterochelin: mutants of Escherichia coli unable to synthesize 2,3-dihydroxybenzoate."", ""url"": ""https://europepmc.org/articles/PMC248643?pdf=render""}, {""id"": ""RHEA:11113"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 11113"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:23825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact subjects selected by evidence locators"", ""title"": ""Rhea directional reaction 23825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-001_6b6d72dd43d9	CHEBI:17272	pathwaymech:consumes	RHEA:20374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20374		"[{""reference_id"": ""RHEA:20374"", ""source_assertion"": ""RHEA:20374 assigns CHEBI:17272 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20374']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/20373_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_20373_compound_4801']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:20374"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 20374 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-002_3fffc844e7c3	CHEBI:30616	pathwaymech:consumes	RHEA:20374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20374		"[{""reference_id"": ""RHEA:20374"", ""source_assertion"": ""RHEA:20374 assigns CHEBI:30616 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20374']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/20373_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_20373_compound_6372']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:20374"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 20374 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-003_caf6788680dc	CHEBI:57287	pathwaymech:consumes	RHEA:20374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20374		"[{""reference_id"": ""RHEA:20374"", ""source_assertion"": ""RHEA:20374 assigns CHEBI:57287 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20374']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/20373_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_20373_compound_1264']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:20374"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 20374 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-004_2783b6af53cd	RHEA:20374	pathwaymech:produces	CHEBI:57392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20374		"[{""reference_id"": ""RHEA:20374"", ""source_assertion"": ""RHEA:20374 assigns CHEBI:57392 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20374']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/20373_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_20373_compound_3421']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:20374"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 20374 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-005_85079b0282b7	RHEA:20374	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20374		"[{""reference_id"": ""RHEA:20374"", ""source_assertion"": ""RHEA:20374 assigns CHEBI:456215 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20374']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/20373_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_20373_compound_2590']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:20374"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 20374 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-006_23fa1c492c8f	RHEA:20374	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20374		"[{""reference_id"": ""RHEA:20374"", ""source_assertion"": ""RHEA:20374 assigns CHEBI:33019 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20374']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/20373_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_20373_compound_2106']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:20374"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 20374 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-007_c5e01b976e2e	CHEBI:57392	pathwaymech:consumes	RHEA:57493	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57493		"[{""reference_id"": ""RHEA:57493"", ""source_assertion"": ""RHEA:57493 assigns CHEBI:57392 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/57493']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/57492_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_57492_compound_3421']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:57493"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 57493 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-008_c9d8c2c6a1ec	CHEBI:16452	pathwaymech:consumes	RHEA:57493	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57493		"[{""reference_id"": ""RHEA:57493"", ""source_assertion"": ""RHEA:57493 assigns CHEBI:16452 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/57493']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/57492_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_57492_compound_5219']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:57493"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 57493 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-009_dc4d9a16e972	CHEBI:15377	pathwaymech:consumes	RHEA:57493	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57493		"[{""reference_id"": ""RHEA:57493"", ""source_assertion"": ""RHEA:57493 assigns CHEBI:15377 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/57493']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/57492_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_57492_compound_1283']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:57493"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 57493 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-010_520d553aee36	RHEA:57493	pathwaymech:produces	CHEBI:15598	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57493	Stereounspecified source identity: this edge leaves methylcitrate absolute configuration unresolved and does not assert utilization or production of every stereoisomer.	"[{""reference_id"": ""RHEA:57493"", ""source_assertion"": ""RHEA:57493 assigns CHEBI:15598 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/57493']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/57492_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_57492_compound_14908']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:57493"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 57493 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-011_d559e38ac4ff	RHEA:57493	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57493		"[{""reference_id"": ""RHEA:57493"", ""source_assertion"": ""RHEA:57493 assigns CHEBI:57287 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/57493']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/57492_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_57492_compound_1264']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:57493"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 57493 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-012_6aff55f7e1bb	RHEA:57493	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57493		"[{""reference_id"": ""RHEA:57493"", ""source_assertion"": ""RHEA:57493 assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/57493']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/57492_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_57492_compound_3249']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:57493"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 57493 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-013_96192aeddbe5	CHEBI:15598	pathwaymech:consumes	RHEA:57497	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57497	Stereounspecified source identity: this edge leaves methylcitrate absolute configuration unresolved and does not assert utilization or production of every stereoisomer.	"[{""reference_id"": ""RHEA:57497"", ""source_assertion"": ""RHEA:57497 assigns CHEBI:15598 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/57497']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/57496_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_57496_compound_14908']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:57497"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 57497 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-014_78a154859698	RHEA:57497	pathwaymech:produces	CHEBI:57872	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57497		"[{""reference_id"": ""RHEA:57497"", ""source_assertion"": ""RHEA:57497 assigns CHEBI:57872 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/57497']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/57496_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_57496_compound_3416']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:57497"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 57497 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-015_0c4e8ffca5d7	RHEA:57497	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57497		"[{""reference_id"": ""RHEA:57497"", ""source_assertion"": ""RHEA:57497 assigns CHEBI:15377 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/57497']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/57496_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_57496_compound_1283']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:57497"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 57497 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-016_5495d175c0e2	CHEBI:57872	pathwaymech:consumes	RHEA:17943	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17943		"[{""reference_id"": ""RHEA:17943"", ""source_assertion"": ""RHEA:17943 assigns CHEBI:57872 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17943']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/17941_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_17941_compound_3416']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:17943"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 17943 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-017_fea96cb7c098	CHEBI:15377	pathwaymech:consumes	RHEA:17943	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17943		"[{""reference_id"": ""RHEA:17943"", ""source_assertion"": ""RHEA:17943 assigns CHEBI:15377 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17943']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/17941_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_17941_compound_1283']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:17943"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 17943 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-018_ea54c2161f90	RHEA:17943	pathwaymech:produces	CHEBI:57429	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17943		"[{""reference_id"": ""RHEA:17943"", ""source_assertion"": ""RHEA:17943 assigns CHEBI:57429 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17943']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/17941_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_17941_compound_1381']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:17943"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 17943 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-019_452ba70f7ddc	CHEBI:57429	pathwaymech:consumes	RHEA:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16810		"[{""reference_id"": ""RHEA:16810"", ""source_assertion"": ""RHEA:16810 assigns CHEBI:57429 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16810']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16809_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16809_compound_1381']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:16810"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 16810 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-020_5700fbcf6482	RHEA:16810	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16810		"[{""reference_id"": ""RHEA:16810"", ""source_assertion"": ""RHEA:16810 assigns CHEBI:15361 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16810']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16809_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16809_compound_3719']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:16810"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 16810 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-021_bf38a19d7921	RHEA:16810	pathwaymech:produces	CHEBI:30031	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16810		"[{""reference_id"": ""RHEA:16810"", ""source_assertion"": ""RHEA:16810 assigns CHEBI:30031 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16810']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16809_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16809_compound_2501']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:16810"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 16810 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-022_ad64b086580b	RHEA:20374	BFO:0000050	MetaCyc:PWY0-42	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PROPIONATE--COA-LIGASE-RXN|MetaCyc:PWY0-42|RHEA:20374		"[{""reference_id"": ""MetaCyc:PWY0-42"", ""source_assertion"": ""PWY0-42 includes PROPIONATE--COA-LIGASE-RXN in its five-member reaction-list."", ""source_locator"": ""Pathway[@frameid=\""PWY0-42\""]/reaction-list/Reaction[@frameid=\""PROPIONATE--COA-LIGASE-RXN\""]""}, {""reference_id"": ""MetaCyc:PROPIONATE--COA-LIGASE-RXN"", ""source_assertion"": ""PROPIONATE--COA-LIGASE-RXN has native Rhea cross-reference 20373."", ""source_locator"": ""Reaction[@frameid=\""PROPIONATE--COA-LIGASE-RXN\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:20374"", ""source_assertion"": ""Rhea master 20373 contains directed reaction 20374 and the native reaction cross-reference 20373 within its family."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/20373\""]/rh:directionalReaction,rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:PROPIONATE--COA-LIGASE-RXN"", ""source_sha256"": ""6ab112f8f76575a21e991fc4b4e4d86670d3187b7fe7bacd4947c8c50a1001f5"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc PROPIONATE--COA-LIGASE-RXN native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROPIONATE--COA-LIGASE-RXN""}, {""id"": ""MetaCyc:PWY0-42"", ""source_sha256"": ""94b1ed597329a37b310717ae629db366644e504111cefcbfbdb0116170d56d25"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc PWY0-42 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-42""}, {""id"": ""RHEA:20374"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 20374 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-023_93848f3e0294	RHEA:57493	BFO:0000050	MetaCyc:PWY0-42	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:2-METHYLCITRATE-SYNTHASE-RXN|MetaCyc:PWY0-42|RHEA:57493	The native reaction is stereospecific. This membership uses the separately issued generic parent reaction to represent the same supported pathway transformation while leaving the disputed methylcitrate configuration unspecified; no exactMatch is asserted.	"[{""reference_id"": ""MetaCyc:PWY0-42"", ""source_assertion"": ""PWY0-42 includes 2-METHYLCITRATE-SYNTHASE-RXN in its five-member reaction-list."", ""source_locator"": ""Pathway[@frameid=\""PWY0-42\""]/reaction-list/Reaction[@frameid=\""2-METHYLCITRATE-SYNTHASE-RXN\""]""}, {""reference_id"": ""MetaCyc:2-METHYLCITRATE-SYNTHASE-RXN"", ""source_assertion"": ""2-METHYLCITRATE-SYNTHASE-RXN has native Rhea cross-reference 23783."", ""source_locator"": ""Reaction[@frameid=\""2-METHYLCITRATE-SYNTHASE-RXN\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:57493"", ""source_assertion"": ""Rhea master 23780 is a subclass of approved generic master 57492; the latter cites PMID:28956599 and supplies directed reaction 57493."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/23780\""]/rdfs:subClassOf; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/57492\""]/rh:status,rh:citation,rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:2-METHYLCITRATE-SYNTHASE-RXN"", ""source_sha256"": ""8b3bc404235fd244afcbe24296ffa09e21a76f44852c7c62a6a47d238cba1c67"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc 2-METHYLCITRATE-SYNTHASE-RXN native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:2-METHYLCITRATE-SYNTHASE-RXN""}, {""id"": ""MetaCyc:PWY0-42"", ""source_sha256"": ""94b1ed597329a37b310717ae629db366644e504111cefcbfbdb0116170d56d25"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc PWY0-42 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-42""}, {""id"": ""RHEA:57493"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 57493 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-024_0ec49eb1c281	RHEA:57497	BFO:0000050	MetaCyc:PWY0-42	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:2-METHYLCITRATE-DEHYDRATASE-RXN|MetaCyc:PWY0-42|RHEA:57497	The native reaction is stereospecific. This membership uses the separately issued generic parent reaction to represent the same supported pathway transformation while leaving the disputed methylcitrate configuration unspecified; no exactMatch is asserted.	"[{""reference_id"": ""MetaCyc:PWY0-42"", ""source_assertion"": ""PWY0-42 includes 2-METHYLCITRATE-DEHYDRATASE-RXN in its five-member reaction-list."", ""source_locator"": ""Pathway[@frameid=\""PWY0-42\""]/reaction-list/Reaction[@frameid=\""2-METHYLCITRATE-DEHYDRATASE-RXN\""]""}, {""reference_id"": ""MetaCyc:2-METHYLCITRATE-DEHYDRATASE-RXN"", ""source_assertion"": ""2-METHYLCITRATE-DEHYDRATASE-RXN has native Rhea cross-reference 17728."", ""source_locator"": ""Reaction[@frameid=\""2-METHYLCITRATE-DEHYDRATASE-RXN\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:57497"", ""source_assertion"": ""Rhea master 17725 is a subclass of approved generic master 57496; the latter cites PMID:28956599 and supplies directed reaction 57497."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/17725\""]/rdfs:subClassOf; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/57496\""]/rh:status,rh:citation,rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:2-METHYLCITRATE-DEHYDRATASE-RXN"", ""source_sha256"": ""68fd51a3f1e4b54add580714fd1ff3634630db53f7312f72524b5ed0c16778a0"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc 2-METHYLCITRATE-DEHYDRATASE-RXN native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:2-METHYLCITRATE-DEHYDRATASE-RXN""}, {""id"": ""MetaCyc:PWY0-42"", ""source_sha256"": ""94b1ed597329a37b310717ae629db366644e504111cefcbfbdb0116170d56d25"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc PWY0-42 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-42""}, {""id"": ""RHEA:57497"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 57497 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-025_75b6230c03b0	RHEA:17943	BFO:0000050	MetaCyc:PWY0-42	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:4.2.1.99-RXN|MetaCyc:PWY0-42|RHEA:17943		"[{""reference_id"": ""MetaCyc:PWY0-42"", ""source_assertion"": ""PWY0-42 includes 4.2.1.99-RXN in its five-member reaction-list."", ""source_locator"": ""Pathway[@frameid=\""PWY0-42\""]/reaction-list/Reaction[@frameid=\""4.2.1.99-RXN\""]""}, {""reference_id"": ""MetaCyc:4.2.1.99-RXN"", ""source_assertion"": ""4.2.1.99-RXN has native Rhea cross-reference 17944."", ""source_locator"": ""Reaction[@frameid=\""4.2.1.99-RXN\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:17943"", ""source_assertion"": ""Rhea master 17941 contains directed reaction 17943 and the native reaction cross-reference 17944 within its family."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/17941\""]/rh:directionalReaction,rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:4.2.1.99-RXN"", ""source_sha256"": ""581159cc0ce8df05dbfb817a3998cd5102e13dd73bbc3cbdfed5c7630a0d72b7"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc 4.2.1.99-RXN native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:4.2.1.99-RXN""}, {""id"": ""MetaCyc:PWY0-42"", ""source_sha256"": ""94b1ed597329a37b310717ae629db366644e504111cefcbfbdb0116170d56d25"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc PWY0-42 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-42""}, {""id"": ""RHEA:17943"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 17943 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-026_4240fbc984f5	RHEA:16810	BFO:0000050	MetaCyc:PWY0-42	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:METHYLISOCITRATE-LYASE-RXN|MetaCyc:PWY0-42|RHEA:16810		"[{""reference_id"": ""MetaCyc:PWY0-42"", ""source_assertion"": ""PWY0-42 includes METHYLISOCITRATE-LYASE-RXN in its five-member reaction-list."", ""source_locator"": ""Pathway[@frameid=\""PWY0-42\""]/reaction-list/Reaction[@frameid=\""METHYLISOCITRATE-LYASE-RXN\""]""}, {""reference_id"": ""MetaCyc:METHYLISOCITRATE-LYASE-RXN"", ""source_assertion"": ""METHYLISOCITRATE-LYASE-RXN has native Rhea cross-reference 16812."", ""source_locator"": ""Reaction[@frameid=\""METHYLISOCITRATE-LYASE-RXN\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:16810"", ""source_assertion"": ""Rhea master 16809 contains directed reaction 16810 and the native reaction cross-reference 16812 within its family."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/16809\""]/rh:directionalReaction,rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:METHYLISOCITRATE-LYASE-RXN"", ""source_sha256"": ""5975d4eee852998fcc842990cb7dfdee56231f5ca3240c15b24cfdaaad9f0e39"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc METHYLISOCITRATE-LYASE-RXN native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:METHYLISOCITRATE-LYASE-RXN""}, {""id"": ""MetaCyc:PWY0-42"", ""source_sha256"": ""94b1ed597329a37b310717ae629db366644e504111cefcbfbdb0116170d56d25"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc PWY0-42 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-42""}, {""id"": ""RHEA:16810"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 16810 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-027_80c870fa4f78	RHEA:20374	RO:0002413	RHEA:57493	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-42|RHEA:20374|RHEA:57493	Material transfer through CHEBI:57392. Ordering is not a thermodynamic irreversibility claim.	"[{""reference_id"": ""MetaCyc:PWY0-42"", ""source_assertion"": ""The native ordering places PROPIONATE--COA-LIGASE-RXN immediately before 2-METHYLCITRATE-SYNTHASE-RXN."", ""source_locator"": ""Pathway[@frameid=\""PWY0-42\""]/reaction-ordering[Reaction/@frameid=\""2-METHYLCITRATE-SYNTHASE-RXN\""]/predecessor-reactions""}, {""reference_id"": ""RHEA:20374"", ""source_assertion"": ""RHEA:20374 assigns CHEBI:57392 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20374']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/20373_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_20373_compound_3421']; rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:57493"", ""source_assertion"": ""RHEA:57493 assigns CHEBI:57392 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/57493']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/57492_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_57492_compound_3421']; rh:compound/rh:chebi""}]"	"[{""id"": ""MetaCyc:PWY0-42"", ""source_sha256"": ""94b1ed597329a37b310717ae629db366644e504111cefcbfbdb0116170d56d25"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc PWY0-42 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-42""}, {""id"": ""RHEA:20374"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 20374 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:57493"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 57493 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-028_854929f3b1cd	RHEA:57493	RO:0002413	RHEA:57497	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-42|RHEA:57493|RHEA:57497	Material transfer through CHEBI:15598; the methylcitrate transfer retains an unspecified absolute configuration.	"[{""reference_id"": ""MetaCyc:PWY0-42"", ""source_assertion"": ""The native ordering places 2-METHYLCITRATE-SYNTHASE-RXN immediately before 2-METHYLCITRATE-DEHYDRATASE-RXN."", ""source_locator"": ""Pathway[@frameid=\""PWY0-42\""]/reaction-ordering[Reaction/@frameid=\""2-METHYLCITRATE-DEHYDRATASE-RXN\""]/predecessor-reactions""}, {""reference_id"": ""RHEA:57493"", ""source_assertion"": ""RHEA:57493 assigns CHEBI:15598 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/57493']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/57492_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_57492_compound_14908']; rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:57497"", ""source_assertion"": ""RHEA:57497 assigns CHEBI:15598 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/57497']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/57496_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_57496_compound_14908']; rh:compound/rh:chebi""}]"	"[{""id"": ""MetaCyc:PWY0-42"", ""source_sha256"": ""94b1ed597329a37b310717ae629db366644e504111cefcbfbdb0116170d56d25"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc PWY0-42 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-42""}, {""id"": ""RHEA:57493"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 57493 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:57497"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 57497 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-029_79c05cb0d040	RHEA:57497	RO:0002413	RHEA:17943	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-42|RHEA:17943|RHEA:57497	Material transfer through CHEBI:57872. Ordering is not a thermodynamic irreversibility claim.	"[{""reference_id"": ""MetaCyc:PWY0-42"", ""source_assertion"": ""The native ordering places 2-METHYLCITRATE-DEHYDRATASE-RXN immediately before 4.2.1.99-RXN."", ""source_locator"": ""Pathway[@frameid=\""PWY0-42\""]/reaction-ordering[Reaction/@frameid=\""4.2.1.99-RXN\""]/predecessor-reactions""}, {""reference_id"": ""RHEA:57497"", ""source_assertion"": ""RHEA:57497 assigns CHEBI:57872 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/57497']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/57496_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_57496_compound_3416']; rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:17943"", ""source_assertion"": ""RHEA:17943 assigns CHEBI:57872 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17943']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/17941_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_17941_compound_3416']; rh:compound/rh:chebi""}]"	"[{""id"": ""MetaCyc:PWY0-42"", ""source_sha256"": ""94b1ed597329a37b310717ae629db366644e504111cefcbfbdb0116170d56d25"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc PWY0-42 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-42""}, {""id"": ""RHEA:17943"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 17943 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:57497"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 57497 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-030_ab348cc86610	RHEA:17943	RO:0002413	RHEA:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-42|RHEA:16810|RHEA:17943	Material transfer through CHEBI:57429. Ordering is not a thermodynamic irreversibility claim.	"[{""reference_id"": ""MetaCyc:PWY0-42"", ""source_assertion"": ""The native ordering places 4.2.1.99-RXN immediately before METHYLISOCITRATE-LYASE-RXN."", ""source_locator"": ""Pathway[@frameid=\""PWY0-42\""]/reaction-ordering[Reaction/@frameid=\""METHYLISOCITRATE-LYASE-RXN\""]/predecessor-reactions""}, {""reference_id"": ""RHEA:17943"", ""source_assertion"": ""RHEA:17943 assigns CHEBI:57429 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17943']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/17941_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_17941_compound_1381']; rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:16810"", ""source_assertion"": ""RHEA:16810 assigns CHEBI:57429 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16810']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16809_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16809_compound_1381']; rh:compound/rh:chebi""}]"	"[{""id"": ""MetaCyc:PWY0-42"", ""source_sha256"": ""94b1ed597329a37b310717ae629db366644e504111cefcbfbdb0116170d56d25"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc PWY0-42 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-42""}, {""id"": ""RHEA:16810"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 16810 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:17943"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 17943 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-031_8a6d62be9ca2	UniProtKB:P31660	BFO:0000050	MetaCyc:CPLX0-251	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-251|MetaCyc:G6198-MONOMER|UniProtKB:P31660	Native assembly stoichiometry is 2 identical subunits; membership does not assert individual-subunit sufficiency.	"[{""reference_id"": ""MetaCyc:CPLX0-251"", ""source_assertion"": ""CPLX0-251 contains 2 copies of G6198-MONOMER."", ""source_locator"": ""Protein[@frameid=\""CPLX0-251\""]/component/Protein; component/coefficient""}, {""reference_id"": ""MetaCyc:G6198-MONOMER"", ""source_assertion"": ""G6198-MONOMER has UniProt cross-reference P31660."", ""source_locator"": ""Protein[@frameid=\""G6198-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}, {""reference_id"": ""UniProtKB:P31660"", ""source_assertion"": ""The reviewed SUBUNIT annotation states homodimer (ECO:0000269; PMID:9579066)."", ""source_locator"": ""$.comments[?(@.commentType==\""SUBUNIT\"")]""}]"	"[{""id"": ""MetaCyc:CPLX0-251"", ""source_sha256"": ""410171166cadd69e5e2e7946d46baa319279d781df9fcf138ecdca18526b4b79"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc CPLX0-251 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-251""}, {""id"": ""MetaCyc:G6198-MONOMER"", ""source_sha256"": ""2a1f194ecb547a8b1df0bbaf54e0950a0f1b5f54f5151ae08697f9351ee63022"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc G6198-MONOMER native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G6198-MONOMER""}, {""id"": ""UniProtKB:P31660"", ""source_sha256"": ""30f8f871558d241d0f0e7c00ac46242964b30bb7338656286e0804d46bc2282d"", ""source_version"": ""UniProt 2026_03; 02-September-2026; complete JSON body"", ""title"": ""2-methylcitrate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31660.json""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-032_134c7a2a8ea2	UniProtKB:P77541	BFO:0000050	MetaCyc:CPLX0-1021	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-1021|MetaCyc:G6196-MONOMER|UniProtKB:P77541	Native assembly stoichiometry is 4 identical subunits; membership does not assert individual-subunit sufficiency.	"[{""reference_id"": ""MetaCyc:CPLX0-1021"", ""source_assertion"": ""CPLX0-1021 contains 4 copies of G6196-MONOMER."", ""source_locator"": ""Protein[@frameid=\""CPLX0-1021\""]/component/Protein; component/coefficient""}, {""reference_id"": ""MetaCyc:G6196-MONOMER"", ""source_assertion"": ""G6196-MONOMER has UniProt cross-reference P77541."", ""source_locator"": ""Protein[@frameid=\""G6196-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}, {""reference_id"": ""UniProtKB:P77541"", ""source_assertion"": ""The reviewed SUBUNIT annotation states homotetramer, a dimer of dimers (ECO:0000269; PMID:12706720 and PMID:15723538; also HAMAP ECO:0000255)."", ""source_locator"": ""$.comments[?(@.commentType==\""SUBUNIT\"")]""}]"	"[{""id"": ""MetaCyc:CPLX0-1021"", ""source_sha256"": ""0058bd6365291fcd9fef871791e9e1eee9ebaac0e9ae449766a4db9daaa254d7"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc CPLX0-1021 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-1021""}, {""id"": ""MetaCyc:G6196-MONOMER"", ""source_sha256"": ""20a772c189010d30f41730bc00d5cbb5bda517a8f212520fa06006eea5f9ad10"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc G6196-MONOMER native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G6196-MONOMER""}, {""id"": ""UniProtKB:P77541"", ""source_sha256"": ""02fafccf438943d96480edd98500764903b34840a3c9eaae804460e3846bc729"", ""source_version"": ""UniProt 2026_03; 02-September-2026; complete JSON body"", ""title"": ""2-methylisocitrate lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77541.json""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-033_e8c6113febea	UniProtKB:P77495	pathwaymech:enables	RHEA:20374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:G6200-MONOMER|UniProtKB:P77495	Alternative annotated activation role. The E. coli reviewed FUNCTION is similarity-derived; the 2002 propionate-growth study favored Acs under its conditions. No essentiality or measured PrpE flux is asserted.	"[{""reference_id"": ""UniProtKB:P77495"", ""source_assertion"": ""FUNCTION assigns synthesis of propionyl-CoA from propionate and CoA by similarity (ECO:0000250); CATALYTIC ACTIVITY cross-references RHEA:20373."", ""source_locator"": ""$.comments[0:2]""}, {""reference_id"": ""MetaCyc:G6200-MONOMER"", ""source_assertion"": ""G6200-MONOMER maps to P77495 and catalyzes PROPIONATE--COA-LIGASE-RXN through ENZRXN0-7593."", ""source_locator"": ""Protein[@frameid=\""G6200-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]; catalyzes/Enzymatic-Reaction[@frameid=\""ENZRXN0-7593\""]/reaction""}]"	"[{""id"": ""MetaCyc:G6200-MONOMER"", ""source_sha256"": ""4a138bcdeb06df3b7ddd85c036023c66ebfd78ecbe1029eb34bfeaa7e64413e5"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc G6200-MONOMER native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G6200-MONOMER""}, {""id"": ""UniProtKB:P77495"", ""source_sha256"": ""710fb9c750a9db3d5ece89ca219716c4d7510738026e99d42fdee18f1e0da30c"", ""source_version"": ""UniProt 2026_03; 02-September-2026; complete JSON body"", ""title"": ""Propionate--CoA ligase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77495.json""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-034_2e1b0af5dcf2	UniProtKB:P27550	pathwaymech:enables	RHEA:20374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ACS-MONOMER|PMID:12473114	Native curated propionate activation role plus condition-specific primary physiological inference. Current UniProt CATALYTIC ACTIVITY describes acetate activation, not this propionate equation; it is not used as direct support for substrate promiscuity or exclusive Acs dependence.	"[{""reference_id"": ""MetaCyc:ACS-MONOMER"", ""source_assertion"": ""ACS-MONOMER maps to P27550 and catalyzes PROPIONATE--COA-LIGASE-RXN through ENZRXN0-1507."", ""source_locator"": ""Protein[@frameid=\""ACS-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]; catalyzes/Enzymatic-Reaction[@frameid=\""ENZRXN0-1507\""]/reaction""}, {""reference_id"": ""PMID:12473114"", ""source_assertion"": ""In propionate-grown E. coli, the abstract reports detection of prp-operon proteins except PrpE and proposes its replacement by acetyl-CoA synthetase."", ""source_locator"": ""$.resultList.result[0].abstractText; final two sentences""}]"	"[{""id"": ""MetaCyc:ACS-MONOMER"", ""source_sha256"": ""811414178fa3132d72c67bb8d455c7c7e6b771d8123e9da1816bc6a9a440ad2f"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc ACS-MONOMER native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ACS-MONOMER""}, {""id"": ""PMID:12473114"", ""source_sha256"": ""ba9ba61fa3b462cff84618dc187e5bd1db3add52644819e5006155c85f440839"", ""source_version"": ""2002 primary abstract via Europe PMC exact-PMID JSON; digest covers full API response"", ""title"": ""Oxidation of propionate to pyruvate in Escherichia coli. Involvement of methylcitrate dehydratase and aconitase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12473114/""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-035_e7f73edde8eb	MetaCyc:CPLX0-251	pathwaymech:catalyzes	RHEA:57493	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-251|PMID:28956599|RHEA:57493|UniProtKB:P31660	The catalytic transformation is established; its exact methylcitrate stereochemical product is not selected. The source-issued generic reaction is used, not a modified RHEA:23781 equation.	"[{""reference_id"": ""MetaCyc:CPLX0-251"", ""source_assertion"": ""The PrpC complex catalyzes 2-METHYLCITRATE-SYNTHASE-RXN through ENZRXN0-245."", ""source_locator"": ""Protein[@frameid=\""CPLX0-251\""]/catalyzes/Enzymatic-Reaction[@frameid=\""ENZRXN0-245\""]/reaction""}, {""reference_id"": ""UniProtKB:P31660"", ""source_assertion"": ""FUNCTION assigns condensation of propionyl-CoA and oxaloacetate to methylcitrate and CoA (ECO:0000269). CAUTION preserves conflicting absolute stereochemistry assignments from PMID:12473114 and PMID:28956599."", ""source_locator"": ""$.comments[0]; $.comments[9]""}, {""reference_id"": ""PMID:28956599"", ""source_assertion"": ""The abstract reports that E. coli PrpC and B. subtilis MmgD generate the same methylcitrate stereoisomer, assigned alternatively as (2S,3R) or (2R,3S)."", ""source_locator"": ""$.resultList.result[0].abstractText""}, {""reference_id"": ""RHEA:57493"", ""source_assertion"": ""Approved generic synthesis reaction 57493 belongs to master 57492, which cites PMID:28956599 and is the parent of specific master 23780."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/57493\""]; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/23780\""]/rdfs:subClassOf""}]"	"[{""id"": ""MetaCyc:CPLX0-251"", ""source_sha256"": ""410171166cadd69e5e2e7946d46baa319279d781df9fcf138ecdca18526b4b79"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc CPLX0-251 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-251""}, {""id"": ""PMID:28956599"", ""source_sha256"": ""b75114ee34ed06a995e24ec060684b10ffb214111dc613e085d0c0b3f1446cfe"", ""source_version"": ""2017 primary abstract via Europe PMC exact-PMID JSON; digest covers full API response"", ""title"": ""First Biochemical Characterization of a Methylcitric Acid Cycle from Bacillus subtilis Strain 168."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/28956599/""}, {""id"": ""RHEA:57493"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 57493 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P31660"", ""source_sha256"": ""30f8f871558d241d0f0e7c00ac46242964b30bb7338656286e0804d46bc2282d"", ""source_version"": ""UniProt 2026_03; 02-September-2026; complete JSON body"", ""title"": ""2-methylcitrate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31660.json""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-036_5be662d2f2ec	UniProtKB:P77243	pathwaymech:catalyzes	RHEA:57497	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:G6199-MONOMER|PMID:11782506|PMID:28956599|RHEA:57497|UniProtKB:P77243	This records the physiological cis-product branch, not universal stereoisomer acceptance. Native curation preserves disagreement over whether PrpD contains an iron-sulfur cluster; one primary study reports an unstable [2Fe-2S] cluster in its preparation. No obligatory cofactor or cofactor-independence edge is asserted.	"[{""reference_id"": ""UniProtKB:P77243"", ""source_assertion"": ""FUNCTION assigns dehydration of methylcitrate to cis-methylaconitate (ECO:0000269; PMID:11782506 and PMID:12473114); SUBUNIT states monomer. CAUTION retains the substrate stereochemistry conflict."", ""source_locator"": ""$.comments[0]; $.comments[6]; $.comments[11]""}, {""reference_id"": ""PMID:28956599"", ""source_assertion"": ""The abstract reports that E. coli PrpD can dehydrate at least two methylcitrate stereoisomers; the physiological pathways proceed through (Z)-2-methylaconitate."", ""source_locator"": ""$.resultList.result[0].abstractText""}, {""reference_id"": ""RHEA:57497"", ""source_assertion"": ""Approved generic dehydration 57497 belongs to master 57496, which cites PMID:28956599 and is the parent of specific master 17725."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/57497\""]; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/17725\""]/rdfs:subClassOf""}, {""reference_id"": ""MetaCyc:G6199-MONOMER"", ""source_assertion"": ""The native comment preserves disagreement between PMID:11782506 and PMID:12473114 over whether PrpD contains an iron-sulfur cluster. This is a curated conflict statement, not a resolution of the metal requirement."", ""source_locator"": ""Protein[@frameid=\""G6199-MONOMER\""]/comment""}, {""reference_id"": ""PMID:11782506"", ""source_assertion"": ""The primary abstract reports one unstable [2Fe-2S] cluster per purified PrpD monomer, needed for maximum catalytic activity in that preparation and reconstitutable with Fe(2+) under reducing conditions."", ""source_locator"": ""$.resultList.result[0].abstractText""}]"	"[{""id"": ""MetaCyc:G6199-MONOMER"", ""source_sha256"": ""dc8914e4d6d9b139343f77ccbe245d24a059d0cd917bf85597c72581ee8392e8"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc G6199-MONOMER native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G6199-MONOMER""}, {""id"": ""PMID:11782506"", ""source_sha256"": ""fa0a35710b54150751f47cd7e50fb89dd5f156cee3b4633f15a6170adbbc9025"", ""source_version"": ""2002 primary abstract via Europe PMC exact-PMID JSON; digest covers full API response"", ""title"": ""AcnC of Escherichia coli is a 2-methylcitrate dehydratase (PrpD) that can use citrate and isocitrate as substrates."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/11782506/""}, {""id"": ""PMID:28956599"", ""source_sha256"": ""b75114ee34ed06a995e24ec060684b10ffb214111dc613e085d0c0b3f1446cfe"", ""source_version"": ""2017 primary abstract via Europe PMC exact-PMID JSON; digest covers full API response"", ""title"": ""First Biochemical Characterization of a Methylcitric Acid Cycle from Bacillus subtilis Strain 168."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/28956599/""}, {""id"": ""RHEA:57497"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 is the full compressed official RDF gzip"", ""title"": ""Rhea 142 directed reaction 57497 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P77243"", ""source_sha256"": ""1f21774aa4d8887c3cfde27bc5e328f83aa3d899ee183251747cf7fa946a9922"", ""source_version"": ""UniProt 2026_03; 02-September-2026; complete JSON body"", ""title"": ""2-methylcitrate dehydratase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77243.json""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-037_aa958818a082	UniProtKB:P36683	pathwaymech:enables	RHEA:17943	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12473114|UniProtKB:P36683	Functional gene-product role, without fixing a condition-independent oligomeric state. Native CPLX0-7761 has one component without a coefficient; current evidence supports conditional monomer/dimer behavior. The catabolic hydration is Rhea right-to-left relative to the master equation.	"[{""reference_id"": ""UniProtKB:P36683"", ""source_assertion"": ""FUNCTION assigns hydration of cis-2-methylaconitate to (2R,3S)-2-methylisocitrate; CATALYTIC ACTIVITY cites RHEA:17941 with ECO:0000269, PMID:12473114."", ""source_locator"": ""$.comments[0]; $.comments[2]""}, {""reference_id"": ""PMID:12473114"", ""source_assertion"": ""AcnB was purified from propionate-grown E. coli, identified by its N-terminus, and required with PrpD for conversion of methylcitrate to methylisocitrate."", ""source_locator"": ""$.resultList.result[0].abstractText""}, {""reference_id"": ""UniProtKB:P36683"", ""source_assertion"": ""SUBUNIT describes monomer and possible homodimer with iron-dependent interconversion (ECO:0000269)."", ""source_locator"": ""$.comments[7]""}]"	"[{""id"": ""PMID:12473114"", ""source_sha256"": ""ba9ba61fa3b462cff84618dc187e5bd1db3add52644819e5006155c85f440839"", ""source_version"": ""2002 primary abstract via Europe PMC exact-PMID JSON; digest covers full API response"", ""title"": ""Oxidation of propionate to pyruvate in Escherichia coli. Involvement of methylcitrate dehydratase and aconitase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12473114/""}, {""id"": ""UniProtKB:P36683"", ""source_sha256"": ""6b47f414de4336cbd14a07e459d1bc8c1a540dad0d4c1d10e899c79d2d212f45"", ""source_version"": ""UniProt 2026_03; 02-September-2026; complete JSON body"", ""title"": ""Aconitate hydratase B"", ""url"": ""https://rest.uniprot.org/uniprotkb/P36683.json""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-038_5e06e7bc8686	MetaCyc:CPLX0-1021	pathwaymech:catalyzes	RHEA:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-1021|PMID:11422389|UniProtKB:P77541		"[{""reference_id"": ""MetaCyc:CPLX0-1021"", ""source_assertion"": ""The PrpB complex catalyzes METHYLISOCITRATE-LYASE-RXN through ENZRXN0-1521."", ""source_locator"": ""Protein[@frameid=\""CPLX0-1021\""]/catalyzes/Enzymatic-Reaction[@frameid=\""ENZRXN0-1521\""]/reaction""}, {""reference_id"": ""UniProtKB:P77541"", ""source_assertion"": ""CATALYTIC ACTIVITY assigns methylisocitrate cleavage to pyruvate and succinate, RHEA:16809 (ECO:0000269; PMID:11422389 and PMID:15723538; also HAMAP ECO:0000255)."", ""source_locator"": ""$.comments[1]""}, {""reference_id"": ""PMID:11422389"", ""source_assertion"": ""The purified E. coli PrpB is homotetrameric by size-exclusion chromatography and cleaves threo-methylisocitrate; the erythro diastereomer was inactive."", ""source_locator"": ""$.resultList.result[0].abstractText""}]"	"[{""id"": ""MetaCyc:CPLX0-1021"", ""source_sha256"": ""0058bd6365291fcd9fef871791e9e1eee9ebaac0e9ae449766a4db9daaa254d7"", ""source_version"": ""MetaCyc public native XML; mirror 22.5; complete response body"", ""title"": ""MetaCyc CPLX0-1021 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-1021""}, {""id"": ""PMID:11422389"", ""source_sha256"": ""54bf36b279e36f612d381adddd18e72f09db8d2572a8e6d53a4746807d8e4335"", ""source_version"": ""2001 primary abstract via Europe PMC exact-PMID JSON; digest covers full API response"", ""title"": ""2-Methylisocitrate lyases from the bacterium Escherichia coli and the filamentous fungus Aspergillus nidulans: characterization and comparison of both enzymes."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/11422389/""}, {""id"": ""UniProtKB:P77541"", ""source_sha256"": ""02fafccf438943d96480edd98500764903b34840a3c9eaae804460e3846bc729"", ""source_version"": ""UniProt 2026_03; 02-September-2026; complete JSON body"", ""title"": ""2-methylisocitrate lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77541.json""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-039_5cc33ba9c17b	UniProtKB:P27550	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P27550	Protein-level curated cofactor annotation; alternative-metal ranking is source-specific, not a newly measured propionate-specific metal series.	"[{""reference_id"": ""UniProtKB:P27550"", ""source_assertion"": ""COFACTOR assigns Mg2+ with ECO:0000269 (PMID:15327942 and PMID:21941) and HAMAP ECO:0000255; other divalent metals support decreasing activity in the order Mg, Mn, Ca, Ni."", ""source_locator"": ""$.comments[3]""}]"	"[{""id"": ""UniProtKB:P27550"", ""source_sha256"": ""3c4d153c7c2a2a8b4999ee7ea81e19fddb62fd728055950b16ae095c3febfeb6"", ""source_version"": ""UniProt 2026_03; 02-September-2026; complete JSON body"", ""title"": ""Acetyl-coenzyme A synthetase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P27550.json""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-040_d82184cd4d76	UniProtKB:P36683	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36683	Catalytically active aconitase context; apo-AcnB RNA regulation and oxidative-stress effects are outside the chemical route.	"[{""reference_id"": ""UniProtKB:P36683"", ""source_assertion"": ""COFACTOR assigns one [4Fe-4S] cluster per subunit, CHEBI:49883 (ECO:0000269; PMID:11992126)."", ""source_locator"": ""$.comments[3]""}]"	"[{""id"": ""UniProtKB:P36683"", ""source_sha256"": ""6b47f414de4336cbd14a07e459d1bc8c1a540dad0d4c1d10e899c79d2d212f45"", ""source_version"": ""UniProt 2026_03; 02-September-2026; complete JSON body"", ""title"": ""Aconitate hydratase B"", ""url"": ""https://rest.uniprot.org/uniprotkb/P36683.json""}]"	""
pathwaymech:MetaCyc_PWY0-42_methylcitrate-edge-041_e7f9d4f129aa	MetaCyc:CPLX0-1021	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12706720|UniProtKB:P77541		"[{""reference_id"": ""UniProtKB:P77541"", ""source_assertion"": ""COFACTOR assigns Mg2+, CHEBI:18420, with experimental ECO:0000269 references PMID:11422389, PMID:12706720 and PMID:15723538, plus HAMAP ECO:0000255."", ""source_locator"": ""$.comments[2]""}, {""reference_id"": ""PMID:12706720"", ""source_assertion"": ""The primary abstract states that E. coli PrpB strictly depends on Mg2+ for catalysis."", ""source_locator"": ""$.resultList.result[0].abstractText""}]"	"[{""id"": ""PMID:12706720"", ""source_sha256"": ""0d6a704e59a921b15ad8237a1024cb3d57877ac2ddaff1d20ce6efb08336c7b8"", ""source_version"": ""2003 primary abstract via Europe PMC exact-PMID JSON; digest covers full API response"", ""title"": ""Crystal structure of 2-methylisocitrate lyase (PrpB) from Escherichia coli and modelling of its ligand bound active centre."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12706720/""}, {""id"": ""UniProtKB:P77541"", ""source_sha256"": ""02fafccf438943d96480edd98500764903b34840a3c9eaae804460e3846bc729"", ""source_version"": ""UniProt 2026_03; 02-September-2026; complete JSON body"", ""title"": ""2-methylisocitrate lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77541.json""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-1_221c1b27a4a0	CHEBI:18150	pathwaymech:consumes	WikiPathways:WP5587/id32159333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML id32159333 connects normalized CHEBI:18150 as an input of interaction id32159333."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id32159333']/Graphics; /Pathway/DataNode[@GraphId='e43bf']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-2_35180e651384	WikiPathways:WP5587/id32159333	pathwaymech:produces	CHEBI:16119	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML id32159333 connects normalized CHEBI:16119 as an output of interaction id32159333."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id32159333']/Graphics; /Pathway/DataNode[@GraphId='ad2cf']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-3_3a2947a98130	CHEBI:16666	pathwaymech:consumes	WikiPathways:WP5587/id42570815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML id42570815 connects normalized CHEBI:16666 as an input of interaction id42570815."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id42570815']/Graphics; /Pathway/DataNode[@GraphId='bca0f']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-4_a9f85a71081f	WikiPathways:WP5587/id42570815	pathwaymech:produces	CHEBI:18005	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML id42570815 connects normalized CHEBI:18005 as an output of interaction id42570815."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id42570815']/Graphics; /Pathway/DataNode[@GraphId='c3273']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-5_5d70ff9eff86	CHEBI:4167	pathwaymech:consumes	WikiPathways:WP5587/id5c945cbf	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML id5c945cbf connects normalized CHEBI:4167 as an input of interaction id5c945cbf."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5c945cbf']/Graphics; /Pathway/DataNode[@GraphId='cac7e']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-6_346917aa674e	WikiPathways:WP5587/id5c945cbf	pathwaymech:produces	CHEBI:4170	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML id5c945cbf connects normalized CHEBI:4170 as an output of interaction id5c945cbf."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5c945cbf']/Graphics; /Pathway/DataNode[@GraphId='f3b4d']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-7_6dad90eef3a4	CHEBI:16424	pathwaymech:consumes	WikiPathways:WP5587/id7ed21248	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML id7ed21248 connects normalized CHEBI:16424 as an input of interaction id7ed21248."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id7ed21248']/Graphics; /Pathway/DataNode[@GraphId='c6b39']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-8_d6e00a029804	WikiPathways:WP5587/id7ed21248	pathwaymech:produces	CHEBI:49000	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML id7ed21248 connects normalized CHEBI:49000 as an output of interaction id7ed21248."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id7ed21248']/Graphics; /Pathway/DataNode[@GraphId='e6b13']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-9_a896888a3a59	WikiPathways:WP5587/id864096aa	pathwaymech:produces	CHEBI:18005	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587	The source has arrowheads on both endpoints; the displayed orientation is one direction of a reversible conversion.	"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML id864096aa connects normalized CHEBI:18005 as an output of interaction id864096aa."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id864096aa']/Graphics; /Pathway/DataNode[@GraphId='c3273']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-10_832b21837984	CHEBI:58095	pathwaymech:consumes	WikiPathways:WP5587/id864096aa	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587	The source has arrowheads on both endpoints; the displayed orientation is one direction of a reversible conversion.	"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML id864096aa connects normalized CHEBI:58095 as an input of interaction id864096aa."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id864096aa']/Graphics; /Pathway/DataNode[@GraphId='a9433']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-11_5492b4c0edc4	CHEBI:18005	pathwaymech:consumes	WikiPathways:WP5587/id9510c196	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML id9510c196 connects normalized CHEBI:18005 as an input of interaction id9510c196."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id9510c196']/Graphics; /Pathway/DataNode[@GraphId='c3273']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-12_19af6dab6b62	WikiPathways:WP5587/id9510c196	pathwaymech:produces	CHEBI:16424	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML id9510c196 connects normalized CHEBI:16424 as an output of interaction id9510c196."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id9510c196']/Graphics; /Pathway/DataNode[@GraphId='c6b39']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-13_4865076150fa	CHEBI:16119	pathwaymech:consumes	WikiPathways:WP5587/idbd32b592	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML idbd32b592 connects normalized CHEBI:16119 as an input of interaction idbd32b592."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idbd32b592']/Graphics; /Pathway/DataNode[@GraphId='ad2cf']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-14_be3dd4d3f280	WikiPathways:WP5587/idbd32b592	pathwaymech:produces	CHEBI:29748	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML idbd32b592 connects normalized CHEBI:29748 as an output of interaction idbd32b592."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idbd32b592']/Graphics; /Pathway/DataNode[@GraphId='b4aee']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-15_105cb9fe8fa6	CHEBI:58702	pathwaymech:consumes	WikiPathways:WP5587/idc5e5e165	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML idc5e5e165 connects normalized CHEBI:58702 as an input of interaction idc5e5e165."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idc5e5e165']/Graphics; /Pathway/DataNode[@GraphId='bd7fc']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-16_b3b01abdd2f0	WikiPathways:WP5587/idc5e5e165	pathwaymech:produces	CHEBI:18150	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML idc5e5e165 connects normalized CHEBI:18150 as an output of interaction idc5e5e165."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idc5e5e165']/Graphics; /Pathway/DataNode[@GraphId='e43bf']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-17_12c2f040562f	CHEBI:29748	pathwaymech:consumes	WikiPathways:WP5587/idda151004	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML idda151004 connects normalized CHEBI:29748 as an input of interaction idda151004."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idda151004']/Graphics; /Pathway/DataNode[@GraphId='b4aee']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-18_3d965ebb67e2	WikiPathways:WP5587/idda151004	pathwaymech:produces	CHEBI:16666	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML idda151004 connects normalized CHEBI:16666 as an output of interaction idda151004."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idda151004']/Graphics; /Pathway/DataNode[@GraphId='bca0f']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-19_cc13fa1743fc	CHEBI:4170	pathwaymech:consumes	WikiPathways:WP5587/idf0d0e924	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML idf0d0e924 connects normalized CHEBI:4170 as an input of interaction idf0d0e924."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idf0d0e924']/Graphics; /Pathway/DataNode[@GraphId='f3b4d']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-20_2f9409ef6b33	WikiPathways:WP5587/idf0d0e924	pathwaymech:produces	CHEBI:58702	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML idf0d0e924 connects normalized CHEBI:58702 as an output of interaction idf0d0e924."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idf0d0e924']/Graphics; /Pathway/DataNode[@GraphId='bd7fc']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-21_a7db2fb4525e	CHEBI:4170	pathwaymech:consumes	WikiPathways:WP5587/idf107e51d	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML idf107e51d connects normalized CHEBI:4170 as an input of interaction idf107e51d."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idf107e51d']/Graphics; /Pathway/DataNode[@GraphId='f3b4d']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-22_0a250008af12	WikiPathways:WP5587/idf107e51d	pathwaymech:produces	CHEBI:48153	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML idf107e51d connects normalized CHEBI:48153 as an output of interaction idf107e51d."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idf107e51d']/Graphics; /Pathway/DataNode[@GraphId='d8ea8']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-23_0916f70c3117	SGD:S000004918	pathwaymech:catalyzes	WikiPathways:WP5587/id7ed21248	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML id1c0fc9d0 connects normalized SGD:S000004918 as a catalyst of interaction id7ed21248."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id1c0fc9d0']/Graphics; /Pathway/DataNode[@GraphId='f7cdd']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-24_8cd5f40b4f1f	SGD:S000005185	pathwaymech:enables	WikiPathways:WP5587/idf107e51d	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML id20ec62a connects normalized SGD:S000005185 as an enabling enzyme component of interaction idf107e51d."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id20ec62a']/Graphics; /Pathway/DataNode[@GraphId='e2d53']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-25_2ea69daa8f03	SGD:S000002534	pathwaymech:enables	WikiPathways:WP5587/id32159333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML id38a08c22 connects normalized SGD:S000002534 as an enabling enzyme component of interaction id32159333."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id38a08c22']/Graphics; /Pathway/DataNode[@GraphId='ebf5e']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-26_cb3817c36fad	SGD:S000003424	pathwaymech:enables	WikiPathways:WP5587/idf0d0e924	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML id59c08d8c connects normalized SGD:S000003424 as an enabling enzyme component of interaction idf0d0e924."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id59c08d8c']/Graphics; /Pathway/DataNode[@GraphId='b7ee6']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-27_14e52e1a10ac	SGD:S000006264	pathwaymech:catalyzes	WikiPathways:WP5587/idda151004	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML id80e48618 connects normalized SGD:S000006264 as a catalyst of interaction idda151004."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id80e48618']/Graphics; /Pathway/DataNode[@GraphId='e7b42']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-28_02fb92cd896b	SGD:S000000453	pathwaymech:catalyzes	WikiPathways:WP5587/idc5e5e165	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML ida5d852b5 connects normalized SGD:S000000453 as a catalyst of interaction idc5e5e165."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ida5d852b5']/Graphics; /Pathway/DataNode[@GraphId='b38f0']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-29_10294171de0e	SGD:S000002788	pathwaymech:catalyzes	WikiPathways:WP5587/id9510c196	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML iddc9137a7 connects normalized SGD:S000002788 as a catalyst of interaction id9510c196."", ""source_locator"": ""/Pathway/Interaction[@GraphId='iddc9137a7']/Graphics; /Pathway/DataNode[@GraphId='d76fd']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-30_b01a734d1332	SGD:S000005260	pathwaymech:catalyzes	WikiPathways:WP5587/id42570815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML ide507376c connects normalized SGD:S000005260 as a catalyst of interaction id42570815."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ide507376c']/Graphics; /Pathway/DataNode[@GraphId='eccf3']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-31_8b0195551937	SGD:S000003170	pathwaymech:catalyzes	WikiPathways:WP5587/id864096aa	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML ide836cb7e connects normalized SGD:S000003170 as a catalyst of interaction id864096aa."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ide836cb7e']/Graphics; /Pathway/DataNode[@GraphId='fa3b6']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-32_52f2f11a7990	SGD:S000002442	pathwaymech:catalyzes	WikiPathways:WP5587/idc5e5e165	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587		"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML idebc2a294 connects normalized SGD:S000002442 as a catalyst of interaction idc5e5e165."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idebc2a294']/Graphics; /Pathway/DataNode[@GraphId='bb8b7']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_causal-review-33_009bb61c38c1	CHEBI:48153	pathwaymech:consumes	WikiPathways:WP5587/idc5e5e165	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5587	The two native DAHP input lines represent one condensation reaction.	"[{""reference_id"": ""WikiPathways:WP5587"", ""source_assertion"": ""GPML id88645eca connects normalized CHEBI:48153 as an input of interaction idc5e5e165."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id88645eca']/Graphics; /Pathway/DataNode[@GraphId='d8ea8']""}]"	"[{""id"": ""WikiPathways:WP5587"", ""source_sha256"": ""6b3564b0720473131a8fcc8e9dee27c697bdfae1b4fa80139b0329735776f608"", ""source_version"": ""WP5587_r142132"", ""title"": ""WP5587 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5587/WP5587.gpml""}]"	""
pathwaymech:WikiPathways_WP5587_cofactor-94921f5c2d4f_202617151bbe	SGD:S000002788	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06408	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/comments/0/cofactors/0; /results/2752/comments/0/note""}, {""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 has the exact SGD cross-reference SGD:S000002788."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q06408"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB Q06408 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5587_cofactor-2aff8723af5a_b08da833c27d	SGD:S000002788	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06408	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/comments/1/cofactors/0; /results/2752/comments/1/note""}, {""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 has the exact SGD cross-reference SGD:S000002788."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q06408"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB Q06408 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5587_cofactor-cd9d39e02356_c4a3bc4847e7	SGD:S000002534	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08566	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03143) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000255 (HAMAP-Rule:MF_03143)	"[{""reference_id"": ""UniProtKB:P08566"", ""source_assertion"": ""UniProtKB:P08566 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/213/comments/0/cofactors/0; /results/213/comments/0/note""}, {""reference_id"": ""UniProtKB:P08566"", ""source_assertion"": ""UniProtKB:P08566 has the exact SGD cross-reference SGD:S000002534."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/213/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P08566"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P08566 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5587_cofactor-ea44646ed080_d485988ec40c	SGD:S000004918	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00331	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	"[{""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/comments/0/cofactors/0; /results/23/comments/0/note""}, {""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00331"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P00331 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5587_cofactor-46a0dec0bfb8_908f47d47867	SGD:S000003170	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53090	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:23893908)	"[{""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 has the exact SGD cross-reference SGD:S000003170."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53090"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P53090 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:MetaCyc_PWY-6543_edge-001_3036b9186a47	CHEBI:29748	pathwaymech:consumes	RHEA:11673	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11673		"[{""reference_id"": ""RHEA:11673"", ""source_assertion"": ""Rhea lists CHEBI:29748 on the substrates side of RHEA:11673 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11673']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11673"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right aminodeoxychorismate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/11673""}]"	""
pathwaymech:MetaCyc_PWY-6543_edge-002_912a6bf984f1	CHEBI:58359	pathwaymech:consumes	RHEA:11673	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11673		"[{""reference_id"": ""RHEA:11673"", ""source_assertion"": ""Rhea lists CHEBI:58359 on the substrates side of RHEA:11673 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11673']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11673"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right aminodeoxychorismate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/11673""}]"	""
pathwaymech:MetaCyc_PWY-6543_edge-003_c9326c752345	RHEA:11673	pathwaymech:produces	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11673		"[{""reference_id"": ""RHEA:11673"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the products side of RHEA:11673 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11673']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11673"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right aminodeoxychorismate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/11673""}]"	""
pathwaymech:MetaCyc_PWY-6543_edge-004_131634806767	RHEA:11673	pathwaymech:produces	CHEBI:58406	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11673		"[{""reference_id"": ""RHEA:11673"", ""source_assertion"": ""Rhea lists CHEBI:58406 on the products side of RHEA:11673 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11673']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11673"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right aminodeoxychorismate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/11673""}]"	""
pathwaymech:MetaCyc_PWY-6543_edge-005_6919e3938354	CHEBI:58406	pathwaymech:consumes	RHEA:16202	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16202		"[{""reference_id"": ""RHEA:16202"", ""source_assertion"": ""Rhea lists CHEBI:58406 on the substrates side of RHEA:16202 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16202']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16202"", ""source_version"": ""139"", ""title"": ""Rhea 4-amino-4-deoxychorismate-to-4-aminobenzoate lyase direction"", ""url"": ""https://www.rhea-db.org/rhea/16202""}]"	""
pathwaymech:MetaCyc_PWY-6543_edge-006_fadb903e99f2	RHEA:16202	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16202		"[{""reference_id"": ""RHEA:16202"", ""source_assertion"": ""Rhea lists CHEBI:15361 on the products side of RHEA:16202 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16202']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16202"", ""source_version"": ""139"", ""title"": ""Rhea 4-amino-4-deoxychorismate-to-4-aminobenzoate lyase direction"", ""url"": ""https://www.rhea-db.org/rhea/16202""}]"	""
pathwaymech:MetaCyc_PWY-6543_edge-007_e723f547ac0b	RHEA:16202	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16202		"[{""reference_id"": ""RHEA:16202"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:16202 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16202']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16202"", ""source_version"": ""139"", ""title"": ""Rhea 4-amino-4-deoxychorismate-to-4-aminobenzoate lyase direction"", ""url"": ""https://www.rhea-db.org/rhea/16202""}]"	""
pathwaymech:MetaCyc_PWY-6543_edge-008_ce3a0cf9a3ec	RHEA:16202	pathwaymech:produces	CHEBI:17836	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16202		"[{""reference_id"": ""RHEA:16202"", ""source_assertion"": ""Rhea lists CHEBI:17836 on the products side of RHEA:16202 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16202']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16202"", ""source_version"": ""139"", ""title"": ""Rhea 4-amino-4-deoxychorismate-to-4-aminobenzoate lyase direction"", ""url"": ""https://www.rhea-db.org/rhea/16202""}]"	""
pathwaymech:MetaCyc_PWY-6543_edge-009_0c1ba1ae04a4	EC:2.6.1.85	pathwaymech:catalyzes	RHEA:11673	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:1644759|RHEA:11672		"[{""reference_id"": ""RHEA:11672"", ""source_assertion"": ""Rhea associates EC:2.6.1.85 with the reaction family containing RHEA:11673."", ""source_locator"": ""rh:ec""}, {""quote"": ""Aminodeoxychorismate synthase components I and II, encoded by pabB and pabA, respectively, convert chorismate and glutamine to 4-amino-4-deoxychorismate (ADC) and glutamate, respectively."", ""reference_id"": ""PMID:1644759"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Green et al., Journal of Bacteriology, 1992"", ""id"": ""PMID:1644759"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/1644759/""}, {""id"": ""RHEA:11672"", ""source_version"": ""139"", ""title"": ""Rhea aminodeoxychorismate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/11672""}]"	""
pathwaymech:MetaCyc_PWY-6543_edge-010_95f95365e901	EC:4.1.3.38	pathwaymech:catalyzes	RHEA:16202	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:2251281|RHEA:16201		"[{""reference_id"": ""RHEA:16201"", ""source_assertion"": ""Rhea associates EC:4.1.3.38 with the reaction family containing RHEA:16202."", ""source_locator"": ""rh:ec""}, {""quote"": ""Enzyme X shows no activity on chorismate but quantitatively converts the preformed aminodeoxychorismate into p-aminobenzoate and pyruvate, acting thereby as an aminodeoxychorismate lyase."", ""reference_id"": ""PMID:2251281"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Green and Nichols, Proceedings of the National Academy of Sciences, 1990"", ""id"": ""PMID:2251281"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/2251281/""}, {""id"": ""RHEA:16201"", ""source_version"": ""139"", ""title"": ""Rhea aminodeoxychorismate lyase reaction"", ""url"": ""https://www.rhea-db.org/rhea/16201""}]"	""
pathwaymech:MetaCyc_PWY-6543_edge-011_d5a8563d17f1	RHEA:11673	pathwaymech:precedes	RHEA:16202	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6543		"[{""reference_id"": ""MetaCyc:PWY-6543"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:11673 before RHEA:16202 in this pathway. Shared intermediate: CHEBI:58406."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-6543"", ""source_sha256"": ""d687b1b0a70b6e7e09f6af14d499dca6dc7e68272fe3f081f4a2520129a87355"", ""source_version"": ""22.5"", ""title"": ""MetaCyc 4-aminobenzoate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-6543&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6543_edge-012_aa4c85c763c6	UniProtKB:P00903	pathwaymech:enables	RHEA:11673	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00903		"[{""reference_id"": ""UniProtKB:P00903"", ""source_assertion"": ""UniProt annotates UniProtKB:P00903 with catalytic activity for the reaction family of RHEA:11673. Annotation evidence: ECO:0000269, ECO:0000305; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00903"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00903 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00903.json""}]"	""
pathwaymech:MetaCyc_PWY-6543_edge-013_d58b6df5a5b3	UniProtKB:P05041	pathwaymech:enables	RHEA:11673	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05041		"[{""reference_id"": ""UniProtKB:P05041"", ""source_assertion"": ""UniProt annotates UniProtKB:P05041 with catalytic activity for the reaction family of RHEA:11673. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P05041"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05041 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05041.json""}]"	""
pathwaymech:MetaCyc_PWY-6543_edge-014_c4094495a8f3	UniProtKB:P05041	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05041		"[{""reference_id"": ""UniProtKB:P05041"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P05041 (evidence: ECO:0000269). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P05041"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05041 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05041.json""}]"	""
pathwaymech:MetaCyc_PWY-6543_edge-015_38b0040c1ccf	UniProtKB:P28305	pathwaymech:enables	RHEA:16202	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P28305		"[{""reference_id"": ""UniProtKB:P28305"", ""source_assertion"": ""UniProt annotates UniProtKB:P28305 with catalytic activity for the reaction family of RHEA:16202. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P28305"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P28305 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P28305.json""}]"	""
pathwaymech:MetaCyc_PWY-6543_edge-016_fb8ff16246b3	UniProtKB:P28305	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P28305		"[{""reference_id"": ""UniProtKB:P28305"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P28305 (evidence: ECO:0000269). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P28305"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P28305 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P28305.json""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_edge-001_8545f62b9127	gomodel:RXN0-5293	RO:0002233	CHEBI:13390	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-5293 RO:0002233 gomodel:CHEBI_13390_RXN0-5293."", ""source_locator"": ""./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/0; endpoint types: /individuals/10/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-04-22; member ./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json"", ""title"": ""SGD GO-CAM 4-aminobutyrate degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_edge-002_5d61a5821e2b	gomodel:RXN0-5293	RO:0002234	CHEBI:30031	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-5293 RO:0002234 gomodel:CHEBI_30031_RXN0-5293."", ""source_locator"": ""./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/1; endpoint types: /individuals/10/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-04-22; member ./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json"", ""title"": ""SGD GO-CAM 4-aminobutyrate degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_edge-003_c7b4009c2958	gomodel:GABATRANSAM-RXN	RO:0002233	CHEBI:59888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GABATRANSAM-RXN RO:0002233 gomodel:CHEBI_59888_GABATRANSAM-RXN."", ""source_locator"": ""./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/2; endpoint types: /individuals/9/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-04-22; member ./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json"", ""title"": ""SGD GO-CAM 4-aminobutyrate degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_edge-004_2e0ee7ed0acf	gomodel:GABATRANSAM-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GABATRANSAM-RXN BFO:0000066 gomodel:reaction_GABATRANSAM-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/3; endpoint types: /individuals/9/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-04-22; member ./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json"", ""title"": ""SGD GO-CAM 4-aminobutyrate degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_edge-005_502510e8ff0d	gomodel:RXN0-5293	BFO:0000050	GO:0006540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-5293 BFO:0000050 gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY/YeastPathways_YEAST-4AMINOBUTMETAB-PWY."", ""source_locator"": ""./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/4; endpoint types: /individuals/10/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-04-22; member ./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json"", ""title"": ""SGD GO-CAM 4-aminobutyrate degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_edge-006_060801b6943d	gomodel:RXN0-5293	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-5293 BFO:0000066 gomodel:reaction_RXN0-5293_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/5; endpoint types: /individuals/10/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-04-22; member ./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json"", ""title"": ""SGD GO-CAM 4-aminobutyrate degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_edge-007_0eb3f56d3015	gomodel:GABATRANSAM-RXN	RO:0002234	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GABATRANSAM-RXN RO:0002234 gomodel:CHEBI_29985_GABATRANSAM-RXN."", ""source_locator"": ""./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/6; endpoint types: /individuals/9/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-04-22; member ./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json"", ""title"": ""SGD GO-CAM 4-aminobutyrate degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_edge-008_a20c512d0a5d	gomodel:RXN0-5293	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-5293 RO:0002234 gomodel:CHEBI_15378_RXN0-5293."", ""source_locator"": ""./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/7; endpoint types: /individuals/10/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-04-22; member ./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json"", ""title"": ""SGD GO-CAM 4-aminobutyrate degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_edge-009_ad5846b0adfe	gomodel:RXN0-5293	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-5293 RO:0002233 gomodel:CHEBI_15377_RXN0-5293."", ""source_locator"": ""./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/8; endpoint types: /individuals/10/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-04-22; member ./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json"", ""title"": ""SGD GO-CAM 4-aminobutyrate degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_edge-010_a74cc1e285e0	SGD:S000000210	pathwaymech:enables	gomodel:RXN0-5293	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-5293 RO:0002333 gomodel:YBR006W-MONOMER_RXN0-5293_controller."", ""source_locator"": ""./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/9; endpoint types: /individuals/10/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-04-22; member ./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json"", ""title"": ""SGD GO-CAM 4-aminobutyrate degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_edge-011_35e1eebf3ca8	gomodel:GABATRANSAM-RXN	RO:0002234	CHEBI:57706	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GABATRANSAM-RXN RO:0002234 gomodel:CHEBI_57706_GABATRANSAM-RXN."", ""source_locator"": ""./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/10; endpoint types: /individuals/9/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-04-22; member ./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json"", ""title"": ""SGD GO-CAM 4-aminobutyrate degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_edge-012_b68641a09404	gomodel:RXN0-5293	RO:0002234	CHEBI:13392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-5293 RO:0002234 gomodel:CHEBI_13392_RXN0-5293."", ""source_locator"": ""./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/11; endpoint types: /individuals/10/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-04-22; member ./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json"", ""title"": ""SGD GO-CAM 4-aminobutyrate degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_edge-013_75124b3ef80a	gomodel:GABATRANSAM-RXN	BFO:0000050	GO:0006540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GABATRANSAM-RXN BFO:0000050 gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY/YeastPathways_YEAST-4AMINOBUTMETAB-PWY."", ""source_locator"": ""./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/12; endpoint types: /individuals/9/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-04-22; member ./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json"", ""title"": ""SGD GO-CAM 4-aminobutyrate degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_edge-014_e9d8e2cf2705	SGD:S000003251	pathwaymech:enables	gomodel:GABATRANSAM-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GABATRANSAM-RXN RO:0002333 gomodel:YGR019W-MONOMER_GABATRANSAM-RXN_controller."", ""source_locator"": ""./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/13; endpoint types: /individuals/9/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-04-22; member ./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json"", ""title"": ""SGD GO-CAM 4-aminobutyrate degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_edge-015_15568efe3d07	gomodel:RXN0-5293	RO:0002233	CHEBI:57706	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-5293 RO:0002233 gomodel:CHEBI_57706_GABATRANSAM-RXN."", ""source_locator"": ""./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/14; endpoint types: /individuals/10/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-04-22; member ./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json"", ""title"": ""SGD GO-CAM 4-aminobutyrate degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_edge-016_c7c916a9d5f4	gomodel:GABATRANSAM-RXN	RO:0002233	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GABATRANSAM-RXN RO:0002233 gomodel:CHEBI_16810_GABATRANSAM-RXN."", ""source_locator"": ""./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/15; endpoint types: /individuals/9/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-04-22; member ./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json"", ""title"": ""SGD GO-CAM 4-aminobutyrate degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_location-d97108800b33_74d0bda1f46c	SGD:S000000210	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38067	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38067"", ""source_assertion"": ""UniProtKB:P38067 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1267/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38067"", ""source_assertion"": ""UniProtKB:P38067 has the exact SGD cross-reference SGD:S000000210."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1267/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38067"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38067 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_location-100b2602f60f_631c51ac6c9b	SGD:S000003251	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P17649	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11914276)	"[{""reference_id"": ""UniProtKB:P17649"", ""source_assertion"": ""UniProtKB:P17649 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/468/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P17649"", ""source_assertion"": ""UniProtKB:P17649 has the exact SGD cross-reference SGD:S000003251."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/468/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P17649"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P17649 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-4AMINOBUTMETAB-PWY_cofactor-2a5c0a452713_22fb1892b1df	SGD:S000003251	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P17649	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:17355287)	"[{""reference_id"": ""UniProtKB:P17649"", ""source_assertion"": ""UniProtKB:P17649 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/468/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P17649"", ""source_assertion"": ""UniProtKB:P17649 has the exact SGD cross-reference SGD:S000003251."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/468/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P17649"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P17649 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-001_884597e6806c	CHEBI:15377	pathwaymech:consumes	RHEA:14907	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14907		"[{""reference_id"": ""RHEA:14907"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:14907 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14907']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14907"", ""source_version"": ""139"", ""title"": ""Rhea 5-phospho-beta-D-ribosylamine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14907""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-002_d3670b5ebd69	CHEBI:58017	pathwaymech:consumes	RHEA:14907	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14907		"[{""reference_id"": ""RHEA:14907"", ""source_assertion"": ""Rhea lists CHEBI:58017 on the substrates side of RHEA:14907 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14907']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14907"", ""source_version"": ""139"", ""title"": ""Rhea 5-phospho-beta-D-ribosylamine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14907""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-003_7bce87ceba5a	CHEBI:58359	pathwaymech:consumes	RHEA:14907	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14907		"[{""reference_id"": ""RHEA:14907"", ""source_assertion"": ""Rhea lists CHEBI:58359 on the substrates side of RHEA:14907 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14907']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14907"", ""source_version"": ""139"", ""title"": ""Rhea 5-phospho-beta-D-ribosylamine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14907""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-004_3d611bf1183e	RHEA:14907	pathwaymech:produces	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14907		"[{""reference_id"": ""RHEA:14907"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the products side of RHEA:14907 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14907']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14907"", ""source_version"": ""139"", ""title"": ""Rhea 5-phospho-beta-D-ribosylamine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14907""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-005_4ecf75c25abe	RHEA:14907	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14907		"[{""reference_id"": ""RHEA:14907"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:14907 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14907']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14907"", ""source_version"": ""139"", ""title"": ""Rhea 5-phospho-beta-D-ribosylamine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14907""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-006_a2a6098a0f44	RHEA:14907	pathwaymech:produces	CHEBI:58681	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14907		"[{""reference_id"": ""RHEA:14907"", ""source_assertion"": ""Rhea lists CHEBI:58681 on the products side of RHEA:14907 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14907']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14907"", ""source_version"": ""139"", ""title"": ""Rhea 5-phospho-beta-D-ribosylamine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14907""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-007_e75f8840f0ed	CHEBI:30616	pathwaymech:consumes	RHEA:17454	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17454		"[{""reference_id"": ""RHEA:17454"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:17454 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17454']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17454"", ""source_version"": ""139"", ""title"": ""Rhea glycinamide ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17454""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-008_94bccaad635a	CHEBI:57305	pathwaymech:consumes	RHEA:17454	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17454		"[{""reference_id"": ""RHEA:17454"", ""source_assertion"": ""Rhea lists CHEBI:57305 on the substrates side of RHEA:17454 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17454']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17454"", ""source_version"": ""139"", ""title"": ""Rhea glycinamide ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17454""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-009_398b98c984b4	CHEBI:58681	pathwaymech:consumes	RHEA:17454	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17454		"[{""reference_id"": ""RHEA:17454"", ""source_assertion"": ""Rhea lists CHEBI:58681 on the substrates side of RHEA:17454 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17454']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17454"", ""source_version"": ""139"", ""title"": ""Rhea glycinamide ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17454""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-010_95292cb1c569	RHEA:17454	pathwaymech:produces	CHEBI:143788	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17454		"[{""reference_id"": ""RHEA:17454"", ""source_assertion"": ""Rhea lists CHEBI:143788 on the products side of RHEA:17454 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17454']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17454"", ""source_version"": ""139"", ""title"": ""Rhea glycinamide ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17454""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-011_6f0a9bede735	RHEA:17454	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17454		"[{""reference_id"": ""RHEA:17454"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:17454 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17454']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17454"", ""source_version"": ""139"", ""title"": ""Rhea glycinamide ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17454""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-012_1a9edc5cec86	RHEA:17454	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17454		"[{""reference_id"": ""RHEA:17454"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:17454 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17454']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17454"", ""source_version"": ""139"", ""title"": ""Rhea glycinamide ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17454""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-013_0827ce6c9241	RHEA:17454	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17454		"[{""reference_id"": ""RHEA:17454"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:17454 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17454']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17454"", ""source_version"": ""139"", ""title"": ""Rhea glycinamide ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17454""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-014_2d1e340ba76f	CHEBI:143788	pathwaymech:consumes	RHEA:15054	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15054		"[{""reference_id"": ""RHEA:15054"", ""source_assertion"": ""Rhea lists CHEBI:143788 on the substrates side of RHEA:15054 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15054']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15054"", ""source_version"": ""139"", ""title"": ""Rhea FGAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15054""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-015_1f3056f588a0	CHEBI:195366	pathwaymech:consumes	RHEA:15054	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15054		"[{""reference_id"": ""RHEA:15054"", ""source_assertion"": ""Rhea lists CHEBI:195366 on the substrates side of RHEA:15054 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15054']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15054"", ""source_version"": ""139"", ""title"": ""Rhea FGAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15054""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-016_a257ca8de6dc	RHEA:15054	pathwaymech:produces	CHEBI:147286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15054		"[{""reference_id"": ""RHEA:15054"", ""source_assertion"": ""Rhea lists CHEBI:147286 on the products side of RHEA:15054 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15054']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15054"", ""source_version"": ""139"", ""title"": ""Rhea FGAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15054""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-017_5c50d8a94066	RHEA:15054	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15054		"[{""reference_id"": ""RHEA:15054"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:15054 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15054']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15054"", ""source_version"": ""139"", ""title"": ""Rhea FGAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15054""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-018_4ceed4de2cc3	RHEA:15054	pathwaymech:produces	CHEBI:57453	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15054		"[{""reference_id"": ""RHEA:15054"", ""source_assertion"": ""Rhea lists CHEBI:57453 on the products side of RHEA:15054 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15054']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15054"", ""source_version"": ""139"", ""title"": ""Rhea FGAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15054""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-019_11ed4376e91d	CHEBI:147286	pathwaymech:consumes	RHEA:17130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17130		"[{""reference_id"": ""RHEA:17130"", ""source_assertion"": ""Rhea lists CHEBI:147286 on the substrates side of RHEA:17130 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17130']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17130"", ""source_version"": ""139"", ""title"": ""Rhea FGAM-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17130""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-020_16d6e29a86ff	CHEBI:15377	pathwaymech:consumes	RHEA:17130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17130		"[{""reference_id"": ""RHEA:17130"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:17130 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17130']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17130"", ""source_version"": ""139"", ""title"": ""Rhea FGAM-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17130""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-021_722bbc237080	CHEBI:30616	pathwaymech:consumes	RHEA:17130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17130		"[{""reference_id"": ""RHEA:17130"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:17130 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17130']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17130"", ""source_version"": ""139"", ""title"": ""Rhea FGAM-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17130""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-022_2f679d23d3d4	CHEBI:58359	pathwaymech:consumes	RHEA:17130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17130		"[{""reference_id"": ""RHEA:17130"", ""source_assertion"": ""Rhea lists CHEBI:58359 on the substrates side of RHEA:17130 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17130']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17130"", ""source_version"": ""139"", ""title"": ""Rhea FGAM-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17130""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-023_464d79926f7a	RHEA:17130	pathwaymech:produces	CHEBI:147287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17130		"[{""reference_id"": ""RHEA:17130"", ""source_assertion"": ""Rhea lists CHEBI:147287 on the products side of RHEA:17130 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17130']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17130"", ""source_version"": ""139"", ""title"": ""Rhea FGAM-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17130""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-024_c918481a7b69	RHEA:17130	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17130		"[{""reference_id"": ""RHEA:17130"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:17130 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17130']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17130"", ""source_version"": ""139"", ""title"": ""Rhea FGAM-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17130""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-025_9d1f7824561a	RHEA:17130	pathwaymech:produces	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17130		"[{""reference_id"": ""RHEA:17130"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the products side of RHEA:17130 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17130']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17130"", ""source_version"": ""139"", ""title"": ""Rhea FGAM-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17130""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-026_140a71904969	RHEA:17130	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17130		"[{""reference_id"": ""RHEA:17130"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:17130 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17130']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17130"", ""source_version"": ""139"", ""title"": ""Rhea FGAM-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17130""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-027_03a4849ad7ea	RHEA:17130	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17130		"[{""reference_id"": ""RHEA:17130"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:17130 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17130']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17130"", ""source_version"": ""139"", ""title"": ""Rhea FGAM-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17130""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-028_c053205f3592	CHEBI:147287	pathwaymech:consumes	RHEA:23033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23033		"[{""reference_id"": ""RHEA:23033"", ""source_assertion"": ""Rhea lists CHEBI:147287 on the substrates side of RHEA:23033 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23033']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23033"", ""source_version"": ""139"", ""title"": ""Rhea AIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23033""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-029_b7a556c10117	CHEBI:30616	pathwaymech:consumes	RHEA:23033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23033		"[{""reference_id"": ""RHEA:23033"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:23033 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23033']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23033"", ""source_version"": ""139"", ""title"": ""Rhea AIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23033""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-030_02482849a22b	RHEA:23033	pathwaymech:produces	CHEBI:137981	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23033		"[{""reference_id"": ""RHEA:23033"", ""source_assertion"": ""Rhea lists CHEBI:137981 on the products side of RHEA:23033 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23033']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23033"", ""source_version"": ""139"", ""title"": ""Rhea AIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23033""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-031_f713c0b3d140	RHEA:23033	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23033		"[{""reference_id"": ""RHEA:23033"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:23033 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23033']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23033"", ""source_version"": ""139"", ""title"": ""Rhea AIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23033""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-032_950b657e76c4	RHEA:23033	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23033		"[{""reference_id"": ""RHEA:23033"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:23033 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23033']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23033"", ""source_version"": ""139"", ""title"": ""Rhea AIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23033""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-033_2016df3ad1df	RHEA:23033	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23033		"[{""reference_id"": ""RHEA:23033"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:23033 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23033']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23033"", ""source_version"": ""139"", ""title"": ""Rhea AIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23033""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-034_fd632132f542	EC:2.4.2.14	pathwaymech:catalyzes	RHEA:14907	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14905		"[{""reference_id"": ""RHEA:14905"", ""source_assertion"": ""Rhea associates EC:2.4.2.14 with the reaction family containing RHEA:14907."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:14905"", ""source_version"": ""139"", ""title"": ""Rhea amidophosphoribosyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/14905""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-035_df678191db78	EC:6.3.4.13	pathwaymech:catalyzes	RHEA:17454	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17453		"[{""reference_id"": ""RHEA:17453"", ""source_assertion"": ""Rhea associates EC:6.3.4.13 with the reaction family containing RHEA:17454."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:17453"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosylamine-glycine ligase reaction"", ""url"": ""https://www.rhea-db.org/rhea/17453""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-036_2bbeec663e6a	EC:2.1.2.2	pathwaymech:catalyzes	RHEA:15054	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15053		"[{""reference_id"": ""RHEA:15053"", ""source_assertion"": ""Rhea associates EC:2.1.2.2 with the reaction family containing RHEA:15054."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:15053"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosylglycinamide formyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/15053""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-037_8a9b2e4c0d1a	EC:6.3.5.3	pathwaymech:catalyzes	RHEA:17130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17129		"[{""reference_id"": ""RHEA:17129"", ""source_assertion"": ""Rhea associates EC:6.3.5.3 with the reaction family containing RHEA:17130."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:17129"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosylformylglycinamidine synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/17129""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-038_eca414e3e4b5	EC:6.3.3.1	pathwaymech:catalyzes	RHEA:23033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23032		"[{""reference_id"": ""RHEA:23032"", ""source_assertion"": ""Rhea associates EC:6.3.3.1 with the reaction family containing RHEA:23033."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:23032"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosylformylglycinamidine cyclo-ligase reaction"", ""url"": ""https://www.rhea-db.org/rhea/23032""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-039_eedbd5cb80b9	RHEA:14907	pathwaymech:precedes	RHEA:17454	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6121		"[{""reference_id"": ""MetaCyc:PWY-6121"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:14907 before RHEA:17454 in this pathway. Shared intermediate: CHEBI:58681."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-6121"", ""source_sha256"": ""bcda9cef54acab3f23012706e143a75a58832cf6f38098d775ca07e1d91f5682"", ""source_version"": ""22.5"", ""title"": ""MetaCyc 5-aminoimidazole ribonucleotide biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-6121&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-040_331c85006e66	RHEA:15054	pathwaymech:precedes	RHEA:17130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6121		"[{""reference_id"": ""MetaCyc:PWY-6121"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:15054 before RHEA:17130 in this pathway. Shared intermediate: CHEBI:147286."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-6121"", ""source_sha256"": ""bcda9cef54acab3f23012706e143a75a58832cf6f38098d775ca07e1d91f5682"", ""source_version"": ""22.5"", ""title"": ""MetaCyc 5-aminoimidazole ribonucleotide biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-6121&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-041_275c8afe9711	RHEA:17130	pathwaymech:precedes	RHEA:23033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6121		"[{""reference_id"": ""MetaCyc:PWY-6121"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:17130 before RHEA:23033 in this pathway. Shared intermediate: CHEBI:147287."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-6121"", ""source_sha256"": ""bcda9cef54acab3f23012706e143a75a58832cf6f38098d775ca07e1d91f5682"", ""source_version"": ""22.5"", ""title"": ""MetaCyc 5-aminoimidazole ribonucleotide biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-6121&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-042_f56e06286eb5	RHEA:17454	pathwaymech:precedes	RHEA:15054	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6121		"[{""reference_id"": ""MetaCyc:PWY-6121"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:17454 before RHEA:15054 in this pathway. Shared intermediate: CHEBI:143788."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-6121"", ""source_sha256"": ""bcda9cef54acab3f23012706e143a75a58832cf6f38098d775ca07e1d91f5682"", ""source_version"": ""22.5"", ""title"": ""MetaCyc 5-aminoimidazole ribonucleotide biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-6121&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-043_c8485e2474c2	UniProtKB:P08178	pathwaymech:enables	RHEA:23033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08178		"[{""reference_id"": ""UniProtKB:P08178"", ""source_assertion"": ""UniProt annotates UniProtKB:P08178 with catalytic activity for the reaction family of RHEA:23033. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P08178"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P08178 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08178.json""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-044_4559d336234b	UniProtKB:P08178	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08178		"[{""reference_id"": ""UniProtKB:P08178"", ""source_assertion"": ""UniProt locates UniProtKB:P08178 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P08178"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P08178 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08178.json""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-045_98229de158c7	UniProtKB:P08179	pathwaymech:enables	RHEA:15054	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08179		"[{""reference_id"": ""UniProtKB:P08179"", ""source_assertion"": ""UniProt annotates UniProtKB:P08179 with catalytic activity for the reaction family of RHEA:15054. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P08179"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P08179 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08179.json""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-046_45460bda0a49	UniProtKB:P0AG16	pathwaymech:enables	RHEA:14907	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AG16		"[{""reference_id"": ""UniProtKB:P0AG16"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AG16 with catalytic activity for the reaction family of RHEA:14907. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AG16"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AG16 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AG16.json""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-047_1ae75e14d28a	UniProtKB:P0AG16	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AG16		"[{""reference_id"": ""UniProtKB:P0AG16"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P0AG16 (evidence: ECO:0000255). Binds 1 Mg(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AG16"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AG16 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AG16.json""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-048_a6b5d65a7cc2	UniProtKB:P15254	pathwaymech:enables	RHEA:17130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15254		"[{""reference_id"": ""UniProtKB:P15254"", ""source_assertion"": ""UniProt annotates UniProtKB:P15254 with catalytic activity for the reaction family of RHEA:17130. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P15254"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P15254 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P15254.json""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-049_9013862eac9a	UniProtKB:P15254	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15254		"[{""reference_id"": ""UniProtKB:P15254"", ""source_assertion"": ""UniProt locates UniProtKB:P15254 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255, ECO:0000269."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P15254"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P15254 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P15254.json""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-050_61d9afc3aff0	UniProtKB:P15640	pathwaymech:enables	RHEA:17454	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15640		"[{""reference_id"": ""UniProtKB:P15640"", ""source_assertion"": ""UniProt annotates UniProtKB:P15640 with catalytic activity for the reaction family of RHEA:17454. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P15640"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P15640 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P15640.json""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-051_16e21d16a4e6	UniProtKB:P15640	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15640		"[{""reference_id"": ""UniProtKB:P15640"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P15640 (evidence: ECO:0000269). Binds 1 Mg(2+) or Mn(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P15640"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P15640 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P15640.json""}]"	""
pathwaymech:MetaCyc_PWY-6121_edge-052_28c4fb11bf42	UniProtKB:P15640	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15640		"[{""reference_id"": ""UniProtKB:P15640"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P15640 (evidence: ECO:0000250). Binds 1 Mg(2+) or Mn(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P15640"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P15640 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P15640.json""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-001_51f0ca1ff55e	CHEBI:15377	pathwaymech:consumes	RHEA:14907	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14907		"[{""reference_id"": ""RHEA:14907"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:14907 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14907']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14907"", ""source_version"": ""139"", ""title"": ""Rhea 5-phospho-beta-D-ribosylamine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14907""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-002_8cb7709ba0a9	CHEBI:58017	pathwaymech:consumes	RHEA:14907	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14907		"[{""reference_id"": ""RHEA:14907"", ""source_assertion"": ""Rhea lists CHEBI:58017 on the substrates side of RHEA:14907 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14907']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14907"", ""source_version"": ""139"", ""title"": ""Rhea 5-phospho-beta-D-ribosylamine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14907""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-003_a5fe868d2cca	CHEBI:58359	pathwaymech:consumes	RHEA:14907	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14907		"[{""reference_id"": ""RHEA:14907"", ""source_assertion"": ""Rhea lists CHEBI:58359 on the substrates side of RHEA:14907 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14907']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14907"", ""source_version"": ""139"", ""title"": ""Rhea 5-phospho-beta-D-ribosylamine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14907""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-004_2d7a8aedb1a4	RHEA:14907	pathwaymech:produces	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14907		"[{""reference_id"": ""RHEA:14907"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the products side of RHEA:14907 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14907']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14907"", ""source_version"": ""139"", ""title"": ""Rhea 5-phospho-beta-D-ribosylamine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14907""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-005_eb876f7d5531	RHEA:14907	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14907		"[{""reference_id"": ""RHEA:14907"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:14907 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14907']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14907"", ""source_version"": ""139"", ""title"": ""Rhea 5-phospho-beta-D-ribosylamine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14907""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-006_d4c720c68a65	RHEA:14907	pathwaymech:produces	CHEBI:58681	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14907		"[{""reference_id"": ""RHEA:14907"", ""source_assertion"": ""Rhea lists CHEBI:58681 on the products side of RHEA:14907 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14907']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14907"", ""source_version"": ""139"", ""title"": ""Rhea 5-phospho-beta-D-ribosylamine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14907""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-007_ab10ca47fd49	CHEBI:30616	pathwaymech:consumes	RHEA:17454	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17454		"[{""reference_id"": ""RHEA:17454"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:17454 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17454']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17454"", ""source_version"": ""139"", ""title"": ""Rhea glycinamide ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17454""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-008_9165a4401b46	CHEBI:57305	pathwaymech:consumes	RHEA:17454	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17454		"[{""reference_id"": ""RHEA:17454"", ""source_assertion"": ""Rhea lists CHEBI:57305 on the substrates side of RHEA:17454 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17454']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17454"", ""source_version"": ""139"", ""title"": ""Rhea glycinamide ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17454""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-009_1c71de413fc8	CHEBI:58681	pathwaymech:consumes	RHEA:17454	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17454		"[{""reference_id"": ""RHEA:17454"", ""source_assertion"": ""Rhea lists CHEBI:58681 on the substrates side of RHEA:17454 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17454']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17454"", ""source_version"": ""139"", ""title"": ""Rhea glycinamide ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17454""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-010_cbe56626ee2e	RHEA:17454	pathwaymech:produces	CHEBI:143788	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17454		"[{""reference_id"": ""RHEA:17454"", ""source_assertion"": ""Rhea lists CHEBI:143788 on the products side of RHEA:17454 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17454']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17454"", ""source_version"": ""139"", ""title"": ""Rhea glycinamide ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17454""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-011_641cd06e0c3e	RHEA:17454	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17454		"[{""reference_id"": ""RHEA:17454"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:17454 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17454']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17454"", ""source_version"": ""139"", ""title"": ""Rhea glycinamide ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17454""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-012_e30666485915	RHEA:17454	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17454		"[{""reference_id"": ""RHEA:17454"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:17454 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17454']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17454"", ""source_version"": ""139"", ""title"": ""Rhea glycinamide ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17454""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-013_95ad8f26e396	RHEA:17454	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17454		"[{""reference_id"": ""RHEA:17454"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:17454 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17454']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17454"", ""source_version"": ""139"", ""title"": ""Rhea glycinamide ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17454""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-014_f0bd804b12df	CHEBI:143788	pathwaymech:consumes	RHEA:24830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24830		"[{""reference_id"": ""RHEA:24830"", ""source_assertion"": ""Rhea lists CHEBI:143788 on the substrates side of RHEA:24830 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24830']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24830"", ""source_version"": ""139"", ""title"": ""Rhea FGAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24830""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-015_084ddec7128c	CHEBI:15740	pathwaymech:consumes	RHEA:24830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24830		"[{""reference_id"": ""RHEA:24830"", ""source_assertion"": ""Rhea lists CHEBI:15740 on the substrates side of RHEA:24830 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24830']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24830"", ""source_version"": ""139"", ""title"": ""Rhea FGAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24830""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-016_6a9e177ca372	CHEBI:30616	pathwaymech:consumes	RHEA:24830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24830		"[{""reference_id"": ""RHEA:24830"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:24830 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24830']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24830"", ""source_version"": ""139"", ""title"": ""Rhea FGAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24830""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-017_ce5c6535660e	RHEA:24830	pathwaymech:produces	CHEBI:147286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24830		"[{""reference_id"": ""RHEA:24830"", ""source_assertion"": ""Rhea lists CHEBI:147286 on the products side of RHEA:24830 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24830']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24830"", ""source_version"": ""139"", ""title"": ""Rhea FGAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24830""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-018_4fb3002cc8a1	RHEA:24830	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24830		"[{""reference_id"": ""RHEA:24830"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:24830 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24830']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24830"", ""source_version"": ""139"", ""title"": ""Rhea FGAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24830""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-019_b94faf7c5cd0	RHEA:24830	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24830		"[{""reference_id"": ""RHEA:24830"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:24830 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24830']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24830"", ""source_version"": ""139"", ""title"": ""Rhea FGAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24830""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-020_9e8a99a4a22f	RHEA:24830	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24830		"[{""reference_id"": ""RHEA:24830"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:24830 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24830']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24830"", ""source_version"": ""139"", ""title"": ""Rhea FGAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24830""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-021_354013f7c503	CHEBI:147286	pathwaymech:consumes	RHEA:17130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17130		"[{""reference_id"": ""RHEA:17130"", ""source_assertion"": ""Rhea lists CHEBI:147286 on the substrates side of RHEA:17130 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17130']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17130"", ""source_version"": ""139"", ""title"": ""Rhea FGAM-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17130""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-022_07d83172c8d8	CHEBI:15377	pathwaymech:consumes	RHEA:17130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17130		"[{""reference_id"": ""RHEA:17130"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:17130 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17130']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17130"", ""source_version"": ""139"", ""title"": ""Rhea FGAM-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17130""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-023_c1d25a1f7b61	CHEBI:30616	pathwaymech:consumes	RHEA:17130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17130		"[{""reference_id"": ""RHEA:17130"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:17130 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17130']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17130"", ""source_version"": ""139"", ""title"": ""Rhea FGAM-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17130""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-024_3dbcc8f6f94f	CHEBI:58359	pathwaymech:consumes	RHEA:17130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17130		"[{""reference_id"": ""RHEA:17130"", ""source_assertion"": ""Rhea lists CHEBI:58359 on the substrates side of RHEA:17130 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17130']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17130"", ""source_version"": ""139"", ""title"": ""Rhea FGAM-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17130""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-025_35b8e8a3ca91	RHEA:17130	pathwaymech:produces	CHEBI:147287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17130		"[{""reference_id"": ""RHEA:17130"", ""source_assertion"": ""Rhea lists CHEBI:147287 on the products side of RHEA:17130 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17130']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17130"", ""source_version"": ""139"", ""title"": ""Rhea FGAM-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17130""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-026_87d3e6d032ba	RHEA:17130	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17130		"[{""reference_id"": ""RHEA:17130"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:17130 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17130']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17130"", ""source_version"": ""139"", ""title"": ""Rhea FGAM-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17130""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-027_d2cbe97186fb	RHEA:17130	pathwaymech:produces	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17130		"[{""reference_id"": ""RHEA:17130"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the products side of RHEA:17130 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17130']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17130"", ""source_version"": ""139"", ""title"": ""Rhea FGAM-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17130""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-028_d64e6d11a85c	RHEA:17130	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17130		"[{""reference_id"": ""RHEA:17130"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:17130 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17130']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17130"", ""source_version"": ""139"", ""title"": ""Rhea FGAM-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17130""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-029_f3832bfd1121	RHEA:17130	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17130		"[{""reference_id"": ""RHEA:17130"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:17130 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17130']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17130"", ""source_version"": ""139"", ""title"": ""Rhea FGAM-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17130""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-030_c653146ef6ad	CHEBI:147287	pathwaymech:consumes	RHEA:23033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23033		"[{""reference_id"": ""RHEA:23033"", ""source_assertion"": ""Rhea lists CHEBI:147287 on the substrates side of RHEA:23033 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23033']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23033"", ""source_version"": ""139"", ""title"": ""Rhea AIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23033""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-031_478d30a804b7	CHEBI:30616	pathwaymech:consumes	RHEA:23033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23033		"[{""reference_id"": ""RHEA:23033"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:23033 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23033']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23033"", ""source_version"": ""139"", ""title"": ""Rhea AIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23033""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-032_e7eafaff9f54	RHEA:23033	pathwaymech:produces	CHEBI:137981	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23033		"[{""reference_id"": ""RHEA:23033"", ""source_assertion"": ""Rhea lists CHEBI:137981 on the products side of RHEA:23033 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23033']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23033"", ""source_version"": ""139"", ""title"": ""Rhea AIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23033""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-033_9cf1878eaf1b	RHEA:23033	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23033		"[{""reference_id"": ""RHEA:23033"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:23033 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23033']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23033"", ""source_version"": ""139"", ""title"": ""Rhea AIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23033""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-034_f6adf8a5fa96	RHEA:23033	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23033		"[{""reference_id"": ""RHEA:23033"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:23033 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23033']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23033"", ""source_version"": ""139"", ""title"": ""Rhea AIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23033""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-035_861a2166f533	RHEA:23033	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23033		"[{""reference_id"": ""RHEA:23033"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:23033 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23033']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23033"", ""source_version"": ""139"", ""title"": ""Rhea AIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23033""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-036_9ceaac7f8d9e	EC:2.4.2.14	pathwaymech:catalyzes	RHEA:14907	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14905		"[{""reference_id"": ""RHEA:14905"", ""source_assertion"": ""Rhea associates EC:2.4.2.14 with the reaction family containing RHEA:14907."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:14905"", ""source_version"": ""139"", ""title"": ""Rhea amidophosphoribosyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/14905""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-037_18950b6b901b	EC:6.3.4.13	pathwaymech:catalyzes	RHEA:17454	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17453		"[{""reference_id"": ""RHEA:17453"", ""source_assertion"": ""Rhea associates EC:6.3.4.13 with the reaction family containing RHEA:17454."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:17453"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosylamine-glycine ligase reaction"", ""url"": ""https://www.rhea-db.org/rhea/17453""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-038_c656d0defdb1	EC:6.3.1.21	pathwaymech:catalyzes	RHEA:24830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24829		"[{""reference_id"": ""RHEA:24829"", ""source_assertion"": ""Rhea associates EC:6.3.1.21 with the reaction family containing RHEA:24830."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:24829"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosylglycinamide formyltransferase 2 reaction"", ""url"": ""https://www.rhea-db.org/rhea/24829""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-039_eda2b9227902	EC:6.3.5.3	pathwaymech:catalyzes	RHEA:17130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17129		"[{""reference_id"": ""RHEA:17129"", ""source_assertion"": ""Rhea associates EC:6.3.5.3 with the reaction family containing RHEA:17130."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:17129"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosylformylglycinamidine synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/17129""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-040_b2317d1712f9	EC:6.3.3.1	pathwaymech:catalyzes	RHEA:23033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23032		"[{""reference_id"": ""RHEA:23032"", ""source_assertion"": ""Rhea associates EC:6.3.3.1 with the reaction family containing RHEA:23033."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:23032"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosylformylglycinamidine cyclo-ligase reaction"", ""url"": ""https://www.rhea-db.org/rhea/23032""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-041_3bc7fa84e571	RHEA:14907	pathwaymech:precedes	RHEA:17454	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6122		"[{""reference_id"": ""MetaCyc:PWY-6122"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:14907 before RHEA:17454 in this pathway. Shared intermediate: CHEBI:58681."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-6122"", ""source_sha256"": ""0271a6606bafa741010589c312ef78df23c75def65fddb5d678a4e489262f205"", ""source_version"": ""22.5"", ""title"": ""MetaCyc 5-aminoimidazole ribonucleotide biosynthesis II pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-6122&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-042_43c76f485ee4	RHEA:17130	pathwaymech:precedes	RHEA:23033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6122		"[{""reference_id"": ""MetaCyc:PWY-6122"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:17130 before RHEA:23033 in this pathway. Shared intermediate: CHEBI:147287."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-6122"", ""source_sha256"": ""0271a6606bafa741010589c312ef78df23c75def65fddb5d678a4e489262f205"", ""source_version"": ""22.5"", ""title"": ""MetaCyc 5-aminoimidazole ribonucleotide biosynthesis II pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-6122&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-043_bacc65ee5029	RHEA:17454	pathwaymech:precedes	RHEA:24830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6122		"[{""reference_id"": ""MetaCyc:PWY-6122"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:17454 before RHEA:24830 in this pathway. Shared intermediate: CHEBI:143788."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-6122"", ""source_sha256"": ""0271a6606bafa741010589c312ef78df23c75def65fddb5d678a4e489262f205"", ""source_version"": ""22.5"", ""title"": ""MetaCyc 5-aminoimidazole ribonucleotide biosynthesis II pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-6122&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-044_40cd9182808e	RHEA:24830	pathwaymech:precedes	RHEA:17130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6122		"[{""reference_id"": ""MetaCyc:PWY-6122"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:24830 before RHEA:17130 in this pathway. Shared intermediate: CHEBI:147286."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-6122"", ""source_sha256"": ""0271a6606bafa741010589c312ef78df23c75def65fddb5d678a4e489262f205"", ""source_version"": ""22.5"", ""title"": ""MetaCyc 5-aminoimidazole ribonucleotide biosynthesis II pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-6122&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-045_e00adea2cbc9	UniProtKB:P08178	pathwaymech:enables	RHEA:23033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08178		"[{""reference_id"": ""UniProtKB:P08178"", ""source_assertion"": ""UniProt annotates UniProtKB:P08178 with catalytic activity for the reaction family of RHEA:23033. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P08178"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P08178 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08178.json""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-046_d9985c27e26d	UniProtKB:P08178	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08178		"[{""reference_id"": ""UniProtKB:P08178"", ""source_assertion"": ""UniProt locates UniProtKB:P08178 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P08178"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P08178 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08178.json""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-047_9bbca5f76959	UniProtKB:P0AG16	pathwaymech:enables	RHEA:14907	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AG16		"[{""reference_id"": ""UniProtKB:P0AG16"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AG16 with catalytic activity for the reaction family of RHEA:14907. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AG16"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AG16 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AG16.json""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-048_75d56d327068	UniProtKB:P0AG16	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AG16		"[{""reference_id"": ""UniProtKB:P0AG16"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P0AG16 (evidence: ECO:0000255). Binds 1 Mg(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AG16"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AG16 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AG16.json""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-049_616fa3df574f	UniProtKB:P15254	pathwaymech:enables	RHEA:17130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15254		"[{""reference_id"": ""UniProtKB:P15254"", ""source_assertion"": ""UniProt annotates UniProtKB:P15254 with catalytic activity for the reaction family of RHEA:17130. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P15254"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P15254 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P15254.json""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-050_9d551e79fd50	UniProtKB:P15254	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15254		"[{""reference_id"": ""UniProtKB:P15254"", ""source_assertion"": ""UniProt locates UniProtKB:P15254 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255, ECO:0000269."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P15254"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P15254 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P15254.json""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-051_be29b027431f	UniProtKB:P15640	pathwaymech:enables	RHEA:17454	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15640		"[{""reference_id"": ""UniProtKB:P15640"", ""source_assertion"": ""UniProt annotates UniProtKB:P15640 with catalytic activity for the reaction family of RHEA:17454. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P15640"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P15640 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P15640.json""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-052_f2935d2682f4	UniProtKB:P15640	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15640		"[{""reference_id"": ""UniProtKB:P15640"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P15640 (evidence: ECO:0000269). Binds 1 Mg(2+) or Mn(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P15640"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P15640 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P15640.json""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-053_efc6257f398c	UniProtKB:P15640	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15640		"[{""reference_id"": ""UniProtKB:P15640"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P15640 (evidence: ECO:0000250). Binds 1 Mg(2+) or Mn(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P15640"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P15640 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P15640.json""}]"	""
pathwaymech:MetaCyc_PWY-6122_edge-054_9db27a2ce434	UniProtKB:P33221	pathwaymech:enables	RHEA:24830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33221		"[{""reference_id"": ""UniProtKB:P33221"", ""source_assertion"": ""UniProt annotates UniProtKB:P33221 with catalytic activity for the reaction family of RHEA:24830. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P33221"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P33221 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33221.json""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-001_83078c51afab	gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN	RO:0002233	CHEBI:44841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN RO:0002233 gomodel:CHEBI_44841_H2NEOPTERINALDOL-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/0; endpoint types: /individuals/22/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-002_89c8f63daebf	gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN BFO:0000066 gomodel:reaction_H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/1; endpoint types: /individuals/21/type; /individuals/59/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-003_4070de01e1a7	gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN RO:0002234 gomodel:CHEBI_29888_H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/2; endpoint types: /individuals/21/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-004_1e6e3d743f46	gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN	RO:0002413	gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN RO:0002413 gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/3; endpoint types: /individuals/21/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-005_656474947933	gomodel:GTP-CYCLOHYDRO-I-RXN	RO:0002413	gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:GTP-CYCLOHYDRO-I-RXN RO:0002413 gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/4; endpoint types: /individuals/19/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-006_090babe273ed	gomodel:YeastPathways_PWY-6147/6a6bcaed00000919	pathwaymech:enables	gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN RO:0002333 gomodel:YeastPathways_PWY-6147/6a6bcaed00000919."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/5; endpoint types: /individuals/21/type; /individuals/66/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-007_cbf1b7f434cd	gomodel:GTP-CYCLOHYDRO-I-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:GTP-CYCLOHYDRO-I-RXN BFO:0000066 gomodel:reaction_GTP-CYCLOHYDRO-I-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/6; endpoint types: /individuals/19/type; /individuals/57/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-008_fa97c99cf8e0	gomodel:H2NEOPTERINALDOL-RXN	BFO:0000050	GO:0046656	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2NEOPTERINALDOL-RXN BFO:0000050 gomodel:YeastPathways_PWY-6147/YeastPathways_PWY-6147."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/7; endpoint types: /individuals/20/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-010_85dc26d2ee28	gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN RO:0002234 gomodel:CHEBI_15378_H2PTERIDINEPYROPHOSPHOKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/9; endpoint types: /individuals/22/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-011_623076326ed4	gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN	RO:0002233	CHEBI:58762	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN RO:0002233 gomodel:CHEBI_58762_H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/10; endpoint types: /individuals/18/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-012_fb6f4ed97c50	gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN	BFO:0000050	GO:0046656	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN BFO:0000050 gomodel:YeastPathways_PWY-6147/YeastPathways_PWY-6147."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/11; endpoint types: /individuals/18/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-013_b460220e02b9	gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN	BFO:0000050	GO:0046656	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN BFO:0000050 gomodel:YeastPathways_PWY-6147/YeastPathways_PWY-6147."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/12; endpoint types: /individuals/21/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-014_ebcbd5548f05	gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN	BFO:0000050	GO:0046656	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN BFO:0000050 gomodel:YeastPathways_PWY-6147/YeastPathways_PWY-6147."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/13; endpoint types: /individuals/22/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-015_98257ebdd2a8	gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN	RO:0002234	CHEBI:17001	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN RO:0002234 gomodel:CHEBI_17001_DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/14; endpoint types: /individuals/18/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-016_79e028cc3984	gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN	RO:0002234	CHEBI:73083	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN RO:0002234 gomodel:CHEBI_73083_H2PTERIDINEPYROPHOSPHOKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/15; endpoint types: /individuals/22/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-017_695cb1b5f59e	gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN RO:0002234 gomodel:CHEBI_456215_H2PTERIDINEPYROPHOSPHOKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/16; endpoint types: /individuals/22/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-018_08022e8d5051	gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN	RO:0002233	CHEBI:58462	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN RO:0002233 gomodel:CHEBI_58462_GTP-CYCLOHYDRO-I-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/17; endpoint types: /individuals/21/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-019_6288b4ca11cb	gomodel:H2NEOPTERINALDOL-RXN	RO:0002234	CHEBI:17071	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2NEOPTERINALDOL-RXN RO:0002234 gomodel:CHEBI_17071_H2NEOPTERINALDOL-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/18; endpoint types: /individuals/20/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-020_eee258cb5091	gomodel:H2NEOPTERINALDOL-RXN	RO:0002234	CHEBI:44841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2NEOPTERINALDOL-RXN RO:0002234 gomodel:CHEBI_44841_H2NEOPTERINALDOL-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/19; endpoint types: /individuals/20/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-021_61b0ca0690c0	gomodel:YeastPathways_PWY-6147/6a6bcaed00000922	pathwaymech:enables	gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN RO:0002333 gomodel:YeastPathways_PWY-6147/6a6bcaed00000922."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/20; endpoint types: /individuals/18/type; /individuals/68/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-022_943814c540d5	gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN RO:0002234 gomodel:CHEBI_43474_DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/21; endpoint types: /individuals/18/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-023_46035248c677	SGD:S000003499	pathwaymech:enables	gomodel:GTP-CYCLOHYDRO-I-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:GTP-CYCLOHYDRO-I-RXN RO:0002333 gomodel:YGR267C-MONOMER_GTP-CYCLOHYDRO-I-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/22; endpoint types: /individuals/19/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-024_796e679026a4	gomodel:GTP-CYCLOHYDRO-I-RXN	RO:0002234	CHEBI:15740	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:GTP-CYCLOHYDRO-I-RXN RO:0002234 gomodel:CHEBI_15740_GTP-CYCLOHYDRO-I-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/23; endpoint types: /individuals/19/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-025_d5a5ed1db18c	gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN RO:0002233 gomodel:CHEBI_30616_H2PTERIDINEPYROPHOSPHOKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/24; endpoint types: /individuals/22/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-026_7e128d93ed2d	gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN	RO:0002234	CHEBI:58762	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN RO:0002234 gomodel:CHEBI_58762_H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/25; endpoint types: /individuals/21/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-027_9fe81669aae7	gomodel:H2NEOPTERINALDOL-RXN	RO:0002413	gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2NEOPTERINALDOL-RXN RO:0002413 gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/26; endpoint types: /individuals/20/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-028_eb7f0707b19e	gomodel:GTP-CYCLOHYDRO-I-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:GTP-CYCLOHYDRO-I-RXN RO:0002233 gomodel:CHEBI_15377_GTP-CYCLOHYDRO-I-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/27; endpoint types: /individuals/19/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-029_6c7e780db1ab	gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN RO:0002234 gomodel:CHEBI_15378_H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/28; endpoint types: /individuals/21/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-030_7ac2f8365612	gomodel:GTP-CYCLOHYDRO-I-RXN	BFO:0000050	GO:0046656	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:GTP-CYCLOHYDRO-I-RXN BFO:0000050 gomodel:YeastPathways_PWY-6147/YeastPathways_PWY-6147."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/29; endpoint types: /individuals/19/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-031_6e4bf9e1faeb	SGD:S000005200	pathwaymech:enables	gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN RO:0002333 gomodel:YNL256W-MONOMER_H2PTERIDINEPYROPHOSPHOKIN-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/30; endpoint types: /individuals/22/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-032_f5e3e74f6d39	gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN BFO:0000066 gomodel:reaction_DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/31; endpoint types: /individuals/18/type; /individuals/56/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-033_eb2044bc2030	gomodel:GTP-CYCLOHYDRO-I-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:GTP-CYCLOHYDRO-I-RXN RO:0002234 gomodel:CHEBI_15378_GTP-CYCLOHYDRO-I-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/32; endpoint types: /individuals/19/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-034_4002de220515	gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN RO:0002233 gomodel:CHEBI_15377_H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/33; endpoint types: /individuals/21/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-035_bc892a4b9c2e	gomodel:H2NEOPTERINALDOL-RXN	RO:0002233	CHEBI:17001	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2NEOPTERINALDOL-RXN RO:0002233 gomodel:CHEBI_17001_DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/34; endpoint types: /individuals/20/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-036_ff1447b03d73	gomodel:GTP-CYCLOHYDRO-I-RXN	RO:0002234	CHEBI:58462	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:GTP-CYCLOHYDRO-I-RXN RO:0002234 gomodel:CHEBI_58462_GTP-CYCLOHYDRO-I-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/35; endpoint types: /individuals/19/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-038_b7a57ed5a939	gomodel:GTP-CYCLOHYDRO-I-RXN	RO:0002233	CHEBI:37565	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:GTP-CYCLOHYDRO-I-RXN RO:0002233 gomodel:CHEBI_37565_GTP-CYCLOHYDRO-I-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/37; endpoint types: /individuals/19/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-039_2ac5738bd0b5	gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN RO:0002233 gomodel:CHEBI_15377_DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/38; endpoint types: /individuals/18/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-040_bab91ea4a2d8	gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN	RO:0002413	gomodel:H2NEOPTERINALDOL-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN RO:0002413 gomodel:H2NEOPTERINALDOL-RXN."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/39; endpoint types: /individuals/18/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_edge-041_49ca63e92f66	SGD:S000005200	pathwaymech:enables	gomodel:H2NEOPTERINALDOL-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6147		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6147"", ""source_assertion"": ""The model asserts gomodel:H2NEOPTERINALDOL-RXN RO:0002333 gomodel:YNL256W-MONOMER_H2NEOPTERINALDOL-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-6147.json#/facts/40; endpoint types: /individuals/20/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6147"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json"", ""title"": ""GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_location-6a03828d3d37_272f47dfcc5c	SGD:S000005200	RO:0001025	GO:0031966	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53848	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14576278); ECO:0000269 (PubMed:15169867)	"[{""reference_id"": ""UniProtKB:P53848"", ""source_assertion"": ""UniProtKB:P53848 annotates location Mitochondrion membrane (SL-0171)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2262/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53848"", ""source_assertion"": ""UniProtKB:P53848 has the exact SGD cross-reference SGD:S000005200."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2262/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53848"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53848 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6147_cofactor-56d69a096f5c_bba2ce333231	SGD:S000005200	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53848	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P0AC13)	"[{""reference_id"": ""UniProtKB:P53848"", ""source_assertion"": ""UniProtKB:P53848 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2262/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P53848"", ""source_assertion"": ""UniProtKB:P53848 has the exact SGD cross-reference SGD:S000005200."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2262/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53848"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53848 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:GO_0097288_preq0-edge-001_1137c0a2b1aa	CHEBI:37565	pathwaymech:consumes	RHEA:17474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17473	Coefficient 1 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained.	"[{""reference_id"": ""RHEA:17473"", ""source_assertion"": ""RHEA:17474 substrates side 17473_L has coefficient 1 for Participant_17473_compound_6355; its compound accession is CHEBI:37565."", ""source_locator"": ""http://rdf.rhea-db.org/17474 rh:substrates; http://rdf.rhea-db.org/17473_L rh:contains1 http://rdf.rhea-db.org/Participant_17473_compound_6355; rh:compound http://rdf.rhea-db.org/Compound_6355; rh:accession""}]"	"[{""id"": ""RHEA:17473"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 17473 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-002_8b1123159e8e	CHEBI:15377	pathwaymech:consumes	RHEA:17474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17473	Coefficient 1 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained.	"[{""reference_id"": ""RHEA:17473"", ""source_assertion"": ""RHEA:17474 substrates side 17473_L has coefficient 1 for Participant_17473_compound_1283; its compound accession is CHEBI:15377."", ""source_locator"": ""http://rdf.rhea-db.org/17474 rh:substrates; http://rdf.rhea-db.org/17473_L rh:contains1 http://rdf.rhea-db.org/Participant_17473_compound_1283; rh:compound http://rdf.rhea-db.org/Compound_1283; rh:accession""}]"	"[{""id"": ""RHEA:17473"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 17473 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-003_db0a635f2ecf	RHEA:17474	pathwaymech:produces	CHEBI:58462	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17473	Coefficient 1 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained.	"[{""reference_id"": ""RHEA:17473"", ""source_assertion"": ""RHEA:17474 products side 17473_R has coefficient 1 for Participant_17473_compound_2443; its compound accession is CHEBI:58462."", ""source_locator"": ""http://rdf.rhea-db.org/17474 rh:products; http://rdf.rhea-db.org/17473_R rh:contains1 http://rdf.rhea-db.org/Participant_17473_compound_2443; rh:compound http://rdf.rhea-db.org/Compound_2443; rh:accession""}]"	"[{""id"": ""RHEA:17473"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 17473 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-004_0b0fb8aa1d90	RHEA:17474	pathwaymech:produces	CHEBI:15740	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17473	Coefficient 1 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained.	"[{""reference_id"": ""RHEA:17473"", ""source_assertion"": ""RHEA:17474 products side 17473_R has coefficient 1 for Participant_17473_compound_3001; its compound accession is CHEBI:15740."", ""source_locator"": ""http://rdf.rhea-db.org/17474 rh:products; http://rdf.rhea-db.org/17473_R rh:contains1 http://rdf.rhea-db.org/Participant_17473_compound_3001; rh:compound http://rdf.rhea-db.org/Compound_3001; rh:accession""}]"	"[{""id"": ""RHEA:17473"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 17473 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-005_3738767fb263	RHEA:17474	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17473	Coefficient 1 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained.	"[{""reference_id"": ""RHEA:17473"", ""source_assertion"": ""RHEA:17474 products side 17473_R has coefficient 1 for Participant_17473_compound_3249; its compound accession is CHEBI:15378."", ""source_locator"": ""http://rdf.rhea-db.org/17474 rh:products; http://rdf.rhea-db.org/17473_R rh:contains1 http://rdf.rhea-db.org/Participant_17473_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:17473"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 17473 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-006_1b4037f8a7c8	CHEBI:58462	pathwaymech:consumes	RHEA:27967	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27966	Coefficient 1 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained.	"[{""reference_id"": ""RHEA:27966"", ""source_assertion"": ""RHEA:27967 substrates side 27966_L has coefficient 1 for Participant_27966_compound_2443; its compound accession is CHEBI:58462."", ""source_locator"": ""http://rdf.rhea-db.org/27967 rh:substrates; http://rdf.rhea-db.org/27966_L rh:contains1 http://rdf.rhea-db.org/Participant_27966_compound_2443; rh:compound http://rdf.rhea-db.org/Compound_2443; rh:accession""}]"	"[{""id"": ""RHEA:27966"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27966 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-007_640c06ac0a02	CHEBI:15377	pathwaymech:consumes	RHEA:27967	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27966	Coefficient 1 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained.	"[{""reference_id"": ""RHEA:27966"", ""source_assertion"": ""RHEA:27967 substrates side 27966_L has coefficient 1 for Participant_27966_compound_1283; its compound accession is CHEBI:15377."", ""source_locator"": ""http://rdf.rhea-db.org/27967 rh:substrates; http://rdf.rhea-db.org/27966_L rh:contains1 http://rdf.rhea-db.org/Participant_27966_compound_1283; rh:compound http://rdf.rhea-db.org/Compound_1283; rh:accession""}]"	"[{""id"": ""RHEA:27966"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27966 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-008_ce1b811092a4	RHEA:27967	pathwaymech:produces	CHEBI:61032	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27966	Coefficient 1 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained.	"[{""reference_id"": ""RHEA:27966"", ""source_assertion"": ""RHEA:27967 products side 27966_R has coefficient 1 for Participant_27966_compound_6305; its compound accession is CHEBI:61032."", ""source_locator"": ""http://rdf.rhea-db.org/27967 rh:products; http://rdf.rhea-db.org/27966_R rh:contains1 http://rdf.rhea-db.org/Participant_27966_compound_6305; rh:compound http://rdf.rhea-db.org/Compound_6305; rh:accession""}]"	"[{""id"": ""RHEA:27966"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27966 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-009_0a7df29d5024	RHEA:27967	pathwaymech:produces	CHEBI:18036	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27966	Coefficient 1 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained.	"[{""reference_id"": ""RHEA:27966"", ""source_assertion"": ""RHEA:27967 products side 27966_R has coefficient 1 for Participant_27966_compound_5288; its compound accession is CHEBI:18036."", ""source_locator"": ""http://rdf.rhea-db.org/27967 rh:products; http://rdf.rhea-db.org/27966_R rh:contains1 http://rdf.rhea-db.org/Participant_27966_compound_5288; rh:compound http://rdf.rhea-db.org/Compound_5288; rh:accession""}]"	"[{""id"": ""RHEA:27966"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27966 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-010_06c68a75186d	RHEA:27967	pathwaymech:produces	CHEBI:15343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27966	Coefficient 1 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained.	"[{""reference_id"": ""RHEA:27966"", ""source_assertion"": ""RHEA:27967 products side 27966_R has coefficient 1 for Participant_27966_compound_3952; its compound accession is CHEBI:15343."", ""source_locator"": ""http://rdf.rhea-db.org/27967 rh:products; http://rdf.rhea-db.org/27966_R rh:contains1 http://rdf.rhea-db.org/Participant_27966_compound_3952; rh:compound http://rdf.rhea-db.org/Compound_3952; rh:accession""}]"	"[{""id"": ""RHEA:27966"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27966 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-011_a8daf2c37a3e	RHEA:27967	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27966	Coefficient 2 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained.	"[{""reference_id"": ""RHEA:27966"", ""source_assertion"": ""RHEA:27967 products side 27966_R has coefficient 2 for Participant_27966_compound_3249; its compound accession is CHEBI:15378."", ""source_locator"": ""http://rdf.rhea-db.org/27967 rh:products; http://rdf.rhea-db.org/27966_R rh:contains2 http://rdf.rhea-db.org/Participant_27966_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:27966"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27966 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-012_6327543755e2	CHEBI:61032	pathwaymech:consumes	RHEA:27975	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27974	Coefficient 1 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained.	"[{""reference_id"": ""RHEA:27974"", ""source_assertion"": ""RHEA:27975 substrates side 27974_L has coefficient 1 for Participant_27974_compound_6305; its compound accession is CHEBI:61032."", ""source_locator"": ""http://rdf.rhea-db.org/27975 rh:substrates; http://rdf.rhea-db.org/27974_L rh:contains1 http://rdf.rhea-db.org/Participant_27974_compound_6305; rh:compound http://rdf.rhea-db.org/Compound_6305; rh:accession""}]"	"[{""id"": ""RHEA:27974"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27974 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-013_e24ac9c7aba4	CHEBI:15378	pathwaymech:consumes	RHEA:27975	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27974	Coefficient 1 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained.	"[{""reference_id"": ""RHEA:27974"", ""source_assertion"": ""RHEA:27975 substrates side 27974_L has coefficient 1 for Participant_27974_compound_3249; its compound accession is CHEBI:15378."", ""source_locator"": ""http://rdf.rhea-db.org/27975 rh:substrates; http://rdf.rhea-db.org/27974_L rh:contains1 http://rdf.rhea-db.org/Participant_27974_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:27974"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27974 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-014_789e4df41e3a	RHEA:27975	pathwaymech:produces	CHEBI:61036	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27974	Coefficient 1 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained.	"[{""reference_id"": ""RHEA:27974"", ""source_assertion"": ""RHEA:27975 products side 27974_R has coefficient 1 for Participant_27974_compound_6307; its compound accession is CHEBI:61036."", ""source_locator"": ""http://rdf.rhea-db.org/27975 rh:products; http://rdf.rhea-db.org/27974_R rh:contains1 http://rdf.rhea-db.org/Participant_27974_compound_6307; rh:compound http://rdf.rhea-db.org/Compound_6307; rh:accession""}]"	"[{""id"": ""RHEA:27974"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27974 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-015_6ed27f12c8c1	RHEA:27975	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27974	Coefficient 1 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained.	"[{""reference_id"": ""RHEA:27974"", ""source_assertion"": ""RHEA:27975 products side 27974_R has coefficient 1 for Participant_27974_compound_1012; its compound accession is CHEBI:28938."", ""source_locator"": ""http://rdf.rhea-db.org/27975 rh:products; http://rdf.rhea-db.org/27974_R rh:contains1 http://rdf.rhea-db.org/Participant_27974_compound_1012; rh:compound http://rdf.rhea-db.org/Compound_1012; rh:accession""}]"	"[{""id"": ""RHEA:27974"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27974 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-016_77267bc27241	CHEBI:61036	pathwaymech:consumes	RHEA:27983	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27982	Coefficient 1 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained. The current two-ATP net equation supersedes the obsolete one-ATP/ADP equation in MetaCyc 22.5 and PathBank; no component reactions are double counted.	"[{""reference_id"": ""RHEA:27982"", ""source_assertion"": ""RHEA:27983 substrates side 27982_L has coefficient 1 for Participant_27982_compound_6307; its compound accession is CHEBI:61036."", ""source_locator"": ""http://rdf.rhea-db.org/27983 rh:substrates; http://rdf.rhea-db.org/27982_L rh:contains1 http://rdf.rhea-db.org/Participant_27982_compound_6307; rh:compound http://rdf.rhea-db.org/Compound_6307; rh:accession""}]"	"[{""id"": ""RHEA:27982"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27982 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-017_b8c460150edd	CHEBI:28938	pathwaymech:consumes	RHEA:27983	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27982	Coefficient 1 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained. The current two-ATP net equation supersedes the obsolete one-ATP/ADP equation in MetaCyc 22.5 and PathBank; no component reactions are double counted.	"[{""reference_id"": ""RHEA:27982"", ""source_assertion"": ""RHEA:27983 substrates side 27982_L has coefficient 1 for Participant_27982_compound_1012; its compound accession is CHEBI:28938."", ""source_locator"": ""http://rdf.rhea-db.org/27983 rh:substrates; http://rdf.rhea-db.org/27982_L rh:contains1 http://rdf.rhea-db.org/Participant_27982_compound_1012; rh:compound http://rdf.rhea-db.org/Compound_1012; rh:accession""}]"	"[{""id"": ""RHEA:27982"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27982 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-018_2615d13b1518	CHEBI:30616	pathwaymech:consumes	RHEA:27983	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27982	Coefficient 2 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained. The current two-ATP net equation supersedes the obsolete one-ATP/ADP equation in MetaCyc 22.5 and PathBank; no component reactions are double counted.	"[{""reference_id"": ""RHEA:27982"", ""source_assertion"": ""RHEA:27983 substrates side 27982_L has coefficient 2 for Participant_27982_compound_6372; its compound accession is CHEBI:30616."", ""source_locator"": ""http://rdf.rhea-db.org/27983 rh:substrates; http://rdf.rhea-db.org/27982_L rh:contains2 http://rdf.rhea-db.org/Participant_27982_compound_6372; rh:compound http://rdf.rhea-db.org/Compound_6372; rh:accession""}]"	"[{""id"": ""RHEA:27982"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27982 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-019_ee21795ca1da	RHEA:27983	pathwaymech:produces	CHEBI:45075	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27982	Coefficient 1 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained. The current two-ATP net equation supersedes the obsolete one-ATP/ADP equation in MetaCyc 22.5 and PathBank; no component reactions are double counted.	"[{""reference_id"": ""RHEA:27982"", ""source_assertion"": ""RHEA:27983 products side 27982_R has coefficient 1 for Participant_27982_compound_5843; its compound accession is CHEBI:45075."", ""source_locator"": ""http://rdf.rhea-db.org/27983 rh:products; http://rdf.rhea-db.org/27982_R rh:contains1 http://rdf.rhea-db.org/Participant_27982_compound_5843; rh:compound http://rdf.rhea-db.org/Compound_5843; rh:accession""}]"	"[{""id"": ""RHEA:27982"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27982 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-020_91d695c2d4e7	RHEA:27983	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27982	Coefficient 2 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained. The current two-ATP net equation supersedes the obsolete one-ATP/ADP equation in MetaCyc 22.5 and PathBank; no component reactions are double counted.	"[{""reference_id"": ""RHEA:27982"", ""source_assertion"": ""RHEA:27983 products side 27982_R has coefficient 2 for Participant_27982_compound_2590; its compound accession is CHEBI:456215."", ""source_locator"": ""http://rdf.rhea-db.org/27983 rh:products; http://rdf.rhea-db.org/27982_R rh:contains2 http://rdf.rhea-db.org/Participant_27982_compound_2590; rh:compound http://rdf.rhea-db.org/Compound_2590; rh:accession""}]"	"[{""id"": ""RHEA:27982"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27982 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-021_d52a70737a91	RHEA:27983	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27982	Coefficient 2 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained. The current two-ATP net equation supersedes the obsolete one-ATP/ADP equation in MetaCyc 22.5 and PathBank; no component reactions are double counted.	"[{""reference_id"": ""RHEA:27982"", ""source_assertion"": ""RHEA:27983 products side 27982_R has coefficient 2 for Participant_27982_compound_2106; its compound accession is CHEBI:33019."", ""source_locator"": ""http://rdf.rhea-db.org/27983 rh:products; http://rdf.rhea-db.org/27982_R rh:contains2 http://rdf.rhea-db.org/Participant_27982_compound_2106; rh:compound http://rdf.rhea-db.org/Compound_2106; rh:accession""}]"	"[{""id"": ""RHEA:27982"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27982 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-022_7510e524b74b	RHEA:27983	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27982	Coefficient 2 in the selected Rhea 142 biosynthetic direction; the exact charge form is retained. The current two-ATP net equation supersedes the obsolete one-ATP/ADP equation in MetaCyc 22.5 and PathBank; no component reactions are double counted.	"[{""reference_id"": ""RHEA:27982"", ""source_assertion"": ""RHEA:27983 products side 27982_R has coefficient 2 for Participant_27982_compound_3249; its compound accession is CHEBI:15378."", ""source_locator"": ""http://rdf.rhea-db.org/27983 rh:products; http://rdf.rhea-db.org/27982_R rh:contains2 http://rdf.rhea-db.org/Participant_27982_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:27982"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27982 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-023_7b7018279b4f	UniProtKB:P0A6T5	BFO:0000050	MetaCyc:FOLE-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:FOLE-CPLX|UniProtKB:P0A6T5	FolE is a subunit of the independently identified native homodecamer; ten polypeptides form the assembly.	"[{""reference_id"": ""MetaCyc:FOLE-CPLX"", ""source_assertion"": ""FOLE-CPLX contains ten copies of GTP-CYCLOHYDRO-I-MONOMER."", ""source_locator"": ""Protein[@frameid=\""FOLE-CPLX\""]/component/Protein; component/coefficient""}, {""reference_id"": ""UniProtKB:P0A6T5"", ""source_assertion"": ""The reviewed entry explicitly cross-references MetaCyc:GTP-CYCLOHYDRO-I-MONOMER and annotates a toroid-shaped homodecamer, with ECO:0000269 citations."", ""source_locator"": ""uniProtKBCrossReferences[database=\""BioCyc\""]; comments[3]""}]"	"[{""id"": ""MetaCyc:FOLE-CPLX"", ""source_sha256"": ""02a1387ca3463fcdc819710574fdcfaba6688579873fd069a9c172e1333320e8"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers complete XML response body"", ""title"": ""MetaCyc FOLE-CPLX original native object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:FOLE-CPLX""}, {""id"": ""UniProtKB:P0A6T5"", ""source_sha256"": ""c81d6948a4c2f1043c216c6ff6de92554b2910ffd116c82ba6a1b9eec7ee7918"", ""source_version"": ""UniProt 2026_03; released 2026-09-02; retrieved 2026-10-11; digest covers complete entry JSON body"", ""title"": ""GTP cyclohydrolase 1 — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6T5.json""}]"	""
pathwaymech:GO_0097288_preq0-edge-024_df8983e805dd	UniProtKB:P65870	BFO:0000050	MetaCyc:CPLX0-8123	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8123|MetaCyc:G7431-MONOMER|UniProtKB:P65870	The selected native QueD assembly contains six subunits and corresponds to the crystallographic hexamer. Reviewed UniProt also reports trimers and dodecamers in solution; this edge does not assert a unique assembly under all conditions.	"[{""reference_id"": ""MetaCyc:CPLX0-8123"", ""source_assertion"": ""CPLX0-8123 contains six copies of G7431-MONOMER and describes a hexamer of interacting trimers."", ""source_locator"": ""Protein[@frameid=\""CPLX0-8123\""]/component; comment""}, {""reference_id"": ""MetaCyc:G7431-MONOMER"", ""source_assertion"": ""G7431-MONOMER has an explicit UNIPROT unification cross-reference to P65870."", ""source_locator"": ""Protein[@frameid=\""G7431-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:P65870"", ""source_assertion"": ""The reviewed entry reports homotrimers and homododecamers in solution (PMID:24816091), and six active sites at trimer interfaces in the crystal homohexamer (PMID:24990950); both are ECO:0000269 statements."", ""source_locator"": ""comments[7]; comments[8]""}]"	"[{""id"": ""MetaCyc:CPLX0-8123"", ""source_sha256"": ""1331fe09318ec0cb5c1d7ec77dc9b00a635e09b621db870ae9925860bd2d490d"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers complete XML response body"", ""title"": ""MetaCyc CPLX0-8123 original native object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8123""}, {""id"": ""MetaCyc:G7431-MONOMER"", ""source_sha256"": ""5bffad8d7e788211298f4dacc95d4a281528184cdeeea03fe3735a31d539a5f4"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers complete XML response body"", ""title"": ""MetaCyc G7431-MONOMER original native object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G7431-MONOMER""}, {""id"": ""UniProtKB:P65870"", ""source_sha256"": ""82ac75c023f2037278a76412a91af77d18a1a2d6abe621da46ec66b6d285dd97"", ""source_version"": ""UniProt 2026_03; released 2026-09-02; retrieved 2026-10-11; digest covers complete entry JSON body"", ""title"": ""6-carboxy-5,6,7,8-tetrahydropterin synthase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P65870.json""}]"	""
pathwaymech:GO_0097288_preq0-edge-025_c9b66f97d6b4	MetaCyc:FOLE-CPLX	pathwaymech:catalyzes	RHEA:17474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:FOLE-CPLX|PMID:19231875|UniProtKB:P0A6T5	The FolE assembly provides the first transformation shared with folate and other pterin pathways.	"[{""reference_id"": ""MetaCyc:FOLE-CPLX"", ""source_assertion"": ""FOLE-CPLX catalyzes GTP-CYCLOHYDRO-I-RXN through GTP-CYCLOHYDRO-I-ENZRXN."", ""source_locator"": ""Protein/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:P0A6T5"", ""source_assertion"": ""The reviewed catalytic activity names RHEA:17473, GTP hydrolysis to dihydroneopterin triphosphate, formate and H+."", ""source_locator"": ""comments[0]/reaction""}, {""reference_id"": ""PMID:19231875"", ""source_assertion"": ""Recombinant E. coli FolE generated dihydroneopterin triphosphate quantitatively from GTP for the QueD assays."", ""source_locator"": ""PMC3227869 BioC passage[5]; Figure 2A and caption passage[17]""}]"	"[{""id"": ""MetaCyc:FOLE-CPLX"", ""source_sha256"": ""02a1387ca3463fcdc819710574fdcfaba6688579873fd069a9c172e1333320e8"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers complete XML response body"", ""title"": ""MetaCyc FOLE-CPLX original native object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:FOLE-CPLX""}, {""id"": ""PMID:19231875"", ""source_sha256"": ""663cf3fe09cb4c85cedefde4f2dd34daacacae1fe4f0e8dff5a240a2d7a9c1b1"", ""source_version"": ""Primary full manuscript, NCBI BioC; retrieved 2026-10-11; digest covers complete XML body"", ""title"": ""Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase."", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC3227869/unicode""}, {""id"": ""UniProtKB:P0A6T5"", ""source_sha256"": ""c81d6948a4c2f1043c216c6ff6de92554b2910ffd116c82ba6a1b9eec7ee7918"", ""source_version"": ""UniProt 2026_03; released 2026-09-02; retrieved 2026-10-11; digest covers complete entry JSON body"", ""title"": ""GTP cyclohydrolase 1 — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6T5.json""}]"	""
pathwaymech:GO_0097288_preq0-edge-026_5b2a6c598d06	MetaCyc:CPLX0-8123	pathwaymech:catalyzes	RHEA:27967	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8123|PMID:19231875|UniProtKB:P65870	QueD forms carboxytetrahydropterin, not the mammalian pyruvoyltetrahydropterin product. The native crystallographic assembly is retained without excluding other solution assemblies.	"[{""reference_id"": ""MetaCyc:CPLX0-8123"", ""source_assertion"": ""CPLX0-8123 catalyzes RXN0-5507 through ENZRXN0-6612."", ""source_locator"": ""Protein/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:P65870"", ""source_assertion"": ""The RHEA:27966 catalytic activity has ECO:0000269 support from PMID:19231875 and PMID:24990950; physiological direction RHEA:27967 is ECO:0000305."", ""source_locator"": ""comments[1]/reaction; comments[1]/physiologicalReactions""}, {""reference_id"": ""PMID:19231875"", ""source_assertion"": ""E. coli QueD forms CPH4 from H2NTP; isotope-resolved mass spectra, fragmentation and co-elution with chemically reduced carboxypterin establish product identity."", ""source_locator"": ""PMC3227869 BioC passages[5-8]; Figure 2D""}]"	"[{""id"": ""MetaCyc:CPLX0-8123"", ""source_sha256"": ""1331fe09318ec0cb5c1d7ec77dc9b00a635e09b621db870ae9925860bd2d490d"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers complete XML response body"", ""title"": ""MetaCyc CPLX0-8123 original native object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8123""}, {""id"": ""PMID:19231875"", ""source_sha256"": ""663cf3fe09cb4c85cedefde4f2dd34daacacae1fe4f0e8dff5a240a2d7a9c1b1"", ""source_version"": ""Primary full manuscript, NCBI BioC; retrieved 2026-10-11; digest covers complete XML body"", ""title"": ""Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase."", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC3227869/unicode""}, {""id"": ""UniProtKB:P65870"", ""source_sha256"": ""82ac75c023f2037278a76412a91af77d18a1a2d6abe621da46ec66b6d285dd97"", ""source_version"": ""UniProt 2026_03; released 2026-09-02; retrieved 2026-10-11; digest covers complete entry JSON body"", ""title"": ""6-carboxy-5,6,7,8-tetrahydropterin synthase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P65870.json""}]"	""
pathwaymech:GO_0097288_preq0-edge-027_963f5165f6f6	UniProtKB:P64554	pathwaymech:enables	RHEA:27975	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19354300|PMID:23194065|UniProtKB:P64554	E. coli QueE is assigned this catalytic role by reviewed HAMAP inference, not by transferring a purified Bacillus experiment to E. coli. UniProt infers a homodimer; no monomer sufficiency is asserted. The net reaction does not consume SAM, which is regenerated in the mechanistically characterized Bacillus enzyme.	"[{""reference_id"": ""UniProtKB:P64554"", ""source_assertion"": ""The reviewed QueE entry assigns RHEA:27974 and a homodimer with ECO:0000255 HAMAP-Rule MF_00917 evidence."", ""source_locator"": ""comments[1]/reaction; comments[6]""}, {""reference_id"": ""PMID:19354300"", ""source_assertion"": ""B. subtilis QueE converted CPH4 to CDG in the mixed-species reconstruction; the cloned and assayed QueE was Bacillus, not the E. coli expression host."", ""source_locator"": ""PMC2693876 BioC passages[9-14], [34-36]; Figure 2""}, {""reference_id"": ""PMID:23194065"", ""source_assertion"": ""For B. subtilis QueE, product formed in 15-fold excess over supplied SAM, demonstrating regeneration of the cofactor rather than stoichiometric consumption."", ""source_locator"": ""PMC4022186 BioC passage[58]; Figure 3e""}]"	"[{""id"": ""PMID:19354300"", ""source_sha256"": ""96518ba9383486651b318b6e4097995880dbee1ec47b68d2c40e7ec69367e9fd"", ""source_version"": ""Primary full manuscript, NCBI BioC; retrieved 2026-10-11; digest covers complete XML body"", ""title"": ""The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps."", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC2693876/unicode""}, {""id"": ""PMID:23194065"", ""source_sha256"": ""be5556c14ac6a44d5d16707cd10986e87fdf2310207ca4c91cf5aba6b6d223e9"", ""source_version"": ""Primary full manuscript, NCBI BioC; retrieved 2026-10-11; digest covers complete XML body"", ""title"": ""Spectroscopic, steady-state kinetic, and mechanistic characterization of the radical SAM enzyme QueE, which catalyzes a complex cyclization reaction in the biosynthesis of 7-deazapurines."", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC4022186/unicode""}, {""id"": ""UniProtKB:P64554"", ""source_sha256"": ""923379bf5a0a87d75e5e6be7bcf1a56996706bc8f2bad136a6d00ea77afcc40d"", ""source_version"": ""UniProt 2026_03; released 2026-09-02; retrieved 2026-10-11; digest covers complete entry JSON body"", ""title"": ""7-carboxy-7-deazaguanine synthase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P64554.json""}]"	""
pathwaymech:GO_0097288_preq0-edge-028_0a5507299338	UniProtKB:P77756	pathwaymech:enables	RHEA:27983	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:16199558|PMID:26228534|UniProtKB:P77756	The E. coli QueC gene product is assigned the current two-ATP nitrile-forming net activity by reviewed HAMAP inference. Genetic complementation supports its upstream role; it does not independently measure the exact stoichiometry or establish monomer sufficiency. The two-adenylation mechanism was experimentally resolved for Streptomyces ToyM.	"[{""reference_id"": ""UniProtKB:P77756"", ""source_assertion"": ""The current reviewed net RHEA:27982 reaction and physiological RHEA:27983 direction consume two ATP and yield two AMP plus two diphosphate, assigned with ECO:0000255 HAMAP-Rule MF_01633."", ""source_locator"": ""comments[1]/reaction; comments[1]/physiologicalReactions""}, {""reference_id"": ""PMID:16199558"", ""source_assertion"": ""Plasmid-borne queC restored Q modification in E. coli B105; mutant analyses place QueC before preQ0, providing genetic evidence rather than a purified E. coli enzyme assay."", ""source_locator"": ""Europe PMC resultList/result[0]/abstractText""}, {""reference_id"": ""PMID:26228534"", ""source_assertion"": ""Streptomyces rimosus ToyM activates CDG and the amide intermediate through two ATP-dependent half-reactions; AMP and pyrophosphate are produced with both substrates."", ""source_locator"": ""PMC4767005 BioC passages[3], [5-9]; Figures 3-5""}]"	"[{""id"": ""PMID:16199558"", ""source_sha256"": ""eb3c33d8e5cace384e83ca5723f231d8802b60bc9abfcbb82cc26552a0bc2c26"", ""source_version"": ""Europe PMC indexed primary abstract and metadata only; retrieved 2026-10-11; digest covers complete JSON response"", ""title"": ""Genetic analysis identifies a function for the queC (ybaX) gene product at an initial step in the queuosine biosynthetic pathway in Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16199558%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""PMID:26228534"", ""source_sha256"": ""139b2847d21fd6929d4b5ed0db69ed2a8204c899c6a4e6ac54c0f1791d6995f2"", ""source_version"": ""Primary full manuscript, NCBI BioC; retrieved 2026-10-11; digest covers complete XML body"", ""title"": ""A Single Enzyme Transforms a Carboxylic Acid into a Nitrile through an Amide Intermediate."", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC4767005/unicode""}, {""id"": ""UniProtKB:P77756"", ""source_sha256"": ""fced63b09d5a921edf102d8d98ade7f46e962b5bf3299fdd29935e3161653b02"", ""source_version"": ""UniProt 2026_03; released 2026-09-02; retrieved 2026-10-11; digest covers complete entry JSON body"", ""title"": ""7-cyano-7-deazaguanine synthase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77756.json""}]"	""
pathwaymech:GO_0097288_preq0-edge-029_c5da0ae3bc44	UniProtKB:P0A6T5	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:FOLE-CPLX|UniProtKB:P0A6T5	The FolE protein binds catalytically active zinc; binding-site annotation is not evidence for additional free divalent-metal cofactors.	"[{""reference_id"": ""UniProtKB:P0A6T5"", ""source_assertion"": ""The entry annotates zinc-binding sites at residues 111, 114 and 182 with explicit ChEBI:29105 ligand cross-references."", ""source_locator"": ""features[2]; features[3]; features[4]""}, {""reference_id"": ""MetaCyc:FOLE-CPLX"", ""source_assertion"": ""The native enzyme comment identifies a catalytically active zinc ion; cited residue numbering differs by one from the current UniProt sequence."", ""source_locator"": ""Protein[@frameid=\""FOLE-CPLX\""]/comment, paragraph on catalytic zinc""}]"	"[{""id"": ""MetaCyc:FOLE-CPLX"", ""source_sha256"": ""02a1387ca3463fcdc819710574fdcfaba6688579873fd069a9c172e1333320e8"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers complete XML response body"", ""title"": ""MetaCyc FOLE-CPLX original native object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:FOLE-CPLX""}, {""id"": ""UniProtKB:P0A6T5"", ""source_sha256"": ""c81d6948a4c2f1043c216c6ff6de92554b2910ffd116c82ba6a1b9eec7ee7918"", ""source_version"": ""UniProt 2026_03; released 2026-09-02; retrieved 2026-10-11; digest covers complete entry JSON body"", ""title"": ""GTP cyclohydrolase 1 — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6T5.json""}]"	""
pathwaymech:GO_0097288_preq0-edge-030_6dc17b37a0dd	UniProtKB:P65870	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19231875|UniProtKB:P65870	QueD binds one zinc ion per subunit; the directly measured stoichiometry is approximately one equivalent, rather than proof of one invariant oligomeric state.	"[{""reference_id"": ""UniProtKB:P65870"", ""source_assertion"": ""QueD binds one zinc per subunit, with ECO:0000269 support from PMID:19231875, PMID:24816091 and PMID:24990950."", ""source_locator"": ""comments[4]/cofactors; comments[4]/note""}, {""quote"": ""revealed the presence of 1.1 equivalents of Zn per monomer."", ""reference_id"": ""PMID:19231875"", ""source_locator"": ""PMC3227869 BioC passage[9]""}]"	"[{""id"": ""PMID:19231875"", ""source_sha256"": ""663cf3fe09cb4c85cedefde4f2dd34daacacae1fe4f0e8dff5a240a2d7a9c1b1"", ""source_version"": ""Primary full manuscript, NCBI BioC; retrieved 2026-10-11; digest covers complete XML body"", ""title"": ""Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase."", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC3227869/unicode""}, {""id"": ""UniProtKB:P65870"", ""source_sha256"": ""82ac75c023f2037278a76412a91af77d18a1a2d6abe621da46ec66b6d285dd97"", ""source_version"": ""UniProt 2026_03; released 2026-09-02; retrieved 2026-10-11; digest covers complete entry JSON body"", ""title"": ""6-carboxy-5,6,7,8-tetrahydropterin synthase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P65870.json""}]"	""
pathwaymech:GO_0097288_preq0-edge-031_70eea4d9aff2	UniProtKB:P64554	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:23194065|UniProtKB:P64554	The E. coli QueE cofactor assignment is explicitly automatic HAMAP inference; direct mechanistic cofactor measurements were made on B. subtilis QueE.	"[{""reference_id"": ""UniProtKB:P64554"", ""source_assertion"": ""QueE is annotated with one [4Fe-4S] cluster coordinated by three cysteines and exchangeable SAM; ECO:0000255 HAMAP-Rule MF_00917. "", ""source_locator"": ""comments[2]/cofactors; comments[2]/note""}, {""reference_id"": ""PMID:23194065"", ""source_assertion"": ""B. subtilis QueE is a homodimer with a [4Fe-4S] cluster per monomer, magnesium dependence and a SAM cofactor regenerated through multiple turnovers."", ""source_locator"": ""PMC4022186 BioC passage[1]; passages[47], [58], [68]""}]"	"[{""id"": ""PMID:23194065"", ""source_sha256"": ""be5556c14ac6a44d5d16707cd10986e87fdf2310207ca4c91cf5aba6b6d223e9"", ""source_version"": ""Primary full manuscript, NCBI BioC; retrieved 2026-10-11; digest covers complete XML body"", ""title"": ""Spectroscopic, steady-state kinetic, and mechanistic characterization of the radical SAM enzyme QueE, which catalyzes a complex cyclization reaction in the biosynthesis of 7-deazapurines."", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC4022186/unicode""}, {""id"": ""UniProtKB:P64554"", ""source_sha256"": ""923379bf5a0a87d75e5e6be7bcf1a56996706bc8f2bad136a6d00ea77afcc40d"", ""source_version"": ""UniProt 2026_03; released 2026-09-02; retrieved 2026-10-11; digest covers complete entry JSON body"", ""title"": ""7-carboxy-7-deazaguanine synthase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P64554.json""}]"	""
pathwaymech:GO_0097288_preq0-edge-032_24afad0d7902	UniProtKB:P64554	pathwaymech:has_cofactor	CHEBI:59789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:23194065|UniProtKB:P64554	The E. coli QueE cofactor assignment is explicitly automatic HAMAP inference; direct mechanistic cofactor measurements were made on B. subtilis QueE. SAM is catalytic and regenerated in that experiment, so it is not a net substrate or product.	"[{""reference_id"": ""UniProtKB:P64554"", ""source_assertion"": ""QueE is annotated with one S-adenosyl-L-methionine per subunit; ECO:0000255 HAMAP-Rule MF_00917. "", ""source_locator"": ""comments[3]/cofactors; comments[3]/note""}, {""reference_id"": ""PMID:23194065"", ""source_assertion"": ""B. subtilis QueE is a homodimer with a [4Fe-4S] cluster per monomer, magnesium dependence and a SAM cofactor regenerated through multiple turnovers."", ""source_locator"": ""PMC4022186 BioC passage[1]; passages[47], [58], [68]""}]"	"[{""id"": ""PMID:23194065"", ""source_sha256"": ""be5556c14ac6a44d5d16707cd10986e87fdf2310207ca4c91cf5aba6b6d223e9"", ""source_version"": ""Primary full manuscript, NCBI BioC; retrieved 2026-10-11; digest covers complete XML body"", ""title"": ""Spectroscopic, steady-state kinetic, and mechanistic characterization of the radical SAM enzyme QueE, which catalyzes a complex cyclization reaction in the biosynthesis of 7-deazapurines."", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC4022186/unicode""}, {""id"": ""UniProtKB:P64554"", ""source_sha256"": ""923379bf5a0a87d75e5e6be7bcf1a56996706bc8f2bad136a6d00ea77afcc40d"", ""source_version"": ""UniProt 2026_03; released 2026-09-02; retrieved 2026-10-11; digest covers complete entry JSON body"", ""title"": ""7-carboxy-7-deazaguanine synthase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P64554.json""}]"	""
pathwaymech:GO_0097288_preq0-edge-033_3577266686e5	UniProtKB:P64554	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:23194065|UniProtKB:P64554	The E. coli QueE cofactor assignment is explicitly automatic HAMAP inference; direct mechanistic cofactor measurements were made on B. subtilis QueE.	"[{""reference_id"": ""UniProtKB:P64554"", ""source_assertion"": ""QueE is annotated with Mg(2+) as a cofactor; ECO:0000255 HAMAP-Rule MF_00917. "", ""source_locator"": ""comments[4]/cofactors""}, {""reference_id"": ""PMID:23194065"", ""source_assertion"": ""B. subtilis QueE is a homodimer with a [4Fe-4S] cluster per monomer, magnesium dependence and a SAM cofactor regenerated through multiple turnovers."", ""source_locator"": ""PMC4022186 BioC passage[1]; passages[47], [58], [68]""}]"	"[{""id"": ""PMID:23194065"", ""source_sha256"": ""be5556c14ac6a44d5d16707cd10986e87fdf2310207ca4c91cf5aba6b6d223e9"", ""source_version"": ""Primary full manuscript, NCBI BioC; retrieved 2026-10-11; digest covers complete XML body"", ""title"": ""Spectroscopic, steady-state kinetic, and mechanistic characterization of the radical SAM enzyme QueE, which catalyzes a complex cyclization reaction in the biosynthesis of 7-deazapurines."", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC4022186/unicode""}, {""id"": ""UniProtKB:P64554"", ""source_sha256"": ""923379bf5a0a87d75e5e6be7bcf1a56996706bc8f2bad136a6d00ea77afcc40d"", ""source_version"": ""UniProt 2026_03; released 2026-09-02; retrieved 2026-10-11; digest covers complete entry JSON body"", ""title"": ""7-carboxy-7-deazaguanine synthase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P64554.json""}]"	""
pathwaymech:GO_0097288_preq0-edge-034_9d9bb5af584e	UniProtKB:P77756	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19354300|UniProtKB:P77756	QueC zinc binding is a reviewed HAMAP inference for E. coli; the inspected primary zinc measurements concern B. subtilis QueC and S. rimosus ToyM.	"[{""reference_id"": ""UniProtKB:P77756"", ""source_assertion"": ""The current entry assigns one zinc per subunit with ECO:0000255 HAMAP-Rule MF_01633."", ""source_locator"": ""comments[6]/cofactors; comments[6]/note""}, {""reference_id"": ""PMID:19354300"", ""source_assertion"": ""ICP-OES measured 0.88 zinc equivalents per monomer for B. subtilis QueC and 0.80 for S. rimosus ToyM."", ""source_locator"": ""PMC2693876 BioC passage[38]""}]"	"[{""id"": ""PMID:19354300"", ""source_sha256"": ""96518ba9383486651b318b6e4097995880dbee1ec47b68d2c40e7ec69367e9fd"", ""source_version"": ""Primary full manuscript, NCBI BioC; retrieved 2026-10-11; digest covers complete XML body"", ""title"": ""The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps."", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC2693876/unicode""}, {""id"": ""UniProtKB:P77756"", ""source_sha256"": ""fced63b09d5a921edf102d8d98ade7f46e962b5bf3299fdd29935e3161653b02"", ""source_version"": ""UniProt 2026_03; released 2026-09-02; retrieved 2026-10-11; digest covers complete entry JSON body"", ""title"": ""7-cyano-7-deazaguanine synthase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77756.json""}]"	""
pathwaymech:GO_0097288_preq0-edge-035_725902e98926	RHEA:17474	BFO:0000050	GO:0097288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0097288|MetaCyc:GTP-CYCLOHYDRO-I-RXN|MetaCyc:PWY-6703|RHEA:17473	This is one complete native transformation in the exact PreQ0-forming process.	"[{""reference_id"": ""MetaCyc:PWY-6703"", ""source_assertion"": ""PWY-6703 explicitly lists GTP-CYCLOHYDRO-I-RXN among its four reaction members."", ""source_locator"": ""Pathway[@frameid=\""PWY-6703\""]/reaction-list""}, {""reference_id"": ""MetaCyc:GTP-CYCLOHYDRO-I-RXN"", ""source_assertion"": ""The native reaction explicitly cross-references Rhea 17473; its source direction is LEFT-TO-RIGHT."", ""source_locator"": ""Reaction[@frameid=\""GTP-CYCLOHYDRO-I-RXN\""]/dblink[dblink-db=\""RHEA\""]; reaction-direction""}, {""reference_id"": ""RHEA:17473"", ""source_assertion"": ""Master RHEA:17473 declares RHEA:17474 as a directional reaction; the selected full RDF equation is the source for its chemistry."", ""source_locator"": ""http://rdf.rhea-db.org/17473 rh:directionalReaction; http://rdf.rhea-db.org/17474 rh:substrates; rh:products""}, {""reference_id"": ""GO:0097288"", ""source_assertion"": ""GO:0097288 denotes reactions and pathways forming 7-cyano-7-deazaguanine (preQ0), matching the endpoint of the full four-step native route."", ""source_locator"": ""results[0]/definition/text""}]"	"[{""id"": ""GO:0097288"", ""source_sha256"": ""dd854ba91ee0b6c5333f1b6308be951f93f88ce83b1de7d8cc343cde9f3baa4e"", ""source_version"": ""QuickGO response retrieved 2026-10-11; digest covers complete JSON body"", ""title"": ""Gene Ontology exact PreQ0 biosynthetic process definition"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:0097288""}, {""id"": ""MetaCyc:GTP-CYCLOHYDRO-I-RXN"", ""source_sha256"": ""d845a7ac9a12492f42c17057a4344c552edfb3bf9ad3ab76cf60871ce61962b6"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers complete XML response body"", ""title"": ""MetaCyc GTP-CYCLOHYDRO-I-RXN original native object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GTP-CYCLOHYDRO-I-RXN""}, {""id"": ""MetaCyc:PWY-6703"", ""source_sha256"": ""6ceddf0ef319853b2f7cbb8deebdb06f0f643fb6d256d79ce2cddb108d019db7"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers complete XML response body"", ""title"": ""MetaCyc PWY-6703 original native object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6703""}, {""id"": ""RHEA:17473"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 17473 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-036_adff7cbe49c4	RHEA:27967	BFO:0000050	GO:0097288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6703|MetaCyc:RXN0-5507|RHEA:27966	This is one complete native transformation in the exact PreQ0-forming process.	"[{""reference_id"": ""MetaCyc:PWY-6703"", ""source_assertion"": ""PWY-6703 explicitly lists RXN0-5507 among its four reaction members."", ""source_locator"": ""Pathway[@frameid=\""PWY-6703\""]/reaction-list""}, {""reference_id"": ""MetaCyc:RXN0-5507"", ""source_assertion"": ""The native reaction explicitly cross-references Rhea 27967; its source direction is LEFT-TO-RIGHT."", ""source_locator"": ""Reaction[@frameid=\""RXN0-5507\""]/dblink[dblink-db=\""RHEA\""]; reaction-direction""}, {""reference_id"": ""RHEA:27966"", ""source_assertion"": ""Master RHEA:27966 declares RHEA:27967 as a directional reaction; the selected full RDF equation is the source for its chemistry."", ""source_locator"": ""http://rdf.rhea-db.org/27966 rh:directionalReaction; http://rdf.rhea-db.org/27967 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6703"", ""source_sha256"": ""6ceddf0ef319853b2f7cbb8deebdb06f0f643fb6d256d79ce2cddb108d019db7"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers complete XML response body"", ""title"": ""MetaCyc PWY-6703 original native object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6703""}, {""id"": ""MetaCyc:RXN0-5507"", ""source_sha256"": ""973708d043c60f9865f826381fd6f6f52f0a8a2a8915795967baaa5473ef1d30"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers complete XML response body"", ""title"": ""MetaCyc RXN0-5507 original native object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5507""}, {""id"": ""RHEA:27966"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27966 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-037_70004852ecf8	RHEA:27975	BFO:0000050	GO:0097288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6703|MetaCyc:RXN0-6575|RHEA:27974	This is one complete native transformation in the exact PreQ0-forming process.	"[{""reference_id"": ""MetaCyc:PWY-6703"", ""source_assertion"": ""PWY-6703 explicitly lists RXN0-6575 among its four reaction members."", ""source_locator"": ""Pathway[@frameid=\""PWY-6703\""]/reaction-list""}, {""reference_id"": ""MetaCyc:RXN0-6575"", ""source_assertion"": ""The native reaction explicitly cross-references Rhea 27975; its source direction is LEFT-TO-RIGHT."", ""source_locator"": ""Reaction[@frameid=\""RXN0-6575\""]/dblink[dblink-db=\""RHEA\""]; reaction-direction""}, {""reference_id"": ""RHEA:27974"", ""source_assertion"": ""Master RHEA:27974 declares RHEA:27975 as a directional reaction; the selected full RDF equation is the source for its chemistry."", ""source_locator"": ""http://rdf.rhea-db.org/27974 rh:directionalReaction; http://rdf.rhea-db.org/27975 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6703"", ""source_sha256"": ""6ceddf0ef319853b2f7cbb8deebdb06f0f643fb6d256d79ce2cddb108d019db7"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers complete XML response body"", ""title"": ""MetaCyc PWY-6703 original native object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6703""}, {""id"": ""MetaCyc:RXN0-6575"", ""source_sha256"": ""5386b26f34432163fcb28832ff0d7311280a9b43a942c00e65a343a0d684e3e3"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers complete XML response body"", ""title"": ""MetaCyc RXN0-6575 original native object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-6575""}, {""id"": ""RHEA:27974"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27974 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-038_c0a587e54649	RHEA:27983	BFO:0000050	GO:0097288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6703|MetaCyc:RXN-12093|RHEA:27982	This is one complete native transformation in the exact PreQ0-forming process. The preserved native cross-reference identifies the updated reaction, but MetaCyc 22.5 retains an obsolete one-ATP/ADP equation; current Rhea 142 supplies the chemistry.	"[{""reference_id"": ""MetaCyc:PWY-6703"", ""source_assertion"": ""PWY-6703 explicitly lists RXN-12093 among its four reaction members."", ""source_locator"": ""Pathway[@frameid=\""PWY-6703\""]/reaction-list""}, {""reference_id"": ""MetaCyc:RXN-12093"", ""source_assertion"": ""The native reaction explicitly cross-references Rhea 27983; its source direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""Reaction[@frameid=\""RXN-12093\""]/dblink[dblink-db=\""RHEA\""]; reaction-direction""}, {""reference_id"": ""RHEA:27982"", ""source_assertion"": ""Master RHEA:27982 declares RHEA:27983 as a directional reaction; the selected full RDF equation is the source for its chemistry. The current equation has two ATP, two AMP and two diphosphate."", ""source_locator"": ""http://rdf.rhea-db.org/27982 rh:directionalReaction; http://rdf.rhea-db.org/27983 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6703"", ""source_sha256"": ""6ceddf0ef319853b2f7cbb8deebdb06f0f643fb6d256d79ce2cddb108d019db7"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers complete XML response body"", ""title"": ""MetaCyc PWY-6703 original native object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6703""}, {""id"": ""MetaCyc:RXN-12093"", ""source_sha256"": ""2a03b391731384e57ecc86d7e18425ff61df5067f5ff62be4d6ec48c4a04f3da"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers complete XML response body"", ""title"": ""MetaCyc RXN-12093 original native object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-12093""}, {""id"": ""RHEA:27982"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27982 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-039_0d1ac4f104ea	RHEA:17474	RO:0002413	RHEA:27967	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17473|RHEA:27966	The exact charged intermediate connects the two selected biosynthetic reactions; there is no additional net or decomposition reaction.	"[{""reference_id"": ""RHEA:17473"", ""source_assertion"": ""RHEA:17474 produces CHEBI:58462."", ""source_locator"": ""http://rdf.rhea-db.org/17474 rh:products; http://rdf.rhea-db.org/17473_R rh:contains1 http://rdf.rhea-db.org/Participant_17473_compound_2443; rh:compound http://rdf.rhea-db.org/Compound_2443; rh:accession""}, {""reference_id"": ""RHEA:27966"", ""source_assertion"": ""RHEA:27967 consumes CHEBI:58462."", ""source_locator"": ""http://rdf.rhea-db.org/27967 rh:substrates; http://rdf.rhea-db.org/27966_L rh:contains1 http://rdf.rhea-db.org/Participant_27966_compound_2443; rh:compound http://rdf.rhea-db.org/Compound_2443; rh:accession""}]"	"[{""id"": ""RHEA:17473"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 17473 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:27966"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27966 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-040_02620076c9a3	RHEA:27967	RO:0002413	RHEA:27975	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27966|RHEA:27974	The exact charged intermediate connects the two selected biosynthetic reactions; there is no additional net or decomposition reaction.	"[{""reference_id"": ""RHEA:27966"", ""source_assertion"": ""RHEA:27967 produces CHEBI:61032."", ""source_locator"": ""http://rdf.rhea-db.org/27967 rh:products; http://rdf.rhea-db.org/27966_R rh:contains1 http://rdf.rhea-db.org/Participant_27966_compound_6305; rh:compound http://rdf.rhea-db.org/Compound_6305; rh:accession""}, {""reference_id"": ""RHEA:27974"", ""source_assertion"": ""RHEA:27975 consumes CHEBI:61032."", ""source_locator"": ""http://rdf.rhea-db.org/27975 rh:substrates; http://rdf.rhea-db.org/27974_L rh:contains1 http://rdf.rhea-db.org/Participant_27974_compound_6305; rh:compound http://rdf.rhea-db.org/Compound_6305; rh:accession""}]"	"[{""id"": ""RHEA:27966"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27966 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:27974"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27974 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0097288_preq0-edge-041_6cbaf217baff	RHEA:27975	RO:0002413	RHEA:27983	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27974|RHEA:27982	The exact charged intermediate connects the two selected biosynthetic reactions; there is no additional net or decomposition reaction.	"[{""reference_id"": ""RHEA:27974"", ""source_assertion"": ""RHEA:27975 produces CHEBI:61036."", ""source_locator"": ""http://rdf.rhea-db.org/27975 rh:products; http://rdf.rhea-db.org/27974_R rh:contains1 http://rdf.rhea-db.org/Participant_27974_compound_6307; rh:compound http://rdf.rhea-db.org/Compound_6307; rh:accession""}, {""reference_id"": ""RHEA:27982"", ""source_assertion"": ""RHEA:27983 consumes CHEBI:61036."", ""source_locator"": ""http://rdf.rhea-db.org/27983 rh:substrates; http://rdf.rhea-db.org/27982_L rh:contains1 http://rdf.rhea-db.org/Participant_27982_compound_6307; rh:compound http://rdf.rhea-db.org/Compound_6307; rh:accession""}]"	"[{""id"": ""RHEA:27974"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27974 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:27982"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers complete compressed RDF archive"", ""title"": ""Rhea 27982 original reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1312_edge-001_67be09f1d551	CHEBI:43474	pathwaymech:consumes	RHEA:19522	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19522		"[{""reference_id"": ""RHEA:19522"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the substrates side of RHEA:19522 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19522']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19522"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right phosphate acetyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/19522""}]"	""
pathwaymech:MetaCyc_PWY0-1312_edge-002_42b1c35cf48f	CHEBI:57288	pathwaymech:consumes	RHEA:19522	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19522		"[{""reference_id"": ""RHEA:19522"", ""source_assertion"": ""Rhea lists CHEBI:57288 on the substrates side of RHEA:19522 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19522']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19522"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right phosphate acetyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/19522""}]"	""
pathwaymech:MetaCyc_PWY0-1312_edge-003_9f342253fdef	RHEA:19522	pathwaymech:produces	CHEBI:22191	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19522		"[{""reference_id"": ""RHEA:19522"", ""source_assertion"": ""Rhea lists CHEBI:22191 on the products side of RHEA:19522 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19522']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19522"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right phosphate acetyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/19522""}]"	""
pathwaymech:MetaCyc_PWY0-1312_edge-004_4ebb40feb3f0	RHEA:19522	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19522		"[{""reference_id"": ""RHEA:19522"", ""source_assertion"": ""Rhea lists CHEBI:57287 on the products side of RHEA:19522 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19522']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19522"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right phosphate acetyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/19522""}]"	""
pathwaymech:MetaCyc_PWY0-1312_edge-005_d3d36fe2bfbc	CHEBI:22191	pathwaymech:consumes	RHEA:11354	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11354		"[{""reference_id"": ""RHEA:11354"", ""source_assertion"": ""Rhea lists CHEBI:22191 on the substrates side of RHEA:11354 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11354']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11354"", ""source_version"": ""139"", ""title"": ""Rhea acetyl phosphate-to-acetate kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/11354""}]"	""
pathwaymech:MetaCyc_PWY0-1312_edge-006_66d123dca8ba	CHEBI:456216	pathwaymech:consumes	RHEA:11354	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11354		"[{""reference_id"": ""RHEA:11354"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the substrates side of RHEA:11354 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11354']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11354"", ""source_version"": ""139"", ""title"": ""Rhea acetyl phosphate-to-acetate kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/11354""}]"	""
pathwaymech:MetaCyc_PWY0-1312_edge-007_55f4fc180c27	RHEA:11354	pathwaymech:produces	CHEBI:30089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11354		"[{""reference_id"": ""RHEA:11354"", ""source_assertion"": ""Rhea lists CHEBI:30089 on the products side of RHEA:11354 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11354']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11354"", ""source_version"": ""139"", ""title"": ""Rhea acetyl phosphate-to-acetate kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/11354""}]"	""
pathwaymech:MetaCyc_PWY0-1312_edge-008_81f99ae2dc5c	RHEA:11354	pathwaymech:produces	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11354		"[{""reference_id"": ""RHEA:11354"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the products side of RHEA:11354 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11354']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11354"", ""source_version"": ""139"", ""title"": ""Rhea acetyl phosphate-to-acetate kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/11354""}]"	""
pathwaymech:MetaCyc_PWY0-1312_edge-009_1103c2929fe8	EC:2.3.1.8	pathwaymech:catalyzes	RHEA:19522	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:10074080|RHEA:19521		"[{""reference_id"": ""RHEA:19521"", ""source_assertion"": ""Rhea associates EC:2.3.1.8 with the reaction family containing RHEA:19522."", ""source_locator"": ""rh:ec""}, {""quote"": ""Phosphate acetyltransferase (PTA) and acetate kinase (AK) of the hyperthermophilic eubacterium Thermotoga maritima have been purified 1,500- and 250-fold, respectively, to apparent homogeneity."", ""reference_id"": ""PMID:10074080"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Bock et al., Journal of Bacteriology, 1999"", ""id"": ""PMID:10074080"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/10074080/""}, {""id"": ""RHEA:19521"", ""source_version"": ""139"", ""title"": ""Rhea phosphate acetyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/19521""}]"	""
pathwaymech:MetaCyc_PWY0-1312_edge-010_6bb2a0b783d9	EC:2.7.2.1	pathwaymech:catalyzes	RHEA:11354	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:10074080|RHEA:11352		"[{""reference_id"": ""RHEA:11352"", ""source_assertion"": ""Rhea associates EC:2.7.2.1 with the reaction family containing RHEA:11354."", ""source_locator"": ""rh:ec""}, {""quote"": ""Phosphate acetyltransferase (PTA) and acetate kinase (AK) of the hyperthermophilic eubacterium Thermotoga maritima have been purified 1,500- and 250-fold, respectively, to apparent homogeneity."", ""reference_id"": ""PMID:10074080"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Bock et al., Journal of Bacteriology, 1999"", ""id"": ""PMID:10074080"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/10074080/""}, {""id"": ""RHEA:11352"", ""source_version"": ""139"", ""title"": ""Rhea acetate kinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/11352""}]"	""
pathwaymech:MetaCyc_PWY0-1312_edge-011_8eeea19e1e06	RHEA:19522	pathwaymech:precedes	RHEA:11354	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1312		"[{""reference_id"": ""MetaCyc:PWY0-1312"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:19522 before RHEA:11354 in this pathway. Shared intermediate: CHEBI:22191."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY0-1312"", ""source_sha256"": ""a0839116193214c280c3e61b52b5599ec5aee54b619e83d1e9b3205e046431ef"", ""source_version"": ""22.5"", ""title"": ""MetaCyc acetate and ATP formation from acetyl-CoA I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY0-1312&detail=full""}]"	""
pathwaymech:MetaCyc_PWY0-1312_edge-012_be7615618a38	UniProtKB:Q9WYB1	pathwaymech:enables	RHEA:11354	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q9WYB1		"[{""reference_id"": ""UniProtKB:Q9WYB1"", ""source_assertion"": ""UniProt annotates UniProtKB:Q9WYB1 with catalytic activity for the reaction family of RHEA:11354. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:243274."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:Q9WYB1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:Q9WYB1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9WYB1.json""}]"	""
pathwaymech:MetaCyc_PWY0-1312_edge-013_a6370865c374	UniProtKB:Q9WYB1	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q9WYB1		"[{""reference_id"": ""UniProtKB:Q9WYB1"", ""source_assertion"": ""UniProt locates UniProtKB:Q9WYB1 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:Q9WYB1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:Q9WYB1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9WYB1.json""}]"	""
pathwaymech:MetaCyc_PWY0-1312_edge-014_e3956a537612	UniProtKB:Q9WYB1	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q9WYB1		"[{""reference_id"": ""UniProtKB:Q9WYB1"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:Q9WYB1 (evidence: ECO:0000255, ECO:0000269). Mg(2+). Can also accept Mn(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:Q9WYB1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:Q9WYB1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9WYB1.json""}]"	""
pathwaymech:MetaCyc_PWY0-1312_edge-015_6e72ede702f5	UniProtKB:Q9WYB1	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q9WYB1		"[{""reference_id"": ""UniProtKB:Q9WYB1"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:Q9WYB1 (evidence: ECO:0000255, ECO:0000269). Mg(2+). Can also accept Mn(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:Q9WYB1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:Q9WYB1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9WYB1.json""}]"	""
pathwaymech:MetaCyc_PWY0-1312_edge-016_996bba4decdc	UniProtKB:Q9X0L4	pathwaymech:enables	RHEA:19522	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q9X0L4		"[{""reference_id"": ""UniProtKB:Q9X0L4"", ""source_assertion"": ""UniProt annotates UniProtKB:Q9X0L4 with catalytic activity for the reaction family of RHEA:19522. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:243274."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:Q9X0L4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:Q9X0L4 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9X0L4.json""}]"	""
pathwaymech:MetaCyc_PWY0-1312_edge-017_7b367fb9bfd8	UniProtKB:Q9X0L4	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q9X0L4		"[{""reference_id"": ""UniProtKB:Q9X0L4"", ""source_assertion"": ""UniProt locates UniProtKB:Q9X0L4 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:Q9X0L4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:Q9X0L4 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9X0L4.json""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-1_cb962cb5114a	CHEBI:15350	pathwaymech:consumes	WikiPathways:WP5019/e7431	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML e7431 connects normalized CHEBI:15350 as an input of interaction e7431."", ""source_locator"": ""/Pathway/Interaction[@GraphId='e7431']/Graphics; /Pathway/DataNode[@GraphId='b4740']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-2_4675fd6e841f	WikiPathways:WP5019/e7431	pathwaymech:produces	CHEBI:30089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML e7431 connects normalized CHEBI:30089 as an output of interaction e7431."", ""source_locator"": ""/Pathway/Interaction[@GraphId='e7431']/Graphics; /Pathway/DataNode[@GraphId='d0ddf']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-3_2830e402befa	CHEBI:15638	pathwaymech:consumes	WikiPathways:WP5019/id192c7b4a	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id192c7b4a connects normalized CHEBI:15638 as an input of interaction id192c7b4a."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id192c7b4a']/Graphics; /Pathway/DataNode[@GraphId='e2598']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-4_80809ef40de0	WikiPathways:WP5019/id192c7b4a	pathwaymech:produces	CHEBI:1989	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id192c7b4a connects normalized CHEBI:1989 as an output of interaction id192c7b4a."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id192c7b4a']/Graphics; /Pathway/DataNode[@GraphId='c1016']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-5_c6b440440c23	CHEBI:16526	pathwaymech:consumes	WikiPathways:WP5019/id48aa4469	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id48aa4469 connects normalized CHEBI:16526 as an input of interaction id48aa4469."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id48aa4469']/Graphics; /Pathway/DataNode[@GraphId='fe5e2']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-6_deec580822ff	WikiPathways:WP5019/id48aa4469	pathwaymech:produces	CHEBI:17245	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id48aa4469 connects normalized CHEBI:17245 as an output of interaction id48aa4469."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id48aa4469']/Graphics; /Pathway/DataNode[@GraphId='dcb01']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-7_b42e73b92e9c	CHEBI:15351	pathwaymech:consumes	WikiPathways:WP5019/id48bab90b	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id48bab90b connects normalized CHEBI:15351 as an input of interaction id48bab90b."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id48bab90b']/Graphics; /Pathway/DataNode[@GraphId='f601f']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-8_c24d9ae8ccbf	WikiPathways:WP5019/id48bab90b	pathwaymech:produces	CHEBI:15350	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id48bab90b connects normalized CHEBI:15350 as an output of interaction id48bab90b."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id48bab90b']/Graphics; /Pathway/DataNode[@GraphId='b4740']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-9_88cdc90efa75	CHEBI:17908	pathwaymech:consumes	WikiPathways:WP5019/id4f3af248	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id4f3af248 connects normalized CHEBI:17908 as an input of interaction id4f3af248."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id4f3af248']/Graphics; /Pathway/DataNode[@GraphId='afcfe']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-10_a88ff3762745	WikiPathways:WP5019/id4f3af248	pathwaymech:produces	CHEBI:17513	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id4f3af248 connects normalized CHEBI:17513 as an output of interaction id4f3af248."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id4f3af248']/Graphics; /Pathway/DataNode[@GraphId='f1eb8']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-11_13ec6ca1f0ab	CHEBI:15637	pathwaymech:consumes	WikiPathways:WP5019/id59fbd0e3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id59fbd0e3 connects normalized CHEBI:15637 as an input of interaction id59fbd0e3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id59fbd0e3']/Graphics; /Pathway/DataNode[@GraphId='f0345']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-12_21b5a1b2fcd4	WikiPathways:WP5019/id59fbd0e3	pathwaymech:produces	CHEBI:15638	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id59fbd0e3 connects normalized CHEBI:15638 as an output of interaction id59fbd0e3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id59fbd0e3']/Graphics; /Pathway/DataNode[@GraphId='e2598']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-13_beb69ce7a5d8	CHEBI:57540	pathwaymech:consumes	WikiPathways:WP5019/idb70e2922	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML idb70e2922 connects normalized CHEBI:57540 as an input of interaction idb70e2922."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idb70e2922']/Graphics; /Pathway/DataNode[@GraphId='fc35e']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-14_b9a84be457e8	WikiPathways:WP5019/idb70e2922	pathwaymech:produces	CHEBI:16908	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML idb70e2922 connects normalized CHEBI:16908 as an output of interaction idb70e2922."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idb70e2922']/Graphics; /Pathway/DataNode[@GraphId='ac93a']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-15_3f3dcd80c216	CHEBI:15740	pathwaymech:consumes	WikiPathways:WP5019/idcb0cc195	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML idcb0cc195 connects normalized CHEBI:15740 as an input of interaction idcb0cc195."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idcb0cc195']/Graphics; /Pathway/DataNode[@GraphId='a4940']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-16_0ed62d486a73	WikiPathways:WP5019/idcb0cc195	pathwaymech:produces	CHEBI:15637	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML idcb0cc195 connects normalized CHEBI:15637 as an output of interaction idcb0cc195."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idcb0cc195']/Graphics; /Pathway/DataNode[@GraphId='f0345']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-17_e82f4fd7039b	CHEBI:1989	pathwaymech:consumes	WikiPathways:WP5019/ide2e37f0	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML ide2e37f0 connects normalized CHEBI:1989 as an input of interaction ide2e37f0."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ide2e37f0']/Graphics; /Pathway/DataNode[@GraphId='c1016']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-18_0c2196ee420d	WikiPathways:WP5019/ide2e37f0	pathwaymech:produces	CHEBI:15641	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML ide2e37f0 connects normalized CHEBI:15641 as an output of interaction ide2e37f0."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ide2e37f0']/Graphics; /Pathway/DataNode[@GraphId='aed66']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-19_713feaa6b422	CHEBI:17245	pathwaymech:consumes	WikiPathways:WP5019/ideb932d04	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML ideb932d04 connects normalized CHEBI:17245 as an input of interaction ideb932d04."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ideb932d04']/Graphics; /Pathway/DataNode[@GraphId='dcb01']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-20_0accf48a984f	WikiPathways:WP5019/ideb932d04	pathwaymech:produces	CHEBI:15351	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML ideb932d04 connects normalized CHEBI:15351 as an output of interaction ideb932d04."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ideb932d04']/Graphics; /Pathway/DataNode[@GraphId='f601f']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-21_b9a1e46b634d	CHEBI:16526	pathwaymech:consumes	WikiPathways:WP5019/idee9950c3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML idee9950c3 connects normalized CHEBI:16526 as an input of interaction idee9950c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idee9950c3']/Graphics; /Pathway/DataNode[@GraphId='dca37']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-22_cd9250aaf3cf	WikiPathways:WP5019/idee9950c3	pathwaymech:produces	CHEBI:15740	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML idee9950c3 connects normalized CHEBI:15740 as an output of interaction idee9950c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idee9950c3']/Graphics; /Pathway/DataNode[@GraphId='a4940']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-23_79048a16555a	CHEBI:18276	pathwaymech:consumes	WikiPathways:WP5019/idf6f6d75	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML idf6f6d75 connects normalized CHEBI:18276 as an input of interaction idf6f6d75."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idf6f6d75']/Graphics; /Pathway/DataNode[@GraphId='b7200']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-24_13b56a7bd05b	WikiPathways:WP5019/idf6f6d75	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML idf6f6d75 connects normalized CHEBI:15378 as an output of interaction idf6f6d75."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idf6f6d75']/Graphics; /Pathway/DataNode[@GraphId='e4d29']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-25_d870919b6372	WikiPathways:WP5019/e7431	pathwaymech:produces	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id275b32d7 connects normalized CHEBI:30616 as an output of interaction e7431."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id275b32d7']/Graphics; /Pathway/DataNode[@GraphId='cc2f1']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-26_be5bc59fe719	WikiPathways:WP5019/id48aa4469	pathwaymech:produces	CHEBI:17908	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id2f21bbbe connects normalized CHEBI:17908 as an output of interaction id48aa4469."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id2f21bbbe']/Graphics; /Pathway/DataNode[@GraphId='afcfe']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-27_d16ffd970acc	UniProtKB:H6LJY6	pathwaymech:catalyzes	WikiPathways:WP5019/id48bab90b	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id43d52636 connects normalized UniProtKB:H6LJY6 as a catalyst of interaction id48bab90b."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id43d52636']/Graphics; /Pathway/DataNode[@GraphId='ede55']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-28_55ca12018b81	WikiPathways:WP5019/ide2e37f0	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id5622490f connects normalized CHEBI:57540 as an output of interaction ide2e37f0."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5622490f']/Graphics; /Pathway/DataNode[@GraphId='fc35e']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-29_bc4ea9d0c624	WikiPathways:WP5019/idcb0cc195	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id5767ed45 connects normalized CHEBI:43474 as an output of interaction idcb0cc195."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5767ed45']/Graphics; /Pathway/DataNode[@GraphId='f6014']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-30_f2c7dffa2cd4	UniProtKB:H6LB59	pathwaymech:enables	WikiPathways:WP5019/idee9950c3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id58e440b7 connects normalized UniProtKB:H6LB59 as an enabling enzyme component of interaction idee9950c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id58e440b7']/Graphics; /Pathway/DataNode[@GraphId='b132a']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-31_6739ed6fb26e	UniProtKB:H6LB60	pathwaymech:enables	WikiPathways:WP5019/idee9950c3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id58e440b7 connects normalized UniProtKB:H6LB60 as an enabling enzyme component of interaction idee9950c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id58e440b7']/Graphics; /Pathway/DataNode[@GraphId='c8972']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-32_4541588a3da7	UniProtKB:H6LB64	pathwaymech:enables	WikiPathways:WP5019/idee9950c3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id58e440b7 connects normalized UniProtKB:H6LB64 as an enabling enzyme component of interaction idee9950c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id58e440b7']/Graphics; /Pathway/DataNode[@GraphId='ed8bc']""}, {""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id9ab97d5f connects normalized UniProtKB:H6LB64 as an enabling enzyme component of interaction idee9950c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id9ab97d5f']/Graphics; /Pathway/DataNode[@GraphId='e5a95']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-33_8dfe62879071	UniProtKB:H6LB65	pathwaymech:enables	WikiPathways:WP5019/idee9950c3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id58e440b7 connects normalized UniProtKB:H6LB65 as an enabling enzyme component of interaction idee9950c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id58e440b7']/Graphics; /Pathway/DataNode[@GraphId='ee690']""}, {""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id9ab97d5f connects normalized UniProtKB:H6LB65 as an enabling enzyme component of interaction idee9950c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id9ab97d5f']/Graphics; /Pathway/DataNode[@GraphId='b2df1']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-34_2c1291083b1a	UniProtKB:H6LFG4	pathwaymech:catalyzes	WikiPathways:WP5019/idb70e2922	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id752f0f0e connects normalized UniProtKB:H6LFG4 as a catalyst of interaction idb70e2922."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id752f0f0e']/Graphics; /Pathway/DataNode[@GraphId='c50df']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-35_05a88df8c3ed	UniProtKB:H6LFG3	pathwaymech:catalyzes	WikiPathways:WP5019/idf6f6d75	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id84c19ee7 connects normalized UniProtKB:H6LFG3 as a catalyst of interaction idf6f6d75."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id84c19ee7']/Graphics; /Pathway/DataNode[@GraphId='e7d5b']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-36_980ec8dcd165	WikiPathways:WP5019/id48bab90b	pathwaymech:produces	CHEBI:15346	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id8e876ee4 connects normalized CHEBI:15346 as an output of interaction id48bab90b."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id8e876ee4']/Graphics; /Pathway/DataNode[@GraphId='baa9c']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-37_3740c98522ab	UniProtKB:H6LBE7	pathwaymech:catalyzes	WikiPathways:WP5019/e7431	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id8ed8b579 connects normalized UniProtKB:H6LBE7 as a catalyst of interaction e7431."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id8ed8b579']/Graphics; /Pathway/DataNode[@GraphId='e5ea4']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-38_905315eefc11	WikiPathways:WP5019/id192c7b4a	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id927fb03c connects normalized CHEBI:57540 as an output of interaction id192c7b4a."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id927fb03c']/Graphics; /Pathway/DataNode[@GraphId='fc35e']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-39_9e5f7168bfa0	UniProtKB:H6LB62	pathwaymech:enables	WikiPathways:WP5019/idee9950c3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id9ab97d5f connects normalized UniProtKB:H6LB62 as an enabling enzyme component of interaction idee9950c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id9ab97d5f']/Graphics; /Pathway/DataNode[@GraphId='bf4ae']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-40_2913da7a32ce	UniProtKB:H6LB61	pathwaymech:enables	WikiPathways:WP5019/idee9950c3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id9ab97d5f connects normalized UniProtKB:H6LB61 as an enabling enzyme component of interaction idee9950c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id9ab97d5f']/Graphics; /Pathway/DataNode[@GraphId='c83d5']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-41_3ee7bdfc5ae5	UniProtKB:H6LFG4	pathwaymech:catalyzes	WikiPathways:WP5019/id4f3af248	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML idba9e932 connects normalized UniProtKB:H6LFG4 as a catalyst of interaction id4f3af248."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idba9e932']/Graphics; /Pathway/DataNode[@GraphId='c50df']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-42_b4fdaf37a033	WikiPathways:WP5019/idee9950c3	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML idbe118003 connects normalized CHEBI:15378 as an output of interaction idee9950c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idbe118003']/Graphics; /Pathway/DataNode[@GraphId='a8764']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-43_a901fd1385e9	WikiPathways:WP5019/idcb0cc195	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML idbf2124e2 connects normalized CHEBI:456216 as an output of interaction idcb0cc195."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idbf2124e2']/Graphics; /Pathway/DataNode[@GraphId='bd02e']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-44_bdf7c6422759	UniProtKB:H6LBX5	pathwaymech:catalyzes	WikiPathways:WP5019/id59fbd0e3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML f45ef connects normalized UniProtKB:H6LBX5 as a catalyst of interaction id59fbd0e3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='f45ef']/Graphics; /Pathway/DataNode[@GraphId='c9408']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-45_4dac9a491e47	UniProtKB:H6LBX4	pathwaymech:catalyzes	WikiPathways:WP5019/idcb0cc195	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML cb0d1 connects normalized UniProtKB:H6LBX4 as a catalyst of interaction idcb0cc195."", ""source_locator"": ""/Pathway/Interaction[@GraphId='cb0d1']/Graphics; /Pathway/DataNode[@GraphId='b6cbe']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-46_42eeae837937	UniProtKB:H6LBX6	pathwaymech:catalyzes	WikiPathways:WP5019/id192c7b4a	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML cffef connects normalized UniProtKB:H6LBX6 as a catalyst of interaction id192c7b4a."", ""source_locator"": ""/Pathway/Interaction[@GraphId='cffef']/Graphics; /Pathway/DataNode[@GraphId='c7e4d']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-47_4ba57185258d	UniProtKB:H6LD21	pathwaymech:catalyzes	WikiPathways:WP5019/id48aa4469	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML c0c8c connects normalized UniProtKB:H6LD21 as a catalyst of interaction id48aa4469."", ""source_locator"": ""/Pathway/Interaction[@GraphId='c0c8c']/Graphics; /Pathway/DataNode[@GraphId='de84f']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-48_c981fb68589d	CHEBI:17513	pathwaymech:consumes	WikiPathways:WP5019/id48aa4469	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019		"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML ad38c connects normalized CHEBI:17513 as an input of interaction id48aa4469."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ad38c']/Graphics; /Pathway/DataNode[@GraphId='f1eb8']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-49_fa34f8585af9	CHEBI:15641	pathwaymech:consumes	WikiPathways:WP5019/ideb932d04	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019	Aggregate of native corrinoid-bound methyl transfer and acetyl-CoA assembly; free methyl radical is not an intermediate.	"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id8e976caf connects normalized CHEBI:15641 as an input of interaction ideb932d04."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id8e976caf']/Graphics; /Pathway/DataNode[@GraphId='aed66']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-50_8e6908a75183	CHEBI:15346	pathwaymech:consumes	WikiPathways:WP5019/ideb932d04	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019	Aggregate of native corrinoid-bound methyl transfer and acetyl-CoA assembly; free methyl radical is not an intermediate.	"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id2b845640 connects normalized CHEBI:15346 as an input of interaction ideb932d04."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id2b845640']/Graphics; /Pathway/DataNode[@GraphId='baa9c']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-51_f0811dce1c55	WikiPathways:WP5019/ideb932d04	pathwaymech:produces	CHEBI:20506	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019	Aggregate of native corrinoid-bound methyl transfer and acetyl-CoA assembly; free methyl radical is not an intermediate.	"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id8e976caf connects normalized CHEBI:20506 as an output of interaction ideb932d04."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id8e976caf']/Graphics; /Pathway/DataNode[@GraphId='f4118']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-52_b98a333d7d07	UniProtKB:H6LD20	pathwaymech:enables	WikiPathways:WP5019/ideb932d04	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019	Component of the combined corrinoid methyl transfer/acetyl-CoA assembly, not an independently catalytic complex subunit.	"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id8e976caf connects normalized UniProtKB:H6LD20 as an enabling enzyme component of interaction ideb932d04."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id8e976caf']/Graphics; /Pathway/DataNode[@GraphId='b31af']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-53_22b9178665a1	UniProtKB:H6LD23	pathwaymech:enables	WikiPathways:WP5019/ideb932d04	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019	Component of the combined corrinoid methyl transfer/acetyl-CoA assembly, not an independently catalytic complex subunit.	"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML ideb932d04 connects normalized UniProtKB:H6LD23 as an enabling enzyme component of interaction ideb932d04."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ideb932d04']/Graphics; /Pathway/DataNode[@GraphId='c0d75']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-54_37af11047818	UniProtKB:H6LD18	pathwaymech:enables	WikiPathways:WP5019/ideb932d04	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019	Component of the combined corrinoid methyl transfer/acetyl-CoA assembly, not an independently catalytic complex subunit.	"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id8e976caf connects normalized UniProtKB:H6LD18 as an enabling enzyme component of interaction ideb932d04."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id8e976caf']/Graphics; /Pathway/DataNode[@GraphId='f37ef']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_causal-review-55_5ab10fc91744	UniProtKB:H6LD19	pathwaymech:enables	WikiPathways:WP5019/ideb932d04	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5019	Component of the combined corrinoid methyl transfer/acetyl-CoA assembly, not an independently catalytic complex subunit.	"[{""reference_id"": ""WikiPathways:WP5019"", ""source_assertion"": ""GPML id8e976caf connects normalized UniProtKB:H6LD19 as an enabling enzyme component of interaction ideb932d04."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id8e976caf']/Graphics; /Pathway/DataNode[@GraphId='d0c8a']""}]"	"[{""id"": ""WikiPathways:WP5019"", ""source_sha256"": ""6e9813b9ec10cf602774230591614b93cc000004b2c91e241ab253239f47924a"", ""source_version"": ""WP5019_r139978"", ""title"": ""WP5019 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5019/WP5019.gpml""}]"	""
pathwaymech:WikiPathways_WP5019_cofactor-193dd62695f8_99cf3f8ea6c1	UniProtKB:H6LD21	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:H6LD21	UniProtKB unreviewed (TrEMBL) annotation. UniProt evidence: ECO:0000256 (ARBA:ARBA00001966)	"[{""reference_id"": ""UniProtKB:H6LD21"", ""source_assertion"": ""UniProtKB:H6LD21 annotates CHEBI:49883 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AH6LB59+OR+accession%3AH6LB60+OR+accession%3AH6LB61+OR+accession%3AH6LB62+OR+accession%3AH6LB64+OR+accession%3AH6LB65+OR+accession%3AH6LBE7+OR+accession%3AH6LBX4+OR+accession%3AH6LBX5+OR+accession%3AH6LBX6+OR+accession%3AH6LD21+OR+accession%3AH6LFG3+OR+accession%3AH6LFG4+OR+accession%3AH6LJY6+OR+accession%3AP9WJN3&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:58c69edf7b795ede960dadfaf0093c56d2e871e90536ef0184f021222ecc1321] #/results/6/comments/0/cofactors/0""}]"	"[{""id"": ""UniProtKB:H6LD21"", ""source_sha256"": ""58c69edf7b795ede960dadfaf0093c56d2e871e90536ef0184f021222ecc1321"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB H6LD21 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AH6LB59+OR+accession%3AH6LB60+OR+accession%3AH6LB61+OR+accession%3AH6LB62+OR+accession%3AH6LB64+OR+accession%3AH6LB65+OR+accession%3AH6LBE7+OR+accession%3AH6LBX4+OR+accession%3AH6LBX5+OR+accession%3AH6LBX6+OR+accession%3AH6LD21+OR+accession%3AH6LFG3+OR+accession%3AH6LFG4+OR+accession%3AH6LJY6+OR+accession%3AP9WJN3&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5019_cofactor-a6e2ce943406_e1b235e2908a	UniProtKB:H6LFG3	pathwaymech:has_cofactor	CHEBI:190135	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:H6LFG3	UniProtKB unreviewed (TrEMBL) annotation. UniProt evidence: ECO:0000256 (ARBA:ARBA00034078)	"[{""reference_id"": ""UniProtKB:H6LFG3"", ""source_assertion"": ""UniProtKB:H6LFG3 annotates CHEBI:190135 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AH6LB59+OR+accession%3AH6LB60+OR+accession%3AH6LB61+OR+accession%3AH6LB62+OR+accession%3AH6LB64+OR+accession%3AH6LB65+OR+accession%3AH6LBE7+OR+accession%3AH6LBX4+OR+accession%3AH6LBX5+OR+accession%3AH6LBX6+OR+accession%3AH6LD21+OR+accession%3AH6LFG3+OR+accession%3AH6LFG4+OR+accession%3AH6LJY6+OR+accession%3AP9WJN3&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:58c69edf7b795ede960dadfaf0093c56d2e871e90536ef0184f021222ecc1321] #/results/7/comments/0/cofactors/0""}]"	"[{""id"": ""UniProtKB:H6LFG3"", ""source_sha256"": ""58c69edf7b795ede960dadfaf0093c56d2e871e90536ef0184f021222ecc1321"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB H6LFG3 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AH6LB59+OR+accession%3AH6LB60+OR+accession%3AH6LB61+OR+accession%3AH6LB62+OR+accession%3AH6LB64+OR+accession%3AH6LB65+OR+accession%3AH6LBE7+OR+accession%3AH6LBX4+OR+accession%3AH6LBX5+OR+accession%3AH6LBX6+OR+accession%3AH6LD21+OR+accession%3AH6LFG3+OR+accession%3AH6LFG4+OR+accession%3AH6LJY6+OR+accession%3AP9WJN3&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5019_cofactor-9f07ddcf6af5_24eed2cb2af6	UniProtKB:H6LFG3	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:H6LFG3	UniProtKB unreviewed (TrEMBL) annotation. UniProt evidence: ECO:0000256 (ARBA:ARBA00001966)	"[{""reference_id"": ""UniProtKB:H6LFG3"", ""source_assertion"": ""UniProtKB:H6LFG3 annotates CHEBI:49883 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AH6LB59+OR+accession%3AH6LB60+OR+accession%3AH6LB61+OR+accession%3AH6LB62+OR+accession%3AH6LB64+OR+accession%3AH6LB65+OR+accession%3AH6LBE7+OR+accession%3AH6LBX4+OR+accession%3AH6LBX5+OR+accession%3AH6LBX6+OR+accession%3AH6LD21+OR+accession%3AH6LFG3+OR+accession%3AH6LFG4+OR+accession%3AH6LJY6+OR+accession%3AP9WJN3&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:58c69edf7b795ede960dadfaf0093c56d2e871e90536ef0184f021222ecc1321] #/results/7/comments/1/cofactors/0""}]"	"[{""id"": ""UniProtKB:H6LFG3"", ""source_sha256"": ""58c69edf7b795ede960dadfaf0093c56d2e871e90536ef0184f021222ecc1321"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB H6LFG3 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AH6LB59+OR+accession%3AH6LB60+OR+accession%3AH6LB61+OR+accession%3AH6LB62+OR+accession%3AH6LB64+OR+accession%3AH6LB65+OR+accession%3AH6LBE7+OR+accession%3AH6LBX4+OR+accession%3AH6LBX5+OR+accession%3AH6LBX6+OR+accession%3AH6LD21+OR+accession%3AH6LFG3+OR+accession%3AH6LFG4+OR+accession%3AH6LJY6+OR+accession%3AP9WJN3&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5019_cofactor-8b0bf378cedd_3580490d738f	UniProtKB:H6LBE7	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:H6LBE7	UniProtKB unreviewed (TrEMBL) annotation. UniProt evidence: ECO:0000256 (HAMAP-Rule:MF_00020) Mg(2+). Can also accept Mn(2+). UniProt note evidence: ECO:0000256 (HAMAP-Rule:MF_00020)	"[{""reference_id"": ""UniProtKB:H6LBE7"", ""source_assertion"": ""UniProtKB:H6LBE7 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AH6LB59+OR+accession%3AH6LB60+OR+accession%3AH6LB61+OR+accession%3AH6LB62+OR+accession%3AH6LB64+OR+accession%3AH6LB65+OR+accession%3AH6LBE7+OR+accession%3AH6LBX4+OR+accession%3AH6LBX5+OR+accession%3AH6LBX6+OR+accession%3AH6LD21+OR+accession%3AH6LFG3+OR+accession%3AH6LFG4+OR+accession%3AH6LJY6+OR+accession%3AP9WJN3&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:58c69edf7b795ede960dadfaf0093c56d2e871e90536ef0184f021222ecc1321] #/results/1/comments/0/cofactors/0; /results/1/comments/0/note""}]"	"[{""id"": ""UniProtKB:H6LBE7"", ""source_sha256"": ""58c69edf7b795ede960dadfaf0093c56d2e871e90536ef0184f021222ecc1321"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB H6LBE7 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AH6LB59+OR+accession%3AH6LB60+OR+accession%3AH6LB61+OR+accession%3AH6LB62+OR+accession%3AH6LB64+OR+accession%3AH6LB65+OR+accession%3AH6LBE7+OR+accession%3AH6LBX4+OR+accession%3AH6LBX5+OR+accession%3AH6LBX6+OR+accession%3AH6LD21+OR+accession%3AH6LFG3+OR+accession%3AH6LFG4+OR+accession%3AH6LJY6+OR+accession%3AP9WJN3&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5019_cofactor-03fe539b3753_68422621672a	UniProtKB:H6LBE7	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:H6LBE7	UniProtKB unreviewed (TrEMBL) annotation. UniProt evidence: ECO:0000256 (HAMAP-Rule:MF_00020) Mg(2+). Can also accept Mn(2+). UniProt note evidence: ECO:0000256 (HAMAP-Rule:MF_00020)	"[{""reference_id"": ""UniProtKB:H6LBE7"", ""source_assertion"": ""UniProtKB:H6LBE7 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AH6LB59+OR+accession%3AH6LB60+OR+accession%3AH6LB61+OR+accession%3AH6LB62+OR+accession%3AH6LB64+OR+accession%3AH6LB65+OR+accession%3AH6LBE7+OR+accession%3AH6LBX4+OR+accession%3AH6LBX5+OR+accession%3AH6LBX6+OR+accession%3AH6LD21+OR+accession%3AH6LFG3+OR+accession%3AH6LFG4+OR+accession%3AH6LJY6+OR+accession%3AP9WJN3&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:58c69edf7b795ede960dadfaf0093c56d2e871e90536ef0184f021222ecc1321] #/results/1/comments/0/cofactors/1; /results/1/comments/0/note""}]"	"[{""id"": ""UniProtKB:H6LBE7"", ""source_sha256"": ""58c69edf7b795ede960dadfaf0093c56d2e871e90536ef0184f021222ecc1321"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB H6LBE7 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AH6LB59+OR+accession%3AH6LB60+OR+accession%3AH6LB61+OR+accession%3AH6LB62+OR+accession%3AH6LB64+OR+accession%3AH6LB65+OR+accession%3AH6LBE7+OR+accession%3AH6LBX4+OR+accession%3AH6LBX5+OR+accession%3AH6LBX6+OR+accession%3AH6LD21+OR+accession%3AH6LFG3+OR+accession%3AH6LFG4+OR+accession%3AH6LJY6+OR+accession%3AP9WJN3&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-001_f6e0f42537a8	CHEBI:16335	pathwaymech:consumes	RHEA:27643	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27643		"[{""reference_id"": ""RHEA:27643"", ""source_assertion"": ""RHEA:27643 substrates contain CHEBI:16335 with coefficient 1; the compound is adenosine."", ""source_locator"": ""rh:27643 rh:substrates <http://rdf.rhea-db.org/27642_L>; <http://rdf.rhea-db.org/27642_L> rh:contains1 <http://rdf.rhea-db.org/Participant_27642_compound_2547>; <http://rdf.rhea-db.org/Participant_27642_compound_2547> rh:compound <http://rdf.rhea-db.org/Compound_2547>; rh:accession/rh:formula/rh:charge""}]"	"[{""id"": ""RHEA:27643"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; full RDF artifact"", ""title"": ""Rhea directed reaction 27643"", ""url"": ""https://www.rhea-db.org/rhea/27643""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-002_6c5568347d05	CHEBI:43474	pathwaymech:consumes	RHEA:27643	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27643		"[{""reference_id"": ""RHEA:27643"", ""source_assertion"": ""RHEA:27643 substrates contain CHEBI:43474 with coefficient 1; the compound is hydrogenphosphate."", ""source_locator"": ""rh:27643 rh:substrates <http://rdf.rhea-db.org/27642_L>; <http://rdf.rhea-db.org/27642_L> rh:contains1 <http://rdf.rhea-db.org/Participant_27642_compound_5518>; <http://rdf.rhea-db.org/Participant_27642_compound_5518> rh:compound <http://rdf.rhea-db.org/Compound_5518>; rh:accession/rh:formula/rh:charge""}]"	"[{""id"": ""RHEA:27643"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; full RDF artifact"", ""title"": ""Rhea directed reaction 27643"", ""url"": ""https://www.rhea-db.org/rhea/27643""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-003_fda5a6e6ec2d	RHEA:27643	pathwaymech:produces	CHEBI:57720	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27643		"[{""reference_id"": ""RHEA:27643"", ""source_assertion"": ""RHEA:27643 products contain CHEBI:57720 with coefficient 1; the compound is alpha-D-ribose 1-phosphate(2-)."", ""source_locator"": ""rh:27643 rh:products <http://rdf.rhea-db.org/27642_R>; <http://rdf.rhea-db.org/27642_R> rh:contains1 <http://rdf.rhea-db.org/Participant_27642_compound_2276>; <http://rdf.rhea-db.org/Participant_27642_compound_2276> rh:compound <http://rdf.rhea-db.org/Compound_2276>; rh:accession/rh:formula/rh:charge""}]"	"[{""id"": ""RHEA:27643"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; full RDF artifact"", ""title"": ""Rhea directed reaction 27643"", ""url"": ""https://www.rhea-db.org/rhea/27643""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-004_408bc9a31a25	RHEA:27643	pathwaymech:produces	CHEBI:16708	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27643		"[{""reference_id"": ""RHEA:27643"", ""source_assertion"": ""RHEA:27643 products contain CHEBI:16708 with coefficient 1; the compound is adenine."", ""source_locator"": ""rh:27643 rh:products <http://rdf.rhea-db.org/27642_R>; <http://rdf.rhea-db.org/27642_R> rh:contains1 <http://rdf.rhea-db.org/Participant_27642_compound_4174>; <http://rdf.rhea-db.org/Participant_27642_compound_4174> rh:compound <http://rdf.rhea-db.org/Compound_4174>; rh:accession/rh:formula/rh:charge""}]"	"[{""id"": ""RHEA:27643"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; full RDF artifact"", ""title"": ""Rhea directed reaction 27643"", ""url"": ""https://www.rhea-db.org/rhea/27643""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-005_eaac99e692fd	RHEA:27643	BFO:0000050	MetaCyc:P121-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ADENPHOSPHOR-RXN|MetaCyc:P121-PWY|RHEA:27643		"[{""reference_id"": ""MetaCyc:P121-PWY"", ""source_assertion"": ""P121-PWY includes ADENPHOSPHOR-RXN and selects native layout direction L2R."", ""source_locator"": ""Pathway[@frameid=\""P121-PWY\""]/reaction-list/Reaction[@frameid=\""ADENPHOSPHOR-RXN\""]; reaction-layout[Reaction/@frameid=\""ADENPHOSPHOR-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:ADENPHOSPHOR-RXN"", ""source_assertion"": ""ADENPHOSPHOR-RXN links to Rhea 27645 bidirectional; native chemical sides and physiological orientation are retained separately."", ""source_locator"": ""Reaction[@frameid=\""ADENPHOSPHOR-RXN\""]/dblink[dblink-db=\""RHEA\""]; left; right; reaction-direction""}, {""reference_id"": ""RHEA:27643"", ""source_assertion"": ""Rhea master 27642 contains directed reaction 27643; the selected left-to-right member supplies the normalized chemical equation."", ""source_locator"": ""rh:27642 rh:directionalReaction rh:27643; rh:27643 rh:substrates/rh:products/rh:equation""}]"	"[{""id"": ""MetaCyc:ADENPHOSPHOR-RXN"", ""source_sha256"": ""57c09f3b3b8955e3a7139292e0c3bd0506d4a467782d15099439c22cff29817b"", ""source_version"": ""MetaCyc 22.5 native XML"", ""title"": ""MetaCyc ADENPHOSPHOR-RXN native full XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADENPHOSPHOR-RXN""}, {""id"": ""MetaCyc:P121-PWY"", ""source_sha256"": ""9c80cd6e3f9fc1b42962fdce4de83a7375b6875ca6849aa49c7f492d7af8fb7f"", ""source_version"": ""MetaCyc 22.5 native XML"", ""title"": ""MetaCyc P121-PWY native full XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:P121-PWY""}, {""id"": ""RHEA:27643"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; full RDF artifact"", ""title"": ""Rhea directed reaction 27643"", ""url"": ""https://www.rhea-db.org/rhea/27643""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-006_a2d285270236	CHEBI:58017	pathwaymech:consumes	RHEA:16611	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16611		"[{""reference_id"": ""RHEA:16611"", ""source_assertion"": ""RHEA:16611 substrates contain CHEBI:58017 with coefficient 1; the compound is 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)."", ""source_locator"": ""rh:16611 rh:substrates <http://rdf.rhea-db.org/16609_R>; <http://rdf.rhea-db.org/16609_R> rh:contains1 <http://rdf.rhea-db.org/Participant_16609_compound_4203>; <http://rdf.rhea-db.org/Participant_16609_compound_4203> rh:compound <http://rdf.rhea-db.org/Compound_4203>; rh:accession/rh:formula/rh:charge""}]"	"[{""id"": ""RHEA:16611"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; full RDF artifact"", ""title"": ""Rhea directed reaction 16611"", ""url"": ""https://www.rhea-db.org/rhea/16611""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-007_3c7046e971f2	CHEBI:16708	pathwaymech:consumes	RHEA:16611	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16611		"[{""reference_id"": ""RHEA:16611"", ""source_assertion"": ""RHEA:16611 substrates contain CHEBI:16708 with coefficient 1; the compound is adenine."", ""source_locator"": ""rh:16611 rh:substrates <http://rdf.rhea-db.org/16609_R>; <http://rdf.rhea-db.org/16609_R> rh:contains1 <http://rdf.rhea-db.org/Participant_16609_compound_4174>; <http://rdf.rhea-db.org/Participant_16609_compound_4174> rh:compound <http://rdf.rhea-db.org/Compound_4174>; rh:accession/rh:formula/rh:charge""}]"	"[{""id"": ""RHEA:16611"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; full RDF artifact"", ""title"": ""Rhea directed reaction 16611"", ""url"": ""https://www.rhea-db.org/rhea/16611""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-008_a529f86e1fbf	RHEA:16611	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16611		"[{""reference_id"": ""RHEA:16611"", ""source_assertion"": ""RHEA:16611 products contain CHEBI:456215 with coefficient 1; the compound is adenosine 5'-monophosphate(2-)."", ""source_locator"": ""rh:16611 rh:products <http://rdf.rhea-db.org/16609_L>; <http://rdf.rhea-db.org/16609_L> rh:contains1 <http://rdf.rhea-db.org/Participant_16609_compound_2590>; <http://rdf.rhea-db.org/Participant_16609_compound_2590> rh:compound <http://rdf.rhea-db.org/Compound_2590>; rh:accession/rh:formula/rh:charge""}]"	"[{""id"": ""RHEA:16611"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; full RDF artifact"", ""title"": ""Rhea directed reaction 16611"", ""url"": ""https://www.rhea-db.org/rhea/16611""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-009_ddc525265b39	RHEA:16611	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16611		"[{""reference_id"": ""RHEA:16611"", ""source_assertion"": ""RHEA:16611 products contain CHEBI:33019 with coefficient 1; the compound is diphosphate(3-)."", ""source_locator"": ""rh:16611 rh:products <http://rdf.rhea-db.org/16609_L>; <http://rdf.rhea-db.org/16609_L> rh:contains1 <http://rdf.rhea-db.org/Participant_16609_compound_2106>; <http://rdf.rhea-db.org/Participant_16609_compound_2106> rh:compound <http://rdf.rhea-db.org/Compound_2106>; rh:accession/rh:formula/rh:charge""}]"	"[{""id"": ""RHEA:16611"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; full RDF artifact"", ""title"": ""Rhea directed reaction 16611"", ""url"": ""https://www.rhea-db.org/rhea/16611""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-010_fd6e0a01232f	RHEA:16611	BFO:0000050	MetaCyc:P121-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ADENPRIBOSYLTRAN-RXN|MetaCyc:P121-PWY|RHEA:16611		"[{""reference_id"": ""MetaCyc:P121-PWY"", ""source_assertion"": ""P121-PWY includes ADENPRIBOSYLTRAN-RXN and selects native layout direction R2L."", ""source_locator"": ""Pathway[@frameid=\""P121-PWY\""]/reaction-list/Reaction[@frameid=\""ADENPRIBOSYLTRAN-RXN\""]; reaction-layout[Reaction/@frameid=\""ADENPRIBOSYLTRAN-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:ADENPRIBOSYLTRAN-RXN"", ""source_assertion"": ""ADENPRIBOSYLTRAN-RXN links to Rhea 16609 master; native chemical sides and physiological orientation are retained separately."", ""source_locator"": ""Reaction[@frameid=\""ADENPRIBOSYLTRAN-RXN\""]/dblink[dblink-db=\""RHEA\""]; left; right; reaction-direction""}, {""reference_id"": ""RHEA:16611"", ""source_assertion"": ""Rhea master 16609 contains directed reaction 16611; the selected right-to-left member supplies the normalized chemical equation."", ""source_locator"": ""rh:16609 rh:directionalReaction rh:16611; rh:16611 rh:substrates/rh:products/rh:equation""}]"	"[{""id"": ""MetaCyc:ADENPRIBOSYLTRAN-RXN"", ""source_sha256"": ""bd78fa689e81837ddcf191d42c79e476ad0133176a9cc3cd66fd0fc0eb5a2fbb"", ""source_version"": ""MetaCyc 22.5 native XML"", ""title"": ""MetaCyc ADENPRIBOSYLTRAN-RXN native full XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADENPRIBOSYLTRAN-RXN""}, {""id"": ""MetaCyc:P121-PWY"", ""source_sha256"": ""9c80cd6e3f9fc1b42962fdce4de83a7375b6875ca6849aa49c7f492d7af8fb7f"", ""source_version"": ""MetaCyc 22.5 native XML"", ""title"": ""MetaCyc P121-PWY native full XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:P121-PWY""}, {""id"": ""RHEA:16611"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; full RDF artifact"", ""title"": ""Rhea directed reaction 16611"", ""url"": ""https://www.rhea-db.org/rhea/16611""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-011_fabb5eebdf32	UniProtKB:P0ABP8	BFO:0000050	MetaCyc:DEOD-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOD-CPLX|MetaCyc:DEOD-MONOMER|PMID:30337572|UniProtKB:P0ABP8		"[{""reference_id"": ""MetaCyc:DEOD-CPLX"", ""source_assertion"": ""Native DEOD-CPLX contains six DEOD-MONOMER subunits."", ""source_locator"": ""Protein[@frameid=\""DEOD-CPLX\""]/component[Protein/@frameid=\""DEOD-MONOMER\""]/coefficient""}, {""reference_id"": ""MetaCyc:DEOD-MONOMER"", ""source_assertion"": ""Native DEOD-MONOMER unification cross-reference identifies UniProt P0ABP8."", ""source_locator"": ""Protein[@frameid=\""DEOD-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}, {""reference_id"": ""UniProtKB:P0ABP8"", ""source_assertion"": ""The reviewed subunit comment describes a homohexamer, organized as a trimer of homodimers, with experimental references."", ""source_locator"": ""comments[commentType=\""SUBUNIT\""].texts""}, {""reference_id"": ""PMID:30337572"", ""source_assertion"": ""The E. coli enzyme is a homohexamer; each dimer contributes residues to its neighboring active site, and the trimer-of-dimers assembly stabilizes catalytically productive conformations."", ""source_locator"": ""PMC6193948 Introduction; Results, concluding mechanistic paragraph; Fig. 4""}]"	"[{""id"": ""MetaCyc:DEOD-CPLX"", ""source_sha256"": ""f362dcc29babaf5d23e730a329a7c436a0944d811a36ad1adb8ee8569e7962e5"", ""source_version"": ""MetaCyc 22.5 native XML"", ""title"": ""MetaCyc DEOD-CPLX native full XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOD-CPLX""}, {""id"": ""MetaCyc:DEOD-MONOMER"", ""source_sha256"": ""99f6dcc78816a3a58aab669c0cdaa9a886a0c854dfa8076cbd9a03aa31766893"", ""source_version"": ""MetaCyc 22.5 native XML"", ""title"": ""MetaCyc DEOD-MONOMER native full XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOD-MONOMER""}, {""id"": ""PMID:30337572"", ""source_sha256"": ""1218e2d0107c64412a92a0e365c4bedfa2011eabc73008e9aa8399f20e5b821d"", ""source_version"": ""2018 primary full text, PMC BioC XML"", ""title"": ""Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC6193948/""}, {""id"": ""UniProtKB:P0ABP8"", ""source_sha256"": ""261a1c1e34fcc0af42d3a3b4a16c27a01ecba13eee2437d3f4d8c51e422eed02"", ""source_version"": ""UniProt release 2026_03; 02-September-2026"", ""title"": ""Purine nucleoside phosphorylase DeoD-type"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABP8.json""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-012_1412d85a343f	MetaCyc:DEOD-CPLX	pathwaymech:catalyzes	RHEA:27643	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOD-CPLX|PMID:30337572|UniProtKB:P0ABP8		"[{""reference_id"": ""MetaCyc:DEOD-CPLX"", ""source_assertion"": ""DEOD-CPLX catalyzes ADENPHOSPHOR-ENZRXN, linked to ADENPHOSPHOR-RXN."", ""source_locator"": ""Protein[@frameid=\""DEOD-CPLX\""]/catalyzes/Enzymatic-Reaction[@frameid=\""ADENPHOSPHOR-ENZRXN\""]/reaction""}, {""reference_id"": ""UniProtKB:P0ABP8"", ""source_assertion"": ""The reviewed catalytic activity assigns adenosine phosphorolysis to RHEA:27642, supported by experimental PubMed evidence; direction here follows P121-PWY."", ""source_locator"": ""comments[commentType=\""CATALYTIC ACTIVITY\""].reaction[reactionCrossReferences/id=\""RHEA:27642\""]""}, {""reference_id"": ""PMID:30337572"", ""source_assertion"": ""Wild-type E. coli purine nucleoside phosphorylase was assayed with natural substrate adenosine and phosphate; mutant and substrate-analogue results are distinguished from the wild-type assay."", ""source_locator"": ""PMC6193948 Results, Catalytic and kinetic properties; Table 1 and Fig. 2""}]"	"[{""id"": ""MetaCyc:DEOD-CPLX"", ""source_sha256"": ""f362dcc29babaf5d23e730a329a7c436a0944d811a36ad1adb8ee8569e7962e5"", ""source_version"": ""MetaCyc 22.5 native XML"", ""title"": ""MetaCyc DEOD-CPLX native full XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOD-CPLX""}, {""id"": ""PMID:30337572"", ""source_sha256"": ""1218e2d0107c64412a92a0e365c4bedfa2011eabc73008e9aa8399f20e5b821d"", ""source_version"": ""2018 primary full text, PMC BioC XML"", ""title"": ""Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC6193948/""}, {""id"": ""UniProtKB:P0ABP8"", ""source_sha256"": ""261a1c1e34fcc0af42d3a3b4a16c27a01ecba13eee2437d3f4d8c51e422eed02"", ""source_version"": ""UniProt release 2026_03; 02-September-2026"", ""title"": ""Purine nucleoside phosphorylase DeoD-type"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABP8.json""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-013_35daeee3b2be	UniProtKB:P69503	BFO:0000050	MetaCyc:ADENPRIBOSYLTRAN-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ADENPRIBOSYLTRAN-CPLX|MetaCyc:ADENPRIBOSYLTRAN-MONOMER|UniProtKB:P69503		"[{""reference_id"": ""MetaCyc:ADENPRIBOSYLTRAN-CPLX"", ""source_assertion"": ""The native E. coli MG1655 Apt complex contains two ADENPRIBOSYLTRAN-MONOMER subunits."", ""source_locator"": ""Protein[@frameid=\""ADENPRIBOSYLTRAN-CPLX\""]/component[Protein/@frameid=\""ADENPRIBOSYLTRAN-MONOMER\""]/coefficient; species/Organism/@frameid""}, {""reference_id"": ""MetaCyc:ADENPRIBOSYLTRAN-MONOMER"", ""source_assertion"": ""The native Apt subunit has UniProt P69503 as a unification cross-reference."", ""source_locator"": ""Protein[@frameid=\""ADENPRIBOSYLTRAN-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}, {""reference_id"": ""UniProtKB:P69503"", ""source_assertion"": ""Reviewed subunit annotation states homodimer; no experimental evidence code is attached to this particular comment."", ""source_locator"": ""comments[commentType=\""SUBUNIT\""].texts""}]"	"[{""id"": ""MetaCyc:ADENPRIBOSYLTRAN-CPLX"", ""source_sha256"": ""701bca05bc04a5cc9563857c5a24bb988dd501fcea490b1b057455a5b7bec557"", ""source_version"": ""MetaCyc 22.5 native XML"", ""title"": ""MetaCyc ADENPRIBOSYLTRAN-CPLX native full XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADENPRIBOSYLTRAN-CPLX""}, {""id"": ""MetaCyc:ADENPRIBOSYLTRAN-MONOMER"", ""source_sha256"": ""ec2c66e510ba13affe101895a5b3ad347e7534d98cd031c3f01d6620a8e1c901"", ""source_version"": ""MetaCyc 22.5 native XML"", ""title"": ""MetaCyc ADENPRIBOSYLTRAN-MONOMER native full XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADENPRIBOSYLTRAN-MONOMER""}, {""id"": ""UniProtKB:P69503"", ""source_sha256"": ""1b76a94fe77706f03fdb9d7c3b38b8b85b4ea3cd7e6e22dff1af46289cad71bf"", ""source_version"": ""UniProt release 2026_03; 02-September-2026"", ""title"": ""Adenine phosphoribosyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P69503.json""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-014_f9c69c80a0a6	MetaCyc:ADENPRIBOSYLTRAN-CPLX	pathwaymech:catalyzes	RHEA:16611	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ADENPRIBOSYLTRAN-CPLX|MetaCyc:ADENPRIBOSYLTRAN-RXN|PMID:21111048|UniProtKB:P69503		"[{""reference_id"": ""MetaCyc:ADENPRIBOSYLTRAN-CPLX"", ""source_assertion"": ""Native Apt complex catalyzes ADENPRIBOSYLTRAN-ENZRXN, which links to ADENPRIBOSYLTRAN-RXN."", ""source_locator"": ""Protein[@frameid=\""ADENPRIBOSYLTRAN-CPLX\""]/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""MetaCyc:ADENPRIBOSYLTRAN-RXN"", ""source_assertion"": ""The native reaction is physiologically right-to-left: adenine plus PRPP forms AMP plus diphosphate."", ""source_locator"": ""Reaction[@frameid=\""ADENPRIBOSYLTRAN-RXN\""]/right; left; reaction-direction""}, {""reference_id"": ""UniProtKB:P69503"", ""source_assertion"": ""Reviewed catalytic activity assigns RHEA:16609 under HAMAP MF_00004 inference; this annotation is not presented as a direct assay."", ""source_locator"": ""comments[commentType=\""CATALYTIC ACTIVITY\""].reaction.reactionCrossReferences; reaction.evidences""}, {""reference_id"": ""PMID:21111048"", ""source_assertion"": ""Recombinant E. coli APRT expressed in BL21(AI) was purified and assayed with adenine and PRPP in a coupled assay. This demonstrates activity of the recombinant construct, not whole-pathway wild-type flux."", ""source_locator"": ""PMC4125576 Methods, expression/purification and APRT assay; Results, Determination of enzyme activities; Fig. 3c; Table 1""}]"	"[{""id"": ""MetaCyc:ADENPRIBOSYLTRAN-CPLX"", ""source_sha256"": ""701bca05bc04a5cc9563857c5a24bb988dd501fcea490b1b057455a5b7bec557"", ""source_version"": ""MetaCyc 22.5 native XML"", ""title"": ""MetaCyc ADENPRIBOSYLTRAN-CPLX native full XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADENPRIBOSYLTRAN-CPLX""}, {""id"": ""MetaCyc:ADENPRIBOSYLTRAN-RXN"", ""source_sha256"": ""bd78fa689e81837ddcf191d42c79e476ad0133176a9cc3cd66fd0fc0eb5a2fbb"", ""source_version"": ""MetaCyc 22.5 native XML"", ""title"": ""MetaCyc ADENPRIBOSYLTRAN-RXN native full XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADENPRIBOSYLTRAN-RXN""}, {""id"": ""PMID:21111048"", ""source_sha256"": ""8bcd1b5acffdea4abae8fcda0326e95d13fdc5de1f7681d46bc353271c19156b"", ""source_version"": ""2011 primary full text, PMC BioC XML"", ""title"": ""Expression, purification and analysis of the activity of enzymes from the pentose phosphate pathway."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC4125576/""}, {""id"": ""UniProtKB:P69503"", ""source_sha256"": ""1b76a94fe77706f03fdb9d7c3b38b8b85b4ea3cd7e6e22dff1af46289cad71bf"", ""source_version"": ""UniProt release 2026_03; 02-September-2026"", ""title"": ""Adenine phosphoribosyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P69503.json""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-015_6ca094d6df77	MetaCyc:ADENPRIBOSYLTRAN-CPLX	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ADENPRIBOSYLTRAN-ENZRXN|PMID:21111048		"[{""reference_id"": ""MetaCyc:ADENPRIBOSYLTRAN-ENZRXN"", ""source_assertion"": ""The native Apt enzymatic reaction lists Mg2+ as cofactor, citing Hochstadt-Ozer and Stadtman 1971; that paper was not independently available in full text here."", ""source_locator"": ""Enzymatic-Reaction[@frameid=\""ADENPRIBOSYLTRAN-ENZRXN\""]/cofactor[Compound/@frameid=\""MG+2\""]""}, {""reference_id"": ""PMID:21111048"", ""source_assertion"": ""The recombinant APRT coupled activity assay included 10 mM MgCl2, 1.5 mM PRPP and 1.5 mM adenine hydrochloride at pH 7.8; the assay does not establish in vivo metal occupancy."", ""source_locator"": ""PMC4125576 Methods, Activity assays/APRT, paragraph beginning \""The spectrophotometric assay\""""}]"	"[{""id"": ""MetaCyc:ADENPRIBOSYLTRAN-ENZRXN"", ""source_sha256"": ""ffe8555991465ae4a0112e168da951a0bd288b3ae2f1dc9ccdeb72c7c1094d4d"", ""source_version"": ""MetaCyc 22.5 native XML"", ""title"": ""MetaCyc ADENPRIBOSYLTRAN-ENZRXN native full XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADENPRIBOSYLTRAN-ENZRXN""}, {""id"": ""PMID:21111048"", ""source_sha256"": ""8bcd1b5acffdea4abae8fcda0326e95d13fdc5de1f7681d46bc353271c19156b"", ""source_version"": ""2011 primary full text, PMC BioC XML"", ""title"": ""Expression, purification and analysis of the activity of enzymes from the pentose phosphate pathway."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC4125576/""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-016_c5efe70e61f8	MetaCyc:ADENPRIBOSYLTRAN-CPLX	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ADENPRIBOSYLTRAN-ENZRXN		"[{""reference_id"": ""MetaCyc:ADENPRIBOSYLTRAN-ENZRXN"", ""source_assertion"": ""The native enzymatic reaction lists Mn2+ as an alternative to Mg2+. This is source annotation, not a claim of simultaneous binding or a separately inspected manganese assay."", ""source_locator"": ""Enzymatic-Reaction[@frameid=\""ADENPRIBOSYLTRAN-ENZRXN\""]/alternative-cofactor[cofactor/Compound/@frameid=\""MG+2\""]/alternate/Compound[@frameid=\""MN+2\""]""}]"	"[{""id"": ""MetaCyc:ADENPRIBOSYLTRAN-ENZRXN"", ""source_sha256"": ""ffe8555991465ae4a0112e168da951a0bd288b3ae2f1dc9ccdeb72c7c1094d4d"", ""source_version"": ""MetaCyc 22.5 native XML"", ""title"": ""MetaCyc ADENPRIBOSYLTRAN-ENZRXN native full XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADENPRIBOSYLTRAN-ENZRXN""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-017_4965dfa3e6b9	UniProtKB:P69503	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:365172|UniProtKB:P69503		"[{""reference_id"": ""UniProtKB:P69503"", ""source_assertion"": ""The reviewed entry locates Apt in the cytoplasm; the location comment has no attached experimental evidence code."", ""source_locator"": ""comments[commentType=\""SUBCELLULAR LOCATION\""].subcellularLocations.location""}, {""reference_id"": ""PMID:365172"", ""source_assertion"": ""The inspected abstract places adenine phosphoribosyltransferase intracellularly and reports no significant association with purified membrane fractions, distinguishing localization from preparation-dependent membrane association."", ""source_locator"": ""Europe PMC resultList.result[id=\""365172\""].abstractText""}]"	"[{""id"": ""PMID:365172"", ""source_sha256"": ""9f90796958cc1a4cd7571e8706d6580d07b5894c81207de48ec6b5fb4ca0cedc"", ""source_version"": ""1978 primary abstract in Europe PMC exact PMID batch; full text not inspected"", ""title"": ""The location of purine phosphoribosyltransferase activities in Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/365172/""}, {""id"": ""UniProtKB:P69503"", ""source_sha256"": ""1b76a94fe77706f03fdb9d7c3b38b8b85b4ea3cd7e6e22dff1af46289cad71bf"", ""source_version"": ""UniProt release 2026_03; 02-September-2026"", ""title"": ""Adenine phosphoribosyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P69503.json""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-018_4a8ce458a949	RHEA:27643	RO:0002413	RHEA:16611	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:P121-PWY|PMID:765747|RHEA:16611|RHEA:27643		"[{""reference_id"": ""MetaCyc:P121-PWY"", ""source_assertion"": ""The native pathway orders ADENPHOSPHOR-RXN before ADENPRIBOSYLTRAN-RXN and shows ADENINE as the connecting native compound."", ""source_locator"": ""Pathway[@frameid=\""P121-PWY\""]/reaction-ordering[Reaction/@frameid=\""ADENPRIBOSYLTRAN-RXN\""]/predecessor-reactions; reaction-layout/right-primaries""}, {""reference_id"": ""RHEA:27643"", ""source_assertion"": ""RHEA:27643 products contain CHEBI:16708 with coefficient 1; the compound is adenine."", ""source_locator"": ""rh:27643 rh:products <http://rdf.rhea-db.org/27642_R>; <http://rdf.rhea-db.org/27642_R> rh:contains1 <http://rdf.rhea-db.org/Participant_27642_compound_4174>; <http://rdf.rhea-db.org/Participant_27642_compound_4174> rh:compound <http://rdf.rhea-db.org/Compound_4174>; rh:accession/rh:formula/rh:charge""}, {""reference_id"": ""RHEA:16611"", ""source_assertion"": ""RHEA:16611 substrates contain CHEBI:16708 with coefficient 1; the compound is adenine."", ""source_locator"": ""rh:16611 rh:substrates <http://rdf.rhea-db.org/16609_R>; <http://rdf.rhea-db.org/16609_R> rh:contains1 <http://rdf.rhea-db.org/Participant_16609_compound_4174>; <http://rdf.rhea-db.org/Participant_16609_compound_4174> rh:compound <http://rdf.rhea-db.org/Compound_4174>; rh:accession/rh:formula/rh:charge""}, {""reference_id"": ""PMID:765747"", ""source_assertion"": ""The E. coli salvage scheme places purine nucleoside phosphorylase between adenosine and adenine and adenine phosphoribosyltransferase between adenine and AMP; experiments use the K-12 derivatives listed in Table 1."", ""source_locator"": ""p. 85, Fig. 1; pp. 86-87, Methods and Table 1""}]"	"[{""id"": ""MetaCyc:P121-PWY"", ""source_sha256"": ""9c80cd6e3f9fc1b42962fdce4de83a7375b6875ca6849aa49c7f492d7af8fb7f"", ""source_version"": ""MetaCyc 22.5 native XML"", ""title"": ""MetaCyc P121-PWY native full XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:P121-PWY""}, {""id"": ""PMID:765747"", ""source_sha256"": ""a94c9a8e77e5d839c8bbf07444e21bfbf187347f085d99d5f89745e0043bca0f"", ""source_version"": ""1975 primary full PDF, 7 pages"", ""title"": ""Location on the chromosome of Escherichia coli of genes governing purine metabolism."", ""url"": ""https://ecosalgenes.frenoy.eu/pdf/370.pdf""}, {""id"": ""RHEA:16611"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; full RDF artifact"", ""title"": ""Rhea directed reaction 16611"", ""url"": ""https://www.rhea-db.org/rhea/16611""}, {""id"": ""RHEA:27643"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; full RDF artifact"", ""title"": ""Rhea directed reaction 27643"", ""url"": ""https://www.rhea-db.org/rhea/27643""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-019_5948f4a88e67	UniProtKB:P69503	BFO:0000050	NCBITaxon:83333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P69503		"[{""reference_id"": ""UniProtKB:P69503"", ""source_assertion"": ""The reviewed entry identifies Escherichia coli strain K12, taxon 83333, with ordered locus b0469."", ""source_locator"": ""organism.taxonId; organism.scientificName; genes.orderedLocusNames""}]"	"[{""id"": ""UniProtKB:P69503"", ""source_sha256"": ""1b76a94fe77706f03fdb9d7c3b38b8b85b4ea3cd7e6e22dff1af46289cad71bf"", ""source_version"": ""UniProt release 2026_03; 02-September-2026"", ""title"": ""Adenine phosphoribosyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P69503.json""}]"	""
pathwaymech:MetaCyc_P121-PWY_adenine-i-edge-020_1b2b32d0890c	UniProtKB:P0ABP8	BFO:0000050	NCBITaxon:83333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ABP8		"[{""reference_id"": ""UniProtKB:P0ABP8"", ""source_assertion"": ""The reviewed entry identifies Escherichia coli strain K12, taxon 83333, with ordered locus b4384."", ""source_locator"": ""organism.taxonId; organism.scientificName; genes.orderedLocusNames""}]"	"[{""id"": ""UniProtKB:P0ABP8"", ""source_sha256"": ""261a1c1e34fcc0af42d3a3b4a16c27a01ecba13eee2437d3f4d8c51e422eed02"", ""source_version"": ""UniProt release 2026_03; 02-September-2026"", ""title"": ""Purine nucleoside phosphorylase DeoD-type"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABP8.json""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-001_c29ad3b07063	CHEBI:57720	pathwaymech:consumes	RHEA:27644	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27644	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:27644"", ""source_assertion"": ""The original directional Rhea reaction places CHEBI:57720 on its substrates side with coefficient 1; its master-relative orientation is right_to_left."", ""source_locator"": ""rhea.rdf.gz; rh:27644 rh:substrates rh:27642_R; rh:27642_R rh:contains1 <http://rdf.rhea-db.org/Participant_27642_compound_2276>; rh:compound <http://rdf.rhea-db.org/Compound_2276> / rh:chebi""}]"	"[{""id"": ""RHEA:27644"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""alpha-D-ribose 1-phosphate + adenine => adenosine + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/27644""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-002_736383fcf665	CHEBI:16708	pathwaymech:consumes	RHEA:27644	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27644	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:27644"", ""source_assertion"": ""The original directional Rhea reaction places CHEBI:16708 on its substrates side with coefficient 1; its master-relative orientation is right_to_left."", ""source_locator"": ""rhea.rdf.gz; rh:27644 rh:substrates rh:27642_R; rh:27642_R rh:contains1 <http://rdf.rhea-db.org/Participant_27642_compound_4174>; rh:compound <http://rdf.rhea-db.org/Compound_4174> / rh:chebi""}]"	"[{""id"": ""RHEA:27644"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""alpha-D-ribose 1-phosphate + adenine => adenosine + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/27644""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-003_2140d5e87e51	RHEA:27644	pathwaymech:produces	CHEBI:16335	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27644	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:27644"", ""source_assertion"": ""The original directional Rhea reaction places CHEBI:16335 on its products side with coefficient 1; its master-relative orientation is right_to_left."", ""source_locator"": ""rhea.rdf.gz; rh:27644 rh:products rh:27642_L; rh:27642_L rh:contains1 <http://rdf.rhea-db.org/Participant_27642_compound_2547>; rh:compound <http://rdf.rhea-db.org/Compound_2547> / rh:chebi""}]"	"[{""id"": ""RHEA:27644"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""alpha-D-ribose 1-phosphate + adenine => adenosine + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/27644""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-004_233da909d7b3	RHEA:27644	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27644	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:27644"", ""source_assertion"": ""The original directional Rhea reaction places CHEBI:43474 on its products side with coefficient 1; its master-relative orientation is right_to_left."", ""source_locator"": ""rhea.rdf.gz; rh:27644 rh:products rh:27642_L; rh:27642_L rh:contains1 <http://rdf.rhea-db.org/Participant_27642_compound_5518>; rh:compound <http://rdf.rhea-db.org/Compound_5518> / rh:chebi""}]"	"[{""id"": ""RHEA:27644"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""alpha-D-ribose 1-phosphate + adenine => adenosine + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/27644""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-005_78f7fab3a004	CHEBI:16335	pathwaymech:consumes	RHEA:24409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24409	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:24409"", ""source_assertion"": ""The original directional Rhea reaction places CHEBI:16335 on its substrates side with coefficient 1; its master-relative orientation is left_to_right."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:substrates rh:24408_L; rh:24408_L rh:contains1 <http://rdf.rhea-db.org/Participant_24408_compound_2547>; rh:compound <http://rdf.rhea-db.org/Compound_2547> / rh:chebi""}]"	"[{""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""adenosine + H2O + H(+) => inosine + NH4(+)"", ""url"": ""https://www.rhea-db.org/rhea/24409""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-006_e718e6ee92db	CHEBI:15377	pathwaymech:consumes	RHEA:24409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24409	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:24409"", ""source_assertion"": ""The original directional Rhea reaction places CHEBI:15377 on its substrates side with coefficient 1; its master-relative orientation is left_to_right."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:substrates rh:24408_L; rh:24408_L rh:contains1 <http://rdf.rhea-db.org/Participant_24408_compound_1283>; rh:compound <http://rdf.rhea-db.org/Compound_1283> / rh:chebi""}]"	"[{""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""adenosine + H2O + H(+) => inosine + NH4(+)"", ""url"": ""https://www.rhea-db.org/rhea/24409""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-007_a0dcda07e640	CHEBI:15378	pathwaymech:consumes	RHEA:24409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24409	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:24409"", ""source_assertion"": ""The original directional Rhea reaction places CHEBI:15378 on its substrates side with coefficient 1; its master-relative orientation is left_to_right."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:substrates rh:24408_L; rh:24408_L rh:contains1 <http://rdf.rhea-db.org/Participant_24408_compound_3249>; rh:compound <http://rdf.rhea-db.org/Compound_3249> / rh:chebi""}]"	"[{""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""adenosine + H2O + H(+) => inosine + NH4(+)"", ""url"": ""https://www.rhea-db.org/rhea/24409""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-008_59e2560fd65e	RHEA:24409	pathwaymech:produces	CHEBI:17596	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24409	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:24409"", ""source_assertion"": ""The original directional Rhea reaction places CHEBI:17596 on its products side with coefficient 1; its master-relative orientation is left_to_right."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:products rh:24408_R; rh:24408_R rh:contains1 <http://rdf.rhea-db.org/Participant_24408_compound_1231>; rh:compound <http://rdf.rhea-db.org/Compound_1231> / rh:chebi""}]"	"[{""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""adenosine + H2O + H(+) => inosine + NH4(+)"", ""url"": ""https://www.rhea-db.org/rhea/24409""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-009_f9423cbf3b7b	RHEA:24409	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24409	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:24409"", ""source_assertion"": ""The original directional Rhea reaction places CHEBI:28938 on its products side with coefficient 1; its master-relative orientation is left_to_right."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:products rh:24408_R; rh:24408_R rh:contains1 <http://rdf.rhea-db.org/Participant_24408_compound_1012>; rh:compound <http://rdf.rhea-db.org/Compound_1012> / rh:chebi""}]"	"[{""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""adenosine + H2O + H(+) => inosine + NH4(+)"", ""url"": ""https://www.rhea-db.org/rhea/24409""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-010_4fd250935c6a	CHEBI:17596	pathwaymech:consumes	RHEA:21141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21141	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:21141"", ""source_assertion"": ""The original directional Rhea reaction places CHEBI:17596 on its substrates side with coefficient 1; its master-relative orientation is left_to_right."", ""source_locator"": ""rhea.rdf.gz; rh:21141 rh:substrates rh:21140_L; rh:21140_L rh:contains1 <http://rdf.rhea-db.org/Participant_21140_compound_1231>; rh:compound <http://rdf.rhea-db.org/Compound_1231> / rh:chebi""}]"	"[{""id"": ""RHEA:21141"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""inosine + ATP => IMP + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/21141""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-011_8b1e1edd7c50	CHEBI:30616	pathwaymech:consumes	RHEA:21141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21141	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:21141"", ""source_assertion"": ""The original directional Rhea reaction places CHEBI:30616 on its substrates side with coefficient 1; its master-relative orientation is left_to_right."", ""source_locator"": ""rhea.rdf.gz; rh:21141 rh:substrates rh:21140_L; rh:21140_L rh:contains1 <http://rdf.rhea-db.org/Participant_21140_compound_6372>; rh:compound <http://rdf.rhea-db.org/Compound_6372> / rh:chebi""}]"	"[{""id"": ""RHEA:21141"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""inosine + ATP => IMP + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/21141""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-012_d048c7b51ac7	RHEA:21141	pathwaymech:produces	CHEBI:58053	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21141	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:21141"", ""source_assertion"": ""The original directional Rhea reaction places CHEBI:58053 on its products side with coefficient 1; its master-relative orientation is left_to_right."", ""source_locator"": ""rhea.rdf.gz; rh:21141 rh:products rh:21140_R; rh:21140_R rh:contains1 <http://rdf.rhea-db.org/Participant_21140_compound_1663>; rh:compound <http://rdf.rhea-db.org/Compound_1663> / rh:chebi""}]"	"[{""id"": ""RHEA:21141"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""inosine + ATP => IMP + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/21141""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-013_633ea7974553	RHEA:21141	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21141	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:21141"", ""source_assertion"": ""The original directional Rhea reaction places CHEBI:456216 on its products side with coefficient 1; its master-relative orientation is left_to_right."", ""source_locator"": ""rhea.rdf.gz; rh:21141 rh:products rh:21140_R; rh:21140_R rh:contains1 <http://rdf.rhea-db.org/Participant_21140_compound_2710>; rh:compound <http://rdf.rhea-db.org/Compound_2710> / rh:chebi""}]"	"[{""id"": ""RHEA:21141"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""inosine + ATP => IMP + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/21141""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-014_bcc41fd8eff0	RHEA:21141	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21141	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:21141"", ""source_assertion"": ""The original directional Rhea reaction places CHEBI:15378 on its products side with coefficient 1; its master-relative orientation is left_to_right."", ""source_locator"": ""rhea.rdf.gz; rh:21141 rh:products rh:21140_R; rh:21140_R rh:contains1 <http://rdf.rhea-db.org/Participant_21140_compound_3249>; rh:compound <http://rdf.rhea-db.org/Compound_3249> / rh:chebi""}]"	"[{""id"": ""RHEA:21141"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""inosine + ATP => IMP + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/21141""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-015_64c5ba807660	PathBank:SMP0002083	BFO:0000051	RHEA:27644	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""The primary Pathway's pathwayComponent explicitly contains Reactions/6047; the complete local biochemical event is represented by its independently grounded directional Rhea chemistry."", ""source_locator"": ""bp:Pathway[@rdf:about='http://identifiers.org/smpdb/SMP0002083']/bp:pathwayComponent[@rdf:resource='#Reactions/6047']; bp:BiochemicalReaction[@rdf:ID='Reactions/6047']""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-016_2556b5698b85	PathBank:SMP0002083	BFO:0000051	RHEA:24409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""The primary Pathway's pathwayComponent explicitly contains Reactions/6049; the complete local biochemical event is represented by its independently grounded directional Rhea chemistry."", ""source_locator"": ""bp:Pathway[@rdf:about='http://identifiers.org/smpdb/SMP0002083']/bp:pathwayComponent[@rdf:resource='#Reactions/6049']; bp:BiochemicalReaction[@rdf:ID='Reactions/6049']""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-017_91f7f996ce7d	PathBank:SMP0002083	BFO:0000051	RHEA:21141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""The primary Pathway's pathwayComponent explicitly contains Reactions/6053; the complete local biochemical event is represented by its independently grounded directional Rhea chemistry."", ""source_locator"": ""bp:Pathway[@rdf:about='http://identifiers.org/smpdb/SMP0002083']/bp:pathwayComponent[@rdf:resource='#Reactions/6053']; bp:BiochemicalReaction[@rdf:ID='Reactions/6053']""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-018_f9cb1ce1e68a	PathBank:SMP0002083	BFO:0000051	PathBank:SMP0002083/Transports/505	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""The native primary Pathway explicitly includes Transport505, separate from its three biochemical reactions."", ""source_locator"": ""bp:Pathway[@rdf:about='http://identifiers.org/smpdb/SMP0002083']/bp:pathwayComponent[@rdf:resource='#Transports/505']""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-019_b9a4ca6a6d1d	PathBank:SMP0002083	BFO:0000051	PathBank:SMP0000809	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083	Native non-elementary downstream interface; whole Aspartate Metabolism is not expanded into this record.	"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""The primary Pathway includes SMP0000809 as a Pathway component; its local SubPathway instance contains only the IMP interface interaction, not a reaction list."", ""source_locator"": ""bp:Pathway[@rdf:about='http://identifiers.org/smpdb/SMP0002083']/bp:pathwayComponent; bp:Pathway[@rdf:about='http://identifiers.org/smpdb/SMP0000809']/bp:pathwayComponent""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-020_6656433e6e4b	PathBank:SMP0002083/Transports/505	RO:0002233	PathBank:SMP0002083/Compound/PW_C040034_Periplasmic_Space	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""Transport505 lists Compound/PW_C040034_Periplasmic_Space on bp:left, with native coefficient 1.0 and LEFT_TO_RIGHT conversionDirection. The exact proton ratio is a source assertion, not a primary coupling measurement."", ""source_locator"": ""bp:Transport[@rdf:ID='Transports/505']/bp:left[@rdf:resource='#Compound/PW_C040034_Periplasmic_Space']; bp:Stoichiometry[@rdf:ID='Compound/PW_C040034_Periplasmic_Space/Stoichiometry/1.0']""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-021_4cb878965abd	PathBank:SMP0002083/Transports/505	RO:0002233	PathBank:SMP0002083/Compound/PW_C000024_Periplasmic_Space	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""Transport505 lists Compound/PW_C000024_Periplasmic_Space on bp:left, with native coefficient 1.0 and LEFT_TO_RIGHT conversionDirection. The exact proton ratio is a source assertion, not a primary coupling measurement."", ""source_locator"": ""bp:Transport[@rdf:ID='Transports/505']/bp:left[@rdf:resource='#Compound/PW_C000024_Periplasmic_Space']; bp:Stoichiometry[@rdf:ID='Compound/PW_C000024_Periplasmic_Space/Stoichiometry/1.0']""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-022_bfc28aea1562	PathBank:SMP0002083/Transports/505	RO:0002234	PathBank:SMP0002083/Compound/PW_C000024_Cytosol	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""Transport505 lists Compound/PW_C000024_Cytosol on bp:right, with native coefficient 1.0 and LEFT_TO_RIGHT conversionDirection. The exact proton ratio is a source assertion, not a primary coupling measurement."", ""source_locator"": ""bp:Transport[@rdf:ID='Transports/505']/bp:right[@rdf:resource='#Compound/PW_C000024_Cytosol']; bp:Stoichiometry[@rdf:ID='Compound/PW_C000024_Cytosol/Stoichiometry/1.0']""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-023_db9fd9699bfa	PathBank:SMP0002083/Transports/505	RO:0002234	PathBank:SMP0002083/Compound/PW_C040034_Cytosol	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""Transport505 lists Compound/PW_C040034_Cytosol on bp:right, with native coefficient 1.0 and LEFT_TO_RIGHT conversionDirection. The exact proton ratio is a source assertion, not a primary coupling measurement."", ""source_locator"": ""bp:Transport[@rdf:ID='Transports/505']/bp:right[@rdf:resource='#Compound/PW_C040034_Cytosol']; bp:Stoichiometry[@rdf:ID='Compound/PW_C040034_Cytosol/Stoichiometry/1.0']""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-024_fb7b75d2af05	PathBank:SMP0002083/Compound/PW_C000024_Periplasmic_Space	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""The native compartment-specific molecule points to #CellularLocation/Periplasmic_Space; its location is preserved separately from the unlocalized Rhea chemical form."", ""source_locator"": ""bp:SmallMolecule[@rdf:ID='Compound/PW_C000024_Periplasmic_Space']/bp:cellularLocation; bp:CellularLocationVocabulary[@rdf:ID='CellularLocation/Periplasmic_Space']""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-025_f1a34e545746	PathBank:SMP0002083/Compound/PW_C040034_Periplasmic_Space	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""The native compartment-specific molecule points to #CellularLocation/Periplasmic_Space; its location is preserved separately from the unlocalized Rhea chemical form."", ""source_locator"": ""bp:SmallMolecule[@rdf:ID='Compound/PW_C040034_Periplasmic_Space']/bp:cellularLocation; bp:CellularLocationVocabulary[@rdf:ID='CellularLocation/Periplasmic_Space']""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-026_224ee87e25a0	PathBank:SMP0002083/Compound/PW_C000024_Cytosol	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""The native compartment-specific molecule points to #CellularLocation/Cytosol; its location is preserved separately from the unlocalized Rhea chemical form."", ""source_locator"": ""bp:SmallMolecule[@rdf:ID='Compound/PW_C000024_Cytosol']/bp:cellularLocation; bp:CellularLocationVocabulary[@rdf:ID='CellularLocation/Cytosol']""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-027_22d9b92a6660	PathBank:SMP0002083/Compound/PW_C040034_Cytosol	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""The native compartment-specific molecule points to #CellularLocation/Cytosol; its location is preserved separately from the unlocalized Rhea chemical form."", ""source_locator"": ""bp:SmallMolecule[@rdf:ID='Compound/PW_C040034_Cytosol']/bp:cellularLocation; bp:CellularLocationVocabulary[@rdf:ID='CellularLocation/Cytosol']""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-028_0ff2603fbcb5	PathBank:SMP0002083/Compound/PW_C000114_Cytosol	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""The native compartment-specific molecule points to #CellularLocation/Cytosol; its location is preserved separately from the unlocalized Rhea chemical form."", ""source_locator"": ""bp:SmallMolecule[@rdf:ID='Compound/PW_C000114_Cytosol']/bp:cellularLocation; bp:CellularLocationVocabulary[@rdf:ID='CellularLocation/Cytosol']""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-029_76e87473107a	PathBank:SMP0002083/Compound/PW_C000114_Cytoplasm	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""The native compartment-specific molecule points to #CellularLocation/Cytoplasm; its location is preserved separately from the unlocalized Rhea chemical form."", ""source_locator"": ""bp:SmallMolecule[@rdf:ID='Compound/PW_C000114_Cytoplasm']/bp:cellularLocation; bp:CellularLocationVocabulary[@rdf:ID='CellularLocation/Cytoplasm']""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-030_3d492025c545	RHEA:27644	RO:0002233	PathBank:SMP0002083/Compound/PW_C000024_Cytosol	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083	Native compartment view of adenine; not an additional stoichiometric substrate.	"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""Native Reactions/6047 uses Compound/PW_C000024_Cytosol (adenine). This is its compartment-specific source view, corresponding to the separately balanced adenine substrate."", ""source_locator"": ""bp:BiochemicalReaction[@rdf:ID='Reactions/6047']/bp:left[@rdf:resource='#Compound/PW_C000024_Cytosol']; bp:SmallMoleculeReference[@rdf:ID='CompoundReference/PW_C000024']/bp:xref""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-031_5badb3c13319	RHEA:21141	RO:0002234	PathBank:SMP0002083/Compound/PW_C000114_Cytosol	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083	Native generic output view; no extra product coefficient or protonation reaction is asserted.	"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""Native Reactions/6053 outputs Compound/PW_C000114_Cytosol, whose reference is neutral inosinic acid CHEBI:17202. This source-view output is distinct from balanced Rhea IMP(2-)."", ""source_locator"": ""bp:BiochemicalReaction[@rdf:ID='Reactions/6053']/bp:right[@rdf:resource='#Compound/PW_C000114_Cytosol']; bp:SmallMoleculeReference[@rdf:ID='CompoundReference/PW_C000114']""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-032_49563ec1c683	PathBank:SMP0000809	RO:0002233	PathBank:SMP0002083/Compound/PW_C000114_Cytoplasm	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083|PathBank:SMP0002083/PWML	Opaque native input interface, without an elementary equation or invented Cytosol-to-Cytoplasm transfer.	"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""The SMP0000809 SubPathway contains Interaction581268 with participant Compound/PW_C000114_Cytoplasm, named SubPathwayInput."", ""source_locator"": ""bp:Pathway[@rdf:about='http://identifiers.org/smpdb/SMP0000809']/bp:pathwayComponent; bp:Interaction[@rdf:ID='SubPathwayInteractions/581268']/bp:participant; bp:SmallMolecule[@rdf:ID='Compound/PW_C000114_Cytoplasm']/bp:name""}, {""reference_id"": ""PathBank:SMP0002083/PWML"", ""source_assertion"": ""Native sub-pathway581268 references pathway551 and declares Compound114 as a sub-pathway-input. Sub-pathway-visualization595297 refers to581268 and contains a compound visualization with side Left."", ""source_locator"": ""Original PWML lines24-38: sub-pathways/sub-pathway[id=581268]/reference-pathway-id=551 and sub-pathway-inputs/sub-pathway-input/element-id=114, element-type=Compound; lines8627-8645: sub-pathway-visualizations/sub-pathway-visualization[id=595297, sub-pathway-id=581268]/sub_pathway_compound_visualizations/sub-pathway-compound-visualization/side=Left""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}, {""id"": ""PathBank:SMP0002083/PWML"", ""source_sha256"": ""4ab166de57f7a201ae2d5eb9fd569da9bd37d2d18c7d4abd0207fafd87e21d53"", ""source_version"": ""Original fetched 2026-10-11; strict XML fails at unbound option prefix line 8275; bounded raw-text interface inspected"", ""title"": ""Current native pathway diagram markup"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=pwml""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-033_673fcfbebcb6	PathBank:SMP0002083/Transports/505	RO:0002413	RHEA:27644	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083|RHEA:27644		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""Transport505 has cytosolic adenine as its output, and Reactions/6047 has the exact same native molecule instance as input."", ""source_locator"": ""bp:Transport[@rdf:ID='Transports/505']/bp:right; bp:BiochemicalReaction[@rdf:ID='Reactions/6047']/bp:left: #Compound/PW_C000024_Cytosol""}, {""reference_id"": ""RHEA:27644"", ""source_assertion"": ""The directional reaction consumes adenine CHEBI:16708."", ""source_locator"": ""rhea.rdf.gz; rh:27644 rh:substrates rh:27642_R; Compound_4174 rh:chebi CHEBI:16708""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}, {""id"": ""RHEA:27644"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""alpha-D-ribose 1-phosphate + adenine => adenosine + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/27644""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-034_f1cf945d7bcb	RHEA:27644	RO:0002413	RHEA:24409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083|RHEA:24409|RHEA:27644		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""Native Reactions/6047 supplies the nucleoside used by Reactions/6049; both reference the same compartment-specific molecule."", ""source_locator"": ""bp:BiochemicalReaction[@rdf:ID='Reactions/6047']/bp:right; bp:BiochemicalReaction[@rdf:ID='Reactions/6049']/bp:left""}, {""reference_id"": ""RHEA:27644"", ""source_assertion"": ""The directional upstream reaction produces CHEBI:16335."", ""source_locator"": ""rhea.rdf.gz; rh:27644 rh:products / rh:contains / rh:compound / rh:chebi CHEBI:16335""}, {""reference_id"": ""RHEA:24409"", ""source_assertion"": ""The directional downstream reaction consumes CHEBI:16335."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:substrates / rh:contains / rh:compound / rh:chebi CHEBI:16335""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}, {""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""adenosine + H2O + H(+) => inosine + NH4(+)"", ""url"": ""https://www.rhea-db.org/rhea/24409""}, {""id"": ""RHEA:27644"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""alpha-D-ribose 1-phosphate + adenine => adenosine + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/27644""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-035_31c74cc2c62c	RHEA:24409	RO:0002413	RHEA:21141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083|RHEA:21141|RHEA:24409		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""Native Reactions/6049 supplies the nucleoside used by Reactions/6053; both reference the same compartment-specific molecule."", ""source_locator"": ""bp:BiochemicalReaction[@rdf:ID='Reactions/6049']/bp:right; bp:BiochemicalReaction[@rdf:ID='Reactions/6053']/bp:left""}, {""reference_id"": ""RHEA:24409"", ""source_assertion"": ""The directional upstream reaction produces CHEBI:17596."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:products / rh:contains / rh:compound / rh:chebi CHEBI:17596""}, {""reference_id"": ""RHEA:21141"", ""source_assertion"": ""The directional downstream reaction consumes CHEBI:17596."", ""source_locator"": ""rhea.rdf.gz; rh:21141 rh:substrates / rh:contains / rh:compound / rh:chebi CHEBI:17596""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}, {""id"": ""RHEA:21141"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""inosine + ATP => IMP + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/21141""}, {""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 / 2026-09-02; retained original rehashed; hash covers complete original gzip"", ""title"": ""adenosine + H2O + H(+) => inosine + NH4(+)"", ""url"": ""https://www.rhea-db.org/rhea/24409""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-036_6513bdc3bc38	MetaCyc:DEOD-CPLX	BFO:0000051	UniProtKB:P0ABP8	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOD-CPLX|PMID:30337572|PathBank:SMP0002083|UniProtKB:P0ABP8	Native 6-copy assembly; has_part does not encode stoichiometry in a separate scalar field.	"[{""reference_id"": ""MetaCyc:DEOD-CPLX"", ""source_assertion"": ""The META27 complex has 6 copies of DEOD-MONOMER; its component identity is independently grounded to P0ABP8."", ""source_locator"": ""/ptools-xml/Protein[@frameid='DEOD-CPLX']/component[Protein/@frameid='DEOD-MONOMER']/coefficient""}, {""reference_id"": ""UniProtKB:P0ABP8"", ""source_assertion"": ""The reviewed record specifies a homohexamer, a trimer of homodimers (ECO:0000269 and HAMAP inference)."", ""source_locator"": ""/primaryAccession; /comments/10""}, {""reference_id"": ""PMID:30337572"", ""source_assertion"": ""The crystallographic structures are homohexamers of six identical 238-residue chains. The current reviewed sequence is 239 residues; processing is not inferred."", ""source_locator"": ""BioC document/passages, passage40 Results assembly; passage63 Methods preparation""}, {""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""The native DeoD complex has six copies of Protein6182; its protein reference contains the UniProt P0ABP8 unification xref."", ""source_locator"": ""bp:Complex[@rdf:ID='ProteinComplex/4056_Cytosol']/bp:componentStoichiometry; bp:ProteinReference[@rdf:ID='ProteinReference/6182']/bp:xref""}]"	"[{""id"": ""MetaCyc:DEOD-CPLX"", ""source_sha256"": ""80d6e6f1039ffdb9a535eeb3b20bce075340c5527fcf30406bcc7fff25a70816"", ""source_version"": ""META PGDB 27.0; acquired 2026-10-11"", ""title"": ""purine nucleoside phosphorylase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:DEOD-CPLX""}, {""id"": ""PMID:30337572"", ""source_sha256"": ""1218e2d0107c64412a92a0e365c4bedfa2011eabc73008e9aa8399f20e5b821d"", ""source_version"": ""Retained complete BioC XML; relevant passages 40-52 and 63 inspected; original hash"", ""title"": ""Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC6193948/""}, {""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}, {""id"": ""UniProtKB:P0ABP8"", ""source_sha256"": ""261a1c1e34fcc0af42d3a3b4a16c27a01ecba13eee2437d3f4d8c51e422eed02"", ""source_version"": ""Reviewed entry 149; sequence 2; annotation 2026-09-02"", ""title"": ""Purine nucleoside phosphorylase DeoD-type"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABP8.json""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-037_f6ae72a6e35c	MetaCyc:CPLX0-322	BFO:0000051	UniProtKB:P0AEW6	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-322|MetaCyc:GSK-MONOMER|PMID:32857952|UniProtKB:P0AEW6	Native 2-copy assembly; has_part does not encode stoichiometry in a separate scalar field.	"[{""reference_id"": ""MetaCyc:CPLX0-322"", ""source_assertion"": ""The META27 complex has 2 copies of GSK-MONOMER; its component identity is independently grounded to P0AEW6."", ""source_locator"": ""/ptools-xml/Protein[@frameid='CPLX0-322']/component[Protein/@frameid='GSK-MONOMER']/coefficient""}, {""reference_id"": ""UniProtKB:P0AEW6"", ""source_assertion"": ""The reviewed record specifies a homodimer (ECO:0000269, PMID10879466)."", ""source_locator"": ""/primaryAccession; /comments/8""}, {""reference_id"": ""PMID:32857952"", ""source_assertion"": ""Gsk is dimeric without ppGpp in SEC-MALS; ppGpp shifts it toward a tetramer in a concentration-dependent manner. Dimer-interface mutants lose activity."", ""source_locator"": ""section#S3; section#S4; figure#F1; figure#F2""}, {""reference_id"": ""MetaCyc:GSK-MONOMER"", ""source_assertion"": ""The native GSK-MONOMER has a UniProt unification link to P0AEW6, bridging the complex subunit to the reviewed protein."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""GSK-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]; /ptools-xml/Protein/component-of""}]"	"[{""id"": ""MetaCyc:CPLX0-322"", ""source_sha256"": ""0017a2bc1d9d212455392b60f542e75c9a897312a2f5f5c1fd6eea0b8d8bfb0c"", ""source_version"": ""META PGDB 27.0; acquired 2026-10-11"", ""title"": ""inosine/guanosine kinase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPLX0-322""}, {""id"": ""MetaCyc:GSK-MONOMER"", ""source_sha256"": ""3ffc581681db632933d22f4ac7f96e19f41bc04a9783fba9e8cc2a9c072e4687"", ""source_version"": ""META PGDB 27.0; original fetched 2026-10-11"", ""title"": ""inosine/guanosine kinase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:GSK-MONOMER""}, {""id"": ""PMID:32857952"", ""source_sha256"": ""d56d5330f10f96ad3c28ecdd10d26c0a7d5a8bf22ec05bb26dae7ef0e95845db"", ""source_version"": ""Relevant primary Results S3-S5, F1-F3 and methods S45/S48 inspected; complete original retained; original hash"", ""title"": ""ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC8362273/""}, {""id"": ""UniProtKB:P0AEW6"", ""source_sha256"": ""b2f56a5134caa015884e5b6571e050c4b2e8f24e0e6b069bb20145a733d091a9"", ""source_version"": ""Reviewed entry 135; sequence 1; annotation 2026-09-02"", ""title"": ""Guanosine-inosine kinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AEW6.json""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-038_3d365b922173	MetaCyc:PC00033	BFO:0000051	UniProtKB:P0ACP7	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PC00033|MetaCyc:PD00219|UniProtKB:P0ACP7	Native 2-copy assembly; has_part does not encode stoichiometry in a separate scalar field.	"[{""reference_id"": ""MetaCyc:PC00033"", ""source_assertion"": ""The META27 complex has 2 copies of PD00219; its component identity is independently grounded to P0ACP7."", ""source_locator"": ""/ptools-xml/Protein[@frameid='PC00033']/component[Protein/@frameid='PD00219']/coefficient""}, {""reference_id"": ""UniProtKB:P0ACP7"", ""source_assertion"": ""The reviewed record specifies a homodimer supported by experimental literature (ECO:0000269)."", ""source_locator"": ""/primaryAccession; /comments/2""}, {""reference_id"": ""MetaCyc:PD00219"", ""source_assertion"": ""Native PurR monomer PD00219 has UniProt unification link P0ACP7 and component-of PC00033."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""PD00219\""]/dblink[dblink-db=\""UNIPROT\""]; /ptools-xml/Protein/component-of""}]"	"[{""id"": ""MetaCyc:PC00033"", ""source_sha256"": ""d784e0accbf4cfb6eedb5065659d7e33d2e25dc18e81d3f98ff8d0b22026e8dc"", ""source_version"": ""META PGDB 27.0; acquired 2026-10-11"", ""title"": ""DNA-binding transcriptional repressor PurR"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PC00033""}, {""id"": ""MetaCyc:PD00219"", ""source_sha256"": ""8f062333f5da667a478cd064078a3d82c6e54a0b55ae7cd01d4b0a8a4abd7752"", ""source_version"": ""META PGDB 27.0; original fetched 2026-10-11"", ""title"": ""DNA-binding transcriptional repressor PurR"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PD00219""}, {""id"": ""UniProtKB:P0ACP7"", ""source_sha256"": ""29ff164a3ab6b1e39aa336d894091a78fa9262a1a0d18dc72066b4bc6e8420ce"", ""source_version"": ""Reviewed entry 145; sequence 2; annotation 2026-09-02"", ""title"": ""HTH-type transcriptional repressor PurR"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ACP7.json""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-039_91b9134e1f1d	MetaCyc:DEOD-CPLX	pathwaymech:catalyzes	RHEA:27644	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083|UniProtKB:P0ABP8		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""ReactionCatalysis6011 controls adenine-to-adenosine Reactions/6047 through Complex4056, which explicitly contains six Protein6182 (P0ABP8) copies."", ""source_locator"": ""bp:Catalysis[@rdf:ID='ReactionCatalysis/6011']; bp:Complex[@rdf:ID='ProteinComplex/4056_Cytosol']; bp:ProteinReference[@rdf:ID='ProteinReference/6182']""}, {""reference_id"": ""UniProtKB:P0ABP8"", ""source_assertion"": ""Reviewed DeoD catalyzes reversible adenosine phosphorolysis; the selected synthesis direction is the native pathway orientation (experimental ECO:0000269)."", ""source_locator"": ""/comments/0; /comments/4; /comments/10""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}, {""id"": ""UniProtKB:P0ABP8"", ""source_sha256"": ""261a1c1e34fcc0af42d3a3b4a16c27a01ecba13eee2437d3f4d8c51e422eed02"", ""source_version"": ""Reviewed entry 149; sequence 2; annotation 2026-09-02"", ""title"": ""Purine nucleoside phosphorylase DeoD-type"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABP8.json""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-040_b54d7e987053	UniProtKB:P22333	pathwaymech:catalyzes	RHEA:24409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083|UniProtKB:P22333		"[{""reference_id"": ""UniProtKB:P22333"", ""source_assertion"": ""The reviewed adenosine deaminase explicitly lists physiological RHEA:24409, converting adenosine to inosine and ammonium; ECO:0000269 and HAMAP ECO:0000255 are preserved."", ""source_locator"": ""/comments/1/physiologicalReactions; /primaryAccession""}, {""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""ReactionCatalysis6013 connects Add Protein6409 to Reactions/6049."", ""source_locator"": ""bp:Catalysis[@rdf:ID='ReactionCatalysis/6013']; bp:ProteinReference[@rdf:ID='ProteinReference/6409']""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}, {""id"": ""UniProtKB:P22333"", ""source_sha256"": ""23e32e2f4a9fc0b04d71ef7ccef5441c01b1b100951453b1f47d623fe4782181"", ""source_version"": ""Reviewed entry 183; sequence 2; annotation 2026-09-02"", ""title"": ""Adenosine deaminase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P22333.json""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-041_3c76376211da	MetaCyc:CPLX0-322	pathwaymech:catalyzes	RHEA:21141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:32857952|PMID:765747|UniProtKB:P0AEW6		"[{""reference_id"": ""UniProtKB:P0AEW6"", ""source_assertion"": ""The reviewed protein lists physiological RHEA:21141 and a homodimer assembly, with experimental ECO:0000269 evidence."", ""source_locator"": ""/comments/2/physiologicalReactions; /comments/8""}, {""reference_id"": ""PMID:32857952"", ""source_assertion"": ""Purified Gsk was assayed with inosine and ATP-Mg; IMP formation was coupled to IMP dehydrogenase and NADH readout. The dimer interface is required for activity."", ""source_locator"": ""section#S3; section#S4; section#S48""}, {""reference_id"": ""PMID:765747"", ""source_assertion"": ""In the specified K-12 mutant comparison, adding the gsk lesion reduced guanosine kinase activity and also lowered measured inosine kinase activity; adenosine kinase activity was unchanged. No complete-route flux is inferred."", ""source_locator"": ""Original seven-page PDF, printed p89 Table4; strain definitions p87 Table1""}]"	"[{""id"": ""PMID:32857952"", ""source_sha256"": ""d56d5330f10f96ad3c28ecdd10d26c0a7d5a8bf22ec05bb26dae7ef0e95845db"", ""source_version"": ""Relevant primary Results S3-S5, F1-F3 and methods S45/S48 inspected; complete original retained; original hash"", ""title"": ""ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC8362273/""}, {""id"": ""PMID:765747"", ""source_sha256"": ""a94c9a8e77e5d839c8bbf07444e21bfbf187347f085d99d5f89745e0043bca0f"", ""source_version"": ""Retained 7-page primary PDF; all pages extracted; pp85,87,89,90 figures/tables visually inspected; original hash"", ""title"": ""Location on the chromosome of Escherichia coli of genes governing purine metabolism. Adenosine deaminase (add), guanosine kinase (gsk) and hypoxanthine phosphoribosyltransferase (hpt)."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/765747/""}, {""id"": ""UniProtKB:P0AEW6"", ""source_sha256"": ""b2f56a5134caa015884e5b6571e050c4b2e8f24e0e6b069bb20145a733d091a9"", ""source_version"": ""Reviewed entry 135; sequence 1; annotation 2026-09-02"", ""title"": ""Guanosine-inosine kinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AEW6.json""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-042_972b680372fd	UniProtKB:P31466	pathwaymech:catalyzes	PathBank:SMP0002083/Transports/505	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:24214977|PMID:6198438|PathBank:SMP0002083		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""TransportCatalysis436 controls Transport505 through Protein7110, whose reference identifies UniProt P31466."", ""source_locator"": ""bp:Catalysis[@rdf:ID='TransportCatalysis/436']; bp:ProteinReference[@rdf:ID='ProteinReference/7110']""}, {""reference_id"": ""PMID:24214977"", ""source_assertion"": ""PurP was directly identified as a high-affinity adenine transporter (Km about 1 micromolar). Constructs came from T184; uptake hosts were specified mutant strains. This does not measure proton stoichiometry."", ""source_locator"": ""section#sec2; section#sec12; section#T1""}, {""reference_id"": ""PMID:6198438"", ""source_assertion"": ""The indexed abstract reports proton-motive-force dependence and metabolic trapping of adenine uptake. Only the abstract was inspected."", ""source_locator"": ""Europe PMC core resultList/result[id=6198438]/abstractText""}]"	"[{""id"": ""PMID:24214977"", ""source_sha256"": ""ae028a3fc27e0e73ad8121742cf8de09226ffae6593135df287aca0c7fbac58b"", ""source_version"": ""Relevant primary introduction, methods, transport results and discussion inspected; complete original retained; original hash"", ""title"": ""Functional Identification of the Hypoxanthine/Guanine Transporters YjcD and YgfQ and the Adenine Transporters PurP and YicO of Escherichia coli K-12"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3873542/""}, {""id"": ""PMID:6198438"", ""source_sha256"": ""ed33f66c8fa4d80c9107527a345b81586b20c61f937e6fede78c64405bd20f94"", ""source_version"": ""Indexed primary abstract only; requested full PDF access failed; original hash"", ""title"": ""Transport of nucleic acid bases into Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/6198438/""}, {""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-043_15899447de8e	UniProtKB:P31466	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31466		"[{""reference_id"": ""UniProtKB:P31466"", ""source_assertion"": ""Reviewed AdeP is a multipass cell-inner-membrane protein (ECO:0000269)."", ""source_locator"": ""/comments/3/subcellularLocations""}]"	"[{""id"": ""UniProtKB:P31466"", ""source_sha256"": ""3c3caa6cb28dff5457051bcff75b2b7a70e225c8eaa2ca52dd9dfdd7fcaf5ee8"", ""source_version"": ""Reviewed entry 161; sequence 2; annotation 2026-01-28"", ""title"": ""Adenine permease AdeP"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31466.json""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-044_78119e3ab70a	UniProtKB:P22333	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P22333		"[{""reference_id"": ""UniProtKB:P22333"", ""source_assertion"": ""One Zn(2+) per Add subunit is annotated from HAMAP MF_00540 with ECO:0000255; this is an inference, not a directly inspected metal-occupancy experiment."", ""source_locator"": ""/comments/3/cofactors; /comments/3/note""}]"	"[{""id"": ""UniProtKB:P22333"", ""source_sha256"": ""23e32e2f4a9fc0b04d71ef7ccef5441c01b1b100951453b1f47d623fe4782181"", ""source_version"": ""Reviewed entry 183; sequence 2; annotation 2026-09-02"", ""title"": ""Adenosine deaminase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P22333.json""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-045_d15e5ede75a7	MetaCyc:CPLX0-322	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:32857952|UniProtKB:P0AEW6		"[{""reference_id"": ""UniProtKB:P0AEW6"", ""source_assertion"": ""Mg(2+) is the annotated cofactor. Free Mg(2+) in addition to Mg-ATP is described as probable; experimental ECO:0000269 and HAMAP ECO:0000255 are retained."", ""source_locator"": ""/comments/3""}, {""reference_id"": ""PMID:32857952"", ""source_assertion"": ""The inosine kinase assay used 5 mM ATP-Mg and 5 mM MgCl2; these are measured assay conditions, not resolved microscopic occupancy."", ""source_locator"": ""section#S48""}]"	"[{""id"": ""PMID:32857952"", ""source_sha256"": ""d56d5330f10f96ad3c28ecdd10d26c0a7d5a8bf22ec05bb26dae7ef0e95845db"", ""source_version"": ""Relevant primary Results S3-S5, F1-F3 and methods S45/S48 inspected; complete original retained; original hash"", ""title"": ""ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC8362273/""}, {""id"": ""UniProtKB:P0AEW6"", ""source_sha256"": ""b2f56a5134caa015884e5b6571e050c4b2e8f24e0e6b069bb20145a733d091a9"", ""source_version"": ""Reviewed entry 135; sequence 1; annotation 2026-09-02"", ""title"": ""Guanosine-inosine kinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AEW6.json""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-046_45c6b1e73bbb	CHEBI:58189	pathwaymech:inhibits	UniProtKB:P0AEW6	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:32857952	Condition-dependent Gsk population; this edge does not assert an isolated monomer or an obligate tetramer.	"[{""reference_id"": ""PMID:32857952"", ""source_assertion"": ""GDP binds and inhibits Gsk; ligands shift the dimer/tetramer equilibrium. ppGpp-bound tetramers are less active than ppGpp-bound dimers. Charged ChEBI forms identify the ligand, not measured assay protonation."", ""source_locator"": ""section#S3; section#S5; figure#F1; figure#F3""}]"	"[{""id"": ""PMID:32857952"", ""source_sha256"": ""d56d5330f10f96ad3c28ecdd10d26c0a7d5a8bf22ec05bb26dae7ef0e95845db"", ""source_version"": ""Relevant primary Results S3-S5, F1-F3 and methods S45/S48 inspected; complete original retained; original hash"", ""title"": ""ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC8362273/""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-047_adf742b8dbd7	CHEBI:77828	pathwaymech:inhibits	UniProtKB:P0AEW6	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:32857952	Condition-dependent Gsk population; this edge does not assert an isolated monomer or an obligate tetramer.	"[{""reference_id"": ""PMID:32857952"", ""source_assertion"": ""ppGpp binds and inhibits Gsk; ligands shift the dimer/tetramer equilibrium. ppGpp-bound tetramers are less active than ppGpp-bound dimers. Charged ChEBI forms identify the ligand, not measured assay protonation."", ""source_locator"": ""section#S3; section#S5; figure#F1; figure#F3""}]"	"[{""id"": ""PMID:32857952"", ""source_sha256"": ""d56d5330f10f96ad3c28ecdd10d26c0a7d5a8bf22ec05bb26dae7ef0e95845db"", ""source_version"": ""Relevant primary Results S3-S5, F1-F3 and methods S45/S48 inspected; complete original retained; original hash"", ""title"": ""ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC8362273/""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-048_a152ca7e7530	CHEBI:29103	pathwaymech:activates	UniProtKB:P0AEW6	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AEW6	Database-reported assay regulation; no physiological ion concentration or cofactor role is inferred.	"[{""reference_id"": ""UniProtKB:P0AEW6"", ""source_assertion"": ""K(+) stimulates kinase activity in the reviewed activity-regulation comment (ECO:0000269, PMID7665468). The cited original was accessible only as an abstract; quantitative conditions are not asserted."", ""source_locator"": ""/comments/4""}]"	"[{""id"": ""UniProtKB:P0AEW6"", ""source_sha256"": ""b2f56a5134caa015884e5b6571e050c4b2e8f24e0e6b069bb20145a733d091a9"", ""source_version"": ""Reviewed entry 135; sequence 1; annotation 2026-09-02"", ""title"": ""Guanosine-inosine kinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AEW6.json""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-049_7f53fbd73fb6	CHEBI:29036	pathwaymech:inhibits	UniProtKB:P0AEW6	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AEW6	Database-reported assay regulation; no physiological ion concentration or cofactor role is inferred.	"[{""reference_id"": ""UniProtKB:P0AEW6"", ""source_assertion"": ""Cu(2+) inhibits both guanosine and inosine kinase activities in the reviewed activity-regulation comment (ECO:0000269, PMID7665468). The cited original was accessible only as an abstract; quantitative conditions are not asserted."", ""source_locator"": ""/comments/4""}]"	"[{""id"": ""UniProtKB:P0AEW6"", ""source_sha256"": ""b2f56a5134caa015884e5b6571e050c4b2e8f24e0e6b069bb20145a733d091a9"", ""source_version"": ""Reviewed entry 135; sequence 1; annotation 2026-09-02"", ""title"": ""Guanosine-inosine kinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AEW6.json""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-050_40d798365ce9	CHEBI:29105	pathwaymech:inhibits	UniProtKB:P0AEW6	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AEW6	Database-reported assay regulation; no physiological ion concentration or cofactor role is inferred.	"[{""reference_id"": ""UniProtKB:P0AEW6"", ""source_assertion"": ""Zn(2+) inhibits both guanosine and inosine kinase activities in the reviewed activity-regulation comment (ECO:0000269, PMID7665468). The cited original was accessible only as an abstract; quantitative conditions are not asserted."", ""source_locator"": ""/comments/4""}]"	"[{""id"": ""UniProtKB:P0AEW6"", ""source_sha256"": ""b2f56a5134caa015884e5b6571e050c4b2e8f24e0e6b069bb20145a733d091a9"", ""source_version"": ""Reviewed entry 135; sequence 1; annotation 2026-09-02"", ""title"": ""Guanosine-inosine kinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AEW6.json""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-051_e141e65ceab8	CHEBI:17368	pathwaymech:activates	MetaCyc:PC00033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ACP7	Activation of repressor DNA binding, which enables transcriptional repression.	"[{""reference_id"": ""UniProtKB:P0ACP7"", ""source_assertion"": ""hypoxanthine is an alternative purine corepressor that allosterically activates homodimeric PurR DNA binding (ECO:0000269). Hypoxanthine and guanine are alternatives, not both obligatorily present."", ""source_locator"": ""/comments/0; /comments/2""}]"	"[{""id"": ""UniProtKB:P0ACP7"", ""source_sha256"": ""29ff164a3ab6b1e39aa336d894091a78fa9262a1a0d18dc72066b4bc6e8420ce"", ""source_version"": ""Reviewed entry 145; sequence 2; annotation 2026-09-02"", ""title"": ""HTH-type transcriptional repressor PurR"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ACP7.json""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-052_6a891c264f04	CHEBI:16235	pathwaymech:activates	MetaCyc:PC00033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ACP7	Activation of repressor DNA binding, which enables transcriptional repression.	"[{""reference_id"": ""UniProtKB:P0ACP7"", ""source_assertion"": ""guanine is an alternative purine corepressor that allosterically activates homodimeric PurR DNA binding (ECO:0000269). Hypoxanthine and guanine are alternatives, not both obligatorily present."", ""source_locator"": ""/comments/0; /comments/2""}]"	"[{""id"": ""UniProtKB:P0ACP7"", ""source_sha256"": ""29ff164a3ab6b1e39aa336d894091a78fa9262a1a0d18dc72066b4bc6e8420ce"", ""source_version"": ""Reviewed entry 145; sequence 2; annotation 2026-09-02"", ""title"": ""HTH-type transcriptional repressor PurR"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ACP7.json""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-053_4e247c8dd813	MetaCyc:PC00033	pathwaymech:inhibits	Entrez:948224	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Entrez:948224|PMID:21572102|UniProtKB:P31466	PurR represses adeP/yieG gene expression; no encoding edge is fabricated in the current predicate vocabulary.	"[{""reference_id"": ""PMID:21572102"", ""source_assertion"": ""Combined ChIP-chip and transcription analysis identifies yieG among directly PurR-repressed genes in MG1655. Direct repression is assigned to adeP transcription, not transport-protein catalytic activity."", ""source_locator"": ""section#sec12""}, {""reference_id"": ""UniProtKB:P31466"", ""source_assertion"": ""The reviewed AdeP protein lists adeP, purP and yieG as gene names/synonyms, grounding the primary paper gene name."", ""source_locator"": ""/genes/0""}, {""reference_id"": ""Entrez:948224"", ""source_assertion"": ""NCBI Gene948224 is adeP, locus b3714, MG1655 taxon511145, with Swiss-Prot P31466 cross-reference."", ""source_locator"": ""/Entrezgene-Set/Entrezgene/Entrezgene_gene/Gene-ref; //Dbtag[Dbtag_db=\""UniProtKB/Swiss-Prot\""]; //Org-ref_db/Dbtag[Dbtag_db=\""taxon\""]""}]"	"[{""id"": ""Entrez:948224"", ""source_sha256"": ""e1238369684239710e2417e5b7a0923a9eaa0504d15c27059274a255f4848317"", ""source_version"": ""NCBI Gene original fetched 2026-10-11; update 2026-09-03"", ""title"": ""adeP"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=gene&id=948224&rettype=xml""}, {""id"": ""PMID:21572102"", ""source_sha256"": ""6894d332e33b1779d56624171bb0c65fa765c512f806b4e1580d97b51378a1aa"", ""source_version"": ""Relevant primary Results sec9-sec13 and Discussion sec14 inspected; complete original retained; original hash"", ""title"": ""The PurR regulon in Escherichia coli K-12 MG1655"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3159470/""}, {""id"": ""UniProtKB:P31466"", ""source_sha256"": ""3c3caa6cb28dff5457051bcff75b2b7a70e225c8eaa2ca52dd9dfdd7fcaf5ee8"", ""source_version"": ""Reviewed entry 161; sequence 2; annotation 2026-01-28"", ""title"": ""Adenine permease AdeP"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31466.json""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-054_05e619bf5f70	CHEBI:16708	pathwaymech:activates	Entrez:945851	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Entrez:945851|PMID:21572102	Adenine-induced add transcription under the measured culture conditions; no direct Add enzyme activation is asserted.	"[{""reference_id"": ""PMID:21572102"", ""source_assertion"": ""Adenine supplementation increased add transcript abundance 17.61-fold in the measured MG1655 comparison. The study explicitly finds add not directly regulated by PurR; this is an expression response, not direct ligand binding."", ""source_locator"": ""section#sec9; section#sec13""}, {""reference_id"": ""Entrez:945851"", ""source_assertion"": ""NCBI Gene945851 is add, locus b1623, MG1655 taxon511145, with Swiss-Prot P22333 cross-reference."", ""source_locator"": ""/Entrezgene-Set/Entrezgene/Entrezgene_gene/Gene-ref; //Dbtag[Dbtag_db=\""UniProtKB/Swiss-Prot\""]; //Org-ref_db/Dbtag[Dbtag_db=\""taxon\""]""}]"	"[{""id"": ""Entrez:945851"", ""source_sha256"": ""9743f5cf40e9bada0c584472b0b7000174a5918e39c184d37bd03be2693e0757"", ""source_version"": ""NCBI Gene original fetched 2026-10-11; update 2026-09-03"", ""title"": ""add"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=gene&id=945851&rettype=xml""}, {""id"": ""PMID:21572102"", ""source_sha256"": ""6894d332e33b1779d56624171bb0c65fa765c512f806b4e1580d97b51378a1aa"", ""source_version"": ""Relevant primary Results sec9-sec13 and Discussion sec14 inspected; complete original retained; original hash"", ""title"": ""The PurR regulon in Escherichia coli K-12 MG1655"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3159470/""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-055_d3ca4c87e72b	UniProtKB:P0ABP8	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""Native Protein/6182_Cytosol has cellularLocation Cytosol; its entityReference identifies P0ABP8."", ""source_locator"": ""bp:Protein[@rdf:ID='Protein/6182_Cytosol']/bp:cellularLocation; bp:Protein[@rdf:ID='Protein/6182_Cytosol']/bp:entityReference""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-056_a66a6c9ca8c7	UniProtKB:P22333	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""Native Protein/6409_Cytosol has cellularLocation Cytosol; its entityReference identifies P22333."", ""source_locator"": ""bp:Protein[@rdf:ID='Protein/6409_Cytosol']/bp:cellularLocation; bp:Protein[@rdf:ID='Protein/6409_Cytosol']/bp:entityReference""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:PathBank_SMP0002083_aas2-057_c3364bc76c67	UniProtKB:P0AEW6	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002083		"[{""reference_id"": ""PathBank:SMP0002083"", ""source_assertion"": ""Native Protein/6254_Cytosol has cellularLocation Cytosol; its entityReference identifies P0AEW6."", ""source_locator"": ""bp:Protein[@rdf:ID='Protein/6254_Cytosol']/bp:cellularLocation; bp:Protein[@rdf:ID='Protein/6254_Cytosol']/bp:entityReference""}]"	"[{""id"": ""PathBank:SMP0002083"", ""source_sha256"": ""fc1ce4f334bc0f7a5fe7311bcb823e4dee14ea145ed1082c56c1a2b55e12f552"", ""source_version"": ""Current original acquired 2026-10-11; source page updated 2026-08-11 (not a global release)"", ""title"": ""Adenine and Adenosine Salvage II"", ""url"": ""https://pathbank.org/view/SMP0002083/download?type=owl_markup""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-001_9c690051ad05	CHEBI:57720	pathwaymech:consumes	RHEA:27644	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27644		"[{""reference_id"": ""RHEA:27644"", ""source_assertion"": ""RHEA:27644 explicitly lists CHEBI:57720 as a substrate with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:27644 rh:substrates <http://rdf.rhea-db.org/27642_R>; <http://rdf.rhea-db.org/27642_R> rh:contains1 <http://rdf.rhea-db.org/Participant_27642_compound_2276>; <http://rdf.rhea-db.org/Participant_27642_compound_2276> rh:compound <http://rdf.rhea-db.org/Compound_2276> / rh:chebi""}]"	"[{""id"": ""RHEA:27644"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 27644"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-002_6ebeefbb8a3f	CHEBI:16708	pathwaymech:consumes	RHEA:27644	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27644		"[{""reference_id"": ""RHEA:27644"", ""source_assertion"": ""RHEA:27644 explicitly lists CHEBI:16708 as a substrate with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:27644 rh:substrates <http://rdf.rhea-db.org/27642_R>; <http://rdf.rhea-db.org/27642_R> rh:contains1 <http://rdf.rhea-db.org/Participant_27642_compound_4174>; <http://rdf.rhea-db.org/Participant_27642_compound_4174> rh:compound <http://rdf.rhea-db.org/Compound_4174> / rh:chebi""}]"	"[{""id"": ""RHEA:27644"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 27644"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-003_f3f5014cf037	RHEA:27644	pathwaymech:produces	CHEBI:16335	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27644		"[{""reference_id"": ""RHEA:27644"", ""source_assertion"": ""RHEA:27644 explicitly lists CHEBI:16335 as a product with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:27644 rh:products <http://rdf.rhea-db.org/27642_L>; <http://rdf.rhea-db.org/27642_L> rh:contains1 <http://rdf.rhea-db.org/Participant_27642_compound_2547>; <http://rdf.rhea-db.org/Participant_27642_compound_2547> rh:compound <http://rdf.rhea-db.org/Compound_2547> / rh:chebi""}]"	"[{""id"": ""RHEA:27644"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 27644"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-004_5b9183e176da	RHEA:27644	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27644		"[{""reference_id"": ""RHEA:27644"", ""source_assertion"": ""RHEA:27644 explicitly lists CHEBI:43474 as a product with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:27644 rh:products <http://rdf.rhea-db.org/27642_L>; <http://rdf.rhea-db.org/27642_L> rh:contains1 <http://rdf.rhea-db.org/Participant_27642_compound_5518>; <http://rdf.rhea-db.org/Participant_27642_compound_5518> rh:compound <http://rdf.rhea-db.org/Compound_5518> / rh:chebi""}]"	"[{""id"": ""RHEA:27644"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 27644"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-005_62a4bef6c1c3	CHEBI:16335	pathwaymech:consumes	RHEA:24409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24409		"[{""reference_id"": ""RHEA:24409"", ""source_assertion"": ""RHEA:24409 explicitly lists CHEBI:16335 as a substrate with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:substrates <http://rdf.rhea-db.org/24408_L>; <http://rdf.rhea-db.org/24408_L> rh:contains1 <http://rdf.rhea-db.org/Participant_24408_compound_2547>; <http://rdf.rhea-db.org/Participant_24408_compound_2547> rh:compound <http://rdf.rhea-db.org/Compound_2547> / rh:chebi""}]"	"[{""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 24409"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-006_347f78e72188	CHEBI:15377	pathwaymech:consumes	RHEA:24409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24409		"[{""reference_id"": ""RHEA:24409"", ""source_assertion"": ""RHEA:24409 explicitly lists CHEBI:15377 as a substrate with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:substrates <http://rdf.rhea-db.org/24408_L>; <http://rdf.rhea-db.org/24408_L> rh:contains1 <http://rdf.rhea-db.org/Participant_24408_compound_1283>; <http://rdf.rhea-db.org/Participant_24408_compound_1283> rh:compound <http://rdf.rhea-db.org/Compound_1283> / rh:chebi""}]"	"[{""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 24409"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-007_893013466d1b	CHEBI:15378	pathwaymech:consumes	RHEA:24409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24409		"[{""reference_id"": ""RHEA:24409"", ""source_assertion"": ""RHEA:24409 explicitly lists CHEBI:15378 as a substrate with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:substrates <http://rdf.rhea-db.org/24408_L>; <http://rdf.rhea-db.org/24408_L> rh:contains1 <http://rdf.rhea-db.org/Participant_24408_compound_3249>; <http://rdf.rhea-db.org/Participant_24408_compound_3249> rh:compound <http://rdf.rhea-db.org/Compound_3249> / rh:chebi""}]"	"[{""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 24409"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-008_aa9ce9959219	RHEA:24409	pathwaymech:produces	CHEBI:17596	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24409		"[{""reference_id"": ""RHEA:24409"", ""source_assertion"": ""RHEA:24409 explicitly lists CHEBI:17596 as a product with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:products <http://rdf.rhea-db.org/24408_R>; <http://rdf.rhea-db.org/24408_R> rh:contains1 <http://rdf.rhea-db.org/Participant_24408_compound_1231>; <http://rdf.rhea-db.org/Participant_24408_compound_1231> rh:compound <http://rdf.rhea-db.org/Compound_1231> / rh:chebi""}]"	"[{""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 24409"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-009_a58868775e92	RHEA:24409	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24409		"[{""reference_id"": ""RHEA:24409"", ""source_assertion"": ""RHEA:24409 explicitly lists CHEBI:28938 as a product with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:products <http://rdf.rhea-db.org/24408_R>; <http://rdf.rhea-db.org/24408_R> rh:contains1 <http://rdf.rhea-db.org/Participant_24408_compound_1012>; <http://rdf.rhea-db.org/Participant_24408_compound_1012> rh:compound <http://rdf.rhea-db.org/Compound_1012> / rh:chebi""}]"	"[{""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 24409"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-010_a740f8f43974	CHEBI:17596	pathwaymech:consumes	RHEA:27647	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27647		"[{""reference_id"": ""RHEA:27647"", ""source_assertion"": ""RHEA:27647 explicitly lists CHEBI:17596 as a substrate with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:27647 rh:substrates <http://rdf.rhea-db.org/27646_L>; <http://rdf.rhea-db.org/27646_L> rh:contains1 <http://rdf.rhea-db.org/Participant_27646_compound_1231>; <http://rdf.rhea-db.org/Participant_27646_compound_1231> rh:compound <http://rdf.rhea-db.org/Compound_1231> / rh:chebi""}]"	"[{""id"": ""RHEA:27647"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 27647"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-011_5c4b82e9f5ae	CHEBI:43474	pathwaymech:consumes	RHEA:27647	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27647		"[{""reference_id"": ""RHEA:27647"", ""source_assertion"": ""RHEA:27647 explicitly lists CHEBI:43474 as a substrate with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:27647 rh:substrates <http://rdf.rhea-db.org/27646_L>; <http://rdf.rhea-db.org/27646_L> rh:contains1 <http://rdf.rhea-db.org/Participant_27646_compound_5518>; <http://rdf.rhea-db.org/Participant_27646_compound_5518> rh:compound <http://rdf.rhea-db.org/Compound_5518> / rh:chebi""}]"	"[{""id"": ""RHEA:27647"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 27647"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-012_ebb5b18828af	RHEA:27647	pathwaymech:produces	CHEBI:57720	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27647		"[{""reference_id"": ""RHEA:27647"", ""source_assertion"": ""RHEA:27647 explicitly lists CHEBI:57720 as a product with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:27647 rh:products <http://rdf.rhea-db.org/27646_R>; <http://rdf.rhea-db.org/27646_R> rh:contains1 <http://rdf.rhea-db.org/Participant_27646_compound_2276>; <http://rdf.rhea-db.org/Participant_27646_compound_2276> rh:compound <http://rdf.rhea-db.org/Compound_2276> / rh:chebi""}]"	"[{""id"": ""RHEA:27647"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 27647"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-013_8a7413d98a0e	RHEA:27647	pathwaymech:produces	CHEBI:17368	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27647		"[{""reference_id"": ""RHEA:27647"", ""source_assertion"": ""RHEA:27647 explicitly lists CHEBI:17368 as a product with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:27647 rh:products <http://rdf.rhea-db.org/27646_R>; <http://rdf.rhea-db.org/27646_R> rh:contains1 <http://rdf.rhea-db.org/Participant_27646_compound_3881>; <http://rdf.rhea-db.org/Participant_27646_compound_3881> rh:compound <http://rdf.rhea-db.org/Compound_3881> / rh:chebi""}]"	"[{""id"": ""RHEA:27647"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 27647"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-014_09da3eedfd80	CHEBI:17368	pathwaymech:consumes	RHEA:17975	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17975		"[{""reference_id"": ""RHEA:17975"", ""source_assertion"": ""RHEA:17975 explicitly lists CHEBI:17368 as a substrate with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:17975 rh:substrates <http://rdf.rhea-db.org/17973_R>; <http://rdf.rhea-db.org/17973_R> rh:contains1 <http://rdf.rhea-db.org/Participant_17973_compound_3881>; <http://rdf.rhea-db.org/Participant_17973_compound_3881> rh:compound <http://rdf.rhea-db.org/Compound_3881> / rh:chebi""}]"	"[{""id"": ""RHEA:17975"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 17975"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-015_2f2b6e2906e2	CHEBI:58017	pathwaymech:consumes	RHEA:17975	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17975		"[{""reference_id"": ""RHEA:17975"", ""source_assertion"": ""RHEA:17975 explicitly lists CHEBI:58017 as a substrate with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:17975 rh:substrates <http://rdf.rhea-db.org/17973_R>; <http://rdf.rhea-db.org/17973_R> rh:contains1 <http://rdf.rhea-db.org/Participant_17973_compound_4203>; <http://rdf.rhea-db.org/Participant_17973_compound_4203> rh:compound <http://rdf.rhea-db.org/Compound_4203> / rh:chebi""}]"	"[{""id"": ""RHEA:17975"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 17975"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-016_62d108d948eb	RHEA:17975	pathwaymech:produces	CHEBI:58053	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17975		"[{""reference_id"": ""RHEA:17975"", ""source_assertion"": ""RHEA:17975 explicitly lists CHEBI:58053 as a product with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:17975 rh:products <http://rdf.rhea-db.org/17973_L>; <http://rdf.rhea-db.org/17973_L> rh:contains1 <http://rdf.rhea-db.org/Participant_17973_compound_1663>; <http://rdf.rhea-db.org/Participant_17973_compound_1663> rh:compound <http://rdf.rhea-db.org/Compound_1663> / rh:chebi""}]"	"[{""id"": ""RHEA:17975"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 17975"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-017_924c25d02888	RHEA:17975	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17975		"[{""reference_id"": ""RHEA:17975"", ""source_assertion"": ""RHEA:17975 explicitly lists CHEBI:33019 as a product with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:17975 rh:products <http://rdf.rhea-db.org/17973_L>; <http://rdf.rhea-db.org/17973_L> rh:contains1 <http://rdf.rhea-db.org/Participant_17973_compound_2106>; <http://rdf.rhea-db.org/Participant_17973_compound_2106> rh:compound <http://rdf.rhea-db.org/Compound_2106> / rh:chebi""}]"	"[{""id"": ""RHEA:17975"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 17975"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-018_961ed77dc254	MetaCyc:DEOD-CPLX	pathwaymech:catalyzes	RHEA:27644	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ADENPHOSPHOR-ENZRXN|MetaCyc:PWY-6609|UniProtKB:P0ABP8	DeoD catalyzes both phosphorylase steps. The first is run in the nucleoside-synthetic direction and the third in the phosphorolytic direction; no monomer sufficiency or universal net flux is implied.	"[{""reference_id"": ""UniProtKB:P0ABP8"", ""source_assertion"": ""Reviewed DeoD catalytic-activity comment 4 assigns the matching Rhea reaction family with experimental PMID:235429 attribution. Comment 10 identifies a homohexamer; the enzyme catalyzes reversible phosphorolysis."", ""source_locator"": ""comments[4].reaction; comments[4].reaction.evidences; comments[0]; comments[10]""}, {""reference_id"": ""MetaCyc:ADENPHOSPHOR-ENZRXN"", ""source_assertion"": ""The native enzyme-reaction object connects DEOD-CPLX to this reaction and preserves its reversible catalytic scope. The pathway selects the salvage orientation."", ""source_locator"": ""Enzymatic-Reaction[@frameid=\""ADENPHOSPHOR-ENZRXN\""]/enzyme; reaction; reaction-direction""}, {""reference_id"": ""MetaCyc:PWY-6609"", ""source_assertion"": ""The four-step pathway selects adenine-to-adenosine synthesis for ADENPHOSPHOR-RXN and inosine-to-hypoxanthine cleavage for INOPHOSPHOR-RXN."", ""source_locator"": ""Pathway[@frameid=\""PWY-6609\""]/reaction-layout""}]"	"[{""id"": ""MetaCyc:ADENPHOSPHOR-ENZRXN"", ""source_sha256"": ""07901339a7b9522057ad8b1a39a6585e0f5c9a2089aeebd6d1d75d4df6e65e74"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native ADENPHOSPHOR-ENZRXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADENPHOSPHOR-ENZRXN""}, {""id"": ""MetaCyc:PWY-6609"", ""source_sha256"": ""28fbf114b78001e473764dfecdf5f85204819cf318ea458f51539983f998689a"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native PWY-6609"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6609""}, {""id"": ""UniProtKB:P0ABP8"", ""source_sha256"": ""261a1c1e34fcc0af42d3a3b4a16c27a01ecba13eee2437d3f4d8c51e422eed02"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0ABP8"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABP8.json""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-019_44b1164518dc	MetaCyc:DEOD-CPLX	pathwaymech:catalyzes	RHEA:27647	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:INOPHOSPHOR-ENZRXN|MetaCyc:PWY-6609|UniProtKB:P0ABP8	DeoD catalyzes both phosphorylase steps. The first is run in the nucleoside-synthetic direction and the third in the phosphorolytic direction; no monomer sufficiency or universal net flux is implied.	"[{""reference_id"": ""UniProtKB:P0ABP8"", ""source_assertion"": ""Reviewed DeoD catalytic-activity comment 3 assigns the matching Rhea reaction family with experimental PMID:235429 attribution. Comment 10 identifies a homohexamer; the enzyme catalyzes reversible phosphorolysis."", ""source_locator"": ""comments[3].reaction; comments[3].reaction.evidences; comments[0]; comments[10]""}, {""reference_id"": ""MetaCyc:INOPHOSPHOR-ENZRXN"", ""source_assertion"": ""The native enzyme-reaction object connects DEOD-CPLX to this reaction and preserves its reversible catalytic scope. The pathway selects the salvage orientation."", ""source_locator"": ""Enzymatic-Reaction[@frameid=\""INOPHOSPHOR-ENZRXN\""]/enzyme; reaction; reaction-direction""}, {""reference_id"": ""MetaCyc:PWY-6609"", ""source_assertion"": ""The four-step pathway selects adenine-to-adenosine synthesis for ADENPHOSPHOR-RXN and inosine-to-hypoxanthine cleavage for INOPHOSPHOR-RXN."", ""source_locator"": ""Pathway[@frameid=\""PWY-6609\""]/reaction-layout""}]"	"[{""id"": ""MetaCyc:INOPHOSPHOR-ENZRXN"", ""source_sha256"": ""0b7da163516b09b0cf91334fee6e255a593e9942cd5a78519a4e7f2b033fb631"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native INOPHOSPHOR-ENZRXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:INOPHOSPHOR-ENZRXN""}, {""id"": ""MetaCyc:PWY-6609"", ""source_sha256"": ""28fbf114b78001e473764dfecdf5f85204819cf318ea458f51539983f998689a"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native PWY-6609"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6609""}, {""id"": ""UniProtKB:P0ABP8"", ""source_sha256"": ""261a1c1e34fcc0af42d3a3b4a16c27a01ecba13eee2437d3f4d8c51e422eed02"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0ABP8"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABP8.json""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-020_c66c028d2071	UniProtKB:P22333	pathwaymech:catalyzes	RHEA:24409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ADENODEAMIN-ENZRXN|MetaCyc:ADENODEAMIN-MONOMER|PMID:765747|UniProtKB:P22333		"[{""reference_id"": ""UniProtKB:P22333"", ""source_assertion"": ""Reviewed catalytic-activity comment 1 assigns adenosine hydrolysis to RHEA:24408 and physiological left-to-right RHEA:24409, with experimental PMID:1998686 and PMID:357905 evidence alongside HAMAP inference."", ""source_locator"": ""comments[1].reaction; comments[1].physiologicalReactions""}, {""reference_id"": ""MetaCyc:ADENODEAMIN-ENZRXN"", ""source_assertion"": ""The native enzyme-reaction object assigns ADENODEAMIN-MONOMER to ADENODEAMIN-RXN."", ""source_locator"": ""Enzymatic-Reaction[@frameid=\""ADENODEAMIN-ENZRXN\""]/enzyme; reaction""}, {""reference_id"": ""MetaCyc:ADENODEAMIN-MONOMER"", ""source_assertion"": ""The native E. coli entity explicitly cross-references P22333; its comment reports a 29 kDa apparent native mass from K-12 gel filtration, not a measured multimeric assembly."", ""source_locator"": ""Protein[@frameid=\""ADENODEAMIN-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]; species; comment""}, {""reference_id"": ""PMID:765747"", ""source_assertion"": ""Adenosine deaminase activity was measured with adenosine, and Table 2 compares add mutants and an add+ transductant under histidine-supplemented conditions that block the alternate histidine-pathway route."", ""source_locator"": ""pp. 86 and 88, Enzyme Assays/Adenosine Deaminase; Table 2 and footnotes""}]"	"[{""id"": ""MetaCyc:ADENODEAMIN-ENZRXN"", ""source_sha256"": ""8a9dac52a3f9e48d31ad863d16e643f0b4dc2de5cebc7d6e4a010829b3a06682"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native ADENODEAMIN-ENZRXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADENODEAMIN-ENZRXN""}, {""id"": ""MetaCyc:ADENODEAMIN-MONOMER"", ""source_sha256"": ""cd205f5ac0648b466801dbb087db3a5e129ec35d19e5482162ac564339020f39"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native ADENODEAMIN-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADENODEAMIN-MONOMER""}, {""id"": ""PMID:765747"", ""source_sha256"": ""a94c9a8e77e5d839c8bbf07444e21bfbf187347f085d99d5f89745e0043bca0f"", ""source_version"": ""Primary full PDF; digest covers original seven-page article"", ""title"": ""Location on the chromosome of Escherichia coli of genes governing purine metabolism. Adenosine deaminase (add), guanosine kinase (gsk) and hypoxanthine phosphoribosyltransferase (hpt)."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/765747/""}, {""id"": ""UniProtKB:P22333"", ""source_sha256"": ""23e32e2f4a9fc0b04d71ef7ccef5441c01b1b100951453b1f47d623fe4782181"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P22333"", ""url"": ""https://rest.uniprot.org/uniprotkb/P22333.json""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-021_76c00863dea7	MetaCyc:CPLX0-7685	pathwaymech:catalyzes	RHEA:17975	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HYPOXANPRIBOSYLTRAN-ENZRXN|UniProtKB:P0A9M2	Hpt preferentially uses hypoxanthine; its role in IMP synthesis is a kinetic interpretation.	"[{""reference_id"": ""UniProtKB:P0A9M2"", ""source_assertion"": ""Reviewed catalytic-activity comment 1 identifies RHEA:17973 and physiological right-to-left RHEA:17975. Hpt preferentially uses hypoxanthine; its role in IMP synthesis is a kinetic interpretation."", ""source_locator"": ""comments[1].reaction; comments[1].physiologicalReactions; comments[0]""}, {""reference_id"": ""MetaCyc:HYPOXANPRIBOSYLTRAN-ENZRXN"", ""source_assertion"": ""The native enzyme-reaction connects CPLX0-7685 to HYPOXANPRIBOSYLTRAN-RXN in its physiological nucleotide-forming direction."", ""source_locator"": ""Enzymatic-Reaction[@frameid=\""HYPOXANPRIBOSYLTRAN-ENZRXN\""]/enzyme; reaction; reaction-direction""}]"	"[{""id"": ""MetaCyc:HYPOXANPRIBOSYLTRAN-ENZRXN"", ""source_sha256"": ""97c84a58a978a0bc5b2c9878ce963ec1127f610eff783f287ffd38567a2f25cb"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native HYPOXANPRIBOSYLTRAN-ENZRXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HYPOXANPRIBOSYLTRAN-ENZRXN""}, {""id"": ""UniProtKB:P0A9M2"", ""source_sha256"": ""e756e863c5c130c05bea5899b81a4a6f23c43402d64e2530cb33ef5465300a1c"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0A9M2"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9M2.json""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-022_80a23a032123	MetaCyc:GPT-CPLX	pathwaymech:catalyzes	RHEA:17975	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HYPXPRIBOSYLTRAN-ENZRXN|UniProtKB:P0A9M5	Gpt also accepts hypoxanthine, with lower affinity than guanine; this is not an equal-flux claim.	"[{""reference_id"": ""UniProtKB:P0A9M5"", ""source_assertion"": ""Reviewed catalytic-activity comment 3 identifies RHEA:17973 and physiological right-to-left RHEA:17975. Gpt also accepts hypoxanthine, with lower affinity than guanine; this is not an equal-flux claim."", ""source_locator"": ""comments[3].reaction; comments[3].physiologicalReactions; comments[0]""}, {""reference_id"": ""MetaCyc:HYPXPRIBOSYLTRAN-ENZRXN"", ""source_assertion"": ""The native enzyme-reaction connects GPT-CPLX to HYPOXANPRIBOSYLTRAN-RXN in its physiological nucleotide-forming direction."", ""source_locator"": ""Enzymatic-Reaction[@frameid=\""HYPXPRIBOSYLTRAN-ENZRXN\""]/enzyme; reaction; reaction-direction""}]"	"[{""id"": ""MetaCyc:HYPXPRIBOSYLTRAN-ENZRXN"", ""source_sha256"": ""362aad6ab4d6408a08f7f77581cbb5414d069953d54c48e7f13e5145c8dd4d56"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native HYPXPRIBOSYLTRAN-ENZRXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HYPXPRIBOSYLTRAN-ENZRXN""}, {""id"": ""UniProtKB:P0A9M5"", ""source_sha256"": ""b0e83f13d146d4d5010d4e6c5762094d5fd99df854859c29444374513e64da01"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0A9M5"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9M5.json""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-023_9642b3e20b5d	UniProtKB:P0ABP8	BFO:0000050	MetaCyc:DEOD-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOD-CPLX|MetaCyc:DEOD-MONOMER|PMID:30337572|UniProtKB:P0ABP8	6 copies per complex. Assembly composition does not make an isolated subunit an independently sufficient catalyst.	"[{""reference_id"": ""MetaCyc:DEOD-CPLX"", ""source_assertion"": ""The native complex component slot specifies 6 copies of DEOD-MONOMER."", ""source_locator"": ""Protein[@frameid=\""DEOD-CPLX\""]/component/Protein; component/coefficient""}, {""reference_id"": ""MetaCyc:DEOD-MONOMER"", ""source_assertion"": ""The native DEOD-MONOMER entity explicitly cross-references UniProt P0ABP8."", ""source_locator"": ""Protein[@frameid=\""DEOD-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:P0ABP8"", ""source_assertion"": ""The reviewed SUBUNIT comment identifies the 6-subunit homooligomer and retains its original experimental citation evidence."", ""source_locator"": ""comments[10].texts; comments[10].texts[0].evidences""}, {""reference_id"": ""PMID:30337572"", ""source_assertion"": ""All PNP structures in the study contain six identical 238-residue chains arranged as a trimer of dimers; the biochemical experiments use purified recombinant enzyme."", ""source_locator"": ""BioC document/passage[40] (zero-based), Results and Discussion/Overall protein structures; passage[63], Methods/Preparation of ternary complexes for crystallisation""}]"	"[{""id"": ""MetaCyc:DEOD-CPLX"", ""source_sha256"": ""f362dcc29babaf5d23e730a329a7c436a0944d811a36ad1adb8ee8569e7962e5"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOD-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOD-CPLX""}, {""id"": ""MetaCyc:DEOD-MONOMER"", ""source_sha256"": ""99f6dcc78816a3a58aab669c0cdaa9a886a0c854dfa8076cbd9a03aa31766893"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOD-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOD-MONOMER""}, {""id"": ""PMID:30337572"", ""source_sha256"": ""1218e2d0107c64412a92a0e365c4bedfa2011eabc73008e9aa8399f20e5b821d"", ""source_version"": ""Primary full text in NCBI BioC XML; digest covers complete response"", ""title"": ""Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/30337572/""}, {""id"": ""UniProtKB:P0ABP8"", ""source_sha256"": ""261a1c1e34fcc0af42d3a3b4a16c27a01ecba13eee2437d3f4d8c51e422eed02"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0ABP8"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABP8.json""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-024_3d9c5a1e8d6d	UniProtKB:P0A9M2	BFO:0000050	MetaCyc:CPLX0-7685	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7685|MetaCyc:HYPOXANPRIBOSYLTRAN-MONOMER|UniProtKB:P0A9M2	4 copies per complex. Assembly composition does not make an isolated subunit an independently sufficient catalyst.	"[{""reference_id"": ""MetaCyc:CPLX0-7685"", ""source_assertion"": ""The native complex component slot specifies 4 copies of HYPOXANPRIBOSYLTRAN-MONOMER."", ""source_locator"": ""Protein[@frameid=\""CPLX0-7685\""]/component/Protein; component/coefficient""}, {""reference_id"": ""MetaCyc:HYPOXANPRIBOSYLTRAN-MONOMER"", ""source_assertion"": ""The native HYPOXANPRIBOSYLTRAN-MONOMER entity explicitly cross-references UniProt P0A9M2."", ""source_locator"": ""Protein[@frameid=\""HYPOXANPRIBOSYLTRAN-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:P0A9M2"", ""source_assertion"": ""The reviewed SUBUNIT comment identifies the 4-subunit homooligomer and retains its original experimental citation evidence."", ""source_locator"": ""comments[7].texts; comments[7].texts[0].evidences""}]"	"[{""id"": ""MetaCyc:CPLX0-7685"", ""source_sha256"": ""f838d1f08ad59faa0c3deca8acc772a25d5b8f1c2758b993a42654f68f5fefa5"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native CPLX0-7685"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7685""}, {""id"": ""MetaCyc:HYPOXANPRIBOSYLTRAN-MONOMER"", ""source_sha256"": ""240392f91c99f2d9036cef375e2b92c8e70a4a62ab3c8233d07fe154510a51e3"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native HYPOXANPRIBOSYLTRAN-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HYPOXANPRIBOSYLTRAN-MONOMER""}, {""id"": ""UniProtKB:P0A9M2"", ""source_sha256"": ""e756e863c5c130c05bea5899b81a4a6f23c43402d64e2530cb33ef5465300a1c"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0A9M2"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9M2.json""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-025_702c3bea79b1	UniProtKB:P0A9M5	BFO:0000050	MetaCyc:GPT-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GPT-CPLX|MetaCyc:GPT-MONOMER|PMID:6305942|PMID:9100006|UniProtKB:P0A9M5	4 copies per complex. The earlier apparent trimer was superseded by later structural evidence for a tetramer.	"[{""reference_id"": ""MetaCyc:GPT-CPLX"", ""source_assertion"": ""The native complex component slot specifies 4 copies of GPT-MONOMER."", ""source_locator"": ""Protein[@frameid=\""GPT-CPLX\""]/component/Protein; component/coefficient""}, {""reference_id"": ""MetaCyc:GPT-MONOMER"", ""source_assertion"": ""The native GPT-MONOMER entity explicitly cross-references UniProt P0A9M5."", ""source_locator"": ""Protein[@frameid=\""GPT-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:P0A9M5"", ""source_assertion"": ""The reviewed SUBUNIT comment identifies the 4-subunit homooligomer and retains its original experimental citation evidence."", ""source_locator"": ""comments[9].texts; comments[9].texts[0].evidences""}, {""reference_id"": ""PMID:9100006"", ""source_assertion"": ""The primary abstract identifies E. coli XPRT as a tetramer and describes hypoxanthine as a substrate yielding IMP."", ""source_locator"": ""resultList.result[id=\""9100006\""].abstractText""}, {""reference_id"": ""PMID:6305942"", ""source_assertion"": ""An earlier gel-filtration study reported trimeric behavior. The graph uses the later tetramer supported by current reviewed annotation and structural studies; the historical discrepancy remains explicit."", ""source_locator"": ""resultList.result[id=\""6305942\""].abstractText""}]"	"[{""id"": ""MetaCyc:GPT-CPLX"", ""source_sha256"": ""f8fd9a52dbf13332ba46fc2db946bc066871d2e3c5466280d3856b49c7a408e9"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native GPT-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GPT-CPLX""}, {""id"": ""MetaCyc:GPT-MONOMER"", ""source_sha256"": ""b58ede2810dd3d3bdadbae5b1163c11ad3fe0ee0b35734c237bb95ebdeda5364"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native GPT-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GPT-MONOMER""}, {""id"": ""PMID:6305942"", ""source_sha256"": ""657fb34a10d3fc68ced4636ad466e07634d8e15ba13374be51d7afea296d267e"", ""source_version"": ""Primary abstract in Europe PMC core batch response; digest covers complete JSON batch"", ""title"": ""Purification and characterization of Escherichia coli guanine-xanthine phosphoribosyltransferase produced by a high efficiency expression plasmid utilizing a lambda PL promoter and CI857 temperature-sensitive repressor."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/6305942/""}, {""id"": ""PMID:9100006"", ""source_sha256"": ""657fb34a10d3fc68ced4636ad466e07634d8e15ba13374be51d7afea296d267e"", ""source_version"": ""Primary abstract in Europe PMC core batch response; digest covers complete JSON batch"", ""title"": ""Crystal structure of Escherichia coli xanthine phosphoribosyltransferase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9100006/""}, {""id"": ""UniProtKB:P0A9M5"", ""source_sha256"": ""b0e83f13d146d4d5010d4e6c5762094d5fd99df854859c29444374513e64da01"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0A9M5"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9M5.json""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-026_f6b8dc7fabfa	UniProtKB:P22333	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P22333	The zinc assignment is explicitly inferred by HAMAP; the inspected K-12 genetic study does not establish zinc binding or stoichiometry.	"[{""reference_id"": ""UniProtKB:P22333"", ""source_assertion"": ""The reviewed cofactor annotation assigns Zn(2+) and one zinc per subunit through ECO:0000255, HAMAP-Rule MF_00540. This is a similarity-based assignment, not a direct E. coli metal-binding experiment."", ""source_locator"": ""comments[3].cofactors; comments[3].note""}]"	"[{""id"": ""UniProtKB:P22333"", ""source_sha256"": ""23e32e2f4a9fc0b04d71ef7ccef5441c01b1b100951453b1f47d623fe4782181"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P22333"", ""url"": ""https://rest.uniprot.org/uniprotkb/P22333.json""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-027_778c899ee7de	MetaCyc:CPLX0-7685	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12070315|UniProtKB:P0A9M2	Metal requirement and structural observation are distinguished from a fixed per-complex metal stoichiometry, which is not asserted.	"[{""reference_id"": ""UniProtKB:P0A9M2"", ""source_assertion"": ""The reviewed magnesium cofactor annotation is ECO:0000305, based on PMID:12070315; the SUBUNIT comment identifies a homotetramer."", ""source_locator"": ""comments[3].cofactors; comments[7]""}, {""reference_id"": ""PMID:12070315"", ""source_assertion"": ""The primary abstract describes a divalent-metal requirement, usually magnesium in vivo, and observes Mg(2+) bound to Glu103/Asp104 in the free E. coli Hpt structure."", ""source_locator"": ""resultList.result[id=\""12070315\""].abstractText""}]"	"[{""id"": ""PMID:12070315"", ""source_sha256"": ""657fb34a10d3fc68ced4636ad466e07634d8e15ba13374be51d7afea296d267e"", ""source_version"": ""Primary abstract in Europe PMC core batch response; digest covers complete JSON batch"", ""title"": ""Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12070315/""}, {""id"": ""UniProtKB:P0A9M2"", ""source_sha256"": ""e756e863c5c130c05bea5899b81a4a6f23c43402d64e2530cb33ef5465300a1c"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0A9M2"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9M2.json""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-028_b7cb78bf9ce2	MetaCyc:GPT-CPLX	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9100006|UniProtKB:P0A9M5		"[{""reference_id"": ""UniProtKB:P0A9M5"", ""source_assertion"": ""The reviewed cofactor annotation assigns Mg(2+) with ECO:0000269 attribution to PMID:9100006."", ""source_locator"": ""comments[4].cofactors""}, {""reference_id"": ""PMID:9100006"", ""source_assertion"": ""The primary abstract reports a magnesium ion at the PRib-PP binding site, interacting with Asp89."", ""source_locator"": ""resultList.result[id=\""9100006\""].abstractText""}]"	"[{""id"": ""PMID:9100006"", ""source_sha256"": ""657fb34a10d3fc68ced4636ad466e07634d8e15ba13374be51d7afea296d267e"", ""source_version"": ""Primary abstract in Europe PMC core batch response; digest covers complete JSON batch"", ""title"": ""Crystal structure of Escherichia coli xanthine phosphoribosyltransferase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9100006/""}, {""id"": ""UniProtKB:P0A9M5"", ""source_sha256"": ""b0e83f13d146d4d5010d4e6c5762094d5fd99df854859c29444374513e64da01"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0A9M5"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9M5.json""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-029_dc274938b5b3	CHEBI:58053	pathwaymech:inhibits	MetaCyc:CPLX0-7685	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9M2	This records the curated enzyme-level product inhibition; no concentration threshold or cellular regulatory strength is inferred.	"[{""reference_id"": ""UniProtKB:P0A9M2"", ""source_assertion"": ""The reviewed activity-regulation comment states inhibition by the product IMP, with ECO:0000269 attribution to PMID:12070315."", ""source_locator"": ""comments[4].texts[0]; comments[4].texts[0].evidences""}]"	"[{""id"": ""UniProtKB:P0A9M2"", ""source_sha256"": ""e756e863c5c130c05bea5899b81a4a6f23c43402d64e2530cb33ef5465300a1c"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0A9M2"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9M2.json""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-030_6c98cbe5f237	UniProtKB:P22333	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P22333		"[{""reference_id"": ""UniProtKB:P22333"", ""source_assertion"": ""The inspected protein record has a GO:0005829 cytosol cross-reference with IDA:EcoCyc attribution. This is the database localization assertion; exclusivity is not implied."", ""source_locator"": ""uniProtKBCrossReferences[database=\""GO\"",id=\""GO:0005829\""].properties""}]"	"[{""id"": ""UniProtKB:P22333"", ""source_sha256"": ""23e32e2f4a9fc0b04d71ef7ccef5441c01b1b100951453b1f47d623fe4782181"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P22333"", ""url"": ""https://rest.uniprot.org/uniprotkb/P22333.json""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-031_492de0a76166	UniProtKB:P0ABP8	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ABP8		"[{""reference_id"": ""UniProtKB:P0ABP8"", ""source_assertion"": ""The inspected protein record has a GO:0005829 cytosol cross-reference with IDA:EcoCyc attribution. This is the database localization assertion; exclusivity is not implied."", ""source_locator"": ""uniProtKBCrossReferences[database=\""GO\"",id=\""GO:0005829\""].properties""}]"	"[{""id"": ""UniProtKB:P0ABP8"", ""source_sha256"": ""261a1c1e34fcc0af42d3a3b4a16c27a01ecba13eee2437d3f4d8c51e422eed02"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0ABP8"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABP8.json""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-032_d7666ecac45c	UniProtKB:P0A9M2	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9M2		"[{""reference_id"": ""UniProtKB:P0A9M2"", ""source_assertion"": ""The inspected protein record has a GO:0005829 cytosol cross-reference with IDA:EcoCyc attribution. This is the database localization assertion; exclusivity is not implied."", ""source_locator"": ""uniProtKBCrossReferences[database=\""GO\"",id=\""GO:0005829\""].properties""}]"	"[{""id"": ""UniProtKB:P0A9M2"", ""source_sha256"": ""e756e863c5c130c05bea5899b81a4a6f23c43402d64e2530cb33ef5465300a1c"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0A9M2"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9M2.json""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-033_eef5c4ad0af6	UniProtKB:P0A9M5	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9M5		"[{""reference_id"": ""UniProtKB:P0A9M5"", ""source_assertion"": ""The inspected protein record has a GO:0005829 cytosol cross-reference with IDA:EcoCyc attribution. This is the database localization assertion; exclusivity is not implied."", ""source_locator"": ""uniProtKBCrossReferences[database=\""GO\"",id=\""GO:0005829\""].properties""}]"	"[{""id"": ""UniProtKB:P0A9M5"", ""source_sha256"": ""b0e83f13d146d4d5010d4e6c5762094d5fd99df854859c29444374513e64da01"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0A9M5"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9M5.json""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-034_2a17626ef1dd	UniProtKB:P0ABP8	RO:0001025	GO:0016020	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ABP8	This source-specific localization evidence is retained with its evidence tier; it does not move the whole pathway into this compartment.	"[{""reference_id"": ""UniProtKB:P0ABP8"", ""source_assertion"": ""The inspected protein record also has a GO:0016020 localization cross-reference with HDA:UniProtKB attribution, alongside its cytosol annotation. The annotations do not establish exclusive localization."", ""source_locator"": ""uniProtKBCrossReferences[database=\""GO\"",id=\""GO:0016020\""].properties""}]"	"[{""id"": ""UniProtKB:P0ABP8"", ""source_sha256"": ""261a1c1e34fcc0af42d3a3b4a16c27a01ecba13eee2437d3f4d8c51e422eed02"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0ABP8"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABP8.json""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-035_1db5dfcf7eaa	UniProtKB:P0A9M5	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9M5	This source-specific localization evidence is retained with its evidence tier; it does not move the whole pathway into this compartment.	"[{""reference_id"": ""UniProtKB:P0A9M5"", ""source_assertion"": ""The inspected protein record also has a GO:0005886 localization cross-reference with IEA:UniProtKB-SubCell attribution, alongside its cytosol annotation. The annotations do not establish exclusive localization."", ""source_locator"": ""uniProtKBCrossReferences[database=\""GO\"",id=\""GO:0005886\""].properties""}]"	"[{""id"": ""UniProtKB:P0A9M5"", ""source_sha256"": ""b0e83f13d146d4d5010d4e6c5762094d5fd99df854859c29444374513e64da01"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0A9M5"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9M5.json""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-036_accd2a425e35	RHEA:27644	BFO:0000050	MetaCyc:PWY-6609	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ADENPHOSPHOR-RXN|MetaCyc:PWY-6609|RHEA:27644		"[{""reference_id"": ""MetaCyc:PWY-6609"", ""source_assertion"": ""The native complete pathway includes ADENPHOSPHOR-RXN; its reaction-layout selects the orientation used here."", ""source_locator"": ""Pathway[@frameid=\""PWY-6609\""]/reaction-list; reaction-layout""}, {""reference_id"": ""MetaCyc:ADENPHOSPHOR-RXN"", ""source_assertion"": ""Native ADENPHOSPHOR-RXN has Rhea cross-reference 27645. Its chemical roles match the selected Rhea family; protonation is retained from exact Rhea species rather than asserted as an exactMatch between differing source chemical forms."", ""source_locator"": ""Reaction[@frameid=\""ADENPHOSPHOR-RXN\""]/dblink[dblink-db=\""RHEA\""]; left; right; reaction-direction""}, {""reference_id"": ""RHEA:27644"", ""source_assertion"": ""Rhea master 27642 explicitly links directional member 27644 and bidirectional member 27645."", ""source_locator"": ""rhea.rdf.gz; rh:27642 rh:directionalReaction rh:27644; rh:27642 rh:bidirectionalReaction rh:27645""}]"	"[{""id"": ""MetaCyc:ADENPHOSPHOR-RXN"", ""source_sha256"": ""57c09f3b3b8955e3a7139292e0c3bd0506d4a467782d15099439c22cff29817b"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native ADENPHOSPHOR-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADENPHOSPHOR-RXN""}, {""id"": ""MetaCyc:PWY-6609"", ""source_sha256"": ""28fbf114b78001e473764dfecdf5f85204819cf318ea458f51539983f998689a"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native PWY-6609"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6609""}, {""id"": ""RHEA:27644"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 27644"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-037_bb6d2717d24b	RHEA:24409	BFO:0000050	MetaCyc:PWY-6609	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ADENODEAMIN-RXN|MetaCyc:PWY-6609|RHEA:24409		"[{""reference_id"": ""MetaCyc:PWY-6609"", ""source_assertion"": ""The native complete pathway includes ADENODEAMIN-RXN; its reaction-layout selects the orientation used here."", ""source_locator"": ""Pathway[@frameid=\""PWY-6609\""]/reaction-list; reaction-layout""}, {""reference_id"": ""MetaCyc:ADENODEAMIN-RXN"", ""source_assertion"": ""Native ADENODEAMIN-RXN has Rhea cross-reference 24408. Its chemical roles match the selected Rhea family; protonation is retained from exact Rhea species rather than asserted as an exactMatch between differing source chemical forms."", ""source_locator"": ""Reaction[@frameid=\""ADENODEAMIN-RXN\""]/dblink[dblink-db=\""RHEA\""]; left; right; reaction-direction""}, {""reference_id"": ""RHEA:24409"", ""source_assertion"": ""Rhea master 24408 explicitly links directional member 24409."", ""source_locator"": ""rhea.rdf.gz; rh:24408 rh:directionalReaction rh:24409""}]"	"[{""id"": ""MetaCyc:ADENODEAMIN-RXN"", ""source_sha256"": ""0e943b5c6389a1eb36c32a8272ba60e07e413e8cf0dd5f68ab88972f47f973c6"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native ADENODEAMIN-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADENODEAMIN-RXN""}, {""id"": ""MetaCyc:PWY-6609"", ""source_sha256"": ""28fbf114b78001e473764dfecdf5f85204819cf318ea458f51539983f998689a"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native PWY-6609"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6609""}, {""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 24409"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-038_50bd0a3bd05d	RHEA:27647	BFO:0000050	MetaCyc:PWY-6609	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:INOPHOSPHOR-RXN|MetaCyc:PWY-6609|RHEA:27647		"[{""reference_id"": ""MetaCyc:PWY-6609"", ""source_assertion"": ""The native complete pathway includes INOPHOSPHOR-RXN; its reaction-layout selects the orientation used here."", ""source_locator"": ""Pathway[@frameid=\""PWY-6609\""]/reaction-list; reaction-layout""}, {""reference_id"": ""MetaCyc:INOPHOSPHOR-RXN"", ""source_assertion"": ""Native INOPHOSPHOR-RXN has Rhea cross-reference 27649. Its chemical roles match the selected Rhea family; protonation is retained from exact Rhea species rather than asserted as an exactMatch between differing source chemical forms."", ""source_locator"": ""Reaction[@frameid=\""INOPHOSPHOR-RXN\""]/dblink[dblink-db=\""RHEA\""]; left; right; reaction-direction""}, {""reference_id"": ""RHEA:27647"", ""source_assertion"": ""Rhea master 27646 explicitly links directional member 27647 and bidirectional member 27649."", ""source_locator"": ""rhea.rdf.gz; rh:27646 rh:directionalReaction rh:27647; rh:27646 rh:bidirectionalReaction rh:27649""}]"	"[{""id"": ""MetaCyc:INOPHOSPHOR-RXN"", ""source_sha256"": ""f5a1902beb3761e62a39b355da9242e4176f1e2062f229bcf20408d37c1e8494"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native INOPHOSPHOR-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:INOPHOSPHOR-RXN""}, {""id"": ""MetaCyc:PWY-6609"", ""source_sha256"": ""28fbf114b78001e473764dfecdf5f85204819cf318ea458f51539983f998689a"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native PWY-6609"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6609""}, {""id"": ""RHEA:27647"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 27647"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-039_8af0c56893f2	RHEA:17975	BFO:0000050	MetaCyc:PWY-6609	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HYPOXANPRIBOSYLTRAN-RXN|MetaCyc:PWY-6609|RHEA:17975		"[{""reference_id"": ""MetaCyc:PWY-6609"", ""source_assertion"": ""The native complete pathway includes HYPOXANPRIBOSYLTRAN-RXN; its reaction-layout selects the orientation used here."", ""source_locator"": ""Pathway[@frameid=\""PWY-6609\""]/reaction-list; reaction-layout""}, {""reference_id"": ""MetaCyc:HYPOXANPRIBOSYLTRAN-RXN"", ""source_assertion"": ""Native HYPOXANPRIBOSYLTRAN-RXN has Rhea cross-reference 17973. Its chemical roles match the selected Rhea family; protonation is retained from exact Rhea species rather than asserted as an exactMatch between differing source chemical forms."", ""source_locator"": ""Reaction[@frameid=\""HYPOXANPRIBOSYLTRAN-RXN\""]/dblink[dblink-db=\""RHEA\""]; left; right; reaction-direction""}, {""reference_id"": ""RHEA:17975"", ""source_assertion"": ""Rhea master 17973 explicitly links directional member 17975."", ""source_locator"": ""rhea.rdf.gz; rh:17973 rh:directionalReaction rh:17975""}]"	"[{""id"": ""MetaCyc:HYPOXANPRIBOSYLTRAN-RXN"", ""source_sha256"": ""aaf5f09db6d4cb404a9687b5996a2121c16bcf891bb51141d5d8ee6320ec99b8"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native HYPOXANPRIBOSYLTRAN-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HYPOXANPRIBOSYLTRAN-RXN""}, {""id"": ""MetaCyc:PWY-6609"", ""source_sha256"": ""28fbf114b78001e473764dfecdf5f85204819cf318ea458f51539983f998689a"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native PWY-6609"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6609""}, {""id"": ""RHEA:17975"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 17975"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-040_1f1c8d9f42c3	RHEA:27644	RO:0002413	RHEA:24409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6609|PMID:765747|RHEA:24409|RHEA:27644	The shared metabolite supplies the next reaction. This is material connectivity, not a claim of direct enzyme channeling or exclusive flux.	"[{""reference_id"": ""MetaCyc:PWY-6609"", ""source_assertion"": ""The pathway lists ADENPHOSPHOR-RXN as the predecessor of ADENODEAMIN-RXN."", ""source_locator"": ""Pathway[@frameid=\""PWY-6609\""]/reaction-ordering[Reaction/@frameid=\""ADENODEAMIN-RXN\""]""}, {""reference_id"": ""PMID:765747"", ""source_assertion"": ""Figure 1 places purine nucleoside phosphorylase and adenosine deaminase between adenine, adenosine, inosine and hypoxanthine, with phosphoribosyltransferases forming IMP. Table 1 identifies K-12-derived strains; the figure also depicts distinct alternative routes."", ""source_locator"": ""p. 85 Figure 1 and caption; p. 87 Table 1; p. 90 Figure 3 caption""}, {""reference_id"": ""RHEA:27644"", ""source_assertion"": ""RHEA:27644 explicitly lists CHEBI:16335 as a product with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:27644 rh:products <http://rdf.rhea-db.org/27642_L>; <http://rdf.rhea-db.org/27642_L> rh:contains1 <http://rdf.rhea-db.org/Participant_27642_compound_2547>; <http://rdf.rhea-db.org/Participant_27642_compound_2547> rh:compound <http://rdf.rhea-db.org/Compound_2547> / rh:chebi""}, {""reference_id"": ""RHEA:24409"", ""source_assertion"": ""RHEA:24409 explicitly lists CHEBI:16335 as a substrate with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:substrates <http://rdf.rhea-db.org/24408_L>; <http://rdf.rhea-db.org/24408_L> rh:contains1 <http://rdf.rhea-db.org/Participant_24408_compound_2547>; <http://rdf.rhea-db.org/Participant_24408_compound_2547> rh:compound <http://rdf.rhea-db.org/Compound_2547> / rh:chebi""}]"	"[{""id"": ""MetaCyc:PWY-6609"", ""source_sha256"": ""28fbf114b78001e473764dfecdf5f85204819cf318ea458f51539983f998689a"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native PWY-6609"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6609""}, {""id"": ""PMID:765747"", ""source_sha256"": ""a94c9a8e77e5d839c8bbf07444e21bfbf187347f085d99d5f89745e0043bca0f"", ""source_version"": ""Primary full PDF; digest covers original seven-page article"", ""title"": ""Location on the chromosome of Escherichia coli of genes governing purine metabolism. Adenosine deaminase (add), guanosine kinase (gsk) and hypoxanthine phosphoribosyltransferase (hpt)."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/765747/""}, {""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 24409"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:27644"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 27644"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-041_8449bff9355a	RHEA:24409	RO:0002413	RHEA:27647	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6609|PMID:765747|RHEA:24409|RHEA:27647	The shared metabolite supplies the next reaction. This is material connectivity, not a claim of direct enzyme channeling or exclusive flux.	"[{""reference_id"": ""MetaCyc:PWY-6609"", ""source_assertion"": ""The pathway lists ADENODEAMIN-RXN as the predecessor of INOPHOSPHOR-RXN."", ""source_locator"": ""Pathway[@frameid=\""PWY-6609\""]/reaction-ordering[Reaction/@frameid=\""INOPHOSPHOR-RXN\""]""}, {""reference_id"": ""PMID:765747"", ""source_assertion"": ""Figure 1 places purine nucleoside phosphorylase and adenosine deaminase between adenine, adenosine, inosine and hypoxanthine, with phosphoribosyltransferases forming IMP. Table 1 identifies K-12-derived strains; the figure also depicts distinct alternative routes."", ""source_locator"": ""p. 85 Figure 1 and caption; p. 87 Table 1; p. 90 Figure 3 caption""}, {""reference_id"": ""RHEA:24409"", ""source_assertion"": ""RHEA:24409 explicitly lists CHEBI:17596 as a product with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:products <http://rdf.rhea-db.org/24408_R>; <http://rdf.rhea-db.org/24408_R> rh:contains1 <http://rdf.rhea-db.org/Participant_24408_compound_1231>; <http://rdf.rhea-db.org/Participant_24408_compound_1231> rh:compound <http://rdf.rhea-db.org/Compound_1231> / rh:chebi""}, {""reference_id"": ""RHEA:27647"", ""source_assertion"": ""RHEA:27647 explicitly lists CHEBI:17596 as a substrate with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:27647 rh:substrates <http://rdf.rhea-db.org/27646_L>; <http://rdf.rhea-db.org/27646_L> rh:contains1 <http://rdf.rhea-db.org/Participant_27646_compound_1231>; <http://rdf.rhea-db.org/Participant_27646_compound_1231> rh:compound <http://rdf.rhea-db.org/Compound_1231> / rh:chebi""}]"	"[{""id"": ""MetaCyc:PWY-6609"", ""source_sha256"": ""28fbf114b78001e473764dfecdf5f85204819cf318ea458f51539983f998689a"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native PWY-6609"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6609""}, {""id"": ""PMID:765747"", ""source_sha256"": ""a94c9a8e77e5d839c8bbf07444e21bfbf187347f085d99d5f89745e0043bca0f"", ""source_version"": ""Primary full PDF; digest covers original seven-page article"", ""title"": ""Location on the chromosome of Escherichia coli of genes governing purine metabolism. Adenosine deaminase (add), guanosine kinase (gsk) and hypoxanthine phosphoribosyltransferase (hpt)."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/765747/""}, {""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 24409"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:27647"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 27647"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6609_adenine-salvage-edge-042_35b345f0de13	RHEA:27647	RO:0002413	RHEA:17975	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6609|PMID:765747|RHEA:17975|RHEA:27647	The shared metabolite supplies the next reaction. This is material connectivity, not a claim of direct enzyme channeling or exclusive flux.	"[{""reference_id"": ""MetaCyc:PWY-6609"", ""source_assertion"": ""The pathway lists INOPHOSPHOR-RXN as the predecessor of HYPOXANPRIBOSYLTRAN-RXN."", ""source_locator"": ""Pathway[@frameid=\""PWY-6609\""]/reaction-ordering[Reaction/@frameid=\""HYPOXANPRIBOSYLTRAN-RXN\""]""}, {""reference_id"": ""PMID:765747"", ""source_assertion"": ""Figure 1 places purine nucleoside phosphorylase and adenosine deaminase between adenine, adenosine, inosine and hypoxanthine, with phosphoribosyltransferases forming IMP. Table 1 identifies K-12-derived strains; the figure also depicts distinct alternative routes."", ""source_locator"": ""p. 85 Figure 1 and caption; p. 87 Table 1; p. 90 Figure 3 caption""}, {""reference_id"": ""RHEA:27647"", ""source_assertion"": ""RHEA:27647 explicitly lists CHEBI:17368 as a product with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:27647 rh:products <http://rdf.rhea-db.org/27646_R>; <http://rdf.rhea-db.org/27646_R> rh:contains1 <http://rdf.rhea-db.org/Participant_27646_compound_3881>; <http://rdf.rhea-db.org/Participant_27646_compound_3881> rh:compound <http://rdf.rhea-db.org/Compound_3881> / rh:chebi""}, {""reference_id"": ""RHEA:17975"", ""source_assertion"": ""RHEA:17975 explicitly lists CHEBI:17368 as a substrate with coefficient 1. Formula and charge are those of the linked Rhea compound and ChEBI species."", ""source_locator"": ""rhea.rdf.gz; rh:17975 rh:substrates <http://rdf.rhea-db.org/17973_R>; <http://rdf.rhea-db.org/17973_R> rh:contains1 <http://rdf.rhea-db.org/Participant_17973_compound_3881>; <http://rdf.rhea-db.org/Participant_17973_compound_3881> rh:compound <http://rdf.rhea-db.org/Compound_3881> / rh:chebi""}]"	"[{""id"": ""MetaCyc:PWY-6609"", ""source_sha256"": ""28fbf114b78001e473764dfecdf5f85204819cf318ea458f51539983f998689a"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native PWY-6609"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6609""}, {""id"": ""PMID:765747"", ""source_sha256"": ""a94c9a8e77e5d839c8bbf07444e21bfbf187347f085d99d5f89745e0043bca0f"", ""source_version"": ""Primary full PDF; digest covers original seven-page article"", ""title"": ""Location on the chromosome of Escherichia coli of genes governing purine metabolism. Adenosine deaminase (add), guanosine kinase (gsk) and hypoxanthine phosphoribosyltransferase (hpt)."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/765747/""}, {""id"": ""RHEA:17975"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 17975"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:27647"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete original RDF gzip"", ""title"": ""Rhea directed reaction 27647"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-001_0c5562f34932	gomodel:YeastPathways_PWY-7220-1/6a2b236300005372	RO:0002233	CHEBI:15967	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7220-1/6a2b236300005372 RO:0002233 gomodel:YeastPathways_PWY-7220-1/6a2b236300005373."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/0; endpoint types: /individuals/38/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-002_e043c490f89d	gomodel:YeastPathways_PWY-7220-1/6a2b236300005372	RO:0002233	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7220-1/6a2b236300005372 RO:0002233 gomodel:YeastPathways_PWY-7220-1/6a2b236300005374."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/1; endpoint types: /individuals/38/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-003_34565ee43d4f	gomodel:ADPREDUCT-RXN	RO:0002234	CHEBI:57667	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:ADPREDUCT-RXN RO:0002234 gomodel:CHEBI_57667_ADPREDUCT-RXN."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/2; endpoint types: /individuals/0/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-004_a47fb4193b31	gomodel:ADPREDUCT-RXN	RO:0002234	CHEBI:18191	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:ADPREDUCT-RXN RO:0002234 gomodel:YeastPathways_PWY-7220-1/66a3e0bb00000654."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/3; endpoint types: /individuals/0/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-008_c2edc934bd12	gomodel:ADPREDUCT-RXN	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:ADPREDUCT-RXN RO:0002234 gomodel:CHEBI_15377_ADPREDUCT-RXN."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/7; endpoint types: /individuals/0/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-009_2311140f18af	gomodel:YeastPathways_PWY-7220-1/6a2b236300005372	RO:0002234	CHEBI:57667	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7220-1/6a2b236300005372 RO:0002234 gomodel:CHEBI_57667_ADPREDUCT-RXN."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/8; endpoint types: /individuals/38/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-011_3b080cec7c0f	SGD:S000217933	pathwaymech:enables	gomodel:ADPREDUCT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:6370695|gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:ADPREDUCT-RXN RO:0002333 gomodel:YeastPathways_PWY-7220-1/66a3e0bb00000651."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/10; endpoint types: /individuals/0/type; /individuals/53/type""}, {""reference_id"": ""PMID:6370695"", ""source_assertion"": ""The characterized yeast ribonucleotide reductase reduces all four natural ribonucleoside diphosphates; ADP reduction yields the dADP precursor used in this route."", ""source_locator"": ""https://pubmed.ncbi.nlm.nih.gov/6370695/#abstract""}]"	"[{""id"": ""PMID:6370695"", ""title"": ""Deoxyribonucleotide biosynthesis in yeast (Saccharomyces cerevisiae). A ribonucleotide reductase system of sufficient activity for DNA synthesis"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/6370695/""}, {""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-012_5f211175f242	SGD:S000217934	pathwaymech:enables	gomodel:YeastPathways_PWY-7220-1/6a2b236300005372	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:6370695|gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7220-1/6a2b236300005372 RO:0002333 gomodel:YeastPathways_PWY-7220-1/6a2b236300005378."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/11; endpoint types: /individuals/38/type; /individuals/43/type""}, {""reference_id"": ""PMID:6370695"", ""source_assertion"": ""The characterized yeast ribonucleotide reductase reduces all four natural ribonucleoside diphosphates; ADP reduction yields the dADP precursor used in this route."", ""source_locator"": ""https://pubmed.ncbi.nlm.nih.gov/6370695/#abstract""}]"	"[{""id"": ""PMID:6370695"", ""title"": ""Deoxyribonucleotide biosynthesis in yeast (Saccharomyces cerevisiae). A ribonucleotide reductase system of sufficient activity for DNA synthesis"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/6370695/""}, {""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-014_86820e91c6c9	gomodel:DADPKIN-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:DADPKIN-RXN RO:0002234 gomodel:CHEBI_456216_DADPKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/13; endpoint types: /individuals/13/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-015_5d59475ccf76	gomodel:YeastPathways_PWY-7220-1/6a2b236300005372	RO:0002234	CHEBI:18191	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7220-1/6a2b236300005372 RO:0002234 gomodel:YeastPathways_PWY-7220-1/6a2b236300005375."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/14; endpoint types: /individuals/38/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-016_43faeab3f85f	SGD:S000001550	pathwaymech:enables	gomodel:DADPKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:DADPKIN-RXN RO:0002333 gomodel:YKL067W-MONOMER_DADPKIN-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/15; endpoint types: /individuals/13/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-017_ee12d5549fc5	gomodel:YeastPathways_PWY-7220-1/6a2b236300005372	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7220-1/6a2b236300005372 RO:0002234 gomodel:YeastPathways_PWY-7220-1/6a2b236300005376."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/16; endpoint types: /individuals/38/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-018_e37d5c1eb3c1	gomodel:DADPKIN-RXN	RO:0002233	CHEBI:57667	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:DADPKIN-RXN RO:0002233 gomodel:CHEBI_57667_ADPREDUCT-RXN."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/17; endpoint types: /individuals/13/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-019_82e1690967fe	gomodel:DADPKIN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:DADPKIN-RXN BFO:0000066 gomodel:reaction_DADPKIN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/18; endpoint types: /individuals/13/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-020_5c8f4d87db8f	gomodel:YeastPathways_PWY-7220-1/6a2b236300005372	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7220-1/6a2b236300005372 BFO:0000066 gomodel:YeastPathways_PWY-7220-1/6a2b236300005379."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/19; endpoint types: /individuals/38/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-022_602c6a524e5c	gomodel:ADPREDUCT-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:ADPREDUCT-RXN BFO:0000066 gomodel:reaction_ADPREDUCT-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/21; endpoint types: /individuals/0/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-023_2f5b7a85fa23	gomodel:YeastPathways_PWY-7220-1/6a2b236300005372	BFO:0000050	GO:0046085	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7220-1/6a2b236300005372 BFO:0000050 gomodel:YeastPathways_PWY-7220-1/YeastPathways_PWY-7220-1."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/22; endpoint types: /individuals/38/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-025_0b9e83fa5a5b	gomodel:DADPKIN-RXN	BFO:0000050	GO:0046085	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:DADPKIN-RXN BFO:0000050 gomodel:YeastPathways_PWY-7220-1/YeastPathways_PWY-7220-1."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/24; endpoint types: /individuals/13/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-026_03be3038d655	gomodel:ADPREDUCT-RXN	BFO:0000050	GO:0046085	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:ADPREDUCT-RXN BFO:0000050 gomodel:YeastPathways_PWY-7220-1/YeastPathways_PWY-7220-1."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/25; endpoint types: /individuals/0/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-027_fbc69ad0928f	gomodel:DADPKIN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:DADPKIN-RXN RO:0002233 gomodel:CHEBI_30616_DADPKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/26; endpoint types: /individuals/13/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-028_b0adce56faa6	gomodel:ADPREDUCT-RXN	RO:0002233	CHEBI:15967	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:ADPREDUCT-RXN RO:0002233 gomodel:YeastPathways_PWY-7220-1/66a3e0bb00000653."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/27; endpoint types: /individuals/0/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-030_ec97311c9625	gomodel:ADPREDUCT-RXN	RO:0002233	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:ADPREDUCT-RXN RO:0002233 gomodel:CHEBI_456216_ADPREDUCT-RXN."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/29; endpoint types: /individuals/0/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_edge-032_7c78082a3db2	gomodel:DADPKIN-RXN	RO:0002234	CHEBI:61404	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7220-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_assertion"": ""The model asserts gomodel:DADPKIN-RXN RO:0002234 gomodel:CHEBI_61404_DADPKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7220-1.json#/facts/31; endpoint types: /individuals/13/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7220-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-7220-1.json"", ""title"": ""GO-CAM adenosine deoxyribonucleotides de novo biosynthesis II model YeastPathways_PWY-7220-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_complex-5603663c8d9f_433db256bb8c	SGD:S000217933	BFO:0000051	CHEBI:24875	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217933	ECO:0000353: physical interaction evidence; source stoichiometry minValue: 2, maxValue: 2	"[{""reference_id"": ""SGD:S000217933"", ""source_assertion"": ""Complex Portal CPX-1102 lists CHEBI:24875 as a small molecule component; complex evidence is ECO:0000353: physical interaction evidence."", ""source_locator"": ""Complex Portal JSON #/participants/0; /evidenceType""}]"	"[{""id"": ""SGD:S000217933"", ""source_sha256"": ""3b80bfeea3253ea8096bc19dba2bdb6a7279f9b740df221e90b4d11fc74d27b3"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-1102: Ribonucleoside-diphosphate reductase variant 1"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1102""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_complex-42e98d8701be_cb51f50e2f07	SGD:S000217933	BFO:0000051	UniProtKB:P21524	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217933	ECO:0000353: physical interaction evidence; source stoichiometry minValue: 2, maxValue: 2	"[{""reference_id"": ""SGD:S000217933"", ""source_assertion"": ""Complex Portal CPX-1102 lists P21524 as a protein component; complex evidence is ECO:0000353: physical interaction evidence."", ""source_locator"": ""Complex Portal JSON #/participants/1; /evidenceType""}]"	"[{""id"": ""SGD:S000217933"", ""source_sha256"": ""3b80bfeea3253ea8096bc19dba2bdb6a7279f9b740df221e90b4d11fc74d27b3"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-1102: Ribonucleoside-diphosphate reductase variant 1"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1102""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_complex-efa6fb5ae30b_92278d5cc441	SGD:S000217933	BFO:0000051	UniProtKB:P09938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217933	ECO:0000353: physical interaction evidence; source stoichiometry minValue: 1, maxValue: 1	"[{""reference_id"": ""SGD:S000217933"", ""source_assertion"": ""Complex Portal CPX-1102 lists P09938 as a protein component; complex evidence is ECO:0000353: physical interaction evidence."", ""source_locator"": ""Complex Portal JSON #/participants/2; /evidenceType""}]"	"[{""id"": ""SGD:S000217933"", ""source_sha256"": ""3b80bfeea3253ea8096bc19dba2bdb6a7279f9b740df221e90b4d11fc74d27b3"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-1102: Ribonucleoside-diphosphate reductase variant 1"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1102""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_complex-587f05f5e8b7_e12b2a9c4286	SGD:S000217933	BFO:0000051	UniProtKB:P49723	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217933	ECO:0000353: physical interaction evidence; source stoichiometry minValue: 1, maxValue: 1	"[{""reference_id"": ""SGD:S000217933"", ""source_assertion"": ""Complex Portal CPX-1102 lists P49723 as a protein component; complex evidence is ECO:0000353: physical interaction evidence."", ""source_locator"": ""Complex Portal JSON #/participants/3; /evidenceType""}]"	"[{""id"": ""SGD:S000217933"", ""source_sha256"": ""3b80bfeea3253ea8096bc19dba2bdb6a7279f9b740df221e90b4d11fc74d27b3"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-1102: Ribonucleoside-diphosphate reductase variant 1"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1102""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_complex-841e721b9255_cff2317cade7	SGD:S000217933	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217933	Complex location from the independent composition source; original GO-CAM activity locations are retained with their own provenance.	"[{""reference_id"": ""SGD:S000217933"", ""source_assertion"": ""Complex Portal CPX-1102 records cellular location GO:0005737 (cytoplasm); its evidence classification is ECO:0000353: physical interaction evidence."", ""source_locator"": ""Complex Portal JSON #/crossReferences/11; /evidenceType""}]"	"[{""id"": ""SGD:S000217933"", ""source_sha256"": ""3b80bfeea3253ea8096bc19dba2bdb6a7279f9b740df221e90b4d11fc74d27b3"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-1102: Ribonucleoside-diphosphate reductase variant 1"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1102""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_complex-98c1e5c9787f_4f6245fe62d2	SGD:S000217934	BFO:0000051	CHEBI:24875	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217934	ECO:0005546: inferred by paralogy; source stoichiometry minValue: 2, maxValue: 2	"[{""reference_id"": ""SGD:S000217934"", ""source_assertion"": ""Complex Portal CPX-1103 lists CHEBI:24875 as a small molecule component; complex evidence is ECO:0005546: inferred by paralogy."", ""source_locator"": ""Complex Portal JSON #/participants/0; /evidenceType""}]"	"[{""id"": ""SGD:S000217934"", ""source_sha256"": ""9bb6e64da63637d23ca711307b6346300830216e362d243513a00add60d6680b"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-1103: Ribonucleoside-diphosphate reductase variant 2"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1103""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_complex-93b1ae113c51_4917d5481121	SGD:S000217934	BFO:0000051	UniProtKB:P21524	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217934	ECO:0005546: inferred by paralogy; source stoichiometry minValue: 1, maxValue: 1	"[{""reference_id"": ""SGD:S000217934"", ""source_assertion"": ""Complex Portal CPX-1103 lists P21524 as a protein component; complex evidence is ECO:0005546: inferred by paralogy."", ""source_locator"": ""Complex Portal JSON #/participants/1; /evidenceType""}]"	"[{""id"": ""SGD:S000217934"", ""source_sha256"": ""9bb6e64da63637d23ca711307b6346300830216e362d243513a00add60d6680b"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-1103: Ribonucleoside-diphosphate reductase variant 2"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1103""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_complex-1912c9b0bd1d_48b913af544c	SGD:S000217934	BFO:0000051	UniProtKB:P09938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217934	ECO:0005546: inferred by paralogy; source stoichiometry minValue: 1, maxValue: 1	"[{""reference_id"": ""SGD:S000217934"", ""source_assertion"": ""Complex Portal CPX-1103 lists P09938 as a protein component; complex evidence is ECO:0005546: inferred by paralogy."", ""source_locator"": ""Complex Portal JSON #/participants/2; /evidenceType""}]"	"[{""id"": ""SGD:S000217934"", ""source_sha256"": ""9bb6e64da63637d23ca711307b6346300830216e362d243513a00add60d6680b"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-1103: Ribonucleoside-diphosphate reductase variant 2"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1103""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_complex-1893fb368ea7_47d8b4849565	SGD:S000217934	BFO:0000051	UniProtKB:P21672	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217934	ECO:0005546: inferred by paralogy; source stoichiometry minValue: 1, maxValue: 1	"[{""reference_id"": ""SGD:S000217934"", ""source_assertion"": ""Complex Portal CPX-1103 lists P21672 as a protein component; complex evidence is ECO:0005546: inferred by paralogy."", ""source_locator"": ""Complex Portal JSON #/participants/3; /evidenceType""}]"	"[{""id"": ""SGD:S000217934"", ""source_sha256"": ""9bb6e64da63637d23ca711307b6346300830216e362d243513a00add60d6680b"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-1103: Ribonucleoside-diphosphate reductase variant 2"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1103""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_complex-28539cb6b6b0_3c49a8ddbc7e	SGD:S000217934	BFO:0000051	UniProtKB:P49723	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217934	ECO:0005546: inferred by paralogy; source stoichiometry minValue: 1, maxValue: 1	"[{""reference_id"": ""SGD:S000217934"", ""source_assertion"": ""Complex Portal CPX-1103 lists P49723 as a protein component; complex evidence is ECO:0005546: inferred by paralogy."", ""source_locator"": ""Complex Portal JSON #/participants/4; /evidenceType""}]"	"[{""id"": ""SGD:S000217934"", ""source_sha256"": ""9bb6e64da63637d23ca711307b6346300830216e362d243513a00add60d6680b"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-1103: Ribonucleoside-diphosphate reductase variant 2"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1103""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_complex-7e078717e822_ec4861434ab4	SGD:S000217934	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217934	Complex location from the independent composition source; original GO-CAM activity locations are retained with their own provenance.	"[{""reference_id"": ""SGD:S000217934"", ""source_assertion"": ""Complex Portal CPX-1103 records cellular location GO:0005737 (cytoplasm); its evidence classification is ECO:0005546: inferred by paralogy."", ""source_locator"": ""Complex Portal JSON #/crossReferences/5; /evidenceType""}]"	"[{""id"": ""SGD:S000217934"", ""source_sha256"": ""9bb6e64da63637d23ca711307b6346300830216e362d243513a00add60d6680b"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-1103: Ribonucleoside-diphosphate reductase variant 2"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1103""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_location-77bf27fc8523_0a98a32dcce0	SGD:S000001550	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36010	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12472466) Source qualification: Localizes predominantly to the cytoplasm. A small fraction is present in the mitochondrial intermembrane space	"[{""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 has the exact SGD cross-reference SGD:S000001550."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P36010"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36010 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_location-551208086c3a_c68ec500393c	SGD:S000001550	RO:0001025	GO:0005758	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36010	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12472466); ECO:0000269 (PubMed:16823961); ECO:0000269 (PubMed:22984289) Source qualification: Localizes predominantly to the cytoplasm. A small fraction is present in the mitochondrial intermembrane space	"[{""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 annotates location Mitochondrion intermembrane space (SL-0169)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 has the exact SGD cross-reference SGD:S000001550."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P36010"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36010 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_location-4533daa0d294_2886d4084e86	UniProtKB:P21524	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P21524	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12732713)	"[{""reference_id"": ""UniProtKB:P21524"", ""source_assertion"": ""UniProtKB:P21524 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/551/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P21524"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P21524 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_location-6f9e369e4d05_4bc692299a2a	UniProtKB:P09938	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09938	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12732713); ECO:0000269 (PubMed:18851834) Source qualification: Found predominantly in the nucleus under normal growth conditions and is redistributed to the cytoplasm in damaged cells in a DNA replication and damage checkpoint-dependent manner. Nuclear localization is mediated by DIF1	"[{""reference_id"": ""UniProtKB:P09938"", ""source_assertion"": ""UniProtKB:P09938 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/232/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P09938"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P09938 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_location-4e0ffac7dcc6_b26eb6d6a86a	UniProtKB:P49723	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P49723	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12732713); ECO:0000269 (PubMed:18851834) Source qualification: Found predominantly in the nucleus under normal growth conditions and is redistributed to the cytoplasm in damaged cells in a DNA replication and damage checkpoint-dependent manner. Nuclear localization is mediated by DIF1	"[{""reference_id"": ""UniProtKB:P49723"", ""source_assertion"": ""UniProtKB:P49723 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2032/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P49723"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P49723 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_location-4ac65d878989_8e14df46dfac	UniProtKB:P21672	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P21672	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12732713)	"[{""reference_id"": ""UniProtKB:P21672"", ""source_assertion"": ""UniProtKB:P21672 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/557/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P21672"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P21672 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_cofactor-857dafe2b77d_2f3133e73530	SGD:S000001550	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36010	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:5793714)	"[{""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1183/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 has the exact SGD cross-reference SGD:S000001550."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1183/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P36010"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36010 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7220-1_cofactor-c3fb132c513b_3a6d9717bc72	UniProtKB:P09938	pathwaymech:has_cofactor	CHEBI:24875	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09938	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified Binds 2 iron ions per subunit.	"[{""reference_id"": ""UniProtKB:P09938"", ""source_assertion"": ""UniProtKB:P09938 annotates CHEBI:24875 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/232/comments/0/cofactors/0; /results/232/comments/0/note""}]"	"[{""id"": ""UniProtKB:P09938"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P09938 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-001_6c4e19242034	CHEBI:456215	pathwaymech:consumes	RHEA:29376	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:29376		"[{""reference_id"": ""RHEA:29376"", ""source_assertion"": ""RHEA:29376 explicitly lists CHEBI:456215 as a substrate with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:29376 rh:substrates <http://rdf.rhea-db.org/29375_L>; <http://rdf.rhea-db.org/29375_L> rh:contains1 <http://rdf.rhea-db.org/Participant_29375_compound_2590>; <http://rdf.rhea-db.org/Participant_29375_compound_2590> rh:compound <http://rdf.rhea-db.org/Compound_2590> / rh:chebi""}]"	"[{""id"": ""RHEA:29376"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:29376"", ""url"": ""https://www.rhea-db.org/rhea/29376""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-002_6f90d55dd8db	CHEBI:15377	pathwaymech:consumes	RHEA:29376	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:29376		"[{""reference_id"": ""RHEA:29376"", ""source_assertion"": ""RHEA:29376 explicitly lists CHEBI:15377 as a substrate with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:29376 rh:substrates <http://rdf.rhea-db.org/29375_L>; <http://rdf.rhea-db.org/29375_L> rh:contains1 <http://rdf.rhea-db.org/Participant_29375_compound_1283>; <http://rdf.rhea-db.org/Participant_29375_compound_1283> rh:compound <http://rdf.rhea-db.org/Compound_1283> / rh:chebi""}]"	"[{""id"": ""RHEA:29376"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:29376"", ""url"": ""https://www.rhea-db.org/rhea/29376""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-003_d8eb369dae66	RHEA:29376	pathwaymech:produces	CHEBI:16335	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:29376		"[{""reference_id"": ""RHEA:29376"", ""source_assertion"": ""RHEA:29376 explicitly lists CHEBI:16335 as a product with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:29376 rh:products <http://rdf.rhea-db.org/29375_R>; <http://rdf.rhea-db.org/29375_R> rh:contains1 <http://rdf.rhea-db.org/Participant_29375_compound_2547>; <http://rdf.rhea-db.org/Participant_29375_compound_2547> rh:compound <http://rdf.rhea-db.org/Compound_2547> / rh:chebi""}]"	"[{""id"": ""RHEA:29376"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:29376"", ""url"": ""https://www.rhea-db.org/rhea/29376""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-004_22c73feb7b65	RHEA:29376	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:29376		"[{""reference_id"": ""RHEA:29376"", ""source_assertion"": ""RHEA:29376 explicitly lists CHEBI:43474 as a product with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:29376 rh:products <http://rdf.rhea-db.org/29375_R>; <http://rdf.rhea-db.org/29375_R> rh:contains1 <http://rdf.rhea-db.org/Participant_29375_compound_5518>; <http://rdf.rhea-db.org/Participant_29375_compound_5518> rh:compound <http://rdf.rhea-db.org/Compound_5518> / rh:chebi""}]"	"[{""id"": ""RHEA:29376"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:29376"", ""url"": ""https://www.rhea-db.org/rhea/29376""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-005_d41e3aa20e52	RHEA:29376	BFO:0000050	MetaCyc:SALVADEHYPOX-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:SALVADEHYPOX-PWY		"[{""reference_id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_assertion"": ""META 27.0 lists AMP-DEPHOSPHORYLATION-RXN among the complete five reactions of SALVADEHYPOX-PWY; its L2R layout matches this directional Rhea chemistry."", ""source_locator"": ""ptools-xml/Pathway[@frameid=\""SALVADEHYPOX-PWY\""]/reaction-list/Reaction[@frameid=\""AMP-DEPHOSPHORYLATION-RXN\""]; reaction-layout[Reaction/@frameid=\""AMP-DEPHOSPHORYLATION-RXN\""]""}]"	"[{""id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_sha256"": ""0754c4072e1f1aaf15f8320ab3b31ec1310e0f18f2e7417b7324853e46e8f0a0"", ""source_version"": ""Pathway Tools META PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""adenosine nucleotides degradation II"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:SALVADEHYPOX-PWY""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-006_6446fd4f17f6	CHEBI:16335	pathwaymech:consumes	RHEA:24409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24409		"[{""reference_id"": ""RHEA:24409"", ""source_assertion"": ""RHEA:24409 explicitly lists CHEBI:16335 as a substrate with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:substrates <http://rdf.rhea-db.org/24408_L>; <http://rdf.rhea-db.org/24408_L> rh:contains1 <http://rdf.rhea-db.org/Participant_24408_compound_2547>; <http://rdf.rhea-db.org/Participant_24408_compound_2547> rh:compound <http://rdf.rhea-db.org/Compound_2547> / rh:chebi""}]"	"[{""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:24409"", ""url"": ""https://www.rhea-db.org/rhea/24409""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-007_bfb12b9f3599	CHEBI:15377	pathwaymech:consumes	RHEA:24409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24409		"[{""reference_id"": ""RHEA:24409"", ""source_assertion"": ""RHEA:24409 explicitly lists CHEBI:15377 as a substrate with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:substrates <http://rdf.rhea-db.org/24408_L>; <http://rdf.rhea-db.org/24408_L> rh:contains1 <http://rdf.rhea-db.org/Participant_24408_compound_1283>; <http://rdf.rhea-db.org/Participant_24408_compound_1283> rh:compound <http://rdf.rhea-db.org/Compound_1283> / rh:chebi""}]"	"[{""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:24409"", ""url"": ""https://www.rhea-db.org/rhea/24409""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-008_f440d7e0ff11	CHEBI:15378	pathwaymech:consumes	RHEA:24409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24409		"[{""reference_id"": ""RHEA:24409"", ""source_assertion"": ""RHEA:24409 explicitly lists CHEBI:15378 as a substrate with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:substrates <http://rdf.rhea-db.org/24408_L>; <http://rdf.rhea-db.org/24408_L> rh:contains1 <http://rdf.rhea-db.org/Participant_24408_compound_3249>; <http://rdf.rhea-db.org/Participant_24408_compound_3249> rh:compound <http://rdf.rhea-db.org/Compound_3249> / rh:chebi""}]"	"[{""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:24409"", ""url"": ""https://www.rhea-db.org/rhea/24409""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-009_b5fc76cb4690	RHEA:24409	pathwaymech:produces	CHEBI:17596	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24409		"[{""reference_id"": ""RHEA:24409"", ""source_assertion"": ""RHEA:24409 explicitly lists CHEBI:17596 as a product with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:products <http://rdf.rhea-db.org/24408_R>; <http://rdf.rhea-db.org/24408_R> rh:contains1 <http://rdf.rhea-db.org/Participant_24408_compound_1231>; <http://rdf.rhea-db.org/Participant_24408_compound_1231> rh:compound <http://rdf.rhea-db.org/Compound_1231> / rh:chebi""}]"	"[{""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:24409"", ""url"": ""https://www.rhea-db.org/rhea/24409""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-010_59a6dd59081e	RHEA:24409	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24409		"[{""reference_id"": ""RHEA:24409"", ""source_assertion"": ""RHEA:24409 explicitly lists CHEBI:28938 as a product with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:24409 rh:products <http://rdf.rhea-db.org/24408_R>; <http://rdf.rhea-db.org/24408_R> rh:contains1 <http://rdf.rhea-db.org/Participant_24408_compound_1012>; <http://rdf.rhea-db.org/Participant_24408_compound_1012> rh:compound <http://rdf.rhea-db.org/Compound_1012> / rh:chebi""}]"	"[{""id"": ""RHEA:24409"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:24409"", ""url"": ""https://www.rhea-db.org/rhea/24409""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-011_362e403e9833	RHEA:24409	BFO:0000050	MetaCyc:SALVADEHYPOX-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:SALVADEHYPOX-PWY		"[{""reference_id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_assertion"": ""META 27.0 lists ADENODEAMIN-RXN among the complete five reactions of SALVADEHYPOX-PWY; its L2R layout matches this directional Rhea chemistry."", ""source_locator"": ""ptools-xml/Pathway[@frameid=\""SALVADEHYPOX-PWY\""]/reaction-list/Reaction[@frameid=\""ADENODEAMIN-RXN\""]; reaction-layout[Reaction/@frameid=\""ADENODEAMIN-RXN\""]""}]"	"[{""id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_sha256"": ""0754c4072e1f1aaf15f8320ab3b31ec1310e0f18f2e7417b7324853e46e8f0a0"", ""source_version"": ""Pathway Tools META PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""adenosine nucleotides degradation II"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:SALVADEHYPOX-PWY""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-012_b93b2cfc8f8f	CHEBI:17596	pathwaymech:consumes	RHEA:27647	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27647		"[{""reference_id"": ""RHEA:27647"", ""source_assertion"": ""RHEA:27647 explicitly lists CHEBI:17596 as a substrate with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:27647 rh:substrates <http://rdf.rhea-db.org/27646_L>; <http://rdf.rhea-db.org/27646_L> rh:contains1 <http://rdf.rhea-db.org/Participant_27646_compound_1231>; <http://rdf.rhea-db.org/Participant_27646_compound_1231> rh:compound <http://rdf.rhea-db.org/Compound_1231> / rh:chebi""}]"	"[{""id"": ""RHEA:27647"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:27647"", ""url"": ""https://www.rhea-db.org/rhea/27647""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-013_2ae643cb2a53	CHEBI:43474	pathwaymech:consumes	RHEA:27647	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27647		"[{""reference_id"": ""RHEA:27647"", ""source_assertion"": ""RHEA:27647 explicitly lists CHEBI:43474 as a substrate with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:27647 rh:substrates <http://rdf.rhea-db.org/27646_L>; <http://rdf.rhea-db.org/27646_L> rh:contains1 <http://rdf.rhea-db.org/Participant_27646_compound_5518>; <http://rdf.rhea-db.org/Participant_27646_compound_5518> rh:compound <http://rdf.rhea-db.org/Compound_5518> / rh:chebi""}]"	"[{""id"": ""RHEA:27647"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:27647"", ""url"": ""https://www.rhea-db.org/rhea/27647""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-014_db1e2e6b80b9	RHEA:27647	pathwaymech:produces	CHEBI:57720	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27647		"[{""reference_id"": ""RHEA:27647"", ""source_assertion"": ""RHEA:27647 explicitly lists CHEBI:57720 as a product with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:27647 rh:products <http://rdf.rhea-db.org/27646_R>; <http://rdf.rhea-db.org/27646_R> rh:contains1 <http://rdf.rhea-db.org/Participant_27646_compound_2276>; <http://rdf.rhea-db.org/Participant_27646_compound_2276> rh:compound <http://rdf.rhea-db.org/Compound_2276> / rh:chebi""}]"	"[{""id"": ""RHEA:27647"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:27647"", ""url"": ""https://www.rhea-db.org/rhea/27647""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-015_19c8b2004149	RHEA:27647	pathwaymech:produces	CHEBI:17368	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27647		"[{""reference_id"": ""RHEA:27647"", ""source_assertion"": ""RHEA:27647 explicitly lists CHEBI:17368 as a product with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:27647 rh:products <http://rdf.rhea-db.org/27646_R>; <http://rdf.rhea-db.org/27646_R> rh:contains1 <http://rdf.rhea-db.org/Participant_27646_compound_3881>; <http://rdf.rhea-db.org/Participant_27646_compound_3881> rh:compound <http://rdf.rhea-db.org/Compound_3881> / rh:chebi""}]"	"[{""id"": ""RHEA:27647"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:27647"", ""url"": ""https://www.rhea-db.org/rhea/27647""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-016_ebaac69d1380	RHEA:27647	BFO:0000050	MetaCyc:SALVADEHYPOX-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:SALVADEHYPOX-PWY	The native reaction record permits reversibility; the pathway layout selects L2R degradation. This directional Rhea node preserves that selected orientation, not irreversibility.	"[{""reference_id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_assertion"": ""META 27.0 lists INOPHOSPHOR-RXN among the complete five reactions of SALVADEHYPOX-PWY; its L2R layout matches this directional Rhea chemistry."", ""source_locator"": ""ptools-xml/Pathway[@frameid=\""SALVADEHYPOX-PWY\""]/reaction-list/Reaction[@frameid=\""INOPHOSPHOR-RXN\""]; reaction-layout[Reaction/@frameid=\""INOPHOSPHOR-RXN\""]""}]"	"[{""id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_sha256"": ""0754c4072e1f1aaf15f8320ab3b31ec1310e0f18f2e7417b7324853e46e8f0a0"", ""source_version"": ""Pathway Tools META PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""adenosine nucleotides degradation II"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:SALVADEHYPOX-PWY""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-017_e07fa5c9a997	CHEBI:17368	pathwaymech:consumes	RHEA:24671	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24671		"[{""reference_id"": ""RHEA:24671"", ""source_assertion"": ""RHEA:24671 explicitly lists CHEBI:17368 as a substrate with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:24671 rh:substrates <http://rdf.rhea-db.org/24670_L>; <http://rdf.rhea-db.org/24670_L> rh:contains1 <http://rdf.rhea-db.org/Participant_24670_compound_3881>; <http://rdf.rhea-db.org/Participant_24670_compound_3881> rh:compound <http://rdf.rhea-db.org/Compound_3881> / rh:chebi""}]"	"[{""id"": ""RHEA:24671"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:24671"", ""url"": ""https://www.rhea-db.org/rhea/24671""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-018_f84b46749703	CHEBI:57540	pathwaymech:consumes	RHEA:24671	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24671		"[{""reference_id"": ""RHEA:24671"", ""source_assertion"": ""RHEA:24671 explicitly lists CHEBI:57540 as a substrate with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:24671 rh:substrates <http://rdf.rhea-db.org/24670_L>; <http://rdf.rhea-db.org/24670_L> rh:contains1 <http://rdf.rhea-db.org/Participant_24670_compound_3484>; <http://rdf.rhea-db.org/Participant_24670_compound_3484> rh:compound <http://rdf.rhea-db.org/Compound_3484> / rh:chebi""}]"	"[{""id"": ""RHEA:24671"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:24671"", ""url"": ""https://www.rhea-db.org/rhea/24671""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-019_01ff43ef8d3b	CHEBI:15377	pathwaymech:consumes	RHEA:24671	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24671		"[{""reference_id"": ""RHEA:24671"", ""source_assertion"": ""RHEA:24671 explicitly lists CHEBI:15377 as a substrate with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:24671 rh:substrates <http://rdf.rhea-db.org/24670_L>; <http://rdf.rhea-db.org/24670_L> rh:contains1 <http://rdf.rhea-db.org/Participant_24670_compound_1283>; <http://rdf.rhea-db.org/Participant_24670_compound_1283> rh:compound <http://rdf.rhea-db.org/Compound_1283> / rh:chebi""}]"	"[{""id"": ""RHEA:24671"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:24671"", ""url"": ""https://www.rhea-db.org/rhea/24671""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-020_f226742e875a	RHEA:24671	pathwaymech:produces	CHEBI:17712	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24671		"[{""reference_id"": ""RHEA:24671"", ""source_assertion"": ""RHEA:24671 explicitly lists CHEBI:17712 as a product with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:24671 rh:products <http://rdf.rhea-db.org/24670_R>; <http://rdf.rhea-db.org/24670_R> rh:contains1 <http://rdf.rhea-db.org/Participant_24670_compound_3237>; <http://rdf.rhea-db.org/Participant_24670_compound_3237> rh:compound <http://rdf.rhea-db.org/Compound_3237> / rh:chebi""}]"	"[{""id"": ""RHEA:24671"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:24671"", ""url"": ""https://www.rhea-db.org/rhea/24671""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-021_7d712b74c6bd	RHEA:24671	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24671		"[{""reference_id"": ""RHEA:24671"", ""source_assertion"": ""RHEA:24671 explicitly lists CHEBI:57945 as a product with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:24671 rh:products <http://rdf.rhea-db.org/24670_R>; <http://rdf.rhea-db.org/24670_R> rh:contains1 <http://rdf.rhea-db.org/Participant_24670_compound_1650>; <http://rdf.rhea-db.org/Participant_24670_compound_1650> rh:compound <http://rdf.rhea-db.org/Compound_1650> / rh:chebi""}]"	"[{""id"": ""RHEA:24671"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:24671"", ""url"": ""https://www.rhea-db.org/rhea/24671""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-022_c252c1d28346	RHEA:24671	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24671		"[{""reference_id"": ""RHEA:24671"", ""source_assertion"": ""RHEA:24671 explicitly lists CHEBI:15378 as a product with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:24671 rh:products <http://rdf.rhea-db.org/24670_R>; <http://rdf.rhea-db.org/24670_R> rh:contains1 <http://rdf.rhea-db.org/Participant_24670_compound_3249>; <http://rdf.rhea-db.org/Participant_24670_compound_3249> rh:compound <http://rdf.rhea-db.org/Compound_3249> / rh:chebi""}]"	"[{""id"": ""RHEA:24671"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:24671"", ""url"": ""https://www.rhea-db.org/rhea/24671""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-023_c311ffe09fc7	RHEA:24671	BFO:0000050	MetaCyc:SALVADEHYPOX-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:SALVADEHYPOX-PWY		"[{""reference_id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_assertion"": ""META 27.0 lists RXN-7682 among the complete five reactions of SALVADEHYPOX-PWY; its L2R layout matches this directional Rhea chemistry."", ""source_locator"": ""ptools-xml/Pathway[@frameid=\""SALVADEHYPOX-PWY\""]/reaction-list/Reaction[@frameid=\""RXN-7682\""]; reaction-layout[Reaction/@frameid=\""RXN-7682\""]""}]"	"[{""id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_sha256"": ""0754c4072e1f1aaf15f8320ab3b31ec1310e0f18f2e7417b7324853e46e8f0a0"", ""source_version"": ""Pathway Tools META PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""adenosine nucleotides degradation II"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:SALVADEHYPOX-PWY""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-024_b3f25a4d4423	CHEBI:17712	pathwaymech:consumes	RHEA:16670	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16670		"[{""reference_id"": ""RHEA:16670"", ""source_assertion"": ""RHEA:16670 explicitly lists CHEBI:17712 as a substrate with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:16670 rh:substrates <http://rdf.rhea-db.org/16669_L>; <http://rdf.rhea-db.org/16669_L> rh:contains1 <http://rdf.rhea-db.org/Participant_16669_compound_3237>; <http://rdf.rhea-db.org/Participant_16669_compound_3237> rh:compound <http://rdf.rhea-db.org/Compound_3237> / rh:chebi""}]"	"[{""id"": ""RHEA:16670"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:16670"", ""url"": ""https://www.rhea-db.org/rhea/16670""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-025_3b9fd1cf982a	CHEBI:57540	pathwaymech:consumes	RHEA:16670	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16670		"[{""reference_id"": ""RHEA:16670"", ""source_assertion"": ""RHEA:16670 explicitly lists CHEBI:57540 as a substrate with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:16670 rh:substrates <http://rdf.rhea-db.org/16669_L>; <http://rdf.rhea-db.org/16669_L> rh:contains1 <http://rdf.rhea-db.org/Participant_16669_compound_3484>; <http://rdf.rhea-db.org/Participant_16669_compound_3484> rh:compound <http://rdf.rhea-db.org/Compound_3484> / rh:chebi""}]"	"[{""id"": ""RHEA:16670"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:16670"", ""url"": ""https://www.rhea-db.org/rhea/16670""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-026_4847224d87e6	CHEBI:15377	pathwaymech:consumes	RHEA:16670	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16670		"[{""reference_id"": ""RHEA:16670"", ""source_assertion"": ""RHEA:16670 explicitly lists CHEBI:15377 as a substrate with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:16670 rh:substrates <http://rdf.rhea-db.org/16669_L>; <http://rdf.rhea-db.org/16669_L> rh:contains1 <http://rdf.rhea-db.org/Participant_16669_compound_1283>; <http://rdf.rhea-db.org/Participant_16669_compound_1283> rh:compound <http://rdf.rhea-db.org/Compound_1283> / rh:chebi""}]"	"[{""id"": ""RHEA:16670"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:16670"", ""url"": ""https://www.rhea-db.org/rhea/16670""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-027_3180ebc63648	RHEA:16670	pathwaymech:produces	CHEBI:17775	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16670		"[{""reference_id"": ""RHEA:16670"", ""source_assertion"": ""RHEA:16670 explicitly lists CHEBI:17775 as a product with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:16670 rh:products <http://rdf.rhea-db.org/16669_R>; <http://rdf.rhea-db.org/16669_R> rh:contains1 <http://rdf.rhea-db.org/Participant_16669_compound_6691>; <http://rdf.rhea-db.org/Participant_16669_compound_6691> rh:compound <http://rdf.rhea-db.org/Compound_6691> / rh:chebi""}]"	"[{""id"": ""RHEA:16670"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:16670"", ""url"": ""https://www.rhea-db.org/rhea/16670""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-028_22310451611a	RHEA:16670	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16670		"[{""reference_id"": ""RHEA:16670"", ""source_assertion"": ""RHEA:16670 explicitly lists CHEBI:57945 as a product with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:16670 rh:products <http://rdf.rhea-db.org/16669_R>; <http://rdf.rhea-db.org/16669_R> rh:contains1 <http://rdf.rhea-db.org/Participant_16669_compound_1650>; <http://rdf.rhea-db.org/Participant_16669_compound_1650> rh:compound <http://rdf.rhea-db.org/Compound_1650> / rh:chebi""}]"	"[{""id"": ""RHEA:16670"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:16670"", ""url"": ""https://www.rhea-db.org/rhea/16670""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-029_94b0f122161e	RHEA:16670	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16670		"[{""reference_id"": ""RHEA:16670"", ""source_assertion"": ""RHEA:16670 explicitly lists CHEBI:15378 as a product with coefficient 1; its linked Rhea formula and charge agree with the bound ChEBI 255 identity."", ""source_locator"": ""rhea.rdf.gz; rh:16670 rh:products <http://rdf.rhea-db.org/16669_R>; <http://rdf.rhea-db.org/16669_R> rh:contains1 <http://rdf.rhea-db.org/Participant_16669_compound_3249>; <http://rdf.rhea-db.org/Participant_16669_compound_3249> rh:compound <http://rdf.rhea-db.org/Compound_3249> / rh:chebi""}]"	"[{""id"": ""RHEA:16670"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release 2026-09-02; retained complete original RDF retrieved 2026-10-10"", ""title"": ""Rhea directional reaction RHEA:16670"", ""url"": ""https://www.rhea-db.org/rhea/16670""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-030_af519ca5a8fb	RHEA:16670	BFO:0000050	MetaCyc:SALVADEHYPOX-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:SALVADEHYPOX-PWY	The native reaction record permits reversibility; the pathway layout selects L2R degradation. This directional Rhea node preserves that selected orientation, not irreversibility.	"[{""reference_id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_assertion"": ""META 27.0 lists RXN0-901 among the complete five reactions of SALVADEHYPOX-PWY; its L2R layout matches this directional Rhea chemistry."", ""source_locator"": ""ptools-xml/Pathway[@frameid=\""SALVADEHYPOX-PWY\""]/reaction-list/Reaction[@frameid=\""RXN0-901\""]; reaction-layout[Reaction/@frameid=\""RXN0-901\""]""}]"	"[{""id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_sha256"": ""0754c4072e1f1aaf15f8320ab3b31ec1310e0f18f2e7417b7324853e46e8f0a0"", ""source_version"": ""Pathway Tools META PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""adenosine nucleotides degradation II"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:SALVADEHYPOX-PWY""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-031_7631bcc11fb9	RHEA:29376	RO:0002413	RHEA:24409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:SALVADEHYPOX-PWY	Material continuity in the defined pathway. This is not an added membrane-transport reaction or a claim that every alternative enzyme shares a compartment.	"[{""reference_id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_assertion"": ""The native predecessor relation orders AMP-DEPHOSPHORYLATION-RXN before ADENODEAMIN-RXN; the pathway layouts share the intervening named metabolite."", ""source_locator"": ""ptools-xml/Pathway/reaction-ordering/Reaction[@frameid=\""ADENODEAMIN-RXN\""] with predecessor-reactions/Reaction[@frameid=\""AMP-DEPHOSPHORYLATION-RXN\""]""}]"	"[{""id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_sha256"": ""0754c4072e1f1aaf15f8320ab3b31ec1310e0f18f2e7417b7324853e46e8f0a0"", ""source_version"": ""Pathway Tools META PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""adenosine nucleotides degradation II"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:SALVADEHYPOX-PWY""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-032_e51cd7ff07c1	RHEA:24409	RO:0002413	RHEA:27647	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:SALVADEHYPOX-PWY	Material continuity in the defined pathway. This is not an added membrane-transport reaction or a claim that every alternative enzyme shares a compartment.	"[{""reference_id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_assertion"": ""The native predecessor relation orders ADENODEAMIN-RXN before INOPHOSPHOR-RXN; the pathway layouts share the intervening named metabolite."", ""source_locator"": ""ptools-xml/Pathway/reaction-ordering/Reaction[@frameid=\""INOPHOSPHOR-RXN\""] with predecessor-reactions/Reaction[@frameid=\""ADENODEAMIN-RXN\""]""}]"	"[{""id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_sha256"": ""0754c4072e1f1aaf15f8320ab3b31ec1310e0f18f2e7417b7324853e46e8f0a0"", ""source_version"": ""Pathway Tools META PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""adenosine nucleotides degradation II"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:SALVADEHYPOX-PWY""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-033_5e22c11fd1f8	RHEA:27647	RO:0002413	RHEA:24671	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:SALVADEHYPOX-PWY	Material continuity in the defined pathway. This is not an added membrane-transport reaction or a claim that every alternative enzyme shares a compartment.	"[{""reference_id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_assertion"": ""The native predecessor relation orders INOPHOSPHOR-RXN before RXN-7682; the pathway layouts share the intervening named metabolite."", ""source_locator"": ""ptools-xml/Pathway/reaction-ordering/Reaction[@frameid=\""RXN-7682\""] with predecessor-reactions/Reaction[@frameid=\""INOPHOSPHOR-RXN\""]""}]"	"[{""id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_sha256"": ""0754c4072e1f1aaf15f8320ab3b31ec1310e0f18f2e7417b7324853e46e8f0a0"", ""source_version"": ""Pathway Tools META PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""adenosine nucleotides degradation II"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:SALVADEHYPOX-PWY""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-034_3ccc8249d0d4	RHEA:24671	RO:0002413	RHEA:16670	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:SALVADEHYPOX-PWY	Material continuity in the defined pathway. This is not an added membrane-transport reaction or a claim that every alternative enzyme shares a compartment.	"[{""reference_id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_assertion"": ""The native predecessor relation orders RXN-7682 before RXN0-901; the pathway layouts share the intervening named metabolite."", ""source_locator"": ""ptools-xml/Pathway/reaction-ordering/Reaction[@frameid=\""RXN0-901\""] with predecessor-reactions/Reaction[@frameid=\""RXN-7682\""]""}]"	"[{""id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_sha256"": ""0754c4072e1f1aaf15f8320ab3b31ec1310e0f18f2e7417b7324853e46e8f0a0"", ""source_version"": ""Pathway Tools META PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""adenosine nucleotides degradation II"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:SALVADEHYPOX-PWY""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-035_071dde0becde	RHEA:16670	RO:0002413	MetaCyc:PWY-5691	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:URATE|MetaCyc:SALVADEHYPOX-PWY	Opaque, source-scoped META urate-conversion interface. The ECOLI definition omits this link; this edge does not assign the oxidative downstream pathway to MG1655.	"[{""reference_id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_assertion"": ""META 27.0 links pathway output URATE to PWY-5691. The link is a downstream pathway interface, not membership of its three reactions."", ""source_locator"": ""ptools-xml/Pathway/pathway-link[Compound/@frameid=\""URATE\""]/link-target/Pathway[@frameid=\""PWY-5691\""]""}, {""reference_id"": ""EcoCyc:URATE"", ""source_assertion"": ""The native URATE compound links ChEBI 17775, the formal neutral species used for the Rhea urate-labelled product. This mapping does not add an E. coli downstream urate pathway."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""URATE\""]/dblink[dblink-db=\""CHEBI\""]/dblink-oid""}]"	"[{""id"": ""EcoCyc:URATE"", ""source_sha256"": ""9f33ed8d7eed9e2b6776b6e964e0518b8db84e0b6950331112a7c26e213b9a8c"", ""source_version"": ""ECOLI 27.0; retrieved 2026-10-11"", ""title"": ""URATE native chemical identity"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:URATE""}, {""id"": ""MetaCyc:SALVADEHYPOX-PWY"", ""source_sha256"": ""0754c4072e1f1aaf15f8320ab3b31ec1310e0f18f2e7417b7324853e46e8f0a0"", ""source_version"": ""Pathway Tools META PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""adenosine nucleotides degradation II"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:SALVADEHYPOX-PWY""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-036_f2c93529e47a	UniProtKB:P00634	BFO:0000050	EcoCyc:ALKAPHOSPHA-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:ALKAPHOSPHA-CPLX|UniProtKB:P00634	Native assembly, not a mixed phosphatase heteromer.	"[{""reference_id"": ""EcoCyc:ALKAPHOSPHA-CPLX"", ""source_assertion"": ""The native ECOLI assembly contains 2 copies of ALKAPHOSPHA-MONOMER."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""ALKAPHOSPHA-CPLX\""]/component[Protein/@frameid=\""ALKAPHOSPHA-MONOMER\""]/coefficient""}, {""reference_id"": ""UniProtKB:P00634"", ""source_assertion"": ""The issuing reviewed protein entry has an explicit BioCyc cross-reference to EcoCyc:ALKAPHOSPHA-MONOMER."", ""source_locator"": ""$.uniProtKBCrossReferences[database=\""BioCyc\"",id=\""EcoCyc:ALKAPHOSPHA-MONOMER\""]""}]"	"[{""id"": ""EcoCyc:ALKAPHOSPHA-CPLX"", ""source_sha256"": ""916ee5e2a9972e2d51d99cb194ec8f86c314f6abba083b12037ca36793aa8e1e"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""alkaline phosphatase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:ALKAPHOSPHA-CPLX""}, {""id"": ""UniProtKB:P00634"", ""source_sha256"": ""3daf839ecfe721bb781dc3f569c692923808cb6cc60a6b8f1ded7a98a528f7c8"", ""source_version"": ""UniProt reviewed entry version 230, sequence version 1; updated 2026-09-02"", ""title"": ""Alkaline phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00634.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-037_f5e7b024c2ce	UniProtKB:P0AE22	BFO:0000050	EcoCyc:APHA-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:APHA-CPLX|UniProtKB:P0AE22	Native assembly, not a mixed phosphatase heteromer.	"[{""reference_id"": ""EcoCyc:APHA-CPLX"", ""source_assertion"": ""The native ECOLI assembly contains 4 copies of APHA-MONOMER."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""APHA-CPLX\""]/component[Protein/@frameid=\""APHA-MONOMER\""]/coefficient""}, {""reference_id"": ""UniProtKB:P0AE22"", ""source_assertion"": ""The issuing reviewed protein entry has an explicit BioCyc cross-reference to EcoCyc:APHA-MONOMER."", ""source_locator"": ""$.uniProtKBCrossReferences[database=\""BioCyc\"",id=\""EcoCyc:APHA-MONOMER\""]""}]"	"[{""id"": ""EcoCyc:APHA-CPLX"", ""source_sha256"": ""32fd5772b44b5e2eb8e3d26d2dca3aaf1ac05a750391d890249c29f9259f09be"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""acid phosphatase / phosphotransferase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:APHA-CPLX""}, {""id"": ""UniProtKB:P0AE22"", ""source_sha256"": ""36c63e459953942cf2363627809b4bd79c7e582965ebaf73596be84b5aa745b1"", ""source_version"": ""UniProt reviewed entry version 147, sequence version 1; updated 2026-06-10"", ""title"": ""Class B acid phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AE22.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-038_370e127c11fc	UniProtKB:P0ABP8	BFO:0000050	EcoCyc:DEOD-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:DEOD-CPLX|UniProtKB:P0ABP8	Native assembly, not a mixed phosphatase heteromer.	"[{""reference_id"": ""EcoCyc:DEOD-CPLX"", ""source_assertion"": ""The native ECOLI assembly contains 6 copies of DEOD-MONOMER."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""DEOD-CPLX\""]/component[Protein/@frameid=\""DEOD-MONOMER\""]/coefficient""}, {""reference_id"": ""UniProtKB:P0ABP8"", ""source_assertion"": ""The issuing reviewed protein entry has an explicit BioCyc cross-reference to EcoCyc:DEOD-MONOMER."", ""source_locator"": ""$.uniProtKBCrossReferences[database=\""BioCyc\"",id=\""EcoCyc:DEOD-MONOMER\""]""}]"	"[{""id"": ""EcoCyc:DEOD-CPLX"", ""source_sha256"": ""87ab3e0bda1204524ecaac08b36b83b254c9b976c829585797b72ea82d508b15"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""purine nucleoside phosphorylase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:DEOD-CPLX""}, {""id"": ""UniProtKB:P0ABP8"", ""source_sha256"": ""261a1c1e34fcc0af42d3a3b4a16c27a01ecba13eee2437d3f4d8c51e422eed02"", ""source_version"": ""UniProt reviewed entry version 149, sequence version 2; updated 2026-09-02"", ""title"": ""Purine nucleoside phosphorylase DeoD-type"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABP8.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-039_d20c0d30e784	UniProtKB:P45563	BFO:0000050	EcoCyc:XANTHOSINEPHOSPHORY-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:XANTHOSINEPHOSPHORY-CPLX|UniProtKB:P45563	Native assembly representation; XapA also has reported trimer coexistence, and this hexamer is not every preparation.	"[{""reference_id"": ""EcoCyc:XANTHOSINEPHOSPHORY-CPLX"", ""source_assertion"": ""The native ECOLI assembly contains 6 copies of XANTHOSINEPHOSPHORY-MONOMER."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""XANTHOSINEPHOSPHORY-CPLX\""]/component[Protein/@frameid=\""XANTHOSINEPHOSPHORY-MONOMER\""]/coefficient""}, {""reference_id"": ""UniProtKB:P45563"", ""source_assertion"": ""The issuing reviewed protein entry has an explicit BioCyc cross-reference to EcoCyc:XANTHOSINEPHOSPHORY-MONOMER."", ""source_locator"": ""$.uniProtKBCrossReferences[database=\""BioCyc\"",id=\""EcoCyc:XANTHOSINEPHOSPHORY-MONOMER\""]""}]"	"[{""id"": ""EcoCyc:XANTHOSINEPHOSPHORY-CPLX"", ""source_sha256"": ""c3c783992924430cb6361b771d83ef92cd4fdefb3b7eca3adfc72e61a9929d0a"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""xanthosine phosphorylase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:XANTHOSINEPHOSPHORY-CPLX""}, {""id"": ""UniProtKB:P45563"", ""source_sha256"": ""eec50a639f7798e4b2aff2b3319ffd797a9e47806646ef8c15ab0339156f6fd1"", ""source_version"": ""UniProt reviewed entry version 176, sequence version 2; updated 2026-09-02"", ""title"": ""Purine nucleoside phosphorylase 2"", ""url"": ""https://rest.uniprot.org/uniprotkb/P45563.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-040_c2135dee4795	UniProtKB:P0C037	BFO:0000050	EcoCyc:CPLX0-8619	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-8619|UniProtKB:P0C037	Native assembly, not a mixed phosphatase heteromer.	"[{""reference_id"": ""EcoCyc:CPLX0-8619"", ""source_assertion"": ""The native ECOLI assembly contains 2 copies of EG12159-MONOMER."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""CPLX0-8619\""]/component[Protein/@frameid=\""EG12159-MONOMER\""]/coefficient""}, {""reference_id"": ""UniProtKB:P0C037"", ""source_assertion"": ""The issuing reviewed protein entry has an explicit BioCyc cross-reference to EcoCyc:EG12159-MONOMER."", ""source_locator"": ""$.uniProtKBCrossReferences[database=\""BioCyc\"",id=\""EcoCyc:EG12159-MONOMER\""]""}]"	"[{""id"": ""EcoCyc:CPLX0-8619"", ""source_sha256"": ""fe64bf4d3bc222247bfd0b7feb412bdc81a95b9f822f8931b1e62227f8abb9e3"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""nucleoside phosphorylase PpnP"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:CPLX0-8619""}, {""id"": ""UniProtKB:P0C037"", ""source_sha256"": ""01548b1e3468c516ccabfcde565b6ed539b90004bf11a5829d287399115a72ee"", ""source_version"": ""UniProt reviewed entry version 125, sequence version 1; updated 2026-09-02"", ""title"": ""Pyrimidine/purine nucleoside phosphorylase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0C037.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-041_6cd473c811e0	UniProtKB:Q46799	BFO:0000050	EcoCyc:CPLX0-761	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-761|UniProtKB:Q46799	Putative complex composition; no exact native coefficient asserted.	"[{""reference_id"": ""EcoCyc:CPLX0-761"", ""source_assertion"": ""The native putative xanthine dehydrogenase includes G7485-MONOMER without an explicit component coefficient; this does not establish measured stoichiometry."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""CPLX0-761\""]/component[Protein/@frameid=\""G7485-MONOMER\""]""}, {""reference_id"": ""UniProtKB:Q46799"", ""source_assertion"": ""The reviewed protein maps to native EcoCyc:G7485-MONOMER; the heterotrimer annotation is inferred, not a purified assembly measurement."", ""source_locator"": ""$.uniProtKBCrossReferences; $.comments[commentType=\""SUBUNIT\""]""}]"	"[{""id"": ""EcoCyc:CPLX0-761"", ""source_sha256"": ""fc615b976598946853d367ee13910521bf13ae45418da38fe93b4f8c838e7b0a"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""putative xanthine dehydrogenase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:CPLX0-761""}, {""id"": ""UniProtKB:Q46799"", ""source_sha256"": ""35d34f53a060da18cfb01792a8f039232b7f068a2fbd04bacb3437851c543d75"", ""source_version"": ""UniProt reviewed entry version 165, sequence version 1; updated 2026-09-02"", ""title"": ""Putative xanthine dehydrogenase molybdenum-binding subunit XdhA"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q46799.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-042_b84708a09487	UniProtKB:Q46800	BFO:0000050	EcoCyc:CPLX0-761	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-761|UniProtKB:Q46800	Putative complex composition; no exact native coefficient asserted.	"[{""reference_id"": ""EcoCyc:CPLX0-761"", ""source_assertion"": ""The native putative xanthine dehydrogenase includes G7486-MONOMER without an explicit component coefficient; this does not establish measured stoichiometry."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""CPLX0-761\""]/component[Protein/@frameid=\""G7486-MONOMER\""]""}, {""reference_id"": ""UniProtKB:Q46800"", ""source_assertion"": ""The reviewed protein maps to native EcoCyc:G7486-MONOMER; the heterotrimer annotation is inferred, not a purified assembly measurement."", ""source_locator"": ""$.uniProtKBCrossReferences; $.comments[commentType=\""SUBUNIT\""]""}]"	"[{""id"": ""EcoCyc:CPLX0-761"", ""source_sha256"": ""fc615b976598946853d367ee13910521bf13ae45418da38fe93b4f8c838e7b0a"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""putative xanthine dehydrogenase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:CPLX0-761""}, {""id"": ""UniProtKB:Q46800"", ""source_sha256"": ""954cd16047afaff7ff02b25945af846565bf32500625ebe892c4c089587de7ce"", ""source_version"": ""UniProt reviewed entry version 160, sequence version 1; updated 2026-09-02"", ""title"": ""Putative xanthine dehydrogenase FAD-binding subunit XdhB"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q46800.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-043_c3c92f111870	UniProtKB:Q46801	BFO:0000050	EcoCyc:CPLX0-761	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-761|UniProtKB:Q46801	Putative complex composition; no exact native coefficient asserted.	"[{""reference_id"": ""EcoCyc:CPLX0-761"", ""source_assertion"": ""The native putative xanthine dehydrogenase includes G7487-MONOMER without an explicit component coefficient; this does not establish measured stoichiometry."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""CPLX0-761\""]/component[Protein/@frameid=\""G7487-MONOMER\""]""}, {""reference_id"": ""UniProtKB:Q46801"", ""source_assertion"": ""The reviewed protein maps to native EcoCyc:G7487-MONOMER; the heterotrimer annotation is inferred, not a purified assembly measurement."", ""source_locator"": ""$.uniProtKBCrossReferences; $.comments[commentType=\""SUBUNIT\""]""}]"	"[{""id"": ""EcoCyc:CPLX0-761"", ""source_sha256"": ""fc615b976598946853d367ee13910521bf13ae45418da38fe93b4f8c838e7b0a"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""putative xanthine dehydrogenase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:CPLX0-761""}, {""id"": ""UniProtKB:Q46801"", ""source_sha256"": ""84c65b9d56b3b308ce34d379e7831683e6df814acee1fea094244781317efb33"", ""source_version"": ""UniProt reviewed entry version 163, sequence version 1; updated 2026-09-02"", ""title"": ""Putative xanthine dehydrogenase iron-sulfur-binding subunit XdhC"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q46801.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-044_b8ae37cecf69	EcoCyc:ALKAPHOSPHA-CPLX	pathwaymech:catalyzes	RHEA:29376	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:AMP-DEPHOSPHORYLATION-RXN	Periplasmic PhoA alternative; not an assembly with UshA or AphA.	"[{""reference_id"": ""EcoCyc:AMP-DEPHOSPHORYLATION-RXN"", ""source_assertion"": ""ENZRXN0-7738 explicitly assigns ALKAPHOSPHA-CPLX to AMP-DEPHOSPHORYLATION-RXN in ECOLI 27.0."", ""source_locator"": ""ptools-xml/Reaction/enzymatic-reaction/Enzymatic-Reaction[@frameid=\""ENZRXN0-7738\""]""}]"	"[{""id"": ""EcoCyc:AMP-DEPHOSPHORYLATION-RXN"", ""source_sha256"": ""7099f6f5dca176d04861aab1a59f42378683f9c90ba9a4b45bc816ae0f883497"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""EcoCyc:AMP-DEPHOSPHORYLATION-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:AMP-DEPHOSPHORYLATION-RXN""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-045_420d6dc5f8bf	UniProtKB:P07024	pathwaymech:catalyzes	RHEA:29376	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:USHA-MONOMER	Source-qualified nucleotidase alternative. Periplasmic and intracellular possibilities are not joined by an invented transporter.	"[{""reference_id"": ""EcoCyc:USHA-MONOMER"", ""source_assertion"": ""Native UshA is a broad 5-prime ribonucleotidase; ushA aphA double knockout blocks purine-nucleotide carbon utilization. AMP hydrolysis is retained as the annotated alternative, not proof of dominant intracellular flux."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""USHA-MONOMER\""]/comment""}]"	"[{""id"": ""EcoCyc:USHA-MONOMER"", ""source_sha256"": ""239d0f9257e969663cd54d62f0e58eaa872462d059f55ed037f722eb45d8e6b4"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""5'-nucleotidase / UDP-sugar hydrolase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:USHA-MONOMER""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-046_6ff3717d26ef	UniProtKB:P0AF24	pathwaymech:catalyzes	RHEA:29376	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:EG10634-MONOMER	Source-qualified nucleotidase alternative. Periplasmic and intracellular possibilities are not joined by an invented transporter.	"[{""reference_id"": ""EcoCyc:EG10634-MONOMER"", ""source_assertion"": ""The native UmpH comment explicitly lists AMP among its effective phosphatase substrates. This broad-specificity alternative does not establish its dominant physiological substrate."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""EG10634-MONOMER\""]/comment""}]"	"[{""id"": ""EcoCyc:EG10634-MONOMER"", ""source_sha256"": ""a223542da2c93c10418900471196c04ed4614356347b363192e4577a83670790"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""UMP phosphatase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:EG10634-MONOMER""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-047_b1425a1e72aa	UniProtKB:P0A840	pathwaymech:catalyzes	RHEA:29376	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:EG11817-MONOMER	Source-qualified nucleotidase alternative. Periplasmic and intracellular possibilities are not joined by an invented transporter.	"[{""reference_id"": ""EcoCyc:EG11817-MONOMER"", ""source_assertion"": ""The native UmpG comment explicitly lists 5-prime AMP among high-affinity substrates, with divalent-metal-dependent phosphatase activity. No exact oligomer stoichiometry is assigned."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""EG11817-MONOMER\""]/comment""}]"	"[{""id"": ""EcoCyc:EG11817-MONOMER"", ""source_sha256"": ""628b1b274774bdbe5d20382a18a3a583f8af289dc08c4b603d907464ab689c4f"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""broad specificity 5'(3')-nucleotidase and polyphosphatase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:EG11817-MONOMER""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-048_16021149e845	EcoCyc:APHA-CPLX	pathwaymech:catalyzes	RHEA:29376	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:APHA-CPLX|UniProtKB:P0AE22	Periplasmic broad-specificity AphA homotetramer alternative; neither a mixed phosphatase complex nor an assertion of uniquely dominant AMP flux.	"[{""reference_id"": ""UniProtKB:P0AE22"", ""source_assertion"": ""Reviewed AphA dephosphorylates 3-prime and 5-prime nucleotides, including the AMP substrate class. This is a broad-specificity alternative, without a claim of uniquely dominant physiological AMP flux."", ""source_locator"": ""$.comments[0] (FUNCTION)""}, {""reference_id"": ""EcoCyc:APHA-CPLX"", ""source_assertion"": ""APHA-CPLX catalyzes the generic nucleoside 5-prime-monophosphate phosphatase reaction 5-NUCLEOTID-RXN via ENZRXN0-7768."", ""source_locator"": ""ptools-xml/Protein/catalyzes/Enzymatic-Reaction[@frameid=\""ENZRXN0-7768\""]/reaction""}]"	"[{""id"": ""EcoCyc:APHA-CPLX"", ""source_sha256"": ""32fd5772b44b5e2eb8e3d26d2dca3aaf1ac05a750391d890249c29f9259f09be"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""acid phosphatase / phosphotransferase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:APHA-CPLX""}, {""id"": ""UniProtKB:P0AE22"", ""source_sha256"": ""36c63e459953942cf2363627809b4bd79c7e582965ebaf73596be84b5aa745b1"", ""source_version"": ""UniProt reviewed entry version 147, sequence version 1; updated 2026-06-10"", ""title"": ""Class B acid phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AE22.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-049_430b83c10a2b	UniProtKB:P22333	pathwaymech:catalyzes	RHEA:24409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P22333		"[{""reference_id"": ""UniProtKB:P22333"", ""source_assertion"": ""The reviewed Add entry assigns adenosine hydrolytic deamination to RHEA:24408 and cites experimental and HAMAP inference annotations."", ""source_locator"": ""$.comments[commentType=\""CATALYTIC ACTIVITY\""]/reaction[reactionCrossReferences/id=\""RHEA:24408\""]""}]"	"[{""id"": ""UniProtKB:P22333"", ""source_sha256"": ""23e32e2f4a9fc0b04d71ef7ccef5441c01b1b100951453b1f47d623fe4782181"", ""source_version"": ""UniProt reviewed entry version 183, sequence version 2; updated 2026-09-02"", ""title"": ""Adenosine deaminase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P22333.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-050_074934526ec0	EcoCyc:DEOD-CPLX	pathwaymech:catalyzes	RHEA:27647	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:DEOD-CPLX	Alternative inosine phosphorylase; pathway direction does not deny reversibility.	"[{""reference_id"": ""EcoCyc:DEOD-CPLX"", ""source_assertion"": ""Native INOPHOSPHOR-ENZRXN assigns this assembly to INOPHOSPHOR-RXN, inosine phosphorolysis. The reversible reaction is oriented toward hypoxanthine in this degradation route."", ""source_locator"": ""ptools-xml/Protein/catalyzes/Enzymatic-Reaction[@frameid=\""INOPHOSPHOR-ENZRXN\""]/reaction""}]"	"[{""id"": ""EcoCyc:DEOD-CPLX"", ""source_sha256"": ""87ab3e0bda1204524ecaac08b36b83b254c9b976c829585797b72ea82d508b15"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""purine nucleoside phosphorylase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:DEOD-CPLX""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-051_cf62e4521a4e	EcoCyc:XANTHOSINEPHOSPHORY-CPLX	pathwaymech:catalyzes	RHEA:27647	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:XANTHOSINEPHOSPHORY-CPLX	Alternative inosine phosphorylase; pathway direction does not deny reversibility.	"[{""reference_id"": ""EcoCyc:XANTHOSINEPHOSPHORY-CPLX"", ""source_assertion"": ""Native ENZRXN0-7335 assigns this assembly to INOPHOSPHOR-RXN, inosine phosphorolysis. The reversible reaction is oriented toward hypoxanthine in this degradation route."", ""source_locator"": ""ptools-xml/Protein/catalyzes/Enzymatic-Reaction[@frameid=\""ENZRXN0-7335\""]/reaction""}]"	"[{""id"": ""EcoCyc:XANTHOSINEPHOSPHORY-CPLX"", ""source_sha256"": ""c3c783992924430cb6361b771d83ef92cd4fdefb3b7eca3adfc72e61a9929d0a"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""xanthosine phosphorylase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:XANTHOSINEPHOSPHORY-CPLX""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-052_adb8345776e8	EcoCyc:CPLX0-8619	pathwaymech:catalyzes	RHEA:27647	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-8619	Alternative inosine phosphorylase; pathway direction does not deny reversibility.	"[{""reference_id"": ""EcoCyc:CPLX0-8619"", ""source_assertion"": ""Native ENZRXN0-8336 assigns this assembly to INOPHOSPHOR-RXN, inosine phosphorolysis. The reversible reaction is oriented toward hypoxanthine in this degradation route."", ""source_locator"": ""ptools-xml/Protein/catalyzes/Enzymatic-Reaction[@frameid=\""ENZRXN0-8336\""]/reaction""}]"	"[{""id"": ""EcoCyc:CPLX0-8619"", ""source_sha256"": ""fe64bf4d3bc222247bfd0b7feb412bdc81a95b9f822f8931b1e62227f8abb9e3"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""nucleoside phosphorylase PpnP"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:CPLX0-8619""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-053_d2770dd5e3a3	EcoCyc:CPLX0-761	pathwaymech:enables	RHEA:24671	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-761|PMID:10986234	Putative/inferred NAD-linked XdhABC activity. Genetic evidence supports involvement in xanthine consumption; exact electron-acceptor preference and purified cofactor occupancy remain unmeasured here.	"[{""reference_id"": ""EcoCyc:CPLX0-761"", ""source_assertion"": ""ECOLI 27.0 assigns the putative XdhABC complex to RXN-7682 via ENZRXN0-1061. This native NAD-linked annotation is not a direct purified-enzyme demonstration of NAD preference."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""CPLX0-761\""]/catalyzes/Enzymatic-Reaction[@frameid=\""ENZRXN0-1061\""]""}, {""reference_id"": ""PMID:10986234"", ""source_assertion"": ""In W3110 derivatives, xdhA genetics and radiolabel experiments support purine interconversion; the authors could not directly assay XDH/XO. The heterotrimer and NAD preference are not experimentally established by this work."", ""source_locator"": ""PMC110974 full HTML #sec14, #sec20""}]"	"[{""id"": ""EcoCyc:CPLX0-761"", ""source_sha256"": ""fc615b976598946853d367ee13910521bf13ae45418da38fe93b4f8c838e7b0a"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""putative xanthine dehydrogenase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:CPLX0-761""}, {""id"": ""PMID:10986234"", ""source_sha256"": ""ad7a93b05aea294569d88ad68116f9945c05fbd4f6add882a9bb12bee481dfdd"", ""source_version"": ""Original retrieved 2026-10-11; access scope retained in the evidence ledger"", ""title"": ""PMID:10986234"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC110974/""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-054_942fcdcdc99f	EcoCyc:CPLX0-761	pathwaymech:enables	RHEA:16670	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-761|PMID:41070194	Putative/inferred NAD-linked XdhABC activity. Genetic evidence supports involvement in xanthine consumption; exact electron-acceptor preference and purified cofactor occupancy remain unmeasured here.	"[{""reference_id"": ""EcoCyc:CPLX0-761"", ""source_assertion"": ""ECOLI 27.0 assigns the putative XdhABC complex to RXN0-901 via ENZRXN0-1062. This native NAD-linked annotation is not a direct purified-enzyme demonstration of NAD preference."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""CPLX0-761\""]/catalyzes/Enzymatic-Reaction[@frameid=\""ENZRXN0-1062\""]""}, {""reference_id"": ""PMID:41070194"", ""source_assertion"": ""In anaerobic MG1655 M9 glucose cultures, deletion of xdhA abolished xanthine consumption; deletion of xdhD allowed consumption with urate accumulation. This supports XdhA-linked oxidation, without measuring purified XdhABC NAD preference."", ""source_locator"": ""PMC12507026 full HTML #s8 Fig4b-c and #s14""}]"	"[{""id"": ""EcoCyc:CPLX0-761"", ""source_sha256"": ""fc615b976598946853d367ee13910521bf13ae45418da38fe93b4f8c838e7b0a"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""putative xanthine dehydrogenase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:CPLX0-761""}, {""id"": ""PMID:41070194"", ""source_sha256"": ""6fa3137490ad04fedf640112f92af629f97baee418819c0f5ace1b66d15e2838"", ""source_version"": ""Original retrieved 2026-10-11; access scope retained in the evidence ledger"", ""title"": ""PMID:41070194"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC12507026/""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-055_03d55060a582	UniProtKB:P00634	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00634	Binds 1 Mg(2+) ion.	"[{""reference_id"": ""UniProtKB:P00634"", ""source_assertion"": ""Reviewed annotation. UniProtKB:P00634 has the annotated cofactor Mg(2+). Binds 1 Mg(2+) ion."", ""source_locator"": ""JSON Pointer /comments/1; cofactor identity /comments/1/cofactors/0/cofactorCrossReference/id""}]"	"[{""id"": ""UniProtKB:P00634"", ""source_sha256"": ""3daf839ecfe721bb781dc3f569c692923808cb6cc60a6b8f1ded7a98a528f7c8"", ""source_version"": ""UniProt reviewed entry version 230, sequence version 1; updated 2026-09-02"", ""title"": ""Alkaline phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00634.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-056_eb7ad586cd0b	UniProtKB:P00634	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00634	Binds 2 Zn(2+) ions.	"[{""reference_id"": ""UniProtKB:P00634"", ""source_assertion"": ""Reviewed annotation. UniProtKB:P00634 has the annotated cofactor Zn(2+). Binds 2 Zn(2+) ions."", ""source_locator"": ""JSON Pointer /comments/2; cofactor identity /comments/2/cofactors/0/cofactorCrossReference/id""}]"	"[{""id"": ""UniProtKB:P00634"", ""source_sha256"": ""3daf839ecfe721bb781dc3f569c692923808cb6cc60a6b8f1ded7a98a528f7c8"", ""source_version"": ""UniProt reviewed entry version 230, sequence version 1; updated 2026-09-02"", ""title"": ""Alkaline phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00634.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-057_c4b4fad4389b	UniProtKB:P07024	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07024	Binds 2 Zn(2+) ions per subunit.	"[{""reference_id"": ""UniProtKB:P07024"", ""source_assertion"": ""Reviewed annotation. UniProtKB:P07024 has the annotated cofactor Zn(2+). Binds 2 Zn(2+) ions per subunit."", ""source_locator"": ""JSON Pointer /comments/3; cofactor identity /comments/3/cofactors/0/cofactorCrossReference/id""}]"	"[{""id"": ""UniProtKB:P07024"", ""source_sha256"": ""6433b892c28ba6dbef189f4e2afdd1a86ade30b18e821d3523def97d5f2325cf"", ""source_version"": ""UniProt reviewed entry version 219, sequence version 2; updated 2026-09-02"", ""title"": ""Protein UshA"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07024.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-058_f009ba4c5dee	UniProtKB:P0AE22	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AE22	Binds 1 Mg(2+) ion per subunit.	"[{""reference_id"": ""UniProtKB:P0AE22"", ""source_assertion"": ""Reviewed annotation. UniProtKB:P0AE22 has the annotated cofactor Mg(2+). Binds 1 Mg(2+) ion per subunit."", ""source_locator"": ""JSON Pointer /comments/2; cofactor identity /comments/2/cofactors/0/cofactorCrossReference/id""}]"	"[{""id"": ""UniProtKB:P0AE22"", ""source_sha256"": ""36c63e459953942cf2363627809b4bd79c7e582965ebaf73596be84b5aa745b1"", ""source_version"": ""UniProt reviewed entry version 147, sequence version 1; updated 2026-06-10"", ""title"": ""Class B acid phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AE22.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-059_772e4f64133d	UniProtKB:P22333	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P22333	Binds 1 zinc ion per subunit.	"[{""reference_id"": ""UniProtKB:P22333"", ""source_assertion"": ""Source inference ECO:0000255. UniProtKB:P22333 has the annotated cofactor Zn(2+). Binds 1 zinc ion per subunit."", ""source_locator"": ""JSON Pointer /comments/3; cofactor identity /comments/3/cofactors/0/cofactorCrossReference/id""}]"	"[{""id"": ""UniProtKB:P22333"", ""source_sha256"": ""23e32e2f4a9fc0b04d71ef7ccef5441c01b1b100951453b1f47d623fe4782181"", ""source_version"": ""UniProt reviewed entry version 183, sequence version 2; updated 2026-09-02"", ""title"": ""Adenosine deaminase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P22333.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-060_33066810d27b	UniProtKB:P0A840	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A840	Binds 1 divalent metal cation per subunit. Highest nucleotidase activity with Mn(2+), followed by Co(2+), Ni(2+) and Mg(2+). Highest exopolyphosphatase activity with Mg(2+), followed by Co(2+) and Zn(2+). Only its nucleotidase metal series is represented; Zn support for the separate exopolyphosphatase activity is not transferred to AMP hydrolysis.	"[{""reference_id"": ""UniProtKB:P0A840"", ""source_assertion"": ""Reviewed annotation. UniProtKB:P0A840 has the annotated cofactor Mn(2+). Binds 1 divalent metal cation per subunit. Highest nucleotidase activity with Mn(2+), followed by Co(2+), Ni(2+) and Mg(2+). Highest exopolyphosphatase activity with Mg(2+), followed by Co(2+) and Zn(2+)."", ""source_locator"": ""JSON Pointer /comments/9; cofactor identity /comments/9/cofactors/0/cofactorCrossReference/id""}]"	"[{""id"": ""UniProtKB:P0A840"", ""source_sha256"": ""9ae0c1f3e2d157341dc090a0b9262e04e6d9158c6f5362d4da159e13c63d6be9"", ""source_version"": ""UniProt reviewed entry version 137, sequence version 1; updated 2026-09-02"", ""title"": ""5'/3'-nucleotidase SurE"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A840.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-061_10c8970c3507	UniProtKB:P0A840	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A840	Binds 1 divalent metal cation per subunit. Highest nucleotidase activity with Mn(2+), followed by Co(2+), Ni(2+) and Mg(2+). Highest exopolyphosphatase activity with Mg(2+), followed by Co(2+) and Zn(2+). Only its nucleotidase metal series is represented; Zn support for the separate exopolyphosphatase activity is not transferred to AMP hydrolysis.	"[{""reference_id"": ""UniProtKB:P0A840"", ""source_assertion"": ""Reviewed annotation. UniProtKB:P0A840 has the annotated cofactor Co(2+). Binds 1 divalent metal cation per subunit. Highest nucleotidase activity with Mn(2+), followed by Co(2+), Ni(2+) and Mg(2+). Highest exopolyphosphatase activity with Mg(2+), followed by Co(2+) and Zn(2+)."", ""source_locator"": ""JSON Pointer /comments/9; cofactor identity /comments/9/cofactors/1/cofactorCrossReference/id""}]"	"[{""id"": ""UniProtKB:P0A840"", ""source_sha256"": ""9ae0c1f3e2d157341dc090a0b9262e04e6d9158c6f5362d4da159e13c63d6be9"", ""source_version"": ""UniProt reviewed entry version 137, sequence version 1; updated 2026-09-02"", ""title"": ""5'/3'-nucleotidase SurE"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A840.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-062_01c008e8d677	UniProtKB:P0A840	pathwaymech:has_cofactor	CHEBI:49786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A840	Binds 1 divalent metal cation per subunit. Highest nucleotidase activity with Mn(2+), followed by Co(2+), Ni(2+) and Mg(2+). Highest exopolyphosphatase activity with Mg(2+), followed by Co(2+) and Zn(2+). Only its nucleotidase metal series is represented; Zn support for the separate exopolyphosphatase activity is not transferred to AMP hydrolysis.	"[{""reference_id"": ""UniProtKB:P0A840"", ""source_assertion"": ""Reviewed annotation. UniProtKB:P0A840 has the annotated cofactor Ni(2+). Binds 1 divalent metal cation per subunit. Highest nucleotidase activity with Mn(2+), followed by Co(2+), Ni(2+) and Mg(2+). Highest exopolyphosphatase activity with Mg(2+), followed by Co(2+) and Zn(2+)."", ""source_locator"": ""JSON Pointer /comments/9; cofactor identity /comments/9/cofactors/2/cofactorCrossReference/id""}]"	"[{""id"": ""UniProtKB:P0A840"", ""source_sha256"": ""9ae0c1f3e2d157341dc090a0b9262e04e6d9158c6f5362d4da159e13c63d6be9"", ""source_version"": ""UniProt reviewed entry version 137, sequence version 1; updated 2026-09-02"", ""title"": ""5'/3'-nucleotidase SurE"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A840.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-063_03e777190983	UniProtKB:P0A840	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A840	Binds 1 divalent metal cation per subunit. Highest nucleotidase activity with Mn(2+), followed by Co(2+), Ni(2+) and Mg(2+). Highest exopolyphosphatase activity with Mg(2+), followed by Co(2+) and Zn(2+). Only its nucleotidase metal series is represented; Zn support for the separate exopolyphosphatase activity is not transferred to AMP hydrolysis.	"[{""reference_id"": ""UniProtKB:P0A840"", ""source_assertion"": ""Reviewed annotation. UniProtKB:P0A840 has the annotated cofactor Mg(2+). Binds 1 divalent metal cation per subunit. Highest nucleotidase activity with Mn(2+), followed by Co(2+), Ni(2+) and Mg(2+). Highest exopolyphosphatase activity with Mg(2+), followed by Co(2+) and Zn(2+)."", ""source_locator"": ""JSON Pointer /comments/9; cofactor identity /comments/9/cofactors/3/cofactorCrossReference/id""}]"	"[{""id"": ""UniProtKB:P0A840"", ""source_sha256"": ""9ae0c1f3e2d157341dc090a0b9262e04e6d9158c6f5362d4da159e13c63d6be9"", ""source_version"": ""UniProt reviewed entry version 137, sequence version 1; updated 2026-09-02"", ""title"": ""5'/3'-nucleotidase SurE"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A840.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-064_8f4b279f59a4	UniProtKB:P0AF24	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF24	Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc.	"[{""reference_id"": ""UniProtKB:P0AF24"", ""source_assertion"": ""Reviewed annotation. UniProtKB:P0AF24 has the annotated cofactor Mg(2+). Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc."", ""source_locator"": ""JSON Pointer /comments/2; cofactor identity /comments/2/cofactors/0/cofactorCrossReference/id""}]"	"[{""id"": ""UniProtKB:P0AF24"", ""source_sha256"": ""2314bb79827d16c6940aba7823e56359a5e7a8596629a5473ee73f1b87a10d99"", ""source_version"": ""UniProt reviewed entry version 141, sequence version 1; updated 2026-09-02"", ""title"": ""Ribonucleotide monophosphatase NagD"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF24.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-065_b66a5c4bd1ae	UniProtKB:P0AF24	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF24	Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc.	"[{""reference_id"": ""UniProtKB:P0AF24"", ""source_assertion"": ""Reviewed annotation. UniProtKB:P0AF24 has the annotated cofactor Mn(2+). Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc."", ""source_locator"": ""JSON Pointer /comments/2; cofactor identity /comments/2/cofactors/1/cofactorCrossReference/id""}]"	"[{""id"": ""UniProtKB:P0AF24"", ""source_sha256"": ""2314bb79827d16c6940aba7823e56359a5e7a8596629a5473ee73f1b87a10d99"", ""source_version"": ""UniProt reviewed entry version 141, sequence version 1; updated 2026-09-02"", ""title"": ""Ribonucleotide monophosphatase NagD"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF24.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-066_35ba0bf67f03	UniProtKB:P0AF24	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF24	Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc.	"[{""reference_id"": ""UniProtKB:P0AF24"", ""source_assertion"": ""Reviewed annotation. UniProtKB:P0AF24 has the annotated cofactor Co(2+). Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc."", ""source_locator"": ""JSON Pointer /comments/2; cofactor identity /comments/2/cofactors/2/cofactorCrossReference/id""}]"	"[{""id"": ""UniProtKB:P0AF24"", ""source_sha256"": ""2314bb79827d16c6940aba7823e56359a5e7a8596629a5473ee73f1b87a10d99"", ""source_version"": ""UniProt reviewed entry version 141, sequence version 1; updated 2026-09-02"", ""title"": ""Ribonucleotide monophosphatase NagD"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF24.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-067_5feb8f699dfb	UniProtKB:P0AF24	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF24	Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc.	"[{""reference_id"": ""UniProtKB:P0AF24"", ""source_assertion"": ""Reviewed annotation. UniProtKB:P0AF24 has the annotated cofactor Zn(2+). Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc."", ""source_locator"": ""JSON Pointer /comments/2; cofactor identity /comments/2/cofactors/3/cofactorCrossReference/id""}]"	"[{""id"": ""UniProtKB:P0AF24"", ""source_sha256"": ""2314bb79827d16c6940aba7823e56359a5e7a8596629a5473ee73f1b87a10d99"", ""source_version"": ""UniProt reviewed entry version 141, sequence version 1; updated 2026-09-02"", ""title"": ""Ribonucleotide monophosphatase NagD"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF24.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-068_b6138415144c	UniProtKB:Q46799	pathwaymech:has_cofactor	CHEBI:71302	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19542235|UniProtKB:Q46799	Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit. This is an inferred XdhABC-subunit annotation, not measured purified occupancy. XdhA Mo-MPT and phenotype-based MCD proposals remain distinct. The 2009 MCD proposal is a competing phenotype-based interpretation, not an additional concurrent cofactor assignment.	"[{""reference_id"": ""UniProtKB:Q46799"", ""source_assertion"": ""Source inference ECO:0000250. UniProtKB:Q46799 has the annotated cofactor Mo-molybdopterin. Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit."", ""source_locator"": ""JSON Pointer /comments/3; cofactor identity /comments/3/cofactors/0/cofactorCrossReference/id""}, {""reference_id"": ""PMID:19542235"", ""source_assertion"": ""The 2009 study inferred MCD use by XdhABC/XdhD from adenine-sensitive growth phenotypes of mocA, xdhA and xdhD mutants. Purified MocA/YagTSR experiments do not directly measure the cofactor bound to XdhABC."", ""source_locator"": ""PMC2755913 full HTML #sec7, #sec18, #sec23""}]"	"[{""id"": ""PMID:19542235"", ""source_sha256"": ""facd1425ed6a47600fd0796df9597c109e050391dbad4e9c299f4ce8de40194a"", ""source_version"": ""Original retrieved 2026-10-11; access scope retained in the evidence ledger"", ""title"": ""PMID:19542235"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2755913/""}, {""id"": ""UniProtKB:Q46799"", ""source_sha256"": ""35d34f53a060da18cfb01792a8f039232b7f068a2fbd04bacb3437851c543d75"", ""source_version"": ""UniProt reviewed entry version 165, sequence version 1; updated 2026-09-02"", ""title"": ""Putative xanthine dehydrogenase molybdenum-binding subunit XdhA"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q46799.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-069_21dc40111ee3	UniProtKB:Q46800	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q46800	This is an inferred XdhABC-subunit annotation, not measured purified occupancy. XdhA Mo-MPT and phenotype-based MCD proposals remain distinct.	"[{""reference_id"": ""UniProtKB:Q46800"", ""source_assertion"": ""Source inference ECO:0000250. UniProtKB:Q46800 has the annotated cofactor FAD. "", ""source_locator"": ""JSON Pointer /comments/3; cofactor identity /comments/3/cofactors/0/cofactorCrossReference/id""}]"	"[{""id"": ""UniProtKB:Q46800"", ""source_sha256"": ""954cd16047afaff7ff02b25945af846565bf32500625ebe892c4c089587de7ce"", ""source_version"": ""UniProt reviewed entry version 160, sequence version 1; updated 2026-09-02"", ""title"": ""Putative xanthine dehydrogenase FAD-binding subunit XdhB"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q46800.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-070_bacfc404497d	UniProtKB:Q46801	pathwaymech:has_cofactor	CHEBI:190135	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q46801	Binds 2 [2Fe-2S] clusters. This is an inferred XdhABC-subunit annotation, not measured purified occupancy. XdhA Mo-MPT and phenotype-based MCD proposals remain distinct.	"[{""reference_id"": ""UniProtKB:Q46801"", ""source_assertion"": ""Source inference ECO:0000250. UniProtKB:Q46801 has the annotated cofactor [2Fe-2S] cluster. Binds 2 [2Fe-2S] clusters."", ""source_locator"": ""JSON Pointer /comments/1; cofactor identity /comments/1/cofactors/0/cofactorCrossReference/id""}]"	"[{""id"": ""UniProtKB:Q46801"", ""source_sha256"": ""84c65b9d56b3b308ce34d379e7831683e6df814acee1fea094244781317efb33"", ""source_version"": ""UniProt reviewed entry version 163, sequence version 1; updated 2026-09-02"", ""title"": ""Putative xanthine dehydrogenase iron-sulfur-binding subunit XdhC"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q46801.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-071_3385a4ad9c70	UniProtKB:P00634	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00634	Protein-location annotation; it does not locate all alternative pathway reactions in one compartment or supply a transporter.	"[{""reference_id"": ""UniProtKB:P00634"", ""source_assertion"": ""The reviewed entry annotates Periplasm. "", ""source_locator"": ""$.comments[5] (SUBCELLULAR LOCATION)""}]"	"[{""id"": ""UniProtKB:P00634"", ""source_sha256"": ""3daf839ecfe721bb781dc3f569c692923808cb6cc60a6b8f1ded7a98a528f7c8"", ""source_version"": ""UniProt reviewed entry version 230, sequence version 1; updated 2026-09-02"", ""title"": ""Alkaline phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00634.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-072_26d774fd1591	UniProtKB:P07024	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07024	Protein-location annotation; it does not locate all alternative pathway reactions in one compartment or supply a transporter.	"[{""reference_id"": ""UniProtKB:P07024"", ""source_assertion"": ""The reviewed entry annotates Periplasm. Exported from the cell, except a small proportion that is internally localized"", ""source_locator"": ""$.comments[6] (SUBCELLULAR LOCATION)""}]"	"[{""id"": ""UniProtKB:P07024"", ""source_sha256"": ""6433b892c28ba6dbef189f4e2afdd1a86ade30b18e821d3523def97d5f2325cf"", ""source_version"": ""UniProt reviewed entry version 219, sequence version 2; updated 2026-09-02"", ""title"": ""Protein UshA"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07024.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-073_2ca8efaac02a	UniProtKB:P0AE22	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AE22	Protein-location annotation; it does not locate all alternative pathway reactions in one compartment or supply a transporter.	"[{""reference_id"": ""UniProtKB:P0AE22"", ""source_assertion"": ""The reviewed entry annotates Periplasm. "", ""source_locator"": ""$.comments[6] (SUBCELLULAR LOCATION)""}]"	"[{""id"": ""UniProtKB:P0AE22"", ""source_sha256"": ""36c63e459953942cf2363627809b4bd79c7e582965ebaf73596be84b5aa745b1"", ""source_version"": ""UniProt reviewed entry version 147, sequence version 1; updated 2026-06-10"", ""title"": ""Class B acid phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AE22.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-074_f4a0255e14a9	UniProtKB:P0A840	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A840	Protein-location annotation; it does not locate all alternative pathway reactions in one compartment or supply a transporter.	"[{""reference_id"": ""UniProtKB:P0A840"", ""source_assertion"": ""The reviewed entry annotates Cytoplasm. "", ""source_locator"": ""$.comments[13] (SUBCELLULAR LOCATION)""}]"	"[{""id"": ""UniProtKB:P0A840"", ""source_sha256"": ""9ae0c1f3e2d157341dc090a0b9262e04e6d9158c6f5362d4da159e13c63d6be9"", ""source_version"": ""UniProt reviewed entry version 137, sequence version 1; updated 2026-09-02"", ""title"": ""5'/3'-nucleotidase SurE"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A840.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-075_cd46f455953a	UniProtKB:P33644	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33644	Protein-location annotation; it does not locate all alternative pathway reactions in one compartment or supply a transporter.	"[{""reference_id"": ""UniProtKB:P33644"", ""source_assertion"": ""The reviewed entry annotates Cytoplasm. Was originally thought to be periplasmic, but the presence of the N-terminal region in the structure indicates that PgeF does not possess a signal peptide and therefore is a cytoplasmic protein (PubMed:28612943, PubMed:35164571). It was subsequently confirmed that it is located in the cytoplasm (PubMed:40632566)"", ""source_locator"": ""$.comments[10] (SUBCELLULAR LOCATION)""}]"	"[{""id"": ""UniProtKB:P33644"", ""source_sha256"": ""54b8baa7128d9ff25f9a2d83c797dc95a7eca7a05ba18418feddc2b44e724d70"", ""source_version"": ""UniProt reviewed entry version 163, sequence version 1; updated 2026-06-10"", ""title"": ""Peptidoglycan editing factor PgeF"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33644.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-076_a411baf3f1ba	CHEBI:16236	pathwaymech:activates	UniProtKB:P0AE22	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AE22	Source-annotated assay effect; no unreported dose, pH or intracellular concentration is assigned. Chelator/reagent nodes preserve the named chemical identity without assuming a measured protonation state.	"[{""reference_id"": ""UniProtKB:P0AE22"", ""source_assertion"": ""Reviewed activity-regulation annotation states that ethanol activates AphA; this is enzyme-assay modulation, not transcriptional regulation."", ""source_locator"": ""$.comments[3] (ACTIVITY REGULATION)""}]"	"[{""id"": ""UniProtKB:P0AE22"", ""source_sha256"": ""36c63e459953942cf2363627809b4bd79c7e582965ebaf73596be84b5aa745b1"", ""source_version"": ""UniProt reviewed entry version 147, sequence version 1; updated 2026-06-10"", ""title"": ""Class B acid phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AE22.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-077_7d430b317f37	CHEBI:4735	pathwaymech:inhibits	UniProtKB:P0AE22	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AE22	Source-annotated assay effect; no unreported dose, pH or intracellular concentration is assigned. Chelator/reagent nodes preserve the named chemical identity without assuming a measured protonation state.	"[{""reference_id"": ""UniProtKB:P0AE22"", ""source_assertion"": ""Reviewed activity-regulation annotation states that EDTA strongly inhibits AphA; this is enzyme-assay modulation, not transcriptional regulation."", ""source_locator"": ""$.comments[3] (ACTIVITY REGULATION)""}]"	"[{""id"": ""UniProtKB:P0AE22"", ""source_sha256"": ""36c63e459953942cf2363627809b4bd79c7e582965ebaf73596be84b5aa745b1"", ""source_version"": ""UniProt reviewed entry version 147, sequence version 1; updated 2026-06-10"", ""title"": ""Class B acid phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AE22.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-078_c4b9924f9067	CHEBI:30740	pathwaymech:inhibits	UniProtKB:P0AE22	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AE22	Source-annotated assay effect; no unreported dose, pH or intracellular concentration is assigned. Chelator/reagent nodes preserve the named chemical identity without assuming a measured protonation state.	"[{""reference_id"": ""UniProtKB:P0AE22"", ""source_assertion"": ""Reviewed activity-regulation annotation states that EGTA inhibits AphA; this is enzyme-assay modulation, not transcriptional regulation."", ""source_locator"": ""$.comments[3] (ACTIVITY REGULATION)""}]"	"[{""id"": ""UniProtKB:P0AE22"", ""source_sha256"": ""36c63e459953942cf2363627809b4bd79c7e582965ebaf73596be84b5aa745b1"", ""source_version"": ""UniProt reviewed entry version 147, sequence version 1; updated 2026-06-10"", ""title"": ""Class B acid phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AE22.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-079_755aa7616509	CHEBI:44975	pathwaymech:inhibits	UniProtKB:P0AE22	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AE22	Source-annotated assay effect; no unreported dose, pH or intracellular concentration is assigned. Chelator/reagent nodes preserve the named chemical identity without assuming a measured protonation state.	"[{""reference_id"": ""UniProtKB:P0AE22"", ""source_assertion"": ""Reviewed activity-regulation annotation states that 1,10-phenanthroline inhibits AphA; this is enzyme-assay modulation, not transcriptional regulation."", ""source_locator"": ""$.comments[3] (ACTIVITY REGULATION)""}]"	"[{""id"": ""UniProtKB:P0AE22"", ""source_sha256"": ""36c63e459953942cf2363627809b4bd79c7e582965ebaf73596be84b5aa745b1"", ""source_version"": ""UniProt reviewed entry version 147, sequence version 1; updated 2026-06-10"", ""title"": ""Class B acid phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AE22.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-080_4f00dd7287aa	CHEBI:46837	pathwaymech:inhibits	UniProtKB:P0AE22	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AE22	Source-annotated assay effect; no unreported dose, pH or intracellular concentration is assigned. Chelator/reagent nodes preserve the named chemical identity without assuming a measured protonation state.	"[{""reference_id"": ""UniProtKB:P0AE22"", ""source_assertion"": ""Reviewed activity-regulation annotation states that dipicolinic acid inhibits AphA; this is enzyme-assay modulation, not transcriptional regulation."", ""source_locator"": ""$.comments[3] (ACTIVITY REGULATION)""}]"	"[{""id"": ""UniProtKB:P0AE22"", ""source_sha256"": ""36c63e459953942cf2363627809b4bd79c7e582965ebaf73596be84b5aa745b1"", ""source_version"": ""UniProt reviewed entry version 147, sequence version 1; updated 2026-06-10"", ""title"": ""Class B acid phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AE22.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-081_8cbc7ee623d8	CHEBI:33838	pathwaymech:inhibits	UniProtKB:P0AE22	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AE22	Source-annotated assay effect; no unreported dose, pH or intracellular concentration is assigned. Chelator/reagent nodes preserve the named chemical identity without assuming a measured protonation state.	"[{""reference_id"": ""UniProtKB:P0AE22"", ""source_assertion"": ""Reviewed activity-regulation annotation states that nucleosides inhibit AphA; this is enzyme-assay modulation, not transcriptional regulation."", ""source_locator"": ""$.comments[3] (ACTIVITY REGULATION)""}]"	"[{""id"": ""UniProtKB:P0AE22"", ""source_sha256"": ""36c63e459953942cf2363627809b4bd79c7e582965ebaf73596be84b5aa745b1"", ""source_version"": ""UniProt reviewed entry version 147, sequence version 1; updated 2026-06-10"", ""title"": ""Class B acid phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AE22.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-082_962e87831a50	CHEBI:43474	pathwaymech:inhibits	UniProtKB:P0AE22	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AE22	Source-annotated assay effect; no unreported dose, pH or intracellular concentration is assigned. Chelator/reagent nodes preserve the named chemical identity without assuming a measured protonation state.	"[{""reference_id"": ""UniProtKB:P0AE22"", ""source_assertion"": ""Reviewed activity-regulation annotation states that inorganic phosphate inhibits AphA; this is enzyme-assay modulation, not transcriptional regulation."", ""source_locator"": ""$.comments[3] (ACTIVITY REGULATION)""}]"	"[{""id"": ""UniProtKB:P0AE22"", ""source_sha256"": ""36c63e459953942cf2363627809b4bd79c7e582965ebaf73596be84b5aa745b1"", ""source_version"": ""UniProt reviewed entry version 147, sequence version 1; updated 2026-06-10"", ""title"": ""Class B acid phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AE22.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-083_d97416c2d821	CHEBI:29108	pathwaymech:inhibits	UniProtKB:P0AE22	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AE22	Source-annotated assay effect; no unreported dose, pH or intracellular concentration is assigned. Chelator/reagent nodes preserve the named chemical identity without assuming a measured protonation state.	"[{""reference_id"": ""UniProtKB:P0AE22"", ""source_assertion"": ""Reviewed activity-regulation annotation states that calcium(2+) inhibits AphA; this is enzyme-assay modulation, not transcriptional regulation."", ""source_locator"": ""$.comments[3] (ACTIVITY REGULATION)""}]"	"[{""id"": ""UniProtKB:P0AE22"", ""source_sha256"": ""36c63e459953942cf2363627809b4bd79c7e582965ebaf73596be84b5aa745b1"", ""source_version"": ""UniProt reviewed entry version 147, sequence version 1; updated 2026-06-10"", ""title"": ""Class B acid phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AE22.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-084_42364453ca42	CHEBI:16213	pathwaymech:inhibits	UniProtKB:P22333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P22333	Inhibitor annotation from the reviewed protein; its cited full primary methods were not inspected.	"[{""reference_id"": ""UniProtKB:P22333"", ""source_assertion"": ""Reviewed Add activity is inhibited by coformycin (ECO:0000269, cited PMID357905). The original retrieved paper metadata has no abstract, so detailed assay conditions are not claimed."", ""source_locator"": ""$.comments[4] (ACTIVITY REGULATION)""}]"	"[{""id"": ""UniProtKB:P22333"", ""source_sha256"": ""23e32e2f4a9fc0b04d71ef7ccef5441c01b1b100951453b1f47d623fe4782181"", ""source_version"": ""UniProt reviewed entry version 183, sequence version 2; updated 2026-09-02"", ""title"": ""Adenosine deaminase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P22333.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-085_46fe8f4cf1a5	CHEBI:28420	pathwaymech:inhibits	UniProtKB:P22333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P22333	Inhibitor annotation from the reviewed protein; its cited full primary methods were not inspected.	"[{""reference_id"": ""UniProtKB:P22333"", ""source_assertion"": ""Reviewed Add activity is inhibited by p-chloromercuribenzoate (ECO:0000269, cited PMID357905). The original retrieved paper metadata has no abstract, so detailed assay conditions are not claimed."", ""source_locator"": ""$.comments[4] (ACTIVITY REGULATION)""}]"	"[{""id"": ""UniProtKB:P22333"", ""source_sha256"": ""23e32e2f4a9fc0b04d71ef7ccef5441c01b1b100951453b1f47d623fe4782181"", ""source_version"": ""UniProt reviewed entry version 183, sequence version 2; updated 2026-09-02"", ""title"": ""Adenosine deaminase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P22333.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-086_9b4f495360db	CHEBI:33206	pathwaymech:inhibits	UniProtKB:P45563	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P45563	Assay inhibition; the annotation abbreviates the sulfonic reagent p-CMB, which is not used to merge it with the benzoic reagent.	"[{""reference_id"": ""UniProtKB:P45563"", ""source_assertion"": ""Reviewed XapA is rapidly inactivated by p-chloromercuriphenylsulfonic acid; this is the sulfonic reagent, distinct from Add's chloromercuribenzoate."", ""source_locator"": ""$.comments[2] (ACTIVITY REGULATION)""}]"	"[{""id"": ""UniProtKB:P45563"", ""source_sha256"": ""eec50a639f7798e4b2aff2b3319ffd797a9e47806646ef8c15ab0339156f6fd1"", ""source_version"": ""UniProt reviewed entry version 176, sequence version 2; updated 2026-09-02"", ""title"": ""Purine nucleoside phosphorylase 2"", ""url"": ""https://rest.uniprot.org/uniprotkb/P45563.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-087_6c8e8bb0cb29	CHEBI:18320	pathwaymech:activates	UniProtKB:P45563	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P45563	Activity restoration only after the source-specified chemical inactivation.	"[{""reference_id"": ""UniProtKB:P45563"", ""source_assertion"": ""Dithiothreitol incubation restores XapA activity after inactivation by the chloromercuriphenylsulfonic reagent. This is conditional recovery, not general activation of untreated enzyme."", ""source_locator"": ""$.comments[2] (ACTIVITY REGULATION)""}]"	"[{""id"": ""UniProtKB:P45563"", ""source_sha256"": ""eec50a639f7798e4b2aff2b3319ffd797a9e47806646ef8c15ab0339156f6fd1"", ""source_version"": ""UniProt reviewed entry version 176, sequence version 2; updated 2026-09-02"", ""title"": ""Purine nucleoside phosphorylase 2"", ""url"": ""https://rest.uniprot.org/uniprotkb/P45563.json""}]"	"[{""description"": ""XapA after inactivation by p-chloromercuriphenylsulfonic acid; subsequent dithiothreitol incubation restores activity."", ""endpoint"": ""object"", ""evidence"": [{""reference_id"": ""UniProtKB:P45563"", ""source_assertion"": ""Dithiothreitol incubation restores XapA activity after inactivation by the chloromercuriphenylsulfonic reagent. This is conditional recovery, not general activation of untreated enzyme."", ""source_locator"": ""$.comments[2] (ACTIVITY REGULATION)""}], ""kind"": ""molecular_state""}]"
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-088_2c3d62f331aa	CHEBI:17326	pathwaymech:inhibits	UniProtKB:P0A840	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A840	Source-scoped class-level inhibition; no invented exact nucleotide dose or universal effect across every triphosphate.	"[{""reference_id"": ""UniProtKB:P0A840"", ""source_assertion"": ""SurE is inhibited by various tested ribo- or deoxyribonucleoside 5-prime-triphosphates but is insensitive to nucleoside diphosphates. The class node does not mean every member was tested."", ""source_locator"": ""$.comments[10] (ACTIVITY REGULATION)""}]"	"[{""id"": ""UniProtKB:P0A840"", ""source_sha256"": ""9ae0c1f3e2d157341dc090a0b9262e04e6d9158c6f5362d4da159e13c63d6be9"", ""source_version"": ""UniProt reviewed entry version 137, sequence version 1; updated 2026-09-02"", ""title"": ""5'/3'-nucleotidase SurE"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A840.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-089_8453c1d9dc38	CHEBI:29036	pathwaymech:inhibits	EcoCyc:DEOD-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:DEOD-CPLX	Reviewed native assay annotation. Phosphate negative cooperativity is retained separately as substrate-binding behavior, not equated with inhibition.	"[{""reference_id"": ""EcoCyc:DEOD-CPLX"", ""source_assertion"": ""The native DeoD comment reports inhibition by Cu(2+). It also records conflicting reports for nickel and sulfate; those disputed effects are not asserted here."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""DEOD-CPLX\""]/comment""}]"	"[{""id"": ""EcoCyc:DEOD-CPLX"", ""source_sha256"": ""87ab3e0bda1204524ecaac08b36b83b254c9b976c829585797b72ea82d508b15"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""purine nucleoside phosphorylase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:DEOD-CPLX""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-090_b42f44f02369	CHEBI:29105	pathwaymech:inhibits	EcoCyc:DEOD-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:DEOD-CPLX	Reviewed native assay annotation. Phosphate negative cooperativity is retained separately as substrate-binding behavior, not equated with inhibition.	"[{""reference_id"": ""EcoCyc:DEOD-CPLX"", ""source_assertion"": ""The native DeoD comment reports inhibition by Zn(2+). It also records conflicting reports for nickel and sulfate; those disputed effects are not asserted here."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""DEOD-CPLX\""]/comment""}]"	"[{""id"": ""EcoCyc:DEOD-CPLX"", ""source_sha256"": ""87ab3e0bda1204524ecaac08b36b83b254c9b976c829585797b72ea82d508b15"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""purine nucleoside phosphorylase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:DEOD-CPLX""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-091_6408103ddc89	UniProtKB:P33644	pathwaymech:catalyzes	RHEA:24409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:31978345|UniProtKB:P33644	Recombinant in-vitro alternative. No native cellular flux, Cu/Zn requirement or catalytic-triad mechanism is inferred.	"[{""reference_id"": ""PMID:31978345"", ""source_assertion"": ""The 2020 study reports adenosine deamination by recombinant affinity-purified YfiH/PgeF in vitro. The result does not demonstrate its contribution to physiological purine flux in E. coli."", ""source_locator"": ""PMC6978800 full HTML #sec2.3 Fig3 and #sec4.4.10""}, {""reference_id"": ""UniProtKB:P33644"", ""source_assertion"": ""Reviewed P33644 records RHEA:24408 adenosine deamination, with experimental evidence citing PMID31978345."", ""source_locator"": ""$.comments[5]""}]"	"[{""id"": ""PMID:31978345"", ""source_sha256"": ""004bf5f4e63ff93b91040d2ad343e2d4efea38ec6e6a2da3abba5173b3294ae2"", ""source_version"": ""Original retrieved 2026-10-11; access scope retained in the evidence ledger"", ""title"": ""PMID:31978345"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC6978800/""}, {""id"": ""UniProtKB:P33644"", ""source_sha256"": ""54b8baa7128d9ff25f9a2d83c797dc95a7eca7a05ba18418feddc2b44e724d70"", ""source_version"": ""UniProt reviewed entry version 163, sequence version 1; updated 2026-06-10"", ""title"": ""Peptidoglycan editing factor PgeF"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33644.json""}]"	"[{""description"": ""Recombinant K-12 P33644/YfiH sequence in pPSG-IBA105, expressed in BL21(DE3), StrepTrap- and size-exclusion-purified; exact tag terminus and cleavage status are unspecified in the inspected methods."", ""endpoint"": ""subject"", ""evidence"": [{""reference_id"": ""PMID:31978345"", ""source_assertion"": ""The 2020 YfiH construct used synthesized K-12 UniProt P33644 sequence in pPSG-IBA105, expressed in BL21(DE3), purified by StrepTrap and size exclusion. Exact YfiH tag terminus and cleavage status are not specified in the inspected methods."", ""source_locator"": ""PMC6978800 full HTML #sec4.4.1 and #sec4.4.4""}], ""kind"": ""experimental_construct""}]"
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-092_c1cec32054c0	UniProtKB:P33644	pathwaymech:catalyzes	RHEA:27647	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:31978345|UniProtKB:P33644	Recombinant in-vitro alternative. No native cellular flux, Cu/Zn requirement or catalytic-triad mechanism is inferred.	"[{""reference_id"": ""PMID:31978345"", ""source_assertion"": ""The 2020 study reports inosine phosphorolysis by recombinant affinity-purified YfiH/PgeF in vitro. The result does not demonstrate its contribution to physiological purine flux in E. coli."", ""source_locator"": ""PMC6978800 full HTML #sec2.3 Fig3 and #sec4.4.10""}, {""reference_id"": ""UniProtKB:P33644"", ""source_assertion"": ""Reviewed P33644 records RHEA:27646 inosine phosphorolysis, with experimental evidence citing PMID31978345."", ""source_locator"": ""$.comments[3]""}]"	"[{""id"": ""PMID:31978345"", ""source_sha256"": ""004bf5f4e63ff93b91040d2ad343e2d4efea38ec6e6a2da3abba5173b3294ae2"", ""source_version"": ""Original retrieved 2026-10-11; access scope retained in the evidence ledger"", ""title"": ""PMID:31978345"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC6978800/""}, {""id"": ""UniProtKB:P33644"", ""source_sha256"": ""54b8baa7128d9ff25f9a2d83c797dc95a7eca7a05ba18418feddc2b44e724d70"", ""source_version"": ""UniProt reviewed entry version 163, sequence version 1; updated 2026-06-10"", ""title"": ""Peptidoglycan editing factor PgeF"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33644.json""}]"	"[{""description"": ""Recombinant K-12 P33644/YfiH sequence in pPSG-IBA105, expressed in BL21(DE3), StrepTrap- and size-exclusion-purified; exact tag terminus and cleavage status are unspecified in the inspected methods."", ""endpoint"": ""subject"", ""evidence"": [{""reference_id"": ""PMID:31978345"", ""source_assertion"": ""The 2020 YfiH construct used synthesized K-12 UniProt P33644 sequence in pPSG-IBA105, expressed in BL21(DE3), purified by StrepTrap and size exclusion. Exact YfiH tag terminus and cleavage status are not specified in the inspected methods."", ""source_locator"": ""PMC6978800 full HTML #sec4.4.1 and #sec4.4.4""}], ""kind"": ""experimental_construct""}]"
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-093_911e2a15ca33	UniProtKB:P33644	pathwaymech:catalyzes	RHEA:27647	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:40632566	Weak in-vitro PNP: 2.5 micromolar protein, 1 microgram substrate/100 microlitres PBS, 16 h at 37 C; no detected activity at 5 nM and no deoD-mutant growth rescue on inosine. Ni-NTA purification does not make nickel a cofactor.	"[{""reference_id"": ""PMID:40632566"", ""source_assertion"": ""Recombinant PgeF/YfiH phosphorolyzes inosine in vitro. The 2025 study detected weak activity at 2.5 μM protein, none at 5 nM, and no rescue of a deoD mutant on inosine as sole carbon source."", ""source_locator"": ""PMC12280929 full HTML #s6, #s11, #s20""}]"	"[{""id"": ""PMID:40632566"", ""source_sha256"": ""1c72c45c7ff90b488cb9b4d2af3865d92e015530ff7e28bbbc308856ff96559d"", ""source_version"": ""Original retrieved 2026-10-11; access scope retained in the evidence ledger"", ""title"": ""PMID:40632566"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC12280929/""}]"	"[{""description"": ""Recombinant PgeF expressed in BL21(lambdaDE3) lacking PgeF and purified by Ni2+-NTA; exact tag end/removal is not assigned because supplemental construct tables were not inspected."", ""endpoint"": ""subject"", ""evidence"": [{""reference_id"": ""PMID:40632566"", ""source_assertion"": ""The 2025 PgeF proteins were expressed in BL21(λDE3) lacking PgeF and purified by Ni2+-NTA. Supplemental construct details were not inspected; do not invent a tag end, tag removal, or exact wild-type assembly for these assays."", ""source_locator"": ""PMC12280929 full HTML #s13, #s18, #s20""}], ""kind"": ""experimental_construct""}]"
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-094_5c99da3807d7	UniProtKB:P23841	BFO:0000050	EcoCyc:CPLX0-7681	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-7681|EcoCyc:EG11146-MONOMER	Native ligand-bound regulatory state; no exact subunit or ligand occupancy is assigned.	"[{""reference_id"": ""EcoCyc:CPLX0-7681"", ""source_assertion"": ""EcoCyc CPLX0-7681 is the XapR–xanthosine transcriptional activator, with direct components EG11146-MONOMER and XANTHOSINE. Neither component has a stoichiometric coefficient in the native record."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""CPLX0-7681\""]/component""}, {""reference_id"": ""EcoCyc:EG11146-MONOMER"", ""source_assertion"": ""The native XapR monomer has a direct UNIPROT P23841 dblink. The native state separately contains XANTHOSINE."", ""source_locator"": ""ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}]"	"[{""id"": ""EcoCyc:CPLX0-7681"", ""source_sha256"": ""e779e3dcc9e2fd43259a7f3b6846bfde56b5a3b5e16267bfabd72436316e27a3"", ""source_version"": ""Original retrieved 2026-10-11; access scope retained in the evidence ledger"", ""title"": ""EcoCyc:CPLX0-7681"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:CPLX0-7681""}, {""id"": ""EcoCyc:EG11146-MONOMER"", ""source_sha256"": ""f8bb84122ca8cf64e42ae076906505627e5251b89e1044f879081d5ae9f6154e"", ""source_version"": ""Original retrieved 2026-10-11; access scope retained in the evidence ledger"", ""title"": ""EcoCyc:EG11146-MONOMER"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:EG11146-MONOMER""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-095_173759e77aeb	CHEBI:18107	BFO:0000050	EcoCyc:CPLX0-7681	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-7681|EcoCyc:XANTHOSINE	Native ligand-bound regulatory state; no exact subunit or ligand occupancy is assigned.	"[{""reference_id"": ""EcoCyc:CPLX0-7681"", ""source_assertion"": ""EcoCyc CPLX0-7681 is the XapR–xanthosine transcriptional activator, with direct components EG11146-MONOMER and XANTHOSINE. Neither component has a stoichiometric coefficient in the native record."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""CPLX0-7681\""]/component""}, {""reference_id"": ""EcoCyc:XANTHOSINE"", ""source_assertion"": ""The issuing ECOLI XANTHOSINE compound has a direct ChEBI 18107 unification cross-reference."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""XANTHOSINE\""]/dblink[dblink-db=\""CHEBI\""]/dblink-oid""}]"	"[{""id"": ""EcoCyc:CPLX0-7681"", ""source_sha256"": ""e779e3dcc9e2fd43259a7f3b6846bfde56b5a3b5e16267bfabd72436316e27a3"", ""source_version"": ""Original retrieved 2026-10-11; access scope retained in the evidence ledger"", ""title"": ""EcoCyc:CPLX0-7681"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:CPLX0-7681""}, {""id"": ""EcoCyc:XANTHOSINE"", ""source_sha256"": ""1a43cc12235f5f37aa41ef67e65dc8e80d33e34e34ecfc55b40e113be49b25fe"", ""source_version"": ""ECOLI 27.0; retrieved 2026-10-11"", ""title"": ""XANTHOSINE native chemical identity"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:XANTHOSINE""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-096_a4388fbde859	EcoCyc:CPLX0-7681	pathwaymech:activates	Entrez:946878	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-7681|EcoCyc:TU0-45226|EcoCyc:TU301|Entrez:946878	Positive transcriptional regulation projected through native promoter/TU/gene membership. Free XapR is not substituted for its xanthosine-bound state.	"[{""reference_id"": ""EcoCyc:CPLX0-7681"", ""source_assertion"": ""Native positive regulation targets xapAp and xapAp2. This gene-level edge projects their transcription-unit membership to xapA, not catalytic activation of XapA enzyme."", ""source_locator"": ""ptools-xml/Protein/regulates/Regulation[@frameid=\""REG0-5106\""]; Regulation[@frameid=\""REG0-15010\""]""}, {""reference_id"": ""EcoCyc:TU301"", ""source_assertion"": ""The native xapAB transcription unit contains promoter PM501 and gene G85 (xapA)."", ""source_locator"": ""ptools-xml/Transcription-Unit/component""}, {""reference_id"": ""EcoCyc:TU0-45226"", ""source_assertion"": ""The second native transcription unit contains promoter PM0-46524 and gene G85 (xapA)."", ""source_locator"": ""ptools-xml/Transcription-Unit/component""}, {""reference_id"": ""Entrez:946878"", ""source_assertion"": ""The issuing Gene record resolves MG1655 xapA, locus b2407, with UniProt P45563 and EcoCyc G85 cross-references."", ""source_locator"": ""Entrezgene-Set/Entrezgene/Entrezgene_gene/Gene-ref; Entrezgene_source; Entrezgene_unique-keys; Entrezgene-Set/Entrezgene/Entrezgene_locus/Gene-commentary/Gene-commentary_products/Gene-commentary/Gene-commentary_source/Other-source/Other-source_src/Dbtag[Dbtag_db=\""UniProtKB/Swiss-Prot\""]/Dbtag_tag/Object-id/Object-id_str""}]"	"[{""id"": ""EcoCyc:CPLX0-7681"", ""source_sha256"": ""e779e3dcc9e2fd43259a7f3b6846bfde56b5a3b5e16267bfabd72436316e27a3"", ""source_version"": ""Original retrieved 2026-10-11; access scope retained in the evidence ledger"", ""title"": ""EcoCyc:CPLX0-7681"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:CPLX0-7681""}, {""id"": ""EcoCyc:TU0-45226"", ""source_sha256"": ""134d468b8ebabaea60ba4331586eb95e723b12675acc86a70c71766234d645fe"", ""source_version"": ""Original retrieved 2026-10-11; access scope retained in the evidence ledger"", ""title"": ""EcoCyc:TU0-45226"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:TU0-45226""}, {""id"": ""EcoCyc:TU301"", ""source_sha256"": ""9374914f5eb0f8151f9c35f384df180f383db06e7158b2f8a21fc0905d7089a1"", ""source_version"": ""Original retrieved 2026-10-11; access scope retained in the evidence ledger"", ""title"": ""EcoCyc:TU301"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:TU301""}, {""id"": ""Entrez:946878"", ""source_sha256"": ""8ff2ed2f6840d116cc022e79ad8d84caf22bb557630281f5154744669bdb7c05"", ""source_version"": ""Original retrieved 2026-10-11; access scope retained in the evidence ledger"", ""title"": ""Entrez:946878"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=gene&id=946878&retmode=xml""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-097_792fb8066a96	CHEBI:28997	pathwaymech:activates	Entrez:946878	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P45563	Expression-level induction by deoxyinosine, weaker than xanthosine; no direct binding to XapR or catalytic allostery is inferred.	"[{""reference_id"": ""UniProtKB:P45563"", ""source_assertion"": ""Reviewed XapA expression is induced by xanthosine and to a lesser extent deoxyinosine; full expression requires the XapR-xanthosine activator."", ""source_locator"": ""$.comments[7] (INDUCTION)""}]"	"[{""id"": ""UniProtKB:P45563"", ""source_sha256"": ""eec50a639f7798e4b2aff2b3319ffd797a9e47806646ef8c15ab0339156f6fd1"", ""source_version"": ""UniProt reviewed entry version 176, sequence version 2; updated 2026-09-02"", ""title"": ""Purine nucleoside phosphorylase 2"", ""url"": ""https://rest.uniprot.org/uniprotkb/P45563.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-098_92d256736856	CHEBI:59640	pathwaymech:activates	Entrez:945283	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Entrez:945283|UniProtKB:P0AF24	Inferred expression induction, not direct activation or ligand binding to UmpH. The chemical node retains the source's nonspecific N-acetylglucosamine label.	"[{""reference_id"": ""UniProtKB:P0AF24"", ""source_assertion"": ""Reviewed UmpH/NagD is annotated as induced by N-acetylglucosamine (ECO:0000305). This is an inferred expression-induction annotation, not direct catalytic activation."", ""source_locator"": ""$.comments[5] (INDUCTION; ECO:0000305)""}, {""reference_id"": ""Entrez:945283"", ""source_assertion"": ""The issuing Gene record identifies MG1655 umpH (b0675), with P0AF24 and EcoCyc EG10634 cross-references."", ""source_locator"": ""Entrezgene-Set/Entrezgene/Entrezgene_gene/Gene-ref; Entrezgene_source; Entrezgene_unique-keys; Entrezgene-Set/Entrezgene/Entrezgene_locus/Gene-commentary/Gene-commentary_products/Gene-commentary/Gene-commentary_source/Other-source/Other-source_src/Dbtag[Dbtag_db=\""UniProtKB/Swiss-Prot\""]/Dbtag_tag/Object-id/Object-id_str""}]"	"[{""id"": ""Entrez:945283"", ""source_sha256"": ""b8c40295b204f7359dd5d3d7940050a57e69b14d6a481df560b77afea57ba3d5"", ""source_version"": ""Original retrieved 2026-10-11; access scope retained in the evidence ledger"", ""title"": ""Entrez:945283"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=gene&id=945283&retmode=xml""}, {""id"": ""UniProtKB:P0AF24"", ""source_sha256"": ""2314bb79827d16c6940aba7823e56359a5e7a8596629a5473ee73f1b87a10d99"", ""source_version"": ""UniProt reviewed entry version 141, sequence version 1; updated 2026-09-02"", ""title"": ""Ribonucleotide monophosphatase NagD"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF24.json""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-099_a4f77a6d47ae	CHEBI:17596	pathwaymech:activates	Entrez:945654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:DEOD-CPLX|Entrez:945654	Native source-level induction; historical full methods were not inspected. The generic deoxyribonucleoside class does not assert that every member was tested.	"[{""reference_id"": ""EcoCyc:DEOD-CPLX"", ""source_assertion"": ""The native comment reports induction of DeoD expression by growth with inosine. This is expression regulation, not a direct allosteric activity effect."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""DEOD-CPLX\""]/comment""}, {""reference_id"": ""Entrez:945654"", ""source_assertion"": ""The issuing Gene record identifies MG1655 deoD (b4384), with P0ABP8 and EcoCyc EG10222 cross-references."", ""source_locator"": ""Entrezgene-Set/Entrezgene/Entrezgene_gene/Gene-ref; Entrezgene_source; Entrezgene_unique-keys; Entrezgene-Set/Entrezgene/Entrezgene_locus/Gene-commentary/Gene-commentary_products/Gene-commentary/Gene-commentary_source/Other-source/Other-source_src/Dbtag[Dbtag_db=\""UniProtKB/Swiss-Prot\""]/Dbtag_tag/Object-id/Object-id_str""}]"	"[{""id"": ""EcoCyc:DEOD-CPLX"", ""source_sha256"": ""87ab3e0bda1204524ecaac08b36b83b254c9b976c829585797b72ea82d508b15"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""purine nucleoside phosphorylase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:DEOD-CPLX""}, {""id"": ""Entrez:945654"", ""source_sha256"": ""4d936a378d5a7519c2f78109858fb19c264264a893d83cc413c6cc2e87917fe8"", ""source_version"": ""Original retrieved 2026-10-11; access scope retained in the evidence ledger"", ""title"": ""Entrez:945654"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=gene&id=945654&retmode=xml""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-100_1a07bef87989	CHEBI:16750	pathwaymech:activates	Entrez:945654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:DEOD-CPLX|Entrez:945654	Native source-level induction; historical full methods were not inspected. The generic deoxyribonucleoside class does not assert that every member was tested.	"[{""reference_id"": ""EcoCyc:DEOD-CPLX"", ""source_assertion"": ""The native comment reports induction of DeoD expression by growth with guanosine. This is expression regulation, not a direct allosteric activity effect."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""DEOD-CPLX\""]/comment""}, {""reference_id"": ""Entrez:945654"", ""source_assertion"": ""The issuing Gene record identifies MG1655 deoD (b4384), with P0ABP8 and EcoCyc EG10222 cross-references."", ""source_locator"": ""Entrezgene-Set/Entrezgene/Entrezgene_gene/Gene-ref; Entrezgene_source; Entrezgene_unique-keys; Entrezgene-Set/Entrezgene/Entrezgene_locus/Gene-commentary/Gene-commentary_products/Gene-commentary/Gene-commentary_source/Other-source/Other-source_src/Dbtag[Dbtag_db=\""UniProtKB/Swiss-Prot\""]/Dbtag_tag/Object-id/Object-id_str""}]"	"[{""id"": ""EcoCyc:DEOD-CPLX"", ""source_sha256"": ""87ab3e0bda1204524ecaac08b36b83b254c9b976c829585797b72ea82d508b15"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""purine nucleoside phosphorylase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:DEOD-CPLX""}, {""id"": ""Entrez:945654"", ""source_sha256"": ""4d936a378d5a7519c2f78109858fb19c264264a893d83cc413c6cc2e87917fe8"", ""source_version"": ""Original retrieved 2026-10-11; access scope retained in the evidence ledger"", ""title"": ""Entrez:945654"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=gene&id=945654&retmode=xml""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-101_cdd6d9c9497f	CHEBI:18274	pathwaymech:activates	Entrez:945654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:DEOD-CPLX|Entrez:945654	Native source-level induction; historical full methods were not inspected. The generic deoxyribonucleoside class does not assert that every member was tested.	"[{""reference_id"": ""EcoCyc:DEOD-CPLX"", ""source_assertion"": ""The native comment reports induction of DeoD expression by growth with purine and pyrimidine deoxyribonucleosides. This is expression regulation, not a direct allosteric activity effect."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""DEOD-CPLX\""]/comment""}, {""reference_id"": ""Entrez:945654"", ""source_assertion"": ""The issuing Gene record identifies MG1655 deoD (b4384), with P0ABP8 and EcoCyc EG10222 cross-references."", ""source_locator"": ""Entrezgene-Set/Entrezgene/Entrezgene_gene/Gene-ref; Entrezgene_source; Entrezgene_unique-keys; Entrezgene-Set/Entrezgene/Entrezgene_locus/Gene-commentary/Gene-commentary_products/Gene-commentary/Gene-commentary_source/Other-source/Other-source_src/Dbtag[Dbtag_db=\""UniProtKB/Swiss-Prot\""]/Dbtag_tag/Object-id/Object-id_str""}]"	"[{""id"": ""EcoCyc:DEOD-CPLX"", ""source_sha256"": ""87ab3e0bda1204524ecaac08b36b83b254c9b976c829585797b72ea82d508b15"", ""source_version"": ""Pathway Tools ECOLI PGDB 27.0; original retrieved 2026-10-11"", ""title"": ""purine nucleoside phosphorylase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:DEOD-CPLX""}, {""id"": ""Entrez:945654"", ""source_sha256"": ""4d936a378d5a7519c2f78109858fb19c264264a893d83cc413c6cc2e87917fe8"", ""source_version"": ""Original retrieved 2026-10-11; access scope retained in the evidence ledger"", ""title"": ""Entrez:945654"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=gene&id=945654&retmode=xml""}]"	""
pathwaymech:MetaCyc_SALVADEHYPOX-PWY_adenosine-degradation-102_c21ed4fbc6ee	CHEBI:16708	pathwaymech:activates	Entrez:945851	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Entrez:945851|PMID:21572102	Measured transcript-level induction in wild-type E. coli K-12 MG1655: 17.61-fold after adenine supplementation (100 micrograms/mL) in M9 with 2 g/L glucose, at 37 C with agitation and sampled at mid-log phase. This is gene-expression context, not direct activation of Add protein or evidence of direct PurR regulation.	"[{""reference_id"": ""PMID:21572102"", ""source_assertion"": ""In wild-type E. coli K-12 MG1655 grown to mid-log phase at 37 C in M9 with 2 g/L glucose, 100 micrograms/mL adenine increased add transcript 17.61-fold. The study explicitly excludes add from direct PurR regulation."", ""source_locator"": ""PMC3159470 full HTML #sec3 (strain and culture); #sec9 (wild-type transcript response); #sec13 (direct PurR boundary)""}, {""reference_id"": ""Entrez:945851"", ""source_assertion"": ""The issuing Gene original identifies MG1655 add, locus b1623, taxon511145, and directly links its protein product to UniProtKB P22333."", ""source_locator"": ""Entrezgene-Set/Entrezgene/Entrezgene_gene/Gene-ref; Entrezgene-Set/Entrezgene/Entrezgene_source/BioSource/BioSource_org/Org-ref/Org-ref_db/Dbtag[Dbtag_db=\""taxon\""]/Dbtag_tag/Object-id/Object-id_id; Entrezgene-Set/Entrezgene/Entrezgene_locus/Gene-commentary/Gene-commentary_products/Gene-commentary/Gene-commentary_source/Other-source/Other-source_src/Dbtag[Dbtag_db=\""UniProtKB/Swiss-Prot\""]/Dbtag_tag/Object-id/Object-id_str""}]"	"[{""id"": ""Entrez:945851"", ""source_sha256"": ""9743f5cf40e9bada0c584472b0b7000174a5918e39c184d37bd03be2693e0757"", ""source_version"": ""NCBI Gene original fetched 2026-10-11; update 2026-09-03"", ""title"": ""NCBI Gene add (b1623), E. coli MG1655"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=gene&id=945851&rettype=xml""}, {""id"": ""PMID:21572102"", ""source_sha256"": ""6894d332e33b1779d56624171bb0c65fa765c512f806b4e1580d97b51378a1aa"", ""source_version"": ""Primary article full HTML retained 2026-10-11; Methods and Results re-inspected 2026-10-11"", ""title"": ""The PurR regulon in Escherichia coli K-12 MG1655"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3159470/""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-001_d3ca13a788fe	gomodel:ADENYL-KIN-RXN	BFO:0000050	GO:0046086	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:ADENYL-KIN-RXN BFO:0000050 gomodel:YeastPathways_PWY-7219/YeastPathways_PWY-7219."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/0; endpoint types: /individuals/0/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-002_003156d077d0	gomodel:ADENYL-KIN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:ADENYL-KIN-RXN BFO:0000066 gomodel:reaction_ADENYL-KIN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/1; endpoint types: /individuals/0/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-003_3f075d95ebfa	gomodel:AMPSYN-RXN	RO:0002234	CHEBI:29806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:AMPSYN-RXN RO:0002234 gomodel:CHEBI_29806_AMPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/2; endpoint types: /individuals/2/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-004_4f146c4b818c	SGD:S000005164	pathwaymech:enables	gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN RO:0002333 gomodel:YNL220W-MONOMER_ADENYLOSUCCINATE-SYNTHASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/3; endpoint types: /individuals/1/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-006_b4cad560a2e0	gomodel:ADENYL-KIN-RXN	RO:0002233	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:ADENYL-KIN-RXN RO:0002233 gomodel:CHEBI_456215_AMPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/5; endpoint types: /individuals/0/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-007_454adb3f1fe5	gomodel:ADENYL-KIN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:ADENYL-KIN-RXN RO:0002233 gomodel:CHEBI_30616_ADENYL-KIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/6; endpoint types: /individuals/0/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-008_b56ac0d32fa0	gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN	BFO:0000050	GO:0046086	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN BFO:0000050 gomodel:YeastPathways_PWY-7219/YeastPathways_PWY-7219."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/7; endpoint types: /individuals/1/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-010_b3eb2437d6c2	SGD:S000000972	pathwaymech:enables	gomodel:YeastPathways_PWY-7219/6a4c244800000590	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7219/6a4c244800000590 RO:0002333 gomodel:YeastPathways_PWY-7219/6a4c244800000593."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/9; endpoint types: /individuals/40/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-011_abc308aec8f5	gomodel:AMPSYN-RXN	BFO:0000050	GO:0046086	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:AMPSYN-RXN BFO:0000050 gomodel:YeastPathways_PWY-7219/YeastPathways_PWY-7219."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/10; endpoint types: /individuals/2/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-012_c791c646bbbb	SGD:S000002634	pathwaymech:enables	gomodel:ADENYL-KIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:ADENYL-KIN-RXN RO:0002333 gomodel:YDR226W-MONOMER_ADENYL-KIN-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/11; endpoint types: /individuals/0/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-013_e0987e330af0	gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_15378_ADENYLOSUCCINATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/12; endpoint types: /individuals/1/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-015_55e0096f695e	gomodel:AMPSYN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:AMPSYN-RXN BFO:0000066 gomodel:reaction_AMPSYN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/14; endpoint types: /individuals/2/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-016_08ee28c5c517	gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN	RO:0002234	CHEBI:57567	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_57567_ADENYLOSUCCINATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/15; endpoint types: /individuals/1/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-017_5601ba388707	gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN BFO:0000066 gomodel:reaction_ADENYLOSUCCINATE-SYNTHASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/16; endpoint types: /individuals/1/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-018_5a04341c61a9	gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN	RO:0002233	CHEBI:58053	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_58053_ADENYLOSUCCINATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/17; endpoint types: /individuals/1/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-019_a5ea5a43282f	gomodel:AMPSYN-RXN	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:AMPSYN-RXN RO:0002234 gomodel:CHEBI_456215_AMPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/18; endpoint types: /individuals/2/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-020_11bc122ca53a	gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_43474_ADENYLOSUCCINATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/19; endpoint types: /individuals/1/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-021_73b3d64c6581	gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN	RO:0002234	CHEBI:58189	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_58189_ADENYLOSUCCINATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/20; endpoint types: /individuals/1/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-022_b6661e71fa3b	gomodel:ADENYL-KIN-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:ADENYL-KIN-RXN RO:0002234 gomodel:CHEBI_456216_ADENYL-KIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/21; endpoint types: /individuals/0/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-023_00ab00cab1e6	gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN	RO:0002233	CHEBI:37565	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_37565_ADENYLOSUCCINATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/22; endpoint types: /individuals/1/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-024_56916e6696f5	gomodel:AMPSYN-RXN	RO:0002233	CHEBI:57567	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:AMPSYN-RXN RO:0002233 gomodel:CHEBI_57567_ADENYLOSUCCINATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/23; endpoint types: /individuals/2/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-025_2ef39b9b7277	gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN	RO:0002233	CHEBI:29991	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:ADENYLOSUCCINATE-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_29991_ADENYLOSUCCINATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/24; endpoint types: /individuals/1/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-026_045f5b97f6ce	gomodel:YeastPathways_PWY-7219/6a4c244800000590	BFO:0000050	GO:0046086	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7219/6a4c244800000590 BFO:0000050 gomodel:YeastPathways_PWY-7219/YeastPathways_PWY-7219."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/25; endpoint types: /individuals/40/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_edge-027_10ebd37e56b0	SGD:S000004351	pathwaymech:enables	gomodel:AMPSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7219		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7219"", ""source_assertion"": ""The model asserts gomodel:AMPSYN-RXN RO:0002333 gomodel:YLR359W-MONOMER_AMPSYN-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-7219.json#/facts/26; endpoint types: /individuals/2/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7219"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7219.json"", ""title"": ""GO-CAM adenosine ribonucleotides de novo biosynthesis model YeastPathways_PWY-7219"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_location-91a1b562aa6f_0a7927ec1163	SGD:S000005164	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P80210	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03125); ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P80210"", ""source_assertion"": ""UniProtKB:P80210 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2353/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P80210"", ""source_assertion"": ""UniProtKB:P80210 has the exact SGD cross-reference SGD:S000005164."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2353/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P80210"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P80210 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_location-a619511964fc_089f0651883a	SGD:S000000972	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26364	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03169); ECO:0000269 (PubMed:1620094)	"[{""reference_id"": ""UniProtKB:P26364"", ""source_assertion"": ""UniProtKB:P26364 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/745/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P26364"", ""source_assertion"": ""UniProtKB:P26364 has the exact SGD cross-reference SGD:S000000972."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/745/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P26364"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P26364 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_location-9c72ff68b985_2df2dd9bf3f4	SGD:S000002634	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07170	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03168); ECO:0000269 (PubMed:12045196); ECO:0000269 (PubMed:2850178) Source qualification: 90% cytoplasmic, 10% mitochondrial	"[{""reference_id"": ""UniProtKB:P07170"", ""source_assertion"": ""UniProtKB:P07170 annotates location Cytoplasm, cytosol (SL-0091)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/157/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07170"", ""source_assertion"": ""UniProtKB:P07170 has the exact SGD cross-reference SGD:S000002634."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/157/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07170"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07170 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_location-0f44a54831cc_3a782e48badf	SGD:S000002634	RO:0001025	GO:0005758	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07170	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03168); ECO:0000269 (PubMed:12045196); ECO:0000269 (PubMed:16823961); ECO:0000269 (PubMed:22984289); ECO:0000269 (PubMed:2850178) Source qualification: 90% cytoplasmic, 10% mitochondrial	"[{""reference_id"": ""UniProtKB:P07170"", ""source_assertion"": ""UniProtKB:P07170 annotates location Mitochondrion intermembrane space (SL-0169)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/157/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07170"", ""source_assertion"": ""UniProtKB:P07170 has the exact SGD cross-reference SGD:S000002634."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/157/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07170"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07170 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_function-a85609c5ad19_c65e52d18515	gomodel:YeastPathways_PWY-7219/6a4c244800000590	RO:0002233	CHEBI:37565	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26364	Reviewed ADK2 uses GTP, not ATP, to phosphorylate AMP; native instance retained.	"[{""reference_id"": ""UniProtKB:P26364"", ""source_assertion"": ""a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP"", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/P26364.json [sha256:6f63766ee236ebf46d0823f592d7405d0c8fbec5c26ef084abcdbd93762cb44d] #/comments/1/reaction""}, {""reference_id"": ""UniProtKB:P26364"", ""source_assertion"": ""ADK2 has GTP:AMP and ITP:AMP phosphotransferase activity and does not accept ATP as phosphate donor. This branch represents its GTP reaction."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/P26364.json [sha256:6f63766ee236ebf46d0823f592d7405d0c8fbec5c26ef084abcdbd93762cb44d] #/comments/0/texts/0""}]"	"[{""id"": ""UniProtKB:P26364"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P26364 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_function-ec4f392dad87_029eb7707c15	gomodel:YeastPathways_PWY-7219/6a4c244800000590	RO:0002233	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26364	Reviewed ADK2 uses GTP, not ATP, to phosphorylate AMP; native instance retained.	"[{""reference_id"": ""UniProtKB:P26364"", ""source_assertion"": ""a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP"", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/P26364.json [sha256:6f63766ee236ebf46d0823f592d7405d0c8fbec5c26ef084abcdbd93762cb44d] #/comments/1/reaction""}, {""reference_id"": ""UniProtKB:P26364"", ""source_assertion"": ""ADK2 has GTP:AMP and ITP:AMP phosphotransferase activity and does not accept ATP as phosphate donor. This branch represents its GTP reaction."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/P26364.json [sha256:6f63766ee236ebf46d0823f592d7405d0c8fbec5c26ef084abcdbd93762cb44d] #/comments/0/texts/0""}]"	"[{""id"": ""UniProtKB:P26364"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P26364 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_function-e3707d72983a_d9495cfe2ac2	gomodel:YeastPathways_PWY-7219/6a4c244800000590	RO:0002234	CHEBI:58189	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26364	Reviewed ADK2 uses GTP, not ATP, to phosphorylate AMP; native instance retained.	"[{""reference_id"": ""UniProtKB:P26364"", ""source_assertion"": ""a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP"", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/P26364.json [sha256:6f63766ee236ebf46d0823f592d7405d0c8fbec5c26ef084abcdbd93762cb44d] #/comments/1/reaction""}, {""reference_id"": ""UniProtKB:P26364"", ""source_assertion"": ""ADK2 has GTP:AMP and ITP:AMP phosphotransferase activity and does not accept ATP as phosphate donor. This branch represents its GTP reaction."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/P26364.json [sha256:6f63766ee236ebf46d0823f592d7405d0c8fbec5c26ef084abcdbd93762cb44d] #/comments/0/texts/0""}]"	"[{""id"": ""UniProtKB:P26364"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P26364 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_function-d69271e04bb8_f2a4dcbec4e7	gomodel:YeastPathways_PWY-7219/6a4c244800000590	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26364	Reviewed ADK2 uses GTP, not ATP, to phosphorylate AMP; native instance retained.	"[{""reference_id"": ""UniProtKB:P26364"", ""source_assertion"": ""a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP"", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/P26364.json [sha256:6f63766ee236ebf46d0823f592d7405d0c8fbec5c26ef084abcdbd93762cb44d] #/comments/1/reaction""}, {""reference_id"": ""UniProtKB:P26364"", ""source_assertion"": ""ADK2 has GTP:AMP and ITP:AMP phosphotransferase activity and does not accept ATP as phosphate donor. This branch represents its GTP reaction."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/P26364.json [sha256:6f63766ee236ebf46d0823f592d7405d0c8fbec5c26ef084abcdbd93762cb44d] #/comments/0/texts/0""}]"	"[{""id"": ""UniProtKB:P26364"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P26364 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7219_cofactor-df279653d2ae_f1a24d454df4	SGD:S000005164	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P80210	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03125) Binds 1 Mg(2+) ion per subunit. UniProt note evidence: ECO:0000255 (HAMAP-Rule:MF_03125)	"[{""reference_id"": ""UniProtKB:P80210"", ""source_assertion"": ""UniProtKB:P80210 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2353/comments/0/cofactors/0; /results/2353/comments/0/note""}, {""reference_id"": ""UniProtKB:P80210"", ""source_assertion"": ""UniProtKB:P80210 has the exact SGD cross-reference SGD:S000005164."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2353/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P80210"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P80210 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-001_32f47b40a204	CHEBI:15890	pathwaymech:consumes	RHEA:11197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11197		"[{""reference_id"": ""RHEA:11197"", ""source_assertion"": ""Rhea RHEA:11197 assigns CHEBI:15890 to its substrates with coefficient 1; the exact charged species is linked through rh:compound/rh:chebi."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11197']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/11196_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_11196_compound_2241']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:11197"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 11197 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-002_136b876be101	CHEBI:57502	pathwaymech:consumes	RHEA:11197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11197		"[{""reference_id"": ""RHEA:11197"", ""source_assertion"": ""Rhea RHEA:11197 assigns CHEBI:57502 to its substrates with coefficient 1; the exact charged species is linked through rh:compound/rh:chebi."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11197']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/11196_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_11196_compound_2274']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:11197"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 11197 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-003_3337b4f80ef7	RHEA:11197	pathwaymech:produces	CHEBI:57918	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11197		"[{""reference_id"": ""RHEA:11197"", ""source_assertion"": ""Rhea RHEA:11197 assigns CHEBI:57918 to its products with coefficient 1; the exact charged species is linked through rh:compound/rh:chebi."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11197']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/11196_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_11196_compound_1950']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:11197"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 11197 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-004_fb981470c57e	RHEA:11197	pathwaymech:produces	CHEBI:32544	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11197		"[{""reference_id"": ""RHEA:11197"", ""source_assertion"": ""Rhea RHEA:11197 assigns CHEBI:32544 to its products with coefficient 1; the exact charged species is linked through rh:compound/rh:chebi."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11197']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/11196_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_11196_compound_2096']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:11197"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 11197 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-005_cd21c22c8ab5	RHEA:11197	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11197		"[{""reference_id"": ""RHEA:11197"", ""source_assertion"": ""Rhea RHEA:11197 assigns CHEBI:15378 to its products with coefficient 1; the exact charged species is linked through rh:compound/rh:chebi."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11197']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/11196_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_11196_compound_3249']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:11197"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 11197 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-006_c563ae3aac38	CHEBI:57918	pathwaymech:consumes	RHEA:23561	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23561		"[{""reference_id"": ""RHEA:23561"", ""source_assertion"": ""Rhea RHEA:23561 assigns CHEBI:57918 to its substrates with coefficient 1; the exact charged species is linked through rh:compound/rh:chebi."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23561']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/23560_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_23560_compound_1950']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:23561"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 23561 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-007_92031f38ba55	CHEBI:60487	pathwaymech:consumes	RHEA:23561	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23561		"[{""reference_id"": ""RHEA:23561"", ""source_assertion"": ""Rhea RHEA:23561 assigns CHEBI:60487 to its substrates with coefficient 1; the exact charged species is linked through rh:compound/rh:chebi."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23561']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/23560_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_23560_compound_6530']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:23561"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 23561 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-008_cbc2535289c9	RHEA:23561	pathwaymech:produces	CHEBI:60493	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23561		"[{""reference_id"": ""RHEA:23561"", ""source_assertion"": ""Rhea RHEA:23561 assigns CHEBI:60493 to its products with coefficient 1; the exact charged species is linked through rh:compound/rh:chebi."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23561']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/23560_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_23560_compound_6640']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:23561"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 23561 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-009_7e309e98f0b8	RHEA:23561	pathwaymech:produces	CHEBI:58115	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23561		"[{""reference_id"": ""RHEA:23561"", ""source_assertion"": ""Rhea RHEA:23561 assigns CHEBI:58115 to its products with coefficient 1; the exact charged species is linked through rh:compound/rh:chebi."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23561']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/23560_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_23560_compound_3807']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:23561"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 23561 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-010_22a2e1208539	RHEA:23561	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23561		"[{""reference_id"": ""RHEA:23561"", ""source_assertion"": ""Rhea RHEA:23561 assigns CHEBI:15378 to its products with coefficient 1; the exact charged species is linked through rh:compound/rh:chebi."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23561']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/23560_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_23560_compound_3249']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:23561"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 23561 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-011_c5e593405708	CHEBI:60493	pathwaymech:consumes	RHEA:30368	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30368		"[{""reference_id"": ""RHEA:30368"", ""source_assertion"": ""Rhea RHEA:30368 assigns CHEBI:60493 to its substrates with coefficient 1; the exact charged species is linked through rh:compound/rh:chebi."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30368']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/30367_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_30367_compound_6640']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:30368"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 30368 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-012_f2b43a41536d	CHEBI:15377	pathwaymech:consumes	RHEA:30368	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30368		"[{""reference_id"": ""RHEA:30368"", ""source_assertion"": ""Rhea RHEA:30368 assigns CHEBI:15377 to its substrates with coefficient 1; the exact charged species is linked through rh:compound/rh:chebi."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30368']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/30367_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_30367_compound_1283']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:30368"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 30368 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-013_007af6bfe8ea	RHEA:30368	pathwaymech:produces	CHEBI:18408	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30368		"[{""reference_id"": ""RHEA:30368"", ""source_assertion"": ""Rhea RHEA:30368 assigns CHEBI:18408 to its products with coefficient 1; the exact charged species is linked through rh:compound/rh:chebi."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30368']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/30367_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_30367_compound_4165']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:30368"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 30368 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-014_92cd8184d9a5	RHEA:30368	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30368		"[{""reference_id"": ""RHEA:30368"", ""source_assertion"": ""Rhea RHEA:30368 assigns CHEBI:43474 to its products with coefficient 1; the exact charged species is linked through rh:compound/rh:chebi."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30368']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/30367_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_30367_compound_5518']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:30368"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 30368 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-015_9e6cace42b8b	PathBank:SMP0001898/ProteinComplex/3870	pathwaymech:catalyzes	RHEA:11197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-023-40932-4|PathBank:SMP0001898|UniProtKB:P36562	The native catalyst is represented as its CobT assembly, with the homodimer assignment qualified by similarity on the membership edge. The engineered 2023 system supports MG1655 enzyme function without establishing its native quaternary structure or physiological flux. The supplement misabbreviates nicotinate ribonucleotide as NMN; exact chemistry follows inspected Rhea and reviewed UniProt.	"[{""reference_id"": ""PathBank:SMP0001898"", ""source_assertion"": ""Native ReactionCatalysis/5115 uses ProteinComplex/3870 as controller of Reactions/5142, the DMB plus nicotinate-ribonucleotide reaction producing alpha-ribazole phosphate, nicotinate and a proton."", ""source_locator"": ""PW001884.owl: bp:Catalysis[@rdf:ID=\""ReactionCatalysis/5115\""]/bp:controller; bp:controlled; bp:BiochemicalReaction[@rdf:ID=\""Reactions/5142\""]/bp:left; bp:right; bp:name""}, {""reference_id"": ""UniProtKB:P36562"", ""source_assertion"": ""Reviewed K-12 CobT P36562 assigns DMB plus nicotinate beta-D-ribonucleotide to alpha-ribazole 5'-phosphate, nicotinate and H(+), with RHEA:11196. The reaction comment has no inline experimental qualifier."", ""source_locator"": ""/primaryAccession; /organism/taxonId; /comments/0; /comments/1/reaction""}, {""reference_id"": ""DOI:10.1038/s41467-023-40932-4"", ""source_assertion"": ""The 2023 supplement identifies the CobT used in the engineered cell-free B12 synthesis system as E. coli MG1655 EC 2.4.2.21. This supports use of the MG1655 enzyme in a multienzyme system, not direct characterization of its dimer."", ""source_locator"": ""Supplementary Information, Supplementary Table 1, PDF page 4; Supplementary Table 2, PDF pages 7-9; main paper Methods, Cloning and purification of enzymes""}]"	"[{""id"": ""DOI:10.1038/s41467-023-40932-4"", ""source_sha256"": ""b847c84fe5bf0b7de306cba3cb3c0ee8278053381a8dafaa35789dfcfa57dce7"", ""source_version"": ""Published Supplementary Information; retrieved 2026-10-11 UTC"", ""title"": ""Supplementary Information for A synthetic cell-free 36-enzyme reaction system for vitamin B12 production."", ""url"": ""https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41467-023-40932-4/MediaObjects/41467_2023_40932_MOESM3_ESM.pdf""}, {""id"": ""PathBank:SMP0001898"", ""source_sha256"": ""4b4233814e281b298cf718f03ae89c2c0af8e70a278ccd0ea0664d8575499612"", ""source_version"": ""Preserved primary BioPAX archive member PW001884.owl; digest covers member bytes"", ""title"": ""Adenosylcobalamin Salvage from Cobinamide: native CobT assembly and reaction projection"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P36562"", ""source_sha256"": ""d1367904ff45c42a0e02ab1aead789089b6f65f0cb1927084c6683d59a88dbad"", ""source_version"": ""2026_03; response release header; retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P36562"", ""url"": ""https://rest.uniprot.org/uniprotkb/P36562.json""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-016_e706ca48d3b1	UniProtKB:P36562	BFO:0000050	PathBank:SMP0001898/ProteinComplex/3870	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0001898|UniProtKB:P36562	Membership retains the native dimer coefficient without upgrading a similarity annotation to an experimentally established K-12 quaternary structure.	"[{""reference_id"": ""PathBank:SMP0001898"", ""source_assertion"": ""ProteinComplex/3870 contains Protein/6552 with coefficient 2.0. Protein/6552 resolves through ProteinReference/6552 and Reference/UniProt_P36562 to accession P36562."", ""source_locator"": ""PW001884.owl: bp:Complex[@rdf:ID=\""ProteinComplex/3870\""]/bp:component; bp:componentStoichiometry; bp:Stoichiometry[@rdf:ID=\""Protein/6552/Stoichiometry/2.0\""]; bp:ProteinReference[@rdf:ID=\""ProteinReference/6552\""]/bp:xref; bp:UnificationXref[@rdf:ID=\""Reference/UniProt_P36562\""]""}, {""reference_id"": ""UniProtKB:P36562"", ""source_assertion"": ""Reviewed CobT is annotated as a homodimer with ECO:0000250, an inference by similarity."", ""source_locator"": ""/comments/3/commentType; /comments/3/texts/0/value; /comments/3/texts/0/evidences/0/evidenceCode""}]"	"[{""id"": ""PathBank:SMP0001898"", ""source_sha256"": ""4b4233814e281b298cf718f03ae89c2c0af8e70a278ccd0ea0664d8575499612"", ""source_version"": ""Preserved primary BioPAX archive member PW001884.owl; digest covers member bytes"", ""title"": ""Adenosylcobalamin Salvage from Cobinamide: native CobT assembly and reaction projection"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P36562"", ""source_sha256"": ""d1367904ff45c42a0e02ab1aead789089b6f65f0cb1927084c6683d59a88dbad"", ""source_version"": ""2026_03; response release header; retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P36562"", ""url"": ""https://rest.uniprot.org/uniprotkb/P36562.json""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-017_2032e5f7f89a	UniProtKB:P36561	pathwaymech:enables	RHEA:23561	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-023-40932-4|MetaCyc:COBS-MONOMER|PMID:31609521|PMID:34031037|PMID:37620358|PMID:7592411|UniProtKB:P36561	This gene-product/activity edge retains the reviewed K-12 assignment without asserting a physical monomer catalyst. The 2021 construct is BL21-derived; the 2023 work separately supports engineered MG1655 CobS function. Cyanation during product analysis limits inference about the native upper ligand from the final peak. The 2023 supplement misnames the product as adenosylcobinamide-5-P; the independently balanced Rhea equation is retained. No direct E. coli cobamide-remodeling activity is assigned.	"[{""reference_id"": ""UniProtKB:P36561"", ""source_assertion"": ""Reviewed K-12 CobS includes the alpha-ribazole 5'-phosphate plus adenosylcobinamide-GDP reaction RHEA:23560. Its FUNCTION comment explicitly qualifies this synthesis by similarity (ECO:0000250)."", ""source_locator"": ""/primaryAccession; /organism/taxonId; /comments/0; /comments/2/reaction""}, {""reference_id"": ""MetaCyc:COBS-MONOMER"", ""source_assertion"": ""COBS-MONOMER maps to P36561 and catalyzes COBALAMIN5PSYN-RXN through COBALAMIN5PSYN-ENZRXN. The native comment cites Salmonella terminal-step reassessment for the function."", ""source_locator"": ""Protein[@frameid=\""COBS-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]; catalyzes/Enzymatic-Reaction[@frameid=\""COBALAMIN5PSYN-ENZRXN\""]; comment""}, {""reference_id"": ""PMID:7592411"", ""source_assertion"": ""E. coli K-12 cobS mutants failed the cobinamide-dependent growth test even with DMB supplementation. This supports salvage function, not a purified assay of each current Rhea species."", ""source_locator"": ""PMC177486: Results, Localization of mutations within the E. coli cob operon; Tables 2 and 3, printed page 6375; Materials and Methods, strain and cloning scope""}, {""reference_id"": ""PMID:34031037"", ""source_assertion"": ""EcCobS-containing membranes supported the cobinamide-salvaging control with alpha-ribazole phosphate, Salmonella CobU and Vibrio CobC. The experiment used a BL21-derived host and does not assay K-12 CobC."", ""source_locator"": ""PMC8407341: Results, In vitro reactions for VcCobS remodeling; Figure 4A; Table 1; Materials and Methods, In vitro cobamide production assays""}, {""reference_id"": ""PMID:31609521"", ""source_assertion"": ""The EcCobS expression construct was cloned from BL21. This identifies the origin of the construct subsequently cited in the 2021 paper; exact equivalence to K-12 accession P36561 is not established here."", ""source_locator"": ""Experimental procedures, Strain cultivation and cloning, second paragraph; pET16b EcCobS construct""}, {""reference_id"": ""PMID:37620358"", ""source_assertion"": ""The 2023 study cloned CobS from E. coli MG1655, fused it to ApoAI* and signal-peptide-deleted MBP for the SIMPLEx system, and tested engineered B12 production and a cell-free cascade. This is an MG1655 construct with engineered solubilization, not a native membrane assembly assay."", ""source_locator"": ""PMC10449867: Results, Promoting the reactions catalyzed by transmembrane enzymes; Methods, Cloning and purification of enzymes; Supplementary Figure 9d""}, {""reference_id"": ""DOI:10.1038/s41467-023-40932-4"", ""source_assertion"": ""Supplementary Table 1 identifies CobS as E. coli MG1655 EC 2.7.8.26; Supplementary Figure 9d compares the engineered B16 parent, cobS deletion, and CobS or SIMPLEx-CobS complementation. Its reaction product name is inconsistent with the intended cobalamin-phosphate structure."", ""source_locator"": ""Supplementary Information, Supplementary Table 1, PDF page 4; Supplementary Figure 9d and legend, PDF page 23""}]"	"[{""id"": ""DOI:10.1038/s41467-023-40932-4"", ""source_sha256"": ""b847c84fe5bf0b7de306cba3cb3c0ee8278053381a8dafaa35789dfcfa57dce7"", ""source_version"": ""Published Supplementary Information; retrieved 2026-10-11 UTC"", ""title"": ""Supplementary Information for A synthetic cell-free 36-enzyme reaction system for vitamin B12 production."", ""url"": ""https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41467-023-40932-4/MediaObjects/41467_2023_40932_MOESM3_ESM.pdf""}, {""id"": ""MetaCyc:COBS-MONOMER"", ""source_sha256"": ""97b447af23a34ed1d87c1e8470ca626a0068ba750daa4552940269602600dd8f"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc COBS-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:COBS-MONOMER""}, {""id"": ""PMID:31609521"", ""source_version"": ""Publisher full text inspected through web tool 2026-10-11 UTC; no downloaded full-text body digest"", ""title"": ""Specificity of cobamide remodeling, uptake and utilization in Vibrio cholerae."", ""url"": ""https://onlinelibrary.wiley.com/doi/full/10.1111/mmi.14402""}, {""id"": ""PMID:34031037"", ""source_sha256"": ""c030fdc34f5fb84c0543d327c8ee0050cf288dfcc915a2f9305239bd1392d77d"", ""source_version"": ""Primary full text; retrieved 2026-10-10 UTC"", ""title"": ""Direct Cobamide Remodeling via Additional Function of Cobamide Biosynthesis Protein CobS from Vibrio cholerae."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC8407341/""}, {""id"": ""PMID:37620358"", ""source_sha256"": ""b672d2fa009658762fc8f41ccbd17fcbe943440b40353f7570c87651cee90f82"", ""source_version"": ""Primary full text; retrieved 2026-10-11 UTC"", ""title"": ""A synthetic cell-free 36-enzyme reaction system for vitamin B12 production."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC10449867/""}, {""id"": ""PMID:7592411"", ""source_sha256"": ""42da7e9bae0a77458a857218fe302469602a6e9247cb4e5092af60c362ad122b"", ""source_version"": ""Primary full text; retrieved 2026-10-10 UTC"", ""title"": ""The cobalamin (coenzyme B12) biosynthetic genes of Escherichia coli."", ""url"": ""https://europepmc.org/articles/PMC177486?pdf=render""}, {""id"": ""UniProtKB:P36561"", ""source_sha256"": ""af9140df9a25520426db89481572270d70fbc834fd3d79ecd122dec76edb2f98"", ""source_version"": ""2026_03; response release header; retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P36561"", ""url"": ""https://rest.uniprot.org/uniprotkb/P36561.json""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-018_3342d8b4ab0b	UniProtKB:P52086	pathwaymech:enables	RHEA:30368	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-023-40932-4|DOI:10.2210/pdb6E4B/pdb|MetaCyc:RIBAZOLEPHOSPHAT-MONOMER|PMID:17209023|UniProtKB:P52086	The reviewed K-12 annotation remains homology-qualified, with additional MG1655 functional support from the engineered 2023 multienzyme system. That system does not establish isolated CobC kinetics or native terminal-step physiology. Its supplement misnames the phosphate substrate and calls CobC[4] a synthase; exact chemistry follows independent Rhea and reviewed annotation. The P52086-linked 6E4B dimer is structurally assigned without solution-assembly evidence. No physical monomer state is inferred from the database frame name.	"[{""reference_id"": ""UniProtKB:P52086"", ""source_assertion"": ""Reviewed K-12 CobC assigns adenosylcobalamin 5'-phosphate hydrolysis to RHEA:30367, with ECO:0000250 and UniProtKB:P39701 as the homology source."", ""source_locator"": ""/primaryAccession; /organism/taxonId; /comments/0; /comments/1/reaction/evidences""}, {""reference_id"": ""MetaCyc:RIBAZOLEPHOSPHAT-MONOMER"", ""source_assertion"": ""The version-22.5 P52086 frame describes E. coli K-12 CobC as uncharacterized and predicts its phosphatase function by Salmonella homology. This historical source statement does not account for the subsequently inspected 2023 engineered MG1655 system."", ""source_locator"": ""Protein[@frameid=\""RIBAZOLEPHOSPHAT-MONOMER\""]/comment; dblink[dblink-db=\""UNIPROT\""]; catalyzes/Enzymatic-Reaction[@frameid=\""ENZRXN0-7469\""]""}, {""reference_id"": ""PMID:17209023"", ""source_assertion"": ""Salmonella Typhimurium cobC mutants accumulated cobalamin phosphate; the paper assigns terminal dephosphorylation to CobC and explicitly limits this physiological conclusion to that organism."", ""source_locator"": ""PMC1899380: Results, A cobC strain accumulates AdoCbl-P; Figures 5 and 6; Discussion, opening paragraph; Figure 8""}, {""reference_id"": ""DOI:10.1038/s41467-023-40932-4"", ""source_assertion"": ""Supplementary Table 1 identifies the CobC phosphatase used in the 2023 cell-free system as E. coli MG1655 EC 3.1.3.73. Table 2 includes this enzyme as CobC[4]. This is multienzyme-system support, not isolated CobC kinetics; the reported K′eq column is calculated thermodynamics."", ""source_locator"": ""Supplementary Information, Supplementary Table 1, PDF pages 2 and 5-6; Supplementary Table 2 and footnote [4], PDF pages 7-9; main paper Methods, Cloning and purification of enzymes""}, {""reference_id"": ""DOI:10.2210/pdb6E4B/pdb"", ""source_assertion"": ""RCSB assembly 1 for 6E4B is an author-and-PISA-defined dimer. The author-evidence field explicitly reports experimental_support as none; this does not establish a separately measured solution oligomerization state."", ""source_locator"": ""RCSB core assembly/6E4B/1 JSON: /pdbx_struct_assembly; /pdbx_struct_assembly_auth_evidence/0/experimental_support; /rcsb_assembly_info""}]"	"[{""id"": ""DOI:10.1038/s41467-023-40932-4"", ""source_sha256"": ""b847c84fe5bf0b7de306cba3cb3c0ee8278053381a8dafaa35789dfcfa57dce7"", ""source_version"": ""Published Supplementary Information; retrieved 2026-10-11 UTC"", ""title"": ""Supplementary Information for A synthetic cell-free 36-enzyme reaction system for vitamin B12 production."", ""url"": ""https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41467-023-40932-4/MediaObjects/41467_2023_40932_MOESM3_ESM.pdf""}, {""id"": ""DOI:10.2210/pdb6E4B/pdb"", ""source_sha256"": ""53d35b7f80a5302e9d99389ff4196dceb0bbbe4d6e30c2f5ca91ca500515d5fd"", ""source_version"": ""RCSB current API response; entry revision 1.2 (2023-10-11); retrieved 2026-10-11 UTC"", ""title"": ""RCSB PDB 6E4B biological assembly 1: putative alpha-ribazole-5-phosphate phosphatase from Escherichia coli K-12."", ""url"": ""https://data.rcsb.org/rest/v1/core/assembly/6E4B/1""}, {""id"": ""MetaCyc:RIBAZOLEPHOSPHAT-MONOMER"", ""source_sha256"": ""f961df8173c4986ed62c12c0a5afa548ef85476c56dd5bb8cd2f5cadf806d16c"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc RIBAZOLEPHOSPHAT-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RIBAZOLEPHOSPHAT-MONOMER""}, {""id"": ""PMID:17209023"", ""source_sha256"": ""9799f9e02b3cb36da51360533d3a8ef651693c3e1cdd232b32d50ecf16d83bdf"", ""source_version"": ""Primary full text; retrieved 2026-10-10 UTC"", ""title"": ""Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5'-phosphate by the CobC phosphatase is the last step of the pathway."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1899380/""}, {""id"": ""UniProtKB:P52086"", ""source_sha256"": ""0b52f469e0f7f25af8b06610db8fa168d5b78114f9a794f1b9ac3af0ae7f63f0"", ""source_version"": ""2026_03; response release header; retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P52086"", ""url"": ""https://rest.uniprot.org/uniprotkb/P52086.json""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-019_77ea489b2329	UniProtKB:P36561	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36561	The magnesium requirement is retained as a similarity-qualified annotation. MgCl2 in the inspected reaction mixtures is an assay condition and is not an independent apo-enzyme metal-reconstitution or binding experiment.	"[{""reference_id"": ""UniProtKB:P36561"", ""source_assertion"": ""Reviewed CobS names Mg(2+) as cofactor, linked to CHEBI:18420, with ECO:0000250."", ""source_locator"": ""/comments/3/commentType; /comments/3/cofactors/0""}]"	"[{""id"": ""UniProtKB:P36561"", ""source_sha256"": ""af9140df9a25520426db89481572270d70fbc834fd3d79ecd122dec76edb2f98"", ""source_version"": ""2026_03; response release header; retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P36561"", ""url"": ""https://rest.uniprot.org/uniprotkb/P36561.json""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-020_5aba111f6a44	UniProtKB:P36561	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36561	This retains the reviewed location assertion. The 2005 cited paper was inspected at abstract level; no detailed membrane topology or exclusive localization of every molecule is inferred.	"[{""reference_id"": ""UniProtKB:P36561"", ""source_assertion"": ""Reviewed P36561 has cell-inner-membrane, multipass annotation with ECO:0000269 citing PMID:15919996, and an explicit GO:0005886 cross-reference with IDA:EcoCyc and ECO:0000314."", ""source_locator"": ""/comments/5/subcellularLocations/0; /uniProtKBCrossReferences/32""}]"	"[{""id"": ""UniProtKB:P36561"", ""source_sha256"": ""af9140df9a25520426db89481572270d70fbc834fd3d79ecd122dec76edb2f98"", ""source_version"": ""2026_03; response release header; retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P36561"", ""url"": ""https://rest.uniprot.org/uniprotkb/P36561.json""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-021_e345dc0df7ba	RHEA:11197	BFO:0000050	MetaCyc:PWY-5509	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DMBPPRIBOSYLTRANS-RXN|MetaCyc:PWY-5509		"[{""reference_id"": ""MetaCyc:PWY-5509"", ""source_assertion"": ""PWY-5509 lists DMBPPRIBOSYLTRANS-RXN as a member and selects L2R in reaction-layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-5509\""]/reaction-list/Reaction[@frameid=\""DMBPPRIBOSYLTRANS-RXN\""]; reaction-layout[Reaction[@frameid=\""DMBPPRIBOSYLTRANS-RXN\""]]""}, {""reference_id"": ""MetaCyc:DMBPPRIBOSYLTRANS-RXN"", ""source_assertion"": ""DMBPPRIBOSYLTRANS-RXN supplies the matching chemical sides and the directional RHEA:11197 cross-reference."", ""source_locator"": ""Reaction/left; right; reaction-direction; dblink[dblink-db=\""RHEA\""]""}]"	"[{""id"": ""MetaCyc:DMBPPRIBOSYLTRANS-RXN"", ""source_sha256"": ""f4ee1227bb9c0a7ca91a8e9d99de08f1e4283d196c15e147f9573ce72a3e6394"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc DMBPPRIBOSYLTRANS-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DMBPPRIBOSYLTRANS-RXN""}, {""id"": ""MetaCyc:PWY-5509"", ""source_sha256"": ""de4e4e21ac728af6ed447d0d42e2b018b1fdeab29cc1062604108bfb3d2e7244"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc PWY-5509"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5509""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-022_53b29bdb3885	RHEA:23561	BFO:0000050	MetaCyc:PWY-5509	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:COBALAMIN5PSYN-RXN|MetaCyc:PWY-5509		"[{""reference_id"": ""MetaCyc:PWY-5509"", ""source_assertion"": ""PWY-5509 lists COBALAMIN5PSYN-RXN as a member and selects L2R in reaction-layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-5509\""]/reaction-list/Reaction[@frameid=\""COBALAMIN5PSYN-RXN\""]; reaction-layout[Reaction[@frameid=\""COBALAMIN5PSYN-RXN\""]]""}, {""reference_id"": ""MetaCyc:COBALAMIN5PSYN-RXN"", ""source_assertion"": ""COBALAMIN5PSYN-RXN supplies the matching chemical sides and the directional RHEA:23561 cross-reference."", ""source_locator"": ""Reaction/left; right; reaction-direction; dblink[dblink-db=\""RHEA\""]""}]"	"[{""id"": ""MetaCyc:COBALAMIN5PSYN-RXN"", ""source_sha256"": ""f2efa5db8aad7f08f126e43f56ccc3603c1107f990f1e96dd70a2eb517ec1843"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc COBALAMIN5PSYN-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:COBALAMIN5PSYN-RXN""}, {""id"": ""MetaCyc:PWY-5509"", ""source_sha256"": ""de4e4e21ac728af6ed447d0d42e2b018b1fdeab29cc1062604108bfb3d2e7244"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc PWY-5509"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5509""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-023_46335096d7eb	RHEA:30368	BFO:0000050	MetaCyc:PWY-5509	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5509|MetaCyc:RXN-8770|RHEA:30368		"[{""reference_id"": ""MetaCyc:PWY-5509"", ""source_assertion"": ""PWY-5509 lists RXN-8770 as a member and selects L2R in reaction-layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-5509\""]/reaction-list/Reaction[@frameid=\""RXN-8770\""]; reaction-layout[Reaction[@frameid=\""RXN-8770\""]]""}, {""reference_id"": ""MetaCyc:RXN-8770"", ""source_assertion"": ""RXN-8770 supplies the hydrolysis sides, a bidirectional RHEA:30370 cross-reference and a PHYSIOL-LEFT-TO-RIGHT direction. Selection of RHEA:30368 additionally uses the separately cited Rhea family."", ""source_locator"": ""Reaction/left; right; reaction-direction; dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:30368"", ""source_assertion"": ""Rhea master 30367 links bidirectional reaction 30370 and directional reaction 30368. Reaction 30368 consumes master side 30367_L and produces 30367_R, selecting the hydrolysis direction that matches native RXN-8770."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/30367\""]/rh:bidirectionalReaction; rh:directionalReaction; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/30368\""]/rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5509"", ""source_sha256"": ""de4e4e21ac728af6ed447d0d42e2b018b1fdeab29cc1062604108bfb3d2e7244"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc PWY-5509"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5509""}, {""id"": ""MetaCyc:RXN-8770"", ""source_sha256"": ""fcbdc14cb69887cc5b3c3f8edd25861e7ba453492b4781d2304acd92b395dadb"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc RXN-8770"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8770""}, {""id"": ""RHEA:30368"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 30368 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-024_1ab14ae87309	RHEA:11197	RO:0002413	RHEA:23561	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5509|PMID:10518530	The material-transfer edge represents the native annotated route. The cited 1999 reconstitution uses Salmonella enzymes; the later MG1655 proteins occur in a larger engineered multienzyme system, not an isolated native three-enzyme physiological-flux assay.	"[{""reference_id"": ""MetaCyc:PWY-5509"", ""source_assertion"": ""PWY-5509 orders DMBPPRIBOSYLTRANS-RXN before COBALAMIN5PSYN-RXN. Alpha-ribazole 5'-phosphate is the first reaction's product and the second reaction's substrate."", ""source_locator"": ""Pathway[@frameid=\""PWY-5509\""]/reaction-ordering[Reaction[@frameid=\""COBALAMIN5PSYN-RXN\""]]/predecessor-reactions; reaction-layout""}, {""reference_id"": ""PMID:10518530"", ""source_assertion"": ""The Salmonella enzyme reconstitution uses the CobT product alpha-ribazole 5'-phosphate with adenosylcobinamide-GDP for CobS-dependent formation of cobalamin phosphate."", ""source_locator"": ""PMC18366: Results, The CobS Protein Has Cobalamin Synthase Activity; Isolation of Products from the NLA and Cobalamin Synthase Reactions; Figures 3C and 4""}]"	"[{""id"": ""MetaCyc:PWY-5509"", ""source_sha256"": ""de4e4e21ac728af6ed447d0d42e2b018b1fdeab29cc1062604108bfb3d2e7244"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc PWY-5509"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5509""}, {""id"": ""PMID:10518530"", ""source_sha256"": ""e1879357ff7b981378c747cd9b687afa618f4cc71ab9d0d9982ae4b37c1339dd"", ""source_version"": ""Primary full text; retrieved 2026-10-10 UTC"", ""title"": ""In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC18366/""}]"	""
pathwaymech:MetaCyc_PWY-5509_nla-edge-025_ef7b868a3e5f	RHEA:23561	RO:0002413	RHEA:30368	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5509|PMID:10518530|PMID:17209023	This sequence is the selected reviewed E. coli annotation with explicit cross-species inference in the CobC annotation and later engineered MG1655 system support. The earlier 1999 in vitro paper alone did not establish the physiological timing of phosphate removal; the 2007 reassessment establishes it specifically in Salmonella.	"[{""reference_id"": ""MetaCyc:PWY-5509"", ""source_assertion"": ""PWY-5509 orders RXN-8770 after COBALAMIN5PSYN-RXN through the adenosylcobalamin 5'-phosphate intermediate."", ""source_locator"": ""Pathway[@frameid=\""PWY-5509\""]/reaction-ordering[Reaction[@frameid=\""RXN-8770\""]]/predecessor-reactions; reaction-layout""}, {""reference_id"": ""PMID:10518530"", ""source_assertion"": ""Salmonella CobC-containing extract dephosphorylated the cobalamin phosphate formed by nucleotide-loop assembly; vector-only extract did not. Corrinoids were cyanated before HPLC analysis."", ""source_locator"": ""PMC18366: Results, The CobC Protein Can Dephosphorylate AdoCbl-5'-P in Vitro; Figure 6""}, {""reference_id"": ""PMID:17209023"", ""source_assertion"": ""The later Salmonella study supports alpha-ribazole phosphate use by CobS followed by terminal CobC dephosphorylation. Its Discussion states that validity in other prokaryotes remains to be shown."", ""source_locator"": ""PMC1899380: Results, Alpha-RP is the preferred substrate of the AdoCbl-5'-P synthase (CobS) enzyme; Figure 7; Discussion, opening paragraph; Figure 8""}]"	"[{""id"": ""MetaCyc:PWY-5509"", ""source_sha256"": ""de4e4e21ac728af6ed447d0d42e2b018b1fdeab29cc1062604108bfb3d2e7244"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc PWY-5509"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5509""}, {""id"": ""PMID:10518530"", ""source_sha256"": ""e1879357ff7b981378c747cd9b687afa618f4cc71ab9d0d9982ae4b37c1339dd"", ""source_version"": ""Primary full text; retrieved 2026-10-10 UTC"", ""title"": ""In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC18366/""}, {""id"": ""PMID:17209023"", ""source_sha256"": ""9799f9e02b3cb36da51360533d3a8ef651693c3e1cdd232b32d50ecf16d83bdf"", ""source_version"": ""Primary full text; retrieved 2026-10-10 UTC"", ""title"": ""Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5'-phosphate by the CobC phosphatase is the last step of the pathway."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1899380/""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-001_ed51768c6de4	CHEBI:141013	pathwaymech:consumes	RHEA:57689	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57688	Coefficient 1 in the selected Rhea direction.	"[{""reference_id"": ""RHEA:57688"", ""source_assertion"": ""RHEA:57689 substrates contain CHEBI:141013 with coefficient 1; the compound is cob(II)inamide."", ""source_locator"": ""http://rdf.rhea-db.org/57689 rh:substrates; http://rdf.rhea-db.org/57688_L rh:contains1 http://rdf.rhea-db.org/Participant_57688_compound_14747; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:57688"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57688 and left-to-right 57689"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-002_a11abf54f084	RHEA-COMP:14743	pathwaymech:consumes	RHEA:57689	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57688	Coefficient 1 in the selected Rhea direction. This is a whole generic protein state, not its isolated reactive part or an identified E. coli sequence.	"[{""reference_id"": ""RHEA:57688"", ""source_assertion"": ""RHEA:57689 substrates contain GENERIC:14743 with coefficient 1; the compound is apo-[corrinoid adenosyltransferase]."", ""source_locator"": ""http://rdf.rhea-db.org/57689 rh:substrates; http://rdf.rhea-db.org/57688_L rh:contains1 http://rdf.rhea-db.org/Participant_57688_compound_14743; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:57688"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57688 and left-to-right 57689"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-003_19550c6abaf5	RHEA:57689	pathwaymech:produces	RHEA-COMP:14966	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57688	Coefficient 1 in the selected Rhea direction. This is a whole generic protein state, not its isolated reactive part or an identified E. coli sequence.	"[{""reference_id"": ""RHEA:57688"", ""source_assertion"": ""RHEA:57689 products contain GENERIC:14966 with coefficient 1; the compound is cob(II)inamide-[corrinoid adenosyltransferase]."", ""source_locator"": ""http://rdf.rhea-db.org/57689 rh:products; http://rdf.rhea-db.org/57688_R rh:contains1 http://rdf.rhea-db.org/Participant_57688_compound_14966; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:57688"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57688 and left-to-right 57689"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-004_a99616151799	RHEA-COMP:14966	pathwaymech:consumes	RHEA:57693	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57692	Coefficient 2 in the selected Rhea direction. This is a whole generic protein state, not its isolated reactive part or an identified E. coli sequence. The bound-corrinoid reduction can occur spontaneously; no separate reductase or specific physiological electron donor is assigned.	"[{""reference_id"": ""RHEA:57692"", ""source_assertion"": ""RHEA:57693 substrates contain GENERIC:14966 with coefficient 2; the compound is cob(II)inamide-[corrinoid adenosyltransferase]."", ""source_locator"": ""http://rdf.rhea-db.org/57693 rh:substrates; http://rdf.rhea-db.org/57692_L rh:contains2 http://rdf.rhea-db.org/Participant_57692_compound_14966; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:57692"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57692 and left-to-right 57693"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-005_13fbad945072	RHEA-COMP:10686	pathwaymech:consumes	RHEA:57693	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57692	Coefficient 1 in the selected Rhea direction. This is a whole generic protein state, not its isolated reactive part or an identified E. coli sequence. The bound-corrinoid reduction can occur spontaneously; no separate reductase or specific physiological electron donor is assigned.	"[{""reference_id"": ""RHEA:57692"", ""source_assertion"": ""RHEA:57693 substrates contain GENERIC:10686 with coefficient 1; the compound is reduced [electron-transfer flavoprotein]."", ""source_locator"": ""http://rdf.rhea-db.org/57693 rh:substrates; http://rdf.rhea-db.org/57692_L rh:contains1 http://rdf.rhea-db.org/Participant_57692_compound_10686; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:57692"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57692 and left-to-right 57693"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-006_2b07b6ff0212	RHEA:57693	pathwaymech:produces	RHEA-COMP:16964	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57692	Coefficient 2 in the selected Rhea direction. This is a whole generic protein state, not its isolated reactive part or an identified E. coli sequence. The bound-corrinoid reduction can occur spontaneously; no separate reductase or specific physiological electron donor is assigned.	"[{""reference_id"": ""RHEA:57692"", ""source_assertion"": ""RHEA:57693 products contain GENERIC:16964 with coefficient 2; the compound is cob(I)inamide-[corrinoid adenosyltransferase]."", ""source_locator"": ""http://rdf.rhea-db.org/57693 rh:products; http://rdf.rhea-db.org/57692_R rh:contains2 http://rdf.rhea-db.org/Participant_57692_compound_16964; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:57692"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57692 and left-to-right 57693"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-007_c9d8340528d0	RHEA:57693	pathwaymech:produces	RHEA-COMP:10685	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57692	Coefficient 1 in the selected Rhea direction. This is a whole generic protein state, not its isolated reactive part or an identified E. coli sequence. The bound-corrinoid reduction can occur spontaneously; no separate reductase or specific physiological electron donor is assigned.	"[{""reference_id"": ""RHEA:57692"", ""source_assertion"": ""RHEA:57693 products contain GENERIC:10685 with coefficient 1; the compound is oxidized [electron-transfer flavoprotein]."", ""source_locator"": ""http://rdf.rhea-db.org/57693 rh:products; http://rdf.rhea-db.org/57692_R rh:contains1 http://rdf.rhea-db.org/Participant_57692_compound_10685; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:57692"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57692 and left-to-right 57693"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-008_95677c89a915	RHEA:57693	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-19338|RHEA:57692	Coefficient 3 in the selected Rhea direction. The bound-corrinoid reduction can occur spontaneously; no separate reductase or specific physiological electron donor is assigned.	"[{""reference_id"": ""RHEA:57692"", ""source_assertion"": ""RHEA:57693 products contain CHEBI:15378 with coefficient 3; the compound is H(+)."", ""source_locator"": ""http://rdf.rhea-db.org/57693 rh:products; http://rdf.rhea-db.org/57692_R rh:contains3 http://rdf.rhea-db.org/Participant_57692_compound_3249; rh:compound/rh:accession""}, {""reference_id"": ""MetaCyc:RXN-19338"", ""source_assertion"": ""RXN-19338 is spontaneous and produces 2 PROTON, whereas the selected Rhea142 reaction produces 3 H(+). The graph consistently uses the Rhea charge convention, not the old native proton coefficient."", ""source_locator"": ""Reaction[@frameid='RXN-19338']/spontaneous; right[Compound/@frameid='PROTON']/coefficient""}]"	"[{""id"": ""MetaCyc:RXN-19338"", ""source_sha256"": ""320798c30b897b1153aa305818cf1aa6532f74a3f5c036862f26ab3913aca5bb"", ""source_version"": ""Public MetaCyc Pathway Tools 22.5 XML; retrieved 2026-10-10; exact response-body digest"", ""title"": ""MetaCyc native spontaneous bound-corrinoid reduction"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19338""}, {""id"": ""RHEA:57692"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57692 and left-to-right 57693"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-009_578e0e69be75	RHEA-COMP:16964	pathwaymech:consumes	RHEA:57697	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57696	Coefficient 1 in the selected Rhea direction. This is a whole generic protein state, not its isolated reactive part or an identified E. coli sequence.	"[{""reference_id"": ""RHEA:57696"", ""source_assertion"": ""RHEA:57697 substrates contain GENERIC:16964 with coefficient 1; the compound is cob(I)inamide-[corrinoid adenosyltransferase]."", ""source_locator"": ""http://rdf.rhea-db.org/57697 rh:substrates; http://rdf.rhea-db.org/57696_L rh:contains1 http://rdf.rhea-db.org/Participant_57696_compound_16964; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:57696"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57696 and left-to-right 57697"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-010_2c76460ba59e	CHEBI:30616	pathwaymech:consumes	RHEA:57697	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57696	Coefficient 1 in the selected Rhea direction.	"[{""reference_id"": ""RHEA:57696"", ""source_assertion"": ""RHEA:57697 substrates contain CHEBI:30616 with coefficient 1; the compound is ATP."", ""source_locator"": ""http://rdf.rhea-db.org/57697 rh:substrates; http://rdf.rhea-db.org/57696_L rh:contains1 http://rdf.rhea-db.org/Participant_57696_compound_6372; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:57696"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57696 and left-to-right 57697"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-011_84010982e057	RHEA:57697	pathwaymech:produces	RHEA-COMP:14743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57696	Coefficient 1 in the selected Rhea direction. This is a whole generic protein state, not its isolated reactive part or an identified E. coli sequence.	"[{""reference_id"": ""RHEA:57696"", ""source_assertion"": ""RHEA:57697 products contain GENERIC:14743 with coefficient 1; the compound is apo-[corrinoid adenosyltransferase]."", ""source_locator"": ""http://rdf.rhea-db.org/57697 rh:products; http://rdf.rhea-db.org/57696_R rh:contains1 http://rdf.rhea-db.org/Participant_57696_compound_14743; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:57696"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57696 and left-to-right 57697"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-012_6002b99dd345	RHEA:57697	pathwaymech:produces	CHEBI:2480	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57696	Coefficient 1 in the selected Rhea direction.	"[{""reference_id"": ""RHEA:57696"", ""source_assertion"": ""RHEA:57697 products contain CHEBI:2480 with coefficient 1; the compound is adenosylcob(III)inamide."", ""source_locator"": ""http://rdf.rhea-db.org/57697 rh:products; http://rdf.rhea-db.org/57696_R rh:contains1 http://rdf.rhea-db.org/Participant_57696_compound_4575; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:57696"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57696 and left-to-right 57697"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-013_34505cfbdfe1	RHEA:57697	pathwaymech:produces	CHEBI:18036	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57696	Coefficient 1 in the selected Rhea direction.	"[{""reference_id"": ""RHEA:57696"", ""source_assertion"": ""RHEA:57697 products contain CHEBI:18036 with coefficient 1; the compound is triphosphate."", ""source_locator"": ""http://rdf.rhea-db.org/57697 rh:products; http://rdf.rhea-db.org/57696_R rh:contains1 http://rdf.rhea-db.org/Participant_57696_compound_5288; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:57696"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57696 and left-to-right 57697"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-014_6f25b4d7dfdc	CHEBI:2480	pathwaymech:consumes	RHEA:15770	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15769	Coefficient 1 in the selected Rhea direction.	"[{""reference_id"": ""RHEA:15769"", ""source_assertion"": ""RHEA:15770 substrates contain CHEBI:2480 with coefficient 1; the compound is adenosylcob(III)inamide."", ""source_locator"": ""http://rdf.rhea-db.org/15770 rh:substrates; http://rdf.rhea-db.org/15769_L rh:contains1 http://rdf.rhea-db.org/Participant_15769_compound_4575; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15769"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 15769 and left-to-right 15770"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-015_74cec5282954	CHEBI:30616	pathwaymech:consumes	RHEA:15770	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15769	Coefficient 1 in the selected Rhea direction.	"[{""reference_id"": ""RHEA:15769"", ""source_assertion"": ""RHEA:15770 substrates contain CHEBI:30616 with coefficient 1; the compound is ATP."", ""source_locator"": ""http://rdf.rhea-db.org/15770 rh:substrates; http://rdf.rhea-db.org/15769_L rh:contains1 http://rdf.rhea-db.org/Participant_15769_compound_6372; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15769"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 15769 and left-to-right 15770"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-016_6e55a72424fc	RHEA:15770	pathwaymech:produces	CHEBI:58502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15769	Coefficient 1 in the selected Rhea direction.	"[{""reference_id"": ""RHEA:15769"", ""source_assertion"": ""RHEA:15770 products contain CHEBI:58502 with coefficient 1; the compound is adenosylcob(III)inamide phosphate."", ""source_locator"": ""http://rdf.rhea-db.org/15770 rh:products; http://rdf.rhea-db.org/15769_R rh:contains1 http://rdf.rhea-db.org/Participant_15769_compound_3151; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15769"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 15769 and left-to-right 15770"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-017_2450d1419683	RHEA:15770	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15769	Coefficient 1 in the selected Rhea direction.	"[{""reference_id"": ""RHEA:15769"", ""source_assertion"": ""RHEA:15770 products contain CHEBI:456216 with coefficient 1; the compound is ADP."", ""source_locator"": ""http://rdf.rhea-db.org/15770 rh:products; http://rdf.rhea-db.org/15769_R rh:contains1 http://rdf.rhea-db.org/Participant_15769_compound_2710; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15769"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 15769 and left-to-right 15770"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-018_c7aab4799b37	RHEA:15770	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15769	Coefficient 1 in the selected Rhea direction.	"[{""reference_id"": ""RHEA:15769"", ""source_assertion"": ""RHEA:15770 products contain CHEBI:15378 with coefficient 1; the compound is H(+)."", ""source_locator"": ""http://rdf.rhea-db.org/15770 rh:products; http://rdf.rhea-db.org/15769_R rh:contains1 http://rdf.rhea-db.org/Participant_15769_compound_3249; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15769"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 15769 and left-to-right 15770"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-019_6e87e54d9252	CHEBI:58502	pathwaymech:consumes	RHEA:22713	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22712	Coefficient 1 in the selected Rhea direction.	"[{""reference_id"": ""RHEA:22712"", ""source_assertion"": ""RHEA:22713 substrates contain CHEBI:58502 with coefficient 1; the compound is adenosylcob(III)inamide phosphate."", ""source_locator"": ""http://rdf.rhea-db.org/22713 rh:substrates; http://rdf.rhea-db.org/22712_L rh:contains1 http://rdf.rhea-db.org/Participant_22712_compound_3151; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22712"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 22712 and left-to-right 22713"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-020_0407e7a15459	CHEBI:37565	pathwaymech:consumes	RHEA:22713	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22712	Coefficient 1 in the selected Rhea direction.	"[{""reference_id"": ""RHEA:22712"", ""source_assertion"": ""RHEA:22713 substrates contain CHEBI:37565 with coefficient 1; the compound is GTP."", ""source_locator"": ""http://rdf.rhea-db.org/22713 rh:substrates; http://rdf.rhea-db.org/22712_L rh:contains1 http://rdf.rhea-db.org/Participant_22712_compound_6355; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22712"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 22712 and left-to-right 22713"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-021_7f824f4cb16f	CHEBI:15378	pathwaymech:consumes	RHEA:22713	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22712	Coefficient 1 in the selected Rhea direction.	"[{""reference_id"": ""RHEA:22712"", ""source_assertion"": ""RHEA:22713 substrates contain CHEBI:15378 with coefficient 1; the compound is H(+)."", ""source_locator"": ""http://rdf.rhea-db.org/22713 rh:substrates; http://rdf.rhea-db.org/22712_L rh:contains1 http://rdf.rhea-db.org/Participant_22712_compound_3249; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22712"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 22712 and left-to-right 22713"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-022_632328cf4d05	RHEA:22713	pathwaymech:produces	CHEBI:60487	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22712	Coefficient 1 in the selected Rhea direction.	"[{""reference_id"": ""RHEA:22712"", ""source_assertion"": ""RHEA:22713 products contain CHEBI:60487 with coefficient 1; the compound is adenosylcob(III)inamide-GDP."", ""source_locator"": ""http://rdf.rhea-db.org/22713 rh:products; http://rdf.rhea-db.org/22712_R rh:contains1 http://rdf.rhea-db.org/Participant_22712_compound_6530; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22712"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 22712 and left-to-right 22713"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-023_ee31bc23d443	RHEA:22713	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22712	Coefficient 1 in the selected Rhea direction.	"[{""reference_id"": ""RHEA:22712"", ""source_assertion"": ""RHEA:22713 products contain CHEBI:33019 with coefficient 1; the compound is diphosphate."", ""source_locator"": ""http://rdf.rhea-db.org/22713 rh:products; http://rdf.rhea-db.org/22712_R rh:contains1 http://rdf.rhea-db.org/Participant_22712_compound_2106; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22712"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 22712 and left-to-right 22713"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-024_59fc5ddcf11f	UniProtKB:P0A9H5	pathwaymech:enables	RHEA:57697	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BTUR2-RXN|PMID:7592411|RHEA:57696|UniProtKB:P0A9H5	BtuR has the annotated cobinamide adenosyltransferase role. Assignment to the adenosyl-transfer component follows the native composite decomposition and matching Rhea chemistry; it is not a purified E. coli component assay or a claim that a monomer is sufficient. K-12 genetics supports this role, with anaerobic bypass; the feeding experiment did not isolate the charged component reaction.	"[{""reference_id"": ""UniProtKB:P0A9H5"", ""source_assertion"": ""The ECOLI protein unifies with P0A9H5 and catalyzes BTUR2-RXN through BTUR2-ENZRXN. Its comment bases the cobinamide assignment on sequence similarity and heterologous complementation."", ""source_locator"": ""Protein[@frameid='COBALADENOSYLTRANS-MONOMER']/dblink[dblink-db='UNIPROT']; catalyzes/Enzymatic-Reaction[@frameid='BTUR2-ENZRXN']; comment""}, {""reference_id"": ""MetaCyc:BTUR2-RXN"", ""source_assertion"": ""The cobinamide adenosyltransferase composite contains RXN-19342, RXN-19338 and RXN-19343 and unifies with RHEA:14726. The selected component RXN-19343 performs adenosyl transfer."", ""source_locator"": ""Reaction[@frameid='BTUR2-RXN']/reaction-list; dblink[dblink-db='RHEA']""}, {""reference_id"": ""RHEA:57696"", ""source_assertion"": ""RHEA:57697 explicitly cross-references MetaCyc RXN-19343 and converts bound cob(I)inamide plus ATP to apo-enzyme, adenosylcob(III)inamide and triphosphate."", ""source_locator"": ""http://rdf.rhea-db.org/57697 rdfs:seeAlso; rh:substrates; rh:products""}, {""reference_id"": ""UniProtKB:P0A9H5"", ""source_assertion"": ""The native BTUR2-ENZRXN assignment explicitly carries EV-COMP-HINF-FN-FROM-SEQ evidence citing PMID:7916712. This is inferred function, not a direct E. coli enzyme assay."", ""source_locator"": ""https://pathway.yeastgenome.org/getxml?ECOLI:BTUR2-ENZRXN; Enzymatic-Reaction/evidence; enzyme; reaction""}, {""reference_id"": ""PMID:7592411"", ""source_assertion"": ""K-12 W3110 DNA supplied cob genes by complementation. Tables 2 and 3 and the btuR results distinguish aerobic cobinamide dependence from anaerobic utilization by btuR mutants."", ""source_locator"": ""Full primary PDF pp. 6373, 6375-6376; Cloning the E. coli cob genes by complementation; Tables 2/3; btuR results""}, {""quote"": ""mutants can also convert cobinamide to cobalamin under anaerobic conditions"", ""reference_id"": ""PMID:7592411"", ""source_locator"": ""Full primary PDF p.6376, btuR results paragraph""}]"	"[{""id"": ""MetaCyc:BTUR2-RXN"", ""source_sha256"": ""3db47398898c1d3ceec242c01aec3954cd517f646020867a11203543f939a6ab"", ""source_version"": ""Public MetaCyc Pathway Tools 22.5 XML; retrieved 2026-10-10; exact response-body digest"", ""title"": ""MetaCyc BTUR2-RXN native activation definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BTUR2-RXN""}, {""id"": ""PMID:7592411"", ""source_sha256"": ""42da7e9bae0a77458a857218fe302469602a6e9247cb4e5092af60c362ad122b"", ""source_version"": ""Full primary1995 paper; retrieved2026-10-10; DOI10.1128/jb.177.22.6371-6380.1995; exact PDF response digest"", ""title"": ""The cobalamin (coenzyme B12) biosynthetic genes of Escherichia coli."", ""url"": ""https://europepmc.org/articles/PMC177486?pdf=render""}, {""id"": ""RHEA:57696"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57696 and left-to-right 57697"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0A9H5"", ""source_sha256"": ""296e93600bf8b0048338549b913f082206479791afbffeea0c1bd037d8832f81"", ""source_version"": ""Public EcoCyc Pathway Tools22.5 XML, explicit UniProt P0A9H5 crosswalk; retrieved2026-10-10; exact XML response digest"", ""title"": ""EcoCyc native P0A9H5/BtuR protein and cobinamide assignment"", ""url"": ""https://pathway.yeastgenome.org/getxml?ECOLI:COBALADENOSYLTRANS-MONOMER""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-025_e2cb03ce5297	PathBank:SMP0001898/ProteinComplex/3868	pathwaymech:catalyzes	RHEA:15770	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0001898|RHEA:15769|UniProtKB:P0AE76	This source-defined CobU homodimer projection carries the indicated activity. Its two P0AE76 subunits and reaction control are explicit in PathBank; reviewed catalytic assignment is by similarity to Q05599. The two native projections are not asserted to be different enzyme species or joined by a sameAs assertion.	"[{""reference_id"": ""PathBank:SMP0001898"", ""source_assertion"": ""ReactionCatalysis/5113 assigns ProteinComplex/3868 as controller of Reactions/5140; its left-to-right chemical equation is the ATP-dependent kinase conversion."", ""source_locator"": ""PW001884.owl#ReactionCatalysis/5113/bp:controller; bp:controlled; #Reactions/5140/bp:left; bp:right; bp:name; bp:conversionDirection""}, {""reference_id"": ""UniProtKB:P0AE76"", ""source_assertion"": ""The reviewed catalytic-activity comment assigns RHEA:15769, with ECO:0000250 evidence from UniProtKB:Q05599; the SUBUNIT comment says homodimer by similarity."", ""source_locator"": ""comments[commentType=\""CATALYTIC ACTIVITY\""].reaction[reactionCrossReferences.id=\""RHEA:15769\""]; evidences; comments[commentType=\""SUBUNIT\""]""}, {""reference_id"": ""RHEA:15769"", ""source_assertion"": ""RHEA:15769 lists RHEA:15770 as a directional reaction; its substrates and products select the forward salvage direction."", ""source_locator"": ""http://rdf.rhea-db.org/15769 rh:directionalReaction; http://rdf.rhea-db.org/15770 rh:substrates; rh:products""}]"	"[{""id"": ""PathBank:SMP0001898"", ""source_sha256"": ""4b4233814e281b298cf718f03ae89c2c0af8e70a278ccd0ea0664d8575499612"", ""source_version"": ""Native PW001884.owl member; retrieved2026-10-10; digest covers exact uncompressed member bytes, not the ZIP; wider source pathway is not claimed covered"", ""title"": ""PathBank native adenosylcobalamin salvage diagram, CobU role and location projections"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:15769"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 15769 and left-to-right 15770"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0AE76"", ""source_sha256"": ""9dcafc5f8310cfda4d872c4ff1daf1bbfed994b7e5b4cceee9a661d208d5c45c"", ""source_version"": ""UniProt2026_03; retrieved2026-10-10; exact JSON response digest"", ""title"": ""Reviewed UniProt CobU catalytic and subunit annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AE76.json""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-026_aae83f56bb98	PathBank:SMP0001898/ProteinComplex/3869_Cytosol	pathwaymech:catalyzes	RHEA:22713	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0001898|RHEA:22712|UniProtKB:P0AE76	This source-defined CobU homodimer projection carries the indicated activity. Its two P0AE76 subunits and reaction control are explicit in PathBank; reviewed catalytic assignment is by similarity to Q05599. The two native projections are not asserted to be different enzyme species or joined by a sameAs assertion. Native Reactions/5141 has a copied kinase EC/display label; its chemical sides and current UniProt/Rhea identify guanylyl transfer instead.	"[{""reference_id"": ""PathBank:SMP0001898"", ""source_assertion"": ""ReactionCatalysis/5114 assigns ProteinComplex/3869_Cytosol as controller of Reactions/5141; its left-to-right chemical equation is the GTP-dependent guanylyltransferase conversion."", ""source_locator"": ""PW001884.owl#ReactionCatalysis/5114/bp:controller; bp:controlled; #Reactions/5141/bp:left; bp:right; bp:name; bp:conversionDirection""}, {""reference_id"": ""UniProtKB:P0AE76"", ""source_assertion"": ""The reviewed catalytic-activity comment assigns RHEA:22712, with ECO:0000250 evidence from UniProtKB:Q05599; the SUBUNIT comment says homodimer by similarity."", ""source_locator"": ""comments[commentType=\""CATALYTIC ACTIVITY\""].reaction[reactionCrossReferences.id=\""RHEA:22712\""]; evidences; comments[commentType=\""SUBUNIT\""]""}, {""reference_id"": ""RHEA:22712"", ""source_assertion"": ""RHEA:22712 lists RHEA:22713 as a directional reaction; its substrates and products select the forward salvage direction."", ""source_locator"": ""http://rdf.rhea-db.org/22712 rh:directionalReaction; http://rdf.rhea-db.org/22713 rh:substrates; rh:products""}]"	"[{""id"": ""PathBank:SMP0001898"", ""source_sha256"": ""4b4233814e281b298cf718f03ae89c2c0af8e70a278ccd0ea0664d8575499612"", ""source_version"": ""Native PW001884.owl member; retrieved2026-10-10; digest covers exact uncompressed member bytes, not the ZIP; wider source pathway is not claimed covered"", ""title"": ""PathBank native adenosylcobalamin salvage diagram, CobU role and location projections"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:22712"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 22712 and left-to-right 22713"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0AE76"", ""source_sha256"": ""9dcafc5f8310cfda4d872c4ff1daf1bbfed994b7e5b4cceee9a661d208d5c45c"", ""source_version"": ""UniProt2026_03; retrieved2026-10-10; exact JSON response digest"", ""title"": ""Reviewed UniProt CobU catalytic and subunit annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AE76.json""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-027_37e6c17c8a65	RHEA:57689	BFO:0000050	MetaCyc:PWY-7971	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7971|RHEA:57688	This is one of the five reactions of the native activation subpathway. Native and Rhea component identities are reconciled without adding the composite net reaction. K-12 scope combines native MG1655 annotation with W3110-derived genetics, not a claim of primary testing in every substrain.	"[{""reference_id"": ""MetaCyc:PWY-7971"", ""source_assertion"": ""PWY-7971 explicitly lists RXN-19342 and selects its left-to-right direction."", ""source_locator"": ""Pathway[@frameid=\""PWY-7971\""]/reaction-list; reaction-layout[Reaction/@frameid=\""RXN-19342\""]""}, {""reference_id"": ""RHEA:57688"", ""source_assertion"": ""RHEA:57689 cross-references MetaCyc RXN-19342; its master RHEA:57688 lists this directional reaction."", ""source_locator"": ""http://rdf.rhea-db.org/57689 rdfs:seeAlso http://identifiers.org/biocyc/METACYC:RXN-19342; http://rdf.rhea-db.org/57688 rh:directionalReaction""}, {""reference_id"": ""MetaCyc:PWY-7971"", ""source_assertion"": ""PWY-7971 includes Escherichia coli K-12 MG1655 and experimental mutant-phenotype evidence citing PMID:7592411; this source also contains a Salmonella scope not represented here."", ""source_locator"": ""Pathway[@frameid='PWY-7971']/species; evidence""}]"	"[{""id"": ""MetaCyc:PWY-7971"", ""source_sha256"": ""28327053c1613e7787c7e0b7cc76af03e31730c3cf12bea215fe8d8a7bebc2cb"", ""source_version"": ""Public MetaCyc Pathway Tools 22.5 XML; retrieved 2026-10-10; exact response-body digest"", ""title"": ""MetaCyc PWY-7971 native activation definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7971""}, {""id"": ""RHEA:57688"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57688 and left-to-right 57689"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-028_ce0d8965411b	RHEA:57693	BFO:0000050	MetaCyc:PWY-7971	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7971|MetaCyc:RXN-19338|RHEA:57692	This is one of the five reactions of the native activation subpathway. Native and Rhea component identities are reconciled without adding the composite net reaction.	"[{""reference_id"": ""MetaCyc:PWY-7971"", ""source_assertion"": ""PWY-7971 explicitly lists RXN-19338 and selects its left-to-right direction."", ""source_locator"": ""Pathway[@frameid=\""PWY-7971\""]/reaction-list; reaction-layout[Reaction/@frameid=\""RXN-19338\""]""}, {""reference_id"": ""MetaCyc:RXN-19338"", ""source_assertion"": ""RXN-19338 reduces two bound cob(II)inamide states (CPD-20906) to bound cob(I)inamide (CPD-20907), with reduced/oxidized flavoproteins. This is the selected chemical correspondence, with the proton coefficient difference retained."", ""source_locator"": ""Reaction[@frameid='RXN-19338']/left; right; spontaneous""}, {""reference_id"": ""RHEA:57692"", ""source_assertion"": ""RHEA:57692 lists directional RHEA:57693 and the same bound-corrinoid reduction with whole reduced/oxidized flavoproteins; Rhea uses coefficient 3 for H(+). No native cross-reference is claimed for this component."", ""source_locator"": ""http://rdf.rhea-db.org/57692 rh:directionalReaction; rh:equation; http://rdf.rhea-db.org/57692_R rh:contains3""}]"	"[{""id"": ""MetaCyc:PWY-7971"", ""source_sha256"": ""28327053c1613e7787c7e0b7cc76af03e31730c3cf12bea215fe8d8a7bebc2cb"", ""source_version"": ""Public MetaCyc Pathway Tools 22.5 XML; retrieved 2026-10-10; exact response-body digest"", ""title"": ""MetaCyc PWY-7971 native activation definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7971""}, {""id"": ""MetaCyc:RXN-19338"", ""source_sha256"": ""320798c30b897b1153aa305818cf1aa6532f74a3f5c036862f26ab3913aca5bb"", ""source_version"": ""Public MetaCyc Pathway Tools 22.5 XML; retrieved 2026-10-10; exact response-body digest"", ""title"": ""MetaCyc native spontaneous bound-corrinoid reduction"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19338""}, {""id"": ""RHEA:57692"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57692 and left-to-right 57693"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-029_0177149284da	RHEA:57697	BFO:0000050	MetaCyc:PWY-7971	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7971|RHEA:57696	This is one of the five reactions of the native activation subpathway. Native and Rhea component identities are reconciled without adding the composite net reaction.	"[{""reference_id"": ""MetaCyc:PWY-7971"", ""source_assertion"": ""PWY-7971 explicitly lists RXN-19343 and selects its left-to-right direction."", ""source_locator"": ""Pathway[@frameid=\""PWY-7971\""]/reaction-list; reaction-layout[Reaction/@frameid=\""RXN-19343\""]""}, {""reference_id"": ""RHEA:57696"", ""source_assertion"": ""RHEA:57697 cross-references MetaCyc RXN-19343; its master RHEA:57696 lists this directional reaction."", ""source_locator"": ""http://rdf.rhea-db.org/57697 rdfs:seeAlso http://identifiers.org/biocyc/METACYC:RXN-19343; http://rdf.rhea-db.org/57696 rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:PWY-7971"", ""source_sha256"": ""28327053c1613e7787c7e0b7cc76af03e31730c3cf12bea215fe8d8a7bebc2cb"", ""source_version"": ""Public MetaCyc Pathway Tools 22.5 XML; retrieved 2026-10-10; exact response-body digest"", ""title"": ""MetaCyc PWY-7971 native activation definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7971""}, {""id"": ""RHEA:57696"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57696 and left-to-right 57697"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-030_b2795f5bd830	RHEA:15770	BFO:0000050	MetaCyc:PWY-7971	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7971|RHEA:15769	This is one of the five reactions of the native activation subpathway. Native and Rhea component identities are reconciled without adding the composite net reaction.	"[{""reference_id"": ""MetaCyc:PWY-7971"", ""source_assertion"": ""PWY-7971 explicitly lists COBINAMIDEKIN-RXN and selects its left-to-right direction."", ""source_locator"": ""Pathway[@frameid=\""PWY-7971\""]/reaction-list; reaction-layout[Reaction/@frameid=\""COBINAMIDEKIN-RXN\""]""}, {""reference_id"": ""RHEA:15769"", ""source_assertion"": ""RHEA:15770 cross-references MetaCyc COBINAMIDEKIN-RXN; its master RHEA:15769 lists this directional reaction."", ""source_locator"": ""http://rdf.rhea-db.org/15770 rdfs:seeAlso http://identifiers.org/biocyc/METACYC:COBINAMIDEKIN-RXN; http://rdf.rhea-db.org/15769 rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:PWY-7971"", ""source_sha256"": ""28327053c1613e7787c7e0b7cc76af03e31730c3cf12bea215fe8d8a7bebc2cb"", ""source_version"": ""Public MetaCyc Pathway Tools 22.5 XML; retrieved 2026-10-10; exact response-body digest"", ""title"": ""MetaCyc PWY-7971 native activation definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7971""}, {""id"": ""RHEA:15769"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 15769 and left-to-right 15770"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-031_a2fac5c9d079	RHEA:22713	BFO:0000050	MetaCyc:PWY-7971	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7971|RHEA:22712	This is one of the five reactions of the native activation subpathway. Native and Rhea component identities are reconciled without adding the composite net reaction.	"[{""reference_id"": ""MetaCyc:PWY-7971"", ""source_assertion"": ""PWY-7971 explicitly lists COBINPGUANYLYLTRANS-RXN and selects its left-to-right direction."", ""source_locator"": ""Pathway[@frameid=\""PWY-7971\""]/reaction-list; reaction-layout[Reaction/@frameid=\""COBINPGUANYLYLTRANS-RXN\""]""}, {""reference_id"": ""RHEA:22712"", ""source_assertion"": ""RHEA:22713 cross-references MetaCyc COBINPGUANYLYLTRANS-RXN; its master RHEA:22712 lists this directional reaction."", ""source_locator"": ""http://rdf.rhea-db.org/22713 rdfs:seeAlso http://identifiers.org/biocyc/METACYC:COBINPGUANYLYLTRANS-RXN; http://rdf.rhea-db.org/22712 rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:PWY-7971"", ""source_sha256"": ""28327053c1613e7787c7e0b7cc76af03e31730c3cf12bea215fe8d8a7bebc2cb"", ""source_version"": ""Public MetaCyc Pathway Tools 22.5 XML; retrieved 2026-10-10; exact response-body digest"", ""title"": ""MetaCyc PWY-7971 native activation definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7971""}, {""id"": ""RHEA:22712"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 22712 and left-to-right 22713"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-032_e2ad14e8a95c	RHEA:57689	RO:0002413	RHEA:57693	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57688|RHEA:57692	The reactions share this exact chemical or whole bound-protein state. Different equation scaling is retained; this edge does not assert physical channeling or a protein complex.	"[{""reference_id"": ""RHEA:57688"", ""source_assertion"": ""RHEA:57689 produces RHEA-COMP:14966 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/57689 rh:products; http://rdf.rhea-db.org/57688_R rh:contains1 http://rdf.rhea-db.org/Participant_57688_compound_14966; rh:compound/rh:accession""}, {""reference_id"": ""RHEA:57692"", ""source_assertion"": ""RHEA:57693 consumes RHEA-COMP:14966 with coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/57693 rh:substrates; http://rdf.rhea-db.org/57692_L rh:contains2 http://rdf.rhea-db.org/Participant_57692_compound_14966; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:57688"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57688 and left-to-right 57689"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:57692"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57692 and left-to-right 57693"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-033_6f47e10cdef3	RHEA:57693	RO:0002413	RHEA:57697	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:57692|RHEA:57696	The reactions share this exact chemical or whole bound-protein state. Different equation scaling is retained; this edge does not assert physical channeling or a protein complex.	"[{""reference_id"": ""RHEA:57692"", ""source_assertion"": ""RHEA:57693 produces RHEA-COMP:16964 with coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/57693 rh:products; http://rdf.rhea-db.org/57692_R rh:contains2 http://rdf.rhea-db.org/Participant_57692_compound_16964; rh:compound/rh:accession""}, {""reference_id"": ""RHEA:57696"", ""source_assertion"": ""RHEA:57697 consumes RHEA-COMP:16964 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/57697 rh:substrates; http://rdf.rhea-db.org/57696_L rh:contains1 http://rdf.rhea-db.org/Participant_57696_compound_16964; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:57692"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57692 and left-to-right 57693"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:57696"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57696 and left-to-right 57697"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-034_bd8308e9cf4c	RHEA:57697	RO:0002413	RHEA:15770	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15769|RHEA:57696	The reactions share this exact chemical or whole bound-protein state. Different equation scaling is retained; this edge does not assert physical channeling or a protein complex.	"[{""reference_id"": ""RHEA:57696"", ""source_assertion"": ""RHEA:57697 produces CHEBI:2480 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/57697 rh:products; http://rdf.rhea-db.org/57696_R rh:contains1 http://rdf.rhea-db.org/Participant_57696_compound_4575; rh:compound/rh:accession""}, {""reference_id"": ""RHEA:15769"", ""source_assertion"": ""RHEA:15770 consumes CHEBI:2480 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/15770 rh:substrates; http://rdf.rhea-db.org/15769_L rh:contains1 http://rdf.rhea-db.org/Participant_15769_compound_4575; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15769"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 15769 and left-to-right 15770"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:57696"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 57696 and left-to-right 57697"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-035_3a728a1ee918	RHEA:15770	RO:0002413	RHEA:22713	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15769|RHEA:22712	The reactions share this exact chemical or whole bound-protein state. Different equation scaling is retained; this edge does not assert physical channeling or a protein complex.	"[{""reference_id"": ""RHEA:15769"", ""source_assertion"": ""RHEA:15770 produces CHEBI:58502 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/15770 rh:products; http://rdf.rhea-db.org/15769_R rh:contains1 http://rdf.rhea-db.org/Participant_15769_compound_3151; rh:compound/rh:accession""}, {""reference_id"": ""RHEA:22712"", ""source_assertion"": ""RHEA:22713 consumes CHEBI:58502 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22713 rh:substrates; http://rdf.rhea-db.org/22712_L rh:contains1 http://rdf.rhea-db.org/Participant_22712_compound_3151; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15769"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 15769 and left-to-right 15770"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:22712"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""Rhea 22712 and left-to-right 22713"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-036_ef5456f07b13	UniProtKB:P0AE76	BFO:0000050	PathBank:SMP0001898/ProteinComplex/3868	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0001898|UniProtKB:P0AE76	The source declares coefficient 2 of CobU in this role/location projection. UniProt calls CobU a homodimer by similarity; native membership is not an independent structural determination.	"[{""reference_id"": ""PathBank:SMP0001898"", ""source_assertion"": ""ProteinComplex/3868 contains Protein/6232 with stoichiometricCoefficient 2.0; its ProteinReference/6232 has the UniProt P0AE76 unification cross-reference."", ""source_locator"": ""PW001884.owl#ProteinComplex/3868/bp:component; bp:componentStoichiometry; #Protein/6232/Stoichiometry/2.0; #ProteinReference/6232/bp:xref; #Reference/UniProt_P0AE76""}, {""reference_id"": ""UniProtKB:P0AE76"", ""source_assertion"": ""The SUBUNIT comment states Homodimer with ECO:0000250 evidence (by similarity)."", ""source_locator"": ""comments[commentType=\""SUBUNIT\""].texts""}]"	"[{""id"": ""PathBank:SMP0001898"", ""source_sha256"": ""4b4233814e281b298cf718f03ae89c2c0af8e70a278ccd0ea0664d8575499612"", ""source_version"": ""Native PW001884.owl member; retrieved2026-10-10; digest covers exact uncompressed member bytes, not the ZIP; wider source pathway is not claimed covered"", ""title"": ""PathBank native adenosylcobalamin salvage diagram, CobU role and location projections"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P0AE76"", ""source_sha256"": ""9dcafc5f8310cfda4d872c4ff1daf1bbfed994b7e5b4cceee9a661d208d5c45c"", ""source_version"": ""UniProt2026_03; retrieved2026-10-10; exact JSON response digest"", ""title"": ""Reviewed UniProt CobU catalytic and subunit annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AE76.json""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-037_ede2f6f96ed5	UniProtKB:P0AE76	BFO:0000050	PathBank:SMP0001898/ProteinComplex/3869_Cytosol	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0001898|UniProtKB:P0AE76	The source declares coefficient 2 of CobU in this role/location projection. UniProt calls CobU a homodimer by similarity; native membership is not an independent structural determination.	"[{""reference_id"": ""PathBank:SMP0001898"", ""source_assertion"": ""ProteinComplex/3869_Cytosol contains Protein/6232_Cytosol with stoichiometricCoefficient 2.0; its ProteinReference/6232 has the UniProt P0AE76 unification cross-reference."", ""source_locator"": ""PW001884.owl#ProteinComplex/3869_Cytosol/bp:component; bp:componentStoichiometry; #Protein/6232_Cytosol/Stoichiometry/2.0; #ProteinReference/6232/bp:xref; #Reference/UniProt_P0AE76""}, {""reference_id"": ""UniProtKB:P0AE76"", ""source_assertion"": ""The SUBUNIT comment states Homodimer with ECO:0000250 evidence (by similarity)."", ""source_locator"": ""comments[commentType=\""SUBUNIT\""].texts""}]"	"[{""id"": ""PathBank:SMP0001898"", ""source_sha256"": ""4b4233814e281b298cf718f03ae89c2c0af8e70a278ccd0ea0664d8575499612"", ""source_version"": ""Native PW001884.owl member; retrieved2026-10-10; digest covers exact uncompressed member bytes, not the ZIP; wider source pathway is not claimed covered"", ""title"": ""PathBank native adenosylcobalamin salvage diagram, CobU role and location projections"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P0AE76"", ""source_sha256"": ""9dcafc5f8310cfda4d872c4ff1daf1bbfed994b7e5b4cceee9a661d208d5c45c"", ""source_version"": ""UniProt2026_03; retrieved2026-10-10; exact JSON response digest"", ""title"": ""Reviewed UniProt CobU catalytic and subunit annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AE76.json""}]"	""
pathwaymech:MetaCyc_PWY-7971_activation-edge-038_173f037a5d08	PathBank:SMP0001898/ProteinComplex/3869_Cytosol	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0001898	Only the explicitly localized native CobU projection receives the cytosol edge; location is not automatically copied to the other projection.	"[{""reference_id"": ""PathBank:SMP0001898"", ""source_assertion"": ""ProteinComplex/3869_Cytosol has cellularLocation CellularLocation/Cytosol, whose unification xref is GO:0005829."", ""source_locator"": ""PW001884.owl#ProteinComplex/3869_Cytosol/bp:cellularLocation; #CellularLocation/Cytosol/bp:xref; #Reference/GENE_ONTOLOGY_GO_0005829""}]"	"[{""id"": ""PathBank:SMP0001898"", ""source_sha256"": ""4b4233814e281b298cf718f03ae89c2c0af8e70a278ccd0ea0664d8575499612"", ""source_version"": ""Native PW001884.owl member; retrieved2026-10-10; digest covers exact uncompressed member bytes, not the ZIP; wider source pathway is not claimed covered"", ""title"": ""PathBank native adenosylcobalamin salvage diagram, CobU role and location projections"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-001_12fb1f645ad5	CHEBI:57483	pathwaymech:consumes	RHEA:27490	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27490	This is the formal Rhea two-anomer equation, not a measured fixed in vivo product ratio.	"[{""reference_id"": ""RHEA:27490"", ""source_assertion"": ""RHEA:27490 assigns CHEBI:57483 to its substrates, coefficient 2 via rh:contains2."", ""source_locator"": ""http://rdf.rhea-db.org/27490 rh:substrates; http://rdf.rhea-db.org/27489_L rh:contains2 http://rdf.rhea-db.org/Participant_27489_compound_3830; http://rdf.rhea-db.org/Participant_27489_compound_3830 rh:compound http://rdf.rhea-db.org/Compound_3830; rh:chebi""}]"	"[{""id"": ""RHEA:27490"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27490"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-002_f1d5613013b2	RHEA:27490	pathwaymech:produces	CHEBI:60203	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27490	This is the formal Rhea two-anomer equation, not a measured fixed in vivo product ratio.	"[{""reference_id"": ""RHEA:27490"", ""source_assertion"": ""RHEA:27490 assigns CHEBI:60203 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/27490 rh:products; http://rdf.rhea-db.org/27489_R rh:contains1 http://rdf.rhea-db.org/Participant_27489_compound_6236; http://rdf.rhea-db.org/Participant_27489_compound_6236 rh:compound http://rdf.rhea-db.org/Compound_6236; rh:chebi""}]"	"[{""id"": ""RHEA:27490"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27490"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-003_98778e06027d	RHEA:27490	pathwaymech:produces	CHEBI:60204	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27490	This is the formal Rhea two-anomer equation, not a measured fixed in vivo product ratio.	"[{""reference_id"": ""RHEA:27490"", ""source_assertion"": ""RHEA:27490 assigns CHEBI:60204 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/27490 rh:products; http://rdf.rhea-db.org/27489_R rh:contains1 http://rdf.rhea-db.org/Participant_27489_compound_6311; http://rdf.rhea-db.org/Participant_27489_compound_6311 rh:compound http://rdf.rhea-db.org/Compound_6311; rh:chebi""}]"	"[{""id"": ""RHEA:27490"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27490"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-004_ed1465e6339f	CHEBI:60204	pathwaymech:consumes	RHEA:27474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27474		"[{""reference_id"": ""RHEA:27474"", ""source_assertion"": ""RHEA:27474 assigns CHEBI:60204 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/27474 rh:substrates; http://rdf.rhea-db.org/27473_L rh:contains1 http://rdf.rhea-db.org/Participant_27473_compound_6311; http://rdf.rhea-db.org/Participant_27473_compound_6311 rh:compound http://rdf.rhea-db.org/Compound_6311; rh:chebi""}]"	"[{""id"": ""RHEA:27474"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27474"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-005_8a3bc596e22a	CHEBI:30616	pathwaymech:consumes	RHEA:27474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27474		"[{""reference_id"": ""RHEA:27474"", ""source_assertion"": ""RHEA:27474 assigns CHEBI:30616 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/27474 rh:substrates; http://rdf.rhea-db.org/27473_L rh:contains1 http://rdf.rhea-db.org/Participant_27473_compound_6372; http://rdf.rhea-db.org/Participant_27473_compound_6372 rh:compound http://rdf.rhea-db.org/Compound_6372; rh:chebi""}]"	"[{""id"": ""RHEA:27474"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27474"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-006_b51f4536653a	RHEA:27474	pathwaymech:produces	CHEBI:60208	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27474		"[{""reference_id"": ""RHEA:27474"", ""source_assertion"": ""RHEA:27474 assigns CHEBI:60208 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/27474 rh:products; http://rdf.rhea-db.org/27473_R rh:contains1 http://rdf.rhea-db.org/Participant_27473_compound_6310; http://rdf.rhea-db.org/Participant_27473_compound_6310 rh:compound http://rdf.rhea-db.org/Compound_6310; rh:chebi""}]"	"[{""id"": ""RHEA:27474"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27474"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-007_b6f8e6a0e208	RHEA:27474	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27474		"[{""reference_id"": ""RHEA:27474"", ""source_assertion"": ""RHEA:27474 assigns CHEBI:456216 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/27474 rh:products; http://rdf.rhea-db.org/27473_R rh:contains1 http://rdf.rhea-db.org/Participant_27473_compound_2710; http://rdf.rhea-db.org/Participant_27473_compound_2710 rh:compound http://rdf.rhea-db.org/Compound_2710; rh:chebi""}]"	"[{""id"": ""RHEA:27474"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27474"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-008_b8ba5d7e6000	RHEA:27474	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27474		"[{""reference_id"": ""RHEA:27474"", ""source_assertion"": ""RHEA:27474 assigns CHEBI:15378 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/27474 rh:products; http://rdf.rhea-db.org/27473_R rh:contains1 http://rdf.rhea-db.org/Participant_27473_compound_3249; http://rdf.rhea-db.org/Participant_27473_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:27474"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27474"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-009_f318718fbba8	CHEBI:60208	pathwaymech:consumes	RHEA:28519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28519		"[{""reference_id"": ""RHEA:28519"", ""source_assertion"": ""RHEA:28519 assigns CHEBI:60208 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/28519 rh:substrates; http://rdf.rhea-db.org/28518_L rh:contains1 http://rdf.rhea-db.org/Participant_28518_compound_6310; http://rdf.rhea-db.org/Participant_28518_compound_6310 rh:compound http://rdf.rhea-db.org/Compound_6310; rh:chebi""}]"	"[{""id"": ""RHEA:28519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 28519"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-010_8f4b63cb031e	CHEBI:15377	pathwaymech:consumes	RHEA:28519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28519		"[{""reference_id"": ""RHEA:28519"", ""source_assertion"": ""RHEA:28519 assigns CHEBI:15377 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/28519 rh:substrates; http://rdf.rhea-db.org/28518_L rh:contains1 http://rdf.rhea-db.org/Participant_28518_compound_1283; http://rdf.rhea-db.org/Participant_28518_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; rh:chebi""}]"	"[{""id"": ""RHEA:28519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 28519"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-011_095cfd3f8ac3	RHEA:28519	pathwaymech:produces	CHEBI:61593	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28519		"[{""reference_id"": ""RHEA:28519"", ""source_assertion"": ""RHEA:28519 assigns CHEBI:61593 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/28519 rh:products; http://rdf.rhea-db.org/28518_R rh:contains1 http://rdf.rhea-db.org/Participant_28518_compound_6538; http://rdf.rhea-db.org/Participant_28518_compound_6538 rh:compound http://rdf.rhea-db.org/Compound_6538; rh:chebi""}]"	"[{""id"": ""RHEA:28519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 28519"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-012_6c71dccffcfa	RHEA:28519	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28519		"[{""reference_id"": ""RHEA:28519"", ""source_assertion"": ""RHEA:28519 assigns CHEBI:43474 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/28519 rh:products; http://rdf.rhea-db.org/28518_R rh:contains1 http://rdf.rhea-db.org/Participant_28518_compound_5518; http://rdf.rhea-db.org/Participant_28518_compound_5518 rh:compound http://rdf.rhea-db.org/Compound_5518; rh:chebi""}]"	"[{""id"": ""RHEA:28519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 28519"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-013_08630710ed78	CHEBI:61593	pathwaymech:consumes	RHEA:27466	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27466		"[{""reference_id"": ""RHEA:27466"", ""source_assertion"": ""RHEA:27466 assigns CHEBI:61593 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/27466 rh:substrates; http://rdf.rhea-db.org/27465_L rh:contains1 http://rdf.rhea-db.org/Participant_27465_compound_6538; http://rdf.rhea-db.org/Participant_27465_compound_6538 rh:compound http://rdf.rhea-db.org/Compound_6538; rh:chebi""}]"	"[{""id"": ""RHEA:27466"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27466"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-014_d7aa58bf603c	CHEBI:30616	pathwaymech:consumes	RHEA:27466	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27466		"[{""reference_id"": ""RHEA:27466"", ""source_assertion"": ""RHEA:27466 assigns CHEBI:30616 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/27466 rh:substrates; http://rdf.rhea-db.org/27465_L rh:contains1 http://rdf.rhea-db.org/Participant_27465_compound_6372; http://rdf.rhea-db.org/Participant_27465_compound_6372 rh:compound http://rdf.rhea-db.org/Compound_6372; rh:chebi""}]"	"[{""id"": ""RHEA:27466"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27466"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-015_08c3b063766f	CHEBI:15378	pathwaymech:consumes	RHEA:27466	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27466		"[{""reference_id"": ""RHEA:27466"", ""source_assertion"": ""RHEA:27466 assigns CHEBI:15378 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/27466 rh:substrates; http://rdf.rhea-db.org/27465_L rh:contains1 http://rdf.rhea-db.org/Participant_27465_compound_3249; http://rdf.rhea-db.org/Participant_27465_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:27466"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27466"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-016_83e942c424ba	RHEA:27466	pathwaymech:produces	CHEBI:59967	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27466		"[{""reference_id"": ""RHEA:27466"", ""source_assertion"": ""RHEA:27466 assigns CHEBI:59967 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/27466 rh:products; http://rdf.rhea-db.org/27465_R rh:contains1 http://rdf.rhea-db.org/Participant_27465_compound_6139; http://rdf.rhea-db.org/Participant_27465_compound_6139 rh:compound http://rdf.rhea-db.org/Compound_6139; rh:chebi""}]"	"[{""id"": ""RHEA:27466"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27466"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-017_e8418d079d2e	RHEA:27466	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27466		"[{""reference_id"": ""RHEA:27466"", ""source_assertion"": ""RHEA:27466 assigns CHEBI:33019 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/27466 rh:products; http://rdf.rhea-db.org/27465_R rh:contains1 http://rdf.rhea-db.org/Participant_27465_compound_2106; http://rdf.rhea-db.org/Participant_27465_compound_2106 rh:compound http://rdf.rhea-db.org/Compound_2106; rh:chebi""}]"	"[{""id"": ""RHEA:27466"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27466"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-018_9963ae2e12db	CHEBI:59967	pathwaymech:consumes	RHEA:17578	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17578		"[{""reference_id"": ""RHEA:17578"", ""source_assertion"": ""RHEA:17578 assigns CHEBI:59967 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/17578 rh:substrates; http://rdf.rhea-db.org/17577_L rh:contains1 http://rdf.rhea-db.org/Participant_17577_compound_6139; http://rdf.rhea-db.org/Participant_17577_compound_6139 rh:compound http://rdf.rhea-db.org/Compound_6139; rh:chebi""}]"	"[{""id"": ""RHEA:17578"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 17578"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-019_9a0d1b355247	RHEA:17578	pathwaymech:produces	CHEBI:61506	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17578		"[{""reference_id"": ""RHEA:17578"", ""source_assertion"": ""RHEA:17578 assigns CHEBI:61506 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/17578 rh:products; http://rdf.rhea-db.org/17577_R rh:contains1 http://rdf.rhea-db.org/Participant_17577_compound_6453; http://rdf.rhea-db.org/Participant_17577_compound_6453 rh:compound http://rdf.rhea-db.org/Compound_6453; rh:chebi""}]"	"[{""id"": ""RHEA:17578"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 17578"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-020_18b15655203e	MetaCyc:CPLX0-7660	pathwaymech:catalyzes	RHEA:27490	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7660|PMID:18056714|RHEA:27490|UniProtKB:P63224	The selected biosynthetic direction does not assert irreversible chemistry.	"[{""reference_id"": ""MetaCyc:CPLX0-7660"", ""source_assertion"": ""CPLX0-7660 has an explicit catalytic assignment to RXN0-4301."", ""source_locator"": ""Protein[@frameid=\""CPLX0-7660\""]/catalyzes/Enzymatic-Reaction/reaction/Reaction[@frameid=\""RXN0-4301\""]""}, {""reference_id"": ""UniProtKB:P63224"", ""source_assertion"": ""Reviewed K-12 P63224 CATALYTIC ACTIVITY gives RHEA:27489 and the corresponding equation with experimental ECO:0000269 evidence."", ""source_locator"": ""/organism/taxonId; /comments/1/reaction""}, {""reference_id"": ""RHEA:27490"", ""source_assertion"": ""Master RHEA:27489 explicitly links directionalReaction RHEA:27490, the left-to-right member in release 142."", ""source_locator"": ""http://rdf.rhea-db.org/27489 rh:directionalReaction http://rdf.rhea-db.org/27490; rhea-directions.tsv RHEA_ID_LR""}, {""reference_id"": ""PMID:18056714"", ""source_assertion"": ""The primary abstract reports E. coli and P. aeruginosa GmhA structures in apo, substrate and product forms, with mutant biochemistry and in vivo LPS analysis. It supports the E. coli isomerase assignment, without making the 2002 heterologous GmhA reagent an E. coli experiment."", ""source_locator"": ""/resultList/result[id=\""18056714\""]/abstractText""}]"	"[{""id"": ""MetaCyc:CPLX0-7660"", ""source_sha256"": ""654e02c7f2859815c92cef14f29298a8c30b038dedc86a97bf4bc0b27848d002"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""D-sedoheptulose 7-phosphate isomerase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7660""}, {""id"": ""PMID:18056714"", ""source_sha256"": ""8c810fb91735f8e1f9101f339d567c6d1b3da8931b880311819204ded7a37487"", ""source_version"": ""2008; Europe PMC indexed primary abstract; digest covers complete core XML response, not full article retrieved 2026-10-11 UTC"", ""title"": ""Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18056714%20AND%20SRC:MED&resultType=core&format=xml""}, {""id"": ""RHEA:27490"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27490"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P63224"", ""source_sha256"": ""33c3d881d53781ef0c0000d53918c2e4fd533fda609eff6c304028056ba2265a"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; complete reviewed JSON retrieved 2026-10-11 UTC"", ""title"": ""Phosphoheptose isomerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P63224.json""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-021_c791af8d0152	MetaCyc:CPLX0-3661	pathwaymech:catalyzes	RHEA:27474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-3661|PMID:11751812|RHEA:27474|UniProtKB:P76658		"[{""reference_id"": ""MetaCyc:CPLX0-3661"", ""source_assertion"": ""CPLX0-3661 has an explicit catalytic assignment to RXN0-4341."", ""source_locator"": ""Protein[@frameid=\""CPLX0-3661\""]/catalyzes/Enzymatic-Reaction/reaction/Reaction[@frameid=\""RXN0-4341\""]""}, {""reference_id"": ""UniProtKB:P76658"", ""source_assertion"": ""Reviewed K-12 P76658 CATALYTIC ACTIVITY gives RHEA:27473 and the corresponding equation with experimental ECO:0000269 evidence."", ""source_locator"": ""/organism/taxonId; /comments/2/reaction""}, {""reference_id"": ""RHEA:27474"", ""source_assertion"": ""Master RHEA:27473 explicitly links directionalReaction RHEA:27474, the left-to-right member in release 142."", ""source_locator"": ""http://rdf.rhea-db.org/27473 rh:directionalReaction http://rdf.rhea-db.org/27474; rhea-directions.tsv RHEA_ID_LR""}, {""reference_id"": ""PMID:11751812"", ""source_assertion"": ""Purified K-12 HldE and ATP generate beta-heptose 1,7-bisphosphate in coupled HPAEC experiments; the upstream GmhA reagent was from A. thermoaerophilus. The assay contained 10 mM MgCl2, which alone is not a separate HldE metal-binding measurement."", ""source_locator"": ""PMC139585 HTML (//article//p)[14,19,21]; Results/Biochemical characterization of the biosynthetic pathway; Figure 2""}]"	"[{""id"": ""MetaCyc:CPLX0-3661"", ""source_sha256"": ""ec6cb7464bf213dba096d84f7c93b28c33b6ec458463142c18848bb59bf9eaf1"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-3661""}, {""id"": ""PMID:11751812"", ""source_sha256"": ""fbcbc5a07e882efc3c230320e23ecd7a475b30fa4a4bc8d4707153138e850ef8"", ""source_version"": ""2002; complete primary article HTML/BioC response; exact response bytes retrieved 2026-10-11 UTC"", ""title"": ""Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC139585/""}, {""id"": ""RHEA:27474"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27474"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P76658"", ""source_sha256"": ""037ee3965f295c6fc72fcc7f6fbc2e8b01c4ec6037ba17b66d385f82166aec82"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; complete reviewed JSON retrieved 2026-10-11 UTC"", ""title"": ""Bifunctional protein HldE"", ""url"": ""https://rest.uniprot.org/uniprotkb/P76658.json""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-022_419f4e3acd42	UniProtKB:P63228	pathwaymech:catalyzes	RHEA:28519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:20050614|PMID:20050615|RHEA:28519|UniProtKB:P63228		"[{""reference_id"": ""UniProtKB:P63228"", ""source_assertion"": ""Reviewed K-12 P63228 CATALYTIC ACTIVITY gives RHEA:28518 and the corresponding equation with experimental ECO:0000269 evidence."", ""source_locator"": ""/organism/taxonId; /comments/1/reaction""}, {""reference_id"": ""RHEA:28519"", ""source_assertion"": ""Master RHEA:28518 explicitly links directionalReaction RHEA:28519, the left-to-right member in release 142."", ""source_locator"": ""http://rdf.rhea-db.org/28518 rh:directionalReaction http://rdf.rhea-db.org/28519; rhea-directions.tsv RHEA_ID_LR""}, {""reference_id"": ""PMID:20050615"", ""source_assertion"": ""E. coli K-12 GmhB selectively removes the C7 phosphate. Kinetics favor the beta over the alpha bisphosphate by about 100-fold; this is preference, not absolute alpha inactivity. The monophosphate product is not further hydrolyzed."", ""source_locator"": ""PMC2844805 HTML (//article//p)[43]; Results/Substrate specificity; Tables 1 and 2""}, {""reference_id"": ""PMID:20050614"", ""source_assertion"": ""Solution size-exclusion analysis supports monomeric E. coli GmhB; its substrate/Mg structure and catalytic-site analysis support C7 dephosphorylation. The paper prints an incorrect Swiss-Prot accession P63288; identity is independently grounded by native P63228 and current UniProt."", ""source_locator"": ""PMC2844806 BioC passages offsets6284,12476,15508,28097""}]"	"[{""id"": ""PMID:20050614"", ""source_sha256"": ""21fe7c6334e3578e17fe9805c32d06c8a2e05651fc883137246271f129feec13"", ""source_version"": ""2010; complete primary article HTML/BioC response; exact response bytes retrieved 2026-10-11 UTC"", ""title"": ""Structural determinants of substrate recognition in the HAD superfamily member D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB) ."", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC2844806/unicode""}, {""id"": ""PMID:20050615"", ""source_sha256"": ""06710bc051ad668f1bfd9d67c714b519af74e64e21c03bb36e44bf5e3d6accae"", ""source_version"": ""2010; complete primary article HTML/BioC response; exact response bytes retrieved 2026-10-11 UTC"", ""title"": ""Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB)."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2844805/""}, {""id"": ""RHEA:28519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 28519"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P63228"", ""source_sha256"": ""b7136a7b7b95873cb3414f4666db74bddfd487d2093d72c34203e7e868c76ce2"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; complete reviewed JSON retrieved 2026-10-11 UTC"", ""title"": ""D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P63228.json""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-023_d2be711e9881	MetaCyc:CPLX0-3661	pathwaymech:catalyzes	RHEA:27466	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-3661|PMID:11751812|RHEA:27466|UniProtKB:P76658		"[{""reference_id"": ""MetaCyc:CPLX0-3661"", ""source_assertion"": ""CPLX0-3661 has an explicit catalytic assignment to RXN0-4342."", ""source_locator"": ""Protein[@frameid=\""CPLX0-3661\""]/catalyzes/Enzymatic-Reaction/reaction/Reaction[@frameid=\""RXN0-4342\""]""}, {""reference_id"": ""UniProtKB:P76658"", ""source_assertion"": ""Reviewed K-12 P76658 CATALYTIC ACTIVITY gives RHEA:27465 and the corresponding equation with experimental ECO:0000269 evidence."", ""source_locator"": ""/organism/taxonId; /comments/3/reaction""}, {""reference_id"": ""RHEA:27466"", ""source_assertion"": ""Master RHEA:27465 explicitly links directionalReaction RHEA:27466, the left-to-right member in release 142."", ""source_locator"": ""http://rdf.rhea-db.org/27465 rh:directionalReaction http://rdf.rhea-db.org/27466; rhea-directions.tsv RHEA_ID_LR""}, {""reference_id"": ""PMID:11751812"", ""source_assertion"": ""K-12 HldE plus ATP activates synthetic beta-heptose 1-phosphate; alpha-heptose 1-phosphate and GTP controls do not yield the corresponding activation. Phosphatase activity is needed upstream in the coupled system. This is AMP transfer with diphosphate release."", ""source_locator"": ""PMC139585 HTML (//article//p)[23,25,29]; Figure 3""}]"	"[{""id"": ""MetaCyc:CPLX0-3661"", ""source_sha256"": ""ec6cb7464bf213dba096d84f7c93b28c33b6ec458463142c18848bb59bf9eaf1"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-3661""}, {""id"": ""PMID:11751812"", ""source_sha256"": ""fbcbc5a07e882efc3c230320e23ecd7a475b30fa4a4bc8d4707153138e850ef8"", ""source_version"": ""2002; complete primary article HTML/BioC response; exact response bytes retrieved 2026-10-11 UTC"", ""title"": ""Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC139585/""}, {""id"": ""RHEA:27466"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27466"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P76658"", ""source_sha256"": ""037ee3965f295c6fc72fcc7f6fbc2e8b01c4ec6037ba17b66d385f82166aec82"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; complete reviewed JSON retrieved 2026-10-11 UTC"", ""title"": ""Bifunctional protein HldE"", ""url"": ""https://rest.uniprot.org/uniprotkb/P76658.json""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-024_96b2ace2a0d0	MetaCyc:CPLX0-3681	pathwaymech:catalyzes	RHEA:17578	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-3681|PMID:7929099|RHEA:17578|UniProtKB:P67910	The selected biosynthetic direction does not assert irreversible chemistry.	"[{""reference_id"": ""MetaCyc:CPLX0-3681"", ""source_assertion"": ""CPLX0-3681 has an explicit catalytic assignment to 5.1.3.20-RXN."", ""source_locator"": ""Protein[@frameid=\""CPLX0-3681\""]/catalyzes/Enzymatic-Reaction/reaction/Reaction[@frameid=\""5.1.3.20-RXN\""]""}, {""reference_id"": ""UniProtKB:P67910"", ""source_assertion"": ""Reviewed K-12 P67910 CATALYTIC ACTIVITY gives RHEA:17577 and the corresponding equation with experimental ECO:0000269 evidence."", ""source_locator"": ""/organism/taxonId; /comments/1/reaction""}, {""reference_id"": ""RHEA:17578"", ""source_assertion"": ""Master RHEA:17577 explicitly links directionalReaction RHEA:17578, the left-to-right member in release 142."", ""source_locator"": ""http://rdf.rhea-db.org/17577 rh:directionalReaction http://rdf.rhea-db.org/17578; rhea-directions.tsv RHEA_ID_LR""}, {""reference_id"": ""PMID:7929099"", ""source_assertion"": ""The indexed primary abstract reports purified E. coli K-12 RfaD/HldD interconversion of the ADP-D- and ADP-L-glycero-D-manno-heptose epimers. Its historical NAD identification was subsequently refined by the 2001 NADP study."", ""source_locator"": ""/resultList/result[id=\""7929099\""]/abstractText""}]"	"[{""id"": ""MetaCyc:CPLX0-3681"", ""source_sha256"": ""6866bbb2104f22b19c1196bf8eff6afbccacf0ef906de5fb47a8770081c6b3f7"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ADP-L-glycero-D-mannoheptose 6-epimerase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-3681""}, {""id"": ""PMID:7929099"", ""source_sha256"": ""b65c62a4aaaeba840a04a14f4b1c0af1b8586513eb499fff811862d75b4d2dd2"", ""source_version"": ""1994; Europe PMC indexed primary abstract; digest covers complete core XML response, not full article retrieved 2026-10-11 UTC"", ""title"": ""Purification and properties of the Escherichia coli K-12 NAD-dependent nucleotide diphosphosugar epimerase, ADP-L-glycero-D-mannoheptose 6-epimerase."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7929099%20AND%20SRC:MED&resultType=core&format=xml""}, {""id"": ""RHEA:17578"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 17578"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P67910"", ""source_sha256"": ""69cd59f61f08f419be13aecee05553dfdea5b21e74d18a0e6d31066945c249a0"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; complete reviewed JSON retrieved 2026-10-11 UTC"", ""title"": ""ADP-L-glycero-D-manno-heptose-6-epimerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P67910.json""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-025_2a454621963d	UniProtKB:P63224	BFO:0000050	MetaCyc:CPLX0-7660	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7660|MetaCyc:G6106-MONOMER|PMID:18056714|UniProtKB:P63224	The native complex contains 4 identical subunits; the protein node is not independently assigned monomeric catalytic sufficiency.	"[{""reference_id"": ""MetaCyc:CPLX0-7660"", ""source_assertion"": ""The native assembly contains 4 copies of G6106-MONOMER."", ""source_locator"": ""Protein[@frameid=\""CPLX0-7660\""]/component/Protein; component/coefficient""}, {""reference_id"": ""MetaCyc:G6106-MONOMER"", ""source_assertion"": ""G6106-MONOMER explicitly unifies with UniProt P63224; the native organism is E. coli K-12 MG1655."", ""source_locator"": ""Protein[@frameid=\""G6106-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]; species/Organism""}, {""reference_id"": ""UniProtKB:P63224"", ""source_assertion"": ""SUBUNIT gives the 4-subunit homo-assembly with ECO:0000269 literature evidence."", ""source_locator"": ""/comments/5""}, {""reference_id"": ""PMID:18056714"", ""source_assertion"": ""Current curated assembly evidence cites the GmhA structural study; the inspected abstract describes quaternary rearrangement but does not independently specify tetramer stoichiometry."", ""source_locator"": ""/resultList/result[id=\""18056714\""]/abstractText""}]"	"[{""id"": ""MetaCyc:CPLX0-7660"", ""source_sha256"": ""654e02c7f2859815c92cef14f29298a8c30b038dedc86a97bf4bc0b27848d002"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""D-sedoheptulose 7-phosphate isomerase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7660""}, {""id"": ""MetaCyc:G6106-MONOMER"", ""source_sha256"": ""6cbc634ee94b951f29ad25e62e277ab13648e173aa8552fc11c824ff3e1e7cc8"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""G6106-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G6106-MONOMER""}, {""id"": ""PMID:18056714"", ""source_sha256"": ""8c810fb91735f8e1f9101f339d567c6d1b3da8931b880311819204ded7a37487"", ""source_version"": ""2008; Europe PMC indexed primary abstract; digest covers complete core XML response, not full article retrieved 2026-10-11 UTC"", ""title"": ""Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18056714%20AND%20SRC:MED&resultType=core&format=xml""}, {""id"": ""UniProtKB:P63224"", ""source_sha256"": ""33c3d881d53781ef0c0000d53918c2e4fd533fda609eff6c304028056ba2265a"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; complete reviewed JSON retrieved 2026-10-11 UTC"", ""title"": ""Phosphoheptose isomerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P63224.json""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-026_aa3a05cecd20	UniProtKB:P76658	BFO:0000050	MetaCyc:CPLX0-3661	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-3661|MetaCyc:G7590-MONOMER|PMID:16030223|UniProtKB:P76658	The native complex contains 2 identical subunits; the protein node is not independently assigned monomeric catalytic sufficiency.	"[{""reference_id"": ""MetaCyc:CPLX0-3661"", ""source_assertion"": ""The native assembly contains 2 copies of G7590-MONOMER."", ""source_locator"": ""Protein[@frameid=\""CPLX0-3661\""]/component/Protein; component/coefficient""}, {""reference_id"": ""MetaCyc:G7590-MONOMER"", ""source_assertion"": ""G7590-MONOMER explicitly unifies with UniProt P76658; the native organism is E. coli K-12 MG1655."", ""source_locator"": ""Protein[@frameid=\""G7590-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]; species/Organism""}, {""reference_id"": ""UniProtKB:P76658"", ""source_assertion"": ""SUBUNIT gives the 2-subunit homo-assembly with ECO:0000269 literature evidence."", ""source_locator"": ""/comments/7""}, {""reference_id"": ""PMID:16030223"", ""source_assertion"": ""Copurification and dominant-negative experiments support a functional HldE dimer. The gel-filtration dimer measurement in the abstract is specifically the isolated HldE1 kinase domain, not an independently repeated full-length HldE measurement."", ""source_locator"": ""/resultList/result[id=\""16030223\""]/abstractText""}]"	"[{""id"": ""MetaCyc:CPLX0-3661"", ""source_sha256"": ""ec6cb7464bf213dba096d84f7c93b28c33b6ec458463142c18848bb59bf9eaf1"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-3661""}, {""id"": ""MetaCyc:G7590-MONOMER"", ""source_sha256"": ""40fe6512f25562232b27eb899ce67464184808461ce21eaedc247f18fb70490c"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""G7590-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G7590-MONOMER""}, {""id"": ""PMID:16030223"", ""source_sha256"": ""f19c1a5d9e6521fbfa2bcad7bbf348d82bde856184434c6df9d7f5a284c007c5"", ""source_version"": ""2005; Europe PMC indexed primary abstract; digest covers complete core XML response, not full article retrieved 2026-10-11 UTC"", ""title"": ""Functional analysis of the glycero-manno-heptose 7-phosphate kinase domain from the bifunctional HldE protein, which is involved in ADP-L-glycero-D-manno-heptose biosynthesis."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16030223%20AND%20SRC:MED&resultType=core&format=xml""}, {""id"": ""UniProtKB:P76658"", ""source_sha256"": ""037ee3965f295c6fc72fcc7f6fbc2e8b01c4ec6037ba17b66d385f82166aec82"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; complete reviewed JSON retrieved 2026-10-11 UTC"", ""title"": ""Bifunctional protein HldE"", ""url"": ""https://rest.uniprot.org/uniprotkb/P76658.json""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-027_8f831352fcf3	UniProtKB:P67910	BFO:0000050	MetaCyc:CPLX0-3681	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-3681|MetaCyc:EG10838-MONOMER|PMID:10896473|UniProtKB:P67910	The native complex contains 5 identical subunits; the protein node is not independently assigned monomeric catalytic sufficiency.	"[{""reference_id"": ""MetaCyc:CPLX0-3681"", ""source_assertion"": ""The native assembly contains 5 copies of EG10838-MONOMER."", ""source_locator"": ""Protein[@frameid=\""CPLX0-3681\""]/component/Protein; component/coefficient""}, {""reference_id"": ""MetaCyc:EG10838-MONOMER"", ""source_assertion"": ""EG10838-MONOMER explicitly unifies with UniProt P67910; the native organism is E. coli K-12 MG1655."", ""source_locator"": ""Protein[@frameid=\""EG10838-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]; species/Organism""}, {""reference_id"": ""UniProtKB:P67910"", ""source_assertion"": ""SUBUNIT gives the 5-subunit homo-assembly with ECO:0000269 literature evidence."", ""source_locator"": ""/comments/7""}, {""reference_id"": ""PMID:10896473"", ""source_assertion"": ""The primary structure is a homopentamer with two pentamers in the crystallographic asymmetric unit; that is not evidence for a physiological decamer. Earlier apparent native mass does not itself resolve this stoichiometry."", ""source_locator"": ""/resultList/result[id=\""10896473\""]/abstractText""}]"	"[{""id"": ""MetaCyc:CPLX0-3681"", ""source_sha256"": ""6866bbb2104f22b19c1196bf8eff6afbccacf0ef906de5fb47a8770081c6b3f7"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ADP-L-glycero-D-mannoheptose 6-epimerase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-3681""}, {""id"": ""MetaCyc:EG10838-MONOMER"", ""source_sha256"": ""08acf4e78ee5bf360666b8a9a4b09f79429b2bc376bbe7599977d277db0a3b31"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""EG10838-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:EG10838-MONOMER""}, {""id"": ""PMID:10896473"", ""source_sha256"": ""6ea66820dc9e4156befdd46c282dbc02337611a560d51d2fd3f58709651bd3be"", ""source_version"": ""2000; Europe PMC indexed primary abstract; digest covers complete core XML response, not full article retrieved 2026-10-11 UTC"", ""title"": ""The crystal structure of ADP-L-glycero-D-mannoheptose 6-epimerase: catalysis with a twist."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10896473%20AND%20SRC:MED&resultType=core&format=xml""}, {""id"": ""UniProtKB:P67910"", ""source_sha256"": ""69cd59f61f08f419be13aecee05553dfdea5b21e74d18a0e6d31066945c249a0"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; complete reviewed JSON retrieved 2026-10-11 UTC"", ""title"": ""ADP-L-glycero-D-manno-heptose-6-epimerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P67910.json""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-028_947092bdf691	MetaCyc:CPLX0-7660	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P63224	Similarity-based cofactor annotation is retained with its evidence grade; no direct K-12 zinc requirement is inferred.	"[{""reference_id"": ""UniProtKB:P63224"", ""source_assertion"": ""COFACTOR annotates Zn(2+) and one zinc ion per subunit with ECO:0000250, an inference by similarity rather than direct evidence for zinc binding in this K-12 protein."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}]"	"[{""id"": ""UniProtKB:P63224"", ""source_sha256"": ""33c3d881d53781ef0c0000d53918c2e4fd533fda609eff6c304028056ba2265a"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; complete reviewed JSON retrieved 2026-10-11 UTC"", ""title"": ""Phosphoheptose isomerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P63224.json""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-029_2c264442d817	UniProtKB:P63228	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:20050614|UniProtKB:P63228	Catalytic divalent-metal alternatives are not simultaneous required occupancy. Dominant in vivo metal is not established by these annotations.	"[{""reference_id"": ""UniProtKB:P63228"", ""source_assertion"": ""COFACTOR explicitly includes Mg(2+); the note names magnesium and manganese/cobalt alternatives with ECO:0000269 PMID:16990279."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}, {""reference_id"": ""PMID:20050614"", ""source_assertion"": ""The E. coli GmhB substrate/product structures show the catalytic Mg coordination site. It is distinct from the Zn-binding loop site."", ""source_locator"": ""PMC2844806 BioC passages offsets15508,16641,17361; Figures 3-5""}]"	"[{""id"": ""PMID:20050614"", ""source_sha256"": ""21fe7c6334e3578e17fe9805c32d06c8a2e05651fc883137246271f129feec13"", ""source_version"": ""2010; complete primary article HTML/BioC response; exact response bytes retrieved 2026-10-11 UTC"", ""title"": ""Structural determinants of substrate recognition in the HAD superfamily member D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB) ."", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC2844806/unicode""}, {""id"": ""UniProtKB:P63228"", ""source_sha256"": ""b7136a7b7b95873cb3414f4666db74bddfd487d2093d72c34203e7e868c76ce2"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; complete reviewed JSON retrieved 2026-10-11 UTC"", ""title"": ""D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P63228.json""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-030_be0674507b0a	UniProtKB:P63228	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P63228	Catalytic divalent-metal alternatives are not simultaneous required occupancy. Dominant in vivo metal is not established by these annotations.	"[{""reference_id"": ""UniProtKB:P63228"", ""source_assertion"": ""COFACTOR explicitly includes Mn(2+); the note names magnesium and manganese/cobalt alternatives with ECO:0000269 PMID:16990279."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}]"	"[{""id"": ""UniProtKB:P63228"", ""source_sha256"": ""b7136a7b7b95873cb3414f4666db74bddfd487d2093d72c34203e7e868c76ce2"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; complete reviewed JSON retrieved 2026-10-11 UTC"", ""title"": ""D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P63228.json""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-031_f5cb3fd7e2a3	UniProtKB:P63228	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P63228	Catalytic divalent-metal alternatives are not simultaneous required occupancy. Dominant in vivo metal is not established by these annotations.	"[{""reference_id"": ""UniProtKB:P63228"", ""source_assertion"": ""COFACTOR explicitly includes Co(2+); the note names magnesium and manganese/cobalt alternatives with ECO:0000269 PMID:16990279."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}]"	"[{""id"": ""UniProtKB:P63228"", ""source_sha256"": ""b7136a7b7b95873cb3414f4666db74bddfd487d2093d72c34203e7e868c76ce2"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; complete reviewed JSON retrieved 2026-10-11 UTC"", ""title"": ""D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P63228.json""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-032_7af370f4e132	UniProtKB:P63228	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:20050614|UniProtKB:P63228	This bound Zn site is distinct from catalytic Mg. No universal Zn requirement or established physiological regulatory role is asserted.	"[{""reference_id"": ""UniProtKB:P63228"", ""source_assertion"": ""A separate COFACTOR statement annotates Zn(2+) with ECO:0000269 PMID:16990279."", ""source_locator"": ""/comments/3/cofactors""}, {""reference_id"": ""PMID:20050614"", ""source_assertion"": ""E. coli GmhB has a Zn-bound loop; Zn does not contact substrate or directly participate in catalysis in the inspected structure. Mutating coordinating residues is detrimental, but the paper leaves the origin and function of the motif unresolved."", ""source_locator"": ""PMC2844806 BioC passages offsets20251,21102,23631; Figure 6""}]"	"[{""id"": ""PMID:20050614"", ""source_sha256"": ""21fe7c6334e3578e17fe9805c32d06c8a2e05651fc883137246271f129feec13"", ""source_version"": ""2010; complete primary article HTML/BioC response; exact response bytes retrieved 2026-10-11 UTC"", ""title"": ""Structural determinants of substrate recognition in the HAD superfamily member D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB) ."", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC2844806/unicode""}, {""id"": ""UniProtKB:P63228"", ""source_sha256"": ""b7136a7b7b95873cb3414f4666db74bddfd487d2093d72c34203e7e868c76ce2"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; complete reviewed JSON retrieved 2026-10-11 UTC"", ""title"": ""D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P63228.json""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-033_70e950c9110a	MetaCyc:CPLX0-3681	pathwaymech:has_cofactor	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11313358|PMID:17316025|UniProtKB:P67910	NADP is the physiological bound cofactor; NAD is an alternative with lower activity. Neither is consumed in the balanced net epimerization.	"[{""reference_id"": ""UniProtKB:P67910"", ""source_assertion"": ""COFACTOR includes NADP(+); the note specifies one NADP per subunit and reduced activity when NAD substitutes, with experimental ECO:0000269 citations."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}, {""reference_id"": ""PMID:11313358"", ""source_assertion"": ""Apoenzyme reconstitution accepts NADP or NAD, but not FAD. Purified-enzyme extract analysis identifies NADP in vivo, refining the earlier NAD-only assignment."", ""source_locator"": ""/resultList/result[id=\""11313358\""]/abstractText""}, {""reference_id"": ""PMID:17316025"", ""source_assertion"": ""The E. coli K-12 mechanistic study describes initial C6 oxidation by bound NADP and subsequent reduction of the rotated keto intermediate; this is cofactor recycling during epimerization."", ""source_locator"": ""/resultList/result[id=\""17316025\""]/abstractText""}]"	"[{""id"": ""PMID:11313358"", ""source_sha256"": ""b6215feccae70c668dce94e58174cd3b21f98bd38b972681b42029f9e5aafec3"", ""source_version"": ""2001; Europe PMC indexed primary abstract; digest covers complete core XML response, not full article retrieved 2026-10-11 UTC"", ""title"": ""Evidence that NADP+ is the physiological cofactor of ADP-L-glycero-D-mannoheptose 6-epimerase."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11313358%20AND%20SRC:MED&resultType=core&format=xml""}, {""id"": ""PMID:17316025"", ""source_sha256"": ""aa01090a354e0b95ea548ea79542e6a0c55fdf966d209ed0a01c3e504b2112d1"", ""source_version"": ""2007; Europe PMC indexed primary abstract; digest covers complete core XML response, not full article retrieved 2026-10-11 UTC"", ""title"": ""A two-base mechanism for Escherichia coli ADP-L-glycero-D-manno-heptose 6-epimerase."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17316025%20AND%20SRC:MED&resultType=core&format=xml""}, {""id"": ""UniProtKB:P67910"", ""source_sha256"": ""69cd59f61f08f419be13aecee05553dfdea5b21e74d18a0e6d31066945c249a0"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; complete reviewed JSON retrieved 2026-10-11 UTC"", ""title"": ""ADP-L-glycero-D-manno-heptose-6-epimerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P67910.json""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-034_c5db3de9f458	MetaCyc:CPLX0-3681	pathwaymech:has_cofactor	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11313358|PMID:17316025|UniProtKB:P67910	NADP is the physiological bound cofactor; NAD is an alternative with lower activity. Neither is consumed in the balanced net epimerization.	"[{""reference_id"": ""UniProtKB:P67910"", ""source_assertion"": ""COFACTOR includes NAD(+); the note specifies one NADP per subunit and reduced activity when NAD substitutes, with experimental ECO:0000269 citations."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}, {""reference_id"": ""PMID:11313358"", ""source_assertion"": ""Apoenzyme reconstitution accepts NADP or NAD, but not FAD. Purified-enzyme extract analysis identifies NADP in vivo, refining the earlier NAD-only assignment."", ""source_locator"": ""/resultList/result[id=\""11313358\""]/abstractText""}, {""reference_id"": ""PMID:17316025"", ""source_assertion"": ""The E. coli K-12 mechanistic study describes initial C6 oxidation by bound NADP and subsequent reduction of the rotated keto intermediate; this is cofactor recycling during epimerization."", ""source_locator"": ""/resultList/result[id=\""17316025\""]/abstractText""}]"	"[{""id"": ""PMID:11313358"", ""source_sha256"": ""b6215feccae70c668dce94e58174cd3b21f98bd38b972681b42029f9e5aafec3"", ""source_version"": ""2001; Europe PMC indexed primary abstract; digest covers complete core XML response, not full article retrieved 2026-10-11 UTC"", ""title"": ""Evidence that NADP+ is the physiological cofactor of ADP-L-glycero-D-mannoheptose 6-epimerase."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11313358%20AND%20SRC:MED&resultType=core&format=xml""}, {""id"": ""PMID:17316025"", ""source_sha256"": ""aa01090a354e0b95ea548ea79542e6a0c55fdf966d209ed0a01c3e504b2112d1"", ""source_version"": ""2007; Europe PMC indexed primary abstract; digest covers complete core XML response, not full article retrieved 2026-10-11 UTC"", ""title"": ""A two-base mechanism for Escherichia coli ADP-L-glycero-D-manno-heptose 6-epimerase."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17316025%20AND%20SRC:MED&resultType=core&format=xml""}, {""id"": ""UniProtKB:P67910"", ""source_sha256"": ""69cd59f61f08f419be13aecee05553dfdea5b21e74d18a0e6d31066945c249a0"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; complete reviewed JSON retrieved 2026-10-11 UTC"", ""title"": ""ADP-L-glycero-D-manno-heptose-6-epimerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P67910.json""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-035_640ab6ea4163	RHEA:27490	BFO:0000050	MetaCyc:PWY0-1241	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1241|MetaCyc:RXN0-4301		"[{""reference_id"": ""MetaCyc:PWY0-1241"", ""source_assertion"": ""PWY0-1241 explicitly includes RXN0-4301; the native reaction layout selects L2R."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1241\""]/reaction-list; reaction-layout[Reaction/@frameid=\""RXN0-4301\""]/direction""}, {""reference_id"": ""MetaCyc:RXN0-4301"", ""source_assertion"": ""RXN0-4301 has explicit RHEA 27490 unification cross-reference."", ""source_locator"": ""Reaction[@frameid=\""RXN0-4301\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid; dblink-relationship""}]"	"[{""id"": ""MetaCyc:PWY0-1241"", ""source_sha256"": ""2e433fd5bebe45a88dc3f2b6b3d25aaa31ed3c54b06dfd15903dbbca71d3d5d7"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ADP-L-glycero-beta-D-manno-heptose biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1241""}, {""id"": ""MetaCyc:RXN0-4301"", ""source_sha256"": ""51a13b38fa047a0d04ac980e0a11e5dc00300a83c10d76ff2be35d1791d08d58"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""RXN0-4301"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-4301""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-036_a90cb74e4298	RHEA:27474	BFO:0000050	MetaCyc:PWY0-1241	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1241|MetaCyc:RXN0-4341		"[{""reference_id"": ""MetaCyc:PWY0-1241"", ""source_assertion"": ""PWY0-1241 explicitly includes RXN0-4341; the native reaction layout selects L2R."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1241\""]/reaction-list; reaction-layout[Reaction/@frameid=\""RXN0-4341\""]/direction""}, {""reference_id"": ""MetaCyc:RXN0-4341"", ""source_assertion"": ""RXN0-4341 has explicit RHEA 27474 unification cross-reference."", ""source_locator"": ""Reaction[@frameid=\""RXN0-4341\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid; dblink-relationship""}]"	"[{""id"": ""MetaCyc:PWY0-1241"", ""source_sha256"": ""2e433fd5bebe45a88dc3f2b6b3d25aaa31ed3c54b06dfd15903dbbca71d3d5d7"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ADP-L-glycero-beta-D-manno-heptose biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1241""}, {""id"": ""MetaCyc:RXN0-4341"", ""source_sha256"": ""654bab89e8aaa06054e2f39996ca15c11fb8120d44cfa865ac8504d0d12c2e49"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""RXN0-4341"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-4341""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-037_a6ae46174589	RHEA:28519	BFO:0000050	MetaCyc:PWY0-1241	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1241|MetaCyc:RXN0-4361		"[{""reference_id"": ""MetaCyc:PWY0-1241"", ""source_assertion"": ""PWY0-1241 explicitly includes RXN0-4361; the native reaction layout selects L2R."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1241\""]/reaction-list; reaction-layout[Reaction/@frameid=\""RXN0-4361\""]/direction""}, {""reference_id"": ""MetaCyc:RXN0-4361"", ""source_assertion"": ""RXN0-4361 has explicit RHEA 28519 unification cross-reference."", ""source_locator"": ""Reaction[@frameid=\""RXN0-4361\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid; dblink-relationship""}]"	"[{""id"": ""MetaCyc:PWY0-1241"", ""source_sha256"": ""2e433fd5bebe45a88dc3f2b6b3d25aaa31ed3c54b06dfd15903dbbca71d3d5d7"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ADP-L-glycero-beta-D-manno-heptose biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1241""}, {""id"": ""MetaCyc:RXN0-4361"", ""source_sha256"": ""14cf18ec9de3a18eb5beb7ffbbce6a86432ee13bd509564f2ff576de3c20294b"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""RXN0-4361"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-4361""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-038_39feb5d4c7b1	RHEA:27466	BFO:0000050	MetaCyc:PWY0-1241	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1241|MetaCyc:RXN0-4342		"[{""reference_id"": ""MetaCyc:PWY0-1241"", ""source_assertion"": ""PWY0-1241 explicitly includes RXN0-4342; the native reaction layout selects L2R."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1241\""]/reaction-list; reaction-layout[Reaction/@frameid=\""RXN0-4342\""]/direction""}, {""reference_id"": ""MetaCyc:RXN0-4342"", ""source_assertion"": ""RXN0-4342 has explicit RHEA 27466 unification cross-reference."", ""source_locator"": ""Reaction[@frameid=\""RXN0-4342\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid; dblink-relationship""}]"	"[{""id"": ""MetaCyc:PWY0-1241"", ""source_sha256"": ""2e433fd5bebe45a88dc3f2b6b3d25aaa31ed3c54b06dfd15903dbbca71d3d5d7"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ADP-L-glycero-beta-D-manno-heptose biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1241""}, {""id"": ""MetaCyc:RXN0-4342"", ""source_sha256"": ""7af94ad1e125ca10e9d93dce4ed33b3097571dfbfab64c388bf6db8145621792"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""RXN0-4342"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-4342""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-039_0c4d5c45f036	RHEA:17578	BFO:0000050	MetaCyc:PWY0-1241	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:5.1.3.20-RXN|MetaCyc:PWY0-1241		"[{""reference_id"": ""MetaCyc:PWY0-1241"", ""source_assertion"": ""PWY0-1241 explicitly includes 5.1.3.20-RXN; the native reaction layout selects L2R."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1241\""]/reaction-list; reaction-layout[Reaction/@frameid=\""5.1.3.20-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:5.1.3.20-RXN"", ""source_assertion"": ""5.1.3.20-RXN has explicit RHEA 17578 unification cross-reference."", ""source_locator"": ""Reaction[@frameid=\""5.1.3.20-RXN\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid; dblink-relationship""}]"	"[{""id"": ""MetaCyc:5.1.3.20-RXN"", ""source_sha256"": ""c54daf635091cbb0762e32ead3c9d4bb7c11a69e361df035cf25821592c7c6b9"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""5.1.3.20-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:5.1.3.20-RXN""}, {""id"": ""MetaCyc:PWY0-1241"", ""source_sha256"": ""2e433fd5bebe45a88dc3f2b6b3d25aaa31ed3c54b06dfd15903dbbca71d3d5d7"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ADP-L-glycero-beta-D-manno-heptose biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1241""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-040_755e4ab30a1f	RHEA:27490	RO:0002413	RHEA:27474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1241|RHEA:27474|RHEA:27490	A shared chemical and native predecessor relation establish this sequence; no physical channeling or obligatory enzyme complex is inferred.	"[{""reference_id"": ""MetaCyc:PWY0-1241"", ""source_assertion"": ""RXN0-4341 has RXN0-4301 as its explicit predecessor in PWY0-1241."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1241\""]/reaction-ordering""}, {""reference_id"": ""RHEA:27490"", ""source_assertion"": ""RHEA:27490 produces CHEBI:60204, the shared intermediate consumed by the next selected reaction."", ""source_locator"": ""http://rdf.rhea-db.org/27490 rh:products; rh:contains1""}, {""reference_id"": ""RHEA:27474"", ""source_assertion"": ""RHEA:27474 consumes CHEBI:60204."", ""source_locator"": ""http://rdf.rhea-db.org/27474 rh:substrates; rh:contains1""}]"	"[{""id"": ""MetaCyc:PWY0-1241"", ""source_sha256"": ""2e433fd5bebe45a88dc3f2b6b3d25aaa31ed3c54b06dfd15903dbbca71d3d5d7"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ADP-L-glycero-beta-D-manno-heptose biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1241""}, {""id"": ""RHEA:27474"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27474"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:27490"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27490"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-041_eb578f46de97	RHEA:27474	RO:0002413	RHEA:28519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1241|RHEA:27474|RHEA:28519	A shared chemical and native predecessor relation establish this sequence; no physical channeling or obligatory enzyme complex is inferred.	"[{""reference_id"": ""MetaCyc:PWY0-1241"", ""source_assertion"": ""RXN0-4361 has RXN0-4341 as its explicit predecessor in PWY0-1241."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1241\""]/reaction-ordering""}, {""reference_id"": ""RHEA:27474"", ""source_assertion"": ""RHEA:27474 produces CHEBI:60208, the shared intermediate consumed by the next selected reaction."", ""source_locator"": ""http://rdf.rhea-db.org/27474 rh:products; rh:contains1""}, {""reference_id"": ""RHEA:28519"", ""source_assertion"": ""RHEA:28519 consumes CHEBI:60208."", ""source_locator"": ""http://rdf.rhea-db.org/28519 rh:substrates; rh:contains1""}]"	"[{""id"": ""MetaCyc:PWY0-1241"", ""source_sha256"": ""2e433fd5bebe45a88dc3f2b6b3d25aaa31ed3c54b06dfd15903dbbca71d3d5d7"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ADP-L-glycero-beta-D-manno-heptose biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1241""}, {""id"": ""RHEA:27474"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27474"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:28519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 28519"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-042_a842a84cb7f3	RHEA:28519	RO:0002413	RHEA:27466	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1241|RHEA:27466|RHEA:28519	A shared chemical and native predecessor relation establish this sequence; no physical channeling or obligatory enzyme complex is inferred.	"[{""reference_id"": ""MetaCyc:PWY0-1241"", ""source_assertion"": ""RXN0-4342 has RXN0-4361 as its explicit predecessor in PWY0-1241."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1241\""]/reaction-ordering""}, {""reference_id"": ""RHEA:28519"", ""source_assertion"": ""RHEA:28519 produces CHEBI:61593, the shared intermediate consumed by the next selected reaction."", ""source_locator"": ""http://rdf.rhea-db.org/28519 rh:products; rh:contains1""}, {""reference_id"": ""RHEA:27466"", ""source_assertion"": ""RHEA:27466 consumes CHEBI:61593."", ""source_locator"": ""http://rdf.rhea-db.org/27466 rh:substrates; rh:contains1""}]"	"[{""id"": ""MetaCyc:PWY0-1241"", ""source_sha256"": ""2e433fd5bebe45a88dc3f2b6b3d25aaa31ed3c54b06dfd15903dbbca71d3d5d7"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ADP-L-glycero-beta-D-manno-heptose biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1241""}, {""id"": ""RHEA:27466"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27466"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:28519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 28519"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1241_adhp-edge-043_d9728894985b	RHEA:27466	RO:0002413	RHEA:17578	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1241|RHEA:17578|RHEA:27466	A shared chemical and native predecessor relation establish this sequence; no physical channeling or obligatory enzyme complex is inferred.	"[{""reference_id"": ""MetaCyc:PWY0-1241"", ""source_assertion"": ""5.1.3.20-RXN has RXN0-4342 as its explicit predecessor in PWY0-1241."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1241\""]/reaction-ordering""}, {""reference_id"": ""RHEA:27466"", ""source_assertion"": ""RHEA:27466 produces CHEBI:59967, the shared intermediate consumed by the next selected reaction."", ""source_locator"": ""http://rdf.rhea-db.org/27466 rh:products; rh:contains1""}, {""reference_id"": ""RHEA:17578"", ""source_assertion"": ""RHEA:17578 consumes CHEBI:59967."", ""source_locator"": ""http://rdf.rhea-db.org/17578 rh:substrates; rh:contains1""}]"	"[{""id"": ""MetaCyc:PWY0-1241"", ""source_sha256"": ""2e433fd5bebe45a88dc3f2b6b3d25aaa31ed3c54b06dfd15903dbbca71d3d5d7"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ADP-L-glycero-beta-D-manno-heptose biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1241""}, {""id"": ""RHEA:17578"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 17578"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:27466"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF, with exact reaction and side locators in evidence"", ""title"": ""Rhea directional reaction 27466"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-001_c676579ae8f3	CHEBI:32551	pathwaymech:consumes	RHEA:23229	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23229		"[{""reference_id"": ""RHEA:23229"", ""source_assertion"": ""RHEA:23229 assigns CHEBI:32551 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23229 rh:substrates http://rdf.rhea-db.org/23228_L; http://rdf.rhea-db.org/23228_L rh:contains1 http://rdf.rhea-db.org/Participant_23228_compound_3235; rh:compound http://rdf.rhea-db.org/Compound_3235; rh:chebi""}]"	"[{""id"": ""RHEA:23229"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 23229"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-002_510df9e7fee4	CHEBI:57783	pathwaymech:consumes	RHEA:23229	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23229		"[{""reference_id"": ""RHEA:23229"", ""source_assertion"": ""RHEA:23229 assigns CHEBI:57783 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23229 rh:substrates http://rdf.rhea-db.org/23228_L; http://rdf.rhea-db.org/23228_L rh:contains1 http://rdf.rhea-db.org/Participant_23228_compound_3438; rh:compound http://rdf.rhea-db.org/Compound_3438; rh:chebi""}]"	"[{""id"": ""RHEA:23229"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 23229"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-003_355975d7bf45	CHEBI:15379	pathwaymech:consumes	RHEA:23229	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23229		"[{""reference_id"": ""RHEA:23229"", ""source_assertion"": ""RHEA:23229 assigns CHEBI:15379 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23229 rh:substrates http://rdf.rhea-db.org/23228_L; http://rdf.rhea-db.org/23228_L rh:contains1 http://rdf.rhea-db.org/Participant_23228_compound_1198; rh:compound http://rdf.rhea-db.org/Compound_1198; rh:chebi""}]"	"[{""id"": ""RHEA:23229"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 23229"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-004_6ca3c54317a3	RHEA:23229	pathwaymech:produces	CHEBI:57820	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23229		"[{""reference_id"": ""RHEA:23229"", ""source_assertion"": ""RHEA:23229 assigns CHEBI:57820 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23229 rh:products http://rdf.rhea-db.org/23228_R; http://rdf.rhea-db.org/23228_R rh:contains1 http://rdf.rhea-db.org/Participant_23228_compound_2821; rh:compound http://rdf.rhea-db.org/Compound_2821; rh:chebi""}]"	"[{""id"": ""RHEA:23229"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 23229"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-005_b68cc892f30e	RHEA:23229	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23229		"[{""reference_id"": ""RHEA:23229"", ""source_assertion"": ""RHEA:23229 assigns CHEBI:58349 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23229 rh:products http://rdf.rhea-db.org/23228_R; http://rdf.rhea-db.org/23228_R rh:contains1 http://rdf.rhea-db.org/Participant_23228_compound_5188; rh:compound http://rdf.rhea-db.org/Compound_5188; rh:chebi""}]"	"[{""id"": ""RHEA:23229"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 23229"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-006_c1d8046c16c1	RHEA:23229	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23229		"[{""reference_id"": ""RHEA:23229"", ""source_assertion"": ""RHEA:23229 assigns CHEBI:15377 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23229 rh:products http://rdf.rhea-db.org/23228_R; http://rdf.rhea-db.org/23228_R rh:contains1 http://rdf.rhea-db.org/Participant_23228_compound_1283; rh:compound http://rdf.rhea-db.org/Compound_1283; rh:chebi""}]"	"[{""id"": ""RHEA:23229"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 23229"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-007_1f08d91ffbe1	CHEBI:57820	pathwaymech:consumes	RHEA:22389	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22389		"[{""reference_id"": ""RHEA:22389"", ""source_assertion"": ""RHEA:22389 assigns CHEBI:57820 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22389 rh:substrates http://rdf.rhea-db.org/22388_L; http://rdf.rhea-db.org/22388_L rh:contains1 http://rdf.rhea-db.org/Participant_22388_compound_2821; rh:compound http://rdf.rhea-db.org/Compound_2821; rh:chebi""}]"	"[{""id"": ""RHEA:22389"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 22389"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-008_77f5b40f1606	CHEBI:57288	pathwaymech:consumes	RHEA:22389	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22389		"[{""reference_id"": ""RHEA:22389"", ""source_assertion"": ""RHEA:22389 assigns CHEBI:57288 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22389 rh:substrates http://rdf.rhea-db.org/22388_L; http://rdf.rhea-db.org/22388_L rh:contains1 http://rdf.rhea-db.org/Participant_22388_compound_4271; rh:compound http://rdf.rhea-db.org/Compound_4271; rh:chebi""}]"	"[{""id"": ""RHEA:22389"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 22389"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-009_6690bc35879c	RHEA:22389	pathwaymech:produces	CHEBI:58122	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22389		"[{""reference_id"": ""RHEA:22389"", ""source_assertion"": ""RHEA:22389 assigns CHEBI:58122 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22389 rh:products http://rdf.rhea-db.org/22388_R; http://rdf.rhea-db.org/22388_R rh:contains1 http://rdf.rhea-db.org/Participant_22388_compound_4878; rh:compound http://rdf.rhea-db.org/Compound_4878; rh:chebi""}]"	"[{""id"": ""RHEA:22389"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 22389"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-010_72c51af48746	RHEA:22389	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22389		"[{""reference_id"": ""RHEA:22389"", ""source_assertion"": ""RHEA:22389 assigns CHEBI:57287 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22389 rh:products http://rdf.rhea-db.org/22388_R; http://rdf.rhea-db.org/22388_R rh:contains1 http://rdf.rhea-db.org/Participant_22388_compound_1264; rh:compound http://rdf.rhea-db.org/Compound_1264; rh:chebi""}]"	"[{""id"": ""RHEA:22389"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 22389"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-011_69c1a0621ee8	CHEBI:58122	pathwaymech:consumes	RHEA:32164	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:32164		"[{""reference_id"": ""RHEA:32164"", ""source_assertion"": ""RHEA:32164 assigns CHEBI:58122 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/32164 rh:substrates http://rdf.rhea-db.org/32163_L; http://rdf.rhea-db.org/32163_L rh:contains1 http://rdf.rhea-db.org/Participant_32163_compound_4878; rh:compound http://rdf.rhea-db.org/Compound_4878; rh:chebi""}]"	"[{""id"": ""RHEA:32164"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32164"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-012_1c6e366cc7fb	CHEBI:16947	pathwaymech:consumes	RHEA:32164	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:32164		"[{""reference_id"": ""RHEA:32164"", ""source_assertion"": ""RHEA:32164 assigns CHEBI:16947 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/32164 rh:substrates http://rdf.rhea-db.org/32163_L; http://rdf.rhea-db.org/32163_L rh:contains1 http://rdf.rhea-db.org/Participant_32163_compound_5244; rh:compound http://rdf.rhea-db.org/Compound_5244; rh:chebi""}]"	"[{""id"": ""RHEA:32164"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32164"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-013_f2767c0a7362	CHEBI:30616	pathwaymech:consumes	RHEA:32164	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:32164		"[{""reference_id"": ""RHEA:32164"", ""source_assertion"": ""RHEA:32164 assigns CHEBI:30616 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/32164 rh:substrates http://rdf.rhea-db.org/32163_L; http://rdf.rhea-db.org/32163_L rh:contains1 http://rdf.rhea-db.org/Participant_32163_compound_6372; rh:compound http://rdf.rhea-db.org/Compound_6372; rh:chebi""}]"	"[{""id"": ""RHEA:32164"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32164"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-014_2aeda20c8937	RHEA:32164	pathwaymech:produces	CHEBI:63796	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:63796|PMID:29618511|RHEA:32164	CHEBI:63796 is the issued lysine-S class with unspecified citrate-derived stereocenter. The hvKP1 experiments select its 3S,2′S member; this graph does not assert acceptance of the 3R member or an exact stereochemical identity between the class and that measured product.	"[{""reference_id"": ""RHEA:32164"", ""source_assertion"": ""RHEA:32164 assigns CHEBI:63796 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/32164 rh:products http://rdf.rhea-db.org/32163_R; http://rdf.rhea-db.org/32163_R rh:contains1 http://rdf.rhea-db.org/Participant_32163_compound_7047; rh:compound http://rdf.rhea-db.org/Compound_7047; rh:chebi""}, {""reference_id"": ""CHEBI:63796"", ""source_assertion"": ""The authoritative InChI fixes the lysine stereocenter but leaves the citrate-derived center unspecified (/t9-,14?/m0/s1)."", ""source_locator"": ""statements[subject=CHEBI:63796,predicate=chemrof:inchi_string]""}, {""reference_id"": ""PMID:29618511"", ""source_assertion"": ""IucA produced and IucC consumed the 3S,2′S citryl-ahLys stereoisomer in the hvKP1 enzyme experiments."", ""source_locator"": ""PMC5961048 Results/Aerobactin synthetase stereoselectivity, sec6/p[1]; Figure 5; original PDF p.7844""}]"	"[{""id"": ""CHEBI:63796"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers the uncompressed original Semantic SQL database"", ""title"": ""ChEBI N(alpha)-citryl-N(epsilon)-acetyl-N(epsilon)-hydroxylysine(3-)"", ""url"": ""https://ftp.ebi.ac.uk/pub/databases/chebi/ontology/""}, {""id"": ""PMID:29618511"", ""source_sha256"": ""c77b02de555a96e8cce88e3d6000a3231d8a1f0e5a9efdbc7fd753637109256c"", ""source_version"": ""Original research article; retained PMC HTML retrieved 2026-10-11"", ""title"": ""Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC5961048/""}, {""id"": ""RHEA:32164"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32164"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-015_6987deb766df	RHEA:32164	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:32164		"[{""reference_id"": ""RHEA:32164"", ""source_assertion"": ""RHEA:32164 assigns CHEBI:456215 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/32164 rh:products http://rdf.rhea-db.org/32163_R; http://rdf.rhea-db.org/32163_R rh:contains1 http://rdf.rhea-db.org/Participant_32163_compound_2590; rh:compound http://rdf.rhea-db.org/Compound_2590; rh:chebi""}]"	"[{""id"": ""RHEA:32164"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32164"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-016_fa829a188128	RHEA:32164	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:32164		"[{""reference_id"": ""RHEA:32164"", ""source_assertion"": ""RHEA:32164 assigns CHEBI:33019 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/32164 rh:products http://rdf.rhea-db.org/32163_R; http://rdf.rhea-db.org/32163_R rh:contains1 http://rdf.rhea-db.org/Participant_32163_compound_2106; rh:compound http://rdf.rhea-db.org/Compound_2106; rh:chebi""}]"	"[{""id"": ""RHEA:32164"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32164"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-017_213468cfc9ba	RHEA:32164	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:32164		"[{""reference_id"": ""RHEA:32164"", ""source_assertion"": ""RHEA:32164 assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/32164 rh:products http://rdf.rhea-db.org/32163_R; http://rdf.rhea-db.org/32163_R rh:contains1 http://rdf.rhea-db.org/Participant_32163_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:32164"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32164"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-018_22ff86b8d236	CHEBI:63796	pathwaymech:consumes	RHEA:32168	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:63796|PMID:29618511|RHEA:32168	CHEBI:63796 is the issued lysine-S class with unspecified citrate-derived stereocenter. The hvKP1 experiments select its 3S,2′S member; this graph does not assert acceptance of the 3R member or an exact stereochemical identity between the class and that measured product.	"[{""reference_id"": ""RHEA:32168"", ""source_assertion"": ""RHEA:32168 assigns CHEBI:63796 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/32168 rh:substrates http://rdf.rhea-db.org/32167_L; http://rdf.rhea-db.org/32167_L rh:contains1 http://rdf.rhea-db.org/Participant_32167_compound_7047; rh:compound http://rdf.rhea-db.org/Compound_7047; rh:chebi""}, {""reference_id"": ""CHEBI:63796"", ""source_assertion"": ""The authoritative InChI fixes the lysine stereocenter but leaves the citrate-derived center unspecified (/t9-,14?/m0/s1)."", ""source_locator"": ""statements[subject=CHEBI:63796,predicate=chemrof:inchi_string]""}, {""reference_id"": ""PMID:29618511"", ""source_assertion"": ""IucA produced and IucC consumed the 3S,2′S citryl-ahLys stereoisomer in the hvKP1 enzyme experiments."", ""source_locator"": ""PMC5961048 Results/Aerobactin synthetase stereoselectivity, sec6/p[1]; Figure 5; original PDF p.7844""}]"	"[{""id"": ""CHEBI:63796"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers the uncompressed original Semantic SQL database"", ""title"": ""ChEBI N(alpha)-citryl-N(epsilon)-acetyl-N(epsilon)-hydroxylysine(3-)"", ""url"": ""https://ftp.ebi.ac.uk/pub/databases/chebi/ontology/""}, {""id"": ""PMID:29618511"", ""source_sha256"": ""c77b02de555a96e8cce88e3d6000a3231d8a1f0e5a9efdbc7fd753637109256c"", ""source_version"": ""Original research article; retained PMC HTML retrieved 2026-10-11"", ""title"": ""Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC5961048/""}, {""id"": ""RHEA:32168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32168"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-019_029422a5e9a8	CHEBI:58122	pathwaymech:consumes	RHEA:32168	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:32168		"[{""reference_id"": ""RHEA:32168"", ""source_assertion"": ""RHEA:32168 assigns CHEBI:58122 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/32168 rh:substrates http://rdf.rhea-db.org/32167_L; http://rdf.rhea-db.org/32167_L rh:contains1 http://rdf.rhea-db.org/Participant_32167_compound_4878; rh:compound http://rdf.rhea-db.org/Compound_4878; rh:chebi""}]"	"[{""id"": ""RHEA:32168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32168"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-020_e304c635bff1	CHEBI:30616	pathwaymech:consumes	RHEA:32168	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:32168		"[{""reference_id"": ""RHEA:32168"", ""source_assertion"": ""RHEA:32168 assigns CHEBI:30616 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/32168 rh:substrates http://rdf.rhea-db.org/32167_L; http://rdf.rhea-db.org/32167_L rh:contains1 http://rdf.rhea-db.org/Participant_32167_compound_6372; rh:compound http://rdf.rhea-db.org/Compound_6372; rh:chebi""}]"	"[{""id"": ""RHEA:32168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32168"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-021_1fc4c8c387ac	RHEA:32168	pathwaymech:produces	CHEBI:58396	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:32168		"[{""reference_id"": ""RHEA:32168"", ""source_assertion"": ""RHEA:32168 assigns CHEBI:58396 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/32168 rh:products http://rdf.rhea-db.org/32167_R; http://rdf.rhea-db.org/32167_R rh:contains1 http://rdf.rhea-db.org/Participant_32167_compound_4057; rh:compound http://rdf.rhea-db.org/Compound_4057; rh:chebi""}]"	"[{""id"": ""RHEA:32168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32168"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-022_5240e8023290	RHEA:32168	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:32168		"[{""reference_id"": ""RHEA:32168"", ""source_assertion"": ""RHEA:32168 assigns CHEBI:456215 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/32168 rh:products http://rdf.rhea-db.org/32167_R; http://rdf.rhea-db.org/32167_R rh:contains1 http://rdf.rhea-db.org/Participant_32167_compound_2590; rh:compound http://rdf.rhea-db.org/Compound_2590; rh:chebi""}]"	"[{""id"": ""RHEA:32168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32168"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-023_321f58eaab93	RHEA:32168	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:32168		"[{""reference_id"": ""RHEA:32168"", ""source_assertion"": ""RHEA:32168 assigns CHEBI:33019 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/32168 rh:products http://rdf.rhea-db.org/32167_R; http://rdf.rhea-db.org/32167_R rh:contains1 http://rdf.rhea-db.org/Participant_32167_compound_2106; rh:compound http://rdf.rhea-db.org/Compound_2106; rh:chebi""}]"	"[{""id"": ""RHEA:32168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32168"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-024_2172579e8ef4	RHEA:32168	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:32168		"[{""reference_id"": ""RHEA:32168"", ""source_assertion"": ""RHEA:32168 assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/32168 rh:products http://rdf.rhea-db.org/32167_R; http://rdf.rhea-db.org/32167_R rh:contains1 http://rdf.rhea-db.org/Participant_32167_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:32168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32168"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-025_9984f3a1b4d0	NCBIProtein:EMB09147.1	pathwaymech:enables	RHEA:23229	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:EMB09147.1|PMID:29618511	The hvKP1 IucD preparation supplied the lysine hydroxylation step in the four-enzyme reconstruction; Figure 1 assigns NADPH, oxygen and FAD to this step. Free hydroxylysine was not detected in the IucD-only assay, so that observation is not claimed as direct product identification.	"[{""reference_id"": ""NCBIProtein:EMB09147.1"", ""source_assertion"": ""The original GenPept entry EMB09147.1 identifies the hvKP1 gene product and its native protein sequence; function is supplied by the separately cited primary experiments."", ""source_locator"": ""GBSeq[GBSeq_accession-version='EMB09147.1']/GBSeq_source; GBSeq_feature-table/GBFeature[GBFeature_key='CDS']; GBSeq_sequence""}, {""reference_id"": ""PMID:29618511"", ""source_assertion"": ""Figure 1 places IucD at lysine N6 hydroxylation; Results report the hvKP1 four-protein reconstitution and the unobserved free hydroxylysine intermediate."", ""source_locator"": ""PMC5961048 Figure 1; Results/sec4 (In vitro aerobactin reconstitution), Figure 3; Discussion/sec10/p[2]; Experimental procedures/sec12/p[1]""}]"	"[{""id"": ""NCBIProtein:EMB09147.1"", ""source_sha256"": ""b0d21b01a6cd2e85625bd1713fafd2def712e80db63f7fefea5d17049c21776b"", ""source_version"": ""NCBI GenPept original four-record batch retrieved 2026-10-11; hash covers complete batch; entries updated 2013-02-07"", ""title"": ""IucD [Klebsiella pneumoniae hvKP1]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=EMB09144.1,EMB09145.1,EMB09146.1,EMB09147.1&retmode=xml""}, {""id"": ""PMID:29618511"", ""source_sha256"": ""c77b02de555a96e8cce88e3d6000a3231d8a1f0e5a9efdbc7fd753637109256c"", ""source_version"": ""Original research article; retained PMC HTML retrieved 2026-10-11"", ""title"": ""Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC5961048/""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-026_01ed6c66b360	NCBIProtein:EMB09145.1	pathwaymech:enables	RHEA:22389	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:EMB09145.1|PMID:29618511	The hvKP1 IucB preparation, together with IucD, produced N6-acetyl-N6-hydroxylysine in the reconstructed pathway. The assay used a cleavable fusion preparation; the E. coli native IucB hexamer annotation is not transferred to this hvKP1 protein.	"[{""reference_id"": ""NCBIProtein:EMB09145.1"", ""source_assertion"": ""The original GenPept entry EMB09145.1 identifies the hvKP1 gene product and its native protein sequence; function is supplied by the separately cited primary experiments."", ""source_locator"": ""GBSeq[GBSeq_accession-version='EMB09145.1']/GBSeq_source; GBSeq_feature-table/GBFeature[GBFeature_key='CDS']; GBSeq_sequence""}, {""reference_id"": ""PMID:29618511"", ""source_assertion"": ""IucD plus IucB produced the acetylated hydroxylated lysine building block; the four proteins were derived from hvKP1."", ""source_locator"": ""PMC5961048 Figure 1; Results/sec4 (In vitro aerobactin reconstitution), Figure 3; Discussion/sec10/p[2]; Experimental procedures/sec12/p[1]""}]"	"[{""id"": ""NCBIProtein:EMB09145.1"", ""source_sha256"": ""b0d21b01a6cd2e85625bd1713fafd2def712e80db63f7fefea5d17049c21776b"", ""source_version"": ""NCBI GenPept original four-record batch retrieved 2026-10-11; hash covers complete batch; entries updated 2013-02-07"", ""title"": ""IucB [Klebsiella pneumoniae hvKP1]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=EMB09144.1,EMB09145.1,EMB09146.1,EMB09147.1&retmode=xml""}, {""id"": ""PMID:29618511"", ""source_sha256"": ""c77b02de555a96e8cce88e3d6000a3231d8a1f0e5a9efdbc7fd753637109256c"", ""source_version"": ""Original research article; retained PMC HTML retrieved 2026-10-11"", ""title"": ""Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC5961048/""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-027_0c37e746b8a3	NCBIProtein:EMB09144.1	pathwaymech:enables	RHEA:32164	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EC:6.3.2.38|NCBIProtein:EMB09144.1|PMID:27253399|PMID:29618511|PMID:32432457	The hvKP1 IucA gene product enables the first citrate ligation. Direct solution measurements support a tetramer of the selected 574-residue protein. This gene-product role does not claim monomer sufficiency. Both substrate selection and stereoselectivity were tested in the complete pathway study.	"[{""reference_id"": ""NCBIProtein:EMB09144.1"", ""source_assertion"": ""The original GenPept entry EMB09144.1 identifies the hvKP1 gene product and its native protein sequence; function is supplied by the separately cited primary experiments."", ""source_locator"": ""GBSeq[GBSeq_accession-version='EMB09144.1']/GBSeq_source; GBSeq_feature-table/GBFeature[GBFeature_key='CDS']; GBSeq_sequence""}, {""reference_id"": ""PMID:29618511"", ""source_assertion"": ""Adding IucA to IucD and IucB generated citryl-ahLys; adding IucC completed aerobactin synthesis in the hvKP1 system."", ""source_locator"": ""PMC5961048 Figure 1; Results/sec4 (In vitro aerobactin reconstitution), Figure 3; Discussion/sec10/p[2]; Experimental procedures/sec12/p[1]""}, {""reference_id"": ""PMID:27253399"", ""source_assertion"": ""The experimentally selected hvKP1 IucA is explicitly EMB09144.1 (574 residues); native gel, size exclusion and SAXS support a tetramer despite a computational monomer prediction."", ""source_locator"": ""PMC4928626 Methods/sec2.1/p[1] (Cloning, Expression, and Purification of hvKP IucA); Results/sec3.3 (Quaternary Structure), Figures 4-6""}, {""reference_id"": ""PMID:32432457"", ""source_assertion"": ""IucA forms the citryl-adenylate intermediate and then the amide product with AMP and diphosphate; the data support sequential ATP, citrate and ahLys binding."", ""source_locator"": ""PMC7325057 Methods/S8/P16; Results/S11/P31; Discussion/S14/P40""}, {""reference_id"": ""EC:6.3.2.38"", ""source_assertion"": ""The Reaction field instead lists 2 ATP plus water yielding 2 ADP and 2 phosphates, despite an AMP-forming systematic name. That conflicting database equation is not the selected Rhea/native representation."", ""source_locator"": ""ExplorEnz EC6.3.2.38 fields Reaction, Systematic name and Comments""}]"	"[{""id"": ""EC:6.3.2.38"", ""source_sha256"": ""a9b8b5a163399264bcb2b75b6066286a54679be997c4af832643f0be087e78ab"", ""source_version"": ""Original ExplorEnz HTML retrieved 2026-10-11; entry last modified 2019"", ""title"": ""IUBMB ExplorEnz EC 6.3.2.38"", ""url"": ""https://www.enzyme-database.org/query.php?ec=6.3.2.38""}, {""id"": ""NCBIProtein:EMB09144.1"", ""source_sha256"": ""b0d21b01a6cd2e85625bd1713fafd2def712e80db63f7fefea5d17049c21776b"", ""source_version"": ""NCBI GenPept original four-record batch retrieved 2026-10-11; hash covers complete batch; entries updated 2013-02-07"", ""title"": ""hypothetical protein G057_19877 [Klebsiella pneumoniae hvKP1]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=EMB09144.1,EMB09145.1,EMB09146.1,EMB09147.1&retmode=xml""}, {""id"": ""PMID:27253399"", ""source_sha256"": ""2084bc473dde1a33306f2f0b0c1cfc55d7d061bafd3ba3bdfac6b80619586db8"", ""source_version"": ""Original research article; retained PMC HTML retrieved 2026-10-11"", ""title"": ""Structural and Functional Characterization of Aerobactin Synthetase IucA from a Hypervirulent Pathotype of Klebsiella pneumoniae"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC4928626/""}, {""id"": ""PMID:29618511"", ""source_sha256"": ""c77b02de555a96e8cce88e3d6000a3231d8a1f0e5a9efdbc7fd753637109256c"", ""source_version"": ""Original research article; retained PMC HTML retrieved 2026-10-11"", ""title"": ""Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC5961048/""}, {""id"": ""PMID:32432457"", ""source_sha256"": ""7d763303a9ceb74a944a9708db8314c8f0e347cf8b70bef7e2679a0f72f300cb"", ""source_version"": ""Original research article; retained PMC HTML retrieved 2026-10-11"", ""title"": ""The Siderophore Synthetase IucA of the Aerobactin Biosynthetic Pathway Uses an Ordered Mechanism"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC7325057/""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-028_1fd7b7742454	NCBIProtein:EMB09146.1	pathwaymech:enables	RHEA:32168	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:EMB09146.1|PMID:29618511	The hvKP1 IucC gene product enables the second ligation. Wild-type solution studies detected tetramer and dimer populations with an ATP-associated shift toward dimer; the crystal structure used a surface mutant. This role does not assert monomer sufficiency or a fixed assembly under all conditions.	"[{""reference_id"": ""NCBIProtein:EMB09146.1"", ""source_assertion"": ""The original GenPept entry EMB09146.1 identifies the hvKP1 gene product and its native protein sequence; function is supplied by the separately cited primary experiments."", ""source_locator"": ""GBSeq[GBSeq_accession-version='EMB09146.1']/GBSeq_source; GBSeq_feature-table/GBFeature[GBFeature_key='CDS']; GBSeq_sequence""}, {""reference_id"": ""PMID:29618511"", ""source_assertion"": ""IucC converted the IucA-produced citryl-ahLys intermediate to aerobactin; it did not replace the first IucA ligation."", ""source_locator"": ""PMC5961048 Figure 1; Results/sec4 (In vitro aerobactin reconstitution), Figure 3; Discussion/sec10/p[2]; Experimental procedures/sec12/p[1]""}, {""reference_id"": ""PMID:29618511"", ""source_assertion"": ""Wild-type IucC occupies tetramer and dimer populations, with ATP-associated conditions favoring dimer; the crystal structure used a surface mutant."", ""source_locator"": ""PMC5961048 Results/sec8 (X-ray crystal structure of IucC), sec9 (Quaternary structure), Figure 7""}]"	"[{""id"": ""NCBIProtein:EMB09146.1"", ""source_sha256"": ""b0d21b01a6cd2e85625bd1713fafd2def712e80db63f7fefea5d17049c21776b"", ""source_version"": ""NCBI GenPept original four-record batch retrieved 2026-10-11; hash covers complete batch; entries updated 2013-02-07"", ""title"": ""IucC [Klebsiella pneumoniae hvKP1]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=EMB09144.1,EMB09145.1,EMB09146.1,EMB09147.1&retmode=xml""}, {""id"": ""PMID:29618511"", ""source_sha256"": ""c77b02de555a96e8cce88e3d6000a3231d8a1f0e5a9efdbc7fd753637109256c"", ""source_version"": ""Original research article; retained PMC HTML retrieved 2026-10-11"", ""title"": ""Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC5961048/""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-029_0e7e3df2694d	RHEA:23229	BFO:0000050	GO:0019270	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0019270|MetaCyc:1.14.13.59-RXN|MetaCyc:AEROBACTINSYN-PWY|RHEA:23229		"[{""reference_id"": ""GO:0019270"", ""source_assertion"": ""GO:0019270 denotes aerobactin biosynthesis, the complete formation of the hydroxamate siderophore."", ""source_locator"": ""results[0]/id; name; definition/text""}, {""reference_id"": ""MetaCyc:AEROBACTINSYN-PWY"", ""source_assertion"": ""AEROBACTINSYN-PWY explicitly includes 1.14.13.59-RXN among its four reactions; its layout selects L2R. "", ""source_locator"": ""Pathway[@frameid=\""AEROBACTINSYN-PWY\""]/reaction-list; reaction-layout[Reaction/@frameid=\""1.14.13.59-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:1.14.13.59-RXN"", ""source_assertion"": ""The native reaction has the explicit RHEA unification cross-reference 23229, preserving the selected forward reaction identity."", ""source_locator"": ""Reaction/dblink[dblink-db=\""RHEA\""]/dblink-oid; dblink-relationship""}, {""reference_id"": ""RHEA:23229"", ""source_assertion"": ""Master RHEA:23228 links the selected directed reaction RHEA:23229, whose substrate and product sides specify forward synthesis."", ""source_locator"": ""http://rdf.rhea-db.org/23228 rh:directionalReaction http://rdf.rhea-db.org/23229; http://rdf.rhea-db.org/23229 rh:substrates/rh:products""}]"	"[{""id"": ""GO:0019270"", ""source_sha256"": ""7c17433871618734211ebf40f3688e4d7ce672edce32bdae9552649b810678e1"", ""source_version"": ""QuickGO original JSON retrieved 2026-10-11"", ""title"": ""Gene Ontology: aerobactin biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:0019270""}, {""id"": ""MetaCyc:1.14.13.59-RXN"", ""source_sha256"": ""391ee0de591b25c9233a4fa4d9ab65f6cb39c6de58cfc0e09462291c392f35c1"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native reaction 1.14.13.59-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:1.14.13.59-RXN""}, {""id"": ""MetaCyc:AEROBACTINSYN-PWY"", ""source_sha256"": ""077a58019ad4884c170aeda858cbf7eeb08de49e5cf39729d3aab0a08b931a2a"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc aerobactin biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:AEROBACTINSYN-PWY""}, {""id"": ""RHEA:23229"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 23229"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-030_f3607c8eaac9	RHEA:22389	BFO:0000050	GO:0019270	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0019270|MetaCyc:AEROBACTINSYN-PWY|MetaCyc:N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN|RHEA:22389		"[{""reference_id"": ""GO:0019270"", ""source_assertion"": ""GO:0019270 denotes aerobactin biosynthesis, the complete formation of the hydroxamate siderophore."", ""source_locator"": ""results[0]/id; name; definition/text""}, {""reference_id"": ""MetaCyc:AEROBACTINSYN-PWY"", ""source_assertion"": ""AEROBACTINSYN-PWY explicitly includes N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN among its four reactions; its layout selects L2R. "", ""source_locator"": ""Pathway[@frameid=\""AEROBACTINSYN-PWY\""]/reaction-list; reaction-layout[Reaction/@frameid=\""N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN"", ""source_assertion"": ""The native reaction has the explicit RHEA unification cross-reference 22389, preserving the selected forward reaction identity."", ""source_locator"": ""Reaction/dblink[dblink-db=\""RHEA\""]/dblink-oid; dblink-relationship""}, {""reference_id"": ""RHEA:22389"", ""source_assertion"": ""Master RHEA:22388 links the selected directed reaction RHEA:22389, whose substrate and product sides specify forward synthesis."", ""source_locator"": ""http://rdf.rhea-db.org/22388 rh:directionalReaction http://rdf.rhea-db.org/22389; http://rdf.rhea-db.org/22389 rh:substrates/rh:products""}]"	"[{""id"": ""GO:0019270"", ""source_sha256"": ""7c17433871618734211ebf40f3688e4d7ce672edce32bdae9552649b810678e1"", ""source_version"": ""QuickGO original JSON retrieved 2026-10-11"", ""title"": ""Gene Ontology: aerobactin biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:0019270""}, {""id"": ""MetaCyc:AEROBACTINSYN-PWY"", ""source_sha256"": ""077a58019ad4884c170aeda858cbf7eeb08de49e5cf39729d3aab0a08b931a2a"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc aerobactin biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:AEROBACTINSYN-PWY""}, {""id"": ""MetaCyc:N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN"", ""source_sha256"": ""b1a7c8592b592f483fbd6ca1694be7ad982d30313c253f0a05c8c6fc82f3b7b5"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native reaction N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN""}, {""id"": ""RHEA:22389"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 22389"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-031_9400b6d0a72c	RHEA:32164	BFO:0000050	GO:0019270	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0019270|MetaCyc:AEROBACTINSYN-PWY|MetaCyc:RXN-13054|RHEA:32164		"[{""reference_id"": ""GO:0019270"", ""source_assertion"": ""GO:0019270 denotes aerobactin biosynthesis, the complete formation of the hydroxamate siderophore."", ""source_locator"": ""results[0]/id; name; definition/text""}, {""reference_id"": ""MetaCyc:AEROBACTINSYN-PWY"", ""source_assertion"": ""AEROBACTINSYN-PWY explicitly includes RXN-13054 among its four reactions; its layout selects L2R. "", ""source_locator"": ""Pathway[@frameid=\""AEROBACTINSYN-PWY\""]/reaction-list; reaction-layout[Reaction/@frameid=\""RXN-13054\""]/direction""}, {""reference_id"": ""MetaCyc:RXN-13054"", ""source_assertion"": ""The native reaction has the explicit RHEA unification cross-reference 32164, preserving the selected forward reaction identity."", ""source_locator"": ""Reaction/dblink[dblink-db=\""RHEA\""]/dblink-oid; dblink-relationship""}, {""reference_id"": ""RHEA:32164"", ""source_assertion"": ""Master RHEA:32163 links the selected directed reaction RHEA:32164, whose substrate and product sides specify forward synthesis."", ""source_locator"": ""http://rdf.rhea-db.org/32163 rh:directionalReaction http://rdf.rhea-db.org/32164; http://rdf.rhea-db.org/32164 rh:substrates/rh:products""}]"	"[{""id"": ""GO:0019270"", ""source_sha256"": ""7c17433871618734211ebf40f3688e4d7ce672edce32bdae9552649b810678e1"", ""source_version"": ""QuickGO original JSON retrieved 2026-10-11"", ""title"": ""Gene Ontology: aerobactin biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:0019270""}, {""id"": ""MetaCyc:AEROBACTINSYN-PWY"", ""source_sha256"": ""077a58019ad4884c170aeda858cbf7eeb08de49e5cf39729d3aab0a08b931a2a"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc aerobactin biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:AEROBACTINSYN-PWY""}, {""id"": ""MetaCyc:RXN-13054"", ""source_sha256"": ""d8f700ae72a67048f290dddecd0ede20aef5eaa47253938f77a81115d55aa263"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native reaction RXN-13054"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-13054""}, {""id"": ""RHEA:32164"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32164"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-032_12bfbccdeeeb	RHEA:32168	BFO:0000050	GO:0019270	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0019270|MetaCyc:AEROBACTINSYN-PWY|MetaCyc:RXN-13056|RHEA:32168		"[{""reference_id"": ""GO:0019270"", ""source_assertion"": ""GO:0019270 denotes aerobactin biosynthesis, the complete formation of the hydroxamate siderophore."", ""source_locator"": ""results[0]/id; name; definition/text""}, {""reference_id"": ""MetaCyc:AEROBACTINSYN-PWY"", ""source_assertion"": ""AEROBACTINSYN-PWY explicitly includes RXN-13056 among its four reactions; its layout selects L2R. "", ""source_locator"": ""Pathway[@frameid=\""AEROBACTINSYN-PWY\""]/reaction-list; reaction-layout[Reaction/@frameid=\""RXN-13056\""]/direction""}, {""reference_id"": ""MetaCyc:RXN-13056"", ""source_assertion"": ""The native reaction has the explicit RHEA unification cross-reference 32168, preserving the selected forward reaction identity."", ""source_locator"": ""Reaction/dblink[dblink-db=\""RHEA\""]/dblink-oid; dblink-relationship""}, {""reference_id"": ""RHEA:32168"", ""source_assertion"": ""Master RHEA:32167 links the selected directed reaction RHEA:32168, whose substrate and product sides specify forward synthesis."", ""source_locator"": ""http://rdf.rhea-db.org/32167 rh:directionalReaction http://rdf.rhea-db.org/32168; http://rdf.rhea-db.org/32168 rh:substrates/rh:products""}]"	"[{""id"": ""GO:0019270"", ""source_sha256"": ""7c17433871618734211ebf40f3688e4d7ce672edce32bdae9552649b810678e1"", ""source_version"": ""QuickGO original JSON retrieved 2026-10-11"", ""title"": ""Gene Ontology: aerobactin biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:0019270""}, {""id"": ""MetaCyc:AEROBACTINSYN-PWY"", ""source_sha256"": ""077a58019ad4884c170aeda858cbf7eeb08de49e5cf39729d3aab0a08b931a2a"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc aerobactin biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:AEROBACTINSYN-PWY""}, {""id"": ""MetaCyc:RXN-13056"", ""source_sha256"": ""af35ca30a54e5d2f0e69f9c757a51aa3a00bcd11c4beb7046bad84fd93589d50"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native reaction RXN-13056"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-13056""}, {""id"": ""RHEA:32168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32168"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-033_d970bc9ea452	RHEA:23229	RO:0002413	RHEA:22389	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:AEROBACTINSYN-PWY|RHEA:22389|RHEA:23229	The source products and substrates independently identify the shared chemical intermediate.	"[{""reference_id"": ""MetaCyc:AEROBACTINSYN-PWY"", ""source_assertion"": ""The native reaction-ordering places 1.14.13.59-RXN before N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN."", ""source_locator"": ""Pathway[@frameid=\""AEROBACTINSYN-PWY\""]/reaction-ordering""}, {""reference_id"": ""RHEA:23229"", ""source_assertion"": ""RHEA:23229 assigns CHEBI:57820 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23229 rh:products http://rdf.rhea-db.org/23228_R; http://rdf.rhea-db.org/23228_R rh:contains1 http://rdf.rhea-db.org/Participant_23228_compound_2821; rh:compound http://rdf.rhea-db.org/Compound_2821; rh:chebi""}, {""reference_id"": ""RHEA:22389"", ""source_assertion"": ""RHEA:22389 assigns CHEBI:57820 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22389 rh:substrates http://rdf.rhea-db.org/22388_L; http://rdf.rhea-db.org/22388_L rh:contains1 http://rdf.rhea-db.org/Participant_22388_compound_2821; rh:compound http://rdf.rhea-db.org/Compound_2821; rh:chebi""}]"	"[{""id"": ""MetaCyc:AEROBACTINSYN-PWY"", ""source_sha256"": ""077a58019ad4884c170aeda858cbf7eeb08de49e5cf39729d3aab0a08b931a2a"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc aerobactin biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:AEROBACTINSYN-PWY""}, {""id"": ""RHEA:22389"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 22389"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:23229"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 23229"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-034_96c59964f5cc	RHEA:22389	RO:0002413	RHEA:32164	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:AEROBACTINSYN-PWY|RHEA:22389|RHEA:32164	The source products and substrates independently identify the shared chemical intermediate.	"[{""reference_id"": ""MetaCyc:AEROBACTINSYN-PWY"", ""source_assertion"": ""The native reaction-ordering places N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN before RXN-13054."", ""source_locator"": ""Pathway[@frameid=\""AEROBACTINSYN-PWY\""]/reaction-ordering""}, {""reference_id"": ""RHEA:22389"", ""source_assertion"": ""RHEA:22389 assigns CHEBI:58122 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22389 rh:products http://rdf.rhea-db.org/22388_R; http://rdf.rhea-db.org/22388_R rh:contains1 http://rdf.rhea-db.org/Participant_22388_compound_4878; rh:compound http://rdf.rhea-db.org/Compound_4878; rh:chebi""}, {""reference_id"": ""RHEA:32164"", ""source_assertion"": ""RHEA:32164 assigns CHEBI:58122 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/32164 rh:substrates http://rdf.rhea-db.org/32163_L; http://rdf.rhea-db.org/32163_L rh:contains1 http://rdf.rhea-db.org/Participant_32163_compound_4878; rh:compound http://rdf.rhea-db.org/Compound_4878; rh:chebi""}]"	"[{""id"": ""MetaCyc:AEROBACTINSYN-PWY"", ""source_sha256"": ""077a58019ad4884c170aeda858cbf7eeb08de49e5cf39729d3aab0a08b931a2a"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc aerobactin biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:AEROBACTINSYN-PWY""}, {""id"": ""RHEA:22389"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 22389"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:32164"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32164"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-035_e4e13bb67a67	RHEA:32164	RO:0002413	RHEA:32168	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:AEROBACTINSYN-PWY|RHEA:32164|RHEA:32168	CHEBI:63796 is the issued lysine-S class with unspecified citrate-derived stereocenter. The hvKP1 experiments select its 3S,2′S member; this graph does not assert acceptance of the 3R member or an exact stereochemical identity between the class and that measured product.	"[{""reference_id"": ""MetaCyc:AEROBACTINSYN-PWY"", ""source_assertion"": ""The native reaction-ordering places RXN-13054 before RXN-13056."", ""source_locator"": ""Pathway[@frameid=\""AEROBACTINSYN-PWY\""]/reaction-ordering""}, {""reference_id"": ""RHEA:32164"", ""source_assertion"": ""RHEA:32164 assigns CHEBI:63796 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/32164 rh:products http://rdf.rhea-db.org/32163_R; http://rdf.rhea-db.org/32163_R rh:contains1 http://rdf.rhea-db.org/Participant_32163_compound_7047; rh:compound http://rdf.rhea-db.org/Compound_7047; rh:chebi""}, {""reference_id"": ""RHEA:32168"", ""source_assertion"": ""RHEA:32168 assigns CHEBI:63796 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/32168 rh:substrates http://rdf.rhea-db.org/32167_L; http://rdf.rhea-db.org/32167_L rh:contains1 http://rdf.rhea-db.org/Participant_32167_compound_7047; rh:compound http://rdf.rhea-db.org/Compound_7047; rh:chebi""}]"	"[{""id"": ""MetaCyc:AEROBACTINSYN-PWY"", ""source_sha256"": ""077a58019ad4884c170aeda858cbf7eeb08de49e5cf39729d3aab0a08b931a2a"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc aerobactin biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:AEROBACTINSYN-PWY""}, {""id"": ""RHEA:32164"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32164"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:32168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32168"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-036_fa34ab019e5c	RHEA:22389	RO:0002413	RHEA:32168	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22389|RHEA:32168	A second equivalent of the IucB-produced building block supplies IucC; the first two transformations operate twice per aerobactin molecule.	"[{""reference_id"": ""RHEA:22389"", ""source_assertion"": ""RHEA:22389 assigns CHEBI:58122 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22389 rh:products http://rdf.rhea-db.org/22388_R; http://rdf.rhea-db.org/22388_R rh:contains1 http://rdf.rhea-db.org/Participant_22388_compound_4878; rh:compound http://rdf.rhea-db.org/Compound_4878; rh:chebi""}, {""reference_id"": ""RHEA:32168"", ""source_assertion"": ""RHEA:32168 assigns CHEBI:58122 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/32168 rh:substrates http://rdf.rhea-db.org/32167_L; http://rdf.rhea-db.org/32167_L rh:contains1 http://rdf.rhea-db.org/Participant_32167_compound_4878; rh:compound http://rdf.rhea-db.org/Compound_4878; rh:chebi""}]"	"[{""id"": ""RHEA:22389"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 22389"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:32168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 32168"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-037_0c98617fa3a0	NCBIProtein:EMB09144.1	BFO:0000050	NCBITaxon:1267897	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:EMB09144.1		"[{""reference_id"": ""NCBIProtein:EMB09144.1"", ""source_assertion"": ""The native source feature identifies Klebsiella pneumoniae hvKP1, strain hvKP1 and taxon:1267897."", ""source_locator"": ""GBSeq[GBSeq_accession-version='EMB09144.1']/GBSeq_feature-table/GBFeature[GBFeature_key='source']/GBFeature_quals""}]"	"[{""id"": ""NCBIProtein:EMB09144.1"", ""source_sha256"": ""b0d21b01a6cd2e85625bd1713fafd2def712e80db63f7fefea5d17049c21776b"", ""source_version"": ""NCBI GenPept original four-record batch retrieved 2026-10-11; hash covers complete batch; entries updated 2013-02-07"", ""title"": ""hypothetical protein G057_19877 [Klebsiella pneumoniae hvKP1]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=EMB09144.1,EMB09145.1,EMB09146.1,EMB09147.1&retmode=xml""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-038_08fcc11c1197	NCBIProtein:EMB09145.1	BFO:0000050	NCBITaxon:1267897	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:EMB09145.1		"[{""reference_id"": ""NCBIProtein:EMB09145.1"", ""source_assertion"": ""The native source feature identifies Klebsiella pneumoniae hvKP1, strain hvKP1 and taxon:1267897."", ""source_locator"": ""GBSeq[GBSeq_accession-version='EMB09145.1']/GBSeq_feature-table/GBFeature[GBFeature_key='source']/GBFeature_quals""}]"	"[{""id"": ""NCBIProtein:EMB09145.1"", ""source_sha256"": ""b0d21b01a6cd2e85625bd1713fafd2def712e80db63f7fefea5d17049c21776b"", ""source_version"": ""NCBI GenPept original four-record batch retrieved 2026-10-11; hash covers complete batch; entries updated 2013-02-07"", ""title"": ""IucB [Klebsiella pneumoniae hvKP1]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=EMB09144.1,EMB09145.1,EMB09146.1,EMB09147.1&retmode=xml""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-039_987eaad206fb	NCBIProtein:EMB09146.1	BFO:0000050	NCBITaxon:1267897	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:EMB09146.1		"[{""reference_id"": ""NCBIProtein:EMB09146.1"", ""source_assertion"": ""The native source feature identifies Klebsiella pneumoniae hvKP1, strain hvKP1 and taxon:1267897."", ""source_locator"": ""GBSeq[GBSeq_accession-version='EMB09146.1']/GBSeq_feature-table/GBFeature[GBFeature_key='source']/GBFeature_quals""}]"	"[{""id"": ""NCBIProtein:EMB09146.1"", ""source_sha256"": ""b0d21b01a6cd2e85625bd1713fafd2def712e80db63f7fefea5d17049c21776b"", ""source_version"": ""NCBI GenPept original four-record batch retrieved 2026-10-11; hash covers complete batch; entries updated 2013-02-07"", ""title"": ""IucC [Klebsiella pneumoniae hvKP1]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=EMB09144.1,EMB09145.1,EMB09146.1,EMB09147.1&retmode=xml""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-040_c0e1c156845d	NCBIProtein:EMB09147.1	BFO:0000050	NCBITaxon:1267897	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:EMB09147.1		"[{""reference_id"": ""NCBIProtein:EMB09147.1"", ""source_assertion"": ""The native source feature identifies Klebsiella pneumoniae hvKP1, strain hvKP1 and taxon:1267897."", ""source_locator"": ""GBSeq[GBSeq_accession-version='EMB09147.1']/GBSeq_feature-table/GBFeature[GBFeature_key='source']/GBFeature_quals""}]"	"[{""id"": ""NCBIProtein:EMB09147.1"", ""source_sha256"": ""b0d21b01a6cd2e85625bd1713fafd2def712e80db63f7fefea5d17049c21776b"", ""source_version"": ""NCBI GenPept original four-record batch retrieved 2026-10-11; hash covers complete batch; entries updated 2013-02-07"", ""title"": ""IucD [Klebsiella pneumoniae hvKP1]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=EMB09144.1,EMB09145.1,EMB09146.1,EMB09147.1&retmode=xml""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-041_fa4fc69ef726	NCBIProtein:EMB09147.1	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:29618511	FAD is the enzyme cofactor, distinct from consumed NADPH. This statement retains the diagram and reconstitution scope; it does not import the E. coli soluble-construct tetramer.	"[{""reference_id"": ""PMID:29618511"", ""source_assertion"": ""Figure 1 depicts FAD with IucD lysine hydroxylation; the reconstituted hvKP1 pathway used FAD as cofactor."", ""source_locator"": ""PMC5961048 Figure 1; Results/sec4 (In vitro aerobactin reconstitution); original PDF pp.7842-7843""}]"	"[{""id"": ""PMID:29618511"", ""source_sha256"": ""c77b02de555a96e8cce88e3d6000a3231d8a1f0e5a9efdbc7fd753637109256c"", ""source_version"": ""Original research article; retained PMC HTML retrieved 2026-10-11"", ""title"": ""Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC5961048/""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-042_39d5f627b4a7	NCBIProtein:EMB09144.1	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:27253399	Supported Mg2+ association in the ATP-bound enzyme, rather than an obligatory free-metal requirement inferred only from assay MgATP. IucC metal placement in 2018 was modeled from IucA and is not a separate direct IucC cofactor assertion.	"[{""reference_id"": ""PMID:27253399"", ""source_assertion"": ""The ATP-bound hvKP1 IucA structure contains Mg2+ coordinated by ATP and enzyme side chains, providing direct active-site metal-binding evidence."", ""source_locator"": ""PMC4928626 Results/sec3.2/p[1] (Active Site), Figure 2A""}]"	"[{""id"": ""PMID:27253399"", ""source_sha256"": ""2084bc473dde1a33306f2f0b0c1cfc55d7d061bafd3ba3bdfac6b80619586db8"", ""source_version"": ""Original research article; retained PMC HTML retrieved 2026-10-11"", ""title"": ""Structural and Functional Characterization of Aerobactin Synthetase IucA from a Hypervirulent Pathotype of Klebsiella pneumoniae"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC4928626/""}]"	""
pathwaymech:GO_0019270_aerobactin-edge-043_0b7d330bdf24	GO:0019270	BFO:0000050	NCBITaxon:1267897	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBITaxon:1267897|PMID:29618511		"[{""reference_id"": ""PMID:29618511"", ""source_assertion"": ""All four iucA-D genes were obtained from the hvKP1 clinical isolate; purified preparations reconstituted the full pathway. E. coli was the heterologous expression host."", ""source_locator"": ""PMC5961048 Experimental procedures/sec12/p[1]; Results/sec4 and Figure 3""}, {""reference_id"": ""NCBITaxon:1267897"", ""source_assertion"": ""NCBI Taxonomy independently identifies taxon1267897 as Klebsiella pneumoniae hvKP1."", ""source_locator"": ""TaxaSet/Taxon/TaxId; ScientificName""}]"	"[{""id"": ""NCBITaxon:1267897"", ""source_sha256"": ""3daff0230c3c341165bba0009111bf77aeec707b8f7b3af005e6324b8b3a15d0"", ""source_version"": ""NCBI Taxonomy original XML retrieved 2026-10-11"", ""title"": ""NCBI Taxonomy: Klebsiella pneumoniae hvKP1"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=taxonomy&id=1267897&retmode=xml""}, {""id"": ""PMID:29618511"", ""source_sha256"": ""c77b02de555a96e8cce88e3d6000a3231d8a1f0e5a9efdbc7fd753637109256c"", ""source_version"": ""Original research article; retained PMC HTML retrieved 2026-10-11"", ""title"": ""Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC5961048/""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_edge-001_9d31f052af30	gomodel:GLYCEROL-KIN-RXN	RO:0002234	CHEBI:57597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-KIN-RXN RO:0002234 gomodel:CHEBI_57597_GLYCEROL-KIN-RXN."", ""source_locator"": ""./YeastPathways_AERO-GLYCEROL-CAT-PWY.json#/facts/0; endpoint types: /individuals/8/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_AERO-GLYCEROL-CAT-PWY.json"", ""title"": ""GO-CAM aerobic glycerol degradation model YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_edge-002_37035673a9de	SGD:S000001417	pathwaymech:enables	gomodel:RXN3O-9815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9815 RO:0002333 gomodel:YIL155C-MONOMER_RXN3O-9815_controller."", ""source_locator"": ""./YeastPathways_AERO-GLYCEROL-CAT-PWY.json#/facts/1; endpoint types: /individuals/9/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_AERO-GLYCEROL-CAT-PWY.json"", ""title"": ""GO-CAM aerobic glycerol degradation model YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_edge-003_12c473ef7343	gomodel:RXN3O-9815	RO:0002233	CHEBI:52971	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9815 RO:0002233 gomodel:CHEBI_52971_RXN3O-9815."", ""source_locator"": ""./YeastPathways_AERO-GLYCEROL-CAT-PWY.json#/facts/2; endpoint types: /individuals/9/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_AERO-GLYCEROL-CAT-PWY.json"", ""title"": ""GO-CAM aerobic glycerol degradation model YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_edge-004_1b7e156291d1	gomodel:GLYCEROL-KIN-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-KIN-RXN RO:0002234 gomodel:CHEBI_456216_GLYCEROL-KIN-RXN."", ""source_locator"": ""./YeastPathways_AERO-GLYCEROL-CAT-PWY.json#/facts/3; endpoint types: /individuals/8/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_AERO-GLYCEROL-CAT-PWY.json"", ""title"": ""GO-CAM aerobic glycerol degradation model YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_edge-005_72bfe525580d	gomodel:RXN3O-9815	BFO:0000066	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9815 BFO:0000066 gomodel:reaction_RXN3O-9815_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_AERO-GLYCEROL-CAT-PWY.json#/facts/4; endpoint types: /individuals/9/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_AERO-GLYCEROL-CAT-PWY.json"", ""title"": ""GO-CAM aerobic glycerol degradation model YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_edge-006_526cd804ce80	gomodel:RXN3O-9815	RO:0002234	CHEBI:52970	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9815 RO:0002234 gomodel:CHEBI_52970_RXN3O-9815."", ""source_locator"": ""./YeastPathways_AERO-GLYCEROL-CAT-PWY.json#/facts/5; endpoint types: /individuals/9/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_AERO-GLYCEROL-CAT-PWY.json"", ""title"": ""GO-CAM aerobic glycerol degradation model YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_edge-007_3d506c72278a	gomodel:GLYCEROL-KIN-RXN	RO:0002233	CHEBI:17754	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-KIN-RXN RO:0002233 gomodel:CHEBI_17754_GLYCEROL-KIN-RXN."", ""source_locator"": ""./YeastPathways_AERO-GLYCEROL-CAT-PWY.json#/facts/6; endpoint types: /individuals/8/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_AERO-GLYCEROL-CAT-PWY.json"", ""title"": ""GO-CAM aerobic glycerol degradation model YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_edge-008_267a7a0806aa	SGD:S000001024	pathwaymech:enables	gomodel:GLYCEROL-KIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-KIN-RXN RO:0002333 gomodel:YHL032C-MONOMER_GLYCEROL-KIN-RXN_controller."", ""source_locator"": ""./YeastPathways_AERO-GLYCEROL-CAT-PWY.json#/facts/7; endpoint types: /individuals/8/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_AERO-GLYCEROL-CAT-PWY.json"", ""title"": ""GO-CAM aerobic glycerol degradation model YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_edge-009_09aca3ddd133	gomodel:GLYCEROL-KIN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-KIN-RXN RO:0002233 gomodel:CHEBI_30616_GLYCEROL-KIN-RXN."", ""source_locator"": ""./YeastPathways_AERO-GLYCEROL-CAT-PWY.json#/facts/8; endpoint types: /individuals/8/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_AERO-GLYCEROL-CAT-PWY.json"", ""title"": ""GO-CAM aerobic glycerol degradation model YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_edge-010_45ccab002d80	gomodel:GLYCEROL-KIN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-KIN-RXN BFO:0000066 gomodel:reaction_GLYCEROL-KIN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_AERO-GLYCEROL-CAT-PWY.json#/facts/9; endpoint types: /individuals/8/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_AERO-GLYCEROL-CAT-PWY.json"", ""title"": ""GO-CAM aerobic glycerol degradation model YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_edge-011_fea18c77e9b9	gomodel:RXN3O-9815	BFO:0000050	GO:0019563	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9815 BFO:0000050 gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY/YeastPathways_AERO-GLYCEROL-CAT-PWY."", ""source_locator"": ""./YeastPathways_AERO-GLYCEROL-CAT-PWY.json#/facts/10; endpoint types: /individuals/9/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_AERO-GLYCEROL-CAT-PWY.json"", ""title"": ""GO-CAM aerobic glycerol degradation model YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_edge-012_8259419f8d40	gomodel:GLYCEROL-KIN-RXN	RO:0002413	gomodel:RXN3O-9815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-KIN-RXN RO:0002413 gomodel:RXN3O-9815."", ""source_locator"": ""./YeastPathways_AERO-GLYCEROL-CAT-PWY.json#/facts/11; endpoint types: /individuals/8/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_AERO-GLYCEROL-CAT-PWY.json"", ""title"": ""GO-CAM aerobic glycerol degradation model YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_edge-013_43b853f8c2e9	gomodel:GLYCEROL-KIN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-KIN-RXN RO:0002234 gomodel:CHEBI_15378_GLYCEROL-KIN-RXN."", ""source_locator"": ""./YeastPathways_AERO-GLYCEROL-CAT-PWY.json#/facts/12; endpoint types: /individuals/8/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_AERO-GLYCEROL-CAT-PWY.json"", ""title"": ""GO-CAM aerobic glycerol degradation model YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_edge-014_4fae8c179cc9	gomodel:RXN3O-9815	RO:0002233	CHEBI:57597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9815 RO:0002233 gomodel:CHEBI_57597_GLYCEROL-KIN-RXN."", ""source_locator"": ""./YeastPathways_AERO-GLYCEROL-CAT-PWY.json#/facts/13; endpoint types: /individuals/9/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_AERO-GLYCEROL-CAT-PWY.json"", ""title"": ""GO-CAM aerobic glycerol degradation model YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_edge-015_d3a61874b817	gomodel:GLYCEROL-KIN-RXN	BFO:0000050	GO:0019563	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-KIN-RXN BFO:0000050 gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY/YeastPathways_AERO-GLYCEROL-CAT-PWY."", ""source_locator"": ""./YeastPathways_AERO-GLYCEROL-CAT-PWY.json#/facts/14; endpoint types: /individuals/8/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_AERO-GLYCEROL-CAT-PWY.json"", ""title"": ""GO-CAM aerobic glycerol degradation model YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_edge-016_bbb5cf59bfbd	gomodel:RXN3O-9815	RO:0002234	CHEBI:57642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9815 RO:0002234 gomodel:CHEBI_57642_RXN3O-9815."", ""source_locator"": ""./YeastPathways_AERO-GLYCEROL-CAT-PWY.json#/facts/15; endpoint types: /individuals/9/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_AERO-GLYCEROL-CAT-PWY.json"", ""title"": ""GO-CAM aerobic glycerol degradation model YeastPathways_AERO-GLYCEROL-CAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_location-8705110042e5_c059f7ac6f63	SGD:S000001417	RO:0001025	GO:0005743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32191	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11502169)	"[{""reference_id"": ""UniProtKB:P32191"", ""source_assertion"": ""UniProtKB:P32191 annotates location Mitochondrion inner membrane (SL-0168)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3406/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32191"", ""source_assertion"": ""UniProtKB:P32191 has the exact SGD cross-reference SGD:S000001417."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3406/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32191"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32191 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_location-104ce7cd25b2_8c5dcaa5cfac	SGD:S000001417	RO:0001025	GO:0005758	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32191	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:22984289)	"[{""reference_id"": ""UniProtKB:P32191"", ""source_assertion"": ""UniProtKB:P32191 annotates location Mitochondrion intermembrane space (SL-0169)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3406/comments/0/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32191"", ""source_assertion"": ""UniProtKB:P32191 has the exact SGD cross-reference SGD:S000001417."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3406/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32191"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32191 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_AERO-GLYCEROL-CAT-PWY_cofactor-ceca8f2f8d21_f3db47fca273	SGD:S000001417	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32191	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P32191"", ""source_assertion"": ""UniProtKB:P32191 annotates CHEBI:57692 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3406/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P32191"", ""source_assertion"": ""UniProtKB:P32191 has the exact SGD cross-reference SGD:S000001417."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3406/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32191"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32191 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-001_662a8f692b74	CHEBI:15678	pathwaymech:consumes	RHEA:17030	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17029	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:17029"", ""source_assertion"": ""RHEA:17030 substrates contain CHEBI:15678 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17030 rh:substrates; http://rdf.rhea-db.org/17029_L rh:contains1 http://rdf.rhea-db.org/Participant_17029_compound_2545; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 17029 reaction family, selected direction 17030"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-002_d92cc037742a	CHEBI:15377	pathwaymech:consumes	RHEA:17030	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17029	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:17029"", ""source_assertion"": ""RHEA:17030 substrates contain CHEBI:15377 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17030 rh:substrates; http://rdf.rhea-db.org/17029_L rh:contains1 http://rdf.rhea-db.org/Participant_17029_compound_1283; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 17029 reaction family, selected direction 17030"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-003_913d1f031117	RHEA:17030	pathwaymech:produces	CHEBI:17536	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17029	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:17029"", ""source_assertion"": ""RHEA:17030 products contain CHEBI:17536 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17030 rh:products; http://rdf.rhea-db.org/17029_R rh:contains1 http://rdf.rhea-db.org/Participant_17029_compound_4604; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 17029 reaction family, selected direction 17030"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-004_93735fd331fc	RHEA:17030	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17029	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:17029"", ""source_assertion"": ""RHEA:17030 products contain CHEBI:15378 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17030 rh:products; http://rdf.rhea-db.org/17029_R rh:contains1 http://rdf.rhea-db.org/Participant_17029_compound_3249; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 17029 reaction family, selected direction 17030"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-005_166297ca45af	CHEBI:17536	pathwaymech:consumes	RHEA:27486	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27485	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:27485"", ""source_assertion"": ""RHEA:27486 substrates contain CHEBI:17536 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/27486 rh:substrates; http://rdf.rhea-db.org/27485_L rh:contains1 http://rdf.rhea-db.org/Participant_27485_compound_4604; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27485"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 27485 reaction family, selected direction 27486"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-006_c6c81d6e1fe6	CHEBI:15377	pathwaymech:consumes	RHEA:27486	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27485	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:27485"", ""source_assertion"": ""RHEA:27486 substrates contain CHEBI:15377 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/27486 rh:substrates; http://rdf.rhea-db.org/27485_L rh:contains1 http://rdf.rhea-db.org/Participant_27485_compound_1283; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27485"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 27485 reaction family, selected direction 27486"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-007_af3b82546300	CHEBI:15378	pathwaymech:consumes	RHEA:27486	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27485	Coefficient 2 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:27485"", ""source_assertion"": ""RHEA:27486 substrates contain CHEBI:15378 with coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/27486 rh:substrates; http://rdf.rhea-db.org/27485_L rh:contains2 http://rdf.rhea-db.org/Participant_27485_compound_3249; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27485"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 27485 reaction family, selected direction 27486"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-008_c4ec8efb8fb4	RHEA:27486	pathwaymech:produces	CHEBI:59947	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27485	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:27485"", ""source_assertion"": ""RHEA:27486 products contain CHEBI:59947 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/27486 rh:products; http://rdf.rhea-db.org/27485_R rh:contains1 http://rdf.rhea-db.org/Participant_27485_compound_6148; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27485"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 27485 reaction family, selected direction 27486"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-009_9ec3dde89e50	RHEA:27486	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27485	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:27485"", ""source_assertion"": ""RHEA:27486 products contain CHEBI:28938 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/27486 rh:products; http://rdf.rhea-db.org/27485_R rh:contains1 http://rdf.rhea-db.org/Participant_27485_compound_1012; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27485"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 27485 reaction family, selected direction 27486"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-010_437876bd57fa	RHEA:27486	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27485	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:27485"", ""source_assertion"": ""RHEA:27486 products contain CHEBI:16526 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/27486 rh:products; http://rdf.rhea-db.org/27485_R rh:contains1 http://rdf.rhea-db.org/Participant_27485_compound_4391; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27485"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 27485 reaction family, selected direction 27486"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-011_227cde9cc1b1	CHEBI:59947	pathwaymech:consumes	RHEA:25242	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25241	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:25241"", ""source_assertion"": ""RHEA:25242 substrates contain CHEBI:59947 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25242 rh:substrates; http://rdf.rhea-db.org/25241_L rh:contains1 http://rdf.rhea-db.org/Participant_25241_compound_6148; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25241"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 25241 reaction family, selected direction 25242"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-012_557e3de646ea	CHEBI:15377	pathwaymech:consumes	RHEA:25242	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25241	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:25241"", ""source_assertion"": ""RHEA:25242 substrates contain CHEBI:15377 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25242 rh:substrates; http://rdf.rhea-db.org/25241_L rh:contains1 http://rdf.rhea-db.org/Participant_25241_compound_1283; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25241"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 25241 reaction family, selected direction 25242"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-013_1b26a18332d1	RHEA:25242	pathwaymech:produces	CHEBI:57296	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25241	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:25241"", ""source_assertion"": ""RHEA:25242 products contain CHEBI:57296 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25242 rh:products; http://rdf.rhea-db.org/25241_R rh:contains1 http://rdf.rhea-db.org/Participant_25241_compound_4140; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25241"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 25241 reaction family, selected direction 25242"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-014_84de98abdd8a	RHEA:25242	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25241	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:25241"", ""source_assertion"": ""RHEA:25242 products contain CHEBI:28938 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25242 rh:products; http://rdf.rhea-db.org/25241_R rh:contains1 http://rdf.rhea-db.org/Participant_25241_compound_1012; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25241"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 25241 reaction family, selected direction 25242"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-015_2dd59cb86248	CHEBI:57296	pathwaymech:consumes	RHEA:15330	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15329	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:15329"", ""source_assertion"": ""RHEA:15330 substrates contain CHEBI:57296 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/15330 rh:substrates; http://rdf.rhea-db.org/15329_L rh:contains1 http://rdf.rhea-db.org/Participant_15329_compound_4140; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15329"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 15329 reaction family, selected direction 15330"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-016_31453a2d5b62	CHEBI:57540	pathwaymech:consumes	RHEA:15330	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15329	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:15329"", ""source_assertion"": ""RHEA:15330 substrates contain CHEBI:57540 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/15330 rh:substrates; http://rdf.rhea-db.org/15329_L rh:contains1 http://rdf.rhea-db.org/Participant_15329_compound_3484; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15329"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 15329 reaction family, selected direction 15330"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-017_ef714bd12971	RHEA:15330	pathwaymech:produces	CHEBI:57824	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15329	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:15329"", ""source_assertion"": ""RHEA:15330 products contain CHEBI:57824 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/15330 rh:products; http://rdf.rhea-db.org/15329_R rh:contains1 http://rdf.rhea-db.org/Participant_15329_compound_1605; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15329"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 15329 reaction family, selected direction 15330"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-018_955eb57bf0ab	RHEA:15330	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15329	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:15329"", ""source_assertion"": ""RHEA:15330 products contain CHEBI:57945 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/15330 rh:products; http://rdf.rhea-db.org/15329_R rh:contains1 http://rdf.rhea-db.org/Participant_15329_compound_1650; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15329"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 15329 reaction family, selected direction 15330"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-019_6bc1bfd44ed5	RHEA:15330	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15329	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:15329"", ""source_assertion"": ""RHEA:15330 products contain CHEBI:15378 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/15330 rh:products; http://rdf.rhea-db.org/15329_R rh:contains1 http://rdf.rhea-db.org/Participant_15329_compound_3249; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15329"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 15329 reaction family, selected direction 15330"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-020_f8671ca3160f	CHEBI:57824	pathwaymech:consumes	RHEA:22986	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22984	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:22984"", ""source_assertion"": ""RHEA:22986 substrates contain CHEBI:57824 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22986 rh:substrates; http://rdf.rhea-db.org/22984_R rh:contains1 http://rdf.rhea-db.org/Participant_22984_compound_1605; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22984"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 22984 reaction family, selected direction 22986"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-021_fe6165395eb6	CHEBI:43474	pathwaymech:consumes	RHEA:22986	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22984	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:22984"", ""source_assertion"": ""RHEA:22986 substrates contain CHEBI:43474 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22986 rh:substrates; http://rdf.rhea-db.org/22984_R rh:contains1 http://rdf.rhea-db.org/Participant_22984_compound_5518; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22984"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 22984 reaction family, selected direction 22986"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-022_bf20179745d2	RHEA:22986	pathwaymech:produces	CHEBI:58363	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22984	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:22984"", ""source_assertion"": ""RHEA:22986 products contain CHEBI:58363 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22986 rh:products; http://rdf.rhea-db.org/22984_L rh:contains1 http://rdf.rhea-db.org/Participant_22984_compound_1815; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22984"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 22984 reaction family, selected direction 22986"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-023_e5c3026bf888	RHEA:22986	pathwaymech:produces	CHEBI:58228	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22984	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:22984"", ""source_assertion"": ""RHEA:22986 products contain CHEBI:58228 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22986 rh:products; http://rdf.rhea-db.org/22984_L rh:contains1 http://rdf.rhea-db.org/Participant_22984_compound_4600; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22984"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 22984 reaction family, selected direction 22986"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-024_abb590670449	CHEBI:58228	pathwaymech:consumes	RHEA:30757	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30755	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:30755"", ""source_assertion"": ""RHEA:30757 substrates contain CHEBI:58228 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30757 rh:substrates; http://rdf.rhea-db.org/30755_R rh:contains1 http://rdf.rhea-db.org/Participant_30755_compound_4600; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:30755"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 30755 reaction family, selected direction 30757"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-025_7bec05429530	CHEBI:456216	pathwaymech:consumes	RHEA:30757	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30755	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:30755"", ""source_assertion"": ""RHEA:30757 substrates contain CHEBI:456216 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30757 rh:substrates; http://rdf.rhea-db.org/30755_R rh:contains1 http://rdf.rhea-db.org/Participant_30755_compound_2710; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:30755"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 30755 reaction family, selected direction 30757"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-026_82f5041e1351	RHEA:30757	pathwaymech:produces	CHEBI:13941	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30755	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:30755"", ""source_assertion"": ""RHEA:30757 products contain CHEBI:13941 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30757 rh:products; http://rdf.rhea-db.org/30755_L rh:contains1 http://rdf.rhea-db.org/Participant_30755_compound_4239; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:30755"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 30755 reaction family, selected direction 30757"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-027_7def6d99f4db	RHEA:30757	pathwaymech:produces	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30755	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:30755"", ""source_assertion"": ""RHEA:30757 products contain CHEBI:30616 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30757 rh:products; http://rdf.rhea-db.org/30755_L rh:contains1 http://rdf.rhea-db.org/Participant_30755_compound_6372; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:30755"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 30755 reaction family, selected direction 30757"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-028_60d89f5c0abd	CHEBI:13941	pathwaymech:consumes	RHEA:15650	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15649	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:15649"", ""source_assertion"": ""RHEA:15650 substrates contain CHEBI:13941 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/15650 rh:substrates; http://rdf.rhea-db.org/15649_L rh:contains1 http://rdf.rhea-db.org/Participant_15649_compound_4239; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15649"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 15649 reaction family, selected direction 15650"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-029_d5529164de73	CHEBI:15378	pathwaymech:consumes	RHEA:15650	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15649	Coefficient 2 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:15649"", ""source_assertion"": ""RHEA:15650 substrates contain CHEBI:15378 with coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/15650 rh:substrates; http://rdf.rhea-db.org/15649_L rh:contains2 http://rdf.rhea-db.org/Participant_15649_compound_3249; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15649"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 15649 reaction family, selected direction 15650"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-030_ae20ba4257f7	RHEA:15650	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15649	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:15649"", ""source_assertion"": ""RHEA:15650 products contain CHEBI:28938 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/15650 rh:products; http://rdf.rhea-db.org/15649_R rh:contains1 http://rdf.rhea-db.org/Participant_15649_compound_1012; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15649"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 15649 reaction family, selected direction 15650"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-031_388667e53b71	RHEA:15650	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15649	Coefficient 1 in the selected directed Rhea equation; formal stereochemistry and charge are retained.	"[{""reference_id"": ""RHEA:15649"", ""source_assertion"": ""RHEA:15650 products contain CHEBI:16526 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/15650 rh:products; http://rdf.rhea-db.org/15649_R rh:contains1 http://rdf.rhea-db.org/Participant_15649_compound_4391; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15649"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 15649 reaction family, selected direction 15650"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-032_c7a84e992722	RHEA:17030	BFO:0000050	MetaCyc:PWY0-41	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ALLANTOINASE-RXN|MetaCyc:PWY-5698|MetaCyc:PWY0-41|RHEA:17029	Native pathway reaction, with the directed current Rhea chemistry independently resolved.	"[{""reference_id"": ""MetaCyc:PWY0-41"", ""source_assertion"": ""PWY0-41 contains the ammonia-producing upstream subpathway PWY-5698."", ""source_locator"": ""Pathway[@frameid=\""PWY0-41\""]/sub-pathways; reaction-list""}, {""reference_id"": ""MetaCyc:PWY-5698"", ""source_assertion"": ""PWY-5698 includes native reaction ALLANTOINASE-RXN."", ""source_locator"": ""Pathway[@frameid=\""PWY-5698\""]/reaction-list""}, {""reference_id"": ""MetaCyc:ALLANTOINASE-RXN"", ""source_assertion"": ""The native reaction links to RHEA:17030; its participants agree with the selected physiological transformation."", ""source_locator"": ""Reaction/left; Reaction/right; Reaction/dblink""}, {""reference_id"": ""RHEA:17029"", ""source_assertion"": ""RHEA:17029 has directional reaction RHEA:17030."", ""source_locator"": ""http://rdf.rhea-db.org/17029 rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:ALLANTOINASE-RXN"", ""source_sha256"": ""ffde639061cf1091bc7e1b70dab1bc42217e3fb47dd85382e48a4581e802fdf2"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc ALLANTOINASE-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ALLANTOINASE-RXN""}, {""id"": ""MetaCyc:PWY-5698"", ""source_sha256"": ""a89a140f3dc86e1e05cc22c7cd90fed3cd3e20cfe15ad041961fa6a6c45a4071"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc PWY-5698"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5698""}, {""id"": ""MetaCyc:PWY0-41"", ""source_sha256"": ""c971c13063eaec46162a49000ceffb4c3d6fbfbc1e04ebf9f5ae4f3537065a93"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc PWY0-41"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-41""}, {""id"": ""RHEA:17029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 17029 reaction family, selected direction 17030"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-033_a480b7ee917e	RHEA:27486	BFO:0000050	MetaCyc:PWY0-41	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ALLANTOATE-DEIMINASE-RXN|MetaCyc:PWY-5698|MetaCyc:PWY0-41|RHEA:27485|UniProtKB:P77425	Native pathway reaction, with the directed current Rhea chemistry independently resolved. The obsolete native cross-reference is rejected rather than silently reused.	"[{""reference_id"": ""MetaCyc:PWY0-41"", ""source_assertion"": ""PWY0-41 contains the ammonia-producing upstream subpathway PWY-5698."", ""source_locator"": ""Pathway[@frameid=\""PWY0-41\""]/sub-pathways; reaction-list""}, {""reference_id"": ""MetaCyc:PWY-5698"", ""source_assertion"": ""PWY-5698 includes native reaction ALLANTOATE-DEIMINASE-RXN."", ""source_locator"": ""Pathway[@frameid=\""PWY-5698\""]/reaction-list""}, {""reference_id"": ""MetaCyc:ALLANTOATE-DEIMINASE-RXN"", ""source_assertion"": ""Native sides produce S-ureidoglycine, ammonium and carbon dioxide from allantoate; the old Rhea13594 link is not accepted as the current mapping."", ""source_locator"": ""Reaction/left; Reaction/right; Reaction/dblink""}, {""reference_id"": ""UniProtKB:P77425"", ""source_assertion"": ""Current AllC catalytic annotation identifies the ureidoglycine-producing reaction as RHEA:27485, supported by PMID:20038185. Evidence: ECO:0000269."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences; evidences""}, {""reference_id"": ""RHEA:27485"", ""source_assertion"": ""RHEA:27485 has directional reaction RHEA:27486."", ""source_locator"": ""http://rdf.rhea-db.org/27485 rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:ALLANTOATE-DEIMINASE-RXN"", ""source_sha256"": ""508bed1d9de239993214c5e6d32a3e73e4396aad76a0202d7e088eac35d10300"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc ALLANTOATE-DEIMINASE-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ALLANTOATE-DEIMINASE-RXN""}, {""id"": ""MetaCyc:PWY-5698"", ""source_sha256"": ""a89a140f3dc86e1e05cc22c7cd90fed3cd3e20cfe15ad041961fa6a6c45a4071"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc PWY-5698"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5698""}, {""id"": ""MetaCyc:PWY0-41"", ""source_sha256"": ""c971c13063eaec46162a49000ceffb4c3d6fbfbc1e04ebf9f5ae4f3537065a93"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc PWY0-41"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-41""}, {""id"": ""RHEA:27485"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 27485 reaction family, selected direction 27486"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P77425"", ""source_sha256"": ""880e9d42e786beb498bf8e2e71c59fb0e4c769e06423a5ba3d15594ee0827907"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P77425"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77425.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-034_5ab204ea8dc7	RHEA:25242	BFO:0000050	MetaCyc:PWY0-41	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5698|MetaCyc:PWY0-41|MetaCyc:URUR-RXN|RHEA:25241	Native pathway reaction, with the directed current Rhea chemistry independently resolved.	"[{""reference_id"": ""MetaCyc:PWY0-41"", ""source_assertion"": ""PWY0-41 contains the ammonia-producing upstream subpathway PWY-5698."", ""source_locator"": ""Pathway[@frameid=\""PWY0-41\""]/sub-pathways; reaction-list""}, {""reference_id"": ""MetaCyc:PWY-5698"", ""source_assertion"": ""PWY-5698 includes native reaction URUR-RXN."", ""source_locator"": ""Pathway[@frameid=\""PWY-5698\""]/reaction-list""}, {""reference_id"": ""MetaCyc:URUR-RXN"", ""source_assertion"": ""The native reaction links to RHEA:25242; its participants agree with the selected physiological transformation."", ""source_locator"": ""Reaction/left; Reaction/right; Reaction/dblink""}, {""reference_id"": ""RHEA:25241"", ""source_assertion"": ""RHEA:25241 has directional reaction RHEA:25242."", ""source_locator"": ""http://rdf.rhea-db.org/25241 rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:PWY-5698"", ""source_sha256"": ""a89a140f3dc86e1e05cc22c7cd90fed3cd3e20cfe15ad041961fa6a6c45a4071"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc PWY-5698"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5698""}, {""id"": ""MetaCyc:PWY0-41"", ""source_sha256"": ""c971c13063eaec46162a49000ceffb4c3d6fbfbc1e04ebf9f5ae4f3537065a93"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc PWY0-41"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-41""}, {""id"": ""MetaCyc:URUR-RXN"", ""source_sha256"": ""8aae4d1274bd5fe140d9f6678e153ffce7ca59d8ca777c9e2122f50c5bbde746"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc URUR-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:URUR-RXN""}, {""id"": ""RHEA:25241"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 25241 reaction family, selected direction 25242"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-035_26a4a24f1bc0	RHEA:15330	BFO:0000050	MetaCyc:PWY0-41	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-41|MetaCyc:RXN0-7024|RHEA:15329	Native pathway reaction, with the directed current Rhea chemistry independently resolved.	"[{""reference_id"": ""MetaCyc:PWY0-41"", ""source_assertion"": ""PWY0-41 includes native reaction RXN0-7024."", ""source_locator"": ""Pathway[@frameid=\""PWY0-41\""]/reaction-list""}, {""reference_id"": ""MetaCyc:RXN0-7024"", ""source_assertion"": ""The native reaction links to RHEA:15330; its participants agree with the selected physiological transformation."", ""source_locator"": ""Reaction/left; Reaction/right; Reaction/dblink""}, {""reference_id"": ""RHEA:15329"", ""source_assertion"": ""RHEA:15329 has directional reaction RHEA:15330."", ""source_locator"": ""http://rdf.rhea-db.org/15329 rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:PWY0-41"", ""source_sha256"": ""c971c13063eaec46162a49000ceffb4c3d6fbfbc1e04ebf9f5ae4f3537065a93"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc PWY0-41"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-41""}, {""id"": ""MetaCyc:RXN0-7024"", ""source_sha256"": ""b303a9a4e7386127917169e42e0f92e3dc56e39fc3e7ee0563eb431fe8909d66"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc RXN0-7024"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-7024""}, {""id"": ""RHEA:15329"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 15329 reaction family, selected direction 15330"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-036_8e0785ad1ef3	RHEA:22986	BFO:0000050	MetaCyc:PWY0-41	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:OXAMATE-CARBAMOYLTRANSFERASE-RXN|MetaCyc:PWY0-41|RHEA:22984	Native pathway reaction, with the directed current Rhea chemistry independently resolved. The mirror still marks the enzyme hypothetical; the 2024 AllFGH study supplies experimental support.	"[{""reference_id"": ""MetaCyc:PWY0-41"", ""source_assertion"": ""PWY0-41 includes native reaction OXAMATE-CARBAMOYLTRANSFERASE-RXN."", ""source_locator"": ""Pathway[@frameid=\""PWY0-41\""]/reaction-list""}, {""reference_id"": ""MetaCyc:OXAMATE-CARBAMOYLTRANSFERASE-RXN"", ""source_assertion"": ""The native reaction links to RHEA:22986; its participants agree with the selected physiological transformation."", ""source_locator"": ""Reaction/left; Reaction/right; Reaction/dblink""}, {""reference_id"": ""RHEA:22984"", ""source_assertion"": ""RHEA:22984 has directional reaction RHEA:22986."", ""source_locator"": ""http://rdf.rhea-db.org/22984 rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:OXAMATE-CARBAMOYLTRANSFERASE-RXN"", ""source_sha256"": ""7987b877bedd38fa20216c401f58a270e208b4b3ed4ab451ab49b09329c81a59"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc OXAMATE-CARBAMOYLTRANSFERASE-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:OXAMATE-CARBAMOYLTRANSFERASE-RXN""}, {""id"": ""MetaCyc:PWY0-41"", ""source_sha256"": ""c971c13063eaec46162a49000ceffb4c3d6fbfbc1e04ebf9f5ae4f3537065a93"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc PWY0-41"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-41""}, {""id"": ""RHEA:22984"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 22984 reaction family, selected direction 22986"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-037_c2a1048979a9	RHEA:30757	BFO:0000050	MetaCyc:PWY0-41	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-41|MetaCyc:RXN-14196|RHEA:30755	Native pathway reaction, with the directed current Rhea chemistry independently resolved.	"[{""reference_id"": ""MetaCyc:PWY0-41"", ""source_assertion"": ""PWY0-41 includes native reaction RXN-14196."", ""source_locator"": ""Pathway[@frameid=\""PWY0-41\""]/reaction-list""}, {""reference_id"": ""MetaCyc:RXN-14196"", ""source_assertion"": ""The native reaction links to RHEA:30758; its participants agree with the selected physiological transformation."", ""source_locator"": ""Reaction/left; Reaction/right; Reaction/dblink""}, {""reference_id"": ""RHEA:30755"", ""source_assertion"": ""RHEA:30755 has directional reaction RHEA:30757; native cross-reference RHEA:30758 is its bidirectional reaction."", ""source_locator"": ""http://rdf.rhea-db.org/30755 rh:directionalReaction; rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:PWY0-41"", ""source_sha256"": ""c971c13063eaec46162a49000ceffb4c3d6fbfbc1e04ebf9f5ae4f3537065a93"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc PWY0-41"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-41""}, {""id"": ""MetaCyc:RXN-14196"", ""source_sha256"": ""e1b24a3c1324b21eb0c3172cd7d21ca362071acdc20879a42dab77022356fccf"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc RXN-14196"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-14196""}, {""id"": ""RHEA:30755"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 30755 reaction family, selected direction 30757"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-038_d69153c8f9c8	RHEA:15650	BFO:0000050	MetaCyc:PWY0-41	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-41|MetaCyc:RXN0-5222|RHEA:15649	Spontaneous carbamate decomposition with the native CO2 endpoint; no enzyme is assigned. The bicarbonate alternative and combined kinase net are excluded to avoid duplicate chemistry.	"[{""reference_id"": ""MetaCyc:PWY0-41"", ""source_assertion"": ""PWY0-41 includes native reaction RXN0-5222."", ""source_locator"": ""Pathway[@frameid=\""PWY0-41\""]/reaction-list""}, {""reference_id"": ""MetaCyc:RXN0-5222"", ""source_assertion"": ""The native reaction links to RHEA:15650; its participants agree with the selected physiological transformation."", ""source_locator"": ""Reaction/left; Reaction/right; Reaction/dblink""}, {""reference_id"": ""RHEA:15649"", ""source_assertion"": ""RHEA:15649 has directional reaction RHEA:15650."", ""source_locator"": ""http://rdf.rhea-db.org/15649 rh:directionalReaction""}, {""reference_id"": ""MetaCyc:RXN0-5222"", ""source_assertion"": ""RXN0-5222 is marked spontaneous and converts carbamate plus two protons to ammonium and carbon dioxide."", ""source_locator"": ""Reaction/spontaneous; left; right; reaction-direction""}]"	"[{""id"": ""MetaCyc:PWY0-41"", ""source_sha256"": ""c971c13063eaec46162a49000ceffb4c3d6fbfbc1e04ebf9f5ae4f3537065a93"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc PWY0-41"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-41""}, {""id"": ""MetaCyc:RXN0-5222"", ""source_sha256"": ""079f6290beaaa757c83d0ef8fdf3e0eeef3ed2c02cd9aa37f8e469e068b21d36"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc RXN0-5222"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5222""}, {""id"": ""RHEA:15649"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 is the complete compressed RDF gzip"", ""title"": ""Rhea 15649 reaction family, selected direction 15650"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-039_ec1245a395af	UniProtKB:P77671	BFO:0000050	MetaCyc:CPLX-64	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-64|PMID:11092864|UniProtKB:P77671	4 identical P77671 subunits form this native assembly; the protein is not separately assigned isolated-subunit catalysis.	"[{""reference_id"": ""MetaCyc:CPLX-64"", ""source_assertion"": ""The native complex contains 4 copies of its protein monomer."", ""source_locator"": ""Protein/component/Protein; Protein/component/coefficient""}, {""reference_id"": ""UniProtKB:P77671"", ""source_assertion"": ""Homotetramer annotation supports the assembly; its BioCyc monomer cross-reference grounds the component identity. Evidence: ECO:0000269."", ""source_locator"": ""comments[6] SUBUNIT; uniProtKBCrossReferences[database=BioCyc]""}, {""reference_id"": ""PMID:11092864"", ""source_assertion"": ""The experimentally characterized protein is tetrameric."", ""source_locator"": ""Results, purification and native molecular-mass determination""}]"	"[{""id"": ""MetaCyc:CPLX-64"", ""source_sha256"": ""77ce25b4f49e54caa1b24ea6d316fade6124713adc17cbc0371a52ca62bbbf44"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc CPLX-64"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-64""}, {""id"": ""PMID:11092864"", ""source_sha256"": ""2f4e068944272532911d29449d7a133e5b995b1db7fa27984219f82364fb8304"", ""source_version"": ""full article HTML; retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""Functional expression and characterization of the two cyclic amidohydrolase enzymes, allantoinase and a novel phenylhydantoinase, from Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC94829/""}, {""id"": ""UniProtKB:P77671"", ""source_sha256"": ""d506ba7a7bd21613ad6dbdc1bd67b1dfeb06d55ac7558ece69ca48ca6cc39fd8"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P77671"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77671.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-040_b6655def3b09	UniProtKB:P77425	BFO:0000050	MetaCyc:CPLX-7524	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7524|PMID:17362992|UniProtKB:P77425	2 identical P77425 subunits form this native assembly; the protein is not separately assigned isolated-subunit catalysis.	"[{""reference_id"": ""MetaCyc:CPLX-7524"", ""source_assertion"": ""The native complex contains 2 copies of its protein monomer."", ""source_locator"": ""Protein/component/Protein; Protein/component/coefficient""}, {""reference_id"": ""UniProtKB:P77425"", ""source_assertion"": ""Homodimer annotation supports the assembly; its BioCyc monomer cross-reference grounds the component identity. Evidence: ECO:0000269."", ""source_locator"": ""comments[6] SUBUNIT; uniProtKBCrossReferences[database=BioCyc]""}, {""reference_id"": ""PMID:17362992"", ""source_assertion"": ""The AllC structural study describes its dimerization domain."", ""source_locator"": ""Abstract, dimerization domain and overall assembly""}]"	"[{""id"": ""MetaCyc:CPLX-7524"", ""source_sha256"": ""4bcbfbc55456c65eb5dd44811a3028b7124cf4ecc12c5424e6a9f4d1fd5e3cde"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc CPLX-7524"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7524""}, {""id"": ""PMID:17362992"", ""source_sha256"": ""8752189e192ffec0125e1750211c19a9973e72313c508ffd76811bb5b1345a29"", ""source_version"": ""Europe PMC core batch JSON; whole-response digest; abstract inspected; retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""Structural analysis of a ternary complex of allantoate amidohydrolase from Escherichia coli reveals its mechanics."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/17362992/""}, {""id"": ""UniProtKB:P77425"", ""source_sha256"": ""880e9d42e786beb498bf8e2e71c59fb0e4c769e06423a5ba3d15594ee0827907"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P77425"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77425.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-041_654d72f1bb56	UniProtKB:P77555	BFO:0000050	MetaCyc:CPLX0-7993	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7993|PMID:23284870|UniProtKB:P77555	2 identical P77555 subunits form this native assembly; the protein is not separately assigned isolated-subunit catalysis.	"[{""reference_id"": ""MetaCyc:CPLX0-7993"", ""source_assertion"": ""The native complex contains 2 copies of its protein monomer."", ""source_locator"": ""Protein/component/Protein; Protein/component/coefficient""}, {""reference_id"": ""UniProtKB:P77555"", ""source_assertion"": ""Homodimer annotation supports the assembly; its BioCyc monomer cross-reference grounds the component identity. Evidence: ECO:0000269."", ""source_locator"": ""comments[4] SUBUNIT; uniProtKBCrossReferences[database=BioCyc]""}, {""reference_id"": ""PMID:23284870"", ""source_assertion"": ""The experimentally characterized protein is dimeric."", ""source_locator"": ""Results/Overall Structure (s2a), size-exclusion chromatography and dimer interface""}]"	"[{""id"": ""MetaCyc:CPLX0-7993"", ""source_sha256"": ""ff02c7f27c5d12c3421819120b1a4baaddc0206e60196eb2fc211f0c48de3cb6"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc CPLX0-7993"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7993""}, {""id"": ""PMID:23284870"", ""source_sha256"": ""91a6d0ba2ff55fd60682255cc01d735412d8bca0b8f83b235b5717cdd0b70003"", ""source_version"": ""full article XML; supplemental Figure S2 independently inspected; retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""Structural and Functional Insights into (S)-Ureidoglycolate Dehydrogenase, a Metabolic Branch Point Enzyme in Nitrogen Utilization"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3527362/fullTextXML""}, {""id"": ""UniProtKB:P77555"", ""source_sha256"": ""57cc1f66190ec48c86a6169c71164adbba4e3a0270b9f63b83bee3fcaafd68e5"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P77555"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77555.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-042_96b4d4cfaa2e	MetaCyc:CPLX-64	pathwaymech:catalyzes	RHEA:17030	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-64|PMID:11092864|UniProtKB:P77671	Purified E. coli AllB hydrolyzes allantoin; the native tetramer is used as the catalyst.	"[{""reference_id"": ""UniProtKB:P77671"", ""source_assertion"": ""Catalytic activity identifies RHEA:17029 for this experimentally characterized protein. Evidence: ECO:0000269."", ""source_locator"": ""comments[1].reaction; evidences""}, {""reference_id"": ""PMID:11092864"", ""source_assertion"": ""Purified E. coli AllB hydrolyzes allantoin; the native tetramer is used as the catalyst."", ""source_locator"": ""Results, allantoinase purification and activity""}, {""reference_id"": ""MetaCyc:CPLX-64"", ""source_assertion"": ""The native assembly is linked to the corresponding enzymatic reaction."", ""source_locator"": ""Protein/catalyzes""}]"	"[{""id"": ""MetaCyc:CPLX-64"", ""source_sha256"": ""77ce25b4f49e54caa1b24ea6d316fade6124713adc17cbc0371a52ca62bbbf44"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc CPLX-64"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-64""}, {""id"": ""PMID:11092864"", ""source_sha256"": ""2f4e068944272532911d29449d7a133e5b995b1db7fa27984219f82364fb8304"", ""source_version"": ""full article HTML; retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""Functional expression and characterization of the two cyclic amidohydrolase enzymes, allantoinase and a novel phenylhydantoinase, from Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC94829/""}, {""id"": ""UniProtKB:P77671"", ""source_sha256"": ""d506ba7a7bd21613ad6dbdc1bd67b1dfeb06d55ac7558ece69ca48ca6cc39fd8"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P77671"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77671.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-043_fb1f744d1f98	MetaCyc:CPLX-7524	pathwaymech:catalyzes	RHEA:27486	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7524|PMID:20038185|UniProtKB:P77425	AllC produces S-ureidoglycine; separate AllE activity is needed for subsequent ureidoglycolate formation.	"[{""reference_id"": ""UniProtKB:P77425"", ""source_assertion"": ""Catalytic activity identifies RHEA:27485 for this experimentally characterized protein. Evidence: ECO:0000269."", ""source_locator"": ""comments[1].reaction; evidences""}, {""reference_id"": ""PMID:20038185"", ""source_assertion"": ""AllC produces S-ureidoglycine; separate AllE activity is needed for subsequent ureidoglycolate formation."", ""source_locator"": ""Abstract, reassignment of two successive bacterial reactions""}, {""reference_id"": ""MetaCyc:CPLX-7524"", ""source_assertion"": ""The native assembly is linked to the corresponding enzymatic reaction."", ""source_locator"": ""Protein/catalyzes""}]"	"[{""id"": ""MetaCyc:CPLX-7524"", ""source_sha256"": ""4bcbfbc55456c65eb5dd44811a3028b7124cf4ecc12c5424e6a9f4d1fd5e3cde"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc CPLX-7524"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7524""}, {""id"": ""PMID:20038185"", ""source_sha256"": ""8752189e192ffec0125e1750211c19a9973e72313c508ffd76811bb5b1345a29"", ""source_version"": ""Europe PMC core batch JSON; whole-response digest; abstract inspected; retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""Chemical basis of nitrogen recovery through the ureide pathway: formation and hydrolysis of S-ureidoglycine in plants and bacteria."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/20038185/""}, {""id"": ""UniProtKB:P77425"", ""source_sha256"": ""880e9d42e786beb498bf8e2e71c59fb0e4c769e06423a5ba3d15594ee0827907"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P77425"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77425.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-044_ad5f7625779a	MetaCyc:CPLX0-7993	pathwaymech:catalyzes	RHEA:15330	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7993|PMID:23284870|UniProtKB:P77555	AllD is an NAD-dependent ureidoglycolate dehydrogenase; the dimer is supported by structure and solution size exclusion.	"[{""reference_id"": ""UniProtKB:P77555"", ""source_assertion"": ""Catalytic activity identifies RHEA:15329 for this experimentally characterized protein. Evidence: ECO:0000269."", ""source_locator"": ""comments[1].reaction; evidences""}, {""reference_id"": ""PMID:23284870"", ""source_assertion"": ""AllD is an NAD-dependent ureidoglycolate dehydrogenase; the dimer is supported by structure and solution size exclusion."", ""source_locator"": ""Results s2a; Introduction, cofactor specificity; Figure S2""}, {""reference_id"": ""MetaCyc:CPLX0-7993"", ""source_assertion"": ""The native assembly is linked to the corresponding enzymatic reaction."", ""source_locator"": ""Protein/catalyzes""}]"	"[{""id"": ""MetaCyc:CPLX0-7993"", ""source_sha256"": ""ff02c7f27c5d12c3421819120b1a4baaddc0206e60196eb2fc211f0c48de3cb6"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""MetaCyc CPLX0-7993"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7993""}, {""id"": ""PMID:23284870"", ""source_sha256"": ""91a6d0ba2ff55fd60682255cc01d735412d8bca0b8f83b235b5717cdd0b70003"", ""source_version"": ""full article XML; supplemental Figure S2 independently inspected; retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""Structural and Functional Insights into (S)-Ureidoglycolate Dehydrogenase, a Metabolic Branch Point Enzyme in Nitrogen Utilization"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3527362/fullTextXML""}, {""id"": ""UniProtKB:P77555"", ""source_sha256"": ""57cc1f66190ec48c86a6169c71164adbba4e3a0270b9f63b83bee3fcaafd68e5"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P77555"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77555.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-045_3af7029f8152	UniProtKB:P75713	pathwaymech:catalyzes	RHEA:25242	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19935661|PMID:20038185|UniProtKB:P75713	AllE catalyzes the second, distinct hydrolysis to S-ureidoglycolate. Current monomer assignment is curator inference, not an experimental oligomerization claim.	"[{""reference_id"": ""UniProtKB:P75713"", ""source_assertion"": ""AllE catalytic activity is RHEA:25241 (experimental evidence PMID:19935661; curator inference PMID:20038185); SUBUNIT is monomer by curator inference."", ""source_locator"": ""comments[1].reaction; comments[3] SUBUNIT""}, {""reference_id"": ""PMID:19935661"", ""source_assertion"": ""Ureidoglycine aminohydrolase catalyzes formation of ureidoglycolate in the characterized ureide-degradation system."", ""source_locator"": ""Abstract""}, {""reference_id"": ""PMID:20038185"", ""source_assertion"": ""Bacterial AllE catalyzes the step after AllC produces S-ureidoglycine."", ""source_locator"": ""Abstract""}]"	"[{""id"": ""PMID:19935661"", ""source_sha256"": ""8752189e192ffec0125e1750211c19a9973e72313c508ffd76811bb5b1345a29"", ""source_version"": ""Europe PMC core batch JSON; whole-response digest; abstract inspected; retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""Ureide catabolism in Arabidopsis thaliana and Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/19935661/""}, {""id"": ""PMID:20038185"", ""source_sha256"": ""8752189e192ffec0125e1750211c19a9973e72313c508ffd76811bb5b1345a29"", ""source_version"": ""Europe PMC core batch JSON; whole-response digest; abstract inspected; retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""Chemical basis of nitrogen recovery through the ureide pathway: formation and hydrolysis of S-ureidoglycine in plants and bacteria."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/20038185/""}, {""id"": ""UniProtKB:P75713"", ""source_sha256"": ""157e35398d7aa8c6c0962b8b39458433bbc82489b78df0b9ce316183042cac5a"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P75713"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75713.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-046_5cb25e555eb6	UniProtKB:Q47208	pathwaymech:enables	RHEA:22986	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:38888336|UniProtKB:Q47208	Functional component of jointly required AllF/AllG/AllH oxamate carbamoyltransferase. No single-subunit sufficiency, resolved assembly stoichiometry, or formal graph AND gate is asserted. Purified reverse-direction assays used coexpressed protein and Mg2+; catabolic direction is supported by genetics and current annotation.	"[{""reference_id"": ""UniProtKB:Q47208"", ""source_assertion"": ""AllF/G/H are the three OXTCase component types (ECO:0000269); physiological RHEA:22986 direction is curator inference (ECO:0000305) from PMID:38888336."", ""source_locator"": ""comments[0] FUNCTION; comments[1].physiologicalReactions; comments[5] SUBUNIT""}, {""reference_id"": ""PMID:38888336"", ""source_assertion"": ""All three gene products jointly restore oxamate formation; coexpressed purified protein catalyzes the reverse oxamate-plus-carbamoyl-phosphate assay. Whole-assembly stoichiometry remains unresolved. Evidence: ECO:0000269."", ""source_locator"": ""Results s2-1 to s2-5; Tables 1-3; Discussion s3""}, {""reference_id"": ""PMID:38888336"", ""source_assertion"": ""Mg2+ dependence was tested on the enzyme preparation; purified assays used 10 mM MgCl2. This does not assign a metal-binding site to an isolated subunit."", ""source_locator"": ""Results s2-4, Figure 4C; Methods s4-5""}]"	"[{""id"": ""PMID:38888336"", ""source_sha256"": ""d61a5108373317363b296122cf150a497ddc11e657f0c4074d559c999bc06fb4"", ""source_version"": ""full article XML; retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""Oxamic transcarbamylase of Escherichia coli is\nencoded by the three genes allFGH (formerly fdrA,\nylbE, and ylbF)"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11326118/fullTextXML""}, {""id"": ""UniProtKB:Q47208"", ""source_sha256"": ""eb9f92309e0d0674eaa348c79d9a88c52fb6c46a54fdc4e857a5f63daf9fd83a"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB Q47208"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q47208.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-047_504368177f3d	UniProtKB:P77129	pathwaymech:enables	RHEA:22986	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:38888336|UniProtKB:P77129	Functional component of jointly required AllF/AllG/AllH oxamate carbamoyltransferase. No single-subunit sufficiency, resolved assembly stoichiometry, or formal graph AND gate is asserted. Purified reverse-direction assays used coexpressed protein and Mg2+; catabolic direction is supported by genetics and current annotation.	"[{""reference_id"": ""UniProtKB:P77129"", ""source_assertion"": ""AllF/G/H are the three OXTCase component types (ECO:0000269); physiological RHEA:22986 direction is curator inference (ECO:0000305) from PMID:38888336."", ""source_locator"": ""comments[0] FUNCTION; comments[1].physiologicalReactions; comments[5] SUBUNIT""}, {""reference_id"": ""PMID:38888336"", ""source_assertion"": ""All three gene products jointly restore oxamate formation; coexpressed purified protein catalyzes the reverse oxamate-plus-carbamoyl-phosphate assay. Whole-assembly stoichiometry remains unresolved. Evidence: ECO:0000269."", ""source_locator"": ""Results s2-1 to s2-5; Tables 1-3; Discussion s3""}, {""reference_id"": ""PMID:38888336"", ""source_assertion"": ""Mg2+ dependence was tested on the enzyme preparation; purified assays used 10 mM MgCl2. This does not assign a metal-binding site to an isolated subunit."", ""source_locator"": ""Results s2-4, Figure 4C; Methods s4-5""}]"	"[{""id"": ""PMID:38888336"", ""source_sha256"": ""d61a5108373317363b296122cf150a497ddc11e657f0c4074d559c999bc06fb4"", ""source_version"": ""full article XML; retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""Oxamic transcarbamylase of Escherichia coli is\nencoded by the three genes allFGH (formerly fdrA,\nylbE, and ylbF)"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11326118/fullTextXML""}, {""id"": ""UniProtKB:P77129"", ""source_sha256"": ""180bbf89c1261d225c5cbc2ff72d422c6fadfb2e73c98a6a05ec06c89dcc3cfb"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P77129"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77129.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-048_f2f992e4562b	UniProtKB:P0AAS5	pathwaymech:enables	RHEA:22986	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:38888336|UniProtKB:P0AAS5	Functional component of jointly required AllF/AllG/AllH oxamate carbamoyltransferase. No single-subunit sufficiency, resolved assembly stoichiometry, or formal graph AND gate is asserted. Purified reverse-direction assays used coexpressed protein and Mg2+; catabolic direction is supported by genetics and current annotation.	"[{""reference_id"": ""UniProtKB:P0AAS5"", ""source_assertion"": ""AllF/G/H are the three OXTCase component types (ECO:0000269); physiological RHEA:22986 direction is curator inference (ECO:0000305) from PMID:38888336."", ""source_locator"": ""comments[0] FUNCTION; comments[1].physiologicalReactions; comments[5] SUBUNIT""}, {""reference_id"": ""PMID:38888336"", ""source_assertion"": ""All three gene products jointly restore oxamate formation; coexpressed purified protein catalyzes the reverse oxamate-plus-carbamoyl-phosphate assay. Whole-assembly stoichiometry remains unresolved. Evidence: ECO:0000269."", ""source_locator"": ""Results s2-1 to s2-5; Tables 1-3; Discussion s3""}, {""reference_id"": ""PMID:38888336"", ""source_assertion"": ""Mg2+ dependence was tested on the enzyme preparation; purified assays used 10 mM MgCl2. This does not assign a metal-binding site to an isolated subunit."", ""source_locator"": ""Results s2-4, Figure 4C; Methods s4-5""}]"	"[{""id"": ""PMID:38888336"", ""source_sha256"": ""d61a5108373317363b296122cf150a497ddc11e657f0c4074d559c999bc06fb4"", ""source_version"": ""full article XML; retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""Oxamic transcarbamylase of Escherichia coli is\nencoded by the three genes allFGH (formerly fdrA,\nylbE, and ylbF)"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11326118/fullTextXML""}, {""id"": ""UniProtKB:P0AAS5"", ""source_sha256"": ""cc018efb39ebb4354bf3b10321ae501c835bcda101256d3d04b726e37fa2b04d"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P0AAS5"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AAS5.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-049_de5b2460cc29	UniProtKB:P37306	pathwaymech:enables	RHEA:30757	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:36384810|UniProtKB:P37306	AllK (YbcF) supplies ATP-forming carbamate kinase activity; no unverified oligomeric state is imposed. The assay used 30 mM MgCl2 without establishing an isolated enzyme-metal binding requirement. Carbamate decomposition is represented separately.	"[{""reference_id"": ""UniProtKB:P37306"", ""source_assertion"": ""The component kinase reaction RHEA:30755 and physiological direction RHEA:30757 have ECO:0000305 evidence from PMID:36384810; the combined bicarbonate net is a separate annotation. Evidence: ECO:0000305."", ""source_locator"": ""comments[2].reaction; comments[2].physiologicalReactions""}, {""reference_id"": ""PMID:36384810"", ""source_assertion"": ""Purified YbcF generated ATP from carbamoyl phosphate and ADP; substrate-dependent kinetics establish catabolic carbamate kinase activity. Evidence: ECO:0000269."", ""source_locator"": ""Results sec15, Figures 4-6; Methods, Carbamate Kinase Assay""}]"	"[{""id"": ""PMID:36384810"", ""source_sha256"": ""cba5edd372681424c8d07a74240169c3ebd714670ff106702d148909314525da"", ""source_version"": ""full article XML; retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""The ybcF Gene of Escherichia coli Encodes a Local Orphan Enzyme, Catabolic Carbamate Kinase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9843812/fullTextXML""}, {""id"": ""UniProtKB:P37306"", ""source_sha256"": ""2ec54b5434cef9677b0bb0b68c48d051dcad0d7b5634882c8276c7a0a243697f"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P37306"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37306.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-050_e3b8db7c5ecb	MetaCyc:CPLX-64	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12486048|UniProtKB:P77671	AllB metal alternative supported by current annotation. Zinc, nickel, cobalt and manganese are not four simultaneous requirements; measured metal occupancy and stereoselectivity depend on preparation.	"[{""reference_id"": ""UniProtKB:P77671"", ""source_assertion"": ""AllB uses Zn2+ and can also use Ni2+, Co2+ or Mn2+; the annotation combines experimental and curator-inference evidence."", ""source_locator"": ""comments[2] COFACTOR; cofactors; note""}, {""reference_id"": ""PMID:12486048"", ""source_assertion"": ""Metal-substituted E. coli allantoinase preparations differ in activity and substrate stereoselectivity; measured metal occupancy is preparation dependent."", ""source_locator"": ""Abstract; Results, metal analyses and substrate specificity""}]"	"[{""id"": ""PMID:12486048"", ""source_sha256"": ""b10a113c20794a750b2c58a1fdae1278800153b085f1d18b329f258b0b0665b4"", ""source_version"": ""full article HTML; retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""Metal ion dependence of recombinant Escherichia coli allantoinase."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC141845/""}, {""id"": ""UniProtKB:P77671"", ""source_sha256"": ""d506ba7a7bd21613ad6dbdc1bd67b1dfeb06d55ac7558ece69ca48ca6cc39fd8"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P77671"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77671.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-051_7f88321f955b	MetaCyc:CPLX-64	pathwaymech:has_cofactor	CHEBI:49786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12486048|UniProtKB:P77671	AllB metal alternative supported by current annotation. Zinc, nickel, cobalt and manganese are not four simultaneous requirements; measured metal occupancy and stereoselectivity depend on preparation.	"[{""reference_id"": ""UniProtKB:P77671"", ""source_assertion"": ""AllB uses Zn2+ and can also use Ni2+, Co2+ or Mn2+; the annotation combines experimental and curator-inference evidence."", ""source_locator"": ""comments[2] COFACTOR; cofactors; note""}, {""reference_id"": ""PMID:12486048"", ""source_assertion"": ""Metal-substituted E. coli allantoinase preparations differ in activity and substrate stereoselectivity; measured metal occupancy is preparation dependent."", ""source_locator"": ""Abstract; Results, metal analyses and substrate specificity""}]"	"[{""id"": ""PMID:12486048"", ""source_sha256"": ""b10a113c20794a750b2c58a1fdae1278800153b085f1d18b329f258b0b0665b4"", ""source_version"": ""full article HTML; retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""Metal ion dependence of recombinant Escherichia coli allantoinase."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC141845/""}, {""id"": ""UniProtKB:P77671"", ""source_sha256"": ""d506ba7a7bd21613ad6dbdc1bd67b1dfeb06d55ac7558ece69ca48ca6cc39fd8"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P77671"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77671.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-052_f7cc194955a0	MetaCyc:CPLX-64	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12486048|UniProtKB:P77671	AllB metal alternative supported by current annotation. Zinc, nickel, cobalt and manganese are not four simultaneous requirements; measured metal occupancy and stereoselectivity depend on preparation.	"[{""reference_id"": ""UniProtKB:P77671"", ""source_assertion"": ""AllB uses Zn2+ and can also use Ni2+, Co2+ or Mn2+; the annotation combines experimental and curator-inference evidence."", ""source_locator"": ""comments[2] COFACTOR; cofactors; note""}, {""reference_id"": ""PMID:12486048"", ""source_assertion"": ""Metal-substituted E. coli allantoinase preparations differ in activity and substrate stereoselectivity; measured metal occupancy is preparation dependent."", ""source_locator"": ""Abstract; Results, metal analyses and substrate specificity""}]"	"[{""id"": ""PMID:12486048"", ""source_sha256"": ""b10a113c20794a750b2c58a1fdae1278800153b085f1d18b329f258b0b0665b4"", ""source_version"": ""full article HTML; retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""Metal ion dependence of recombinant Escherichia coli allantoinase."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC141845/""}, {""id"": ""UniProtKB:P77671"", ""source_sha256"": ""d506ba7a7bd21613ad6dbdc1bd67b1dfeb06d55ac7558ece69ca48ca6cc39fd8"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P77671"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77671.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-053_3ee962759494	MetaCyc:CPLX-64	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12486048|UniProtKB:P77671	AllB metal alternative supported by current annotation. Zinc, nickel, cobalt and manganese are not four simultaneous requirements; measured metal occupancy and stereoselectivity depend on preparation.	"[{""reference_id"": ""UniProtKB:P77671"", ""source_assertion"": ""AllB uses Zn2+ and can also use Ni2+, Co2+ or Mn2+; the annotation combines experimental and curator-inference evidence."", ""source_locator"": ""comments[2] COFACTOR; cofactors; note""}, {""reference_id"": ""PMID:12486048"", ""source_assertion"": ""Metal-substituted E. coli allantoinase preparations differ in activity and substrate stereoselectivity; measured metal occupancy is preparation dependent."", ""source_locator"": ""Abstract; Results, metal analyses and substrate specificity""}]"	"[{""id"": ""PMID:12486048"", ""source_sha256"": ""b10a113c20794a750b2c58a1fdae1278800153b085f1d18b329f258b0b0665b4"", ""source_version"": ""full article HTML; retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""Metal ion dependence of recombinant Escherichia coli allantoinase."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC141845/""}, {""id"": ""UniProtKB:P77671"", ""source_sha256"": ""d506ba7a7bd21613ad6dbdc1bd67b1dfeb06d55ac7558ece69ca48ca6cc39fd8"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P77671"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77671.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-054_8fa55fc4bc98	MetaCyc:CPLX-7524	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:17362992|UniProtKB:P77425	The earlier AllC structure reports two Zn2+ ions per subunit; this bound-metal annotation does not establish zinc as the unique physiological metal.	"[{""reference_id"": ""UniProtKB:P77425"", ""source_assertion"": ""The earlier AllC structure reports two Zn2+ ions per subunit; this bound-metal annotation does not establish zinc as the unique physiological metal. Evidence: ECO:0000269."", ""source_locator"": ""comments[2] COFACTOR; note""}, {""reference_id"": ""PMID:17362992"", ""source_assertion"": ""The study supports the binuclear zinc-containing AllC active center."", ""source_locator"": ""Abstract""}]"	"[{""id"": ""PMID:17362992"", ""source_sha256"": ""8752189e192ffec0125e1750211c19a9973e72313c508ffd76811bb5b1345a29"", ""source_version"": ""Europe PMC core batch JSON; whole-response digest; abstract inspected; retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""Structural analysis of a ternary complex of allantoate amidohydrolase from Escherichia coli reveals its mechanics."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/17362992/""}, {""id"": ""UniProtKB:P77425"", ""source_sha256"": ""880e9d42e786beb498bf8e2e71c59fb0e4c769e06423a5ba3d15594ee0827907"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P77425"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77425.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-055_31fa5486466e	MetaCyc:CPLX-7524	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:20038185|UniProtKB:P77425	AllC can bind Mn2+; subsequent functional work characterizes manganese-dependent chemistry. Metal selection is source- and preparation-dependent.	"[{""reference_id"": ""UniProtKB:P77425"", ""source_assertion"": ""AllC can bind Mn2+; subsequent functional work characterizes manganese-dependent chemistry. Metal selection is source- and preparation-dependent. Evidence: ECO:0000269."", ""source_locator"": ""comments[2] COFACTOR; note""}, {""reference_id"": ""PMID:20038185"", ""source_assertion"": ""The study supports manganese-dependent activity in the bacterial AllC/AllE degradation sequence."", ""source_locator"": ""Abstract""}]"	"[{""id"": ""PMID:20038185"", ""source_sha256"": ""8752189e192ffec0125e1750211c19a9973e72313c508ffd76811bb5b1345a29"", ""source_version"": ""Europe PMC core batch JSON; whole-response digest; abstract inspected; retrieved 2026-10-10 (America/Los_Angeles)"", ""title"": ""Chemical basis of nitrogen recovery through the ureide pathway: formation and hydrolysis of S-ureidoglycine in plants and bacteria."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/20038185/""}, {""id"": ""UniProtKB:P77425"", ""source_sha256"": ""880e9d42e786beb498bf8e2e71c59fb0e4c769e06423a5ba3d15594ee0827907"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P77425"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77425.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-056_958ac27ec367	UniProtKB:P75713	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P75713	AllE uses manganese and can alternatively use cobalt; these are alternatives, not simultaneous requirements.	"[{""reference_id"": ""UniProtKB:P75713"", ""source_assertion"": ""AllE has Mn2+ as cofactor and can also use Co2+, with experimental evidence from PMID:20038185. Evidence: ECO:0000269."", ""source_locator"": ""comments[2] COFACTOR; note""}]"	"[{""id"": ""UniProtKB:P75713"", ""source_sha256"": ""157e35398d7aa8c6c0962b8b39458433bbc82489b78df0b9ce316183042cac5a"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P75713"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75713.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-057_418e49e619e1	UniProtKB:P75713	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P75713	AllE uses manganese and can alternatively use cobalt; these are alternatives, not simultaneous requirements.	"[{""reference_id"": ""UniProtKB:P75713"", ""source_assertion"": ""AllE has Mn2+ as cofactor and can also use Co2+, with experimental evidence from PMID:20038185. Evidence: ECO:0000269."", ""source_locator"": ""comments[2] COFACTOR; note""}]"	"[{""id"": ""UniProtKB:P75713"", ""source_sha256"": ""157e35398d7aa8c6c0962b8b39458433bbc82489b78df0b9ce316183042cac5a"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P75713"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75713.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-058_ac3e7b342baf	UniProtKB:P77425	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77425	Protein-level cytoplasmic localization; the cited annotation evidence grade is retained and not extended to unannotated partners.	"[{""reference_id"": ""UniProtKB:P77425"", ""source_assertion"": ""The protein is annotated in the cytoplasm (SL-0086). Evidence: ECO:0000305."", ""source_locator"": ""comments[7] SUBCELLULAR LOCATION""}]"	"[{""id"": ""UniProtKB:P77425"", ""source_sha256"": ""880e9d42e786beb498bf8e2e71c59fb0e4c769e06423a5ba3d15594ee0827907"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P77425"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77425.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-059_f53b5cd71dbc	UniProtKB:P75713	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P75713	Protein-level cytoplasmic localization; the cited annotation evidence grade is retained and not extended to unannotated partners.	"[{""reference_id"": ""UniProtKB:P75713"", ""source_assertion"": ""The protein is annotated in the cytoplasm (SL-0086). Evidence: ECO:0000269."", ""source_locator"": ""comments[4] SUBCELLULAR LOCATION""}]"	"[{""id"": ""UniProtKB:P75713"", ""source_sha256"": ""157e35398d7aa8c6c0962b8b39458433bbc82489b78df0b9ce316183042cac5a"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P75713"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75713.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-060_2bdcccd76504	UniProtKB:P77555	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77555	Protein-level cytoplasmic localization; the cited annotation evidence grade is retained and not extended to unannotated partners.	"[{""reference_id"": ""UniProtKB:P77555"", ""source_assertion"": ""The protein is annotated in the cytoplasm (SL-0086). Evidence: ECO:0000305."", ""source_locator"": ""comments[5] SUBCELLULAR LOCATION""}]"	"[{""id"": ""UniProtKB:P77555"", ""source_sha256"": ""57cc1f66190ec48c86a6169c71164adbba4e3a0270b9f63b83bee3fcaafd68e5"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P77555"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77555.json""}]"	""
pathwaymech:MetaCyc_PWY0-41_allantoin-anaerobic-edge-061_b49464e233aa	UniProtKB:P37306	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37306	Protein-level cytoplasmic localization; the cited annotation evidence grade is retained and not extended to unannotated partners.	"[{""reference_id"": ""UniProtKB:P37306"", ""source_assertion"": ""The protein is annotated in the cytoplasm (SL-0086). Evidence: ECO:0000305."", ""source_locator"": ""comments[6] SUBCELLULAR LOCATION""}]"	"[{""id"": ""UniProtKB:P37306"", ""source_sha256"": ""2ec54b5434cef9677b0bb0b68c48d051dcad0d7b5634882c8276c7a0a243697f"", ""source_version"": ""2026_03 (2026-09-02); retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P37306"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37306.json""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-001_a10110006bbf	gomodel:ALLANTOICASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:ALLANTOICASE-RXN RO:0002233 gomodel:CHEBI_15377_ALLANTOICASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/0; endpoint types: /individuals/0/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-002_106f94e4559e	gomodel:ALLANTOINASE-RXN	RO:0002233	CHEBI:15678	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:ALLANTOINASE-RXN RO:0002233 gomodel:CHEBI_15678_ALLANTOINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/1; endpoint types: /individuals/1/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-003_7fd8b236a837	gomodel:UREIDOGLYCOLATE-LYASE-RXN	BFO:0000050	GO:0000256	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:UREIDOGLYCOLATE-LYASE-RXN BFO:0000050 gomodel:YeastPathways_PWY-5694/YeastPathways_PWY-5694."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/2; endpoint types: /individuals/11/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-004_ab814d1eaf39	SGD:S000001466	pathwaymech:enables	gomodel:ALLANTOINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:ALLANTOINASE-RXN RO:0002333 gomodel:YIR027C-MONOMER_ALLANTOINASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/3; endpoint types: /individuals/1/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-005_3da615d0d22b	gomodel:ALLANTOINASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:ALLANTOINASE-RXN RO:0002234 gomodel:CHEBI_15378_ALLANTOINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/4; endpoint types: /individuals/1/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-006_7c78a0a1a6ab	gomodel:ALLANTOICASE-RXN	RO:0002234	CHEBI:16199	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:ALLANTOICASE-RXN RO:0002234 gomodel:CHEBI_16199_ALLANTOICASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/5; endpoint types: /individuals/0/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-007_ddbd6419bcb1	gomodel:ALLANTOINASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:ALLANTOINASE-RXN BFO:0000066 gomodel:reaction_ALLANTOINASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/6; endpoint types: /individuals/1/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-008_461f9154961a	gomodel:UREIDOGLYCOLATE-LYASE-RXN	RO:0002233	CHEBI:57296	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:UREIDOGLYCOLATE-LYASE-RXN RO:0002233 gomodel:CHEBI_57296_ALLANTOICASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/7; endpoint types: /individuals/11/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-009_958d4009904e	gomodel:UREIDOGLYCOLATE-LYASE-RXN	RO:0002234	CHEBI:36655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:UREIDOGLYCOLATE-LYASE-RXN RO:0002234 gomodel:CHEBI_36655_UREIDOGLYCOLATE-LYASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/8; endpoint types: /individuals/11/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-010_fe65197a7e19	gomodel:ALLANTOICASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:ALLANTOICASE-RXN BFO:0000066 gomodel:reaction_ALLANTOICASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/9; endpoint types: /individuals/0/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-011_8f92a7fcd3ba	SGD:S000001468	pathwaymech:enables	gomodel:ALLANTOICASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:ALLANTOICASE-RXN RO:0002333 gomodel:YIR029W-MONOMER_ALLANTOICASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/10; endpoint types: /individuals/0/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-012_e2594e27faf8	gomodel:ALLANTOICASE-RXN	BFO:0000050	GO:0000256	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:ALLANTOICASE-RXN BFO:0000050 gomodel:YeastPathways_PWY-5694/YeastPathways_PWY-5694."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/11; endpoint types: /individuals/0/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-013_b2c82ca208e6	SGD:S000001471	pathwaymech:enables	gomodel:UREIDOGLYCOLATE-LYASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:UREIDOGLYCOLATE-LYASE-RXN RO:0002333 gomodel:YIR032C-MONOMER_UREIDOGLYCOLATE-LYASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/12; endpoint types: /individuals/11/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-014_290b8fa23bd0	gomodel:UREIDOGLYCOLATE-LYASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:UREIDOGLYCOLATE-LYASE-RXN BFO:0000066 gomodel:reaction_UREIDOGLYCOLATE-LYASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/13; endpoint types: /individuals/11/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-015_3b66f9c5da76	gomodel:UREIDOGLYCOLATE-LYASE-RXN	RO:0002234	CHEBI:16199	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:UREIDOGLYCOLATE-LYASE-RXN RO:0002234 gomodel:CHEBI_16199_UREIDOGLYCOLATE-LYASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/14; endpoint types: /individuals/11/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-016_05d820b06773	gomodel:ALLANTOINASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:ALLANTOINASE-RXN RO:0002233 gomodel:CHEBI_15377_ALLANTOINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/15; endpoint types: /individuals/1/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-017_f00b45178494	gomodel:ALLANTOINASE-RXN	RO:0002234	CHEBI:17536	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:ALLANTOINASE-RXN RO:0002234 gomodel:CHEBI_17536_ALLANTOINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/16; endpoint types: /individuals/1/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-018_3838bb8af6a5	gomodel:ALLANTOICASE-RXN	RO:0002234	CHEBI:57296	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:ALLANTOICASE-RXN RO:0002234 gomodel:CHEBI_57296_ALLANTOICASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/17; endpoint types: /individuals/0/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-019_8d58e216479c	gomodel:ALLANTOICASE-RXN	RO:0002233	CHEBI:17536	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:ALLANTOICASE-RXN RO:0002233 gomodel:CHEBI_17536_ALLANTOINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/18; endpoint types: /individuals/0/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_edge-020_f6ed1eae081c	gomodel:ALLANTOINASE-RXN	BFO:0000050	GO:0000256	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5694		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5694"", ""source_assertion"": ""The model asserts gomodel:ALLANTOINASE-RXN BFO:0000050 gomodel:YeastPathways_PWY-5694/YeastPathways_PWY-5694."", ""source_locator"": ""./YeastPathways_PWY-5694.json#/facts/19; endpoint types: /individuals/1/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5694"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-02-19; member ./YeastPathways_PWY-5694.json"", ""title"": ""GO-CAM allantoin degradation to glyoxylate I model YeastPathways_PWY-5694"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5694_cofactor-1810880c4756_ff2491f59d96	SGD:S000001466	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32375	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P32375"", ""source_assertion"": ""UniProtKB:P32375 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4531/comments/0/cofactors/0; /results/4531/comments/0/note""}, {""reference_id"": ""UniProtKB:P32375"", ""source_assertion"": ""UniProtKB:P32375 has the exact SGD cross-reference SGD:S000001466."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4531/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32375"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P32375 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-001_d7f951ad73a3	CHEBI:15678	pathwaymech:consumes	RHEA:17030	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17029	Coefficient 1 in the selected directed Rhea equation; source charge and stereochemistry are retained.	"[{""reference_id"": ""RHEA:17029"", ""source_assertion"": ""RHEA:17030 substrates contain CHEBI:15678 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17030 rh:substrates; http://rdf.rhea-db.org/17029_L rh:contains1 http://rdf.rhea-db.org/Participant_17029_compound_2545; http://rdf.rhea-db.org/Participant_17029_compound_2545 rh:compound http://rdf.rhea-db.org/Compound_2545; http://rdf.rhea-db.org/Compound_2545 rh:accession""}]"	"[{""id"": ""RHEA:17029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 17029 reaction family; selected 17030"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-002_a49dfbc42049	CHEBI:15377	pathwaymech:consumes	RHEA:17030	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17029	Coefficient 1 in the selected directed Rhea equation; source charge and stereochemistry are retained.	"[{""reference_id"": ""RHEA:17029"", ""source_assertion"": ""RHEA:17030 substrates contain CHEBI:15377 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17030 rh:substrates; http://rdf.rhea-db.org/17029_L rh:contains1 http://rdf.rhea-db.org/Participant_17029_compound_1283; http://rdf.rhea-db.org/Participant_17029_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; http://rdf.rhea-db.org/Compound_1283 rh:accession""}]"	"[{""id"": ""RHEA:17029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 17029 reaction family; selected 17030"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-003_cfc771da394e	RHEA:17030	pathwaymech:produces	CHEBI:17536	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17029	Coefficient 1 in the selected directed Rhea equation; source charge and stereochemistry are retained.	"[{""reference_id"": ""RHEA:17029"", ""source_assertion"": ""RHEA:17030 products contain CHEBI:17536 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17030 rh:products; http://rdf.rhea-db.org/17029_R rh:contains1 http://rdf.rhea-db.org/Participant_17029_compound_4604; http://rdf.rhea-db.org/Participant_17029_compound_4604 rh:compound http://rdf.rhea-db.org/Compound_4604; http://rdf.rhea-db.org/Compound_4604 rh:accession""}]"	"[{""id"": ""RHEA:17029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 17029 reaction family; selected 17030"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-004_6d880e4ddef9	RHEA:17030	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17029	Coefficient 1 in the selected directed Rhea equation; source charge and stereochemistry are retained.	"[{""reference_id"": ""RHEA:17029"", ""source_assertion"": ""RHEA:17030 products contain CHEBI:15378 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17030 rh:products; http://rdf.rhea-db.org/17029_R rh:contains1 http://rdf.rhea-db.org/Participant_17029_compound_3249; http://rdf.rhea-db.org/Participant_17029_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; http://rdf.rhea-db.org/Compound_3249 rh:accession""}]"	"[{""id"": ""RHEA:17029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 17029 reaction family; selected 17030"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-005_080a7be8d11b	CHEBI:17536	pathwaymech:consumes	RHEA:27486	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27485	Coefficient 1 in the selected directed Rhea equation; source charge and stereochemistry are retained.	"[{""reference_id"": ""RHEA:27485"", ""source_assertion"": ""RHEA:27486 substrates contain CHEBI:17536 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/27486 rh:substrates; http://rdf.rhea-db.org/27485_L rh:contains1 http://rdf.rhea-db.org/Participant_27485_compound_4604; http://rdf.rhea-db.org/Participant_27485_compound_4604 rh:compound http://rdf.rhea-db.org/Compound_4604; http://rdf.rhea-db.org/Compound_4604 rh:accession""}]"	"[{""id"": ""RHEA:27485"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 27485 reaction family; selected 27486"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-006_5c2f0462a8fc	CHEBI:15377	pathwaymech:consumes	RHEA:27486	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27485	Coefficient 1 in the selected directed Rhea equation; source charge and stereochemistry are retained.	"[{""reference_id"": ""RHEA:27485"", ""source_assertion"": ""RHEA:27486 substrates contain CHEBI:15377 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/27486 rh:substrates; http://rdf.rhea-db.org/27485_L rh:contains1 http://rdf.rhea-db.org/Participant_27485_compound_1283; http://rdf.rhea-db.org/Participant_27485_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; http://rdf.rhea-db.org/Compound_1283 rh:accession""}]"	"[{""id"": ""RHEA:27485"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 27485 reaction family; selected 27486"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-007_52c30e763fb7	CHEBI:15378	pathwaymech:consumes	RHEA:27486	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27485	Coefficient 2 in the selected directed Rhea equation; source charge and stereochemistry are retained.	"[{""reference_id"": ""RHEA:27485"", ""source_assertion"": ""RHEA:27486 substrates contain CHEBI:15378 with coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/27486 rh:substrates; http://rdf.rhea-db.org/27485_L rh:contains2 http://rdf.rhea-db.org/Participant_27485_compound_3249; http://rdf.rhea-db.org/Participant_27485_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; http://rdf.rhea-db.org/Compound_3249 rh:accession""}]"	"[{""id"": ""RHEA:27485"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 27485 reaction family; selected 27486"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-008_1aaa31f619e1	RHEA:27486	pathwaymech:produces	CHEBI:59947	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27485	Coefficient 1 in the selected directed Rhea equation; source charge and stereochemistry are retained.	"[{""reference_id"": ""RHEA:27485"", ""source_assertion"": ""RHEA:27486 products contain CHEBI:59947 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/27486 rh:products; http://rdf.rhea-db.org/27485_R rh:contains1 http://rdf.rhea-db.org/Participant_27485_compound_6148; http://rdf.rhea-db.org/Participant_27485_compound_6148 rh:compound http://rdf.rhea-db.org/Compound_6148; http://rdf.rhea-db.org/Compound_6148 rh:accession""}]"	"[{""id"": ""RHEA:27485"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 27485 reaction family; selected 27486"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-009_c5c44d33ab31	RHEA:27486	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27485	Coefficient 1 in the selected directed Rhea equation; source charge and stereochemistry are retained.	"[{""reference_id"": ""RHEA:27485"", ""source_assertion"": ""RHEA:27486 products contain CHEBI:28938 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/27486 rh:products; http://rdf.rhea-db.org/27485_R rh:contains1 http://rdf.rhea-db.org/Participant_27485_compound_1012; http://rdf.rhea-db.org/Participant_27485_compound_1012 rh:compound http://rdf.rhea-db.org/Compound_1012; http://rdf.rhea-db.org/Compound_1012 rh:accession""}]"	"[{""id"": ""RHEA:27485"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 27485 reaction family; selected 27486"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-010_316e5a7d92b4	RHEA:27486	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27485	Coefficient 1 in the selected directed Rhea equation; source charge and stereochemistry are retained.	"[{""reference_id"": ""RHEA:27485"", ""source_assertion"": ""RHEA:27486 products contain CHEBI:16526 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/27486 rh:products; http://rdf.rhea-db.org/27485_R rh:contains1 http://rdf.rhea-db.org/Participant_27485_compound_4391; http://rdf.rhea-db.org/Participant_27485_compound_4391 rh:compound http://rdf.rhea-db.org/Compound_4391; http://rdf.rhea-db.org/Compound_4391 rh:accession""}]"	"[{""id"": ""RHEA:27485"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 27485 reaction family; selected 27486"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-011_7f4c871b3bf2	CHEBI:59947	pathwaymech:consumes	RHEA:25242	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25241	Coefficient 1 in the selected directed Rhea equation; source charge and stereochemistry are retained.	"[{""reference_id"": ""RHEA:25241"", ""source_assertion"": ""RHEA:25242 substrates contain CHEBI:59947 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25242 rh:substrates; http://rdf.rhea-db.org/25241_L rh:contains1 http://rdf.rhea-db.org/Participant_25241_compound_6148; http://rdf.rhea-db.org/Participant_25241_compound_6148 rh:compound http://rdf.rhea-db.org/Compound_6148; http://rdf.rhea-db.org/Compound_6148 rh:accession""}]"	"[{""id"": ""RHEA:25241"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 25241 reaction family; selected 25242"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-012_55a630f971d7	CHEBI:15377	pathwaymech:consumes	RHEA:25242	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25241	Coefficient 1 in the selected directed Rhea equation; source charge and stereochemistry are retained.	"[{""reference_id"": ""RHEA:25241"", ""source_assertion"": ""RHEA:25242 substrates contain CHEBI:15377 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25242 rh:substrates; http://rdf.rhea-db.org/25241_L rh:contains1 http://rdf.rhea-db.org/Participant_25241_compound_1283; http://rdf.rhea-db.org/Participant_25241_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; http://rdf.rhea-db.org/Compound_1283 rh:accession""}]"	"[{""id"": ""RHEA:25241"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 25241 reaction family; selected 25242"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-013_7c27d81d2471	RHEA:25242	pathwaymech:produces	CHEBI:57296	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25241	Coefficient 1 in the selected directed Rhea equation; source charge and stereochemistry are retained.	"[{""reference_id"": ""RHEA:25241"", ""source_assertion"": ""RHEA:25242 products contain CHEBI:57296 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25242 rh:products; http://rdf.rhea-db.org/25241_R rh:contains1 http://rdf.rhea-db.org/Participant_25241_compound_4140; http://rdf.rhea-db.org/Participant_25241_compound_4140 rh:compound http://rdf.rhea-db.org/Compound_4140; http://rdf.rhea-db.org/Compound_4140 rh:accession""}]"	"[{""id"": ""RHEA:25241"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 25241 reaction family; selected 25242"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-014_e8fb1777a78e	RHEA:25242	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25241	Coefficient 1 in the selected directed Rhea equation; source charge and stereochemistry are retained.	"[{""reference_id"": ""RHEA:25241"", ""source_assertion"": ""RHEA:25242 products contain CHEBI:28938 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25242 rh:products; http://rdf.rhea-db.org/25241_R rh:contains1 http://rdf.rhea-db.org/Participant_25241_compound_1012; http://rdf.rhea-db.org/Participant_25241_compound_1012 rh:compound http://rdf.rhea-db.org/Compound_1012; http://rdf.rhea-db.org/Compound_1012 rh:accession""}]"	"[{""id"": ""RHEA:25241"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 25241 reaction family; selected 25242"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-015_7281dc34dbe9	CHEBI:57296	pathwaymech:consumes	RHEA:11305	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11304	Coefficient 1 in the selected directed Rhea equation; source charge and stereochemistry are retained. This is the urea-releasing lyase equation; the primary study notes glyoxylate hydration in solution and does not experimentally exclude water participation in the elementary mechanism.	"[{""reference_id"": ""RHEA:11304"", ""source_assertion"": ""RHEA:11305 substrates contain CHEBI:57296 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/11305 rh:substrates; http://rdf.rhea-db.org/11304_L rh:contains1 http://rdf.rhea-db.org/Participant_11304_compound_4140; http://rdf.rhea-db.org/Participant_11304_compound_4140 rh:compound http://rdf.rhea-db.org/Compound_4140; http://rdf.rhea-db.org/Compound_4140 rh:accession""}]"	"[{""id"": ""RHEA:11304"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 11304 reaction family; selected 11305"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-016_0e0fa19b4c8a	RHEA:11305	pathwaymech:produces	CHEBI:16199	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11304	Coefficient 1 in the selected directed Rhea equation; source charge and stereochemistry are retained. This is the urea-releasing lyase equation; the primary study notes glyoxylate hydration in solution and does not experimentally exclude water participation in the elementary mechanism.	"[{""reference_id"": ""RHEA:11304"", ""source_assertion"": ""RHEA:11305 products contain CHEBI:16199 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/11305 rh:products; http://rdf.rhea-db.org/11304_R rh:contains1 http://rdf.rhea-db.org/Participant_11304_compound_3216; http://rdf.rhea-db.org/Participant_11304_compound_3216 rh:compound http://rdf.rhea-db.org/Compound_3216; http://rdf.rhea-db.org/Compound_3216 rh:accession""}]"	"[{""id"": ""RHEA:11304"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 11304 reaction family; selected 11305"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-017_bc95264da18a	RHEA:11305	pathwaymech:produces	CHEBI:36655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11304	Coefficient 1 in the selected directed Rhea equation; source charge and stereochemistry are retained. This is the urea-releasing lyase equation; the primary study notes glyoxylate hydration in solution and does not experimentally exclude water participation in the elementary mechanism.	"[{""reference_id"": ""RHEA:11304"", ""source_assertion"": ""RHEA:11305 products contain CHEBI:36655 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/11305 rh:products; http://rdf.rhea-db.org/11304_R rh:contains1 http://rdf.rhea-db.org/Participant_11304_compound_3124; http://rdf.rhea-db.org/Participant_11304_compound_3124 rh:compound http://rdf.rhea-db.org/Compound_3124; http://rdf.rhea-db.org/Compound_3124 rh:accession""}]"	"[{""id"": ""RHEA:11304"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 11304 reaction family; selected 11305"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-018_3833e31a378c	RHEA:17030	BFO:0000050	MetaCyc:PWY-5705	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ALLANTOINASE-RXN|MetaCyc:PWY-5698|MetaCyc:PWY-5705|RHEA:17029|UniProtKB:P77671	Membership in the complete four-step native glyoxylate branch, with the exact selected Rhea direction.	"[{""reference_id"": ""MetaCyc:PWY-5705"", ""source_assertion"": ""PWY-5705 contains the PWY-5698 subpathway followed by UREIDOGLYCOLATE-LYASE-RXN, forming the native route to glyoxylate."", ""source_locator"": ""Pathway/reaction-list; Pathway/sub-pathways; Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:PWY-5698"", ""source_assertion"": ""PWY-5698 explicitly contains ALLANTOINASE-RXN in its three-step reaction list."", ""source_locator"": ""Pathway/reaction-list; Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:ALLANTOINASE-RXN"", ""source_assertion"": ""The native reaction has Rhea cross-reference 17030."", ""source_locator"": ""Reaction/dblink[dblink-db=RHEA]/dblink-oid""}, {""reference_id"": ""UniProtKB:P77671"", ""source_assertion"": ""The reviewed protein catalytic-activity entry identifies RHEA:17029; this grounds the current reaction-family choice."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences[database=Rhea]""}, {""reference_id"": ""RHEA:17029"", ""source_assertion"": ""RHEA:17029 rh:directionalReaction includes RHEA:17030, whose substrates and products define the selected left-to-right reaction."", ""source_locator"": ""http://rdf.rhea-db.org/17029 rh:directionalReaction http://rdf.rhea-db.org/17030; http://rdf.rhea-db.org/17030 rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:ALLANTOINASE-RXN"", ""source_sha256"": ""ffde639061cf1091bc7e1b70dab1bc42217e3fb47dd85382e48a4581e802fdf2"", ""source_version"": ""22.5; complete native XML; retrieved or digest-verified 2026-10-11 UTC"", ""title"": ""MetaCyc ALLANTOINASE-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ALLANTOINASE-RXN""}, {""id"": ""MetaCyc:PWY-5698"", ""source_sha256"": ""a89a140f3dc86e1e05cc22c7cd90fed3cd3e20cfe15ad041961fa6a6c45a4071"", ""source_version"": ""22.5; complete native XML; retrieved or digest-verified 2026-10-11 UTC"", ""title"": ""MetaCyc PWY-5698"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5698""}, {""id"": ""MetaCyc:PWY-5705"", ""source_sha256"": ""e13b689bbcc88cc5521fcb520d0ea8c4471f24aed4d38da236948686c1f692e4"", ""source_version"": ""22.5; complete native XML; retrieved or digest-verified 2026-10-11 UTC"", ""title"": ""MetaCyc PWY-5705"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5705""}, {""id"": ""RHEA:17029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 17029 reaction family; selected 17030"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P77671"", ""source_sha256"": ""d506ba7a7bd21613ad6dbdc1bd67b1dfeb06d55ac7558ece69ca48ca6cc39fd8"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P77671"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77671.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-019_05c2b9a6f6d5	RHEA:27486	BFO:0000050	MetaCyc:PWY-5705	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ALLANTOATE-DEIMINASE-RXN|MetaCyc:PWY-5698|MetaCyc:PWY-5705|RHEA:27485|UniProtKB:P77425	Membership in the complete four-step native glyoxylate branch, with the exact selected Rhea direction. The native 13594 cross-reference is stale; current AllC annotation and matched native chemistry ground the 27485 family without treating 13594 as a current exact match.	"[{""reference_id"": ""MetaCyc:PWY-5705"", ""source_assertion"": ""PWY-5705 contains the PWY-5698 subpathway followed by UREIDOGLYCOLATE-LYASE-RXN, forming the native route to glyoxylate."", ""source_locator"": ""Pathway/reaction-list; Pathway/sub-pathways; Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:PWY-5698"", ""source_assertion"": ""PWY-5698 explicitly contains ALLANTOATE-DEIMINASE-RXN in its three-step reaction list."", ""source_locator"": ""Pathway/reaction-list; Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:ALLANTOATE-DEIMINASE-RXN"", ""source_assertion"": ""The native allantoate deiminase reaction forms ureidoglycine, ammonium and carbon dioxide; its legacy Rhea cross-reference is 13594."", ""source_locator"": ""Reaction/left; Reaction/right; Reaction/dblink[dblink-db=RHEA]""}, {""reference_id"": ""UniProtKB:P77425"", ""source_assertion"": ""The reviewed protein catalytic-activity entry identifies RHEA:27485; this grounds the current reaction-family choice."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences[database=Rhea]""}, {""reference_id"": ""RHEA:27485"", ""source_assertion"": ""RHEA:27485 rh:directionalReaction includes RHEA:27486, whose substrates and products define the selected left-to-right reaction."", ""source_locator"": ""http://rdf.rhea-db.org/27485 rh:directionalReaction http://rdf.rhea-db.org/27486; http://rdf.rhea-db.org/27486 rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:ALLANTOATE-DEIMINASE-RXN"", ""source_sha256"": ""508bed1d9de239993214c5e6d32a3e73e4396aad76a0202d7e088eac35d10300"", ""source_version"": ""22.5; complete native XML; retrieved or digest-verified 2026-10-11 UTC"", ""title"": ""MetaCyc ALLANTOATE-DEIMINASE-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ALLANTOATE-DEIMINASE-RXN""}, {""id"": ""MetaCyc:PWY-5698"", ""source_sha256"": ""a89a140f3dc86e1e05cc22c7cd90fed3cd3e20cfe15ad041961fa6a6c45a4071"", ""source_version"": ""22.5; complete native XML; retrieved or digest-verified 2026-10-11 UTC"", ""title"": ""MetaCyc PWY-5698"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5698""}, {""id"": ""MetaCyc:PWY-5705"", ""source_sha256"": ""e13b689bbcc88cc5521fcb520d0ea8c4471f24aed4d38da236948686c1f692e4"", ""source_version"": ""22.5; complete native XML; retrieved or digest-verified 2026-10-11 UTC"", ""title"": ""MetaCyc PWY-5705"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5705""}, {""id"": ""RHEA:27485"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 27485 reaction family; selected 27486"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P77425"", ""source_sha256"": ""880e9d42e786beb498bf8e2e71c59fb0e4c769e06423a5ba3d15594ee0827907"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P77425"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77425.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-020_4f9f22268641	RHEA:25242	BFO:0000050	MetaCyc:PWY-5705	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5698|MetaCyc:PWY-5705|MetaCyc:URUR-RXN|RHEA:25241|UniProtKB:P75713	Membership in the complete four-step native glyoxylate branch, with the exact selected Rhea direction.	"[{""reference_id"": ""MetaCyc:PWY-5705"", ""source_assertion"": ""PWY-5705 contains the PWY-5698 subpathway followed by UREIDOGLYCOLATE-LYASE-RXN, forming the native route to glyoxylate."", ""source_locator"": ""Pathway/reaction-list; Pathway/sub-pathways; Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:PWY-5698"", ""source_assertion"": ""PWY-5698 explicitly contains URUR-RXN in its three-step reaction list."", ""source_locator"": ""Pathway/reaction-list; Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:URUR-RXN"", ""source_assertion"": ""The native reaction has Rhea cross-reference 25242."", ""source_locator"": ""Reaction/dblink[dblink-db=RHEA]/dblink-oid""}, {""reference_id"": ""UniProtKB:P75713"", ""source_assertion"": ""The reviewed protein catalytic-activity entry identifies RHEA:25241; this grounds the current reaction-family choice."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences[database=Rhea]""}, {""reference_id"": ""RHEA:25241"", ""source_assertion"": ""RHEA:25241 rh:directionalReaction includes RHEA:25242, whose substrates and products define the selected left-to-right reaction."", ""source_locator"": ""http://rdf.rhea-db.org/25241 rh:directionalReaction http://rdf.rhea-db.org/25242; http://rdf.rhea-db.org/25242 rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5698"", ""source_sha256"": ""a89a140f3dc86e1e05cc22c7cd90fed3cd3e20cfe15ad041961fa6a6c45a4071"", ""source_version"": ""22.5; complete native XML; retrieved or digest-verified 2026-10-11 UTC"", ""title"": ""MetaCyc PWY-5698"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5698""}, {""id"": ""MetaCyc:PWY-5705"", ""source_sha256"": ""e13b689bbcc88cc5521fcb520d0ea8c4471f24aed4d38da236948686c1f692e4"", ""source_version"": ""22.5; complete native XML; retrieved or digest-verified 2026-10-11 UTC"", ""title"": ""MetaCyc PWY-5705"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5705""}, {""id"": ""MetaCyc:URUR-RXN"", ""source_sha256"": ""8aae4d1274bd5fe140d9f6678e153ffce7ca59d8ca777c9e2122f50c5bbde746"", ""source_version"": ""22.5; complete native XML; retrieved or digest-verified 2026-10-11 UTC"", ""title"": ""MetaCyc URUR-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:URUR-RXN""}, {""id"": ""RHEA:25241"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 25241 reaction family; selected 25242"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P75713"", ""source_sha256"": ""157e35398d7aa8c6c0962b8b39458433bbc82489b78df0b9ce316183042cac5a"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P75713"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75713.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-021_513d03988ded	RHEA:11305	BFO:0000050	MetaCyc:PWY-5705	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5705|MetaCyc:UREIDOGLYCOLATE-LYASE-RXN|RHEA:11304|UniProtKB:P77731	Membership in the complete four-step native glyoxylate branch, with the exact selected Rhea direction.	"[{""reference_id"": ""MetaCyc:PWY-5705"", ""source_assertion"": ""PWY-5705 contains the PWY-5698 subpathway followed by UREIDOGLYCOLATE-LYASE-RXN, forming the native route to glyoxylate."", ""source_locator"": ""Pathway/reaction-list; Pathway/sub-pathways; Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:UREIDOGLYCOLATE-LYASE-RXN"", ""source_assertion"": ""The native reaction has Rhea cross-reference 11305."", ""source_locator"": ""Reaction/dblink[dblink-db=RHEA]/dblink-oid""}, {""reference_id"": ""UniProtKB:P77731"", ""source_assertion"": ""The reviewed protein catalytic-activity entry identifies RHEA:11304; this grounds the current reaction-family choice."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences[database=Rhea]""}, {""reference_id"": ""RHEA:11304"", ""source_assertion"": ""RHEA:11304 rh:directionalReaction includes RHEA:11305, whose substrates and products define the selected left-to-right reaction."", ""source_locator"": ""http://rdf.rhea-db.org/11304 rh:directionalReaction http://rdf.rhea-db.org/11305; http://rdf.rhea-db.org/11305 rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5705"", ""source_sha256"": ""e13b689bbcc88cc5521fcb520d0ea8c4471f24aed4d38da236948686c1f692e4"", ""source_version"": ""22.5; complete native XML; retrieved or digest-verified 2026-10-11 UTC"", ""title"": ""MetaCyc PWY-5705"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5705""}, {""id"": ""MetaCyc:UREIDOGLYCOLATE-LYASE-RXN"", ""source_sha256"": ""f9ee1d3c5715ece0c58b1b5c25bafd5efc14e072f9a33b670c238b064af47782"", ""source_version"": ""22.5; complete native XML; retrieved or digest-verified 2026-10-11 UTC"", ""title"": ""MetaCyc UREIDOGLYCOLATE-LYASE-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:UREIDOGLYCOLATE-LYASE-RXN""}, {""id"": ""RHEA:11304"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 11304 reaction family; selected 11305"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P77731"", ""source_sha256"": ""7670311224e3e977c9c105616079708ea3d71f9a0aab3a69c280df97090c41e6"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P77731"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77731.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-022_cc0073d44f6c	UniProtKB:P77671	BFO:0000050	MetaCyc:CPLX-64	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-64|PMID:11092864|UniProtKB:P77671	The native assembly contains 4 copies of the P77671 subunit; no isolated-subunit catalysis is assigned.	"[{""reference_id"": ""MetaCyc:CPLX-64"", ""source_assertion"": ""The native Protein/component contains 4 copies of G6281-MONOMER."", ""source_locator"": ""Protein/component/Protein; Protein/component/coefficient""}, {""reference_id"": ""UniProtKB:P77671"", ""source_assertion"": ""The SUBUNIT annotation is homotetramer (ECO:0000269); the BioCyc cross-reference identifies the corresponding native monomer."", ""source_locator"": ""comments[6] SUBUNIT; uniProtKBCrossReferences[database=BioCyc]""}, {""reference_id"": ""PMID:11092864"", ""source_assertion"": ""Purified AllB gel filtration and chemical cross-linking support a homotetramer."", ""source_locator"": ""Results, molecular mass and cross-linking; Figure 4""}]"	"[{""id"": ""MetaCyc:CPLX-64"", ""source_sha256"": ""77ce25b4f49e54caa1b24ea6d316fade6124713adc17cbc0371a52ca62bbbf44"", ""source_version"": ""22.5; complete native XML; retrieved or digest-verified 2026-10-11 UTC"", ""title"": ""MetaCyc CPLX-64"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-64""}, {""id"": ""PMID:11092864"", ""source_sha256"": ""2f4e068944272532911d29449d7a133e5b995b1db7fa27984219f82364fb8304"", ""source_version"": ""Full primary article HTML; preserved original response rehashed 2026-10-11 UTC"", ""title"": ""Functional expression and characterization of the two cyclic amidohydrolase enzymes, allantoinase and a novel phenylhydantoinase, from Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC94829/""}, {""id"": ""UniProtKB:P77671"", ""source_sha256"": ""d506ba7a7bd21613ad6dbdc1bd67b1dfeb06d55ac7558ece69ca48ca6cc39fd8"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P77671"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77671.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-023_649345e10256	UniProtKB:P77425	BFO:0000050	MetaCyc:CPLX-7524	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7524|PMID:17362992|UniProtKB:P77425	The native assembly contains 2 copies of the P77425 subunit; no isolated-subunit catalysis is assigned.	"[{""reference_id"": ""MetaCyc:CPLX-7524"", ""source_assertion"": ""The native Protein/component contains 2 copies of G6285-MONOMER."", ""source_locator"": ""Protein/component/Protein; Protein/component/coefficient""}, {""reference_id"": ""UniProtKB:P77425"", ""source_assertion"": ""The SUBUNIT annotation is homodimer (ECO:0000269); the BioCyc cross-reference identifies the corresponding native monomer."", ""source_locator"": ""comments[6] SUBUNIT; uniProtKBCrossReferences[database=BioCyc]""}, {""reference_id"": ""PMID:17362992"", ""source_assertion"": ""The AllC structural abstract describes a dimerization domain and the binuclear zinc active center."", ""source_locator"": ""resultList.result[id=17362992].abstractText""}]"	"[{""id"": ""MetaCyc:CPLX-7524"", ""source_sha256"": ""4bcbfbc55456c65eb5dd44811a3028b7124cf4ecc12c5424e6a9f4d1fd5e3cde"", ""source_version"": ""22.5; complete native XML; retrieved or digest-verified 2026-10-11 UTC"", ""title"": ""MetaCyc CPLX-7524"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7524""}, {""id"": ""PMID:17362992"", ""source_sha256"": ""8752189e192ffec0125e1750211c19a9973e72313c508ffd76811bb5b1345a29"", ""source_version"": ""Indexed primary abstract only; complete retained multi-publication core JSON body digest; rehashed 2026-10-11 UTC"", ""title"": ""Structural analysis of a ternary complex of allantoate amidohydrolase from Escherichia coli reveals its mechanics."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A%2811092864%20OR%2012486048%20OR%2017362992%20OR%2025020232%20OR%2020038185%20OR%2019935661%29&format=json&resultType=core&pageSize=20""}, {""id"": ""UniProtKB:P77425"", ""source_sha256"": ""880e9d42e786beb498bf8e2e71c59fb0e4c769e06423a5ba3d15594ee0827907"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P77425"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77425.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-024_68ec3b822cd9	MetaCyc:CPLX-64	pathwaymech:catalyzes	RHEA:17030	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-64|PMID:11092864|PMID:12486048|UniProtKB:P77671	Purified E. coli AllB hydrolyzes S-allantoin. The native homotetramer is the catalyst; cobalt-substituted preparations also turn over R-allantoin more slowly, outside this S-specific route.	"[{""reference_id"": ""UniProtKB:P77671"", ""source_assertion"": ""Catalytic activity assigns RHEA:17029 with experimental evidence from PMID:11092864."", ""source_locator"": ""comments[1].reaction; comments[1].reaction.evidences""}, {""reference_id"": ""MetaCyc:CPLX-64"", ""source_assertion"": ""The complex catalyzes ENZRXN0-268, whose reaction is ALLANTOINASE-RXN."", ""source_locator"": ""Protein/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""PMID:11092864"", ""source_assertion"": ""The purified AllB protein has allantoinase activity and tetrameric molecular size."", ""source_locator"": ""Results, purification and molecular mass determination; Figures 3B and 4""}, {""reference_id"": ""PMID:12486048"", ""source_assertion"": ""The zinc enzyme consumes S-allantoin; cobalt preparations prefer S but also turn over R at about one tenth the rate."", ""source_locator"": ""Results, Enantioselectivity; Figure 6""}]"	"[{""id"": ""MetaCyc:CPLX-64"", ""source_sha256"": ""77ce25b4f49e54caa1b24ea6d316fade6124713adc17cbc0371a52ca62bbbf44"", ""source_version"": ""22.5; complete native XML; retrieved or digest-verified 2026-10-11 UTC"", ""title"": ""MetaCyc CPLX-64"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-64""}, {""id"": ""PMID:11092864"", ""source_sha256"": ""2f4e068944272532911d29449d7a133e5b995b1db7fa27984219f82364fb8304"", ""source_version"": ""Full primary article HTML; preserved original response rehashed 2026-10-11 UTC"", ""title"": ""Functional expression and characterization of the two cyclic amidohydrolase enzymes, allantoinase and a novel phenylhydantoinase, from Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC94829/""}, {""id"": ""PMID:12486048"", ""source_sha256"": ""b10a113c20794a750b2c58a1fdae1278800153b085f1d18b329f258b0b0665b4"", ""source_version"": ""Full primary article HTML; preserved original response rehashed 2026-10-11 UTC"", ""title"": ""Metal ion dependence of recombinant Escherichia coli allantoinase."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC141845/""}, {""id"": ""UniProtKB:P77671"", ""source_sha256"": ""d506ba7a7bd21613ad6dbdc1bd67b1dfeb06d55ac7558ece69ca48ca6cc39fd8"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P77671"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77671.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-025_2286dc8c8b1c	MetaCyc:CPLX-7524	pathwaymech:catalyzes	RHEA:27486	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7524|PMID:20038185|UniProtKB:P77425	AllC generates S-ureidoglycine; it does not replace the distinct AllE step. The earlier structural paper described a combined downstream product, corrected by the later product-identification study.	"[{""reference_id"": ""UniProtKB:P77425"", ""source_assertion"": ""AllC catalytic activity is RHEA:27485 with experimental evidence PMID:20038185."", ""source_locator"": ""comments[1].reaction; comments[1].reaction.evidences""}, {""reference_id"": ""MetaCyc:CPLX-7524"", ""source_assertion"": ""The complex catalyzes ENZRXN-323, whose reaction is ALLANTOATE-DEIMINASE-RXN."", ""source_locator"": ""Protein/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""PMID:20038185"", ""source_assertion"": ""NMR identifies S-ureidoglycine as the true AAH product; the bacterial AllE protein performs a separate manganese-dependent hydrolysis."", ""source_locator"": ""resultList.result[id=20038185].abstractText""}]"	"[{""id"": ""MetaCyc:CPLX-7524"", ""source_sha256"": ""4bcbfbc55456c65eb5dd44811a3028b7124cf4ecc12c5424e6a9f4d1fd5e3cde"", ""source_version"": ""22.5; complete native XML; retrieved or digest-verified 2026-10-11 UTC"", ""title"": ""MetaCyc CPLX-7524"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7524""}, {""id"": ""PMID:20038185"", ""source_sha256"": ""8752189e192ffec0125e1750211c19a9973e72313c508ffd76811bb5b1345a29"", ""source_version"": ""Indexed primary abstract only; complete retained multi-publication core JSON body digest; rehashed 2026-10-11 UTC"", ""title"": ""Chemical basis of nitrogen recovery through the ureide pathway: formation and hydrolysis of S-ureidoglycine in plants and bacteria."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A%2811092864%20OR%2012486048%20OR%2017362992%20OR%2025020232%20OR%2020038185%20OR%2019935661%29&format=json&resultType=core&pageSize=20""}, {""id"": ""UniProtKB:P77425"", ""source_sha256"": ""880e9d42e786beb498bf8e2e71c59fb0e4c769e06423a5ba3d15594ee0827907"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P77425"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77425.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-026_72cc6c35bf34	UniProtKB:P75713	pathwaymech:catalyzes	RHEA:25242	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:20038185|UniProtKB:P75713	AllE hydrolyzes S-ureidoglycine to S-ureidoglycolate and ammonium. Its monomer assignment is curator inference; it is not upgraded to an experimentally measured oligomeric state.	"[{""reference_id"": ""UniProtKB:P75713"", ""source_assertion"": ""Catalytic activity assigns RHEA:25241 with experimental PMID:19935661 and curator-inference PMID:20038185 evidence; the monomer annotation is ECO:0000305."", ""source_locator"": ""comments[1].reaction; comments[3] SUBUNIT""}, {""reference_id"": ""PMID:20038185"", ""source_assertion"": ""E. coli YlbA catalyzes manganese-dependent hydrolysis of S-ureidoglycine, yielding S-ureidoglycolate with configurational inversion."", ""source_locator"": ""resultList.result[id=20038185].abstractText""}]"	"[{""id"": ""PMID:20038185"", ""source_sha256"": ""8752189e192ffec0125e1750211c19a9973e72313c508ffd76811bb5b1345a29"", ""source_version"": ""Indexed primary abstract only; complete retained multi-publication core JSON body digest; rehashed 2026-10-11 UTC"", ""title"": ""Chemical basis of nitrogen recovery through the ureide pathway: formation and hydrolysis of S-ureidoglycine in plants and bacteria."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A%2811092864%20OR%2012486048%20OR%2017362992%20OR%2025020232%20OR%2020038185%20OR%2019935661%29&format=json&resultType=core&pageSize=20""}, {""id"": ""UniProtKB:P75713"", ""source_sha256"": ""157e35398d7aa8c6c0962b8b39458433bbc82489b78df0b9ce316183042cac5a"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P75713"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75713.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-027_deb28547c7ec	UniProtKB:P77731	pathwaymech:enables	RHEA:11305	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:10601204|PMID:24107613|UniProtKB:P77731	AllA supplies the experimentally demonstrated urea-releasing activity. Current structural annotation describes a homodimer; this gene-product role does not assert that an isolated subunit suffices. Older ammonia-releasing hydrolase annotations are rejected.	"[{""reference_id"": ""UniProtKB:P77731"", ""source_assertion"": ""Catalytic activity assigns RHEA:11304 with experimental PMID:24107613 evidence. SUBUNIT is homodimer, supported by structural submission Ref.6 and HAMAP inference."", ""source_locator"": ""comments[1].reaction; comments[4] SUBUNIT; references[citation.id=CI-4ICJD7CSP0B6L]""}, {""reference_id"": ""PMID:24107613"", ""source_assertion"": ""Recombinant E. coli AllA releases urea, detected as ammonia only after urease addition; the expressed clone is JW0493."", ""source_locator"": ""Results and discussion, Nickel-dependent urea-release activity of AllA; Figure 2A-B; Methods, Biochemistry""}, {""reference_id"": ""PMID:10601204"", ""source_assertion"": ""allA disruption abolishes ureidoglycolate-cleaving activity but does not impair growth on xylose-allantoin medium."", ""source_locator"": ""HTML section#sec13, allA disruption and JA174 growth paragraph""}]"	"[{""id"": ""PMID:10601204"", ""source_sha256"": ""a8fdc4fde9bbbb25a906b2f84c34a5cfa72914a2ffa8afcdfc066e5604a19350"", ""source_version"": ""Full primary article HTML; retrieved 2026-10-11 UTC"", ""title"": ""Genetic Analysis of a Chromosomal Region Containing Genes Required for Assimilation of Allantoin Nitrogen and Linked Glyoxylate Metabolism in Escherichia coli"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC94204/""}, {""id"": ""PMID:24107613"", ""source_sha256"": ""856f106774e34dca4bbfde4bc74c741c9f461ff9b23686ad5a9a2510e22a7a4d"", ""source_version"": ""Full primary article XML; retrieved 2026-10-11 UTC"", ""title"": ""Ureidoglycolate hydrolase, amidohydrolase, lyase: how errors in biological databases are incorporated in scientific papers and vice versa"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3793230/fullTextXML""}, {""id"": ""UniProtKB:P77731"", ""source_sha256"": ""7670311224e3e977c9c105616079708ea3d71f9a0aab3a69c280df97090c41e6"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P77731"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77731.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-028_6c91ae5c99d7	MetaCyc:CPLX-64	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12486048|UniProtKB:P77671	Alternative AllB metal preparation, not a simultaneous four-metal requirement. Zinc is favored as the physiological metal in the 2003 study; alternative activity and occupancy depend on preparation.	"[{""reference_id"": ""UniProtKB:P77671"", ""source_assertion"": ""AllB is annotated to use zinc and alternatively nickel, cobalt or manganese; this combines ECO:0000269 and ECO:0000305 evidence."", ""source_locator"": ""comments[2] COFACTOR; cofactors; note""}, {""reference_id"": ""PMID:12486048"", ""source_assertion"": ""Metal-substituted preparations show different occupancy, activity and stereoselectivity; nickel and cobalt substitution does not establish their physiological necessity."", ""source_locator"": ""Abstract; Results, metal content; Discussion""}]"	"[{""id"": ""PMID:12486048"", ""source_sha256"": ""b10a113c20794a750b2c58a1fdae1278800153b085f1d18b329f258b0b0665b4"", ""source_version"": ""Full primary article HTML; preserved original response rehashed 2026-10-11 UTC"", ""title"": ""Metal ion dependence of recombinant Escherichia coli allantoinase."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC141845/""}, {""id"": ""UniProtKB:P77671"", ""source_sha256"": ""d506ba7a7bd21613ad6dbdc1bd67b1dfeb06d55ac7558ece69ca48ca6cc39fd8"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P77671"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77671.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-029_2524a01edd48	MetaCyc:CPLX-64	pathwaymech:has_cofactor	CHEBI:49786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12486048|UniProtKB:P77671	Alternative AllB metal preparation, not a simultaneous four-metal requirement. Zinc is favored as the physiological metal in the 2003 study; alternative activity and occupancy depend on preparation.	"[{""reference_id"": ""UniProtKB:P77671"", ""source_assertion"": ""AllB is annotated to use zinc and alternatively nickel, cobalt or manganese; this combines ECO:0000269 and ECO:0000305 evidence."", ""source_locator"": ""comments[2] COFACTOR; cofactors; note""}, {""reference_id"": ""PMID:12486048"", ""source_assertion"": ""Metal-substituted preparations show different occupancy, activity and stereoselectivity; nickel and cobalt substitution does not establish their physiological necessity."", ""source_locator"": ""Abstract; Results, metal content; Discussion""}]"	"[{""id"": ""PMID:12486048"", ""source_sha256"": ""b10a113c20794a750b2c58a1fdae1278800153b085f1d18b329f258b0b0665b4"", ""source_version"": ""Full primary article HTML; preserved original response rehashed 2026-10-11 UTC"", ""title"": ""Metal ion dependence of recombinant Escherichia coli allantoinase."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC141845/""}, {""id"": ""UniProtKB:P77671"", ""source_sha256"": ""d506ba7a7bd21613ad6dbdc1bd67b1dfeb06d55ac7558ece69ca48ca6cc39fd8"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P77671"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77671.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-030_caa1caf0039c	MetaCyc:CPLX-64	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12486048|UniProtKB:P77671	Alternative AllB metal preparation, not a simultaneous four-metal requirement. Zinc is favored as the physiological metal in the 2003 study; alternative activity and occupancy depend on preparation.	"[{""reference_id"": ""UniProtKB:P77671"", ""source_assertion"": ""AllB is annotated to use zinc and alternatively nickel, cobalt or manganese; this combines ECO:0000269 and ECO:0000305 evidence."", ""source_locator"": ""comments[2] COFACTOR; cofactors; note""}, {""reference_id"": ""PMID:12486048"", ""source_assertion"": ""Metal-substituted preparations show different occupancy, activity and stereoselectivity; nickel and cobalt substitution does not establish their physiological necessity."", ""source_locator"": ""Abstract; Results, metal content; Discussion""}]"	"[{""id"": ""PMID:12486048"", ""source_sha256"": ""b10a113c20794a750b2c58a1fdae1278800153b085f1d18b329f258b0b0665b4"", ""source_version"": ""Full primary article HTML; preserved original response rehashed 2026-10-11 UTC"", ""title"": ""Metal ion dependence of recombinant Escherichia coli allantoinase."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC141845/""}, {""id"": ""UniProtKB:P77671"", ""source_sha256"": ""d506ba7a7bd21613ad6dbdc1bd67b1dfeb06d55ac7558ece69ca48ca6cc39fd8"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P77671"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77671.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-031_682ceaccaff5	MetaCyc:CPLX-64	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77671	Alternative AllB metal preparation, not a simultaneous four-metal requirement. Zinc is favored as the physiological metal in the 2003 study; alternative activity and occupancy depend on preparation.	"[{""reference_id"": ""UniProtKB:P77671"", ""source_assertion"": ""AllB is annotated to use zinc and alternatively nickel, cobalt or manganese; this combines ECO:0000269 and ECO:0000305 evidence."", ""source_locator"": ""comments[2] COFACTOR; cofactors; note""}]"	"[{""id"": ""UniProtKB:P77671"", ""source_sha256"": ""d506ba7a7bd21613ad6dbdc1bd67b1dfeb06d55ac7558ece69ca48ca6cc39fd8"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P77671"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77671.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-032_b9332157624b	MetaCyc:CPLX-7524	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:17362992|UniProtKB:P77425	Two bound zinc ions per AllC subunit are reported in the earlier structure; this does not make zinc the unique physiological metal.	"[{""reference_id"": ""UniProtKB:P77425"", ""source_assertion"": ""AllC binds two Zn2+ ions per subunit, with experimental evidence PMID:17362992."", ""source_locator"": ""comments[2] COFACTOR; note""}, {""reference_id"": ""PMID:17362992"", ""source_assertion"": ""The active center contains two co-catalytic zinc ions."", ""source_locator"": ""resultList.result[id=17362992].abstractText""}]"	"[{""id"": ""PMID:17362992"", ""source_sha256"": ""8752189e192ffec0125e1750211c19a9973e72313c508ffd76811bb5b1345a29"", ""source_version"": ""Indexed primary abstract only; complete retained multi-publication core JSON body digest; rehashed 2026-10-11 UTC"", ""title"": ""Structural analysis of a ternary complex of allantoate amidohydrolase from Escherichia coli reveals its mechanics."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A%2811092864%20OR%2012486048%20OR%2017362992%20OR%2025020232%20OR%2020038185%20OR%2019935661%29&format=json&resultType=core&pageSize=20""}, {""id"": ""UniProtKB:P77425"", ""source_sha256"": ""880e9d42e786beb498bf8e2e71c59fb0e4c769e06423a5ba3d15594ee0827907"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P77425"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77425.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-033_2d52a883b6c3	MetaCyc:CPLX-7524	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:20038185|UniProtKB:P77425	AllC also binds manganese, and its functional manganese dependence is supported separately from the earlier zinc structure.	"[{""reference_id"": ""UniProtKB:P77425"", ""source_assertion"": ""AllC is also able to bind Mn2+, with experimental evidence PMID:25020232."", ""source_locator"": ""comments[2].note""}, {""reference_id"": ""PMID:20038185"", ""source_assertion"": ""Allantoate amidohydrolase is described as a manganese-dependent enzyme found in plants and bacteria."", ""source_locator"": ""resultList.result[id=20038185].abstractText""}]"	"[{""id"": ""PMID:20038185"", ""source_sha256"": ""8752189e192ffec0125e1750211c19a9973e72313c508ffd76811bb5b1345a29"", ""source_version"": ""Indexed primary abstract only; complete retained multi-publication core JSON body digest; rehashed 2026-10-11 UTC"", ""title"": ""Chemical basis of nitrogen recovery through the ureide pathway: formation and hydrolysis of S-ureidoglycine in plants and bacteria."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A%2811092864%20OR%2012486048%20OR%2017362992%20OR%2025020232%20OR%2020038185%20OR%2019935661%29&format=json&resultType=core&pageSize=20""}, {""id"": ""UniProtKB:P77425"", ""source_sha256"": ""880e9d42e786beb498bf8e2e71c59fb0e4c769e06423a5ba3d15594ee0827907"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P77425"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77425.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-034_df8e07ce61cd	UniProtKB:P75713	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P75713	Manganese and cobalt support alternative AllE preparations; they are not simultaneous requirements.	"[{""reference_id"": ""UniProtKB:P75713"", ""source_assertion"": ""AllE uses Mn2+ and can also use Co2+, supported by ECO:0000269 from PMID:20038185."", ""source_locator"": ""comments[2] COFACTOR; note""}]"	"[{""id"": ""UniProtKB:P75713"", ""source_sha256"": ""157e35398d7aa8c6c0962b8b39458433bbc82489b78df0b9ce316183042cac5a"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P75713"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75713.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-035_4705826ac6ae	UniProtKB:P75713	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P75713	Manganese and cobalt support alternative AllE preparations; they are not simultaneous requirements.	"[{""reference_id"": ""UniProtKB:P75713"", ""source_assertion"": ""AllE uses Mn2+ and can also use Co2+, supported by ECO:0000269 from PMID:20038185."", ""source_locator"": ""comments[2] COFACTOR; note""}]"	"[{""id"": ""UniProtKB:P75713"", ""source_sha256"": ""157e35398d7aa8c6c0962b8b39458433bbc82489b78df0b9ce316183042cac5a"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P75713"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75713.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-036_d89385118408	UniProtKB:P77731	pathwaymech:has_cofactor	CHEBI:49786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:24107613|UniProtKB:P77731	AllA urea-release activity is nickel dependent in the purified-protein experiment. This protein-level relation does not resolve metal occupancy per protomer or imply isolated-subunit catalysis.	"[{""reference_id"": ""UniProtKB:P77731"", ""source_assertion"": ""Ni2+ is the annotated AllA cofactor, with experimental PMID:24107613 and HAMAP evidence."", ""source_locator"": ""comments[2] COFACTOR""}, {""reference_id"": ""PMID:24107613"", ""source_assertion"": ""EDTA treatment abolishes AllA urea-release activity; only Ni2+ rescues it among the tested divalent ions."", ""source_locator"": ""Results and discussion, Nickel-dependent urea-release activity of AllA; Figure 2C; Methods, Biochemistry""}]"	"[{""id"": ""PMID:24107613"", ""source_sha256"": ""856f106774e34dca4bbfde4bc74c741c9f461ff9b23686ad5a9a2510e22a7a4d"", ""source_version"": ""Full primary article XML; retrieved 2026-10-11 UTC"", ""title"": ""Ureidoglycolate hydrolase, amidohydrolase, lyase: how errors in biological databases are incorporated in scientific papers and vice versa"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3793230/fullTextXML""}, {""id"": ""UniProtKB:P77731"", ""source_sha256"": ""7670311224e3e977c9c105616079708ea3d71f9a0aab3a69c280df97090c41e6"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P77731"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77731.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-037_cdf5e5b5b3db	UniProtKB:P77425	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77425	Protein-level cytoplasmic localization at the source evidence tier; this is not propagated to the other pathway proteins.	"[{""reference_id"": ""UniProtKB:P77425"", ""source_assertion"": ""The protein is annotated in the cytoplasm with ECO:0000305; GO cross-reference IEA:UniProtKB-SubCell."", ""source_locator"": ""comments[7] SUBCELLULAR LOCATION; uniProtKBCrossReferences[database=GO,id=GO:0005737]""}]"	"[{""id"": ""UniProtKB:P77425"", ""source_sha256"": ""880e9d42e786beb498bf8e2e71c59fb0e4c769e06423a5ba3d15594ee0827907"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P77425"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77425.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-038_d5a99bdf28a3	UniProtKB:P75713	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P75713	Protein-level cytoplasmic localization at the source evidence tier; this is not propagated to the other pathway proteins.	"[{""reference_id"": ""UniProtKB:P75713"", ""source_assertion"": ""The protein is annotated in the cytoplasm with ECO:0000269; GO cross-reference EXP:UniProtKB."", ""source_locator"": ""comments[4] SUBCELLULAR LOCATION; uniProtKBCrossReferences[database=GO,id=GO:0005737]""}]"	"[{""id"": ""UniProtKB:P75713"", ""source_sha256"": ""157e35398d7aa8c6c0962b8b39458433bbc82489b78df0b9ce316183042cac5a"", ""source_version"": ""2026_03 (2026-09-02); complete response retrieved 2026-10-11 UTC"", ""title"": ""Reviewed UniProtKB P75713"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75713.json""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-039_2f39453d39c7	RHEA:17030	RO:0002413	RHEA:27486	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5698|RHEA:17029|RHEA:27485	The product CHEBI:17536 is the shared intermediate in the native ordered sequence; this states metabolite handoff, not a physical channeling complex.	"[{""reference_id"": ""MetaCyc:PWY-5698"", ""source_assertion"": ""Native reaction-ordering places ALLANTOINASE-RXN before ALLANTOATE-DEIMINASE-RXN."", ""source_locator"": ""Pathway/reaction-ordering; Pathway/reaction-layout""}, {""reference_id"": ""RHEA:17029"", ""source_assertion"": ""RHEA:17030 produces CHEBI:17536, the intermediate used by the next selected reaction."", ""source_locator"": ""http://rdf.rhea-db.org/17030 rh:products http://rdf.rhea-db.org/17029_R; http://rdf.rhea-db.org/17029_R rh:contains1 http://rdf.rhea-db.org/Participant_17029_compound_4604; rh:compound http://rdf.rhea-db.org/Compound_4604; rh:accession""}, {""reference_id"": ""RHEA:27485"", ""source_assertion"": ""RHEA:27486 consumes CHEBI:17536, matching the preceding selected reaction product."", ""source_locator"": ""http://rdf.rhea-db.org/27486 rh:substrates http://rdf.rhea-db.org/27485_L; http://rdf.rhea-db.org/27485_L rh:contains1 http://rdf.rhea-db.org/Participant_27485_compound_4604; rh:compound http://rdf.rhea-db.org/Compound_4604; rh:accession""}]"	"[{""id"": ""MetaCyc:PWY-5698"", ""source_sha256"": ""a89a140f3dc86e1e05cc22c7cd90fed3cd3e20cfe15ad041961fa6a6c45a4071"", ""source_version"": ""22.5; complete native XML; retrieved or digest-verified 2026-10-11 UTC"", ""title"": ""MetaCyc PWY-5698"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5698""}, {""id"": ""RHEA:17029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 17029 reaction family; selected 17030"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:27485"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 27485 reaction family; selected 27486"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-040_5dd84278ccf5	RHEA:27486	RO:0002413	RHEA:25242	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5698|RHEA:25241|RHEA:27485	The product CHEBI:59947 is the shared intermediate in the native ordered sequence; this states metabolite handoff, not a physical channeling complex.	"[{""reference_id"": ""MetaCyc:PWY-5698"", ""source_assertion"": ""Native reaction-ordering places ALLANTOATE-DEIMINASE-RXN before URUR-RXN."", ""source_locator"": ""Pathway/reaction-ordering; Pathway/reaction-layout""}, {""reference_id"": ""RHEA:27485"", ""source_assertion"": ""RHEA:27486 produces CHEBI:59947, the intermediate used by the next selected reaction."", ""source_locator"": ""http://rdf.rhea-db.org/27486 rh:products http://rdf.rhea-db.org/27485_R; http://rdf.rhea-db.org/27485_R rh:contains1 http://rdf.rhea-db.org/Participant_27485_compound_6148; rh:compound http://rdf.rhea-db.org/Compound_6148; rh:accession""}, {""reference_id"": ""RHEA:25241"", ""source_assertion"": ""RHEA:25242 consumes CHEBI:59947, matching the preceding selected reaction product."", ""source_locator"": ""http://rdf.rhea-db.org/25242 rh:substrates http://rdf.rhea-db.org/25241_L; http://rdf.rhea-db.org/25241_L rh:contains1 http://rdf.rhea-db.org/Participant_25241_compound_6148; rh:compound http://rdf.rhea-db.org/Compound_6148; rh:accession""}]"	"[{""id"": ""MetaCyc:PWY-5698"", ""source_sha256"": ""a89a140f3dc86e1e05cc22c7cd90fed3cd3e20cfe15ad041961fa6a6c45a4071"", ""source_version"": ""22.5; complete native XML; retrieved or digest-verified 2026-10-11 UTC"", ""title"": ""MetaCyc PWY-5698"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5698""}, {""id"": ""RHEA:25241"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 25241 reaction family; selected 25242"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:27485"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 27485 reaction family; selected 27486"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5705_allantoin-glyoxylate-iii-edge-041_a03dfe8399ec	RHEA:25242	RO:0002413	RHEA:11305	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5705|RHEA:11304|RHEA:25241	The product CHEBI:57296 is the shared intermediate in the native ordered sequence; this states metabolite handoff, not a physical channeling complex.	"[{""reference_id"": ""MetaCyc:PWY-5705"", ""source_assertion"": ""Native reaction-ordering places URUR-RXN before UREIDOGLYCOLATE-LYASE-RXN."", ""source_locator"": ""Pathway/reaction-ordering; Pathway/reaction-layout""}, {""reference_id"": ""RHEA:25241"", ""source_assertion"": ""RHEA:25242 produces CHEBI:57296, the intermediate used by the next selected reaction."", ""source_locator"": ""http://rdf.rhea-db.org/25242 rh:products http://rdf.rhea-db.org/25241_R; http://rdf.rhea-db.org/25241_R rh:contains1 http://rdf.rhea-db.org/Participant_25241_compound_4140; rh:compound http://rdf.rhea-db.org/Compound_4140; rh:accession""}, {""reference_id"": ""RHEA:11304"", ""source_assertion"": ""RHEA:11305 consumes CHEBI:57296, matching the preceding selected reaction product."", ""source_locator"": ""http://rdf.rhea-db.org/11305 rh:substrates http://rdf.rhea-db.org/11304_L; http://rdf.rhea-db.org/11304_L rh:contains1 http://rdf.rhea-db.org/Participant_11304_compound_4140; rh:compound http://rdf.rhea-db.org/Compound_4140; rh:accession""}]"	"[{""id"": ""MetaCyc:PWY-5705"", ""source_sha256"": ""e13b689bbcc88cc5521fcb520d0ea8c4471f24aed4d38da236948686c1f692e4"", ""source_version"": ""22.5; complete native XML; retrieved or digest-verified 2026-10-11 UTC"", ""title"": ""MetaCyc PWY-5705"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5705""}, {""id"": ""RHEA:11304"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 11304 reaction family; selected 11305"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:25241"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 covers complete compressed RDF gzip"", ""title"": ""Rhea 25241 reaction family; selected 25242"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5697_edge-001_6a81dffa2eae	gomodel:ALLANTOICASE-RXN	RO:0002234	CHEBI:57296	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5697		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5697"", ""source_assertion"": ""The model asserts gomodel:ALLANTOICASE-RXN RO:0002234 gomodel:CHEBI_57296_ALLANTOICASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5697.json#/facts/0; endpoint types: /individuals/0/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY-5697.json"", ""title"": ""GO-CAM allantoin degradation to ureidoglycolate I model YeastPathways_PWY-5697"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5697_edge-002_0ff5f4e9dbf8	gomodel:ALLANTOICASE-RXN	BFO:0000050	GO:0000256	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5697		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5697"", ""source_assertion"": ""The model asserts gomodel:ALLANTOICASE-RXN BFO:0000050 gomodel:YeastPathways_PWY-5697/YeastPathways_PWY-5697."", ""source_locator"": ""./YeastPathways_PWY-5697.json#/facts/1; endpoint types: /individuals/0/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY-5697.json"", ""title"": ""GO-CAM allantoin degradation to ureidoglycolate I model YeastPathways_PWY-5697"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5697_edge-003_95d73573ca8a	gomodel:ALLANTOINASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5697		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5697"", ""source_assertion"": ""The model asserts gomodel:ALLANTOINASE-RXN RO:0002234 gomodel:CHEBI_15378_ALLANTOINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5697.json#/facts/2; endpoint types: /individuals/1/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY-5697.json"", ""title"": ""GO-CAM allantoin degradation to ureidoglycolate I model YeastPathways_PWY-5697"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5697_edge-004_f0e3f73696f1	SGD:S000001468	pathwaymech:enables	gomodel:ALLANTOICASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5697		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5697"", ""source_assertion"": ""The model asserts gomodel:ALLANTOICASE-RXN RO:0002333 gomodel:YIR029W-MONOMER_ALLANTOICASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5697.json#/facts/3; endpoint types: /individuals/0/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY-5697.json"", ""title"": ""GO-CAM allantoin degradation to ureidoglycolate I model YeastPathways_PWY-5697"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5697_edge-005_50ce998f4fb5	gomodel:ALLANTOICASE-RXN	RO:0002233	CHEBI:17536	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5697		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5697"", ""source_assertion"": ""The model asserts gomodel:ALLANTOICASE-RXN RO:0002233 gomodel:CHEBI_17536_ALLANTOINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5697.json#/facts/4; endpoint types: /individuals/0/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY-5697.json"", ""title"": ""GO-CAM allantoin degradation to ureidoglycolate I model YeastPathways_PWY-5697"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5697_edge-006_f983dff1ca6a	gomodel:ALLANTOINASE-RXN	RO:0002234	CHEBI:17536	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5697		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5697"", ""source_assertion"": ""The model asserts gomodel:ALLANTOINASE-RXN RO:0002234 gomodel:CHEBI_17536_ALLANTOINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5697.json#/facts/5; endpoint types: /individuals/1/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY-5697.json"", ""title"": ""GO-CAM allantoin degradation to ureidoglycolate I model YeastPathways_PWY-5697"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5697_edge-007_6000b1128ea5	gomodel:ALLANTOINASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5697		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5697"", ""source_assertion"": ""The model asserts gomodel:ALLANTOINASE-RXN RO:0002233 gomodel:CHEBI_15377_ALLANTOINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5697.json#/facts/6; endpoint types: /individuals/1/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY-5697.json"", ""title"": ""GO-CAM allantoin degradation to ureidoglycolate I model YeastPathways_PWY-5697"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5697_edge-008_2ac17880467d	gomodel:ALLANTOINASE-RXN	RO:0002413	gomodel:ALLANTOICASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5697		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5697"", ""source_assertion"": ""The model asserts gomodel:ALLANTOINASE-RXN RO:0002413 gomodel:ALLANTOICASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5697.json#/facts/7; endpoint types: /individuals/1/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY-5697.json"", ""title"": ""GO-CAM allantoin degradation to ureidoglycolate I model YeastPathways_PWY-5697"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5697_edge-009_0a613f543b04	gomodel:ALLANTOICASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5697		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5697"", ""source_assertion"": ""The model asserts gomodel:ALLANTOICASE-RXN RO:0002233 gomodel:CHEBI_15377_ALLANTOICASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5697.json#/facts/8; endpoint types: /individuals/0/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY-5697.json"", ""title"": ""GO-CAM allantoin degradation to ureidoglycolate I model YeastPathways_PWY-5697"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5697_edge-010_00b07c1c0691	gomodel:ALLANTOINASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5697		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5697"", ""source_assertion"": ""The model asserts gomodel:ALLANTOINASE-RXN BFO:0000066 gomodel:reaction_ALLANTOINASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5697.json#/facts/9; endpoint types: /individuals/1/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY-5697.json"", ""title"": ""GO-CAM allantoin degradation to ureidoglycolate I model YeastPathways_PWY-5697"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5697_edge-011_882af79056ec	gomodel:ALLANTOICASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5697		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5697"", ""source_assertion"": ""The model asserts gomodel:ALLANTOICASE-RXN BFO:0000066 gomodel:reaction_ALLANTOICASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5697.json#/facts/10; endpoint types: /individuals/0/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY-5697.json"", ""title"": ""GO-CAM allantoin degradation to ureidoglycolate I model YeastPathways_PWY-5697"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5697_edge-012_4347b2e7bf28	gomodel:ALLANTOINASE-RXN	BFO:0000050	GO:0000256	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5697		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5697"", ""source_assertion"": ""The model asserts gomodel:ALLANTOINASE-RXN BFO:0000050 gomodel:YeastPathways_PWY-5697/YeastPathways_PWY-5697."", ""source_locator"": ""./YeastPathways_PWY-5697.json#/facts/11; endpoint types: /individuals/1/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY-5697.json"", ""title"": ""GO-CAM allantoin degradation to ureidoglycolate I model YeastPathways_PWY-5697"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5697_edge-013_fe3477e36917	gomodel:ALLANTOINASE-RXN	RO:0002233	CHEBI:15678	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5697		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5697"", ""source_assertion"": ""The model asserts gomodel:ALLANTOINASE-RXN RO:0002233 gomodel:CHEBI_15678_ALLANTOINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5697.json#/facts/12; endpoint types: /individuals/1/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY-5697.json"", ""title"": ""GO-CAM allantoin degradation to ureidoglycolate I model YeastPathways_PWY-5697"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5697_edge-014_50e71a5c210f	SGD:S000001466	pathwaymech:enables	gomodel:ALLANTOINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5697		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5697"", ""source_assertion"": ""The model asserts gomodel:ALLANTOINASE-RXN RO:0002333 gomodel:YIR027C-MONOMER_ALLANTOINASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5697.json#/facts/13; endpoint types: /individuals/1/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY-5697.json"", ""title"": ""GO-CAM allantoin degradation to ureidoglycolate I model YeastPathways_PWY-5697"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5697_edge-015_610c4fc42915	gomodel:ALLANTOICASE-RXN	RO:0002234	CHEBI:16199	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5697		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5697"", ""source_assertion"": ""The model asserts gomodel:ALLANTOICASE-RXN RO:0002234 gomodel:CHEBI_16199_ALLANTOICASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5697.json#/facts/14; endpoint types: /individuals/0/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY-5697.json"", ""title"": ""GO-CAM allantoin degradation to ureidoglycolate I model YeastPathways_PWY-5697"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5697_cofactor-1810880c4756_0d4fe9d3cfce	SGD:S000001466	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32375	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P32375"", ""source_assertion"": ""UniProtKB:P32375 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4531/comments/0/cofactors/0; /results/4531/comments/0/note""}, {""reference_id"": ""UniProtKB:P32375"", ""source_assertion"": ""UniProtKB:P32375 has the exact SGD cross-reference SGD:S000001466."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4531/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32375"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P32375 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-001_235368c87618	MetaCyc:GLCMANNANAUT-PWY	BFO:0000051	MetaCyc:PWY0-1324	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLCMANNANAUT-PWY		"[{""reference_id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""source_assertion"": ""META 27.0 lists PWY0-1324 as a complete child pathway of this superpathway."", ""source_locator"": ""Pathway/reaction-list and Pathway/sub-pathways""}]"	"[{""id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""title"": ""MetaCyc:GLCMANNANAUT-PWY"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=GLCMANNANAUT-PWY""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-002_3b94ee58baf7	MetaCyc:GLCMANNANAUT-PWY	BFO:0000051	MetaCyc:GLUAMCAT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLCMANNANAUT-PWY		"[{""reference_id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""source_assertion"": ""META 27.0 lists GLUAMCAT-PWY as a complete child pathway of this superpathway."", ""source_locator"": ""Pathway/reaction-list and Pathway/sub-pathways""}]"	"[{""id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""title"": ""MetaCyc:GLCMANNANAUT-PWY"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=GLCMANNANAUT-PWY""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-003_d75889eed754	CHEBI:58770	pathwaymech:consumes	RHEA:67737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:67737		"[{""reference_id"": ""RHEA:67737"", ""source_assertion"": ""Rhea release 142 places CHEBI:58770 with coefficient 1 on the substrates side of RHEA:67737. Its directional object is left_to_right relative to master RHEA:67736."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/67737\""]/rh:substrates; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:67737"", ""title"": ""N-acetyl-alpha-neuraminate => aceneuramate"", ""url"": ""https://www.rhea-db.org/rhea/67737""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-004_f224651b8f58	RHEA:67737	pathwaymech:produces	CHEBI:173083	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:67737		"[{""reference_id"": ""RHEA:67737"", ""source_assertion"": ""Rhea release 142 places CHEBI:173083 with coefficient 1 on the products side of RHEA:67737. Its directional object is left_to_right relative to master RHEA:67736."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/67737\""]/rh:products; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:67737"", ""title"": ""N-acetyl-alpha-neuraminate => aceneuramate"", ""url"": ""https://www.rhea-db.org/rhea/67737""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-005_3ff049278bc7	CHEBI:58705	pathwaymech:consumes	RHEA:67741	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:67741		"[{""reference_id"": ""RHEA:67741"", ""source_assertion"": ""Rhea release 142 places CHEBI:58705 with coefficient 1 on the substrates side of RHEA:67741. Its directional object is left_to_right relative to master RHEA:67740."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/67741\""]/rh:substrates; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:67741"", ""title"": ""N-acetyl-beta-neuraminate => aceneuramate"", ""url"": ""https://www.rhea-db.org/rhea/67741""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-006_da0cf9b4ff34	RHEA:67741	pathwaymech:produces	CHEBI:173083	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:67741		"[{""reference_id"": ""RHEA:67741"", ""source_assertion"": ""Rhea release 142 places CHEBI:173083 with coefficient 1 on the products side of RHEA:67741. Its directional object is left_to_right relative to master RHEA:67740."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/67741\""]/rh:products; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:67741"", ""title"": ""N-acetyl-beta-neuraminate => aceneuramate"", ""url"": ""https://www.rhea-db.org/rhea/67741""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-007_6bcbe4d3dc8d	RHEA:67741	BFO:0000050	MetaCyc:PWY0-1324	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1324		"[{""reference_id"": ""MetaCyc:PWY0-1324"", ""source_assertion"": ""The native child includes RXN0-7389; reaction layout and corresponding Rhea sides establish this degradation direction. RXN0-7389 uses native right-to-left ring opening; NANE-RXN maps to Rhea right-to-left."", ""source_locator"": ""Pathway/reaction-list, reaction-layout and reaction-ordering""}]"	"[{""id"": ""MetaCyc:PWY0-1324"", ""title"": ""N-acetylneuraminate and N-acetylmannosamine degradation I"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=PWY0-1324""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-008_73a63851587f	CHEBI:173083	pathwaymech:consumes	RHEA:23297	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23297		"[{""reference_id"": ""RHEA:23297"", ""source_assertion"": ""Rhea release 142 places CHEBI:173083 with coefficient 1 on the substrates side of RHEA:23297. Its directional object is left_to_right relative to master RHEA:23296."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/23297\""]/rh:substrates; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23297"", ""title"": ""aceneuramate => aldehydo-N-acetyl-D-mannosamine + pyruvate"", ""url"": ""https://www.rhea-db.org/rhea/23297""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-009_8bfcbb5f62f2	RHEA:23297	pathwaymech:produces	CHEBI:17122	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23297		"[{""reference_id"": ""RHEA:23297"", ""source_assertion"": ""Rhea release 142 places CHEBI:17122 with coefficient 1 on the products side of RHEA:23297. Its directional object is left_to_right relative to master RHEA:23296."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/23297\""]/rh:products; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23297"", ""title"": ""aceneuramate => aldehydo-N-acetyl-D-mannosamine + pyruvate"", ""url"": ""https://www.rhea-db.org/rhea/23297""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-010_9c541c14d8ab	RHEA:23297	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23297		"[{""reference_id"": ""RHEA:23297"", ""source_assertion"": ""Rhea release 142 places CHEBI:15361 with coefficient 1 on the products side of RHEA:23297. Its directional object is left_to_right relative to master RHEA:23296."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/23297\""]/rh:products; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23297"", ""title"": ""aceneuramate => aldehydo-N-acetyl-D-mannosamine + pyruvate"", ""url"": ""https://www.rhea-db.org/rhea/23297""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-011_e3ffc504810b	RHEA:23297	BFO:0000050	MetaCyc:PWY0-1324	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1324		"[{""reference_id"": ""MetaCyc:PWY0-1324"", ""source_assertion"": ""The native child includes RXN0-7390; reaction layout and corresponding Rhea sides establish this degradation direction. RXN0-7389 uses native right-to-left ring opening; NANE-RXN maps to Rhea right-to-left."", ""source_locator"": ""Pathway/reaction-list, reaction-layout and reaction-ordering""}]"	"[{""id"": ""MetaCyc:PWY0-1324"", ""title"": ""N-acetylneuraminate and N-acetylmannosamine degradation I"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=PWY0-1324""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-012_6b3a53416485	CHEBI:17122	pathwaymech:consumes	RHEA:25254	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25254		"[{""reference_id"": ""RHEA:25254"", ""source_assertion"": ""Rhea release 142 places CHEBI:17122 with coefficient 1 on the substrates side of RHEA:25254. Its directional object is left_to_right relative to master RHEA:25253."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/25254\""]/rh:substrates; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25254"", ""title"": ""aldehydo-N-acetyl-D-mannosamine + ATP => aldehydo-N-acetyl-D-mannosamine 6-phosphate + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/25254""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-013_ca1e5dd7f434	CHEBI:30616	pathwaymech:consumes	RHEA:25254	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25254		"[{""reference_id"": ""RHEA:25254"", ""source_assertion"": ""Rhea release 142 places CHEBI:30616 with coefficient 1 on the substrates side of RHEA:25254. Its directional object is left_to_right relative to master RHEA:25253."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/25254\""]/rh:substrates; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25254"", ""title"": ""aldehydo-N-acetyl-D-mannosamine + ATP => aldehydo-N-acetyl-D-mannosamine 6-phosphate + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/25254""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-014_ac5a88a8d96e	RHEA:25254	pathwaymech:produces	CHEBI:58557	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25254		"[{""reference_id"": ""RHEA:25254"", ""source_assertion"": ""Rhea release 142 places CHEBI:58557 with coefficient 1 on the products side of RHEA:25254. Its directional object is left_to_right relative to master RHEA:25253."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/25254\""]/rh:products; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25254"", ""title"": ""aldehydo-N-acetyl-D-mannosamine + ATP => aldehydo-N-acetyl-D-mannosamine 6-phosphate + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/25254""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-015_9191becad53a	RHEA:25254	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25254		"[{""reference_id"": ""RHEA:25254"", ""source_assertion"": ""Rhea release 142 places CHEBI:456216 with coefficient 1 on the products side of RHEA:25254. Its directional object is left_to_right relative to master RHEA:25253."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/25254\""]/rh:products; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25254"", ""title"": ""aldehydo-N-acetyl-D-mannosamine + ATP => aldehydo-N-acetyl-D-mannosamine 6-phosphate + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/25254""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-016_01a175d1eb07	RHEA:25254	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25254		"[{""reference_id"": ""RHEA:25254"", ""source_assertion"": ""Rhea release 142 places CHEBI:15378 with coefficient 1 on the products side of RHEA:25254. Its directional object is left_to_right relative to master RHEA:25253."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/25254\""]/rh:products; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25254"", ""title"": ""aldehydo-N-acetyl-D-mannosamine + ATP => aldehydo-N-acetyl-D-mannosamine 6-phosphate + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/25254""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-017_4057f5e2cdb5	RHEA:25254	BFO:0000050	MetaCyc:PWY0-1324	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1324		"[{""reference_id"": ""MetaCyc:PWY0-1324"", ""source_assertion"": ""The native child includes NANK-RXN; reaction layout and corresponding Rhea sides establish this degradation direction. RXN0-7389 uses native right-to-left ring opening; NANE-RXN maps to Rhea right-to-left."", ""source_locator"": ""Pathway/reaction-list, reaction-layout and reaction-ordering""}]"	"[{""id"": ""MetaCyc:PWY0-1324"", ""title"": ""N-acetylneuraminate and N-acetylmannosamine degradation I"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=PWY0-1324""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-018_258383d4041a	CHEBI:58557	pathwaymech:consumes	RHEA:25259	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25259		"[{""reference_id"": ""RHEA:25259"", ""source_assertion"": ""Rhea release 142 places CHEBI:58557 with coefficient 1 on the substrates side of RHEA:25259. Its directional object is right_to_left relative to master RHEA:25257."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/25259\""]/rh:substrates; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25259"", ""title"": ""aldehydo-N-acetyl-D-mannosamine 6-phosphate => N-acetyl-D-glucosamine 6-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/25259""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-019_6dd60e09f314	RHEA:25259	pathwaymech:produces	CHEBI:57513	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25259		"[{""reference_id"": ""RHEA:25259"", ""source_assertion"": ""Rhea release 142 places CHEBI:57513 with coefficient 1 on the products side of RHEA:25259. Its directional object is right_to_left relative to master RHEA:25257."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/25259\""]/rh:products; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25259"", ""title"": ""aldehydo-N-acetyl-D-mannosamine 6-phosphate => N-acetyl-D-glucosamine 6-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/25259""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-020_edee96c8218b	RHEA:25259	BFO:0000050	MetaCyc:PWY0-1324	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1324		"[{""reference_id"": ""MetaCyc:PWY0-1324"", ""source_assertion"": ""The native child includes NANE-RXN; reaction layout and corresponding Rhea sides establish this degradation direction. RXN0-7389 uses native right-to-left ring opening; NANE-RXN maps to Rhea right-to-left."", ""source_locator"": ""Pathway/reaction-list, reaction-layout and reaction-ordering""}]"	"[{""id"": ""MetaCyc:PWY0-1324"", ""title"": ""N-acetylneuraminate and N-acetylmannosamine degradation I"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=PWY0-1324""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-021_5b9b1c3a8b88	CHEBI:57513	pathwaymech:consumes	RHEA:22937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22937		"[{""reference_id"": ""RHEA:22937"", ""source_assertion"": ""Rhea release 142 places CHEBI:57513 with coefficient 1 on the substrates side of RHEA:22937. Its directional object is left_to_right relative to master RHEA:22936."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/22937\""]/rh:substrates; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22937"", ""title"": ""N-acetyl-D-glucosamine 6-phosphate + H2O => D-glucosamine 6-phosphate + acetate"", ""url"": ""https://www.rhea-db.org/rhea/22937""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-022_a7e3a2cca527	CHEBI:15377	pathwaymech:consumes	RHEA:22937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22937		"[{""reference_id"": ""RHEA:22937"", ""source_assertion"": ""Rhea release 142 places CHEBI:15377 with coefficient 1 on the substrates side of RHEA:22937. Its directional object is left_to_right relative to master RHEA:22936."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/22937\""]/rh:substrates; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22937"", ""title"": ""N-acetyl-D-glucosamine 6-phosphate + H2O => D-glucosamine 6-phosphate + acetate"", ""url"": ""https://www.rhea-db.org/rhea/22937""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-023_68aee8774cc2	RHEA:22937	pathwaymech:produces	CHEBI:58725	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22937		"[{""reference_id"": ""RHEA:22937"", ""source_assertion"": ""Rhea release 142 places CHEBI:58725 with coefficient 1 on the products side of RHEA:22937. Its directional object is left_to_right relative to master RHEA:22936."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/22937\""]/rh:products; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22937"", ""title"": ""N-acetyl-D-glucosamine 6-phosphate + H2O => D-glucosamine 6-phosphate + acetate"", ""url"": ""https://www.rhea-db.org/rhea/22937""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-024_6849ffeca094	RHEA:22937	pathwaymech:produces	CHEBI:30089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22937		"[{""reference_id"": ""RHEA:22937"", ""source_assertion"": ""Rhea release 142 places CHEBI:30089 with coefficient 1 on the products side of RHEA:22937. Its directional object is left_to_right relative to master RHEA:22936."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/22937\""]/rh:products; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22937"", ""title"": ""N-acetyl-D-glucosamine 6-phosphate + H2O => D-glucosamine 6-phosphate + acetate"", ""url"": ""https://www.rhea-db.org/rhea/22937""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-025_f2796277a11b	RHEA:22937	BFO:0000050	MetaCyc:GLUAMCAT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLUAMCAT-PWY		"[{""reference_id"": ""MetaCyc:GLUAMCAT-PWY"", ""source_assertion"": ""The child pathway contains sequential NAG6PDEACET-RXN and GLUCOSAMINE-6-P-DEAMIN-RXN in their degradation directions."", ""source_locator"": ""Pathway/reaction-list and reaction-layout""}]"	"[{""id"": ""MetaCyc:GLUAMCAT-PWY"", ""title"": ""N-acetylglucosamine degradation I"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=GLUAMCAT-PWY""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-026_7c1d55cb62a9	CHEBI:75989	pathwaymech:consumes	RHEA:12173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12173		"[{""reference_id"": ""RHEA:12173"", ""source_assertion"": ""Rhea release 142 places CHEBI:75989 with coefficient 1 on the substrates side of RHEA:12173. Its directional object is left_to_right relative to master RHEA:12172."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/12173\""]/rh:substrates; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12173"", ""title"": ""alpha-D-glucosamine 6-phosphate + H2O => beta-D-fructose 6-phosphate + NH4(+)"", ""url"": ""https://www.rhea-db.org/rhea/12173""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-027_0ef031db355f	CHEBI:15377	pathwaymech:consumes	RHEA:12173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12173		"[{""reference_id"": ""RHEA:12173"", ""source_assertion"": ""Rhea release 142 places CHEBI:15377 with coefficient 1 on the substrates side of RHEA:12173. Its directional object is left_to_right relative to master RHEA:12172."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/12173\""]/rh:substrates; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12173"", ""title"": ""alpha-D-glucosamine 6-phosphate + H2O => beta-D-fructose 6-phosphate + NH4(+)"", ""url"": ""https://www.rhea-db.org/rhea/12173""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-028_31fcb725f0d8	RHEA:12173	pathwaymech:produces	CHEBI:57634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12173		"[{""reference_id"": ""RHEA:12173"", ""source_assertion"": ""Rhea release 142 places CHEBI:57634 with coefficient 1 on the products side of RHEA:12173. Its directional object is left_to_right relative to master RHEA:12172."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/12173\""]/rh:products; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12173"", ""title"": ""alpha-D-glucosamine 6-phosphate + H2O => beta-D-fructose 6-phosphate + NH4(+)"", ""url"": ""https://www.rhea-db.org/rhea/12173""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-029_2a668250d6d0	RHEA:12173	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12173		"[{""reference_id"": ""RHEA:12173"", ""source_assertion"": ""Rhea release 142 places CHEBI:28938 with coefficient 1 on the products side of RHEA:12173. Its directional object is left_to_right relative to master RHEA:12172."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/12173\""]/rh:products; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12173"", ""title"": ""alpha-D-glucosamine 6-phosphate + H2O => beta-D-fructose 6-phosphate + NH4(+)"", ""url"": ""https://www.rhea-db.org/rhea/12173""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-030_8d80d1fd0508	RHEA:12173	BFO:0000050	MetaCyc:GLUAMCAT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLUAMCAT-PWY		"[{""reference_id"": ""MetaCyc:GLUAMCAT-PWY"", ""source_assertion"": ""The child pathway contains sequential NAG6PDEACET-RXN and GLUCOSAMINE-6-P-DEAMIN-RXN in their degradation directions."", ""source_locator"": ""Pathway/reaction-list and reaction-layout""}]"	"[{""id"": ""MetaCyc:GLUAMCAT-PWY"", ""title"": ""N-acetylglucosamine degradation I"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=GLUAMCAT-PWY""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-031_5609bc7d8d30	CHEBI:35418	pathwaymech:consumes	RHEA:28989	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28989		"[{""reference_id"": ""RHEA:28989"", ""source_assertion"": ""Rhea release 142 places CHEBI:35418 with coefficient 1 on the substrates side of RHEA:28989. Its directional object is right_to_left relative to master RHEA:28987."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28989\""]/rh:substrates; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28989"", ""title"": ""N-acetylneuraminate(out) + H(+)(out) => N-acetylneuraminate(in) + H(+)(in)"", ""url"": ""https://www.rhea-db.org/rhea/28989""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-032_85bef481208e	CHEBI:15378	pathwaymech:consumes	RHEA:28989	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28989		"[{""reference_id"": ""RHEA:28989"", ""source_assertion"": ""Rhea release 142 places CHEBI:15378 with coefficient 1 on the substrates side of RHEA:28989. Its directional object is right_to_left relative to master RHEA:28987."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28989\""]/rh:substrates; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28989"", ""title"": ""N-acetylneuraminate(out) + H(+)(out) => N-acetylneuraminate(in) + H(+)(in)"", ""url"": ""https://www.rhea-db.org/rhea/28989""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-033_20689b01f8f3	RHEA:28989	pathwaymech:produces	CHEBI:35418	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28989		"[{""reference_id"": ""RHEA:28989"", ""source_assertion"": ""Rhea release 142 places CHEBI:35418 with coefficient 1 on the products side of RHEA:28989. Its directional object is right_to_left relative to master RHEA:28987."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28989\""]/rh:products; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28989"", ""title"": ""N-acetylneuraminate(out) + H(+)(out) => N-acetylneuraminate(in) + H(+)(in)"", ""url"": ""https://www.rhea-db.org/rhea/28989""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-034_3da26f14ef4c	RHEA:28989	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28989		"[{""reference_id"": ""RHEA:28989"", ""source_assertion"": ""Rhea release 142 places CHEBI:15378 with coefficient 1 on the products side of RHEA:28989. Its directional object is right_to_left relative to master RHEA:28987."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28989\""]/rh:products; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28989"", ""title"": ""N-acetylneuraminate(out) + H(+)(out) => N-acetylneuraminate(in) + H(+)(in)"", ""url"": ""https://www.rhea-db.org/rhea/28989""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-035_883da8e03c60	RHEA-COMP:9746	pathwaymech:consumes	RHEA:49241	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:49241		"[{""reference_id"": ""RHEA:49241"", ""source_assertion"": ""Rhea release 142 places RHEA-COMP:9746 with coefficient 1 on the substrates side of RHEA:49241. Its directional object is left_to_right relative to master RHEA:49240."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/49241\""]/rh:substrates; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:49241"", ""title"": ""N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) => N-acetyl-D-glucosamine 6-phosphate(in) + L-histidyl-[protein]"", ""url"": ""https://www.rhea-db.org/rhea/49241""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-036_938acd3f8a4e	CHEBI:506227	pathwaymech:consumes	RHEA:49241	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:49241		"[{""reference_id"": ""RHEA:49241"", ""source_assertion"": ""Rhea release 142 places CHEBI:506227 with coefficient 1 on the substrates side of RHEA:49241. Its directional object is left_to_right relative to master RHEA:49240."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/49241\""]/rh:substrates; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:49241"", ""title"": ""N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) => N-acetyl-D-glucosamine 6-phosphate(in) + L-histidyl-[protein]"", ""url"": ""https://www.rhea-db.org/rhea/49241""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-037_ac68d6d2f58d	RHEA:49241	pathwaymech:produces	CHEBI:57513	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:49241		"[{""reference_id"": ""RHEA:49241"", ""source_assertion"": ""Rhea release 142 places CHEBI:57513 with coefficient 1 on the products side of RHEA:49241. Its directional object is left_to_right relative to master RHEA:49240."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/49241\""]/rh:products; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:49241"", ""title"": ""N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) => N-acetyl-D-glucosamine 6-phosphate(in) + L-histidyl-[protein]"", ""url"": ""https://www.rhea-db.org/rhea/49241""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-038_d239cd662667	RHEA:49241	pathwaymech:produces	RHEA-COMP:9745	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:49241		"[{""reference_id"": ""RHEA:49241"", ""source_assertion"": ""Rhea release 142 places RHEA-COMP:9745 with coefficient 1 on the products side of RHEA:49241. Its directional object is left_to_right relative to master RHEA:49240."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/49241\""]/rh:products; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:49241"", ""title"": ""N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) => N-acetyl-D-glucosamine 6-phosphate(in) + L-histidyl-[protein]"", ""url"": ""https://www.rhea-db.org/rhea/49241""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-039_801ae627626c	RHEA-COMP:9745	pathwaymech:consumes	RHEA:23881	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23881		"[{""reference_id"": ""RHEA:23881"", ""source_assertion"": ""Rhea release 142 places RHEA-COMP:9745 with coefficient 1 on the substrates side of RHEA:23881. Its directional object is left_to_right relative to master RHEA:23880."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/23881\""]/rh:substrates; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23881"", ""title"": ""L-histidyl-[protein] + phosphoenolpyruvate => N(pros)-phospho-L-histidyl-[protein] + pyruvate"", ""url"": ""https://www.rhea-db.org/rhea/23881""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-040_402ad2c2f28f	CHEBI:58702	pathwaymech:consumes	RHEA:23881	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23881		"[{""reference_id"": ""RHEA:23881"", ""source_assertion"": ""Rhea release 142 places CHEBI:58702 with coefficient 1 on the substrates side of RHEA:23881. Its directional object is left_to_right relative to master RHEA:23880."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/23881\""]/rh:substrates; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23881"", ""title"": ""L-histidyl-[protein] + phosphoenolpyruvate => N(pros)-phospho-L-histidyl-[protein] + pyruvate"", ""url"": ""https://www.rhea-db.org/rhea/23881""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-041_0bf1b1e1ac30	RHEA:23881	pathwaymech:produces	RHEA-COMP:9746	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23881		"[{""reference_id"": ""RHEA:23881"", ""source_assertion"": ""Rhea release 142 places RHEA-COMP:9746 with coefficient 1 on the products side of RHEA:23881. Its directional object is left_to_right relative to master RHEA:23880."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/23881\""]/rh:products; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23881"", ""title"": ""L-histidyl-[protein] + phosphoenolpyruvate => N(pros)-phospho-L-histidyl-[protein] + pyruvate"", ""url"": ""https://www.rhea-db.org/rhea/23881""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-042_1ff61395457f	RHEA:23881	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23881		"[{""reference_id"": ""RHEA:23881"", ""source_assertion"": ""Rhea release 142 places CHEBI:15361 with coefficient 1 on the products side of RHEA:23881. Its directional object is left_to_right relative to master RHEA:23880."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/23881\""]/rh:products; rh:contains and coefficient predicate rh:contains1; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23881"", ""title"": ""L-histidyl-[protein] + phosphoenolpyruvate => N(pros)-phospho-L-histidyl-[protein] + pyruvate"", ""url"": ""https://www.rhea-db.org/rhea/23881""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-043_f83ecf30f5ca	BiGG:acmana	pathwaymech:consumes	BiGG:ACMANAptspp	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	BiGG:ACMANAptspp|BiGG:acmana|CHEBI:17122		"[{""reference_id"": ""BiGG:ACMANAptspp"", ""source_assertion"": ""iML1515 assigns acmana_p (p compartment) coefficient -1; lower_bound=0 and upper_bound=1000 permit the written uptake direction. This is the coupled PEP-dependent transport reaction, not an elementary phosphoryl transfer."", ""source_locator"": ""iML1515/reactions[id=ACMANAptspp]/metabolites/acmana_p; bounds; metabolites[id=acmana_p]""}, {""reference_id"": ""BiGG:acmana"", ""source_assertion"": ""The native substrate annotation gives InChIKey MBLBDJOUHNCFQT-XAMCCFCMSA-N and multiple ChEBI cross-references. This model compound is retained without an exact ChEBI alias; the cross-references do not resolve their conflicting structural scope."", ""source_locator"": ""Universal metabolite database_links[InChI Key, CHEBI]; iML1515/metabolites[id=acmana_p]/annotation""}, {""reference_id"": ""CHEBI:17122"", ""source_assertion"": ""The issuing ChEBI SQL record gives MBLBDJOUHNCFQT-WCTZXXKLSA-N. Its different stereochemical hash block prevents equating this exact aldehydo species to the BiGG substrate annotation. No conversion between these structures is inferred."", ""source_locator"": ""ChEBI release 255 statements[subject=CHEBI:17122,predicate=chemrof:inchi_key_string]""}]"	"[{""id"": ""BiGG:ACMANAptspp"", ""title"": ""N-acetyl-D-mannosamine transport via PTS  (periplasm)"", ""url"": ""https://bigg.ucsd.edu/universal/reactions/ACMANAptspp""}, {""id"": ""BiGG:acmana"", ""title"": ""N-Acetyl-D-mannosamine"", ""url"": ""https://bigg.ucsd.edu/models/universal/metabolites/acmana""}, {""id"": ""CHEBI:17122"", ""title"": ""aldehydo-N-acetyl-D-mannosamine"", ""url"": ""https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:17122""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-044_cd0037e46a8c	BiGG:ACMANAptspp	pathwaymech:produces	BiGG:acmanap	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	BiGG:ACMANAptspp		"[{""reference_id"": ""BiGG:ACMANAptspp"", ""source_assertion"": ""iML1515 assigns acmanap_c (c compartment) coefficient 1; lower_bound=0 and upper_bound=1000 permit the written uptake direction. This is the coupled PEP-dependent transport reaction, not an elementary phosphoryl transfer."", ""source_locator"": ""iML1515/reactions[id=ACMANAptspp]/metabolites/acmanap_c; bounds; metabolites[id=acmanap_c]""}]"	"[{""id"": ""BiGG:ACMANAptspp"", ""title"": ""N-acetyl-D-mannosamine transport via PTS  (periplasm)"", ""url"": ""https://bigg.ucsd.edu/universal/reactions/ACMANAptspp""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-045_677ac6144634	CHEBI:58702	pathwaymech:consumes	BiGG:ACMANAptspp	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	BiGG:ACMANAptspp		"[{""reference_id"": ""BiGG:ACMANAptspp"", ""source_assertion"": ""iML1515 assigns pep_c (c compartment) coefficient -1; lower_bound=0 and upper_bound=1000 permit the written uptake direction. This is the coupled PEP-dependent transport reaction, not an elementary phosphoryl transfer."", ""source_locator"": ""iML1515/reactions[id=ACMANAptspp]/metabolites/pep_c; bounds; metabolites[id=pep_c]""}]"	"[{""id"": ""BiGG:ACMANAptspp"", ""title"": ""N-acetyl-D-mannosamine transport via PTS  (periplasm)"", ""url"": ""https://bigg.ucsd.edu/universal/reactions/ACMANAptspp""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-046_aaa1a022b08c	BiGG:ACMANAptspp	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	BiGG:ACMANAptspp		"[{""reference_id"": ""BiGG:ACMANAptspp"", ""source_assertion"": ""iML1515 assigns pyr_c (c compartment) coefficient 1; lower_bound=0 and upper_bound=1000 permit the written uptake direction. This is the coupled PEP-dependent transport reaction, not an elementary phosphoryl transfer."", ""source_locator"": ""iML1515/reactions[id=ACMANAptspp]/metabolites/pyr_c; bounds; metabolites[id=pyr_c]""}]"	"[{""id"": ""BiGG:ACMANAptspp"", ""title"": ""N-acetyl-D-mannosamine transport via PTS  (periplasm)"", ""url"": ""https://bigg.ucsd.edu/universal/reactions/ACMANAptspp""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-047_e8c1a1067f3c	BiGG:ACMANAptspp	BFO:0000050	MetaCyc:GLCMANNANAUT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9864311		"[{""reference_id"": ""PMID:9864311"", ""source_assertion"": ""Extracellular ManNAc enters through ManXYZ-dependent PTS uptake and phosphorylation. Rapid growth in the tested K-12 backgrounds required mlc/nanR derepression; this is an entry route to the complete superpathway."", ""source_locator"": ""PMC103530, Results, Transport and phosphorylation of ManNAc; Table 1 and Fig. 1""}]"	"[{""id"": ""PMID:9864311"", ""title"": ""Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9864311""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-048_5dffb174acf9	RHEA:28989	BFO:0000050	MetaCyc:GLCMANNANAUT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLCMANNANAUT-PWY		"[{""reference_id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""source_assertion"": ""The superpathway definition explicitly includes transport and convergence of neuraminate, mannosamine and glucosamine acetylated amino sugars at N-acetylglucosamine 6-phosphate. Individual transport chemistry is separately grounded."", ""source_locator"": ""Pathway/comment; Plumbridge99""}]"	"[{""id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""title"": ""MetaCyc:GLCMANNANAUT-PWY"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=GLCMANNANAUT-PWY""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-049_2509534b4902	RHEA:49241	BFO:0000050	MetaCyc:GLCMANNANAUT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLCMANNANAUT-PWY		"[{""reference_id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""source_assertion"": ""The superpathway definition explicitly includes transport and convergence of neuraminate, mannosamine and glucosamine acetylated amino sugars at N-acetylglucosamine 6-phosphate. Individual transport chemistry is separately grounded."", ""source_locator"": ""Pathway/comment; Plumbridge99""}]"	"[{""id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""title"": ""MetaCyc:GLCMANNANAUT-PWY"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=GLCMANNANAUT-PWY""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-050_36dd734e3f6f	MetaCyc:ACNEULY-CPLX	BFO:0000051	UniProtKB:P0A6L4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ACNEULY-CPLX|UniProtKB:P0A6L4		"[{""reference_id"": ""MetaCyc:ACNEULY-CPLX"", ""source_assertion"": ""META 27.0 assigns component ACNEULY-MONOMER coefficient 4."", ""source_locator"": ""Protein[@frameid=\""ACNEULY-CPLX\""]/component[Protein/@frameid=\""ACNEULY-MONOMER\""]/coefficient""}, {""reference_id"": ""UniProtKB:P0A6L4"", ""source_assertion"": ""The reviewed protein entry cross-references native ACNEULY-MONOMER; this identifies the corresponding polypeptide without altering the native assembly coefficient."", ""source_locator"": ""uniProtKBCrossReferences[database=BioCyc]""}]"	"[{""id"": ""MetaCyc:ACNEULY-CPLX"", ""title"": ""N-acetylneuraminate lyase"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=ACNEULY-CPLX""}, {""id"": ""UniProtKB:P0A6L4"", ""title"": ""N-acetylneuraminate lyase"", ""url"": ""https://www.uniprot.org/uniprotkb/P0A6L4""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-051_5da4ef9c6256	MetaCyc:CPLX0-8588	BFO:0000051	UniProtKB:P45425	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8588|UniProtKB:P45425		"[{""reference_id"": ""MetaCyc:CPLX0-8588"", ""source_assertion"": ""META 27.0 assigns component NANK-MONOMER coefficient 2."", ""source_locator"": ""Protein[@frameid=\""CPLX0-8588\""]/component[Protein/@frameid=\""NANK-MONOMER\""]/coefficient""}, {""reference_id"": ""UniProtKB:P45425"", ""source_assertion"": ""The reviewed protein entry cross-references native NANK-MONOMER; this identifies the corresponding polypeptide without altering the native assembly coefficient."", ""source_locator"": ""uniProtKBCrossReferences[database=BioCyc]""}]"	"[{""id"": ""MetaCyc:CPLX0-8588"", ""title"": ""N-acetylmannosamine kinase"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=CPLX0-8588""}, {""id"": ""UniProtKB:P45425"", ""title"": ""N-acetylmannosamine kinase"", ""url"": ""https://www.uniprot.org/uniprotkb/P45425""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-052_8beb2586ae60	MetaCyc:NAG6PDEACET-CPLX	BFO:0000051	UniProtKB:P0AF18	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:NAG6PDEACET-CPLX|PMID:17567047|UniProtKB:P0AF18		"[{""reference_id"": ""MetaCyc:NAG6PDEACET-CPLX"", ""source_assertion"": ""META 27.0 assigns component NAG6PDEACET-MONOMER coefficient 4."", ""source_locator"": ""Protein[@frameid=\""NAG6PDEACET-CPLX\""]/component[Protein/@frameid=\""NAG6PDEACET-MONOMER\""]/coefficient""}, {""reference_id"": ""UniProtKB:P0AF18"", ""source_assertion"": ""The reviewed protein entry cross-references native NAG6PDEACET-MONOMER; this identifies the corresponding polypeptide without altering the native assembly coefficient."", ""source_locator"": ""uniProtKBCrossReferences[database=BioCyc]""}, {""reference_id"": ""PMID:17567047"", ""source_assertion"": ""Purified E. coli NagA behaved as a tetramer in the presence of disulfide reducing agents; the primary experiment does not claim that disulfides are required for the native assembly."", ""source_locator"": ""PMC2533526, Results and Discussion S15""}]"	"[{""id"": ""MetaCyc:NAG6PDEACET-CPLX"", ""title"": ""N-acetylglucosamine-6-phosphate deacetylase"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=NAG6PDEACET-CPLX""}, {""id"": ""PMID:17567047"", ""title"": ""N-Acetyl-D-glucosamine-6-phosphate deacetylase: substrate activation via a single divalent metal ion."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/17567047""}, {""id"": ""UniProtKB:P0AF18"", ""title"": ""N-acetylglucosamine-6-phosphate deacetylase"", ""url"": ""https://www.uniprot.org/uniprotkb/P0AF18""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-053_56aeaad29786	MetaCyc:GLUCOSAMINE-6-P-DEAMIN-CPLX	BFO:0000051	UniProtKB:P0A759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLUCOSAMINE-6-P-DEAMIN-CPLX|PMID:8240271|UniProtKB:P0A759		"[{""reference_id"": ""MetaCyc:GLUCOSAMINE-6-P-DEAMIN-CPLX"", ""source_assertion"": ""META 27.0 assigns component GLUCOSAMINE-6-P-DEAMIN-MONOMER coefficient 6."", ""source_locator"": ""Protein[@frameid=\""GLUCOSAMINE-6-P-DEAMIN-CPLX\""]/component[Protein/@frameid=\""GLUCOSAMINE-6-P-DEAMIN-MONOMER\""]/coefficient""}, {""reference_id"": ""UniProtKB:P0A759"", ""source_assertion"": ""The reviewed protein entry cross-references native GLUCOSAMINE-6-P-DEAMIN-MONOMER; this identifies the corresponding polypeptide without altering the native assembly coefficient."", ""source_locator"": ""uniProtKBCrossReferences[database=BioCyc]""}, {""reference_id"": ""PMID:8240271"", ""source_assertion"": ""The abstract describes a hexamer arranged as a trimer of dimers; Cys-to-Ser variants lacking the interchain disulfide remain stable hexamers. Full scanned article access failed, so no further full-text claim is made."", ""source_locator"": ""Primary abstract; PMC1134607 abstract1""}]"	"[{""id"": ""MetaCyc:GLUCOSAMINE-6-P-DEAMIN-CPLX"", ""title"": ""glucosamine-6-phosphate deaminase"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=GLUCOSAMINE-6-P-DEAMIN-CPLX""}, {""id"": ""PMID:8240271"", ""title"": ""Glucosamine-6-phosphate deaminase from Escherichia coli has a trimer of dimers structure with three intersubunit disulphides."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/8240271""}, {""id"": ""UniProtKB:P0A759"", ""title"": ""Glucosamine-6-phosphate deaminase"", ""url"": ""https://www.uniprot.org/uniprotkb/P0A759""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-054_8f55d5685e1a	MetaCyc:CPLX0-7938	BFO:0000051	UniProtKB:P08839	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7938|UniProtKB:P08839		"[{""reference_id"": ""MetaCyc:CPLX0-7938"", ""source_assertion"": ""META 27.0 assigns component PTSI-MONOMER coefficient 2."", ""source_locator"": ""Protein[@frameid=\""CPLX0-7938\""]/component[Protein/@frameid=\""PTSI-MONOMER\""]/coefficient""}, {""reference_id"": ""UniProtKB:P08839"", ""source_assertion"": ""The reviewed protein entry cross-references native PTSI-MONOMER; this identifies the corresponding polypeptide without altering the native assembly coefficient."", ""source_locator"": ""uniProtKBCrossReferences[database=BioCyc]""}]"	"[{""id"": ""MetaCyc:CPLX0-7938"", ""title"": ""PTS enzyme I"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=CPLX0-7938""}, {""id"": ""UniProtKB:P08839"", ""title"": ""Phosphoenolpyruvate-protein phosphotransferase"", ""url"": ""https://www.uniprot.org/uniprotkb/P08839""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-055_07b9836dc5e6	MetaCyc:CPLX0-7921	BFO:0000051	UniProtKB:P69797	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7921|UniProtKB:P69797		"[{""reference_id"": ""MetaCyc:CPLX0-7921"", ""source_assertion"": ""META 27.0 assigns component MANX-MONOMER coefficient 2."", ""source_locator"": ""Protein[@frameid=\""CPLX0-7921\""]/component[Protein/@frameid=\""MANX-MONOMER\""]/coefficient""}, {""reference_id"": ""UniProtKB:P69797"", ""source_assertion"": ""The reviewed protein entry cross-references native MANX-MONOMER; this identifies the corresponding polypeptide without altering the native assembly coefficient."", ""source_locator"": ""uniProtKBCrossReferences[database=BioCyc]""}]"	"[{""id"": ""MetaCyc:CPLX0-7921"", ""title"": ""mannose-specific PTS enzyme IIAB component"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=CPLX0-7921""}, {""id"": ""UniProtKB:P69797"", ""title"": ""PTS system mannose-specific EIIAB component"", ""url"": ""https://www.uniprot.org/uniprotkb/P69797""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-056_aa17f85ba1f2	MetaCyc:CPLX-165	BFO:0000051	UniProtKB:P69805	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-165|PMID:31209249|UniProtKB:P69805		"[{""reference_id"": ""MetaCyc:CPLX-165"", ""source_assertion"": ""META 27.0 assigns component MANZ-MONOMER coefficient 3."", ""source_locator"": ""Protein[@frameid=\""CPLX-165\""]/component[Protein/@frameid=\""MANZ-MONOMER\""]/coefficient""}, {""reference_id"": ""UniProtKB:P69805"", ""source_assertion"": ""The reviewed protein entry cross-references native MANZ-MONOMER; this identifies the corresponding polypeptide without altering the native assembly coefficient."", ""source_locator"": ""uniProtKBCrossReferences[database=BioCyc]""}, {""reference_id"": ""PMID:31209249"", ""source_assertion"": ""Cryo-EM resolves a ManYZ trimer with one ManY and one ManZ per protomer. The isolated structural assembly does not include ManX and does not fix complete ManXYZ stoichiometry."", ""source_locator"": ""PMC6796895, main letter paragraphs beginning In this study and The structure of ManYZ; Fig. 1a/b""}]"	"[{""id"": ""MetaCyc:CPLX-165"", ""title"": ""mannose-specific PTS enzyme II"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=CPLX-165""}, {""id"": ""PMID:31209249"", ""title"": ""Structure of the mannose transporter of the bacterial phosphotransferase system."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/31209249""}, {""id"": ""UniProtKB:P69805"", ""title"": ""PTS system mannose-specific EIID component"", ""url"": ""https://www.uniprot.org/uniprotkb/P69805""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-057_eff62addc9e2	MetaCyc:CPLX-165	BFO:0000051	UniProtKB:P69801	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-165|PMID:31209249|UniProtKB:P69801		"[{""reference_id"": ""MetaCyc:CPLX-165"", ""source_assertion"": ""META 27.0 assigns component MANY-MONOMER coefficient 3."", ""source_locator"": ""Protein[@frameid=\""CPLX-165\""]/component[Protein/@frameid=\""MANY-MONOMER\""]/coefficient""}, {""reference_id"": ""UniProtKB:P69801"", ""source_assertion"": ""The reviewed protein entry cross-references native MANY-MONOMER; this identifies the corresponding polypeptide without altering the native assembly coefficient."", ""source_locator"": ""uniProtKBCrossReferences[database=BioCyc]""}, {""reference_id"": ""PMID:31209249"", ""source_assertion"": ""Cryo-EM resolves a ManYZ trimer with one ManY and one ManZ per protomer. The isolated structural assembly does not include ManX and does not fix complete ManXYZ stoichiometry."", ""source_locator"": ""PMC6796895, main letter paragraphs beginning In this study and The structure of ManYZ; Fig. 1a/b""}]"	"[{""id"": ""MetaCyc:CPLX-165"", ""title"": ""mannose-specific PTS enzyme II"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=CPLX-165""}, {""id"": ""PMID:31209249"", ""title"": ""Structure of the mannose transporter of the bacterial phosphotransferase system."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/31209249""}, {""id"": ""UniProtKB:P69801"", ""title"": ""PTS system mannose-specific EIIC component"", ""url"": ""https://www.uniprot.org/uniprotkb/P69801""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-058_7b672e95de30	MetaCyc:CPLX-165	BFO:0000051	UniProtKB:P69797	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-165|UniProtKB:P69797		"[{""reference_id"": ""MetaCyc:CPLX-165"", ""source_assertion"": ""META 27.0 assigns component MANX-MONOMER coefficient 1. ManYZ cryo-EM resolves three Y/Z pairs without ManX; native ManX also has a separately annotated dimer. Do not infer a reconciled full-complex stoichiometry."", ""source_locator"": ""Protein[@frameid=\""CPLX-165\""]/component[Protein/@frameid=\""MANX-MONOMER\""]/coefficient""}, {""reference_id"": ""UniProtKB:P69797"", ""source_assertion"": ""The reviewed protein entry cross-references native MANX-MONOMER; this identifies the corresponding polypeptide without altering the native assembly coefficient."", ""source_locator"": ""uniProtKBCrossReferences[database=BioCyc]""}]"	"[{""id"": ""MetaCyc:CPLX-165"", ""title"": ""mannose-specific PTS enzyme II"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=CPLX-165""}, {""id"": ""UniProtKB:P69797"", ""title"": ""PTS system mannose-specific EIIAB component"", ""url"": ""https://www.uniprot.org/uniprotkb/P69797""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-059_bcb3c652c252	MetaCyc:CPLX-167	BFO:0000051	UniProtKB:P09323	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-167|UniProtKB:P09323		"[{""reference_id"": ""MetaCyc:CPLX-167"", ""source_assertion"": ""META 27.0 assigns component NAGE-MONOMER coefficient 2."", ""source_locator"": ""Protein[@frameid=\""CPLX-167\""]/component[Protein/@frameid=\""NAGE-MONOMER\""]/coefficient""}, {""reference_id"": ""UniProtKB:P09323"", ""source_assertion"": ""The reviewed protein entry cross-references native NAGE-MONOMER; this identifies the corresponding polypeptide without altering the native assembly coefficient."", ""source_locator"": ""uniProtKBCrossReferences[database=BioCyc]""}]"	"[{""id"": ""MetaCyc:CPLX-167"", ""title"": ""N-acetylglucosamine-specific PTS enzyme II"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=CPLX-167""}, {""id"": ""UniProtKB:P09323"", ""title"": ""PTS system N-acetylglucosamine-specific EIICBA component"", ""url"": ""https://www.uniprot.org/uniprotkb/P09323""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-060_55e0018c8fc7	MetaCyc:PIIPROTEIN-CPLX	BFO:0000051	UniProtKB:P0A9Z1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PIIPROTEIN-CPLX|UniProtKB:P0A9Z1		"[{""reference_id"": ""MetaCyc:PIIPROTEIN-CPLX"", ""source_assertion"": ""META 27.0 assigns component PROTEIN-PII coefficient 3."", ""source_locator"": ""Protein[@frameid=\""PIIPROTEIN-CPLX\""]/component[Protein/@frameid=\""PROTEIN-PII\""]/coefficient""}, {""reference_id"": ""UniProtKB:P0A9Z1"", ""source_assertion"": ""The reviewed protein entry cross-references native PROTEIN-PII; this identifies the corresponding polypeptide without altering the native assembly coefficient."", ""source_locator"": ""uniProtKBCrossReferences[database=BioCyc]""}]"	"[{""id"": ""MetaCyc:PIIPROTEIN-CPLX"", ""title"": ""nitrogen regulatory protein PII-1"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=PIIPROTEIN-CPLX""}, {""id"": ""UniProtKB:P0A9Z1"", ""title"": ""Nitrogen regulatory protein P-II 1"", ""url"": ""https://www.uniprot.org/uniprotkb/P0A9Z1""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-061_2b855cd702b4	MetaCyc:PIIPROTEIN-CPLX	BFO:0000050	MetaCyc:GLCMANNANAUT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9Z1		"[{""reference_id"": ""UniProtKB:P0A9Z1"", ""source_assertion"": ""GlnB is a homotrimer. Its uridylylation state controls the separately qualified NagB assays; this native assembly node does not imply an occupancy or assembly for those preparations."", ""source_locator"": ""comments[commentType=SUBUNIT]; PMID:29229699 methods sec4-6""}]"	"[{""id"": ""UniProtKB:P0A9Z1"", ""title"": ""Nitrogen regulatory protein P-II 1"", ""url"": ""https://www.uniprot.org/uniprotkb/P0A9Z1""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-062_b052138acc8f	MetaCyc:CPLX0-8568	BFO:0000050	MetaCyc:GLCMANNANAUT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8568		"[{""reference_id"": ""MetaCyc:CPLX0-8568"", ""source_assertion"": ""The native modified PII-1 complex has unmodified-form PIIPROTEIN-CPLX, but this original gives no component coefficients or uridylylation occupancy. It is retained as state context, not equated to an assay preparation."", ""source_locator"": ""Protein/unmodified-form; common-name; absence of direct component slots""}]"	"[{""id"": ""MetaCyc:CPLX0-8568"", ""title"": ""uridylyl-[protein PII-1]"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=CPLX0-8568""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-063_c8e12da312fc	MetaCyc:ACNEULY-CPLX	pathwaymech:catalyzes	RHEA:23297	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ACNEULY-CPLX		"[{""reference_id"": ""MetaCyc:ACNEULY-CPLX"", ""source_assertion"": ""The exact native complex catalyzes an Enzymatic-Reaction with an enzyme back-reference to this frame and reaction RXN0-7390. The represented Rhea direction is the independently resolved degradation direction."", ""source_locator"": ""Protein/catalyzes/Enzymatic-Reaction/{enzyme,reaction}""}]"	"[{""id"": ""MetaCyc:ACNEULY-CPLX"", ""title"": ""N-acetylneuraminate lyase"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=ACNEULY-CPLX""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-064_60ca3f035b7a	MetaCyc:CPLX0-8588	pathwaymech:catalyzes	RHEA:25254	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8588		"[{""reference_id"": ""MetaCyc:CPLX0-8588"", ""source_assertion"": ""The exact native complex catalyzes an Enzymatic-Reaction with an enzyme back-reference to this frame and reaction NANK-RXN. The represented Rhea direction is the independently resolved degradation direction."", ""source_locator"": ""Protein/catalyzes/Enzymatic-Reaction/{enzyme,reaction}""}]"	"[{""id"": ""MetaCyc:CPLX0-8588"", ""title"": ""N-acetylmannosamine kinase"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=CPLX0-8588""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-065_3a8e1fd60481	MetaCyc:NAG6PDEACET-CPLX	pathwaymech:catalyzes	RHEA:22937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:NAG6PDEACET-CPLX		"[{""reference_id"": ""MetaCyc:NAG6PDEACET-CPLX"", ""source_assertion"": ""The exact native complex catalyzes an Enzymatic-Reaction with an enzyme back-reference to this frame and reaction NAG6PDEACET-RXN. The represented Rhea direction is the independently resolved degradation direction."", ""source_locator"": ""Protein/catalyzes/Enzymatic-Reaction/{enzyme,reaction}""}]"	"[{""id"": ""MetaCyc:NAG6PDEACET-CPLX"", ""title"": ""N-acetylglucosamine-6-phosphate deacetylase"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=NAG6PDEACET-CPLX""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-066_8955ec28c4d6	MetaCyc:GLUCOSAMINE-6-P-DEAMIN-CPLX	pathwaymech:catalyzes	RHEA:12173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLUCOSAMINE-6-P-DEAMIN-CPLX		"[{""reference_id"": ""MetaCyc:GLUCOSAMINE-6-P-DEAMIN-CPLX"", ""source_assertion"": ""The exact native complex catalyzes an Enzymatic-Reaction with an enzyme back-reference to this frame and reaction GLUCOSAMINE-6-P-DEAMIN-RXN. The represented Rhea direction is the independently resolved degradation direction."", ""source_locator"": ""Protein/catalyzes/Enzymatic-Reaction/{enzyme,reaction}""}]"	"[{""id"": ""MetaCyc:GLUCOSAMINE-6-P-DEAMIN-CPLX"", ""title"": ""glucosamine-6-phosphate deaminase"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=GLUCOSAMINE-6-P-DEAMIN-CPLX""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-067_43cdbcea0b20	UniProtKB:P45424	pathwaymech:catalyzes	RHEA:67741	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33895133|UniProtKB:P45424		"[{""reference_id"": ""UniProtKB:P45424"", ""source_assertion"": ""NanQ opens both beta- and alpha-Neu5Ac to aceneuramate and favors the beta anomer. The alpha route is a supported alternative beyond the native beta ring-opening step."", ""source_locator"": ""comments[commentType=FUNCTION], ECO:0000269 PMID:33895133""}, {""reference_id"": ""PMID:33895133"", ""source_assertion"": ""NanQ accelerates anomer opening to the linear substrate preferred by NanA. Growth defects of the knockout are conditional on assay temperature/pH; they do not establish universal essentiality."", ""source_locator"": ""PMC8141875, Results and Discussion, anomerase assays and mutant growth experiments""}]"	"[{""id"": ""PMID:33895133"", ""title"": ""The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/33895133""}, {""id"": ""UniProtKB:P45424"", ""title"": ""N-acetylneuraminate anomerase NanQ"", ""url"": ""https://www.uniprot.org/uniprotkb/P45424""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-068_64ee88f02a2f	UniProtKB:P45424	pathwaymech:catalyzes	RHEA:67737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33895133|UniProtKB:P45424		"[{""reference_id"": ""UniProtKB:P45424"", ""source_assertion"": ""NanQ opens both beta- and alpha-Neu5Ac to aceneuramate and favors the beta anomer. The alpha route is a supported alternative beyond the native beta ring-opening step."", ""source_locator"": ""comments[commentType=FUNCTION], ECO:0000269 PMID:33895133""}, {""reference_id"": ""PMID:33895133"", ""source_assertion"": ""NanQ accelerates anomer opening to the linear substrate preferred by NanA. Growth defects of the knockout are conditional on assay temperature/pH; they do not establish universal essentiality."", ""source_locator"": ""PMC8141875, Results and Discussion, anomerase assays and mutant growth experiments""}]"	"[{""id"": ""PMID:33895133"", ""title"": ""The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/33895133""}, {""id"": ""UniProtKB:P45424"", ""title"": ""N-acetylneuraminate anomerase NanQ"", ""url"": ""https://www.uniprot.org/uniprotkb/P45424""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-069_0360dc8b663d	UniProtKB:P0A761	pathwaymech:catalyzes	RHEA:25259	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A761		"[{""reference_id"": ""UniProtKB:P0A761"", ""source_assertion"": ""K-12 NanE is annotated as probable ManNAc6P-to-GlcNAc6P epimerase, ECO:0000305 from PMID:9864311. The homodimer annotation comes from HAMAP MF_01235, ECO:0000255, not purified K-12 assembly measurements."", ""source_locator"": ""comments[commentType=FUNCTION or SUBUNIT]""}]"	"[{""id"": ""UniProtKB:P0A761"", ""title"": ""N-acetylmannosamine-6-phosphate 2-epimerase"", ""url"": ""https://www.uniprot.org/uniprotkb/P0A761""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-070_b5926568f838	UniProtKB:P41036	pathwaymech:catalyzes	RHEA:28989	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:22167185|UniProtKB:P41036		"[{""reference_id"": ""UniProtKB:P41036"", ""source_assertion"": ""NanT mediates proton-dependent reversible sialic-acid transport. The imported direction shown serves catabolism; the Rhea formal one-proton equation is not a measured coupling stoichiometry."", ""source_locator"": ""comments[commentType=FUNCTION], PMID:22167185""}, {""reference_id"": ""PMID:22167185"", ""source_assertion"": ""E. coli K-12 NanT was reconstituted as a proton-driven transporter capable of counterflow; this differs from the sodium-driven TRAP transporter comparators."", ""source_locator"": ""PMC3271013, Results, NanT proton-dependence and counterflow experiments""}]"	"[{""id"": ""PMID:22167185"", ""title"": ""The membrane proteins SiaQ and SiaM form an essential stoichiometric complex in the sialic acid tripartite ATP-independent periplasmic (TRAP) transporter SiaPQM (VC1777-1779) from Vibrio cholerae."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/22167185""}, {""id"": ""UniProtKB:P41036"", ""title"": ""Sialic acid transporter NanT"", ""url"": ""https://www.uniprot.org/uniprotkb/P41036""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-071_b1fd9c16b97e	MetaCyc:CPLX-167	pathwaymech:catalyzes	RHEA:49241	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-167|PMID:9864311		"[{""reference_id"": ""MetaCyc:CPLX-167"", ""source_assertion"": ""Native catalyzes links include N-acetyl-D-glucosamine PTS permease activity. Transport phosphorylates incoming GlcNAc through the PTS relay; the Rhea histidyl-protein participants are formal generic states."", ""source_locator"": ""Protein/catalyzes/Enzymatic-Reaction""}, {""reference_id"": ""PMID:9864311"", ""source_assertion"": ""GlcNAc uptake/phosphorylation can use NagE or the broad-specificity ManXYZ PTS. These alternatives must not be generalized to ManNAc: nagE and ptsG did not replace ManXYZ for that tested substrate."", ""source_locator"": ""PMC103530, Introduction and Results, Table 1""}]"	"[{""id"": ""MetaCyc:CPLX-167"", ""title"": ""N-acetylglucosamine-specific PTS enzyme II"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=CPLX-167""}, {""id"": ""PMID:9864311"", ""title"": ""Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9864311""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-072_f6d4f4727558	MetaCyc:CPLX-165	pathwaymech:catalyzes	RHEA:49241	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-165|PMID:9864311		"[{""reference_id"": ""MetaCyc:CPLX-165"", ""source_assertion"": ""Native catalyzes links include N-acetyl-D-glucosamine PTS permease activity. Transport phosphorylates incoming GlcNAc through the PTS relay; the Rhea histidyl-protein participants are formal generic states."", ""source_locator"": ""Protein/catalyzes/Enzymatic-Reaction""}, {""reference_id"": ""PMID:9864311"", ""source_assertion"": ""GlcNAc uptake/phosphorylation can use NagE or the broad-specificity ManXYZ PTS. These alternatives must not be generalized to ManNAc: nagE and ptsG did not replace ManXYZ for that tested substrate."", ""source_locator"": ""PMC103530, Introduction and Results, Table 1""}]"	"[{""id"": ""MetaCyc:CPLX-165"", ""title"": ""mannose-specific PTS enzyme II"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=CPLX-165""}, {""id"": ""PMID:9864311"", ""title"": ""Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9864311""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-073_840909811d74	MetaCyc:CPLX0-7938	pathwaymech:catalyzes	RHEA:23881	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08839		"[{""reference_id"": ""UniProtKB:P08839"", ""source_assertion"": ""Enzyme I transfers a phosphoryl group from PEP to HPr. The Rhea equation uses generic histidyl-protein states; the native enzyme is a homodimer and Mg2+-dependent."", ""source_locator"": ""comments[commentType=FUNCTION, SUBUNIT, COFACTOR]""}]"	"[{""id"": ""UniProtKB:P08839"", ""title"": ""Phosphoenolpyruvate-protein phosphotransferase"", ""url"": ""https://www.uniprot.org/uniprotkb/P08839""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-074_4168e5ee9a66	MetaCyc:CPLX-165	pathwaymech:enables	BiGG:ACMANAptspp	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	BiGG:ACMANAptspp		"[{""reference_id"": ""BiGG:ACMANAptspp"", ""source_assertion"": ""The exact MG1655 iML1515 gene rule requires ptsH b2415, ptsI b2416, manX b1817, manY b1818 and manZ b1819 for the coupled ManNAc PTS reaction. Native subunits/assemblies are grounded separately."", ""source_locator"": ""reactions[id=ACMANAptspp]/gene_reaction_rule; genes[id=b2415,b2416,b1817,b1818,b1819]""}]"	"[{""id"": ""BiGG:ACMANAptspp"", ""title"": ""N-acetyl-D-mannosamine transport via PTS  (periplasm)"", ""url"": ""https://bigg.ucsd.edu/universal/reactions/ACMANAptspp""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-075_e646b1e41f14	MetaCyc:CPLX0-7938	pathwaymech:enables	BiGG:ACMANAptspp	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	BiGG:ACMANAptspp		"[{""reference_id"": ""BiGG:ACMANAptspp"", ""source_assertion"": ""The exact MG1655 iML1515 gene rule requires ptsH b2415, ptsI b2416, manX b1817, manY b1818 and manZ b1819 for the coupled ManNAc PTS reaction. Native subunits/assemblies are grounded separately."", ""source_locator"": ""reactions[id=ACMANAptspp]/gene_reaction_rule; genes[id=b2415,b2416,b1817,b1818,b1819]""}]"	"[{""id"": ""BiGG:ACMANAptspp"", ""title"": ""N-acetyl-D-mannosamine transport via PTS  (periplasm)"", ""url"": ""https://bigg.ucsd.edu/universal/reactions/ACMANAptspp""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-076_795c4bc1aec3	MetaCyc:PTSH-MONOMER	pathwaymech:enables	BiGG:ACMANAptspp	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	BiGG:ACMANAptspp		"[{""reference_id"": ""BiGG:ACMANAptspp"", ""source_assertion"": ""The exact MG1655 iML1515 gene rule requires ptsH b2415, ptsI b2416, manX b1817, manY b1818 and manZ b1819 for the coupled ManNAc PTS reaction. Native subunits/assemblies are grounded separately."", ""source_locator"": ""reactions[id=ACMANAptspp]/gene_reaction_rule; genes[id=b2415,b2416,b1817,b1818,b1819]""}]"	"[{""id"": ""BiGG:ACMANAptspp"", ""title"": ""N-acetyl-D-mannosamine transport via PTS  (periplasm)"", ""url"": ""https://bigg.ucsd.edu/universal/reactions/ACMANAptspp""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-077_4bb4a896d22e	MetaCyc:PTSH-PHOSPHORYLATED	pathwaymech:enables	RHEA:49241	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PTSH-MONOMER		"[{""reference_id"": ""MetaCyc:PTSH-MONOMER"", ""source_assertion"": ""The native PTS relay transfers phosphate from enzyme I through HPr His15 and sugar-specific EII domains to the transported sugar; the phosphorylated HPr state is native PTSH-PHOSPHORYLATED."", ""source_locator"": ""Protein/comment; modified-form""}]"	"[{""id"": ""MetaCyc:PTSH-MONOMER"", ""title"": ""phosphocarrier protein HPr"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=PTSH-MONOMER""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-078_97b6b5f1b710	MetaCyc:CPLX0-7921	BFO:0000050	MetaCyc:GLCMANNANAUT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7921		"[{""reference_id"": ""MetaCyc:CPLX0-7921"", ""source_assertion"": ""ManX IIAB is separately represented as a homodimer; no direct has_part relation to a full ManXYZ assembly is inferred from the inconsistent granularity of the native complex frames."", ""source_locator"": ""Protein/component and common-name""}]"	"[{""id"": ""MetaCyc:CPLX0-7921"", ""title"": ""mannose-specific PTS enzyme IIAB component"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=CPLX0-7921""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-079_97d6490689dc	RHEA:67741	RO:0002413	RHEA:23297	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLCMANNANAUT-PWY|PMID:33895133		"[{""reference_id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""source_assertion"": ""The complete native degradation route orders these reactions; the alternative alpha ring-opening reaction is supported by the NanQ primary assays and converges on the same linear NanA substrate."", ""source_locator"": ""Pathway/reaction-ordering; child PWY0-1324 and GLUAMCAT-PWY reaction-ordering""}, {""reference_id"": ""PMID:33895133"", ""source_assertion"": ""The linear product of NanQ is the preferred NanA substrate; the supported alpha and beta inputs converge before downstream sugar catabolism."", ""source_locator"": ""PMC8141875, Results and Discussion""}]"	"[{""id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""title"": ""MetaCyc:GLCMANNANAUT-PWY"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=GLCMANNANAUT-PWY""}, {""id"": ""PMID:33895133"", ""title"": ""The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/33895133""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-080_e3e4db4322fb	RHEA:67737	RO:0002413	RHEA:23297	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLCMANNANAUT-PWY|PMID:33895133		"[{""reference_id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""source_assertion"": ""The complete native degradation route orders these reactions; the alternative alpha ring-opening reaction is supported by the NanQ primary assays and converges on the same linear NanA substrate."", ""source_locator"": ""Pathway/reaction-ordering; child PWY0-1324 and GLUAMCAT-PWY reaction-ordering""}, {""reference_id"": ""PMID:33895133"", ""source_assertion"": ""The linear product of NanQ is the preferred NanA substrate; the supported alpha and beta inputs converge before downstream sugar catabolism."", ""source_locator"": ""PMC8141875, Results and Discussion""}]"	"[{""id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""title"": ""MetaCyc:GLCMANNANAUT-PWY"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=GLCMANNANAUT-PWY""}, {""id"": ""PMID:33895133"", ""title"": ""The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/33895133""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-081_50e476efcd7a	RHEA:23297	RO:0002413	RHEA:25254	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLCMANNANAUT-PWY		"[{""reference_id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""source_assertion"": ""The complete native degradation route orders these reactions; the alternative alpha ring-opening reaction is supported by the NanQ primary assays and converges on the same linear NanA substrate."", ""source_locator"": ""Pathway/reaction-ordering; child reaction-ordering""}]"	"[{""id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""title"": ""MetaCyc:GLCMANNANAUT-PWY"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=GLCMANNANAUT-PWY""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-082_3d8e36dae93a	RHEA:25254	RO:0002413	RHEA:25259	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLCMANNANAUT-PWY		"[{""reference_id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""source_assertion"": ""The complete native degradation route orders these reactions; the alternative alpha ring-opening reaction is supported by the NanQ primary assays and converges on the same linear NanA substrate."", ""source_locator"": ""Pathway/reaction-ordering; child reaction-ordering""}]"	"[{""id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""title"": ""MetaCyc:GLCMANNANAUT-PWY"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=GLCMANNANAUT-PWY""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-083_de65a9806192	RHEA:25259	RO:0002413	RHEA:22937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLCMANNANAUT-PWY		"[{""reference_id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""source_assertion"": ""The complete native degradation route orders these reactions; the alternative alpha ring-opening reaction is supported by the NanQ primary assays and converges on the same linear NanA substrate."", ""source_locator"": ""Pathway/reaction-ordering; child reaction-ordering""}]"	"[{""id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""title"": ""MetaCyc:GLCMANNANAUT-PWY"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=GLCMANNANAUT-PWY""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-084_2219217273fe	RHEA:22937	RO:0002413	RHEA:12173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLCMANNANAUT-PWY		"[{""reference_id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""source_assertion"": ""The native reaction ordering and primary convergence route connect these steps. NagA produces anomer-unspecified GlcN6P whereas the directed NagB equation uses alpha-GlcN6P; this ordering does not equate those exact chemical identifiers."", ""source_locator"": ""Pathway/reaction-ordering; child reaction-ordering""}]"	"[{""id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""title"": ""MetaCyc:GLCMANNANAUT-PWY"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=GLCMANNANAUT-PWY""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-085_bb4573e48e92	RHEA:28989	RO:0002413	RHEA:67741	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33895133		"[{""reference_id"": ""PMID:33895133"", ""source_assertion"": ""Imported Neu5Ac supplies the cytosolic NanQ/NanA route. The transport equation pools anomers, while the native core specifies beta ring opening; this is pathway context, not an anomer-specific transport claim."", ""source_locator"": ""PMC8141875, Introduction, Results and Discussion; PMID:22167185 transport context""}]"	"[{""id"": ""PMID:33895133"", ""title"": ""The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/33895133""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-086_1b63eaea522d	BiGG:ACMANAptspp	RO:0002413	RHEA:25259	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	BiGG:acmanap|PMID:9864311		"[{""reference_id"": ""PMID:9864311"", ""source_assertion"": ""PTS uptake supplies ManNAc6P to NanE without the NanK ATP step. This physiological ordering does not independently determine the exact transported anomer or validate model structural cross-references."", ""source_locator"": ""PMC103530, Results and Discussion, convergence model Fig. 1""}, {""reference_id"": ""BiGG:acmanap"", ""source_assertion"": ""The native product has formula C8H14NO9P, charge -2 and InChIKey QDSLHWJDSQGPEE-WCTZXXKLSA-L. It is retained as its native model identity; the substrate annotation conflict is separately stated on the consumed model compound."", ""source_locator"": ""Universal metabolite formulae/charges/database_links[InChI Key]; iML1515/metabolites[id=acmanap_c]""}]"	"[{""id"": ""BiGG:acmanap"", ""title"": ""N-Acetyl-D-mannosamine 6-phosphate"", ""url"": ""https://bigg.ucsd.edu/models/universal/metabolites/acmanap""}, {""id"": ""PMID:9864311"", ""title"": ""Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9864311""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-087_8bb333672d48	RHEA:49241	RO:0002413	RHEA:22937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9864311		"[{""reference_id"": ""PMID:9864311"", ""source_assertion"": ""PTS-mediated GlcNAc uptake directly supplies GlcNAc6P, which NagA deacetylates before NagB deamination."", ""source_locator"": ""PMC103530, Fig. 1 and Introduction""}]"	"[{""id"": ""PMID:9864311"", ""title"": ""Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9864311""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-088_076361a78e40	RHEA:23881	RO:0002413	RHEA:49241	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08839		"[{""reference_id"": ""UniProtKB:P08839"", ""source_assertion"": ""Enzyme I supplies phosphorylated HPr to the sugar-specific PTS relay. This shared energy-transfer context overlaps the net BiGG ManNAc transport equation and is not an additional net stoichiometric input."", ""source_locator"": ""comments[commentType=FUNCTION]""}]"	"[{""id"": ""UniProtKB:P08839"", ""title"": ""Phosphoenolpyruvate-protein phosphotransferase"", ""url"": ""https://www.uniprot.org/uniprotkb/P08839""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-089_3908286f5ab0	RHEA:12173	RO:0002413	MetaCyc:GLYCOLYSIS	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLCMANNANAUT-PWY		"[{""reference_id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""source_assertion"": ""The native parent pathway-link connects FRUCTOSE-6P to GLYCOLYSIS. Only that downstream interface is represented, without importing the connected glycolysis network."", ""source_locator"": ""Pathway/pathway-link""}]"	"[{""id"": ""MetaCyc:GLCMANNANAUT-PWY"", ""title"": ""MetaCyc:GLCMANNANAUT-PWY"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=GLCMANNANAUT-PWY""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-090_437886cdfe6c	MetaCyc:NAG6PDEACET-CPLX	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:17567047		"[{""reference_id"": ""PMID:17567047"", ""source_assertion"": ""E. coli NagA uses one divalent metal per subunit. Reconstituted Zn, Co, Mn, Cd, Fe and Ni enzymes were active to different degrees; these are alternatives, not six simultaneously required metals. Zn and Co had the highest catalytic efficiencies."", ""source_locator"": ""PMC2533526, Results and Discussion S16/S17, Table 1; Methods S9/S10""}]"	"[{""id"": ""PMID:17567047"", ""title"": ""N-Acetyl-D-glucosamine-6-phosphate deacetylase: substrate activation via a single divalent metal ion."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/17567047""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-091_13873e58710b	MetaCyc:NAG6PDEACET-CPLX	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:17567047		"[{""reference_id"": ""PMID:17567047"", ""source_assertion"": ""E. coli NagA uses one divalent metal per subunit. Reconstituted Zn, Co, Mn, Cd, Fe and Ni enzymes were active to different degrees; these are alternatives, not six simultaneously required metals. Zn and Co had the highest catalytic efficiencies."", ""source_locator"": ""PMC2533526, Results and Discussion S16/S17, Table 1; Methods S9/S10""}]"	"[{""id"": ""PMID:17567047"", ""title"": ""N-Acetyl-D-glucosamine-6-phosphate deacetylase: substrate activation via a single divalent metal ion."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/17567047""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-092_88a21887af2f	MetaCyc:NAG6PDEACET-CPLX	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:17567047		"[{""reference_id"": ""PMID:17567047"", ""source_assertion"": ""E. coli NagA uses one divalent metal per subunit. Reconstituted Zn, Co, Mn, Cd, Fe and Ni enzymes were active to different degrees; these are alternatives, not six simultaneously required metals. Zn and Co had the highest catalytic efficiencies."", ""source_locator"": ""PMC2533526, Results and Discussion S16/S17, Table 1; Methods S9/S10""}]"	"[{""id"": ""PMID:17567047"", ""title"": ""N-Acetyl-D-glucosamine-6-phosphate deacetylase: substrate activation via a single divalent metal ion."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/17567047""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-093_64eb7efaacb2	MetaCyc:NAG6PDEACET-CPLX	pathwaymech:has_cofactor	CHEBI:48775	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:17567047		"[{""reference_id"": ""PMID:17567047"", ""source_assertion"": ""E. coli NagA uses one divalent metal per subunit. Reconstituted Zn, Co, Mn, Cd, Fe and Ni enzymes were active to different degrees; these are alternatives, not six simultaneously required metals. Zn and Co had the highest catalytic efficiencies."", ""source_locator"": ""PMC2533526, Results and Discussion S16/S17, Table 1; Methods S9/S10""}]"	"[{""id"": ""PMID:17567047"", ""title"": ""N-Acetyl-D-glucosamine-6-phosphate deacetylase: substrate activation via a single divalent metal ion."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/17567047""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-094_ca999923b810	MetaCyc:NAG6PDEACET-CPLX	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:17567047		"[{""reference_id"": ""PMID:17567047"", ""source_assertion"": ""E. coli NagA uses one divalent metal per subunit. Reconstituted Zn, Co, Mn, Cd, Fe and Ni enzymes were active to different degrees; these are alternatives, not six simultaneously required metals. Zn and Co had the highest catalytic efficiencies."", ""source_locator"": ""PMC2533526, Results and Discussion S16/S17, Table 1; Methods S9/S10""}]"	"[{""id"": ""PMID:17567047"", ""title"": ""N-Acetyl-D-glucosamine-6-phosphate deacetylase: substrate activation via a single divalent metal ion."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/17567047""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-095_4b487774e946	MetaCyc:NAG6PDEACET-CPLX	pathwaymech:has_cofactor	CHEBI:49786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:17567047		"[{""reference_id"": ""PMID:17567047"", ""source_assertion"": ""E. coli NagA uses one divalent metal per subunit. Reconstituted Zn, Co, Mn, Cd, Fe and Ni enzymes were active to different degrees; these are alternatives, not six simultaneously required metals. Zn and Co had the highest catalytic efficiencies."", ""source_locator"": ""PMC2533526, Results and Discussion S16/S17, Table 1; Methods S9/S10""}]"	"[{""id"": ""PMID:17567047"", ""title"": ""N-Acetyl-D-glucosamine-6-phosphate deacetylase: substrate activation via a single divalent metal ion."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/17567047""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-096_8933931787b5	UniProtKB:P45424	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P45424		"[{""reference_id"": ""UniProtKB:P45424"", ""source_assertion"": ""NanQ binds Zn2+; the proposed catalytic role is annotated with ECO:0000305, while Zn association is supported by PMID:33895133. Do not transfer the Zn-dependent interpretation to NanR."", ""source_locator"": ""comments[commentType=COFACTOR]""}]"	"[{""id"": ""UniProtKB:P45424"", ""title"": ""N-acetylneuraminate anomerase NanQ"", ""url"": ""https://www.uniprot.org/uniprotkb/P45424""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-097_e164726f084a	MetaCyc:CPLX0-7938	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08839		"[{""reference_id"": ""UniProtKB:P08839"", ""source_assertion"": ""Reviewed enzyme I cofactor annotation specifies Mg2+, supported by PMID:17053069."", ""source_locator"": ""comments[commentType=COFACTOR], ECO:0000269""}]"	"[{""id"": ""UniProtKB:P08839"", ""title"": ""Phosphoenolpyruvate-protein phosphotransferase"", ""url"": ""https://www.uniprot.org/uniprotkb/P08839""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-098_74574efa65bd	UniProtKB:P0A8W0	pathwaymech:inhibits	MetaCyc:PWY0-1324	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9864311		"[{""reference_id"": ""PMID:9864311"", ""source_assertion"": ""NanR represses the nanATEK-yhcH catabolic operon. The pathway-level edge denotes transcriptional control of those components, not direct inhibition of every chemical reaction."", ""source_locator"": ""PMC103530, Introduction, Results and Discussion""}]"	"[{""id"": ""PMID:9864311"", ""title"": ""Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9864311""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-099_969496d51a84	UniProtKB:P50456	pathwaymech:inhibits	MetaCyc:CPLX-165	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9864311		"[{""reference_id"": ""PMID:9864311"", ""source_assertion"": ""Mlc represses manXYZ expression; mlc loss increases transport capacity. The edge concerns transporter abundance, not direct catalytic inhibition."", ""source_locator"": ""PMC103530, Introduction, Results and Discussion""}]"	"[{""id"": ""PMID:9864311"", ""title"": ""Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9864311""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-100_dabe6ee8e4a2	UniProtKB:P0AF20	pathwaymech:inhibits	MetaCyc:GLUAMCAT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9864311		"[{""reference_id"": ""PMID:9864311"", ""source_assertion"": ""NagC represses nagE-nagBACD expression; intracellular GlcNAc6P is the inducing signal. The edge concerns expression, not direct inhibition of NagA or NagB."", ""source_locator"": ""PMC103530, Introduction, Results and Discussion""}]"	"[{""id"": ""PMID:9864311"", ""title"": ""Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9864311""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-101_22cae60fb031	CHEBI:35418	pathwaymech:inhibits	UniProtKB:P0A8W0	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33790291		"[{""reference_id"": ""PMID:33790291"", ""source_assertion"": ""Neu5Ac binding reduced NanR DNA affinity under the reported conditions. NanR remained dimeric with and without ligand; cooperative binding places three dimers on the three-repeat operator, contrary to the older ligand-induced monomerization interpretation."", ""source_locator"": ""PMC8012715, Results Sec4/Sec5/Sec6; Methods Sec12/Sec13""}]"	"[{""id"": ""PMID:33790291"", ""title"": ""PMID:33790291"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/33790291""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-102_aa80c808c502	CHEBI:57513	pathwaymech:inhibits	UniProtKB:P0AF20	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19700525		"[{""reference_id"": ""PMID:19700525"", ""source_assertion"": ""GlcNAc6P is the NagC inducing signal and increases nagE-nagBACD expression. Growth on GlcN provides only partial NagC induction from peptidoglycan recycling; native NagB can already be allosterically activated under those conditions."", ""source_locator"": ""PMC2753035, Abstract; Results and Discussion sec8/sec11""}]"	"[{""id"": ""PMID:19700525"", ""title"": ""PMID:19700525"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/19700525""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-103_782cf8169b47	CHEBI:57513	pathwaymech:activates	MetaCyc:GLUCOSAMINE-6-P-DEAMIN-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19700525		"[{""reference_id"": ""PMID:19700525"", ""source_assertion"": ""GlcNAc6P allosterically activates wild-type NagB; the reported in vivo growth experiments show substrate supply rather than additional allosteric activation can limit growth. This native mechanism is distinct from the Ser1 construct assays."", ""source_locator"": ""PMC2753035, Results and Discussion sec8/sec11""}]"	"[{""id"": ""PMID:19700525"", ""title"": ""PMID:19700525"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/19700525""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-104_62ba65310b87	CHEBI:58165	pathwaymech:activates	UniProtKB:P0ACJ8	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ACJ8		"[{""reference_id"": ""UniProtKB:P0ACJ8"", ""source_assertion"": ""cAMP allosterically activates DNA binding by CRP homodimers; binding-site annotations explicitly identify CHEBI:58165. This does not imply that every CRP target is transcriptionally activated."", ""source_locator"": ""comments[commentType=FUNCTION or SUBUNIT]; features[type=Binding site]/ligand""}]"	"[{""id"": ""UniProtKB:P0ACJ8"", ""title"": ""DNA-binding transcriptional dual regulator CRP"", ""url"": ""https://www.uniprot.org/uniprotkb/P0ACJ8""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-105_c1f87e75d3e3	EcoCyc:CPLX0-226	pathwaymech:regulates	MetaCyc:GLUAMCAT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-226|MetaCyc:CPLX-167|PMID:7791215		"[{""reference_id"": ""MetaCyc:CPLX-167"", ""source_assertion"": ""The native NagE description names regulation by NagC together with the cAMP-CRP complex. This edge preserves promoter-regulation context without assigning a universal positive sign."", ""source_locator"": ""Protein/comment, paragraph beginning Expression of the nagE monocistronic operon""}, {""reference_id"": ""PMID:7791215"", ""source_assertion"": ""The primary abstract reports cAMP/CAP effects on NagC apparent binding to wild-type versus super-operators. Full text was not inspected; no additional promoter-architecture result is inferred."", ""source_locator"": ""Issuing Europe PMC primary abstract""}, {""reference_id"": ""EcoCyc:CPLX0-226"", ""source_assertion"": ""The exact cAMP-bound CRP complex is issued in ECOLI 27.0 for K-12 substr. MG1655 (NCBITaxon:511145). Native nagEp regulations have both signs; this contextual Nag edge remains unsigned."", ""source_locator"": ""Protein/common-name; metadata/PGDB; regulated promoter nagEp and modes""}]"	"[{""id"": ""EcoCyc:CPLX0-226"", ""title"": ""CRP-cyclic-AMP DNA-binding transcriptional dual regulator (ECOLI 27.0; MG1655)"", ""url"": ""https://ecocyc.org/ECOLI/NEW-IMAGE?object=CPLX0-226""}, {""id"": ""MetaCyc:CPLX-167"", ""title"": ""N-acetylglucosamine-specific PTS enzyme II"", ""url"": ""https://biocyc.org/META/NEW-IMAGE?object=CPLX-167""}, {""id"": ""PMID:7791215"", ""title"": ""Nag repressor-operator interactions: protein-DNA contacts cover more than two turns of the DNA helix."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/7791215""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-106_51cf7726b38d	UniProtKB:P0AF20	pathwaymech:regulates	MetaCyc:CPLX-165	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:7791215		"[{""reference_id"": ""PMID:7791215"", ""source_assertion"": ""The primary abstract reports NagC binding at two sites upstream of manXYZ. This is promoter-regulatory context without an inferred magnitude or universal direction of expression change."", ""source_locator"": ""Issuing Europe PMC primary abstract""}]"	"[{""id"": ""PMID:7791215"", ""title"": ""Nag repressor-operator interactions: protein-DNA contacts cover more than two turns of the DNA helix."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/7791215""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-107_dbfa11b08f19	MetaCyc:URIDYLYL-PII	pathwaymech:activates	UniProtKB:P0A759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:29229699		"[{""reference_id"": ""PMID:29229699"", ""source_assertion"": ""Uridylylated PII increased Ser1-NagB activity in the presence of GlcNAc6P; magnitude depended on modification, pH and substrate conditions. GlnD-only mixture controls did not explain activation. No exact modified-trimer occupancy is inferred."", ""source_locator"": ""PMC5809692, Results sec2-1/sec2-2; Methods sec4-3/sec4-6""}]"	"[{""id"": ""PMID:29229699"", ""title"": ""The Nitrogen Regulatory PII Protein (GlnB) and N-Acetylglucosamine 6-Phosphate Epimerase (NanE) Allosterically Activate Glucosamine 6-Phosphate Deaminase (NagB) in Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/29229699""}]"	"[{""description"": ""His-tagged ASKA GlnB, refolded and uridylylated with GlnD. Partial and fully modified preparations were compared; U-PII was not repurified from the uridylylation mixture."", ""endpoint"": ""subject"", ""evidence"": [{""reference_id"": ""PMID:29229699"", ""source_assertion"": ""The study identifies the recombinant preparation and its construct/purification scope; this qualification restricts the endpoint to that assay material."", ""source_locator"": ""PMC5809692, Materials and Methods sec4-3/sec4-6""}], ""kind"": ""experimental_construct""}, {""description"": ""Ser1-NagB from E. coli BW25113: first nagB codon omitted in a SUMO fusion; Ulp1 cleavage yields N-terminal Ser instead of native Met. No sequence equivalence elsewhere is asserted."", ""endpoint"": ""object"", ""evidence"": [{""reference_id"": ""PMID:29229699"", ""source_assertion"": ""The study identifies the recombinant preparation and its construct/purification scope; this qualification restricts the endpoint to that assay material."", ""source_locator"": ""PMC5809692, Materials and Methods sec4-2/sec4-5""}], ""kind"": ""experimental_construct""}]"
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-108_7bfba9fe5dc5	UniProtKB:P0A761	pathwaymech:activates	UniProtKB:P0A759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:29229699		"[{""reference_id"": ""PMID:29229699"", ""source_assertion"": ""NanE activated Ser1-NagB with or without GlcNAc6P. At 0.7 micromolar NanE, effects depended on pH and substrate conditions. This regulatory assay does not independently establish purified K-12 NanE epimerase chemistry."", ""source_locator"": ""PMC5809692, Results sec2-1/sec2-3; Methods sec4-3/sec4-5""}]"	"[{""id"": ""PMID:29229699"", ""title"": ""The Nitrogen Regulatory PII Protein (GlnB) and N-Acetylglucosamine 6-Phosphate Epimerase (NanE) Allosterically Activate Glucosamine 6-Phosphate Deaminase (NagB) in Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/29229699""}]"	"[{""description"": ""His-tagged recombinant ASKA NanE preparation, purified by Ni2+-chelating chromatography."", ""endpoint"": ""subject"", ""evidence"": [{""reference_id"": ""PMID:29229699"", ""source_assertion"": ""The study identifies the recombinant preparation and its construct/purification scope; this qualification restricts the endpoint to that assay material."", ""source_locator"": ""PMC5809692, Materials and Methods sec4-3/sec4-6""}], ""kind"": ""experimental_construct""}, {""description"": ""Ser1-NagB from E. coli BW25113: first nagB codon omitted in a SUMO fusion; Ulp1 cleavage yields N-terminal Ser instead of native Met. No sequence equivalence elsewhere is asserted."", ""endpoint"": ""object"", ""evidence"": [{""reference_id"": ""PMID:29229699"", ""source_assertion"": ""The study identifies the recombinant preparation and its construct/purification scope; this qualification restricts the endpoint to that assay material."", ""source_locator"": ""PMC5809692, Materials and Methods sec4-2/sec4-5""}], ""kind"": ""experimental_construct""}]"
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-109_f1c4eff646e4	MetaCyc:PTSH-MONOMER	pathwaymech:activates	UniProtKB:P0A759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:28634232|PMID:29229699		"[{""reference_id"": ""PMID:29229699"", ""source_assertion"": ""Nonphosphorylated HPr enhanced Ser1-NagB activity in the reported GlcNAc6P-dependent assays. HPr plus U-PII or NanE showed conditional synergy; docking models do not establish a new physical multi-protein complex."", ""source_locator"": ""PMC5809692, Results sec2-1/sec2-4 and Fig. 5""}]"	"[{""id"": ""PMID:28634232"", ""title"": ""PMID:28634232"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/28634232""}, {""id"": ""PMID:29229699"", ""title"": ""The Nitrogen Regulatory PII Protein (GlnB) and N-Acetylglucosamine 6-Phosphate Epimerase (NanE) Allosterically Activate Glucosamine 6-Phosphate Deaminase (NagB) in Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/29229699""}]"	"[{""description"": ""Recombinant HPr assay preparation in its nonphosphorylated state; the earlier study identifies an ASKA His-tagged preparation."", ""endpoint"": ""subject"", ""evidence"": [{""reference_id"": ""PMID:28634232"", ""source_assertion"": ""The earlier study purified ASKA HPr with an N-terminal His6 tag."", ""source_locator"": ""PMC5572926, Experimental procedures sec9/sec10""}], ""kind"": ""experimental_construct""}, {""description"": ""Ser1-NagB from E. coli BW25113: first nagB codon omitted in a SUMO fusion; Ulp1 cleavage yields N-terminal Ser instead of native Met. No sequence equivalence elsewhere is asserted."", ""endpoint"": ""object"", ""evidence"": [{""reference_id"": ""PMID:29229699"", ""source_assertion"": ""The study identifies the recombinant preparation and its construct/purification scope; this qualification restricts the endpoint to that assay material."", ""source_locator"": ""PMC5809692, Materials and Methods sec4-2/sec4-5""}], ""kind"": ""experimental_construct""}]"
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-110_87010ad61ae3	EcoCyc:CPLX0-226	pathwaymech:activates	MetaCyc:CPLX-165	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-226|PMID:9484892		"[{""reference_id"": ""EcoCyc:CPLX0-226"", ""source_assertion"": ""ECOLI 27.0 MG1655 regulations REG0-5729 and REG0-5728 positively regulate manXp with the cAMP-bound CRP complex. This edge concerns ManXYZ expression, not direct stimulation of assembled transporter catalysis."", ""source_locator"": ""Protein/regulates/Regulation[@frameid=REG0-5729]; nested regulated-entity/Promoter/regulated-by/Regulation[@frameid=REG0-5728]; mode, regulator and manXp PM00276""}, {""reference_id"": ""PMID:9484892"", ""source_assertion"": ""The primary abstract reports cAMP/CAP-dependent manX transcription and class II promoter activation. Full article methods and experimental strain details were not inspected; no universal amino-sugar growth-condition effect is inferred."", ""source_locator"": ""Europe PMC exact MED result, abstractText""}]"	"[{""id"": ""EcoCyc:CPLX0-226"", ""title"": ""CRP-cyclic-AMP DNA-binding transcriptional dual regulator (ECOLI 27.0; MG1655)"", ""url"": ""https://ecocyc.org/ECOLI/NEW-IMAGE?object=CPLX0-226""}, {""id"": ""PMID:9484892"", ""title"": ""Control of the expression of the manXYZ operon in Escherichia coli: Mlc is a negative regulator of the mannose PTS."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9484892""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-111_a2ec21f4938b	EcoCyc:RNA0-241	pathwaymech:inhibits	MetaCyc:CPLX-165	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:RNA0-241|PMID:22988087		"[{""reference_id"": ""PMID:22988087"", ""source_assertion"": ""SgrS represses ManXYZ synthesis through two manXYZ mRNA binding sites: the manX coding site and the manX-manY intergenic site independently control manX and manYZ translation. manZ is coupled to manY; both sites support efficient message degradation and full 2DG-stress recovery. This is not direct inhibition of assembled transport or an SgrT protein effect."", ""source_locator"": ""PMC3479541, Results sec2-sec8, Discussion s2; Figs. 1-7""}, {""reference_id"": ""PMID:22988087"", ""source_assertion"": ""Reporter, binding-site mutant, RNase E mutant, footprinting and stress-growth assays support the mechanism. Main-text methods name CS104/JH derivatives and DJ480; Table S1 was not inspected. These assay backgrounds are not all asserted to be unmodified MG1655 or identical to the native SgrS sequence."", ""source_locator"": ""PMC3479541, Materials and Methods s3/sec11-sec16; Figs. 1-6""}, {""reference_id"": ""EcoCyc:RNA0-241"", ""source_assertion"": ""The native ECOLI 27.0 MG1655 record identifies the regulatory RNA SgrS, aliases SgrS/RyaA, distinct from its G0-9941 gene and the SgrT protein. Its first comment paragraph cites Rice12 for independent manX and manYZ translational repression."", ""source_locator"": ""RNA/common-name, synonym, gene; metadata/PGDB; RNA/comment paragraph1""}]"	"[{""id"": ""EcoCyc:RNA0-241"", ""title"": ""small regulatory RNA SgrS (ECOLI 27.0; MG1655)"", ""url"": ""https://ecocyc.org/ECOLI/NEW-IMAGE?object=RNA0-241""}, {""id"": ""PMID:22988087"", ""title"": ""Small RNA binding-site multiplicity involved in translational regulation of a polycistronic mRNA."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/22988087""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-112_abd597b84a53	EcoCyc:CPLX0-226	BFO:0000051	EcoCyc:PC00004	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-226		"[{""reference_id"": ""EcoCyc:CPLX0-226"", ""source_assertion"": ""The ECOLI 27.0 MG1655 cAMP-bound complex explicitly contains protein complex PC00004 and compound CAMP. No component coefficient is supplied here; no bound-complex occupancy or numerical stoichiometry is inferred."", ""source_locator"": ""Protein/component/Protein[@frameid=PC00004]; component/Compound[@frameid=CAMP]""}]"	"[{""id"": ""EcoCyc:CPLX0-226"", ""title"": ""CRP-cyclic-AMP DNA-binding transcriptional dual regulator (ECOLI 27.0; MG1655)"", ""url"": ""https://ecocyc.org/ECOLI/NEW-IMAGE?object=CPLX0-226""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-113_11854205d79d	EcoCyc:CPLX0-226	BFO:0000051	CHEBI:58165	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CAMP|EcoCyc:CPLX0-226		"[{""reference_id"": ""EcoCyc:CPLX0-226"", ""source_assertion"": ""CAMP is an explicit component of the native cAMP-bound CRP complex; its component coefficient is absent. This records composition without asserting cAMP occupancy."", ""source_locator"": ""Protein/component/Compound[@frameid=CAMP]""}, {""reference_id"": ""EcoCyc:CAMP"", ""source_assertion"": ""The exact ECOLI CAMP compound has a CHEBI58165 unification link and a charged InChI matching the issuing ChEBI compound. Its identity is distinct from any inferred binding occupancy."", ""source_locator"": ""Compound/dblink[dblink-db=CHEBI]; Compound/inchi""}]"	"[{""id"": ""EcoCyc:CAMP"", ""title"": ""cyclic-AMP native identity and ChEBI unification (ECOLI 27.0; MG1655)"", ""url"": ""https://ecocyc.org/ECOLI/NEW-IMAGE?object=CAMP""}, {""id"": ""EcoCyc:CPLX0-226"", ""title"": ""CRP-cyclic-AMP DNA-binding transcriptional dual regulator (ECOLI 27.0; MG1655)"", ""url"": ""https://ecocyc.org/ECOLI/NEW-IMAGE?object=CPLX0-226""}]"	""
pathwaymech:MetaCyc_GLCMANNANAUT-PWY_amino-114_a019bac81fb7	EcoCyc:PC00004	BFO:0000051	UniProtKB:P0ACJ8	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:PC00004|EcoCyc:PD00257		"[{""reference_id"": ""EcoCyc:PC00004"", ""source_assertion"": ""The ECOLI 27.0 MG1655 CRP protein complex contains component PD00257 with coefficient 2. This establishes the protein homodimer, without inferring a cAMP coefficient for the separately named bound complex."", ""source_locator"": ""Protein/component/Protein[@frameid=PD00257]; component/coefficient""}, {""reference_id"": ""EcoCyc:PD00257"", ""source_assertion"": ""The exact ECOLI polypeptide PD00257 has a native UniProt P0ACJ8 unification link. Native MG1655 provenance and the reviewed K-12 UniProt sequence scope remain distinct."", ""source_locator"": ""Protein/dblink[dblink-db=UNIPROT][dblink-relationship=unification]""}]"	"[{""id"": ""EcoCyc:PC00004"", ""title"": ""DNA-binding transcriptional dual regulator CRP (ECOLI 27.0; MG1655)"", ""url"": ""https://ecocyc.org/ECOLI/NEW-IMAGE?object=PC00004""}, {""id"": ""EcoCyc:PD00257"", ""title"": ""CRP polypeptide native identity and UniProt unification (ECOLI 27.0; MG1655)"", ""url"": ""https://ecocyc.org/ECOLI/NEW-IMAGE?object=PD00257""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-001_ef2b3f810e5a	gomodel:ASPAMINOTRANS-RXN	RO:0002234	CHEBI:29991	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002234 gomodel:CHEBI_29991_ASPAMINOTRANS-RXN."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/0; endpoint types: /individuals/0/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-002_736487ed6c5c	gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248	RO:0002233	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248 RO:0002233 gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002250."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/1; endpoint types: /individuals/32/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-003_5ae5822454c4	gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002268	RO:0002233	CHEBI:16452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002268 RO:0002233 gomodel:CHEBI_16452_PYRUVATE-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/2; endpoint types: /individuals/51/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-004_f052a5f93937	gomodel:PYRUVATE-CARBOXYLASE-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_456216_PYRUVATE-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/3; endpoint types: /individuals/11/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-005_940380dbcb4f	gomodel:PYRUVATE-CARBOXYLASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_15378_PYRUVATE-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/4; endpoint types: /individuals/11/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-006_3486b17e92c1	gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248 RO:0002234 gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002254."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/5; endpoint types: /individuals/32/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-007_7a7b57d09183	gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002268	BFO:0000050	GO:0006532	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002268 BFO:0000050 gomodel:YeastPathways_ASPBIO-PWY/YeastPathways_ASPBIO-PWY."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/6; endpoint types: /individuals/51/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-008_f30110eb5325	gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248 RO:0002234 gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002253."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/7; endpoint types: /individuals/32/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-009_ce79143c3fc3	gomodel:ASPAMINOTRANS-RXN	RO:0002233	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002233 gomodel:CHEBI_29985_ASPAMINOTRANS-RXN."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/8; endpoint types: /individuals/0/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-010_35bc32b259bb	gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002268	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002268 BFO:0000066 gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002274."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/9; endpoint types: /individuals/51/type; /individuals/56/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-011_ec101f1b55a0	gomodel:PYRUVATE-CARBOXYLASE-RXN	BFO:0000050	GO:0006532	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN BFO:0000050 gomodel:YeastPathways_ASPBIO-PWY/YeastPathways_ASPBIO-PWY."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/10; endpoint types: /individuals/11/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-013_c8575b6df3b5	SGD:S000004017	pathwaymech:enables	gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002268	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002268 RO:0002333 gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002272."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/12; endpoint types: /individuals/51/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-014_a676e014ce9a	gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002268	RO:0002234	CHEBI:29991	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002268 RO:0002234 gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002270."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/13; endpoint types: /individuals/51/type; /individuals/53/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-015_1131ad912ad1	gomodel:PYRUVATE-CARBOXYLASE-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_43474_PYRUVATE-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/14; endpoint types: /individuals/11/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-016_d24e66fa36e6	gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248	RO:0002233	CHEBI:17544	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248 RO:0002233 gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002249."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/15; endpoint types: /individuals/32/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-017_2ff55d8613ab	SGD:S000001589	pathwaymech:enables	gomodel:ASPAMINOTRANS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002333 gomodel:YKL106W-MONOMER_ASPAMINOTRANS-RXN_controller."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/16; endpoint types: /individuals/0/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-018_1aa347ccc152	gomodel:ASPAMINOTRANS-RXN	BFO:0000050	GO:0006532	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN BFO:0000050 gomodel:YeastPathways_ASPBIO-PWY/YeastPathways_ASPBIO-PWY."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/17; endpoint types: /individuals/0/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-019_d54b3ceab4a8	gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248 RO:0002233 gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002251."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/18; endpoint types: /individuals/32/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-020_abe07f8eb84a	gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248 BFO:0000066 gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002257."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/19; endpoint types: /individuals/32/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-021_cdd24f06d30d	gomodel:PYRUVATE-CARBOXYLASE-RXN	RO:0002233	CHEBI:17544	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002233 gomodel:CHEBI_17544_PYRUVATE-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/20; endpoint types: /individuals/11/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-022_e975e57c06da	gomodel:ASPAMINOTRANS-RXN	RO:0002234	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002234 gomodel:CHEBI_16810_ASPAMINOTRANS-RXN."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/21; endpoint types: /individuals/0/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-023_bc7196983b4f	SGD:S000003030	pathwaymech:enables	gomodel:PYRUVATE-CARBOXYLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002333 gomodel:YGL062W-MONOMER_PYRUVATE-CARBOXYLASE-RXN_controller."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/22; endpoint types: /individuals/11/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-024_a0d508400e17	gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248 RO:0002234 gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002252."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/23; endpoint types: /individuals/32/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-025_a50b7d289002	SGD:S000000422	pathwaymech:enables	gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248 RO:0002333 gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002255."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/24; endpoint types: /individuals/32/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-026_68b44b5f563b	gomodel:PYRUVATE-CARBOXYLASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN BFO:0000066 gomodel:reaction_PYRUVATE-CARBOXYLASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/25; endpoint types: /individuals/11/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-027_d29e3dee3f0a	gomodel:PYRUVATE-CARBOXYLASE-RXN	RO:0002233	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002233 gomodel:CHEBI_15361_PYRUVATE-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/26; endpoint types: /individuals/11/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-028_3abb6ce69c11	gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248	BFO:0000050	GO:0006532	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248 BFO:0000050 gomodel:YeastPathways_ASPBIO-PWY/YeastPathways_ASPBIO-PWY."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/27; endpoint types: /individuals/32/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-029_65b16809f4d4	gomodel:ASPAMINOTRANS-RXN	RO:0002233	CHEBI:16452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002233 gomodel:CHEBI_16452_PYRUVATE-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/28; endpoint types: /individuals/0/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-030_6efa7e5d5d9a	gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248	RO:0002234	CHEBI:16452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002248 RO:0002234 gomodel:CHEBI_16452_PYRUVATE-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/29; endpoint types: /individuals/32/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-031_f232f1ceac3c	gomodel:PYRUVATE-CARBOXYLASE-RXN	RO:0002234	CHEBI:16452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_16452_PYRUVATE-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/30; endpoint types: /individuals/11/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-032_504c87bbbea9	gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002268	RO:0002234	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002268 RO:0002234 gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002271."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/31; endpoint types: /individuals/51/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-033_fd50f20d5321	gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002268	RO:0002233	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002268 RO:0002233 gomodel:YeastPathways_ASPBIO-PWY/6a4c244800002269."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/32; endpoint types: /individuals/51/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_edge-034_8b3d0e236ec1	gomodel:PYRUVATE-CARBOXYLASE-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPBIO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002233 gomodel:CHEBI_30616_PYRUVATE-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_ASPBIO-PWY.json#/facts/33; endpoint types: /individuals/11/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPBIO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPBIO-PWY.json"", ""title"": ""GO-CAM aspartate biosynthesis model YeastPathways_ASPBIO-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_location-1e7bf32ae78a_402fa583af6b	SGD:S000004017	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23542	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:9288922) Source qualification: Targeted to peroxisomes in cells grown in oleate	"[{""reference_id"": ""UniProtKB:P23542"", ""source_assertion"": ""UniProtKB:P23542 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/619/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P23542"", ""source_assertion"": ""UniProtKB:P23542 has the exact SGD cross-reference SGD:S000004017."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/619/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P23542"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P23542 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_location-6a637403e389_df44f9cc621c	SGD:S000004017	RO:0001025	GO:0005777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23542	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:9288922) Source qualification: Targeted to peroxisomes in cells grown in oleate	"[{""reference_id"": ""UniProtKB:P23542"", ""source_assertion"": ""UniProtKB:P23542 annotates location Peroxisome (SL-0204)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/619/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P23542"", ""source_assertion"": ""UniProtKB:P23542 has the exact SGD cross-reference SGD:S000004017."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/619/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P23542"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P23542 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_location-6e825fa767f7_2629d5e4c75b	SGD:S000001589	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q01802	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:14576278)	"[{""reference_id"": ""UniProtKB:Q01802"", ""source_assertion"": ""UniProtKB:Q01802 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4042/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q01802"", ""source_assertion"": ""UniProtKB:Q01802 has the exact SGD cross-reference SGD:S000001589."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4042/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q01802"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q01802 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_location-addfaa29f6ad_4f9ff413a88f	SGD:S000003030	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P11154	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P11154"", ""source_assertion"": ""UniProtKB:P11154 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/322/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P11154"", ""source_assertion"": ""UniProtKB:P11154 has the exact SGD cross-reference SGD:S000003030."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/322/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P11154"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P11154 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_location-900428dafe53_eeb34609b7d5	SGD:S000000422	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32327	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P32327"", ""source_assertion"": ""UniProtKB:P32327 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/866/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32327"", ""source_assertion"": ""UniProtKB:P32327 has the exact SGD cross-reference SGD:S000000422."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/866/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32327"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32327 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_cofactor-decdaaabf93f_a90f4ef26b2e	SGD:S000004017	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23542	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:6811576); ECO:0000269 (PubMed:9655342)	"[{""reference_id"": ""UniProtKB:P23542"", ""source_assertion"": ""UniProtKB:P23542 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/619/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P23542"", ""source_assertion"": ""UniProtKB:P23542 has the exact SGD cross-reference SGD:S000004017."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/619/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P23542"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P23542 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_cofactor-8644f9391497_fe8d0ec2a6b3	SGD:S000001589	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q01802	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:Q01802"", ""source_assertion"": ""UniProtKB:Q01802 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4042/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:Q01802"", ""source_assertion"": ""UniProtKB:Q01802 has the exact SGD cross-reference SGD:S000001589."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4042/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q01802"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q01802 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_cofactor-3a9b45fb14f3_370a016bbefc	SGD:S000003030	pathwaymech:has_cofactor	CHEBI:57586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P11154	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P11154"", ""source_assertion"": ""UniProtKB:P11154 annotates CHEBI:57586 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/322/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P11154"", ""source_assertion"": ""UniProtKB:P11154 has the exact SGD cross-reference SGD:S000003030."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/322/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P11154"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P11154 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_cofactor-9d5cb52383e9_ea917cefc508	SGD:S000003030	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P11154	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P11154"", ""source_assertion"": ""UniProtKB:P11154 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/322/comments/1/cofactors/0""}, {""reference_id"": ""UniProtKB:P11154"", ""source_assertion"": ""UniProtKB:P11154 has the exact SGD cross-reference SGD:S000003030."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/322/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P11154"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P11154 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_cofactor-ea39fb0d9a18_c2d485eb8e27	SGD:S000000422	pathwaymech:has_cofactor	CHEBI:57586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32327	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P32327"", ""source_assertion"": ""UniProtKB:P32327 annotates CHEBI:57586 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/866/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P32327"", ""source_assertion"": ""UniProtKB:P32327 has the exact SGD cross-reference SGD:S000000422."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/866/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32327"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32327 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPBIO-PWY_cofactor-4a3243df50b7_cf1c6d9ef596	SGD:S000000422	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32327	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P32327"", ""source_assertion"": ""UniProtKB:P32327 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/866/comments/1/cofactors/0""}, {""reference_id"": ""UniProtKB:P32327"", ""source_assertion"": ""UniProtKB:P32327 has the exact SGD cross-reference SGD:S000000422."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/866/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32327"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32327 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-001_c3c89ab7eb38	gomodel:SULFITE-REDUCT-RXN	RO:0002234	CHEBI:16136	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:SULFITE-REDUCT-RXN RO:0002234 gomodel:CHEBI_16136_SULFITE-REDUCT-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/0; endpoint types: /individuals/22/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-002_74cb9e5f888b	SGD:S000001484	pathwaymech:enables	gomodel:ADENYLYLSULFKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:ADENYLYLSULFKIN-RXN RO:0002333 gomodel:YKL001C-MONOMER_ADENYLYLSULFKIN-RXN_controller."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/1; endpoint types: /individuals/0/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-003_e56810da6c06	gomodel:SULFITE-REDUCT-RXN	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:SULFITE-REDUCT-RXN RO:0002233 gomodel:CHEBI_57783_SULFITE-REDUCT-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/2; endpoint types: /individuals/22/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-004_e016fad9b834	gomodel:SULFITE-REDUCT-RXN	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:SULFITE-REDUCT-RXN RO:0002234 gomodel:CHEBI_15377_SULFITE-REDUCT-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/3; endpoint types: /individuals/22/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-005_f98dd0293def	gomodel:ADENYLYLSULFKIN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:ADENYLYLSULFKIN-RXN RO:0002234 gomodel:CHEBI_15378_ADENYLYLSULFKIN-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/4; endpoint types: /individuals/0/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-006_89030f1d3340	SGD:S000003771	pathwaymech:enables	gomodel:SULFATE-ADENYLYLTRANS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:SULFATE-ADENYLYLTRANS-RXN RO:0002333 gomodel:YJR010W-MONOMER_SULFATE-ADENYLYLTRANS-RXN_controller."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/5; endpoint types: /individuals/21/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-007_ee81223de4ab	gomodel:1.8.4.8-RXN	RO:0002234	CHEBI:17359	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:1.8.4.8-RXN RO:0002234 gomodel:CHEBI_17359_1.8.4.8-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/6; endpoint types: /individuals/60/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-008_5392e0955979	gomodel:1.8.4.8-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:1.8.4.8-RXN BFO:0000066 gomodel:reaction_1.8.4.8-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/7; endpoint types: /individuals/60/type; /individuals/56/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-009_2f33d6aa5a9c	gomodel:SULFATE-ADENYLYLTRANS-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:SULFATE-ADENYLYLTRANS-RXN RO:0002233 gomodel:CHEBI_15378_SULFATE-ADENYLYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/8; endpoint types: /individuals/21/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-010_54ed2e7e0712	gomodel:1.8.4.8-RXN	BFO:0000050	GO:0000103	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:1.8.4.8-RXN BFO:0000050 gomodel:YeastPathways_SO4ASSIM-PWY/YeastPathways_SO4ASSIM-PWY."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/9; endpoint types: /individuals/60/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-011_970a5dbf7883	gomodel:SULFATE-ADENYLYLTRANS-RXN	RO:0002413	gomodel:ADENYLYLSULFKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:SULFATE-ADENYLYLTRANS-RXN RO:0002413 gomodel:ADENYLYLSULFKIN-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/10; endpoint types: /individuals/21/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-012_0bed5cfde379	gomodel:1.8.4.8-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:1.8.4.8-RXN RO:0002234 gomodel:CHEBI_15378_1.8.4.8-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/11; endpoint types: /individuals/60/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-013_d65bdb711c29	gomodel:SULFITE-REDUCT-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:SULFITE-REDUCT-RXN BFO:0000066 gomodel:reaction_SULFITE-REDUCT-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/12; endpoint types: /individuals/22/type; /individuals/59/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-014_f98f539eb7fd	SGD:S000217821	pathwaymech:enables	gomodel:SULFITE-REDUCT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:SULFITE-REDUCT-RXN RO:0002333 gomodel:CPLX3O-23_SULFITE-REDUCT-RXN_controller."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/13; endpoint types: /individuals/22/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-015_fdff685ba582	gomodel:SULFITE-REDUCT-RXN	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:SULFITE-REDUCT-RXN RO:0002234 gomodel:CHEBI_58349_SULFITE-REDUCT-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/14; endpoint types: /individuals/22/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-016_cc8b436533ec	gomodel:ADENYLYLSULFKIN-RXN	RO:0002413	gomodel:1.8.4.8-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:ADENYLYLSULFKIN-RXN RO:0002413 gomodel:1.8.4.8-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/15; endpoint types: /individuals/0/type; /individuals/60/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-017_f93e9a9ca03f	gomodel:SULFATE-ADENYLYLTRANS-RXN	RO:0002234	CHEBI:58243	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:SULFATE-ADENYLYLTRANS-RXN RO:0002234 gomodel:CHEBI_58243_SULFATE-ADENYLYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/16; endpoint types: /individuals/21/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-018_e168c182938e	SGD:S000217821	BFO:0000051	SGD:S000001926	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:CPLX3O-23_SULFITE-REDUCT-RXN_controller BFO:0000051 gomodel:SGD_S000001926_CPLX3O-23_component."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/17; endpoint types: /individuals/18/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-019_4872fa59ecc5	gomodel:SULFITE-REDUCT-RXN	RO:0002233	CHEBI:17359	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:SULFITE-REDUCT-RXN RO:0002233 gomodel:CHEBI_17359_1.8.4.8-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/18; endpoint types: /individuals/22/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-020_ca630dc91712	gomodel:1.8.4.8-RXN	RO:0002233	CHEBI:15033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:1.8.4.8-RXN RO:0002233 gomodel:YeastPathways_SO4ASSIM-PWY/6a4c244800003900."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/19; endpoint types: /individuals/60/type; /individuals/62/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-021_35d107538eef	gomodel:SULFATE-ADENYLYLTRANS-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:SULFATE-ADENYLYLTRANS-RXN BFO:0000066 gomodel:reaction_SULFATE-ADENYLYLTRANS-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/20; endpoint types: /individuals/21/type; /individuals/58/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-022_6d1a9a288564	gomodel:1.8.4.8-RXN	RO:0002234	CHEBI:58343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:1.8.4.8-RXN RO:0002234 gomodel:CHEBI_58343_1.8.4.8-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/21; endpoint types: /individuals/60/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-023_ecb71d11e6b6	gomodel:SULFATE-ADENYLYLTRANS-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:SULFATE-ADENYLYLTRANS-RXN RO:0002233 gomodel:CHEBI_30616_SULFATE-ADENYLYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/22; endpoint types: /individuals/21/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-024_a4387f8f3faf	gomodel:1.8.4.8-RXN	RO:0002234	CHEBI:15033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:1.8.4.8-RXN RO:0002234 gomodel:YeastPathways_SO4ASSIM-PWY/6a4c244800003901."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/23; endpoint types: /individuals/60/type; /individuals/63/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-025_bf86947adf08	gomodel:ADENYLYLSULFKIN-RXN	RO:0002234	CHEBI:58339	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:ADENYLYLSULFKIN-RXN RO:0002234 gomodel:CHEBI_58339_ADENYLYLSULFKIN-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/24; endpoint types: /individuals/0/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-026_8e738ce53ea3	gomodel:ADENYLYLSULFKIN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:ADENYLYLSULFKIN-RXN BFO:0000066 gomodel:reaction_ADENYLYLSULFKIN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/25; endpoint types: /individuals/0/type; /individuals/57/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-027_de9b469d1c49	gomodel:ADENYLYLSULFKIN-RXN	RO:0002233	CHEBI:58243	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:ADENYLYLSULFKIN-RXN RO:0002233 gomodel:CHEBI_58243_SULFATE-ADENYLYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/26; endpoint types: /individuals/0/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-028_0e5c71097315	SGD:S000217821	BFO:0000051	SGD:S000003898	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:CPLX3O-23_SULFITE-REDUCT-RXN_controller BFO:0000051 gomodel:SGD_S000003898_CPLX3O-23_component."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/27; endpoint types: /individuals/18/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-029_54421c98d23c	gomodel:SULFITE-REDUCT-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:SULFITE-REDUCT-RXN RO:0002233 gomodel:CHEBI_15378_SULFITE-REDUCT-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/28; endpoint types: /individuals/22/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-030_9a28e58a17fb	gomodel:SULFATE-ADENYLYLTRANS-RXN	RO:0002233	CHEBI:16189	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:SULFATE-ADENYLYLTRANS-RXN RO:0002233 gomodel:CHEBI_16189_SULFATE-ADENYLYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/29; endpoint types: /individuals/21/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-031_ef27c40cf008	gomodel:ADENYLYLSULFKIN-RXN	BFO:0000050	GO:0000103	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:ADENYLYLSULFKIN-RXN BFO:0000050 gomodel:YeastPathways_SO4ASSIM-PWY/YeastPathways_SO4ASSIM-PWY."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/30; endpoint types: /individuals/0/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-032_46bddceb5e34	gomodel:SULFATE-ADENYLYLTRANS-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:SULFATE-ADENYLYLTRANS-RXN RO:0002234 gomodel:CHEBI_29888_SULFATE-ADENYLYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/31; endpoint types: /individuals/21/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-033_3711c6a7b4f3	gomodel:ADENYLYLSULFKIN-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:ADENYLYLSULFKIN-RXN RO:0002234 gomodel:CHEBI_456216_ADENYLYLSULFKIN-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/32; endpoint types: /individuals/0/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-034_8e27f332e040	gomodel:1.8.4.8-RXN	RO:0002233	CHEBI:58339	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:1.8.4.8-RXN RO:0002233 gomodel:CHEBI_58339_ADENYLYLSULFKIN-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/33; endpoint types: /individuals/60/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-035_8eaa50699bf5	gomodel:ADENYLYLSULFKIN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:ADENYLYLSULFKIN-RXN RO:0002233 gomodel:CHEBI_30616_ADENYLYLSULFKIN-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/34; endpoint types: /individuals/0/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-036_56e506a3ff1a	gomodel:SULFATE-ADENYLYLTRANS-RXN	BFO:0000050	GO:0000103	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:SULFATE-ADENYLYLTRANS-RXN BFO:0000050 gomodel:YeastPathways_SO4ASSIM-PWY/YeastPathways_SO4ASSIM-PWY."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/35; endpoint types: /individuals/21/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-037_76990fc9cdbb	SGD:S000006371	pathwaymech:enables	gomodel:1.8.4.8-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:1.8.4.8-RXN RO:0002333 gomodel:YPR167C-MONOMER_1.8.4.8-RXN_controller."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/36; endpoint types: /individuals/60/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-038_50e4c05cdde2	gomodel:1.8.4.8-RXN	RO:0002413	gomodel:SULFITE-REDUCT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:1.8.4.8-RXN RO:0002413 gomodel:SULFITE-REDUCT-RXN."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/37; endpoint types: /individuals/60/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_edge-039_35be12c73577	gomodel:SULFITE-REDUCT-RXN	BFO:0000050	GO:0000103	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SO4ASSIM-PWY		"[{""reference_id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_assertion"": ""The model asserts gomodel:SULFITE-REDUCT-RXN BFO:0000050 gomodel:YeastPathways_SO4ASSIM-PWY/YeastPathways_SO4ASSIM-PWY."", ""source_locator"": ""./YeastPathways_SO4ASSIM-PWY.json#/facts/38; endpoint types: /individuals/22/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_SO4ASSIM-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_SO4ASSIM-PWY.json"", ""title"": ""SGD GO-CAM assimilatory sulfate reduction I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_complex-bad15bc0cd24_d0c17516a6b1	SGD:S000217821	BFO:0000051	CHEBI:64607	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217821	ECO:0005547: inferred by curator; source stoichiometry minValue: 2, maxValue: 2	"[{""reference_id"": ""SGD:S000217821"", ""source_assertion"": ""Complex Portal CPX-3163 lists CHEBI:64607 as a small molecule component; complex evidence is ECO:0005547: inferred by curator."", ""source_locator"": ""Complex Portal JSON #/participants/2; /evidenceType""}]"	"[{""id"": ""SGD:S000217821"", ""source_sha256"": ""0fcb89604504093cdb01bb1dbd77394bf0bd9c3488dfeedbabeb1434c49ed4e8"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-3163: Sulfite reductase complex (NADPH)"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-3163""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_complex-5707ce058ccc_718f52bbc619	SGD:S000217821	BFO:0000051	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217821	ECO:0005547: inferred by curator; source stoichiometry minValue: 2, maxValue: 2	"[{""reference_id"": ""SGD:S000217821"", ""source_assertion"": ""Complex Portal CPX-3163 lists CHEBI:57692 as a small molecule component; complex evidence is ECO:0005547: inferred by curator."", ""source_locator"": ""Complex Portal JSON #/participants/3; /evidenceType""}]"	"[{""id"": ""SGD:S000217821"", ""source_sha256"": ""0fcb89604504093cdb01bb1dbd77394bf0bd9c3488dfeedbabeb1434c49ed4e8"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-3163: Sulfite reductase complex (NADPH)"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-3163""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_complex-5ba5f370baee_3d83d0db5502	SGD:S000217821	BFO:0000051	CHEBI:58210	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217821	ECO:0005547: inferred by curator; source stoichiometry minValue: 2, maxValue: 2	"[{""reference_id"": ""SGD:S000217821"", ""source_assertion"": ""Complex Portal CPX-3163 lists CHEBI:58210 as a small molecule component; complex evidence is ECO:0005547: inferred by curator."", ""source_locator"": ""Complex Portal JSON #/participants/4; /evidenceType""}]"	"[{""id"": ""SGD:S000217821"", ""source_sha256"": ""0fcb89604504093cdb01bb1dbd77394bf0bd9c3488dfeedbabeb1434c49ed4e8"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-3163: Sulfite reductase complex (NADPH)"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-3163""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_complex-3f892f504f59_e4c2facbbe00	SGD:S000217821	BFO:0000051	CHEBI:28599	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217821	ECO:0005547: inferred by curator; source stoichiometry minValue: 2, maxValue: 2	"[{""reference_id"": ""SGD:S000217821"", ""source_assertion"": ""Complex Portal CPX-3163 lists CHEBI:28599 as a small molecule component; complex evidence is ECO:0005547: inferred by curator."", ""source_locator"": ""Complex Portal JSON #/participants/5; /evidenceType""}]"	"[{""id"": ""SGD:S000217821"", ""source_sha256"": ""0fcb89604504093cdb01bb1dbd77394bf0bd9c3488dfeedbabeb1434c49ed4e8"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-3163: Sulfite reductase complex (NADPH)"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-3163""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_complex-1fcc96fac5a7_2fa8f334de20	SGD:S000217821	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217821	Complex location from the independent composition source; original GO-CAM activity locations are retained with their own provenance.	"[{""reference_id"": ""SGD:S000217821"", ""source_assertion"": ""Complex Portal CPX-3163 records cellular location GO:0005737 (cytoplasm); its evidence classification is ECO:0005547: inferred by curator."", ""source_locator"": ""Complex Portal JSON #/crossReferences/1; /evidenceType""}]"	"[{""id"": ""SGD:S000217821"", ""source_sha256"": ""0fcb89604504093cdb01bb1dbd77394bf0bd9c3488dfeedbabeb1434c49ed4e8"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-3163: Sulfite reductase complex (NADPH)"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-3163""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_location-99241a05b311_3400b20efa8c	SGD:S000003771	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08536	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03106); ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P08536"", ""source_assertion"": ""UniProtKB:P08536 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/211/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P08536"", ""source_assertion"": ""UniProtKB:P08536 has the exact SGD cross-reference SGD:S000003771."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/211/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P08536"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P08536 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_location-5553ee0c946f_97630385cba0	SGD:S000003898	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47169	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P47169"", ""source_assertion"": ""UniProtKB:P47169 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1984/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P47169"", ""source_assertion"": ""UniProtKB:P47169 has the exact SGD cross-reference SGD:S000003898."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1984/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P47169"", ""source_sha256"": ""2ad9b6d84d565238960a053870fa90a6033bc212bbe1a4c9923fd55d7e7d7fc1"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47169 SGD cross-reference"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_cofactor-4193d639ed35_a55dc5b8883e	SGD:S000001926	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39692	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 FAD per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P39692"", ""source_assertion"": ""UniProtKB:P39692 annotates CHEBI:57692 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3677/comments/0/cofactors/0; /results/3677/comments/0/note""}, {""reference_id"": ""UniProtKB:P39692"", ""source_assertion"": ""UniProtKB:P39692 has the exact SGD cross-reference SGD:S000001926."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3677/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P39692"", ""source_sha256"": ""2ad9b6d84d565238960a053870fa90a6033bc212bbe1a4c9923fd55d7e7d7fc1"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39692 SGD cross-reference"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_cofactor-5c1742e090c6_f8fa5f331923	SGD:S000001926	pathwaymech:has_cofactor	CHEBI:58210	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39692	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 FMN per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P39692"", ""source_assertion"": ""UniProtKB:P39692 annotates CHEBI:58210 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3677/comments/1/cofactors/0; /results/3677/comments/1/note""}, {""reference_id"": ""UniProtKB:P39692"", ""source_assertion"": ""UniProtKB:P39692 has the exact SGD cross-reference SGD:S000001926."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3677/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P39692"", ""source_sha256"": ""2ad9b6d84d565238960a053870fa90a6033bc212bbe1a4c9923fd55d7e7d7fc1"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39692 SGD cross-reference"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_cofactor-9d46cfed5fbc_bd66f48ac82a	SGD:S000003898	pathwaymech:has_cofactor	CHEBI:60052	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47169	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 siroheme per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P47169"", ""source_assertion"": ""UniProtKB:P47169 annotates CHEBI:60052 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1984/comments/0/cofactors/0; /results/1984/comments/0/note""}, {""reference_id"": ""UniProtKB:P47169"", ""source_assertion"": ""UniProtKB:P47169 has the exact SGD cross-reference SGD:S000003898."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1984/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P47169"", ""source_sha256"": ""2ad9b6d84d565238960a053870fa90a6033bc212bbe1a4c9923fd55d7e7d7fc1"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47169 SGD cross-reference"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SO4ASSIM-PWY_cofactor-935db9962dc9_652ac79e5c09	SGD:S000003898	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47169	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 [4Fe-4S] cluster per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P47169"", ""source_assertion"": ""UniProtKB:P47169 annotates CHEBI:49883 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1984/comments/1/cofactors/0; /results/1984/comments/1/note""}, {""reference_id"": ""UniProtKB:P47169"", ""source_assertion"": ""UniProtKB:P47169 has the exact SGD cross-reference SGD:S000003898."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1984/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P47169"", ""source_sha256"": ""2ad9b6d84d565238960a053870fa90a6033bc212bbe1a4c9923fd55d7e7d7fc1"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47169 SGD cross-reference"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-001_21f5fee2dd5b	MetaCyc:ISOCHORSYN-RXN	RO:0002233	MetaCyc:CHORISMATE	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CHORISMATE|MetaCyc:ISOCHORSYN-RXN	Coefficient 1.	"[{""reference_id"": ""MetaCyc:ISOCHORSYN-RXN"", ""source_assertion"": ""The native left slot specifies CHORISMATE with coefficient 1. The source direction is REVERSIBLE; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""ISOCHORSYN-RXN\""]/left/*[@frameid=\""CHORISMATE\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:CHORISMATE"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""CHORISMATE\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:CHORISMATE"", ""source_sha256"": ""4811b8ec37df583759cf96c4b0c012102e01c5fc5d0aec178cb8fca0c3566649"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CHORISMATE"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CHORISMATE""}, {""id"": ""MetaCyc:ISOCHORSYN-RXN"", ""source_sha256"": ""12b0f7a51414fd2dc6ea14d9596d9cc7f0fcc121d0843c434e3ae5b23af90198"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native ISOCHORSYN-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ISOCHORSYN-RXN""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-002_998f07417f9c	MetaCyc:ISOCHORSYN-RXN	RO:0002234	MetaCyc:ISOCHORISMATE	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ISOCHORISMATE|MetaCyc:ISOCHORSYN-RXN	Coefficient 1.	"[{""reference_id"": ""MetaCyc:ISOCHORSYN-RXN"", ""source_assertion"": ""The native right slot specifies ISOCHORISMATE with coefficient 1. The source direction is REVERSIBLE; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""ISOCHORSYN-RXN\""]/right/*[@frameid=\""ISOCHORISMATE\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:ISOCHORISMATE"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""ISOCHORISMATE\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:ISOCHORISMATE"", ""source_sha256"": ""16e13f56ec3e4ad9f2cdd18af890e06954f8b654bf5634a070983cbb2e89ed66"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native ISOCHORISMATE"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ISOCHORISMATE""}, {""id"": ""MetaCyc:ISOCHORSYN-RXN"", ""source_sha256"": ""12b0f7a51414fd2dc6ea14d9596d9cc7f0fcc121d0843c434e3ae5b23af90198"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native ISOCHORSYN-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ISOCHORSYN-RXN""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-003_5872ba02f359	MetaCyc:ISOCHORMAT-RXN	RO:0002233	MetaCyc:WATER	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ISOCHORMAT-RXN|MetaCyc:WATER	Coefficient 1.	"[{""reference_id"": ""MetaCyc:ISOCHORMAT-RXN"", ""source_assertion"": ""The native left slot specifies WATER with coefficient 1. The source direction is LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""ISOCHORMAT-RXN\""]/left/*[@frameid=\""WATER\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:WATER"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""WATER\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:ISOCHORMAT-RXN"", ""source_sha256"": ""17750d21f912eb41d92fa0e73773cf03caa447c64bcf1467fda491f69175c76c"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native ISOCHORMAT-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ISOCHORMAT-RXN""}, {""id"": ""MetaCyc:WATER"", ""source_sha256"": ""47621552fb854daf04df0375c4540b0f42103652ec2d2a5f384ad06dead702e3"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native WATER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:WATER""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-004_88e28eddbb7a	MetaCyc:ISOCHORMAT-RXN	RO:0002233	MetaCyc:ISOCHORISMATE	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ISOCHORISMATE|MetaCyc:ISOCHORMAT-RXN	Coefficient 1.	"[{""reference_id"": ""MetaCyc:ISOCHORMAT-RXN"", ""source_assertion"": ""The native left slot specifies ISOCHORISMATE with coefficient 1. The source direction is LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""ISOCHORMAT-RXN\""]/left/*[@frameid=\""ISOCHORISMATE\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:ISOCHORISMATE"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""ISOCHORISMATE\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:ISOCHORISMATE"", ""source_sha256"": ""16e13f56ec3e4ad9f2cdd18af890e06954f8b654bf5634a070983cbb2e89ed66"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native ISOCHORISMATE"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ISOCHORISMATE""}, {""id"": ""MetaCyc:ISOCHORMAT-RXN"", ""source_sha256"": ""17750d21f912eb41d92fa0e73773cf03caa447c64bcf1467fda491f69175c76c"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native ISOCHORMAT-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ISOCHORMAT-RXN""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-005_956b80612175	MetaCyc:ISOCHORMAT-RXN	RO:0002234	MetaCyc:PYRUVATE	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ISOCHORMAT-RXN|MetaCyc:PYRUVATE	Coefficient 1.	"[{""reference_id"": ""MetaCyc:ISOCHORMAT-RXN"", ""source_assertion"": ""The native right slot specifies PYRUVATE with coefficient 1. The source direction is LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""ISOCHORMAT-RXN\""]/right/*[@frameid=\""PYRUVATE\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:PYRUVATE"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""PYRUVATE\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:ISOCHORMAT-RXN"", ""source_sha256"": ""17750d21f912eb41d92fa0e73773cf03caa447c64bcf1467fda491f69175c76c"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native ISOCHORMAT-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ISOCHORMAT-RXN""}, {""id"": ""MetaCyc:PYRUVATE"", ""source_sha256"": ""13b3ec730b89505a1af003bbe8610baef458b4fcb8f5f499db584bb75df56d07"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PYRUVATE"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PYRUVATE""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-006_94f7b28a4d6b	MetaCyc:ISOCHORMAT-RXN	RO:0002234	MetaCyc:DIHYDRO-DIOH-BENZOATE	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DIHYDRO-DIOH-BENZOATE|MetaCyc:ISOCHORMAT-RXN	Coefficient 1.	"[{""reference_id"": ""MetaCyc:ISOCHORMAT-RXN"", ""source_assertion"": ""The native right slot specifies DIHYDRO-DIOH-BENZOATE with coefficient 1. The source direction is LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""ISOCHORMAT-RXN\""]/right/*[@frameid=\""DIHYDRO-DIOH-BENZOATE\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:DIHYDRO-DIOH-BENZOATE"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""DIHYDRO-DIOH-BENZOATE\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:DIHYDRO-DIOH-BENZOATE"", ""source_sha256"": ""03f6d626eb404cf641bc86e6f79c3f59f1204f887225c60610c1f945f69dd18d"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DIHYDRO-DIOH-BENZOATE"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DIHYDRO-DIOH-BENZOATE""}, {""id"": ""MetaCyc:ISOCHORMAT-RXN"", ""source_sha256"": ""17750d21f912eb41d92fa0e73773cf03caa447c64bcf1467fda491f69175c76c"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native ISOCHORMAT-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ISOCHORMAT-RXN""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-007_596f51089086	MetaCyc:DHBDEHYD-RXN	RO:0002233	MetaCyc:DIHYDRO-DIOH-BENZOATE	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DHBDEHYD-RXN|MetaCyc:DIHYDRO-DIOH-BENZOATE	Coefficient 1.	"[{""reference_id"": ""MetaCyc:DHBDEHYD-RXN"", ""source_assertion"": ""The native left slot specifies DIHYDRO-DIOH-BENZOATE with coefficient 1. The source direction is LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""DHBDEHYD-RXN\""]/left/*[@frameid=\""DIHYDRO-DIOH-BENZOATE\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:DIHYDRO-DIOH-BENZOATE"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""DIHYDRO-DIOH-BENZOATE\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:DHBDEHYD-RXN"", ""source_sha256"": ""e694e624fe8f8d1690686a60f51bed77323eb276f5ccecf67ecc9860c83de4e0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DHBDEHYD-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHBDEHYD-RXN""}, {""id"": ""MetaCyc:DIHYDRO-DIOH-BENZOATE"", ""source_sha256"": ""03f6d626eb404cf641bc86e6f79c3f59f1204f887225c60610c1f945f69dd18d"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DIHYDRO-DIOH-BENZOATE"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DIHYDRO-DIOH-BENZOATE""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-008_e823568a4b09	MetaCyc:DHBDEHYD-RXN	RO:0002233	MetaCyc:NAD	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DHBDEHYD-RXN|MetaCyc:NAD	Coefficient 1.	"[{""reference_id"": ""MetaCyc:DHBDEHYD-RXN"", ""source_assertion"": ""The native left slot specifies NAD with coefficient 1. The source direction is LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""DHBDEHYD-RXN\""]/left/*[@frameid=\""NAD\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:NAD"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""NAD\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:DHBDEHYD-RXN"", ""source_sha256"": ""e694e624fe8f8d1690686a60f51bed77323eb276f5ccecf67ecc9860c83de4e0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DHBDEHYD-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHBDEHYD-RXN""}, {""id"": ""MetaCyc:NAD"", ""source_sha256"": ""5688bee1cb2ca3c5fffc8d353fdd09855140633d5cb925fea91552d5c6d57166"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native NAD"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:NAD""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-009_36d69c4cecd5	MetaCyc:DHBDEHYD-RXN	RO:0002234	MetaCyc:2-3-DIHYDROXYBENZOATE	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:2-3-DIHYDROXYBENZOATE|MetaCyc:DHBDEHYD-RXN	Coefficient 1.	"[{""reference_id"": ""MetaCyc:DHBDEHYD-RXN"", ""source_assertion"": ""The native right slot specifies 2-3-DIHYDROXYBENZOATE with coefficient 1. The source direction is LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""DHBDEHYD-RXN\""]/right/*[@frameid=\""2-3-DIHYDROXYBENZOATE\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:2-3-DIHYDROXYBENZOATE"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""2-3-DIHYDROXYBENZOATE\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:2-3-DIHYDROXYBENZOATE"", ""source_sha256"": ""659433ddef3d605108954e3ff59606092d165fdf250b09be011edb472dbab93d"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native 2-3-DIHYDROXYBENZOATE"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:2-3-DIHYDROXYBENZOATE""}, {""id"": ""MetaCyc:DHBDEHYD-RXN"", ""source_sha256"": ""e694e624fe8f8d1690686a60f51bed77323eb276f5ccecf67ecc9860c83de4e0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DHBDEHYD-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHBDEHYD-RXN""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-010_02e3c2643606	MetaCyc:DHBDEHYD-RXN	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:DHBDEHYD-RXN|MetaCyc:NADH	Coefficient 1.	"[{""reference_id"": ""MetaCyc:DHBDEHYD-RXN"", ""source_assertion"": ""The native right slot specifies NADH with coefficient 1. The source direction is LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""DHBDEHYD-RXN\""]/right/*[@frameid=\""NADH\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:NADH"", ""source_assertion"": ""The native CML and InChI define the ionic structure selected as CHEBI:57945; identity is checked independently against the complete ChEBI term, not its display name."", ""source_locator"": ""Compound[@frameid=\""NADH\""]/cml/molecule; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:57945 has the same complete InChI, elemental formula and charge as this native compound; the selected label is its canonical ChEBI label."", ""source_locator"": ""statements WHERE subject=\""CHEBI:57945\""; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge, rdfs:label""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers full original uncompressed Semantic SQL database"", ""title"": ""ChEBI ionic ATP, AMP and NADH identity authorities"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:DHBDEHYD-RXN"", ""source_sha256"": ""e694e624fe8f8d1690686a60f51bed77323eb276f5ccecf67ecc9860c83de4e0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DHBDEHYD-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHBDEHYD-RXN""}, {""id"": ""MetaCyc:NADH"", ""source_sha256"": ""77876c60fc62c91f55b0937bd053d79a27b6cc19e96c904fd414b0eded765ba6"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native NADH"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:NADH""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-011_e2c7edcebce2	MetaCyc:DHBDEHYD-RXN	RO:0002234	MetaCyc:PROTON	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DHBDEHYD-RXN|MetaCyc:PROTON	Coefficient 1.	"[{""reference_id"": ""MetaCyc:DHBDEHYD-RXN"", ""source_assertion"": ""The native right slot specifies PROTON with coefficient 1. The source direction is LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""DHBDEHYD-RXN\""]/right/*[@frameid=\""PROTON\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""PROTON\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:DHBDEHYD-RXN"", ""source_sha256"": ""e694e624fe8f8d1690686a60f51bed77323eb276f5ccecf67ecc9860c83de4e0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DHBDEHYD-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHBDEHYD-RXN""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PROTON"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-012_8bb19b3b8e52	MetaCyc:DHBAMPLIG-RXN	RO:0002233	MetaCyc:PROTON	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DHBAMPLIG-RXN|MetaCyc:PROTON	Coefficient 1.	"[{""reference_id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_assertion"": ""The native left slot specifies PROTON with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""DHBAMPLIG-RXN\""]/left/*[@frameid=\""PROTON\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""PROTON\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_sha256"": ""baf9b7ffbe51f1f2bf07f3717b39891fbece11f323b0ad68687b4c9dba0ae6e0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DHBAMPLIG-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHBAMPLIG-RXN""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PROTON"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-013_274b38387d02	MetaCyc:DHBAMPLIG-RXN	RO:0002233	MetaCyc:2-3-DIHYDROXYBENZOATE	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:2-3-DIHYDROXYBENZOATE|MetaCyc:DHBAMPLIG-RXN	Coefficient 1.	"[{""reference_id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_assertion"": ""The native left slot specifies 2-3-DIHYDROXYBENZOATE with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""DHBAMPLIG-RXN\""]/left/*[@frameid=\""2-3-DIHYDROXYBENZOATE\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:2-3-DIHYDROXYBENZOATE"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""2-3-DIHYDROXYBENZOATE\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:2-3-DIHYDROXYBENZOATE"", ""source_sha256"": ""659433ddef3d605108954e3ff59606092d165fdf250b09be011edb472dbab93d"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native 2-3-DIHYDROXYBENZOATE"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:2-3-DIHYDROXYBENZOATE""}, {""id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_sha256"": ""baf9b7ffbe51f1f2bf07f3717b39891fbece11f323b0ad68687b4c9dba0ae6e0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DHBAMPLIG-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHBAMPLIG-RXN""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-014_7060576ee2ac	MetaCyc:DHBAMPLIG-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:ATP|MetaCyc:DHBAMPLIG-RXN	Coefficient 1.	"[{""reference_id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_assertion"": ""The native left slot specifies ATP with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""DHBAMPLIG-RXN\""]/left/*[@frameid=\""ATP\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:ATP"", ""source_assertion"": ""The native CML and InChI define the ionic structure selected as CHEBI:30616; identity is checked independently against the complete ChEBI term, not its display name."", ""source_locator"": ""Compound[@frameid=\""ATP\""]/cml/molecule; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:30616 has the same complete InChI, elemental formula and charge as this native compound; the selected label is its canonical ChEBI label."", ""source_locator"": ""statements WHERE subject=\""CHEBI:30616\""; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge, rdfs:label""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers full original uncompressed Semantic SQL database"", ""title"": ""ChEBI ionic ATP, AMP and NADH identity authorities"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:ATP"", ""source_sha256"": ""bb03bc7d49a62af159cb0563a5b5a58e655787bb44290cf682b4a723a2d93f50"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native ATP"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ATP""}, {""id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_sha256"": ""baf9b7ffbe51f1f2bf07f3717b39891fbece11f323b0ad68687b4c9dba0ae6e0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DHBAMPLIG-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHBAMPLIG-RXN""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-015_c6102794ec36	MetaCyc:DHBAMPLIG-RXN	RO:0002234	MetaCyc:CPD-62	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-62|MetaCyc:DHBAMPLIG-RXN	Coefficient 1.	"[{""reference_id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_assertion"": ""The native right slot specifies CPD-62 with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""DHBAMPLIG-RXN\""]/right/*[@frameid=\""CPD-62\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-62"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""CPD-62\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:CPD-62"", ""source_sha256"": ""f9157decc86cac9b63db0043ab5215efbeae475105c608a63fec33b687aeaa71"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CPD-62"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-62""}, {""id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_sha256"": ""baf9b7ffbe51f1f2bf07f3717b39891fbece11f323b0ad68687b4c9dba0ae6e0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DHBAMPLIG-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHBAMPLIG-RXN""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-016_f357e8333be2	MetaCyc:DHBAMPLIG-RXN	RO:0002234	MetaCyc:PPI	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DHBAMPLIG-RXN|MetaCyc:PPI	Coefficient 1.	"[{""reference_id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_assertion"": ""The native right slot specifies PPI with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""DHBAMPLIG-RXN\""]/right/*[@frameid=\""PPI\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:PPI"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""PPI\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_sha256"": ""baf9b7ffbe51f1f2bf07f3717b39891fbece11f323b0ad68687b4c9dba0ae6e0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DHBAMPLIG-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHBAMPLIG-RXN""}, {""id"": ""MetaCyc:PPI"", ""source_sha256"": ""9e6257dbc2e18b5c475d4a546eef842e55dd1432dbdada4d0a88d22c381aede9"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PPI"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PPI""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-017_c46f918e60db	MetaCyc:RXN-19449	RO:0002233	MetaCyc:CPD-62	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-62|MetaCyc:RXN-19449	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-19449"", ""source_assertion"": ""The native left slot specifies CPD-62 with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19449\""]/left/*[@frameid=\""CPD-62\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-62"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""CPD-62\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:CPD-62"", ""source_sha256"": ""f9157decc86cac9b63db0043ab5215efbeae475105c608a63fec33b687aeaa71"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CPD-62"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-62""}, {""id"": ""MetaCyc:RXN-19449"", ""source_sha256"": ""b7bc71f61ecb21cbfb23ad1d77ab11efd5d82e8e48b6b16304ee9a6cae7f1706"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19449"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19449""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-018_2548844ffb74	MetaCyc:RXN-19449	RO:0002233	MetaCyc:Holo-DhbB	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Holo-DhbB|MetaCyc:RXN-19449	Coefficient 1. Native carrier-state class, not an exact full polypeptide. DhbF contains two CP sites; state coefficients do not count whole NRPS molecules.	"[{""reference_id"": ""MetaCyc:RXN-19449"", ""source_assertion"": ""The native left slot specifies Holo-DhbB with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19449\""]/left/*[@frameid=\""Holo-DhbB\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:Holo-DhbB"", ""source_assertion"": ""This native protein class names the specified covalent carrier state. It does not identify a KH3-4 sequence or establish whole-enzyme stoichiometry."", ""source_locator"": ""Protein[@frameid=\""Holo-DhbB\""]/common-name; parent""}]"	"[{""id"": ""MetaCyc:Holo-DhbB"", ""source_sha256"": ""10b44a70171a20f03c78f040587ef4466eb8efcc4fe10e0b1131646ba934e6e7"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native Holo-DhbB"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Holo-DhbB""}, {""id"": ""MetaCyc:RXN-19449"", ""source_sha256"": ""b7bc71f61ecb21cbfb23ad1d77ab11efd5d82e8e48b6b16304ee9a6cae7f1706"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19449"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19449""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-019_4497f11449d2	MetaCyc:RXN-19449	RO:0002234	MetaCyc:23-dihydroxybenzoyl-DhbB	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:23-dihydroxybenzoyl-DhbB|MetaCyc:RXN-19449	Coefficient 1. Native carrier-state class, not an exact full polypeptide. DhbF contains two CP sites; state coefficients do not count whole NRPS molecules.	"[{""reference_id"": ""MetaCyc:RXN-19449"", ""source_assertion"": ""The native right slot specifies 23-dihydroxybenzoyl-DhbB with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19449\""]/right/*[@frameid=\""23-dihydroxybenzoyl-DhbB\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:23-dihydroxybenzoyl-DhbB"", ""source_assertion"": ""This native protein class names the specified covalent carrier state. It does not identify a KH3-4 sequence or establish whole-enzyme stoichiometry."", ""source_locator"": ""Protein[@frameid=\""23-dihydroxybenzoyl-DhbB\""]/common-name; parent; unmodified-form""}]"	"[{""id"": ""MetaCyc:23-dihydroxybenzoyl-DhbB"", ""source_sha256"": ""bc326f8df5cf5e1bc552c6d678a5eddd5291041f6b349b088a3b31f0a3466e21"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native 23-dihydroxybenzoyl-DhbB"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:23-dihydroxybenzoyl-DhbB""}, {""id"": ""MetaCyc:RXN-19449"", ""source_sha256"": ""b7bc71f61ecb21cbfb23ad1d77ab11efd5d82e8e48b6b16304ee9a6cae7f1706"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19449"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19449""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-020_f6dc98022d03	MetaCyc:RXN-19449	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:AMP|MetaCyc:RXN-19449	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-19449"", ""source_assertion"": ""The native right slot specifies AMP with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19449\""]/right/*[@frameid=\""AMP\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:AMP"", ""source_assertion"": ""The native CML and InChI define the ionic structure selected as CHEBI:456215; identity is checked independently against the complete ChEBI term, not its display name."", ""source_locator"": ""Compound[@frameid=\""AMP\""]/cml/molecule; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:456215 has the same complete InChI, elemental formula and charge as this native compound; the selected label is its canonical ChEBI label."", ""source_locator"": ""statements WHERE subject=\""CHEBI:456215\""; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge, rdfs:label""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers full original uncompressed Semantic SQL database"", ""title"": ""ChEBI ionic ATP, AMP and NADH identity authorities"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:AMP"", ""source_sha256"": ""f4de874fe3fd147827332ac5f9544e83b533d99e1141ba599a73ac9853f65a62"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native AMP"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:AMP""}, {""id"": ""MetaCyc:RXN-19449"", ""source_sha256"": ""b7bc71f61ecb21cbfb23ad1d77ab11efd5d82e8e48b6b16304ee9a6cae7f1706"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19449"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19449""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-021_3605ae924760	MetaCyc:RXN-19449	RO:0002234	MetaCyc:PROTON	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PROTON|MetaCyc:RXN-19449	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-19449"", ""source_assertion"": ""The native right slot specifies PROTON with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19449\""]/right/*[@frameid=\""PROTON\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""PROTON\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PROTON"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}, {""id"": ""MetaCyc:RXN-19449"", ""source_sha256"": ""b7bc71f61ecb21cbfb23ad1d77ab11efd5d82e8e48b6b16304ee9a6cae7f1706"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19449"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19449""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-022_2900213b735a	MetaCyc:RXN-9376	RO:0002233	MetaCyc:GLY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLY|MetaCyc:RXN-9376	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-9376"", ""source_assertion"": ""The native left slot specifies GLY with coefficient 1. The source direction is LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-9376\""]/left/*[@frameid=\""GLY\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:GLY"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""GLY\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:GLY"", ""source_sha256"": ""08998428c4ca65985610e955f134f8d13fe1aa2b1c5b6a26a960ff2a09f40ae0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native GLY"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GLY""}, {""id"": ""MetaCyc:RXN-9376"", ""source_sha256"": ""ab65ede5c40dc212695a9679d98f6834490ddc565be8bc1e0b6ff43906e49791"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-9376"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9376""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-023_60ccadfad180	MetaCyc:RXN-9376	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:ATP|MetaCyc:RXN-9376	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-9376"", ""source_assertion"": ""The native left slot specifies ATP with coefficient 1. The source direction is LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-9376\""]/left/*[@frameid=\""ATP\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:ATP"", ""source_assertion"": ""The native CML and InChI define the ionic structure selected as CHEBI:30616; identity is checked independently against the complete ChEBI term, not its display name."", ""source_locator"": ""Compound[@frameid=\""ATP\""]/cml/molecule; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:30616 has the same complete InChI, elemental formula and charge as this native compound; the selected label is its canonical ChEBI label."", ""source_locator"": ""statements WHERE subject=\""CHEBI:30616\""; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge, rdfs:label""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers full original uncompressed Semantic SQL database"", ""title"": ""ChEBI ionic ATP, AMP and NADH identity authorities"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:ATP"", ""source_sha256"": ""bb03bc7d49a62af159cb0563a5b5a58e655787bb44290cf682b4a723a2d93f50"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native ATP"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ATP""}, {""id"": ""MetaCyc:RXN-9376"", ""source_sha256"": ""ab65ede5c40dc212695a9679d98f6834490ddc565be8bc1e0b6ff43906e49791"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-9376"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9376""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-024_bd3091aff2d9	MetaCyc:RXN-9376	RO:0002234	MetaCyc:CPD-9993	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-9993|MetaCyc:RXN-9376	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-9376"", ""source_assertion"": ""The native right slot specifies CPD-9993 with coefficient 1. The source direction is LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-9376\""]/right/*[@frameid=\""CPD-9993\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-9993"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""CPD-9993\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:CPD-9993"", ""source_sha256"": ""d1967dcf9882896f037e772c9993bcea0ec88748967450c4724aba151fd24d2b"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CPD-9993"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-9993""}, {""id"": ""MetaCyc:RXN-9376"", ""source_sha256"": ""ab65ede5c40dc212695a9679d98f6834490ddc565be8bc1e0b6ff43906e49791"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-9376"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9376""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-025_06e17b64c08f	MetaCyc:RXN-9376	RO:0002234	MetaCyc:PPI	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PPI|MetaCyc:RXN-9376	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-9376"", ""source_assertion"": ""The native right slot specifies PPI with coefficient 1. The source direction is LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-9376\""]/right/*[@frameid=\""PPI\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:PPI"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""PPI\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:PPI"", ""source_sha256"": ""9e6257dbc2e18b5c475d4a546eef842e55dd1432dbdada4d0a88d22c381aede9"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PPI"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PPI""}, {""id"": ""MetaCyc:RXN-9376"", ""source_sha256"": ""ab65ede5c40dc212695a9679d98f6834490ddc565be8bc1e0b6ff43906e49791"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-9376"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9376""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-026_fb092b507a5c	MetaCyc:RXN-19458	RO:0002233	MetaCyc:CPD-9993	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-9993|MetaCyc:RXN-19458	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-19458"", ""source_assertion"": ""The native left slot specifies CPD-9993 with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19458\""]/left/*[@frameid=\""CPD-9993\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-9993"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""CPD-9993\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:CPD-9993"", ""source_sha256"": ""d1967dcf9882896f037e772c9993bcea0ec88748967450c4724aba151fd24d2b"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CPD-9993"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-9993""}, {""id"": ""MetaCyc:RXN-19458"", ""source_sha256"": ""ca9d5ecd07429de09a00e16885b4d009f995b8d7ae46b2edbf92475c52af9c63"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19458"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19458""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-027_cf3ce9e333c9	MetaCyc:RXN-19458	RO:0002233	MetaCyc:DhbF	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DhbF|MetaCyc:RXN-19458	Coefficient 1. Native carrier-state class, not an exact full polypeptide. DhbF contains two CP sites; state coefficients do not count whole NRPS molecules.	"[{""reference_id"": ""MetaCyc:RXN-19458"", ""source_assertion"": ""The native left slot specifies DhbF with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19458\""]/left/*[@frameid=\""DhbF\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:DhbF"", ""source_assertion"": ""This native protein class names the specified covalent carrier state. It does not identify a KH3-4 sequence or establish whole-enzyme stoichiometry."", ""source_locator"": ""Protein[@frameid=\""DhbF\""]/common-name; parent""}]"	"[{""id"": ""MetaCyc:DhbF"", ""source_sha256"": ""e6d402775acc49fc63f147f6a4619631cdc85e1aeb2657cf93305961f30e6c0d"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DhbF"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DhbF""}, {""id"": ""MetaCyc:RXN-19458"", ""source_sha256"": ""ca9d5ecd07429de09a00e16885b4d009f995b8d7ae46b2edbf92475c52af9c63"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19458"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19458""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-028_d087fd78017b	MetaCyc:RXN-19458	RO:0002234	MetaCyc:Glycyl-DhbF	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Glycyl-DhbF|MetaCyc:RXN-19458	Coefficient 1. Native carrier-state class, not an exact full polypeptide. DhbF contains two CP sites; state coefficients do not count whole NRPS molecules.	"[{""reference_id"": ""MetaCyc:RXN-19458"", ""source_assertion"": ""The native right slot specifies Glycyl-DhbF with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19458\""]/right/*[@frameid=\""Glycyl-DhbF\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:Glycyl-DhbF"", ""source_assertion"": ""This native protein class names the specified covalent carrier state. It does not identify a KH3-4 sequence or establish whole-enzyme stoichiometry."", ""source_locator"": ""Protein[@frameid=\""Glycyl-DhbF\""]/common-name; parent; unmodified-form""}]"	"[{""id"": ""MetaCyc:Glycyl-DhbF"", ""source_sha256"": ""03372c278dfc34d9acddd839b7f001cb6fdc92ebf3832c0c8ef590f6314e04f0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native Glycyl-DhbF"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Glycyl-DhbF""}, {""id"": ""MetaCyc:RXN-19458"", ""source_sha256"": ""ca9d5ecd07429de09a00e16885b4d009f995b8d7ae46b2edbf92475c52af9c63"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19458"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19458""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-029_94800ca42f01	MetaCyc:RXN-19458	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:AMP|MetaCyc:RXN-19458	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-19458"", ""source_assertion"": ""The native right slot specifies AMP with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19458\""]/right/*[@frameid=\""AMP\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:AMP"", ""source_assertion"": ""The native CML and InChI define the ionic structure selected as CHEBI:456215; identity is checked independently against the complete ChEBI term, not its display name."", ""source_locator"": ""Compound[@frameid=\""AMP\""]/cml/molecule; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:456215 has the same complete InChI, elemental formula and charge as this native compound; the selected label is its canonical ChEBI label."", ""source_locator"": ""statements WHERE subject=\""CHEBI:456215\""; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge, rdfs:label""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers full original uncompressed Semantic SQL database"", ""title"": ""ChEBI ionic ATP, AMP and NADH identity authorities"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:AMP"", ""source_sha256"": ""f4de874fe3fd147827332ac5f9544e83b533d99e1141ba599a73ac9853f65a62"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native AMP"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:AMP""}, {""id"": ""MetaCyc:RXN-19458"", ""source_sha256"": ""ca9d5ecd07429de09a00e16885b4d009f995b8d7ae46b2edbf92475c52af9c63"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19458"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19458""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-030_d71a84e68f31	MetaCyc:RXN-19460	RO:0002233	MetaCyc:23-dihydroxybenzoyl-DhbB	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:23-dihydroxybenzoyl-DhbB|MetaCyc:RXN-19460	Coefficient 1. Native carrier-state class, not an exact full polypeptide. DhbF contains two CP sites; state coefficients do not count whole NRPS molecules.	"[{""reference_id"": ""MetaCyc:RXN-19460"", ""source_assertion"": ""The native left slot specifies 23-dihydroxybenzoyl-DhbB with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19460\""]/left/*[@frameid=\""23-dihydroxybenzoyl-DhbB\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:23-dihydroxybenzoyl-DhbB"", ""source_assertion"": ""This native protein class names the specified covalent carrier state. It does not identify a KH3-4 sequence or establish whole-enzyme stoichiometry."", ""source_locator"": ""Protein[@frameid=\""23-dihydroxybenzoyl-DhbB\""]/common-name; parent; unmodified-form""}]"	"[{""id"": ""MetaCyc:23-dihydroxybenzoyl-DhbB"", ""source_sha256"": ""bc326f8df5cf5e1bc552c6d678a5eddd5291041f6b349b088a3b31f0a3466e21"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native 23-dihydroxybenzoyl-DhbB"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:23-dihydroxybenzoyl-DhbB""}, {""id"": ""MetaCyc:RXN-19460"", ""source_sha256"": ""d776387c9ec242d9cfe26c8dd6b36b58d61aaf4e6e7cadf21bfe2084edee5424"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19460"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19460""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-031_82f160b40400	MetaCyc:RXN-19460	RO:0002233	MetaCyc:Glycyl-DhbF	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Glycyl-DhbF|MetaCyc:RXN-19460	Coefficient 1. Native carrier-state class, not an exact full polypeptide. DhbF contains two CP sites; state coefficients do not count whole NRPS molecules.	"[{""reference_id"": ""MetaCyc:RXN-19460"", ""source_assertion"": ""The native left slot specifies Glycyl-DhbF with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19460\""]/left/*[@frameid=\""Glycyl-DhbF\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:Glycyl-DhbF"", ""source_assertion"": ""This native protein class names the specified covalent carrier state. It does not identify a KH3-4 sequence or establish whole-enzyme stoichiometry."", ""source_locator"": ""Protein[@frameid=\""Glycyl-DhbF\""]/common-name; parent; unmodified-form""}]"	"[{""id"": ""MetaCyc:Glycyl-DhbF"", ""source_sha256"": ""03372c278dfc34d9acddd839b7f001cb6fdc92ebf3832c0c8ef590f6314e04f0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native Glycyl-DhbF"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Glycyl-DhbF""}, {""id"": ""MetaCyc:RXN-19460"", ""source_sha256"": ""d776387c9ec242d9cfe26c8dd6b36b58d61aaf4e6e7cadf21bfe2084edee5424"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19460"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19460""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-032_d38948376311	MetaCyc:RXN-19460	RO:0002234	MetaCyc:DHB-glycyl-DhbF	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DHB-glycyl-DhbF|MetaCyc:RXN-19460	Coefficient 1. Native carrier-state class, not an exact full polypeptide. DhbF contains two CP sites; state coefficients do not count whole NRPS molecules.	"[{""reference_id"": ""MetaCyc:RXN-19460"", ""source_assertion"": ""The native right slot specifies DHB-glycyl-DhbF with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19460\""]/right/*[@frameid=\""DHB-glycyl-DhbF\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:DHB-glycyl-DhbF"", ""source_assertion"": ""This native protein class names the specified covalent carrier state. It does not identify a KH3-4 sequence or establish whole-enzyme stoichiometry."", ""source_locator"": ""Protein[@frameid=\""DHB-glycyl-DhbF\""]/common-name; parent; unmodified-form""}]"	"[{""id"": ""MetaCyc:DHB-glycyl-DhbF"", ""source_sha256"": ""58685ce1fac517e5bfdb470a4e76f0159c18369f78c48d010771bd0e7276907c"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DHB-glycyl-DhbF"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHB-glycyl-DhbF""}, {""id"": ""MetaCyc:RXN-19460"", ""source_sha256"": ""d776387c9ec242d9cfe26c8dd6b36b58d61aaf4e6e7cadf21bfe2084edee5424"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19460"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19460""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-033_64c8ce3830c2	MetaCyc:RXN-19460	RO:0002234	MetaCyc:Holo-DhbB	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Holo-DhbB|MetaCyc:RXN-19460	Coefficient 1. Native carrier-state class, not an exact full polypeptide. DhbF contains two CP sites; state coefficients do not count whole NRPS molecules.	"[{""reference_id"": ""MetaCyc:RXN-19460"", ""source_assertion"": ""The native right slot specifies Holo-DhbB with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19460\""]/right/*[@frameid=\""Holo-DhbB\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:Holo-DhbB"", ""source_assertion"": ""This native protein class names the specified covalent carrier state. It does not identify a KH3-4 sequence or establish whole-enzyme stoichiometry."", ""source_locator"": ""Protein[@frameid=\""Holo-DhbB\""]/common-name; parent""}]"	"[{""id"": ""MetaCyc:Holo-DhbB"", ""source_sha256"": ""10b44a70171a20f03c78f040587ef4466eb8efcc4fe10e0b1131646ba934e6e7"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native Holo-DhbB"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Holo-DhbB""}, {""id"": ""MetaCyc:RXN-19460"", ""source_sha256"": ""d776387c9ec242d9cfe26c8dd6b36b58d61aaf4e6e7cadf21bfe2084edee5424"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19460"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19460""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-034_4c1e15bdb0fe	MetaCyc:RXN-19460	RO:0002234	MetaCyc:PROTON	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PROTON|MetaCyc:RXN-19460	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-19460"", ""source_assertion"": ""The native right slot specifies PROTON with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19460\""]/right/*[@frameid=\""PROTON\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""PROTON\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PROTON"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}, {""id"": ""MetaCyc:RXN-19460"", ""source_sha256"": ""d776387c9ec242d9cfe26c8dd6b36b58d61aaf4e6e7cadf21bfe2084edee5424"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19460"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19460""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-035_f40cfac06749	MetaCyc:RXN-9377	RO:0002233	MetaCyc:THR	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-9377|MetaCyc:THR	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-9377"", ""source_assertion"": ""The native left slot specifies THR with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-9377\""]/left/*[@frameid=\""THR\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:THR"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""THR\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:RXN-9377"", ""source_sha256"": ""12815cb9af8013f0e6176f07cf63617b0ffd07166249d6997ea0bd3a10151f27"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-9377"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9377""}, {""id"": ""MetaCyc:THR"", ""source_sha256"": ""2b868b5d71d340dc8b44c3ff9e4712414404e7236526d459ea4abe0c4af678bb"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native THR"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:THR""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-036_642215b53c8b	MetaCyc:RXN-9377	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:ATP|MetaCyc:RXN-9377	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-9377"", ""source_assertion"": ""The native left slot specifies ATP with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-9377\""]/left/*[@frameid=\""ATP\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:ATP"", ""source_assertion"": ""The native CML and InChI define the ionic structure selected as CHEBI:30616; identity is checked independently against the complete ChEBI term, not its display name."", ""source_locator"": ""Compound[@frameid=\""ATP\""]/cml/molecule; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:30616 has the same complete InChI, elemental formula and charge as this native compound; the selected label is its canonical ChEBI label."", ""source_locator"": ""statements WHERE subject=\""CHEBI:30616\""; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge, rdfs:label""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers full original uncompressed Semantic SQL database"", ""title"": ""ChEBI ionic ATP, AMP and NADH identity authorities"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:ATP"", ""source_sha256"": ""bb03bc7d49a62af159cb0563a5b5a58e655787bb44290cf682b4a723a2d93f50"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native ATP"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ATP""}, {""id"": ""MetaCyc:RXN-9377"", ""source_sha256"": ""12815cb9af8013f0e6176f07cf63617b0ffd07166249d6997ea0bd3a10151f27"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-9377"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9377""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-037_f430ee2c023f	MetaCyc:RXN-9377	RO:0002233	MetaCyc:PROTON	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PROTON|MetaCyc:RXN-9377	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-9377"", ""source_assertion"": ""The native left slot specifies PROTON with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-9377\""]/left/*[@frameid=\""PROTON\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""PROTON\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PROTON"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}, {""id"": ""MetaCyc:RXN-9377"", ""source_sha256"": ""12815cb9af8013f0e6176f07cf63617b0ffd07166249d6997ea0bd3a10151f27"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-9377"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9377""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-038_8abfc99bbc19	MetaCyc:RXN-9377	RO:0002234	MetaCyc:CPD-9994	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-9994|MetaCyc:RXN-9377	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-9377"", ""source_assertion"": ""The native right slot specifies CPD-9994 with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-9377\""]/right/*[@frameid=\""CPD-9994\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-9994"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""CPD-9994\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:CPD-9994"", ""source_sha256"": ""4706cab6037b870b8841b256d8ddcb607a65d35648b7cd5e4a5aba078886cb52"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CPD-9994"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-9994""}, {""id"": ""MetaCyc:RXN-9377"", ""source_sha256"": ""12815cb9af8013f0e6176f07cf63617b0ffd07166249d6997ea0bd3a10151f27"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-9377"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9377""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-039_b40b943d661d	MetaCyc:RXN-9377	RO:0002234	MetaCyc:PPI	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PPI|MetaCyc:RXN-9377	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-9377"", ""source_assertion"": ""The native right slot specifies PPI with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-9377\""]/right/*[@frameid=\""PPI\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:PPI"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""PPI\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:PPI"", ""source_sha256"": ""9e6257dbc2e18b5c475d4a546eef842e55dd1432dbdada4d0a88d22c381aede9"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PPI"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PPI""}, {""id"": ""MetaCyc:RXN-9377"", ""source_sha256"": ""12815cb9af8013f0e6176f07cf63617b0ffd07166249d6997ea0bd3a10151f27"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-9377"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9377""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-040_7b1d8f45014f	MetaCyc:RXN-19452	RO:0002233	MetaCyc:CPD-9994	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-9994|MetaCyc:RXN-19452	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-19452"", ""source_assertion"": ""The native left slot specifies CPD-9994 with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19452\""]/left/*[@frameid=\""CPD-9994\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-9994"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""CPD-9994\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:CPD-9994"", ""source_sha256"": ""4706cab6037b870b8841b256d8ddcb607a65d35648b7cd5e4a5aba078886cb52"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CPD-9994"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-9994""}, {""id"": ""MetaCyc:RXN-19452"", ""source_sha256"": ""d2d9608e4dbf6136419a93b14bb3946b44a9718afc6f6415cbe0ac5dd5bb237d"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19452"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19452""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-041_4193a9b489ba	MetaCyc:RXN-19452	RO:0002233	MetaCyc:DhbF	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DhbF|MetaCyc:RXN-19452	Coefficient 1. Native carrier-state class, not an exact full polypeptide. DhbF contains two CP sites; state coefficients do not count whole NRPS molecules.	"[{""reference_id"": ""MetaCyc:RXN-19452"", ""source_assertion"": ""The native left slot specifies DhbF with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19452\""]/left/*[@frameid=\""DhbF\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:DhbF"", ""source_assertion"": ""This native protein class names the specified covalent carrier state. It does not identify a KH3-4 sequence or establish whole-enzyme stoichiometry."", ""source_locator"": ""Protein[@frameid=\""DhbF\""]/common-name; parent""}]"	"[{""id"": ""MetaCyc:DhbF"", ""source_sha256"": ""e6d402775acc49fc63f147f6a4619631cdc85e1aeb2657cf93305961f30e6c0d"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DhbF"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DhbF""}, {""id"": ""MetaCyc:RXN-19452"", ""source_sha256"": ""d2d9608e4dbf6136419a93b14bb3946b44a9718afc6f6415cbe0ac5dd5bb237d"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19452"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19452""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-042_cb5432a4c7b0	MetaCyc:RXN-19452	RO:0002234	MetaCyc:Threonyl-DhbF	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-19452|MetaCyc:Threonyl-DhbF	Coefficient 1. Native carrier-state class, not an exact full polypeptide. DhbF contains two CP sites; state coefficients do not count whole NRPS molecules.	"[{""reference_id"": ""MetaCyc:RXN-19452"", ""source_assertion"": ""The native right slot specifies Threonyl-DhbF with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19452\""]/right/*[@frameid=\""Threonyl-DhbF\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:Threonyl-DhbF"", ""source_assertion"": ""This native protein class names the specified covalent carrier state. It does not identify a KH3-4 sequence or establish whole-enzyme stoichiometry."", ""source_locator"": ""Protein[@frameid=\""Threonyl-DhbF\""]/common-name; parent; unmodified-form""}]"	"[{""id"": ""MetaCyc:RXN-19452"", ""source_sha256"": ""d2d9608e4dbf6136419a93b14bb3946b44a9718afc6f6415cbe0ac5dd5bb237d"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19452"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19452""}, {""id"": ""MetaCyc:Threonyl-DhbF"", ""source_sha256"": ""5f71f7320299e353b5a0da9e673d3b6671b5b1ec97381284ad71e0a0fed790e0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native Threonyl-DhbF"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Threonyl-DhbF""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-043_70c816a99768	MetaCyc:RXN-19452	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:AMP|MetaCyc:RXN-19452	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-19452"", ""source_assertion"": ""The native right slot specifies AMP with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19452\""]/right/*[@frameid=\""AMP\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:AMP"", ""source_assertion"": ""The native CML and InChI define the ionic structure selected as CHEBI:456215; identity is checked independently against the complete ChEBI term, not its display name."", ""source_locator"": ""Compound[@frameid=\""AMP\""]/cml/molecule; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:456215 has the same complete InChI, elemental formula and charge as this native compound; the selected label is its canonical ChEBI label."", ""source_locator"": ""statements WHERE subject=\""CHEBI:456215\""; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge, rdfs:label""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers full original uncompressed Semantic SQL database"", ""title"": ""ChEBI ionic ATP, AMP and NADH identity authorities"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:AMP"", ""source_sha256"": ""f4de874fe3fd147827332ac5f9544e83b533d99e1141ba599a73ac9853f65a62"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native AMP"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:AMP""}, {""id"": ""MetaCyc:RXN-19452"", ""source_sha256"": ""d2d9608e4dbf6136419a93b14bb3946b44a9718afc6f6415cbe0ac5dd5bb237d"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19452"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19452""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-044_8bfc822617a5	MetaCyc:RXN-19452	RO:0002234	MetaCyc:PROTON	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PROTON|MetaCyc:RXN-19452	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-19452"", ""source_assertion"": ""The native right slot specifies PROTON with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19452\""]/right/*[@frameid=\""PROTON\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""PROTON\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PROTON"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}, {""id"": ""MetaCyc:RXN-19452"", ""source_sha256"": ""d2d9608e4dbf6136419a93b14bb3946b44a9718afc6f6415cbe0ac5dd5bb237d"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19452"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19452""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-045_814e47db681d	MetaCyc:RXN-19461	RO:0002233	MetaCyc:DHB-glycyl-DhbF	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DHB-glycyl-DhbF|MetaCyc:RXN-19461	Coefficient 1. Native carrier-state class, not an exact full polypeptide. DhbF contains two CP sites; state coefficients do not count whole NRPS molecules.	"[{""reference_id"": ""MetaCyc:RXN-19461"", ""source_assertion"": ""The native left slot specifies DHB-glycyl-DhbF with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19461\""]/left/*[@frameid=\""DHB-glycyl-DhbF\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:DHB-glycyl-DhbF"", ""source_assertion"": ""This native protein class names the specified covalent carrier state. It does not identify a KH3-4 sequence or establish whole-enzyme stoichiometry."", ""source_locator"": ""Protein[@frameid=\""DHB-glycyl-DhbF\""]/common-name; parent; unmodified-form""}]"	"[{""id"": ""MetaCyc:DHB-glycyl-DhbF"", ""source_sha256"": ""58685ce1fac517e5bfdb470a4e76f0159c18369f78c48d010771bd0e7276907c"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DHB-glycyl-DhbF"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHB-glycyl-DhbF""}, {""id"": ""MetaCyc:RXN-19461"", ""source_sha256"": ""909fd360958be5f9e9b590db37d24b0812a2ac127bf2f1c130573c0da3a67ae7"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19461"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19461""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-046_0ff3201e9d29	MetaCyc:RXN-19461	RO:0002233	MetaCyc:Threonyl-DhbF	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-19461|MetaCyc:Threonyl-DhbF	Coefficient 1. Native carrier-state class, not an exact full polypeptide. DhbF contains two CP sites; state coefficients do not count whole NRPS molecules.	"[{""reference_id"": ""MetaCyc:RXN-19461"", ""source_assertion"": ""The native left slot specifies Threonyl-DhbF with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19461\""]/left/*[@frameid=\""Threonyl-DhbF\""]; left/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:Threonyl-DhbF"", ""source_assertion"": ""This native protein class names the specified covalent carrier state. It does not identify a KH3-4 sequence or establish whole-enzyme stoichiometry."", ""source_locator"": ""Protein[@frameid=\""Threonyl-DhbF\""]/common-name; parent; unmodified-form""}]"	"[{""id"": ""MetaCyc:RXN-19461"", ""source_sha256"": ""909fd360958be5f9e9b590db37d24b0812a2ac127bf2f1c130573c0da3a67ae7"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19461"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19461""}, {""id"": ""MetaCyc:Threonyl-DhbF"", ""source_sha256"": ""5f71f7320299e353b5a0da9e673d3b6671b5b1ec97381284ad71e0a0fed790e0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native Threonyl-DhbF"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Threonyl-DhbF""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-047_68150f7ce6a0	MetaCyc:RXN-19461	RO:0002234	metanetx.chemical:MNXM743865	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-19461|PMID:39870587|metanetx.chemical:MNXM743865	Coefficient 1. Primary-supported threonyl reactive-state correction under the native transformation identity. The native arginyl frame and imported MNX sameAs are not accepted as exact equivalents. Coefficients count formal carrier states, not whole DhbF polypeptides.	"[{""reference_id"": ""MetaCyc:RXN-19461"", ""source_assertion"": ""The original right slot has coefficient 1 for DHB-glycyl-arginyl-DhbF. That arginyl name conflicts with the threonyl precursor and primary structure; this edge is a curated threonyl correction, not native-equation equivalence."", ""source_locator"": ""Reaction[@frameid=\""RXN-19461\""]/right/Protein; right/coefficient""}, {""reference_id"": ""metanetx.chemical:MNXM743865"", ""source_assertion"": ""The independently issued canonical name is the DHB-glycyl-L-threonyl DhbF state; native SMILES encodes a 2S,3R threonyl thioester and protein-continuation wildcards. It is a reactive class, not an exact full protein or a sameAs claim to the old arginyl frame."", ""source_locator"": ""Unique MolecularEntity JSON-LD: identifier, name, smiles; visible Properties: global charge -1""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""Figure 1b depicts DHB-Gly-L-Thr bound to the second DhbF CP and its trimeric cyclorelease. Figure 5 supports L-Thr selection; Figure 6 detects reconstituted bacillibactin."", ""source_locator"": ""PDF p.4 Figure 1b; p.8 Figure 5; pp.8-9 Figure 6""}]"	"[{""id"": ""MetaCyc:RXN-19461"", ""source_sha256"": ""909fd360958be5f9e9b590db37d24b0812a2ac127bf2f1c130573c0da3a67ae7"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19461"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19461""}, {""id"": ""PMID:39870587"", ""source_sha256"": ""b0634407933acfa5a161698520e4eb370a73955908b4af913f5c9cae877af86b"", ""source_version"": ""2025 Osaka official accepted manuscript and complete supplement, 30 PDF pages; page numbers include repository cover; exact original PDF"", ""title"": ""Biosynthetic Characterization of Bacillibactin in Thermophilic Bacillaceae and its Potential for in Vitro Mutational Synthesis"", ""url"": ""https://ir.library.osaka-u.ac.jp/repo/ouka/all/100254/ChemBioChem_cbic.202400836.pdf""}, {""id"": ""metanetx.chemical:MNXM743865"", ""source_sha256"": ""f762cb0962dd4b6802140068b21071ce1433df9a748110526db06b853c2bc6a5"", ""source_version"": ""MNXref production 4.5 per separately retained release page; exact original HTML retrieved 2026-10-11; no versioned bulk dump claimed"", ""title"": ""a 2,3-dihydroxybenzoyl-glycyl-L-threonyl-[DhbF non-ribosomal peptide synthase]"", ""url"": ""https://www.metanetx.org/chem_info/MNXM743865""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-048_d334f5f2e7fe	MetaCyc:RXN-19461	RO:0002234	MetaCyc:DhbF	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DhbF|MetaCyc:RXN-19461	Coefficient 1. Native carrier-state class, not an exact full polypeptide. DhbF contains two CP sites; state coefficients do not count whole NRPS molecules.	"[{""reference_id"": ""MetaCyc:RXN-19461"", ""source_assertion"": ""The native right slot specifies DhbF with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19461\""]/right/*[@frameid=\""DhbF\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:DhbF"", ""source_assertion"": ""This native protein class names the specified covalent carrier state. It does not identify a KH3-4 sequence or establish whole-enzyme stoichiometry."", ""source_locator"": ""Protein[@frameid=\""DhbF\""]/common-name; parent""}]"	"[{""id"": ""MetaCyc:DhbF"", ""source_sha256"": ""e6d402775acc49fc63f147f6a4619631cdc85e1aeb2657cf93305961f30e6c0d"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DhbF"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DhbF""}, {""id"": ""MetaCyc:RXN-19461"", ""source_sha256"": ""909fd360958be5f9e9b590db37d24b0812a2ac127bf2f1c130573c0da3a67ae7"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19461"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19461""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-049_6ff24215ee8e	MetaCyc:RXN-19461	RO:0002234	MetaCyc:PROTON	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PROTON|MetaCyc:RXN-19461	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-19461"", ""source_assertion"": ""The native right slot specifies PROTON with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19461\""]/right/*[@frameid=\""PROTON\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""PROTON\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PROTON"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}, {""id"": ""MetaCyc:RXN-19461"", ""source_sha256"": ""909fd360958be5f9e9b590db37d24b0812a2ac127bf2f1c130573c0da3a67ae7"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19461"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19461""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-050_01e0f3526a71	MetaCyc:RXN-19462	RO:0002233	metanetx.chemical:MNXM743865	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-19462|PMID:39870587|metanetx.chemical:MNXM743865	Coefficient 3. Primary-supported threonyl reactive-state correction under the native transformation identity. The native arginyl frame and imported MNX sameAs are not accepted as exact equivalents. Coefficients count formal carrier states, not whole DhbF polypeptides.	"[{""reference_id"": ""MetaCyc:RXN-19462"", ""source_assertion"": ""The original left slot has coefficient 3 for DHB-glycyl-arginyl-DhbF. That arginyl name conflicts with the threonyl precursor and primary structure; this edge is a curated threonyl correction, not native-equation equivalence."", ""source_locator"": ""Reaction[@frameid=\""RXN-19462\""]/left/Protein; left/coefficient""}, {""reference_id"": ""metanetx.chemical:MNXM743865"", ""source_assertion"": ""The independently issued canonical name is the DHB-glycyl-L-threonyl DhbF state; native SMILES encodes a 2S,3R threonyl thioester and protein-continuation wildcards. It is a reactive class, not an exact full protein or a sameAs claim to the old arginyl frame."", ""source_locator"": ""Unique MolecularEntity JSON-LD: identifier, name, smiles; visible Properties: global charge -1""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""Figure 1b depicts DHB-Gly-L-Thr bound to the second DhbF CP and its trimeric cyclorelease. Figure 5 supports L-Thr selection; Figure 6 detects reconstituted bacillibactin."", ""source_locator"": ""PDF p.4 Figure 1b; p.8 Figure 5; pp.8-9 Figure 6""}]"	"[{""id"": ""MetaCyc:RXN-19462"", ""source_sha256"": ""213cf1c056a7b5df93a8d68c376908b007336aa3be221fb99e1b5921a4893fab"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19462"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19462""}, {""id"": ""PMID:39870587"", ""source_sha256"": ""b0634407933acfa5a161698520e4eb370a73955908b4af913f5c9cae877af86b"", ""source_version"": ""2025 Osaka official accepted manuscript and complete supplement, 30 PDF pages; page numbers include repository cover; exact original PDF"", ""title"": ""Biosynthetic Characterization of Bacillibactin in Thermophilic Bacillaceae and its Potential for in Vitro Mutational Synthesis"", ""url"": ""https://ir.library.osaka-u.ac.jp/repo/ouka/all/100254/ChemBioChem_cbic.202400836.pdf""}, {""id"": ""metanetx.chemical:MNXM743865"", ""source_sha256"": ""f762cb0962dd4b6802140068b21071ce1433df9a748110526db06b853c2bc6a5"", ""source_version"": ""MNXref production 4.5 per separately retained release page; exact original HTML retrieved 2026-10-11; no versioned bulk dump claimed"", ""title"": ""a 2,3-dihydroxybenzoyl-glycyl-L-threonyl-[DhbF non-ribosomal peptide synthase]"", ""url"": ""https://www.metanetx.org/chem_info/MNXM743865""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-051_55f943509f02	MetaCyc:RXN-19462	RO:0002234	MetaCyc:CPD-9984	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-9984|MetaCyc:RXN-19462	Coefficient 1.	"[{""reference_id"": ""MetaCyc:RXN-19462"", ""source_assertion"": ""The native right slot specifies CPD-9984 with coefficient 1. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19462\""]/right/*[@frameid=\""CPD-9984\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-9984"", ""source_assertion"": ""The native compound frame supplies its exact chemical structure, stereochemical InChI and charge; no neutral or unspecified-anomer cross-reference is substituted."", ""source_locator"": ""Compound[@frameid=\""CPD-9984\""]/common-name; cml/molecule; inchi""}]"	"[{""id"": ""MetaCyc:CPD-9984"", ""source_sha256"": ""7acf2bec5e09b32d706f7ab1787f9e8b6105039f76d23da57cbd3cb50191a6cd"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CPD-9984"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-9984""}, {""id"": ""MetaCyc:RXN-19462"", ""source_sha256"": ""213cf1c056a7b5df93a8d68c376908b007336aa3be221fb99e1b5921a4893fab"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19462"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19462""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-052_0275824a5564	MetaCyc:RXN-19462	RO:0002234	MetaCyc:DhbF	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DhbF|MetaCyc:RXN-19462	Coefficient 3. Native carrier-state class, not an exact full polypeptide. DhbF contains two CP sites; state coefficients do not count whole NRPS molecules.	"[{""reference_id"": ""MetaCyc:RXN-19462"", ""source_assertion"": ""The native right slot specifies DhbF with coefficient 3. The source direction is PHYSIOL-LEFT-TO-RIGHT; the displayed side follows the biosynthetic transformation."", ""source_locator"": ""Reaction[@frameid=\""RXN-19462\""]/right/*[@frameid=\""DhbF\""]; right/coefficient; reaction-direction""}, {""reference_id"": ""MetaCyc:DhbF"", ""source_assertion"": ""This native protein class names the specified covalent carrier state. It does not identify a KH3-4 sequence or establish whole-enzyme stoichiometry."", ""source_locator"": ""Protein[@frameid=\""DhbF\""]/common-name; parent""}]"	"[{""id"": ""MetaCyc:DhbF"", ""source_sha256"": ""e6d402775acc49fc63f147f6a4619631cdc85e1aeb2657cf93305961f30e6c0d"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DhbF"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DhbF""}, {""id"": ""MetaCyc:RXN-19462"", ""source_sha256"": ""213cf1c056a7b5df93a8d68c376908b007336aa3be221fb99e1b5921a4893fab"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19462"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19462""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-053_ce2419a9fa39	NCBIProtein:BDG45612.1	pathwaymech:enables	MetaCyc:ISOCHORSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BDG45612.1|PMID:39870587	Annotation-supported KH3-4 gene-product assignment for the complete upstream DHB module. No purified activity or active oligomer is established for this selected protein by the 2025 study.	"[{""reference_id"": ""NCBIProtein:BDG45612.1"", ""source_assertion"": ""The versioned GenPept entry BDG45612.1 identifies Parageobacillus sp. KH3-4, taxon 2916802, and its AP025627.1 coding region. The native gene product is distinguished from tagged experimental constructs and carrier classes."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BDG45612.1\""]/GBSeq_definition; GBSeq_feature-table/GBFeature/GBFeature_quals (coded_by, db_xref, locus_tag)""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""The KH3-4 cluster on AP025627 contains dhbACB assigned to 2,3-DHB production from chorismate. These upstream activities were not individually assayed in the NRPS reconstitution that begins with supplied 2,3-DHB."", ""source_locator"": ""PDF p.4, Results and Discussion, KH3-4 gene cluster; Figure 1a""}, {""reference_id"": ""NCBIProtein:BDG45612.1"", ""source_assertion"": ""The product annotation and similarity-based CDS inference support this proposed upstream activity. They are annotation evidence, not direct purified-enzyme evidence for the selected KH3-4 protein."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BDG45612.1\""]/GBSeq_feature-table/GBFeature/GBFeature_quals (product, inference)""}]"	"[{""id"": ""NCBIProtein:BDG45612.1"", ""source_sha256"": ""02d17fd6734213be23874dee65922ec69c53cf122c85993ae4ce08cd24c23709"", ""source_version"": ""NCBI original complete seven-entry GenPept XML batch; versioned accession; retrieved 2026-10-11; reference hash covers the whole original response"", ""title"": ""isochorismate synthase DhbC [Parageobacillus sp. KH3-4]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BDG45611,BDG45612,BDG45613,BDG45614,BDG45615,BDG45616,BDG45617&rettype=gb&retmode=xml""}, {""id"": ""PMID:39870587"", ""source_sha256"": ""b0634407933acfa5a161698520e4eb370a73955908b4af913f5c9cae877af86b"", ""source_version"": ""2025 Osaka official accepted manuscript and complete supplement, 30 PDF pages; page numbers include repository cover; exact original PDF"", ""title"": ""Biosynthetic Characterization of Bacillibactin in Thermophilic Bacillaceae and its Potential for in Vitro Mutational Synthesis"", ""url"": ""https://ir.library.osaka-u.ac.jp/repo/ouka/all/100254/ChemBioChem_cbic.202400836.pdf""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-054_31a0ec5234ad	NCBIProtein:BDG45614.1	pathwaymech:enables	MetaCyc:ISOCHORMAT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BDG45614.1|PMID:39870587	Annotation-supported KH3-4 gene-product assignment for the complete upstream DHB module. No purified activity or active oligomer is established for this selected protein by the 2025 study.	"[{""reference_id"": ""NCBIProtein:BDG45614.1"", ""source_assertion"": ""The versioned GenPept entry BDG45614.1 identifies Parageobacillus sp. KH3-4, taxon 2916802, and its AP025627.1 coding region. The native gene product is distinguished from tagged experimental constructs and carrier classes."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BDG45614.1\""]/GBSeq_definition; GBSeq_feature-table/GBFeature/GBFeature_quals (coded_by, db_xref, locus_tag)""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""The KH3-4 cluster on AP025627 contains dhbACB assigned to 2,3-DHB production from chorismate. These upstream activities were not individually assayed in the NRPS reconstitution that begins with supplied 2,3-DHB."", ""source_locator"": ""PDF p.4, Results and Discussion, KH3-4 gene cluster; Figure 1a""}, {""reference_id"": ""NCBIProtein:BDG45614.1"", ""source_assertion"": ""The product annotation and similarity-based CDS inference support this proposed upstream activity. They are annotation evidence, not direct purified-enzyme evidence for the selected KH3-4 protein."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BDG45614.1\""]/GBSeq_feature-table/GBFeature/GBFeature_quals (product, inference)""}]"	"[{""id"": ""NCBIProtein:BDG45614.1"", ""source_sha256"": ""02d17fd6734213be23874dee65922ec69c53cf122c85993ae4ce08cd24c23709"", ""source_version"": ""NCBI original complete seven-entry GenPept XML batch; versioned accession; retrieved 2026-10-11; reference hash covers the whole original response"", ""title"": ""isochorismatase [Parageobacillus sp. KH3-4]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BDG45611,BDG45612,BDG45613,BDG45614,BDG45615,BDG45616,BDG45617&rettype=gb&retmode=xml""}, {""id"": ""PMID:39870587"", ""source_sha256"": ""b0634407933acfa5a161698520e4eb370a73955908b4af913f5c9cae877af86b"", ""source_version"": ""2025 Osaka official accepted manuscript and complete supplement, 30 PDF pages; page numbers include repository cover; exact original PDF"", ""title"": ""Biosynthetic Characterization of Bacillibactin in Thermophilic Bacillaceae and its Potential for in Vitro Mutational Synthesis"", ""url"": ""https://ir.library.osaka-u.ac.jp/repo/ouka/all/100254/ChemBioChem_cbic.202400836.pdf""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-055_3582a2006124	NCBIProtein:BDG45611.1	pathwaymech:enables	MetaCyc:DHBDEHYD-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BDG45611.1|PMID:39870587	Annotation-supported KH3-4 gene-product assignment for the complete upstream DHB module. No purified activity or active oligomer is established for this selected protein by the 2025 study.	"[{""reference_id"": ""NCBIProtein:BDG45611.1"", ""source_assertion"": ""The versioned GenPept entry BDG45611.1 identifies Parageobacillus sp. KH3-4, taxon 2916802, and its AP025627.1 coding region. The native gene product is distinguished from tagged experimental constructs and carrier classes."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BDG45611.1\""]/GBSeq_definition; GBSeq_feature-table/GBFeature/GBFeature_quals (coded_by, db_xref, locus_tag)""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""The KH3-4 cluster on AP025627 contains dhbACB assigned to 2,3-DHB production from chorismate. These upstream activities were not individually assayed in the NRPS reconstitution that begins with supplied 2,3-DHB."", ""source_locator"": ""PDF p.4, Results and Discussion, KH3-4 gene cluster; Figure 1a""}, {""reference_id"": ""NCBIProtein:BDG45611.1"", ""source_assertion"": ""The product annotation and similarity-based CDS inference support this proposed upstream activity. They are annotation evidence, not direct purified-enzyme evidence for the selected KH3-4 protein."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BDG45611.1\""]/GBSeq_feature-table/GBFeature/GBFeature_quals (product, inference)""}]"	"[{""id"": ""NCBIProtein:BDG45611.1"", ""source_sha256"": ""02d17fd6734213be23874dee65922ec69c53cf122c85993ae4ce08cd24c23709"", ""source_version"": ""NCBI original complete seven-entry GenPept XML batch; versioned accession; retrieved 2026-10-11; reference hash covers the whole original response"", ""title"": ""2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase [Parageobacillus sp. KH3-4]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BDG45611,BDG45612,BDG45613,BDG45614,BDG45615,BDG45616,BDG45617&rettype=gb&retmode=xml""}, {""id"": ""PMID:39870587"", ""source_sha256"": ""b0634407933acfa5a161698520e4eb370a73955908b4af913f5c9cae877af86b"", ""source_version"": ""2025 Osaka official accepted manuscript and complete supplement, 30 PDF pages; page numbers include repository cover; exact original PDF"", ""title"": ""Biosynthetic Characterization of Bacillibactin in Thermophilic Bacillaceae and its Potential for in Vitro Mutational Synthesis"", ""url"": ""https://ir.library.osaka-u.ac.jp/repo/ouka/all/100254/ChemBioChem_cbic.202400836.pdf""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-056_d65123382428	NCBIProtein:BDG45613.1	pathwaymech:enables	MetaCyc:DHBAMPLIG-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BDG45613.1|PMID:39870587	Functional gene-product role supported by the primary mechanistic model and KH3-4-derived recombinant preparations. This does not establish monomer sufficiency, fixed assembly stoichiometry or separately measured flux for every carrier-bound step.	"[{""reference_id"": ""NCBIProtein:BDG45613.1"", ""source_assertion"": ""The versioned GenPept entry BDG45613.1 identifies Parageobacillus sp. KH3-4, taxon 2916802, and its AP025627.1 coding region. The native gene product is distinguished from tagged experimental constructs and carrier classes."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BDG45613.1\""]/GBSeq_definition; GBSeq_feature-table/GBFeature/GBFeature_quals (coded_by, db_xref, locus_tag)""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""DhbE preferentially activates 2,3-DHB; the loading model transfers the activated acyl group to DhbB. The purified KH3-4-derived preparations support complete NRPS product formation, not a separate kinetic assay of every bound transfer."", ""source_locator"": ""PDF p.4 Figure 1b; pp.7-8 Figure 5 and substrate-specificity paragraphs; pp.8-9 Figure 6""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""Methods explicitly identify BDG45613 as the KH3-4 gene source for the recombinant protein. Tags and coexpression mean the preparation is not claimed to be an independently sequence-verified native full protein."", ""source_locator"": ""PDF p.12, Experimental Section, Plasmid construction; pp.12-13 Production and purification""}]"	"[{""id"": ""NCBIProtein:BDG45613.1"", ""source_sha256"": ""02d17fd6734213be23874dee65922ec69c53cf122c85993ae4ce08cd24c23709"", ""source_version"": ""NCBI original complete seven-entry GenPept XML batch; versioned accession; retrieved 2026-10-11; reference hash covers the whole original response"", ""title"": ""2,3-dihydroxybenzoate-AMP ligase [Parageobacillus sp. KH3-4]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BDG45611,BDG45612,BDG45613,BDG45614,BDG45615,BDG45616,BDG45617&rettype=gb&retmode=xml""}, {""id"": ""PMID:39870587"", ""source_sha256"": ""b0634407933acfa5a161698520e4eb370a73955908b4af913f5c9cae877af86b"", ""source_version"": ""2025 Osaka official accepted manuscript and complete supplement, 30 PDF pages; page numbers include repository cover; exact original PDF"", ""title"": ""Biosynthetic Characterization of Bacillibactin in Thermophilic Bacillaceae and its Potential for in Vitro Mutational Synthesis"", ""url"": ""https://ir.library.osaka-u.ac.jp/repo/ouka/all/100254/ChemBioChem_cbic.202400836.pdf""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-057_61efebaac343	NCBIProtein:BDG45613.1	pathwaymech:enables	MetaCyc:RXN-19449	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BDG45613.1|PMID:39870587	Functional gene-product role supported by the primary mechanistic model and KH3-4-derived recombinant preparations. This does not establish monomer sufficiency, fixed assembly stoichiometry or separately measured flux for every carrier-bound step.	"[{""reference_id"": ""NCBIProtein:BDG45613.1"", ""source_assertion"": ""The versioned GenPept entry BDG45613.1 identifies Parageobacillus sp. KH3-4, taxon 2916802, and its AP025627.1 coding region. The native gene product is distinguished from tagged experimental constructs and carrier classes."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BDG45613.1\""]/GBSeq_definition; GBSeq_feature-table/GBFeature/GBFeature_quals (coded_by, db_xref, locus_tag)""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""DhbE preferentially activates 2,3-DHB; the loading model transfers the activated acyl group to DhbB. The purified KH3-4-derived preparations support complete NRPS product formation, not a separate kinetic assay of every bound transfer."", ""source_locator"": ""PDF p.4 Figure 1b; pp.7-8 Figure 5 and substrate-specificity paragraphs; pp.8-9 Figure 6""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""Methods explicitly identify BDG45613 as the KH3-4 gene source for the recombinant protein. Tags and coexpression mean the preparation is not claimed to be an independently sequence-verified native full protein."", ""source_locator"": ""PDF p.12, Experimental Section, Plasmid construction; pp.12-13 Production and purification""}]"	"[{""id"": ""NCBIProtein:BDG45613.1"", ""source_sha256"": ""02d17fd6734213be23874dee65922ec69c53cf122c85993ae4ce08cd24c23709"", ""source_version"": ""NCBI original complete seven-entry GenPept XML batch; versioned accession; retrieved 2026-10-11; reference hash covers the whole original response"", ""title"": ""2,3-dihydroxybenzoate-AMP ligase [Parageobacillus sp. KH3-4]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BDG45611,BDG45612,BDG45613,BDG45614,BDG45615,BDG45616,BDG45617&rettype=gb&retmode=xml""}, {""id"": ""PMID:39870587"", ""source_sha256"": ""b0634407933acfa5a161698520e4eb370a73955908b4af913f5c9cae877af86b"", ""source_version"": ""2025 Osaka official accepted manuscript and complete supplement, 30 PDF pages; page numbers include repository cover; exact original PDF"", ""title"": ""Biosynthetic Characterization of Bacillibactin in Thermophilic Bacillaceae and its Potential for in Vitro Mutational Synthesis"", ""url"": ""https://ir.library.osaka-u.ac.jp/repo/ouka/all/100254/ChemBioChem_cbic.202400836.pdf""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-058_7e914452f8c7	NCBIProtein:BDG45615.1	pathwaymech:enables	MetaCyc:RXN-9376	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BDG45615.1|PMID:39870587	Functional gene-product role supported by the primary mechanistic model and KH3-4-derived recombinant preparations. This does not establish monomer sufficiency, fixed assembly stoichiometry or separately measured flux for every carrier-bound step.	"[{""reference_id"": ""NCBIProtein:BDG45615.1"", ""source_assertion"": ""The versioned GenPept entry BDG45615.1 identifies Parageobacillus sp. KH3-4, taxon 2916802, and its AP025627.1 coding region. The native gene product is distinguished from tagged experimental constructs and carrier classes."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BDG45615.1\""]/GBSeq_definition; GBSeq_feature-table/GBFeature/GBFeature_quals (coded_by, db_xref, locus_tag)""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""DhbF module 1 prefers glycine and module 2 L-threonine. Figure 1b assigns loading, condensations and TE cyclorelease; purified KH3-4-derived NRPS preparations generate bacillibactin. Not every bound transfer was assayed separately."", ""source_locator"": ""PDF p.4 Figure 1b; pp.7-8 Figure 5 and substrate-specificity paragraphs; pp.8-9 Figure 6""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""Methods explicitly identify BDG45615 as the KH3-4 gene source for the recombinant protein. Tags and coexpression mean the preparation is not claimed to be an independently sequence-verified native full protein."", ""source_locator"": ""PDF p.12, Experimental Section, Plasmid construction; pp.12-13 Production and purification""}]"	"[{""id"": ""NCBIProtein:BDG45615.1"", ""source_sha256"": ""02d17fd6734213be23874dee65922ec69c53cf122c85993ae4ce08cd24c23709"", ""source_version"": ""NCBI original complete seven-entry GenPept XML batch; versioned accession; retrieved 2026-10-11; reference hash covers the whole original response"", ""title"": ""dimodular nonribosomal peptide synthase [Parageobacillus sp. KH3-4]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BDG45611,BDG45612,BDG45613,BDG45614,BDG45615,BDG45616,BDG45617&rettype=gb&retmode=xml""}, {""id"": ""PMID:39870587"", ""source_sha256"": ""b0634407933acfa5a161698520e4eb370a73955908b4af913f5c9cae877af86b"", ""source_version"": ""2025 Osaka official accepted manuscript and complete supplement, 30 PDF pages; page numbers include repository cover; exact original PDF"", ""title"": ""Biosynthetic Characterization of Bacillibactin in Thermophilic Bacillaceae and its Potential for in Vitro Mutational Synthesis"", ""url"": ""https://ir.library.osaka-u.ac.jp/repo/ouka/all/100254/ChemBioChem_cbic.202400836.pdf""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-059_5f3b92d42b01	NCBIProtein:BDG45615.1	pathwaymech:enables	MetaCyc:RXN-19458	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BDG45615.1|PMID:39870587	Functional gene-product role supported by the primary mechanistic model and KH3-4-derived recombinant preparations. This does not establish monomer sufficiency, fixed assembly stoichiometry or separately measured flux for every carrier-bound step.	"[{""reference_id"": ""NCBIProtein:BDG45615.1"", ""source_assertion"": ""The versioned GenPept entry BDG45615.1 identifies Parageobacillus sp. KH3-4, taxon 2916802, and its AP025627.1 coding region. The native gene product is distinguished from tagged experimental constructs and carrier classes."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BDG45615.1\""]/GBSeq_definition; GBSeq_feature-table/GBFeature/GBFeature_quals (coded_by, db_xref, locus_tag)""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""DhbF module 1 prefers glycine and module 2 L-threonine. Figure 1b assigns loading, condensations and TE cyclorelease; purified KH3-4-derived NRPS preparations generate bacillibactin. Not every bound transfer was assayed separately."", ""source_locator"": ""PDF p.4 Figure 1b; pp.7-8 Figure 5 and substrate-specificity paragraphs; pp.8-9 Figure 6""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""Methods explicitly identify BDG45615 as the KH3-4 gene source for the recombinant protein. Tags and coexpression mean the preparation is not claimed to be an independently sequence-verified native full protein."", ""source_locator"": ""PDF p.12, Experimental Section, Plasmid construction; pp.12-13 Production and purification""}]"	"[{""id"": ""NCBIProtein:BDG45615.1"", ""source_sha256"": ""02d17fd6734213be23874dee65922ec69c53cf122c85993ae4ce08cd24c23709"", ""source_version"": ""NCBI original complete seven-entry GenPept XML batch; versioned accession; retrieved 2026-10-11; reference hash covers the whole original response"", ""title"": ""dimodular nonribosomal peptide synthase [Parageobacillus sp. KH3-4]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BDG45611,BDG45612,BDG45613,BDG45614,BDG45615,BDG45616,BDG45617&rettype=gb&retmode=xml""}, {""id"": ""PMID:39870587"", ""source_sha256"": ""b0634407933acfa5a161698520e4eb370a73955908b4af913f5c9cae877af86b"", ""source_version"": ""2025 Osaka official accepted manuscript and complete supplement, 30 PDF pages; page numbers include repository cover; exact original PDF"", ""title"": ""Biosynthetic Characterization of Bacillibactin in Thermophilic Bacillaceae and its Potential for in Vitro Mutational Synthesis"", ""url"": ""https://ir.library.osaka-u.ac.jp/repo/ouka/all/100254/ChemBioChem_cbic.202400836.pdf""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-060_15930a7e6d9f	NCBIProtein:BDG45615.1	pathwaymech:enables	MetaCyc:RXN-19460	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BDG45615.1|PMID:39870587	Functional gene-product role supported by the primary mechanistic model and KH3-4-derived recombinant preparations. This does not establish monomer sufficiency, fixed assembly stoichiometry or separately measured flux for every carrier-bound step.	"[{""reference_id"": ""NCBIProtein:BDG45615.1"", ""source_assertion"": ""The versioned GenPept entry BDG45615.1 identifies Parageobacillus sp. KH3-4, taxon 2916802, and its AP025627.1 coding region. The native gene product is distinguished from tagged experimental constructs and carrier classes."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BDG45615.1\""]/GBSeq_definition; GBSeq_feature-table/GBFeature/GBFeature_quals (coded_by, db_xref, locus_tag)""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""DhbF module 1 prefers glycine and module 2 L-threonine. Figure 1b assigns loading, condensations and TE cyclorelease; purified KH3-4-derived NRPS preparations generate bacillibactin. Not every bound transfer was assayed separately."", ""source_locator"": ""PDF p.4 Figure 1b; pp.7-8 Figure 5 and substrate-specificity paragraphs; pp.8-9 Figure 6""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""Methods explicitly identify BDG45615 as the KH3-4 gene source for the recombinant protein. Tags and coexpression mean the preparation is not claimed to be an independently sequence-verified native full protein."", ""source_locator"": ""PDF p.12, Experimental Section, Plasmid construction; pp.12-13 Production and purification""}]"	"[{""id"": ""NCBIProtein:BDG45615.1"", ""source_sha256"": ""02d17fd6734213be23874dee65922ec69c53cf122c85993ae4ce08cd24c23709"", ""source_version"": ""NCBI original complete seven-entry GenPept XML batch; versioned accession; retrieved 2026-10-11; reference hash covers the whole original response"", ""title"": ""dimodular nonribosomal peptide synthase [Parageobacillus sp. KH3-4]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BDG45611,BDG45612,BDG45613,BDG45614,BDG45615,BDG45616,BDG45617&rettype=gb&retmode=xml""}, {""id"": ""PMID:39870587"", ""source_sha256"": ""b0634407933acfa5a161698520e4eb370a73955908b4af913f5c9cae877af86b"", ""source_version"": ""2025 Osaka official accepted manuscript and complete supplement, 30 PDF pages; page numbers include repository cover; exact original PDF"", ""title"": ""Biosynthetic Characterization of Bacillibactin in Thermophilic Bacillaceae and its Potential for in Vitro Mutational Synthesis"", ""url"": ""https://ir.library.osaka-u.ac.jp/repo/ouka/all/100254/ChemBioChem_cbic.202400836.pdf""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-061_9b342d422716	NCBIProtein:BDG45615.1	pathwaymech:enables	MetaCyc:RXN-9377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BDG45615.1|PMID:39870587	Functional gene-product role supported by the primary mechanistic model and KH3-4-derived recombinant preparations. This does not establish monomer sufficiency, fixed assembly stoichiometry or separately measured flux for every carrier-bound step.	"[{""reference_id"": ""NCBIProtein:BDG45615.1"", ""source_assertion"": ""The versioned GenPept entry BDG45615.1 identifies Parageobacillus sp. KH3-4, taxon 2916802, and its AP025627.1 coding region. The native gene product is distinguished from tagged experimental constructs and carrier classes."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BDG45615.1\""]/GBSeq_definition; GBSeq_feature-table/GBFeature/GBFeature_quals (coded_by, db_xref, locus_tag)""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""DhbF module 1 prefers glycine and module 2 L-threonine. Figure 1b assigns loading, condensations and TE cyclorelease; purified KH3-4-derived NRPS preparations generate bacillibactin. Not every bound transfer was assayed separately."", ""source_locator"": ""PDF p.4 Figure 1b; pp.7-8 Figure 5 and substrate-specificity paragraphs; pp.8-9 Figure 6""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""Methods explicitly identify BDG45615 as the KH3-4 gene source for the recombinant protein. Tags and coexpression mean the preparation is not claimed to be an independently sequence-verified native full protein."", ""source_locator"": ""PDF p.12, Experimental Section, Plasmid construction; pp.12-13 Production and purification""}]"	"[{""id"": ""NCBIProtein:BDG45615.1"", ""source_sha256"": ""02d17fd6734213be23874dee65922ec69c53cf122c85993ae4ce08cd24c23709"", ""source_version"": ""NCBI original complete seven-entry GenPept XML batch; versioned accession; retrieved 2026-10-11; reference hash covers the whole original response"", ""title"": ""dimodular nonribosomal peptide synthase [Parageobacillus sp. KH3-4]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BDG45611,BDG45612,BDG45613,BDG45614,BDG45615,BDG45616,BDG45617&rettype=gb&retmode=xml""}, {""id"": ""PMID:39870587"", ""source_sha256"": ""b0634407933acfa5a161698520e4eb370a73955908b4af913f5c9cae877af86b"", ""source_version"": ""2025 Osaka official accepted manuscript and complete supplement, 30 PDF pages; page numbers include repository cover; exact original PDF"", ""title"": ""Biosynthetic Characterization of Bacillibactin in Thermophilic Bacillaceae and its Potential for in Vitro Mutational Synthesis"", ""url"": ""https://ir.library.osaka-u.ac.jp/repo/ouka/all/100254/ChemBioChem_cbic.202400836.pdf""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-062_9017bcadb4bf	NCBIProtein:BDG45615.1	pathwaymech:enables	MetaCyc:RXN-19452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BDG45615.1|PMID:39870587	Functional gene-product role supported by the primary mechanistic model and KH3-4-derived recombinant preparations. This does not establish monomer sufficiency, fixed assembly stoichiometry or separately measured flux for every carrier-bound step.	"[{""reference_id"": ""NCBIProtein:BDG45615.1"", ""source_assertion"": ""The versioned GenPept entry BDG45615.1 identifies Parageobacillus sp. KH3-4, taxon 2916802, and its AP025627.1 coding region. The native gene product is distinguished from tagged experimental constructs and carrier classes."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BDG45615.1\""]/GBSeq_definition; GBSeq_feature-table/GBFeature/GBFeature_quals (coded_by, db_xref, locus_tag)""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""DhbF module 1 prefers glycine and module 2 L-threonine. Figure 1b assigns loading, condensations and TE cyclorelease; purified KH3-4-derived NRPS preparations generate bacillibactin. Not every bound transfer was assayed separately."", ""source_locator"": ""PDF p.4 Figure 1b; pp.7-8 Figure 5 and substrate-specificity paragraphs; pp.8-9 Figure 6""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""Methods explicitly identify BDG45615 as the KH3-4 gene source for the recombinant protein. Tags and coexpression mean the preparation is not claimed to be an independently sequence-verified native full protein."", ""source_locator"": ""PDF p.12, Experimental Section, Plasmid construction; pp.12-13 Production and purification""}]"	"[{""id"": ""NCBIProtein:BDG45615.1"", ""source_sha256"": ""02d17fd6734213be23874dee65922ec69c53cf122c85993ae4ce08cd24c23709"", ""source_version"": ""NCBI original complete seven-entry GenPept XML batch; versioned accession; retrieved 2026-10-11; reference hash covers the whole original response"", ""title"": ""dimodular nonribosomal peptide synthase [Parageobacillus sp. KH3-4]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BDG45611,BDG45612,BDG45613,BDG45614,BDG45615,BDG45616,BDG45617&rettype=gb&retmode=xml""}, {""id"": ""PMID:39870587"", ""source_sha256"": ""b0634407933acfa5a161698520e4eb370a73955908b4af913f5c9cae877af86b"", ""source_version"": ""2025 Osaka official accepted manuscript and complete supplement, 30 PDF pages; page numbers include repository cover; exact original PDF"", ""title"": ""Biosynthetic Characterization of Bacillibactin in Thermophilic Bacillaceae and its Potential for in Vitro Mutational Synthesis"", ""url"": ""https://ir.library.osaka-u.ac.jp/repo/ouka/all/100254/ChemBioChem_cbic.202400836.pdf""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-063_087ccc4d8b24	NCBIProtein:BDG45615.1	pathwaymech:enables	MetaCyc:RXN-19461	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BDG45615.1|PMID:39870587	Functional gene-product role supported by the primary mechanistic model and KH3-4-derived recombinant preparations. This does not establish monomer sufficiency, fixed assembly stoichiometry or separately measured flux for every carrier-bound step.	"[{""reference_id"": ""NCBIProtein:BDG45615.1"", ""source_assertion"": ""The versioned GenPept entry BDG45615.1 identifies Parageobacillus sp. KH3-4, taxon 2916802, and its AP025627.1 coding region. The native gene product is distinguished from tagged experimental constructs and carrier classes."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BDG45615.1\""]/GBSeq_definition; GBSeq_feature-table/GBFeature/GBFeature_quals (coded_by, db_xref, locus_tag)""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""DhbF module 1 prefers glycine and module 2 L-threonine. Figure 1b assigns loading, condensations and TE cyclorelease; purified KH3-4-derived NRPS preparations generate bacillibactin. Not every bound transfer was assayed separately."", ""source_locator"": ""PDF p.4 Figure 1b; pp.7-8 Figure 5 and substrate-specificity paragraphs; pp.8-9 Figure 6""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""Methods explicitly identify BDG45615 as the KH3-4 gene source for the recombinant protein. Tags and coexpression mean the preparation is not claimed to be an independently sequence-verified native full protein."", ""source_locator"": ""PDF p.12, Experimental Section, Plasmid construction; pp.12-13 Production and purification""}]"	"[{""id"": ""NCBIProtein:BDG45615.1"", ""source_sha256"": ""02d17fd6734213be23874dee65922ec69c53cf122c85993ae4ce08cd24c23709"", ""source_version"": ""NCBI original complete seven-entry GenPept XML batch; versioned accession; retrieved 2026-10-11; reference hash covers the whole original response"", ""title"": ""dimodular nonribosomal peptide synthase [Parageobacillus sp. KH3-4]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BDG45611,BDG45612,BDG45613,BDG45614,BDG45615,BDG45616,BDG45617&rettype=gb&retmode=xml""}, {""id"": ""PMID:39870587"", ""source_sha256"": ""b0634407933acfa5a161698520e4eb370a73955908b4af913f5c9cae877af86b"", ""source_version"": ""2025 Osaka official accepted manuscript and complete supplement, 30 PDF pages; page numbers include repository cover; exact original PDF"", ""title"": ""Biosynthetic Characterization of Bacillibactin in Thermophilic Bacillaceae and its Potential for in Vitro Mutational Synthesis"", ""url"": ""https://ir.library.osaka-u.ac.jp/repo/ouka/all/100254/ChemBioChem_cbic.202400836.pdf""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-064_8039ed1594cf	NCBIProtein:BDG45615.1	pathwaymech:enables	MetaCyc:RXN-19462	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BDG45615.1|PMID:39870587	Functional gene-product role supported by the primary mechanistic model and KH3-4-derived recombinant preparations. This does not establish monomer sufficiency, fixed assembly stoichiometry or separately measured flux for every carrier-bound step.	"[{""reference_id"": ""NCBIProtein:BDG45615.1"", ""source_assertion"": ""The versioned GenPept entry BDG45615.1 identifies Parageobacillus sp. KH3-4, taxon 2916802, and its AP025627.1 coding region. The native gene product is distinguished from tagged experimental constructs and carrier classes."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BDG45615.1\""]/GBSeq_definition; GBSeq_feature-table/GBFeature/GBFeature_quals (coded_by, db_xref, locus_tag)""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""DhbF module 1 prefers glycine and module 2 L-threonine. Figure 1b assigns loading, condensations and TE cyclorelease; purified KH3-4-derived NRPS preparations generate bacillibactin. Not every bound transfer was assayed separately."", ""source_locator"": ""PDF p.4 Figure 1b; pp.7-8 Figure 5 and substrate-specificity paragraphs; pp.8-9 Figure 6""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""Methods explicitly identify BDG45615 as the KH3-4 gene source for the recombinant protein. Tags and coexpression mean the preparation is not claimed to be an independently sequence-verified native full protein."", ""source_locator"": ""PDF p.12, Experimental Section, Plasmid construction; pp.12-13 Production and purification""}]"	"[{""id"": ""NCBIProtein:BDG45615.1"", ""source_sha256"": ""02d17fd6734213be23874dee65922ec69c53cf122c85993ae4ce08cd24c23709"", ""source_version"": ""NCBI original complete seven-entry GenPept XML batch; versioned accession; retrieved 2026-10-11; reference hash covers the whole original response"", ""title"": ""dimodular nonribosomal peptide synthase [Parageobacillus sp. KH3-4]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BDG45611,BDG45612,BDG45613,BDG45614,BDG45615,BDG45616,BDG45617&rettype=gb&retmode=xml""}, {""id"": ""PMID:39870587"", ""source_sha256"": ""b0634407933acfa5a161698520e4eb370a73955908b4af913f5c9cae877af86b"", ""source_version"": ""2025 Osaka official accepted manuscript and complete supplement, 30 PDF pages; page numbers include repository cover; exact original PDF"", ""title"": ""Biosynthetic Characterization of Bacillibactin in Thermophilic Bacillaceae and its Potential for in Vitro Mutational Synthesis"", ""url"": ""https://ir.library.osaka-u.ac.jp/repo/ouka/all/100254/ChemBioChem_cbic.202400836.pdf""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-065_f1a5d89d4f2c	MetaCyc:ISOCHORSYN-RXN	BFO:0000050	MetaCyc:PWY-5903	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5901|MetaCyc:PWY-5903		"[{""reference_id"": ""MetaCyc:PWY-5901"", ""source_assertion"": ""The original reaction-list includes ISOCHORSYN-RXN; this complete module member is retained in the chorismate-to-bacillibactin route."", ""source_locator"": ""Pathway[@frameid=\""PWY-5901\""]/reaction-list/Reaction""}, {""reference_id"": ""MetaCyc:PWY-5903"", ""source_assertion"": ""PWY-5903 explicitly includes PWY-5901 as its upstream nested pathway."", ""source_locator"": ""Pathway[@frameid=\""PWY-5903\""]/reaction-list/Pathway""}]"	"[{""id"": ""MetaCyc:PWY-5901"", ""source_sha256"": ""2b978bba42064a27efcf351934b22c6c0fa9c335e1f24965cc70897daf22427c"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-5901"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5901""}, {""id"": ""MetaCyc:PWY-5903"", ""source_sha256"": ""d4b7972f8f68c91253360395c7d2499efb3b43111061121f5b31d0e391a79b5e"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-5903"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5903""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-066_9c329097800b	MetaCyc:ISOCHORMAT-RXN	BFO:0000050	MetaCyc:PWY-5903	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5901|MetaCyc:PWY-5903		"[{""reference_id"": ""MetaCyc:PWY-5901"", ""source_assertion"": ""The original reaction-list includes ISOCHORMAT-RXN; this complete module member is retained in the chorismate-to-bacillibactin route."", ""source_locator"": ""Pathway[@frameid=\""PWY-5901\""]/reaction-list/Reaction""}, {""reference_id"": ""MetaCyc:PWY-5903"", ""source_assertion"": ""PWY-5903 explicitly includes PWY-5901 as its upstream nested pathway."", ""source_locator"": ""Pathway[@frameid=\""PWY-5903\""]/reaction-list/Pathway""}]"	"[{""id"": ""MetaCyc:PWY-5901"", ""source_sha256"": ""2b978bba42064a27efcf351934b22c6c0fa9c335e1f24965cc70897daf22427c"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-5901"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5901""}, {""id"": ""MetaCyc:PWY-5903"", ""source_sha256"": ""d4b7972f8f68c91253360395c7d2499efb3b43111061121f5b31d0e391a79b5e"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-5903"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5903""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-067_1a7d292487fd	MetaCyc:DHBDEHYD-RXN	BFO:0000050	MetaCyc:PWY-5903	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5901|MetaCyc:PWY-5903		"[{""reference_id"": ""MetaCyc:PWY-5901"", ""source_assertion"": ""The original reaction-list includes DHBDEHYD-RXN; this complete module member is retained in the chorismate-to-bacillibactin route."", ""source_locator"": ""Pathway[@frameid=\""PWY-5901\""]/reaction-list/Reaction""}, {""reference_id"": ""MetaCyc:PWY-5903"", ""source_assertion"": ""PWY-5903 explicitly includes PWY-5901 as its upstream nested pathway."", ""source_locator"": ""Pathway[@frameid=\""PWY-5903\""]/reaction-list/Pathway""}]"	"[{""id"": ""MetaCyc:PWY-5901"", ""source_sha256"": ""2b978bba42064a27efcf351934b22c6c0fa9c335e1f24965cc70897daf22427c"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-5901"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5901""}, {""id"": ""MetaCyc:PWY-5903"", ""source_sha256"": ""d4b7972f8f68c91253360395c7d2499efb3b43111061121f5b31d0e391a79b5e"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-5903"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5903""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-068_3516f59552ce	MetaCyc:DHBAMPLIG-RXN	BFO:0000050	MetaCyc:PWY-5903	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5903		"[{""reference_id"": ""MetaCyc:PWY-5903"", ""source_assertion"": ""The original reaction-list includes DHBAMPLIG-RXN; this complete module member is retained in the chorismate-to-bacillibactin route."", ""source_locator"": ""Pathway[@frameid=\""PWY-5903\""]/reaction-list/Reaction""}]"	"[{""id"": ""MetaCyc:PWY-5903"", ""source_sha256"": ""d4b7972f8f68c91253360395c7d2499efb3b43111061121f5b31d0e391a79b5e"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-5903"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5903""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-069_b5aa1956c431	MetaCyc:RXN-19449	BFO:0000050	MetaCyc:PWY-5903	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5903		"[{""reference_id"": ""MetaCyc:PWY-5903"", ""source_assertion"": ""The original reaction-list includes RXN-19449; this complete module member is retained in the chorismate-to-bacillibactin route."", ""source_locator"": ""Pathway[@frameid=\""PWY-5903\""]/reaction-list/Reaction""}]"	"[{""id"": ""MetaCyc:PWY-5903"", ""source_sha256"": ""d4b7972f8f68c91253360395c7d2499efb3b43111061121f5b31d0e391a79b5e"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-5903"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5903""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-070_898d816599eb	MetaCyc:RXN-9376	BFO:0000050	MetaCyc:PWY-5903	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5903		"[{""reference_id"": ""MetaCyc:PWY-5903"", ""source_assertion"": ""The original reaction-list includes RXN-9376; this complete module member is retained in the chorismate-to-bacillibactin route."", ""source_locator"": ""Pathway[@frameid=\""PWY-5903\""]/reaction-list/Reaction""}]"	"[{""id"": ""MetaCyc:PWY-5903"", ""source_sha256"": ""d4b7972f8f68c91253360395c7d2499efb3b43111061121f5b31d0e391a79b5e"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-5903"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5903""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-071_95cd3f967cfe	MetaCyc:RXN-19458	BFO:0000050	MetaCyc:PWY-5903	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5903		"[{""reference_id"": ""MetaCyc:PWY-5903"", ""source_assertion"": ""The original reaction-list includes RXN-19458; this complete module member is retained in the chorismate-to-bacillibactin route."", ""source_locator"": ""Pathway[@frameid=\""PWY-5903\""]/reaction-list/Reaction""}]"	"[{""id"": ""MetaCyc:PWY-5903"", ""source_sha256"": ""d4b7972f8f68c91253360395c7d2499efb3b43111061121f5b31d0e391a79b5e"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-5903"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5903""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-072_fe6b7c72d10c	MetaCyc:RXN-19460	BFO:0000050	MetaCyc:PWY-5903	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5903		"[{""reference_id"": ""MetaCyc:PWY-5903"", ""source_assertion"": ""The original reaction-list includes RXN-19460; this complete module member is retained in the chorismate-to-bacillibactin route."", ""source_locator"": ""Pathway[@frameid=\""PWY-5903\""]/reaction-list/Reaction""}]"	"[{""id"": ""MetaCyc:PWY-5903"", ""source_sha256"": ""d4b7972f8f68c91253360395c7d2499efb3b43111061121f5b31d0e391a79b5e"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-5903"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5903""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-073_4521c66e915e	MetaCyc:RXN-9377	BFO:0000050	MetaCyc:PWY-5903	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5903		"[{""reference_id"": ""MetaCyc:PWY-5903"", ""source_assertion"": ""The original reaction-list includes RXN-9377; this complete module member is retained in the chorismate-to-bacillibactin route."", ""source_locator"": ""Pathway[@frameid=\""PWY-5903\""]/reaction-list/Reaction""}]"	"[{""id"": ""MetaCyc:PWY-5903"", ""source_sha256"": ""d4b7972f8f68c91253360395c7d2499efb3b43111061121f5b31d0e391a79b5e"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-5903"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5903""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-074_f24dec7b0bc6	MetaCyc:RXN-19452	BFO:0000050	MetaCyc:PWY-5903	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5903		"[{""reference_id"": ""MetaCyc:PWY-5903"", ""source_assertion"": ""The original reaction-list includes RXN-19452; this complete module member is retained in the chorismate-to-bacillibactin route."", ""source_locator"": ""Pathway[@frameid=\""PWY-5903\""]/reaction-list/Reaction""}]"	"[{""id"": ""MetaCyc:PWY-5903"", ""source_sha256"": ""d4b7972f8f68c91253360395c7d2499efb3b43111061121f5b31d0e391a79b5e"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-5903"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5903""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-075_68563ec7aa10	MetaCyc:RXN-19461	BFO:0000050	MetaCyc:PWY-5903	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5903		"[{""reference_id"": ""MetaCyc:PWY-5903"", ""source_assertion"": ""The original reaction-list includes RXN-19461; this complete module member is retained in the chorismate-to-bacillibactin route."", ""source_locator"": ""Pathway[@frameid=\""PWY-5903\""]/reaction-list/Reaction""}]"	"[{""id"": ""MetaCyc:PWY-5903"", ""source_sha256"": ""d4b7972f8f68c91253360395c7d2499efb3b43111061121f5b31d0e391a79b5e"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-5903"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5903""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-076_e964a5defe89	MetaCyc:RXN-19462	BFO:0000050	MetaCyc:PWY-5903	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5903		"[{""reference_id"": ""MetaCyc:PWY-5903"", ""source_assertion"": ""The original reaction-list includes RXN-19462; this complete module member is retained in the chorismate-to-bacillibactin route."", ""source_locator"": ""Pathway[@frameid=\""PWY-5903\""]/reaction-list/Reaction""}]"	"[{""id"": ""MetaCyc:PWY-5903"", ""source_sha256"": ""d4b7972f8f68c91253360395c7d2499efb3b43111061121f5b31d0e391a79b5e"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-5903"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5903""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-077_f405dcdbff1d	MetaCyc:ISOCHORSYN-RXN	RO:0002413	MetaCyc:ISOCHORMAT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ISOCHORMAT-RXN|MetaCyc:ISOCHORSYN-RXN	Shared intermediate: MetaCyc:ISOCHORISMATE. This is a chemical handoff, not an assertion of physical channeling or a single linear activation order.	"[{""reference_id"": ""MetaCyc:ISOCHORSYN-RXN"", ""source_assertion"": ""The native product slot contains ISOCHORISMATE."", ""source_locator"": ""Reaction[@frameid=\""ISOCHORSYN-RXN\""]/right/*[@frameid=\""ISOCHORISMATE\""]""}, {""reference_id"": ""MetaCyc:ISOCHORMAT-RXN"", ""source_assertion"": ""The native substrate slot contains ISOCHORISMATE."", ""source_locator"": ""Reaction[@frameid=\""ISOCHORMAT-RXN\""]/left/*[@frameid=\""ISOCHORISMATE\""]""}]"	"[{""id"": ""MetaCyc:ISOCHORMAT-RXN"", ""source_sha256"": ""17750d21f912eb41d92fa0e73773cf03caa447c64bcf1467fda491f69175c76c"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native ISOCHORMAT-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ISOCHORMAT-RXN""}, {""id"": ""MetaCyc:ISOCHORSYN-RXN"", ""source_sha256"": ""12b0f7a51414fd2dc6ea14d9596d9cc7f0fcc121d0843c434e3ae5b23af90198"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native ISOCHORSYN-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ISOCHORSYN-RXN""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-078_47e2bf4814f0	MetaCyc:ISOCHORMAT-RXN	RO:0002413	MetaCyc:DHBDEHYD-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DHBDEHYD-RXN|MetaCyc:ISOCHORMAT-RXN	Shared intermediate: MetaCyc:DIHYDRO-DIOH-BENZOATE. This is a chemical handoff, not an assertion of physical channeling or a single linear activation order.	"[{""reference_id"": ""MetaCyc:ISOCHORMAT-RXN"", ""source_assertion"": ""The native product slot contains DIHYDRO-DIOH-BENZOATE."", ""source_locator"": ""Reaction[@frameid=\""ISOCHORMAT-RXN\""]/right/*[@frameid=\""DIHYDRO-DIOH-BENZOATE\""]""}, {""reference_id"": ""MetaCyc:DHBDEHYD-RXN"", ""source_assertion"": ""The native substrate slot contains DIHYDRO-DIOH-BENZOATE."", ""source_locator"": ""Reaction[@frameid=\""DHBDEHYD-RXN\""]/left/*[@frameid=\""DIHYDRO-DIOH-BENZOATE\""]""}]"	"[{""id"": ""MetaCyc:DHBDEHYD-RXN"", ""source_sha256"": ""e694e624fe8f8d1690686a60f51bed77323eb276f5ccecf67ecc9860c83de4e0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DHBDEHYD-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHBDEHYD-RXN""}, {""id"": ""MetaCyc:ISOCHORMAT-RXN"", ""source_sha256"": ""17750d21f912eb41d92fa0e73773cf03caa447c64bcf1467fda491f69175c76c"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native ISOCHORMAT-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ISOCHORMAT-RXN""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-079_7392c81d1878	MetaCyc:DHBDEHYD-RXN	RO:0002413	MetaCyc:DHBAMPLIG-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DHBAMPLIG-RXN|MetaCyc:DHBDEHYD-RXN	Shared intermediate: MetaCyc:2-3-DIHYDROXYBENZOATE. This is a chemical handoff, not an assertion of physical channeling or a single linear activation order.	"[{""reference_id"": ""MetaCyc:DHBDEHYD-RXN"", ""source_assertion"": ""The native product slot contains 2-3-DIHYDROXYBENZOATE."", ""source_locator"": ""Reaction[@frameid=\""DHBDEHYD-RXN\""]/right/*[@frameid=\""2-3-DIHYDROXYBENZOATE\""]""}, {""reference_id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_assertion"": ""The native substrate slot contains 2-3-DIHYDROXYBENZOATE."", ""source_locator"": ""Reaction[@frameid=\""DHBAMPLIG-RXN\""]/left/*[@frameid=\""2-3-DIHYDROXYBENZOATE\""]""}]"	"[{""id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_sha256"": ""baf9b7ffbe51f1f2bf07f3717b39891fbece11f323b0ad68687b4c9dba0ae6e0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DHBAMPLIG-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHBAMPLIG-RXN""}, {""id"": ""MetaCyc:DHBDEHYD-RXN"", ""source_sha256"": ""e694e624fe8f8d1690686a60f51bed77323eb276f5ccecf67ecc9860c83de4e0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DHBDEHYD-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHBDEHYD-RXN""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-080_ff1fc1e31541	MetaCyc:DHBAMPLIG-RXN	RO:0002413	MetaCyc:RXN-19449	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DHBAMPLIG-RXN|MetaCyc:RXN-19449	Shared intermediate: MetaCyc:CPD-62. This is a chemical handoff, not an assertion of physical channeling or a single linear activation order.	"[{""reference_id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_assertion"": ""The native product slot contains CPD-62."", ""source_locator"": ""Reaction[@frameid=\""DHBAMPLIG-RXN\""]/right/*[@frameid=\""CPD-62\""]""}, {""reference_id"": ""MetaCyc:RXN-19449"", ""source_assertion"": ""The native substrate slot contains CPD-62."", ""source_locator"": ""Reaction[@frameid=\""RXN-19449\""]/left/*[@frameid=\""CPD-62\""]""}]"	"[{""id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_sha256"": ""baf9b7ffbe51f1f2bf07f3717b39891fbece11f323b0ad68687b4c9dba0ae6e0"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native DHBAMPLIG-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHBAMPLIG-RXN""}, {""id"": ""MetaCyc:RXN-19449"", ""source_sha256"": ""b7bc71f61ecb21cbfb23ad1d77ab11efd5d82e8e48b6b16304ee9a6cae7f1706"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19449"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19449""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-081_bb2ed9ac1ff4	MetaCyc:RXN-19449	RO:0002413	MetaCyc:RXN-19460	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-19449|MetaCyc:RXN-19460	Shared intermediate: MetaCyc:23-dihydroxybenzoyl-DhbB. This is a chemical handoff, not an assertion of physical channeling or a single linear activation order.	"[{""reference_id"": ""MetaCyc:RXN-19449"", ""source_assertion"": ""The native product slot contains 23-dihydroxybenzoyl-DhbB."", ""source_locator"": ""Reaction[@frameid=\""RXN-19449\""]/right/*[@frameid=\""23-dihydroxybenzoyl-DhbB\""]""}, {""reference_id"": ""MetaCyc:RXN-19460"", ""source_assertion"": ""The native substrate slot contains 23-dihydroxybenzoyl-DhbB."", ""source_locator"": ""Reaction[@frameid=\""RXN-19460\""]/left/*[@frameid=\""23-dihydroxybenzoyl-DhbB\""]""}]"	"[{""id"": ""MetaCyc:RXN-19449"", ""source_sha256"": ""b7bc71f61ecb21cbfb23ad1d77ab11efd5d82e8e48b6b16304ee9a6cae7f1706"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19449"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19449""}, {""id"": ""MetaCyc:RXN-19460"", ""source_sha256"": ""d776387c9ec242d9cfe26c8dd6b36b58d61aaf4e6e7cadf21bfe2084edee5424"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19460"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19460""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-082_66d3eb40c43e	MetaCyc:RXN-9376	RO:0002413	MetaCyc:RXN-19458	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-19458|MetaCyc:RXN-9376	Shared intermediate: MetaCyc:CPD-9993. This is a chemical handoff, not an assertion of physical channeling or a single linear activation order.	"[{""reference_id"": ""MetaCyc:RXN-9376"", ""source_assertion"": ""The native product slot contains CPD-9993."", ""source_locator"": ""Reaction[@frameid=\""RXN-9376\""]/right/*[@frameid=\""CPD-9993\""]""}, {""reference_id"": ""MetaCyc:RXN-19458"", ""source_assertion"": ""The native substrate slot contains CPD-9993."", ""source_locator"": ""Reaction[@frameid=\""RXN-19458\""]/left/*[@frameid=\""CPD-9993\""]""}]"	"[{""id"": ""MetaCyc:RXN-19458"", ""source_sha256"": ""ca9d5ecd07429de09a00e16885b4d009f995b8d7ae46b2edbf92475c52af9c63"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19458"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19458""}, {""id"": ""MetaCyc:RXN-9376"", ""source_sha256"": ""ab65ede5c40dc212695a9679d98f6834490ddc565be8bc1e0b6ff43906e49791"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-9376"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9376""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-083_b3fc430cb0f9	MetaCyc:RXN-19458	RO:0002413	MetaCyc:RXN-19460	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-19458|MetaCyc:RXN-19460	Shared intermediate: MetaCyc:Glycyl-DhbF. This is a chemical handoff, not an assertion of physical channeling or a single linear activation order.	"[{""reference_id"": ""MetaCyc:RXN-19458"", ""source_assertion"": ""The native product slot contains Glycyl-DhbF."", ""source_locator"": ""Reaction[@frameid=\""RXN-19458\""]/right/*[@frameid=\""Glycyl-DhbF\""]""}, {""reference_id"": ""MetaCyc:RXN-19460"", ""source_assertion"": ""The native substrate slot contains Glycyl-DhbF."", ""source_locator"": ""Reaction[@frameid=\""RXN-19460\""]/left/*[@frameid=\""Glycyl-DhbF\""]""}]"	"[{""id"": ""MetaCyc:RXN-19458"", ""source_sha256"": ""ca9d5ecd07429de09a00e16885b4d009f995b8d7ae46b2edbf92475c52af9c63"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19458"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19458""}, {""id"": ""MetaCyc:RXN-19460"", ""source_sha256"": ""d776387c9ec242d9cfe26c8dd6b36b58d61aaf4e6e7cadf21bfe2084edee5424"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19460"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19460""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-084_14531db81b82	MetaCyc:RXN-19460	RO:0002413	MetaCyc:RXN-19461	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-19460|MetaCyc:RXN-19461	Shared intermediate: MetaCyc:DHB-glycyl-DhbF. This is a chemical handoff, not an assertion of physical channeling or a single linear activation order.	"[{""reference_id"": ""MetaCyc:RXN-19460"", ""source_assertion"": ""The native product slot contains DHB-glycyl-DhbF."", ""source_locator"": ""Reaction[@frameid=\""RXN-19460\""]/right/*[@frameid=\""DHB-glycyl-DhbF\""]""}, {""reference_id"": ""MetaCyc:RXN-19461"", ""source_assertion"": ""The native substrate slot contains DHB-glycyl-DhbF."", ""source_locator"": ""Reaction[@frameid=\""RXN-19461\""]/left/*[@frameid=\""DHB-glycyl-DhbF\""]""}]"	"[{""id"": ""MetaCyc:RXN-19460"", ""source_sha256"": ""d776387c9ec242d9cfe26c8dd6b36b58d61aaf4e6e7cadf21bfe2084edee5424"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19460"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19460""}, {""id"": ""MetaCyc:RXN-19461"", ""source_sha256"": ""909fd360958be5f9e9b590db37d24b0812a2ac127bf2f1c130573c0da3a67ae7"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19461"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19461""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-085_63984168ffc8	MetaCyc:RXN-9377	RO:0002413	MetaCyc:RXN-19452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-19452|MetaCyc:RXN-9377	Shared intermediate: MetaCyc:CPD-9994. This is a chemical handoff, not an assertion of physical channeling or a single linear activation order.	"[{""reference_id"": ""MetaCyc:RXN-9377"", ""source_assertion"": ""The native product slot contains CPD-9994."", ""source_locator"": ""Reaction[@frameid=\""RXN-9377\""]/right/*[@frameid=\""CPD-9994\""]""}, {""reference_id"": ""MetaCyc:RXN-19452"", ""source_assertion"": ""The native substrate slot contains CPD-9994."", ""source_locator"": ""Reaction[@frameid=\""RXN-19452\""]/left/*[@frameid=\""CPD-9994\""]""}]"	"[{""id"": ""MetaCyc:RXN-19452"", ""source_sha256"": ""d2d9608e4dbf6136419a93b14bb3946b44a9718afc6f6415cbe0ac5dd5bb237d"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19452"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19452""}, {""id"": ""MetaCyc:RXN-9377"", ""source_sha256"": ""12815cb9af8013f0e6176f07cf63617b0ffd07166249d6997ea0bd3a10151f27"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-9377"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9377""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-086_19e01091cb01	MetaCyc:RXN-19452	RO:0002413	MetaCyc:RXN-19461	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-19452|MetaCyc:RXN-19461	Shared intermediate: MetaCyc:Threonyl-DhbF. This is a chemical handoff, not an assertion of physical channeling or a single linear activation order.	"[{""reference_id"": ""MetaCyc:RXN-19452"", ""source_assertion"": ""The native product slot contains Threonyl-DhbF."", ""source_locator"": ""Reaction[@frameid=\""RXN-19452\""]/right/*[@frameid=\""Threonyl-DhbF\""]""}, {""reference_id"": ""MetaCyc:RXN-19461"", ""source_assertion"": ""The native substrate slot contains Threonyl-DhbF."", ""source_locator"": ""Reaction[@frameid=\""RXN-19461\""]/left/*[@frameid=\""Threonyl-DhbF\""]""}]"	"[{""id"": ""MetaCyc:RXN-19452"", ""source_sha256"": ""d2d9608e4dbf6136419a93b14bb3946b44a9718afc6f6415cbe0ac5dd5bb237d"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19452"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19452""}, {""id"": ""MetaCyc:RXN-19461"", ""source_sha256"": ""909fd360958be5f9e9b590db37d24b0812a2ac127bf2f1c130573c0da3a67ae7"", ""source_version"": ""MetaCyc 22.5; exact original XML retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-19461"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19461""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-087_db443483d06c	MetaCyc:RXN-19461	RO:0002413	MetaCyc:RXN-19462	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:39870587|metanetx.chemical:MNXM743865	Shared intermediate: metanetx.chemical:MNXM743865. This is a chemical handoff, not an assertion of physical channeling or a single linear activation order.	"[{""reference_id"": ""PMID:39870587"", ""source_assertion"": ""The second DhbF condensation domain forms the DHB-Gly-L-Thr carrier-bound unit; the TE domain then mediates trimeric cyclorelease to bacillibactin."", ""source_locator"": ""PDF p.4 Figure 1b and caption""}, {""reference_id"": ""metanetx.chemical:MNXM743865"", ""source_assertion"": ""The selected intermediate is the independently named DHB-glycyl-L-threonyl DhbF reactive class; old arginyl cross-references are not exact mappings."", ""source_locator"": ""Unique MolecularEntity JSON-LD: identifier, name, smiles""}]"	"[{""id"": ""PMID:39870587"", ""source_sha256"": ""b0634407933acfa5a161698520e4eb370a73955908b4af913f5c9cae877af86b"", ""source_version"": ""2025 Osaka official accepted manuscript and complete supplement, 30 PDF pages; page numbers include repository cover; exact original PDF"", ""title"": ""Biosynthetic Characterization of Bacillibactin in Thermophilic Bacillaceae and its Potential for in Vitro Mutational Synthesis"", ""url"": ""https://ir.library.osaka-u.ac.jp/repo/ouka/all/100254/ChemBioChem_cbic.202400836.pdf""}, {""id"": ""metanetx.chemical:MNXM743865"", ""source_sha256"": ""f762cb0962dd4b6802140068b21071ce1433df9a748110526db06b853c2bc6a5"", ""source_version"": ""MNXref production 4.5 per separately retained release page; exact original HTML retrieved 2026-10-11; no versioned bulk dump claimed"", ""title"": ""a 2,3-dihydroxybenzoyl-glycyl-L-threonyl-[DhbF non-ribosomal peptide synthase]"", ""url"": ""https://www.metanetx.org/chem_info/MNXM743865""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-088_fac314b36950	NCBIProtein:BDG45617.1	pathwaymech:activates	NCBIProtein:BDG45614.1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BDG45617.1|PMID:39870587	Activation by phosphopantetheinylation in the KH3-4-derived preparation; DhbB modification was measured directly. The printed coexpression primer mismatch does not prove that an incorrect plasmid was used.	"[{""reference_id"": ""NCBIProtein:BDG45617.1"", ""source_assertion"": ""The original versioned KH3-4 GenPept entry identifies the cluster 4-prime-phosphopantetheinyl transferase and its AP025627.1 coding region."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BDG45617.1\""]/GBSeq_definition; GBSeq_feature-table/GBFeature/GBFeature_quals""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""Methods identify BDG45617 as the KH3-4 PPTase gene and BDG45614/BDG45615 as DhbB/DhbF. The proteins were expressed with tags and/or coexpression; this identifies native gene sources, not fully verified engineered construct sequences."", ""source_locator"": ""PDF p.12, Plasmid construction; pp.12-13, Production and purification""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""Purified PPTase and CoA increase apo-DhbB mass by about 340 Da. The no-PPTase control and coexpression preparation support phosphopantetheinylation. The printed coexpression primer discrepancy limits exact construct reconstruction."", ""source_locator"": ""PDF pp.5-6, PPTase Results and Figure 3; p.14, PPTase assay; p.19, SI Table S1""}]"	"[{""id"": ""NCBIProtein:BDG45617.1"", ""source_sha256"": ""02d17fd6734213be23874dee65922ec69c53cf122c85993ae4ce08cd24c23709"", ""source_version"": ""NCBI original complete seven-entry GenPept XML batch; versioned accession; retrieved 2026-10-11; reference hash covers the whole original response"", ""title"": ""4'-phosphopantetheinyl transferase [Parageobacillus sp. KH3-4]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BDG45611,BDG45612,BDG45613,BDG45614,BDG45615,BDG45616,BDG45617&rettype=gb&retmode=xml""}, {""id"": ""PMID:39870587"", ""source_sha256"": ""b0634407933acfa5a161698520e4eb370a73955908b4af913f5c9cae877af86b"", ""source_version"": ""2025 Osaka official accepted manuscript and complete supplement, 30 PDF pages; page numbers include repository cover; exact original PDF"", ""title"": ""Biosynthetic Characterization of Bacillibactin in Thermophilic Bacillaceae and its Potential for in Vitro Mutational Synthesis"", ""url"": ""https://ir.library.osaka-u.ac.jp/repo/ouka/all/100254/ChemBioChem_cbic.202400836.pdf""}]"	""
pathwaymech:MetaCyc_PWY-5903_bacillibactin-edge-089_8dc466f0b0c8	NCBIProtein:BDG45617.1	pathwaymech:activates	NCBIProtein:BDG45615.1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BDG45617.1|PMID:39870587	PPTase-dependent activation model supported by coexpression and function. Both DhbF carrier-site occupancies were not directly measured; this is weaker evidence than the measured DhbB mass shift.	"[{""reference_id"": ""NCBIProtein:BDG45617.1"", ""source_assertion"": ""The original versioned KH3-4 GenPept entry identifies the cluster 4-prime-phosphopantetheinyl transferase and its AP025627.1 coding region."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BDG45617.1\""]/GBSeq_definition; GBSeq_feature-table/GBFeature/GBFeature_quals""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""Methods identify BDG45617 as the KH3-4 PPTase gene and BDG45614/BDG45615 as DhbB/DhbF. The proteins were expressed with tags and/or coexpression; this identifies native gene sources, not fully verified engineered construct sequences."", ""source_locator"": ""PDF p.12, Plasmid construction; pp.12-13, Production and purification""}, {""reference_id"": ""PMID:39870587"", ""source_assertion"": ""DhbF was coexpressed with PPTase and the resulting preparation was used as holo-DhbF in active NRPS reconstitution. Its large mass excluded direct MALDI modification analysis; full site occupancy was not independently measured."", ""source_locator"": ""PDF pp.5-7, PPTase Results and Figure 3 discussion; pp.12-14, coexpression and reconstitution Methods""}]"	"[{""id"": ""NCBIProtein:BDG45617.1"", ""source_sha256"": ""02d17fd6734213be23874dee65922ec69c53cf122c85993ae4ce08cd24c23709"", ""source_version"": ""NCBI original complete seven-entry GenPept XML batch; versioned accession; retrieved 2026-10-11; reference hash covers the whole original response"", ""title"": ""4'-phosphopantetheinyl transferase [Parageobacillus sp. KH3-4]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BDG45611,BDG45612,BDG45613,BDG45614,BDG45615,BDG45616,BDG45617&rettype=gb&retmode=xml""}, {""id"": ""PMID:39870587"", ""source_sha256"": ""b0634407933acfa5a161698520e4eb370a73955908b4af913f5c9cae877af86b"", ""source_version"": ""2025 Osaka official accepted manuscript and complete supplement, 30 PDF pages; page numbers include repository cover; exact original PDF"", ""title"": ""Biosynthetic Characterization of Bacillibactin in Thermophilic Bacillaceae and its Potential for in Vitro Mutational Synthesis"", ""url"": ""https://ir.library.osaka-u.ac.jp/repo/ouka/all/100254/ChemBioChem_cbic.202400836.pdf""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-001_261d0ceb2ee2	gomodel:RXN-9015	RO:0002234	CHEBI:16240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:RXN-9015 RO:0002234 gomodel:CHEBI_16240_RXN-9015."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/0; endpoint types: /individuals/10/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-002_1d9474aee469	gomodel:3-PROPANAL-DEHYDROGENASE-RXN	RO:0002234	CHEBI:57966	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:3-PROPANAL-DEHYDROGENASE-RXN RO:0002234 gomodel:CHEBI_57966_3-PROPANAL-DEHYDROGENASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/1; endpoint types: /individuals/30/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-003_a9056f4479ce	gomodel:RXN-9015	BFO:0000050	GO:0019483	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:RXN-9015 BFO:0000050 gomodel:YeastPathways_PWY-5760-1/YeastPathways_PWY-5760-1."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/2; endpoint types: /individuals/10/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-004_4ef2b1180a40	gomodel:3-PROPANAL-DEHYDROGENASE-RXN	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:3-PROPANAL-DEHYDROGENASE-RXN RO:0002233 gomodel:CHEBI_57540_3-PROPANAL-DEHYDROGENASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/3; endpoint types: /individuals/30/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-005_5bb847fff715	gomodel:RXN-9015	RO:0002233	CHEBI:45725	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:RXN-9015 RO:0002233 gomodel:CHEBI_45725_RXN-9015."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/4; endpoint types: /individuals/10/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-006_d20691024ef3	gomodel:YeastPathways_PWY-5760-1/6a46ef0600000716	BFO:0000050	GO:0019483	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5760-1/6a46ef0600000716 BFO:0000050 gomodel:YeastPathways_PWY-5760-1/6a46ef0600000730."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/5; endpoint types: /individuals/32/type; /individuals/45/type""}, {""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5760-1/6a46ef0600000716 BFO:0000050 gomodel:YeastPathways_PWY-5760-1/YeastPathways_PWY-5760-1."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/7; endpoint types: /individuals/32/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-007_dbea07536506	gomodel:3-PROPANAL-DEHYDROGENASE-RXN	BFO:0000050	GO:0019483	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:3-PROPANAL-DEHYDROGENASE-RXN BFO:0000050 gomodel:YeastPathways_PWY-5760-1/YeastPathways_PWY-5760-1."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/6; endpoint types: /individuals/30/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-008_08a4248d3aef	gomodel:YeastPathways_PWY-5760-1/6a46ef0600000716	RO:0002233	CHEBI:58374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5760-1/6a46ef0600000716 RO:0002233 gomodel:CHEBI_58374_RXN-9015."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/8; endpoint types: /individuals/32/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-009_7b4e541dea73	SGD:S000004780	pathwaymech:enables	gomodel:3-PROPANAL-DEHYDROGENASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:3-PROPANAL-DEHYDROGENASE-RXN RO:0002333 gomodel:YMR170C-MONOMER_3-PROPANAL-DEHYDROGENASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/9; endpoint types: /individuals/30/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-010_6827aa8fb3fc	gomodel:RXN-9015	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:RXN-9015 RO:0002233 gomodel:CHEBI_15377_RXN-9015."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/10; endpoint types: /individuals/10/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-011_fd88ab845c39	gomodel:RXN-9015	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:RXN-9015 RO:0002233 gomodel:CHEBI_15379_RXN-9015."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/11; endpoint types: /individuals/10/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-012_7338053d1d1e	gomodel:RXN-9015	RO:0002234	CHEBI:58374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:RXN-9015 RO:0002234 gomodel:CHEBI_58374_RXN-9015."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/12; endpoint types: /individuals/10/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-013_ca8f6ca94fe5	gomodel:3-PROPANAL-DEHYDROGENASE-RXN	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:3-PROPANAL-DEHYDROGENASE-RXN RO:0002234 gomodel:CHEBI_57945_3-PROPANAL-DEHYDROGENASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/13; endpoint types: /individuals/30/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-014_97f8ec191f5a	gomodel:YeastPathways_PWY-5760-1/6a46ef0600000716	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5760-1/6a46ef0600000716 BFO:0000066 gomodel:YeastPathways_PWY-5760-1/6a46ef0600000723."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/14; endpoint types: /individuals/32/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-015_9dedff861f82	gomodel:3-PROPANAL-DEHYDROGENASE-RXN	RO:0002233	CHEBI:58374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:3-PROPANAL-DEHYDROGENASE-RXN RO:0002233 gomodel:CHEBI_58374_RXN-9015."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/15; endpoint types: /individuals/30/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-016_9aef06e62135	gomodel:3-PROPANAL-DEHYDROGENASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:3-PROPANAL-DEHYDROGENASE-RXN BFO:0000066 gomodel:reaction_3-PROPANAL-DEHYDROGENASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/16; endpoint types: /individuals/30/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-017_746b94cd4e16	gomodel:YeastPathways_PWY-5760-1/6a46ef0600000716	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5760-1/6a46ef0600000716 RO:0002233 gomodel:YeastPathways_PWY-5760-1/6a46ef0600000717."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/17; endpoint types: /individuals/32/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-018_52d1a18fe097	gomodel:YeastPathways_PWY-5760-1/6a46ef0600000716	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5760-1/6a46ef0600000716 RO:0002233 gomodel:YeastPathways_PWY-5760-1/6a46ef0600000718."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/18; endpoint types: /individuals/32/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-019_1d9bcc7c9dd1	gomodel:3-PROPANAL-DEHYDROGENASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:3-PROPANAL-DEHYDROGENASE-RXN RO:0002233 gomodel:CHEBI_15377_3-PROPANAL-DEHYDROGENASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/19; endpoint types: /individuals/30/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-020_6bc7bee32d79	SGD:S000004779	pathwaymech:enables	gomodel:YeastPathways_PWY-5760-1/6a46ef0600000716	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5760-1/6a46ef0600000716 RO:0002333 gomodel:YeastPathways_PWY-5760-1/6a46ef0600000722."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/20; endpoint types: /individuals/32/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-021_19e550bf010e	gomodel:RXN-9015	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:RXN-9015 BFO:0000066 gomodel:reaction_RXN-9015_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/21; endpoint types: /individuals/10/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-022_79e52dbef50d	gomodel:YeastPathways_PWY-5760-1/6a46ef0600000716	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5760-1/6a46ef0600000716 RO:0002234 gomodel:YeastPathways_PWY-5760-1/6a46ef0600000720."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/22; endpoint types: /individuals/32/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-023_85e343b17ea4	SGD:S000004622	pathwaymech:enables	gomodel:RXN-9015	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:RXN-9015 RO:0002333 gomodel:YMR020W-MONOMER_RXN-9015_controller."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/23; endpoint types: /individuals/10/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-024_64a1fbb6359d	gomodel:YeastPathways_PWY-5760-1/6a46ef0600000716	RO:0002234	CHEBI:57966	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5760-1/6a46ef0600000716 RO:0002234 gomodel:YeastPathways_PWY-5760-1/6a46ef0600000719."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/24; endpoint types: /individuals/32/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_edge-025_c5ee104885f1	gomodel:RXN-9015	RO:0002234	CHEBI:57834	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5760-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_assertion"": ""The model asserts gomodel:RXN-9015 RO:0002234 gomodel:CHEBI_57834_RXN-9015."", ""source_locator"": ""./YeastPathways_PWY-5760-1.json#/facts/25; endpoint types: /individuals/10/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5760-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5760-1.json"", ""title"": ""GO-CAM beta-alanine biosynthesis IV model YeastPathways_PWY-5760-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_location-3b70e1ade62c_b4f10d412fa0	SGD:S000004780	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47771	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11914276)	"[{""reference_id"": ""UniProtKB:P47771"", ""source_assertion"": ""UniProtKB:P47771 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3891/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P47771"", ""source_assertion"": ""UniProtKB:P47771 has the exact SGD cross-reference SGD:S000004780."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3891/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P47771"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47771 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_location-62678b640c37_7e578eff6f9d	SGD:S000004779	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P54114	Physical protein location from reviewed UniProt. ECO:0000250	"[{""reference_id"": ""UniProtKB:P54114"", ""source_assertion"": ""UniProtKB:P54114 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4024/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P54114"", ""source_assertion"": ""UniProtKB:P54114 has the exact SGD cross-reference SGD:S000004779."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4024/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P54114"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P54114 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5760-1_cofactor-5a0213f8d6d7_6c20d1dd7c2f	SGD:S000004622	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P50264	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:12670477) Binds 1 FAD per subunit. UniProt note evidence: ECO:0000269 (PubMed:12670477)	"[{""reference_id"": ""UniProtKB:P50264"", ""source_assertion"": ""UniProtKB:P50264 annotates CHEBI:57692 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3912/comments/0/cofactors/0; /results/3912/comments/0/note""}, {""reference_id"": ""UniProtKB:P50264"", ""source_assertion"": ""UniProtKB:P50264 has the exact SGD cross-reference SGD:S000004622."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3912/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P50264"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P50264 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-001_83e6cf3b201e	RHEA-COMP:9623	pathwaymech:consumes	RHEA:17106	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17106		"[{""reference_id"": ""RHEA:17106"", ""source_assertion"": ""RHEA:17106 assigns RHEA-COMP:9623 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/17106 rh:substrates; http://rdf.rhea-db.org/17105_L rh:contains1 http://rdf.rhea-db.org/Participant_17105_compound_9623; rh:compound http://rdf.rhea-db.org/Compound_9623""}]"	"[{""id"": ""RHEA:17106"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 17106"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-002_1f160ba88e9c	CHEBI:59789	pathwaymech:consumes	RHEA:17106	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17106		"[{""reference_id"": ""RHEA:17106"", ""source_assertion"": ""RHEA:17106 assigns CHEBI:59789 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/17106 rh:substrates; http://rdf.rhea-db.org/17105_L rh:contains1 http://rdf.rhea-db.org/Participant_17105_compound_6127; rh:compound http://rdf.rhea-db.org/Compound_6127""}]"	"[{""id"": ""RHEA:17106"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 17106"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-003_9b2f34990d74	RHEA:17106	pathwaymech:produces	RHEA-COMP:9954	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17106		"[{""reference_id"": ""RHEA:17106"", ""source_assertion"": ""RHEA:17106 assigns RHEA-COMP:9954 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/17106 rh:products; http://rdf.rhea-db.org/17105_R rh:contains1 http://rdf.rhea-db.org/Participant_17105_compound_9954; rh:compound http://rdf.rhea-db.org/Compound_9954""}]"	"[{""id"": ""RHEA:17106"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 17106"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-004_07d70512a0e1	RHEA:17106	pathwaymech:produces	CHEBI:57856	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17106		"[{""reference_id"": ""RHEA:17106"", ""source_assertion"": ""RHEA:17106 assigns CHEBI:57856 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/17106 rh:products; http://rdf.rhea-db.org/17105_R rh:contains1 http://rdf.rhea-db.org/Participant_17105_compound_4281; rh:compound http://rdf.rhea-db.org/Compound_4281""}]"	"[{""id"": ""RHEA:17106"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 17106"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-005_25d5f9d54b2d	RHEA-COMP:9954	pathwaymech:consumes	MetaCyc:RXN-11474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11474|RHEA:17106	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11474"", ""source_assertion"": ""Native RXN-11474 has Malonyl-acp-methyl-ester on left, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11474']/left/*[@frameid='Malonyl-acp-methyl-ester']; sibling coefficient (absent means 1); reaction-direction""}, {""reference_id"": ""RHEA:17106"", ""source_assertion"": ""Independent Rhea whole-carrier identity used for the native ACP state: RHEA-COMP:9954; reactive-part ChEBI is not the whole carrier."", ""source_locator"": ""http://rdf.rhea-db.org/Compound_9954 rh:name; rh:reactivePart""}]"	"[{""id"": ""MetaCyc:RXN-11474"", ""source_sha256"": ""40d8fba7b90960555167184303a1263ffc6634ea3b76aed61c6f486e6549e952"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a malonyl-[acp] methyl ester + a malonyl-[acp] + H+ -> a 3-oxoglutaryl-[acp] methyl ester + CO2 + acyl-carrier protein"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11474""}, {""id"": ""RHEA:17106"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 17106"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-006_cd2884188f87	RHEA-COMP:9623	pathwaymech:consumes	MetaCyc:RXN-11474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11474|RHEA:17106	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11474"", ""source_assertion"": ""Native RXN-11474 has MALONYL-ACP on left, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11474']/left/*[@frameid='MALONYL-ACP']; sibling coefficient (absent means 1); reaction-direction""}, {""reference_id"": ""RHEA:17106"", ""source_assertion"": ""Independent Rhea whole-carrier identity used for the native ACP state: RHEA-COMP:9623; reactive-part ChEBI is not the whole carrier."", ""source_locator"": ""http://rdf.rhea-db.org/Compound_9623 rh:name; rh:reactivePart""}]"	"[{""id"": ""MetaCyc:RXN-11474"", ""source_sha256"": ""40d8fba7b90960555167184303a1263ffc6634ea3b76aed61c6f486e6549e952"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a malonyl-[acp] methyl ester + a malonyl-[acp] + H+ -> a 3-oxoglutaryl-[acp] methyl ester + CO2 + acyl-carrier protein"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11474""}, {""id"": ""RHEA:17106"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 17106"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-007_7876022d2d1e	CHEBI:15378	pathwaymech:consumes	MetaCyc:RXN-11474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11474	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11474"", ""source_assertion"": ""Native RXN-11474 has PROTON on left, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11474']/left/*[@frameid='PROTON']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11474"", ""source_sha256"": ""40d8fba7b90960555167184303a1263ffc6634ea3b76aed61c6f486e6549e952"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a malonyl-[acp] methyl ester + a malonyl-[acp] + H+ -> a 3-oxoglutaryl-[acp] methyl ester + CO2 + acyl-carrier protein"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11474""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-008_1cd3a82064a2	MetaCyc:RXN-11474	pathwaymech:produces	MetaCyc:3-Ketoglutaryl-ACP-methyl-ester	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11474	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11474"", ""source_assertion"": ""Native RXN-11474 has 3-Ketoglutaryl-ACP-methyl-ester on right, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11474']/right/*[@frameid='3-Ketoglutaryl-ACP-methyl-ester']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11474"", ""source_sha256"": ""40d8fba7b90960555167184303a1263ffc6634ea3b76aed61c6f486e6549e952"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a malonyl-[acp] methyl ester + a malonyl-[acp] + H+ -> a 3-oxoglutaryl-[acp] methyl ester + CO2 + acyl-carrier protein"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11474""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-009_28714ae0252a	MetaCyc:RXN-11474	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11474	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11474"", ""source_assertion"": ""Native RXN-11474 has CARBON-DIOXIDE on right, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11474']/right/*[@frameid='CARBON-DIOXIDE']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11474"", ""source_sha256"": ""40d8fba7b90960555167184303a1263ffc6634ea3b76aed61c6f486e6549e952"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a malonyl-[acp] methyl ester + a malonyl-[acp] + H+ -> a 3-oxoglutaryl-[acp] methyl ester + CO2 + acyl-carrier protein"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11474""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-010_e3e0c32475ac	MetaCyc:RXN-11474	pathwaymech:produces	RHEA-COMP:9685	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11474|RHEA:42289	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11474"", ""source_assertion"": ""Native RXN-11474 has ACP on right, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11474']/right/*[@frameid='ACP']; sibling coefficient (absent means 1); reaction-direction""}, {""reference_id"": ""RHEA:42289"", ""source_assertion"": ""Independent Rhea whole-carrier identity used for the native ACP state: RHEA-COMP:9685; reactive-part ChEBI is not the whole carrier."", ""source_locator"": ""http://rdf.rhea-db.org/Compound_9685 rh:name; rh:reactivePart""}]"	"[{""id"": ""MetaCyc:RXN-11474"", ""source_sha256"": ""40d8fba7b90960555167184303a1263ffc6634ea3b76aed61c6f486e6549e952"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a malonyl-[acp] methyl ester + a malonyl-[acp] + H+ -> a 3-oxoglutaryl-[acp] methyl ester + CO2 + acyl-carrier protein"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11474""}, {""id"": ""RHEA:42289"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42289"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-011_68f8ad15c73b	MetaCyc:RXN-11476	pathwaymech:produces	MetaCyc:3-Hydroxyglutaryl-ACP-methyl-ester	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11476	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11476"", ""source_assertion"": ""Native RXN-11476 has 3-Hydroxyglutaryl-ACP-methyl-ester on left, coefficient 1; physiological direction PHYSIOL-RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11476']/left/*[@frameid='3-Hydroxyglutaryl-ACP-methyl-ester']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11476"", ""source_sha256"": ""59600a069a2df429da311f8da1b0bb9ad8a928bb9593af86b4b880e619c00436"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxyglutaryl-[acp] methyl ester + NADP+ <- a 3-oxoglutaryl-[acp] methyl ester + NADPH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11476""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-012_7909adea6a69	MetaCyc:RXN-11476	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11476	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11476"", ""source_assertion"": ""Native RXN-11476 has NADP on left, coefficient 1; physiological direction PHYSIOL-RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11476']/left/*[@frameid='NADP']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11476"", ""source_sha256"": ""59600a069a2df429da311f8da1b0bb9ad8a928bb9593af86b4b880e619c00436"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxyglutaryl-[acp] methyl ester + NADP+ <- a 3-oxoglutaryl-[acp] methyl ester + NADPH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11476""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-013_8e6abdefa73f	MetaCyc:3-Ketoglutaryl-ACP-methyl-ester	pathwaymech:consumes	MetaCyc:RXN-11476	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11476	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11476"", ""source_assertion"": ""Native RXN-11476 has 3-Ketoglutaryl-ACP-methyl-ester on right, coefficient 1; physiological direction PHYSIOL-RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11476']/right/*[@frameid='3-Ketoglutaryl-ACP-methyl-ester']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11476"", ""source_sha256"": ""59600a069a2df429da311f8da1b0bb9ad8a928bb9593af86b4b880e619c00436"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxyglutaryl-[acp] methyl ester + NADP+ <- a 3-oxoglutaryl-[acp] methyl ester + NADPH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11476""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-014_12f39292cab8	CHEBI:57783	pathwaymech:consumes	MetaCyc:RXN-11476	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11476	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11476"", ""source_assertion"": ""Native RXN-11476 has NADPH on right, coefficient 1; physiological direction PHYSIOL-RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11476']/right/*[@frameid='NADPH']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11476"", ""source_sha256"": ""59600a069a2df429da311f8da1b0bb9ad8a928bb9593af86b4b880e619c00436"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxyglutaryl-[acp] methyl ester + NADP+ <- a 3-oxoglutaryl-[acp] methyl ester + NADPH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11476""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-015_772abf4f0c1a	CHEBI:15378	pathwaymech:consumes	MetaCyc:RXN-11476	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11476	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11476"", ""source_assertion"": ""Native RXN-11476 has PROTON on right, coefficient 1; physiological direction PHYSIOL-RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11476']/right/*[@frameid='PROTON']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11476"", ""source_sha256"": ""59600a069a2df429da311f8da1b0bb9ad8a928bb9593af86b4b880e619c00436"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxyglutaryl-[acp] methyl ester + NADP+ <- a 3-oxoglutaryl-[acp] methyl ester + NADPH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11476""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-016_be7e4a68bd5b	MetaCyc:3-Hydroxyglutaryl-ACP-methyl-ester	pathwaymech:consumes	MetaCyc:RXN-11477	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11477	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11477"", ""source_assertion"": ""Native RXN-11477 has 3-Hydroxyglutaryl-ACP-methyl-ester on left, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11477']/left/*[@frameid='3-Hydroxyglutaryl-ACP-methyl-ester']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11477"", ""source_sha256"": ""8021d303f182bb7be60e1f94d8855c02a1444eb9595c303c4738416b40a8b731"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxyglutaryl-[acp] methyl ester -> an enoylglutaryl-[acp] methyl ester + H2O"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11477""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-017_60a1ae40c5da	MetaCyc:RXN-11477	pathwaymech:produces	MetaCyc:Enoylglutaryl-ACP-methyl-esters	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11477	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11477"", ""source_assertion"": ""Native RXN-11477 has Enoylglutaryl-ACP-methyl-esters on right, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11477']/right/*[@frameid='Enoylglutaryl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11477"", ""source_sha256"": ""8021d303f182bb7be60e1f94d8855c02a1444eb9595c303c4738416b40a8b731"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxyglutaryl-[acp] methyl ester -> an enoylglutaryl-[acp] methyl ester + H2O"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11477""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-018_4d82ab9e083c	MetaCyc:RXN-11477	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11477	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11477"", ""source_assertion"": ""Native RXN-11477 has WATER on right, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11477']/right/*[@frameid='WATER']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11477"", ""source_sha256"": ""8021d303f182bb7be60e1f94d8855c02a1444eb9595c303c4738416b40a8b731"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxyglutaryl-[acp] methyl ester -> an enoylglutaryl-[acp] methyl ester + H2O"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11477""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-019_9aaca0244aee	MetaCyc:RXN-11478	pathwaymech:produces	MetaCyc:Glutaryl-ACP-methyl-esters	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11478	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11478"", ""source_assertion"": ""Native RXN-11478 has Glutaryl-ACP-methyl-esters on left, coefficient 1; physiological direction RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11478']/left/*[@frameid='Glutaryl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11478"", ""source_sha256"": ""002a05ab29160873d0b3e9960baf4759d68d30bcaea7bcc213abdd5503003968"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a glutaryl-[acp] methyl ester + NAD+ <- an enoylglutaryl-[acp] methyl ester + NADH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11478""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-020_13151b869acc	MetaCyc:RXN-11478	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11478	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11478"", ""source_assertion"": ""Native RXN-11478 has NAD on left, coefficient 1; physiological direction RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11478']/left/*[@frameid='NAD']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11478"", ""source_sha256"": ""002a05ab29160873d0b3e9960baf4759d68d30bcaea7bcc213abdd5503003968"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a glutaryl-[acp] methyl ester + NAD+ <- an enoylglutaryl-[acp] methyl ester + NADH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11478""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-021_cb4a6d3f825a	MetaCyc:Enoylglutaryl-ACP-methyl-esters	pathwaymech:consumes	MetaCyc:RXN-11478	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11478	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11478"", ""source_assertion"": ""Native RXN-11478 has Enoylglutaryl-ACP-methyl-esters on right, coefficient 1; physiological direction RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11478']/right/*[@frameid='Enoylglutaryl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11478"", ""source_sha256"": ""002a05ab29160873d0b3e9960baf4759d68d30bcaea7bcc213abdd5503003968"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a glutaryl-[acp] methyl ester + NAD+ <- an enoylglutaryl-[acp] methyl ester + NADH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11478""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-022_11f6a2eab484	CHEBI:57945	pathwaymech:consumes	MetaCyc:RXN-11478	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11478	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11478"", ""source_assertion"": ""Native RXN-11478 has NADH on right, coefficient 1; physiological direction RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11478']/right/*[@frameid='NADH']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11478"", ""source_sha256"": ""002a05ab29160873d0b3e9960baf4759d68d30bcaea7bcc213abdd5503003968"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a glutaryl-[acp] methyl ester + NAD+ <- an enoylglutaryl-[acp] methyl ester + NADH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11478""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-023_8d861de88c1a	CHEBI:15378	pathwaymech:consumes	MetaCyc:RXN-11478	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11478	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11478"", ""source_assertion"": ""Native RXN-11478 has PROTON on right, coefficient 1; physiological direction RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11478']/right/*[@frameid='PROTON']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11478"", ""source_sha256"": ""002a05ab29160873d0b3e9960baf4759d68d30bcaea7bcc213abdd5503003968"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a glutaryl-[acp] methyl ester + NAD+ <- an enoylglutaryl-[acp] methyl ester + NADH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11478""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-024_64c1ba82d23f	MetaCyc:Glutaryl-ACP-methyl-esters	pathwaymech:consumes	MetaCyc:RXN-11479	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11479	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11479"", ""source_assertion"": ""Native RXN-11479 has Glutaryl-ACP-methyl-esters on left, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11479']/left/*[@frameid='Glutaryl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11479"", ""source_sha256"": ""46432517a765cc21bde5e9d697a0a1e8997e7d233268c80335aac91f09f3de23"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a glutaryl-[acp] methyl ester + a malonyl-[acp] + H+ -> a 3-oxopimeloyl-[acp] methyl ester + CO2 + acyl-carrier protein"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11479""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-025_b57e453ca59f	RHEA-COMP:9623	pathwaymech:consumes	MetaCyc:RXN-11479	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11479|RHEA:17106	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11479"", ""source_assertion"": ""Native RXN-11479 has MALONYL-ACP on left, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11479']/left/*[@frameid='MALONYL-ACP']; sibling coefficient (absent means 1); reaction-direction""}, {""reference_id"": ""RHEA:17106"", ""source_assertion"": ""Independent Rhea whole-carrier identity used for the native ACP state: RHEA-COMP:9623; reactive-part ChEBI is not the whole carrier."", ""source_locator"": ""http://rdf.rhea-db.org/Compound_9623 rh:name; rh:reactivePart""}]"	"[{""id"": ""MetaCyc:RXN-11479"", ""source_sha256"": ""46432517a765cc21bde5e9d697a0a1e8997e7d233268c80335aac91f09f3de23"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a glutaryl-[acp] methyl ester + a malonyl-[acp] + H+ -> a 3-oxopimeloyl-[acp] methyl ester + CO2 + acyl-carrier protein"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11479""}, {""id"": ""RHEA:17106"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 17106"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-026_7f3eeaae0282	CHEBI:15378	pathwaymech:consumes	MetaCyc:RXN-11479	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11479	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11479"", ""source_assertion"": ""Native RXN-11479 has PROTON on left, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11479']/left/*[@frameid='PROTON']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11479"", ""source_sha256"": ""46432517a765cc21bde5e9d697a0a1e8997e7d233268c80335aac91f09f3de23"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a glutaryl-[acp] methyl ester + a malonyl-[acp] + H+ -> a 3-oxopimeloyl-[acp] methyl ester + CO2 + acyl-carrier protein"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11479""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-027_e21c12c8eb93	MetaCyc:RXN-11479	pathwaymech:produces	MetaCyc:3-Ketopimeloyl-ACP-methyl-esters	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11479	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11479"", ""source_assertion"": ""Native RXN-11479 has 3-Ketopimeloyl-ACP-methyl-esters on right, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11479']/right/*[@frameid='3-Ketopimeloyl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11479"", ""source_sha256"": ""46432517a765cc21bde5e9d697a0a1e8997e7d233268c80335aac91f09f3de23"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a glutaryl-[acp] methyl ester + a malonyl-[acp] + H+ -> a 3-oxopimeloyl-[acp] methyl ester + CO2 + acyl-carrier protein"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11479""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-028_2e7a801fc06a	MetaCyc:RXN-11479	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11479	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11479"", ""source_assertion"": ""Native RXN-11479 has CARBON-DIOXIDE on right, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11479']/right/*[@frameid='CARBON-DIOXIDE']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11479"", ""source_sha256"": ""46432517a765cc21bde5e9d697a0a1e8997e7d233268c80335aac91f09f3de23"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a glutaryl-[acp] methyl ester + a malonyl-[acp] + H+ -> a 3-oxopimeloyl-[acp] methyl ester + CO2 + acyl-carrier protein"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11479""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-029_35a6e9b54066	MetaCyc:RXN-11479	pathwaymech:produces	RHEA-COMP:9685	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11479|RHEA:42289	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11479"", ""source_assertion"": ""Native RXN-11479 has ACP on right, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11479']/right/*[@frameid='ACP']; sibling coefficient (absent means 1); reaction-direction""}, {""reference_id"": ""RHEA:42289"", ""source_assertion"": ""Independent Rhea whole-carrier identity used for the native ACP state: RHEA-COMP:9685; reactive-part ChEBI is not the whole carrier."", ""source_locator"": ""http://rdf.rhea-db.org/Compound_9685 rh:name; rh:reactivePart""}]"	"[{""id"": ""MetaCyc:RXN-11479"", ""source_sha256"": ""46432517a765cc21bde5e9d697a0a1e8997e7d233268c80335aac91f09f3de23"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a glutaryl-[acp] methyl ester + a malonyl-[acp] + H+ -> a 3-oxopimeloyl-[acp] methyl ester + CO2 + acyl-carrier protein"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11479""}, {""id"": ""RHEA:42289"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42289"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-030_7b95b5214c76	MetaCyc:RXN-11480	pathwaymech:produces	MetaCyc:3-hydroxypimeloyl-ACP-methyl-esters	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11480	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11480"", ""source_assertion"": ""Native RXN-11480 has 3-hydroxypimeloyl-ACP-methyl-esters on left, coefficient 1; physiological direction PHYSIOL-RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11480']/left/*[@frameid='3-hydroxypimeloyl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11480"", ""source_sha256"": ""47717a29c484666a17446e09815017beffb101577e34d0ec39ba666ed54fae89"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxypimeloyl-[acp] methyl ester + NADP+ <- a 3-oxopimeloyl-[acp] methyl ester + NADPH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11480""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-031_1be588901606	MetaCyc:RXN-11480	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11480	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11480"", ""source_assertion"": ""Native RXN-11480 has NADP on left, coefficient 1; physiological direction PHYSIOL-RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11480']/left/*[@frameid='NADP']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11480"", ""source_sha256"": ""47717a29c484666a17446e09815017beffb101577e34d0ec39ba666ed54fae89"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxypimeloyl-[acp] methyl ester + NADP+ <- a 3-oxopimeloyl-[acp] methyl ester + NADPH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11480""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-032_17146d4d19c6	MetaCyc:3-Ketopimeloyl-ACP-methyl-esters	pathwaymech:consumes	MetaCyc:RXN-11480	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11480	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11480"", ""source_assertion"": ""Native RXN-11480 has 3-Ketopimeloyl-ACP-methyl-esters on right, coefficient 1; physiological direction PHYSIOL-RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11480']/right/*[@frameid='3-Ketopimeloyl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11480"", ""source_sha256"": ""47717a29c484666a17446e09815017beffb101577e34d0ec39ba666ed54fae89"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxypimeloyl-[acp] methyl ester + NADP+ <- a 3-oxopimeloyl-[acp] methyl ester + NADPH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11480""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-033_db5276c02524	CHEBI:57783	pathwaymech:consumes	MetaCyc:RXN-11480	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11480	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11480"", ""source_assertion"": ""Native RXN-11480 has NADPH on right, coefficient 1; physiological direction PHYSIOL-RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11480']/right/*[@frameid='NADPH']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11480"", ""source_sha256"": ""47717a29c484666a17446e09815017beffb101577e34d0ec39ba666ed54fae89"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxypimeloyl-[acp] methyl ester + NADP+ <- a 3-oxopimeloyl-[acp] methyl ester + NADPH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11480""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-034_e1c7404b7267	CHEBI:15378	pathwaymech:consumes	MetaCyc:RXN-11480	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11480	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11480"", ""source_assertion"": ""Native RXN-11480 has PROTON on right, coefficient 1; physiological direction PHYSIOL-RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11480']/right/*[@frameid='PROTON']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11480"", ""source_sha256"": ""47717a29c484666a17446e09815017beffb101577e34d0ec39ba666ed54fae89"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxypimeloyl-[acp] methyl ester + NADP+ <- a 3-oxopimeloyl-[acp] methyl ester + NADPH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11480""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-035_386dd88da41a	MetaCyc:3-hydroxypimeloyl-ACP-methyl-esters	pathwaymech:consumes	MetaCyc:RXN-11481	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11481	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11481"", ""source_assertion"": ""Native RXN-11481 has 3-hydroxypimeloyl-ACP-methyl-esters on left, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11481']/left/*[@frameid='3-hydroxypimeloyl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11481"", ""source_sha256"": ""fec1c07b64a99225356a74d0ee7f83bc2d6d454f3b336c269bc1153474539dc3"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxypimeloyl-[acp] methyl ester -> an enoylpimeloyl-[acp] methyl ester + H2O"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11481""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-036_7105836f065e	MetaCyc:RXN-11481	pathwaymech:produces	MetaCyc:Enoylpimeloyl-ACP-methyl-esters	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11481	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11481"", ""source_assertion"": ""Native RXN-11481 has Enoylpimeloyl-ACP-methyl-esters on right, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11481']/right/*[@frameid='Enoylpimeloyl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11481"", ""source_sha256"": ""fec1c07b64a99225356a74d0ee7f83bc2d6d454f3b336c269bc1153474539dc3"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxypimeloyl-[acp] methyl ester -> an enoylpimeloyl-[acp] methyl ester + H2O"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11481""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-037_463c1a754e3a	MetaCyc:RXN-11481	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11481	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11481"", ""source_assertion"": ""Native RXN-11481 has WATER on right, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11481']/right/*[@frameid='WATER']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11481"", ""source_sha256"": ""fec1c07b64a99225356a74d0ee7f83bc2d6d454f3b336c269bc1153474539dc3"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxypimeloyl-[acp] methyl ester -> an enoylpimeloyl-[acp] methyl ester + H2O"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11481""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-038_10eb16cb7c36	MetaCyc:RXN-11482	pathwaymech:produces	RHEA-COMP:10186	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11482|RHEA:42701	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11482"", ""source_assertion"": ""Native RXN-11482 has Pimeloyl-ACP-methyl-esters on left, coefficient 1; physiological direction RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11482']/left/*[@frameid='Pimeloyl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}, {""reference_id"": ""RHEA:42701"", ""source_assertion"": ""Independent Rhea whole-carrier identity used for the native ACP state: RHEA-COMP:10186; reactive-part ChEBI is not the whole carrier."", ""source_locator"": ""http://rdf.rhea-db.org/Compound_10186 rh:name; rh:reactivePart""}]"	"[{""id"": ""MetaCyc:RXN-11482"", ""source_sha256"": ""994ceb2b8f748de9ec78cbf6f8bd99254b3b390fc2b4ea3578de3c0d78508828"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a pimeloyl-[acp] methyl ester + NAD+ <- an enoylpimeloyl-[acp] methyl ester + NADH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11482""}, {""id"": ""RHEA:42701"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42701"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-039_7649d2db3b5c	MetaCyc:RXN-11482	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11482	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11482"", ""source_assertion"": ""Native RXN-11482 has NAD on left, coefficient 1; physiological direction RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11482']/left/*[@frameid='NAD']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11482"", ""source_sha256"": ""994ceb2b8f748de9ec78cbf6f8bd99254b3b390fc2b4ea3578de3c0d78508828"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a pimeloyl-[acp] methyl ester + NAD+ <- an enoylpimeloyl-[acp] methyl ester + NADH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11482""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-040_d844c5257ffb	MetaCyc:Enoylpimeloyl-ACP-methyl-esters	pathwaymech:consumes	MetaCyc:RXN-11482	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11482	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11482"", ""source_assertion"": ""Native RXN-11482 has Enoylpimeloyl-ACP-methyl-esters on right, coefficient 1; physiological direction RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11482']/right/*[@frameid='Enoylpimeloyl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11482"", ""source_sha256"": ""994ceb2b8f748de9ec78cbf6f8bd99254b3b390fc2b4ea3578de3c0d78508828"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a pimeloyl-[acp] methyl ester + NAD+ <- an enoylpimeloyl-[acp] methyl ester + NADH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11482""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-041_106e8cb04b1e	CHEBI:57945	pathwaymech:consumes	MetaCyc:RXN-11482	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11482	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11482"", ""source_assertion"": ""Native RXN-11482 has NADH on right, coefficient 1; physiological direction RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11482']/right/*[@frameid='NADH']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11482"", ""source_sha256"": ""994ceb2b8f748de9ec78cbf6f8bd99254b3b390fc2b4ea3578de3c0d78508828"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a pimeloyl-[acp] methyl ester + NAD+ <- an enoylpimeloyl-[acp] methyl ester + NADH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11482""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-042_0d34d73b612e	CHEBI:15378	pathwaymech:consumes	MetaCyc:RXN-11482	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11482	Native reaction retained because no exact specific Rhea reaction was verified. Formal protonation of free NAD(P)(H), water, CO2 and hydron follows active ChEBI identities; native ACP classes lack empirical formulas.	"[{""reference_id"": ""MetaCyc:RXN-11482"", ""source_assertion"": ""Native RXN-11482 has PROTON on right, coefficient 1; physiological direction RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11482']/right/*[@frameid='PROTON']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-11482"", ""source_sha256"": ""994ceb2b8f748de9ec78cbf6f8bd99254b3b390fc2b4ea3578de3c0d78508828"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a pimeloyl-[acp] methyl ester + NAD+ <- an enoylpimeloyl-[acp] methyl ester + NADH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11482""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-043_080a294a2c0c	RHEA-COMP:10186	pathwaymech:consumes	RHEA:42701	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42701		"[{""reference_id"": ""RHEA:42701"", ""source_assertion"": ""RHEA:42701 assigns RHEA-COMP:10186 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/42701 rh:substrates; http://rdf.rhea-db.org/42700_L rh:contains1 http://rdf.rhea-db.org/Participant_42700_compound_10186; rh:compound http://rdf.rhea-db.org/Compound_10186""}]"	"[{""id"": ""RHEA:42701"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42701"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-044_f56ca1c4b13f	CHEBI:15377	pathwaymech:consumes	RHEA:42701	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42701		"[{""reference_id"": ""RHEA:42701"", ""source_assertion"": ""RHEA:42701 assigns CHEBI:15377 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/42701 rh:substrates; http://rdf.rhea-db.org/42700_L rh:contains1 http://rdf.rhea-db.org/Participant_42700_compound_1283; rh:compound http://rdf.rhea-db.org/Compound_1283""}]"	"[{""id"": ""RHEA:42701"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42701"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-045_1690a25df703	RHEA:42701	pathwaymech:produces	RHEA-COMP:9955	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42701		"[{""reference_id"": ""RHEA:42701"", ""source_assertion"": ""RHEA:42701 assigns RHEA-COMP:9955 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/42701 rh:products; http://rdf.rhea-db.org/42700_R rh:contains1 http://rdf.rhea-db.org/Participant_42700_compound_9955; rh:compound http://rdf.rhea-db.org/Compound_9955""}]"	"[{""id"": ""RHEA:42701"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42701"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-046_30d58fff5477	RHEA:42701	pathwaymech:produces	CHEBI:17790	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42701		"[{""reference_id"": ""RHEA:42701"", ""source_assertion"": ""RHEA:42701 assigns CHEBI:17790 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/42701 rh:products; http://rdf.rhea-db.org/42700_R rh:contains1 http://rdf.rhea-db.org/Participant_42700_compound_3528; rh:compound http://rdf.rhea-db.org/Compound_3528""}]"	"[{""id"": ""RHEA:42701"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42701"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-047_e553ae340e20	RHEA:42701	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42701		"[{""reference_id"": ""RHEA:42701"", ""source_assertion"": ""RHEA:42701 assigns CHEBI:15378 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/42701 rh:products; http://rdf.rhea-db.org/42700_R rh:contains1 http://rdf.rhea-db.org/Participant_42700_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249""}]"	"[{""id"": ""RHEA:42701"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42701"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-048_694045d6d864	RHEA-COMP:9955	pathwaymech:consumes	RHEA:42289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42289		"[{""reference_id"": ""RHEA:42289"", ""source_assertion"": ""RHEA:42289 assigns RHEA-COMP:9955 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/42289 rh:substrates; http://rdf.rhea-db.org/42288_L rh:contains1 http://rdf.rhea-db.org/Participant_42288_compound_9955; rh:compound http://rdf.rhea-db.org/Compound_9955""}]"	"[{""id"": ""RHEA:42289"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42289"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-049_a30167112e4a	CHEBI:57972	pathwaymech:consumes	RHEA:42289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42289		"[{""reference_id"": ""RHEA:42289"", ""source_assertion"": ""RHEA:42289 assigns CHEBI:57972 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/42289 rh:substrates; http://rdf.rhea-db.org/42288_L rh:contains1 http://rdf.rhea-db.org/Participant_42288_compound_3361; rh:compound http://rdf.rhea-db.org/Compound_3361""}]"	"[{""id"": ""RHEA:42289"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42289"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-050_c591d8d54366	CHEBI:15378	pathwaymech:consumes	RHEA:42289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42289		"[{""reference_id"": ""RHEA:42289"", ""source_assertion"": ""RHEA:42289 assigns CHEBI:15378 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/42289 rh:substrates; http://rdf.rhea-db.org/42288_L rh:contains1 http://rdf.rhea-db.org/Participant_42288_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249""}]"	"[{""id"": ""RHEA:42289"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42289"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-051_604ff7980dd9	RHEA:42289	pathwaymech:produces	CHEBI:149468	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42289		"[{""reference_id"": ""RHEA:42289"", ""source_assertion"": ""RHEA:42289 assigns CHEBI:149468 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/42289 rh:products; http://rdf.rhea-db.org/42288_R rh:contains1 http://rdf.rhea-db.org/Participant_42288_compound_16402; rh:compound http://rdf.rhea-db.org/Compound_16402""}]"	"[{""id"": ""RHEA:42289"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42289"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-052_4cfc99bd8db2	RHEA:42289	pathwaymech:produces	RHEA-COMP:9685	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42289		"[{""reference_id"": ""RHEA:42289"", ""source_assertion"": ""RHEA:42289 assigns RHEA-COMP:9685 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/42289 rh:products; http://rdf.rhea-db.org/42288_R rh:contains1 http://rdf.rhea-db.org/Participant_42288_compound_9685; rh:compound http://rdf.rhea-db.org/Compound_9685""}]"	"[{""id"": ""RHEA:42289"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42289"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-053_12d3155a14a6	RHEA:42289	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42289		"[{""reference_id"": ""RHEA:42289"", ""source_assertion"": ""RHEA:42289 assigns CHEBI:16526 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/42289 rh:products; http://rdf.rhea-db.org/42288_R rh:contains1 http://rdf.rhea-db.org/Participant_42288_compound_4391; rh:compound http://rdf.rhea-db.org/Compound_4391""}]"	"[{""id"": ""RHEA:42289"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42289"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-054_4366e3beb5d7	CHEBI:149468	pathwaymech:consumes	RHEA:16862	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16862		"[{""reference_id"": ""RHEA:16862"", ""source_assertion"": ""RHEA:16862 assigns CHEBI:149468 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/16862 rh:substrates; http://rdf.rhea-db.org/16861_L rh:contains1 http://rdf.rhea-db.org/Participant_16861_compound_16402; rh:compound http://rdf.rhea-db.org/Compound_16402""}]"	"[{""id"": ""RHEA:16862"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 16862"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-055_35b58fec5024	CHEBI:59789	pathwaymech:consumes	RHEA:16862	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16862		"[{""reference_id"": ""RHEA:16862"", ""source_assertion"": ""RHEA:16862 assigns CHEBI:59789 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/16862 rh:substrates; http://rdf.rhea-db.org/16861_L rh:contains1 http://rdf.rhea-db.org/Participant_16861_compound_6127; rh:compound http://rdf.rhea-db.org/Compound_6127""}]"	"[{""id"": ""RHEA:16862"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 16862"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-056_607fe1284c24	RHEA:16862	pathwaymech:produces	CHEBI:16490	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16862		"[{""reference_id"": ""RHEA:16862"", ""source_assertion"": ""RHEA:16862 assigns CHEBI:16490 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/16862 rh:products; http://rdf.rhea-db.org/16861_R rh:contains1 http://rdf.rhea-db.org/Participant_16861_compound_5784; rh:compound http://rdf.rhea-db.org/Compound_5784""}]"	"[{""id"": ""RHEA:16862"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 16862"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-057_4f02aa2b7f86	RHEA:16862	pathwaymech:produces	CHEBI:149469	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16862		"[{""reference_id"": ""RHEA:16862"", ""source_assertion"": ""RHEA:16862 assigns CHEBI:149469 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/16862 rh:products; http://rdf.rhea-db.org/16861_R rh:contains1 http://rdf.rhea-db.org/Participant_16861_compound_16403; rh:compound http://rdf.rhea-db.org/Compound_16403""}]"	"[{""id"": ""RHEA:16862"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 16862"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-058_39e76bc2fc7a	CHEBI:149469	pathwaymech:consumes	RHEA:15806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15806		"[{""reference_id"": ""RHEA:15806"", ""source_assertion"": ""RHEA:15806 assigns CHEBI:149469 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/15806 rh:substrates; http://rdf.rhea-db.org/15805_L rh:contains1 http://rdf.rhea-db.org/Participant_15805_compound_16403; rh:compound http://rdf.rhea-db.org/Compound_16403""}]"	"[{""id"": ""RHEA:15806"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 15806"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-059_6e505cb3b7f7	CHEBI:16526	pathwaymech:consumes	RHEA:15806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15806		"[{""reference_id"": ""RHEA:15806"", ""source_assertion"": ""RHEA:15806 assigns CHEBI:16526 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/15806 rh:substrates; http://rdf.rhea-db.org/15805_L rh:contains1 http://rdf.rhea-db.org/Participant_15805_compound_4391; rh:compound http://rdf.rhea-db.org/Compound_4391""}]"	"[{""id"": ""RHEA:15806"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 15806"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-060_fda2ba46a561	CHEBI:30616	pathwaymech:consumes	RHEA:15806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15806		"[{""reference_id"": ""RHEA:15806"", ""source_assertion"": ""RHEA:15806 assigns CHEBI:30616 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/15806 rh:substrates; http://rdf.rhea-db.org/15805_L rh:contains1 http://rdf.rhea-db.org/Participant_15805_compound_6372; rh:compound http://rdf.rhea-db.org/Compound_6372""}]"	"[{""id"": ""RHEA:15806"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 15806"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-061_bbca7bc7c5c9	RHEA:15806	pathwaymech:produces	CHEBI:149473	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15806		"[{""reference_id"": ""RHEA:15806"", ""source_assertion"": ""RHEA:15806 assigns CHEBI:149473 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/15806 rh:products; http://rdf.rhea-db.org/15805_R rh:contains1 http://rdf.rhea-db.org/Participant_15805_compound_16404; rh:compound http://rdf.rhea-db.org/Compound_16404""}]"	"[{""id"": ""RHEA:15806"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 15806"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-062_6997cc05aabb	RHEA:15806	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15806		"[{""reference_id"": ""RHEA:15806"", ""source_assertion"": ""RHEA:15806 assigns CHEBI:456216 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/15806 rh:products; http://rdf.rhea-db.org/15805_R rh:contains1 http://rdf.rhea-db.org/Participant_15805_compound_2710; rh:compound http://rdf.rhea-db.org/Compound_2710""}]"	"[{""id"": ""RHEA:15806"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 15806"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-063_2f34cd695fee	RHEA:15806	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15806		"[{""reference_id"": ""RHEA:15806"", ""source_assertion"": ""RHEA:15806 assigns CHEBI:43474 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/15806 rh:products; http://rdf.rhea-db.org/15805_R rh:contains1 http://rdf.rhea-db.org/Participant_15805_compound_5518; rh:compound http://rdf.rhea-db.org/Compound_5518""}]"	"[{""id"": ""RHEA:15806"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 15806"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-064_7d32ab3b133b	RHEA:15806	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15806		"[{""reference_id"": ""RHEA:15806"", ""source_assertion"": ""RHEA:15806 assigns CHEBI:15378 to products, coefficient 3; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/15806 rh:products; http://rdf.rhea-db.org/15805_R rh:contains3 http://rdf.rhea-db.org/Participant_15805_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249""}]"	"[{""id"": ""RHEA:15806"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 15806"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-065_2300e804686d	CHEBI:149473	pathwaymech:consumes	RHEA:22061	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22061	Formal Rhea sulfur-carrier/ferredoxin equation; the E. coli primary assay uses flavodoxin with ferredoxin/flavodoxin-NADP reductase and NADPH. These generic states do not identify that physiological donor or a specific sulfur-donor protein.	"[{""reference_id"": ""RHEA:22061"", ""source_assertion"": ""RHEA:22061 assigns CHEBI:149473 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/22061 rh:substrates; http://rdf.rhea-db.org/22060_L rh:contains1 http://rdf.rhea-db.org/Participant_22060_compound_16404; rh:compound http://rdf.rhea-db.org/Compound_16404""}]"	"[{""id"": ""RHEA:22061"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 22061"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-066_a3ae17213dda	RHEA-COMP:14737	pathwaymech:consumes	RHEA:22061	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22061	Formal Rhea sulfur-carrier/ferredoxin equation; the E. coli primary assay uses flavodoxin with ferredoxin/flavodoxin-NADP reductase and NADPH. These generic states do not identify that physiological donor or a specific sulfur-donor protein.	"[{""reference_id"": ""RHEA:22061"", ""source_assertion"": ""RHEA:22061 assigns RHEA-COMP:14737 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/22061 rh:substrates; http://rdf.rhea-db.org/22060_L rh:contains1 http://rdf.rhea-db.org/Participant_22060_compound_14737; rh:compound http://rdf.rhea-db.org/Compound_14737""}]"	"[{""id"": ""RHEA:22061"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 22061"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-067_08038b430910	RHEA-COMP:10001	pathwaymech:consumes	RHEA:22061	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22061	Formal Rhea sulfur-carrier/ferredoxin equation; the E. coli primary assay uses flavodoxin with ferredoxin/flavodoxin-NADP reductase and NADPH. These generic states do not identify that physiological donor or a specific sulfur-donor protein.	"[{""reference_id"": ""RHEA:22061"", ""source_assertion"": ""RHEA:22061 assigns RHEA-COMP:10001 to substrates, coefficient 2; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/22061 rh:substrates; http://rdf.rhea-db.org/22060_L rh:contains2 http://rdf.rhea-db.org/Participant_22060_compound_10001; rh:compound http://rdf.rhea-db.org/Compound_10001""}]"	"[{""id"": ""RHEA:22061"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 22061"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-068_7e8da8fae502	CHEBI:59789	pathwaymech:consumes	RHEA:22061	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22061	Formal Rhea sulfur-carrier/ferredoxin equation; the E. coli primary assay uses flavodoxin with ferredoxin/flavodoxin-NADP reductase and NADPH. These generic states do not identify that physiological donor or a specific sulfur-donor protein.	"[{""reference_id"": ""RHEA:22061"", ""source_assertion"": ""RHEA:22061 assigns CHEBI:59789 to substrates, coefficient 2; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/22061 rh:substrates; http://rdf.rhea-db.org/22060_L rh:contains2 http://rdf.rhea-db.org/Participant_22060_compound_6127; rh:compound http://rdf.rhea-db.org/Compound_6127""}]"	"[{""id"": ""RHEA:22061"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 22061"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-069_d7dcc42af5b7	RHEA:22061	pathwaymech:produces	RHEA-COMP:14739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22061	Formal Rhea sulfur-carrier/ferredoxin equation; the E. coli primary assay uses flavodoxin with ferredoxin/flavodoxin-NADP reductase and NADPH. These generic states do not identify that physiological donor or a specific sulfur-donor protein.	"[{""reference_id"": ""RHEA:22061"", ""source_assertion"": ""RHEA:22061 assigns RHEA-COMP:14739 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/22061 rh:products; http://rdf.rhea-db.org/22060_R rh:contains1 http://rdf.rhea-db.org/Participant_22060_compound_14739; rh:compound http://rdf.rhea-db.org/Compound_14739""}]"	"[{""id"": ""RHEA:22061"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 22061"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-070_459f22a1627d	RHEA:22061	pathwaymech:produces	CHEBI:57586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22061	Formal Rhea sulfur-carrier/ferredoxin equation; the E. coli primary assay uses flavodoxin with ferredoxin/flavodoxin-NADP reductase and NADPH. These generic states do not identify that physiological donor or a specific sulfur-donor protein.	"[{""reference_id"": ""RHEA:22061"", ""source_assertion"": ""RHEA:22061 assigns CHEBI:57586 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/22061 rh:products; http://rdf.rhea-db.org/22060_R rh:contains1 http://rdf.rhea-db.org/Participant_22060_compound_2770; rh:compound http://rdf.rhea-db.org/Compound_2770""}]"	"[{""id"": ""RHEA:22061"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 22061"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-071_55a17877c169	RHEA:22061	pathwaymech:produces	CHEBI:17319	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22061	Formal Rhea sulfur-carrier/ferredoxin equation; the E. coli primary assay uses flavodoxin with ferredoxin/flavodoxin-NADP reductase and NADPH. These generic states do not identify that physiological donor or a specific sulfur-donor protein.	"[{""reference_id"": ""RHEA:22061"", ""source_assertion"": ""RHEA:22061 assigns CHEBI:17319 to products, coefficient 2; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/22061 rh:products; http://rdf.rhea-db.org/22060_R rh:contains2 http://rdf.rhea-db.org/Participant_22060_compound_2028; rh:compound http://rdf.rhea-db.org/Compound_2028""}]"	"[{""id"": ""RHEA:22061"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 22061"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-072_377f11684968	RHEA:22061	pathwaymech:produces	CHEBI:57844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22061	Formal Rhea sulfur-carrier/ferredoxin equation; the E. coli primary assay uses flavodoxin with ferredoxin/flavodoxin-NADP reductase and NADPH. These generic states do not identify that physiological donor or a specific sulfur-donor protein.	"[{""reference_id"": ""RHEA:22061"", ""source_assertion"": ""RHEA:22061 assigns CHEBI:57844 to products, coefficient 2; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/22061 rh:products; http://rdf.rhea-db.org/22060_R rh:contains2 http://rdf.rhea-db.org/Participant_22060_compound_2530; rh:compound http://rdf.rhea-db.org/Compound_2530""}]"	"[{""id"": ""RHEA:22061"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 22061"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-073_fda58b2c9cf0	RHEA:22061	pathwaymech:produces	RHEA-COMP:10000	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22061	Formal Rhea sulfur-carrier/ferredoxin equation; the E. coli primary assay uses flavodoxin with ferredoxin/flavodoxin-NADP reductase and NADPH. These generic states do not identify that physiological donor or a specific sulfur-donor protein.	"[{""reference_id"": ""RHEA:22061"", ""source_assertion"": ""RHEA:22061 assigns RHEA-COMP:10000 to products, coefficient 2; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/22061 rh:products; http://rdf.rhea-db.org/22060_R rh:contains2 http://rdf.rhea-db.org/Participant_22060_compound_10000; rh:compound http://rdf.rhea-db.org/Compound_10000""}]"	"[{""id"": ""RHEA:22061"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 22061"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-074_64c1c3fc2b90	RHEA:17106	BFO:0000050	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY|MetaCyc:PWY-6519|MetaCyc:RXN-11475|RHEA:17106		"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""The native child pathway lists RXN-11475 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-list/Reaction[@frameid='RXN-11475']""}, {""reference_id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_assertion"": ""The complete parent contains child pathways PWY-6519 and PWY0-1507; PWY-6519 is one of these two members."", ""source_locator"": ""Pathway[@frameid='BIOTIN-BIOSYNTHESIS-PWY']/sub-pathways; reaction-list""}, {""reference_id"": ""MetaCyc:RXN-11475"", ""source_assertion"": ""Native reaction RXN-11475 defines the corresponding substrate/product transformation; its Rhea cross-reference is 34900, not an assertion of a different current identifier."", ""source_locator"": ""Reaction[@frameid='RXN-11475']/left; right; dblink[dblink-db='RHEA']""}, {""reference_id"": ""RHEA:17106"", ""source_assertion"": ""Current directed RHEA:17106 supplies the independently inspected normalized equation for this step; correspondence uses substrate/product chemistry and the current catalyst annotation."", ""source_locator"": ""http://rdf.rhea-db.org/17106 rdfs:label; rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_sha256"": ""91cbfd0409aef504a0a2dad6f35030bec28fa3da1cea70310cf6901b9f023243"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""biotin biosynthesis I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-BIOSYNTHESIS-PWY""}, {""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}, {""id"": ""MetaCyc:RXN-11475"", ""source_sha256"": ""7c49babc612cf79a9e814337b4cbada4325f5b193a2dc8a041a68a851863a09b"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""RXN-11475"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11475""}, {""id"": ""RHEA:17106"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 17106"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-075_ad09032095fd	MetaCyc:RXN-11474	BFO:0000050	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY|MetaCyc:PWY-6519		"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""The native child pathway lists RXN-11474 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-list/Reaction[@frameid='RXN-11474']""}, {""reference_id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_assertion"": ""The complete parent contains child pathways PWY-6519 and PWY0-1507; PWY-6519 is one of these two members."", ""source_locator"": ""Pathway[@frameid='BIOTIN-BIOSYNTHESIS-PWY']/sub-pathways; reaction-list""}]"	"[{""id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_sha256"": ""91cbfd0409aef504a0a2dad6f35030bec28fa3da1cea70310cf6901b9f023243"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""biotin biosynthesis I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-BIOSYNTHESIS-PWY""}, {""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-076_3fa90eb92f0a	MetaCyc:RXN-11476	BFO:0000050	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY|MetaCyc:PWY-6519		"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""The native child pathway lists RXN-11476 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-list/Reaction[@frameid='RXN-11476']""}, {""reference_id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_assertion"": ""The complete parent contains child pathways PWY-6519 and PWY0-1507; PWY-6519 is one of these two members."", ""source_locator"": ""Pathway[@frameid='BIOTIN-BIOSYNTHESIS-PWY']/sub-pathways; reaction-list""}]"	"[{""id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_sha256"": ""91cbfd0409aef504a0a2dad6f35030bec28fa3da1cea70310cf6901b9f023243"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""biotin biosynthesis I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-BIOSYNTHESIS-PWY""}, {""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-077_e5f610039b33	MetaCyc:RXN-11477	BFO:0000050	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY|MetaCyc:PWY-6519		"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""The native child pathway lists RXN-11477 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-list/Reaction[@frameid='RXN-11477']""}, {""reference_id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_assertion"": ""The complete parent contains child pathways PWY-6519 and PWY0-1507; PWY-6519 is one of these two members."", ""source_locator"": ""Pathway[@frameid='BIOTIN-BIOSYNTHESIS-PWY']/sub-pathways; reaction-list""}]"	"[{""id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_sha256"": ""91cbfd0409aef504a0a2dad6f35030bec28fa3da1cea70310cf6901b9f023243"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""biotin biosynthesis I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-BIOSYNTHESIS-PWY""}, {""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-078_1f61f01a3d9b	MetaCyc:RXN-11478	BFO:0000050	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY|MetaCyc:PWY-6519		"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""The native child pathway lists RXN-11478 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-list/Reaction[@frameid='RXN-11478']""}, {""reference_id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_assertion"": ""The complete parent contains child pathways PWY-6519 and PWY0-1507; PWY-6519 is one of these two members."", ""source_locator"": ""Pathway[@frameid='BIOTIN-BIOSYNTHESIS-PWY']/sub-pathways; reaction-list""}]"	"[{""id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_sha256"": ""91cbfd0409aef504a0a2dad6f35030bec28fa3da1cea70310cf6901b9f023243"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""biotin biosynthesis I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-BIOSYNTHESIS-PWY""}, {""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-079_4599cde4af93	MetaCyc:RXN-11479	BFO:0000050	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY|MetaCyc:PWY-6519		"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""The native child pathway lists RXN-11479 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-list/Reaction[@frameid='RXN-11479']""}, {""reference_id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_assertion"": ""The complete parent contains child pathways PWY-6519 and PWY0-1507; PWY-6519 is one of these two members."", ""source_locator"": ""Pathway[@frameid='BIOTIN-BIOSYNTHESIS-PWY']/sub-pathways; reaction-list""}]"	"[{""id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_sha256"": ""91cbfd0409aef504a0a2dad6f35030bec28fa3da1cea70310cf6901b9f023243"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""biotin biosynthesis I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-BIOSYNTHESIS-PWY""}, {""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-080_7c2cdedceb0c	MetaCyc:RXN-11480	BFO:0000050	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY|MetaCyc:PWY-6519		"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""The native child pathway lists RXN-11480 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-list/Reaction[@frameid='RXN-11480']""}, {""reference_id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_assertion"": ""The complete parent contains child pathways PWY-6519 and PWY0-1507; PWY-6519 is one of these two members."", ""source_locator"": ""Pathway[@frameid='BIOTIN-BIOSYNTHESIS-PWY']/sub-pathways; reaction-list""}]"	"[{""id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_sha256"": ""91cbfd0409aef504a0a2dad6f35030bec28fa3da1cea70310cf6901b9f023243"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""biotin biosynthesis I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-BIOSYNTHESIS-PWY""}, {""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-081_3637b1f3b4db	MetaCyc:RXN-11481	BFO:0000050	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY|MetaCyc:PWY-6519		"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""The native child pathway lists RXN-11481 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-list/Reaction[@frameid='RXN-11481']""}, {""reference_id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_assertion"": ""The complete parent contains child pathways PWY-6519 and PWY0-1507; PWY-6519 is one of these two members."", ""source_locator"": ""Pathway[@frameid='BIOTIN-BIOSYNTHESIS-PWY']/sub-pathways; reaction-list""}]"	"[{""id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_sha256"": ""91cbfd0409aef504a0a2dad6f35030bec28fa3da1cea70310cf6901b9f023243"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""biotin biosynthesis I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-BIOSYNTHESIS-PWY""}, {""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-082_8693bc2fbd8c	MetaCyc:RXN-11482	BFO:0000050	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY|MetaCyc:PWY-6519		"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""The native child pathway lists RXN-11482 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-list/Reaction[@frameid='RXN-11482']""}, {""reference_id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_assertion"": ""The complete parent contains child pathways PWY-6519 and PWY0-1507; PWY-6519 is one of these two members."", ""source_locator"": ""Pathway[@frameid='BIOTIN-BIOSYNTHESIS-PWY']/sub-pathways; reaction-list""}]"	"[{""id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_sha256"": ""91cbfd0409aef504a0a2dad6f35030bec28fa3da1cea70310cf6901b9f023243"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""biotin biosynthesis I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-BIOSYNTHESIS-PWY""}, {""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-083_54f21e3bea38	RHEA:42701	BFO:0000050	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY|MetaCyc:PWY-6519|MetaCyc:RXN-11483|RHEA:42701		"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""The native child pathway lists RXN-11483 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-list/Reaction[@frameid='RXN-11483']""}, {""reference_id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_assertion"": ""The complete parent contains child pathways PWY-6519 and PWY0-1507; PWY-6519 is one of these two members."", ""source_locator"": ""Pathway[@frameid='BIOTIN-BIOSYNTHESIS-PWY']/sub-pathways; reaction-list""}, {""reference_id"": ""MetaCyc:RXN-11483"", ""source_assertion"": ""Native reaction RXN-11483 defines the corresponding substrate/product transformation; its Rhea cross-reference is 42701, not an assertion of a different current identifier."", ""source_locator"": ""Reaction[@frameid='RXN-11483']/left; right; dblink[dblink-db='RHEA']""}, {""reference_id"": ""RHEA:42701"", ""source_assertion"": ""Current directed RHEA:42701 supplies the independently inspected normalized equation for this step; correspondence uses substrate/product chemistry and the current catalyst annotation."", ""source_locator"": ""http://rdf.rhea-db.org/42701 rdfs:label; rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_sha256"": ""91cbfd0409aef504a0a2dad6f35030bec28fa3da1cea70310cf6901b9f023243"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""biotin biosynthesis I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-BIOSYNTHESIS-PWY""}, {""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}, {""id"": ""MetaCyc:RXN-11483"", ""source_sha256"": ""5887dca501fd912d1c7ccbe823a55480c14a89a6dfec0a781f40a1d655a75870"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""RXN-11483"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11483""}, {""id"": ""RHEA:42701"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42701"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-084_0bb63718a408	RHEA:42289	BFO:0000050	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY|MetaCyc:PWY-6519|MetaCyc:RXN-11484|RHEA:42289		"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""The native child pathway lists RXN-11484 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-list/Reaction[@frameid='RXN-11484']""}, {""reference_id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_assertion"": ""The complete parent contains child pathways PWY-6519 and PWY0-1507; PWY-6519 is one of these two members."", ""source_locator"": ""Pathway[@frameid='BIOTIN-BIOSYNTHESIS-PWY']/sub-pathways; reaction-list""}, {""reference_id"": ""MetaCyc:RXN-11484"", ""source_assertion"": ""Native reaction RXN-11484 defines the corresponding substrate/product transformation; its Rhea cross-reference is 42289, not an assertion of a different current identifier."", ""source_locator"": ""Reaction[@frameid='RXN-11484']/left; right; dblink[dblink-db='RHEA']""}, {""reference_id"": ""RHEA:42289"", ""source_assertion"": ""Current directed RHEA:42289 supplies the independently inspected normalized equation for this step; correspondence uses substrate/product chemistry and the current catalyst annotation."", ""source_locator"": ""http://rdf.rhea-db.org/42289 rdfs:label; rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_sha256"": ""91cbfd0409aef504a0a2dad6f35030bec28fa3da1cea70310cf6901b9f023243"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""biotin biosynthesis I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-BIOSYNTHESIS-PWY""}, {""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}, {""id"": ""MetaCyc:RXN-11484"", ""source_sha256"": ""2e5278a333a99e174ec4fd91128aa95e9e75ad3ad7a44ad3af57582a2eb4fc0d"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""RXN-11484"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11484""}, {""id"": ""RHEA:42289"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42289"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-085_2a218b77d28f	RHEA:16862	BFO:0000050	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY|MetaCyc:DAPASYN-RXN|MetaCyc:PWY0-1507|RHEA:16862		"[{""reference_id"": ""MetaCyc:PWY0-1507"", ""source_assertion"": ""The native child pathway lists DAPASYN-RXN as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY0-1507']/reaction-list/Reaction[@frameid='DAPASYN-RXN']""}, {""reference_id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_assertion"": ""The complete parent contains child pathways PWY-6519 and PWY0-1507; PWY0-1507 is one of these two members."", ""source_locator"": ""Pathway[@frameid='BIOTIN-BIOSYNTHESIS-PWY']/sub-pathways; reaction-list""}, {""reference_id"": ""MetaCyc:DAPASYN-RXN"", ""source_assertion"": ""Native reaction DAPASYN-RXN defines the corresponding substrate/product transformation; its Rhea cross-reference is 16864, not an assertion of a different current identifier."", ""source_locator"": ""Reaction[@frameid='DAPASYN-RXN']/left; right; dblink[dblink-db='RHEA']""}, {""reference_id"": ""RHEA:16862"", ""source_assertion"": ""Current directed RHEA:16862 supplies the independently inspected normalized equation for this step; correspondence uses substrate/product chemistry and the current catalyst annotation."", ""source_locator"": ""http://rdf.rhea-db.org/16862 rdfs:label; rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_sha256"": ""91cbfd0409aef504a0a2dad6f35030bec28fa3da1cea70310cf6901b9f023243"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""biotin biosynthesis I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-BIOSYNTHESIS-PWY""}, {""id"": ""MetaCyc:DAPASYN-RXN"", ""source_sha256"": ""31cc32ea1c8161409001bbd016660a538e8cf3ce17ebcef1caadb0a49a1c22e7"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""DAPASYN-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DAPASYN-RXN""}, {""id"": ""MetaCyc:PWY0-1507"", ""source_sha256"": ""0c5cff1a8b72ef4ae2b75528d72de441b9876633e69e2aa75f20389402b9bd25"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY0-1507"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1507""}, {""id"": ""RHEA:16862"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 16862"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-086_f4e231026646	RHEA:15806	BFO:0000050	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY|MetaCyc:DETHIOBIOTIN-SYN-RXN|MetaCyc:PWY0-1507|RHEA:15806		"[{""reference_id"": ""MetaCyc:PWY0-1507"", ""source_assertion"": ""The native child pathway lists DETHIOBIOTIN-SYN-RXN as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY0-1507']/reaction-list/Reaction[@frameid='DETHIOBIOTIN-SYN-RXN']""}, {""reference_id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_assertion"": ""The complete parent contains child pathways PWY-6519 and PWY0-1507; PWY0-1507 is one of these two members."", ""source_locator"": ""Pathway[@frameid='BIOTIN-BIOSYNTHESIS-PWY']/sub-pathways; reaction-list""}, {""reference_id"": ""MetaCyc:DETHIOBIOTIN-SYN-RXN"", ""source_assertion"": ""Native reaction DETHIOBIOTIN-SYN-RXN defines the corresponding substrate/product transformation; its Rhea cross-reference is 15805, not an assertion of a different current identifier."", ""source_locator"": ""Reaction[@frameid='DETHIOBIOTIN-SYN-RXN']/left; right; dblink[dblink-db='RHEA']""}, {""reference_id"": ""RHEA:15806"", ""source_assertion"": ""Current directed RHEA:15806 supplies the independently inspected normalized equation for this step; correspondence uses substrate/product chemistry and the current catalyst annotation."", ""source_locator"": ""http://rdf.rhea-db.org/15806 rdfs:label; rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_sha256"": ""91cbfd0409aef504a0a2dad6f35030bec28fa3da1cea70310cf6901b9f023243"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""biotin biosynthesis I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-BIOSYNTHESIS-PWY""}, {""id"": ""MetaCyc:DETHIOBIOTIN-SYN-RXN"", ""source_sha256"": ""55f864ef8f8e8479594753bfa7fd72466fa8e60d82cb0775a07ba4d3c0da68c8"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""DETHIOBIOTIN-SYN-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DETHIOBIOTIN-SYN-RXN""}, {""id"": ""MetaCyc:PWY0-1507"", ""source_sha256"": ""0c5cff1a8b72ef4ae2b75528d72de441b9876633e69e2aa75f20389402b9bd25"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY0-1507"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1507""}, {""id"": ""RHEA:15806"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 15806"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-087_6ac01c6c170f	RHEA:22061	BFO:0000050	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:2.8.1.6-RXN|MetaCyc:BIOTIN-BIOSYNTHESIS-PWY|MetaCyc:PWY0-1507|RHEA:22061		"[{""reference_id"": ""MetaCyc:PWY0-1507"", ""source_assertion"": ""The native child pathway lists 2.8.1.6-RXN as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY0-1507']/reaction-list/Reaction[@frameid='2.8.1.6-RXN']""}, {""reference_id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_assertion"": ""The complete parent contains child pathways PWY-6519 and PWY0-1507; PWY0-1507 is one of these two members."", ""source_locator"": ""Pathway[@frameid='BIOTIN-BIOSYNTHESIS-PWY']/sub-pathways; reaction-list""}, {""reference_id"": ""MetaCyc:2.8.1.6-RXN"", ""source_assertion"": ""Native reaction 2.8.1.6-RXN defines the corresponding substrate/product transformation; its Rhea cross-reference is 22061, not an assertion of a different current identifier."", ""source_locator"": ""Reaction[@frameid='2.8.1.6-RXN']/left; right; dblink[dblink-db='RHEA']""}, {""reference_id"": ""RHEA:22061"", ""source_assertion"": ""Current directed RHEA:22061 supplies the independently inspected normalized equation for this step; correspondence uses substrate/product chemistry and the current catalyst annotation."", ""source_locator"": ""http://rdf.rhea-db.org/22061 rdfs:label; rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:2.8.1.6-RXN"", ""source_sha256"": ""f2a986d1984be27142886c9cad76c8a0d4b329c67fcee07093067dc95117327d"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""2.8.1.6-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:2.8.1.6-RXN""}, {""id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_sha256"": ""91cbfd0409aef504a0a2dad6f35030bec28fa3da1cea70310cf6901b9f023243"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""biotin biosynthesis I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-BIOSYNTHESIS-PWY""}, {""id"": ""MetaCyc:PWY0-1507"", ""source_sha256"": ""0c5cff1a8b72ef4ae2b75528d72de441b9876633e69e2aa75f20389402b9bd25"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY0-1507"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1507""}, {""id"": ""RHEA:22061"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 22061"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-088_cad8c36d9217	RHEA:17106	pathwaymech:precedes	MetaCyc:RXN-11474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6519|MetaCyc:RXN-11474|RHEA:17106	Sequential intermediate: RHEA-COMP:9954. This ordering does not assert physical substrate channeling.	"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""Native reaction-ordering places RXN-11475 before RXN-11474; the separately cited chemical sides identify the shared intermediate."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-ordering[Reaction/@frameid='RXN-11474']/predecessor-reactions/Reaction[@frameid='RXN-11475']""}, {""reference_id"": ""RHEA:17106"", ""source_assertion"": ""RHEA:17106 assigns RHEA-COMP:9954 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/17106 rh:products; http://rdf.rhea-db.org/17105_R rh:contains1 http://rdf.rhea-db.org/Participant_17105_compound_9954; rh:compound http://rdf.rhea-db.org/Compound_9954""}, {""reference_id"": ""MetaCyc:RXN-11474"", ""source_assertion"": ""Native RXN-11474 has Malonyl-acp-methyl-ester on left, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11474']/left/*[@frameid='Malonyl-acp-methyl-ester']; sibling coefficient (absent means 1); reaction-direction""}, {""reference_id"": ""RHEA:17106"", ""source_assertion"": ""Independent Rhea whole-carrier identity used for the native ACP state: RHEA-COMP:9954; reactive-part ChEBI is not the whole carrier."", ""source_locator"": ""http://rdf.rhea-db.org/Compound_9954 rh:name; rh:reactivePart""}]"	"[{""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}, {""id"": ""MetaCyc:RXN-11474"", ""source_sha256"": ""40d8fba7b90960555167184303a1263ffc6634ea3b76aed61c6f486e6549e952"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a malonyl-[acp] methyl ester + a malonyl-[acp] + H+ -> a 3-oxoglutaryl-[acp] methyl ester + CO2 + acyl-carrier protein"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11474""}, {""id"": ""RHEA:17106"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 17106"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-089_519b42770e88	MetaCyc:RXN-11474	pathwaymech:precedes	MetaCyc:RXN-11476	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6519|MetaCyc:RXN-11474|MetaCyc:RXN-11476	Sequential intermediate: MetaCyc:3-Ketoglutaryl-ACP-methyl-ester. This ordering does not assert physical substrate channeling.	"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""Native reaction-ordering places RXN-11474 before RXN-11476; the separately cited chemical sides identify the shared intermediate."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-ordering[Reaction/@frameid='RXN-11476']/predecessor-reactions/Reaction[@frameid='RXN-11474']""}, {""reference_id"": ""MetaCyc:RXN-11474"", ""source_assertion"": ""Native RXN-11474 has 3-Ketoglutaryl-ACP-methyl-ester on right, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11474']/right/*[@frameid='3-Ketoglutaryl-ACP-methyl-ester']; sibling coefficient (absent means 1); reaction-direction""}, {""reference_id"": ""MetaCyc:RXN-11476"", ""source_assertion"": ""Native RXN-11476 has 3-Ketoglutaryl-ACP-methyl-ester on right, coefficient 1; physiological direction PHYSIOL-RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11476']/right/*[@frameid='3-Ketoglutaryl-ACP-methyl-ester']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}, {""id"": ""MetaCyc:RXN-11474"", ""source_sha256"": ""40d8fba7b90960555167184303a1263ffc6634ea3b76aed61c6f486e6549e952"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a malonyl-[acp] methyl ester + a malonyl-[acp] + H+ -> a 3-oxoglutaryl-[acp] methyl ester + CO2 + acyl-carrier protein"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11474""}, {""id"": ""MetaCyc:RXN-11476"", ""source_sha256"": ""59600a069a2df429da311f8da1b0bb9ad8a928bb9593af86b4b880e619c00436"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxyglutaryl-[acp] methyl ester + NADP+ <- a 3-oxoglutaryl-[acp] methyl ester + NADPH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11476""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-090_d8f265ac1a28	MetaCyc:RXN-11476	pathwaymech:precedes	MetaCyc:RXN-11477	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6519|MetaCyc:RXN-11476|MetaCyc:RXN-11477	Sequential intermediate: MetaCyc:3-Hydroxyglutaryl-ACP-methyl-ester. This ordering does not assert physical substrate channeling.	"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""Native reaction-ordering places RXN-11476 before RXN-11477; the separately cited chemical sides identify the shared intermediate."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-ordering[Reaction/@frameid='RXN-11477']/predecessor-reactions/Reaction[@frameid='RXN-11476']""}, {""reference_id"": ""MetaCyc:RXN-11476"", ""source_assertion"": ""Native RXN-11476 has 3-Hydroxyglutaryl-ACP-methyl-ester on left, coefficient 1; physiological direction PHYSIOL-RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11476']/left/*[@frameid='3-Hydroxyglutaryl-ACP-methyl-ester']; sibling coefficient (absent means 1); reaction-direction""}, {""reference_id"": ""MetaCyc:RXN-11477"", ""source_assertion"": ""Native RXN-11477 has 3-Hydroxyglutaryl-ACP-methyl-ester on left, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11477']/left/*[@frameid='3-Hydroxyglutaryl-ACP-methyl-ester']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}, {""id"": ""MetaCyc:RXN-11476"", ""source_sha256"": ""59600a069a2df429da311f8da1b0bb9ad8a928bb9593af86b4b880e619c00436"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxyglutaryl-[acp] methyl ester + NADP+ <- a 3-oxoglutaryl-[acp] methyl ester + NADPH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11476""}, {""id"": ""MetaCyc:RXN-11477"", ""source_sha256"": ""8021d303f182bb7be60e1f94d8855c02a1444eb9595c303c4738416b40a8b731"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxyglutaryl-[acp] methyl ester -> an enoylglutaryl-[acp] methyl ester + H2O"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11477""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-091_649824eeb33f	MetaCyc:RXN-11477	pathwaymech:precedes	MetaCyc:RXN-11478	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6519|MetaCyc:RXN-11477|MetaCyc:RXN-11478	Sequential intermediate: MetaCyc:Enoylglutaryl-ACP-methyl-esters. This ordering does not assert physical substrate channeling.	"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""Native reaction-ordering places RXN-11477 before RXN-11478; the separately cited chemical sides identify the shared intermediate."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-ordering[Reaction/@frameid='RXN-11478']/predecessor-reactions/Reaction[@frameid='RXN-11477']""}, {""reference_id"": ""MetaCyc:RXN-11477"", ""source_assertion"": ""Native RXN-11477 has Enoylglutaryl-ACP-methyl-esters on right, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11477']/right/*[@frameid='Enoylglutaryl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}, {""reference_id"": ""MetaCyc:RXN-11478"", ""source_assertion"": ""Native RXN-11478 has Enoylglutaryl-ACP-methyl-esters on right, coefficient 1; physiological direction RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11478']/right/*[@frameid='Enoylglutaryl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}, {""id"": ""MetaCyc:RXN-11477"", ""source_sha256"": ""8021d303f182bb7be60e1f94d8855c02a1444eb9595c303c4738416b40a8b731"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxyglutaryl-[acp] methyl ester -> an enoylglutaryl-[acp] methyl ester + H2O"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11477""}, {""id"": ""MetaCyc:RXN-11478"", ""source_sha256"": ""002a05ab29160873d0b3e9960baf4759d68d30bcaea7bcc213abdd5503003968"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a glutaryl-[acp] methyl ester + NAD+ <- an enoylglutaryl-[acp] methyl ester + NADH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11478""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-092_c519cb7e19cd	MetaCyc:RXN-11478	pathwaymech:precedes	MetaCyc:RXN-11479	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6519|MetaCyc:RXN-11478|MetaCyc:RXN-11479	Sequential intermediate: MetaCyc:Glutaryl-ACP-methyl-esters. This ordering does not assert physical substrate channeling.	"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""Native reaction-ordering places RXN-11478 before RXN-11479; the separately cited chemical sides identify the shared intermediate."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-ordering[Reaction/@frameid='RXN-11479']/predecessor-reactions/Reaction[@frameid='RXN-11478']""}, {""reference_id"": ""MetaCyc:RXN-11478"", ""source_assertion"": ""Native RXN-11478 has Glutaryl-ACP-methyl-esters on left, coefficient 1; physiological direction RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11478']/left/*[@frameid='Glutaryl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}, {""reference_id"": ""MetaCyc:RXN-11479"", ""source_assertion"": ""Native RXN-11479 has Glutaryl-ACP-methyl-esters on left, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11479']/left/*[@frameid='Glutaryl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}, {""id"": ""MetaCyc:RXN-11478"", ""source_sha256"": ""002a05ab29160873d0b3e9960baf4759d68d30bcaea7bcc213abdd5503003968"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a glutaryl-[acp] methyl ester + NAD+ <- an enoylglutaryl-[acp] methyl ester + NADH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11478""}, {""id"": ""MetaCyc:RXN-11479"", ""source_sha256"": ""46432517a765cc21bde5e9d697a0a1e8997e7d233268c80335aac91f09f3de23"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a glutaryl-[acp] methyl ester + a malonyl-[acp] + H+ -> a 3-oxopimeloyl-[acp] methyl ester + CO2 + acyl-carrier protein"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11479""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-093_72c635c99b6a	MetaCyc:RXN-11479	pathwaymech:precedes	MetaCyc:RXN-11480	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6519|MetaCyc:RXN-11479|MetaCyc:RXN-11480	Sequential intermediate: MetaCyc:3-Ketopimeloyl-ACP-methyl-esters. This ordering does not assert physical substrate channeling.	"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""Native reaction-ordering places RXN-11479 before RXN-11480; the separately cited chemical sides identify the shared intermediate."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-ordering[Reaction/@frameid='RXN-11480']/predecessor-reactions/Reaction[@frameid='RXN-11479']""}, {""reference_id"": ""MetaCyc:RXN-11479"", ""source_assertion"": ""Native RXN-11479 has 3-Ketopimeloyl-ACP-methyl-esters on right, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11479']/right/*[@frameid='3-Ketopimeloyl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}, {""reference_id"": ""MetaCyc:RXN-11480"", ""source_assertion"": ""Native RXN-11480 has 3-Ketopimeloyl-ACP-methyl-esters on right, coefficient 1; physiological direction PHYSIOL-RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11480']/right/*[@frameid='3-Ketopimeloyl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}, {""id"": ""MetaCyc:RXN-11479"", ""source_sha256"": ""46432517a765cc21bde5e9d697a0a1e8997e7d233268c80335aac91f09f3de23"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a glutaryl-[acp] methyl ester + a malonyl-[acp] + H+ -> a 3-oxopimeloyl-[acp] methyl ester + CO2 + acyl-carrier protein"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11479""}, {""id"": ""MetaCyc:RXN-11480"", ""source_sha256"": ""47717a29c484666a17446e09815017beffb101577e34d0ec39ba666ed54fae89"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxypimeloyl-[acp] methyl ester + NADP+ <- a 3-oxopimeloyl-[acp] methyl ester + NADPH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11480""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-094_6aea60283270	MetaCyc:RXN-11480	pathwaymech:precedes	MetaCyc:RXN-11481	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6519|MetaCyc:RXN-11480|MetaCyc:RXN-11481	Sequential intermediate: MetaCyc:3-hydroxypimeloyl-ACP-methyl-esters. This ordering does not assert physical substrate channeling.	"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""Native reaction-ordering places RXN-11480 before RXN-11481; the separately cited chemical sides identify the shared intermediate."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-ordering[Reaction/@frameid='RXN-11481']/predecessor-reactions/Reaction[@frameid='RXN-11480']""}, {""reference_id"": ""MetaCyc:RXN-11480"", ""source_assertion"": ""Native RXN-11480 has 3-hydroxypimeloyl-ACP-methyl-esters on left, coefficient 1; physiological direction PHYSIOL-RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11480']/left/*[@frameid='3-hydroxypimeloyl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}, {""reference_id"": ""MetaCyc:RXN-11481"", ""source_assertion"": ""Native RXN-11481 has 3-hydroxypimeloyl-ACP-methyl-esters on left, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11481']/left/*[@frameid='3-hydroxypimeloyl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}, {""id"": ""MetaCyc:RXN-11480"", ""source_sha256"": ""47717a29c484666a17446e09815017beffb101577e34d0ec39ba666ed54fae89"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxypimeloyl-[acp] methyl ester + NADP+ <- a 3-oxopimeloyl-[acp] methyl ester + NADPH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11480""}, {""id"": ""MetaCyc:RXN-11481"", ""source_sha256"": ""fec1c07b64a99225356a74d0ee7f83bc2d6d454f3b336c269bc1153474539dc3"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxypimeloyl-[acp] methyl ester -> an enoylpimeloyl-[acp] methyl ester + H2O"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11481""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-095_ede04f536486	MetaCyc:RXN-11481	pathwaymech:precedes	MetaCyc:RXN-11482	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6519|MetaCyc:RXN-11481|MetaCyc:RXN-11482	Sequential intermediate: MetaCyc:Enoylpimeloyl-ACP-methyl-esters. This ordering does not assert physical substrate channeling.	"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""Native reaction-ordering places RXN-11481 before RXN-11482; the separately cited chemical sides identify the shared intermediate."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-ordering[Reaction/@frameid='RXN-11482']/predecessor-reactions/Reaction[@frameid='RXN-11481']""}, {""reference_id"": ""MetaCyc:RXN-11481"", ""source_assertion"": ""Native RXN-11481 has Enoylpimeloyl-ACP-methyl-esters on right, coefficient 1; physiological direction LEFT-TO-RIGHT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11481']/right/*[@frameid='Enoylpimeloyl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}, {""reference_id"": ""MetaCyc:RXN-11482"", ""source_assertion"": ""Native RXN-11482 has Enoylpimeloyl-ACP-methyl-esters on right, coefficient 1; physiological direction RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11482']/right/*[@frameid='Enoylpimeloyl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}]"	"[{""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}, {""id"": ""MetaCyc:RXN-11481"", ""source_sha256"": ""fec1c07b64a99225356a74d0ee7f83bc2d6d454f3b336c269bc1153474539dc3"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a (3R)-3-hydroxypimeloyl-[acp] methyl ester -> an enoylpimeloyl-[acp] methyl ester + H2O"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11481""}, {""id"": ""MetaCyc:RXN-11482"", ""source_sha256"": ""994ceb2b8f748de9ec78cbf6f8bd99254b3b390fc2b4ea3578de3c0d78508828"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a pimeloyl-[acp] methyl ester + NAD+ <- an enoylpimeloyl-[acp] methyl ester + NADH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11482""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-096_29927d592485	MetaCyc:RXN-11482	pathwaymech:precedes	RHEA:42701	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6519|MetaCyc:RXN-11482|RHEA:42701	Sequential intermediate: RHEA-COMP:10186. This ordering does not assert physical substrate channeling.	"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""Native reaction-ordering places RXN-11482 before RXN-11483; the separately cited chemical sides identify the shared intermediate."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-ordering[Reaction/@frameid='RXN-11483']/predecessor-reactions/Reaction[@frameid='RXN-11482']""}, {""reference_id"": ""MetaCyc:RXN-11482"", ""source_assertion"": ""Native RXN-11482 has Pimeloyl-ACP-methyl-esters on left, coefficient 1; physiological direction RIGHT-TO-LEFT. Whole ACP classes are preserved."", ""source_locator"": ""Reaction[@frameid='RXN-11482']/left/*[@frameid='Pimeloyl-ACP-methyl-esters']; sibling coefficient (absent means 1); reaction-direction""}, {""reference_id"": ""RHEA:42701"", ""source_assertion"": ""Independent Rhea whole-carrier identity used for the native ACP state: RHEA-COMP:10186; reactive-part ChEBI is not the whole carrier."", ""source_locator"": ""http://rdf.rhea-db.org/Compound_10186 rh:name; rh:reactivePart""}, {""reference_id"": ""RHEA:42701"", ""source_assertion"": ""RHEA:42701 assigns RHEA-COMP:10186 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/42701 rh:substrates; http://rdf.rhea-db.org/42700_L rh:contains1 http://rdf.rhea-db.org/Participant_42700_compound_10186; rh:compound http://rdf.rhea-db.org/Compound_10186""}]"	"[{""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}, {""id"": ""MetaCyc:RXN-11482"", ""source_sha256"": ""994ceb2b8f748de9ec78cbf6f8bd99254b3b390fc2b4ea3578de3c0d78508828"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""a pimeloyl-[acp] methyl ester + NAD+ <- an enoylpimeloyl-[acp] methyl ester + NADH + H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11482""}, {""id"": ""RHEA:42701"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42701"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-097_39ee5786246a	RHEA:42701	pathwaymech:precedes	RHEA:42289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6519|RHEA:42289|RHEA:42701	Sequential intermediate: RHEA-COMP:9955. This ordering does not assert physical substrate channeling.	"[{""reference_id"": ""MetaCyc:PWY-6519"", ""source_assertion"": ""Native reaction-ordering places RXN-11483 before RXN-11484; the separately cited chemical sides identify the shared intermediate."", ""source_locator"": ""Pathway[@frameid='PWY-6519']/reaction-ordering[Reaction/@frameid='RXN-11484']/predecessor-reactions/Reaction[@frameid='RXN-11483']""}, {""reference_id"": ""RHEA:42701"", ""source_assertion"": ""RHEA:42701 assigns RHEA-COMP:9955 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/42701 rh:products; http://rdf.rhea-db.org/42700_R rh:contains1 http://rdf.rhea-db.org/Participant_42700_compound_9955; rh:compound http://rdf.rhea-db.org/Compound_9955""}, {""reference_id"": ""RHEA:42289"", ""source_assertion"": ""RHEA:42289 assigns RHEA-COMP:9955 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/42289 rh:substrates; http://rdf.rhea-db.org/42288_L rh:contains1 http://rdf.rhea-db.org/Participant_42288_compound_9955; rh:compound http://rdf.rhea-db.org/Compound_9955""}]"	"[{""id"": ""MetaCyc:PWY-6519"", ""source_sha256"": ""87ce2a1de769892f2c87597a52c640c73825b9d8656c97d95440cebbce3939bf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY-6519"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6519""}, {""id"": ""RHEA:42289"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42289"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:42701"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42701"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-098_3f3d94876f2c	RHEA:42289	pathwaymech:precedes	RHEA:16862	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-BIOSYNTHESIS-PWY|RHEA:16862|RHEA:42289	Sequential intermediate: CHEBI:149468. This ordering does not assert physical substrate channeling.	"[{""reference_id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_assertion"": ""Native reaction-ordering places RXN-11484 before DAPASYN-RXN; the separately cited chemical sides identify the shared intermediate."", ""source_locator"": ""Pathway[@frameid='BIOTIN-BIOSYNTHESIS-PWY']/reaction-ordering[Reaction/@frameid='DAPASYN-RXN']/predecessor-reactions/Reaction[@frameid='RXN-11484']""}, {""reference_id"": ""RHEA:42289"", ""source_assertion"": ""RHEA:42289 assigns CHEBI:149468 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/42289 rh:products; http://rdf.rhea-db.org/42288_R rh:contains1 http://rdf.rhea-db.org/Participant_42288_compound_16402; rh:compound http://rdf.rhea-db.org/Compound_16402""}, {""reference_id"": ""RHEA:16862"", ""source_assertion"": ""RHEA:16862 assigns CHEBI:149468 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/16862 rh:substrates; http://rdf.rhea-db.org/16861_L rh:contains1 http://rdf.rhea-db.org/Participant_16861_compound_16402; rh:compound http://rdf.rhea-db.org/Compound_16402""}]"	"[{""id"": ""MetaCyc:BIOTIN-BIOSYNTHESIS-PWY"", ""source_sha256"": ""91cbfd0409aef504a0a2dad6f35030bec28fa3da1cea70310cf6901b9f023243"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""biotin biosynthesis I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-BIOSYNTHESIS-PWY""}, {""id"": ""RHEA:16862"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 16862"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:42289"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 42289"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-099_f6ef86f80eb7	RHEA:16862	pathwaymech:precedes	RHEA:15806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1507|RHEA:15806|RHEA:16862	Sequential intermediate: CHEBI:149469. This ordering does not assert physical substrate channeling.	"[{""reference_id"": ""MetaCyc:PWY0-1507"", ""source_assertion"": ""Native reaction-ordering places DAPASYN-RXN before DETHIOBIOTIN-SYN-RXN; the separately cited chemical sides identify the shared intermediate."", ""source_locator"": ""Pathway[@frameid='PWY0-1507']/reaction-ordering[Reaction/@frameid='DETHIOBIOTIN-SYN-RXN']/predecessor-reactions/Reaction[@frameid='DAPASYN-RXN']""}, {""reference_id"": ""RHEA:16862"", ""source_assertion"": ""RHEA:16862 assigns CHEBI:149469 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/16862 rh:products; http://rdf.rhea-db.org/16861_R rh:contains1 http://rdf.rhea-db.org/Participant_16861_compound_16403; rh:compound http://rdf.rhea-db.org/Compound_16403""}, {""reference_id"": ""RHEA:15806"", ""source_assertion"": ""RHEA:15806 assigns CHEBI:149469 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/15806 rh:substrates; http://rdf.rhea-db.org/15805_L rh:contains1 http://rdf.rhea-db.org/Participant_15805_compound_16403; rh:compound http://rdf.rhea-db.org/Compound_16403""}]"	"[{""id"": ""MetaCyc:PWY0-1507"", ""source_sha256"": ""0c5cff1a8b72ef4ae2b75528d72de441b9876633e69e2aa75f20389402b9bd25"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY0-1507"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1507""}, {""id"": ""RHEA:15806"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 15806"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:16862"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 16862"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-100_d2aa03da685e	RHEA:15806	pathwaymech:precedes	RHEA:22061	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1507|RHEA:15806|RHEA:22061	Sequential intermediate: CHEBI:149473. This ordering does not assert physical substrate channeling.	"[{""reference_id"": ""MetaCyc:PWY0-1507"", ""source_assertion"": ""Native reaction-ordering places DETHIOBIOTIN-SYN-RXN before 2.8.1.6-RXN; the separately cited chemical sides identify the shared intermediate."", ""source_locator"": ""Pathway[@frameid='PWY0-1507']/reaction-ordering[Reaction/@frameid='2.8.1.6-RXN']/predecessor-reactions/Reaction[@frameid='DETHIOBIOTIN-SYN-RXN']""}, {""reference_id"": ""RHEA:15806"", ""source_assertion"": ""RHEA:15806 assigns CHEBI:149473 to products, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/15806 rh:products; http://rdf.rhea-db.org/15805_R rh:contains1 http://rdf.rhea-db.org/Participant_15805_compound_16404; rh:compound http://rdf.rhea-db.org/Compound_16404""}, {""reference_id"": ""RHEA:22061"", ""source_assertion"": ""RHEA:22061 assigns CHEBI:149473 to substrates, coefficient 1; generic polypeptide states remain whole carriers."", ""source_locator"": ""http://rdf.rhea-db.org/22061 rh:substrates; http://rdf.rhea-db.org/22060_L rh:contains1 http://rdf.rhea-db.org/Participant_22060_compound_16404; rh:compound http://rdf.rhea-db.org/Compound_16404""}]"	"[{""id"": ""MetaCyc:PWY0-1507"", ""source_sha256"": ""0c5cff1a8b72ef4ae2b75528d72de441b9876633e69e2aa75f20389402b9bd25"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PWY0-1507"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1507""}, {""id"": ""RHEA:15806"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 15806"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:22061"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples in edge locators"", ""title"": ""Rhea directed reaction 22061"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-101_a92192b4731b	MetaCyc:7KAPSYN-CPLX	BFO:0000051	UniProtKB:P12998	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:7KAPSYN-CPLX|MetaCyc:7KAPSYN-MONOMER	Native assembly stoichiometry; no claim that an isolated subunit is catalytically sufficient.	"[{""reference_id"": ""MetaCyc:7KAPSYN-CPLX"", ""source_assertion"": ""Native complex has 2 copies of 7KAPSYN-MONOMER; the species frame is E. coli MG1655."", ""source_locator"": ""Protein[@frameid='7KAPSYN-CPLX']/component; coefficient; species/Organism[@frameid='TAX-511145']""}, {""reference_id"": ""MetaCyc:7KAPSYN-MONOMER"", ""source_assertion"": ""Native subunit cross-reference identifies UniProtKB:P12998."", ""source_locator"": ""Protein[@frameid='7KAPSYN-MONOMER']/dblink[dblink-db='UNIPROT']""}]"	"[{""id"": ""MetaCyc:7KAPSYN-CPLX"", ""source_sha256"": ""5047e35aec6def6a2e8ef91580539b38d9e955b4ff3eddeceea8943c1d5f4b71"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""8-amino-7-oxononanoate synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:7KAPSYN-CPLX""}, {""id"": ""MetaCyc:7KAPSYN-MONOMER"", ""source_sha256"": ""a55198ea1395f4e54150930acc2c0a6955aa3953bec07ef7acee56ccee97ec31"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""7KAPSYN-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:7KAPSYN-MONOMER""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-102_483462ccffc9	MetaCyc:DAPASYN-CPLX	BFO:0000051	UniProtKB:P12995	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DAPASYN-CPLX|MetaCyc:DAPASYN-MONOMER	Native assembly stoichiometry; no claim that an isolated subunit is catalytically sufficient.	"[{""reference_id"": ""MetaCyc:DAPASYN-CPLX"", ""source_assertion"": ""Native complex has 2 copies of DAPASYN-MONOMER; the species frame is E. coli MG1655."", ""source_locator"": ""Protein[@frameid='DAPASYN-CPLX']/component; coefficient; species/Organism[@frameid='TAX-511145']""}, {""reference_id"": ""MetaCyc:DAPASYN-MONOMER"", ""source_assertion"": ""Native subunit cross-reference identifies UniProtKB:P12995."", ""source_locator"": ""Protein[@frameid='DAPASYN-MONOMER']/dblink[dblink-db='UNIPROT']""}]"	"[{""id"": ""MetaCyc:DAPASYN-CPLX"", ""source_sha256"": ""519e340c77701a40b67e22989123745709ffa025d021978531e1f908606e30f5"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""adenosylmethionine-8-amino-7-oxononanoate aminotransferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DAPASYN-CPLX""}, {""id"": ""MetaCyc:DAPASYN-MONOMER"", ""source_sha256"": ""fa85bff092d85408d26797d751473201057e14e839400e9dd971722131b03cc6"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""DAPASYN-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DAPASYN-MONOMER""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-103_b6ba64889149	MetaCyc:DETHIOBIOTIN-SYN-CPLX	BFO:0000051	UniProtKB:P13000	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DETHIOBIOTIN-SYN-CPLX|MetaCyc:DETHIOBIOTIN-SYN-MONOMER	Native assembly stoichiometry; no claim that an isolated subunit is catalytically sufficient.	"[{""reference_id"": ""MetaCyc:DETHIOBIOTIN-SYN-CPLX"", ""source_assertion"": ""Native complex has 2 copies of DETHIOBIOTIN-SYN-MONOMER; the species frame is E. coli MG1655."", ""source_locator"": ""Protein[@frameid='DETHIOBIOTIN-SYN-CPLX']/component; coefficient; species/Organism[@frameid='TAX-511145']""}, {""reference_id"": ""MetaCyc:DETHIOBIOTIN-SYN-MONOMER"", ""source_assertion"": ""Native subunit cross-reference identifies UniProtKB:P13000."", ""source_locator"": ""Protein[@frameid='DETHIOBIOTIN-SYN-MONOMER']/dblink[dblink-db='UNIPROT']""}]"	"[{""id"": ""MetaCyc:DETHIOBIOTIN-SYN-CPLX"", ""source_sha256"": ""79a97a1f2610ddc124859c40163e4d03f3c2340bc6177144eafff44db4050417"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""dethiobiotin synthetase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DETHIOBIOTIN-SYN-CPLX""}, {""id"": ""MetaCyc:DETHIOBIOTIN-SYN-MONOMER"", ""source_sha256"": ""9caa77c9f74f695ac8a056c3c9994e35f2e5999134b957b4de71f501f8e82489"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""DETHIOBIOTIN-SYN-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DETHIOBIOTIN-SYN-MONOMER""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-104_15a938529afc	MetaCyc:BIOTIN-SYN-CPLX	BFO:0000051	UniProtKB:P12996	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-SYN-CPLX|MetaCyc:BIOTIN-SYN-MONOMER	Native assembly stoichiometry; no claim that an isolated subunit is catalytically sufficient.	"[{""reference_id"": ""MetaCyc:BIOTIN-SYN-CPLX"", ""source_assertion"": ""Native complex has 2 copies of BIOTIN-SYN-MONOMER; the species frame is E. coli MG1655."", ""source_locator"": ""Protein[@frameid='BIOTIN-SYN-CPLX']/component; coefficient; species/Organism[@frameid='TAX-511145']""}, {""reference_id"": ""MetaCyc:BIOTIN-SYN-MONOMER"", ""source_assertion"": ""Native subunit cross-reference identifies UniProtKB:P12996."", ""source_locator"": ""Protein[@frameid='BIOTIN-SYN-MONOMER']/dblink[dblink-db='UNIPROT']""}]"	"[{""id"": ""MetaCyc:BIOTIN-SYN-CPLX"", ""source_sha256"": ""d61246f52ad07f583bc220cd6293328d6391034df5cc824bd6fab0ce39de7cc5"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""biotin synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-SYN-CPLX""}, {""id"": ""MetaCyc:BIOTIN-SYN-MONOMER"", ""source_sha256"": ""054ede04da46bfd468f6881179ce51b8fe347b8b6c7a4519c198bd993d136467"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""BIOTIN-SYN-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-SYN-MONOMER""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-105_a7fe61e250e6	MetaCyc:CPLX0-8005	BFO:0000051	UniProtKB:P0AEK2	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:3-OXOACYL-ACP-REDUCT-MONOMER|MetaCyc:CPLX0-8005	Native assembly stoichiometry; no claim that an isolated subunit is catalytically sufficient.	"[{""reference_id"": ""MetaCyc:CPLX0-8005"", ""source_assertion"": ""Native complex has 4 copies of 3-OXOACYL-ACP-REDUCT-MONOMER; the species frame is E. coli MG1655."", ""source_locator"": ""Protein[@frameid='CPLX0-8005']/component; coefficient; species/Organism[@frameid='TAX-511145']""}, {""reference_id"": ""MetaCyc:3-OXOACYL-ACP-REDUCT-MONOMER"", ""source_assertion"": ""Native subunit cross-reference identifies UniProtKB:P0AEK2."", ""source_locator"": ""Protein[@frameid='3-OXOACYL-ACP-REDUCT-MONOMER']/dblink[dblink-db='UNIPROT']""}]"	"[{""id"": ""MetaCyc:3-OXOACYL-ACP-REDUCT-MONOMER"", ""source_sha256"": ""ae56c2f56f5f72734c253d74b5d71b6980d4260d3eca5abaae67c478d8682342"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""3-OXOACYL-ACP-REDUCT-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:3-OXOACYL-ACP-REDUCT-MONOMER""}, {""id"": ""MetaCyc:CPLX0-8005"", ""source_sha256"": ""5365772b2ac77015c8a0fcedcda40e8afad903dd117ec2fb825e04cc3ada0cd3"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""3-oxoacyl-[acyl-carrier-protein] reductase FabG"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8005""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-106_aebbeb2eb8b0	MetaCyc:FABZ-CPLX	BFO:0000051	UniProtKB:P0A6Q6	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:FABZ-CPLX|MetaCyc:FABZ-MONOMER	Native assembly stoichiometry; no claim that an isolated subunit is catalytically sufficient. Hexamer assignment is based on E. coli His-tagged protein gel filtration, not the P. aeruginosa crystal as an E. coli measurement.	"[{""reference_id"": ""MetaCyc:FABZ-CPLX"", ""source_assertion"": ""Native complex has 6 copies of FABZ-MONOMER; the species frame is E. coli MG1655."", ""source_locator"": ""Protein[@frameid='FABZ-CPLX']/component; coefficient; species/Organism[@frameid='TAX-511145']""}, {""reference_id"": ""MetaCyc:FABZ-MONOMER"", ""source_assertion"": ""Native subunit cross-reference identifies UniProtKB:P0A6Q6."", ""source_locator"": ""Protein[@frameid='FABZ-MONOMER']/dblink[dblink-db='UNIPROT']""}]"	"[{""id"": ""MetaCyc:FABZ-CPLX"", ""source_sha256"": ""cb9a96d47cd28b82ae5695cf5d4a581b24e51bf24fe8908539f7332470fc05e4"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""3-hydroxy-acyl-[acyl-carrier-protein] dehydratase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:FABZ-CPLX""}, {""id"": ""MetaCyc:FABZ-MONOMER"", ""source_sha256"": ""ff9538e2608fdd25883b194622695d4d955729ca7718aa6b26566541cc0d8e82"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""FABZ-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:FABZ-MONOMER""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-107_430596dfc648	MetaCyc:CPLX0-8006	BFO:0000051	UniProtKB:P0AEK4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8006|MetaCyc:ENOYL-ACP-REDUCT-NADH-MONOMER	Native assembly stoichiometry; no claim that an isolated subunit is catalytically sufficient.	"[{""reference_id"": ""MetaCyc:CPLX0-8006"", ""source_assertion"": ""Native complex has 4 copies of ENOYL-ACP-REDUCT-NADH-MONOMER; the species frame is E. coli MG1655."", ""source_locator"": ""Protein[@frameid='CPLX0-8006']/component; coefficient; species/Organism[@frameid='TAX-511145']""}, {""reference_id"": ""MetaCyc:ENOYL-ACP-REDUCT-NADH-MONOMER"", ""source_assertion"": ""Native subunit cross-reference identifies UniProtKB:P0AEK4."", ""source_locator"": ""Protein[@frameid='ENOYL-ACP-REDUCT-NADH-MONOMER']/dblink[dblink-db='UNIPROT']""}]"	"[{""id"": ""MetaCyc:CPLX0-8006"", ""source_sha256"": ""3ec15c277d99b655442fb97a39ee955e225954faa841e501d688863d8fc074c5"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""enoyl-[acyl-carrier-protein] reductase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8006""}, {""id"": ""MetaCyc:ENOYL-ACP-REDUCT-NADH-MONOMER"", ""source_sha256"": ""f4a8b0fe9ebc02ef92d22a0e7c763d08e6d1a5fc635b0c298e9b7d4c0b1f1dae"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ENOYL-ACP-REDUCT-NADH-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENOYL-ACP-REDUCT-NADH-MONOMER""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-108_2d257f7823ef	MetaCyc:FABB-CPLX	BFO:0000051	UniProtKB:P0A953	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:FABB-CPLX|MetaCyc:FABB-MONOMER	Native assembly stoichiometry; no claim that an isolated subunit is catalytically sufficient.	"[{""reference_id"": ""MetaCyc:FABB-CPLX"", ""source_assertion"": ""Native complex has 2 copies of FABB-MONOMER; the species frame is E. coli MG1655."", ""source_locator"": ""Protein[@frameid='FABB-CPLX']/component; coefficient; species/Organism[@frameid='TAX-511145']""}, {""reference_id"": ""MetaCyc:FABB-MONOMER"", ""source_assertion"": ""Native subunit cross-reference identifies UniProtKB:P0A953."", ""source_locator"": ""Protein[@frameid='FABB-MONOMER']/dblink[dblink-db='UNIPROT']""}]"	"[{""id"": ""MetaCyc:FABB-CPLX"", ""source_sha256"": ""807e526a311ae772957636673d969e9672a9ffdbff85e0d7ab757f64ca0ac58b"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""beta-ketoacyl-[acyl carrier protein] synthase I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:FABB-CPLX""}, {""id"": ""MetaCyc:FABB-MONOMER"", ""source_sha256"": ""a3340d0136b8510de92a1c38429c7577693af7aa4894dbe21643fde5c3294cdf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""FABB-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:FABB-MONOMER""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-109_1f230959bd32	UniProtKB:P12999	pathwaymech:enables	RHEA:17106	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:EG10119-MONOMER|MetaCyc:ENZRXN-17863|PMID:22965231|UniProtKB:P12999	E. coli BioC supports the route genetically and in a weak refolded coupled assay. Direct purified malonyl-ACP methyltransferase experiments used B. cereus BioC; those data do not establish an E. coli oligomer.	"[{""reference_id"": ""MetaCyc:ENZRXN-17863"", ""source_assertion"": ""Native enzymatic-reaction connects EG10119-MONOMER to RXN-11475. The biotin-specific FAS/BioC assignment is indirect where its native evidence is EV-EXP-IMP or reaction-blocked."", ""source_locator"": ""Enzymatic-Reaction[@frameid='ENZRXN-17863']/enzyme; reaction; citation""}, {""reference_id"": ""MetaCyc:EG10119-MONOMER"", ""source_assertion"": ""Native protein cross-reference identifies UniProtKB:P12999."", ""source_locator"": ""Protein[@frameid='EG10119-MONOMER']/dblink[dblink-db='UNIPROT']""}, {""reference_id"": ""UniProtKB:P12999"", ""source_assertion"": ""Current reviewed catalytic-activity annotation links P12999 to RHEA:17105; exact directed chemistry is separately grounded in Rhea 142. Annotation evidence codes remain in the protein source projection."", ""source_locator"": ""results[primaryAccession='P12999'].comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}, {""reference_id"": ""PMID:22965231"", ""source_assertion"": ""Purified B. cereus BioC complemented E. coli bioC and favored malonyl-ACP over malonyl-CoA. Active E. coli BioC purification remained problematic; the direct enzyme assay was not on the E. coli protein."", ""source_locator"": ""Abstract; Results, paragraph beginning We tested malonyl-ACP and malonyl-CoA""}]"	"[{""id"": ""MetaCyc:EG10119-MONOMER"", ""source_sha256"": ""0fde3d40fab33a22baca4a27db5e067cad096103ee836d196bf6c346928a96a8"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""EG10119-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:EG10119-MONOMER""}, {""id"": ""MetaCyc:ENZRXN-17863"", ""source_sha256"": ""f69a0da1fe260865cb863bf9effa36a376a095179d6804ab4f5496e697ee319e"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ENZRXN-17863"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-17863""}, {""id"": ""PMID:22965231"", ""source_sha256"": ""3a0520b72a5c655656e7d7d8433e1e49a40d0f11ce133af006f416ebc68ba378"", ""source_version"": ""Primary full article HTML retrieved 2026-10-11 UTC; inspected cited sections; digest covers entire retained HTML."", ""title"": ""The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin synthesis."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3481302/""}, {""id"": ""UniProtKB:P12999"", ""source_sha256"": ""45662ff7628d87bc987c1edfaa2d7bc5833866c44c4f275df5561cfe0aae392f"", ""source_version"": ""UniProt 2026_03 (2026-09-02); complete JSON retrieved 2026-10-11 UTC. Digest covers the whole retained response; accession-specific comments are selected by source locators."", ""title"": ""Malonyl-[acyl-carrier protein] O-methyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A83333%29%20AND%20%28gene_exact%3AbioC%20OR%20gene_exact%3AbioH%20OR%20gene_exact%3AbioF%20OR%20gene_exact%3AbioA%20OR%20gene_exact%3AbioD%20OR%20gene_exact%3AbioB%29&format=json""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-110_5ec10c0cffc8	MetaCyc:CPLX0-8005	pathwaymech:enables	MetaCyc:RXN-11476	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-17867|UniProtKB:P0AEK2	Source-supported functional role, not a purified-substrate assay or isolated-subunit sufficiency claim. Native FAS assignments are supported by pathway genetics/inhibition and general enzyme specificity.	"[{""reference_id"": ""MetaCyc:ENZRXN-17867"", ""source_assertion"": ""Native enzymatic-reaction connects CPLX0-8005 to RXN-11476. The biotin-specific FAS/BioC assignment is indirect where its native evidence is EV-EXP-IMP or reaction-blocked."", ""source_locator"": ""Enzymatic-Reaction[@frameid='ENZRXN-17867']/enzyme; reaction; citation""}, {""reference_id"": ""UniProtKB:P0AEK2"", ""source_assertion"": ""Reviewed FUNCTION annotation describes the protein fatty-acid synthesis activity (ECO:0000269). It does not by itself establish the exact biotin methyl-ester substrate; that assignment is separately sourced to MetaCyc."", ""source_locator"": ""results[primaryAccession='P0AEK2'].comments[commentType='FUNCTION']""}]"	"[{""id"": ""MetaCyc:ENZRXN-17867"", ""source_sha256"": ""5982ee55d17ce63427889594a056b49aa055bae24c0bf79eb43030358ed5e032"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ENZRXN-17867"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-17867""}, {""id"": ""UniProtKB:P0AEK2"", ""source_sha256"": ""ee4300e4e8189f731c76d1baeae36e49e03c09b6bc4a9b283fe778ceb6427de3"", ""source_version"": ""UniProt 2026_03 (2026-09-02); complete JSON retrieved 2026-10-11 UTC. Digest covers the whole retained response; accession-specific comments are selected by source locators."", ""title"": ""3-oxoacyl-[acyl-carrier-protein] reductase FabG"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A83333%29%20AND%20%28gene_exact%3AfabB%20OR%20gene_exact%3AfabF%20OR%20gene_exact%3AfabG%20OR%20gene_exact%3AfabZ%20OR%20gene_exact%3AfabI%20OR%20gene_exact%3AacpP%29&format=json""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-111_7e535259ee11	MetaCyc:FABZ-CPLX	pathwaymech:enables	MetaCyc:RXN-11477	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-17869|UniProtKB:P0A6Q6	Source-supported functional role, not a purified-substrate assay or isolated-subunit sufficiency claim. Native FAS assignments are supported by pathway genetics/inhibition and general enzyme specificity.	"[{""reference_id"": ""MetaCyc:ENZRXN-17869"", ""source_assertion"": ""Native enzymatic-reaction connects FABZ-CPLX to RXN-11477. The biotin-specific FAS/BioC assignment is indirect where its native evidence is EV-EXP-IMP or reaction-blocked."", ""source_locator"": ""Enzymatic-Reaction[@frameid='ENZRXN-17869']/enzyme; reaction; citation""}, {""reference_id"": ""UniProtKB:P0A6Q6"", ""source_assertion"": ""Reviewed FUNCTION annotation describes the protein fatty-acid synthesis activity (ECO:0000269). It does not by itself establish the exact biotin methyl-ester substrate; that assignment is separately sourced to MetaCyc."", ""source_locator"": ""results[primaryAccession='P0A6Q6'].comments[commentType='FUNCTION']""}]"	"[{""id"": ""MetaCyc:ENZRXN-17869"", ""source_sha256"": ""e24e38ff4466e57196992f702c54b8c524139ec28829d9ed3512f892733cf8ae"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ENZRXN-17869"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-17869""}, {""id"": ""UniProtKB:P0A6Q6"", ""source_sha256"": ""ee4300e4e8189f731c76d1baeae36e49e03c09b6bc4a9b283fe778ceb6427de3"", ""source_version"": ""UniProt 2026_03 (2026-09-02); complete JSON retrieved 2026-10-11 UTC. Digest covers the whole retained response; accession-specific comments are selected by source locators."", ""title"": ""3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A83333%29%20AND%20%28gene_exact%3AfabB%20OR%20gene_exact%3AfabF%20OR%20gene_exact%3AfabG%20OR%20gene_exact%3AfabZ%20OR%20gene_exact%3AfabI%20OR%20gene_exact%3AacpP%29&format=json""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-112_73e8437182a5	MetaCyc:CPLX0-8006	pathwaymech:enables	MetaCyc:RXN-11478	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-17871|UniProtKB:P0AEK4	Source-supported functional role, not a purified-substrate assay or isolated-subunit sufficiency claim. Native FAS assignments are supported by pathway genetics/inhibition and general enzyme specificity.	"[{""reference_id"": ""MetaCyc:ENZRXN-17871"", ""source_assertion"": ""Native enzymatic-reaction connects CPLX0-8006 to RXN-11478. The biotin-specific FAS/BioC assignment is indirect where its native evidence is EV-EXP-IMP or reaction-blocked."", ""source_locator"": ""Enzymatic-Reaction[@frameid='ENZRXN-17871']/enzyme; reaction; citation""}, {""reference_id"": ""UniProtKB:P0AEK4"", ""source_assertion"": ""Reviewed FUNCTION annotation describes the protein fatty-acid synthesis activity (ECO:0000269). It does not by itself establish the exact biotin methyl-ester substrate; that assignment is separately sourced to MetaCyc."", ""source_locator"": ""results[primaryAccession='P0AEK4'].comments[commentType='FUNCTION']""}]"	"[{""id"": ""MetaCyc:ENZRXN-17871"", ""source_sha256"": ""10350518b72a6edab3f90decde11da75d7e47af91424a379b9fd0cef646d9293"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ENZRXN-17871"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-17871""}, {""id"": ""UniProtKB:P0AEK4"", ""source_sha256"": ""ee4300e4e8189f731c76d1baeae36e49e03c09b6bc4a9b283fe778ceb6427de3"", ""source_version"": ""UniProt 2026_03 (2026-09-02); complete JSON retrieved 2026-10-11 UTC. Digest covers the whole retained response; accession-specific comments are selected by source locators."", ""title"": ""Enoyl-[acyl-carrier-protein] reductase [NADH] FabI"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A83333%29%20AND%20%28gene_exact%3AfabB%20OR%20gene_exact%3AfabF%20OR%20gene_exact%3AfabG%20OR%20gene_exact%3AfabZ%20OR%20gene_exact%3AfabI%20OR%20gene_exact%3AacpP%29&format=json""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-113_018375b61967	MetaCyc:FABB-CPLX	pathwaymech:enables	MetaCyc:RXN-11479	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-17873|UniProtKB:P0A953	Source-supported functional role, not a purified-substrate assay or isolated-subunit sufficiency claim. Native FAS assignments are supported by pathway genetics/inhibition and general enzyme specificity.	"[{""reference_id"": ""MetaCyc:ENZRXN-17873"", ""source_assertion"": ""Native enzymatic-reaction connects FABB-CPLX to RXN-11479. The biotin-specific FAS/BioC assignment is indirect where its native evidence is EV-EXP-IMP or reaction-blocked."", ""source_locator"": ""Enzymatic-Reaction[@frameid='ENZRXN-17873']/enzyme; reaction; citation""}, {""reference_id"": ""UniProtKB:P0A953"", ""source_assertion"": ""Reviewed FUNCTION annotation describes the protein fatty-acid synthesis activity (ECO:0000269). It does not by itself establish the exact biotin methyl-ester substrate; that assignment is separately sourced to MetaCyc."", ""source_locator"": ""results[primaryAccession='P0A953'].comments[commentType='FUNCTION']""}]"	"[{""id"": ""MetaCyc:ENZRXN-17873"", ""source_sha256"": ""6e82a54cd5aff4d60bc162a8ed45b0a9e022af5642e2e039dc0337dd45296b03"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ENZRXN-17873"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-17873""}, {""id"": ""UniProtKB:P0A953"", ""source_sha256"": ""ee4300e4e8189f731c76d1baeae36e49e03c09b6bc4a9b283fe778ceb6427de3"", ""source_version"": ""UniProt 2026_03 (2026-09-02); complete JSON retrieved 2026-10-11 UTC. Digest covers the whole retained response; accession-specific comments are selected by source locators."", ""title"": ""3-oxoacyl-[acyl-carrier-protein] synthase 1"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A83333%29%20AND%20%28gene_exact%3AfabB%20OR%20gene_exact%3AfabF%20OR%20gene_exact%3AfabG%20OR%20gene_exact%3AfabZ%20OR%20gene_exact%3AfabI%20OR%20gene_exact%3AacpP%29&format=json""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-114_ecef46e85517	MetaCyc:CPLX0-8005	pathwaymech:enables	MetaCyc:RXN-11480	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-17868|UniProtKB:P0AEK2	Source-supported functional role, not a purified-substrate assay or isolated-subunit sufficiency claim. Native FAS assignments are supported by pathway genetics/inhibition and general enzyme specificity.	"[{""reference_id"": ""MetaCyc:ENZRXN-17868"", ""source_assertion"": ""Native enzymatic-reaction connects CPLX0-8005 to RXN-11480. The biotin-specific FAS/BioC assignment is indirect where its native evidence is EV-EXP-IMP or reaction-blocked."", ""source_locator"": ""Enzymatic-Reaction[@frameid='ENZRXN-17868']/enzyme; reaction; citation""}, {""reference_id"": ""UniProtKB:P0AEK2"", ""source_assertion"": ""Reviewed FUNCTION annotation describes the protein fatty-acid synthesis activity (ECO:0000269). It does not by itself establish the exact biotin methyl-ester substrate; that assignment is separately sourced to MetaCyc."", ""source_locator"": ""results[primaryAccession='P0AEK2'].comments[commentType='FUNCTION']""}]"	"[{""id"": ""MetaCyc:ENZRXN-17868"", ""source_sha256"": ""c8ea8cf0defe42a337b45c72ba9c337c690221e3da9d6e5b73f6f594c5812035"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ENZRXN-17868"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-17868""}, {""id"": ""UniProtKB:P0AEK2"", ""source_sha256"": ""ee4300e4e8189f731c76d1baeae36e49e03c09b6bc4a9b283fe778ceb6427de3"", ""source_version"": ""UniProt 2026_03 (2026-09-02); complete JSON retrieved 2026-10-11 UTC. Digest covers the whole retained response; accession-specific comments are selected by source locators."", ""title"": ""3-oxoacyl-[acyl-carrier-protein] reductase FabG"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A83333%29%20AND%20%28gene_exact%3AfabB%20OR%20gene_exact%3AfabF%20OR%20gene_exact%3AfabG%20OR%20gene_exact%3AfabZ%20OR%20gene_exact%3AfabI%20OR%20gene_exact%3AacpP%29&format=json""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-115_816038c3d1ac	MetaCyc:FABZ-CPLX	pathwaymech:enables	MetaCyc:RXN-11481	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-17870|UniProtKB:P0A6Q6	Source-supported functional role, not a purified-substrate assay or isolated-subunit sufficiency claim. Native FAS assignments are supported by pathway genetics/inhibition and general enzyme specificity.	"[{""reference_id"": ""MetaCyc:ENZRXN-17870"", ""source_assertion"": ""Native enzymatic-reaction connects FABZ-CPLX to RXN-11481. The biotin-specific FAS/BioC assignment is indirect where its native evidence is EV-EXP-IMP or reaction-blocked."", ""source_locator"": ""Enzymatic-Reaction[@frameid='ENZRXN-17870']/enzyme; reaction; citation""}, {""reference_id"": ""UniProtKB:P0A6Q6"", ""source_assertion"": ""Reviewed FUNCTION annotation describes the protein fatty-acid synthesis activity (ECO:0000269). It does not by itself establish the exact biotin methyl-ester substrate; that assignment is separately sourced to MetaCyc."", ""source_locator"": ""results[primaryAccession='P0A6Q6'].comments[commentType='FUNCTION']""}]"	"[{""id"": ""MetaCyc:ENZRXN-17870"", ""source_sha256"": ""83715bac7f2cd9adcfd84f87ef85ee9016b3b53b9bef3f38ad528f4317723d2d"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ENZRXN-17870"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-17870""}, {""id"": ""UniProtKB:P0A6Q6"", ""source_sha256"": ""ee4300e4e8189f731c76d1baeae36e49e03c09b6bc4a9b283fe778ceb6427de3"", ""source_version"": ""UniProt 2026_03 (2026-09-02); complete JSON retrieved 2026-10-11 UTC. Digest covers the whole retained response; accession-specific comments are selected by source locators."", ""title"": ""3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A83333%29%20AND%20%28gene_exact%3AfabB%20OR%20gene_exact%3AfabF%20OR%20gene_exact%3AfabG%20OR%20gene_exact%3AfabZ%20OR%20gene_exact%3AfabI%20OR%20gene_exact%3AacpP%29&format=json""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-116_ad18ae1d5343	MetaCyc:CPLX0-8006	pathwaymech:enables	MetaCyc:RXN-11482	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-17872|UniProtKB:P0AEK4	Source-supported functional role, not a purified-substrate assay or isolated-subunit sufficiency claim. Native FAS assignments are supported by pathway genetics/inhibition and general enzyme specificity.	"[{""reference_id"": ""MetaCyc:ENZRXN-17872"", ""source_assertion"": ""Native enzymatic-reaction connects CPLX0-8006 to RXN-11482. The biotin-specific FAS/BioC assignment is indirect where its native evidence is EV-EXP-IMP or reaction-blocked."", ""source_locator"": ""Enzymatic-Reaction[@frameid='ENZRXN-17872']/enzyme; reaction; citation""}, {""reference_id"": ""UniProtKB:P0AEK4"", ""source_assertion"": ""Reviewed FUNCTION annotation describes the protein fatty-acid synthesis activity (ECO:0000269). It does not by itself establish the exact biotin methyl-ester substrate; that assignment is separately sourced to MetaCyc."", ""source_locator"": ""results[primaryAccession='P0AEK4'].comments[commentType='FUNCTION']""}]"	"[{""id"": ""MetaCyc:ENZRXN-17872"", ""source_sha256"": ""d901ffbacd11320335f76f4d63f31e6d06a3e9f28e57427d22abd067ba365a95"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ENZRXN-17872"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-17872""}, {""id"": ""UniProtKB:P0AEK4"", ""source_sha256"": ""ee4300e4e8189f731c76d1baeae36e49e03c09b6bc4a9b283fe778ceb6427de3"", ""source_version"": ""UniProt 2026_03 (2026-09-02); complete JSON retrieved 2026-10-11 UTC. Digest covers the whole retained response; accession-specific comments are selected by source locators."", ""title"": ""Enoyl-[acyl-carrier-protein] reductase [NADH] FabI"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A83333%29%20AND%20%28gene_exact%3AfabB%20OR%20gene_exact%3AfabF%20OR%20gene_exact%3AfabG%20OR%20gene_exact%3AfabZ%20OR%20gene_exact%3AfabI%20OR%20gene_exact%3AacpP%29&format=json""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-117_293fd0bdbf64	UniProtKB:P13001	pathwaymech:catalyzes	RHEA:42701	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:EG10122-MONOMER|MetaCyc:ENZRXN-17864|PMID:23045647|UniProtKB:P13001		"[{""reference_id"": ""MetaCyc:ENZRXN-17864"", ""source_assertion"": ""Native enzymatic-reaction connects EG10122-MONOMER to RXN-11483. The biotin-specific FAS/BioC assignment is indirect where its native evidence is EV-EXP-IMP or reaction-blocked."", ""source_locator"": ""Enzymatic-Reaction[@frameid='ENZRXN-17864']/enzyme; reaction; citation""}, {""reference_id"": ""MetaCyc:EG10122-MONOMER"", ""source_assertion"": ""Native protein cross-reference identifies UniProtKB:P13001."", ""source_locator"": ""Protein[@frameid='EG10122-MONOMER']/dblink[dblink-db='UNIPROT']""}, {""reference_id"": ""UniProtKB:P13001"", ""source_assertion"": ""Current reviewed catalytic-activity annotation links P13001 to RHEA:42700; exact directed chemistry is separately grounded in Rhea 142. Annotation evidence codes remain in the protein source projection."", ""source_locator"": ""results[primaryAccession='P13001'].comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}, {""reference_id"": ""PMID:23045647"", ""source_assertion"": ""BioH S82A was crystallized with pimeloyl-ACP methyl ester; biochemical mutagenesis and E. coli complementation establish the native BioH gatekeeper substrate. The trapped enzyme-substrate complex is not a permanent oligomer."", ""source_locator"": ""Abstract; Results, BioH:ACP Interactions; Discussion""}]"	"[{""id"": ""MetaCyc:EG10122-MONOMER"", ""source_sha256"": ""8bead6687fc80cccaf12d4feeae704da3498e30595f825bcd9ed9f5aea03a7fc"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""EG10122-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:EG10122-MONOMER""}, {""id"": ""MetaCyc:ENZRXN-17864"", ""source_sha256"": ""3dbf5ab8479840834b7f99cef92d57d80998a293688384973b55c03b97ba971b"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ENZRXN-17864"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-17864""}, {""id"": ""PMID:23045647"", ""source_sha256"": ""9a9113c35673e98077ebbc8def8ba67926f54a03cad615191c02fed6bbe3dc93"", ""source_version"": ""Primary full article HTML retrieved 2026-10-11 UTC; inspected cited sections; digest covers entire retained HTML."", ""title"": ""Structure of the enzyme-acyl carrier protein (ACP) substrate gatekeeper complex required for biotin synthesis."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3491474/""}, {""id"": ""UniProtKB:P13001"", ""source_sha256"": ""45662ff7628d87bc987c1edfaa2d7bc5833866c44c4f275df5561cfe0aae392f"", ""source_version"": ""UniProt 2026_03 (2026-09-02); complete JSON retrieved 2026-10-11 UTC. Digest covers the whole retained response; accession-specific comments are selected by source locators."", ""title"": ""Pimeloyl-[acyl-carrier protein] methyl ester esterase"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A83333%29%20AND%20%28gene_exact%3AbioC%20OR%20gene_exact%3AbioH%20OR%20gene_exact%3AbioF%20OR%20gene_exact%3AbioA%20OR%20gene_exact%3AbioD%20OR%20gene_exact%3AbioB%29&format=json""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-118_3adb1bd46d46	MetaCyc:7KAPSYN-CPLX	pathwaymech:catalyzes	RHEA:42289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-17865|PMID:10642176|PMID:20693992|UniProtKB:P12998		"[{""reference_id"": ""MetaCyc:ENZRXN-17865"", ""source_assertion"": ""Native enzymatic-reaction connects 7KAPSYN-CPLX to RXN-11484. The biotin-specific FAS/BioC assignment is indirect where its native evidence is EV-EXP-IMP or reaction-blocked."", ""source_locator"": ""Enzymatic-Reaction[@frameid='ENZRXN-17865']/enzyme; reaction; citation""}, {""reference_id"": ""UniProtKB:P12998"", ""source_assertion"": ""Current reviewed catalytic-activity annotation links P12998 to RHEA:42288; exact directed chemistry is separately grounded in Rhea 142. Annotation evidence codes remain in the protein source projection."", ""source_locator"": ""results[primaryAccession='P12998'].comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}, {""reference_id"": ""PMID:20693992"", ""source_assertion"": ""E. coli growth bypass with AasS plus monomethyl pimelate or BioW plus pimelate argues that BioF accepts ACP and CoA thioesters. This is not purified BioF substrate kinetics; the native ACP-specific evidence is unpurified/coupled."", ""source_locator"": ""Results, paragraph P6; Supplementary Fig. 3 as discussed in main text (supplement not independently inspected)""}, {""reference_id"": ""PMID:10642176"", ""source_assertion"": ""E. coli AONS is PLP-dependent and forms the 8(S) product from L-alanine and pimeloyl-CoA; this older kinetic study does not directly prove ACP-substrate kinetics."", ""source_locator"": ""Indexed abstract""}]"	"[{""id"": ""MetaCyc:ENZRXN-17865"", ""source_sha256"": ""ba1efb7bfadc6fa3d3b1d1377fcef3e2d427bc7b5f317891cc36ba5c7a1477fc"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""ENZRXN-17865"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-17865""}, {""id"": ""PMID:10642176"", ""source_sha256"": ""b737a4dd08a4a3b8492b324ab43f11dd3736b79b48b7268a21c2177c45a585ee"", ""source_version"": ""Primary indexed abstract inspected in Europe PMC core JSON, not full article; digest covers entire 20-PMID response retrieved 2026-10-11 UTC."", ""title"": ""Mechanism of 8-amino-7-oxononanoate synthase: spectroscopic, kinetic, and crystallographic studies."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/10642176/""}, {""id"": ""PMID:20693992"", ""source_sha256"": ""27f4472bbabbc739ba0049707647ed5a53ac060c207e3b2c71f5a927d3ea490c"", ""source_version"": ""Primary full article HTML retrieved 2026-10-11 UTC; inspected cited sections; digest covers entire retained HTML."", ""title"": ""Biotin synthesis begins by hijacking the fatty acid synthetic pathway."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2925990/""}, {""id"": ""UniProtKB:P12998"", ""source_sha256"": ""45662ff7628d87bc987c1edfaa2d7bc5833866c44c4f275df5561cfe0aae392f"", ""source_version"": ""UniProt 2026_03 (2026-09-02); complete JSON retrieved 2026-10-11 UTC. Digest covers the whole retained response; accession-specific comments are selected by source locators."", ""title"": ""8-amino-7-oxononanoate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A83333%29%20AND%20%28gene_exact%3AbioC%20OR%20gene_exact%3AbioH%20OR%20gene_exact%3AbioF%20OR%20gene_exact%3AbioA%20OR%20gene_exact%3AbioD%20OR%20gene_exact%3AbioB%29&format=json""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-119_ae1f0b0023fc	MetaCyc:DAPASYN-CPLX	pathwaymech:catalyzes	RHEA:16862	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DAPASYN-ENZRXN|PMID:1092681|UniProtKB:P12995		"[{""reference_id"": ""MetaCyc:DAPASYN-ENZRXN"", ""source_assertion"": ""Native enzymatic-reaction connects DAPASYN-CPLX to DAPASYN-RXN. The biotin-specific FAS/BioC assignment is indirect where its native evidence is EV-EXP-IMP or reaction-blocked."", ""source_locator"": ""Enzymatic-Reaction[@frameid='DAPASYN-ENZRXN']/enzyme; reaction; citation""}, {""reference_id"": ""UniProtKB:P12995"", ""source_assertion"": ""Current reviewed catalytic-activity annotation links P12995 to RHEA:16861; exact directed chemistry is separately grounded in Rhea 142. Annotation evidence codes remain in the protein source projection."", ""source_locator"": ""results[primaryAccession='P12995'].comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}, {""reference_id"": ""PMID:1092681"", ""source_assertion"": ""The E. coli aminotransferase uses SAM as amino donor, has a PLP cofactor and an estimated 94 kDa dimer of 47 kDa subunits; the preparation was estimated 86% homogeneous."", ""source_locator"": ""Indexed abstract""}]"	"[{""id"": ""MetaCyc:DAPASYN-ENZRXN"", ""source_sha256"": ""396c571bd4611d5e32765b4f7181a8213f5b33e0269193c459c8270cb77b0091"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""DAPASYN-ENZRXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DAPASYN-ENZRXN""}, {""id"": ""PMID:1092681"", ""source_sha256"": ""b737a4dd08a4a3b8492b324ab43f11dd3736b79b48b7268a21c2177c45a585ee"", ""source_version"": ""Primary indexed abstract inspected in Europe PMC core JSON, not full article; digest covers entire 20-PMID response retrieved 2026-10-11 UTC."", ""title"": ""Purification and properties of 7, 8-diaminopelargonic acid aminotransferase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/1092681/""}, {""id"": ""UniProtKB:P12995"", ""source_sha256"": ""45662ff7628d87bc987c1edfaa2d7bc5833866c44c4f275df5561cfe0aae392f"", ""source_version"": ""UniProt 2026_03 (2026-09-02); complete JSON retrieved 2026-10-11 UTC. Digest covers the whole retained response; accession-specific comments are selected by source locators."", ""title"": ""Adenosylmethionine-8-amino-7-oxononanoate aminotransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A83333%29%20AND%20%28gene_exact%3AbioC%20OR%20gene_exact%3AbioH%20OR%20gene_exact%3AbioF%20OR%20gene_exact%3AbioA%20OR%20gene_exact%3AbioD%20OR%20gene_exact%3AbioB%29&format=json""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-120_92e361354fc5	MetaCyc:DETHIOBIOTIN-SYN-CPLX	pathwaymech:catalyzes	RHEA:15806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DETHIOBIOTIN-SYN-ENZRXN|PMID:7669755|UniProtKB:P13000		"[{""reference_id"": ""MetaCyc:DETHIOBIOTIN-SYN-ENZRXN"", ""source_assertion"": ""Native enzymatic-reaction connects DETHIOBIOTIN-SYN-CPLX to DETHIOBIOTIN-SYN-RXN. The biotin-specific FAS/BioC assignment is indirect where its native evidence is EV-EXP-IMP or reaction-blocked."", ""source_locator"": ""Enzymatic-Reaction[@frameid='DETHIOBIOTIN-SYN-ENZRXN']/enzyme; reaction; citation""}, {""reference_id"": ""UniProtKB:P13000"", ""source_assertion"": ""Current reviewed catalytic-activity annotation links P13000 to RHEA:15805; exact directed chemistry is separately grounded in Rhea 142. Annotation evidence codes remain in the protein source projection."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}, {""reference_id"": ""PMID:7669755"", ""source_assertion"": ""Only the N7-carbamate of (7R,8S)-diaminononanoate is the cyclization intermediate; commitment occurs upon MgATP addition. CO2 is the net Rhea substrate, not a separately inserted bicarbonate reaction."", ""source_locator"": ""Indexed abstract (publisher abstract is truncated)""}]"	"[{""id"": ""MetaCyc:DETHIOBIOTIN-SYN-ENZRXN"", ""source_sha256"": ""75d5cb7d9d243c462944b4d14570a5598c57ee94b7f0649a2de1be9f7ccc2c31"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""DETHIOBIOTIN-SYN-ENZRXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DETHIOBIOTIN-SYN-ENZRXN""}, {""id"": ""PMID:7669755"", ""source_sha256"": ""b737a4dd08a4a3b8492b324ab43f11dd3736b79b48b7268a21c2177c45a585ee"", ""source_version"": ""Primary indexed abstract inspected in Europe PMC core JSON, not full article; digest covers entire 20-PMID response retrieved 2026-10-11 UTC."", ""title"": ""Dethiobiotin synthetase: the carbonylation of 7,8-diaminonanoic acid proceeds regiospecifically via the N7-carbamate."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/7669755/""}, {""id"": ""UniProtKB:P13000"", ""source_sha256"": ""68998b083d250ab32f19afadb25be61bab48b48750590a03c5c84dabd5174a3a"", ""source_version"": ""UniProt 2026_03 (2026-09-02); complete JSON retrieved 2026-10-11 UTC. Digest covers the whole retained response; accession-specific comments are selected by source locators."", ""title"": ""ATP-dependent dethiobiotin synthetase BioD 1"", ""url"": ""https://rest.uniprot.org/uniprotkb/P13000.json""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-121_ed307a35f1b3	MetaCyc:BIOTIN-SYN-CPLX	pathwaymech:catalyzes	RHEA:22061	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-SYN-ENZRXN|PMID:20961145|UniProtKB:P12996	Formal Rhea net chemistry retains generic sulfur-carrier and ferredoxin states. E. coli BioB assays use flavodoxin/reductase/NADPH; no specific ferredoxin identity or entire cluster-repair mechanism is asserted.	"[{""reference_id"": ""MetaCyc:BIOTIN-SYN-ENZRXN"", ""source_assertion"": ""Native enzymatic-reaction connects BIOTIN-SYN-CPLX to 2.8.1.6-RXN. The biotin-specific FAS/BioC assignment is indirect where its native evidence is EV-EXP-IMP or reaction-blocked."", ""source_locator"": ""Enzymatic-Reaction[@frameid='BIOTIN-SYN-ENZRXN']/enzyme; reaction; citation""}, {""reference_id"": ""UniProtKB:P12996"", ""source_assertion"": ""Current reviewed catalytic-activity annotation links P12996 to RHEA:22060; exact directed chemistry is separately grounded in Rhea 142. Annotation evidence codes remain in the protein source projection."", ""source_locator"": ""results[primaryAccession='P12996'].comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}, {""reference_id"": ""PMID:20961145"", ""source_assertion"": ""Optimized anaerobic assays with purified SAM and MTAN relieve product inhibition and show multiple BioB turnovers. The electron-transfer assay uses flavodoxin, ferredoxin/flavodoxin-NADP reductase and NADPH."", ""source_locator"": ""Methods, Biotin Synthase Activity Assay, P9; Results/Discussion on multiple turnovers""}]"	"[{""id"": ""MetaCyc:BIOTIN-SYN-ENZRXN"", ""source_sha256"": ""afa7d9de110b7e8841cd8d51ea35d1d2e42b389c17c6e0cf46a0ef10cb10f2c2"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""BIOTIN-SYN-ENZRXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-SYN-ENZRXN""}, {""id"": ""PMID:20961145"", ""source_sha256"": ""0b356a3ed1eb5a0210d00d4e0a822d4c722384c101d6dec03daf3ef2ca494182"", ""source_version"": ""Primary full article HTML retrieved 2026-10-11 UTC; inspected cited sections; digest covers entire retained HTML."", ""title"": ""Biotin synthase exhibits burst kinetics and multiple turnovers in the absence of inhibition by products and product-related biomolecules."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC6541390/""}, {""id"": ""UniProtKB:P12996"", ""source_sha256"": ""45662ff7628d87bc987c1edfaa2d7bc5833866c44c4f275df5561cfe0aae392f"", ""source_version"": ""UniProt 2026_03 (2026-09-02); complete JSON retrieved 2026-10-11 UTC. Digest covers the whole retained response; accession-specific comments are selected by source locators."", ""title"": ""Biotin synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A83333%29%20AND%20%28gene_exact%3AbioC%20OR%20gene_exact%3AbioH%20OR%20gene_exact%3AbioF%20OR%20gene_exact%3AbioA%20OR%20gene_exact%3AbioD%20OR%20gene_exact%3AbioB%29&format=json""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-122_cb391f9c9620	MetaCyc:7KAPSYN-CPLX	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P12998		"[{""reference_id"": ""UniProtKB:P12998"", ""source_assertion"": ""BioF is annotated to bind pyridoxal phosphate; current COFACTOR evidence includes direct E. coli kinetic/structural studies."", ""source_locator"": ""results[primaryAccession='P12998'].comments[commentType='COFACTOR']""}]"	"[{""id"": ""UniProtKB:P12998"", ""source_sha256"": ""45662ff7628d87bc987c1edfaa2d7bc5833866c44c4f275df5561cfe0aae392f"", ""source_version"": ""UniProt 2026_03 (2026-09-02); complete JSON retrieved 2026-10-11 UTC. Digest covers the whole retained response; accession-specific comments are selected by source locators."", ""title"": ""8-amino-7-oxononanoate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A83333%29%20AND%20%28gene_exact%3AbioC%20OR%20gene_exact%3AbioH%20OR%20gene_exact%3AbioF%20OR%20gene_exact%3AbioA%20OR%20gene_exact%3AbioD%20OR%20gene_exact%3AbioB%29&format=json""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-123_64e29640ed85	MetaCyc:DAPASYN-CPLX	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P12995		"[{""reference_id"": ""UniProtKB:P12995"", ""source_assertion"": ""BioA is annotated to bind pyridoxal phosphate; primary E. coli purification and kinetic studies establish the cofactor."", ""source_locator"": ""results[primaryAccession='P12995'].comments[commentType='COFACTOR']""}]"	"[{""id"": ""UniProtKB:P12995"", ""source_sha256"": ""45662ff7628d87bc987c1edfaa2d7bc5833866c44c4f275df5561cfe0aae392f"", ""source_version"": ""UniProt 2026_03 (2026-09-02); complete JSON retrieved 2026-10-11 UTC. Digest covers the whole retained response; accession-specific comments are selected by source locators."", ""title"": ""Adenosylmethionine-8-amino-7-oxononanoate aminotransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A83333%29%20AND%20%28gene_exact%3AbioC%20OR%20gene_exact%3AbioH%20OR%20gene_exact%3AbioF%20OR%20gene_exact%3AbioA%20OR%20gene_exact%3AbioD%20OR%20gene_exact%3AbioB%29&format=json""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-124_1aa15e0fd799	MetaCyc:DETHIOBIOTIN-SYN-CPLX	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P13000		"[{""reference_id"": ""UniProtKB:P13000"", ""source_assertion"": ""BioD1 binds one Mg(2+) per subunit; one structure shows a second Mg(2+). Direct-study annotation must not be simplified to a fixed universal two-metal stoichiometry."", ""source_locator"": ""comments[commentType='COFACTOR']""}]"	"[{""id"": ""UniProtKB:P13000"", ""source_sha256"": ""68998b083d250ab32f19afadb25be61bab48b48750590a03c5c84dabd5174a3a"", ""source_version"": ""UniProt 2026_03 (2026-09-02); complete JSON retrieved 2026-10-11 UTC. Digest covers the whole retained response; accession-specific comments are selected by source locators."", ""title"": ""ATP-dependent dethiobiotin synthetase BioD 1"", ""url"": ""https://rest.uniprot.org/uniprotkb/P13000.json""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-125_004ca658ce8c	MetaCyc:BIOTIN-SYN-CPLX	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:14704425|UniProtKB:P12996		"[{""reference_id"": ""UniProtKB:P12996"", ""source_assertion"": ""BioB binds one radical-SAM [4Fe-4S] cluster per subunit; the distinct [2Fe-2S] cluster is separately represented."", ""source_locator"": ""results[primaryAccession='P12996'].comments[commentType='COFACTOR']""}, {""reference_id"": ""PMID:14704425"", ""source_assertion"": ""The E. coli structure contains both Fe-S clusters and positions SAM and dethiobiotin between them. The structure favors a cluster-based sulfur mechanism and does not support a PLP-binding site."", ""source_locator"": ""P7-P8; Figure 1""}]"	"[{""id"": ""PMID:14704425"", ""source_sha256"": ""9bba38df80267bf7548a272497cb339127219a05053955a0b970b56b0cce4dec"", ""source_version"": ""Primary full article HTML retrieved 2026-10-11 UTC; inspected cited sections; digest covers entire retained HTML."", ""title"": ""Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1456065/""}, {""id"": ""UniProtKB:P12996"", ""source_sha256"": ""45662ff7628d87bc987c1edfaa2d7bc5833866c44c4f275df5561cfe0aae392f"", ""source_version"": ""UniProt 2026_03 (2026-09-02); complete JSON retrieved 2026-10-11 UTC. Digest covers the whole retained response; accession-specific comments are selected by source locators."", ""title"": ""Biotin synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A83333%29%20AND%20%28gene_exact%3AbioC%20OR%20gene_exact%3AbioH%20OR%20gene_exact%3AbioF%20OR%20gene_exact%3AbioA%20OR%20gene_exact%3AbioD%20OR%20gene_exact%3AbioB%29&format=json""}]"	""
pathwaymech:MetaCyc_BIOTIN-BIOSYNTHESIS-PWY_biotin-edge-126_9ec577c986e7	MetaCyc:BIOTIN-SYN-CPLX	pathwaymech:has_cofactor	CHEBI:190135	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:14704425|UniProtKB:P12996		"[{""reference_id"": ""UniProtKB:P12996"", ""source_assertion"": ""BioB binds one [2Fe-2S] cluster per subunit; this sulfur-associated cluster is distinct from the radical-SAM [4Fe-4S] cluster."", ""source_locator"": ""results[primaryAccession='P12996'].comments[commentType='COFACTOR']""}, {""reference_id"": ""PMID:14704425"", ""source_assertion"": ""The E. coli structure contains both Fe-S clusters and positions SAM and dethiobiotin between them. The structure favors a cluster-based sulfur mechanism and does not support a PLP-binding site."", ""source_locator"": ""P7-P8; Figure 1""}]"	"[{""id"": ""PMID:14704425"", ""source_sha256"": ""9bba38df80267bf7548a272497cb339127219a05053955a0b970b56b0cce4dec"", ""source_version"": ""Primary full article HTML retrieved 2026-10-11 UTC; inspected cited sections; digest covers entire retained HTML."", ""title"": ""Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1456065/""}, {""id"": ""UniProtKB:P12996"", ""source_sha256"": ""45662ff7628d87bc987c1edfaa2d7bc5833866c44c4f275df5561cfe0aae392f"", ""source_version"": ""UniProt 2026_03 (2026-09-02); complete JSON retrieved 2026-10-11 UTC. Digest covers the whole retained response; accession-specific comments are selected by source locators."", ""title"": ""Biotin synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A83333%29%20AND%20%28gene_exact%3AbioC%20OR%20gene_exact%3AbioH%20OR%20gene_exact%3AbioF%20OR%20gene_exact%3AbioA%20OR%20gene_exact%3AbioD%20OR%20gene_exact%3AbioB%29&format=json""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-001_fffaefeef268	RHEA:14658	BFO:0000050	MetaCyc:CALVIN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CALVIN-PWY|MetaCyc:RIB5PISOM-RXN|RHEA:14658	Native chemical classes are refined to the displayed Rhea structures; class-wide exact identity is not asserted.	"[{""reference_id"": ""MetaCyc:CALVIN-PWY"", ""source_assertion"": ""The complete pathway lists RIB5PISOM-RXN; its layout assigns L2R."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list | /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:RIB5PISOM-RXN"", ""source_assertion"": ""The native object supplies its exact side participants, coefficients, reaction direction and Rhea cross-reference."", ""source_locator"": ""/ptools-xml/Reaction/left | /ptools-xml/Reaction/right | /ptools-xml/Reaction/reaction-direction | /ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:14658"", ""source_assertion"": ""Rhea master 14657 links this approved direction and the native referenced direction; the chosen substrates/products orient cycle flow."", ""source_locator"": ""http://rdf.rhea-db.org/14657 rh:directionalReaction, rh:bidirectionalReaction; http://rdf.rhea-db.org/14658 rh:substrates, rh:products""}]"	"[{""id"": ""MetaCyc:CALVIN-PWY"", ""source_sha256"": ""1f83e394ed55042ad26a37073386f8a9da7212181b6a65b7f3f2483adeb1fc4b"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""Calvin-Benson-Bassham cycle"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CALVIN-PWY""}, {""id"": ""MetaCyc:RIB5PISOM-RXN"", ""source_sha256"": ""2ada9013fe0d335faeb50a43e4b7247cdd0265ddb2dcec287366927a5cb07b21"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""RIB5PISOM-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RIB5PISOM-RXN""}, {""id"": ""RHEA:14658"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/14658""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-002_7ce1f14d8345	CHEBI:58273	pathwaymech:consumes	RHEA:14658	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14658	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:14658"", ""source_assertion"": ""The substrates side contains 1 CHEBI:58273; formula C5H9O8P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/14658 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:14658"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/14658""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-003_87413908a5e6	RHEA:14658	pathwaymech:produces	CHEBI:58121	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14658	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:14658"", ""source_assertion"": ""The products side contains 1 CHEBI:58121; formula C5H9O8P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/14658 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:14658"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/14658""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-004_0f0c1f53a611	RHEA:19366	BFO:0000050	MetaCyc:CALVIN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CALVIN-PWY|MetaCyc:PHOSPHORIBULOKINASE-RXN|RHEA:19366	Native reaction and displayed chemical structures map to the selected charged directional equation.	"[{""reference_id"": ""MetaCyc:CALVIN-PWY"", ""source_assertion"": ""The complete pathway lists PHOSPHORIBULOKINASE-RXN; its layout assigns L2R."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list | /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:PHOSPHORIBULOKINASE-RXN"", ""source_assertion"": ""The native object supplies its exact side participants, coefficients, reaction direction and Rhea cross-reference."", ""source_locator"": ""/ptools-xml/Reaction/left | /ptools-xml/Reaction/right | /ptools-xml/Reaction/reaction-direction | /ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:19366"", ""source_assertion"": ""Rhea master 19365 links this approved direction and the native referenced direction; the chosen substrates/products orient cycle flow."", ""source_locator"": ""http://rdf.rhea-db.org/19365 rh:directionalReaction, rh:bidirectionalReaction; http://rdf.rhea-db.org/19366 rh:substrates, rh:products""}]"	"[{""id"": ""MetaCyc:CALVIN-PWY"", ""source_sha256"": ""1f83e394ed55042ad26a37073386f8a9da7212181b6a65b7f3f2483adeb1fc4b"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""Calvin-Benson-Bassham cycle"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CALVIN-PWY""}, {""id"": ""MetaCyc:PHOSPHORIBULOKINASE-RXN"", ""source_sha256"": ""196f5d7903273578f45d29a75f94e421eeebeeb45bdc868b35b7963a659d7bcf"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""PHOSPHORIBULOKINASE-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PHOSPHORIBULOKINASE-RXN""}, {""id"": ""RHEA:19366"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/19366""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-005_b482fb362f07	CHEBI:58121	pathwaymech:consumes	RHEA:19366	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19366	Coefficient 1 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:19366"", ""source_assertion"": ""The substrates side contains 1 CHEBI:58121; formula C5H9O8P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/19366 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:19366"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/19366""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-006_ee7439cb5f1f	CHEBI:30616	pathwaymech:consumes	RHEA:19366	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19366	Coefficient 1 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:19366"", ""source_assertion"": ""The substrates side contains 1 CHEBI:30616; formula C10H12N5O13P3, charge -4."", ""source_locator"": ""http://rdf.rhea-db.org/19366 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:19366"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/19366""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-007_99287e04d3eb	RHEA:19366	pathwaymech:produces	CHEBI:57870	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19366	Coefficient 1 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:19366"", ""source_assertion"": ""The products side contains 1 CHEBI:57870; formula C5H8O11P2, charge -4."", ""source_locator"": ""http://rdf.rhea-db.org/19366 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:19366"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/19366""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-008_a3fff9d09a79	RHEA:19366	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19366	Coefficient 1 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:19366"", ""source_assertion"": ""The products side contains 1 CHEBI:456216; formula C10H12N5O10P2, charge -3."", ""source_locator"": ""http://rdf.rhea-db.org/19366 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:19366"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/19366""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-009_0b8e611de46e	RHEA:19366	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19366	Coefficient 1 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:19366"", ""source_assertion"": ""The products side contains 1 CHEBI:15378; formula H, charge 1."", ""source_locator"": ""http://rdf.rhea-db.org/19366 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:19366"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/19366""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-010_cedbf4789fcc	RHEA:13679	BFO:0000050	MetaCyc:CALVIN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CALVIN-PWY|MetaCyc:RIBULP3EPIM-RXN|RHEA:13679	Native reaction and displayed chemical structures map to the selected charged directional equation.	"[{""reference_id"": ""MetaCyc:CALVIN-PWY"", ""source_assertion"": ""The complete pathway lists RIBULP3EPIM-RXN; its layout assigns R2L."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list | /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:RIBULP3EPIM-RXN"", ""source_assertion"": ""The native object supplies its exact side participants, coefficients, reaction direction and Rhea cross-reference."", ""source_locator"": ""/ptools-xml/Reaction/left | /ptools-xml/Reaction/right | /ptools-xml/Reaction/reaction-direction | /ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:13679"", ""source_assertion"": ""Rhea master 13677 links this approved direction and the native referenced direction; the chosen substrates/products orient cycle flow."", ""source_locator"": ""http://rdf.rhea-db.org/13677 rh:directionalReaction, rh:bidirectionalReaction; http://rdf.rhea-db.org/13679 rh:substrates, rh:products""}]"	"[{""id"": ""MetaCyc:CALVIN-PWY"", ""source_sha256"": ""1f83e394ed55042ad26a37073386f8a9da7212181b6a65b7f3f2483adeb1fc4b"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""Calvin-Benson-Bassham cycle"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CALVIN-PWY""}, {""id"": ""MetaCyc:RIBULP3EPIM-RXN"", ""source_sha256"": ""4cdc64ddd32cff05c412a5722adf2023e7ef97ccd8984fe32d22eecc1fd36aad"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""RIBULP3EPIM-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RIBULP3EPIM-RXN""}, {""id"": ""RHEA:13679"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-xylulose 5-phosphate => D-ribulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/13679""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-011_57d2f5fb94b8	CHEBI:57737	pathwaymech:consumes	RHEA:13679	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13679	Coefficient 1 in the selected charged equation; cycle multiplicity 2 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:13679"", ""source_assertion"": ""The substrates side contains 1 CHEBI:57737; formula C5H9O8P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/13679 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:13679"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-xylulose 5-phosphate => D-ribulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/13679""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-012_4af667256167	RHEA:13679	pathwaymech:produces	CHEBI:58121	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13679	Coefficient 1 in the selected charged equation; cycle multiplicity 2 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:13679"", ""source_assertion"": ""The products side contains 1 CHEBI:58121; formula C5H9O8P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/13679 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:13679"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-xylulose 5-phosphate => D-ribulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/13679""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-013_7b2871fd2a5e	RHEA:17462	BFO:0000050	MetaCyc:CALVIN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CALVIN-PWY|MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN|RHEA:17462	Native chemical classes are refined to the displayed Rhea structures; class-wide exact identity is not asserted.	"[{""reference_id"": ""MetaCyc:CALVIN-PWY"", ""source_assertion"": ""The complete pathway lists SEDOHEPTULOSE-BISPHOSPHATASE-RXN; its layout assigns L2R."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list | /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN"", ""source_assertion"": ""The native object supplies its exact side participants, coefficients, reaction direction and Rhea cross-reference."", ""source_locator"": ""/ptools-xml/Reaction/left | /ptools-xml/Reaction/right | /ptools-xml/Reaction/reaction-direction | /ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:17462"", ""source_assertion"": ""Rhea master 17461 links this approved direction and the native referenced direction; the chosen substrates/products orient cycle flow."", ""source_locator"": ""http://rdf.rhea-db.org/17461 rh:directionalReaction, rh:bidirectionalReaction; http://rdf.rhea-db.org/17462 rh:substrates, rh:products""}]"	"[{""id"": ""MetaCyc:CALVIN-PWY"", ""source_sha256"": ""1f83e394ed55042ad26a37073386f8a9da7212181b6a65b7f3f2483adeb1fc4b"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""Calvin-Benson-Bassham cycle"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CALVIN-PWY""}, {""id"": ""MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN"", ""source_sha256"": ""186b3f7eae721a7019cbb202f797a2afefbc44ddf71b8f7d874b190d10152a64"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""SEDOHEPTULOSE-BISPHOSPHATASE-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:SEDOHEPTULOSE-BISPHOSPHATASE-RXN""}, {""id"": ""RHEA:17462"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/17462""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-014_9bd45abe7b79	CHEBI:58335	pathwaymech:consumes	RHEA:17462	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17462	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:17462"", ""source_assertion"": ""The substrates side contains 1 CHEBI:58335; formula C7H12O13P2, charge -4."", ""source_locator"": ""http://rdf.rhea-db.org/17462 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:17462"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/17462""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-015_00611da38f21	CHEBI:15377	pathwaymech:consumes	RHEA:17462	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17462	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:17462"", ""source_assertion"": ""The substrates side contains 1 CHEBI:15377; formula H2O, charge 0."", ""source_locator"": ""http://rdf.rhea-db.org/17462 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:17462"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/17462""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-016_5baf2169be99	RHEA:17462	pathwaymech:produces	CHEBI:57483	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17462	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:17462"", ""source_assertion"": ""The products side contains 1 CHEBI:57483; formula C7H13O10P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/17462 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:17462"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/17462""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-017_5d2958c98bde	RHEA:17462	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17462	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:17462"", ""source_assertion"": ""The products side contains 1 CHEBI:43474; formula HO4P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/17462 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:17462"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/17462""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-018_34bbbef3e417	RHEA:27628	BFO:0000050	MetaCyc:CALVIN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:2TRANSKETO-RXN|MetaCyc:CALVIN-PWY|RHEA:27628	Native reaction and displayed chemical structures map to the selected charged directional equation.	"[{""reference_id"": ""MetaCyc:CALVIN-PWY"", ""source_assertion"": ""The complete pathway lists 2TRANSKETO-RXN; its layout assigns R2L."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list | /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:2TRANSKETO-RXN"", ""source_assertion"": ""The native object supplies its exact side participants, coefficients, reaction direction and Rhea cross-reference."", ""source_locator"": ""/ptools-xml/Reaction/left | /ptools-xml/Reaction/right | /ptools-xml/Reaction/reaction-direction | /ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:27628"", ""source_assertion"": ""Rhea master 27626 links this approved direction and the native referenced direction; the chosen substrates/products orient cycle flow."", ""source_locator"": ""http://rdf.rhea-db.org/27626 rh:directionalReaction, rh:bidirectionalReaction; http://rdf.rhea-db.org/27628 rh:substrates, rh:products""}]"	"[{""id"": ""MetaCyc:2TRANSKETO-RXN"", ""source_sha256"": ""1c89917f0e676f06ea7069d98e6d0dc6601a732726b7a81ab6cec64b9dbb1d6a"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""2TRANSKETO-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:2TRANSKETO-RXN""}, {""id"": ""MetaCyc:CALVIN-PWY"", ""source_sha256"": ""1f83e394ed55042ad26a37073386f8a9da7212181b6a65b7f3f2483adeb1fc4b"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""Calvin-Benson-Bassham cycle"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CALVIN-PWY""}, {""id"": ""RHEA:27628"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/27628""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-019_4db9838ebab7	CHEBI:57634	pathwaymech:consumes	RHEA:27628	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27628	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:27628"", ""source_assertion"": ""The substrates side contains 1 CHEBI:57634; formula C6H11O9P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/27628 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:27628"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/27628""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-020_8d7d43f69c0c	CHEBI:59776	pathwaymech:consumes	RHEA:27628	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27628	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:27628"", ""source_assertion"": ""The substrates side contains 1 CHEBI:59776; formula C3H5O6P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/27628 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:27628"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/27628""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-021_4939788ad6f3	RHEA:27628	pathwaymech:produces	CHEBI:16897	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27628	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:27628"", ""source_assertion"": ""The products side contains 1 CHEBI:16897; formula C4H7O7P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/27628 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:27628"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/27628""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-022_5e97c7c852e5	RHEA:27628	pathwaymech:produces	CHEBI:57737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27628	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:27628"", ""source_assertion"": ""The products side contains 1 CHEBI:57737; formula C5H9O8P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/27628 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:27628"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/27628""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-023_1db801f8f102	RHEA:10509	BFO:0000050	MetaCyc:CALVIN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:1TRANSKETO-RXN|MetaCyc:CALVIN-PWY|RHEA:10509	Native chemical classes are refined to the displayed Rhea structures; class-wide exact identity is not asserted.	"[{""reference_id"": ""MetaCyc:CALVIN-PWY"", ""source_assertion"": ""The complete pathway lists 1TRANSKETO-RXN; its layout assigns L2R."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list | /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:1TRANSKETO-RXN"", ""source_assertion"": ""The native object supplies its exact side participants, coefficients, reaction direction and Rhea cross-reference."", ""source_locator"": ""/ptools-xml/Reaction/left | /ptools-xml/Reaction/right | /ptools-xml/Reaction/reaction-direction | /ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:10509"", ""source_assertion"": ""Rhea master 10508 links this approved direction and the native referenced direction; the chosen substrates/products orient cycle flow."", ""source_locator"": ""http://rdf.rhea-db.org/10508 rh:directionalReaction, rh:bidirectionalReaction; http://rdf.rhea-db.org/10509 rh:substrates, rh:products""}]"	"[{""id"": ""MetaCyc:1TRANSKETO-RXN"", ""source_sha256"": ""bb66b8e5c71f711d96c94b95d660ed49b0385e35c9d3fe59461c385221b302b0"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""1TRANSKETO-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:1TRANSKETO-RXN""}, {""id"": ""MetaCyc:CALVIN-PWY"", ""source_sha256"": ""1f83e394ed55042ad26a37073386f8a9da7212181b6a65b7f3f2483adeb1fc4b"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""Calvin-Benson-Bassham cycle"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CALVIN-PWY""}, {""id"": ""RHEA:10509"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/10509""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-024_2d2e66538083	CHEBI:57483	pathwaymech:consumes	RHEA:10509	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10509	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:10509"", ""source_assertion"": ""The substrates side contains 1 CHEBI:57483; formula C7H13O10P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/10509 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:10509"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/10509""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-025_d3a59e330bed	CHEBI:59776	pathwaymech:consumes	RHEA:10509	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10509	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:10509"", ""source_assertion"": ""The substrates side contains 1 CHEBI:59776; formula C3H5O6P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/10509 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:10509"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/10509""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-026_3374b4d9da48	RHEA:10509	pathwaymech:produces	CHEBI:58273	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10509	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:10509"", ""source_assertion"": ""The products side contains 1 CHEBI:58273; formula C5H9O8P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/10509 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:10509"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/10509""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-027_5955d7c6bad5	RHEA:10509	pathwaymech:produces	CHEBI:57737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10509	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:10509"", ""source_assertion"": ""The products side contains 1 CHEBI:57737; formula C5H9O8P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/10509 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:10509"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/10509""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-028_98fe91f9c5de	RHEA:11065	BFO:0000050	MetaCyc:CALVIN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CALVIN-PWY|MetaCyc:F16BDEPHOS-RXN|RHEA:11065	Native reaction and displayed chemical structures map to the selected charged directional equation.	"[{""reference_id"": ""MetaCyc:CALVIN-PWY"", ""source_assertion"": ""The complete pathway lists F16BDEPHOS-RXN; its layout assigns L2R."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list | /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:F16BDEPHOS-RXN"", ""source_assertion"": ""The native object supplies its exact side participants, coefficients, reaction direction and Rhea cross-reference."", ""source_locator"": ""/ptools-xml/Reaction/left | /ptools-xml/Reaction/right | /ptools-xml/Reaction/reaction-direction | /ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:11065"", ""source_assertion"": ""Rhea master 11064 links this approved direction and the native referenced direction; the chosen substrates/products orient cycle flow."", ""source_locator"": ""http://rdf.rhea-db.org/11064 rh:directionalReaction, rh:bidirectionalReaction; http://rdf.rhea-db.org/11065 rh:substrates, rh:products""}]"	"[{""id"": ""MetaCyc:CALVIN-PWY"", ""source_sha256"": ""1f83e394ed55042ad26a37073386f8a9da7212181b6a65b7f3f2483adeb1fc4b"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""Calvin-Benson-Bassham cycle"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CALVIN-PWY""}, {""id"": ""MetaCyc:F16BDEPHOS-RXN"", ""source_sha256"": ""f946c8468937c1e4ebeaafe62eee55ab7aab44d46738ad6863dd48fb15876d84"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""F16BDEPHOS-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:F16BDEPHOS-RXN""}, {""id"": ""RHEA:11065"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/11065""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-029_bb2d3febc9e2	CHEBI:32966	pathwaymech:consumes	RHEA:11065	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11065	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:11065"", ""source_assertion"": ""The substrates side contains 1 CHEBI:32966; formula C6H10O12P2, charge -4."", ""source_locator"": ""http://rdf.rhea-db.org/11065 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:11065"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/11065""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-030_38c991676431	CHEBI:15377	pathwaymech:consumes	RHEA:11065	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11065	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:11065"", ""source_assertion"": ""The substrates side contains 1 CHEBI:15377; formula H2O, charge 0."", ""source_locator"": ""http://rdf.rhea-db.org/11065 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:11065"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/11065""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-031_30ea0b73c379	RHEA:11065	pathwaymech:produces	CHEBI:57634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11065	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:11065"", ""source_assertion"": ""The products side contains 1 CHEBI:57634; formula C6H11O9P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/11065 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:11065"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/11065""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-032_ded1b3026874	RHEA:11065	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11065	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:11065"", ""source_assertion"": ""The products side contains 1 CHEBI:43474; formula HO4P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/11065 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:11065"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/11065""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-033_4e6d07576fa5	RHEA:30168	BFO:0000050	MetaCyc:CALVIN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CALVIN-PWY|MetaCyc:SEDOBISALDOL-RXN|RHEA:30168	Native reaction and displayed chemical structures map to the selected charged directional equation.	"[{""reference_id"": ""MetaCyc:CALVIN-PWY"", ""source_assertion"": ""The complete pathway lists SEDOBISALDOL-RXN; its layout assigns R2L."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list | /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:SEDOBISALDOL-RXN"", ""source_assertion"": ""The native object supplies its exact side participants, coefficients, reaction direction and Rhea cross-reference."", ""source_locator"": ""/ptools-xml/Reaction/left | /ptools-xml/Reaction/right | /ptools-xml/Reaction/reaction-direction | /ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:30168"", ""source_assertion"": ""Rhea master 30167 links this approved direction and the native referenced direction; the chosen substrates/products orient cycle flow."", ""source_locator"": ""http://rdf.rhea-db.org/30167 rh:directionalReaction, rh:bidirectionalReaction; http://rdf.rhea-db.org/30168 rh:substrates, rh:products""}]"	"[{""id"": ""MetaCyc:CALVIN-PWY"", ""source_sha256"": ""1f83e394ed55042ad26a37073386f8a9da7212181b6a65b7f3f2483adeb1fc4b"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""Calvin-Benson-Bassham cycle"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CALVIN-PWY""}, {""id"": ""MetaCyc:SEDOBISALDOL-RXN"", ""source_sha256"": ""263e4acda048cd296ded1d2421d26625c2c45806db10713133726bcad4b5e3b3"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""SEDOBISALDOL-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:SEDOBISALDOL-RXN""}, {""id"": ""RHEA:30168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphate"", ""url"": ""https://www.rhea-db.org/rhea/30168""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-034_4eed3f7298c5	CHEBI:16897	pathwaymech:consumes	RHEA:30168	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30168	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:30168"", ""source_assertion"": ""The substrates side contains 1 CHEBI:16897; formula C4H7O7P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/30168 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:30168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphate"", ""url"": ""https://www.rhea-db.org/rhea/30168""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-035_dd84be908d79	CHEBI:57642	pathwaymech:consumes	RHEA:30168	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30168	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:30168"", ""source_assertion"": ""The substrates side contains 1 CHEBI:57642; formula C3H5O6P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/30168 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:30168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphate"", ""url"": ""https://www.rhea-db.org/rhea/30168""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-036_2de9b14d3f39	RHEA:30168	pathwaymech:produces	CHEBI:58335	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30168	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:30168"", ""source_assertion"": ""The products side contains 1 CHEBI:58335; formula C7H12O13P2, charge -4."", ""source_locator"": ""http://rdf.rhea-db.org/30168 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:30168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphate"", ""url"": ""https://www.rhea-db.org/rhea/30168""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-037_0f6746c53778	RHEA:14731	BFO:0000050	MetaCyc:CALVIN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CALVIN-PWY|MetaCyc:F16ALDOLASE-RXN|RHEA:14731	Native reaction and displayed chemical structures map to the selected charged directional equation.	"[{""reference_id"": ""MetaCyc:CALVIN-PWY"", ""source_assertion"": ""The complete pathway lists F16ALDOLASE-RXN; its layout assigns R2L."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list | /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:F16ALDOLASE-RXN"", ""source_assertion"": ""The native object supplies its exact side participants, coefficients, reaction direction and Rhea cross-reference."", ""source_locator"": ""/ptools-xml/Reaction/left | /ptools-xml/Reaction/right | /ptools-xml/Reaction/reaction-direction | /ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:14731"", ""source_assertion"": ""Rhea master 14729 links this approved direction and the native referenced direction; the chosen substrates/products orient cycle flow."", ""source_locator"": ""http://rdf.rhea-db.org/14729 rh:directionalReaction, rh:bidirectionalReaction; http://rdf.rhea-db.org/14731 rh:substrates, rh:products""}]"	"[{""id"": ""MetaCyc:CALVIN-PWY"", ""source_sha256"": ""1f83e394ed55042ad26a37073386f8a9da7212181b6a65b7f3f2483adeb1fc4b"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""Calvin-Benson-Bassham cycle"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CALVIN-PWY""}, {""id"": ""MetaCyc:F16ALDOLASE-RXN"", ""source_sha256"": ""6f673ca9593ee003d7c9abb9058cce7cd256807600ab8f2b1a77adcdee906ab2"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""F16ALDOLASE-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:F16ALDOLASE-RXN""}, {""id"": ""RHEA:14731"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate"", ""url"": ""https://www.rhea-db.org/rhea/14731""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-038_6ac0931ce1ce	CHEBI:59776	pathwaymech:consumes	RHEA:14731	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14731	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:14731"", ""source_assertion"": ""The substrates side contains 1 CHEBI:59776; formula C3H5O6P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/14731 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:14731"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate"", ""url"": ""https://www.rhea-db.org/rhea/14731""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-039_21330e158cb4	CHEBI:57642	pathwaymech:consumes	RHEA:14731	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14731	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:14731"", ""source_assertion"": ""The substrates side contains 1 CHEBI:57642; formula C3H5O6P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/14731 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:14731"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate"", ""url"": ""https://www.rhea-db.org/rhea/14731""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-040_9a0a71be0fc0	RHEA:14731	pathwaymech:produces	CHEBI:32966	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14731	Coefficient 1 in the selected charged equation; cycle multiplicity 1 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:14731"", ""source_assertion"": ""The products side contains 1 CHEBI:32966; formula C6H10O12P2, charge -4."", ""source_locator"": ""http://rdf.rhea-db.org/14731 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:14731"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate"", ""url"": ""https://www.rhea-db.org/rhea/14731""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-041_6a2e54089fb2	RHEA:18586	BFO:0000050	MetaCyc:CALVIN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CALVIN-PWY|MetaCyc:TRIOSEPISOMERIZATION-RXN|RHEA:18586	Native reaction and displayed chemical structures map to the selected charged directional equation.	"[{""reference_id"": ""MetaCyc:CALVIN-PWY"", ""source_assertion"": ""The complete pathway lists TRIOSEPISOMERIZATION-RXN; its layout assigns L2R."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list | /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:TRIOSEPISOMERIZATION-RXN"", ""source_assertion"": ""The native object supplies its exact side participants, coefficients, reaction direction and Rhea cross-reference."", ""source_locator"": ""/ptools-xml/Reaction/left | /ptools-xml/Reaction/right | /ptools-xml/Reaction/reaction-direction | /ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:18586"", ""source_assertion"": ""Rhea master 18585 links this approved direction and the native referenced direction; the chosen substrates/products orient cycle flow."", ""source_locator"": ""http://rdf.rhea-db.org/18585 rh:directionalReaction, rh:bidirectionalReaction; http://rdf.rhea-db.org/18586 rh:substrates, rh:products""}]"	"[{""id"": ""MetaCyc:CALVIN-PWY"", ""source_sha256"": ""1f83e394ed55042ad26a37073386f8a9da7212181b6a65b7f3f2483adeb1fc4b"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""Calvin-Benson-Bassham cycle"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CALVIN-PWY""}, {""id"": ""MetaCyc:TRIOSEPISOMERIZATION-RXN"", ""source_sha256"": ""03ee123167ea2c00497e79f748df3f2c8f3748fe40036872a5187a8a1ebd3386"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""TRIOSEPISOMERIZATION-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:TRIOSEPISOMERIZATION-RXN""}, {""id"": ""RHEA:18586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphate"", ""url"": ""https://www.rhea-db.org/rhea/18586""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-042_373e64b32538	CHEBI:59776	pathwaymech:consumes	RHEA:18586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18586	Coefficient 1 in the selected charged equation; cycle multiplicity 2 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:18586"", ""source_assertion"": ""The substrates side contains 1 CHEBI:59776; formula C3H5O6P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/18586 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:18586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphate"", ""url"": ""https://www.rhea-db.org/rhea/18586""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-043_6a2db743ccb8	RHEA:18586	pathwaymech:produces	CHEBI:57642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18586	Coefficient 1 in the selected charged equation; cycle multiplicity 2 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:18586"", ""source_assertion"": ""The products side contains 1 CHEBI:57642; formula C3H5O6P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/18586 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:18586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphate"", ""url"": ""https://www.rhea-db.org/rhea/18586""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-044_182eefdabe61	RHEA:10298	BFO:0000050	MetaCyc:CALVIN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:1.2.1.13-RXN|MetaCyc:CALVIN-PWY|RHEA:10298	Native reaction and displayed chemical structures map to the selected charged directional equation.	"[{""reference_id"": ""MetaCyc:CALVIN-PWY"", ""source_assertion"": ""The complete pathway lists 1.2.1.13-RXN; its layout assigns R2L."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list | /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:1.2.1.13-RXN"", ""source_assertion"": ""The native object supplies its exact side participants, coefficients, reaction direction and Rhea cross-reference."", ""source_locator"": ""/ptools-xml/Reaction/left | /ptools-xml/Reaction/right | /ptools-xml/Reaction/reaction-direction | /ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:10298"", ""source_assertion"": ""Rhea master 10296 links this approved direction and the native referenced direction; the chosen substrates/products orient cycle flow."", ""source_locator"": ""http://rdf.rhea-db.org/10296 rh:directionalReaction, rh:bidirectionalReaction; http://rdf.rhea-db.org/10298 rh:substrates, rh:products""}]"	"[{""id"": ""MetaCyc:1.2.1.13-RXN"", ""source_sha256"": ""f6b571ee3c8d29dcac8e436c90a0d391b72410447d727548f695a258f65646e9"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""1.2.1.13-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:1.2.1.13-RXN""}, {""id"": ""MetaCyc:CALVIN-PWY"", ""source_sha256"": ""1f83e394ed55042ad26a37073386f8a9da7212181b6a65b7f3f2483adeb1fc4b"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""Calvin-Benson-Bassham cycle"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CALVIN-PWY""}, {""id"": ""RHEA:10298"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/10298""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-045_6e92de8768e5	CHEBI:57604	pathwaymech:consumes	RHEA:10298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10298	Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:10298"", ""source_assertion"": ""The substrates side contains 1 CHEBI:57604; formula C3H4O10P2, charge -4."", ""source_locator"": ""http://rdf.rhea-db.org/10298 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:10298"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/10298""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-046_df94fc810b33	CHEBI:57783	pathwaymech:consumes	RHEA:10298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10298	Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:10298"", ""source_assertion"": ""The substrates side contains 1 CHEBI:57783; formula C21H26N7O17P3, charge -4."", ""source_locator"": ""http://rdf.rhea-db.org/10298 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:10298"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/10298""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-047_9925289594c8	CHEBI:15378	pathwaymech:consumes	RHEA:10298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10298	Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:10298"", ""source_assertion"": ""The substrates side contains 1 CHEBI:15378; formula H, charge 1."", ""source_locator"": ""http://rdf.rhea-db.org/10298 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:10298"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/10298""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-048_e52ad25fb623	RHEA:10298	pathwaymech:produces	CHEBI:59776	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10298	Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:10298"", ""source_assertion"": ""The products side contains 1 CHEBI:59776; formula C3H5O6P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/10298 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:10298"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/10298""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-049_d525b60c6ed5	RHEA:10298	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10298	Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:10298"", ""source_assertion"": ""The products side contains 1 CHEBI:43474; formula HO4P, charge -2."", ""source_locator"": ""http://rdf.rhea-db.org/10298 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:10298"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/10298""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-050_b2d9dac87d68	RHEA:10298	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10298	Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:10298"", ""source_assertion"": ""The products side contains 1 CHEBI:58349; formula C21H25N7O17P3, charge -3."", ""source_locator"": ""http://rdf.rhea-db.org/10298 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:10298"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/10298""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-051_99f83c4be286	RHEA:14802	BFO:0000050	MetaCyc:CALVIN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CALVIN-PWY|MetaCyc:PHOSGLYPHOS-RXN|RHEA:14802	Native reaction and displayed chemical structures map to the selected charged directional equation.	"[{""reference_id"": ""MetaCyc:CALVIN-PWY"", ""source_assertion"": ""The complete pathway lists PHOSGLYPHOS-RXN; its layout assigns L2R."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list | /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:PHOSGLYPHOS-RXN"", ""source_assertion"": ""The native object supplies its exact side participants, coefficients, reaction direction and Rhea cross-reference."", ""source_locator"": ""/ptools-xml/Reaction/left | /ptools-xml/Reaction/right | /ptools-xml/Reaction/reaction-direction | /ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:14802"", ""source_assertion"": ""Rhea master 14801 links this approved direction and the native referenced direction; the chosen substrates/products orient cycle flow."", ""source_locator"": ""http://rdf.rhea-db.org/14801 rh:directionalReaction, rh:bidirectionalReaction; http://rdf.rhea-db.org/14802 rh:substrates, rh:products""}]"	"[{""id"": ""MetaCyc:CALVIN-PWY"", ""source_sha256"": ""1f83e394ed55042ad26a37073386f8a9da7212181b6a65b7f3f2483adeb1fc4b"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""Calvin-Benson-Bassham cycle"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CALVIN-PWY""}, {""id"": ""MetaCyc:PHOSGLYPHOS-RXN"", ""source_sha256"": ""3d85e3b9f1d86622dfd0ef99deaea70784f0f961add06d74ceafd99b8fac3a3d"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""PHOSGLYPHOS-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PHOSGLYPHOS-RXN""}, {""id"": ""RHEA:14802"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADP"", ""url"": ""https://www.rhea-db.org/rhea/14802""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-052_122a1ade39cc	CHEBI:58272	pathwaymech:consumes	RHEA:14802	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14802	Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:14802"", ""source_assertion"": ""The substrates side contains 1 CHEBI:58272; formula C3H4O7P, charge -3."", ""source_locator"": ""http://rdf.rhea-db.org/14802 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:14802"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADP"", ""url"": ""https://www.rhea-db.org/rhea/14802""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-053_b3caeebc36fb	CHEBI:30616	pathwaymech:consumes	RHEA:14802	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14802	Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:14802"", ""source_assertion"": ""The substrates side contains 1 CHEBI:30616; formula C10H12N5O13P3, charge -4."", ""source_locator"": ""http://rdf.rhea-db.org/14802 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:14802"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADP"", ""url"": ""https://www.rhea-db.org/rhea/14802""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-054_d46ae5f3e963	RHEA:14802	pathwaymech:produces	CHEBI:57604	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14802	Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:14802"", ""source_assertion"": ""The products side contains 1 CHEBI:57604; formula C3H4O10P2, charge -4."", ""source_locator"": ""http://rdf.rhea-db.org/14802 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:14802"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADP"", ""url"": ""https://www.rhea-db.org/rhea/14802""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-055_74334831c791	RHEA:14802	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14802	Coefficient 1 in the selected charged equation; cycle multiplicity 6 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:14802"", ""source_assertion"": ""The products side contains 1 CHEBI:456216; formula C10H12N5O10P2, charge -3."", ""source_locator"": ""http://rdf.rhea-db.org/14802 rh:products; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:14802"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADP"", ""url"": ""https://www.rhea-db.org/rhea/14802""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-056_37adfdf0b031	RHEA:23126	BFO:0000050	MetaCyc:CALVIN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CALVIN-PWY|MetaCyc:RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN|RHEA:23126	Native reaction and displayed chemical structures map to the selected charged directional equation.	"[{""reference_id"": ""MetaCyc:CALVIN-PWY"", ""source_assertion"": ""The complete pathway lists RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN; its layout assigns R2L."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list | /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN"", ""source_assertion"": ""The native object supplies its exact side participants, coefficients, reaction direction and Rhea cross-reference."", ""source_locator"": ""/ptools-xml/Reaction/left | /ptools-xml/Reaction/right | /ptools-xml/Reaction/reaction-direction | /ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:23126"", ""source_assertion"": ""Rhea master 23124 links this approved direction and the native referenced direction; the chosen substrates/products orient cycle flow."", ""source_locator"": ""http://rdf.rhea-db.org/23124 rh:directionalReaction, rh:bidirectionalReaction; http://rdf.rhea-db.org/23126 rh:substrates, rh:products""}]"	"[{""id"": ""MetaCyc:CALVIN-PWY"", ""source_sha256"": ""1f83e394ed55042ad26a37073386f8a9da7212181b6a65b7f3f2483adeb1fc4b"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""Calvin-Benson-Bassham cycle"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CALVIN-PWY""}, {""id"": ""MetaCyc:RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN"", ""source_sha256"": ""97c5d2aacc05d19cd4c8bf18f159c8135e3f34c3e0b29acc18a6be4072bc8816"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN""}, {""id"": ""RHEA:23126"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23126""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-057_4e17ae2ddf4f	CHEBI:57870	pathwaymech:consumes	RHEA:23126	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23126	Coefficient 1 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:23126"", ""source_assertion"": ""The substrates side contains 1 CHEBI:57870; formula C5H8O11P2, charge -4."", ""source_locator"": ""http://rdf.rhea-db.org/23126 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:23126"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23126""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-058_5b14a44defb7	CHEBI:16526	pathwaymech:consumes	RHEA:23126	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23126	Coefficient 1 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:23126"", ""source_assertion"": ""The substrates side contains 1 CHEBI:16526; formula CO2, charge 0."", ""source_locator"": ""http://rdf.rhea-db.org/23126 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:23126"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23126""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-059_2792a39271ad	CHEBI:15377	pathwaymech:consumes	RHEA:23126	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23126	Coefficient 1 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:23126"", ""source_assertion"": ""The substrates side contains 1 CHEBI:15377; formula H2O, charge 0."", ""source_locator"": ""http://rdf.rhea-db.org/23126 rh:substrates; side rh:contains1 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:23126"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23126""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-060_1566d386871f	RHEA:23126	pathwaymech:produces	CHEBI:58272	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23126	Coefficient 2 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:23126"", ""source_assertion"": ""The products side contains 2 CHEBI:58272; formula C3H4O7P, charge -3."", ""source_locator"": ""http://rdf.rhea-db.org/23126 rh:products; side rh:contains2 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:23126"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23126""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-061_aa7ecd836d8e	RHEA:23126	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23126	Coefficient 2 in the selected charged equation; cycle multiplicity 3 is separate from this reaction coefficient.	"[{""reference_id"": ""RHEA:23126"", ""source_assertion"": ""The products side contains 2 CHEBI:15378; formula H, charge 1."", ""source_locator"": ""http://rdf.rhea-db.org/23126 rh:products; side rh:contains2 -> rh:compound -> rh:accession, rh:formula, rh:charge""}]"	"[{""id"": ""RHEA:23126"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23126""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-062_0ad7e155a4b2	RHEA:14658	RO:0002413	RHEA:19366	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14658|RHEA:19366	Chemical continuity through CHEBI:58121. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:14658"", ""source_assertion"": ""The product side includes CHEBI:58121."", ""source_locator"": ""http://rdf.rhea-db.org/14658 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:19366"", ""source_assertion"": ""The substrate side includes CHEBI:58121."", ""source_locator"": ""http://rdf.rhea-db.org/19366 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14658"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/14658""}, {""id"": ""RHEA:19366"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/19366""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-063_636523af60a0	RHEA:19366	RO:0002413	RHEA:23126	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19366|RHEA:23126	Chemical continuity through CHEBI:57870. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:19366"", ""source_assertion"": ""The product side includes CHEBI:57870."", ""source_locator"": ""http://rdf.rhea-db.org/19366 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:23126"", ""source_assertion"": ""The substrate side includes CHEBI:57870."", ""source_locator"": ""http://rdf.rhea-db.org/23126 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19366"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/19366""}, {""id"": ""RHEA:23126"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23126""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-064_bb86db91bff9	RHEA:13679	RO:0002413	RHEA:19366	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13679|RHEA:19366	Chemical continuity through CHEBI:58121. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:13679"", ""source_assertion"": ""The product side includes CHEBI:58121."", ""source_locator"": ""http://rdf.rhea-db.org/13679 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:19366"", ""source_assertion"": ""The substrate side includes CHEBI:58121."", ""source_locator"": ""http://rdf.rhea-db.org/19366 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13679"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-xylulose 5-phosphate => D-ribulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/13679""}, {""id"": ""RHEA:19366"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/19366""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-065_b94cecaefb5a	RHEA:17462	RO:0002413	RHEA:10509	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10509|RHEA:17462	Chemical continuity through CHEBI:57483. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:17462"", ""source_assertion"": ""The product side includes CHEBI:57483."", ""source_locator"": ""http://rdf.rhea-db.org/17462 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:10509"", ""source_assertion"": ""The substrate side includes CHEBI:57483."", ""source_locator"": ""http://rdf.rhea-db.org/10509 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10509"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/10509""}, {""id"": ""RHEA:17462"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/17462""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-066_9e21b30609a5	RHEA:27628	RO:0002413	RHEA:13679	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13679|RHEA:27628	Chemical continuity through CHEBI:57737. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:27628"", ""source_assertion"": ""The product side includes CHEBI:57737."", ""source_locator"": ""http://rdf.rhea-db.org/27628 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:13679"", ""source_assertion"": ""The substrate side includes CHEBI:57737."", ""source_locator"": ""http://rdf.rhea-db.org/13679 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13679"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-xylulose 5-phosphate => D-ribulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/13679""}, {""id"": ""RHEA:27628"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/27628""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-067_9ae5362843ea	RHEA:27628	RO:0002413	RHEA:30168	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27628|RHEA:30168	Chemical continuity through CHEBI:16897. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:27628"", ""source_assertion"": ""The product side includes CHEBI:16897."", ""source_locator"": ""http://rdf.rhea-db.org/27628 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:30168"", ""source_assertion"": ""The substrate side includes CHEBI:16897."", ""source_locator"": ""http://rdf.rhea-db.org/30168 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27628"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/27628""}, {""id"": ""RHEA:30168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphate"", ""url"": ""https://www.rhea-db.org/rhea/30168""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-068_c4f8f7d94b34	RHEA:10509	RO:0002413	RHEA:14658	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10509|RHEA:14658	Chemical continuity through CHEBI:58273. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:10509"", ""source_assertion"": ""The product side includes CHEBI:58273."", ""source_locator"": ""http://rdf.rhea-db.org/10509 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:14658"", ""source_assertion"": ""The substrate side includes CHEBI:58273."", ""source_locator"": ""http://rdf.rhea-db.org/14658 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10509"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/10509""}, {""id"": ""RHEA:14658"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/14658""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-069_e708ddafdcfe	RHEA:10509	RO:0002413	RHEA:13679	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10509|RHEA:13679	Chemical continuity through CHEBI:57737. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:10509"", ""source_assertion"": ""The product side includes CHEBI:57737."", ""source_locator"": ""http://rdf.rhea-db.org/10509 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:13679"", ""source_assertion"": ""The substrate side includes CHEBI:57737."", ""source_locator"": ""http://rdf.rhea-db.org/13679 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10509"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/10509""}, {""id"": ""RHEA:13679"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-xylulose 5-phosphate => D-ribulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/13679""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-070_e21737d9335d	RHEA:11065	RO:0002413	RHEA:27628	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11065|RHEA:27628	Chemical continuity through CHEBI:57634. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:11065"", ""source_assertion"": ""The product side includes CHEBI:57634."", ""source_locator"": ""http://rdf.rhea-db.org/11065 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:27628"", ""source_assertion"": ""The substrate side includes CHEBI:57634."", ""source_locator"": ""http://rdf.rhea-db.org/27628 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11065"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/11065""}, {""id"": ""RHEA:27628"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/27628""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-071_fa0c1013d342	RHEA:30168	RO:0002413	RHEA:17462	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17462|RHEA:30168	Chemical continuity through CHEBI:58335. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:30168"", ""source_assertion"": ""The product side includes CHEBI:58335."", ""source_locator"": ""http://rdf.rhea-db.org/30168 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:17462"", ""source_assertion"": ""The substrate side includes CHEBI:58335."", ""source_locator"": ""http://rdf.rhea-db.org/17462 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17462"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/17462""}, {""id"": ""RHEA:30168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphate"", ""url"": ""https://www.rhea-db.org/rhea/30168""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-072_f6c2a7cd5df9	RHEA:14731	RO:0002413	RHEA:11065	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11065|RHEA:14731	Chemical continuity through CHEBI:32966. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:14731"", ""source_assertion"": ""The product side includes CHEBI:32966."", ""source_locator"": ""http://rdf.rhea-db.org/14731 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:11065"", ""source_assertion"": ""The substrate side includes CHEBI:32966."", ""source_locator"": ""http://rdf.rhea-db.org/11065 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11065"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/11065""}, {""id"": ""RHEA:14731"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate"", ""url"": ""https://www.rhea-db.org/rhea/14731""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-073_486c443fcbe0	RHEA:18586	RO:0002413	RHEA:30168	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18586|RHEA:30168	Chemical continuity through CHEBI:57642. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:18586"", ""source_assertion"": ""The product side includes CHEBI:57642."", ""source_locator"": ""http://rdf.rhea-db.org/18586 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:30168"", ""source_assertion"": ""The substrate side includes CHEBI:57642."", ""source_locator"": ""http://rdf.rhea-db.org/30168 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphate"", ""url"": ""https://www.rhea-db.org/rhea/18586""}, {""id"": ""RHEA:30168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphate"", ""url"": ""https://www.rhea-db.org/rhea/30168""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-074_d3c15c57fa16	RHEA:18586	RO:0002413	RHEA:14731	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14731|RHEA:18586	Chemical continuity through CHEBI:57642. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:18586"", ""source_assertion"": ""The product side includes CHEBI:57642."", ""source_locator"": ""http://rdf.rhea-db.org/18586 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:14731"", ""source_assertion"": ""The substrate side includes CHEBI:57642."", ""source_locator"": ""http://rdf.rhea-db.org/14731 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14731"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate"", ""url"": ""https://www.rhea-db.org/rhea/14731""}, {""id"": ""RHEA:18586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphate"", ""url"": ""https://www.rhea-db.org/rhea/18586""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-075_2d088c9b1a85	RHEA:10298	RO:0002413	RHEA:27628	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10298|RHEA:27628	Chemical continuity through CHEBI:59776. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:10298"", ""source_assertion"": ""The product side includes CHEBI:59776."", ""source_locator"": ""http://rdf.rhea-db.org/10298 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:27628"", ""source_assertion"": ""The substrate side includes CHEBI:59776."", ""source_locator"": ""http://rdf.rhea-db.org/27628 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10298"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/10298""}, {""id"": ""RHEA:27628"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/27628""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-076_0bca4b0edea1	RHEA:10298	RO:0002413	RHEA:10509	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10298|RHEA:10509	Chemical continuity through CHEBI:59776. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:10298"", ""source_assertion"": ""The product side includes CHEBI:59776."", ""source_locator"": ""http://rdf.rhea-db.org/10298 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:10509"", ""source_assertion"": ""The substrate side includes CHEBI:59776."", ""source_locator"": ""http://rdf.rhea-db.org/10509 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10298"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/10298""}, {""id"": ""RHEA:10509"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/10509""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-077_592bb7b0accb	RHEA:10298	RO:0002413	RHEA:14731	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10298|RHEA:14731	Chemical continuity through CHEBI:59776. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:10298"", ""source_assertion"": ""The product side includes CHEBI:59776."", ""source_locator"": ""http://rdf.rhea-db.org/10298 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:14731"", ""source_assertion"": ""The substrate side includes CHEBI:59776."", ""source_locator"": ""http://rdf.rhea-db.org/14731 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10298"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/10298""}, {""id"": ""RHEA:14731"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate"", ""url"": ""https://www.rhea-db.org/rhea/14731""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-078_cbb0b422ae5d	RHEA:10298	RO:0002413	RHEA:18586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10298|RHEA:18586	Chemical continuity through CHEBI:59776. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:10298"", ""source_assertion"": ""The product side includes CHEBI:59776."", ""source_locator"": ""http://rdf.rhea-db.org/10298 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:18586"", ""source_assertion"": ""The substrate side includes CHEBI:59776."", ""source_locator"": ""http://rdf.rhea-db.org/18586 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10298"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/10298""}, {""id"": ""RHEA:18586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphate"", ""url"": ""https://www.rhea-db.org/rhea/18586""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-079_3a102ba75227	RHEA:14802	RO:0002413	RHEA:10298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10298|RHEA:14802	Chemical continuity through CHEBI:57604. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:14802"", ""source_assertion"": ""The product side includes CHEBI:57604."", ""source_locator"": ""http://rdf.rhea-db.org/14802 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:10298"", ""source_assertion"": ""The substrate side includes CHEBI:57604."", ""source_locator"": ""http://rdf.rhea-db.org/10298 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10298"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/10298""}, {""id"": ""RHEA:14802"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADP"", ""url"": ""https://www.rhea-db.org/rhea/14802""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-080_fa5716faf2b7	RHEA:23126	RO:0002413	RHEA:14802	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14802|RHEA:23126	Chemical continuity through CHEBI:58272. This does not assert equal flux through every cycle edge.	"[{""reference_id"": ""RHEA:23126"", ""source_assertion"": ""The product side includes CHEBI:58272."", ""source_locator"": ""http://rdf.rhea-db.org/23126 rh:products; rh:containsN/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:14802"", ""source_assertion"": ""The substrate side includes CHEBI:58272."", ""source_locator"": ""http://rdf.rhea-db.org/14802 rh:substrates; rh:containsN/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14802"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADP"", ""url"": ""https://www.rhea-db.org/rhea/14802""}, {""id"": ""RHEA:23126"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23126""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-081_b8b0094f0690	MetaCyc:CPLX-105	BFO:0000051	UniProtKB:P54206	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-105|MetaCyc:MONOMER-751	Native coefficient 8; current accession is connected by an explicit native unification cross-reference. Parent PCC6803 and current Kazusa strain are not made identical. Assembly is the source-described state, not invariant under every condition.	"[{""reference_id"": ""MetaCyc:CPLX-105"", ""source_assertion"": ""The complex lists MONOMER-751 with coefficient 8."", ""source_locator"": ""/ptools-xml/Protein/component""}, {""reference_id"": ""MetaCyc:MONOMER-751"", ""source_assertion"": ""The monomer explicitly carries UNIPROT unification cross-reference P54206."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\""]""}]"	"[{""id"": ""MetaCyc:CPLX-105"", ""source_sha256"": ""d5874c642a990903d28cb9f795a2ebe879334d62513ab13cc82f41f3f6a411eb"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""ribulose bisphosphate carboxylase/oxygenase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPLX-105""}, {""id"": ""MetaCyc:MONOMER-751"", ""source_sha256"": ""5904c495034deab23e88182811d188bc38aa6f956a9ffad0c043adb53a79b239"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""CbbS"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:MONOMER-751""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-082_a0316073f64f	MetaCyc:CPLX-7223	BFO:0000051	UniProtKB:P54205	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7223|MetaCyc:MONOMER-750	Native coefficient 2; current accession is connected by an explicit native unification cross-reference. Parent PCC6803 and current Kazusa strain are not made identical. Assembly is the source-described state, not invariant under every condition.	"[{""reference_id"": ""MetaCyc:CPLX-7223"", ""source_assertion"": ""The complex lists MONOMER-750 with coefficient 2."", ""source_locator"": ""/ptools-xml/Protein/component""}, {""reference_id"": ""MetaCyc:MONOMER-750"", ""source_assertion"": ""The monomer explicitly carries UNIPROT unification cross-reference P54205."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\""]""}]"	"[{""id"": ""MetaCyc:CPLX-7223"", ""source_sha256"": ""05d1310a88d4b6fe30ebc7440b86b3d3245b52bbba8c2b0886cd129f0e7e8eb8"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""Cbbl dimer"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPLX-7223""}, {""id"": ""MetaCyc:MONOMER-750"", ""source_sha256"": ""c3be69eb29a5e459224b5680e2f0a7c20db38c80d7ff22a50c9a36297fe12d5c"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""CbbL"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:MONOMER-750""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-083_27dc05bc624b	MetaCyc:CPLX-162	BFO:0000051	UniProtKB:P73922	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.2210/pdb3RPL/pdb|MetaCyc:CPLX-162|MetaCyc:FBPSBP-MONOMER|PMID:24286336	Native coefficient 4; current accession is connected by an explicit native unification cross-reference. Parent PCC6803 and current Kazusa strain are not made identical. Assembly is the source-described state, not invariant under every condition.	"[{""reference_id"": ""MetaCyc:CPLX-162"", ""source_assertion"": ""The complex lists FBPSBP-MONOMER with coefficient 4."", ""source_locator"": ""/ptools-xml/Protein/component""}, {""reference_id"": ""MetaCyc:FBPSBP-MONOMER"", ""source_assertion"": ""The monomer explicitly carries UNIPROT unification cross-reference P73922."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""PMID:24286336"", ""source_assertion"": ""The protein changes between inactive dimer, inactive AMP-bound tetramer and active metal/DTT-associated tetramer; structures include 3RPL."", ""source_locator"": ""Database; Results: Molecular details of the interaction between cy-FBP/SBPase and DTT or Mg2+; Figure 3""}, {""reference_id"": ""DOI:10.2210/pdb3RPL/pdb"", ""source_assertion"": ""Entity 1 has an engineered N-terminal tag and a 344-residue core exactly matching P73922 residues 2–345; source organism is parent PCC6803, not explicitly Kazusa."", ""source_locator"": ""/entity_poly/pdbx_seq_one_letter_code_can; /rcsb_entity_source_organism; /rcsb_polymer_entity_align""}]"	"[{""id"": ""DOI:10.2210/pdb3RPL/pdb"", ""source_sha256"": ""a4b42d6f9116778049a90a664858f6c20bb0d005266bb7c2c6d4f71473e66446"", ""source_version"": ""Original RCSB polymer_entity/3RPL/1 JSON; sequence and source fields only, not the full paper or assembly endpoint"", ""title"": ""3RPL polymer entity 1: engineered PCC6803 FBP/SBPase"", ""url"": ""https://data.rcsb.org/rest/v1/core/polymer_entity/3RPL/1""}, {""id"": ""MetaCyc:CPLX-162"", ""source_sha256"": ""f181d17be40250462a37fbdda28c0971f666a893cb0514b013c6a62cdf09b4ec"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPLX-162""}, {""id"": ""MetaCyc:FBPSBP-MONOMER"", ""source_sha256"": ""7e0b8d44508565912ee5e00aad8b7a6ba0b50f4c972bb85c9986da39cc83ef07"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""fructose bisphosphatase F-I monomer"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:FBPSBP-MONOMER""}, {""id"": ""PMID:24286336"", ""source_version"": ""Full original official article inspected through web; local response 403 retained separately. No full-text byte hash or offline article replay is claimed"", ""title"": ""Structural and biochemical characterization of fructose-1,6/sedoheptulose-1,7-bisphosphatase from the cyanobacterium Synechocystis strain 6803"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.12657""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-084_95891c2a6b6e	MetaCyc:CPLX-143	BFO:0000051	UniProtKB:P74324	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-143|MetaCyc:FBPSYN-MONOMER	Native coefficient 4; current accession is connected by an explicit native unification cross-reference. Parent PCC6803 and current Kazusa strain are not made identical. Assembly is the source-described state, not invariant under every condition.	"[{""reference_id"": ""MetaCyc:CPLX-143"", ""source_assertion"": ""The complex lists FBPSYN-MONOMER with coefficient 4."", ""source_locator"": ""/ptools-xml/Protein/component""}, {""reference_id"": ""MetaCyc:FBPSYN-MONOMER"", ""source_assertion"": ""The monomer explicitly carries UNIPROT unification cross-reference P74324."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\""]""}]"	"[{""id"": ""MetaCyc:CPLX-143"", ""source_sha256"": ""48a45552ec5a84308614491038c9baa98c9bcc5b8ab17c4eaafb311f6b845b60"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""fructose-1,6-bisphosphatase class 1"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPLX-143""}, {""id"": ""MetaCyc:FBPSYN-MONOMER"", ""source_sha256"": ""0f6dbc46b7c9d82c11ad01724669883e3cf14bb77dbacadda35c3318f8e3e85f"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""Fbp"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:FBPSYN-MONOMER""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-085_5e946f1fa49e	MetaCyc:CPLX-9465	BFO:0000051	UniProtKB:Q55664	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-9465|MetaCyc:FBAASYN-MONOMER|PMID:12668779	Native coefficient 8; current accession is connected by an explicit native unification cross-reference. Parent PCC6803 and current Kazusa strain are not made identical. Assembly is the source-described state, not invariant under every condition.	"[{""reference_id"": ""MetaCyc:CPLX-9465"", ""source_assertion"": ""The complex lists FBAASYN-MONOMER with coefficient 8."", ""source_locator"": ""/ptools-xml/Protein/component""}, {""reference_id"": ""MetaCyc:FBAASYN-MONOMER"", ""source_assertion"": ""The monomer explicitly carries UNIPROT unification cross-reference Q55664."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""PMID:12668779"", ""source_assertion"": ""Native apparent masses support class-I dimer and class-II octamer; short N-terminal peptides identify the two genes, not complete current sequences."", ""source_locator"": ""p.327 Purification of FBAs from Synechocystis sp. PCC6803; p.327 apparent molecular masses and N-terminal sequences""}]"	"[{""id"": ""MetaCyc:CPLX-9465"", ""source_sha256"": ""1c15e88945398d4482e0b00a4d17071849c15b86e301f7fe64257d4011ef619a"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""class II fructose-bisphosphate aldolase/sedoheptulose-1,7-bisphosphate aldolase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPLX-9465""}, {""id"": ""MetaCyc:FBAASYN-MONOMER"", ""source_sha256"": ""014a5d9481aabd080e6bc667cfe7702e5e32fd48a2fc53f6531f8f63a7e91f84"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""class II fructose-bisphosphate aldolase/sedoheptulose-1,7-bisphosphate aldolase monomer"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:FBAASYN-MONOMER""}, {""id"": ""PMID:12668779"", ""source_version"": ""Full original article inspected in author-uploaded ResearchGate web rendering; official local PDF returned 403. No full-text byte hash or offline article replay is claimed"", ""title"": ""Purification and Characterization of Class-I and Class-II Fructose-1,6-bisphosphate Aldolases from the Cyanobacterium Synechocystis sp. PCC 6803"", ""url"": ""https://doi.org/10.1093/pcp/pcg044""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-086_164d6a59b133	MetaCyc:CPLX-9466	BFO:0000051	UniProtKB:P74309	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-9466|MetaCyc:FBABSYN-MONOMER|PMID:12668779	Native coefficient 2; current accession is connected by an explicit native unification cross-reference. Parent PCC6803 and current Kazusa strain are not made identical. Assembly is the source-described state, not invariant under every condition.	"[{""reference_id"": ""MetaCyc:CPLX-9466"", ""source_assertion"": ""The complex lists FBABSYN-MONOMER with coefficient 2."", ""source_locator"": ""/ptools-xml/Protein/component""}, {""reference_id"": ""MetaCyc:FBABSYN-MONOMER"", ""source_assertion"": ""The monomer explicitly carries UNIPROT unification cross-reference P74309."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""PMID:12668779"", ""source_assertion"": ""Native apparent masses support class-I dimer and class-II octamer; short N-terminal peptides identify the two genes, not complete current sequences."", ""source_locator"": ""p.327 Purification of FBAs from Synechocystis sp. PCC6803; p.327 apparent molecular masses and N-terminal sequences""}]"	"[{""id"": ""MetaCyc:CPLX-9466"", ""source_sha256"": ""f78aeeca4d232c418d0fe667f40505877cadf7824ba6ff499fa9645f22721208"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""class I fructose-bisphosphate aldolase/sedoheptulose-1,7-bisphosphate aldolase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPLX-9466""}, {""id"": ""MetaCyc:FBABSYN-MONOMER"", ""source_sha256"": ""7cd3aa111c7e0a65397196794d31ce694b64e8ab40c3569a651dbe12e63a9881"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""class I fructose-bisphosphate aldolase/sedoheptulose-1,7-bisphosphate aldolase monomer"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:FBABSYN-MONOMER""}, {""id"": ""PMID:12668779"", ""source_version"": ""Full original article inspected in author-uploaded ResearchGate web rendering; official local PDF returned 403. No full-text byte hash or offline article replay is claimed"", ""title"": ""Purification and Characterization of Class-I and Class-II Fructose-1,6-bisphosphate Aldolases from the Cyanobacterium Synechocystis sp. PCC 6803"", ""url"": ""https://doi.org/10.1093/pcp/pcg044""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-087_2dd6632c2588	MetaCyc:CPLX-105	BFO:0000051	MetaCyc:CPLX-7223	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-105	Four large-chain dimers plus eight small chains constitute the native Rubisco assembly convention.	"[{""reference_id"": ""MetaCyc:CPLX-105"", ""source_assertion"": ""The Rubisco complex lists CPLX-7223 with coefficient 4."", ""source_locator"": ""/ptools-xml/Protein/component""}]"	"[{""id"": ""MetaCyc:CPLX-105"", ""source_sha256"": ""d5874c642a990903d28cb9f795a2ebe879334d62513ab13cc82f41f3f6a411eb"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""ribulose bisphosphate carboxylase/oxygenase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPLX-105""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-088_2e53e2b3bbc4	MetaCyc:CPLX-105	pathwaymech:catalyzes	RHEA:23126	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-122|RHEA:23126	Native enzyme/activity association; cycle direction follows the pathway layout and original Rhea sides. Alternative bifunctional isoforms are not serial requirements.	"[{""reference_id"": ""MetaCyc:ENZRXN-122"", ""source_assertion"": ""The native activity object names this enzyme and reaction, retaining its declared direction and evidence. It is a curated activity association, not a new accession-specific experiment."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction""}, {""reference_id"": ""RHEA:23126"", ""source_assertion"": ""The selected Rhea direction supplies the explicit chemical equation; this citation alone does not identify an organism-specific catalyst."", ""source_locator"": ""http://rdf.rhea-db.org/23126 rh:substrates, rh:products""}]"	"[{""id"": ""MetaCyc:ENZRXN-122"", ""source_sha256"": ""7157f3548299df8a064740958df8356c81f6947a7f45033ed6d93ea2837da65b"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""ribulose bisphosphate carboxylase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:ENZRXN-122""}, {""id"": ""RHEA:23126"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 1,5-bisphosphate + CO2 + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23126""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-089_11dd3ea0e6f2	MetaCyc:CPLX-162	pathwaymech:catalyzes	RHEA:17462	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-182|PMID:24286336|RHEA:17462	Native enzyme/activity association; cycle direction follows the pathway layout and original Rhea sides. Alternative bifunctional isoforms are not serial requirements.	"[{""reference_id"": ""MetaCyc:ENZRXN-182"", ""source_assertion"": ""The native activity object names this enzyme and reaction, retaining its declared direction and evidence. It is a curated activity association, not a new accession-specific experiment."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction""}, {""reference_id"": ""RHEA:17462"", ""source_assertion"": ""The selected Rhea direction supplies the explicit chemical equation; this citation alone does not identify an organism-specific catalyst."", ""source_locator"": ""http://rdf.rhea-db.org/17462 rh:substrates, rh:products""}, {""reference_id"": ""PMID:24286336"", ""source_assertion"": ""The recombinant enzyme hydrolyzed both FBP and SBP in magnesium-containing assays. Culture substrain and engineered preparation remain qualified."", ""source_locator"": ""Results: Molecular details of the interaction between cy-FBP/SBPase and FBP; Table 2; Experimental procedures: Phosphatase activity assays""}]"	"[{""id"": ""MetaCyc:ENZRXN-182"", ""source_sha256"": ""2262e24ffb69114a04e48fd06cce54ff75b0fa5a2cc98b07c1a21c668a612b6e"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""sedoheptulose bisphosphatase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:ENZRXN-182""}, {""id"": ""PMID:24286336"", ""source_version"": ""Full original official article inspected through web; local response 403 retained separately. No full-text byte hash or offline article replay is claimed"", ""title"": ""Structural and biochemical characterization of fructose-1,6/sedoheptulose-1,7-bisphosphatase from the cyanobacterium Synechocystis strain 6803"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.12657""}, {""id"": ""RHEA:17462"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 1,7-bisphosphate + H2O => D-sedoheptulose 7-phosphate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/17462""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-090_a1725ff8476b	MetaCyc:CPLX-162	pathwaymech:catalyzes	RHEA:11065	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-183|PMID:24286336|RHEA:11065	Native enzyme/activity association; cycle direction follows the pathway layout and original Rhea sides. Alternative bifunctional isoforms are not serial requirements.	"[{""reference_id"": ""MetaCyc:ENZRXN-183"", ""source_assertion"": ""The native activity object names this enzyme and reaction, retaining its declared direction and evidence. It is a curated activity association, not a new accession-specific experiment."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction""}, {""reference_id"": ""RHEA:11065"", ""source_assertion"": ""The selected Rhea direction supplies the explicit chemical equation; this citation alone does not identify an organism-specific catalyst."", ""source_locator"": ""http://rdf.rhea-db.org/11065 rh:substrates, rh:products""}, {""reference_id"": ""PMID:24286336"", ""source_assertion"": ""The recombinant enzyme hydrolyzed both FBP and SBP in magnesium-containing assays. Culture substrain and engineered preparation remain qualified."", ""source_locator"": ""Results: Molecular details of the interaction between cy-FBP/SBPase and FBP; Table 2; Experimental procedures: Phosphatase activity assays""}]"	"[{""id"": ""MetaCyc:ENZRXN-183"", ""source_sha256"": ""9d68d634e22fb6a9cdce3f02d0505a9f54c287b4717181effc6dcdcbca51e7cf"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""fructose 1,6-bisphosphatase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:ENZRXN-183""}, {""id"": ""PMID:24286336"", ""source_version"": ""Full original official article inspected through web; local response 403 retained separately. No full-text byte hash or offline article replay is claimed"", ""title"": ""Structural and biochemical characterization of fructose-1,6/sedoheptulose-1,7-bisphosphatase from the cyanobacterium Synechocystis strain 6803"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.12657""}, {""id"": ""RHEA:11065"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/11065""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-091_c1842625ed76	MetaCyc:CPLX-143	pathwaymech:catalyzes	RHEA:11065	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-169|RHEA:11065	Native enzyme/activity association; cycle direction follows the pathway layout and original Rhea sides. Alternative bifunctional isoforms are not serial requirements.	"[{""reference_id"": ""MetaCyc:ENZRXN-169"", ""source_assertion"": ""The native activity object names this enzyme and reaction, retaining its declared direction and evidence. It is a curated activity association, not a new accession-specific experiment."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction""}, {""reference_id"": ""RHEA:11065"", ""source_assertion"": ""The selected Rhea direction supplies the explicit chemical equation; this citation alone does not identify an organism-specific catalyst."", ""source_locator"": ""http://rdf.rhea-db.org/11065 rh:substrates, rh:products""}]"	"[{""id"": ""MetaCyc:ENZRXN-169"", ""source_sha256"": ""8c8ab8f0a7cf322f6e6667c2788505a6181f769aca7c4771e57de630c850a80c"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""fructose 1,6-bisphosphatase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:ENZRXN-169""}, {""id"": ""RHEA:11065"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/11065""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-092_8c4fc3c1fcee	MetaCyc:CPLX-9465	pathwaymech:catalyzes	RHEA:30168	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-163|PMID:12668779|RHEA:30168	Native enzyme/activity association; cycle direction follows the pathway layout and original Rhea sides. Alternative bifunctional isoforms are not serial requirements.	"[{""reference_id"": ""MetaCyc:ENZRXN-163"", ""source_assertion"": ""The native activity object names this enzyme and reaction, retaining its declared direction and evidence. It is a curated activity association, not a new accession-specific experiment."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction""}, {""reference_id"": ""RHEA:30168"", ""source_assertion"": ""The selected Rhea direction supplies the explicit chemical equation; this citation alone does not identify an organism-specific catalyst."", ""source_locator"": ""http://rdf.rhea-db.org/30168 rh:substrates, rh:products""}, {""reference_id"": ""PMID:12668779"", ""source_assertion"": ""The Synechocystis class-I/II enzymes cleave FBP and SBP. Native class-I remained partly purified; its kinetic characterization used purified recombinant enzyme."", ""source_locator"": ""pp.328–329: Kinetic properties of enzymatic reactions of FBAs; Reactivities of FBAs from various organisms for FBP and SBP; Table 4; p.331 Assay of FBA""}]"	"[{""id"": ""MetaCyc:ENZRXN-163"", ""source_sha256"": ""63bd23a5a8584a068e7d07955b149cbcc2f13ea2640a2a37dc313004c4da027c"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""sedoheptulose-1,7-bisphosphate aldolase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:ENZRXN-163""}, {""id"": ""PMID:12668779"", ""source_version"": ""Full original article inspected in author-uploaded ResearchGate web rendering; official local PDF returned 403. No full-text byte hash or offline article replay is claimed"", ""title"": ""Purification and Characterization of Class-I and Class-II Fructose-1,6-bisphosphate Aldolases from the Cyanobacterium Synechocystis sp. PCC 6803"", ""url"": ""https://doi.org/10.1093/pcp/pcg044""}, {""id"": ""RHEA:30168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphate"", ""url"": ""https://www.rhea-db.org/rhea/30168""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-093_b32a01cc1e83	MetaCyc:CPLX-9465	pathwaymech:catalyzes	RHEA:14731	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-164|PMID:12668779|RHEA:14731	Native enzyme/activity association; cycle direction follows the pathway layout and original Rhea sides. Alternative bifunctional isoforms are not serial requirements.	"[{""reference_id"": ""MetaCyc:ENZRXN-164"", ""source_assertion"": ""The native activity object names this enzyme and reaction, retaining its declared direction and evidence. It is a curated activity association, not a new accession-specific experiment."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction""}, {""reference_id"": ""RHEA:14731"", ""source_assertion"": ""The selected Rhea direction supplies the explicit chemical equation; this citation alone does not identify an organism-specific catalyst."", ""source_locator"": ""http://rdf.rhea-db.org/14731 rh:substrates, rh:products""}, {""reference_id"": ""PMID:12668779"", ""source_assertion"": ""The Synechocystis class-I/II enzymes cleave FBP and SBP. Native class-I remained partly purified; its kinetic characterization used purified recombinant enzyme."", ""source_locator"": ""pp.328–329: Kinetic properties of enzymatic reactions of FBAs; Reactivities of FBAs from various organisms for FBP and SBP; Table 4; p.331 Assay of FBA""}]"	"[{""id"": ""MetaCyc:ENZRXN-164"", ""source_sha256"": ""43b2b6c55c8c99ed902d7f5c0bf07f48a319c7595828b84260bcabe6dbb9d0da"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""fructose-bisphosphate aldolase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:ENZRXN-164""}, {""id"": ""PMID:12668779"", ""source_version"": ""Full original article inspected in author-uploaded ResearchGate web rendering; official local PDF returned 403. No full-text byte hash or offline article replay is claimed"", ""title"": ""Purification and Characterization of Class-I and Class-II Fructose-1,6-bisphosphate Aldolases from the Cyanobacterium Synechocystis sp. PCC 6803"", ""url"": ""https://doi.org/10.1093/pcp/pcg044""}, {""id"": ""RHEA:14731"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate"", ""url"": ""https://www.rhea-db.org/rhea/14731""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-094_17e32203a167	MetaCyc:CPLX-9466	pathwaymech:catalyzes	RHEA:30168	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-165|PMID:12668779|RHEA:30168	Native enzyme/activity association; cycle direction follows the pathway layout and original Rhea sides. Alternative bifunctional isoforms are not serial requirements.	"[{""reference_id"": ""MetaCyc:ENZRXN-165"", ""source_assertion"": ""The native activity object names this enzyme and reaction, retaining its declared direction and evidence. It is a curated activity association, not a new accession-specific experiment."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction""}, {""reference_id"": ""RHEA:30168"", ""source_assertion"": ""The selected Rhea direction supplies the explicit chemical equation; this citation alone does not identify an organism-specific catalyst."", ""source_locator"": ""http://rdf.rhea-db.org/30168 rh:substrates, rh:products""}, {""reference_id"": ""PMID:12668779"", ""source_assertion"": ""The Synechocystis class-I/II enzymes cleave FBP and SBP. Native class-I remained partly purified; its kinetic characterization used purified recombinant enzyme."", ""source_locator"": ""pp.328–329: Kinetic properties of enzymatic reactions of FBAs; Reactivities of FBAs from various organisms for FBP and SBP; Table 4; p.331 Assay of FBA""}]"	"[{""id"": ""MetaCyc:ENZRXN-165"", ""source_sha256"": ""d94ff683c6e26db2d55605e74dc1976337071c420387232b71a445af66820ba7"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""sedoheptulose-1,7-bisphosphate aldolase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:ENZRXN-165""}, {""id"": ""PMID:12668779"", ""source_version"": ""Full original article inspected in author-uploaded ResearchGate web rendering; official local PDF returned 403. No full-text byte hash or offline article replay is claimed"", ""title"": ""Purification and Characterization of Class-I and Class-II Fructose-1,6-bisphosphate Aldolases from the Cyanobacterium Synechocystis sp. PCC 6803"", ""url"": ""https://doi.org/10.1093/pcp/pcg044""}, {""id"": ""RHEA:30168"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphate"", ""url"": ""https://www.rhea-db.org/rhea/30168""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-095_56232d6049c0	MetaCyc:CPLX-9466	pathwaymech:catalyzes	RHEA:14731	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-166|PMID:12668779|RHEA:14731	Native enzyme/activity association; cycle direction follows the pathway layout and original Rhea sides. Alternative bifunctional isoforms are not serial requirements.	"[{""reference_id"": ""MetaCyc:ENZRXN-166"", ""source_assertion"": ""The native activity object names this enzyme and reaction, retaining its declared direction and evidence. It is a curated activity association, not a new accession-specific experiment."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction""}, {""reference_id"": ""RHEA:14731"", ""source_assertion"": ""The selected Rhea direction supplies the explicit chemical equation; this citation alone does not identify an organism-specific catalyst."", ""source_locator"": ""http://rdf.rhea-db.org/14731 rh:substrates, rh:products""}, {""reference_id"": ""PMID:12668779"", ""source_assertion"": ""The Synechocystis class-I/II enzymes cleave FBP and SBP. Native class-I remained partly purified; its kinetic characterization used purified recombinant enzyme."", ""source_locator"": ""pp.328–329: Kinetic properties of enzymatic reactions of FBAs; Reactivities of FBAs from various organisms for FBP and SBP; Table 4; p.331 Assay of FBA""}]"	"[{""id"": ""MetaCyc:ENZRXN-166"", ""source_sha256"": ""f6b5e13013514af45f3f4cd744ff63e4b7000f40b5d80cb81e377efb7c71e99c"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""fructose-bisphosphate aldolase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:ENZRXN-166""}, {""id"": ""PMID:12668779"", ""source_version"": ""Full original article inspected in author-uploaded ResearchGate web rendering; official local PDF returned 403. No full-text byte hash or offline article replay is claimed"", ""title"": ""Purification and Characterization of Class-I and Class-II Fructose-1,6-bisphosphate Aldolases from the Cyanobacterium Synechocystis sp. PCC 6803"", ""url"": ""https://doi.org/10.1093/pcp/pcg044""}, {""id"": ""RHEA:14731"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate"", ""url"": ""https://www.rhea-db.org/rhea/14731""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-096_9bb850e76280	MetaCyc:TKTASYN-MONOMER	pathwaymech:catalyzes	RHEA:10509	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-168|PMID:37723200|RHEA:10509	Native transketolase activity only. Its exact mapping to current P73282 remains unestablished; the 2023 surrogate-donor assay does not demonstrate this canonical substrate pair.	"[{""reference_id"": ""MetaCyc:ENZRXN-168"", ""source_assertion"": ""The native object names TKTASYN-MONOMER and its reaction, is reversible and physiologically relevant, and has no experimental evidence or publication element."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction""}, {""reference_id"": ""RHEA:10509"", ""source_assertion"": ""The selected Rhea direction supplies the explicit chemical equation; this citation alone does not identify an organism-specific catalyst."", ""source_locator"": ""http://rdf.rhea-db.org/10509 rh:substrates, rh:products""}, {""reference_id"": ""PMID:37723200"", ""source_assertion"": ""The 2023 assay used ribose 5-phosphate with L-erythrulose as donor. It does not directly test this canonical substrate pair."", ""source_locator"": ""//p[@id=\""Par53\""]""}]"	"[{""id"": ""MetaCyc:ENZRXN-168"", ""source_sha256"": ""07484a1d66ab55740526e9d9565a930e7bbc485090ed756949492e1e73f423ee"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycoaldehyde transferase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:ENZRXN-168""}, {""id"": ""PMID:37723200"", ""source_sha256"": ""daf158707f78a74ff507ec5fbda0f767df239aea8cf41b0bdda2a7298d633109"", ""source_version"": ""Original full primary JATS; native PCC6803 genomic construct and surrogate-donor assay distinguished"", ""title"": ""Metabolite interactions in the bacterial Calvin cycle and implications for flux regulation"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC10507043/""}, {""id"": ""RHEA:10509"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/10509""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-097_b364f001f300	MetaCyc:TKTASYN-MONOMER	pathwaymech:catalyzes	RHEA:27628	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-167|PMID:37723200|RHEA:27628	Native transketolase activity only. Its exact mapping to current P73282 remains unestablished; the 2023 surrogate-donor assay does not demonstrate this canonical substrate pair.	"[{""reference_id"": ""MetaCyc:ENZRXN-167"", ""source_assertion"": ""The native object names TKTASYN-MONOMER and its reaction, is reversible and physiologically relevant, and has no experimental evidence or publication element."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction""}, {""reference_id"": ""RHEA:27628"", ""source_assertion"": ""The selected Rhea direction supplies the explicit chemical equation; this citation alone does not identify an organism-specific catalyst."", ""source_locator"": ""http://rdf.rhea-db.org/27628 rh:substrates, rh:products""}, {""reference_id"": ""PMID:37723200"", ""source_assertion"": ""The 2023 assay used ribose 5-phosphate with L-erythrulose as donor. It does not directly test this canonical substrate pair."", ""source_locator"": ""//p[@id=\""Par53\""]""}]"	"[{""id"": ""MetaCyc:ENZRXN-167"", ""source_sha256"": ""a0b67aa5eedcd0a6742db80c14567a1f78a2da47b8f4902ffc4513d661da6a9e"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""D-fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:ENZRXN-167""}, {""id"": ""PMID:37723200"", ""source_sha256"": ""daf158707f78a74ff507ec5fbda0f767df239aea8cf41b0bdda2a7298d633109"", ""source_version"": ""Original full primary JATS; native PCC6803 genomic construct and surrogate-donor assay distinguished"", ""title"": ""Metabolite interactions in the bacterial Calvin cycle and implications for flux regulation"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC10507043/""}, {""id"": ""RHEA:27628"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/27628""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-098_8c7e101ac0c3	UniProtKB:P37101	pathwaymech:enables	RHEA:19366	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19366|UniProtKB:P37101	Current curated catalytic annotation has no experimental evidence code on this block. Functional protein-level participation does not invent an ungrounded assembly identifier.	"[{""reference_id"": ""UniProtKB:P37101"", ""source_assertion"": ""The current curated catalytic-activity block links RHEA:19365; this block has no experimental evidence code."", ""source_locator"": ""/results/11/comments/0""}, {""reference_id"": ""RHEA:19366"", ""source_assertion"": ""The Rhea master and selected direction preserve the reaction family and cycle polarity."", ""source_locator"": ""http://rdf.rhea-db.org/19365 rh:directionalReaction; http://rdf.rhea-db.org/19366 rh:substrates, rh:products""}]"	"[{""id"": ""RHEA:19366"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-ribulose 5-phosphate + ATP => D-ribulose 1,5-bisphosphate + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/19366""}, {""id"": ""UniProtKB:P37101"", ""source_sha256"": ""bf02300a6a8d6886748f16a3c16d53424f3287abf0c733ab933e37354afc6f77"", ""source_version"": ""Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained"", ""title"": ""Phosphoribulokinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37101.json""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-099_b7e88509bde4	UniProtKB:P74421	pathwaymech:enables	RHEA:14802	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14802|UniProtKB:P74421	Current catalytic annotation; monomer assignment is ECO:0000250 similarity. Functional protein-level participation does not invent an ungrounded assembly identifier.	"[{""reference_id"": ""UniProtKB:P74421"", ""source_assertion"": ""The current curated catalytic-activity block links RHEA:14801; this block has no experimental evidence code."", ""source_locator"": ""/results/8/comments/0""}, {""reference_id"": ""RHEA:14802"", ""source_assertion"": ""The Rhea master and selected direction preserve the reaction family and cycle polarity."", ""source_locator"": ""http://rdf.rhea-db.org/14801 rh:directionalReaction; http://rdf.rhea-db.org/14802 rh:substrates, rh:products""}, {""reference_id"": ""UniProtKB:P74421"", ""source_assertion"": ""The source annotates Monomer; its original evidence code and cited preparation scope are retained."", ""source_locator"": ""/results/8/comments/2""}]"	"[{""id"": ""RHEA:14802"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADP"", ""url"": ""https://www.rhea-db.org/rhea/14802""}, {""id"": ""UniProtKB:P74421"", ""source_sha256"": ""bf02300a6a8d6886748f16a3c16d53424f3287abf0c733ab933e37354afc6f77"", ""source_version"": ""Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained"", ""title"": ""Phosphoglycerate kinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P74421.json""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-100_d1ee60ea20c3	UniProtKB:P80505	pathwaymech:enables	RHEA:10298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9226260|RHEA:10298|UniProtKB:P80505	Current activity is ECO:0000269/PMID9226260; the native cycle uses the reductive NADPH direction. Homotetramer and dual-cofactor evidence remain preparation-scoped. Functional protein-level participation does not invent an ungrounded assembly identifier.	"[{""reference_id"": ""UniProtKB:P80505"", ""source_assertion"": ""The NADP-dependent catalytic activity links RHEA:10296 with ECO:0000269 and PMID9226260."", ""source_locator"": ""/results/0/comments/1""}, {""reference_id"": ""RHEA:10298"", ""source_assertion"": ""The Rhea master and selected direction preserve the reaction family and cycle polarity."", ""source_locator"": ""http://rdf.rhea-db.org/10296 rh:directionalReaction; http://rdf.rhea-db.org/10298 rh:substrates, rh:products""}, {""reference_id"": ""UniProtKB:P80505"", ""source_assertion"": ""The source annotates Homotetramer; its original evidence code and cited preparation scope are retained."", ""source_locator"": ""/results/0/comments/4""}, {""reference_id"": ""PMID:9226260"", ""source_assertion"": ""The abstract identifies native and recombinant Gap2 as 337-residue homotetramers with NAD- and NADP-dependent activities; genomic complementation identified the gene."", ""source_locator"": ""//section[@id=\""abstract1\""]""}]"	"[{""id"": ""PMID:9226260"", ""source_sha256"": ""1b3d9cc43fe6cabee27bebe05fa8dbf163754b43ae83ae4aba379f9a8e0e98f8"", ""source_version"": ""Original primary abstract HTML inspected; PDF request returned preparation HTML, not a retained full primary PDF"", ""title"": ""Functional complementation of an Escherichia coli gap mutant supports an amphibolic role for NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase of Synechocystis sp. strain PCC 6803."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC179286/""}, {""id"": ""RHEA:10298"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""(2R)-3-phospho-glyceroyl phosphate + NADPH + H(+) => D-glyceraldehyde 3-phosphate + phosphate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/10298""}, {""id"": ""UniProtKB:P80505"", ""source_sha256"": ""bf02300a6a8d6886748f16a3c16d53424f3287abf0c733ab933e37354afc6f77"", ""source_version"": ""Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained"", ""title"": ""Glyceraldehyde-3-phosphate dehydrogenase 2"", ""url"": ""https://rest.uniprot.org/uniprotkb/P80505.json""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-101_370a5b33338d	UniProtKB:Q59994	pathwaymech:enables	RHEA:18586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:TPIASYN-MONOMER|RHEA:18586|UniProtKB:Q59994|UniProtKB:Q95554	HAMAP ECO:0000255 activity and homodimer inference. Native TPIASYN-MONOMER points to unrelated mouse Q95554, so no native-complex equivalence is used. Functional protein-level participation does not invent an ungrounded assembly identifier.	"[{""reference_id"": ""UniProtKB:Q59994"", ""source_assertion"": ""The activity links RHEA:18585 with HAMAP ECO:0000255."", ""source_locator"": ""/results/9/comments/1""}, {""reference_id"": ""RHEA:18586"", ""source_assertion"": ""The Rhea master and selected direction preserve the reaction family and cycle polarity."", ""source_locator"": ""http://rdf.rhea-db.org/18585 rh:directionalReaction; http://rdf.rhea-db.org/18586 rh:substrates, rh:products""}, {""reference_id"": ""UniProtKB:Q59994"", ""source_assertion"": ""The source annotates Homodimer; its original evidence code and cited preparation scope are retained."", ""source_locator"": ""/results/9/comments/4""}, {""reference_id"": ""MetaCyc:TPIASYN-MONOMER"", ""source_assertion"": ""The native PCC6803 TpiA frame links UNIPROT Q95554."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\""] | /ptools-xml/Protein/species""}, {""reference_id"": ""UniProtKB:Q95554"", ""source_assertion"": ""The issuing entry is a 21-residue Mus musculus MHC fragment and reciprocally lists the native TPI frame. Reciprocal links alone therefore do not establish biological equivalence."", ""source_locator"": ""/primaryAccession; /organism; /proteinDescription; /sequence; /uniProtKBCrossReferences""}]"	"[{""id"": ""MetaCyc:TPIASYN-MONOMER"", ""source_sha256"": ""aed3584cbdc1dfb7d789dc5f192cf142a93590a66038b4af30b4fcdaf1f0352f"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""TpiA"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:TPIASYN-MONOMER""}, {""id"": ""RHEA:18586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphate"", ""url"": ""https://www.rhea-db.org/rhea/18586""}, {""id"": ""UniProtKB:Q59994"", ""source_sha256"": ""bf02300a6a8d6886748f16a3c16d53424f3287abf0c733ab933e37354afc6f77"", ""source_version"": ""Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained"", ""title"": ""Triosephosphate isomerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q59994.json""}, {""id"": ""UniProtKB:Q95554"", ""source_sha256"": ""3852f125a33dc247b3c321de9b32e51c5c9f3ef1dbb9ede65e2cdc9ca7911c41"", ""source_version"": ""Original current unreviewed mouse fragment JSON; inspected solely to reject a wrong reciprocal native cross-reference"", ""title"": ""Major histocompatibility complex antigen H-2Kbm29"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q95554.json""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-102_f67683f88ba4	UniProtKB:Q55766	pathwaymech:enables	RHEA:14658	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14658|UniProtKB:Q55766	HAMAP ECO:0000255 activity and homodimer inference; aldehydo substrate is a refinement of the native ribose-phosphate class. Functional protein-level participation does not invent an ungrounded assembly identifier.	"[{""reference_id"": ""UniProtKB:Q55766"", ""source_assertion"": ""The aldehydo-D-ribose 5-phosphate activity links RHEA:14657 with HAMAP ECO:0000255."", ""source_locator"": ""/results/7/comments/1""}, {""reference_id"": ""RHEA:14658"", ""source_assertion"": ""The Rhea master and selected direction preserve the reaction family and cycle polarity."", ""source_locator"": ""http://rdf.rhea-db.org/14657 rh:directionalReaction; http://rdf.rhea-db.org/14658 rh:substrates, rh:products""}, {""reference_id"": ""UniProtKB:Q55766"", ""source_assertion"": ""The source annotates Homodimer; its original evidence code and cited preparation scope are retained."", ""source_locator"": ""/results/7/comments/3""}]"	"[{""id"": ""RHEA:14658"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/14658""}, {""id"": ""UniProtKB:Q55766"", ""source_sha256"": ""bf02300a6a8d6886748f16a3c16d53424f3287abf0c733ab933e37354afc6f77"", ""source_version"": ""Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained"", ""title"": ""Ribose-5-phosphate isomerase A"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q55766.json""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-103_d838d29ad5d7	UniProtKB:P74061	pathwaymech:enables	RHEA:13679	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:15333955|RHEA:13679|UniProtKB:P74061	HAMAP ECO:0000255 activity; homohexamer annotation separately cites PMID15333955. Functional protein-level participation does not invent an ungrounded assembly identifier. The inspected primary abstract reports a crystallographic asymmetric-unit hexamer, not an invariant solution assembly.	"[{""reference_id"": ""UniProtKB:P74061"", ""source_assertion"": ""The reversible ribulose/xylulose-phosphate activity links RHEA:13677 with HAMAP ECO:0000255."", ""source_locator"": ""/results/2/comments/1""}, {""reference_id"": ""RHEA:13679"", ""source_assertion"": ""The Rhea master and selected direction preserve the reaction family and cycle polarity."", ""source_locator"": ""http://rdf.rhea-db.org/13677 rh:directionalReaction; http://rdf.rhea-db.org/13679 rh:substrates, rh:products""}, {""reference_id"": ""UniProtKB:P74061"", ""source_assertion"": ""The source annotates Homohexamer; its original evidence code and cited preparation scope are retained."", ""source_locator"": ""/results/2/comments/4""}, {""reference_id"": ""PMID:15333955"", ""source_assertion"": ""The primary abstract reports a hexamer in the crystallographic asymmetric unit; it does not establish an invariant solution or native assembly."", ""source_locator"": ""/resultList/result/1/abstractText (id=15333955)""}]"	"[{""id"": ""PMID:15333955"", ""source_sha256"": ""c0c45cf7dd7309369b61f29b193e203f746e35460e7fc7d1129a8db56a640332"", ""source_version"": ""Original Europe PMC indexed primary abstract in a retained metadata batch; no full article inspection is claimed"", ""title"": ""Structure of D-ribulose 5-phosphate 3-epimerase from Synechocystis to 1.6 A resolution."", ""url"": ""https://europepmc.org/article/MED/15333955""}, {""id"": ""RHEA:13679"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-xylulose 5-phosphate => D-ribulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/13679""}, {""id"": ""UniProtKB:P74061"", ""source_sha256"": ""bf02300a6a8d6886748f16a3c16d53424f3287abf0c733ab933e37354afc6f77"", ""source_version"": ""Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained"", ""title"": ""Ribulose-phosphate 3-epimerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P74061.json""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-104_050472123912	UniProtKB:P73282	pathwaymech:enables	RHEA:10509	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10509|UniProtKB:P73282	Unreviewed ARBA/RuleBase ECO:0000256 activity. This is a current annotation, not proof of native TKTASYN identity or of the second canonical substrate pair. Functional protein-level participation does not invent an ungrounded assembly identifier.	"[{""reference_id"": ""UniProtKB:P73282"", ""source_assertion"": ""The activity links RHEA:10508 with automated ARBA/RuleBase ECO:0000256."", ""source_locator"": ""/results/12/comments/1""}, {""reference_id"": ""RHEA:10509"", ""source_assertion"": ""The Rhea master and selected direction preserve the reaction family and cycle polarity."", ""source_locator"": ""http://rdf.rhea-db.org/10508 rh:directionalReaction; http://rdf.rhea-db.org/10509 rh:substrates, rh:products""}, {""reference_id"": ""UniProtKB:P73282"", ""source_assertion"": ""The source annotates Homodimer; its original evidence code and cited preparation scope are retained."", ""source_locator"": ""/results/12/comments/9""}]"	"[{""id"": ""RHEA:10509"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 original complete compressed RDF; approved directional reaction and exact sides"", ""title"": ""D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate"", ""url"": ""https://www.rhea-db.org/rhea/10509""}, {""id"": ""UniProtKB:P73282"", ""source_sha256"": ""bf02300a6a8d6886748f16a3c16d53424f3287abf0c733ab933e37354afc6f77"", ""source_version"": ""Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained"", ""title"": ""Transketolase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P73282.json""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-105_0fb204ae73f2	UniProtKB:P54205	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P54205	HAMAP ECO:0000255; one magnesium ion per large subunit.	"[{""reference_id"": ""UniProtKB:P54205"", ""source_assertion"": ""HAMAP ECO:0000255; one magnesium ion per large subunit."", ""source_locator"": ""/results/3/comments/3""}]"	"[{""id"": ""UniProtKB:P54205"", ""source_sha256"": ""bf02300a6a8d6886748f16a3c16d53424f3287abf0c733ab933e37354afc6f77"", ""source_version"": ""Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained"", ""title"": ""Ribulose bisphosphate carboxylase large chain"", ""url"": ""https://rest.uniprot.org/uniprotkb/P54205.json""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-106_01f3b516462a	UniProtKB:Q55664	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12668779|UniProtKB:Q55664	ECO:0000250 similarity: two Zn ions per subunit. The 2003 primary assay instead used CoCl2; this is not direct physiological Zn determination.	"[{""reference_id"": ""UniProtKB:Q55664"", ""source_assertion"": ""ECO:0000250 similarity: two Zn ions per subunit."", ""source_locator"": ""/results/1/comments/2""}, {""reference_id"": ""PMID:12668779"", ""source_assertion"": ""EDTA-treated class-II enzyme responded most strongly to cobalt; the routine assay used CoCl2. This does not prove physiological zinc occupancy."", ""source_locator"": ""p.328 Kinetic properties of enzymatic reactions of FBAs; p.331 Assay of FBA""}]"	"[{""id"": ""PMID:12668779"", ""source_version"": ""Full original article inspected in author-uploaded ResearchGate web rendering; official local PDF returned 403. No full-text byte hash or offline article replay is claimed"", ""title"": ""Purification and Characterization of Class-I and Class-II Fructose-1,6-bisphosphate Aldolases from the Cyanobacterium Synechocystis sp. PCC 6803"", ""url"": ""https://doi.org/10.1093/pcp/pcg044""}, {""id"": ""UniProtKB:Q55664"", ""source_sha256"": ""bf02300a6a8d6886748f16a3c16d53424f3287abf0c733ab933e37354afc6f77"", ""source_version"": ""Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained"", ""title"": ""Fructose-bisphosphate aldolase class 2"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q55664.json""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-107_50fa684b3968	UniProtKB:P73922	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:24286336|UniProtKB:P73922	ECO:0000250 similarity manganese annotation. Later recombinant assays used magnesium; neither assay condition proves exclusive physiological metal choice.	"[{""reference_id"": ""UniProtKB:P73922"", ""source_assertion"": ""ECO:0000250 similarity manganese annotation."", ""source_locator"": ""/results/4/comments/3""}, {""reference_id"": ""PMID:24286336"", ""source_assertion"": ""Magnesium or manganese with DTT activates the recombinant preparation; this does not establish one exclusive physiological metal."", ""source_locator"": ""Results: Molecular details of the interaction between cy-FBP/SBPase and DTT or Mg2+; Figure 3""}]"	"[{""id"": ""PMID:24286336"", ""source_version"": ""Full original official article inspected through web; local response 403 retained separately. No full-text byte hash or offline article replay is claimed"", ""title"": ""Structural and biochemical characterization of fructose-1,6/sedoheptulose-1,7-bisphosphatase from the cyanobacterium Synechocystis strain 6803"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.12657""}, {""id"": ""UniProtKB:P73922"", ""source_sha256"": ""bf02300a6a8d6886748f16a3c16d53424f3287abf0c733ab933e37354afc6f77"", ""source_version"": ""Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained"", ""title"": ""D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P73922.json""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-108_f5dffcd5241a	UniProtKB:P74324	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P74324	HAMAP ECO:0000255; two magnesium ions per subunit.	"[{""reference_id"": ""UniProtKB:P74324"", ""source_assertion"": ""HAMAP ECO:0000255; two magnesium ions per subunit."", ""source_locator"": ""/results/5/comments/1""}]"	"[{""id"": ""UniProtKB:P74324"", ""source_sha256"": ""bf02300a6a8d6886748f16a3c16d53424f3287abf0c733ab933e37354afc6f77"", ""source_version"": ""Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained"", ""title"": ""Fructose-1,6-bisphosphatase class 1"", ""url"": ""https://rest.uniprot.org/uniprotkb/P74324.json""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-109_4ef70f3a8d57	UniProtKB:P74061	pathwaymech:has_cofactor	CHEBI:60240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P74061	HAMAP ECO:0000255; one generic divalent metal cation per subunit, not a resolved metal identity.	"[{""reference_id"": ""UniProtKB:P74061"", ""source_assertion"": ""HAMAP ECO:0000255; one generic divalent metal cation per subunit, not a resolved metal identity."", ""source_locator"": ""/results/2/comments/2""}]"	"[{""id"": ""UniProtKB:P74061"", ""source_sha256"": ""bf02300a6a8d6886748f16a3c16d53424f3287abf0c733ab933e37354afc6f77"", ""source_version"": ""Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained"", ""title"": ""Ribulose-phosphate 3-epimerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P74061.json""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-110_980430056b17	UniProtKB:P73282	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P73282	ECO:0000256 RuleBase annotation: magnesium and alternative calcium, manganese or cobalt, not simultaneous obligatory occupancy.	"[{""reference_id"": ""UniProtKB:P73282"", ""source_assertion"": ""ECO:0000256 RuleBase annotation: magnesium and alternative calcium, manganese or cobalt, not simultaneous obligatory occupancy."", ""source_locator"": ""/results/12/comments/4""}]"	"[{""id"": ""UniProtKB:P73282"", ""source_sha256"": ""bf02300a6a8d6886748f16a3c16d53424f3287abf0c733ab933e37354afc6f77"", ""source_version"": ""Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained"", ""title"": ""Transketolase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P73282.json""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-111_a6efca186521	UniProtKB:P73282	pathwaymech:has_cofactor	CHEBI:29108	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P73282	ECO:0000256 RuleBase annotation: magnesium and alternative calcium, manganese or cobalt, not simultaneous obligatory occupancy.	"[{""reference_id"": ""UniProtKB:P73282"", ""source_assertion"": ""ECO:0000256 RuleBase annotation: magnesium and alternative calcium, manganese or cobalt, not simultaneous obligatory occupancy."", ""source_locator"": ""/results/12/comments/4""}]"	"[{""id"": ""UniProtKB:P73282"", ""source_sha256"": ""bf02300a6a8d6886748f16a3c16d53424f3287abf0c733ab933e37354afc6f77"", ""source_version"": ""Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained"", ""title"": ""Transketolase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P73282.json""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-112_0c186c1628fe	UniProtKB:P73282	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P73282	ECO:0000256 RuleBase annotation: magnesium and alternative calcium, manganese or cobalt, not simultaneous obligatory occupancy.	"[{""reference_id"": ""UniProtKB:P73282"", ""source_assertion"": ""ECO:0000256 RuleBase annotation: magnesium and alternative calcium, manganese or cobalt, not simultaneous obligatory occupancy."", ""source_locator"": ""/results/12/comments/4""}]"	"[{""id"": ""UniProtKB:P73282"", ""source_sha256"": ""bf02300a6a8d6886748f16a3c16d53424f3287abf0c733ab933e37354afc6f77"", ""source_version"": ""Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained"", ""title"": ""Transketolase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P73282.json""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-113_3e033fefd033	UniProtKB:P73282	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P73282	ECO:0000256 RuleBase annotation: magnesium and alternative calcium, manganese or cobalt, not simultaneous obligatory occupancy.	"[{""reference_id"": ""UniProtKB:P73282"", ""source_assertion"": ""ECO:0000256 RuleBase annotation: magnesium and alternative calcium, manganese or cobalt, not simultaneous obligatory occupancy."", ""source_locator"": ""/results/12/comments/4""}]"	"[{""id"": ""UniProtKB:P73282"", ""source_sha256"": ""bf02300a6a8d6886748f16a3c16d53424f3287abf0c733ab933e37354afc6f77"", ""source_version"": ""Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained"", ""title"": ""Transketolase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P73282.json""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-114_03ee45ca17a3	UniProtKB:P73282	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P73282	ECO:0000256 PIRSR annotation; one thiamine diphosphate per subunit.	"[{""reference_id"": ""UniProtKB:P73282"", ""source_assertion"": ""ECO:0000256 PIRSR annotation; one thiamine diphosphate per subunit."", ""source_locator"": ""/results/12/comments/7""}]"	"[{""id"": ""UniProtKB:P73282"", ""source_sha256"": ""bf02300a6a8d6886748f16a3c16d53424f3287abf0c733ab933e37354afc6f77"", ""source_version"": ""Original current UniProt batch JSON; exact entry selected by primaryAccession; Kazusa taxon and evidence codes retained"", ""title"": ""Transketolase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P73282.json""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-115_44d5f1575a03	CHEBI:456215	pathwaymech:inhibits	MetaCyc:CPLX-162	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:456215|MetaCyc:REG-8538|MetaCyc:REG-8539|PMID:24286336	AMP inhibition of both native activities is a database assertion; charged AMP is a model normalization. Active and AMP-bound inactive tetramers are condition-dependent, not one invariant catalytic state.	"[{""reference_id"": ""MetaCyc:REG-8538"", ""source_assertion"": ""The native regulation has mode -, regulator AMP and FBPase activity ENZRXN-183 of CPLX-162."", ""source_locator"": ""/ptools-xml/Regulation""}, {""reference_id"": ""MetaCyc:REG-8539"", ""source_assertion"": ""The native regulation has mode -, regulator AMP and SBPase activity ENZRXN-182 of CPLX-162."", ""source_locator"": ""/ptools-xml/Regulation""}, {""reference_id"": ""CHEBI:456215"", ""source_assertion"": ""The selected chemical is AMP(2-), the explicitly charged representation used for the native AMP regulator."", ""source_locator"": ""statements subject CHEBI:456215; rdfs:label, chemrof:inchi_string""}, {""reference_id"": ""PMID:24286336"", ""source_assertion"": ""In the recombinant FBP phosphatase assay, AMP has reported IC50 34 ± 2.4 micromolar and stabilizes an inactive tetramer; no SBP-assay IC50 was determined."", ""source_locator"": ""Results: Molecular details of interaction between cy-FBP/SBPase and AMP; Table 2""}]"	"[{""id"": ""CHEBI:456215"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; original complete uncompressed Semantic SQL digest, exact charged identity"", ""title"": ""adenosine 5'-monophosphate(2-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:REG-8538"", ""source_sha256"": ""f21a89b562bd4ebd215006977518463c1bb8b2808bf7ad73119cb98c639c53aa"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""REG-8538"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:REG-8538""}, {""id"": ""MetaCyc:REG-8539"", ""source_sha256"": ""4d4acbdd3ae05833c12a8acdf6b86db24e007b008daf42338fe3f147f817f0b7"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""REG-8539"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:REG-8539""}, {""id"": ""PMID:24286336"", ""source_version"": ""Full original official article inspected through web; local response 403 retained separately. No full-text byte hash or offline article replay is claimed"", ""title"": ""Structural and biochemical characterization of fructose-1,6/sedoheptulose-1,7-bisphosphatase from the cyanobacterium Synechocystis strain 6803"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.12657""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-116_f59977ff3038	CHEBI:18420	pathwaymech:activates	MetaCyc:CPLX-105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:REG-10188	Native allosteric activation annotation; no new concentration-response experiment is inferred.	"[{""reference_id"": ""MetaCyc:REG-10188"", ""source_assertion"": ""The native regulation has mode +, regulator MG+2, mechanism ALLOSTERIC and ENZRXN-122 of CPLX-105."", ""source_locator"": ""/ptools-xml/Regulation""}]"	"[{""id"": ""MetaCyc:REG-10188"", ""source_sha256"": ""02b484ddab4f43c5d830e89959f2f43e9d5c273f75ddd018582e900e52161f85"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""REG-10188"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:REG-10188""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-117_945fef1e6b19	MetaCyc:CPLX-105	RO:0001025	GO:0031470	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-105|PMID:17993516	Native PCC6803 Rubisco is associated with carboxysome interior and shell fractions. This does not place the entire 13-member cycle inside carboxysomes.	"[{""reference_id"": ""PMID:17993516"", ""source_assertion"": ""Freeze-thaw disruption released about 55% of RbcL; immunoblots detected it in soluble and pelletable fractions, supporting interior and shell-associated Rubisco populations."", ""source_locator"": ""//section[@id='sec16']/p[1]""}, {""reference_id"": ""MetaCyc:CPLX-105"", ""source_assertion"": ""The native assembly is scoped to Synechocystis sp. PCC 6803."", ""source_locator"": ""/ptools-xml/Protein/species""}]"	"[{""id"": ""MetaCyc:CPLX-105"", ""source_sha256"": ""d5874c642a990903d28cb9f795a2ebe879334d62513ab13cc82f41f3f6a411eb"", ""source_version"": ""MetaCyc 27.0 original XML from the INSA Lyon mirror; native assertion scope retained"", ""title"": ""ribulose bisphosphate carboxylase/oxygenase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPLX-105""}, {""id"": ""PMID:17993516"", ""source_sha256"": ""6dbacee89d758f79b3b1c10db433c914d0ae3007ff88a6f41083ae0ff5f65b4f"", ""source_version"": ""Original full primary HTML; parent PCC6803 cultures, not a Kazusa-specific preparation"", ""title"": ""A Multiprotein Bicarbonate Dehydration Complex Essential to Carboxysome Function in Cyanobacteria"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2223583/""}]"	""
pathwaymech:MetaCyc_CALVIN-PWY_calvin-edge-118_39a2aacc8c71	UniProtKB:P73654	pathwaymech:regulates	MetaCyc:CALVIN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.3389/fpls.2022.1028794|PMID:36330266|UniProtKB:P73654	Conditional system-level genetic/physiological inference from sequence-matched WT complementation in GT PCC6803. CP12-dependent PRK/GapDH2 foci, metabolite pools and pooled NAD(P)H kinetics do not measure purified inhibition, exact complex stoichiometry, NADPH-specific flux or native Kazusa physiology.	"[{""reference_id"": ""PMID:36330266"", ""source_assertion"": ""WT CP12 restores glucose growth and WT-like NAD(P)H kinetics in delta-cp12 GT PCC6803. CP12-dependent PRK/GapDH2 foci and metabolite phenotypes support conditional CBB regulation; direct enzyme inhibition was not measured."", ""source_locator"": ""//sec[@id=\""s2_1\""]/p[1] | //sec[@id=\""s3_1\""]/p | //sec[@id=\""s3_2\""]/p[position()=2 or position()=4 or position()=5] | //sec[@id=\""s3_4\""]/p""}, {""reference_id"": ""DOI:10.3389/fpls.2022.1028794"", ""source_assertion"": ""The complete synthetic WT coding sequence in Figure S2A translates to 74 residues matching P73654 exactly. Table S1 identifies GT PCC6803 without a specific GT substrain."", ""source_locator"": ""DataSheet_1.pdf printed page 4 Figure S2A; page 2 Table S1""}, {""reference_id"": ""UniProtKB:P73654"", ""source_assertion"": ""The issuing entry supplies the exact 74-residue sequence and Kazusa taxon; its CP12 domain is inferred and does not itself supply the primary regulatory claim."", ""source_locator"": ""/results/0/primaryAccession; /results/0/organism; /results/0/sequence""}]"	"[{""id"": ""DOI:10.3389/fpls.2022.1028794"", ""source_sha256"": ""1cb35b00eae72e8fa0b887c15c67caeaab7e3abc8d44668d5bae49c644dfb6bb"", ""source_version"": ""Original publisher supplementary PDF extracted from the retained Europe PMC ZIP; digest covers the PDF member, not the ZIP"", ""title"": ""CP12 fine-tunes the Calvin-Benson cycle and carbohydrate metabolism in cyanobacteria — supplementary DataSheet_1.pdf"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9623430/supplementaryFiles""}, {""id"": ""PMID:36330266"", ""source_sha256"": ""01de45d96a63c4affc6190ea35574feafdc7ffd221f54c98f719315605e3b93d"", ""source_version"": ""Original full primary JATS; glucose-tolerant PCC6803 with unspecified GT substrain; genetic/physiological scope"", ""title"": ""CP12 fine-tunes the Calvin-Benson cycle and carbohydrate metabolism in cyanobacteria"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC9623430/""}, {""id"": ""UniProtKB:P73654"", ""source_sha256"": ""d98c8885ca4d2bc6b92431b8c15acc7e6cfb52ba79c47345c71df58989043fff"", ""source_version"": ""Original UniProt batch JSON, results[0] P73654; canonical label and full 74-aa Kazusa sequence, not a direct functional annotation"", ""title"": ""Ssl3364 protein"", ""url"": ""https://rest.uniprot.org/uniprotkb/P73654.json""}]"	""
pathwaymech:GO_0043427_threehp-edge-001_2c90f1254ce2	CHEBI:16526	pathwaymech:consumes	RHEA:10750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea directed reaction RHEA:10750 places CHEBI:16526 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10750 rh:substrates http://rdf.rhea-db.org/10748_R; http://rdf.rhea-db.org/10748_R rh:contains1 http://rdf.rhea-db.org/Participant_10748_compound_4391; http://rdf.rhea-db.org/Participant_10748_compound_4391 rh:compound http://rdf.rhea-db.org/Compound_4391; rh:accession""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""CO2 + H2O => hydrogencarbonate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-002_ab8851652fc9	CHEBI:15377	pathwaymech:consumes	RHEA:10750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea directed reaction RHEA:10750 places CHEBI:15377 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10750 rh:substrates http://rdf.rhea-db.org/10748_R; http://rdf.rhea-db.org/10748_R rh:contains1 http://rdf.rhea-db.org/Participant_10748_compound_1283; http://rdf.rhea-db.org/Participant_10748_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; rh:accession""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""CO2 + H2O => hydrogencarbonate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-003_312b00ff5683	RHEA:10750	pathwaymech:produces	CHEBI:17544	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea directed reaction RHEA:10750 places CHEBI:17544 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10750 rh:products http://rdf.rhea-db.org/10748_L; http://rdf.rhea-db.org/10748_L rh:contains1 http://rdf.rhea-db.org/Participant_10748_compound_1123; http://rdf.rhea-db.org/Participant_10748_compound_1123 rh:compound http://rdf.rhea-db.org/Compound_1123; rh:accession""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""CO2 + H2O => hydrogencarbonate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-004_cd3b4674a481	RHEA:10750	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea directed reaction RHEA:10750 places CHEBI:15378 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10750 rh:products http://rdf.rhea-db.org/10748_L; http://rdf.rhea-db.org/10748_L rh:contains1 http://rdf.rhea-db.org/Participant_10748_compound_3249; http://rdf.rhea-db.org/Participant_10748_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""CO2 + H2O => hydrogencarbonate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-005_c7e69decb52b	CHEBI:29806	pathwaymech:consumes	RHEA:12462	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12462	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:12462"", ""source_assertion"": ""Rhea directed reaction RHEA:12462 places CHEBI:29806 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/12462 rh:substrates http://rdf.rhea-db.org/12460_R; http://rdf.rhea-db.org/12460_R rh:contains1 http://rdf.rhea-db.org/Participant_12460_compound_3031; http://rdf.rhea-db.org/Participant_12460_compound_3031 rh:compound http://rdf.rhea-db.org/Compound_3031; rh:accession""}]"	"[{""id"": ""RHEA:12462"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""fumarate + H2O => (S)-malate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-006_f7cae7f38ba4	CHEBI:15377	pathwaymech:consumes	RHEA:12462	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12462	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:12462"", ""source_assertion"": ""Rhea directed reaction RHEA:12462 places CHEBI:15377 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/12462 rh:substrates http://rdf.rhea-db.org/12460_R; http://rdf.rhea-db.org/12460_R rh:contains1 http://rdf.rhea-db.org/Participant_12460_compound_1283; http://rdf.rhea-db.org/Participant_12460_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; rh:accession""}]"	"[{""id"": ""RHEA:12462"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""fumarate + H2O => (S)-malate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-007_fa3be99d1fa8	RHEA:12462	pathwaymech:produces	CHEBI:15589	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12462	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:12462"", ""source_assertion"": ""Rhea directed reaction RHEA:12462 places CHEBI:15589 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/12462 rh:products http://rdf.rhea-db.org/12460_L; http://rdf.rhea-db.org/12460_L rh:contains1 http://rdf.rhea-db.org/Participant_12460_compound_3953; http://rdf.rhea-db.org/Participant_12460_compound_3953 rh:compound http://rdf.rhea-db.org/Compound_3953; rh:accession""}]"	"[{""id"": ""RHEA:12462"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""fumarate + H2O => (S)-malate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-008_f9eb41c358b5	RHEA-COMP:10505	pathwaymech:consumes	RHEA:13502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13502	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea directed reaction RHEA:13502 places RHEA-COMP:10505 on its substrates side with coefficient 1. This is the complete generic protein-bearing carrier state, not its isolated lysine residue."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:substrates http://rdf.rhea-db.org/13501_L; http://rdf.rhea-db.org/13501_L rh:contains1 http://rdf.rhea-db.org/Participant_13501_compound_10505; http://rdf.rhea-db.org/Participant_13501_compound_10505 rh:compound http://rdf.rhea-db.org/Compound_10505; rh:accession""}]"	"[{""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-009_509ec838c321	CHEBI:17544	pathwaymech:consumes	RHEA:13502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13502	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea directed reaction RHEA:13502 places CHEBI:17544 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:substrates http://rdf.rhea-db.org/13501_L; http://rdf.rhea-db.org/13501_L rh:contains1 http://rdf.rhea-db.org/Participant_13501_compound_1123; http://rdf.rhea-db.org/Participant_13501_compound_1123 rh:compound http://rdf.rhea-db.org/Compound_1123; rh:accession""}]"	"[{""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-010_0186732aae80	CHEBI:30616	pathwaymech:consumes	RHEA:13502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13502	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea directed reaction RHEA:13502 places CHEBI:30616 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:substrates http://rdf.rhea-db.org/13501_L; http://rdf.rhea-db.org/13501_L rh:contains1 http://rdf.rhea-db.org/Participant_13501_compound_6372; http://rdf.rhea-db.org/Participant_13501_compound_6372 rh:compound http://rdf.rhea-db.org/Compound_6372; rh:accession""}]"	"[{""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-011_9f88d2eb5082	RHEA:13502	pathwaymech:produces	RHEA-COMP:10506	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13502	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea directed reaction RHEA:13502 places RHEA-COMP:10506 on its products side with coefficient 1. This is the complete generic protein-bearing carrier state, not its isolated lysine residue."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:products http://rdf.rhea-db.org/13501_R; http://rdf.rhea-db.org/13501_R rh:contains1 http://rdf.rhea-db.org/Participant_13501_compound_10506; http://rdf.rhea-db.org/Participant_13501_compound_10506 rh:compound http://rdf.rhea-db.org/Compound_10506; rh:accession""}]"	"[{""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-012_5960b8eb17b0	RHEA:13502	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13502	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea directed reaction RHEA:13502 places CHEBI:456216 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:products http://rdf.rhea-db.org/13501_R; http://rdf.rhea-db.org/13501_R rh:contains1 http://rdf.rhea-db.org/Participant_13501_compound_2710; http://rdf.rhea-db.org/Participant_13501_compound_2710 rh:compound http://rdf.rhea-db.org/Compound_2710; rh:accession""}]"	"[{""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-013_955912ee7690	RHEA:13502	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13502	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea directed reaction RHEA:13502 places CHEBI:43474 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:products http://rdf.rhea-db.org/13501_R; http://rdf.rhea-db.org/13501_R rh:contains1 http://rdf.rhea-db.org/Participant_13501_compound_5518; http://rdf.rhea-db.org/Participant_13501_compound_5518 rh:compound http://rdf.rhea-db.org/Compound_5518; rh:accession""}]"	"[{""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-014_4a7ca3eba4f5	RHEA:13502	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13502	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea directed reaction RHEA:13502 places CHEBI:15378 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:products http://rdf.rhea-db.org/13501_R; http://rdf.rhea-db.org/13501_R rh:contains1 http://rdf.rhea-db.org/Participant_13501_compound_3249; http://rdf.rhea-db.org/Participant_13501_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-015_e30507cae548	CHEBI:57317	pathwaymech:consumes	RHEA:16630	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16630	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:16630"", ""source_assertion"": ""Rhea directed reaction RHEA:16630 places CHEBI:57317 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/16630 rh:substrates http://rdf.rhea-db.org/16629_L; http://rdf.rhea-db.org/16629_L rh:contains1 http://rdf.rhea-db.org/Participant_16629_compound_3610; http://rdf.rhea-db.org/Participant_16629_compound_3610 rh:compound http://rdf.rhea-db.org/Compound_3610; rh:accession""}]"	"[{""id"": ""RHEA:16630"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""(S)-malyl-CoA => glyoxylate + acetyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-016_05127c420357	RHEA:16630	pathwaymech:produces	CHEBI:36655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16630	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:16630"", ""source_assertion"": ""Rhea directed reaction RHEA:16630 places CHEBI:36655 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/16630 rh:products http://rdf.rhea-db.org/16629_R; http://rdf.rhea-db.org/16629_R rh:contains1 http://rdf.rhea-db.org/Participant_16629_compound_3124; http://rdf.rhea-db.org/Participant_16629_compound_3124 rh:compound http://rdf.rhea-db.org/Compound_3124; rh:accession""}]"	"[{""id"": ""RHEA:16630"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""(S)-malyl-CoA => glyoxylate + acetyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-017_a70834ec00d6	RHEA:16630	pathwaymech:produces	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16630	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:16630"", ""source_assertion"": ""Rhea directed reaction RHEA:16630 places CHEBI:57288 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/16630 rh:products http://rdf.rhea-db.org/16629_R; http://rdf.rhea-db.org/16629_R rh:contains1 http://rdf.rhea-db.org/Participant_16629_compound_4271; http://rdf.rhea-db.org/Participant_16629_compound_4271 rh:compound http://rdf.rhea-db.org/Compound_4271; rh:accession""}]"	"[{""id"": ""RHEA:16630"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""(S)-malyl-CoA => glyoxylate + acetyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-018_638cf1c6f895	CHEBI:57327	pathwaymech:consumes	RHEA:20555	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20555	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:20555"", ""source_assertion"": ""Rhea directed reaction RHEA:20555 places CHEBI:57327 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/20555 rh:substrates http://rdf.rhea-db.org/20553_R; http://rdf.rhea-db.org/20553_R rh:contains1 http://rdf.rhea-db.org/Participant_20553_compound_2780; http://rdf.rhea-db.org/Participant_20553_compound_2780 rh:compound http://rdf.rhea-db.org/Compound_2780; rh:accession""}]"	"[{""id"": ""RHEA:20555"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""(S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-019_b04f13c22335	RHEA:20555	pathwaymech:produces	CHEBI:57326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20555	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:20555"", ""source_assertion"": ""Rhea directed reaction RHEA:20555 places CHEBI:57326 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/20555 rh:products http://rdf.rhea-db.org/20553_L; http://rdf.rhea-db.org/20553_L rh:contains1 http://rdf.rhea-db.org/Participant_20553_compound_1391; http://rdf.rhea-db.org/Participant_20553_compound_1391 rh:compound http://rdf.rhea-db.org/Compound_1391; rh:accession""}]"	"[{""id"": ""RHEA:20555"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""(S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-020_d7478fe4b2e6	CHEBI:57326	pathwaymech:consumes	RHEA:22889	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22889	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:22889"", ""source_assertion"": ""Rhea directed reaction RHEA:22889 places CHEBI:57326 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22889 rh:substrates http://rdf.rhea-db.org/22888_L; http://rdf.rhea-db.org/22888_L rh:contains1 http://rdf.rhea-db.org/Participant_22888_compound_1391; http://rdf.rhea-db.org/Participant_22888_compound_1391 rh:compound http://rdf.rhea-db.org/Compound_1391; rh:accession""}]"	"[{""id"": ""RHEA:22889"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""(R)-methylmalonyl-CoA => succinyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-021_6c5d48b6a9bf	RHEA:22889	pathwaymech:produces	CHEBI:57292	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22889	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:22889"", ""source_assertion"": ""Rhea directed reaction RHEA:22889 places CHEBI:57292 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22889 rh:products http://rdf.rhea-db.org/22888_R; http://rdf.rhea-db.org/22888_R rh:contains1 http://rdf.rhea-db.org/Participant_22888_compound_4684; http://rdf.rhea-db.org/Participant_22888_compound_4684 rh:compound http://rdf.rhea-db.org/Compound_4684; rh:accession""}]"	"[{""id"": ""RHEA:22889"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""(R)-methylmalonyl-CoA => succinyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-022_2bfdaee466cb	CHEBI:57392	pathwaymech:consumes	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Rhea directed reaction RHEA:23721 places CHEBI:57392 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23721 rh:substrates http://rdf.rhea-db.org/23720_L; http://rdf.rhea-db.org/23720_L rh:contains1 http://rdf.rhea-db.org/Participant_23720_compound_3421; http://rdf.rhea-db.org/Participant_23720_compound_3421 rh:compound http://rdf.rhea-db.org/Compound_3421; rh:accession""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-023_7a1ecb854c83	CHEBI:17544	pathwaymech:consumes	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Rhea directed reaction RHEA:23721 places CHEBI:17544 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23721 rh:substrates http://rdf.rhea-db.org/23720_L; http://rdf.rhea-db.org/23720_L rh:contains1 http://rdf.rhea-db.org/Participant_23720_compound_1123; http://rdf.rhea-db.org/Participant_23720_compound_1123 rh:compound http://rdf.rhea-db.org/Compound_1123; rh:accession""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-024_516de1830919	CHEBI:30616	pathwaymech:consumes	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Rhea directed reaction RHEA:23721 places CHEBI:30616 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23721 rh:substrates http://rdf.rhea-db.org/23720_L; http://rdf.rhea-db.org/23720_L rh:contains1 http://rdf.rhea-db.org/Participant_23720_compound_6372; http://rdf.rhea-db.org/Participant_23720_compound_6372 rh:compound http://rdf.rhea-db.org/Compound_6372; rh:accession""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-025_c04cc971b837	RHEA:23721	pathwaymech:produces	CHEBI:57327	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Rhea directed reaction RHEA:23721 places CHEBI:57327 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23721 rh:products http://rdf.rhea-db.org/23720_R; http://rdf.rhea-db.org/23720_R rh:contains1 http://rdf.rhea-db.org/Participant_23720_compound_2780; http://rdf.rhea-db.org/Participant_23720_compound_2780 rh:compound http://rdf.rhea-db.org/Compound_2780; rh:accession""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-026_fc7a1df56c70	RHEA:23721	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Rhea directed reaction RHEA:23721 places CHEBI:456216 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23721 rh:products http://rdf.rhea-db.org/23720_R; http://rdf.rhea-db.org/23720_R rh:contains1 http://rdf.rhea-db.org/Participant_23720_compound_2710; http://rdf.rhea-db.org/Participant_23720_compound_2710 rh:compound http://rdf.rhea-db.org/Compound_2710; rh:accession""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-027_a6dfd7916122	RHEA:23721	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Rhea directed reaction RHEA:23721 places CHEBI:43474 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23721 rh:products http://rdf.rhea-db.org/23720_R; http://rdf.rhea-db.org/23720_R rh:contains1 http://rdf.rhea-db.org/Participant_23720_compound_5518; http://rdf.rhea-db.org/Participant_23720_compound_5518 rh:compound http://rdf.rhea-db.org/Compound_5518; rh:accession""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-028_855f09fc747d	RHEA:23721	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Rhea directed reaction RHEA:23721 places CHEBI:15378 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23721 rh:products http://rdf.rhea-db.org/23720_R; http://rdf.rhea-db.org/23720_R rh:contains1 http://rdf.rhea-db.org/Participant_23720_compound_3249; http://rdf.rhea-db.org/Participant_23720_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-029_d331da8bea76	CHEBI:33190	pathwaymech:consumes	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea directed reaction RHEA:26440 places CHEBI:33190 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:substrates http://rdf.rhea-db.org/26438_R; http://rdf.rhea-db.org/26438_R rh:contains1 http://rdf.rhea-db.org/Participant_26438_compound_5274; http://rdf.rhea-db.org/Participant_26438_compound_5274 rh:compound http://rdf.rhea-db.org/Compound_5274; rh:accession""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-030_1f480bd6145f	CHEBI:57783	pathwaymech:consumes	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea directed reaction RHEA:26440 places CHEBI:57783 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:substrates http://rdf.rhea-db.org/26438_R; http://rdf.rhea-db.org/26438_R rh:contains1 http://rdf.rhea-db.org/Participant_26438_compound_3438; http://rdf.rhea-db.org/Participant_26438_compound_3438 rh:compound http://rdf.rhea-db.org/Compound_3438; rh:accession""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-031_e4e519bb78fa	CHEBI:15378	pathwaymech:consumes	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea directed reaction RHEA:26440 places CHEBI:15378 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:substrates http://rdf.rhea-db.org/26438_R; http://rdf.rhea-db.org/26438_R rh:contains1 http://rdf.rhea-db.org/Participant_26438_compound_3249; http://rdf.rhea-db.org/Participant_26438_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-032_c333b101ddfd	RHEA:26440	pathwaymech:produces	CHEBI:16510	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea directed reaction RHEA:26440 places CHEBI:16510 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:products http://rdf.rhea-db.org/26438_L; http://rdf.rhea-db.org/26438_L rh:contains1 http://rdf.rhea-db.org/Participant_26438_compound_3378; http://rdf.rhea-db.org/Participant_26438_compound_3378 rh:compound http://rdf.rhea-db.org/Compound_3378; rh:accession""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-033_505fd81c4870	RHEA:26440	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea directed reaction RHEA:26440 places CHEBI:58349 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:products http://rdf.rhea-db.org/26438_L; http://rdf.rhea-db.org/26438_L rh:contains1 http://rdf.rhea-db.org/Participant_26438_compound_5188; http://rdf.rhea-db.org/Participant_26438_compound_5188 rh:compound http://rdf.rhea-db.org/Compound_5188; rh:accession""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-034_97df39a223bb	CHEBI:57384	pathwaymech:consumes	RHEA:26448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea directed reaction RHEA:26448 places CHEBI:57384 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448 rh:substrates http://rdf.rhea-db.org/26446_R; http://rdf.rhea-db.org/26446_R rh:contains1 http://rdf.rhea-db.org/Participant_26446_compound_5125; http://rdf.rhea-db.org/Participant_26446_compound_5125 rh:compound http://rdf.rhea-db.org/Compound_5125; rh:accession""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""malonyl-CoA + NADPH + H(+) => 3-oxopropanoate + NADP(+) + CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-035_a2cc22dab81d	CHEBI:57783	pathwaymech:consumes	RHEA:26448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea directed reaction RHEA:26448 places CHEBI:57783 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448 rh:substrates http://rdf.rhea-db.org/26446_R; http://rdf.rhea-db.org/26446_R rh:contains1 http://rdf.rhea-db.org/Participant_26446_compound_3438; http://rdf.rhea-db.org/Participant_26446_compound_3438 rh:compound http://rdf.rhea-db.org/Compound_3438; rh:accession""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""malonyl-CoA + NADPH + H(+) => 3-oxopropanoate + NADP(+) + CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-036_2a6697927b39	CHEBI:15378	pathwaymech:consumes	RHEA:26448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea directed reaction RHEA:26448 places CHEBI:15378 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448 rh:substrates http://rdf.rhea-db.org/26446_R; http://rdf.rhea-db.org/26446_R rh:contains1 http://rdf.rhea-db.org/Participant_26446_compound_3249; http://rdf.rhea-db.org/Participant_26446_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""malonyl-CoA + NADPH + H(+) => 3-oxopropanoate + NADP(+) + CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-037_5c40cedc5764	RHEA:26448	pathwaymech:produces	CHEBI:33190	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea directed reaction RHEA:26448 places CHEBI:33190 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448 rh:products http://rdf.rhea-db.org/26446_L; http://rdf.rhea-db.org/26446_L rh:contains1 http://rdf.rhea-db.org/Participant_26446_compound_5274; http://rdf.rhea-db.org/Participant_26446_compound_5274 rh:compound http://rdf.rhea-db.org/Compound_5274; rh:accession""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""malonyl-CoA + NADPH + H(+) => 3-oxopropanoate + NADP(+) + CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-038_1a44a80a5f45	RHEA:26448	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea directed reaction RHEA:26448 places CHEBI:58349 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448 rh:products http://rdf.rhea-db.org/26446_L; http://rdf.rhea-db.org/26446_L rh:contains1 http://rdf.rhea-db.org/Participant_26446_compound_5188; http://rdf.rhea-db.org/Participant_26446_compound_5188 rh:compound http://rdf.rhea-db.org/Compound_5188; rh:accession""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""malonyl-CoA + NADPH + H(+) => 3-oxopropanoate + NADP(+) + CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-039_9e3accf63aff	RHEA:26448	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea directed reaction RHEA:26448 places CHEBI:57287 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448 rh:products http://rdf.rhea-db.org/26446_L; http://rdf.rhea-db.org/26446_L rh:contains1 http://rdf.rhea-db.org/Participant_26446_compound_1264; http://rdf.rhea-db.org/Participant_26446_compound_1264 rh:compound http://rdf.rhea-db.org/Compound_1264; rh:accession""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""malonyl-CoA + NADPH + H(+) => 3-oxopropanoate + NADP(+) + CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-040_5bbe69a6c066	CHEBI:57367	pathwaymech:consumes	RHEA:26456	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea directed reaction RHEA:26456 places CHEBI:57367 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456 rh:substrates http://rdf.rhea-db.org/26454_R; http://rdf.rhea-db.org/26454_R rh:contains1 http://rdf.rhea-db.org/Participant_26454_compound_2006; http://rdf.rhea-db.org/Participant_26454_compound_2006 rh:compound http://rdf.rhea-db.org/Compound_2006; rh:accession""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""acryloyl-CoA + NADPH + H(+) => propanoyl-CoA + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-041_c49c52d0b35e	CHEBI:57783	pathwaymech:consumes	RHEA:26456	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea directed reaction RHEA:26456 places CHEBI:57783 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456 rh:substrates http://rdf.rhea-db.org/26454_R; http://rdf.rhea-db.org/26454_R rh:contains1 http://rdf.rhea-db.org/Participant_26454_compound_3438; http://rdf.rhea-db.org/Participant_26454_compound_3438 rh:compound http://rdf.rhea-db.org/Compound_3438; rh:accession""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""acryloyl-CoA + NADPH + H(+) => propanoyl-CoA + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-042_7e7da55c3ecc	CHEBI:15378	pathwaymech:consumes	RHEA:26456	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea directed reaction RHEA:26456 places CHEBI:15378 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456 rh:substrates http://rdf.rhea-db.org/26454_R; http://rdf.rhea-db.org/26454_R rh:contains1 http://rdf.rhea-db.org/Participant_26454_compound_3249; http://rdf.rhea-db.org/Participant_26454_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""acryloyl-CoA + NADPH + H(+) => propanoyl-CoA + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-043_ccd13f6cd317	RHEA:26456	pathwaymech:produces	CHEBI:57392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea directed reaction RHEA:26456 places CHEBI:57392 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456 rh:products http://rdf.rhea-db.org/26454_L; http://rdf.rhea-db.org/26454_L rh:contains1 http://rdf.rhea-db.org/Participant_26454_compound_3421; http://rdf.rhea-db.org/Participant_26454_compound_3421 rh:compound http://rdf.rhea-db.org/Compound_3421; rh:accession""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""acryloyl-CoA + NADPH + H(+) => propanoyl-CoA + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-044_12a33b704938	RHEA:26456	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea directed reaction RHEA:26456 places CHEBI:58349 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456 rh:products http://rdf.rhea-db.org/26454_L; http://rdf.rhea-db.org/26454_L rh:contains1 http://rdf.rhea-db.org/Participant_26454_compound_5188; http://rdf.rhea-db.org/Participant_26454_compound_5188 rh:compound http://rdf.rhea-db.org/Compound_5188; rh:accession""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""acryloyl-CoA + NADPH + H(+) => propanoyl-CoA + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-045_81fbbbffdc62	CHEBI:58528	pathwaymech:consumes	RHEA:26519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26519	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26519"", ""source_assertion"": ""Rhea directed reaction RHEA:26519 places CHEBI:58528 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26519 rh:substrates http://rdf.rhea-db.org/26518_L; http://rdf.rhea-db.org/26518_L rh:contains1 http://rdf.rhea-db.org/Participant_26518_compound_6030; http://rdf.rhea-db.org/Participant_26518_compound_6030 rh:compound http://rdf.rhea-db.org/Compound_6030; rh:accession""}]"	"[{""id"": ""RHEA:26519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-hydroxypropanoyl-CoA => acryloyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-046_53f74aa26735	RHEA:26519	pathwaymech:produces	CHEBI:57367	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26519	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26519"", ""source_assertion"": ""Rhea directed reaction RHEA:26519 places CHEBI:57367 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26519 rh:products http://rdf.rhea-db.org/26518_R; http://rdf.rhea-db.org/26518_R rh:contains1 http://rdf.rhea-db.org/Participant_26518_compound_2006; http://rdf.rhea-db.org/Participant_26518_compound_2006 rh:compound http://rdf.rhea-db.org/Compound_2006; rh:accession""}]"	"[{""id"": ""RHEA:26519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-hydroxypropanoyl-CoA => acryloyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-047_d7022a7ad5ba	RHEA:26519	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26519	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26519"", ""source_assertion"": ""Rhea directed reaction RHEA:26519 places CHEBI:15377 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26519 rh:products http://rdf.rhea-db.org/26518_R; http://rdf.rhea-db.org/26518_R rh:contains1 http://rdf.rhea-db.org/Participant_26518_compound_1283; http://rdf.rhea-db.org/Participant_26518_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; rh:accession""}]"	"[{""id"": ""RHEA:26519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-hydroxypropanoyl-CoA => acryloyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-048_d90974139cfd	CHEBI:16510	pathwaymech:consumes	RHEA:26535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26535	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea directed reaction RHEA:26535 places CHEBI:16510 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535 rh:substrates http://rdf.rhea-db.org/26534_L; http://rdf.rhea-db.org/26534_L rh:contains1 http://rdf.rhea-db.org/Participant_26534_compound_3378; http://rdf.rhea-db.org/Participant_26534_compound_3378 rh:compound http://rdf.rhea-db.org/Compound_3378; rh:accession""}]"	"[{""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-049_d176ab6ea8b3	CHEBI:30616	pathwaymech:consumes	RHEA:26535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26535	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea directed reaction RHEA:26535 places CHEBI:30616 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535 rh:substrates http://rdf.rhea-db.org/26534_L; http://rdf.rhea-db.org/26534_L rh:contains1 http://rdf.rhea-db.org/Participant_26534_compound_6372; http://rdf.rhea-db.org/Participant_26534_compound_6372 rh:compound http://rdf.rhea-db.org/Compound_6372; rh:accession""}]"	"[{""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-050_f7da5390c70d	CHEBI:57287	pathwaymech:consumes	RHEA:26535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26535	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea directed reaction RHEA:26535 places CHEBI:57287 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535 rh:substrates http://rdf.rhea-db.org/26534_L; http://rdf.rhea-db.org/26534_L rh:contains1 http://rdf.rhea-db.org/Participant_26534_compound_1264; http://rdf.rhea-db.org/Participant_26534_compound_1264 rh:compound http://rdf.rhea-db.org/Compound_1264; rh:accession""}]"	"[{""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-051_bbeccf6baeac	RHEA:26535	pathwaymech:produces	CHEBI:58528	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26535	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea directed reaction RHEA:26535 places CHEBI:58528 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535 rh:products http://rdf.rhea-db.org/26534_R; http://rdf.rhea-db.org/26534_R rh:contains1 http://rdf.rhea-db.org/Participant_26534_compound_6030; http://rdf.rhea-db.org/Participant_26534_compound_6030 rh:compound http://rdf.rhea-db.org/Compound_6030; rh:accession""}]"	"[{""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-052_2e746fe46249	RHEA:26535	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26535	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea directed reaction RHEA:26535 places CHEBI:456215 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535 rh:products http://rdf.rhea-db.org/26534_R; http://rdf.rhea-db.org/26534_R rh:contains1 http://rdf.rhea-db.org/Participant_26534_compound_2590; http://rdf.rhea-db.org/Participant_26534_compound_2590 rh:compound http://rdf.rhea-db.org/Compound_2590; rh:accession""}]"	"[{""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-053_30af39c9f260	RHEA:26535	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26535	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea directed reaction RHEA:26535 places CHEBI:33019 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535 rh:products http://rdf.rhea-db.org/26534_R; http://rdf.rhea-db.org/26534_R rh:contains1 http://rdf.rhea-db.org/Participant_26534_compound_2106; http://rdf.rhea-db.org/Participant_26534_compound_2106 rh:compound http://rdf.rhea-db.org/Compound_2106; rh:accession""}]"	"[{""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-054_6a9bdee0171f	CHEBI:57292	pathwaymech:consumes	RHEA:38256	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38256	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38256"", ""source_assertion"": ""Rhea directed reaction RHEA:38256 places CHEBI:57292 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38256 rh:substrates http://rdf.rhea-db.org/38255_L; http://rdf.rhea-db.org/38255_L rh:contains1 http://rdf.rhea-db.org/Participant_38255_compound_4684; http://rdf.rhea-db.org/Participant_38255_compound_4684 rh:compound http://rdf.rhea-db.org/Compound_4684; rh:accession""}]"	"[{""id"": ""RHEA:38256"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""succinyl-CoA + (S)-malate => (S)-malyl-CoA + succinate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-055_0d120a6d1e03	CHEBI:15589	pathwaymech:consumes	RHEA:38256	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38256	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38256"", ""source_assertion"": ""Rhea directed reaction RHEA:38256 places CHEBI:15589 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38256 rh:substrates http://rdf.rhea-db.org/38255_L; http://rdf.rhea-db.org/38255_L rh:contains1 http://rdf.rhea-db.org/Participant_38255_compound_3953; http://rdf.rhea-db.org/Participant_38255_compound_3953 rh:compound http://rdf.rhea-db.org/Compound_3953; rh:accession""}]"	"[{""id"": ""RHEA:38256"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""succinyl-CoA + (S)-malate => (S)-malyl-CoA + succinate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-056_ce3abca55ec7	RHEA:38256	pathwaymech:produces	CHEBI:57317	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38256	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38256"", ""source_assertion"": ""Rhea directed reaction RHEA:38256 places CHEBI:57317 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38256 rh:products http://rdf.rhea-db.org/38255_R; http://rdf.rhea-db.org/38255_R rh:contains1 http://rdf.rhea-db.org/Participant_38255_compound_3610; http://rdf.rhea-db.org/Participant_38255_compound_3610 rh:compound http://rdf.rhea-db.org/Compound_3610; rh:accession""}]"	"[{""id"": ""RHEA:38256"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""succinyl-CoA + (S)-malate => (S)-malyl-CoA + succinate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-057_9e5943359159	RHEA:38256	pathwaymech:produces	CHEBI:30031	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38256	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38256"", ""source_assertion"": ""Rhea directed reaction RHEA:38256 places CHEBI:30031 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38256 rh:products http://rdf.rhea-db.org/38255_R; http://rdf.rhea-db.org/38255_R rh:contains1 http://rdf.rhea-db.org/Participant_38255_compound_2501; http://rdf.rhea-db.org/Participant_38255_compound_2501 rh:compound http://rdf.rhea-db.org/Compound_2501; rh:accession""}]"	"[{""id"": ""RHEA:38256"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""succinyl-CoA + (S)-malate => (S)-malyl-CoA + succinate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-058_71826d4beea4	CHEBI:132124	pathwaymech:consumes	RHEA:40524	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40524	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:40524"", ""source_assertion"": ""Rhea directed reaction RHEA:40524 places CHEBI:132124 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/40524 rh:substrates http://rdf.rhea-db.org/40523_L; http://rdf.rhea-db.org/40523_L rh:contains1 http://rdf.rhea-db.org/Participant_40523_compound_13027; http://rdf.rhea-db.org/Participant_40523_compound_13027 rh:compound http://rdf.rhea-db.org/Compound_13027; rh:accession""}]"	"[{""id"": ""RHEA:40524"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""a quinone + succinate => fumarate + a quinol"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-059_8b7b1589905e	CHEBI:30031	pathwaymech:consumes	RHEA:40524	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40524	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:40524"", ""source_assertion"": ""Rhea directed reaction RHEA:40524 places CHEBI:30031 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/40524 rh:substrates http://rdf.rhea-db.org/40523_L; http://rdf.rhea-db.org/40523_L rh:contains1 http://rdf.rhea-db.org/Participant_40523_compound_2501; http://rdf.rhea-db.org/Participant_40523_compound_2501 rh:compound http://rdf.rhea-db.org/Compound_2501; rh:accession""}]"	"[{""id"": ""RHEA:40524"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""a quinone + succinate => fumarate + a quinol"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-060_133169c6f046	RHEA:40524	pathwaymech:produces	CHEBI:29806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40524	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:40524"", ""source_assertion"": ""Rhea directed reaction RHEA:40524 places CHEBI:29806 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/40524 rh:products http://rdf.rhea-db.org/40523_R; http://rdf.rhea-db.org/40523_R rh:contains1 http://rdf.rhea-db.org/Participant_40523_compound_3031; http://rdf.rhea-db.org/Participant_40523_compound_3031 rh:compound http://rdf.rhea-db.org/Compound_3031; rh:accession""}]"	"[{""id"": ""RHEA:40524"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""a quinone + succinate => fumarate + a quinol"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-061_b77e8915934f	RHEA:40524	pathwaymech:produces	CHEBI:24646	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40524	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:40524"", ""source_assertion"": ""Rhea directed reaction RHEA:40524 places CHEBI:24646 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/40524 rh:products http://rdf.rhea-db.org/40523_R; http://rdf.rhea-db.org/40523_R rh:contains1 http://rdf.rhea-db.org/Participant_40523_compound_13026; http://rdf.rhea-db.org/Participant_40523_compound_13026 rh:compound http://rdf.rhea-db.org/Compound_13026; rh:accession""}]"	"[{""id"": ""RHEA:40524"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""a quinone + succinate => fumarate + a quinol"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-062_86b8af9f3b2b	RHEA-COMP:10506	pathwaymech:consumes	RHEA:54729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:54729	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:54729"", ""source_assertion"": ""Rhea directed reaction RHEA:54729 places RHEA-COMP:10506 on its substrates side with coefficient 1. This is the complete generic protein-bearing carrier state, not its isolated lysine residue."", ""source_locator"": ""http://rdf.rhea-db.org/54729 rh:substrates http://rdf.rhea-db.org/54728_L; http://rdf.rhea-db.org/54728_L rh:contains1 http://rdf.rhea-db.org/Participant_54728_compound_10506; http://rdf.rhea-db.org/Participant_54728_compound_10506 rh:compound http://rdf.rhea-db.org/Compound_10506; rh:accession""}]"	"[{""id"": ""RHEA:54729"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA => N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-063_8a2ad0a40ee6	CHEBI:57288	pathwaymech:consumes	RHEA:54729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:54729	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:54729"", ""source_assertion"": ""Rhea directed reaction RHEA:54729 places CHEBI:57288 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/54729 rh:substrates http://rdf.rhea-db.org/54728_L; http://rdf.rhea-db.org/54728_L rh:contains1 http://rdf.rhea-db.org/Participant_54728_compound_4271; http://rdf.rhea-db.org/Participant_54728_compound_4271 rh:compound http://rdf.rhea-db.org/Compound_4271; rh:accession""}]"	"[{""id"": ""RHEA:54729"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA => N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-064_cc297f686eb4	RHEA:54729	pathwaymech:produces	RHEA-COMP:10505	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:54729	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:54729"", ""source_assertion"": ""Rhea directed reaction RHEA:54729 places RHEA-COMP:10505 on its products side with coefficient 1. This is the complete generic protein-bearing carrier state, not its isolated lysine residue."", ""source_locator"": ""http://rdf.rhea-db.org/54729 rh:products http://rdf.rhea-db.org/54728_R; http://rdf.rhea-db.org/54728_R rh:contains1 http://rdf.rhea-db.org/Participant_54728_compound_10505; http://rdf.rhea-db.org/Participant_54728_compound_10505 rh:compound http://rdf.rhea-db.org/Compound_10505; rh:accession""}]"	"[{""id"": ""RHEA:54729"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA => N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-065_53a71c8512dc	RHEA:54729	pathwaymech:produces	CHEBI:57384	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:54729	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:54729"", ""source_assertion"": ""Rhea directed reaction RHEA:54729 places CHEBI:57384 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/54729 rh:products http://rdf.rhea-db.org/54728_R; http://rdf.rhea-db.org/54728_R rh:contains1 http://rdf.rhea-db.org/Participant_54728_compound_5125; http://rdf.rhea-db.org/Participant_54728_compound_5125 rh:compound http://rdf.rhea-db.org/Compound_5125; rh:accession""}]"	"[{""id"": ""RHEA:54729"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA => N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-066_b2ea7a3a52a5	GO:0043427	BFO:0000051	RHEA:10750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5743|MetaCyc:RXN0-5224|RHEA:10750	Native inorganic-carbon equilibration is retained without assigning an unverified carbonic anhydrase; its turnover can supply bicarbonate to either carboxylation step.	"[{""reference_id"": ""MetaCyc:PWY-5743"", ""source_assertion"": ""PWY-5743 explicitly lists RXN0-5224 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-5743']/reaction-list/Reaction[@frameid='RXN0-5224']""}, {""reference_id"": ""MetaCyc:RXN0-5224"", ""source_assertion"": ""The native reaction links Rhea 10751; this supplies the reaction-family bridge, not an independent proof of physiological direction."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea master 10748 explicitly links directed member 10750; its current substrate and product sides define the selected equation."", ""source_locator"": ""http://rdf.rhea-db.org/10748 rh:directionalReaction http://rdf.rhea-db.org/10750; http://rdf.rhea-db.org/10750 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5743"", ""source_sha256"": ""f32080596a30c23f3f9dcda28b4fa56af636d1a1b60828e6a07e75cc68142729"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""3-hydroxypropanoate cycle"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5743""}, {""id"": ""MetaCyc:RXN0-5224"", ""source_sha256"": ""0f8ea48758c659d86a3f3fb429d73ee60560ab80646e4233481caa7e4cf3ffb5"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""RXN0-5224"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5224""}, {""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""CO2 + H2O => hydrogencarbonate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-067_457e8f1489bd	GO:0043427	BFO:0000051	RHEA:13502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-CARBOXYL-RXN|MetaCyc:PWY-5743|RHEA:13502	Complete first-cycle chemistry; current Rhea equation and source-specific native mapping are independently grounded.	"[{""reference_id"": ""MetaCyc:PWY-5743"", ""source_assertion"": ""PWY-5743 explicitly lists BIOTIN-CARBOXYL-RXN as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-5743']/reaction-list/Reaction[@frameid='BIOTIN-CARBOXYL-RXN']""}, {""reference_id"": ""MetaCyc:BIOTIN-CARBOXYL-RXN"", ""source_assertion"": ""The native reaction links Rhea 13502; this supplies the reaction-family bridge, not an independent proof of physiological direction."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea master 13501 explicitly links directed member 13502; its current substrate and product sides define the selected equation."", ""source_locator"": ""http://rdf.rhea-db.org/13501 rh:directionalReaction http://rdf.rhea-db.org/13502; http://rdf.rhea-db.org/13502 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:BIOTIN-CARBOXYL-RXN"", ""source_sha256"": ""85d21badd44d87a38c810e80b4ee276f91cf66fbe2d1995103ffdbb77ec3728b"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""BIOTIN-CARBOXYL-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-CARBOXYL-RXN""}, {""id"": ""MetaCyc:PWY-5743"", ""source_sha256"": ""f32080596a30c23f3f9dcda28b4fa56af636d1a1b60828e6a07e75cc68142729"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""3-hydroxypropanoate cycle"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5743""}, {""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-068_91c38b4dc376	GO:0043427	BFO:0000051	RHEA:54729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5743|MetaCyc:RXN0-5055|RHEA:54729	Complete first-cycle chemistry; current Rhea equation and source-specific native mapping are independently grounded.	"[{""reference_id"": ""MetaCyc:PWY-5743"", ""source_assertion"": ""PWY-5743 explicitly lists RXN0-5055 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-5743']/reaction-list/Reaction[@frameid='RXN0-5055']""}, {""reference_id"": ""MetaCyc:RXN0-5055"", ""source_assertion"": ""The native carboxyl-transfer reaction transfers the carboxyl group from carboxybiotin to acetyl-CoA; the current equation retains whole protein-bound biotin states."", ""source_locator"": ""Reaction[@detail='full']/left; right""}, {""reference_id"": ""RHEA:54729"", ""source_assertion"": ""Rhea master 54728 explicitly links directed member 54729; its current substrate and product sides define the selected equation."", ""source_locator"": ""http://rdf.rhea-db.org/54728 rh:directionalReaction http://rdf.rhea-db.org/54729; http://rdf.rhea-db.org/54729 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5743"", ""source_sha256"": ""f32080596a30c23f3f9dcda28b4fa56af636d1a1b60828e6a07e75cc68142729"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""3-hydroxypropanoate cycle"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5743""}, {""id"": ""MetaCyc:RXN0-5055"", ""source_sha256"": ""7962754112f02260c380c8ee7e5807bf4333ec5c2325852071e114c4884176ed"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""RXN0-5055"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5055""}, {""id"": ""RHEA:54729"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA => N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-069_2692f1955bba	GO:0043427	BFO:0000051	RHEA:26448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5743|MetaCyc:RXN-8963|RHEA:26448	Complete first-cycle chemistry; current Rhea equation and source-specific native mapping are independently grounded.	"[{""reference_id"": ""MetaCyc:PWY-5743"", ""source_assertion"": ""PWY-5743 explicitly lists RXN-8963 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-5743']/reaction-list/Reaction[@frameid='RXN-8963']""}, {""reference_id"": ""MetaCyc:RXN-8963"", ""source_assertion"": ""The native reaction links Rhea 26449; this supplies the reaction-family bridge, not an independent proof of physiological direction."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea master 26446 explicitly links directed member 26448; its current substrate and product sides define the selected equation."", ""source_locator"": ""http://rdf.rhea-db.org/26446 rh:directionalReaction http://rdf.rhea-db.org/26448; http://rdf.rhea-db.org/26448 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5743"", ""source_sha256"": ""f32080596a30c23f3f9dcda28b4fa56af636d1a1b60828e6a07e75cc68142729"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""3-hydroxypropanoate cycle"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5743""}, {""id"": ""MetaCyc:RXN-8963"", ""source_sha256"": ""f0e6b1ac76f3081d1701c4504a9b47a32dd6b325539447e0148ffc48cacaa154"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""RXN-8963"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8963""}, {""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""malonyl-CoA + NADPH + H(+) => 3-oxopropanoate + NADP(+) + CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-070_49043ccf5bdd	GO:0043427	BFO:0000051	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5743|MetaCyc:RXN-8974|RHEA:26440	Complete first-cycle chemistry; current Rhea equation and source-specific native mapping are independently grounded.	"[{""reference_id"": ""MetaCyc:PWY-5743"", ""source_assertion"": ""PWY-5743 explicitly lists RXN-8974 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-5743']/reaction-list/Reaction[@frameid='RXN-8974']""}, {""reference_id"": ""MetaCyc:RXN-8974"", ""source_assertion"": ""The native reaction links Rhea 26440; this supplies the reaction-family bridge, not an independent proof of physiological direction."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea master 26438 explicitly links directed member 26440; its current substrate and product sides define the selected equation."", ""source_locator"": ""http://rdf.rhea-db.org/26438 rh:directionalReaction http://rdf.rhea-db.org/26440; http://rdf.rhea-db.org/26440 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5743"", ""source_sha256"": ""f32080596a30c23f3f9dcda28b4fa56af636d1a1b60828e6a07e75cc68142729"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""3-hydroxypropanoate cycle"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5743""}, {""id"": ""MetaCyc:RXN-8974"", ""source_sha256"": ""ddb5c15214b2047cc5aeae0076f7fc8783861858b628c566363887a83208a824"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""RXN-8974"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8974""}, {""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-071_67f982725969	GO:0043427	BFO:0000051	RHEA:26535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5743|MetaCyc:RXN-9086|RHEA:26535	Complete first-cycle chemistry; current Rhea equation and source-specific native mapping are independently grounded.	"[{""reference_id"": ""MetaCyc:PWY-5743"", ""source_assertion"": ""PWY-5743 explicitly lists RXN-9086 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-5743']/reaction-list/Reaction[@frameid='RXN-9086']""}, {""reference_id"": ""MetaCyc:RXN-9086"", ""source_assertion"": ""The native reaction links Rhea 26535; this supplies the reaction-family bridge, not an independent proof of physiological direction."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea master 26534 explicitly links directed member 26535; its current substrate and product sides define the selected equation."", ""source_locator"": ""http://rdf.rhea-db.org/26534 rh:directionalReaction http://rdf.rhea-db.org/26535; http://rdf.rhea-db.org/26535 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5743"", ""source_sha256"": ""f32080596a30c23f3f9dcda28b4fa56af636d1a1b60828e6a07e75cc68142729"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""3-hydroxypropanoate cycle"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5743""}, {""id"": ""MetaCyc:RXN-9086"", ""source_sha256"": ""b5cfb7a4cae84f5203e562f4a58aa6fc02b3af5532953d0d7249745499f2c791"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""RXN-9086"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9086""}, {""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-072_f110997f956f	GO:0043427	BFO:0000051	RHEA:26519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5743|MetaCyc:RXN-6383|RHEA:26519	Complete first-cycle chemistry; current Rhea equation and source-specific native mapping are independently grounded.	"[{""reference_id"": ""MetaCyc:PWY-5743"", ""source_assertion"": ""PWY-5743 explicitly lists RXN-6383 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-5743']/reaction-list/Reaction[@frameid='RXN-6383']""}, {""reference_id"": ""MetaCyc:RXN-6383"", ""source_assertion"": ""The native reaction links Rhea 26518; this supplies the reaction-family bridge, not an independent proof of physiological direction."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:26519"", ""source_assertion"": ""Rhea master 26518 explicitly links directed member 26519; its current substrate and product sides define the selected equation."", ""source_locator"": ""http://rdf.rhea-db.org/26518 rh:directionalReaction http://rdf.rhea-db.org/26519; http://rdf.rhea-db.org/26519 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5743"", ""source_sha256"": ""f32080596a30c23f3f9dcda28b4fa56af636d1a1b60828e6a07e75cc68142729"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""3-hydroxypropanoate cycle"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5743""}, {""id"": ""MetaCyc:RXN-6383"", ""source_sha256"": ""ca3f42be810f2d950159b350849efcc45a3d5299c860b1e7398b13370878f5fe"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""RXN-6383"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-6383""}, {""id"": ""RHEA:26519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-hydroxypropanoyl-CoA => acryloyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-073_af71de149026	GO:0043427	BFO:0000051	RHEA:26456	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5743|MetaCyc:RXN-9087|RHEA:26456	Complete first-cycle chemistry; current Rhea equation and source-specific native mapping are independently grounded.	"[{""reference_id"": ""MetaCyc:PWY-5743"", ""source_assertion"": ""PWY-5743 explicitly lists RXN-9087 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-5743']/reaction-list/Reaction[@frameid='RXN-9087']""}, {""reference_id"": ""MetaCyc:RXN-9087"", ""source_assertion"": ""The native reaction links Rhea 26456; this supplies the reaction-family bridge, not an independent proof of physiological direction."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea master 26454 explicitly links directed member 26456; its current substrate and product sides define the selected equation."", ""source_locator"": ""http://rdf.rhea-db.org/26454 rh:directionalReaction http://rdf.rhea-db.org/26456; http://rdf.rhea-db.org/26456 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5743"", ""source_sha256"": ""f32080596a30c23f3f9dcda28b4fa56af636d1a1b60828e6a07e75cc68142729"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""3-hydroxypropanoate cycle"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5743""}, {""id"": ""MetaCyc:RXN-9087"", ""source_sha256"": ""1f715ecd994c074e00fe02f4fbbbc58cea6f090ef85eb54516687984683f3b70"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""RXN-9087"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9087""}, {""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""acryloyl-CoA + NADPH + H(+) => propanoyl-CoA + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-074_bc96c9c910e5	GO:0043427	BFO:0000051	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PROPIONYL-COA-CARBOXY-RXN|MetaCyc:PWY-5743|RHEA:23721	Complete first-cycle chemistry; current Rhea equation and source-specific native mapping are independently grounded. Exact Chloroflexus catalytic protein attribution remains unresolved; no archaeal catalyst is substituted.	"[{""reference_id"": ""MetaCyc:PWY-5743"", ""source_assertion"": ""PWY-5743 explicitly lists PROPIONYL-COA-CARBOXY-RXN as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-5743']/reaction-list/Reaction[@frameid='PROPIONYL-COA-CARBOXY-RXN']""}, {""reference_id"": ""MetaCyc:PROPIONYL-COA-CARBOXY-RXN"", ""source_assertion"": ""The native reaction links Rhea 23723; this supplies the reaction-family bridge, not an independent proof of physiological direction."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Rhea master 23720 explicitly links directed member 23721; its current substrate and product sides define the selected equation."", ""source_locator"": ""http://rdf.rhea-db.org/23720 rh:directionalReaction http://rdf.rhea-db.org/23721; http://rdf.rhea-db.org/23721 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PROPIONYL-COA-CARBOXY-RXN"", ""source_sha256"": ""7fde942e7cd22e87b0f3ab23c2db314b37fa1c4252e0afabef930edba7db7ab6"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""PROPIONYL-COA-CARBOXY-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROPIONYL-COA-CARBOXY-RXN""}, {""id"": ""MetaCyc:PWY-5743"", ""source_sha256"": ""f32080596a30c23f3f9dcda28b4fa56af636d1a1b60828e6a07e75cc68142729"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""3-hydroxypropanoate cycle"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5743""}, {""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-075_f518116f097b	GO:0043427	BFO:0000051	RHEA:20555	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:METHYLMALONYL-COA-EPIM-RXN|MetaCyc:PWY-5743|RHEA:20555	Complete first-cycle chemistry; current Rhea equation and source-specific native mapping are independently grounded. Exact Chloroflexus catalytic protein attribution remains unresolved; no archaeal catalyst is substituted.	"[{""reference_id"": ""MetaCyc:PWY-5743"", ""source_assertion"": ""PWY-5743 explicitly lists METHYLMALONYL-COA-EPIM-RXN as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-5743']/reaction-list/Reaction[@frameid='METHYLMALONYL-COA-EPIM-RXN']""}, {""reference_id"": ""MetaCyc:METHYLMALONYL-COA-EPIM-RXN"", ""source_assertion"": ""The native reaction links Rhea 20556; this supplies the reaction-family bridge, not an independent proof of physiological direction."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:20555"", ""source_assertion"": ""Rhea master 20553 explicitly links directed member 20555; its current substrate and product sides define the selected equation."", ""source_locator"": ""http://rdf.rhea-db.org/20553 rh:directionalReaction http://rdf.rhea-db.org/20555; http://rdf.rhea-db.org/20555 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:METHYLMALONYL-COA-EPIM-RXN"", ""source_sha256"": ""494f1041d42ff4b61cad3b36a1abbc26021ccb8e9f845fe3f5abb4bb18cad63b"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""METHYLMALONYL-COA-EPIM-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:METHYLMALONYL-COA-EPIM-RXN""}, {""id"": ""MetaCyc:PWY-5743"", ""source_sha256"": ""f32080596a30c23f3f9dcda28b4fa56af636d1a1b60828e6a07e75cc68142729"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""3-hydroxypropanoate cycle"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5743""}, {""id"": ""RHEA:20555"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""(S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-076_0489c42de343	GO:0043427	BFO:0000051	RHEA:22889	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:METHYLMALONYL-COA-MUT-RXN|MetaCyc:PWY-5743|RHEA:22889	Complete first-cycle chemistry; current Rhea equation and source-specific native mapping are independently grounded. Exact Chloroflexus catalytic protein attribution remains unresolved; no archaeal catalyst is substituted.	"[{""reference_id"": ""MetaCyc:PWY-5743"", ""source_assertion"": ""PWY-5743 explicitly lists METHYLMALONYL-COA-MUT-RXN as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-5743']/reaction-list/Reaction[@frameid='METHYLMALONYL-COA-MUT-RXN']""}, {""reference_id"": ""MetaCyc:METHYLMALONYL-COA-MUT-RXN"", ""source_assertion"": ""The native reaction links Rhea 22891; this supplies the reaction-family bridge, not an independent proof of physiological direction."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:22889"", ""source_assertion"": ""Rhea master 22888 explicitly links directed member 22889; its current substrate and product sides define the selected equation."", ""source_locator"": ""http://rdf.rhea-db.org/22888 rh:directionalReaction http://rdf.rhea-db.org/22889; http://rdf.rhea-db.org/22889 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:METHYLMALONYL-COA-MUT-RXN"", ""source_sha256"": ""322c68783b32c46bc6c9ba48baec241cbfc708fb7f2ace8dbff6dc501a12216e"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""METHYLMALONYL-COA-MUT-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:METHYLMALONYL-COA-MUT-RXN""}, {""id"": ""MetaCyc:PWY-5743"", ""source_sha256"": ""f32080596a30c23f3f9dcda28b4fa56af636d1a1b60828e6a07e75cc68142729"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""3-hydroxypropanoate cycle"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5743""}, {""id"": ""RHEA:22889"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""(R)-methylmalonyl-CoA => succinyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-077_69a606ad27b8	GO:0043427	BFO:0000051	RHEA:38256	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5743|MetaCyc:RXN-8964|RHEA:38256	Complete first-cycle chemistry; current Rhea equation and source-specific native mapping are independently grounded.	"[{""reference_id"": ""MetaCyc:PWY-5743"", ""source_assertion"": ""PWY-5743 explicitly lists RXN-8964 as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-5743']/reaction-list/Reaction[@frameid='RXN-8964']""}, {""reference_id"": ""MetaCyc:RXN-8964"", ""source_assertion"": ""The native reaction links Rhea 38258; this supplies the reaction-family bridge, not an independent proof of physiological direction."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:38256"", ""source_assertion"": ""Rhea master 38255 explicitly links directed member 38256; its current substrate and product sides define the selected equation."", ""source_locator"": ""http://rdf.rhea-db.org/38255 rh:directionalReaction http://rdf.rhea-db.org/38256; http://rdf.rhea-db.org/38256 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5743"", ""source_sha256"": ""f32080596a30c23f3f9dcda28b4fa56af636d1a1b60828e6a07e75cc68142729"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""3-hydroxypropanoate cycle"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5743""}, {""id"": ""MetaCyc:RXN-8964"", ""source_sha256"": ""4aeab4afc5d8a595c4c6af3594e66ed28d8ae84fb21f7c38ab35a5903205477d"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""RXN-8964"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8964""}, {""id"": ""RHEA:38256"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""succinyl-CoA + (S)-malate => (S)-malyl-CoA + succinate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-078_6ccdaa1ebce1	GO:0043427	BFO:0000051	RHEA:40524	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11418572|PMID:16547052|RHEA:40524	Complete first-cycle chemistry; current Rhea equation and source-specific native mapping are independently grounded. The physiological quinone remains a class; the original DCIP/PMS assay does not identify a specific natural quinone.	"[{""reference_id"": ""PMID:11418572"", ""source_assertion"": ""The first-cycle diagram and extract assays include succinate dehydrogenase and fumarate hydratase to regenerate malate; these are missing from the captured PWY-5743 reaction list."", ""source_locator"": ""Figure 1 activities 11–12; Materials and Methods, succinate dehydrogenase and fumarate hydratase assays; Results Table 1""}, {""reference_id"": ""RHEA:40524"", ""source_assertion"": ""Rhea master 40523 explicitly links directed member 40524; its current substrate and product sides define the selected equation."", ""source_locator"": ""http://rdf.rhea-db.org/40523 rh:directionalReaction http://rdf.rhea-db.org/40524; http://rdf.rhea-db.org/40524 rh:substrates; rh:products""}, {""reference_id"": ""PMID:16547052"", ""source_assertion"": ""The authors state that one reduced quinone is produced during succinate oxidation to fumarate in a first-cycle turnover; this is pathway stoichiometry, not a direct identification of the physiological quinone species."", ""source_locator"": ""Introduction, paragraph beginning One intriguing problem; Figure 1 activities 8–9""}]"	"[{""id"": ""PMID:11418572"", ""source_sha256"": ""e9720cd8f3f9a3d1bd96f541565728ae22decbbc143d1c71f4996202b67492e6"", ""source_version"": ""Complete original PMC HTML body; retrieved 2026-10-11; assay and strain scope retained at edge level"", ""title"": ""Autotrophic CO2 Fixation by Chloroflexus aurantiacus: Study of Glyoxylate Formation and Assimilation via the 3-Hydroxypropionate Cycle"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC95321/""}, {""id"": ""PMID:16547052"", ""source_sha256"": ""2006293b5d6658b1570326722eb1d0d2f89c00375e104cddb6fe18f1bb9ef24e"", ""source_version"": ""Complete original PMC HTML body; retrieved 2026-10-11; assay and strain scope retained at edge level"", ""title"": ""Properties of Succinyl-Coenzyme A:l-Malate Coenzyme A Transferase and Its Role in the Autotrophic 3-Hydroxypropionate Cycle of Chloroflexus aurantiacus"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1428406/""}, {""id"": ""RHEA:40524"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""a quinone + succinate => fumarate + a quinol"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-079_a4f2de177fd2	GO:0043427	BFO:0000051	RHEA:12462	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11418572|RHEA:12462	Complete first-cycle chemistry; current Rhea equation and source-specific native mapping are independently grounded. Exact Chloroflexus catalytic protein attribution remains unresolved; no archaeal catalyst is substituted.	"[{""reference_id"": ""PMID:11418572"", ""source_assertion"": ""The first-cycle diagram and extract assays include succinate dehydrogenase and fumarate hydratase to regenerate malate; these are missing from the captured PWY-5743 reaction list."", ""source_locator"": ""Figure 1 activities 11–12; Materials and Methods, succinate dehydrogenase and fumarate hydratase assays; Results Table 1""}, {""reference_id"": ""RHEA:12462"", ""source_assertion"": ""Rhea master 12460 explicitly links directed member 12462; its current substrate and product sides define the selected equation."", ""source_locator"": ""http://rdf.rhea-db.org/12460 rh:directionalReaction http://rdf.rhea-db.org/12462; http://rdf.rhea-db.org/12462 rh:substrates; rh:products""}]"	"[{""id"": ""PMID:11418572"", ""source_sha256"": ""e9720cd8f3f9a3d1bd96f541565728ae22decbbc143d1c71f4996202b67492e6"", ""source_version"": ""Complete original PMC HTML body; retrieved 2026-10-11; assay and strain scope retained at edge level"", ""title"": ""Autotrophic CO2 Fixation by Chloroflexus aurantiacus: Study of Glyoxylate Formation and Assimilation via the 3-Hydroxypropionate Cycle"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC95321/""}, {""id"": ""RHEA:12462"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""fumarate + H2O => (S)-malate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-080_af930830be80	GO:0043427	BFO:0000051	RHEA:16630	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:MALYL-COA-LYASE-RXN|MetaCyc:PWY-5743|RHEA:16630	Complete first-cycle chemistry; current Rhea equation and source-specific native mapping are independently grounded.	"[{""reference_id"": ""MetaCyc:PWY-5743"", ""source_assertion"": ""PWY-5743 explicitly lists MALYL-COA-LYASE-RXN as a reaction member."", ""source_locator"": ""Pathway[@frameid='PWY-5743']/reaction-list/Reaction[@frameid='MALYL-COA-LYASE-RXN']""}, {""reference_id"": ""MetaCyc:MALYL-COA-LYASE-RXN"", ""source_assertion"": ""The native reaction links Rhea 16632; this supplies the reaction-family bridge, not an independent proof of physiological direction."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:16630"", ""source_assertion"": ""Rhea master 16629 explicitly links directed member 16630; its current substrate and product sides define the selected equation."", ""source_locator"": ""http://rdf.rhea-db.org/16629 rh:directionalReaction http://rdf.rhea-db.org/16630; http://rdf.rhea-db.org/16630 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:MALYL-COA-LYASE-RXN"", ""source_sha256"": ""8ff780fbd01ec2e5b8051b0907a76b468a287107d5b9f0c6be85be26b9e8f6a8"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""MALYL-COA-LYASE-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MALYL-COA-LYASE-RXN""}, {""id"": ""MetaCyc:PWY-5743"", ""source_sha256"": ""f32080596a30c23f3f9dcda28b4fa56af636d1a1b60828e6a07e75cc68142729"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""3-hydroxypropanoate cycle"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5743""}, {""id"": ""RHEA:16630"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""(S)-malyl-CoA => glyoxylate + acetyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-081_976f29bbf0f8	UniProtKB:A9W9X0	pathwaymech:enables	RHEA:13502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:38572988|UniProtKB:A9W9X0	J-10-fl BC1 contains its own BCCP domain and forms a tetramer. This functional role does not assert a monomer or a fixed stoichiometry for the entire ACC assembly.	"[{""reference_id"": ""PMID:38572988"", ""source_assertion"": ""BC1 from J-10-fl (Caur_1378) is a 596-residue biotin carboxylase fused to BCCP. Biotinylation and carboxylation assays establish its BC/carrier functions; solution analysis supports a tetramer."", ""source_locator"": ""Results sections s2-1–s2-4; Materials and Methods s4-1, s4-3–s4-5, s4-8""}, {""reference_id"": ""UniProtKB:A9W9X0"", ""source_assertion"": ""The current Caur_1378 protein is biotin carboxylase, 596 residues, assigned to Chloroflexus aurantiacus J-10-fl."", ""source_locator"": ""/proteinDescription/recommendedName/fullName; /genes; /organism; /sequence/length""}]"	"[{""id"": ""PMID:38572988"", ""source_sha256"": ""8c8e6fcde50943d0fb4e771af6a39259541d5feb3d08747ed0077302616bddd6"", ""source_version"": ""Complete original PMC HTML body; retrieved 2026-10-11; assay and strain scope retained at edge level"", ""title"": ""Chloroflexus aurantiacus acetyl-CoA carboxylase evolves fused biotin carboxylase and biotin carboxyl carrier protein to complete carboxylation activity"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC11077971/""}, {""id"": ""UniProtKB:A9W9X0"", ""source_sha256"": ""5784ed335a0e688a35a9a7ba765695e73b97a8c06ed75fd883a7b17505bb77e4"", ""source_version"": ""UniProtKB 2026_03, 02-September-2026; complete original JSON response; retrieved 2026-10-11"", ""title"": ""biotin carboxylase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9W9X0.json""}]"	""
pathwaymech:GO_0043427_threehp-edge-082_848e2906e5f5	UniProtKB:A9WBQ8	pathwaymech:enables	RHEA:54729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:A9WBQ8	Current J-10-fl HAMAP assignment for the joint alpha/beta carboxyltransferase function; neither subunit is asserted independently sufficient. The 2024 paper reverses locus/chain names, so it is not direct exact-accession assay evidence here.	"[{""reference_id"": ""UniProtKB:A9WBQ8"", ""source_assertion"": ""The current catalytic annotation assigns the protein to Rhea 54728, transferring carboxyl from protein-bound carboxybiotin to acetyl-CoA. This is a HAMAP/inferred annotation, not a direct assay of this exact accession. Source annotation evidence: ECO:0000256."", ""source_locator"": ""/comments/0/texts; /comments/1/reaction; /comments/1/reaction/evidences""}]"	"[{""id"": ""UniProtKB:A9WBQ8"", ""source_sha256"": ""02c00ad67438d57e4bd45ded8fe0dc8a2513211e3c40d63c1c69f808e705e217"", ""source_version"": ""UniProtKB 2026_03, 02-September-2026; complete original JSON response; retrieved 2026-10-11"", ""title"": ""Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9WBQ8.json""}]"	""
pathwaymech:GO_0043427_threehp-edge-083_521eeb46299c	UniProtKB:A9WBQ9	pathwaymech:enables	RHEA:54729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:A9WBQ9	Current J-10-fl HAMAP assignment for the joint alpha/beta carboxyltransferase function; neither subunit is asserted independently sufficient. The 2024 paper reverses locus/chain names, so it is not direct exact-accession assay evidence here.	"[{""reference_id"": ""UniProtKB:A9WBQ9"", ""source_assertion"": ""The current catalytic annotation assigns the protein to Rhea 54728, transferring carboxyl from protein-bound carboxybiotin to acetyl-CoA. This is a HAMAP/inferred annotation, not a direct assay of this exact accession. Source annotation evidence: ECO:0000255."", ""source_locator"": ""/comments/0/texts; /comments/1/reaction; /comments/1/reaction/evidences""}]"	"[{""id"": ""UniProtKB:A9WBQ9"", ""source_sha256"": ""648805f6552d26a8fd62c5b84a8b7921d4a1c2d8302c9a15f50d64e7d1c1307a"", ""source_version"": ""UniProtKB 2026_03, 02-September-2026; complete original JSON response; retrieved 2026-10-11"", ""title"": ""Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9WBQ9.json""}]"	""
pathwaymech:GO_0043427_threehp-edge-084_71861b206fc3	MetaCyc:CPLX-7550	pathwaymech:catalyzes	RHEA:26448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7550|PMID:11948153	Bifunctional MCR from OK-70-fl. The native species-level complex is supported by the purified enzyme; its current J-10-fl component cross-reference is not equated to the OK-70-fl sequence. Physiological metal identity was not fixed.	"[{""reference_id"": ""PMID:11948153"", ""source_assertion"": ""Purified OK-70-fl MCR reduces malonyl-CoA with two NADPH via a freely trapped malonate-semialdehyde intermediate; the two NADPH-dependent partial reactions are stated separately."", ""source_locator"": ""Results sec23, transformation and stoichiometry; Discussion sec27""}, {""reference_id"": ""MetaCyc:CPLX-7550"", ""source_assertion"": ""The native complex describes bacterial bifunctional malonyl-CoA reductase and a two-subunit assembly."", ""source_locator"": ""Protein[@frameid=\""CPLX-7550\""]/comment; component""}]"	"[{""id"": ""MetaCyc:CPLX-7550"", ""source_sha256"": ""0ac61e64c1f21f367b0e3c8e960036424d8a4a0e49df8e469fd281b84892aa2c"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""malonyl CoA reductase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7550""}, {""id"": ""PMID:11948153"", ""source_sha256"": ""12ba378e029f66faa57dd0eb3c689efad7eddbf6e1d3adf3cd143fda9e6d39c0"", ""source_version"": ""Complete original PMC HTML body; retrieved 2026-10-11; assay and strain scope retained at edge level"", ""title"": ""Malonyl-Coenzyme A Reductase from Chloroflexus aurantiacus, a Key Enzyme of the 3-Hydroxypropionate Cycle for Autotrophic CO2 Fixation"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC134993/""}]"	""
pathwaymech:GO_0043427_threehp-edge-085_cedf1c3f37d1	MetaCyc:CPLX-7550	pathwaymech:catalyzes	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7550|PMID:11948153	Bifunctional MCR from OK-70-fl. The native species-level complex is supported by the purified enzyme; its current J-10-fl component cross-reference is not equated to the OK-70-fl sequence. Physiological metal identity was not fixed.	"[{""reference_id"": ""PMID:11948153"", ""source_assertion"": ""Purified OK-70-fl MCR reduces malonyl-CoA with two NADPH via a freely trapped malonate-semialdehyde intermediate; the two NADPH-dependent partial reactions are stated separately."", ""source_locator"": ""Results sec23, transformation and stoichiometry; Discussion sec27""}, {""reference_id"": ""MetaCyc:CPLX-7550"", ""source_assertion"": ""The native complex describes bacterial bifunctional malonyl-CoA reductase and a two-subunit assembly."", ""source_locator"": ""Protein[@frameid=\""CPLX-7550\""]/comment; component""}]"	"[{""id"": ""MetaCyc:CPLX-7550"", ""source_sha256"": ""0ac61e64c1f21f367b0e3c8e960036424d8a4a0e49df8e469fd281b84892aa2c"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""malonyl CoA reductase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7550""}, {""id"": ""PMID:11948153"", ""source_sha256"": ""12ba378e029f66faa57dd0eb3c689efad7eddbf6e1d3adf3cd143fda9e6d39c0"", ""source_version"": ""Complete original PMC HTML body; retrieved 2026-10-11; assay and strain scope retained at edge level"", ""title"": ""Malonyl-Coenzyme A Reductase from Chloroflexus aurantiacus, a Key Enzyme of the 3-Hydroxypropionate Cycle for Autotrophic CO2 Fixation"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC134993/""}]"	""
pathwaymech:GO_0043427_threehp-edge-086_13b49c3ca847	MetaCyc:CPLX-7550	BFO:0000051	UniProtKB:Q6QQP7	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11948153|UniProtKB:Q6QQP7	Two equivalent MCR subunits are supported by the purified OK-70-fl dimer estimate. Q6QQP7 is the separately submitted OK-70-fl sequence, not the distinct native J-10-fl A9WIU3 cross-reference.	"[{""reference_id"": ""PMID:11948153"", ""source_assertion"": ""The purified OK-70-fl enzyme has an approximately 145-kDa subunit and 300-kDa native mass, supporting a homodimer; its N-terminal sequence matches the reported SDR-like open reading frame."", ""source_locator"": ""Materials and Methods sec2; Results sec21; Discussion sec29""}, {""reference_id"": ""UniProtKB:Q6QQP7"", ""source_assertion"": ""The malonyl-CoA reductase sequence is attributed to OK-70-fl and EMBL AAS20429.1/AY530019; its source references link PMID11948153 and the January 2004 sequence submission."", ""source_locator"": ""/references/0; /references/1; /uniProtKBCrossReferences[database=EMBL]; /sequence""}]"	"[{""id"": ""PMID:11948153"", ""source_sha256"": ""12ba378e029f66faa57dd0eb3c689efad7eddbf6e1d3adf3cd143fda9e6d39c0"", ""source_version"": ""Complete original PMC HTML body; retrieved 2026-10-11; assay and strain scope retained at edge level"", ""title"": ""Malonyl-Coenzyme A Reductase from Chloroflexus aurantiacus, a Key Enzyme of the 3-Hydroxypropionate Cycle for Autotrophic CO2 Fixation"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC134993/""}, {""id"": ""UniProtKB:Q6QQP7"", ""source_sha256"": ""4379c5ce7466af5819a242392b851a3cbcc974e504dc36340613f05d482febd1"", ""source_version"": ""UniProtKB 2026_03, 02-September-2026; complete original JSON response; retrieved 2026-10-11"", ""title"": ""Malonyl-CoA reductase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q6QQP7.json""}]"	""
pathwaymech:GO_0043427_threehp-edge-087_bb191537b0f9	UniProtKB:Q8VRG6	pathwaymech:enables	RHEA:26535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7552|MetaCyc:MONOMER-13612|UniProtKB:Q8VRG6	Functional role of the OK-70-fl trifunctional PCS. Native assembly is three or four subunits; no unique stoichiometry or monomer sufficiency is asserted. The automated acetate-CoA-ligase name is not used to redefine its inspected pathway activity.	"[{""reference_id"": ""MetaCyc:CPLX-7552"", ""source_assertion"": ""The native PCS complex catalyzes the three reactions that convert 3-hydroxypropanoate to propanoyl-CoA and describes a native assembly of three or four subunits."", ""source_locator"": ""Protein[@frameid=\""CPLX-7552\""]/comment; catalyzes""}, {""reference_id"": ""MetaCyc:MONOMER-13612"", ""source_assertion"": ""The native PCS subunit explicitly links both UniProt Q8VRG6 and A9WEU4 and belongs to the PCS complex."", ""source_locator"": ""Protein[@frameid=\""MONOMER-13612\""]/dblink[dblink-db=\""UNIPROT\""]; component-of""}, {""reference_id"": ""UniProtKB:Q8VRG6"", ""source_assertion"": ""The sequence record attributes the protein to OK-70-fl and links the primary PCS paper PMID11821399 and nucleotide accession AF445079."", ""source_locator"": ""/references; /uniProtKBCrossReferences[database=EMBL]; /sequence""}]"	"[{""id"": ""MetaCyc:CPLX-7552"", ""source_sha256"": ""f90283f0a3ab61d6ef9db72355a659e7380d762ba09660fc8a973dd8a7c5cbf6"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""propionyl-CoA synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7552""}, {""id"": ""MetaCyc:MONOMER-13612"", ""source_sha256"": ""f41e27eb69eb3c1949db94906081c3be82ba75a84701d3e997f2c9a684b4f99b"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""propionyl-CoA synthase subunit"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-13612""}, {""id"": ""UniProtKB:Q8VRG6"", ""source_sha256"": ""0f4a1210bd6445758b8d59a05c6d4bf6598d629f95fa55abaee4eb77f994f3dd"", ""source_version"": ""UniProtKB 2026_03, 02-September-2026; complete original JSON response; retrieved 2026-10-11"", ""title"": ""acetate--CoA ligase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q8VRG6.json""}]"	""
pathwaymech:GO_0043427_threehp-edge-088_c779f28db3e0	UniProtKB:Q8VRG6	pathwaymech:enables	RHEA:26519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7552|MetaCyc:MONOMER-13612|UniProtKB:Q8VRG6	Functional role of the OK-70-fl trifunctional PCS. Native assembly is three or four subunits; no unique stoichiometry or monomer sufficiency is asserted. The automated acetate-CoA-ligase name is not used to redefine its inspected pathway activity.	"[{""reference_id"": ""MetaCyc:CPLX-7552"", ""source_assertion"": ""The native PCS complex catalyzes the three reactions that convert 3-hydroxypropanoate to propanoyl-CoA and describes a native assembly of three or four subunits."", ""source_locator"": ""Protein[@frameid=\""CPLX-7552\""]/comment; catalyzes""}, {""reference_id"": ""MetaCyc:MONOMER-13612"", ""source_assertion"": ""The native PCS subunit explicitly links both UniProt Q8VRG6 and A9WEU4 and belongs to the PCS complex."", ""source_locator"": ""Protein[@frameid=\""MONOMER-13612\""]/dblink[dblink-db=\""UNIPROT\""]; component-of""}, {""reference_id"": ""UniProtKB:Q8VRG6"", ""source_assertion"": ""The sequence record attributes the protein to OK-70-fl and links the primary PCS paper PMID11821399 and nucleotide accession AF445079."", ""source_locator"": ""/references; /uniProtKBCrossReferences[database=EMBL]; /sequence""}]"	"[{""id"": ""MetaCyc:CPLX-7552"", ""source_sha256"": ""f90283f0a3ab61d6ef9db72355a659e7380d762ba09660fc8a973dd8a7c5cbf6"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""propionyl-CoA synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7552""}, {""id"": ""MetaCyc:MONOMER-13612"", ""source_sha256"": ""f41e27eb69eb3c1949db94906081c3be82ba75a84701d3e997f2c9a684b4f99b"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""propionyl-CoA synthase subunit"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-13612""}, {""id"": ""UniProtKB:Q8VRG6"", ""source_sha256"": ""0f4a1210bd6445758b8d59a05c6d4bf6598d629f95fa55abaee4eb77f994f3dd"", ""source_version"": ""UniProtKB 2026_03, 02-September-2026; complete original JSON response; retrieved 2026-10-11"", ""title"": ""acetate--CoA ligase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q8VRG6.json""}]"	""
pathwaymech:GO_0043427_threehp-edge-089_53a08cda88e4	UniProtKB:Q8VRG6	pathwaymech:enables	RHEA:26456	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7552|MetaCyc:MONOMER-13612|UniProtKB:Q8VRG6	Functional role of the OK-70-fl trifunctional PCS. Native assembly is three or four subunits; no unique stoichiometry or monomer sufficiency is asserted. The automated acetate-CoA-ligase name is not used to redefine its inspected pathway activity.	"[{""reference_id"": ""MetaCyc:CPLX-7552"", ""source_assertion"": ""The native PCS complex catalyzes the three reactions that convert 3-hydroxypropanoate to propanoyl-CoA and describes a native assembly of three or four subunits."", ""source_locator"": ""Protein[@frameid=\""CPLX-7552\""]/comment; catalyzes""}, {""reference_id"": ""MetaCyc:MONOMER-13612"", ""source_assertion"": ""The native PCS subunit explicitly links both UniProt Q8VRG6 and A9WEU4 and belongs to the PCS complex."", ""source_locator"": ""Protein[@frameid=\""MONOMER-13612\""]/dblink[dblink-db=\""UNIPROT\""]; component-of""}, {""reference_id"": ""UniProtKB:Q8VRG6"", ""source_assertion"": ""The sequence record attributes the protein to OK-70-fl and links the primary PCS paper PMID11821399 and nucleotide accession AF445079."", ""source_locator"": ""/references; /uniProtKBCrossReferences[database=EMBL]; /sequence""}]"	"[{""id"": ""MetaCyc:CPLX-7552"", ""source_sha256"": ""f90283f0a3ab61d6ef9db72355a659e7380d762ba09660fc8a973dd8a7c5cbf6"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""propionyl-CoA synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7552""}, {""id"": ""MetaCyc:MONOMER-13612"", ""source_sha256"": ""f41e27eb69eb3c1949db94906081c3be82ba75a84701d3e997f2c9a684b4f99b"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""propionyl-CoA synthase subunit"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-13612""}, {""id"": ""UniProtKB:Q8VRG6"", ""source_sha256"": ""0f4a1210bd6445758b8d59a05c6d4bf6598d629f95fa55abaee4eb77f994f3dd"", ""source_version"": ""UniProtKB 2026_03, 02-September-2026; complete original JSON response; retrieved 2026-10-11"", ""title"": ""acetate--CoA ligase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q8VRG6.json""}]"	""
pathwaymech:GO_0043427_threehp-edge-090_f32414c77f20	MetaCyc:CPLX-7546	pathwaymech:catalyzes	RHEA:38256	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7546|PMID:16547052	The purified and coexpressed OK-70-fl SmtAB complex transfers CoA from succinyl-CoA to (S)-malate. Magnesium in the coupled assay serves the downstream lyase, not SmtAB.	"[{""reference_id"": ""PMID:16547052"", ""source_assertion"": ""Coexpression of SmtA and SmtB yielded succinyl-CoA:L-malate CoA transferase; purified enzyme forms malyl-CoA and succinate. Neither isolated subunit was active, and mixing did not reconstitute activity."", ""source_locator"": ""Results sec39–sec40; Table 3""}, {""reference_id"": ""MetaCyc:CPLX-7546"", ""source_assertion"": ""The native species-level complex is succinyl CoA:L-malate CoA transferase and comprises six copies of its heterodimer."", ""source_locator"": ""Protein[@frameid=\""CPLX-7546\""]/common-name; component""}]"	"[{""id"": ""MetaCyc:CPLX-7546"", ""source_sha256"": ""6f5c04288feb37c5e480fccf486e6c7b20a1ab5befa5c76c4b59139306c3c2db"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""succinyl CoA:L-malate CoA transferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7546""}, {""id"": ""PMID:16547052"", ""source_sha256"": ""2006293b5d6658b1570326722eb1d0d2f89c00375e104cddb6fe18f1bb9ef24e"", ""source_version"": ""Complete original PMC HTML body; retrieved 2026-10-11; assay and strain scope retained at edge level"", ""title"": ""Properties of Succinyl-Coenzyme A:l-Malate Coenzyme A Transferase and Its Role in the Autotrophic 3-Hydroxypropionate Cycle of Chloroflexus aurantiacus"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1428406/""}]"	""
pathwaymech:GO_0043427_threehp-edge-091_ea0778177982	MetaCyc:CPLX-7546	BFO:0000051	MetaCyc:CPLX-7548	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7546|PMID:16547052	Six alpha/beta heterodimers in the source model; primary recombinant mass 550 +/- 50 kDa best fits (alpha beta)6. This is 12 polypeptide chains, not six identical subunits.	"[{""reference_id"": ""MetaCyc:CPLX-7546"", ""source_assertion"": ""The complex lists CPLX-7548 with component coefficient 6."", ""source_locator"": ""Protein[@frameid=\""CPLX-7546\""]/component""}, {""reference_id"": ""PMID:16547052"", ""source_assertion"": ""Gel filtration gave 550 +/- 50 kDa for the recombinant complex, best fitting six alpha/beta heterodimers; both chains are jointly required."", ""source_locator"": ""Results sec39–sec40; Table 3""}]"	"[{""id"": ""MetaCyc:CPLX-7546"", ""source_sha256"": ""6f5c04288feb37c5e480fccf486e6c7b20a1ab5befa5c76c4b59139306c3c2db"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""succinyl CoA:L-malate CoA transferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7546""}, {""id"": ""PMID:16547052"", ""source_sha256"": ""2006293b5d6658b1570326722eb1d0d2f89c00375e104cddb6fe18f1bb9ef24e"", ""source_version"": ""Complete original PMC HTML body; retrieved 2026-10-11; assay and strain scope retained at edge level"", ""title"": ""Properties of Succinyl-Coenzyme A:l-Malate Coenzyme A Transferase and Its Role in the Autotrophic 3-Hydroxypropionate Cycle of Chloroflexus aurantiacus"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1428406/""}]"	""
pathwaymech:GO_0043427_threehp-edge-092_1e6fd41e3f6b	MetaCyc:CPLX-7548	BFO:0000051	UniProtKB:Q1KLK1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:16547052|UniProtKB:Q1KLK1	One selected OK-70-fl chain per alpha/beta heterodimer. Its identity comes from the exact primary-linked sequence record, not an equivalence to the native J-10-fl cross-reference.	"[{""reference_id"": ""UniProtKB:Q1KLK1"", ""source_assertion"": ""This Smt subunit is assigned to DSM636/OK-70-fl by its PMID16547052 sequence reference, and the experimentally supported subunit annotation describes six alpha/beta heterodimers. Source annotation evidence: ECO:0000269."", ""source_locator"": ""/references/0; /comments/4/texts; /sequence""}, {""reference_id"": ""PMID:16547052"", ""source_assertion"": ""The experiment cloned and coexpressed the two OK-70-fl Smt chains; their subunit masses and N-terminal sequences identify the alpha/beta transferase."", ""source_locator"": ""Methods sec2, sec14–sec16; Results sec38–sec40""}]"	"[{""id"": ""PMID:16547052"", ""source_sha256"": ""2006293b5d6658b1570326722eb1d0d2f89c00375e104cddb6fe18f1bb9ef24e"", ""source_version"": ""Complete original PMC HTML body; retrieved 2026-10-11; assay and strain scope retained at edge level"", ""title"": ""Properties of Succinyl-Coenzyme A:l-Malate Coenzyme A Transferase and Its Role in the Autotrophic 3-Hydroxypropionate Cycle of Chloroflexus aurantiacus"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1428406/""}, {""id"": ""UniProtKB:Q1KLK1"", ""source_sha256"": ""83ae45cafe2c15d96e9e6ddc04787e3970cbd81dd40fc131afeb96507840d4fb"", ""source_version"": ""UniProtKB 2026_03, 02-September-2026; complete original JSON response; retrieved 2026-10-11"", ""title"": ""Succinyl-CoA--L-malate CoA-transferase alpha subunit"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q1KLK1.json""}]"	""
pathwaymech:GO_0043427_threehp-edge-093_de5606b2195e	MetaCyc:CPLX-7548	BFO:0000051	UniProtKB:Q1KLK0	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:16547052|UniProtKB:Q1KLK0	One selected OK-70-fl chain per alpha/beta heterodimer. Its identity comes from the exact primary-linked sequence record, not an equivalence to the native J-10-fl cross-reference.	"[{""reference_id"": ""UniProtKB:Q1KLK0"", ""source_assertion"": ""This Smt subunit is assigned to DSM636/OK-70-fl by its PMID16547052 sequence reference, and the experimentally supported subunit annotation describes six alpha/beta heterodimers. Source annotation evidence: ECO:0000269."", ""source_locator"": ""/references/0; /comments/4/texts; /sequence""}, {""reference_id"": ""PMID:16547052"", ""source_assertion"": ""The experiment cloned and coexpressed the two OK-70-fl Smt chains; their subunit masses and N-terminal sequences identify the alpha/beta transferase."", ""source_locator"": ""Methods sec2, sec14–sec16; Results sec38–sec40""}]"	"[{""id"": ""PMID:16547052"", ""source_sha256"": ""2006293b5d6658b1570326722eb1d0d2f89c00375e104cddb6fe18f1bb9ef24e"", ""source_version"": ""Complete original PMC HTML body; retrieved 2026-10-11; assay and strain scope retained at edge level"", ""title"": ""Properties of Succinyl-Coenzyme A:l-Malate Coenzyme A Transferase and Its Role in the Autotrophic 3-Hydroxypropionate Cycle of Chloroflexus aurantiacus"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1428406/""}, {""id"": ""UniProtKB:Q1KLK0"", ""source_sha256"": ""d56cb4a7344cc5ce3aabc059c998243adfc08d65e12feaa5082196d339248eaa"", ""source_version"": ""UniProtKB 2026_03, 02-September-2026; complete original JSON response; retrieved 2026-10-11"", ""title"": ""Succinyl-CoA--L-malate CoA-transferase beta subunit"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q1KLK0.json""}]"	""
pathwaymech:GO_0043427_threehp-edge-094_a1353a9b495b	UniProtKB:A9WDT7	pathwaymech:enables	RHEA:40524	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:A9WDT7	J-10-fl annotated SDH catalytic component; its ARBA inference does not establish an exact assayed OK-70-fl protein, a complete isolated enzyme, or the physiological quinone species.	"[{""reference_id"": ""UniProtKB:A9WDT7"", ""source_assertion"": ""The catalytic annotation assigns the generic quinone-dependent succinate-to-fumarate reaction Rhea40523 with ARBA evidence. Source annotation evidence: ECO:0000256."", ""source_locator"": ""/comments/0/reaction; /comments/0/reaction/evidences""}]"	"[{""id"": ""UniProtKB:A9WDT7"", ""source_sha256"": ""69145061f564e2ae99c0d1ea2396913f441736c91e6b64c584dc565c05316329"", ""source_version"": ""UniProtKB 2026_03, 02-September-2026; complete original JSON response; retrieved 2026-10-11"", ""title"": ""succinate dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9WDT7.json""}]"	""
pathwaymech:GO_0043427_threehp-edge-095_c769af2d9efd	MetaCyc:CPLX-7549	pathwaymech:catalyzes	RHEA:16630	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12374834|UniProtKB:S5N020	Hexameric OK-70-fl Mcl cleaves (S)-malyl-CoA to acetyl-CoA and glyoxylate. Its other two reactions belong to the separate glyoxylate-assimilation cycle.	"[{""reference_id"": ""UniProtKB:S5N020"", ""source_assertion"": ""The directly supported first catalytic activity is Rhea16629, cleavage of (S)-malyl-CoA to glyoxylate and acetyl-CoA. Source annotation evidence: ECO:0000269."", ""source_locator"": ""/comments/0/texts; /comments/1/reaction""}, {""reference_id"": ""PMID:12374834"", ""source_assertion"": ""Purified and recombinant OK-70-fl L-malyl-CoA lyase catalyze the reversible malyl-CoA cleavage reaction that regenerates acetyl-CoA in the first cycle."", ""source_locator"": ""Results sec28; Figure 1; Methods sec2 and sec12""}]"	"[{""id"": ""PMID:12374834"", ""source_sha256"": ""a3ad8f6f31c327d5b642231749e3c1f946fa4e9bbe133430de5e4b2409260292"", ""source_version"": ""Complete original PMC HTML body; retrieved 2026-10-11; assay and strain scope retained at edge level"", ""title"": ""l-Malyl-Coenzyme A Lyase/β-Methylmalyl-Coenzyme A Lyase from Chloroflexus aurantiacus, a Bifunctional Enzyme Involved in Autotrophic CO2 Fixation"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC135395/""}, {""id"": ""UniProtKB:S5N020"", ""source_sha256"": ""ee8c48a604f28f3967d40526eb452abb51d770277fc49caf368aaa274c581e02"", ""source_version"": ""UniProtKB 2026_03, 02-September-2026; complete original JSON response; retrieved 2026-10-11"", ""title"": ""Malyl-CoA/beta-methylmalyl-CoA/citramalyl-CoA lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/S5N020.json""}]"	""
pathwaymech:GO_0043427_threehp-edge-096_1308eaa4e3ec	MetaCyc:CPLX-7549	BFO:0000051	UniProtKB:S5N020	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7549|MetaCyc:MONOMER-13604|PMID:24206647|UniProtKB:A9WC35|UniProtKB:S5N020	Six identical Mcl chains. The exact S5N020 sequence equals native-mapped A9WC35, but strain names remain distinct; 2013 directly studies the OK-70-fl construct and supports the hexamer by solution and structural measurements.	"[{""reference_id"": ""MetaCyc:CPLX-7549"", ""source_assertion"": ""The native Mcl complex lists six copies of MONOMER-13604."", ""source_locator"": ""Protein[@frameid=\""CPLX-7549\""]/component""}, {""reference_id"": ""MetaCyc:MONOMER-13604"", ""source_assertion"": ""The native Mcl subunit explicitly links UniProt A9WC35."", ""source_locator"": ""Protein[@frameid=\""MONOMER-13604\""]/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""PMID:24206647"", ""source_assertion"": ""OK-70-fl Mcl (AGR55786; Table 1) eluted at 228 +/- 15 kDa and crystallized as a hexamer; the structure is a dimer of trimers with active-site contributions from neighboring chains."", ""source_locator"": ""Table 1; Results sec6 and sec9; Methods sec18""}, {""reference_id"": ""UniProtKB:A9WC35"", ""source_assertion"": ""The current native-linked J-10-fl entry supplies its 348-residue Mcl sequence as the independent comparison source."", ""source_locator"": ""/organism; /sequence""}, {""reference_id"": ""UniProtKB:S5N020"", ""source_assertion"": ""The exact OK-70-fl sequence record maps AGR55786.1 and describes a homohexamer, a dimer of trimers, with experimental evidence. Source annotation evidence: ECO:0000269."", ""source_locator"": ""/references/0–3; /uniProtKBCrossReferences[database=EMBL]; /sequence; /comments/7/texts""}]"	"[{""id"": ""MetaCyc:CPLX-7549"", ""source_sha256"": ""d57f9f742ed9a5d34f892c430529186b7f3f6d83d516bf4b0301c402aca2e30f"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""L-malyl CoA lyase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7549""}, {""id"": ""MetaCyc:MONOMER-13604"", ""source_sha256"": ""912acc5803663610d2f0db16ae70e4ac52cf868c2ddcb8701a86b78ca4b43ad2"", ""source_version"": ""MetaCyc 22.5; complete original native XML body; retrieved 2026-10-11"", ""title"": ""L-malyl CoA lyase subunit"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-13604""}, {""id"": ""PMID:24206647"", ""source_sha256"": ""6d3105856a321b6d6977c03686e497c97c6c965cd4da532049c538d4d7af34ad"", ""source_version"": ""Complete original PMC HTML body; retrieved 2026-10-11; assay and strain scope retained at edge level"", ""title"": ""The crystal structures of the tri-functional Chloroflexus aurantiacus and bi-functional Rhodobacter sphaeroides malyl-CoA lyases and comparison with CitE-like superfamily enzymes and malate synthases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3832036/""}, {""id"": ""UniProtKB:A9WC35"", ""source_sha256"": ""986814a8c9cb8f73b7905c667ed76780c4c8ca810ee19e8fff5b212b849ca963"", ""source_version"": ""UniProtKB 2026_03; complete original JSON response; retrieved 2026-10-11; comparison source, not selected protein identity"", ""title"": ""Malyl-CoA lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9WC35.json""}, {""id"": ""UniProtKB:S5N020"", ""source_sha256"": ""ee8c48a604f28f3967d40526eb452abb51d770277fc49caf368aaa274c581e02"", ""source_version"": ""UniProtKB 2026_03, 02-September-2026; complete original JSON response; retrieved 2026-10-11"", ""title"": ""Malyl-CoA/beta-methylmalyl-CoA/citramalyl-CoA lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/S5N020.json""}]"	""
pathwaymech:GO_0043427_threehp-edge-097_d245572e6896	UniProtKB:A9W9X0	pathwaymech:has_cofactor	CHEBI:57586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:A9W9X0	Evidence tier and protein scope are retained; chemical identity denotes the cofactor rather than an extra consumed substrate.	"[{""reference_id"": ""UniProtKB:A9W9X0"", ""source_assertion"": ""The current biotin-carboxylase annotation specifies biotin as cofactor with ARBA evidence; in the selected mechanism its covalently attached carrier states are explicit. Source annotation evidence: ECO:0000256."", ""source_locator"": ""/comments/0/cofactors""}]"	"[{""id"": ""UniProtKB:A9W9X0"", ""source_sha256"": ""5784ed335a0e688a35a9a7ba765695e73b97a8c06ed75fd883a7b17505bb77e4"", ""source_version"": ""UniProtKB 2026_03, 02-September-2026; complete original JSON response; retrieved 2026-10-11"", ""title"": ""biotin carboxylase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9W9X0.json""}]"	""
pathwaymech:GO_0043427_threehp-edge-098_515f1153b53e	UniProtKB:A9WBQ9	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:A9WBQ9	Evidence tier and protein scope are retained; chemical identity denotes the cofactor rather than an extra consumed substrate.	"[{""reference_id"": ""UniProtKB:A9WBQ9"", ""source_assertion"": ""The current beta-chain annotation assigns one zinc ion per subunit by HAMAP; this is not a directly measured 2024 J-10-fl metal requirement. Source annotation evidence: ECO:0000255."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}]"	"[{""id"": ""UniProtKB:A9WBQ9"", ""source_sha256"": ""648805f6552d26a8fd62c5b84a8b7921d4a1c2d8302c9a15f50d64e7d1c1307a"", ""source_version"": ""UniProtKB 2026_03, 02-September-2026; complete original JSON response; retrieved 2026-10-11"", ""title"": ""Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9WBQ9.json""}]"	""
pathwaymech:GO_0043427_threehp-edge-099_064c241dee4e	UniProtKB:A9WDT7	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:A9WDT7	Evidence tier and protein scope are retained; chemical identity denotes the cofactor rather than an extra consumed substrate.	"[{""reference_id"": ""UniProtKB:A9WDT7"", ""source_assertion"": ""The current SDH annotation assigns FAD as cofactor with ARBA evidence. Source annotation evidence: ECO:0000256."", ""source_locator"": ""/comments/1/cofactors""}]"	"[{""id"": ""UniProtKB:A9WDT7"", ""source_sha256"": ""69145061f564e2ae99c0d1ea2396913f441736c91e6b64c584dc565c05316329"", ""source_version"": ""UniProtKB 2026_03, 02-September-2026; complete original JSON response; retrieved 2026-10-11"", ""title"": ""succinate dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9WDT7.json""}]"	""
pathwaymech:GO_0043427_threehp-edge-100_779d3cbcb9ff	MetaCyc:CPLX-7549	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12374834|UniProtKB:S5N020	Alternative divalent-metal support, not a requirement to bind both metals simultaneously.	"[{""reference_id"": ""UniProtKB:S5N020"", ""source_assertion"": ""The Mcl cofactor annotation includes magnesium as a divalent cofactor with experimental evidence. Source annotation evidence: ECO:0000269."", ""source_locator"": ""/comments/4/cofactors; /comments/4/note""}, {""reference_id"": ""PMID:12374834"", ""source_assertion"": ""The purified lyase requires divalent metal; EDTA-treated enzyme is restored by Mg2+, while Mn2+ gives partial activity in the tested preparation."", ""source_locator"": ""Results sec28, metal-dependence experiment""}]"	"[{""id"": ""PMID:12374834"", ""source_sha256"": ""a3ad8f6f31c327d5b642231749e3c1f946fa4e9bbe133430de5e4b2409260292"", ""source_version"": ""Complete original PMC HTML body; retrieved 2026-10-11; assay and strain scope retained at edge level"", ""title"": ""l-Malyl-Coenzyme A Lyase/β-Methylmalyl-Coenzyme A Lyase from Chloroflexus aurantiacus, a Bifunctional Enzyme Involved in Autotrophic CO2 Fixation"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC135395/""}, {""id"": ""UniProtKB:S5N020"", ""source_sha256"": ""ee8c48a604f28f3967d40526eb452abb51d770277fc49caf368aaa274c581e02"", ""source_version"": ""UniProtKB 2026_03, 02-September-2026; complete original JSON response; retrieved 2026-10-11"", ""title"": ""Malyl-CoA/beta-methylmalyl-CoA/citramalyl-CoA lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/S5N020.json""}]"	""
pathwaymech:GO_0043427_threehp-edge-101_cae15cefe30b	MetaCyc:CPLX-7549	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12374834|UniProtKB:S5N020	Alternative divalent-metal support, not a requirement to bind both metals simultaneously.	"[{""reference_id"": ""UniProtKB:S5N020"", ""source_assertion"": ""The Mcl cofactor annotation includes manganese as a divalent cofactor with experimental evidence. Source annotation evidence: ECO:0000269."", ""source_locator"": ""/comments/4/cofactors; /comments/4/note""}, {""reference_id"": ""PMID:12374834"", ""source_assertion"": ""The purified lyase requires divalent metal; EDTA-treated enzyme is restored by Mg2+, while Mn2+ gives partial activity in the tested preparation."", ""source_locator"": ""Results sec28, metal-dependence experiment""}]"	"[{""id"": ""PMID:12374834"", ""source_sha256"": ""a3ad8f6f31c327d5b642231749e3c1f946fa4e9bbe133430de5e4b2409260292"", ""source_version"": ""Complete original PMC HTML body; retrieved 2026-10-11; assay and strain scope retained at edge level"", ""title"": ""l-Malyl-Coenzyme A Lyase/β-Methylmalyl-Coenzyme A Lyase from Chloroflexus aurantiacus, a Bifunctional Enzyme Involved in Autotrophic CO2 Fixation"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC135395/""}, {""id"": ""UniProtKB:S5N020"", ""source_sha256"": ""ee8c48a604f28f3967d40526eb452abb51d770277fc49caf368aaa274c581e02"", ""source_version"": ""UniProtKB 2026_03, 02-September-2026; complete original JSON response; retrieved 2026-10-11"", ""title"": ""Malyl-CoA/beta-methylmalyl-CoA/citramalyl-CoA lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/S5N020.json""}]"	""
pathwaymech:GO_0043427_threehp-edge-102_4364dfea6f65	UniProtKB:Q8VRG6	pathwaymech:has_cofactor	CHEBI:29103	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11821399	Assayed potassium dependence of the OK-70-fl PCS preparation; partial substitution by other monovalent ions does not imply universal ion equivalence.	"[{""reference_id"": ""PMID:11821399"", ""source_assertion"": ""Potassium omission and titration establish PCS potassium dependence; related monovalent ions partially substitute."", ""source_locator"": ""Results, Catalytic Properties of Propionyl-CoA Synthase; Methods, Characterization of the Enzyme""}]"	"[{""id"": ""PMID:11821399"", ""source_version"": ""Original 2002 paper inspected through ResearchGate web rendering on 2026-10-11; publisher/body downloads unavailable; no original-body SHA is asserted"", ""title"": ""Propionyl-coenzyme A synthase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO2 fixation"", ""url"": ""https://doi.org/10.1074/jbc.M110802200""}]"	""
pathwaymech:GO_0043427_threehp-edge-103_526fdb599edf	UniProtKB:Q8VRG6	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11821399	Magnesium is the experimentally reported PCS cocatalyst in MgATP-dependent assays; this does not assert a separately isolated metal-binding site.	"[{""reference_id"": ""PMID:11821399"", ""source_assertion"": ""The authors tested magnesium dependence by omission and add-back and list magnesium as a cocatalyst."", ""source_locator"": ""Methods, Characterization of the Enzyme; Table III, Cocatalysts""}]"	"[{""id"": ""PMID:11821399"", ""source_version"": ""Original 2002 paper inspected through ResearchGate web rendering on 2026-10-11; publisher/body downloads unavailable; no original-body SHA is asserted"", ""title"": ""Propionyl-coenzyme A synthase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO2 fixation"", ""url"": ""https://doi.org/10.1074/jbc.M110802200""}]"	""
pathwaymech:GO_0043427_threehp-edge-104_2b2cf957adc3	RHEA:10750	RO:0002413	RHEA:13502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750|RHEA:13502	The shared chemical state is CHEBI:17544; this asserts material continuity, not substrate channeling or compulsory kinetic order.	"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Directed reaction 10750 produces CHEBI:17544."", ""source_locator"": ""http://rdf.rhea-db.org/10750 rh:products; corresponding side rh:contains1 / rh:compound / rh:accession""}, {""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Directed reaction 13502 consumes CHEBI:17544."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:substrates; corresponding side rh:contains1 / rh:compound / rh:accession""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""CO2 + H2O => hydrogencarbonate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-105_52e755d1aa75	RHEA:10750	RO:0002413	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750|RHEA:23721	The shared chemical state is CHEBI:17544; this asserts material continuity, not substrate channeling or compulsory kinetic order.	"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Directed reaction 10750 produces CHEBI:17544."", ""source_locator"": ""http://rdf.rhea-db.org/10750 rh:products; corresponding side rh:contains1 / rh:compound / rh:accession""}, {""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Directed reaction 23721 consumes CHEBI:17544."", ""source_locator"": ""http://rdf.rhea-db.org/23721 rh:substrates; corresponding side rh:contains1 / rh:compound / rh:accession""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""CO2 + H2O => hydrogencarbonate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-106_9f776193b941	RHEA:13502	RO:0002413	RHEA:54729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13502|RHEA:54729	The shared chemical state is RHEA-COMP:10506; this asserts material continuity, not substrate channeling or compulsory kinetic order.	"[{""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Directed reaction 13502 produces RHEA-COMP:10506."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:products; corresponding side rh:contains1 / rh:compound / rh:accession""}, {""reference_id"": ""RHEA:54729"", ""source_assertion"": ""Directed reaction 54729 consumes RHEA-COMP:10506."", ""source_locator"": ""http://rdf.rhea-db.org/54729 rh:substrates; corresponding side rh:contains1 / rh:compound / rh:accession""}]"	"[{""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:54729"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA => N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-107_e7cc585249a0	RHEA:54729	RO:0002413	RHEA:13502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13502|RHEA:54729	The shared chemical state is RHEA-COMP:10505; this asserts material continuity, not substrate channeling or compulsory kinetic order.	"[{""reference_id"": ""RHEA:54729"", ""source_assertion"": ""Directed reaction 54729 produces RHEA-COMP:10505."", ""source_locator"": ""http://rdf.rhea-db.org/54729 rh:products; corresponding side rh:contains1 / rh:compound / rh:accession""}, {""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Directed reaction 13502 consumes RHEA-COMP:10505."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:substrates; corresponding side rh:contains1 / rh:compound / rh:accession""}]"	"[{""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:54729"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA => N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-108_94ab29fc3693	RHEA:54729	RO:0002413	RHEA:26448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448|RHEA:54729	The shared chemical state is CHEBI:57384; this asserts material continuity, not substrate channeling or compulsory kinetic order.	"[{""reference_id"": ""RHEA:54729"", ""source_assertion"": ""Directed reaction 54729 produces CHEBI:57384."", ""source_locator"": ""http://rdf.rhea-db.org/54729 rh:products; corresponding side rh:contains1 / rh:compound / rh:accession""}, {""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Directed reaction 26448 consumes CHEBI:57384."", ""source_locator"": ""http://rdf.rhea-db.org/26448 rh:substrates; corresponding side rh:contains1 / rh:compound / rh:accession""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""malonyl-CoA + NADPH + H(+) => 3-oxopropanoate + NADP(+) + CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:54729"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA => N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-109_c6f5ff026fe9	RHEA:26448	RO:0002413	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440|RHEA:26448	The shared chemical state is CHEBI:33190; this asserts material continuity, not substrate channeling or compulsory kinetic order.	"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Directed reaction 26448 produces CHEBI:33190."", ""source_locator"": ""http://rdf.rhea-db.org/26448 rh:products; corresponding side rh:contains1 / rh:compound / rh:accession""}, {""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Directed reaction 26440 consumes CHEBI:33190."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:substrates; corresponding side rh:contains1 / rh:compound / rh:accession""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""malonyl-CoA + NADPH + H(+) => 3-oxopropanoate + NADP(+) + CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-110_ceb07b62164e	RHEA:26440	RO:0002413	RHEA:26535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440|RHEA:26535	The shared chemical state is CHEBI:16510; this asserts material continuity, not substrate channeling or compulsory kinetic order.	"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Directed reaction 26440 produces CHEBI:16510."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:products; corresponding side rh:contains1 / rh:compound / rh:accession""}, {""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Directed reaction 26535 consumes CHEBI:16510."", ""source_locator"": ""http://rdf.rhea-db.org/26535 rh:substrates; corresponding side rh:contains1 / rh:compound / rh:accession""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-111_9e81b608ae66	RHEA:26535	RO:0002413	RHEA:26519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26519|RHEA:26535	The shared chemical state is CHEBI:58528; this asserts material continuity, not substrate channeling or compulsory kinetic order.	"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Directed reaction 26535 produces CHEBI:58528."", ""source_locator"": ""http://rdf.rhea-db.org/26535 rh:products; corresponding side rh:contains1 / rh:compound / rh:accession""}, {""reference_id"": ""RHEA:26519"", ""source_assertion"": ""Directed reaction 26519 consumes CHEBI:58528."", ""source_locator"": ""http://rdf.rhea-db.org/26519 rh:substrates; corresponding side rh:contains1 / rh:compound / rh:accession""}]"	"[{""id"": ""RHEA:26519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-hydroxypropanoyl-CoA => acryloyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-112_f6fa71898461	RHEA:26519	RO:0002413	RHEA:26456	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456|RHEA:26519	The shared chemical state is CHEBI:57367; this asserts material continuity, not substrate channeling or compulsory kinetic order.	"[{""reference_id"": ""RHEA:26519"", ""source_assertion"": ""Directed reaction 26519 produces CHEBI:57367."", ""source_locator"": ""http://rdf.rhea-db.org/26519 rh:products; corresponding side rh:contains1 / rh:compound / rh:accession""}, {""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Directed reaction 26456 consumes CHEBI:57367."", ""source_locator"": ""http://rdf.rhea-db.org/26456 rh:substrates; corresponding side rh:contains1 / rh:compound / rh:accession""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""acryloyl-CoA + NADPH + H(+) => propanoyl-CoA + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""3-hydroxypropanoyl-CoA => acryloyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-113_1dbb6d7b61ba	RHEA:26456	RO:0002413	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721|RHEA:26456	The shared chemical state is CHEBI:57392; this asserts material continuity, not substrate channeling or compulsory kinetic order.	"[{""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Directed reaction 26456 produces CHEBI:57392."", ""source_locator"": ""http://rdf.rhea-db.org/26456 rh:products; corresponding side rh:contains1 / rh:compound / rh:accession""}, {""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Directed reaction 23721 consumes CHEBI:57392."", ""source_locator"": ""http://rdf.rhea-db.org/23721 rh:substrates; corresponding side rh:contains1 / rh:compound / rh:accession""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""acryloyl-CoA + NADPH + H(+) => propanoyl-CoA + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-114_cf591db9e27f	RHEA:23721	RO:0002413	RHEA:20555	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20555|RHEA:23721	The shared chemical state is CHEBI:57327; this asserts material continuity, not substrate channeling or compulsory kinetic order.	"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Directed reaction 23721 produces CHEBI:57327."", ""source_locator"": ""http://rdf.rhea-db.org/23721 rh:products; corresponding side rh:contains1 / rh:compound / rh:accession""}, {""reference_id"": ""RHEA:20555"", ""source_assertion"": ""Directed reaction 20555 consumes CHEBI:57327."", ""source_locator"": ""http://rdf.rhea-db.org/20555 rh:substrates; corresponding side rh:contains1 / rh:compound / rh:accession""}]"	"[{""id"": ""RHEA:20555"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""(S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-115_5d70788c0d5f	RHEA:20555	RO:0002413	RHEA:22889	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20555|RHEA:22889	The shared chemical state is CHEBI:57326; this asserts material continuity, not substrate channeling or compulsory kinetic order.	"[{""reference_id"": ""RHEA:20555"", ""source_assertion"": ""Directed reaction 20555 produces CHEBI:57326."", ""source_locator"": ""http://rdf.rhea-db.org/20555 rh:products; corresponding side rh:contains1 / rh:compound / rh:accession""}, {""reference_id"": ""RHEA:22889"", ""source_assertion"": ""Directed reaction 22889 consumes CHEBI:57326."", ""source_locator"": ""http://rdf.rhea-db.org/22889 rh:substrates; corresponding side rh:contains1 / rh:compound / rh:accession""}]"	"[{""id"": ""RHEA:20555"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""(S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:22889"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""(R)-methylmalonyl-CoA => succinyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-116_ec93943d2a85	RHEA:22889	RO:0002413	RHEA:38256	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22889|RHEA:38256	The shared chemical state is CHEBI:57292; this asserts material continuity, not substrate channeling or compulsory kinetic order.	"[{""reference_id"": ""RHEA:22889"", ""source_assertion"": ""Directed reaction 22889 produces CHEBI:57292."", ""source_locator"": ""http://rdf.rhea-db.org/22889 rh:products; corresponding side rh:contains1 / rh:compound / rh:accession""}, {""reference_id"": ""RHEA:38256"", ""source_assertion"": ""Directed reaction 38256 consumes CHEBI:57292."", ""source_locator"": ""http://rdf.rhea-db.org/38256 rh:substrates; corresponding side rh:contains1 / rh:compound / rh:accession""}]"	"[{""id"": ""RHEA:22889"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""(R)-methylmalonyl-CoA => succinyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:38256"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""succinyl-CoA + (S)-malate => (S)-malyl-CoA + succinate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-117_9d652773783a	RHEA:38256	RO:0002413	RHEA:40524	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38256|RHEA:40524	The shared chemical state is CHEBI:30031; this asserts material continuity, not substrate channeling or compulsory kinetic order.	"[{""reference_id"": ""RHEA:38256"", ""source_assertion"": ""Directed reaction 38256 produces CHEBI:30031."", ""source_locator"": ""http://rdf.rhea-db.org/38256 rh:products; corresponding side rh:contains1 / rh:compound / rh:accession""}, {""reference_id"": ""RHEA:40524"", ""source_assertion"": ""Directed reaction 40524 consumes CHEBI:30031."", ""source_locator"": ""http://rdf.rhea-db.org/40524 rh:substrates; corresponding side rh:contains1 / rh:compound / rh:accession""}]"	"[{""id"": ""RHEA:38256"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""succinyl-CoA + (S)-malate => (S)-malyl-CoA + succinate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:40524"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""a quinone + succinate => fumarate + a quinol"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-118_990728a4a3b2	RHEA:40524	RO:0002413	RHEA:12462	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12462|RHEA:40524	The shared chemical state is CHEBI:29806; this asserts material continuity, not substrate channeling or compulsory kinetic order.	"[{""reference_id"": ""RHEA:40524"", ""source_assertion"": ""Directed reaction 40524 produces CHEBI:29806."", ""source_locator"": ""http://rdf.rhea-db.org/40524 rh:products; corresponding side rh:contains1 / rh:compound / rh:accession""}, {""reference_id"": ""RHEA:12462"", ""source_assertion"": ""Directed reaction 12462 consumes CHEBI:29806."", ""source_locator"": ""http://rdf.rhea-db.org/12462 rh:substrates; corresponding side rh:contains1 / rh:compound / rh:accession""}]"	"[{""id"": ""RHEA:12462"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""fumarate + H2O => (S)-malate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:40524"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""a quinone + succinate => fumarate + a quinol"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-119_a33720cc74f6	RHEA:12462	RO:0002413	RHEA:38256	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12462|RHEA:38256	The shared chemical state is CHEBI:15589; this asserts material continuity, not substrate channeling or compulsory kinetic order.	"[{""reference_id"": ""RHEA:12462"", ""source_assertion"": ""Directed reaction 12462 produces CHEBI:15589."", ""source_locator"": ""http://rdf.rhea-db.org/12462 rh:products; corresponding side rh:contains1 / rh:compound / rh:accession""}, {""reference_id"": ""RHEA:38256"", ""source_assertion"": ""Directed reaction 38256 consumes CHEBI:15589."", ""source_locator"": ""http://rdf.rhea-db.org/38256 rh:substrates; corresponding side rh:contains1 / rh:compound / rh:accession""}]"	"[{""id"": ""RHEA:12462"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""fumarate + H2O => (S)-malate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:38256"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""succinyl-CoA + (S)-malate => (S)-malyl-CoA + succinate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-120_66f22847e003	RHEA:38256	RO:0002413	RHEA:16630	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16630|RHEA:38256	The shared chemical state is CHEBI:57317; this asserts material continuity, not substrate channeling or compulsory kinetic order.	"[{""reference_id"": ""RHEA:38256"", ""source_assertion"": ""Directed reaction 38256 produces CHEBI:57317."", ""source_locator"": ""http://rdf.rhea-db.org/38256 rh:products; corresponding side rh:contains1 / rh:compound / rh:accession""}, {""reference_id"": ""RHEA:16630"", ""source_assertion"": ""Directed reaction 16630 consumes CHEBI:57317."", ""source_locator"": ""http://rdf.rhea-db.org/16630 rh:substrates; corresponding side rh:contains1 / rh:compound / rh:accession""}]"	"[{""id"": ""RHEA:16630"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""(S)-malyl-CoA => glyoxylate + acetyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:38256"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""succinyl-CoA + (S)-malate => (S)-malyl-CoA + succinate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0043427_threehp-edge-121_0eefe2120f9c	RHEA:16630	RO:0002413	RHEA:54729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16630|RHEA:54729	The shared chemical state is CHEBI:57288; this asserts material continuity, not substrate channeling or compulsory kinetic order.	"[{""reference_id"": ""RHEA:16630"", ""source_assertion"": ""Directed reaction 16630 produces CHEBI:57288."", ""source_locator"": ""http://rdf.rhea-db.org/16630 rh:products; corresponding side rh:contains1 / rh:compound / rh:accession""}, {""reference_id"": ""RHEA:54729"", ""source_assertion"": ""Directed reaction 54729 consumes CHEBI:57288."", ""source_locator"": ""http://rdf.rhea-db.org/54729 rh:substrates; corresponding side rh:contains1 / rh:compound / rh:accession""}]"	"[{""id"": ""RHEA:16630"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""(S)-malyl-CoA => glyoxylate + acetyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:54729"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA256 covers the complete original compressed RDF gzip, not an issuing HTML page"", ""title"": ""N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA => N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-001_17ad8d4fee1e	SGD:S000004506	pathwaymech:enables	gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN RO:0002333 gomodel:YML042W-MONOMER_CARNITINE-O-ACETYLTRANSFERASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/0; endpoint types: /individuals/0/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-002_c7309efc46de	gomodel:YeastPathways_PWY3O-4/6a46ef0600000742	RO:0002233	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000742 RO:0002233 gomodel:YeastPathways_PWY3O-4/6a46ef0600000744."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/1; endpoint types: /individuals/33/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-003_0abd7ccbb981	SGD:S000000080	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4/6a46ef0600000733	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000733 RO:0002333 gomodel:YeastPathways_PWY3O-4/6a46ef0600000739."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/2; endpoint types: /individuals/26/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-004_6e019c962923	gomodel:YeastPathways_PWY3O-4/6a46ef0600000742	RO:0002233	CHEBI:16347	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000742 RO:0002233 gomodel:YeastPathways_PWY3O-4/6a46ef0600000743."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/3; endpoint types: /individuals/33/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-005_7be1e73d4061	gomodel:YeastPathways_PWY3O-4/6a46ef0600000742	RO:0002234	CHEBI:57589	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000742 RO:0002234 gomodel:YeastPathways_PWY3O-4/6a46ef0600000746."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/4; endpoint types: /individuals/33/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-006_0e8c56bc8bff	gomodel:YeastPathways_PWY3O-4/6a46ef0600000742	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000742 RO:0002234 gomodel:YeastPathways_PWY3O-4/6a46ef0600000745."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/5; endpoint types: /individuals/33/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-007_be369b5a3208	gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN	BFO:0000050	GO:0006853	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4/YeastPathways_PWY3O-4."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/6; endpoint types: /individuals/0/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-008_10ac304db2d9	gomodel:RXN3O-37	RO:0002233	CHEBI:57589	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:RXN3O-37 RO:0002233 gomodel:CHEBI_57589_RXN3O-37."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/7; endpoint types: /individuals/9/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-009_84b814903036	gomodel:YeastPathways_PWY3O-4/6a46ef0600000742	BFO:0000050	GO:0006853	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000742 BFO:0000050 gomodel:YeastPathways_PWY3O-4/YeastPathways_PWY3O-4."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/8; endpoint types: /individuals/33/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-010_d329a444984a	gomodel:YeastPathways_PWY3O-4/6a46ef0600000733	RO:0002233	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000733 RO:0002233 gomodel:YeastPathways_PWY3O-4/6a46ef0600000735."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/9; endpoint types: /individuals/26/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-011_ee6c4ad7a6ea	SGD:S000000826	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4/6a46ef0600000742	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000742 RO:0002333 gomodel:YeastPathways_PWY3O-4/6a46ef0600000749."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/10; endpoint types: /individuals/33/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-013_32f0abb5215e	gomodel:YeastPathways_PWY3O-4/6a46ef0600000733	RO:0002234	CHEBI:57589	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000733 RO:0002234 gomodel:YeastPathways_PWY3O-4/6a46ef0600000737."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/12; endpoint types: /individuals/26/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-014_dd36edb08431	gomodel:YeastPathways_PWY3O-4/6a46ef0600000733	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000733 RO:0002234 gomodel:YeastPathways_PWY3O-4/6a46ef0600000736."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/13; endpoint types: /individuals/26/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-015_243db99fef1a	gomodel:RXN3O-37	BFO:0000050	GO:0006853	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:RXN3O-37 BFO:0000050 gomodel:YeastPathways_PWY3O-4/YeastPathways_PWY3O-4."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/14; endpoint types: /individuals/9/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-016_c36c4a4f8788	gomodel:YeastPathways_PWY3O-4/6a46ef0600000733	BFO:0000050	GO:0006853	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000733 BFO:0000050 gomodel:YeastPathways_PWY3O-4/YeastPathways_PWY3O-4."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/15; endpoint types: /individuals/26/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-017_759c8f4795cb	gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_57287_CARNITINE-O-ACETYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/16; endpoint types: /individuals/0/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-018_90027e01ef32	gomodel:YeastPathways_PWY3O-4/6a46ef0600000733	RO:0002411	gomodel:RXN3O-37	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000733 RO:0002411 gomodel:RXN3O-37."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/17; endpoint types: /individuals/26/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-019_af62b0f0e14b	gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN	RO:0002234	CHEBI:57589	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_57589_CARNITINE-O-ACETYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/18; endpoint types: /individuals/0/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-020_18782f1b3a62	gomodel:RXN3O-37	RO:0002234	CHEBI:16347	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:RXN3O-37 RO:0002234 gomodel:CHEBI_16347_RXN3O-37."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/19; endpoint types: /individuals/9/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-021_12c137416c80	gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN	RO:0002233	CHEBI:16347	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_16347_CARNITINE-O-ACETYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/20; endpoint types: /individuals/0/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-022_f3917dd0b497	gomodel:YeastPathways_PWY3O-4/6a46ef0600000733	RO:0002233	CHEBI:16347	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000733 RO:0002233 gomodel:YeastPathways_PWY3O-4/6a46ef0600000734."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/21; endpoint types: /individuals/26/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-023_208d48d5aa09	gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN	RO:0002233	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_57288_CARNITINE-O-ACETYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/22; endpoint types: /individuals/0/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-024_d2366ac5b050	SGD:S000004506	pathwaymech:enables	gomodel:RXN3O-37	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:RXN3O-37 RO:0002333 gomodel:YML042W-MONOMER_RXN3O-37_controller."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/23; endpoint types: /individuals/9/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-026_6ea91766f72b	gomodel:YeastPathways_PWY3O-4/6a46ef0600000742	RO:0002411	gomodel:RXN3O-37	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000742 RO:0002411 gomodel:RXN3O-37."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/25; endpoint types: /individuals/33/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-027_ce04a85cb941	gomodel:RXN3O-37	RO:0002234	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:RXN3O-37 RO:0002234 gomodel:CHEBI_57288_RXN3O-37."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/26; endpoint types: /individuals/9/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-028_6255f8ce1cfc	gomodel:YeastPathways_PWY3O-4/6a46ef0600000742	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000742 BFO:0000066 gomodel:YeastPathways_PWY3O-4/6a46ef0600000750."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/27; endpoint types: /individuals/33/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-029_96fd2a941437	gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN	RO:0002411	gomodel:RXN3O-37	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN RO:0002411 gomodel:RXN3O-37."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/28; endpoint types: /individuals/0/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_edge-030_3f9b699ccde8	gomodel:RXN3O-37	RO:0002233	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_assertion"": ""The model asserts gomodel:RXN3O-37 RO:0002233 gomodel:CHEBI_57287_RXN3O-37."", ""source_locator"": ""./YeastPathways_PWY3O-4.json#/facts/29; endpoint types: /individuals/9/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json"", ""title"": ""SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_location-059db5a07874_c45292e97e29	SGD:S000004506	RO:0001025	GO:0005743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32796	Physical protein location from reviewed UniProt. evidence code not specified by source; molecular form: Isoform Mitochondrial. Topology: Peripheral membrane protein. Orientation: Matrix side.	"[{""reference_id"": ""UniProtKB:P32796"", ""source_assertion"": ""UniProtKB:P32796 annotates location Mitochondrion inner membrane (SL-0168); molecular form: Isoform Mitochondrial."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1002/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32796"", ""source_assertion"": ""UniProtKB:P32796 has the exact SGD cross-reference SGD:S000004506."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1002/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32796"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32796 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_location-04748433cb18_a9112b13a751	SGD:S000004506	RO:0001025	GO:0005777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32796	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:7628448); molecular form: Isoform Peroxisomal.	"[{""reference_id"": ""UniProtKB:P32796"", ""source_assertion"": ""UniProtKB:P32796 annotates location Peroxisome (SL-0204); molecular form: Isoform Peroxisomal."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1002/comments/2/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32796"", ""source_assertion"": ""UniProtKB:P32796 has the exact SGD cross-reference SGD:S000004506."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1002/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32796"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32796 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_location-302dac6a15dc_075916e0a184	SGD:S000000080	RO:0001025	GO:0005743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P80235	Physical protein location from reviewed UniProt. evidence code not specified by source Topology: Peripheral membrane protein. Orientation: Intermembrane side.	"[{""reference_id"": ""UniProtKB:P80235"", ""source_assertion"": ""UniProtKB:P80235 annotates location Mitochondrion inner membrane (SL-0168)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4032/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P80235"", ""source_assertion"": ""UniProtKB:P80235 has the exact SGD cross-reference SGD:S000000080."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4032/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P80235"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P80235 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4_location-d83c0d11c76d_86ec522349d9	SGD:S000000826	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40017	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:18427809)	"[{""reference_id"": ""UniProtKB:P40017"", ""source_assertion"": ""UniProtKB:P40017 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3704/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P40017"", ""source_assertion"": ""UniProtKB:P40017 has the exact SGD cross-reference SGD:S000000826."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3704/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40017"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40017 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-001_54a7c228ce36	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871	RO:0002234	CHEBI:17029	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871 RO:0002234 gomodel:CHEBI_17029_CHITIN-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/0; endpoint types: /individuals/13/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-002_be5ac0593d8f	gomodel:CHITIN-SYNTHASE-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:CHITIN-SYNTHASE-RXN RO:0002413 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/1; endpoint types: /individuals/3/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-003_d374a87f49d0	SGD:S000000227	pathwaymech:enables	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891 RO:0002333 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000895."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/2; endpoint types: /individuals/25/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-004_f0c06977d256	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891	RO:0002234	CHEBI:17029	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891 RO:0002234 gomodel:CHEBI_17029_CHITIN-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/3; endpoint types: /individuals/25/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-005_a1726c96476c	SGD:S000005136	pathwaymech:enables	gomodel:CHITIN-SYNTHASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:CHITIN-SYNTHASE-RXN RO:0002333 gomodel:YNL192W-MONOMER_CHITIN-SYNTHASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/4; endpoint types: /individuals/3/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-006_c1f7c7d63d64	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871	RO:0002413	gomodel:CHITIN-SYNTHASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871 RO:0002413 gomodel:CHITIN-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/5; endpoint types: /individuals/13/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-008_f6e42db6d06b	gomodel:CHITIN-SYNTHASE-RXN	RO:0002234	CHEBI:58223	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:CHITIN-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_58223_CHITIN-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/7; endpoint types: /individuals/3/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-009_1a1d0635f24e	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871	RO:0002413	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871 RO:0002413 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/8; endpoint types: /individuals/13/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-010_db20c651f8a9	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891	BFO:0000050	GO:0006031	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891 BFO:0000050 gomodel:YeastPathways_PWY3O-15/YeastPathways_PWY3O-15."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/9; endpoint types: /individuals/25/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-012_a7aeb6f59aae	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871	RO:0002233	CHEBI:17029	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871 RO:0002233 gomodel:CHEBI_17029_CHITIN-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/11; endpoint types: /individuals/13/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-013_666d72c32f53	gomodel:CHITIN-SYNTHASE-RXN	RO:0002234	CHEBI:17029	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:CHITIN-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_17029_CHITIN-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/12; endpoint types: /individuals/3/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-014_cf4a632cfeed	gomodel:CHITIN-SYNTHASE-RXN	RO:0002233	CHEBI:57705	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:CHITIN-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_57705_CHITIN-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/13; endpoint types: /individuals/3/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-015_ca66d9018b41	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891	RO:0002234	CHEBI:58223	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891 RO:0002234 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000893."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/14; endpoint types: /individuals/25/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-016_0f767c056c5a	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891	RO:0002233	CHEBI:17029	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891 RO:0002233 gomodel:CHEBI_17029_CHITIN-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/15; endpoint types: /individuals/25/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-017_db98991c896e	gomodel:CHITIN-SYNTHASE-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:CHITIN-SYNTHASE-RXN RO:0002413 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/16; endpoint types: /individuals/3/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-018_b86917fe4bfa	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891	RO:0002413	gomodel:CHITIN-SYNTHASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891 RO:0002413 gomodel:CHITIN-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/17; endpoint types: /individuals/25/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-019_fedec8ceabdf	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871	RO:0002233	CHEBI:57705	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871 RO:0002233 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000872."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/18; endpoint types: /individuals/13/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-020_b0757e93e1ba	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871	RO:0002234	CHEBI:58223	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871 RO:0002234 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000873."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/19; endpoint types: /individuals/13/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-021_39ade8838035	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871	BFO:0000050	GO:0006031	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871 BFO:0000050 gomodel:YeastPathways_PWY3O-15/YeastPathways_PWY3O-15."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/20; endpoint types: /individuals/13/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-023_fc0821c13307	gomodel:CHITIN-SYNTHASE-RXN	BFO:0000050	GO:0006031	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:CHITIN-SYNTHASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-15/YeastPathways_PWY3O-15."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/22; endpoint types: /individuals/3/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-024_7b8552f7cd06	gomodel:CHITIN-SYNTHASE-RXN	RO:0002233	CHEBI:17029	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:CHITIN-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_17029_CHITIN-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/23; endpoint types: /individuals/3/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-025_f96cf8d8d06f	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891	RO:0002413	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891 RO:0002413 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/24; endpoint types: /individuals/25/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-026_9af17e548ae9	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891	RO:0002233	CHEBI:57705	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891 RO:0002233 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000892."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/25; endpoint types: /individuals/25/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_edge-027_892f2fa5d209	SGD:S000000242	pathwaymech:enables	gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-15		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871 RO:0002333 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000875."", ""source_locator"": ""./YeastPathways_PWY3O-15.json#/facts/26; endpoint types: /individuals/13/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-15"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json"", ""title"": ""SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_location-09b55052003b_a3a0e4a566e7	SGD:S000000227	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P29465	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12928491); ECO:0000269 (PubMed:17519287); ECO:0000269 (PubMed:28346351) Topology: Multi-pass membrane protein. Source qualification: Localizes to a ring on the surface of cells about to undergo bud emergence and in the mother-bud neck of small-budded cells (PubMed:8909536). Delocalized throughout the plasma membrane during heat shock (PubMed:12928491). Also localizes to intracellular membrane-bound particles called chitosomes, proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum (PubMed:12928491, PubMed:8970154)	"[{""reference_id"": ""UniProtKB:P29465"", ""source_assertion"": ""UniProtKB:P29465 annotates location Cell membrane (SL-0039)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/813/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P29465"", ""source_assertion"": ""UniProtKB:P29465 has the exact SGD cross-reference SGD:S000000227."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/813/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P29465"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P29465 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_location-dc30851a464c_9e1e4a1a2e97	SGD:S000000227	RO:0001025	GO:0005935	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P29465	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16818716); ECO:0000269 (PubMed:28346351); ECO:0000269 (PubMed:8909536) Source qualification: Localizes to a ring on the surface of cells about to undergo bud emergence and in the mother-bud neck of small-budded cells (PubMed:8909536). Delocalized throughout the plasma membrane during heat shock (PubMed:12928491). Also localizes to intracellular membrane-bound particles called chitosomes, proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum (PubMed:12928491, PubMed:8970154)	"[{""reference_id"": ""UniProtKB:P29465"", ""source_assertion"": ""UniProtKB:P29465 annotates location Bud neck (SL-0029)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/813/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P29465"", ""source_assertion"": ""UniProtKB:P29465 has the exact SGD cross-reference SGD:S000000227."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/813/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P29465"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P29465 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_location-7d68436137f0_1fa6b771d418	SGD:S000000227	RO:0001025	GO:0030659	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P29465	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12928491); ECO:0000269 (PubMed:28346351); ECO:0000269 (PubMed:8970154) Topology: Multi-pass membrane protein. Source qualification: Localizes to a ring on the surface of cells about to undergo bud emergence and in the mother-bud neck of small-budded cells (PubMed:8909536). Delocalized throughout the plasma membrane during heat shock (PubMed:12928491). Also localizes to intracellular membrane-bound particles called chitosomes, proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum (PubMed:12928491, PubMed:8970154)	"[{""reference_id"": ""UniProtKB:P29465"", ""source_assertion"": ""UniProtKB:P29465 annotates location Cytoplasmic vesicle membrane (SL-0089)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/813/comments/1/subcellularLocations/2; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P29465"", ""source_assertion"": ""UniProtKB:P29465 has the exact SGD cross-reference SGD:S000000227."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/813/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P29465"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P29465 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_location-a8997d14f8f7_4fd95be19daa	SGD:S000005136	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08004	Physical protein location from reviewed UniProt. ECO:0000305 (PubMed:2523889) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P08004"", ""source_assertion"": ""UniProtKB:P08004 annotates location Cell membrane (SL-0039)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/198/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P08004"", ""source_assertion"": ""UniProtKB:P08004 has the exact SGD cross-reference SGD:S000005136."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/198/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P08004"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P08004 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-15_location-b973f60d71be_9879e8dfb1e9	SGD:S000000242	RO:0001025	GO:0016020	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P14180	Physical protein location from reviewed UniProt. ECO:0000305 Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P14180"", ""source_assertion"": ""UniProtKB:P14180 annotates location Membrane (SL-0162)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/382/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P14180"", ""source_assertion"": ""UniProtKB:P14180 has the exact SGD cross-reference SGD:S000000242."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/382/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P14180"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P14180 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-001_3aa056225a9c	CHEBI:15377	pathwaymech:consumes	RHEA:14718	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14718		"[{""reference_id"": ""RHEA:14718"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:14718 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14718']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14718"", ""source_version"": ""139"", ""title"": ""Rhea 3-deoxy-D-arabino-heptulosonate 7-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14718""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-002_a5913d8488d0	CHEBI:16897	pathwaymech:consumes	RHEA:14718	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14718		"[{""reference_id"": ""RHEA:14718"", ""source_assertion"": ""Rhea lists CHEBI:16897 on the substrates side of RHEA:14718 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14718']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14718"", ""source_version"": ""139"", ""title"": ""Rhea 3-deoxy-D-arabino-heptulosonate 7-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14718""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-003_60832e7f80ea	CHEBI:58702	pathwaymech:consumes	RHEA:14718	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14718		"[{""reference_id"": ""RHEA:14718"", ""source_assertion"": ""Rhea lists CHEBI:58702 on the substrates side of RHEA:14718 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14718']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14718"", ""source_version"": ""139"", ""title"": ""Rhea 3-deoxy-D-arabino-heptulosonate 7-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14718""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-004_37f3a5eba09c	RHEA:14718	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14718		"[{""reference_id"": ""RHEA:14718"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:14718 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14718']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14718"", ""source_version"": ""139"", ""title"": ""Rhea 3-deoxy-D-arabino-heptulosonate 7-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14718""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-005_6f7ad84d3884	RHEA:14718	pathwaymech:produces	CHEBI:58394	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14718		"[{""reference_id"": ""RHEA:14718"", ""source_assertion"": ""Rhea lists CHEBI:58394 on the products side of RHEA:14718 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14718']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14718"", ""source_version"": ""139"", ""title"": ""Rhea 3-deoxy-D-arabino-heptulosonate 7-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14718""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-006_d045513ad818	CHEBI:58394	pathwaymech:consumes	RHEA:21969	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21969		"[{""reference_id"": ""RHEA:21969"", ""source_assertion"": ""Rhea lists CHEBI:58394 on the substrates side of RHEA:21969 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21969']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21969"", ""source_version"": ""139"", ""title"": ""Rhea 3-dehydroquinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21969""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-007_7e7a85ee041d	RHEA:21969	pathwaymech:produces	CHEBI:32364	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21969		"[{""reference_id"": ""RHEA:21969"", ""source_assertion"": ""Rhea lists CHEBI:32364 on the products side of RHEA:21969 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21969']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21969"", ""source_version"": ""139"", ""title"": ""Rhea 3-dehydroquinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21969""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-008_16fd1316947a	RHEA:21969	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21969		"[{""reference_id"": ""RHEA:21969"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:21969 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21969']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21969"", ""source_version"": ""139"", ""title"": ""Rhea 3-dehydroquinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21969""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-009_499b0f0a8861	CHEBI:32364	pathwaymech:consumes	RHEA:21097	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21097		"[{""reference_id"": ""RHEA:21097"", ""source_assertion"": ""Rhea lists CHEBI:32364 on the substrates side of RHEA:21097 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21097']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21097"", ""source_version"": ""139"", ""title"": ""Rhea 3-dehydroshikimate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21097""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-010_ac029952fad5	RHEA:21097	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21097		"[{""reference_id"": ""RHEA:21097"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:21097 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21097']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21097"", ""source_version"": ""139"", ""title"": ""Rhea 3-dehydroshikimate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21097""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-011_5ce7945ca135	RHEA:21097	pathwaymech:produces	CHEBI:16630	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21097		"[{""reference_id"": ""RHEA:21097"", ""source_assertion"": ""Rhea lists CHEBI:16630 on the products side of RHEA:21097 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21097']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21097"", ""source_version"": ""139"", ""title"": ""Rhea 3-dehydroshikimate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21097""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-012_027af3ce46a8	CHEBI:15378	pathwaymech:consumes	RHEA:17739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17739		"[{""reference_id"": ""RHEA:17739"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:17739 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17739']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17739"", ""source_version"": ""139"", ""title"": ""Rhea shikimate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17739""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-013_b853a1dc0691	CHEBI:16630	pathwaymech:consumes	RHEA:17739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17739		"[{""reference_id"": ""RHEA:17739"", ""source_assertion"": ""Rhea lists CHEBI:16630 on the substrates side of RHEA:17739 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17739']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17739"", ""source_version"": ""139"", ""title"": ""Rhea shikimate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17739""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-014_3b251582f75c	CHEBI:57783	pathwaymech:consumes	RHEA:17739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17739		"[{""reference_id"": ""RHEA:17739"", ""source_assertion"": ""Rhea lists CHEBI:57783 on the substrates side of RHEA:17739 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17739']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17739"", ""source_version"": ""139"", ""title"": ""Rhea shikimate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17739""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-015_0341dfb759ce	RHEA:17739	pathwaymech:produces	CHEBI:36208	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17739		"[{""reference_id"": ""RHEA:17739"", ""source_assertion"": ""Rhea lists CHEBI:36208 on the products side of RHEA:17739 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17739']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17739"", ""source_version"": ""139"", ""title"": ""Rhea shikimate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17739""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-016_84c2615527f6	RHEA:17739	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17739		"[{""reference_id"": ""RHEA:17739"", ""source_assertion"": ""Rhea lists CHEBI:58349 on the products side of RHEA:17739 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17739']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17739"", ""source_version"": ""139"", ""title"": ""Rhea shikimate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17739""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-017_3bb4dfff4234	CHEBI:30616	pathwaymech:consumes	RHEA:13122	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13122		"[{""reference_id"": ""RHEA:13122"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:13122 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13122']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13122"", ""source_version"": ""139"", ""title"": ""Rhea 3-phosphoshikimate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/13122""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-018_bfa7e4a225ac	CHEBI:36208	pathwaymech:consumes	RHEA:13122	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13122		"[{""reference_id"": ""RHEA:13122"", ""source_assertion"": ""Rhea lists CHEBI:36208 on the substrates side of RHEA:13122 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13122']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13122"", ""source_version"": ""139"", ""title"": ""Rhea 3-phosphoshikimate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/13122""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-019_0540d8d582c5	RHEA:13122	pathwaymech:produces	CHEBI:145989	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13122		"[{""reference_id"": ""RHEA:13122"", ""source_assertion"": ""Rhea lists CHEBI:145989 on the products side of RHEA:13122 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13122']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13122"", ""source_version"": ""139"", ""title"": ""Rhea 3-phosphoshikimate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/13122""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-020_97434749ba6f	RHEA:13122	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13122		"[{""reference_id"": ""RHEA:13122"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:13122 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13122']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13122"", ""source_version"": ""139"", ""title"": ""Rhea 3-phosphoshikimate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/13122""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-021_86cd01554dfb	RHEA:13122	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13122		"[{""reference_id"": ""RHEA:13122"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:13122 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13122']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13122"", ""source_version"": ""139"", ""title"": ""Rhea 3-phosphoshikimate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/13122""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-022_f425fbb0314e	CHEBI:145989	pathwaymech:consumes	RHEA:21257	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21257		"[{""reference_id"": ""RHEA:21257"", ""source_assertion"": ""Rhea lists CHEBI:145989 on the substrates side of RHEA:21257 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21257']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21257"", ""source_version"": ""139"", ""title"": ""Rhea 5-O-(1-carboxyvinyl)-3-phosphoshikimate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21257""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-023_b7bffabc696e	CHEBI:58702	pathwaymech:consumes	RHEA:21257	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21257		"[{""reference_id"": ""RHEA:21257"", ""source_assertion"": ""Rhea lists CHEBI:58702 on the substrates side of RHEA:21257 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21257']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21257"", ""source_version"": ""139"", ""title"": ""Rhea 5-O-(1-carboxyvinyl)-3-phosphoshikimate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21257""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-024_8436dab959ab	RHEA:21257	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21257		"[{""reference_id"": ""RHEA:21257"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:21257 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21257']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21257"", ""source_version"": ""139"", ""title"": ""Rhea 5-O-(1-carboxyvinyl)-3-phosphoshikimate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21257""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-025_077adcc7a993	RHEA:21257	pathwaymech:produces	CHEBI:57701	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21257		"[{""reference_id"": ""RHEA:21257"", ""source_assertion"": ""Rhea lists CHEBI:57701 on the products side of RHEA:21257 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21257']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21257"", ""source_version"": ""139"", ""title"": ""Rhea 5-O-(1-carboxyvinyl)-3-phosphoshikimate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21257""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-026_8d25992d2700	CHEBI:57701	pathwaymech:consumes	RHEA:21021	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21021		"[{""reference_id"": ""RHEA:21021"", ""source_assertion"": ""Rhea lists CHEBI:57701 on the substrates side of RHEA:21021 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21021']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21021"", ""source_version"": ""139"", ""title"": ""Rhea chorismate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21021""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-027_ca21c50efe01	RHEA:21021	pathwaymech:produces	CHEBI:29748	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21021		"[{""reference_id"": ""RHEA:21021"", ""source_assertion"": ""Rhea lists CHEBI:29748 on the products side of RHEA:21021 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21021']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21021"", ""source_version"": ""139"", ""title"": ""Rhea chorismate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21021""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-028_6c470cf7302f	RHEA:21021	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21021		"[{""reference_id"": ""RHEA:21021"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:21021 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21021']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21021"", ""source_version"": ""139"", ""title"": ""Rhea chorismate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21021""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-029_5eb1d3d0a7a3	EC:2.5.1.54	pathwaymech:catalyzes	RHEA:14718	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14717		"[{""reference_id"": ""RHEA:14717"", ""source_assertion"": ""Rhea associates EC:2.5.1.54 with the reaction family containing RHEA:14718."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:14717"", ""source_version"": ""139"", ""title"": ""Rhea 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/14717""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-030_629d144b6db2	EC:4.2.3.4	pathwaymech:catalyzes	RHEA:21969	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21968		"[{""reference_id"": ""RHEA:21968"", ""source_assertion"": ""Rhea associates EC:4.2.3.4 with the reaction family containing RHEA:21969."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:21968"", ""source_version"": ""139"", ""title"": ""Rhea 3-dehydroquinate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/21968""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-031_4e0aef3f5590	EC:4.2.1.10	pathwaymech:catalyzes	RHEA:21097	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21096		"[{""reference_id"": ""RHEA:21096"", ""source_assertion"": ""Rhea associates EC:4.2.1.10 with the reaction family containing RHEA:21097."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:21096"", ""source_version"": ""139"", ""title"": ""Rhea 3-dehydroquinate dehydratase reaction"", ""url"": ""https://www.rhea-db.org/rhea/21096""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-032_fa2420ba8b38	EC:1.1.1.25	pathwaymech:catalyzes	RHEA:17739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17737		"[{""reference_id"": ""RHEA:17737"", ""source_assertion"": ""Rhea associates EC:1.1.1.25 with the reaction family containing RHEA:17739."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:17737"", ""source_version"": ""139"", ""title"": ""Rhea shikimate dehydrogenase reaction"", ""url"": ""https://www.rhea-db.org/rhea/17737""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-033_228baf582bab	EC:2.7.1.71	pathwaymech:catalyzes	RHEA:13122	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13121		"[{""reference_id"": ""RHEA:13121"", ""source_assertion"": ""Rhea associates EC:2.7.1.71 with the reaction family containing RHEA:13122."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:13121"", ""source_version"": ""139"", ""title"": ""Rhea shikimate kinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/13121""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-034_6ff96813ba04	EC:2.5.1.19	pathwaymech:catalyzes	RHEA:21257	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21256		"[{""reference_id"": ""RHEA:21256"", ""source_assertion"": ""Rhea associates EC:2.5.1.19 with the reaction family containing RHEA:21257."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:21256"", ""source_version"": ""139"", ""title"": ""Rhea 3-phosphoshikimate 1-carboxyvinyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/21256""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-035_4816946c23d5	EC:4.2.3.5	pathwaymech:catalyzes	RHEA:21021	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21020		"[{""reference_id"": ""RHEA:21020"", ""source_assertion"": ""Rhea associates EC:4.2.3.5 with the reaction family containing RHEA:21021."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:21020"", ""source_version"": ""139"", ""title"": ""Rhea chorismate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/21020""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-036_fb02437d553c	RHEA:13122	pathwaymech:precedes	RHEA:21257	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARO-PWY		"[{""reference_id"": ""MetaCyc:ARO-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:13122 before RHEA:21257 in this pathway. Shared intermediate: CHEBI:145989."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARO-PWY"", ""source_sha256"": ""d66a329b9eca61223023c9c791e28c9399ea72f44775f292befd01965d97c058"", ""source_version"": ""22.5"", ""title"": ""MetaCyc chorismate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARO-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-037_c6ed78445e5c	RHEA:14718	pathwaymech:precedes	RHEA:21969	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARO-PWY		"[{""reference_id"": ""MetaCyc:ARO-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:14718 before RHEA:21969 in this pathway. Shared intermediate: CHEBI:58394."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARO-PWY"", ""source_sha256"": ""d66a329b9eca61223023c9c791e28c9399ea72f44775f292befd01965d97c058"", ""source_version"": ""22.5"", ""title"": ""MetaCyc chorismate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARO-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-038_a773b61f4dd8	RHEA:17739	pathwaymech:precedes	RHEA:13122	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARO-PWY		"[{""reference_id"": ""MetaCyc:ARO-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:17739 before RHEA:13122 in this pathway. Shared intermediate: CHEBI:36208."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARO-PWY"", ""source_sha256"": ""d66a329b9eca61223023c9c791e28c9399ea72f44775f292befd01965d97c058"", ""source_version"": ""22.5"", ""title"": ""MetaCyc chorismate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARO-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-039_bbdfb611a325	RHEA:21097	pathwaymech:precedes	RHEA:17739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARO-PWY		"[{""reference_id"": ""MetaCyc:ARO-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:21097 before RHEA:17739 in this pathway. Shared intermediate: CHEBI:16630."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARO-PWY"", ""source_sha256"": ""d66a329b9eca61223023c9c791e28c9399ea72f44775f292befd01965d97c058"", ""source_version"": ""22.5"", ""title"": ""MetaCyc chorismate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARO-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-040_0aa02dde8ec4	RHEA:21257	pathwaymech:precedes	RHEA:21021	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARO-PWY		"[{""reference_id"": ""MetaCyc:ARO-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:21257 before RHEA:21021 in this pathway. Shared intermediate: CHEBI:57701."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARO-PWY"", ""source_sha256"": ""d66a329b9eca61223023c9c791e28c9399ea72f44775f292befd01965d97c058"", ""source_version"": ""22.5"", ""title"": ""MetaCyc chorismate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARO-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-041_9d40fb104fbb	RHEA:21969	pathwaymech:precedes	RHEA:21097	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARO-PWY		"[{""reference_id"": ""MetaCyc:ARO-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:21969 before RHEA:21097 in this pathway. Shared intermediate: CHEBI:32364."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARO-PWY"", ""source_sha256"": ""d66a329b9eca61223023c9c791e28c9399ea72f44775f292befd01965d97c058"", ""source_version"": ""22.5"", ""title"": ""MetaCyc chorismate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARO-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-042_1c2b3a360d7f	UniProtKB:P00887	pathwaymech:enables	RHEA:14718	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00887		"[{""reference_id"": ""UniProtKB:P00887"", ""source_assertion"": ""UniProt annotates UniProtKB:P00887 with catalytic activity for the reaction family of RHEA:14718. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00887"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00887 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00887.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-043_4be64312bb19	UniProtKB:P00887	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00887		"[{""reference_id"": ""UniProtKB:P00887"", ""source_assertion"": ""UniProt locates UniProtKB:P00887 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P00887"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00887 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00887.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-044_87a828786c84	UniProtKB:P00888	pathwaymech:enables	RHEA:14718	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00888		"[{""reference_id"": ""UniProtKB:P00888"", ""source_assertion"": ""UniProt annotates UniProtKB:P00888 with catalytic activity for the reaction family of RHEA:14718. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00888"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00888 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00888.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-045_450ac9735170	CHEBI:58315	pathwaymech:inhibits	UniProtKB:P00888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00888		"[{""reference_id"": ""UniProtKB:P00888"", ""source_assertion"": ""UniProt activity-regulation annotation: Specifically feedback inhibited by tyrosine with 50% inhibition observed at 9 microM tyrosine, pH 7.0"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P00888"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00888 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00888.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-046_693dbc94d156	UniProtKB:P00888	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00888		"[{""reference_id"": ""UniProtKB:P00888"", ""source_assertion"": ""UniProt locates UniProtKB:P00888 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P00888"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00888 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00888.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-047_fa64519466be	UniProtKB:P00888	pathwaymech:has_cofactor	CHEBI:60240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00888		"[{""reference_id"": ""UniProtKB:P00888"", ""source_assertion"": ""UniProt lists CHEBI:60240 as a cofactor of UniProtKB:P00888 (evidence: curated annotation). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P00888"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00888 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00888.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-048_42eff4475b92	UniProtKB:P05194	pathwaymech:enables	RHEA:21097	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05194		"[{""reference_id"": ""UniProtKB:P05194"", ""source_assertion"": ""UniProt annotates UniProtKB:P05194 with catalytic activity for the reaction family of RHEA:21097. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P05194"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05194 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05194.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-049_75973437bf99	UniProtKB:P07639	pathwaymech:enables	RHEA:21969	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07639		"[{""reference_id"": ""UniProtKB:P07639"", ""source_assertion"": ""UniProt annotates UniProtKB:P07639 with catalytic activity for the reaction family of RHEA:21969. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P07639"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P07639 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07639.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-050_72a39de2b922	UniProtKB:P07639	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07639		"[{""reference_id"": ""UniProtKB:P07639"", ""source_assertion"": ""UniProt locates UniProtKB:P07639 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P07639"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P07639 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07639.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-051_7db8b88644d7	UniProtKB:P07639	pathwaymech:has_cofactor	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07639		"[{""reference_id"": ""UniProtKB:P07639"", ""source_assertion"": ""UniProt lists CHEBI:57540 as a cofactor of UniProtKB:P07639 (evidence: ECO:0000255, ECO:0000269). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P07639"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P07639 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07639.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-052_8a97d797fd83	UniProtKB:P07639	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07639		"[{""reference_id"": ""UniProtKB:P07639"", ""source_assertion"": ""UniProt lists CHEBI:48828 as a cofactor of UniProtKB:P07639 (evidence: ECO:0000255, ECO:0000269). Binds 1 divalent metal cation per subunit. Displays higher activity with Co(2+), however, Zn(2+) may be the physiological metal cofactor."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P07639"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P07639 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07639.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-053_23046136dc28	UniProtKB:P07639	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07639		"[{""reference_id"": ""UniProtKB:P07639"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P07639 (evidence: ECO:0000255, ECO:0000269). Binds 1 divalent metal cation per subunit. Displays higher activity with Co(2+), however, Zn(2+) may be the physiological metal cofactor."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P07639"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P07639 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07639.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-054_7648bff6ba6b	UniProtKB:P0A6D3	pathwaymech:enables	RHEA:21257	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6D3		"[{""reference_id"": ""UniProtKB:P0A6D3"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A6D3 with catalytic activity for the reaction family of RHEA:21257. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A6D3"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6D3 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6D3.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-055_a855c649c6e8	UniProtKB:P0A6D3	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6D3		"[{""reference_id"": ""UniProtKB:P0A6D3"", ""source_assertion"": ""UniProt locates UniProtKB:P0A6D3 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255, ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A6D3"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6D3 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6D3.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-056_8f93b0ae448b	UniProtKB:P0A6D7	pathwaymech:enables	RHEA:13122	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6D7		"[{""reference_id"": ""UniProtKB:P0A6D7"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A6D7 with catalytic activity for the reaction family of RHEA:13122. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A6D7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6D7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6D7.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-057_76b6c868c811	UniProtKB:P0A6D7	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6D7		"[{""reference_id"": ""UniProtKB:P0A6D7"", ""source_assertion"": ""UniProt locates UniProtKB:P0A6D7 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A6D7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6D7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6D7.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-058_55e430577986	UniProtKB:P0A6D7	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6D7		"[{""reference_id"": ""UniProtKB:P0A6D7"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P0A6D7 (evidence: ECO:0000305). Binds 1 Mg(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0A6D7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6D7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6D7.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-059_a320ee42fd77	UniProtKB:P0A6E1	pathwaymech:enables	RHEA:13122	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6E1		"[{""reference_id"": ""UniProtKB:P0A6E1"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A6E1 with catalytic activity for the reaction family of RHEA:13122. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A6E1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6E1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6E1.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-060_bb990e5bb189	UniProtKB:P0A6E1	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6E1		"[{""reference_id"": ""UniProtKB:P0A6E1"", ""source_assertion"": ""UniProt locates UniProtKB:P0A6E1 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000250."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A6E1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6E1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6E1.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-061_e709d997e585	UniProtKB:P0A6E1	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6E1		"[{""reference_id"": ""UniProtKB:P0A6E1"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P0A6E1 (evidence: ECO:0000269). Binds 1 Mg(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0A6E1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6E1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6E1.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-062_df233ad213f7	UniProtKB:P0AB91	pathwaymech:enables	RHEA:14718	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AB91		"[{""reference_id"": ""UniProtKB:P0AB91"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AB91 with catalytic activity for the reaction family of RHEA:14718. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AB91"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AB91 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AB91.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-063_f1f15ad3972b	UniProtKB:P0AB91	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AB91		"[{""reference_id"": ""UniProtKB:P0AB91"", ""source_assertion"": ""UniProt locates UniProtKB:P0AB91 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0AB91"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AB91 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AB91.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-064_ef28cc646440	UniProtKB:P12008	pathwaymech:enables	RHEA:21021	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P12008		"[{""reference_id"": ""UniProtKB:P12008"", ""source_assertion"": ""UniProt annotates UniProtKB:P12008 with catalytic activity for the reaction family of RHEA:21021. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P12008"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P12008 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P12008.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-065_177140ba2d3f	UniProtKB:P12008	pathwaymech:has_cofactor	CHEBI:57618	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P12008		"[{""reference_id"": ""UniProtKB:P12008"", ""source_assertion"": ""UniProt lists CHEBI:57618 as a cofactor of UniProtKB:P12008 (evidence: ECO:0000255, ECO:0000269). Reduced FMN (FMNH(2)). It can also use FAD, however FMN is the preferred cofactor."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P12008"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P12008 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P12008.json""}]"	""
pathwaymech:MetaCyc_ARO-PWY_edge-066_7dd086e3be09	UniProtKB:P15770	pathwaymech:enables	RHEA:17739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15770		"[{""reference_id"": ""UniProtKB:P15770"", ""source_assertion"": ""UniProt annotates UniProtKB:P15770 with catalytic activity for the reaction family of RHEA:17739. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P15770"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P15770 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P15770.json""}]"	""
pathwaymech:MIBiG_BGC0000829_edge-001_93f41dbb8785	NCBIProtein:BAA84782.1	pathwaymech:enables	MIBiG:BGC0000829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MIBiG:BGC0000828|NCBIProtein:BAA84782.1|PMID:17925955	vioA product from the JCM 1249 assay locus contributes within the VioABED enzyme mixture that produced pathway precursor protoviolaceinic acid (compound 8). This supports an enables edge, not isolated elementary catalysis. The differing AF172851.1 protein is not substituted.	"[{""reference_id"": ""NCBIProtein:BAA84782.1"", ""source_assertion"": ""BAA84782.1 is annotated as Vio A; its CDS is assigned to gene vio A and encoded by AB032799.1:552..1808."", ""source_locator"": ""GBSet/GBSeq[GBSeq_accession-version='BAA84782.1']/GBSeq_feature-table/GBFeature[GBFeature_key='Protein' or GBFeature_key='CDS']/GBFeature_quals""}, {""reference_id"": ""MIBiG:BGC0000828"", ""source_assertion"": ""Retired BGC0000828 assigns the violacein cluster to AB032799.1 and explicitly identifies BGC0000829 as its duplicate successor. This is cluster identity lineage, not protein sequence equivalence."", ""source_locator"": ""$.status; $.loci[0].accession; $.compounds[0].name; $.retirement_reasons[0]; $.see_also[0]""}, {""quote"": ""VioABED produced 8"", ""reference_id"": ""PMID:17925955""}]"	"[{""id"": ""MIBiG:BGC0000828"", ""source_sha256"": ""4b13c7f31da39a944c92481ae365fab196b7fc9b4147456099b38c12b9ea813d"", ""source_version"": ""MIBiG 4.0; retired BGC0000828 entry version 2; exact archive member documented in source manifest"", ""title"": ""Retired MIBiG violacein cluster BGC0000828: AB032799.1 and explicit duplicate successor BGC0000829"", ""url"": ""https://dl.secondarymetabolites.org/mibig/mibig_json_4.0.tar.gz""}, {""id"": ""NCBIProtein:BAA84782.1"", ""source_sha256"": ""2ed3b7577e82bcaf9f0c6e646d47e12eee327b98650204d8f194919e330c95d1"", ""source_version"": ""BAA84782.1; BAA84783.1; BAA84784.1; BAA84785.1; AAQ60934.1 (protein GBSet batch)"", ""title"": ""GenBank BAA84782.1: Vio A from Chromobacterium violaceum"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAA84782.1,BAA84783.1,BAA84784.1,BAA84785.1,AAQ60934.1&rettype=gb&retmode=xml""}, {""citation"": ""Shinoda K et al. Chemical Communications (2007), 4140-4142. doi:10.1039/b705358d."", ""id"": ""PMID:17925955"", ""title"": ""Biosynthesis of violacein: a genuine intermediate, protoviolaceinic acid, produced by VioABDE, and insight into VioC function"", ""url"": ""https://doi.org/10.1039/b705358d""}]"	""
pathwaymech:MIBiG_BGC0000829_edge-002_103c69a5d047	NCBIProtein:BAA84783.1	pathwaymech:enables	MIBiG:BGC0000829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MIBiG:BGC0000828|NCBIProtein:BAA84783.1|PMID:17925955	vioB product from the JCM 1249 assay locus contributes within the VioABED enzyme mixture that produced pathway precursor protoviolaceinic acid (compound 8). This supports an enables edge, not isolated elementary catalysis. The differing AF172851.1 protein is not substituted.	"[{""reference_id"": ""NCBIProtein:BAA84783.1"", ""source_assertion"": ""BAA84783.1 is annotated as Vio B; its CDS is assigned to gene vio B and encoded by AB032799.1:1883..4879."", ""source_locator"": ""GBSet/GBSeq[GBSeq_accession-version='BAA84783.1']/GBSeq_feature-table/GBFeature[GBFeature_key='Protein' or GBFeature_key='CDS']/GBFeature_quals""}, {""reference_id"": ""MIBiG:BGC0000828"", ""source_assertion"": ""Retired BGC0000828 assigns the violacein cluster to AB032799.1 and explicitly identifies BGC0000829 as its duplicate successor. This is cluster identity lineage, not protein sequence equivalence."", ""source_locator"": ""$.status; $.loci[0].accession; $.compounds[0].name; $.retirement_reasons[0]; $.see_also[0]""}, {""quote"": ""VioABED produced 8"", ""reference_id"": ""PMID:17925955""}]"	"[{""id"": ""MIBiG:BGC0000828"", ""source_sha256"": ""4b13c7f31da39a944c92481ae365fab196b7fc9b4147456099b38c12b9ea813d"", ""source_version"": ""MIBiG 4.0; retired BGC0000828 entry version 2; exact archive member documented in source manifest"", ""title"": ""Retired MIBiG violacein cluster BGC0000828: AB032799.1 and explicit duplicate successor BGC0000829"", ""url"": ""https://dl.secondarymetabolites.org/mibig/mibig_json_4.0.tar.gz""}, {""id"": ""NCBIProtein:BAA84783.1"", ""source_sha256"": ""2ed3b7577e82bcaf9f0c6e646d47e12eee327b98650204d8f194919e330c95d1"", ""source_version"": ""BAA84782.1; BAA84783.1; BAA84784.1; BAA84785.1; AAQ60934.1 (protein GBSet batch)"", ""title"": ""GenBank BAA84783.1: Vio B from Chromobacterium violaceum"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAA84782.1,BAA84783.1,BAA84784.1,BAA84785.1,AAQ60934.1&rettype=gb&retmode=xml""}, {""citation"": ""Shinoda K et al. Chemical Communications (2007), 4140-4142. doi:10.1039/b705358d."", ""id"": ""PMID:17925955"", ""title"": ""Biosynthesis of violacein: a genuine intermediate, protoviolaceinic acid, produced by VioABDE, and insight into VioC function"", ""url"": ""https://doi.org/10.1039/b705358d""}]"	""
pathwaymech:MIBiG_BGC0000829_edge-003_343cc1e57b2a	NCBIProtein:BAA84784.1	pathwaymech:enables	MIBiG:BGC0000829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MIBiG:BGC0000828|NCBIProtein:BAA84784.1|PMID:17925955	The AB032799.1 VioC enzyme accepts the assayed pathway precursors protoviolaceinic acid (compound 8) and protodeoxyviolaceinic acid (compound 9). This supports a gene-product contribution; final spontaneous chemistry is not assigned to VioC catalysis.	"[{""reference_id"": ""NCBIProtein:BAA84784.1"", ""source_assertion"": ""BAA84784.1 is annotated as Vio C; its CDS is assigned to gene vio C and encoded by AB032799.1:4881..6170."", ""source_locator"": ""GBSet/GBSeq[GBSeq_accession-version='BAA84784.1']/GBSeq_feature-table/GBFeature[GBFeature_key='Protein' or GBFeature_key='CDS']/GBFeature_quals""}, {""reference_id"": ""MIBiG:BGC0000828"", ""source_assertion"": ""Retired BGC0000828 assigns the violacein cluster to AB032799.1 and explicitly identifies BGC0000829 as its duplicate successor. This is cluster identity lineage, not protein sequence equivalence."", ""source_locator"": ""$.status; $.loci[0].accession; $.compounds[0].name; $.retirement_reasons[0]; $.see_also[0]""}, {""quote"": ""VioC accepts only 8 and 9"", ""reference_id"": ""PMID:17925955""}]"	"[{""id"": ""MIBiG:BGC0000828"", ""source_sha256"": ""4b13c7f31da39a944c92481ae365fab196b7fc9b4147456099b38c12b9ea813d"", ""source_version"": ""MIBiG 4.0; retired BGC0000828 entry version 2; exact archive member documented in source manifest"", ""title"": ""Retired MIBiG violacein cluster BGC0000828: AB032799.1 and explicit duplicate successor BGC0000829"", ""url"": ""https://dl.secondarymetabolites.org/mibig/mibig_json_4.0.tar.gz""}, {""id"": ""NCBIProtein:BAA84784.1"", ""source_sha256"": ""2ed3b7577e82bcaf9f0c6e646d47e12eee327b98650204d8f194919e330c95d1"", ""source_version"": ""BAA84782.1; BAA84783.1; BAA84784.1; BAA84785.1; AAQ60934.1 (protein GBSet batch)"", ""title"": ""GenBank BAA84784.1: Vio C from Chromobacterium violaceum"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAA84782.1,BAA84783.1,BAA84784.1,BAA84785.1,AAQ60934.1&rettype=gb&retmode=xml""}, {""citation"": ""Shinoda K et al. Chemical Communications (2007), 4140-4142. doi:10.1039/b705358d."", ""id"": ""PMID:17925955"", ""title"": ""Biosynthesis of violacein: a genuine intermediate, protoviolaceinic acid, produced by VioABDE, and insight into VioC function"", ""url"": ""https://doi.org/10.1039/b705358d""}]"	""
pathwaymech:MIBiG_BGC0000829_edge-004_32d536078876	NCBIProtein:BAA84785.1	pathwaymech:enables	MIBiG:BGC0000829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MIBiG:BGC0000828|NCBIProtein:BAA84785.1|PMID:17925955	vioD product from the JCM 1249 assay locus contributes within the VioABED enzyme mixture that produced pathway precursor protoviolaceinic acid (compound 8). This supports an enables edge, not isolated elementary catalysis. The differing AF172851.1 protein is not substituted.	"[{""reference_id"": ""NCBIProtein:BAA84785.1"", ""source_assertion"": ""BAA84785.1 is annotated as Vio D; its CDS is assigned to gene vio D and encoded by AB032799.1:6170..7291."", ""source_locator"": ""GBSet/GBSeq[GBSeq_accession-version='BAA84785.1']/GBSeq_feature-table/GBFeature[GBFeature_key='Protein' or GBFeature_key='CDS']/GBFeature_quals""}, {""reference_id"": ""MIBiG:BGC0000828"", ""source_assertion"": ""Retired BGC0000828 assigns the violacein cluster to AB032799.1 and explicitly identifies BGC0000829 as its duplicate successor. This is cluster identity lineage, not protein sequence equivalence."", ""source_locator"": ""$.status; $.loci[0].accession; $.compounds[0].name; $.retirement_reasons[0]; $.see_also[0]""}, {""quote"": ""VioABED produced 8"", ""reference_id"": ""PMID:17925955""}]"	"[{""id"": ""MIBiG:BGC0000828"", ""source_sha256"": ""4b13c7f31da39a944c92481ae365fab196b7fc9b4147456099b38c12b9ea813d"", ""source_version"": ""MIBiG 4.0; retired BGC0000828 entry version 2; exact archive member documented in source manifest"", ""title"": ""Retired MIBiG violacein cluster BGC0000828: AB032799.1 and explicit duplicate successor BGC0000829"", ""url"": ""https://dl.secondarymetabolites.org/mibig/mibig_json_4.0.tar.gz""}, {""id"": ""NCBIProtein:BAA84785.1"", ""source_sha256"": ""2ed3b7577e82bcaf9f0c6e646d47e12eee327b98650204d8f194919e330c95d1"", ""source_version"": ""BAA84782.1; BAA84783.1; BAA84784.1; BAA84785.1; AAQ60934.1 (protein GBSet batch)"", ""title"": ""GenBank BAA84785.1: Vio D from Chromobacterium violaceum"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAA84782.1,BAA84783.1,BAA84784.1,BAA84785.1,AAQ60934.1&rettype=gb&retmode=xml""}, {""citation"": ""Shinoda K et al. Chemical Communications (2007), 4140-4142. doi:10.1039/b705358d."", ""id"": ""PMID:17925955"", ""title"": ""Biosynthesis of violacein: a genuine intermediate, protoviolaceinic acid, produced by VioABDE, and insight into VioC function"", ""url"": ""https://doi.org/10.1039/b705358d""}]"	""
pathwaymech:MIBiG_BGC0000829_edge-005_979c214ab3bf	NCBIProtein:AAQ60934.1	pathwaymech:enables	MIBiG:BGC0000829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MIBiG:BGC0000828|NCBIProtein:AAQ60934.1|PMID:17925955	VioE is resolved by exact 191-aa translation of AB032799.1:7301..7873, followed by TAG, matching deposited AAQ60934.1. The paper amplified vioE from this AB plasmid. The NCBI protein label remains hypothetical protein; no equivalent VioE translation was found in AF172851.1.	"[{""reference_id"": ""NCBIProtein:AAQ60934.1"", ""source_assertion"": ""AAQ60934.1 is a 191-aa protein of Chromobacterium violaceum ATCC 12472, encoded by CV_3270 at complement(AE016825.1:3558964..3559539); its Region annotation identifies the VioE domain."", ""source_locator"": ""GBSet/GBSeq[GBSeq_accession-version='AAQ60934.1']/GBSeq_feature-table/GBFeature[GBFeature_key='source' or GBFeature_key='Region' or GBFeature_key='CDS']/GBFeature_quals""}, {""quote"": ""VioE is essential"", ""reference_id"": ""PMID:17925955""}, {""reference_id"": ""MIBiG:BGC0000828"", ""source_assertion"": ""Retired BGC0000828 assigns the violacein cluster to AB032799.1 and explicitly identifies BGC0000829 as its duplicate successor. This is cluster identity lineage, not protein sequence equivalence."", ""source_locator"": ""$.status; $.loci[0].accession; $.compounds[0].name; $.retirement_reasons[0]; $.see_also[0]""}]"	"[{""id"": ""MIBiG:BGC0000828"", ""source_sha256"": ""4b13c7f31da39a944c92481ae365fab196b7fc9b4147456099b38c12b9ea813d"", ""source_version"": ""MIBiG 4.0; retired BGC0000828 entry version 2; exact archive member documented in source manifest"", ""title"": ""Retired MIBiG violacein cluster BGC0000828: AB032799.1 and explicit duplicate successor BGC0000829"", ""url"": ""https://dl.secondarymetabolites.org/mibig/mibig_json_4.0.tar.gz""}, {""id"": ""NCBIProtein:AAQ60934.1"", ""source_sha256"": ""2ed3b7577e82bcaf9f0c6e646d47e12eee327b98650204d8f194919e330c95d1"", ""source_version"": ""BAA84782.1; BAA84783.1; BAA84784.1; BAA84785.1; AAQ60934.1 (protein GBSet batch)"", ""title"": ""GenBank AAQ60934.1: hypothetical protein from Chromobacterium violaceum"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAA84782.1,BAA84783.1,BAA84784.1,BAA84785.1,AAQ60934.1&rettype=gb&retmode=xml""}, {""citation"": ""Shinoda K et al. Chemical Communications (2007), 4140-4142. doi:10.1039/b705358d."", ""id"": ""PMID:17925955"", ""title"": ""Biosynthesis of violacein: a genuine intermediate, protoviolaceinic acid, produced by VioABDE, and insight into VioC function"", ""url"": ""https://doi.org/10.1039/b705358d""}]"	""
pathwaymech:MIBiG_BGC0000829_edge-006_0df78c83d534	MIBiG:BGC0000829	pathwaymech:produces	CHEBI:131914	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MIBiG:BGC0000829|PMID:17925955	The JCM 1249 AB032799.1 cell-free system produces violacein (compound 1): VioABE-derived extract was supplied to VioCD with NADPH. The endpoint includes nonenzymatic oxidative decarboxylation after the last enzyme; this is not a direct VioC-to-violacein catalysis assertion.	"[{""quote"": ""leading to the production of 1"", ""reference_id"": ""PMID:17925955""}, {""reference_id"": ""MIBiG:BGC0000829"", ""source_assertion"": ""MIBiG BGC0000829 records violacein as the cluster product. The native entry is active, quality questionable, completeness complete; those source flags are preserved without upgrading experimental certainty."", ""source_locator"": ""$.compounds[0].name; $.status; $.quality; $.completeness""}]"	"[{""id"": ""MIBiG:BGC0000829"", ""source_sha256"": ""8582cb5e8fa698cd21acc3e9e2a4da91da60c35ad5ee9159ec56848442078f49"", ""source_version"": ""MIBiG 4.0; entry version 5"", ""title"": ""MIBiG violacein cluster BGC0000829, entry version 5"", ""url"": ""https://mibig.secondarymetabolites.org/repository/BGC0000829.5/annotations.json""}, {""citation"": ""Shinoda K et al. Chemical Communications (2007), 4140-4142. doi:10.1039/b705358d."", ""id"": ""PMID:17925955"", ""title"": ""Biosynthesis of violacein: a genuine intermediate, protoviolaceinic acid, produced by VioABDE, and insight into VioC function"", ""url"": ""https://doi.org/10.1039/b705358d""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-001_e799c6f128f8	CHEBI:57328	pathwaymech:consumes	RHEA:15118	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15117	Coefficient 1 in the selected activation direction, preserving the Rhea charge and stereochemical form.	"[{""reference_id"": ""RHEA:15117"", ""source_assertion"": ""RHEA:15118 substrates contain CHEBI:57328 with coefficient 1; the compound is 3'-dephospho-CoA."", ""source_locator"": ""http://rdf.rhea-db.org/15118 rh:substrates; http://rdf.rhea-db.org/15117_L rh:contains1 http://rdf.rhea-db.org/Participant_15117_compound_1509; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15117"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:15117 and activation direction RHEA:15118"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-002_9602dba42cff	CHEBI:30616	pathwaymech:consumes	RHEA:15118	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15117	Coefficient 1 in the selected activation direction, preserving the Rhea charge and stereochemical form.	"[{""reference_id"": ""RHEA:15117"", ""source_assertion"": ""RHEA:15118 substrates contain CHEBI:30616 with coefficient 1; the compound is ATP."", ""source_locator"": ""http://rdf.rhea-db.org/15118 rh:substrates; http://rdf.rhea-db.org/15117_L rh:contains1 http://rdf.rhea-db.org/Participant_15117_compound_6372; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15117"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:15117 and activation direction RHEA:15118"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-003_d5ead159348b	RHEA:15118	pathwaymech:produces	CHEBI:61378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15117	Coefficient 1 in the selected activation direction, preserving the Rhea charge and stereochemical form.	"[{""reference_id"": ""RHEA:15117"", ""source_assertion"": ""RHEA:15118 products contain CHEBI:61378 with coefficient 1; the compound is 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA."", ""source_locator"": ""http://rdf.rhea-db.org/15118 rh:products; http://rdf.rhea-db.org/15117_R rh:contains1 http://rdf.rhea-db.org/Participant_15117_compound_6441; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15117"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:15117 and activation direction RHEA:15118"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-004_2a6bceb2661c	RHEA:15118	pathwaymech:produces	CHEBI:16708	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15117	Coefficient 1 in the selected activation direction, preserving the Rhea charge and stereochemical form.	"[{""reference_id"": ""RHEA:15117"", ""source_assertion"": ""RHEA:15118 products contain CHEBI:16708 with coefficient 1; the compound is adenine."", ""source_locator"": ""http://rdf.rhea-db.org/15118 rh:products; http://rdf.rhea-db.org/15117_R rh:contains1 http://rdf.rhea-db.org/Participant_15117_compound_4174; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15117"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:15117 and activation direction RHEA:15118"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-005_389fc95109e7	RHEA-COMP:10157	pathwaymech:consumes	RHEA:16334	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16333|UniProtKB:P0A6G5	Coefficient 1 of a whole generic citrate-lyase ACP polypeptide state. Its ChEBI reactive-part residue is not substituted for the complete carrier; no sequence-specific identity is asserted.	"[{""reference_id"": ""RHEA:16333"", ""source_assertion"": ""RHEA:16334 substrates contain GENERIC:10157 with coefficient 1; the compound is apo-[citrate lyase ACP]."", ""source_locator"": ""http://rdf.rhea-db.org/16334 rh:substrates; http://rdf.rhea-db.org/16333_L rh:contains1 http://rdf.rhea-db.org/Participant_16333_compound_10157; rh:compound/rh:accession""}, {""reference_id"": ""UniProtKB:P0A6G5"", ""source_assertion"": ""The catalytic-activity Rhea cross-references include RHEA-COMP:10157, the whole ACP state represented by native Rhea Compound_10157."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences[database=\""Rhea\""]""}]"	"[{""id"": ""RHEA:16333"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:16333 and activation direction RHEA:16334"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0A6G5"", ""source_sha256"": ""c8388822ec4739b4e0d385b50567c60b4b2caf2382c184259ab9027a4df14744"", ""source_version"": ""Reviewed entry version 120; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6G5.json""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-006_7ba6a61c4a70	CHEBI:61378	pathwaymech:consumes	RHEA:16334	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16333	Coefficient 1 in the selected activation direction, preserving the Rhea charge and stereochemical form.	"[{""reference_id"": ""RHEA:16333"", ""source_assertion"": ""RHEA:16334 substrates contain CHEBI:61378 with coefficient 1; the compound is 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA."", ""source_locator"": ""http://rdf.rhea-db.org/16334 rh:substrates; http://rdf.rhea-db.org/16333_L rh:contains1 http://rdf.rhea-db.org/Participant_16333_compound_6441; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16333"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:16333 and activation direction RHEA:16334"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-007_c7d5a8372edb	RHEA:16334	pathwaymech:produces	RHEA-COMP:10158	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16333|UniProtKB:P0A6G5	Coefficient 1 of a whole generic citrate-lyase ACP polypeptide state. Its ChEBI reactive-part residue is not substituted for the complete carrier; no sequence-specific identity is asserted.	"[{""reference_id"": ""RHEA:16333"", ""source_assertion"": ""RHEA:16334 products contain GENERIC:10158 with coefficient 1; the compound is holo-[citrate lyase ACP]."", ""source_locator"": ""http://rdf.rhea-db.org/16334 rh:products; http://rdf.rhea-db.org/16333_R rh:contains1 http://rdf.rhea-db.org/Participant_16333_compound_10158; rh:compound/rh:accession""}, {""reference_id"": ""UniProtKB:P0A6G5"", ""source_assertion"": ""The catalytic-activity Rhea cross-references include RHEA-COMP:10158, the whole ACP state represented by native Rhea Compound_10158."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences[database=\""Rhea\""]""}]"	"[{""id"": ""RHEA:16333"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:16333 and activation direction RHEA:16334"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0A6G5"", ""source_sha256"": ""c8388822ec4739b4e0d385b50567c60b4b2caf2382c184259ab9027a4df14744"", ""source_version"": ""Reviewed entry version 120; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6G5.json""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-008_1d4e0f729291	RHEA:16334	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16333	Coefficient 1 in the selected activation direction, preserving the Rhea charge and stereochemical form.	"[{""reference_id"": ""RHEA:16333"", ""source_assertion"": ""RHEA:16334 products contain CHEBI:33019 with coefficient 1; the compound is diphosphate."", ""source_locator"": ""http://rdf.rhea-db.org/16334 rh:products; http://rdf.rhea-db.org/16333_R rh:contains1 http://rdf.rhea-db.org/Participant_16333_compound_2106; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16333"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:16333 and activation direction RHEA:16334"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-009_82842abe8402	RHEA-COMP:10158	pathwaymech:consumes	RHEA:23789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23788|UniProtKB:P77390	Coefficient 1 of a whole generic citrate-lyase ACP polypeptide state. Its ChEBI reactive-part residue is not substituted for the complete carrier; no sequence-specific identity is asserted.	"[{""reference_id"": ""RHEA:23788"", ""source_assertion"": ""RHEA:23789 substrates contain GENERIC:10158 with coefficient 1; the compound is holo-[citrate lyase ACP]."", ""source_locator"": ""http://rdf.rhea-db.org/23789 rh:substrates; http://rdf.rhea-db.org/23788_L rh:contains1 http://rdf.rhea-db.org/Participant_23788_compound_10158; rh:compound/rh:accession""}, {""reference_id"": ""UniProtKB:P77390"", ""source_assertion"": ""The catalytic-activity Rhea cross-references include RHEA-COMP:10158, the whole ACP state represented by native Rhea Compound_10158."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences[database=\""Rhea\""]""}]"	"[{""id"": ""RHEA:23788"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:23788 and activation direction RHEA:23789"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P77390"", ""source_sha256"": ""388100336eb5d367760e6c3d5862ecbbb2fee1cf24b2b344dace85639cbec9d2"", ""source_version"": ""Reviewed entry version 167; sequence version 2; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""[Citrate [pro-3S]-lyase] ligase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77390.json""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-010_19c46afb4b68	CHEBI:30089	pathwaymech:consumes	RHEA:23789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23788	Coefficient 1 in the selected activation direction, preserving the Rhea charge and stereochemical form.	"[{""reference_id"": ""RHEA:23788"", ""source_assertion"": ""RHEA:23789 substrates contain CHEBI:30089 with coefficient 1; the compound is acetate."", ""source_locator"": ""http://rdf.rhea-db.org/23789 rh:substrates; http://rdf.rhea-db.org/23788_L rh:contains1 http://rdf.rhea-db.org/Participant_23788_compound_6051; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23788"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:23788 and activation direction RHEA:23789"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-011_a119f149a366	CHEBI:30616	pathwaymech:consumes	RHEA:23789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23788	Coefficient 1 in the selected activation direction, preserving the Rhea charge and stereochemical form.	"[{""reference_id"": ""RHEA:23788"", ""source_assertion"": ""RHEA:23789 substrates contain CHEBI:30616 with coefficient 1; the compound is ATP."", ""source_locator"": ""http://rdf.rhea-db.org/23789 rh:substrates; http://rdf.rhea-db.org/23788_L rh:contains1 http://rdf.rhea-db.org/Participant_23788_compound_6372; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23788"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:23788 and activation direction RHEA:23789"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-012_757db909fc12	RHEA:23789	pathwaymech:produces	RHEA-COMP:13710	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23788|UniProtKB:P77390	Coefficient 1 of a whole generic citrate-lyase ACP polypeptide state. Its ChEBI reactive-part residue is not substituted for the complete carrier; no sequence-specific identity is asserted.	"[{""reference_id"": ""RHEA:23788"", ""source_assertion"": ""RHEA:23789 products contain GENERIC:13710 with coefficient 1; the compound is acetyl-[citrate lyase ACP]."", ""source_locator"": ""http://rdf.rhea-db.org/23789 rh:products; http://rdf.rhea-db.org/23788_R rh:contains1 http://rdf.rhea-db.org/Participant_23788_compound_13710; rh:compound/rh:accession""}, {""reference_id"": ""UniProtKB:P77390"", ""source_assertion"": ""The catalytic-activity Rhea cross-references include RHEA-COMP:13710, the whole ACP state represented by native Rhea Compound_13710."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences[database=\""Rhea\""]""}]"	"[{""id"": ""RHEA:23788"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:23788 and activation direction RHEA:23789"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P77390"", ""source_sha256"": ""388100336eb5d367760e6c3d5862ecbbb2fee1cf24b2b344dace85639cbec9d2"", ""source_version"": ""Reviewed entry version 167; sequence version 2; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""[Citrate [pro-3S]-lyase] ligase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77390.json""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-013_d3aa7a429752	RHEA:23789	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23788	Coefficient 1 in the selected activation direction, preserving the Rhea charge and stereochemical form.	"[{""reference_id"": ""RHEA:23788"", ""source_assertion"": ""RHEA:23789 products contain CHEBI:456215 with coefficient 1; the compound is AMP."", ""source_locator"": ""http://rdf.rhea-db.org/23789 rh:products; http://rdf.rhea-db.org/23788_R rh:contains1 http://rdf.rhea-db.org/Participant_23788_compound_2590; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23788"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:23788 and activation direction RHEA:23789"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-014_9ec787e550ab	RHEA:23789	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23788	Coefficient 1 in the selected activation direction, preserving the Rhea charge and stereochemical form.	"[{""reference_id"": ""RHEA:23788"", ""source_assertion"": ""RHEA:23789 products contain CHEBI:33019 with coefficient 1; the compound is diphosphate."", ""source_locator"": ""http://rdf.rhea-db.org/23789 rh:products; http://rdf.rhea-db.org/23788_R rh:contains1 http://rdf.rhea-db.org/Participant_23788_compound_2106; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23788"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:23788 and activation direction RHEA:23789"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-015_0e9b879a64c0	UniProtKB:P77231	pathwaymech:catalyzes	RHEA:15118	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11042274|UniProtKB:P77231	CitG synthesizes the prosthetic-group precursor. The native reaction frame retains the obsolete EC-like name 2.7.8.25-RXN, but its current enzyme classification is EC 2.4.2.52.	"[{""reference_id"": ""UniProtKB:P77231"", ""source_assertion"": ""The reviewed catalytic-activity comment assigns RHEA:15117 with experimental evidence ECO:0000269 from PMID:11042274."", ""source_locator"": ""comments[1].reaction; reactionCrossReferences; evidences""}, {""reference_id"": ""PMID:11042274"", ""source_assertion"": ""CitG converts ATP and dephospho-CoA to adenine and triphosphoribosyl-dephospho-CoA, identifying the precursor proposed in the preceding study."", ""source_locator"": ""Europe PMC core result[id=\""11042274\""].abstractText""}]"	"[{""id"": ""PMID:11042274"", ""source_sha256"": ""ae1fe40a496c1fb91f4a30112b75ebb330dbce81a6e32f3facaacd236c8112e2"", ""source_version"": ""Primary abstract in Europe PMC core; DOI 10.1016/s0014-5793(00)02105-0; retrieved 2026-10-10; digest covers exact JSON response"", ""title"": ""Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A11042274%20AND%20SRC%3AMED&format=json&resultType=core""}, {""id"": ""UniProtKB:P77231"", ""source_sha256"": ""2abd096e22cd277b7b552495b6dd323b5ee5f311e748a8d245fb67a540d53a5e"", ""source_version"": ""Reviewed entry version 152; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77231.json""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-016_c190712d7c45	UniProtKB:P0A6G5	pathwaymech:catalyzes	RHEA:16334	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:10924139|PMID:11042274|UniProtKB:P0A6G5	CitX transfers the precursor to apo-ACP to produce holo-ACP. The separately demonstrated ATP-dependent adenylylation side reaction does not make AMP-ACP a pathway intermediate.	"[{""reference_id"": ""UniProtKB:P0A6G5"", ""source_assertion"": ""The reviewed catalytic-activity comment assigns RHEA:16333 with experimental evidence ECO:0000269 from PMID:10924139 and PMID:11042274."", ""source_locator"": ""comments[1].reaction; reactionCrossReferences; evidences""}, {""quote"": ""this precursor was transferred by CitX to apo-ACP, yielding holo-ACP."", ""reference_id"": ""PMID:11042274"", ""source_locator"": ""Europe PMC core result[id=\""11042274\""].abstractText""}, {""reference_id"": ""PMID:10924139"", ""source_assertion"": ""Purified CitG and CitX convert apo-ACP to holo-ACP with ATP and dephospho-CoA; AMP-ACP cannot be converted further and is a side product."", ""source_locator"": ""Europe PMC core result[id=\""10924139\""].abstractText""}]"	"[{""id"": ""PMID:10924139"", ""source_sha256"": ""4dccb4c0599e39e4102d14ef25c1926b62a012d06492e0aea4b0622e5735114c"", ""source_version"": ""Primary abstract in Europe PMC core; DOI 10.1021/bi000401r; retrieved 2026-10-10; digest covers exact JSON response"", ""title"": ""Biosynthesis of the prosthetic group of citrate lyase."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A10924139%20AND%20SRC%3AMED&format=json&resultType=core""}, {""id"": ""PMID:11042274"", ""source_sha256"": ""ae1fe40a496c1fb91f4a30112b75ebb330dbce81a6e32f3facaacd236c8112e2"", ""source_version"": ""Primary abstract in Europe PMC core; DOI 10.1016/s0014-5793(00)02105-0; retrieved 2026-10-10; digest covers exact JSON response"", ""title"": ""Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A11042274%20AND%20SRC%3AMED&format=json&resultType=core""}, {""id"": ""UniProtKB:P0A6G5"", ""source_sha256"": ""c8388822ec4739b4e0d385b50567c60b4b2caf2382c184259ab9027a4df14744"", ""source_version"": ""Reviewed entry version 120; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6G5.json""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-017_13e65f8d1119	UniProtKB:P77390	pathwaymech:catalyzes	RHEA:23789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:6354265|UniProtKB:P77390	CitC acetylates the holo-ACP prosthetic-group thiol with acetate and ATP. Its exact sequence assignment is supported by reviewed annotation and an explicit curated direct-assay mapping; the inspected primary abstract establishes E. coli ligase activity, not independently verified purification of accession P77390.	"[{""reference_id"": ""UniProtKB:P77390"", ""source_assertion"": ""The reviewed catalytic-activity comment assigns RHEA:23788 and EC 6.2.1.22. This comment has no inline experimental ECO tag."", ""source_locator"": ""comments[1].reaction; reactionCrossReferences""}, {""reference_id"": ""UniProtKB:P77390"", ""source_assertion"": ""The GO:0008771 cross-reference has IDA:EcoCyc evidence ECO:0000314 citing PMID:6354265. This is an inspected database attribution, not independent inspection of the full experiment."", ""source_locator"": ""uniProtKBCrossReferences[database=\""GO\"",id=\""GO:0008771\""].properties; evidences""}, {""quote"": ""A ligase which acetylates the deacetyl[citrate lyase] in the presence of acetate and ATP"", ""reference_id"": ""PMID:6354265"", ""source_locator"": ""Europe PMC core result[id=\""6354265\""].abstractText, final sentence; abstract truncated at 250 words""}]"	"[{""id"": ""PMID:6354265"", ""source_sha256"": ""ae2214c67694c78febd8336927e60dd9bef00fb862f1546481bb0f7cc7593552"", ""source_version"": ""Primary abstract in Europe PMC core; DOI 10.1021/bi00289a008; retrieved 2026-10-10; digest covers exact JSON response; abstract truncated at 250 words"", ""title"": ""Purification and properties of citrate lyase from Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A6354265%20AND%20SRC%3AMED&format=json&resultType=core""}, {""id"": ""UniProtKB:P77390"", ""source_sha256"": ""388100336eb5d367760e6c3d5862ecbbb2fee1cf24b2b344dace85639cbec9d2"", ""source_version"": ""Reviewed entry version 167; sequence version 2; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""[Citrate [pro-3S]-lyase] ligase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77390.json""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-018_b0f5b9f777f2	RHEA:15118	BFO:0000050	MetaCyc:P2-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:P2-PWY|RHEA:15117	This activation reaction belongs to the retained E. coli core. Membership does not transfer the source diagram's other-species branches into this organism.	"[{""reference_id"": ""MetaCyc:P2-PWY"", ""source_assertion"": ""P2-PWY explicitly lists 2.7.8.25-RXN as a pathway reaction."", ""source_locator"": ""Pathway[@frameid=\""P2-PWY\""]/reaction-list""}, {""reference_id"": ""RHEA:15117"", ""source_assertion"": ""RHEA:15118 has a seeAlso cross-reference to MetaCyc 2.7.8.25-RXN; RHEA:15117 lists RHEA:15118 as a directional reaction."", ""source_locator"": ""http://rdf.rhea-db.org/15118 rdfs:seeAlso http://identifiers.org/biocyc/METACYC:2.7.8.25-RXN; http://rdf.rhea-db.org/15117 rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:P2-PWY"", ""source_sha256"": ""8e12d1a7b0351c9cb1713d5000431f2f66d4ac35f1162ee1a412d72e4ec86f21"", ""source_version"": ""MetaCyc Pathway Tools 22.5; public XML retrieved 2026-10-10; exact response digest"", ""title"": ""MetaCyc P2-PWY native citrate lyase activation pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:P2-PWY""}, {""id"": ""RHEA:15117"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:15117 and activation direction RHEA:15118"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-019_b8357a35dd24	RHEA:16334	BFO:0000050	MetaCyc:P2-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:P2-PWY|RHEA:16333	This activation reaction belongs to the retained E. coli core. Membership does not transfer the source diagram's other-species branches into this organism.	"[{""reference_id"": ""MetaCyc:P2-PWY"", ""source_assertion"": ""P2-PWY explicitly lists 2.7.7.61-RXN as a pathway reaction."", ""source_locator"": ""Pathway[@frameid=\""P2-PWY\""]/reaction-list""}, {""reference_id"": ""RHEA:16333"", ""source_assertion"": ""RHEA:16334 has a seeAlso cross-reference to MetaCyc 2.7.7.61-RXN; RHEA:16333 lists RHEA:16334 as a directional reaction."", ""source_locator"": ""http://rdf.rhea-db.org/16334 rdfs:seeAlso http://identifiers.org/biocyc/METACYC:2.7.7.61-RXN; http://rdf.rhea-db.org/16333 rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:P2-PWY"", ""source_sha256"": ""8e12d1a7b0351c9cb1713d5000431f2f66d4ac35f1162ee1a412d72e4ec86f21"", ""source_version"": ""MetaCyc Pathway Tools 22.5; public XML retrieved 2026-10-10; exact response digest"", ""title"": ""MetaCyc P2-PWY native citrate lyase activation pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:P2-PWY""}, {""id"": ""RHEA:16333"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:16333 and activation direction RHEA:16334"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-020_ca5db7b8cab1	RHEA:23789	BFO:0000050	MetaCyc:P2-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:P2-PWY|RHEA:23788	This activation reaction belongs to the retained E. coli core. Membership does not transfer the source diagram's other-species branches into this organism.	"[{""reference_id"": ""MetaCyc:P2-PWY"", ""source_assertion"": ""P2-PWY explicitly lists CITC-RXN as a pathway reaction."", ""source_locator"": ""Pathway[@frameid=\""P2-PWY\""]/reaction-list""}, {""reference_id"": ""RHEA:23788"", ""source_assertion"": ""RHEA:23789 has a seeAlso cross-reference to MetaCyc CITC-RXN; RHEA:23788 lists RHEA:23789 as a directional reaction."", ""source_locator"": ""http://rdf.rhea-db.org/23789 rdfs:seeAlso http://identifiers.org/biocyc/METACYC:CITC-RXN; http://rdf.rhea-db.org/23788 rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:P2-PWY"", ""source_sha256"": ""8e12d1a7b0351c9cb1713d5000431f2f66d4ac35f1162ee1a412d72e4ec86f21"", ""source_version"": ""MetaCyc Pathway Tools 22.5; public XML retrieved 2026-10-10; exact response digest"", ""title"": ""MetaCyc P2-PWY native citrate lyase activation pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:P2-PWY""}, {""id"": ""RHEA:23788"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:23788 and activation direction RHEA:23789"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-021_6fc7cb7b24b1	RHEA:15118	RO:0002413	RHEA:16334	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15117|RHEA:16333	CitG supplies the precursor consumed by CitX; this is material transfer, not a claimed stable CitG–CitX complex or direct channeling interaction.	"[{""reference_id"": ""RHEA:15117"", ""source_assertion"": ""RHEA:15118 produces CHEBI:61378."", ""source_locator"": ""http://rdf.rhea-db.org/15118 rh:products; rh:contains1/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:16333"", ""source_assertion"": ""RHEA:16334 consumes CHEBI:61378."", ""source_locator"": ""http://rdf.rhea-db.org/16334 rh:substrates; rh:contains1/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15117"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:15117 and activation direction RHEA:15118"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:16333"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:16333 and activation direction RHEA:16334"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_P2-PWY_citrate-edge-022_e56581063a3e	RHEA:16334	RO:0002413	RHEA:23789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16333|RHEA:23788	CitX supplies holo-ACP for CitC acetylation. The same whole carrier state is shared by the two reactions.	"[{""reference_id"": ""RHEA:16333"", ""source_assertion"": ""RHEA:16334 produces Compound_10158 (GENERIC:10158), normalized as RHEA-COMP:10158."", ""source_locator"": ""http://rdf.rhea-db.org/16334 rh:products; rh:contains1/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:23788"", ""source_assertion"": ""RHEA:23789 consumes Compound_10158 (GENERIC:10158), normalized as RHEA-COMP:10158."", ""source_locator"": ""http://rdf.rhea-db.org/23789 rh:substrates; rh:contains1/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16333"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:16333 and activation direction RHEA:16334"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:23788"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers the complete compressed official RDF"", ""title"": ""RHEA:23788 and activation direction RHEA:23789"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-001_e0ab403aabf2	gomodel:ORNCARBAMTRANSFER-RXN	RO:0002234	CHEBI:57743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:ORNCARBAMTRANSFER-RXN RO:0002234 gomodel:CHEBI_57743_ORNCARBAMTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/0; endpoint types: /individuals/14/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-002_17caf7cc37c4	gomodel:CARBPSYN-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002234 gomodel:CHEBI_43474_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/1; endpoint types: /individuals/0/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-003_1765c8fad03d	gomodel:CARBPSYN-RXN	RO:0002233	CHEBI:17544	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002233 gomodel:CHEBI_17544_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/2; endpoint types: /individuals/0/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-004_09447222363f	gomodel:CARBPSYN-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002234 gomodel:CHEBI_456216_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/3; endpoint types: /individuals/0/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-005_77569a16e1a9	gomodel:CARBPSYN-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002233 gomodel:CHEBI_15377_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/4; endpoint types: /individuals/0/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-006_157d8ff870a1	gomodel:ORNCARBAMTRANSFER-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:ORNCARBAMTRANSFER-RXN RO:0002234 gomodel:CHEBI_43474_ORNCARBAMTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/5; endpoint types: /individuals/14/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-007_7022bffde720	gomodel:ORNCARBAMTRANSFER-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:ORNCARBAMTRANSFER-RXN RO:0002234 gomodel:CHEBI_15378_ORNCARBAMTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/6; endpoint types: /individuals/14/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-008_1a1528180114	gomodel:CARBPSYN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002234 gomodel:CHEBI_15378_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/7; endpoint types: /individuals/0/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-009_23c43f5092ff	gomodel:CARBPSYN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN BFO:0000066 gomodel:reaction_CARBPSYN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/8; endpoint types: /individuals/0/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-010_48bc8a7fd622	gomodel:CARBPSYN-RXN	BFO:0000050	GO:0019240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN BFO:0000050 gomodel:YeastPathways_CITRUL-BIO2-PWY/YeastPathways_CITRUL-BIO2-PWY."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/9; endpoint types: /individuals/0/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-011_129b435ba6c5	gomodel:CARBPSYN-RXN	RO:0002234	CHEBI:58228	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002234 gomodel:CHEBI_58228_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/10; endpoint types: /individuals/0/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-012_cdfd8bc411e3	SGD:S000217863	pathwaymech:enables	gomodel:CARBPSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002333 gomodel:YeastPathways_CITRUL-BIO2-PWY/6690711d00000301."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/11; endpoint types: /individuals/0/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-013_7faa7c4ff45d	SGD:S000003624	pathwaymech:enables	gomodel:ORNCARBAMTRANSFER-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:ORNCARBAMTRANSFER-RXN RO:0002333 gomodel:YJL088W-MONOMER_ORNCARBAMTRANSFER-RXN_controller."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/12; endpoint types: /individuals/14/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-014_9ddebd6ea046	gomodel:CARBPSYN-RXN	RO:0002234	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002234 gomodel:CHEBI_29985_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/13; endpoint types: /individuals/0/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-015_83685328e48b	gomodel:CARBPSYN-RXN	RO:0002233	CHEBI:58359	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002233 gomodel:CHEBI_58359_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/14; endpoint types: /individuals/0/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-016_1e9ac071bc02	gomodel:ORNCARBAMTRANSFER-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:ORNCARBAMTRANSFER-RXN BFO:0000066 gomodel:reaction_ORNCARBAMTRANSFER-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/15; endpoint types: /individuals/14/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-017_6e462475c806	gomodel:ORNCARBAMTRANSFER-RXN	RO:0002233	CHEBI:46911	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:ORNCARBAMTRANSFER-RXN RO:0002233 gomodel:CHEBI_46911_ORNCARBAMTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/16; endpoint types: /individuals/14/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-018_9098c7ce65c1	gomodel:CARBPSYN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002233 gomodel:CHEBI_30616_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/17; endpoint types: /individuals/0/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-019_62853882900f	gomodel:ORNCARBAMTRANSFER-RXN	RO:0002233	CHEBI:58228	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:ORNCARBAMTRANSFER-RXN RO:0002233 gomodel:CHEBI_58228_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/18; endpoint types: /individuals/14/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_edge-020_52cd052f8d87	gomodel:ORNCARBAMTRANSFER-RXN	BFO:0000050	GO:0019240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_CITRUL-BIO2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_assertion"": ""The model asserts gomodel:ORNCARBAMTRANSFER-RXN BFO:0000050 gomodel:YeastPathways_CITRUL-BIO2-PWY/YeastPathways_CITRUL-BIO2-PWY."", ""source_locator"": ""./YeastPathways_CITRUL-BIO2-PWY.json#/facts/19; endpoint types: /individuals/14/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_CITRUL-BIO2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_CITRUL-BIO2-PWY.json"", ""title"": ""SGD GO-CAM citrulline biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_complex-a5ebe22a52c9_49ff305ab516	SGD:S000217863	BFO:0000051	SGD:S000005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217863|gomodel:YeastPathways_ARGSYNBSUB-PWY	ECO:0000353: physical interaction evidence; source stoichiometry minValue: 1, maxValue: 1	"[{""reference_id"": ""SGD:S000217863"", ""source_assertion"": ""Complex Portal CPX-579 lists P07258 as a protein component; complex evidence is ECO:0000353: physical interaction evidence."", ""source_locator"": ""Complex Portal JSON #/participants/0; /evidenceType""}, {""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:CPLX3O-887_CARBPSYN-RXN_controller BFO:0000051 gomodel:SGD_S000005829_CPLX3O-887_component."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/78; endpoint types: /individuals/44/type; /individuals/50/type""}]"	"[{""id"": ""SGD:S000217863"", ""source_sha256"": ""ccbb1369177abe4083a66a31055b2e69ff26d38506e4c8a7e063ed786a2194cc"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-579: Carbamoyl-phosphate synthase arginine-specific"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-579""}, {""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_complex-061be8221b03_d62ba2073c9e	SGD:S000217863	BFO:0000051	SGD:S000003870	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217863|gomodel:YeastPathways_ARGSYNBSUB-PWY	ECO:0000353: physical interaction evidence; source stoichiometry minValue: 1, maxValue: 1	"[{""reference_id"": ""SGD:S000217863"", ""source_assertion"": ""Complex Portal CPX-579 lists P03965 as a protein component; complex evidence is ECO:0000353: physical interaction evidence."", ""source_locator"": ""Complex Portal JSON #/participants/1; /evidenceType""}, {""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:CPLX3O-887_CARBPSYN-RXN_controller BFO:0000051 gomodel:SGD_S000003870_CPLX3O-887_component."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/9; endpoint types: /individuals/44/type; /individuals/49/type""}]"	"[{""id"": ""SGD:S000217863"", ""source_sha256"": ""ccbb1369177abe4083a66a31055b2e69ff26d38506e4c8a7e063ed786a2194cc"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-579: Carbamoyl-phosphate synthase arginine-specific"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-579""}, {""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_complex-1dcec51f57f8_b6a1f8336de9	SGD:S000217863	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217863	Complex location from the independent composition source; original GO-CAM activity locations are retained with their own provenance.	"[{""reference_id"": ""SGD:S000217863"", ""source_assertion"": ""Complex Portal CPX-579 records cellular location GO:0005737 (cytoplasm); its evidence classification is ECO:0000353: physical interaction evidence."", ""source_locator"": ""Complex Portal JSON #/crossReferences/9; /evidenceType""}]"	"[{""id"": ""SGD:S000217863"", ""source_sha256"": ""ccbb1369177abe4083a66a31055b2e69ff26d38506e4c8a7e063ed786a2194cc"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-579: Carbamoyl-phosphate synthase arginine-specific"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-579""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_location-77e173e27741_483fd86bfe09	SGD:S000003624	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05150	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P05150"", ""source_assertion"": ""UniProtKB:P05150 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/100/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P05150"", ""source_assertion"": ""UniProtKB:P05150 has the exact SGD cross-reference SGD:S000003624."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/100/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P05150"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P05150 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_location-10342e417b5d_33ffa3b0a991	SGD:S000003870	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P03965	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:200419); ECO:0000269 (PubMed:205532)	"[{""reference_id"": ""UniProtKB:P03965"", ""source_assertion"": ""UniProtKB:P03965 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/75/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P03965"", ""source_assertion"": ""UniProtKB:P03965 has the exact SGD cross-reference SGD:S000003870."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/75/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P03965"", ""source_sha256"": ""2ad9b6d84d565238960a053870fa90a6033bc212bbe1a4c9923fd55d7e7d7fc1"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P03965 SGD cross-reference"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_location-e1da57d9d9b3_0af3b555bbd6	SGD:S000005829	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07258	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:200419); ECO:0000269 (PubMed:205532)	"[{""reference_id"": ""UniProtKB:P07258"", ""source_assertion"": ""UniProtKB:P07258 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/169/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07258"", ""source_assertion"": ""UniProtKB:P07258 has the exact SGD cross-reference SGD:S000005829."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/169/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07258"", ""source_sha256"": ""2ad9b6d84d565238960a053870fa90a6033bc212bbe1a4c9923fd55d7e7d7fc1"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07258 SGD cross-reference"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_cofactor-9da6898b0c4d_11f29552fc8a	SGD:S000003870	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P03965	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (PROSITE-ProRule:PRU00409) Binds 4 Mg(2+) or Mn(2+) ions per subunit. UniProt note evidence: ECO:0000255 (PROSITE-ProRule:PRU00409)	"[{""reference_id"": ""UniProtKB:P03965"", ""source_assertion"": ""UniProtKB:P03965 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/75/comments/0/cofactors/0; /results/75/comments/0/note""}, {""reference_id"": ""UniProtKB:P03965"", ""source_assertion"": ""UniProtKB:P03965 has the exact SGD cross-reference SGD:S000003870."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/75/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P03965"", ""source_sha256"": ""2ad9b6d84d565238960a053870fa90a6033bc212bbe1a4c9923fd55d7e7d7fc1"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P03965 SGD cross-reference"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_CITRUL-BIO2-PWY_cofactor-39cceffa6749_43f0f7ee3507	SGD:S000003870	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P03965	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (PROSITE-ProRule:PRU00409) Binds 4 Mg(2+) or Mn(2+) ions per subunit. UniProt note evidence: ECO:0000255 (PROSITE-ProRule:PRU00409)	"[{""reference_id"": ""UniProtKB:P03965"", ""source_assertion"": ""UniProtKB:P03965 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/75/comments/0/cofactors/1; /results/75/comments/0/note""}, {""reference_id"": ""UniProtKB:P03965"", ""source_assertion"": ""UniProtKB:P03965 has the exact SGD cross-reference SGD:S000003870."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/75/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P03965"", ""source_sha256"": ""2ad9b6d84d565238960a053870fa90a6033bc212bbe1a4c9923fd55d7e7d7fc1"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P03965 SGD cross-reference"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-001_70bbe1c02385	CHEBI:10986	pathwaymech:consumes	RHEA:19398	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19398		"[{""reference_id"": ""RHEA:19398"", ""source_assertion"": ""Rhea lists CHEBI:10986 on the substrates side of RHEA:19398 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19398']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19398"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantothenoylcysteine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19398""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-002_f3b8e44d5676	CHEBI:35235	pathwaymech:consumes	RHEA:19398	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19398		"[{""reference_id"": ""RHEA:19398"", ""source_assertion"": ""Rhea lists CHEBI:35235 on the substrates side of RHEA:19398 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19398']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19398"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantothenoylcysteine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19398""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-003_c1459f76a6c1	CHEBI:37563	pathwaymech:consumes	RHEA:19398	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19398		"[{""reference_id"": ""RHEA:19398"", ""source_assertion"": ""Rhea lists CHEBI:37563 on the substrates side of RHEA:19398 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19398']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19398"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantothenoylcysteine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19398""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-004_a80fc602ebda	RHEA:19398	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19398		"[{""reference_id"": ""RHEA:19398"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:19398 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19398']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19398"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantothenoylcysteine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19398""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-005_210e8b2cb8f1	RHEA:19398	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19398		"[{""reference_id"": ""RHEA:19398"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:19398 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19398']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19398"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantothenoylcysteine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19398""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-006_b5e2d12aab3e	RHEA:19398	pathwaymech:produces	CHEBI:59458	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19398		"[{""reference_id"": ""RHEA:19398"", ""source_assertion"": ""Rhea lists CHEBI:59458 on the products side of RHEA:19398 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19398']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19398"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantothenoylcysteine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19398""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-007_fb73603825ca	RHEA:19398	pathwaymech:produces	CHEBI:60377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19398		"[{""reference_id"": ""RHEA:19398"", ""source_assertion"": ""Rhea lists CHEBI:60377 on the products side of RHEA:19398 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19398']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19398"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantothenoylcysteine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19398""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-008_ed7dbedbb38b	CHEBI:15378	pathwaymech:consumes	RHEA:16794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16794		"[{""reference_id"": ""RHEA:16794"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:16794 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16794']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16794"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantetheine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16794""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-009_f20d215a9772	CHEBI:59458	pathwaymech:consumes	RHEA:16794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16794		"[{""reference_id"": ""RHEA:16794"", ""source_assertion"": ""Rhea lists CHEBI:59458 on the substrates side of RHEA:16794 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16794']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16794"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantetheine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16794""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-010_10432ba2b1ad	RHEA:16794	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16794		"[{""reference_id"": ""RHEA:16794"", ""source_assertion"": ""Rhea lists CHEBI:16526 on the products side of RHEA:16794 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16794']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16794"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantetheine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16794""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-011_6184aa5a9a7a	RHEA:16794	pathwaymech:produces	CHEBI:61723	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16794		"[{""reference_id"": ""RHEA:16794"", ""source_assertion"": ""Rhea lists CHEBI:61723 on the products side of RHEA:16794 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16794']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16794"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantetheine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16794""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-012_ea7ac12fdffe	CHEBI:15378	pathwaymech:consumes	RHEA:19802	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19802		"[{""reference_id"": ""RHEA:19802"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:19802 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19802']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19802"", ""source_version"": ""139"", ""title"": ""Rhea dephospho-CoA-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19802""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-013_53bfd59e1df2	CHEBI:30616	pathwaymech:consumes	RHEA:19802	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19802		"[{""reference_id"": ""RHEA:19802"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:19802 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19802']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19802"", ""source_version"": ""139"", ""title"": ""Rhea dephospho-CoA-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19802""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-014_74ac17490f21	CHEBI:61723	pathwaymech:consumes	RHEA:19802	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19802		"[{""reference_id"": ""RHEA:19802"", ""source_assertion"": ""Rhea lists CHEBI:61723 on the substrates side of RHEA:19802 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19802']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19802"", ""source_version"": ""139"", ""title"": ""Rhea dephospho-CoA-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19802""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-015_1704d7fbb38c	RHEA:19802	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19802		"[{""reference_id"": ""RHEA:19802"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:19802 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19802']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19802"", ""source_version"": ""139"", ""title"": ""Rhea dephospho-CoA-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19802""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-016_40394126690f	RHEA:19802	pathwaymech:produces	CHEBI:57328	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19802		"[{""reference_id"": ""RHEA:19802"", ""source_assertion"": ""Rhea lists CHEBI:57328 on the products side of RHEA:19802 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19802']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19802"", ""source_version"": ""139"", ""title"": ""Rhea dephospho-CoA-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19802""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-017_df3cd5017270	CHEBI:30616	pathwaymech:consumes	RHEA:18246	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18246		"[{""reference_id"": ""RHEA:18246"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:18246 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18246']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18246"", ""source_version"": ""139"", ""title"": ""Rhea coenzyme A-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18246""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-018_a025f50ad012	CHEBI:57328	pathwaymech:consumes	RHEA:18246	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18246		"[{""reference_id"": ""RHEA:18246"", ""source_assertion"": ""Rhea lists CHEBI:57328 on the substrates side of RHEA:18246 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18246']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18246"", ""source_version"": ""139"", ""title"": ""Rhea coenzyme A-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18246""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-019_87c7ca7683e8	RHEA:18246	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18246		"[{""reference_id"": ""RHEA:18246"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:18246 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18246']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18246"", ""source_version"": ""139"", ""title"": ""Rhea coenzyme A-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18246""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-020_7c286a738c63	RHEA:18246	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18246		"[{""reference_id"": ""RHEA:18246"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:18246 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18246']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18246"", ""source_version"": ""139"", ""title"": ""Rhea coenzyme A-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18246""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-021_9f3c0e19bd62	RHEA:18246	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18246		"[{""reference_id"": ""RHEA:18246"", ""source_assertion"": ""Rhea lists CHEBI:57287 on the products side of RHEA:18246 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18246']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18246"", ""source_version"": ""139"", ""title"": ""Rhea coenzyme A-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18246""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-022_22db72017d83	EC:6.3.2.5	pathwaymech:catalyzes	RHEA:19398	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19397		"[{""reference_id"": ""RHEA:19397"", ""source_assertion"": ""Rhea associates EC:6.3.2.5 with the reaction family containing RHEA:19398."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:19397"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantothenate--cysteine ligase reaction"", ""url"": ""https://www.rhea-db.org/rhea/19397""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-023_67286a2633e0	EC:4.1.1.36	pathwaymech:catalyzes	RHEA:16794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16793		"[{""reference_id"": ""RHEA:16793"", ""source_assertion"": ""Rhea associates EC:4.1.1.36 with the reaction family containing RHEA:16794."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:16793"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantothenoylcysteine decarboxylase reaction"", ""url"": ""https://www.rhea-db.org/rhea/16793""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-024_62ab2318d223	EC:2.7.7.3	pathwaymech:catalyzes	RHEA:19802	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19801		"[{""reference_id"": ""RHEA:19801"", ""source_assertion"": ""Rhea associates EC:2.7.7.3 with the reaction family containing RHEA:19802."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:19801"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantetheine adenylyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/19801""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-025_17dcda375973	EC:2.7.1.24	pathwaymech:catalyzes	RHEA:18246	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18245		"[{""reference_id"": ""RHEA:18245"", ""source_assertion"": ""Rhea associates EC:2.7.1.24 with the reaction family containing RHEA:18246."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:18245"", ""source_version"": ""139"", ""title"": ""Rhea dephospho-CoA kinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/18245""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-026_e67a7c314da3	RHEA:16794	pathwaymech:precedes	RHEA:19802	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:COA-PWY		"[{""reference_id"": ""MetaCyc:COA-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:16794 before RHEA:19802 in this pathway. Shared intermediate: CHEBI:61723."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:COA-PWY"", ""source_sha256"": ""c1e818c9d70e492169bc4b3d5cd0161aaf58b6f56082f3432ca9db08acdc832d"", ""source_version"": ""22.5"", ""title"": ""MetaCyc coenzyme A biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:COA-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-027_d89fb4f7a59e	RHEA:19398	pathwaymech:precedes	RHEA:16794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:COA-PWY		"[{""reference_id"": ""MetaCyc:COA-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:19398 before RHEA:16794 in this pathway. Shared intermediate: CHEBI:59458."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:COA-PWY"", ""source_sha256"": ""c1e818c9d70e492169bc4b3d5cd0161aaf58b6f56082f3432ca9db08acdc832d"", ""source_version"": ""22.5"", ""title"": ""MetaCyc coenzyme A biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:COA-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-028_81c7cb1c34ec	RHEA:19802	pathwaymech:precedes	RHEA:18246	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:COA-PWY		"[{""reference_id"": ""MetaCyc:COA-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:19802 before RHEA:18246 in this pathway. Shared intermediate: CHEBI:57328."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:COA-PWY"", ""source_sha256"": ""c1e818c9d70e492169bc4b3d5cd0161aaf58b6f56082f3432ca9db08acdc832d"", ""source_version"": ""22.5"", ""title"": ""MetaCyc coenzyme A biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:COA-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-029_2f9936cd5228	UniProtKB:P0A6I6	pathwaymech:enables	RHEA:19802	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6I6		"[{""reference_id"": ""UniProtKB:P0A6I6"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A6I6 with catalytic activity for the reaction family of RHEA:19802. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A6I6"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6I6 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6I6.json""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-030_0e6374439f23	CHEBI:57287	pathwaymech:inhibits	UniProtKB:P0A6I6	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6I6		"[{""reference_id"": ""UniProtKB:P0A6I6"", ""source_assertion"": ""UniProt activity-regulation annotation: Feedback inhibited by CoA, which is competitive with ATP, 4'-phosphopantetheine and 3'-dephospho-CoA."", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P0A6I6"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6I6 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6I6.json""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-031_7f17dc625433	UniProtKB:P0A6I6	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6I6		"[{""reference_id"": ""UniProtKB:P0A6I6"", ""source_assertion"": ""UniProt locates UniProtKB:P0A6I6 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A6I6"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6I6 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6I6.json""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-032_2229952115f6	UniProtKB:P0A6I6	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6I6		"[{""reference_id"": ""UniProtKB:P0A6I6"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P0A6I6 (evidence: ECO:0000269). Crystallized in the absence of Mg(2+), the catalytic metal is not bound by the protein but probably by non-esterified oxygen atoms from ATP and/or ordered H(2)O (PubMed:11812124)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0A6I6"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6I6 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6I6.json""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-033_c483cbdda535	UniProtKB:P0A6I9	pathwaymech:enables	RHEA:18246	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6I9		"[{""reference_id"": ""UniProtKB:P0A6I9"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A6I9 with catalytic activity for the reaction family of RHEA:18246. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A6I9"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6I9 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6I9.json""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-034_92e6da0be3e9	UniProtKB:P0A6I9	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6I9		"[{""reference_id"": ""UniProtKB:P0A6I9"", ""source_assertion"": ""UniProt locates UniProtKB:P0A6I9 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255, ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A6I9"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6I9 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6I9.json""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-035_7a21e7b00942	UniProtKB:P0ABQ0	pathwaymech:enables	RHEA:16794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ABQ0		"[{""reference_id"": ""UniProtKB:P0ABQ0"", ""source_assertion"": ""UniProt annotates UniProtKB:P0ABQ0 with catalytic activity for the reaction family of RHEA:16794. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0ABQ0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0ABQ0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABQ0.json""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-036_a9648d8c0f67	UniProtKB:P0ABQ0	pathwaymech:enables	RHEA:19398	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ABQ0		"[{""reference_id"": ""UniProtKB:P0ABQ0"", ""source_assertion"": ""UniProt annotates UniProtKB:P0ABQ0 with catalytic activity for the reaction family of RHEA:19398. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0ABQ0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0ABQ0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABQ0.json""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-037_0502c1b834ad	UniProtKB:P0ABQ0	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ABQ0		"[{""reference_id"": ""UniProtKB:P0ABQ0"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P0ABQ0 (evidence: ECO:0000255, ECO:0000269). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0ABQ0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0ABQ0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABQ0.json""}]"	""
pathwaymech:MetaCyc_COA-PWY_edge-038_6c246dbbf64a	UniProtKB:P0ABQ0	pathwaymech:has_cofactor	CHEBI:58210	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ABQ0		"[{""reference_id"": ""UniProtKB:P0ABQ0"", ""source_assertion"": ""UniProt lists CHEBI:58210 as a cofactor of UniProtKB:P0ABQ0 (evidence: ECO:0000255, ECO:0000269). Binds 1 FMN per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0ABQ0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0ABQ0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABQ0.json""}]"	""
pathwaymech:GO_0036040_curcumin-edge-001_1b630a47e37b	CHEBI:3962	pathwaymech:consumes	RHEA:34821	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34821		"[{""reference_id"": ""RHEA:34821"", ""source_assertion"": ""Rhea RHEA:34821 assigns CHEBI:3962 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34821']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34819_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_34819_compound_7627']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:34821"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 of exact gzip response body"", ""title"": ""Rhea 34821, directed curcumin pathway reduction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0036040_curcumin-edge-002_772441f8caa1	CHEBI:57783	pathwaymech:consumes	RHEA:34821	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34821		"[{""reference_id"": ""RHEA:34821"", ""source_assertion"": ""Rhea RHEA:34821 assigns CHEBI:57783 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34821']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34819_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_34819_compound_3438']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:34821"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 of exact gzip response body"", ""title"": ""Rhea 34821, directed curcumin pathway reduction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0036040_curcumin-edge-003_f138bc8dd638	CHEBI:15378	pathwaymech:consumes	RHEA:34821	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34821		"[{""reference_id"": ""RHEA:34821"", ""source_assertion"": ""Rhea RHEA:34821 assigns CHEBI:15378 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34821']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34819_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_34819_compound_3249']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:34821"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 of exact gzip response body"", ""title"": ""Rhea 34821, directed curcumin pathway reduction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0036040_curcumin-edge-004_b2df9d4fd090	RHEA:34821	pathwaymech:produces	CHEBI:67262	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34821		"[{""reference_id"": ""RHEA:34821"", ""source_assertion"": ""Rhea RHEA:34821 assigns CHEBI:67262 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34821']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34819_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_34819_compound_7626']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:34821"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 of exact gzip response body"", ""title"": ""Rhea 34821, directed curcumin pathway reduction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0036040_curcumin-edge-005_1cbe9054e651	RHEA:34821	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34821		"[{""reference_id"": ""RHEA:34821"", ""source_assertion"": ""Rhea RHEA:34821 assigns CHEBI:58349 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34821']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34819_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_34819_compound_5188']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:34821"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 of exact gzip response body"", ""title"": ""Rhea 34821, directed curcumin pathway reduction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0036040_curcumin-edge-006_aaa0934ea9de	CHEBI:67262	pathwaymech:consumes	RHEA:34813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34813		"[{""reference_id"": ""RHEA:34813"", ""source_assertion"": ""Rhea RHEA:34813 assigns CHEBI:67262 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34813']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34811_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_34811_compound_7626']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:34813"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 of exact gzip response body"", ""title"": ""Rhea 34813, directed curcumin pathway reduction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0036040_curcumin-edge-007_3ee0665bf09b	CHEBI:57783	pathwaymech:consumes	RHEA:34813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34813		"[{""reference_id"": ""RHEA:34813"", ""source_assertion"": ""Rhea RHEA:34813 assigns CHEBI:57783 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34813']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34811_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_34811_compound_3438']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:34813"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 of exact gzip response body"", ""title"": ""Rhea 34813, directed curcumin pathway reduction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0036040_curcumin-edge-008_d2eec3d7b30b	CHEBI:15378	pathwaymech:consumes	RHEA:34813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34813		"[{""reference_id"": ""RHEA:34813"", ""source_assertion"": ""Rhea RHEA:34813 assigns CHEBI:15378 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34813']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34811_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_34811_compound_3249']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:34813"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 of exact gzip response body"", ""title"": ""Rhea 34813, directed curcumin pathway reduction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0036040_curcumin-edge-009_9ae5e2bd658a	RHEA:34813	pathwaymech:produces	CHEBI:67263	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34813		"[{""reference_id"": ""RHEA:34813"", ""source_assertion"": ""Rhea RHEA:34813 assigns CHEBI:67263 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34813']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34811_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_34811_compound_7625']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:34813"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 of exact gzip response body"", ""title"": ""Rhea 34813, directed curcumin pathway reduction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0036040_curcumin-edge-010_cd261a3aed23	RHEA:34813	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34813		"[{""reference_id"": ""RHEA:34813"", ""source_assertion"": ""Rhea RHEA:34813 assigns CHEBI:58349 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34813']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34811_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_34811_compound_5188']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:34813"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 of exact gzip response body"", ""title"": ""Rhea 34813, directed curcumin pathway reduction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0036040_curcumin-edge-011_2044323efb4c	MetaCyc:CPLX0-7927	pathwaymech:catalyzes	RHEA:34821	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN0-6676|PMID:21467222|UniProtKB:P76113	The same supported homodimer catalyzes both reductions. These are experimentally supported enzyme reactions, not a claim that curcumin is the only possible CurA substrate.	"[{""reference_id"": ""MetaCyc:RXN0-6676"", ""source_assertion"": ""RXN0-6676 assigns CPLX0-7927 as the enzyme through ENZRXN0-7454, with the native reduction in its left-to-right orientation."", ""source_locator"": ""Reaction[@frameid=\""RXN0-6676\""]/enzymatic-reaction/Enzymatic-Reaction[@frameid=\""ENZRXN0-7454\""]/enzyme; left; right; reaction-direction""}, {""reference_id"": ""UniProtKB:P76113"", ""source_assertion"": ""Reviewed K-12 CurA assigns curcumin to dihydrocurcumin to physiological RHEA:34821, citing ECO:0000269 PMID:21467222. Its homodimer annotation cites the same experiment."", ""source_locator"": ""/comments/3/reaction; /comments/3/physiologicalReactions; /comments/6""}, {""reference_id"": ""PMID:21467222"", ""source_assertion"": ""Purified CurA produces DHC and THC; the time course places DHC between curcumin and THC. The inspected experiments identify both products by mass spectrometry and UV-visible spectra."", ""source_locator"": ""PMC3080977: Results, Identification of the Reaction Products; Discussion; Figures 2, 3 and 4""}, {""reference_id"": ""PMID:21467222"", ""source_assertion"": ""The study detected activity in K-12 DH10B and used it for purification and gene identification; later enzyme analyses used recombinant CurA in a BL21 expression host."", ""source_locator"": ""PMC3080977: Results, Discovery of Curcumin-Converting Microorganisms; Cloning of the Gene Encoding the Curcumin-Converting Enzyme; Overexpression and Purification""}, {""reference_id"": ""UniProtKB:P76113"", ""source_assertion"": ""Reviewed CurA is assigned to taxon 83333, Escherichia coli K-12, with experimental functional and homodimer evidence from PMID:21467222."", ""source_locator"": ""/organism/taxonId; /comments/0; /comments/6""}]"	"[{""id"": ""MetaCyc:RXN0-6676"", ""source_sha256"": ""ce8dcb7c10f8cb0155921c0e61a8152889b8849159a508a91510ce38a4a0d867"", ""source_version"": ""MetaCyc 22.5 public mirror XML; retrieved 2026-10-11"", ""title"": ""MetaCyc RXN0-6676, native curcumin pathway object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-6676""}, {""id"": ""PMID:21467222"", ""source_sha256"": ""0087006dfbb589812da82459f7e09000d4d48eab7c537a13cce676d62fec2e65"", ""source_version"": ""2011; full PMC article HTML retrieved 2026-10-11"", ""title"": ""Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3080977/?report=xml""}, {""id"": ""UniProtKB:P76113"", ""source_sha256"": ""bd0d8f2a0e9532eb832736ca6bfbada22c279d412b0ac00c7f0384ee65e41a38"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P76113, NADPH-dependent curcumin/dihydrocurcumin reductase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P76113.json""}]"	""
pathwaymech:GO_0036040_curcumin-edge-012_4f8f298a3cc8	MetaCyc:CPLX0-7927	pathwaymech:catalyzes	RHEA:34813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN0-6677|PMID:21467222|UniProtKB:P76113	The same supported homodimer catalyzes both reductions. These are experimentally supported enzyme reactions, not a claim that curcumin is the only possible CurA substrate.	"[{""reference_id"": ""MetaCyc:RXN0-6677"", ""source_assertion"": ""RXN0-6677 assigns CPLX0-7927 as the enzyme through ENZRXN0-7455, with the native reduction in its left-to-right orientation."", ""source_locator"": ""Reaction[@frameid=\""RXN0-6677\""]/enzymatic-reaction/Enzymatic-Reaction[@frameid=\""ENZRXN0-7455\""]/enzyme; left; right; reaction-direction""}, {""reference_id"": ""UniProtKB:P76113"", ""source_assertion"": ""Reviewed K-12 CurA assigns dihydrocurcumin to tetrahydrocurcumin to physiological RHEA:34813, citing ECO:0000269 PMID:21467222. Its homodimer annotation cites the same experiment."", ""source_locator"": ""/comments/2/reaction; /comments/2/physiologicalReactions; /comments/6""}, {""reference_id"": ""PMID:21467222"", ""source_assertion"": ""Purified CurA produces DHC and THC; the time course places DHC between curcumin and THC. The inspected experiments identify both products by mass spectrometry and UV-visible spectra."", ""source_locator"": ""PMC3080977: Results, Identification of the Reaction Products; Discussion; Figures 2, 3 and 4""}]"	"[{""id"": ""MetaCyc:RXN0-6677"", ""source_sha256"": ""b1950fc1e039487cab36defde216e4a0649f9ff68e9d718b89a2c2c4537b0205"", ""source_version"": ""MetaCyc 22.5 public mirror XML; retrieved 2026-10-11"", ""title"": ""MetaCyc RXN0-6677, native curcumin pathway object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-6677""}, {""id"": ""PMID:21467222"", ""source_sha256"": ""0087006dfbb589812da82459f7e09000d4d48eab7c537a13cce676d62fec2e65"", ""source_version"": ""2011; full PMC article HTML retrieved 2026-10-11"", ""title"": ""Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3080977/?report=xml""}, {""id"": ""UniProtKB:P76113"", ""source_sha256"": ""bd0d8f2a0e9532eb832736ca6bfbada22c279d412b0ac00c7f0384ee65e41a38"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P76113, NADPH-dependent curcumin/dihydrocurcumin reductase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P76113.json""}]"	""
pathwaymech:GO_0036040_curcumin-edge-013_74d3eb1f7f5b	UniProtKB:P76113	BFO:0000050	MetaCyc:CPLX0-7927	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7927|MetaCyc:G6760-MONOMER|PMID:21467222	Native complex membership agrees with the gel-filtration/SDS-PAGE homodimer assignment; the protein node is not asserted to be a sufficient monomeric catalyst.	"[{""reference_id"": ""MetaCyc:CPLX0-7927"", ""source_assertion"": ""CPLX0-7927 contains two G6760-MONOMER subunits; its experimental mass is 82 kDa."", ""source_locator"": ""Protein[@frameid=\""CPLX0-7927\""]/component/Protein; component/coefficient; molecular-weight-exp""}, {""reference_id"": ""MetaCyc:G6760-MONOMER"", ""source_assertion"": ""G6760-MONOMER has an explicit UNIPROT P76113 unification cross-reference."", ""source_locator"": ""Protein[@frameid=\""G6760-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid; dblink-relationship""}, {""quote"": ""the enzyme consists of two identical subunits."", ""reference_id"": ""PMID:21467222"", ""source_locator"": ""PMC3080977: Results, Molecular mass, UV-Absorption of the Curcumin-Converting Enzyme""}]"	"[{""id"": ""MetaCyc:CPLX0-7927"", ""source_sha256"": ""f672f616d46ee50d7351f5c5b5bfa942a0e20c7a9a29e3286ad9933ac7b80886"", ""source_version"": ""MetaCyc 22.5 public mirror XML; retrieved 2026-10-11"", ""title"": ""MetaCyc CPLX0-7927, native curcumin pathway object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7927""}, {""id"": ""MetaCyc:G6760-MONOMER"", ""source_sha256"": ""f7fa7990d25d304aa0e45e244e644a40343352075746e329e35e15045a2e3d99"", ""source_version"": ""MetaCyc 22.5 public mirror XML; retrieved 2026-10-11"", ""title"": ""MetaCyc G6760-MONOMER, native curcumin pathway object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G6760-MONOMER""}, {""id"": ""PMID:21467222"", ""source_sha256"": ""0087006dfbb589812da82459f7e09000d4d48eab7c537a13cce676d62fec2e65"", ""source_version"": ""2011; full PMC article HTML retrieved 2026-10-11"", ""title"": ""Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3080977/?report=xml""}]"	""
pathwaymech:GO_0036040_curcumin-edge-014_25bb521c4ce3	RHEA:34821	BFO:0000050	GO:0036040	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0036040|MetaCyc:PWY0-1527|RHEA:34821		"[{""reference_id"": ""GO:0036040"", ""source_assertion"": ""GO:0036040 denotes curcumin catabolic process, includes the exact synonym curcumin degradation, and cites PMID:21467222 for its definition."", ""source_locator"": ""/results/0/name; /results/0/definition; /results/0/synonyms""}, {""reference_id"": ""MetaCyc:PWY0-1527"", ""source_assertion"": ""PWY0-1527 contains RXN0-6676; its ordered route is RXN0-6676 followed by RXN0-6677, from curcumin through dihydrocurcumin to tetrahydrocurcumin."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1527\""]/reaction-list; reaction-ordering; reaction-layout""}, {""reference_id"": ""RHEA:34821"", ""source_assertion"": ""RHEA:34821 explicitly cross-references MetaCyc RXN0-6676; master RHEA:34819 links this directed variant. The selected substrates and products follow the native reduction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34821']/rdfs:seeAlso; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34819']/rh:directionalReaction; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34821']/rh:substrates; rh:products""}]"	"[{""id"": ""GO:0036040"", ""source_sha256"": ""83e343c17b49b6800e3e32aa07fc27bf98a74c00e921a195d76a72708f64d386"", ""source_version"": ""QuickGO response retrieved 2026-10-11"", ""title"": ""Gene Ontology curcumin catabolic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0036040""}, {""id"": ""MetaCyc:PWY0-1527"", ""source_sha256"": ""5f55b220915a56d6b0ea4b941487d024b852a14db9e8a1efc6d7c298c0ec86ed"", ""source_version"": ""MetaCyc 22.5 public mirror XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY0-1527, native curcumin pathway object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1527""}, {""id"": ""RHEA:34821"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 of exact gzip response body"", ""title"": ""Rhea 34821, directed curcumin pathway reduction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0036040_curcumin-edge-015_451196d96a96	RHEA:34813	BFO:0000050	GO:0036040	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1527|RHEA:34813		"[{""reference_id"": ""MetaCyc:PWY0-1527"", ""source_assertion"": ""PWY0-1527 contains RXN0-6677; its ordered route is RXN0-6676 followed by RXN0-6677, from curcumin through dihydrocurcumin to tetrahydrocurcumin."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1527\""]/reaction-list; reaction-ordering; reaction-layout""}, {""reference_id"": ""RHEA:34813"", ""source_assertion"": ""RHEA:34813 explicitly cross-references MetaCyc RXN0-6677; master RHEA:34811 links this directed variant. The selected substrates and products follow the native reduction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34813']/rdfs:seeAlso; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34811']/rh:directionalReaction; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34813']/rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY0-1527"", ""source_sha256"": ""5f55b220915a56d6b0ea4b941487d024b852a14db9e8a1efc6d7c298c0ec86ed"", ""source_version"": ""MetaCyc 22.5 public mirror XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY0-1527, native curcumin pathway object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1527""}, {""id"": ""RHEA:34813"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); SHA256 of exact gzip response body"", ""title"": ""Rhea 34813, directed curcumin pathway reduction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0036040_curcumin-edge-016_8fa90066f0d0	MetaCyc:CPLX0-7927	pathwaymech:has_cofactor	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21467222	NADPH is the freely supplied redox cosubstrate consumed by both reactions. This edge does not imply a permanently bound prosthetic group or a metal requirement.	"[{""reference_id"": ""PMID:21467222"", ""source_assertion"": ""CurA activity lost on dialysis recovered after NADPH addition; NADH did not restore it. The paper identifies NADPH-dependent conversion in both steps."", ""source_locator"": ""PMC3080977: Results, Addition of Various Cofactors to the Curcumin-Converting Enzyme; Discussion""}]"	"[{""id"": ""PMID:21467222"", ""source_sha256"": ""0087006dfbb589812da82459f7e09000d4d48eab7c537a13cce676d62fec2e65"", ""source_version"": ""2011; full PMC article HTML retrieved 2026-10-11"", ""title"": ""Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3080977/?report=xml""}]"	""
pathwaymech:GO_0036040_curcumin-edge-017_8f1ec1ba4da2	UniProtKB:P76113	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:G6760-MONOMER	This is a native computational localization annotation, not a direct localization experiment inspected here; it is not extended to an assertion about transporter identity.	"[{""reference_id"": ""MetaCyc:G6760-MONOMER"", ""source_assertion"": ""G6760-MONOMER is annotated to GO:0005829 with EV-COMP-AINF (computational inference without human oversight) and PMID:19054114; its native location is CCO-CYTOSOL."", ""source_locator"": ""Protein[@frameid=\""G6760-MONOMER\""]/has-go-term[GO-Term/@frameid=\""GO:0005829\""]/evidence; location""}]"	"[{""id"": ""MetaCyc:G6760-MONOMER"", ""source_sha256"": ""f7fa7990d25d304aa0e45e244e644a40343352075746e329e35e15045a2e3d99"", ""source_version"": ""MetaCyc 22.5 public mirror XML; retrieved 2026-10-11"", ""title"": ""MetaCyc G6760-MONOMER, native curcumin pathway object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G6760-MONOMER""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-001_67a75396c69e	CHEBI:29195	pathwaymech:consumes	RHEA:18490	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18490		"[{""reference_id"": ""RHEA:18490"", ""source_assertion"": ""Rhea RHEA:18490 assigns CHEBI:29195 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18490']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/18489_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_18489_compound_1057']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:18490"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 18490 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-002_c9436cbda3da	CHEBI:17544	pathwaymech:consumes	RHEA:18490	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18490		"[{""reference_id"": ""RHEA:18490"", ""source_assertion"": ""Rhea RHEA:18490 assigns CHEBI:17544 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18490']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/18489_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_18489_compound_1123']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:18490"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 18490 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-003_0630578d2fe4	CHEBI:15378	pathwaymech:consumes	RHEA:18490	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18490		"[{""reference_id"": ""RHEA:18490"", ""source_assertion"": ""Rhea RHEA:18490 assigns CHEBI:15378 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18490']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/18489_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_18489_compound_3249']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:18490"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 18490 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-004_eb6092baa644	RHEA:18490	pathwaymech:produces	CHEBI:13941	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18490		"[{""reference_id"": ""RHEA:18490"", ""source_assertion"": ""Rhea RHEA:18490 assigns CHEBI:13941 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18490']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/18489_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_18489_compound_4239']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:18490"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 18490 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-005_ab6e0e2d3933	RHEA:18490	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18490		"[{""reference_id"": ""RHEA:18490"", ""source_assertion"": ""Rhea RHEA:18490 assigns CHEBI:16526 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18490']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/18489_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_18489_compound_4391']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:18490"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 18490 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-006_f0472bec13c8	CHEBI:13941	pathwaymech:consumes	RHEA:15650	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN0-5222|RHEA:15650		"[{""reference_id"": ""RHEA:15650"", ""source_assertion"": ""Rhea RHEA:15650 assigns CHEBI:13941 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15650']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/15649_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_15649_compound_4239']; rh:compound/rh:chebi""}, {""reference_id"": ""MetaCyc:RXN0-5222"", ""source_assertion"": ""MetaCyc RXN0-5222 explicitly sets spontaneous=true for carbamate decomposition to ammonium and carbon dioxide."", ""source_locator"": ""Reaction[@frameid='RXN0-5222']/spontaneous; left; right""}]"	"[{""id"": ""MetaCyc:RXN0-5222"", ""source_sha256"": ""079f6290beaaa757c83d0ef8fdf3e0eeef3ed2c02cd9aa37f8e469e068b21d36"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc RXN0-5222, spontaneous carbamate decomposition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5222""}, {""id"": ""RHEA:15650"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 15650 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-007_09413582b9eb	CHEBI:15378	pathwaymech:consumes	RHEA:15650	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN0-5222|RHEA:15650		"[{""reference_id"": ""RHEA:15650"", ""source_assertion"": ""Rhea RHEA:15650 assigns CHEBI:15378 to its substrates, with coefficient 2 in rh:contains2."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15650']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/15649_L']/rh:contains2[@rdf:resource='http://rdf.rhea-db.org/Participant_15649_compound_3249']; rh:compound/rh:chebi""}, {""reference_id"": ""MetaCyc:RXN0-5222"", ""source_assertion"": ""MetaCyc RXN0-5222 explicitly sets spontaneous=true for carbamate decomposition to ammonium and carbon dioxide."", ""source_locator"": ""Reaction[@frameid='RXN0-5222']/spontaneous; left; right""}]"	"[{""id"": ""MetaCyc:RXN0-5222"", ""source_sha256"": ""079f6290beaaa757c83d0ef8fdf3e0eeef3ed2c02cd9aa37f8e469e068b21d36"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc RXN0-5222, spontaneous carbamate decomposition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5222""}, {""id"": ""RHEA:15650"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 15650 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-008_60f82307bce7	RHEA:15650	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN0-5222|RHEA:15650		"[{""reference_id"": ""RHEA:15650"", ""source_assertion"": ""Rhea RHEA:15650 assigns CHEBI:28938 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15650']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/15649_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_15649_compound_1012']; rh:compound/rh:chebi""}, {""reference_id"": ""MetaCyc:RXN0-5222"", ""source_assertion"": ""MetaCyc RXN0-5222 explicitly sets spontaneous=true for carbamate decomposition to ammonium and carbon dioxide."", ""source_locator"": ""Reaction[@frameid='RXN0-5222']/spontaneous; left; right""}]"	"[{""id"": ""MetaCyc:RXN0-5222"", ""source_sha256"": ""079f6290beaaa757c83d0ef8fdf3e0eeef3ed2c02cd9aa37f8e469e068b21d36"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc RXN0-5222, spontaneous carbamate decomposition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5222""}, {""id"": ""RHEA:15650"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 15650 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-009_ca8cb6e8f3ba	RHEA:15650	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN0-5222|RHEA:15650		"[{""reference_id"": ""RHEA:15650"", ""source_assertion"": ""Rhea RHEA:15650 assigns CHEBI:16526 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15650']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/15649_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_15649_compound_4391']; rh:compound/rh:chebi""}, {""reference_id"": ""MetaCyc:RXN0-5222"", ""source_assertion"": ""MetaCyc RXN0-5222 explicitly sets spontaneous=true for carbamate decomposition to ammonium and carbon dioxide."", ""source_locator"": ""Reaction[@frameid='RXN0-5222']/spontaneous; left; right""}]"	"[{""id"": ""MetaCyc:RXN0-5222"", ""source_sha256"": ""079f6290beaaa757c83d0ef8fdf3e0eeef3ed2c02cd9aa37f8e469e068b21d36"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc RXN0-5222, spontaneous carbamate decomposition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5222""}, {""id"": ""RHEA:15650"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 15650 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-010_5e666146ec39	CHEBI:16526	pathwaymech:consumes	RHEA:10750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750		"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea RHEA:10750 assigns CHEBI:16526 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10750']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/10748_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_10748_compound_4391']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 10750 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-011_f2adab7f61c3	CHEBI:15377	pathwaymech:consumes	RHEA:10750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750		"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea RHEA:10750 assigns CHEBI:15377 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10750']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/10748_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_10748_compound_1283']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 10750 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-012_762037a71e5c	RHEA:10750	pathwaymech:produces	CHEBI:17544	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750		"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea RHEA:10750 assigns CHEBI:17544 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10750']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/10748_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_10748_compound_1123']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 10750 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-013_4bb91d679706	RHEA:10750	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750		"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea RHEA:10750 assigns CHEBI:15378 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10750']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/10748_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_10748_compound_3249']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 10750 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-014_a9891742a4e2	MetaCyc:CYANLY-CPLX	BFO:0000051	UniProtKB:P00816	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CYANLY-CPLX|MetaCyc:CYANLY-MONOMER|PMID:10801492|UniProtKB:P00816	CynS is the cyanase subunit; catalysis belongs to its native homodecamer. MetaCyc supplies the MG1655 assembly assignment, while the structural study concerns E. coli cyanase.	"[{""reference_id"": ""MetaCyc:CYANLY-CPLX"", ""source_assertion"": ""MetaCyc cyanase CYANLY-CPLX contains ten copies of CYANLY-MONOMER."", ""source_locator"": ""Protein[@frameid='CYANLY-CPLX']/component[Protein/@frameid='CYANLY-MONOMER']/coefficient""}, {""reference_id"": ""MetaCyc:CYANLY-MONOMER"", ""source_assertion"": ""MetaCyc CYANLY-MONOMER unifies its protein identity with UniProt P00816."", ""source_locator"": ""Protein[@frameid='CYANLY-MONOMER']/dblink[dblink-db='UNIPROT',dblink-relationship='unification']/dblink-oid""}, {""reference_id"": ""UniProtKB:P00816"", ""source_assertion"": ""Reviewed UniProt P00816 describes a homodecamer made of five homodimers; its SUBUNIT comment has no inline experimental evidence code."", ""source_locator"": ""primaryAccession; comments[commentType='SUBUNIT'].texts""}, {""quote"": ""The enzyme is functionally active as a homodecamer of 17 kDa subunits"", ""reference_id"": ""PMID:10801492"", ""source_locator"": ""Europe PMC core resultList.result[id='10801492'].abstractText, Background""}]"	"[{""id"": ""MetaCyc:CYANLY-CPLX"", ""source_sha256"": ""d01be1fb963b2cf6810652e2384dc62bb95fe1db8054a241e7587cbc78b1b5fc"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc CYANLY-CPLX, cyanase assembly"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYANLY-CPLX""}, {""id"": ""MetaCyc:CYANLY-MONOMER"", ""source_sha256"": ""52f5689607688518f909ab6a57c473aa180b1c1b6004b2405b1be861822bd6d4"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc CYANLY-MONOMER, CynS protein"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYANLY-MONOMER""}, {""id"": ""PMID:10801492"", ""source_sha256"": ""fbed8047b523df94f3c6f6730cfd02f16a08828c582a35ba689cdbe025123907"", ""source_version"": ""Europe PMC core metadata retrieved 2026-10-10"", ""title"": ""Structure of cyanase reveals that a novel dimeric and decameric arrangement of subunits is required for formation of the enzyme active site."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/10801492/""}, {""id"": ""UniProtKB:P00816"", ""source_sha256"": ""42ffef7261c2f41152920f412a89a733fa4c705bc77c9c53b85d1ef4f4a6bd14"", ""source_version"": ""2026_03; retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P00816"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00816.json""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-015_589b9516c967	MetaCyc:CARBODEHYDRAT-CPLX	BFO:0000051	UniProtKB:P0ABE9	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CARBODEHYDRAT-CPLX|MetaCyc:CARBODEHYDRAT-MONOMER|PMID:1740425|UniProtKB:P0ABE9	The graph asserts the CynT component of its own assembly without a fixed oligomer size. It does not adopt the PathBank complex that combines CynT with the distinct Can protein.	"[{""reference_id"": ""MetaCyc:CARBODEHYDRAT-CPLX"", ""source_assertion"": ""MetaCyc CARBODEHYDRAT-CPLX contains CARBODEHYDRAT-MONOMER. Its coefficient 2 is qualified by the component comment as probably a dimer."", ""source_locator"": ""Protein[@frameid='CARBODEHYDRAT-CPLX']/component/Protein; component/coefficient; component/comment""}, {""reference_id"": ""MetaCyc:CARBODEHYDRAT-MONOMER"", ""source_assertion"": ""MetaCyc CARBODEHYDRAT-MONOMER unifies with UniProt P0ABE9; its comment describes oligomers of two or four subunits depending on bicarbonate."", ""source_locator"": ""Protein[@frameid='CARBODEHYDRAT-MONOMER']/dblink[dblink-db='UNIPROT',dblink-relationship='unification']; comment""}, {""reference_id"": ""UniProtKB:P0ABE9"", ""source_assertion"": ""UniProt describes P0ABE9 as an oligomer, with ECO:0000269 citing PMID:1740425."", ""source_locator"": ""comments[commentType='SUBUNIT'].texts""}, {""quote"": ""behave as an oligomer in solution"", ""reference_id"": ""PMID:1740425"", ""source_locator"": ""Europe PMC core resultList.result[id='1740425'].abstractText""}]"	"[{""id"": ""MetaCyc:CARBODEHYDRAT-CPLX"", ""source_sha256"": ""3b3f5d614dbfab6259369c422f57f7d987d079560ad2dd93027cdfb52decd6eb"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc CARBODEHYDRAT-CPLX, carbonic anhydrase 1 assembly"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CARBODEHYDRAT-CPLX""}, {""id"": ""MetaCyc:CARBODEHYDRAT-MONOMER"", ""source_sha256"": ""51720cf32a26f75c730471e00ec89cf9e31ebe6b559da08e94ca6371099f9952"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc CARBODEHYDRAT-MONOMER, CynT protein"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CARBODEHYDRAT-MONOMER""}, {""id"": ""PMID:1740425"", ""source_sha256"": ""df06243c0ed668ce4e1309ed48f85529b8876c78161e7e5527129a99e4574ac5"", ""source_version"": ""Europe PMC core metadata retrieved 2026-10-10"", ""title"": ""Carbonic anhydrase in Escherichia coli. A product of the cyn operon."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/1740425/""}, {""id"": ""UniProtKB:P0ABE9"", ""source_sha256"": ""30187217560b5439f03bc6d16210c8821d4ef168a35c81c78604bbeb3009b64a"", ""source_version"": ""2026_03; retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P0ABE9"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABE9.json""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-016_e0c5cd1f661b	MetaCyc:CYANLY-CPLX	pathwaymech:catalyzes	RHEA:18490	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CYANLY-CPLX|MetaCyc:R524-RXN|PMID:3110153	This is the explicit cyanase conversion to carbamate. Bicarbonate is a substrate, not a cofactor; water is not a substrate of this step. The subsequent nonenzymatic decomposition is a separate node.	"[{""reference_id"": ""MetaCyc:CYANLY-CPLX"", ""source_assertion"": ""MetaCyc CYANLY-CPLX catalyzes CYANLY-ENZRXN, whose reaction is R524-RXN."", ""source_locator"": ""Protein[@frameid='CYANLY-CPLX']/catalyzes/Enzymatic-Reaction[@frameid='CYANLY-ENZRXN']/reaction/Reaction/@frameid""}, {""reference_id"": ""MetaCyc:R524-RXN"", ""source_assertion"": ""MetaCyc R524-RXN forms carbamate and carbon dioxide from cyanate, bicarbonate and a proton; its RHEA unification cross-reference is 18490."", ""source_locator"": ""Reaction[@frameid='R524-RXN']/left; right; dblink[dblink-db='RHEA',dblink-relationship='unification']/dblink-oid""}, {""quote"": ""Bicarbonate (not CO2) is the substrate."", ""reference_id"": ""PMID:3110153"", ""source_locator"": ""Europe PMC core resultList.result[id='3110153'].abstractText""}, {""reference_id"": ""MetaCyc:CYANLY-CPLX"", ""source_assertion"": ""The native cyanase assembly CYANLY-CPLX has species TAX-511145, Escherichia coli K-12 MG1655."", ""source_locator"": ""Protein[@frameid='CYANLY-CPLX']/species/Organism[@frameid='TAX-511145']""}]"	"[{""id"": ""MetaCyc:CYANLY-CPLX"", ""source_sha256"": ""d01be1fb963b2cf6810652e2384dc62bb95fe1db8054a241e7587cbc78b1b5fc"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc CYANLY-CPLX, cyanase assembly"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYANLY-CPLX""}, {""id"": ""MetaCyc:R524-RXN"", ""source_sha256"": ""527dd2a63280a1e13045fb93f61395d95cfe953060aeabacddba6d68fc71bbdb"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc R524-RXN, initial cyanase reaction"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:R524-RXN""}, {""id"": ""PMID:3110153"", ""source_sha256"": ""df06243c0ed668ce4e1309ed48f85529b8876c78161e7e5527129a99e4574ac5"", ""source_version"": ""Europe PMC core metadata retrieved 2026-10-10"", ""title"": ""Bicarbonate is a recycling substrate for cyanase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/3110153/""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-017_759c850c1635	MetaCyc:CARBODEHYDRAT-CPLX	pathwaymech:catalyzes	RHEA:10750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CARBODEHYDRAT-CPLX|MetaCyc:CYANCAT-PWY|MetaCyc:RXN0-5224|RHEA:10750|UniProtKB:P0ABE9	CynT accelerates bicarbonate regeneration. Selecting hydration for this pathway does not make carbonic anhydrase irreversible.	"[{""reference_id"": ""MetaCyc:CARBODEHYDRAT-CPLX"", ""source_assertion"": ""MetaCyc CARBODEHYDRAT-CPLX catalyzes CARBODEHYDRAT-ENZRXN, whose reaction is RXN0-5224."", ""source_locator"": ""Protein[@frameid='CARBODEHYDRAT-CPLX']/catalyzes/Enzymatic-Reaction/reaction/Reaction/@frameid""}, {""reference_id"": ""MetaCyc:RXN0-5224"", ""source_assertion"": ""MetaCyc RXN0-5224 is reversible bicarbonate/proton interconversion with carbon dioxide/water and unifies with bidirectional RHEA:10751."", ""source_locator"": ""Reaction[@frameid='RXN0-5224']/reaction-direction; left; right; dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""MetaCyc:CYANCAT-PWY"", ""source_assertion"": ""The CYANCAT-PWY reaction layout selects RXN0-5224 in R2L direction, consuming carbon dioxide and regenerating bicarbonate."", ""source_locator"": ""Pathway[@frameid='CYANCAT-PWY']/reaction-layout[Reaction/@frameid='RXN0-5224']/direction; left-primaries; right-primaries""}, {""reference_id"": ""UniProtKB:P0ABE9"", ""source_assertion"": ""Reviewed UniProt P0ABE9 assigns the RHEA:10748 carbonic-anhydrase reaction and reversible carbon-dioxide hydration, with ECO:0000269 citing PMID:1740425."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction; comments[commentType='FUNCTION'].texts""}, {""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea RHEA:10750 is the right-to-left member of master RHEA:10748, consuming carbon dioxide and water and producing bicarbonate and a proton."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10748']/rh:directionalReaction; rdf:Description[@rdf:about='http://rdf.rhea-db.org/10750']/rh:substrates and rh:products""}, {""reference_id"": ""MetaCyc:CARBODEHYDRAT-CPLX"", ""source_assertion"": ""The native CynT assembly CARBODEHYDRAT-CPLX has species TAX-511145, Escherichia coli K-12 MG1655."", ""source_locator"": ""Protein[@frameid='CARBODEHYDRAT-CPLX']/species/Organism[@frameid='TAX-511145']""}]"	"[{""id"": ""MetaCyc:CARBODEHYDRAT-CPLX"", ""source_sha256"": ""3b3f5d614dbfab6259369c422f57f7d987d079560ad2dd93027cdfb52decd6eb"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc CARBODEHYDRAT-CPLX, carbonic anhydrase 1 assembly"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CARBODEHYDRAT-CPLX""}, {""id"": ""MetaCyc:CYANCAT-PWY"", ""source_sha256"": ""b17720281237373171f0d50634cdc8119636a945e63db65ad0a1a6681274e4cd"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc CYANCAT-PWY, cyanate degradation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYANCAT-PWY""}, {""id"": ""MetaCyc:RXN0-5224"", ""source_sha256"": ""0f8ea48758c659d86a3f3fb429d73ee60560ab80646e4233481caa7e4cf3ffb5"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc RXN0-5224, reversible carbonic anhydrase reaction"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5224""}, {""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 10750 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0ABE9"", ""source_sha256"": ""30187217560b5439f03bc6d16210c8821d4ef168a35c81c78604bbeb3009b64a"", ""source_version"": ""2026_03; retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P0ABE9"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABE9.json""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-018_c96ec7145f7d	UniProtKB:P0ABE9	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:1740425|UniProtKB:P0ABE9	Zinc binding is supported for the CynT subunit. No bicarbonate cofactor relation is asserted for CynS because bicarbonate participates chemically.	"[{""reference_id"": ""UniProtKB:P0ABE9"", ""source_assertion"": ""UniProt P0ABE9 assigns Zn(2+) CHEBI:29105 and one zinc ion per subunit, with ECO:0000269 citing PMID:1740425."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors; comments[commentType='COFACTOR'].note.texts""}, {""quote"": ""1 Zn2+/subunit (24 kDa)"", ""reference_id"": ""PMID:1740425"", ""source_locator"": ""Europe PMC core resultList.result[id='1740425'].abstractText""}]"	"[{""id"": ""PMID:1740425"", ""source_sha256"": ""df06243c0ed668ce4e1309ed48f85529b8876c78161e7e5527129a99e4574ac5"", ""source_version"": ""Europe PMC core metadata retrieved 2026-10-10"", ""title"": ""Carbonic anhydrase in Escherichia coli. A product of the cyn operon."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/1740425/""}, {""id"": ""UniProtKB:P0ABE9"", ""source_sha256"": ""30187217560b5439f03bc6d16210c8821d4ef168a35c81c78604bbeb3009b64a"", ""source_version"": ""2026_03; retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P0ABE9"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABE9.json""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-019_7dbc397f54c0	RHEA:18490	BFO:0000050	MetaCyc:CYANCAT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CYANCAT-PWY|MetaCyc:R524-RXN	MG1655 scope comes from native pathway and assembly curation. The current reviewed protein entries cover K-12; the 1993 physiology experiments used K-12 derivatives including HfrR5-derived mutants, not a new direct MG1655 experiment.	"[{""reference_id"": ""MetaCyc:CYANCAT-PWY"", ""source_assertion"": ""MetaCyc CYANCAT-PWY explicitly includes R524-RXN in its reaction list."", ""source_locator"": ""Pathway[@frameid='CYANCAT-PWY']/reaction-list/Reaction[@frameid='R524-RXN']""}, {""reference_id"": ""MetaCyc:R524-RXN"", ""source_assertion"": ""MetaCyc R524-RXN has the unification cross-reference RHEA:18490."", ""source_locator"": ""Reaction[@frameid='R524-RXN']/dblink[dblink-db='RHEA',dblink-relationship='unification']/dblink-oid""}, {""reference_id"": ""MetaCyc:CYANCAT-PWY"", ""source_assertion"": ""MetaCyc CYANCAT-PWY explicitly lists Escherichia coli K-12 MG1655 (TAX-511145) among its species."", ""source_locator"": ""Pathway[@frameid='CYANCAT-PWY']/species/Organism[@frameid='TAX-511145']""}]"	"[{""id"": ""MetaCyc:CYANCAT-PWY"", ""source_sha256"": ""b17720281237373171f0d50634cdc8119636a945e63db65ad0a1a6681274e4cd"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc CYANCAT-PWY, cyanate degradation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYANCAT-PWY""}, {""id"": ""MetaCyc:R524-RXN"", ""source_sha256"": ""527dd2a63280a1e13045fb93f61395d95cfe953060aeabacddba6d68fc71bbdb"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc R524-RXN, initial cyanase reaction"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:R524-RXN""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-020_e2859de222f1	RHEA:15650	BFO:0000050	MetaCyc:CYANCAT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CYANCAT-PWY|MetaCyc:RXN0-5222	The spontaneous carbamate decay is retained as a pathway step without an enzyme assignment.	"[{""reference_id"": ""MetaCyc:CYANCAT-PWY"", ""source_assertion"": ""MetaCyc CYANCAT-PWY explicitly includes RXN0-5222 in its reaction list."", ""source_locator"": ""Pathway[@frameid='CYANCAT-PWY']/reaction-list/Reaction[@frameid='RXN0-5222']""}, {""reference_id"": ""MetaCyc:RXN0-5222"", ""source_assertion"": ""MetaCyc RXN0-5222 has the unification cross-reference RHEA:15650."", ""source_locator"": ""Reaction[@frameid='RXN0-5222']/dblink[dblink-db='RHEA',dblink-relationship='unification']/dblink-oid""}]"	"[{""id"": ""MetaCyc:CYANCAT-PWY"", ""source_sha256"": ""b17720281237373171f0d50634cdc8119636a945e63db65ad0a1a6681274e4cd"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc CYANCAT-PWY, cyanate degradation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYANCAT-PWY""}, {""id"": ""MetaCyc:RXN0-5222"", ""source_sha256"": ""079f6290beaaa757c83d0ef8fdf3e0eeef3ed2c02cd9aa37f8e469e068b21d36"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc RXN0-5222, spontaneous carbamate decomposition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5222""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-021_11ed0758ad5c	RHEA:10750	BFO:0000050	MetaCyc:CYANCAT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CYANCAT-PWY|MetaCyc:RXN0-5224|RHEA:10750		"[{""reference_id"": ""MetaCyc:CYANCAT-PWY"", ""source_assertion"": ""MetaCyc CYANCAT-PWY explicitly includes RXN0-5224 in its reaction list."", ""source_locator"": ""Pathway[@frameid='CYANCAT-PWY']/reaction-list/Reaction[@frameid='RXN0-5224']""}, {""reference_id"": ""MetaCyc:RXN0-5224"", ""source_assertion"": ""RXN0-5224 unifies with bidirectional RHEA:10751, and CYANCAT-PWY selects its bicarbonate-regenerating direction."", ""source_locator"": ""Reaction[@frameid='RXN0-5224']/dblink[dblink-db='RHEA']/dblink-oid; reaction-direction""}, {""reference_id"": ""RHEA:10750"", ""source_assertion"": ""RHEA:10751 and directional RHEA:10750 are both members of master RHEA:10748."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10748']/rh:bidirectionalReaction and rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:CYANCAT-PWY"", ""source_sha256"": ""b17720281237373171f0d50634cdc8119636a945e63db65ad0a1a6681274e4cd"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc CYANCAT-PWY, cyanate degradation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYANCAT-PWY""}, {""id"": ""MetaCyc:RXN0-5224"", ""source_sha256"": ""0f8ea48758c659d86a3f3fb429d73ee60560ab80646e4233481caa7e4cf3ffb5"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc RXN0-5224, reversible carbonic anhydrase reaction"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5224""}, {""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 10750 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-022_5d2f7fe3fbac	RHEA:18490	RO:0002413	RHEA:15650	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CYANCAT-PWY	The shared carbamate links these steps. The cycle represents available chemical input, not fixed flux or retention of every carbon dioxide molecule.	"[{""reference_id"": ""MetaCyc:CYANCAT-PWY"", ""source_assertion"": ""CYANCAT-PWY names R524-RXN as a predecessor of RXN0-5222; its reaction layouts identify the shared carbamate pool."", ""source_locator"": ""Pathway[@frameid='CYANCAT-PWY']/reaction-ordering[Reaction/@frameid='RXN0-5222']/predecessor-reactions/Reaction[@frameid='R524-RXN']; reaction-layout""}]"	"[{""id"": ""MetaCyc:CYANCAT-PWY"", ""source_sha256"": ""b17720281237373171f0d50634cdc8119636a945e63db65ad0a1a6681274e4cd"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc CYANCAT-PWY, cyanate degradation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYANCAT-PWY""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-023_01d24389cced	RHEA:15650	RO:0002413	RHEA:10750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CYANCAT-PWY	The shared carbon dioxide links these steps. The cycle represents available chemical input, not fixed flux or retention of every carbon dioxide molecule.	"[{""reference_id"": ""MetaCyc:CYANCAT-PWY"", ""source_assertion"": ""CYANCAT-PWY names RXN0-5222 as a predecessor of RXN0-5224; its reaction layouts identify the shared carbon dioxide pool."", ""source_locator"": ""Pathway[@frameid='CYANCAT-PWY']/reaction-ordering[Reaction/@frameid='RXN0-5224']/predecessor-reactions/Reaction[@frameid='RXN0-5222']; reaction-layout""}]"	"[{""id"": ""MetaCyc:CYANCAT-PWY"", ""source_sha256"": ""b17720281237373171f0d50634cdc8119636a945e63db65ad0a1a6681274e4cd"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc CYANCAT-PWY, cyanate degradation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYANCAT-PWY""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-024_ab363cacc7cf	RHEA:10750	RO:0002413	RHEA:18490	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CYANCAT-PWY|PMID:8444806	The shared bicarbonate links these steps. The cycle represents available chemical input, not fixed flux or retention of every carbon dioxide molecule.	"[{""reference_id"": ""MetaCyc:CYANCAT-PWY"", ""source_assertion"": ""CYANCAT-PWY names RXN0-5224 as a predecessor of R524-RXN; its reaction layouts identify the shared bicarbonate pool."", ""source_locator"": ""Pathway[@frameid='CYANCAT-PWY']/reaction-ordering[Reaction/@frameid='R524-RXN']/predecessor-reactions/Reaction[@frameid='RXN0-5224']; reaction-layout""}, {""reference_id"": ""PMID:8444806"", ""source_assertion"": ""K-12 cynT deletion mutants retained cyanase but failed to degrade cyanate at 0.03% CO2; 3% CO2 rescued the phenotype, supporting a conditional bicarbonate-regeneration role."", ""source_locator"": ""Europe PMC core resultList.result[id='8444806'].abstractText; full article pp.1443,1447-1450""}]"	"[{""id"": ""MetaCyc:CYANCAT-PWY"", ""source_sha256"": ""b17720281237373171f0d50634cdc8119636a945e63db65ad0a1a6681274e4cd"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc CYANCAT-PWY, cyanate degradation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYANCAT-PWY""}, {""id"": ""PMID:8444806"", ""source_sha256"": ""9c6db5e6b7f2138911dcf45b4c9e5a87239947c5b3943820215c9d5a85f55e8e"", ""source_version"": ""Europe PMC core metadata retrieved 2026-10-10"", ""title"": ""A physiological role for cyanate-induced carbonic anhydrase in Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/8444806/""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-025_6fd7497080ba	RHEA:18490	RO:0002413	RHEA:10750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750|RHEA:18490|UniProtKB:P0ABE9	Carbon dioxide from the first step can also enter the shared carbon-dioxide pool used by CynT. This connection is inferred from the explicit intermediate chemistry and documented recycling role; it is not a separate native ordering claim or quantitative carbon-routing measurement.	"[{""reference_id"": ""RHEA:18490"", ""source_assertion"": ""RHEA:18490 directly produces carbon dioxide CHEBI:16526 alongside carbamate."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18490']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/18489_R']/rh:contains1; rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:10750"", ""source_assertion"": ""RHEA:10750 consumes carbon dioxide CHEBI:16526 and water to regenerate bicarbonate."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10750']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/10748_R']/rh:contains1; rh:compound/rh:chebi""}, {""reference_id"": ""UniProtKB:P0ABE9"", ""source_assertion"": ""UniProt assigns CynT the apparent role of hydrating carbon dioxide formed during cyanase-dependent decomposition, limiting cellular bicarbonate depletion (ECO:0000269; PMID:1740425)."", ""source_locator"": ""comments[commentType='FUNCTION'].texts""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 10750 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:18490"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 18490 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0ABE9"", ""source_sha256"": ""30187217560b5439f03bc6d16210c8821d4ef168a35c81c78604bbeb3009b64a"", ""source_version"": ""2026_03; retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P0ABE9"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABE9.json""}]"	""
pathwaymech:MetaCyc_CYANCAT-PWY_cyanate-edge-026_e608ad954d8b	UniProtKB:P0ABE9	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ABE9		"[{""reference_id"": ""UniProtKB:P0ABE9"", ""source_assertion"": ""UniProt P0ABE9 carries GO:0005737 cytoplasm with IDA:EcoCyc and ECO:0000314 citing PMID:1740425."", ""source_locator"": ""uniProtKBCrossReferences[database='GO',id='GO:0005737'].properties and evidences""}]"	"[{""id"": ""UniProtKB:P0ABE9"", ""source_sha256"": ""30187217560b5439f03bc6d16210c8821d4ef168a35c81c78604bbeb3009b64a"", ""source_version"": ""2026_03; retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P0ABE9"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABE9.json""}]"	""
pathwaymech:MetaCyc_DARABCAT-PWY_edge-001_180bc621408c	CHEBI:17173	pathwaymech:consumes	RHEA:17602	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17602		"[{""reference_id"": ""RHEA:17602"", ""source_assertion"": ""Rhea lists CHEBI:17173 on the substrates side of RHEA:17602 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17602']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17602"", ""source_version"": ""139"", ""title"": ""Rhea D-ribulose-5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17602""}]"	""
pathwaymech:MetaCyc_DARABCAT-PWY_edge-002_43bba82eea75	CHEBI:30616	pathwaymech:consumes	RHEA:17602	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17602		"[{""reference_id"": ""RHEA:17602"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:17602 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17602']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17602"", ""source_version"": ""139"", ""title"": ""Rhea D-ribulose-5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17602""}]"	""
pathwaymech:MetaCyc_DARABCAT-PWY_edge-003_37a1b5803023	RHEA:17602	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17602		"[{""reference_id"": ""RHEA:17602"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:17602 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17602']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17602"", ""source_version"": ""139"", ""title"": ""Rhea D-ribulose-5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17602""}]"	""
pathwaymech:MetaCyc_DARABCAT-PWY_edge-004_da6b4e05f077	RHEA:17602	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17602		"[{""reference_id"": ""RHEA:17602"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:17602 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17602']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17602"", ""source_version"": ""139"", ""title"": ""Rhea D-ribulose-5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17602""}]"	""
pathwaymech:MetaCyc_DARABCAT-PWY_edge-005_d258fc870c02	RHEA:17602	pathwaymech:produces	CHEBI:58121	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17602		"[{""reference_id"": ""RHEA:17602"", ""source_assertion"": ""Rhea lists CHEBI:58121 on the products side of RHEA:17602 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17602']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17602"", ""source_version"": ""139"", ""title"": ""Rhea D-ribulose-5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17602""}]"	""
pathwaymech:MetaCyc_DARABCAT-PWY_edge-006_3b4bae3dc9c9	CHEBI:46994	pathwaymech:consumes	RHEA:13850	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13850		"[{""reference_id"": ""RHEA:13850"", ""source_assertion"": ""Rhea lists CHEBI:46994 on the substrates side of RHEA:13850 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13850']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13850"", ""source_version"": ""139"", ""title"": ""RHEA:13850 authority record"", ""url"": ""https://www.rhea-db.org/rhea/13850""}]"	""
pathwaymech:MetaCyc_DARABCAT-PWY_edge-007_8da87864a597	RHEA:13850	pathwaymech:produces	CHEBI:17173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13850		"[{""reference_id"": ""RHEA:13850"", ""source_assertion"": ""Rhea lists CHEBI:17173 on the products side of RHEA:13850 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13850']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13850"", ""source_version"": ""139"", ""title"": ""RHEA:13850 authority record"", ""url"": ""https://www.rhea-db.org/rhea/13850""}]"	""
pathwaymech:MetaCyc_DARABCAT-PWY_edge-008_1c8fbd06ca70	EC:5.3.1.3	pathwaymech:catalyzes	RHEA:13850	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13849		"[{""reference_id"": ""RHEA:13849"", ""source_assertion"": ""Rhea associates EC:5.3.1.3 with the reaction family containing RHEA:13850."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:13849"", ""source_version"": ""139"", ""title"": ""Rhea D-arabinose isomerase reaction"", ""url"": ""https://www.rhea-db.org/rhea/13849""}]"	""
pathwaymech:MetaCyc_DARABCAT-PWY_edge-009_83fc14eeb4d2	EC:2.7.1.47	pathwaymech:catalyzes	RHEA:17602	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17601		"[{""reference_id"": ""RHEA:17601"", ""source_assertion"": ""Rhea associates EC:2.7.1.47 with the reaction family containing RHEA:17602."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:17601"", ""source_version"": ""139"", ""title"": ""Rhea D-ribulokinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/17601""}]"	""
pathwaymech:MetaCyc_DARABCAT-PWY_edge-010_9999422dbc77	RHEA:13850	pathwaymech:precedes	RHEA:17602	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DARABCAT-PWY		"[{""reference_id"": ""MetaCyc:DARABCAT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:13850 before RHEA:17602 in this pathway. Shared intermediate: CHEBI:17173."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:DARABCAT-PWY"", ""source_sha256"": ""31141ce5e7b22affd71a8bd0e35245b223aa0dad6637420134609cd2d8ecd746"", ""source_version"": ""22.5"", ""title"": ""MetaCyc D-arabinose degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:DARABCAT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-001_c59a4fbfd96c	CHEBI:12931	pathwaymech:consumes	RHEA:18650	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18650		"[{""reference_id"": ""RHEA:18650"", ""source_assertion"": ""RHEA:18650 assigns CHEBI:12931 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/18650 rh:substrates http://rdf.rhea-db.org/18649_L; http://rdf.rhea-db.org/18649_L rh:contains1 http://rdf.rhea-db.org/Participant_18649_compound_4453; http://rdf.rhea-db.org/Participant_18649_compound_4453 rh:compound http://rdf.rhea-db.org/Compound_4453; http://rdf.rhea-db.org/Compound_4453 rh:chebi http://purl.obolibrary.org/obo/CHEBI_12931""}]"	"[{""id"": ""RHEA:18650"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF"", ""title"": ""D-galactonate => 2-dehydro-3-deoxy-D-galactonate + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-002_4b896e829145	RHEA:18650	pathwaymech:produces	CHEBI:57989	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18650		"[{""reference_id"": ""RHEA:18650"", ""source_assertion"": ""RHEA:18650 assigns CHEBI:57989 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/18650 rh:products http://rdf.rhea-db.org/18649_R; http://rdf.rhea-db.org/18649_R rh:contains1 http://rdf.rhea-db.org/Participant_18649_compound_2839; http://rdf.rhea-db.org/Participant_18649_compound_2839 rh:compound http://rdf.rhea-db.org/Compound_2839; http://rdf.rhea-db.org/Compound_2839 rh:chebi http://purl.obolibrary.org/obo/CHEBI_57989""}]"	"[{""id"": ""RHEA:18650"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF"", ""title"": ""D-galactonate => 2-dehydro-3-deoxy-D-galactonate + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-003_33fa2971ee17	RHEA:18650	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18650		"[{""reference_id"": ""RHEA:18650"", ""source_assertion"": ""RHEA:18650 assigns CHEBI:15377 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/18650 rh:products http://rdf.rhea-db.org/18649_R; http://rdf.rhea-db.org/18649_R rh:contains1 http://rdf.rhea-db.org/Participant_18649_compound_1283; http://rdf.rhea-db.org/Participant_18649_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; http://rdf.rhea-db.org/Compound_1283 rh:chebi http://purl.obolibrary.org/obo/CHEBI_15377""}]"	"[{""id"": ""RHEA:18650"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF"", ""title"": ""D-galactonate => 2-dehydro-3-deoxy-D-galactonate + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-004_9856dd46d101	CHEBI:57989	pathwaymech:consumes	RHEA:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16526		"[{""reference_id"": ""RHEA:16526"", ""source_assertion"": ""RHEA:16526 assigns CHEBI:57989 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/16526 rh:substrates http://rdf.rhea-db.org/16525_L; http://rdf.rhea-db.org/16525_L rh:contains1 http://rdf.rhea-db.org/Participant_16525_compound_2839; http://rdf.rhea-db.org/Participant_16525_compound_2839 rh:compound http://rdf.rhea-db.org/Compound_2839; http://rdf.rhea-db.org/Compound_2839 rh:chebi http://purl.obolibrary.org/obo/CHEBI_57989""}]"	"[{""id"": ""RHEA:16526"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF"", ""title"": ""2-dehydro-3-deoxy-D-galactonate + ATP => 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-005_1e6eb43b1c74	CHEBI:30616	pathwaymech:consumes	RHEA:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16526		"[{""reference_id"": ""RHEA:16526"", ""source_assertion"": ""RHEA:16526 assigns CHEBI:30616 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/16526 rh:substrates http://rdf.rhea-db.org/16525_L; http://rdf.rhea-db.org/16525_L rh:contains1 http://rdf.rhea-db.org/Participant_16525_compound_6372; http://rdf.rhea-db.org/Participant_16525_compound_6372 rh:compound http://rdf.rhea-db.org/Compound_6372; http://rdf.rhea-db.org/Compound_6372 rh:chebi http://purl.obolibrary.org/obo/CHEBI_30616""}]"	"[{""id"": ""RHEA:16526"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF"", ""title"": ""2-dehydro-3-deoxy-D-galactonate + ATP => 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-006_5fafba7af491	RHEA:16526	pathwaymech:produces	CHEBI:58298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16526		"[{""reference_id"": ""RHEA:16526"", ""source_assertion"": ""RHEA:16526 assigns CHEBI:58298 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/16526 rh:products http://rdf.rhea-db.org/16525_R; http://rdf.rhea-db.org/16525_R rh:contains1 http://rdf.rhea-db.org/Participant_16525_compound_3333; http://rdf.rhea-db.org/Participant_16525_compound_3333 rh:compound http://rdf.rhea-db.org/Compound_3333; http://rdf.rhea-db.org/Compound_3333 rh:chebi http://purl.obolibrary.org/obo/CHEBI_58298""}]"	"[{""id"": ""RHEA:16526"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF"", ""title"": ""2-dehydro-3-deoxy-D-galactonate + ATP => 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-007_405a4d1fbc41	RHEA:16526	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16526		"[{""reference_id"": ""RHEA:16526"", ""source_assertion"": ""RHEA:16526 assigns CHEBI:456216 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/16526 rh:products http://rdf.rhea-db.org/16525_R; http://rdf.rhea-db.org/16525_R rh:contains1 http://rdf.rhea-db.org/Participant_16525_compound_2710; http://rdf.rhea-db.org/Participant_16525_compound_2710 rh:compound http://rdf.rhea-db.org/Compound_2710; http://rdf.rhea-db.org/Compound_2710 rh:chebi http://purl.obolibrary.org/obo/CHEBI_456216""}]"	"[{""id"": ""RHEA:16526"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF"", ""title"": ""2-dehydro-3-deoxy-D-galactonate + ATP => 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-008_aaa21d24cf22	RHEA:16526	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16526		"[{""reference_id"": ""RHEA:16526"", ""source_assertion"": ""RHEA:16526 assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/16526 rh:products http://rdf.rhea-db.org/16525_R; http://rdf.rhea-db.org/16525_R rh:contains1 http://rdf.rhea-db.org/Participant_16525_compound_3249; http://rdf.rhea-db.org/Participant_16525_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; http://rdf.rhea-db.org/Compound_3249 rh:chebi http://purl.obolibrary.org/obo/CHEBI_15378""}]"	"[{""id"": ""RHEA:16526"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF"", ""title"": ""2-dehydro-3-deoxy-D-galactonate + ATP => 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-009_183a8d32c994	CHEBI:58298	pathwaymech:consumes	RHEA:24465	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24465		"[{""reference_id"": ""RHEA:24465"", ""source_assertion"": ""RHEA:24465 assigns CHEBI:58298 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/24465 rh:substrates http://rdf.rhea-db.org/24464_L; http://rdf.rhea-db.org/24464_L rh:contains1 http://rdf.rhea-db.org/Participant_24464_compound_3333; http://rdf.rhea-db.org/Participant_24464_compound_3333 rh:compound http://rdf.rhea-db.org/Compound_3333; http://rdf.rhea-db.org/Compound_3333 rh:chebi http://purl.obolibrary.org/obo/CHEBI_58298""}]"	"[{""id"": ""RHEA:24465"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF"", ""title"": ""2-dehydro-3-deoxy-6-phospho-D-galactonate => D-glyceraldehyde 3-phosphate + pyruvate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-010_fcb41d23cf67	RHEA:24465	pathwaymech:produces	CHEBI:59776	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24465		"[{""reference_id"": ""RHEA:24465"", ""source_assertion"": ""RHEA:24465 assigns CHEBI:59776 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/24465 rh:products http://rdf.rhea-db.org/24464_R; http://rdf.rhea-db.org/24464_R rh:contains1 http://rdf.rhea-db.org/Participant_24464_compound_6062; http://rdf.rhea-db.org/Participant_24464_compound_6062 rh:compound http://rdf.rhea-db.org/Compound_6062; http://rdf.rhea-db.org/Compound_6062 rh:chebi http://purl.obolibrary.org/obo/CHEBI_59776""}]"	"[{""id"": ""RHEA:24465"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF"", ""title"": ""2-dehydro-3-deoxy-6-phospho-D-galactonate => D-glyceraldehyde 3-phosphate + pyruvate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-011_45c4dc5b30d0	RHEA:24465	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24465		"[{""reference_id"": ""RHEA:24465"", ""source_assertion"": ""RHEA:24465 assigns CHEBI:15361 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/24465 rh:products http://rdf.rhea-db.org/24464_R; http://rdf.rhea-db.org/24464_R rh:contains1 http://rdf.rhea-db.org/Participant_24464_compound_3719; http://rdf.rhea-db.org/Participant_24464_compound_3719 rh:compound http://rdf.rhea-db.org/Compound_3719; http://rdf.rhea-db.org/Compound_3719 rh:chebi http://purl.obolibrary.org/obo/CHEBI_15361""}]"	"[{""id"": ""RHEA:24465"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF"", ""title"": ""2-dehydro-3-deoxy-6-phospho-D-galactonate => D-glyceraldehyde 3-phosphate + pyruvate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-012_9512a1ecf248	UniProtKB:Q6BF17	pathwaymech:enables	RHEA:18650	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GALACTONATE-DEHYDRATASE-MONOMER|UniProtKB:Q6BF17	Functional enzyme assignment; no physical assembly stoichiometry is asserted.	"[{""reference_id"": ""UniProtKB:Q6BF17"", ""source_assertion"": ""The reviewed Q6BF17 catalytic-activity annotation assigns RHEA:18649; this specifies the gene product function, not isolated-monomer sufficiency."", ""source_locator"": ""comments[1].reaction.name/reactionCrossReferences; organism.taxonId; genes""}, {""reference_id"": ""MetaCyc:GALACTONATE-DEHYDRATASE-MONOMER"", ""source_assertion"": ""The native MG1655 protein frame identifies UniProt Q6BF17 and links its enzymatic reaction to GALACTONDEHYDRAT-RXN."", ""source_locator"": ""Protein[@frameid=\""GALACTONATE-DEHYDRATASE-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]; species/Organism[@frameid=\""TAX-511145\""]; catalyzes/Enzymatic-Reaction/reaction/Reaction""}]"	"[{""id"": ""MetaCyc:GALACTONATE-DEHYDRATASE-MONOMER"", ""source_sha256"": ""863e1d8098a4749df32fd829f7135a847a109083d8d8b38463747ad38c548efe"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native GALACTONATE-DEHYDRATASE-MONOMER definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GALACTONATE-DEHYDRATASE-MONOMER""}, {""id"": ""UniProtKB:Q6BF17"", ""source_sha256"": ""77084e43c46dcd45816a3bd2c425e885c8b4687f9048d8517721be4359ddf60f"", ""source_version"": ""UniProt 2026_03; complete JSON retrieved 2026-10-11 UTC; release confirmed by response header"", ""title"": ""Reviewed E. coli K-12 D-galactonate dehydratase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q6BF17.json""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-013_cd626f1cb5e9	UniProtKB:P31459	pathwaymech:enables	RHEA:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEHYDDEOXGALACTKIN-MONOMER|UniProtKB:P31459	Functional enzyme assignment; no physical assembly stoichiometry is asserted.	"[{""reference_id"": ""UniProtKB:P31459"", ""source_assertion"": ""The reviewed P31459 catalytic-activity annotation assigns RHEA:16525; this specifies the gene product function, not isolated-monomer sufficiency."", ""source_locator"": ""comments[0].reaction.name/reactionCrossReferences; organism.taxonId; genes""}, {""reference_id"": ""MetaCyc:DEHYDDEOXGALACTKIN-MONOMER"", ""source_assertion"": ""The native MG1655 protein frame identifies UniProt P31459 and links its enzymatic reaction to DEHYDDEOXGALACTKIN-RXN."", ""source_locator"": ""Protein[@frameid=\""DEHYDDEOXGALACTKIN-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]; species/Organism[@frameid=\""TAX-511145\""]; catalyzes/Enzymatic-Reaction/reaction/Reaction""}]"	"[{""id"": ""MetaCyc:DEHYDDEOXGALACTKIN-MONOMER"", ""source_sha256"": ""6327b7ece79efa26915821049ca9c52aa6afb6729c1ac44635d61032525803b1"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native DEHYDDEOXGALACTKIN-MONOMER definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEHYDDEOXGALACTKIN-MONOMER""}, {""id"": ""UniProtKB:P31459"", ""source_sha256"": ""b770b4613dcf98e6aa24952569ec4c7acb0c922f4aa1ccba28c163edf80aeaac"", ""source_version"": ""UniProt 2026_03; complete JSON retrieved 2026-10-11 UTC; release confirmed by response header"", ""title"": ""Reviewed E. coli K-12 2-dehydro-3-deoxygalactonokinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31459.json""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-014_416c27d5dca9	UniProtKB:Q6BF16	pathwaymech:enables	RHEA:24465	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-MONOMER|PMID:17981470|UniProtKB:Q6BF16	Functional enzyme assignment; the active protein is described as a homotrimer, without a separately identified physical-complex node.	"[{""reference_id"": ""UniProtKB:Q6BF16"", ""source_assertion"": ""The reviewed Q6BF16 catalytic-activity annotation assigns RHEA:24464; this specifies the gene product function, not isolated-monomer sufficiency."", ""source_locator"": ""comments[1].reaction.name/reactionCrossReferences; organism.taxonId; genes""}, {""reference_id"": ""MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-MONOMER"", ""source_assertion"": ""The native MG1655 protein frame identifies UniProt Q6BF16 and links its enzymatic reaction to DEHYDDEOXPHOSGALACT-ALDOL-RXN."", ""source_locator"": ""Protein[@frameid=\""DEHYDDEOXPHOSGALACT-ALDOL-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]; species/Organism[@frameid=\""TAX-511145\""]; catalyzes/Enzymatic-Reaction/reaction/Reaction""}, {""reference_id"": ""PMID:17981470"", ""source_assertion"": ""Purified recombinant E. coli KDPGal aldolase cleaved KDPGal; the structure and solution description support a homotrimer. Expression in an eda-deficient host reduced KDPG-aldolase contamination."", ""source_locator"": ""PMC3326530 Results #P5, #P6 and #P10; Introduction #P4; Methods #P22-#P25 and #P33""}]"	"[{""id"": ""MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-MONOMER"", ""source_sha256"": ""364880432fd4868c17c91bba9a60af4729aeceffd220f3b56282202403812781"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native DEHYDDEOXPHOSGALACT-ALDOL-MONOMER definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEHYDDEOXPHOSGALACT-ALDOL-MONOMER""}, {""id"": ""PMID:17981470"", ""source_sha256"": ""58a7e34b46e22091c33481f273f62c2606844ccd703cb5122fb11c72f7d783e1"", ""source_version"": ""Complete primary HTML; inspected Results and Methods; retrieved 2026-10-11 UTC"", ""title"": ""Characterization and crystal structure of Escherichia coli KDPGal aldolase."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3326530/""}, {""id"": ""UniProtKB:Q6BF16"", ""source_sha256"": ""9f0d514e7167c0d7fe0e393b7fdcc45b013cf53a2ea8dd1cad5e60168ab17cc6"", ""source_version"": ""UniProt 2026_03; complete JSON retrieved 2026-10-11 UTC; release confirmed by response header"", ""title"": ""Reviewed E. coli K-12 2-dehydro-3-deoxy-6-phosphogalactonate aldolase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q6BF16.json""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-015_84e6141ea95e	RHEA:18650	BFO:0000050	MetaCyc:GALACTCAT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GALACTCAT-PWY|MetaCyc:GALACTONDEHYDRAT-RXN|RHEA:18650		"[{""reference_id"": ""MetaCyc:GALACTCAT-PWY"", ""source_assertion"": ""The complete native pathway includes GALACTONDEHYDRAT-RXN in its reaction list and selects L2R in its pathway layout."", ""source_locator"": ""Pathway[@frameid=\""GALACTCAT-PWY\""]/reaction-list/Reaction[@frameid=\""GALACTONDEHYDRAT-RXN\""]; reaction-layout[Reaction/@frameid=\""GALACTONDEHYDRAT-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:GALACTONDEHYDRAT-RXN"", ""source_assertion"": ""The native reaction cross-references RHEA:18650; its reaction-direction is LEFT-TO-RIGHT."", ""source_locator"": ""Reaction/dblink[dblink-db=\""RHEA\""]; reaction-direction; left/Compound; right/Compound""}, {""reference_id"": ""RHEA:18650"", ""source_assertion"": ""Rhea master 18649 explicitly contains directed member 18650; the selected substrates and products implement catabolic left-to-right chemistry."", ""source_locator"": ""http://rdf.rhea-db.org/18649 rh:directionalReaction http://rdf.rhea-db.org/18650; http://rdf.rhea-db.org/18650 rh:substrates http://rdf.rhea-db.org/18649_L; rh:products http://rdf.rhea-db.org/18649_R; rh:equation""}]"	"[{""id"": ""MetaCyc:GALACTCAT-PWY"", ""source_sha256"": ""fd37229b22a120444fec0df7b4cc41b13b2b7517cae07b628a0538789c6ad20f"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""D-galactonate degradation: complete native pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GALACTCAT-PWY""}, {""id"": ""MetaCyc:GALACTONDEHYDRAT-RXN"", ""source_sha256"": ""7a9f7ce85da89aadffa5a41fdfc00c25fe954cecf307bfb81642939abbc5e375"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native GALACTONDEHYDRAT-RXN definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GALACTONDEHYDRAT-RXN""}, {""id"": ""RHEA:18650"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF"", ""title"": ""D-galactonate => 2-dehydro-3-deoxy-D-galactonate + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-016_703dbfd59829	RHEA:16526	BFO:0000050	MetaCyc:GALACTCAT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEHYDDEOXGALACTKIN-RXN|MetaCyc:GALACTCAT-PWY|RHEA:16526		"[{""reference_id"": ""MetaCyc:GALACTCAT-PWY"", ""source_assertion"": ""The complete native pathway includes DEHYDDEOXGALACTKIN-RXN in its reaction list and selects L2R in its pathway layout."", ""source_locator"": ""Pathway[@frameid=\""GALACTCAT-PWY\""]/reaction-list/Reaction[@frameid=\""DEHYDDEOXGALACTKIN-RXN\""]; reaction-layout[Reaction/@frameid=\""DEHYDDEOXGALACTKIN-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:DEHYDDEOXGALACTKIN-RXN"", ""source_assertion"": ""The native reaction cross-references RHEA:16526; its reaction-direction is LEFT-TO-RIGHT."", ""source_locator"": ""Reaction/dblink[dblink-db=\""RHEA\""]; reaction-direction; left/Compound; right/Compound""}, {""reference_id"": ""RHEA:16526"", ""source_assertion"": ""Rhea master 16525 explicitly contains directed member 16526; the selected substrates and products implement catabolic left-to-right chemistry."", ""source_locator"": ""http://rdf.rhea-db.org/16525 rh:directionalReaction http://rdf.rhea-db.org/16526; http://rdf.rhea-db.org/16526 rh:substrates http://rdf.rhea-db.org/16525_L; rh:products http://rdf.rhea-db.org/16525_R; rh:equation""}]"	"[{""id"": ""MetaCyc:DEHYDDEOXGALACTKIN-RXN"", ""source_sha256"": ""0b306ee63e5498a9ace9423d4eb89c23a8906e5b51741529cb6caab0b468e57a"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native DEHYDDEOXGALACTKIN-RXN definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEHYDDEOXGALACTKIN-RXN""}, {""id"": ""MetaCyc:GALACTCAT-PWY"", ""source_sha256"": ""fd37229b22a120444fec0df7b4cc41b13b2b7517cae07b628a0538789c6ad20f"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""D-galactonate degradation: complete native pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GALACTCAT-PWY""}, {""id"": ""RHEA:16526"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF"", ""title"": ""2-dehydro-3-deoxy-D-galactonate + ATP => 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-017_37d751f58d30	RHEA:24465	BFO:0000050	MetaCyc:GALACTCAT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-RXN|MetaCyc:GALACTCAT-PWY|RHEA:24465		"[{""reference_id"": ""MetaCyc:GALACTCAT-PWY"", ""source_assertion"": ""The complete native pathway includes DEHYDDEOXPHOSGALACT-ALDOL-RXN in its reaction list and selects L2R in its pathway layout."", ""source_locator"": ""Pathway[@frameid=\""GALACTCAT-PWY\""]/reaction-list/Reaction[@frameid=\""DEHYDDEOXPHOSGALACT-ALDOL-RXN\""]; reaction-layout[Reaction/@frameid=\""DEHYDDEOXPHOSGALACT-ALDOL-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-RXN"", ""source_assertion"": ""The native reaction cross-references RHEA:24467; its reaction-direction is REVERSIBLE."", ""source_locator"": ""Reaction/dblink[dblink-db=\""RHEA\""]; reaction-direction; left/Compound; right/Compound""}, {""reference_id"": ""RHEA:24465"", ""source_assertion"": ""Rhea master 24464 explicitly contains directed member 24465; the selected substrates and products implement catabolic left-to-right chemistry."", ""source_locator"": ""http://rdf.rhea-db.org/24464 rh:directionalReaction http://rdf.rhea-db.org/24465; http://rdf.rhea-db.org/24465 rh:substrates http://rdf.rhea-db.org/24464_L; rh:products http://rdf.rhea-db.org/24464_R; rh:equation""}]"	"[{""id"": ""MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-RXN"", ""source_sha256"": ""c66e4fbab0476b5db784885e71babe25624df7739d2f0fcd7ee901db27b40cc8"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native DEHYDDEOXPHOSGALACT-ALDOL-RXN definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEHYDDEOXPHOSGALACT-ALDOL-RXN""}, {""id"": ""MetaCyc:GALACTCAT-PWY"", ""source_sha256"": ""fd37229b22a120444fec0df7b4cc41b13b2b7517cae07b628a0538789c6ad20f"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""D-galactonate degradation: complete native pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GALACTCAT-PWY""}, {""id"": ""RHEA:24465"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF"", ""title"": ""2-dehydro-3-deoxy-6-phospho-D-galactonate => D-glyceraldehyde 3-phosphate + pyruvate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-018_d32b1d0196e7	UniProtKB:Q6BF17	BFO:0000050	NCBITaxon:83333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q6BF17		"[{""reference_id"": ""UniProtKB:Q6BF17"", ""source_assertion"": ""The reviewed Q6BF17 entry assigns the protein to Escherichia coli strain K12, taxon 83333."", ""source_locator"": ""organism.scientificName; organism.taxonId; genes""}]"	"[{""id"": ""UniProtKB:Q6BF17"", ""source_sha256"": ""77084e43c46dcd45816a3bd2c425e885c8b4687f9048d8517721be4359ddf60f"", ""source_version"": ""UniProt 2026_03; complete JSON retrieved 2026-10-11 UTC; release confirmed by response header"", ""title"": ""Reviewed E. coli K-12 D-galactonate dehydratase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q6BF17.json""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-019_9a0e4a082144	UniProtKB:P31459	BFO:0000050	NCBITaxon:83333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31459		"[{""reference_id"": ""UniProtKB:P31459"", ""source_assertion"": ""The reviewed P31459 entry assigns the protein to Escherichia coli strain K12, taxon 83333."", ""source_locator"": ""organism.scientificName; organism.taxonId; genes""}]"	"[{""id"": ""UniProtKB:P31459"", ""source_sha256"": ""b770b4613dcf98e6aa24952569ec4c7acb0c922f4aa1ccba28c163edf80aeaac"", ""source_version"": ""UniProt 2026_03; complete JSON retrieved 2026-10-11 UTC; release confirmed by response header"", ""title"": ""Reviewed E. coli K-12 2-dehydro-3-deoxygalactonokinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31459.json""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-020_103376bcb06b	UniProtKB:Q6BF16	BFO:0000050	NCBITaxon:83333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q6BF16		"[{""reference_id"": ""UniProtKB:Q6BF16"", ""source_assertion"": ""The reviewed Q6BF16 entry assigns the protein to Escherichia coli strain K12, taxon 83333."", ""source_locator"": ""organism.scientificName; organism.taxonId; genes""}]"	"[{""id"": ""UniProtKB:Q6BF16"", ""source_sha256"": ""9f0d514e7167c0d7fe0e393b7fdcc45b013cf53a2ea8dd1cad5e60168ab17cc6"", ""source_version"": ""UniProt 2026_03; complete JSON retrieved 2026-10-11 UTC; release confirmed by response header"", ""title"": ""Reviewed E. coli K-12 2-dehydro-3-deoxy-6-phosphogalactonate aldolase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q6BF16.json""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-021_9fa221286cc8	UniProtKB:P31460	BFO:0000050	NCBITaxon:83333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31460		"[{""reference_id"": ""UniProtKB:P31460"", ""source_assertion"": ""The reviewed P31460 entry assigns the protein to Escherichia coli strain K12, taxon 83333."", ""source_locator"": ""organism.scientificName; organism.taxonId; genes""}]"	"[{""id"": ""UniProtKB:P31460"", ""source_sha256"": ""ea07011665016cfabcd538e0faa80b7adeddcbac8659ae3c45ada60f502c38a8"", ""source_version"": ""UniProt 2026_03; complete JSON retrieved 2026-10-11 UTC; release confirmed by response header"", ""title"": ""Reviewed E. coli K-12 Galactonate operon transcriptional repressor"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31460.json""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-022_b5eb1084fe32	UniProtKB:Q6BF17	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q6BF17	Magnesium assignment by similarity; no physical oligomer stoichiometry inferred.	"[{""reference_id"": ""UniProtKB:Q6BF17"", ""source_assertion"": ""DgoD is annotated to bind one Mg(2+) per subunit by similarity (ECO:0000250); this is not a direct K-12 metal-binding measurement."", ""source_locator"": ""comments[2].cofactors[0].cofactorCrossReference/evidences; comments[2].note.texts[0]""}]"	"[{""id"": ""UniProtKB:Q6BF17"", ""source_sha256"": ""77084e43c46dcd45816a3bd2c425e885c8b4687f9048d8517721be4359ddf60f"", ""source_version"": ""UniProt 2026_03; complete JSON retrieved 2026-10-11 UTC; release confirmed by response header"", ""title"": ""Reviewed E. coli K-12 D-galactonate dehydratase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q6BF17.json""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-023_429a862a04a0	RHEA:18650	pathwaymech:precedes	RHEA:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GALACTCAT-PWY|RHEA:16526|RHEA:18650		"[{""reference_id"": ""MetaCyc:GALACTCAT-PWY"", ""source_assertion"": ""Native pathway ordering places GALACTONDEHYDRAT-RXN before DEHYDDEOXGALACTKIN-RXN."", ""source_locator"": ""Pathway/reaction-ordering[Reaction/@frameid=\""DEHYDDEOXGALACTKIN-RXN\""]/predecessor-reactions/Reaction[@frameid=\""GALACTONDEHYDRAT-RXN\""]""}, {""reference_id"": ""RHEA:18650"", ""source_assertion"": ""In the selected Rhea chemistry the preceding reaction produces the retained shared intermediate CHEBI:57989."", ""source_locator"": ""http://rdf.rhea-db.org/18650 rh:products http://rdf.rhea-db.org/18649_R; side rh:contains1 / participant rh:compound / compound rh:chebi""}, {""reference_id"": ""RHEA:16526"", ""source_assertion"": ""The subsequent selected Rhea reaction consumes CHEBI:57989, connecting the native steps without adding a transport reaction."", ""source_locator"": ""http://rdf.rhea-db.org/16526 rh:substrates http://rdf.rhea-db.org/16525_L; side rh:contains1 / participant rh:compound / compound rh:chebi""}]"	"[{""id"": ""MetaCyc:GALACTCAT-PWY"", ""source_sha256"": ""fd37229b22a120444fec0df7b4cc41b13b2b7517cae07b628a0538789c6ad20f"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""D-galactonate degradation: complete native pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GALACTCAT-PWY""}, {""id"": ""RHEA:16526"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF"", ""title"": ""2-dehydro-3-deoxy-D-galactonate + ATP => 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:18650"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF"", ""title"": ""D-galactonate => 2-dehydro-3-deoxy-D-galactonate + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-024_20dc3ccff58a	RHEA:16526	pathwaymech:precedes	RHEA:24465	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GALACTCAT-PWY|RHEA:16526|RHEA:24465		"[{""reference_id"": ""MetaCyc:GALACTCAT-PWY"", ""source_assertion"": ""Native pathway ordering places DEHYDDEOXGALACTKIN-RXN before DEHYDDEOXPHOSGALACT-ALDOL-RXN."", ""source_locator"": ""Pathway/reaction-ordering[Reaction/@frameid=\""DEHYDDEOXPHOSGALACT-ALDOL-RXN\""]/predecessor-reactions/Reaction[@frameid=\""DEHYDDEOXGALACTKIN-RXN\""]""}, {""reference_id"": ""RHEA:16526"", ""source_assertion"": ""In the selected Rhea chemistry the preceding reaction produces the retained shared intermediate CHEBI:58298."", ""source_locator"": ""http://rdf.rhea-db.org/16526 rh:products http://rdf.rhea-db.org/16525_R; side rh:contains1 / participant rh:compound / compound rh:chebi""}, {""reference_id"": ""RHEA:24465"", ""source_assertion"": ""The subsequent selected Rhea reaction consumes CHEBI:58298, connecting the native steps without adding a transport reaction."", ""source_locator"": ""http://rdf.rhea-db.org/24465 rh:substrates http://rdf.rhea-db.org/24464_L; side rh:contains1 / participant rh:compound / compound rh:chebi""}]"	"[{""id"": ""MetaCyc:GALACTCAT-PWY"", ""source_sha256"": ""fd37229b22a120444fec0df7b4cc41b13b2b7517cae07b628a0538789c6ad20f"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""D-galactonate degradation: complete native pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GALACTCAT-PWY""}, {""id"": ""RHEA:16526"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF"", ""title"": ""2-dehydro-3-deoxy-D-galactonate + ATP => 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:24465"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF"", ""title"": ""2-dehydro-3-deoxy-6-phospho-D-galactonate => D-glyceraldehyde 3-phosphate + pyruvate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-025_f2953e10fc5e	MetaCyc:GALACTCAT-PWY	BFO:0000050	NCBITaxon:83333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:211976|PMID:30455279		"[{""reference_id"": ""PMID:30455279"", ""source_assertion"": ""BW25113-derived dgoD, dgoK and dgoA deletions failed to grow on D-galactonate while growing on glucose. These genetic results support K-12 pathway physiology, not purified-enzyme assignments."", ""source_locator"": ""PMC6351737 Results #s2.1, Fig. 1C; Materials and Methods #s4.3, Table 1""}, {""reference_id"": ""PMID:211976"", ""source_assertion"": ""The publisher abstract reports K-12 mutants lacking individual D-galactonate pathway activities or all three, with linked structural genes and inducible enzyme activities."", ""source_locator"": ""Publisher Abstract, numbered statements 1, 2 and 6; abstract-only access""}]"	"[{""id"": ""PMID:211976"", ""source_sha256"": ""64570c405c388eba927e697a30f097bfcc2d8892e0deb96bf50d613008cbde6a"", ""source_version"": ""Publisher abstract only; numbered statements 1-6 inspected; full article unavailable; retrieved 2026-10-11 UTC"", ""title"": ""The utilisation of D-galactonate and D-2-oxo-3-deoxygalactonate by Escherichia coli K-12."", ""url"": ""https://link.springer.com/article/10.1007/BF00415730""}, {""id"": ""PMID:30455279"", ""source_sha256"": ""1bab347e98dafa6dfb04253e6b080cad78cff4b2c6139a1b77e6ff29509fec07"", ""source_version"": ""Complete primary HTML; inspected Results and Methods; retrieved 2026-10-11 UTC"", ""title"": ""Molecular and Functional Insights into the Regulation of D-Galactonate Metabolism by the Transcriptional Regulator DgoR in Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC6351737/""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-026_3e148a55732b	UniProtKB:P31460	pathwaymech:regulates	MetaCyc:GALACTCAT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:30455279|UniProtKB:P31460	Negative transcriptional regulation of the operon encoding the pathway, not direct inhibition of catalytic proteins.	"[{""reference_id"": ""UniProtKB:P31460"", ""source_assertion"": ""Reviewed DgoR annotation describes repression of the dgoRKADT operon through binding two inverted repeats in its cis-acting element."", ""source_locator"": ""comments[0] FUNCTION""}, {""reference_id"": ""PMID:30455279"", ""source_assertion"": ""DgoR loss increased dgo transcription; purified DgoR bound the upstream cis-acting element, with IR1 and IR2 needed for binding and repression."", ""source_locator"": ""PMC6351737 Results #s2.1 and #s2.4; Fig. 1F and Fig. 4; Methods #s4.3 and #s4.9""}]"	"[{""id"": ""PMID:30455279"", ""source_sha256"": ""1bab347e98dafa6dfb04253e6b080cad78cff4b2c6139a1b77e6ff29509fec07"", ""source_version"": ""Complete primary HTML; inspected Results and Methods; retrieved 2026-10-11 UTC"", ""title"": ""Molecular and Functional Insights into the Regulation of D-Galactonate Metabolism by the Transcriptional Regulator DgoR in Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC6351737/""}, {""id"": ""UniProtKB:P31460"", ""source_sha256"": ""ea07011665016cfabcd538e0faa80b7adeddcbac8659ae3c45ada60f502c38a8"", ""source_version"": ""UniProt 2026_03; complete JSON retrieved 2026-10-11 UTC; release confirmed by response header"", ""title"": ""Reviewed E. coli K-12 Galactonate operon transcriptional repressor"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31460.json""}]"	""
pathwaymech:MetaCyc_GALACTCAT-PWY_galactonate-edge-027_2b8e9e9fba9e	CHEBI:12931	pathwaymech:inhibits	UniProtKB:P31460	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:30455279|PMID:33224125	Inhibition of repressor DNA binding under the tested conditions; divalent-metal-dependent effector response, without assigning a unique physiological metal or catalytic consumption of the effector.	"[{""reference_id"": ""PMID:30455279"", ""source_assertion"": ""D-galactonate reduced DgoR binding to its target DNA in vitro and changed its proteolysis pattern; the EMSA buffer contained MgCl2."", ""source_locator"": ""PMC6351737 Results #s2.7, Fig. 8A-C; Materials and Methods #s4.9 and #s4.12""}, {""reference_id"": ""PMID:33224125"", ""source_assertion"": ""After EDTA treatment, D-galactonate with Zn2+, Ca2+ or Mg2+ reduced DgoR-DNA complex stability. Metal depletion did not directly abolish DNA binding."", ""source_locator"": ""PMC7674646 Results #S3.SS3, Fig. 6; Discussion #S4""}]"	"[{""id"": ""PMID:30455279"", ""source_sha256"": ""1bab347e98dafa6dfb04253e6b080cad78cff4b2c6139a1b77e6ff29509fec07"", ""source_version"": ""Complete primary HTML; inspected Results and Methods; retrieved 2026-10-11 UTC"", ""title"": ""Molecular and Functional Insights into the Regulation of D-Galactonate Metabolism by the Transcriptional Regulator DgoR in Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC6351737/""}, {""id"": ""PMID:33224125"", ""source_sha256"": ""2a6d1a7b8712676db20544de7dc6f85fc1e45159730ae429d811664489f0ade5"", ""source_version"": ""Complete primary HTML; inspected Results and Methods; retrieved 2026-10-11 UTC"", ""title"": ""Structural and Functional Analyses of the Transcription Repressor DgoR From Escherichia coli Reveal a Divalent Metal-Containing D-Galactonate Binding Pocket."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC7674646/""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-001_590155e0de93	CHEBI:17360	pathwaymech:consumes	RHEA:15958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15958		"[{""reference_id"": ""RHEA:15958"", ""source_assertion"": ""Rhea lists CHEBI:17360 on the substrates side of RHEA:15958 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15958']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15958"", ""source_version"": ""139"", ""title"": ""Rhea altronate-dehydrating direction"", ""url"": ""https://www.rhea-db.org/rhea/15958""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-002_3eadf67b5c5e	RHEA:15958	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15958		"[{""reference_id"": ""RHEA:15958"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:15958 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15958']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15958"", ""source_version"": ""139"", ""title"": ""Rhea altronate-dehydrating direction"", ""url"": ""https://www.rhea-db.org/rhea/15958""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-003_2f64edd5bd2a	RHEA:15958	pathwaymech:produces	CHEBI:57990	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15958		"[{""reference_id"": ""RHEA:15958"", ""source_assertion"": ""Rhea lists CHEBI:57990 on the products side of RHEA:15958 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15958']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15958"", ""source_version"": ""139"", ""title"": ""Rhea altronate-dehydrating direction"", ""url"": ""https://www.rhea-db.org/rhea/15958""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-004_5e96abd1d458	CHEBI:30616	pathwaymech:consumes	RHEA:14798	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14798		"[{""reference_id"": ""RHEA:14798"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:14798 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14798']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14798"", ""source_version"": ""139"", ""title"": ""Rhea 2-dehydro-3-deoxy-6-phospho-D-gluconate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14798""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-005_ecb786ffa79b	CHEBI:57990	pathwaymech:consumes	RHEA:14798	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14798		"[{""reference_id"": ""RHEA:14798"", ""source_assertion"": ""Rhea lists CHEBI:57990 on the substrates side of RHEA:14798 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14798']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14798"", ""source_version"": ""139"", ""title"": ""Rhea 2-dehydro-3-deoxy-6-phospho-D-gluconate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14798""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-006_21c58b309337	RHEA:14798	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14798		"[{""reference_id"": ""RHEA:14798"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:14798 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14798']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14798"", ""source_version"": ""139"", ""title"": ""Rhea 2-dehydro-3-deoxy-6-phospho-D-gluconate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14798""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-007_513a48339f0b	RHEA:14798	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14798		"[{""reference_id"": ""RHEA:14798"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:14798 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14798']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14798"", ""source_version"": ""139"", ""title"": ""Rhea 2-dehydro-3-deoxy-6-phospho-D-gluconate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14798""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-008_596ed49c0e32	RHEA:14798	pathwaymech:produces	CHEBI:57569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14798		"[{""reference_id"": ""RHEA:14798"", ""source_assertion"": ""Rhea lists CHEBI:57569 on the products side of RHEA:14798 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14798']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14798"", ""source_version"": ""139"", ""title"": ""Rhea 2-dehydro-3-deoxy-6-phospho-D-gluconate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14798""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-009_5ae14db845b4	CHEBI:57569	pathwaymech:consumes	RHEA:17090	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17090		"[{""reference_id"": ""RHEA:17090"", ""source_assertion"": ""Rhea lists CHEBI:57569 on the substrates side of RHEA:17090 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17090']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17090"", ""source_version"": ""139"", ""title"": ""Rhea 2-dehydro-3-deoxy-6-phosphogluconate-cleaving direction"", ""url"": ""https://www.rhea-db.org/rhea/17090""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-010_cce897a46c15	RHEA:17090	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17090		"[{""reference_id"": ""RHEA:17090"", ""source_assertion"": ""Rhea lists CHEBI:15361 on the products side of RHEA:17090 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17090']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17090"", ""source_version"": ""139"", ""title"": ""Rhea 2-dehydro-3-deoxy-6-phosphogluconate-cleaving direction"", ""url"": ""https://www.rhea-db.org/rhea/17090""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-011_f12843314b0e	RHEA:17090	pathwaymech:produces	CHEBI:59776	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17090		"[{""reference_id"": ""RHEA:17090"", ""source_assertion"": ""Rhea lists CHEBI:59776 on the products side of RHEA:17090 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17090']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17090"", ""source_version"": ""139"", ""title"": ""Rhea 2-dehydro-3-deoxy-6-phosphogluconate-cleaving direction"", ""url"": ""https://www.rhea-db.org/rhea/17090""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-012_0303df67976e	CHEBI:12952	pathwaymech:consumes	RHEA:27703	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27703		"[{""reference_id"": ""RHEA:27703"", ""source_assertion"": ""Rhea lists CHEBI:12952 on the substrates side of RHEA:27703 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27703']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27703"", ""source_version"": ""139"", ""title"": ""RHEA:27703 authority record"", ""url"": ""https://www.rhea-db.org/rhea/27703""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-013_ee240fe4c607	RHEA:27703	pathwaymech:produces	CHEBI:17886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27703		"[{""reference_id"": ""RHEA:27703"", ""source_assertion"": ""Rhea lists CHEBI:17886 on the products side of RHEA:27703 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27703']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27703"", ""source_version"": ""139"", ""title"": ""RHEA:27703 authority record"", ""url"": ""https://www.rhea-db.org/rhea/27703""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-014_c0569d191ec0	CHEBI:15378	pathwaymech:consumes	RHEA:17815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17815		"[{""reference_id"": ""RHEA:17815"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:17815 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17815']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17815"", ""source_version"": ""139"", ""title"": ""RHEA:17815 authority record"", ""url"": ""https://www.rhea-db.org/rhea/17815""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-015_d7110b34f073	CHEBI:17886	pathwaymech:consumes	RHEA:17815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17815		"[{""reference_id"": ""RHEA:17815"", ""source_assertion"": ""Rhea lists CHEBI:17886 on the substrates side of RHEA:17815 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17815']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17815"", ""source_version"": ""139"", ""title"": ""RHEA:17815 authority record"", ""url"": ""https://www.rhea-db.org/rhea/17815""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-016_754774dce5ab	CHEBI:57945	pathwaymech:consumes	RHEA:17815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17815		"[{""reference_id"": ""RHEA:17815"", ""source_assertion"": ""Rhea lists CHEBI:57945 on the substrates side of RHEA:17815 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17815']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17815"", ""source_version"": ""139"", ""title"": ""RHEA:17815 authority record"", ""url"": ""https://www.rhea-db.org/rhea/17815""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-017_2035ec7e5a1b	RHEA:17815	pathwaymech:produces	CHEBI:17360	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17815		"[{""reference_id"": ""RHEA:17815"", ""source_assertion"": ""Rhea lists CHEBI:17360 on the products side of RHEA:17815 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17815']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17815"", ""source_version"": ""139"", ""title"": ""RHEA:17815 authority record"", ""url"": ""https://www.rhea-db.org/rhea/17815""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-018_f3ee2c83305a	RHEA:17815	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17815		"[{""reference_id"": ""RHEA:17815"", ""source_assertion"": ""Rhea lists CHEBI:57540 on the products side of RHEA:17815 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17815']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17815"", ""source_version"": ""139"", ""title"": ""RHEA:17815 authority record"", ""url"": ""https://www.rhea-db.org/rhea/17815""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-019_2689d4d2d8e7	EC:5.3.1.12	pathwaymech:catalyzes	RHEA:27703	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27702		"[{""reference_id"": ""RHEA:27702"", ""source_assertion"": ""Rhea associates EC:5.3.1.12 with the reaction family containing RHEA:27703."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:27702"", ""source_version"": ""139"", ""title"": ""Rhea D-galacturonate isomerase reaction"", ""url"": ""https://www.rhea-db.org/rhea/27702""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-020_cd0b3198be01	EC:1.1.1.58	pathwaymech:catalyzes	RHEA:17815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17813		"[{""reference_id"": ""RHEA:17813"", ""source_assertion"": ""Rhea associates EC:1.1.1.58 with the reaction family containing RHEA:17815."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:17813"", ""source_version"": ""139"", ""title"": ""Rhea tagaturonate reductase reaction"", ""url"": ""https://www.rhea-db.org/rhea/17813""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-021_97306d07bc08	EC:4.2.1.7	pathwaymech:catalyzes	RHEA:15958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15957		"[{""reference_id"": ""RHEA:15957"", ""source_assertion"": ""Rhea associates EC:4.2.1.7 with the reaction family containing RHEA:15958."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:15957"", ""source_version"": ""139"", ""title"": ""Rhea altronate dehydratase reaction"", ""url"": ""https://www.rhea-db.org/rhea/15957""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-022_abf09bc9e204	EC:2.7.1.45	pathwaymech:catalyzes	RHEA:14798	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14797		"[{""reference_id"": ""RHEA:14797"", ""source_assertion"": ""Rhea associates EC:2.7.1.45 with the reaction family containing RHEA:14798."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:14797"", ""source_version"": ""139"", ""title"": ""Rhea 2-dehydro-3-deoxygluconokinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/14797""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-023_652f452cd760	EC:4.1.2.14	pathwaymech:catalyzes	RHEA:17090	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17089		"[{""reference_id"": ""RHEA:17089"", ""source_assertion"": ""Rhea associates EC:4.1.2.14 with the reaction family containing RHEA:17090."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:17089"", ""source_version"": ""139"", ""title"": ""Rhea 2-dehydro-3-deoxy-6-phosphogluconate aldolase reaction"", ""url"": ""https://www.rhea-db.org/rhea/17089""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-024_5fe29124bc0f	RHEA:14798	pathwaymech:precedes	RHEA:17090	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GALACTUROCAT-PWY		"[{""reference_id"": ""MetaCyc:GALACTUROCAT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:14798 before RHEA:17090 in this pathway. Shared intermediate: CHEBI:57569."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GALACTUROCAT-PWY"", ""source_sha256"": ""a1964599a8602ef517dc210d8c683bceeef801c627d351c294922292b970c6bd"", ""source_version"": ""22.5"", ""title"": ""MetaCyc D-galacturonate degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GALACTUROCAT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-025_b5d974ec73f2	RHEA:15958	pathwaymech:precedes	RHEA:14798	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GALACTUROCAT-PWY		"[{""reference_id"": ""MetaCyc:GALACTUROCAT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:15958 before RHEA:14798 in this pathway. Shared intermediate: CHEBI:57990."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GALACTUROCAT-PWY"", ""source_sha256"": ""a1964599a8602ef517dc210d8c683bceeef801c627d351c294922292b970c6bd"", ""source_version"": ""22.5"", ""title"": ""MetaCyc D-galacturonate degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GALACTUROCAT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-026_b7dda9d2236c	RHEA:17815	pathwaymech:precedes	RHEA:15958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GALACTUROCAT-PWY		"[{""reference_id"": ""MetaCyc:GALACTUROCAT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:17815 before RHEA:15958 in this pathway. Shared intermediate: CHEBI:17360."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GALACTUROCAT-PWY"", ""source_sha256"": ""a1964599a8602ef517dc210d8c683bceeef801c627d351c294922292b970c6bd"", ""source_version"": ""22.5"", ""title"": ""MetaCyc D-galacturonate degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GALACTUROCAT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_GALACTUROCAT-PWY_edge-027_4a1147a8257d	RHEA:27703	pathwaymech:precedes	RHEA:17815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GALACTUROCAT-PWY		"[{""reference_id"": ""MetaCyc:GALACTUROCAT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:27703 before RHEA:17815 in this pathway. Shared intermediate: CHEBI:17886."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GALACTUROCAT-PWY"", ""source_sha256"": ""a1964599a8602ef517dc210d8c683bceeef801c627d351c294922292b970c6bd"", ""source_version"": ""22.5"", ""title"": ""MetaCyc D-galacturonate degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GALACTUROCAT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-001_93b79847a381	CHEBI:30612	pathwaymech:consumes	RHEA:14574	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14574		"[{""reference_id"": ""RHEA:14574"", ""source_assertion"": ""Rhea lists CHEBI:30612 on the substrates side of RHEA:14574 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14574']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14574"", ""source_version"": ""139"", ""title"": ""Rhea D-glucarate-dehydrating direction"", ""url"": ""https://www.rhea-db.org/rhea/14574""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-002_8f3ddb46e030	RHEA:14574	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14574		"[{""reference_id"": ""RHEA:14574"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:14574 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14574']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14574"", ""source_version"": ""139"", ""title"": ""Rhea D-glucarate-dehydrating direction"", ""url"": ""https://www.rhea-db.org/rhea/14574""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-003_0f46109459de	RHEA:14574	pathwaymech:produces	CHEBI:42819	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14574		"[{""reference_id"": ""RHEA:14574"", ""source_assertion"": ""Rhea lists CHEBI:42819 on the products side of RHEA:14574 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14574']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14574"", ""source_version"": ""139"", ""title"": ""Rhea D-glucarate-dehydrating direction"", ""url"": ""https://www.rhea-db.org/rhea/14574""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-004_4a50079be72b	CHEBI:15378	pathwaymech:consumes	RHEA:18843	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18843		"[{""reference_id"": ""RHEA:18843"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:18843 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18843']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18843"", ""source_version"": ""139"", ""title"": ""Rhea NADPH-dependent tartronate-semialdehyde reductase reduction direction"", ""url"": ""https://www.rhea-db.org/rhea/18843""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-005_f8cb03f58cae	CHEBI:57783	pathwaymech:consumes	RHEA:18843	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18843		"[{""reference_id"": ""RHEA:18843"", ""source_assertion"": ""Rhea lists CHEBI:57783 on the substrates side of RHEA:18843 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18843']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18843"", ""source_version"": ""139"", ""title"": ""Rhea NADPH-dependent tartronate-semialdehyde reductase reduction direction"", ""url"": ""https://www.rhea-db.org/rhea/18843""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-006_6f87aef59a1c	CHEBI:57978	pathwaymech:consumes	RHEA:18843	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18843		"[{""reference_id"": ""RHEA:18843"", ""source_assertion"": ""Rhea lists CHEBI:57978 on the substrates side of RHEA:18843 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18843']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18843"", ""source_version"": ""139"", ""title"": ""Rhea NADPH-dependent tartronate-semialdehyde reductase reduction direction"", ""url"": ""https://www.rhea-db.org/rhea/18843""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-007_70bb2ae64baa	RHEA:18843	pathwaymech:produces	CHEBI:16659	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18843		"[{""reference_id"": ""RHEA:18843"", ""source_assertion"": ""Rhea lists CHEBI:16659 on the products side of RHEA:18843 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18843']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18843"", ""source_version"": ""139"", ""title"": ""Rhea NADPH-dependent tartronate-semialdehyde reductase reduction direction"", ""url"": ""https://www.rhea-db.org/rhea/18843""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-008_2fa179772177	RHEA:18843	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18843		"[{""reference_id"": ""RHEA:18843"", ""source_assertion"": ""Rhea lists CHEBI:58349 on the products side of RHEA:18843 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18843']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18843"", ""source_version"": ""139"", ""title"": ""Rhea NADPH-dependent tartronate-semialdehyde reductase reduction direction"", ""url"": ""https://www.rhea-db.org/rhea/18843""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-009_69bcd98ef15b	CHEBI:15378	pathwaymech:consumes	RHEA:18847	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18847		"[{""reference_id"": ""RHEA:18847"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:18847 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18847']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18847"", ""source_version"": ""139"", ""title"": ""Rhea NADH-dependent tartronate-semialdehyde reductase reduction direction"", ""url"": ""https://www.rhea-db.org/rhea/18847""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-010_79ac20316feb	CHEBI:57945	pathwaymech:consumes	RHEA:18847	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18847		"[{""reference_id"": ""RHEA:18847"", ""source_assertion"": ""Rhea lists CHEBI:57945 on the substrates side of RHEA:18847 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18847']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18847"", ""source_version"": ""139"", ""title"": ""Rhea NADH-dependent tartronate-semialdehyde reductase reduction direction"", ""url"": ""https://www.rhea-db.org/rhea/18847""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-011_8a87d288f88f	CHEBI:57978	pathwaymech:consumes	RHEA:18847	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18847		"[{""reference_id"": ""RHEA:18847"", ""source_assertion"": ""Rhea lists CHEBI:57978 on the substrates side of RHEA:18847 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18847']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18847"", ""source_version"": ""139"", ""title"": ""Rhea NADH-dependent tartronate-semialdehyde reductase reduction direction"", ""url"": ""https://www.rhea-db.org/rhea/18847""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-012_59546e1daa27	RHEA:18847	pathwaymech:produces	CHEBI:16659	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18847		"[{""reference_id"": ""RHEA:18847"", ""source_assertion"": ""Rhea lists CHEBI:16659 on the products side of RHEA:18847 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18847']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18847"", ""source_version"": ""139"", ""title"": ""Rhea NADH-dependent tartronate-semialdehyde reductase reduction direction"", ""url"": ""https://www.rhea-db.org/rhea/18847""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-013_4ae7f5257fef	RHEA:18847	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18847		"[{""reference_id"": ""RHEA:18847"", ""source_assertion"": ""Rhea lists CHEBI:57540 on the products side of RHEA:18847 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18847']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18847"", ""source_version"": ""139"", ""title"": ""Rhea NADH-dependent tartronate-semialdehyde reductase reduction direction"", ""url"": ""https://www.rhea-db.org/rhea/18847""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-014_047211a518b1	CHEBI:16659	pathwaymech:consumes	RHEA:27378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27378		"[{""reference_id"": ""RHEA:27378"", ""source_assertion"": ""Rhea lists CHEBI:16659 on the substrates side of RHEA:27378 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27378']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27378"", ""source_version"": ""139"", ""title"": ""Rhea 2-phosphoglycerate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/27378""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-015_e934714a41f4	CHEBI:30616	pathwaymech:consumes	RHEA:27378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27378		"[{""reference_id"": ""RHEA:27378"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:27378 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27378']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27378"", ""source_version"": ""139"", ""title"": ""Rhea 2-phosphoglycerate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/27378""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-016_d27b304f9bc4	RHEA:27378	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27378		"[{""reference_id"": ""RHEA:27378"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:27378 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27378']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27378"", ""source_version"": ""139"", ""title"": ""Rhea 2-phosphoglycerate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/27378""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-017_610dd39be281	RHEA:27378	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27378		"[{""reference_id"": ""RHEA:27378"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:27378 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27378']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27378"", ""source_version"": ""139"", ""title"": ""Rhea 2-phosphoglycerate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/27378""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-018_dadf6ae7f39a	RHEA:27378	pathwaymech:produces	CHEBI:58289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27378		"[{""reference_id"": ""RHEA:27378"", ""source_assertion"": ""Rhea lists CHEBI:58289 on the products side of RHEA:27378 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27378']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27378"", ""source_version"": ""139"", ""title"": ""Rhea 2-phosphoglycerate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/27378""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-019_66a35f2afb5d	CHEBI:42819	pathwaymech:consumes	RHEA:27727	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27727		"[{""reference_id"": ""RHEA:27727"", ""source_assertion"": ""Rhea lists CHEBI:42819 on the substrates side of RHEA:27727 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27727']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27727"", ""source_version"": ""139"", ""title"": ""RHEA:27727 authority record"", ""url"": ""https://www.rhea-db.org/rhea/27727""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-020_215e8a8a0ec7	RHEA:27727	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27727		"[{""reference_id"": ""RHEA:27727"", ""source_assertion"": ""Rhea lists CHEBI:15361 on the products side of RHEA:27727 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27727']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27727"", ""source_version"": ""139"", ""title"": ""RHEA:27727 authority record"", ""url"": ""https://www.rhea-db.org/rhea/27727""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-021_58ede0263c7d	RHEA:27727	pathwaymech:produces	CHEBI:57978	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27727		"[{""reference_id"": ""RHEA:27727"", ""source_assertion"": ""Rhea lists CHEBI:57978 on the products side of RHEA:27727 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27727']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27727"", ""source_version"": ""139"", ""title"": ""RHEA:27727 authority record"", ""url"": ""https://www.rhea-db.org/rhea/27727""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-022_cb7cbc6a136a	EC:4.2.1.40	pathwaymech:catalyzes	RHEA:14574	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14573		"[{""reference_id"": ""RHEA:14573"", ""source_assertion"": ""Rhea associates EC:4.2.1.40 with the reaction family containing RHEA:14574."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:14573"", ""source_version"": ""139"", ""title"": ""Rhea D-glucarate dehydratase reaction"", ""url"": ""https://www.rhea-db.org/rhea/14573""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-023_ca49c6e6c491	EC:1.1.1.60	pathwaymech:catalyzes	RHEA:18843	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18841		"[{""reference_id"": ""RHEA:18841"", ""source_assertion"": ""Rhea associates EC:1.1.1.60 with the reaction family containing RHEA:18843."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:18841"", ""source_version"": ""139"", ""title"": ""Rhea NADPH-dependent tartronate-semialdehyde reductase reaction"", ""url"": ""https://www.rhea-db.org/rhea/18841""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-024_a386ae10df80	EC:1.1.1.60	pathwaymech:catalyzes	RHEA:18847	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18845		"[{""reference_id"": ""RHEA:18845"", ""source_assertion"": ""Rhea associates EC:1.1.1.60 with the reaction family containing RHEA:18847."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:18845"", ""source_version"": ""139"", ""title"": ""Rhea NADH-dependent tartronate-semialdehyde reductase reaction"", ""url"": ""https://www.rhea-db.org/rhea/18845""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-025_dde859204413	EC:2.7.1.165	pathwaymech:catalyzes	RHEA:27378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27377		"[{""reference_id"": ""RHEA:27377"", ""source_assertion"": ""Rhea associates EC:2.7.1.165 with the reaction family containing RHEA:27378."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:27377"", ""source_version"": ""139"", ""title"": ""Rhea D-glycerate 2-kinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/27377""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-026_4de72b64bac9	RHEA:14574	pathwaymech:precedes	RHEA:27727	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLUCARDEG-PWY		"[{""reference_id"": ""MetaCyc:GLUCARDEG-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:14574 before RHEA:27727 in this pathway. Shared intermediate: CHEBI:42819."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GLUCARDEG-PWY"", ""source_sha256"": ""51237b8f8e360d2e8cb24c3d933c31618b83963a584db397d745aa7cd19155f0"", ""source_version"": ""22.5"", ""title"": ""MetaCyc D-glucarate degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLUCARDEG-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-027_914d7607e5bb	RHEA:18843	pathwaymech:precedes	RHEA:27378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLUCARDEG-PWY		"[{""reference_id"": ""MetaCyc:GLUCARDEG-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:18843 before RHEA:27378 in this pathway. Shared intermediate: CHEBI:16659."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GLUCARDEG-PWY"", ""source_sha256"": ""51237b8f8e360d2e8cb24c3d933c31618b83963a584db397d745aa7cd19155f0"", ""source_version"": ""22.5"", ""title"": ""MetaCyc D-glucarate degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLUCARDEG-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-028_32bee0ea6134	RHEA:18847	pathwaymech:precedes	RHEA:27378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLUCARDEG-PWY		"[{""reference_id"": ""MetaCyc:GLUCARDEG-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:18847 before RHEA:27378 in this pathway. Shared intermediate: CHEBI:16659."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GLUCARDEG-PWY"", ""source_sha256"": ""51237b8f8e360d2e8cb24c3d933c31618b83963a584db397d745aa7cd19155f0"", ""source_version"": ""22.5"", ""title"": ""MetaCyc D-glucarate degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLUCARDEG-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-029_24d5346a6faa	RHEA:27727	pathwaymech:precedes	RHEA:18843	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLUCARDEG-PWY		"[{""reference_id"": ""MetaCyc:GLUCARDEG-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:27727 before RHEA:18843 in this pathway. Shared intermediate: CHEBI:57978."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GLUCARDEG-PWY"", ""source_sha256"": ""51237b8f8e360d2e8cb24c3d933c31618b83963a584db397d745aa7cd19155f0"", ""source_version"": ""22.5"", ""title"": ""MetaCyc D-glucarate degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLUCARDEG-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_GLUCARDEG-PWY_edge-030_6f3dc113d068	RHEA:27727	pathwaymech:precedes	RHEA:18847	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLUCARDEG-PWY		"[{""reference_id"": ""MetaCyc:GLUCARDEG-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:27727 before RHEA:18847 in this pathway. Shared intermediate: CHEBI:57978."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GLUCARDEG-PWY"", ""source_sha256"": ""51237b8f8e360d2e8cb24c3d933c31618b83963a584db397d745aa7cd19155f0"", ""source_version"": ""22.5"", ""title"": ""MetaCyc D-glucarate degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLUCARDEG-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_XYLCAT-PWY_edge-001_b13012ee7dd1	CHEBI:17140	pathwaymech:consumes	RHEA:10965	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10965		"[{""reference_id"": ""RHEA:10965"", ""source_assertion"": ""Rhea lists CHEBI:17140 on the substrates side of RHEA:10965 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10965']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10965"", ""source_version"": ""139"", ""title"": ""Rhea D-xylulose-5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10965""}]"	""
pathwaymech:MetaCyc_XYLCAT-PWY_edge-002_b2a1dfac39f9	CHEBI:30616	pathwaymech:consumes	RHEA:10965	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10965		"[{""reference_id"": ""RHEA:10965"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:10965 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10965']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10965"", ""source_version"": ""139"", ""title"": ""Rhea D-xylulose-5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10965""}]"	""
pathwaymech:MetaCyc_XYLCAT-PWY_edge-003_d186ec22479d	RHEA:10965	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10965		"[{""reference_id"": ""RHEA:10965"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:10965 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10965']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10965"", ""source_version"": ""139"", ""title"": ""Rhea D-xylulose-5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10965""}]"	""
pathwaymech:MetaCyc_XYLCAT-PWY_edge-004_88a44cfc1573	RHEA:10965	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10965		"[{""reference_id"": ""RHEA:10965"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:10965 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10965']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10965"", ""source_version"": ""139"", ""title"": ""Rhea D-xylulose-5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10965""}]"	""
pathwaymech:MetaCyc_XYLCAT-PWY_edge-005_ce78b3dd6684	RHEA:10965	pathwaymech:produces	CHEBI:57737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10965		"[{""reference_id"": ""RHEA:10965"", ""source_assertion"": ""Rhea lists CHEBI:57737 on the products side of RHEA:10965 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10965']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10965"", ""source_version"": ""139"", ""title"": ""Rhea D-xylulose-5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10965""}]"	""
pathwaymech:MetaCyc_XYLCAT-PWY_edge-006_8fd95b571382	CHEBI:28518	pathwaymech:consumes	RHEA:22817	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22817		"[{""reference_id"": ""RHEA:22817"", ""source_assertion"": ""Rhea lists CHEBI:28518 on the substrates side of RHEA:22817 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22817']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22817"", ""source_version"": ""139"", ""title"": ""RHEA:22817 authority record"", ""url"": ""https://www.rhea-db.org/rhea/22817""}]"	""
pathwaymech:MetaCyc_XYLCAT-PWY_edge-007_38fbeec520e3	RHEA:22817	pathwaymech:produces	CHEBI:188998	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22817		"[{""reference_id"": ""RHEA:22817"", ""source_assertion"": ""Rhea lists CHEBI:188998 on the products side of RHEA:22817 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22817']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22817"", ""source_version"": ""139"", ""title"": ""RHEA:22817 authority record"", ""url"": ""https://www.rhea-db.org/rhea/22817""}]"	""
pathwaymech:MetaCyc_XYLCAT-PWY_edge-008_dc4dd18ed2da	EC:5.3.1.5	pathwaymech:catalyzes	RHEA:22817	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22816		"[{""reference_id"": ""RHEA:22816"", ""source_assertion"": ""Rhea associates EC:5.3.1.5 with the reaction family containing RHEA:22817."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:22816"", ""source_version"": ""139"", ""title"": ""Rhea xylose isomerase reaction"", ""url"": ""https://www.rhea-db.org/rhea/22816""}]"	""
pathwaymech:MetaCyc_XYLCAT-PWY_edge-009_fae212be5086	EC:2.7.1.17	pathwaymech:catalyzes	RHEA:10965	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10964		"[{""reference_id"": ""RHEA:10964"", ""source_assertion"": ""Rhea associates EC:2.7.1.17 with the reaction family containing RHEA:10965."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:10964"", ""source_version"": ""139"", ""title"": ""Rhea xylulokinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/10964""}]"	""
pathwaymech:MetaCyc_XYLCAT-PWY_edge-010_7cd14409047d	RHEA:22817	pathwaymech:precedes	RHEA:10965	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:XYLCAT-PWY		"[{""reference_id"": ""MetaCyc:XYLCAT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:22817 before RHEA:10965 in this pathway. The source ordering may bridge anomer-specific and broader substrate classes."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:XYLCAT-PWY"", ""source_sha256"": ""b540c84eb891c236fa15ea61560eaf9d0a4bdb28bae7c2fd43e27791ff6ea2d4"", ""source_version"": ""22.5"", ""title"": ""MetaCyc D-xylose degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:XYLCAT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_XYLCAT-PWY_edge-011_7bf34121e905	UniProtKB:P00944	pathwaymech:enables	RHEA:22817	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00944		"[{""reference_id"": ""UniProtKB:P00944"", ""source_assertion"": ""UniProt annotates UniProtKB:P00944 with catalytic activity for the reaction family of RHEA:22817. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00944"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00944 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00944.json""}]"	""
pathwaymech:MetaCyc_XYLCAT-PWY_edge-012_bbeae06da2e0	UniProtKB:P00944	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00944		"[{""reference_id"": ""UniProtKB:P00944"", ""source_assertion"": ""UniProt locates UniProtKB:P00944 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P00944"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00944 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00944.json""}]"	""
pathwaymech:MetaCyc_XYLCAT-PWY_edge-013_043ebce0846b	UniProtKB:P00944	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00944		"[{""reference_id"": ""UniProtKB:P00944"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P00944 (evidence: ECO:0000250). Binds 2 magnesium ions per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P00944"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00944 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00944.json""}]"	""
pathwaymech:MetaCyc_XYLCAT-PWY_edge-014_5ee299e1c6d8	UniProtKB:P09099	pathwaymech:enables	RHEA:10965	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09099		"[{""reference_id"": ""UniProtKB:P09099"", ""source_assertion"": ""UniProt annotates UniProtKB:P09099 with catalytic activity for the reaction family of RHEA:10965. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P09099"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P09099 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P09099.json""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-001_da4d0bce8572	CHEBI:15378	pathwaymech:consumes	MetaCyc:LYSDECARBOX-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:LYSDECARBOX-RXN|MetaCyc:PROTON		"[{""reference_id"": ""MetaCyc:LYSDECARBOX-RXN"", ""source_assertion"": ""The native left side assigns PROTON with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""LYSDECARBOX-RXN\""]/left[Compound/@frameid=\""PROTON\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The source PROTON CML structure and InChI specify the selected chemical charge and stereochemical form."", ""source_locator"": ""Compound[@frameid=\""PROTON\""]/cml/molecule/@formalCharge; cml/molecule/formula; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:15378 independently has the same full InChI as native PROTON, including charge and any specified stereochemistry."", ""source_locator"": ""statements[subject=\""CHEBI:15378\"",predicate=\""chemrof:inchi_string\""]; chemrof:generalized_empirical_formula; chemrof:charge""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers the complete original uncompressed Semantic SQL database; selected term locators identify each cited chemical"", ""title"": ""ChEBI exact chemical structures and ionic forms"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:LYSDECARBOX-RXN"", ""source_sha256"": ""f124e4cd7163352a336b9dd574b84eb6792385b4274eb88eed549e8f397a7b85"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native LYSDECARBOX-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:LYSDECARBOX-RXN""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PROTON"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-002_16ea8b78d88f	CHEBI:32551	pathwaymech:consumes	MetaCyc:LYSDECARBOX-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:LYS|MetaCyc:LYSDECARBOX-RXN		"[{""reference_id"": ""MetaCyc:LYSDECARBOX-RXN"", ""source_assertion"": ""The native left side assigns LYS with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""LYSDECARBOX-RXN\""]/left[Compound/@frameid=\""LYS\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:LYS"", ""source_assertion"": ""The source LYS CML structure and InChI specify the selected chemical charge and stereochemical form."", ""source_locator"": ""Compound[@frameid=\""LYS\""]/cml/molecule/@formalCharge; cml/molecule/formula; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:32551 independently has the same full InChI as native LYS, including charge and any specified stereochemistry."", ""source_locator"": ""statements[subject=\""CHEBI:32551\"",predicate=\""chemrof:inchi_string\""]; chemrof:generalized_empirical_formula; chemrof:charge""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers the complete original uncompressed Semantic SQL database; selected term locators identify each cited chemical"", ""title"": ""ChEBI exact chemical structures and ionic forms"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:LYS"", ""source_sha256"": ""87090d8347b0a4e6753b8aa50f70c50c1881efc0f4d079e9472b3b7fd68122c4"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native LYS"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:LYS""}, {""id"": ""MetaCyc:LYSDECARBOX-RXN"", ""source_sha256"": ""f124e4cd7163352a336b9dd574b84eb6792385b4274eb88eed549e8f397a7b85"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native LYSDECARBOX-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:LYSDECARBOX-RXN""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-003_f06b6f3dee85	MetaCyc:LYSDECARBOX-RXN	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:CARBON-DIOXIDE|MetaCyc:LYSDECARBOX-RXN		"[{""reference_id"": ""MetaCyc:LYSDECARBOX-RXN"", ""source_assertion"": ""The native right side assigns CARBON-DIOXIDE with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""LYSDECARBOX-RXN\""]/right[Compound/@frameid=\""CARBON-DIOXIDE\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:CARBON-DIOXIDE"", ""source_assertion"": ""The source CARBON-DIOXIDE CML structure and InChI specify the selected chemical charge and stereochemical form."", ""source_locator"": ""Compound[@frameid=\""CARBON-DIOXIDE\""]/cml/molecule/@formalCharge; cml/molecule/formula; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:16526 independently has the same full InChI as native CARBON-DIOXIDE, including charge and any specified stereochemistry."", ""source_locator"": ""statements[subject=\""CHEBI:16526\"",predicate=\""chemrof:inchi_string\""]; chemrof:generalized_empirical_formula; chemrof:charge""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers the complete original uncompressed Semantic SQL database; selected term locators identify each cited chemical"", ""title"": ""ChEBI exact chemical structures and ionic forms"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:CARBON-DIOXIDE"", ""source_sha256"": ""dee7bb381e506053f7e7560e66dd049cb5771f075fc8eb9a20479eed8f1eeb54"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CARBON-DIOXIDE"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CARBON-DIOXIDE""}, {""id"": ""MetaCyc:LYSDECARBOX-RXN"", ""source_sha256"": ""f124e4cd7163352a336b9dd574b84eb6792385b4274eb88eed549e8f397a7b85"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native LYSDECARBOX-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:LYSDECARBOX-RXN""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-004_9191dc49da45	MetaCyc:LYSDECARBOX-RXN	pathwaymech:produces	CHEBI:58384	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:CADAVERINE|MetaCyc:LYSDECARBOX-RXN		"[{""reference_id"": ""MetaCyc:LYSDECARBOX-RXN"", ""source_assertion"": ""The native right side assigns CADAVERINE with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""LYSDECARBOX-RXN\""]/right[Compound/@frameid=\""CADAVERINE\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:CADAVERINE"", ""source_assertion"": ""The source CADAVERINE CML structure and InChI specify the selected chemical charge and stereochemical form."", ""source_locator"": ""Compound[@frameid=\""CADAVERINE\""]/cml/molecule/@formalCharge; cml/molecule/formula; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:58384 independently has the same full InChI as native CADAVERINE, including charge and any specified stereochemistry."", ""source_locator"": ""statements[subject=\""CHEBI:58384\"",predicate=\""chemrof:inchi_string\""]; chemrof:generalized_empirical_formula; chemrof:charge""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers the complete original uncompressed Semantic SQL database; selected term locators identify each cited chemical"", ""title"": ""ChEBI exact chemical structures and ionic forms"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:CADAVERINE"", ""source_sha256"": ""e05947d9b4b1bdd3697a96b9740cb0dfd3b0b5f4271ceb3a0628a959a40ccbe2"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CADAVERINE"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CADAVERINE""}, {""id"": ""MetaCyc:LYSDECARBOX-RXN"", ""source_sha256"": ""f124e4cd7163352a336b9dd574b84eb6792385b4274eb88eed549e8f397a7b85"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native LYSDECARBOX-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:LYSDECARBOX-RXN""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-005_53ba8150408c	CHEBI:58384	pathwaymech:consumes	MetaCyc:RXN-10995	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:CADAVERINE|MetaCyc:RXN-10995		"[{""reference_id"": ""MetaCyc:RXN-10995"", ""source_assertion"": ""The native left side assigns CADAVERINE with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-10995\""]/left[Compound/@frameid=\""CADAVERINE\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:CADAVERINE"", ""source_assertion"": ""The source CADAVERINE CML structure and InChI specify the selected chemical charge and stereochemical form."", ""source_locator"": ""Compound[@frameid=\""CADAVERINE\""]/cml/molecule/@formalCharge; cml/molecule/formula; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:58384 independently has the same full InChI as native CADAVERINE, including charge and any specified stereochemistry."", ""source_locator"": ""statements[subject=\""CHEBI:58384\"",predicate=\""chemrof:inchi_string\""]; chemrof:generalized_empirical_formula; chemrof:charge""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers the complete original uncompressed Semantic SQL database; selected term locators identify each cited chemical"", ""title"": ""ChEBI exact chemical structures and ionic forms"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:CADAVERINE"", ""source_sha256"": ""e05947d9b4b1bdd3697a96b9740cb0dfd3b0b5f4271ceb3a0628a959a40ccbe2"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CADAVERINE"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CADAVERINE""}, {""id"": ""MetaCyc:RXN-10995"", ""source_sha256"": ""755a35c3df4bd60be7b026bb92f95fc53473aa5c2baec77e1b9acb70060b71c2"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10995"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10995""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-006_cf0835ac3f4a	CHEBI:15379	pathwaymech:consumes	MetaCyc:RXN-10995	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:OXYGEN-MOLECULE|MetaCyc:RXN-10995		"[{""reference_id"": ""MetaCyc:RXN-10995"", ""source_assertion"": ""The native left side assigns OXYGEN-MOLECULE with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-10995\""]/left[Compound/@frameid=\""OXYGEN-MOLECULE\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:OXYGEN-MOLECULE"", ""source_assertion"": ""The source OXYGEN-MOLECULE CML structure and InChI specify the selected chemical charge and stereochemical form."", ""source_locator"": ""Compound[@frameid=\""OXYGEN-MOLECULE\""]/cml/molecule/@formalCharge; cml/molecule/formula; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:15379 independently has the same full InChI as native OXYGEN-MOLECULE, including charge and any specified stereochemistry."", ""source_locator"": ""statements[subject=\""CHEBI:15379\"",predicate=\""chemrof:inchi_string\""]; chemrof:generalized_empirical_formula; chemrof:charge""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers the complete original uncompressed Semantic SQL database; selected term locators identify each cited chemical"", ""title"": ""ChEBI exact chemical structures and ionic forms"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:OXYGEN-MOLECULE"", ""source_sha256"": ""1b33927a897ac326b7a788e5ff5df7490e8c73cb5e1690869353f154b0998a6f"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native OXYGEN-MOLECULE"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:OXYGEN-MOLECULE""}, {""id"": ""MetaCyc:RXN-10995"", ""source_sha256"": ""755a35c3df4bd60be7b026bb92f95fc53473aa5c2baec77e1b9acb70060b71c2"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10995"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10995""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-007_d76a3b18e0e1	MetaCyc:Donor-H2	pathwaymech:consumes	MetaCyc:RXN-10995	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Donor-H2|MetaCyc:RXN-10995	The native reaction retains generic reduced/oxidized electron-acceptor classes. It does not identify a specific physiological coelicolor donor. The S. sviceus NADPH/NADH experiments and the sequence-unmatched 2023 DesABC preparation do not establish donor specificity for this exact coelicolor protein.	"[{""reference_id"": ""MetaCyc:RXN-10995"", ""source_assertion"": ""The native left side assigns Donor-H2 with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-10995\""]/left[Compound/@frameid=\""Donor-H2\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:Donor-H2"", ""source_assertion"": ""This native object denotes a generic electron-acceptor redox class rather than a specific flavin, nicotinamide donor or physiological partner."", ""source_locator"": ""Compound/common-name; parent; comment; dblink""}]"	"[{""id"": ""MetaCyc:Donor-H2"", ""source_sha256"": ""a2cad5be6b6ec96bc2fabaa2d1d7fbcf0ef6549b846dce6870dd0879ac2e7bb9"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native Donor-H2"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Donor-H2""}, {""id"": ""MetaCyc:RXN-10995"", ""source_sha256"": ""755a35c3df4bd60be7b026bb92f95fc53473aa5c2baec77e1b9acb70060b71c2"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10995"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10995""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-008_ac02ed197da6	MetaCyc:RXN-10995	pathwaymech:produces	MetaCyc:CPD-11953	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-11953|MetaCyc:RXN-10995		"[{""reference_id"": ""MetaCyc:RXN-10995"", ""source_assertion"": ""The native right side assigns CPD-11953 with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-10995\""]/right[Compound/@frameid=\""CPD-11953\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:CPD-11953"", ""source_assertion"": ""The independently issued native compound preserves its CML structure and ionic form; stale external chemical cross-references are not treated as exact equivalence."", ""source_locator"": ""Compound[@frameid=\""CPD-11953\""]/cml/molecule; inchi; dblink""}]"	"[{""id"": ""MetaCyc:CPD-11953"", ""source_sha256"": ""0c904cb264cfed4e678ec9a35545682ba6909fd6bb012fa197280989b42ccb6b"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CPD-11953"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-11953""}, {""id"": ""MetaCyc:RXN-10995"", ""source_sha256"": ""755a35c3df4bd60be7b026bb92f95fc53473aa5c2baec77e1b9acb70060b71c2"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10995"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10995""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-009_0218bb3fbb74	MetaCyc:RXN-10995	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:RXN-10995|MetaCyc:WATER		"[{""reference_id"": ""MetaCyc:RXN-10995"", ""source_assertion"": ""The native right side assigns WATER with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-10995\""]/right[Compound/@frameid=\""WATER\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:WATER"", ""source_assertion"": ""The source WATER CML structure and InChI specify the selected chemical charge and stereochemical form."", ""source_locator"": ""Compound[@frameid=\""WATER\""]/cml/molecule/@formalCharge; cml/molecule/formula; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:15377 independently has the same full InChI as native WATER, including charge and any specified stereochemistry."", ""source_locator"": ""statements[subject=\""CHEBI:15377\"",predicate=\""chemrof:inchi_string\""]; chemrof:generalized_empirical_formula; chemrof:charge""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers the complete original uncompressed Semantic SQL database; selected term locators identify each cited chemical"", ""title"": ""ChEBI exact chemical structures and ionic forms"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:RXN-10995"", ""source_sha256"": ""755a35c3df4bd60be7b026bb92f95fc53473aa5c2baec77e1b9acb70060b71c2"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10995"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10995""}, {""id"": ""MetaCyc:WATER"", ""source_sha256"": ""47621552fb854daf04df0375c4540b0f42103652ec2d2a5f384ad06dead702e3"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native WATER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:WATER""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-010_b36bab03446f	MetaCyc:RXN-10995	pathwaymech:produces	MetaCyc:Acceptor	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Acceptor|MetaCyc:RXN-10995	The native reaction retains generic reduced/oxidized electron-acceptor classes. It does not identify a specific physiological coelicolor donor. The S. sviceus NADPH/NADH experiments and the sequence-unmatched 2023 DesABC preparation do not establish donor specificity for this exact coelicolor protein.	"[{""reference_id"": ""MetaCyc:RXN-10995"", ""source_assertion"": ""The native right side assigns Acceptor with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-10995\""]/right[Compound/@frameid=\""Acceptor\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:Acceptor"", ""source_assertion"": ""This native object denotes a generic electron-acceptor redox class rather than a specific flavin, nicotinamide donor or physiological partner."", ""source_locator"": ""Compound/common-name; parent; comment; dblink""}]"	"[{""id"": ""MetaCyc:Acceptor"", ""source_sha256"": ""ec1f3b9cc8b8fcc9615706ab317adc59d9117883ce6631a30b8c795f4a3fe19f"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native Acceptor"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Acceptor""}, {""id"": ""MetaCyc:RXN-10995"", ""source_sha256"": ""755a35c3df4bd60be7b026bb92f95fc53473aa5c2baec77e1b9acb70060b71c2"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10995"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10995""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-011_ce0d9447c5bf	MetaCyc:RXN-10995	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:PROTON|MetaCyc:RXN-10995		"[{""reference_id"": ""MetaCyc:RXN-10995"", ""source_assertion"": ""The native right side assigns PROTON with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-10995\""]/right[Compound/@frameid=\""PROTON\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The source PROTON CML structure and InChI specify the selected chemical charge and stereochemical form."", ""source_locator"": ""Compound[@frameid=\""PROTON\""]/cml/molecule/@formalCharge; cml/molecule/formula; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:15378 independently has the same full InChI as native PROTON, including charge and any specified stereochemistry."", ""source_locator"": ""statements[subject=\""CHEBI:15378\"",predicate=\""chemrof:inchi_string\""]; chemrof:generalized_empirical_formula; chemrof:charge""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers the complete original uncompressed Semantic SQL database; selected term locators identify each cited chemical"", ""title"": ""ChEBI exact chemical structures and ionic forms"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PROTON"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}, {""id"": ""MetaCyc:RXN-10995"", ""source_sha256"": ""755a35c3df4bd60be7b026bb92f95fc53473aa5c2baec77e1b9acb70060b71c2"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10995"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10995""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-012_b7bf7f99df2a	MetaCyc:CPD-11953	pathwaymech:consumes	MetaCyc:RXN-10996	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-11953|MetaCyc:RXN-10996		"[{""reference_id"": ""MetaCyc:RXN-10996"", ""source_assertion"": ""The native left side assigns CPD-11953 with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-10996\""]/left[Compound/@frameid=\""CPD-11953\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:CPD-11953"", ""source_assertion"": ""The independently issued native compound preserves its CML structure and ionic form; stale external chemical cross-references are not treated as exact equivalence."", ""source_locator"": ""Compound[@frameid=\""CPD-11953\""]/cml/molecule; inchi; dblink""}]"	"[{""id"": ""MetaCyc:CPD-11953"", ""source_sha256"": ""0c904cb264cfed4e678ec9a35545682ba6909fd6bb012fa197280989b42ccb6b"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CPD-11953"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-11953""}, {""id"": ""MetaCyc:RXN-10996"", ""source_sha256"": ""d21cd0a6068731fca241a5729dbb74fc7e06faa504cc2b17f9d0a968c94dc6fa"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10996"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10996""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-013_589925291444	CHEBI:57292	pathwaymech:consumes	MetaCyc:RXN-10996	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:RXN-10996|MetaCyc:SUC-COA		"[{""reference_id"": ""MetaCyc:RXN-10996"", ""source_assertion"": ""The native left side assigns SUC-COA with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-10996\""]/left[Compound/@frameid=\""SUC-COA\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:SUC-COA"", ""source_assertion"": ""The source SUC-COA CML structure and InChI specify the selected chemical charge and stereochemical form."", ""source_locator"": ""Compound[@frameid=\""SUC-COA\""]/cml/molecule/@formalCharge; cml/molecule/formula; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:57292 independently has the same full InChI as native SUC-COA, including charge and any specified stereochemistry."", ""source_locator"": ""statements[subject=\""CHEBI:57292\"",predicate=\""chemrof:inchi_string\""]; chemrof:generalized_empirical_formula; chemrof:charge""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers the complete original uncompressed Semantic SQL database; selected term locators identify each cited chemical"", ""title"": ""ChEBI exact chemical structures and ionic forms"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:RXN-10996"", ""source_sha256"": ""d21cd0a6068731fca241a5729dbb74fc7e06faa504cc2b17f9d0a968c94dc6fa"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10996"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10996""}, {""id"": ""MetaCyc:SUC-COA"", ""source_sha256"": ""1fe54faca97094a0871c6d8ac554d62d5310f2942a774209b3c178cc57c74e20"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native SUC-COA"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:SUC-COA""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-014_e75f2dd9d191	MetaCyc:RXN-10996	pathwaymech:produces	MetaCyc:CPD-11955	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-11955|MetaCyc:RXN-10996		"[{""reference_id"": ""MetaCyc:RXN-10996"", ""source_assertion"": ""The native right side assigns CPD-11955 with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-10996\""]/right[Compound/@frameid=\""CPD-11955\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:CPD-11955"", ""source_assertion"": ""The independently issued native compound preserves its CML structure and ionic form; stale external chemical cross-references are not treated as exact equivalence."", ""source_locator"": ""Compound[@frameid=\""CPD-11955\""]/cml/molecule; inchi; dblink""}]"	"[{""id"": ""MetaCyc:CPD-11955"", ""source_sha256"": ""5197d2b33565fbf0f0628000ff0de41724b9c6f86cbc2cafb18ea00b99a370db"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CPD-11955"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-11955""}, {""id"": ""MetaCyc:RXN-10996"", ""source_sha256"": ""d21cd0a6068731fca241a5729dbb74fc7e06faa504cc2b17f9d0a968c94dc6fa"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10996"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10996""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-015_2edcb69f771d	MetaCyc:RXN-10996	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:CO-A|MetaCyc:RXN-10996		"[{""reference_id"": ""MetaCyc:RXN-10996"", ""source_assertion"": ""The native right side assigns CO-A with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-10996\""]/right[Compound/@frameid=\""CO-A\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:CO-A"", ""source_assertion"": ""The source CO-A CML structure and InChI specify the selected chemical charge and stereochemical form."", ""source_locator"": ""Compound[@frameid=\""CO-A\""]/cml/molecule/@formalCharge; cml/molecule/formula; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:57287 independently has the same full InChI as native CO-A, including charge and any specified stereochemistry."", ""source_locator"": ""statements[subject=\""CHEBI:57287\"",predicate=\""chemrof:inchi_string\""]; chemrof:generalized_empirical_formula; chemrof:charge""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers the complete original uncompressed Semantic SQL database; selected term locators identify each cited chemical"", ""title"": ""ChEBI exact chemical structures and ionic forms"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:CO-A"", ""source_sha256"": ""a3caac48cbbfe4de6d3156f81b553012a65605df6e3709f6812ab5835a533307"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CO-A"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CO-A""}, {""id"": ""MetaCyc:RXN-10996"", ""source_sha256"": ""d21cd0a6068731fca241a5729dbb74fc7e06faa504cc2b17f9d0a968c94dc6fa"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10996"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10996""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-016_3f8b5a5124c4	MetaCyc:CPD-11953	pathwaymech:consumes	MetaCyc:RXN-10999	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-11953|MetaCyc:RXN-10999		"[{""reference_id"": ""MetaCyc:RXN-10999"", ""source_assertion"": ""The native left side assigns CPD-11953 with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-10999\""]/left[Compound/@frameid=\""CPD-11953\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:CPD-11953"", ""source_assertion"": ""The independently issued native compound preserves its CML structure and ionic form; stale external chemical cross-references are not treated as exact equivalence."", ""source_locator"": ""Compound[@frameid=\""CPD-11953\""]/cml/molecule; inchi; dblink""}]"	"[{""id"": ""MetaCyc:CPD-11953"", ""source_sha256"": ""0c904cb264cfed4e678ec9a35545682ba6909fd6bb012fa197280989b42ccb6b"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CPD-11953"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-11953""}, {""id"": ""MetaCyc:RXN-10999"", ""source_sha256"": ""c101e3b2d91dce9c0887c88c126048467e98d527635cebbedfef7777f7c66726"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10999"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10999""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-017_a8d17fbcf7cb	CHEBI:57288	pathwaymech:consumes	MetaCyc:RXN-10999	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:ACETYL-COA|MetaCyc:RXN-10999		"[{""reference_id"": ""MetaCyc:RXN-10999"", ""source_assertion"": ""The native left side assigns ACETYL-COA with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-10999\""]/left[Compound/@frameid=\""ACETYL-COA\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:ACETYL-COA"", ""source_assertion"": ""The source ACETYL-COA CML structure and InChI specify the selected chemical charge and stereochemical form."", ""source_locator"": ""Compound[@frameid=\""ACETYL-COA\""]/cml/molecule/@formalCharge; cml/molecule/formula; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:57288 independently has the same full InChI as native ACETYL-COA, including charge and any specified stereochemistry."", ""source_locator"": ""statements[subject=\""CHEBI:57288\"",predicate=\""chemrof:inchi_string\""]; chemrof:generalized_empirical_formula; chemrof:charge""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers the complete original uncompressed Semantic SQL database; selected term locators identify each cited chemical"", ""title"": ""ChEBI exact chemical structures and ionic forms"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:ACETYL-COA"", ""source_sha256"": ""eac54e35abb0efbcb4856ee6742432a838f9b11da0499221416c21885be898d5"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native ACETYL-COA"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ACETYL-COA""}, {""id"": ""MetaCyc:RXN-10999"", ""source_sha256"": ""c101e3b2d91dce9c0887c88c126048467e98d527635cebbedfef7777f7c66726"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10999"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10999""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-018_a0f5ef2031b2	MetaCyc:RXN-10999	pathwaymech:produces	MetaCyc:CPD-11959	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-11959|MetaCyc:RXN-10999		"[{""reference_id"": ""MetaCyc:RXN-10999"", ""source_assertion"": ""The native right side assigns CPD-11959 with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-10999\""]/right[Compound/@frameid=\""CPD-11959\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:CPD-11959"", ""source_assertion"": ""The independently issued native compound preserves its CML structure and ionic form; stale external chemical cross-references are not treated as exact equivalence."", ""source_locator"": ""Compound[@frameid=\""CPD-11959\""]/cml/molecule; inchi; dblink""}]"	"[{""id"": ""MetaCyc:CPD-11959"", ""source_sha256"": ""2580b0c693c72b08ce08856ba30800ef97a9a39862bf3a3bf2746d81bb2efaeb"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CPD-11959"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-11959""}, {""id"": ""MetaCyc:RXN-10999"", ""source_sha256"": ""c101e3b2d91dce9c0887c88c126048467e98d527635cebbedfef7777f7c66726"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10999"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10999""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-019_f808a4dc2dec	MetaCyc:RXN-10999	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:CO-A|MetaCyc:RXN-10999		"[{""reference_id"": ""MetaCyc:RXN-10999"", ""source_assertion"": ""The native right side assigns CO-A with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-10999\""]/right[Compound/@frameid=\""CO-A\""]; coefficient (absent means 1)""}, {""reference_id"": ""MetaCyc:CO-A"", ""source_assertion"": ""The source CO-A CML structure and InChI specify the selected chemical charge and stereochemical form."", ""source_locator"": ""Compound[@frameid=\""CO-A\""]/cml/molecule/@formalCharge; cml/molecule/formula; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:57287 independently has the same full InChI as native CO-A, including charge and any specified stereochemistry."", ""source_locator"": ""statements[subject=\""CHEBI:57287\"",predicate=\""chemrof:inchi_string\""]; chemrof:generalized_empirical_formula; chemrof:charge""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers the complete original uncompressed Semantic SQL database; selected term locators identify each cited chemical"", ""title"": ""ChEBI exact chemical structures and ionic forms"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:CO-A"", ""source_sha256"": ""a3caac48cbbfe4de6d3156f81b553012a65605df6e3709f6812ab5835a533307"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CO-A"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CO-A""}, {""id"": ""MetaCyc:RXN-10999"", ""source_sha256"": ""c101e3b2d91dce9c0887c88c126048467e98d527635cebbedfef7777f7c66726"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10999"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10999""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-020_9612b2633ba5	MetaCyc:CPD-11955	pathwaymech:consumes	MetaCyc:RXN-11001	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-11955|MetaCyc:RXN-11001|PMID:37207292|PMID:42630954	RXN-11001 retains the source-issued complete organic transformation. Primary-supported successive adenylations imply two ATP, two AMP, two diphosphate and two H+ with no net water in the selected ionic forms. Native MetaCyc and KEGG instead encode one ATP and water. This is an explicit curated coefficient correction, not exact native-equation equivalence or a measured ATP/product coupling ratio.	"[{""reference_id"": ""MetaCyc:RXN-11001"", ""source_assertion"": ""The native left side assigns CPD-11955 with coefficient 2."", ""source_locator"": ""Reaction[@frameid=\""RXN-11001\""]/left[Compound/@frameid=\""CPD-11955\""]; coefficient (absent means 1)""}, {""reference_id"": ""PMID:37207292"", ""source_assertion"": ""The complete organic assembly combines two HSC and one HAC. Figure 4 uses two successive ATP-dependent adenylation/condensation cycles; the curated net left coefficient for CPD-11955 is 2."", ""source_locator"": ""Original author manuscript Figure 3 p.11; Figure 4 p.12; Results/discussion pp.3–5""}, {""reference_id"": ""PMID:42630954"", ""source_assertion"": ""The updated model describes formation of HSC-HSC-AMP after the first condensation, followed by HAC capping to form B; the co-substrate coefficients are derived from two cycles, not a measured coupling ratio."", ""source_locator"": ""PMC13495013 body/sec[@id=\""sec1\""]/p[3]; body/sec[@id=\""sec3\""]/p[5]""}, {""reference_id"": ""MetaCyc:CPD-11955"", ""source_assertion"": ""The independently issued native compound preserves its CML structure and ionic form; stale external chemical cross-references are not treated as exact equivalence."", ""source_locator"": ""Compound[@frameid=\""CPD-11955\""]/cml/molecule; inchi; dblink""}]"	"[{""id"": ""MetaCyc:CPD-11955"", ""source_sha256"": ""5197d2b33565fbf0f0628000ff0de41724b9c6f86cbc2cafb18ea00b99a370db"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CPD-11955"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-11955""}, {""id"": ""MetaCyc:RXN-11001"", ""source_sha256"": ""3a4abb007c7bb06ec55603c9e732cb1eb6540f31f828c98bdf1b78cdb62216e9"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-11001"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11001""}, {""id"": ""PMID:37207292"", ""source_sha256"": ""8f72641f62e460e677aa6d1a582c968ff93b89fcc24b487bb8dd2aa0ac1bfa9a"", ""source_version"": ""Original NSF-hosted author manuscript PDF; retrieved 2026-10-11"", ""title"": ""Siderophore Synthetase DesD Catalyzes N-to-C Condensation in Desferrioxamine Biosynthesis"", ""url"": ""https://par.nsf.gov/servlets/purl/10505308""}, {""id"": ""PMID:42630954"", ""source_sha256"": ""a015d255b9ff76a5967be70c2f722e86b00e69d2b11b2df338d437812ebe3a99"", ""source_version"": ""Original complete primary JATS XML retrieved 2026-10-11"", ""title"": ""Modular Inhibitor Approach to Map the Catalytic Trajectory of an Iterative Siderophore Synthetase, DesD"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13495013/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-021_a29c1ddba56b	MetaCyc:CPD-11959	pathwaymech:consumes	MetaCyc:RXN-11001	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-11959|MetaCyc:RXN-11001|PMID:37207292|PMID:42630954	RXN-11001 retains the source-issued complete organic transformation. Primary-supported successive adenylations imply two ATP, two AMP, two diphosphate and two H+ with no net water in the selected ionic forms. Native MetaCyc and KEGG instead encode one ATP and water. This is an explicit curated coefficient correction, not exact native-equation equivalence or a measured ATP/product coupling ratio.	"[{""reference_id"": ""MetaCyc:RXN-11001"", ""source_assertion"": ""The native left side assigns CPD-11959 with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-11001\""]/left[Compound/@frameid=\""CPD-11959\""]; coefficient (absent means 1)""}, {""reference_id"": ""PMID:37207292"", ""source_assertion"": ""The complete organic assembly combines two HSC and one HAC. Figure 4 uses two successive ATP-dependent adenylation/condensation cycles; the curated net left coefficient for CPD-11959 is 1."", ""source_locator"": ""Original author manuscript Figure 3 p.11; Figure 4 p.12; Results/discussion pp.3–5""}, {""reference_id"": ""PMID:42630954"", ""source_assertion"": ""The updated model describes formation of HSC-HSC-AMP after the first condensation, followed by HAC capping to form B; the co-substrate coefficients are derived from two cycles, not a measured coupling ratio."", ""source_locator"": ""PMC13495013 body/sec[@id=\""sec1\""]/p[3]; body/sec[@id=\""sec3\""]/p[5]""}, {""reference_id"": ""MetaCyc:CPD-11959"", ""source_assertion"": ""The independently issued native compound preserves its CML structure and ionic form; stale external chemical cross-references are not treated as exact equivalence."", ""source_locator"": ""Compound[@frameid=\""CPD-11959\""]/cml/molecule; inchi; dblink""}]"	"[{""id"": ""MetaCyc:CPD-11959"", ""source_sha256"": ""2580b0c693c72b08ce08856ba30800ef97a9a39862bf3a3bf2746d81bb2efaeb"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CPD-11959"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-11959""}, {""id"": ""MetaCyc:RXN-11001"", ""source_sha256"": ""3a4abb007c7bb06ec55603c9e732cb1eb6540f31f828c98bdf1b78cdb62216e9"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-11001"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11001""}, {""id"": ""PMID:37207292"", ""source_sha256"": ""8f72641f62e460e677aa6d1a582c968ff93b89fcc24b487bb8dd2aa0ac1bfa9a"", ""source_version"": ""Original NSF-hosted author manuscript PDF; retrieved 2026-10-11"", ""title"": ""Siderophore Synthetase DesD Catalyzes N-to-C Condensation in Desferrioxamine Biosynthesis"", ""url"": ""https://par.nsf.gov/servlets/purl/10505308""}, {""id"": ""PMID:42630954"", ""source_sha256"": ""a015d255b9ff76a5967be70c2f722e86b00e69d2b11b2df338d437812ebe3a99"", ""source_version"": ""Original complete primary JATS XML retrieved 2026-10-11"", ""title"": ""Modular Inhibitor Approach to Map the Catalytic Trajectory of an Iterative Siderophore Synthetase, DesD"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13495013/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-022_00108012d86b	CHEBI:30616	pathwaymech:consumes	MetaCyc:RXN-11001	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:ATP|MetaCyc:RXN-11001|PMID:37207292|PMID:42630954	RXN-11001 retains the source-issued complete organic transformation. Primary-supported successive adenylations imply two ATP, two AMP, two diphosphate and two H+ with no net water in the selected ionic forms. Native MetaCyc and KEGG instead encode one ATP and water. This is an explicit curated coefficient correction, not exact native-equation equivalence or a measured ATP/product coupling ratio.	"[{""reference_id"": ""MetaCyc:RXN-11001"", ""source_assertion"": ""The native left side assigns ATP with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-11001\""]/left[Compound/@frameid=\""ATP\""]; coefficient (absent means 1)""}, {""reference_id"": ""PMID:37207292"", ""source_assertion"": ""The complete organic assembly combines two HSC and one HAC. Figure 4 uses two successive ATP-dependent adenylation/condensation cycles; the curated net left coefficient for ATP is 2."", ""source_locator"": ""Original author manuscript Figure 3 p.11; Figure 4 p.12; Results/discussion pp.3–5""}, {""reference_id"": ""PMID:42630954"", ""source_assertion"": ""The updated model describes formation of HSC-HSC-AMP after the first condensation, followed by HAC capping to form B; the co-substrate coefficients are derived from two cycles, not a measured coupling ratio."", ""source_locator"": ""PMC13495013 body/sec[@id=\""sec1\""]/p[3]; body/sec[@id=\""sec3\""]/p[5]""}, {""reference_id"": ""MetaCyc:ATP"", ""source_assertion"": ""The source ATP CML structure and InChI specify the selected chemical charge and stereochemical form."", ""source_locator"": ""Compound[@frameid=\""ATP\""]/cml/molecule/@formalCharge; cml/molecule/formula; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:30616 independently has the same full InChI as native ATP, including charge and any specified stereochemistry."", ""source_locator"": ""statements[subject=\""CHEBI:30616\"",predicate=\""chemrof:inchi_string\""]; chemrof:generalized_empirical_formula; chemrof:charge""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers the complete original uncompressed Semantic SQL database; selected term locators identify each cited chemical"", ""title"": ""ChEBI exact chemical structures and ionic forms"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:ATP"", ""source_sha256"": ""bb03bc7d49a62af159cb0563a5b5a58e655787bb44290cf682b4a723a2d93f50"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native ATP"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ATP""}, {""id"": ""MetaCyc:RXN-11001"", ""source_sha256"": ""3a4abb007c7bb06ec55603c9e732cb1eb6540f31f828c98bdf1b78cdb62216e9"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-11001"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11001""}, {""id"": ""PMID:37207292"", ""source_sha256"": ""8f72641f62e460e677aa6d1a582c968ff93b89fcc24b487bb8dd2aa0ac1bfa9a"", ""source_version"": ""Original NSF-hosted author manuscript PDF; retrieved 2026-10-11"", ""title"": ""Siderophore Synthetase DesD Catalyzes N-to-C Condensation in Desferrioxamine Biosynthesis"", ""url"": ""https://par.nsf.gov/servlets/purl/10505308""}, {""id"": ""PMID:42630954"", ""source_sha256"": ""a015d255b9ff76a5967be70c2f722e86b00e69d2b11b2df338d437812ebe3a99"", ""source_version"": ""Original complete primary JATS XML retrieved 2026-10-11"", ""title"": ""Modular Inhibitor Approach to Map the Catalytic Trajectory of an Iterative Siderophore Synthetase, DesD"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13495013/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-023_28e31f216e33	MetaCyc:RXN-11001	pathwaymech:produces	MetaCyc:CPD-3764	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-3764|MetaCyc:RXN-11001|PMID:37207292|PMID:42630954	RXN-11001 retains the source-issued complete organic transformation. Primary-supported successive adenylations imply two ATP, two AMP, two diphosphate and two H+ with no net water in the selected ionic forms. Native MetaCyc and KEGG instead encode one ATP and water. This is an explicit curated coefficient correction, not exact native-equation equivalence or a measured ATP/product coupling ratio.	"[{""reference_id"": ""MetaCyc:RXN-11001"", ""source_assertion"": ""The native right side assigns CPD-3764 with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-11001\""]/right[Compound/@frameid=\""CPD-3764\""]; coefficient (absent means 1)""}, {""reference_id"": ""PMID:37207292"", ""source_assertion"": ""The complete organic assembly combines two HSC and one HAC. Figure 4 uses two successive ATP-dependent adenylation/condensation cycles; the curated net right coefficient for CPD-3764 is 1."", ""source_locator"": ""Original author manuscript Figure 3 p.11; Figure 4 p.12; Results/discussion pp.3–5""}, {""reference_id"": ""PMID:42630954"", ""source_assertion"": ""The updated model describes formation of HSC-HSC-AMP after the first condensation, followed by HAC capping to form B; the co-substrate coefficients are derived from two cycles, not a measured coupling ratio."", ""source_locator"": ""PMC13495013 body/sec[@id=\""sec1\""]/p[3]; body/sec[@id=\""sec3\""]/p[5]""}, {""reference_id"": ""MetaCyc:CPD-3764"", ""source_assertion"": ""The independently issued native compound preserves its CML structure and ionic form; stale external chemical cross-references are not treated as exact equivalence."", ""source_locator"": ""Compound[@frameid=\""CPD-3764\""]/cml/molecule; inchi; dblink""}]"	"[{""id"": ""MetaCyc:CPD-3764"", ""source_sha256"": ""0d03bd8aec8aedc34adf9ba87279d6570e323643275e51f1d3f27f9cf922de21"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CPD-3764"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-3764""}, {""id"": ""MetaCyc:RXN-11001"", ""source_sha256"": ""3a4abb007c7bb06ec55603c9e732cb1eb6540f31f828c98bdf1b78cdb62216e9"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-11001"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11001""}, {""id"": ""PMID:37207292"", ""source_sha256"": ""8f72641f62e460e677aa6d1a582c968ff93b89fcc24b487bb8dd2aa0ac1bfa9a"", ""source_version"": ""Original NSF-hosted author manuscript PDF; retrieved 2026-10-11"", ""title"": ""Siderophore Synthetase DesD Catalyzes N-to-C Condensation in Desferrioxamine Biosynthesis"", ""url"": ""https://par.nsf.gov/servlets/purl/10505308""}, {""id"": ""PMID:42630954"", ""source_sha256"": ""a015d255b9ff76a5967be70c2f722e86b00e69d2b11b2df338d437812ebe3a99"", ""source_version"": ""Original complete primary JATS XML retrieved 2026-10-11"", ""title"": ""Modular Inhibitor Approach to Map the Catalytic Trajectory of an Iterative Siderophore Synthetase, DesD"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13495013/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-024_fe3a51eb8f68	MetaCyc:RXN-11001	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:AMP|MetaCyc:RXN-11001|PMID:37207292|PMID:42630954	RXN-11001 retains the source-issued complete organic transformation. Primary-supported successive adenylations imply two ATP, two AMP, two diphosphate and two H+ with no net water in the selected ionic forms. Native MetaCyc and KEGG instead encode one ATP and water. This is an explicit curated coefficient correction, not exact native-equation equivalence or a measured ATP/product coupling ratio.	"[{""reference_id"": ""MetaCyc:RXN-11001"", ""source_assertion"": ""The native right side assigns AMP with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-11001\""]/right[Compound/@frameid=\""AMP\""]; coefficient (absent means 1)""}, {""reference_id"": ""PMID:37207292"", ""source_assertion"": ""The complete organic assembly combines two HSC and one HAC. Figure 4 uses two successive ATP-dependent adenylation/condensation cycles; the curated net right coefficient for AMP is 2."", ""source_locator"": ""Original author manuscript Figure 3 p.11; Figure 4 p.12; Results/discussion pp.3–5""}, {""reference_id"": ""PMID:42630954"", ""source_assertion"": ""The updated model describes formation of HSC-HSC-AMP after the first condensation, followed by HAC capping to form B; the co-substrate coefficients are derived from two cycles, not a measured coupling ratio."", ""source_locator"": ""PMC13495013 body/sec[@id=\""sec1\""]/p[3]; body/sec[@id=\""sec3\""]/p[5]""}, {""reference_id"": ""MetaCyc:AMP"", ""source_assertion"": ""The source AMP CML structure and InChI specify the selected chemical charge and stereochemical form."", ""source_locator"": ""Compound[@frameid=\""AMP\""]/cml/molecule/@formalCharge; cml/molecule/formula; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:456215 independently has the same full InChI as native AMP, including charge and any specified stereochemistry."", ""source_locator"": ""statements[subject=\""CHEBI:456215\"",predicate=\""chemrof:inchi_string\""]; chemrof:generalized_empirical_formula; chemrof:charge""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers the complete original uncompressed Semantic SQL database; selected term locators identify each cited chemical"", ""title"": ""ChEBI exact chemical structures and ionic forms"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:AMP"", ""source_sha256"": ""f4de874fe3fd147827332ac5f9544e83b533d99e1141ba599a73ac9853f65a62"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native AMP"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:AMP""}, {""id"": ""MetaCyc:RXN-11001"", ""source_sha256"": ""3a4abb007c7bb06ec55603c9e732cb1eb6540f31f828c98bdf1b78cdb62216e9"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-11001"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11001""}, {""id"": ""PMID:37207292"", ""source_sha256"": ""8f72641f62e460e677aa6d1a582c968ff93b89fcc24b487bb8dd2aa0ac1bfa9a"", ""source_version"": ""Original NSF-hosted author manuscript PDF; retrieved 2026-10-11"", ""title"": ""Siderophore Synthetase DesD Catalyzes N-to-C Condensation in Desferrioxamine Biosynthesis"", ""url"": ""https://par.nsf.gov/servlets/purl/10505308""}, {""id"": ""PMID:42630954"", ""source_sha256"": ""a015d255b9ff76a5967be70c2f722e86b00e69d2b11b2df338d437812ebe3a99"", ""source_version"": ""Original complete primary JATS XML retrieved 2026-10-11"", ""title"": ""Modular Inhibitor Approach to Map the Catalytic Trajectory of an Iterative Siderophore Synthetase, DesD"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13495013/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-025_333afaaec54a	MetaCyc:RXN-11001	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:PPI|MetaCyc:RXN-11001|PMID:37207292|PMID:42630954	RXN-11001 retains the source-issued complete organic transformation. Primary-supported successive adenylations imply two ATP, two AMP, two diphosphate and two H+ with no net water in the selected ionic forms. Native MetaCyc and KEGG instead encode one ATP and water. This is an explicit curated coefficient correction, not exact native-equation equivalence or a measured ATP/product coupling ratio.	"[{""reference_id"": ""MetaCyc:RXN-11001"", ""source_assertion"": ""The native right side assigns PPI with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-11001\""]/right[Compound/@frameid=\""PPI\""]; coefficient (absent means 1)""}, {""reference_id"": ""PMID:37207292"", ""source_assertion"": ""The complete organic assembly combines two HSC and one HAC. Figure 4 uses two successive ATP-dependent adenylation/condensation cycles; the curated net right coefficient for PPI is 2."", ""source_locator"": ""Original author manuscript Figure 3 p.11; Figure 4 p.12; Results/discussion pp.3–5""}, {""reference_id"": ""PMID:42630954"", ""source_assertion"": ""The updated model describes formation of HSC-HSC-AMP after the first condensation, followed by HAC capping to form B; the co-substrate coefficients are derived from two cycles, not a measured coupling ratio."", ""source_locator"": ""PMC13495013 body/sec[@id=\""sec1\""]/p[3]; body/sec[@id=\""sec3\""]/p[5]""}, {""reference_id"": ""MetaCyc:PPI"", ""source_assertion"": ""The source PPI CML structure and InChI specify the selected chemical charge and stereochemical form."", ""source_locator"": ""Compound[@frameid=\""PPI\""]/cml/molecule/@formalCharge; cml/molecule/formula; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:33019 independently has the same full InChI as native PPI, including charge and any specified stereochemistry."", ""source_locator"": ""statements[subject=\""CHEBI:33019\"",predicate=\""chemrof:inchi_string\""]; chemrof:generalized_empirical_formula; chemrof:charge""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers the complete original uncompressed Semantic SQL database; selected term locators identify each cited chemical"", ""title"": ""ChEBI exact chemical structures and ionic forms"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:PPI"", ""source_sha256"": ""9e6257dbc2e18b5c475d4a546eef842e55dd1432dbdada4d0a88d22c381aede9"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PPI"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PPI""}, {""id"": ""MetaCyc:RXN-11001"", ""source_sha256"": ""3a4abb007c7bb06ec55603c9e732cb1eb6540f31f828c98bdf1b78cdb62216e9"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-11001"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11001""}, {""id"": ""PMID:37207292"", ""source_sha256"": ""8f72641f62e460e677aa6d1a582c968ff93b89fcc24b487bb8dd2aa0ac1bfa9a"", ""source_version"": ""Original NSF-hosted author manuscript PDF; retrieved 2026-10-11"", ""title"": ""Siderophore Synthetase DesD Catalyzes N-to-C Condensation in Desferrioxamine Biosynthesis"", ""url"": ""https://par.nsf.gov/servlets/purl/10505308""}, {""id"": ""PMID:42630954"", ""source_sha256"": ""a015d255b9ff76a5967be70c2f722e86b00e69d2b11b2df338d437812ebe3a99"", ""source_version"": ""Original complete primary JATS XML retrieved 2026-10-11"", ""title"": ""Modular Inhibitor Approach to Map the Catalytic Trajectory of an Iterative Siderophore Synthetase, DesD"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13495013/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-026_6cd6d0754e8c	MetaCyc:RXN-11001	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:PROTON|MetaCyc:RXN-11001|PMID:37207292|PMID:42630954	RXN-11001 retains the source-issued complete organic transformation. Primary-supported successive adenylations imply two ATP, two AMP, two diphosphate and two H+ with no net water in the selected ionic forms. Native MetaCyc and KEGG instead encode one ATP and water. This is an explicit curated coefficient correction, not exact native-equation equivalence or a measured ATP/product coupling ratio.	"[{""reference_id"": ""MetaCyc:RXN-11001"", ""source_assertion"": ""The native right side assigns PROTON with coefficient 1."", ""source_locator"": ""Reaction[@frameid=\""RXN-11001\""]/right[Compound/@frameid=\""PROTON\""]; coefficient (absent means 1)""}, {""reference_id"": ""PMID:37207292"", ""source_assertion"": ""The complete organic assembly combines two HSC and one HAC. Figure 4 uses two successive ATP-dependent adenylation/condensation cycles; the curated net right coefficient for PROTON is 2."", ""source_locator"": ""Original author manuscript Figure 3 p.11; Figure 4 p.12; Results/discussion pp.3–5""}, {""reference_id"": ""PMID:42630954"", ""source_assertion"": ""The updated model describes formation of HSC-HSC-AMP after the first condensation, followed by HAC capping to form B; the co-substrate coefficients are derived from two cycles, not a measured coupling ratio."", ""source_locator"": ""PMC13495013 body/sec[@id=\""sec1\""]/p[3]; body/sec[@id=\""sec3\""]/p[5]""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The source PROTON CML structure and InChI specify the selected chemical charge and stereochemical form."", ""source_locator"": ""Compound[@frameid=\""PROTON\""]/cml/molecule/@formalCharge; cml/molecule/formula; inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:15378 independently has the same full InChI as native PROTON, including charge and any specified stereochemistry."", ""source_locator"": ""statements[subject=\""CHEBI:15378\"",predicate=\""chemrof:inchi_string\""]; chemrof:generalized_empirical_formula; chemrof:charge""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers the complete original uncompressed Semantic SQL database; selected term locators identify each cited chemical"", ""title"": ""ChEBI exact chemical structures and ionic forms"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PROTON"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}, {""id"": ""MetaCyc:RXN-11001"", ""source_sha256"": ""3a4abb007c7bb06ec55603c9e732cb1eb6540f31f828c98bdf1b78cdb62216e9"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-11001"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11001""}, {""id"": ""PMID:37207292"", ""source_sha256"": ""8f72641f62e460e677aa6d1a582c968ff93b89fcc24b487bb8dd2aa0ac1bfa9a"", ""source_version"": ""Original NSF-hosted author manuscript PDF; retrieved 2026-10-11"", ""title"": ""Siderophore Synthetase DesD Catalyzes N-to-C Condensation in Desferrioxamine Biosynthesis"", ""url"": ""https://par.nsf.gov/servlets/purl/10505308""}, {""id"": ""PMID:42630954"", ""source_sha256"": ""a015d255b9ff76a5967be70c2f722e86b00e69d2b11b2df338d437812ebe3a99"", ""source_version"": ""Original complete primary JATS XML retrieved 2026-10-11"", ""title"": ""Modular Inhibitor Approach to Map the Catalytic Trajectory of an Iterative Siderophore Synthetase, DesD"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13495013/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-027_3b0d0284ca2f	MetaCyc:SCO2782-MONOMER	pathwaymech:enables	MetaCyc:LYSDECARBOX-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:SCO2782-MONOMER|PMID:22906379	DesA gene-product activity is supported by the original coelicolor biochemical abstract and native annotation. Whole-cluster complementation is not proof of isolated monomer sufficiency; the original 2012 full methods were not inspected.	"[{""reference_id"": ""MetaCyc:SCO2782-MONOMER"", ""source_assertion"": ""The native SCO2782/desA object identifies lysine decarboxylase in coelicolor A3(2); deletion and whole-cluster complementation support pathway involvement."", ""source_locator"": ""Protein/catalyzes/Enzymatic-Reaction[@frameid=\""ENZRXN-17211\""]; gene; comment""}, {""reference_id"": ""PMID:22906379"", ""source_assertion"": ""The original abstract directly reports that S. coelicolor desA encodes a lysine decarboxylase, distinct from the formerly predicted diaminobutyrate activity."", ""source_locator"": ""PubmedArticle/MedlineCitation/Article/Abstract""}]"	"[{""id"": ""MetaCyc:SCO2782-MONOMER"", ""source_sha256"": ""6c1352618b665bc70876525504761b31c01cfc05f4d6491c5bf2f4a4185e3805"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native SCO2782-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:SCO2782-MONOMER""}, {""id"": ""PMID:22906379"", ""source_sha256"": ""1aaa2e3574b41d9b21f9e629ecce18de0134b67f9474e8854a21ad5b7f96c048"", ""source_version"": ""Original PubMed indexed abstract only; retrieved 2026-10-11"", ""title"": ""Evolution of a novel lysine decarboxylase in siderophore biosynthesis."", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=22906379&retmode=xml""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-028_78ce38b8ab52	MetaCyc:SCO2783-MONOMER	pathwaymech:enables	MetaCyc:RXN-10995	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:SCO2783-MONOMER|PMID:33784308|UniProtKB:Q9L071	This enables relation preserves a proposed native coelicolor gene-product assignment, not an experimentally established isolated activity. The native reaction retains generic reduced/oxidized electron-acceptor classes. It does not identify a specific physiological coelicolor donor. The S. sviceus NADPH/NADH experiments and the sequence-unmatched 2023 DesABC preparation do not establish donor specificity for this exact coelicolor protein.	"[{""reference_id"": ""MetaCyc:SCO2783-MONOMER"", ""source_assertion"": ""SCO2783/desB is natively assigned the proposed cadaverine-hydroxylase step; the comment explicitly states that this coelicolor protein had not been purified or biochemically characterized."", ""source_locator"": ""Protein/catalyzes/Enzymatic-Reaction[@frameid=\""ENZRXN-17212\""]; gene; comment""}, {""reference_id"": ""PMID:33784308"", ""source_assertion"": ""The directly characterized enzyme is S. sviceus SSEG_08523, expressed with a His tag. Its NADPH/NADH kinetics, FAD and tetramer observations are cross-species context, not direct coelicolor evidence."", ""source_locator"": ""PMC8009421 Methods/sec[@id=\""sec003\""]/p[1]; cloning sec[@id=\""sec011\""]/p[1]; Results and Discussion""}, {""reference_id"": ""UniProtKB:Q9L071"", ""source_assertion"": ""The current entry explicitly cross-identifies SCO2783/desB but automatically assigns MbtG lysine-hydroxylase function. That substrate/function transfer is not adopted for this native cadaverine pathway."", ""source_locator"": ""results[primaryAccession=\""Q9L071\""]/genes; proteinDescription; comments[commentType=\""CATALYTIC ACTIVITY\""]; evidence ECO:0000256""}]"	"[{""id"": ""MetaCyc:SCO2783-MONOMER"", ""source_sha256"": ""753135fe55cddbc1749e9dd9499cb24ea379bd91121f6dbf2d38a605698cffea"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native SCO2783-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:SCO2783-MONOMER""}, {""id"": ""PMID:33784308"", ""source_sha256"": ""65eff35c4cf612dc2cba832e64932c93ef3653471f4d755ef7417da4f203c9bb"", ""source_version"": ""Original complete primary JATS XML retrieved 2026-10-11"", ""title"": ""Characterization of a broadly specific cadaverine N-hydroxylase involved in desferrioxamine B biosynthesis in Streptomyces sviceus"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8009421/fullTextXML""}, {""id"": ""UniProtKB:Q9L071"", ""source_sha256"": ""40f49d3bc21c6eb581891fae186b79c96851ed1a339c62bf418ebeba4c5f0905"", ""source_version"": ""UniProtKB 2026_03; complete original four-entry search batch retrieved 2026-10-11; unreviewed entries"", ""title"": ""UniProtKB Q9L071 complete current native entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28gene_exact%3AdesA+OR+gene_exact%3AdesB+OR+gene_exact%3AdesC+OR+gene_exact%3AdesD%29+AND+organism_id%3A100226&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-029_c5c9453f0deb	MetaCyc:SCO2784-MONOMER	pathwaymech:enables	MetaCyc:RXN-10996	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.6084/m9.figshare.5965882.v2|MetaCyc:SCO2784-MONOMER|PMID:29685972|UniProtKB:Q9L070	Directly tested in a M145-derived N-terminal His6 preparation. Gel filtration supports a monomer for that preparation, not all conditions. The published primers and locus bridge are preserved; the supplement’s 517-bp gene length differs from the current full entry, so exact complete construct equality is not asserted.	"[{""reference_id"": ""MetaCyc:SCO2784-MONOMER"", ""source_assertion"": ""The native object identifies SCO2784/desC and UniProt Q9L070; its old uncharacterized annotation predates the direct 2018 DesC experiments."", ""source_locator"": ""Protein/gene; dblink[dblink-db=\""UNIPROT\""]; comment""}, {""reference_id"": ""PMID:29685972"", ""source_assertion"": ""Purified tagged DesC from coelicolor catalyzed N-hydroxycadaverine acylation with succinyl-CoA, giving the corresponding authentic-standard-matched product and CoA."", ""source_locator"": ""PMC5915712 section[@id=\""s2a\""] (Results and discussion §2(a)); figure[@id=\""RSTB20170068F4\""] panel a; separately cited original supplement §1.6.1 and §1.7""}, {""reference_id"": ""DOI:10.6084/m9.figshare.5965882.v2"", ""source_assertion"": ""The gene was cloned from S. coelicolor M145 genomic DNA. Section 1.6.1 reports the succinyl-CoA assay and authentic-standard LC-MS/MS comparison; section1.7 supports CoA formation."", ""source_locator"": ""Original DOC §1.3; §1.6.1; §1.7""}, {""reference_id"": ""UniProtKB:Q9L070"", ""source_assertion"": ""Q9L070 cross-identifies SCO2784/desC but its automatic MbtK/mycobactin assignment conflicts with the directly measured cadaverine acylation and is not used as pathway evidence."", ""source_locator"": ""results[primaryAccession=\""Q9L070\""]/genes; proteinDescription; comments[commentType=\""FUNCTION\""]""}]"	"[{""id"": ""DOI:10.6084/m9.figshare.5965882.v2"", ""source_sha256"": ""78add31499240881314a6a9a068691b9ad7fbd5eec93c5ec0bf3a314988611d3"", ""source_version"": ""Original Royal Society Figshare version2 CDFV2 DOC; collection4027009/article5965882/file10912295; retrieved 2026-10-11"", ""title"": ""Supplementary Material: Desferrioxamine biosynthesis: Diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC"", ""url"": ""https://ndownloader.figshare.com/files/10912295""}, {""id"": ""MetaCyc:SCO2784-MONOMER"", ""source_sha256"": ""9856a1077ca516a7cfc5c7037e69cb261688ad16306ccc268b39496b2e572879"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native SCO2784-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:SCO2784-MONOMER""}, {""id"": ""PMID:29685972"", ""source_sha256"": ""1bd6c3e3a9a9048f03545ede3a17af2a8de138f070acc00827cec61ac5d557f3"", ""source_version"": ""Original full primary HTML retrieved 2026-10-11"", ""title"": ""Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC5915712/""}, {""id"": ""UniProtKB:Q9L070"", ""source_sha256"": ""40f49d3bc21c6eb581891fae186b79c96851ed1a339c62bf418ebeba4c5f0905"", ""source_version"": ""UniProtKB 2026_03; complete original four-entry search batch retrieved 2026-10-11; unreviewed entries"", ""title"": ""UniProtKB Q9L070 complete current native entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28gene_exact%3AdesA+OR+gene_exact%3AdesB+OR+gene_exact%3AdesC+OR+gene_exact%3AdesD%29+AND+organism_id%3A100226&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-030_f2768833db30	MetaCyc:SCO2784-MONOMER	pathwaymech:enables	MetaCyc:RXN-10999	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.6084/m9.figshare.5965882.v2|MetaCyc:SCO2784-MONOMER|PMID:29685972|UniProtKB:Q9L070	Directly tested in a M145-derived N-terminal His6 preparation. Gel filtration supports a monomer for that preparation, not all conditions. The published primers and locus bridge are preserved; the supplement’s 517-bp gene length differs from the current full entry, so exact complete construct equality is not asserted.	"[{""reference_id"": ""MetaCyc:SCO2784-MONOMER"", ""source_assertion"": ""The native object identifies SCO2784/desC and UniProt Q9L070; its old uncharacterized annotation predates the direct 2018 DesC experiments."", ""source_locator"": ""Protein/gene; dblink[dblink-db=\""UNIPROT\""]; comment""}, {""reference_id"": ""PMID:29685972"", ""source_assertion"": ""Purified tagged DesC from coelicolor catalyzed N-hydroxycadaverine acylation with acetyl-CoA, giving the corresponding authentic-standard-matched product and CoA."", ""source_locator"": ""PMC5915712 section[@id=\""s2a\""] (Results and discussion §2(a)); figure[@id=\""RSTB20170068F4\""] panel b; separately cited original supplement §1.6.2 and §1.7""}, {""reference_id"": ""DOI:10.6084/m9.figshare.5965882.v2"", ""source_assertion"": ""The gene was cloned from S. coelicolor M145 genomic DNA. Section 1.6.2 reports the acetyl-CoA assay and authentic-standard LC-MS/MS comparison; section1.7 supports CoA formation."", ""source_locator"": ""Original DOC §1.3; §1.6.2; §1.7""}, {""reference_id"": ""UniProtKB:Q9L070"", ""source_assertion"": ""Q9L070 cross-identifies SCO2784/desC but its automatic MbtK/mycobactin assignment conflicts with the directly measured cadaverine acylation and is not used as pathway evidence."", ""source_locator"": ""results[primaryAccession=\""Q9L070\""]/genes; proteinDescription; comments[commentType=\""FUNCTION\""]""}]"	"[{""id"": ""DOI:10.6084/m9.figshare.5965882.v2"", ""source_sha256"": ""78add31499240881314a6a9a068691b9ad7fbd5eec93c5ec0bf3a314988611d3"", ""source_version"": ""Original Royal Society Figshare version2 CDFV2 DOC; collection4027009/article5965882/file10912295; retrieved 2026-10-11"", ""title"": ""Supplementary Material: Desferrioxamine biosynthesis: Diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC"", ""url"": ""https://ndownloader.figshare.com/files/10912295""}, {""id"": ""MetaCyc:SCO2784-MONOMER"", ""source_sha256"": ""9856a1077ca516a7cfc5c7037e69cb261688ad16306ccc268b39496b2e572879"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native SCO2784-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:SCO2784-MONOMER""}, {""id"": ""PMID:29685972"", ""source_sha256"": ""1bd6c3e3a9a9048f03545ede3a17af2a8de138f070acc00827cec61ac5d557f3"", ""source_version"": ""Original full primary HTML retrieved 2026-10-11"", ""title"": ""Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC5915712/""}, {""id"": ""UniProtKB:Q9L070"", ""source_sha256"": ""40f49d3bc21c6eb581891fae186b79c96851ed1a339c62bf418ebeba4c5f0905"", ""source_version"": ""UniProtKB 2026_03; complete original four-entry search batch retrieved 2026-10-11; unreviewed entries"", ""title"": ""UniProtKB Q9L070 complete current native entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28gene_exact%3AdesA+OR+gene_exact%3AdesB+OR+gene_exact%3AdesC+OR+gene_exact%3AdesD%29+AND+organism_id%3A100226&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-031_a2b2a63c6590	MetaCyc:CPLX-7949	pathwaymech:catalyzes	MetaCyc:RXN-11001	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1016/j.jbc.2022.102166|DOI:10.1021/acschembio.3c00167.s001|MetaCyc:CPLX-7949|PMID:37207292	Native coelicolor DesD homodimer with B-forming activity supported by the sequence-grounded ScDesD preparation. Native assignment of dimeric assembly is separate from primary B-product measurement. Assay MgATP does not alone justify an obligatory free-Mg cofactor edge. The cellular control favoring B over G/E remains unresolved. RXN-11001 retains the source-issued complete organic transformation. Primary-supported successive adenylations imply two ATP, two AMP, two diphosphate and two H+ with no net water in the selected ionic forms. Native MetaCyc and KEGG instead encode one ATP and water. This is an explicit curated coefficient correction, not exact native-equation equivalence or a measured ATP/product coupling ratio.	"[{""reference_id"": ""MetaCyc:CPLX-7949"", ""source_assertion"": ""The native coelicolor DesD complex contains two SCO2785-MONOMER subunits and reports dimeric recombinant enzyme; its canonical E-synthetase name does not limit the experimentally observed substrate range."", ""source_locator"": ""Protein/component[Protein/@frameid=\""SCO2785-MONOMER\""]/coefficient; species; comment""}, {""reference_id"": ""PMID:37207292"", ""source_assertion"": ""ScDesD catalyzed formation of B from HSC-HSC plus HAC. The tested HSC plus HSC-HAC combination did not yield detectable B; the proposed cycle requires successive adenylations."", ""source_locator"": ""Original author manuscript Figure 3 p.11; Figure 4 p.12; Results pp.2–4""}, {""reference_id"": ""DOI:10.1016/j.jbc.2022.102166"", ""source_assertion"": ""The coelicolor native DesD sequence in Table S7 and the native core of the His6 construct in Table S9 both exactly match current Q9L069 after removal of the explicitly supplied tag."", ""source_locator"": ""Original mmc1.pdf Table S7 p.S52; Table S9 p.S56; full native/construct sequence comparison""}, {""reference_id"": ""DOI:10.1021/acschembio.3c00167.s001"", ""source_assertion"": ""The DesD ortholog constructs were prepared as reported in the 2022 study; the B-product assay used HSC-HSC plus HAC and ATP/Mg-containing buffer."", ""source_locator"": ""Original supplement p.S7 Protein expression and purification; p.S8 Product formation assay; Table S1 p.S10""}]"	"[{""id"": ""DOI:10.1016/j.jbc.2022.102166"", ""source_sha256"": ""a77346959739a59578f8a492cde02bdd942fc570e7f8654d858ccf7c0779ecba"", ""source_version"": ""Original archive member mmc1.pdf; reference digest covers extracted unchanged PDF; archive digest and extraction receipt in source manifest"", ""title"": ""Supporting Information mmc1.pdf to An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9356276/supplementaryFiles""}, {""id"": ""DOI:10.1021/acschembio.3c00167.s001"", ""source_sha256"": ""3a63baf7a649475c52167f33ecbc8fd01942c53f2d7258566f5af1e564ec8365"", ""source_version"": ""Original ACS Figshare supplement PDF; article22970446/file40713082; retrieved 2026-10-11"", ""title"": ""Supporting Information: Siderophore Synthetase DesD Catalyzes N-to-C Condensation in Desferrioxamine Biosynthesis"", ""url"": ""https://ndownloader.figshare.com/files/40713082""}, {""id"": ""MetaCyc:CPLX-7949"", ""source_sha256"": ""33718d8536034939f699d545bd125cb8301455a9ec34799fb828d31b17a99e2e"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CPLX-7949"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7949""}, {""id"": ""PMID:37207292"", ""source_sha256"": ""8f72641f62e460e677aa6d1a582c968ff93b89fcc24b487bb8dd2aa0ac1bfa9a"", ""source_version"": ""Original NSF-hosted author manuscript PDF; retrieved 2026-10-11"", ""title"": ""Siderophore Synthetase DesD Catalyzes N-to-C Condensation in Desferrioxamine Biosynthesis"", ""url"": ""https://par.nsf.gov/servlets/purl/10505308""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-032_8afd2e8e6262	MetaCyc:LYSDECARBOX-RXN	BFO:0000050	MetaCyc:PWY-6376	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6376		"[{""reference_id"": ""MetaCyc:PWY-6376"", ""source_assertion"": ""The native full B pathway includes LYSDECARBOX-RXN and selects its L2R pathway layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-6376\""]/reaction-list; reaction-layout[Reaction/@frameid=\""LYSDECARBOX-RXN\""]/direction""}]"	"[{""id"": ""MetaCyc:PWY-6376"", ""source_sha256"": ""dae85f1da639c7f6ea757c6f74a61499b117f7dd11aa30c4977612bbe6ae6299"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-6376"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6376""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-033_7e19e0ea0e05	MetaCyc:RXN-10995	BFO:0000050	MetaCyc:PWY-6376	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6376		"[{""reference_id"": ""MetaCyc:PWY-6376"", ""source_assertion"": ""The native full B pathway includes RXN-10995 and selects its L2R pathway layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-6376\""]/reaction-list; reaction-layout[Reaction/@frameid=\""RXN-10995\""]/direction""}]"	"[{""id"": ""MetaCyc:PWY-6376"", ""source_sha256"": ""dae85f1da639c7f6ea757c6f74a61499b117f7dd11aa30c4977612bbe6ae6299"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-6376"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6376""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-034_891aa19e1bbe	MetaCyc:RXN-10996	BFO:0000050	MetaCyc:PWY-6376	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6376		"[{""reference_id"": ""MetaCyc:PWY-6376"", ""source_assertion"": ""The native full B pathway includes RXN-10996 and selects its L2R pathway layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-6376\""]/reaction-list; reaction-layout[Reaction/@frameid=\""RXN-10996\""]/direction""}]"	"[{""id"": ""MetaCyc:PWY-6376"", ""source_sha256"": ""dae85f1da639c7f6ea757c6f74a61499b117f7dd11aa30c4977612bbe6ae6299"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-6376"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6376""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-035_77f433f52056	MetaCyc:RXN-10999	BFO:0000050	MetaCyc:PWY-6376	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6376		"[{""reference_id"": ""MetaCyc:PWY-6376"", ""source_assertion"": ""The native full B pathway includes RXN-10999 and selects its L2R pathway layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-6376\""]/reaction-list; reaction-layout[Reaction/@frameid=\""RXN-10999\""]/direction""}]"	"[{""id"": ""MetaCyc:PWY-6376"", ""source_sha256"": ""dae85f1da639c7f6ea757c6f74a61499b117f7dd11aa30c4977612bbe6ae6299"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-6376"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6376""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-036_23485eeef712	MetaCyc:RXN-11001	BFO:0000050	MetaCyc:PWY-6376	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6376	RXN-11001 retains the source-issued complete organic transformation. Primary-supported successive adenylations imply two ATP, two AMP, two diphosphate and two H+ with no net water in the selected ionic forms. Native MetaCyc and KEGG instead encode one ATP and water. This is an explicit curated coefficient correction, not exact native-equation equivalence or a measured ATP/product coupling ratio.	"[{""reference_id"": ""MetaCyc:PWY-6376"", ""source_assertion"": ""The native full B pathway includes RXN-11001 and selects its L2R pathway layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-6376\""]/reaction-list; reaction-layout[Reaction/@frameid=\""RXN-11001\""]/direction""}]"	"[{""id"": ""MetaCyc:PWY-6376"", ""source_sha256"": ""dae85f1da639c7f6ea757c6f74a61499b117f7dd11aa30c4977612bbe6ae6299"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native PWY-6376"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6376""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-037_d9f4d9ddc39d	MetaCyc:LYSDECARBOX-RXN	RO:0002413	MetaCyc:RXN-10995	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:LYSDECARBOX-RXN|MetaCyc:RXN-10995		"[{""reference_id"": ""MetaCyc:LYSDECARBOX-RXN"", ""source_assertion"": ""LYSDECARBOX-RXN produces native CADAVERINE, which supplies the connected transformation."", ""source_locator"": ""Reaction/right[Compound/@frameid=\""CADAVERINE\""]""}, {""reference_id"": ""MetaCyc:RXN-10995"", ""source_assertion"": ""RXN-10995 consumes the same native CADAVERINE."", ""source_locator"": ""Reaction/left[Compound/@frameid=\""CADAVERINE\""]; coefficient""}]"	"[{""id"": ""MetaCyc:LYSDECARBOX-RXN"", ""source_sha256"": ""f124e4cd7163352a336b9dd574b84eb6792385b4274eb88eed549e8f397a7b85"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native LYSDECARBOX-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:LYSDECARBOX-RXN""}, {""id"": ""MetaCyc:RXN-10995"", ""source_sha256"": ""755a35c3df4bd60be7b026bb92f95fc53473aa5c2baec77e1b9acb70060b71c2"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10995"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10995""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-038_51f8932be3d7	MetaCyc:RXN-10995	RO:0002413	MetaCyc:RXN-10996	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-10995|MetaCyc:RXN-10996		"[{""reference_id"": ""MetaCyc:RXN-10995"", ""source_assertion"": ""RXN-10995 produces native CPD-11953, which supplies the connected transformation."", ""source_locator"": ""Reaction/right[Compound/@frameid=\""CPD-11953\""]""}, {""reference_id"": ""MetaCyc:RXN-10996"", ""source_assertion"": ""RXN-10996 consumes the same native CPD-11953."", ""source_locator"": ""Reaction/left[Compound/@frameid=\""CPD-11953\""]; coefficient""}]"	"[{""id"": ""MetaCyc:RXN-10995"", ""source_sha256"": ""755a35c3df4bd60be7b026bb92f95fc53473aa5c2baec77e1b9acb70060b71c2"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10995"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10995""}, {""id"": ""MetaCyc:RXN-10996"", ""source_sha256"": ""d21cd0a6068731fca241a5729dbb74fc7e06faa504cc2b17f9d0a968c94dc6fa"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10996"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10996""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-039_7fb27c3e04fc	MetaCyc:RXN-10995	RO:0002413	MetaCyc:RXN-10999	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-10995|MetaCyc:RXN-10999		"[{""reference_id"": ""MetaCyc:RXN-10995"", ""source_assertion"": ""RXN-10995 produces native CPD-11953, which supplies the connected transformation."", ""source_locator"": ""Reaction/right[Compound/@frameid=\""CPD-11953\""]""}, {""reference_id"": ""MetaCyc:RXN-10999"", ""source_assertion"": ""RXN-10999 consumes the same native CPD-11953."", ""source_locator"": ""Reaction/left[Compound/@frameid=\""CPD-11953\""]; coefficient""}]"	"[{""id"": ""MetaCyc:RXN-10995"", ""source_sha256"": ""755a35c3df4bd60be7b026bb92f95fc53473aa5c2baec77e1b9acb70060b71c2"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10995"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10995""}, {""id"": ""MetaCyc:RXN-10999"", ""source_sha256"": ""c101e3b2d91dce9c0887c88c126048467e98d527635cebbedfef7777f7c66726"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10999"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10999""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-040_00e4c2482cd8	MetaCyc:RXN-10996	RO:0002413	MetaCyc:RXN-11001	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-10996|MetaCyc:RXN-11001	The upstream decarboxylation and hydroxylation operate three times, the succinyl branch twice and the acetyl branch once per B product.	"[{""reference_id"": ""MetaCyc:RXN-10996"", ""source_assertion"": ""RXN-10996 produces native CPD-11955, which supplies the connected transformation."", ""source_locator"": ""Reaction/right[Compound/@frameid=\""CPD-11955\""]""}, {""reference_id"": ""MetaCyc:RXN-11001"", ""source_assertion"": ""RXN-11001 consumes the same native CPD-11955; two HSC and one HAC are required per B product."", ""source_locator"": ""Reaction/left[Compound/@frameid=\""CPD-11955\""]; coefficient""}]"	"[{""id"": ""MetaCyc:RXN-10996"", ""source_sha256"": ""d21cd0a6068731fca241a5729dbb74fc7e06faa504cc2b17f9d0a968c94dc6fa"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10996"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10996""}, {""id"": ""MetaCyc:RXN-11001"", ""source_sha256"": ""3a4abb007c7bb06ec55603c9e732cb1eb6540f31f828c98bdf1b78cdb62216e9"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-11001"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11001""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-041_0ac363bb1573	MetaCyc:RXN-10999	RO:0002413	MetaCyc:RXN-11001	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-10999|MetaCyc:RXN-11001	The upstream decarboxylation and hydroxylation operate three times, the succinyl branch twice and the acetyl branch once per B product.	"[{""reference_id"": ""MetaCyc:RXN-10999"", ""source_assertion"": ""RXN-10999 produces native CPD-11959, which supplies the connected transformation."", ""source_locator"": ""Reaction/right[Compound/@frameid=\""CPD-11959\""]""}, {""reference_id"": ""MetaCyc:RXN-11001"", ""source_assertion"": ""RXN-11001 consumes the same native CPD-11959; two HSC and one HAC are required per B product."", ""source_locator"": ""Reaction/left[Compound/@frameid=\""CPD-11959\""]; coefficient""}]"	"[{""id"": ""MetaCyc:RXN-10999"", ""source_sha256"": ""c101e3b2d91dce9c0887c88c126048467e98d527635cebbedfef7777f7c66726"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-10999"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10999""}, {""id"": ""MetaCyc:RXN-11001"", ""source_sha256"": ""3a4abb007c7bb06ec55603c9e732cb1eb6540f31f828c98bdf1b78cdb62216e9"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native RXN-11001"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11001""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-042_583a500459f8	MetaCyc:SCO2785-MONOMER	BFO:0000050	MetaCyc:CPLX-7949	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7949	Two-subunit source stoichiometry; membership does not make each monomer an independent catalyst.	"[{""reference_id"": ""MetaCyc:CPLX-7949"", ""source_assertion"": ""The native physical DesD complex explicitly contains two copies of SCO2785-MONOMER."", ""source_locator"": ""Protein/component[Protein/@frameid=\""SCO2785-MONOMER\""]/coefficient""}]"	"[{""id"": ""MetaCyc:CPLX-7949"", ""source_sha256"": ""33718d8536034939f699d545bd125cb8301455a9ec34799fb828d31b17a99e2e"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CPLX-7949"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7949""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-043_a60c270d0fc5	MetaCyc:SCO2782-MONOMER	BFO:0000050	NCBITaxon:100226	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:SCO2782-MONOMER|UniProtKB:Q9L072		"[{""reference_id"": ""MetaCyc:SCO2782-MONOMER"", ""source_assertion"": ""The native protein species object identifies coelicolor A3(2), taxon100226, and its own gene locus."", ""source_locator"": ""Protein/species/Organism[@frameid=\""TAX-100226\""]; gene""}, {""reference_id"": ""UniProtKB:Q9L072"", ""source_assertion"": ""The current entry cross-identifies desA/SCO2782 and taxon100226; automatic activity annotations are separately adjudicated."", ""source_locator"": ""results[primaryAccession=\""Q9L072\""]/organism/taxonId; genes""}]"	"[{""id"": ""MetaCyc:SCO2782-MONOMER"", ""source_sha256"": ""6c1352618b665bc70876525504761b31c01cfc05f4d6491c5bf2f4a4185e3805"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native SCO2782-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:SCO2782-MONOMER""}, {""id"": ""UniProtKB:Q9L072"", ""source_sha256"": ""40f49d3bc21c6eb581891fae186b79c96851ed1a339c62bf418ebeba4c5f0905"", ""source_version"": ""UniProtKB 2026_03; complete original four-entry search batch retrieved 2026-10-11; unreviewed entries"", ""title"": ""UniProtKB Q9L072 complete current native entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28gene_exact%3AdesA+OR+gene_exact%3AdesB+OR+gene_exact%3AdesC+OR+gene_exact%3AdesD%29+AND+organism_id%3A100226&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-044_9811be6cde83	MetaCyc:SCO2783-MONOMER	BFO:0000050	NCBITaxon:100226	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:SCO2783-MONOMER|UniProtKB:Q9L071		"[{""reference_id"": ""MetaCyc:SCO2783-MONOMER"", ""source_assertion"": ""The native protein species object identifies coelicolor A3(2), taxon100226, and its own gene locus."", ""source_locator"": ""Protein/species/Organism[@frameid=\""TAX-100226\""]; gene""}, {""reference_id"": ""UniProtKB:Q9L071"", ""source_assertion"": ""The current entry cross-identifies desB/SCO2783 and taxon100226; automatic activity annotations are separately adjudicated."", ""source_locator"": ""results[primaryAccession=\""Q9L071\""]/organism/taxonId; genes""}]"	"[{""id"": ""MetaCyc:SCO2783-MONOMER"", ""source_sha256"": ""753135fe55cddbc1749e9dd9499cb24ea379bd91121f6dbf2d38a605698cffea"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native SCO2783-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:SCO2783-MONOMER""}, {""id"": ""UniProtKB:Q9L071"", ""source_sha256"": ""40f49d3bc21c6eb581891fae186b79c96851ed1a339c62bf418ebeba4c5f0905"", ""source_version"": ""UniProtKB 2026_03; complete original four-entry search batch retrieved 2026-10-11; unreviewed entries"", ""title"": ""UniProtKB Q9L071 complete current native entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28gene_exact%3AdesA+OR+gene_exact%3AdesB+OR+gene_exact%3AdesC+OR+gene_exact%3AdesD%29+AND+organism_id%3A100226&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-045_bc2e87ca59c4	MetaCyc:SCO2784-MONOMER	BFO:0000050	NCBITaxon:100226	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:SCO2784-MONOMER|UniProtKB:Q9L070		"[{""reference_id"": ""MetaCyc:SCO2784-MONOMER"", ""source_assertion"": ""The native protein species object identifies coelicolor A3(2), taxon100226, and its own gene locus."", ""source_locator"": ""Protein/species/Organism[@frameid=\""TAX-100226\""]; gene""}, {""reference_id"": ""UniProtKB:Q9L070"", ""source_assertion"": ""The current entry cross-identifies desC/SCO2784 and taxon100226; automatic activity annotations are separately adjudicated."", ""source_locator"": ""results[primaryAccession=\""Q9L070\""]/organism/taxonId; genes""}]"	"[{""id"": ""MetaCyc:SCO2784-MONOMER"", ""source_sha256"": ""9856a1077ca516a7cfc5c7037e69cb261688ad16306ccc268b39496b2e572879"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native SCO2784-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:SCO2784-MONOMER""}, {""id"": ""UniProtKB:Q9L070"", ""source_sha256"": ""40f49d3bc21c6eb581891fae186b79c96851ed1a339c62bf418ebeba4c5f0905"", ""source_version"": ""UniProtKB 2026_03; complete original four-entry search batch retrieved 2026-10-11; unreviewed entries"", ""title"": ""UniProtKB Q9L070 complete current native entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28gene_exact%3AdesA+OR+gene_exact%3AdesB+OR+gene_exact%3AdesC+OR+gene_exact%3AdesD%29+AND+organism_id%3A100226&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-046_7afdb08da4e3	MetaCyc:SCO2785-MONOMER	BFO:0000050	NCBITaxon:100226	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:SCO2785-MONOMER|UniProtKB:Q9L069		"[{""reference_id"": ""MetaCyc:SCO2785-MONOMER"", ""source_assertion"": ""The native protein species object identifies coelicolor A3(2), taxon100226, and its own gene locus."", ""source_locator"": ""Protein/species/Organism[@frameid=\""TAX-100226\""]; gene""}, {""reference_id"": ""UniProtKB:Q9L069"", ""source_assertion"": ""The current entry cross-identifies desD/SCO2785 and taxon100226; automatic activity annotations are separately adjudicated."", ""source_locator"": ""results[primaryAccession=\""Q9L069\""]/organism/taxonId; genes""}]"	"[{""id"": ""MetaCyc:SCO2785-MONOMER"", ""source_sha256"": ""ad17401f2ece0109f7a985dad3062cc9b1c6936eb337bd8d11ab630edd354df3"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native SCO2785-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:SCO2785-MONOMER""}, {""id"": ""UniProtKB:Q9L069"", ""source_sha256"": ""40f49d3bc21c6eb581891fae186b79c96851ed1a339c62bf418ebeba4c5f0905"", ""source_version"": ""UniProtKB 2026_03; complete original four-entry search batch retrieved 2026-10-11; unreviewed entries"", ""title"": ""UniProtKB Q9L069 complete current native entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28gene_exact%3AdesA+OR+gene_exact%3AdesB+OR+gene_exact%3AdesC+OR+gene_exact%3AdesD%29+AND+organism_id%3A100226&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-047_d90b815fc33b	MetaCyc:CPLX-7949	BFO:0000050	NCBITaxon:100226	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7949		"[{""reference_id"": ""MetaCyc:CPLX-7949"", ""source_assertion"": ""The native complex belongs to coelicolor A3(2), with an explicit taxon100226 cross-reference."", ""source_locator"": ""Protein/species/Organism/dblink[dblink-db=\""NCBI-TAXONOMY-DB\""]/dblink-oid""}]"	"[{""id"": ""MetaCyc:CPLX-7949"", ""source_sha256"": ""33718d8536034939f699d545bd125cb8301455a9ec34799fb828d31b17a99e2e"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native CPLX-7949"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7949""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-048_1c9c59520e2e	MetaCyc:PWY-6376	BFO:0000050	NCBITaxon:100226	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBITaxon:100226|PMID:29685972|PMID:37207292		"[{""reference_id"": ""PMID:29685972"", ""source_assertion"": ""The introduction identifies coelicolor A3(2) as producing B and E; experiments and supplement establish the M145 DesC precursor branches."", ""source_locator"": ""PMC5915712 Introduction §1; Results §2(a); Figure 3""}, {""reference_id"": ""PMID:37207292"", ""source_assertion"": ""ScDesD forms the B product from HSC-HSC and HAC in the purified-enzyme assay. The coelicolor implementation retains a proposed native DesB assignment."", ""source_locator"": ""Original manuscript Figure 3 p.11; coelicolor ortholog scope pp.2–3""}, {""reference_id"": ""NCBITaxon:100226"", ""source_assertion"": ""NCBI Taxonomy identifies the scoped organism as Streptomyces coelicolor A3(2)."", ""source_locator"": ""TaxaSet/Taxon/TaxId; ScientificName""}]"	"[{""id"": ""NCBITaxon:100226"", ""source_sha256"": ""e812291698a51a1a856e65b17390b9dc3cc02a2ab0a3aa0eea231dd04ebb287e"", ""source_version"": ""NCBI Taxonomy original XML retrieved 2026-10-11"", ""title"": ""NCBI Taxonomy Streptomyces coelicolor A3(2)"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=taxonomy&id=100226&retmode=xml""}, {""id"": ""PMID:29685972"", ""source_sha256"": ""1bd6c3e3a9a9048f03545ede3a17af2a8de138f070acc00827cec61ac5d557f3"", ""source_version"": ""Original full primary HTML retrieved 2026-10-11"", ""title"": ""Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC5915712/""}, {""id"": ""PMID:37207292"", ""source_sha256"": ""8f72641f62e460e677aa6d1a582c968ff93b89fcc24b487bb8dd2aa0ac1bfa9a"", ""source_version"": ""Original NSF-hosted author manuscript PDF; retrieved 2026-10-11"", ""title"": ""Siderophore Synthetase DesD Catalyzes N-to-C Condensation in Desferrioxamine Biosynthesis"", ""url"": ""https://par.nsf.gov/servlets/purl/10505308""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-049_1eb116fc331f	MetaCyc:SCO2782-MONOMER	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q9L072	Source-scoped automatic cofactor assignment; the complete original 2012 biochemical methods were not inspected.	"[{""reference_id"": ""UniProtKB:Q9L072"", ""source_assertion"": ""The current unreviewed DesA entry explicitly assigns pyridoxal phosphate (CHEBI:597326) by automatic annotation; this is not direct cofactor binding measured on the selected native protein."", ""source_locator"": ""results[primaryAccession=\""Q9L072\""]/comments[commentType=\""COFACTOR\""]/cofactors; evidences""}]"	"[{""id"": ""UniProtKB:Q9L072"", ""source_sha256"": ""40f49d3bc21c6eb581891fae186b79c96851ed1a339c62bf418ebeba4c5f0905"", ""source_version"": ""UniProtKB 2026_03; complete original four-entry search batch retrieved 2026-10-11; unreviewed entries"", ""title"": ""UniProtKB Q9L072 complete current native entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28gene_exact%3AdesA+OR+gene_exact%3AdesB+OR+gene_exact%3AdesC+OR+gene_exact%3AdesD%29+AND+organism_id%3A100226&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-6376_dfoB-edge-050_00624f086206	MetaCyc:SCO2783-MONOMER	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:SCO2783-MONOMER|UniProtKB:Q9L071	Explicitly inferred FAD cofactor assignment; direct FAD experiments concern S. sviceus. Bound flavin is not substituted for the generic exchanged redox classes.	"[{""reference_id"": ""UniProtKB:Q9L071"", ""source_assertion"": ""The current unreviewed entry separately assigns FAD (CHEBI:57692) as cofactor by ECO:0000256/ARBA00001974. This inferred binding assignment does not validate its conflicting MbtG substrate annotation or identify the physiological reductant."", ""source_locator"": ""results[primaryAccession=\""Q9L071\""]/comments[commentType=\""COFACTOR\""]/cofactors; evidences""}, {""reference_id"": ""MetaCyc:SCO2783-MONOMER"", ""source_assertion"": ""The native DesB comment identifies similarity to FAD-dependent amine monooxygenases but states that this coelicolor protein was not purified or biochemically characterized."", ""source_locator"": ""Protein/comment""}]"	"[{""id"": ""MetaCyc:SCO2783-MONOMER"", ""source_sha256"": ""753135fe55cddbc1749e9dd9499cb24ea379bd91121f6dbf2d38a605698cffea"", ""source_version"": ""MetaCyc 22.5 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc 22.5 native SCO2783-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:SCO2783-MONOMER""}, {""id"": ""UniProtKB:Q9L071"", ""source_sha256"": ""40f49d3bc21c6eb581891fae186b79c96851ed1a339c62bf418ebeba4c5f0905"", ""source_version"": ""UniProtKB 2026_03; complete original four-entry search batch retrieved 2026-10-11; unreviewed entries"", ""title"": ""UniProtKB Q9L071 complete current native entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28gene_exact%3AdesA+OR+gene_exact%3AdesB+OR+gene_exact%3AdesC+OR+gene_exact%3AdesD%29+AND+organism_id%3A100226&format=json&size=100""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-001_692dd377de26	KEGG:C00138	pathwaymech:consumes	KEGG:R01196	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:C00024|KEGG:C00138|KEGG:R01196	Stoichiometric coefficient 2; derived acid-base normalization of native KEGG R01196, with generic ferredoxin identity and unmeasured proton bookkeeping.	"[{""reference_id"": ""KEGG:R01196"", ""source_assertion"": ""Native R01196 defines reversible acetyl-CoA/CO2 reduction with two reduced-to-oxidized generic ferredoxins and two H+. The selected KEGG:C00138 substrates coefficient 2 uses an explicitly derived one-H+ normalization of its acid reference forms."", ""source_locator"": ""Original flatfile ENTRY R01196; NAME; DEFINITION; EQUATION; MODULE M00374""}, {""reference_id"": ""KEGG:C00024"", ""source_assertion"": ""The native batch gives acetyl-CoA C23H38N7O17P3S, CoA C21H36N7O16P3S and C00022 C3H4O3. Equal four-proton CoA shifts cancel; deprotonating product pyruvic acid releases one H+, reducing net input from two to one. This is derived bookkeeping."", ""source_locator"": ""Original five-entry batch ENTRY C00024/C00010/C00022; FORMULA; DBLINKS ChEBI""}, {""reference_id"": ""KEGG:C00138"", ""source_assertion"": ""The native Compound name denotes a generic ferredoxin redox state without a formula or a specific carrier accession or Fe-S cluster stoichiometry. It is not equated to a particular Rhea Fe-S protein class."", ""source_locator"": ""Original flatfile ENTRY; NAME; no FORMULA field""}]"	"[{""id"": ""KEGG:C00024"", ""source_sha256"": ""f535a194be2727c565e32e1ce24f6856ae497c068e20a4060005705d6248608f"", ""source_version"": ""Original five-entry batch retrieved 2026-10-11; digest covers entire batch"", ""title"": ""KEGG native small-molecule forms for R01196"", ""url"": ""https://rest.kegg.jp/get/C00024+C00011+C00022+C00010+C00080""}, {""id"": ""KEGG:C00138"", ""source_sha256"": ""9e21bfb263724c35cdffa7fe07687ea5ba9847fc0bca70290026ba86e352100a"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:45:41.128356+00:00; original response has no per-entry release designation"", ""title"": ""Reduced ferredoxin"", ""url"": ""https://rest.kegg.jp/get/C00138""}, {""id"": ""KEGG:R01196"", ""source_sha256"": ""d98a5c7a727196576fa268d700d196190e17f8218d257e9b74fcec1fd67e26b6"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:45:41.128609+00:00; original response has no per-entry release designation"", ""title"": ""pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)"", ""url"": ""https://rest.kegg.jp/get/R01196""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-002_2992895ae7ce	CHEBI:57288	pathwaymech:consumes	KEGG:R01196	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15361|KEGG:C00024|KEGG:R01196	Stoichiometric coefficient 1; derived acid-base normalization of native KEGG R01196, with generic ferredoxin identity and unmeasured proton bookkeeping.	"[{""reference_id"": ""KEGG:R01196"", ""source_assertion"": ""Native R01196 defines reversible acetyl-CoA/CO2 reduction with two reduced-to-oxidized generic ferredoxins and two H+. The selected CHEBI:57288 substrates coefficient 1 uses an explicitly derived one-H+ normalization of its acid reference forms."", ""source_locator"": ""Original flatfile ENTRY R01196; NAME; DEFINITION; EQUATION; MODULE M00374""}, {""reference_id"": ""KEGG:C00024"", ""source_assertion"": ""The native batch gives acetyl-CoA C23H38N7O17P3S, CoA C21H36N7O16P3S and C00022 C3H4O3. Equal four-proton CoA shifts cancel; deprotonating product pyruvic acid releases one H+, reducing net input from two to one. This is derived bookkeeping."", ""source_locator"": ""Original five-entry batch ENTRY C00024/C00010/C00022; FORMULA; DBLINKS ChEBI""}, {""reference_id"": ""CHEBI:15361"", ""source_assertion"": ""ChEBI defines pyruvate as the conjugate base of pyruvic acid. The selected CoA and acetyl-CoA tetraanions each lose four H relative to the KEGG acid formulas; this does not change their carbon skeletons."", ""source_locator"": ""ChEBI255 CHEBI:15361 IAO:0000115/formula; CHEBI:57287 and CHEBI:57288 definitions/formulas; acid forms CHEBI:32816/15346/15351""}]"	"[{""id"": ""CHEBI:15361"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original uncompressed semantic SQL database, queried at the exact subjects in the source locator"", ""title"": ""pyruvate"", ""url"": ""https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15361""}, {""id"": ""KEGG:C00024"", ""source_sha256"": ""f535a194be2727c565e32e1ce24f6856ae497c068e20a4060005705d6248608f"", ""source_version"": ""Original five-entry batch retrieved 2026-10-11; digest covers entire batch"", ""title"": ""KEGG native small-molecule forms for R01196"", ""url"": ""https://rest.kegg.jp/get/C00024+C00011+C00022+C00010+C00080""}, {""id"": ""KEGG:R01196"", ""source_sha256"": ""d98a5c7a727196576fa268d700d196190e17f8218d257e9b74fcec1fd67e26b6"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:45:41.128609+00:00; original response has no per-entry release designation"", ""title"": ""pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)"", ""url"": ""https://rest.kegg.jp/get/R01196""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-003_bcec41266e42	CHEBI:16526	pathwaymech:consumes	KEGG:R01196	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:C00024|KEGG:R01196	Stoichiometric coefficient 1; derived acid-base normalization of native KEGG R01196, with generic ferredoxin identity and unmeasured proton bookkeeping.	"[{""reference_id"": ""KEGG:R01196"", ""source_assertion"": ""Native R01196 defines reversible acetyl-CoA/CO2 reduction with two reduced-to-oxidized generic ferredoxins and two H+. The selected CHEBI:16526 substrates coefficient 1 uses an explicitly derived one-H+ normalization of its acid reference forms."", ""source_locator"": ""Original flatfile ENTRY R01196; NAME; DEFINITION; EQUATION; MODULE M00374""}, {""reference_id"": ""KEGG:C00024"", ""source_assertion"": ""The native batch gives acetyl-CoA C23H38N7O17P3S, CoA C21H36N7O16P3S and C00022 C3H4O3. Equal four-proton CoA shifts cancel; deprotonating product pyruvic acid releases one H+, reducing net input from two to one. This is derived bookkeeping."", ""source_locator"": ""Original five-entry batch ENTRY C00024/C00010/C00022; FORMULA; DBLINKS ChEBI""}]"	"[{""id"": ""KEGG:C00024"", ""source_sha256"": ""f535a194be2727c565e32e1ce24f6856ae497c068e20a4060005705d6248608f"", ""source_version"": ""Original five-entry batch retrieved 2026-10-11; digest covers entire batch"", ""title"": ""KEGG native small-molecule forms for R01196"", ""url"": ""https://rest.kegg.jp/get/C00024+C00011+C00022+C00010+C00080""}, {""id"": ""KEGG:R01196"", ""source_sha256"": ""d98a5c7a727196576fa268d700d196190e17f8218d257e9b74fcec1fd67e26b6"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:45:41.128609+00:00; original response has no per-entry release designation"", ""title"": ""pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)"", ""url"": ""https://rest.kegg.jp/get/R01196""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-004_3e3cf0399dbe	CHEBI:15378	pathwaymech:consumes	KEGG:R01196	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15361|KEGG:C00024|KEGG:R01196	Stoichiometric coefficient 1; derived acid-base normalization of native KEGG R01196, with generic ferredoxin identity and unmeasured proton bookkeeping.	"[{""reference_id"": ""KEGG:R01196"", ""source_assertion"": ""Native R01196 defines reversible acetyl-CoA/CO2 reduction with two reduced-to-oxidized generic ferredoxins and two H+. The selected CHEBI:15378 substrates coefficient 1 uses an explicitly derived one-H+ normalization of its acid reference forms."", ""source_locator"": ""Original flatfile ENTRY R01196; NAME; DEFINITION; EQUATION; MODULE M00374""}, {""reference_id"": ""KEGG:C00024"", ""source_assertion"": ""The native batch gives acetyl-CoA C23H38N7O17P3S, CoA C21H36N7O16P3S and C00022 C3H4O3. Equal four-proton CoA shifts cancel; deprotonating product pyruvic acid releases one H+, reducing net input from two to one. This is derived bookkeeping."", ""source_locator"": ""Original five-entry batch ENTRY C00024/C00010/C00022; FORMULA; DBLINKS ChEBI""}, {""reference_id"": ""CHEBI:15361"", ""source_assertion"": ""ChEBI defines pyruvate as the conjugate base of pyruvic acid. The selected CoA and acetyl-CoA tetraanions each lose four H relative to the KEGG acid formulas; this does not change their carbon skeletons."", ""source_locator"": ""ChEBI255 CHEBI:15361 IAO:0000115/formula; CHEBI:57287 and CHEBI:57288 definitions/formulas; acid forms CHEBI:32816/15346/15351""}]"	"[{""id"": ""CHEBI:15361"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original uncompressed semantic SQL database, queried at the exact subjects in the source locator"", ""title"": ""pyruvate"", ""url"": ""https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15361""}, {""id"": ""KEGG:C00024"", ""source_sha256"": ""f535a194be2727c565e32e1ce24f6856ae497c068e20a4060005705d6248608f"", ""source_version"": ""Original five-entry batch retrieved 2026-10-11; digest covers entire batch"", ""title"": ""KEGG native small-molecule forms for R01196"", ""url"": ""https://rest.kegg.jp/get/C00024+C00011+C00022+C00010+C00080""}, {""id"": ""KEGG:R01196"", ""source_sha256"": ""d98a5c7a727196576fa268d700d196190e17f8218d257e9b74fcec1fd67e26b6"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:45:41.128609+00:00; original response has no per-entry release designation"", ""title"": ""pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)"", ""url"": ""https://rest.kegg.jp/get/R01196""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-005_ad488b64bab1	KEGG:R01196	pathwaymech:produces	KEGG:C00139	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:C00024|KEGG:C00139|KEGG:R01196	Stoichiometric coefficient 2; derived acid-base normalization of native KEGG R01196, with generic ferredoxin identity and unmeasured proton bookkeeping.	"[{""reference_id"": ""KEGG:R01196"", ""source_assertion"": ""Native R01196 defines reversible acetyl-CoA/CO2 reduction with two reduced-to-oxidized generic ferredoxins and two H+. The selected KEGG:C00139 products coefficient 2 uses an explicitly derived one-H+ normalization of its acid reference forms."", ""source_locator"": ""Original flatfile ENTRY R01196; NAME; DEFINITION; EQUATION; MODULE M00374""}, {""reference_id"": ""KEGG:C00024"", ""source_assertion"": ""The native batch gives acetyl-CoA C23H38N7O17P3S, CoA C21H36N7O16P3S and C00022 C3H4O3. Equal four-proton CoA shifts cancel; deprotonating product pyruvic acid releases one H+, reducing net input from two to one. This is derived bookkeeping."", ""source_locator"": ""Original five-entry batch ENTRY C00024/C00010/C00022; FORMULA; DBLINKS ChEBI""}, {""reference_id"": ""KEGG:C00139"", ""source_assertion"": ""The native Compound name denotes a generic ferredoxin redox state without a formula or a specific carrier accession or Fe-S cluster stoichiometry. It is not equated to a particular Rhea Fe-S protein class."", ""source_locator"": ""Original flatfile ENTRY; NAME; no FORMULA field""}]"	"[{""id"": ""KEGG:C00024"", ""source_sha256"": ""f535a194be2727c565e32e1ce24f6856ae497c068e20a4060005705d6248608f"", ""source_version"": ""Original five-entry batch retrieved 2026-10-11; digest covers entire batch"", ""title"": ""KEGG native small-molecule forms for R01196"", ""url"": ""https://rest.kegg.jp/get/C00024+C00011+C00022+C00010+C00080""}, {""id"": ""KEGG:C00139"", ""source_sha256"": ""8464d150fa17d838544e9ae8182a1b1937fd6748d72aa4bcda44c4ba9a1f3739"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:45:41.128565+00:00; original response has no per-entry release designation"", ""title"": ""Oxidized ferredoxin"", ""url"": ""https://rest.kegg.jp/get/C00139""}, {""id"": ""KEGG:R01196"", ""source_sha256"": ""d98a5c7a727196576fa268d700d196190e17f8218d257e9b74fcec1fd67e26b6"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:45:41.128609+00:00; original response has no per-entry release designation"", ""title"": ""pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)"", ""url"": ""https://rest.kegg.jp/get/R01196""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-006_a234afb45545	KEGG:R01196	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15361|KEGG:C00024|KEGG:R01196	Stoichiometric coefficient 1; derived acid-base normalization of native KEGG R01196, with generic ferredoxin identity and unmeasured proton bookkeeping.	"[{""reference_id"": ""KEGG:R01196"", ""source_assertion"": ""Native R01196 defines reversible acetyl-CoA/CO2 reduction with two reduced-to-oxidized generic ferredoxins and two H+. The selected CHEBI:15361 products coefficient 1 uses an explicitly derived one-H+ normalization of its acid reference forms."", ""source_locator"": ""Original flatfile ENTRY R01196; NAME; DEFINITION; EQUATION; MODULE M00374""}, {""reference_id"": ""KEGG:C00024"", ""source_assertion"": ""The native batch gives acetyl-CoA C23H38N7O17P3S, CoA C21H36N7O16P3S and C00022 C3H4O3. Equal four-proton CoA shifts cancel; deprotonating product pyruvic acid releases one H+, reducing net input from two to one. This is derived bookkeeping."", ""source_locator"": ""Original five-entry batch ENTRY C00024/C00010/C00022; FORMULA; DBLINKS ChEBI""}, {""reference_id"": ""CHEBI:15361"", ""source_assertion"": ""ChEBI defines pyruvate as the conjugate base of pyruvic acid. The selected CoA and acetyl-CoA tetraanions each lose four H relative to the KEGG acid formulas; this does not change their carbon skeletons."", ""source_locator"": ""ChEBI255 CHEBI:15361 IAO:0000115/formula; CHEBI:57287 and CHEBI:57288 definitions/formulas; acid forms CHEBI:32816/15346/15351""}]"	"[{""id"": ""CHEBI:15361"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original uncompressed semantic SQL database, queried at the exact subjects in the source locator"", ""title"": ""pyruvate"", ""url"": ""https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15361""}, {""id"": ""KEGG:C00024"", ""source_sha256"": ""f535a194be2727c565e32e1ce24f6856ae497c068e20a4060005705d6248608f"", ""source_version"": ""Original five-entry batch retrieved 2026-10-11; digest covers entire batch"", ""title"": ""KEGG native small-molecule forms for R01196"", ""url"": ""https://rest.kegg.jp/get/C00024+C00011+C00022+C00010+C00080""}, {""id"": ""KEGG:R01196"", ""source_sha256"": ""d98a5c7a727196576fa268d700d196190e17f8218d257e9b74fcec1fd67e26b6"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:45:41.128609+00:00; original response has no per-entry release designation"", ""title"": ""pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)"", ""url"": ""https://rest.kegg.jp/get/R01196""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-007_360398b00ab5	KEGG:R01196	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15361|KEGG:C00024|KEGG:R01196	Stoichiometric coefficient 1; derived acid-base normalization of native KEGG R01196, with generic ferredoxin identity and unmeasured proton bookkeeping.	"[{""reference_id"": ""KEGG:R01196"", ""source_assertion"": ""Native R01196 defines reversible acetyl-CoA/CO2 reduction with two reduced-to-oxidized generic ferredoxins and two H+. The selected CHEBI:57287 products coefficient 1 uses an explicitly derived one-H+ normalization of its acid reference forms."", ""source_locator"": ""Original flatfile ENTRY R01196; NAME; DEFINITION; EQUATION; MODULE M00374""}, {""reference_id"": ""KEGG:C00024"", ""source_assertion"": ""The native batch gives acetyl-CoA C23H38N7O17P3S, CoA C21H36N7O16P3S and C00022 C3H4O3. Equal four-proton CoA shifts cancel; deprotonating product pyruvic acid releases one H+, reducing net input from two to one. This is derived bookkeeping."", ""source_locator"": ""Original five-entry batch ENTRY C00024/C00010/C00022; FORMULA; DBLINKS ChEBI""}, {""reference_id"": ""CHEBI:15361"", ""source_assertion"": ""ChEBI defines pyruvate as the conjugate base of pyruvic acid. The selected CoA and acetyl-CoA tetraanions each lose four H relative to the KEGG acid formulas; this does not change their carbon skeletons."", ""source_locator"": ""ChEBI255 CHEBI:15361 IAO:0000115/formula; CHEBI:57287 and CHEBI:57288 definitions/formulas; acid forms CHEBI:32816/15346/15351""}]"	"[{""id"": ""CHEBI:15361"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original uncompressed semantic SQL database, queried at the exact subjects in the source locator"", ""title"": ""pyruvate"", ""url"": ""https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15361""}, {""id"": ""KEGG:C00024"", ""source_sha256"": ""f535a194be2727c565e32e1ce24f6856ae497c068e20a4060005705d6248608f"", ""source_version"": ""Original five-entry batch retrieved 2026-10-11; digest covers entire batch"", ""title"": ""KEGG native small-molecule forms for R01196"", ""url"": ""https://rest.kegg.jp/get/C00024+C00011+C00022+C00010+C00080""}, {""id"": ""KEGG:R01196"", ""source_sha256"": ""d98a5c7a727196576fa268d700d196190e17f8218d257e9b74fcec1fd67e26b6"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:45:41.128609+00:00; original response has no per-entry release designation"", ""title"": ""pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)"", ""url"": ""https://rest.kegg.jp/get/R01196""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-008_ebc421b3dc14	CHEBI:15361	pathwaymech:consumes	RHEA:11365	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11365	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:11365"", ""source_assertion"": ""Rhea directed reaction 11365 places CHEBI:15361 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/11365> rh:substrates <http://rdf.rhea-db.org/11364_L>; <http://rdf.rhea-db.org/11364_L> rh:contains1 <http://rdf.rhea-db.org/Participant_11364_compound_3719>; <http://rdf.rhea-db.org/Participant_11364_compound_3719> rh:compound <http://rdf.rhea-db.org/Compound_3719>; compound rh:accession""}]"	"[{""id"": ""RHEA:11365"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""pyruvate + ATP + H2O => phosphoenolpyruvate + AMP + phosphate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/11365""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-009_0fad0c8f10bc	CHEBI:30616	pathwaymech:consumes	RHEA:11365	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11365	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:11365"", ""source_assertion"": ""Rhea directed reaction 11365 places CHEBI:30616 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/11365> rh:substrates <http://rdf.rhea-db.org/11364_L>; <http://rdf.rhea-db.org/11364_L> rh:contains1 <http://rdf.rhea-db.org/Participant_11364_compound_6372>; <http://rdf.rhea-db.org/Participant_11364_compound_6372> rh:compound <http://rdf.rhea-db.org/Compound_6372>; compound rh:accession""}]"	"[{""id"": ""RHEA:11365"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""pyruvate + ATP + H2O => phosphoenolpyruvate + AMP + phosphate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/11365""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-010_c68ac0aaf86a	CHEBI:15377	pathwaymech:consumes	RHEA:11365	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11365	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:11365"", ""source_assertion"": ""Rhea directed reaction 11365 places CHEBI:15377 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/11365> rh:substrates <http://rdf.rhea-db.org/11364_L>; <http://rdf.rhea-db.org/11364_L> rh:contains1 <http://rdf.rhea-db.org/Participant_11364_compound_1283>; <http://rdf.rhea-db.org/Participant_11364_compound_1283> rh:compound <http://rdf.rhea-db.org/Compound_1283>; compound rh:accession""}]"	"[{""id"": ""RHEA:11365"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""pyruvate + ATP + H2O => phosphoenolpyruvate + AMP + phosphate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/11365""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-011_6912b5f38596	RHEA:11365	pathwaymech:produces	CHEBI:58702	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11365	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:11365"", ""source_assertion"": ""Rhea directed reaction 11365 places CHEBI:58702 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/11365> rh:products <http://rdf.rhea-db.org/11364_R>; <http://rdf.rhea-db.org/11364_R> rh:contains1 <http://rdf.rhea-db.org/Participant_11364_compound_3582>; <http://rdf.rhea-db.org/Participant_11364_compound_3582> rh:compound <http://rdf.rhea-db.org/Compound_3582>; compound rh:accession""}]"	"[{""id"": ""RHEA:11365"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""pyruvate + ATP + H2O => phosphoenolpyruvate + AMP + phosphate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/11365""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-012_d63d0349304b	RHEA:11365	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11365	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:11365"", ""source_assertion"": ""Rhea directed reaction 11365 places CHEBI:456215 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/11365> rh:products <http://rdf.rhea-db.org/11364_R>; <http://rdf.rhea-db.org/11364_R> rh:contains1 <http://rdf.rhea-db.org/Participant_11364_compound_2590>; <http://rdf.rhea-db.org/Participant_11364_compound_2590> rh:compound <http://rdf.rhea-db.org/Compound_2590>; compound rh:accession""}]"	"[{""id"": ""RHEA:11365"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""pyruvate + ATP + H2O => phosphoenolpyruvate + AMP + phosphate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/11365""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-013_10efb706a6f1	RHEA:11365	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11365	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:11365"", ""source_assertion"": ""Rhea directed reaction 11365 places CHEBI:43474 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/11365> rh:products <http://rdf.rhea-db.org/11364_R>; <http://rdf.rhea-db.org/11364_R> rh:contains1 <http://rdf.rhea-db.org/Participant_11364_compound_5518>; <http://rdf.rhea-db.org/Participant_11364_compound_5518> rh:compound <http://rdf.rhea-db.org/Compound_5518>; compound rh:accession""}]"	"[{""id"": ""RHEA:11365"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""pyruvate + ATP + H2O => phosphoenolpyruvate + AMP + phosphate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/11365""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-014_7dd2b7948c68	RHEA:11365	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11365	Stoichiometric coefficient 2.	"[{""reference_id"": ""RHEA:11365"", ""source_assertion"": ""Rhea directed reaction 11365 places CHEBI:15378 on its products side with coefficient 2."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/11365> rh:products <http://rdf.rhea-db.org/11364_R>; <http://rdf.rhea-db.org/11364_R> rh:contains2 <http://rdf.rhea-db.org/Participant_11364_compound_3249>; <http://rdf.rhea-db.org/Participant_11364_compound_3249> rh:compound <http://rdf.rhea-db.org/Compound_3249>; compound rh:accession""}]"	"[{""id"": ""RHEA:11365"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""pyruvate + ATP + H2O => phosphoenolpyruvate + AMP + phosphate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/11365""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-015_a8c19b56643f	CHEBI:58702	pathwaymech:consumes	RHEA:28372	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28372	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:28372"", ""source_assertion"": ""Rhea directed reaction 28372 places CHEBI:58702 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/28372> rh:substrates <http://rdf.rhea-db.org/28370_R>; <http://rdf.rhea-db.org/28370_R> rh:contains1 <http://rdf.rhea-db.org/Participant_28370_compound_3582>; <http://rdf.rhea-db.org/Participant_28370_compound_3582> rh:compound <http://rdf.rhea-db.org/Compound_3582>; compound rh:accession""}]"	"[{""id"": ""RHEA:28372"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""phosphoenolpyruvate + hydrogencarbonate => oxaloacetate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/28372""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-016_2e0be2f042ba	CHEBI:17544	pathwaymech:consumes	RHEA:28372	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28372	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:28372"", ""source_assertion"": ""Rhea directed reaction 28372 places CHEBI:17544 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/28372> rh:substrates <http://rdf.rhea-db.org/28370_R>; <http://rdf.rhea-db.org/28370_R> rh:contains1 <http://rdf.rhea-db.org/Participant_28370_compound_1123>; <http://rdf.rhea-db.org/Participant_28370_compound_1123> rh:compound <http://rdf.rhea-db.org/Compound_1123>; compound rh:accession""}]"	"[{""id"": ""RHEA:28372"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""phosphoenolpyruvate + hydrogencarbonate => oxaloacetate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/28372""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-017_d79f056bc0d4	RHEA:28372	pathwaymech:produces	CHEBI:16452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28372	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:28372"", ""source_assertion"": ""Rhea directed reaction 28372 places CHEBI:16452 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/28372> rh:products <http://rdf.rhea-db.org/28370_L>; <http://rdf.rhea-db.org/28370_L> rh:contains1 <http://rdf.rhea-db.org/Participant_28370_compound_5219>; <http://rdf.rhea-db.org/Participant_28370_compound_5219> rh:compound <http://rdf.rhea-db.org/Compound_5219>; compound rh:accession""}]"	"[{""id"": ""RHEA:28372"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""phosphoenolpyruvate + hydrogencarbonate => oxaloacetate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/28372""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-018_3b59fdbfb444	RHEA:28372	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28372	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:28372"", ""source_assertion"": ""Rhea directed reaction 28372 places CHEBI:43474 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/28372> rh:products <http://rdf.rhea-db.org/28370_L>; <http://rdf.rhea-db.org/28370_L> rh:contains1 <http://rdf.rhea-db.org/Participant_28370_compound_5518>; <http://rdf.rhea-db.org/Participant_28370_compound_5518> rh:compound <http://rdf.rhea-db.org/Compound_5518>; compound rh:accession""}]"	"[{""id"": ""RHEA:28372"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""phosphoenolpyruvate + hydrogencarbonate => oxaloacetate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/28372""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-019_8dab36cdd596	CHEBI:16452	pathwaymech:consumes	RHEA:21434	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21434	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:21434"", ""source_assertion"": ""Rhea directed reaction 21434 places CHEBI:16452 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/21434> rh:substrates <http://rdf.rhea-db.org/21432_R>; <http://rdf.rhea-db.org/21432_R> rh:contains1 <http://rdf.rhea-db.org/Participant_21432_compound_5219>; <http://rdf.rhea-db.org/Participant_21432_compound_5219> rh:compound <http://rdf.rhea-db.org/Compound_5219>; compound rh:accession""}]"	"[{""id"": ""RHEA:21434"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""oxaloacetate + NADH + H(+) => (S)-malate + NAD(+)"", ""url"": ""https://www.rhea-db.org/rhea/21434""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-020_768a058b0973	CHEBI:57945	pathwaymech:consumes	RHEA:21434	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21434	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:21434"", ""source_assertion"": ""Rhea directed reaction 21434 places CHEBI:57945 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/21434> rh:substrates <http://rdf.rhea-db.org/21432_R>; <http://rdf.rhea-db.org/21432_R> rh:contains1 <http://rdf.rhea-db.org/Participant_21432_compound_1650>; <http://rdf.rhea-db.org/Participant_21432_compound_1650> rh:compound <http://rdf.rhea-db.org/Compound_1650>; compound rh:accession""}]"	"[{""id"": ""RHEA:21434"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""oxaloacetate + NADH + H(+) => (S)-malate + NAD(+)"", ""url"": ""https://www.rhea-db.org/rhea/21434""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-021_3a7fb1036119	CHEBI:15378	pathwaymech:consumes	RHEA:21434	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21434	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:21434"", ""source_assertion"": ""Rhea directed reaction 21434 places CHEBI:15378 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/21434> rh:substrates <http://rdf.rhea-db.org/21432_R>; <http://rdf.rhea-db.org/21432_R> rh:contains1 <http://rdf.rhea-db.org/Participant_21432_compound_3249>; <http://rdf.rhea-db.org/Participant_21432_compound_3249> rh:compound <http://rdf.rhea-db.org/Compound_3249>; compound rh:accession""}]"	"[{""id"": ""RHEA:21434"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""oxaloacetate + NADH + H(+) => (S)-malate + NAD(+)"", ""url"": ""https://www.rhea-db.org/rhea/21434""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-022_d075a95df0d4	RHEA:21434	pathwaymech:produces	CHEBI:15589	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21434	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:21434"", ""source_assertion"": ""Rhea directed reaction 21434 places CHEBI:15589 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/21434> rh:products <http://rdf.rhea-db.org/21432_L>; <http://rdf.rhea-db.org/21432_L> rh:contains1 <http://rdf.rhea-db.org/Participant_21432_compound_3953>; <http://rdf.rhea-db.org/Participant_21432_compound_3953> rh:compound <http://rdf.rhea-db.org/Compound_3953>; compound rh:accession""}]"	"[{""id"": ""RHEA:21434"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""oxaloacetate + NADH + H(+) => (S)-malate + NAD(+)"", ""url"": ""https://www.rhea-db.org/rhea/21434""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-023_a499b225bf6a	RHEA:21434	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21434	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:21434"", ""source_assertion"": ""Rhea directed reaction 21434 places CHEBI:57540 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/21434> rh:products <http://rdf.rhea-db.org/21432_L>; <http://rdf.rhea-db.org/21432_L> rh:contains1 <http://rdf.rhea-db.org/Participant_21432_compound_3484>; <http://rdf.rhea-db.org/Participant_21432_compound_3484> rh:compound <http://rdf.rhea-db.org/Compound_3484>; compound rh:accession""}]"	"[{""id"": ""RHEA:21434"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""oxaloacetate + NADH + H(+) => (S)-malate + NAD(+)"", ""url"": ""https://www.rhea-db.org/rhea/21434""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-024_309d59a592a5	CHEBI:15589	pathwaymech:consumes	RHEA:12461	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12461	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:12461"", ""source_assertion"": ""Rhea directed reaction 12461 places CHEBI:15589 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/12461> rh:substrates <http://rdf.rhea-db.org/12460_L>; <http://rdf.rhea-db.org/12460_L> rh:contains1 <http://rdf.rhea-db.org/Participant_12460_compound_3953>; <http://rdf.rhea-db.org/Participant_12460_compound_3953> rh:compound <http://rdf.rhea-db.org/Compound_3953>; compound rh:accession""}]"	"[{""id"": ""RHEA:12461"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(S)-malate => fumarate + H2O"", ""url"": ""https://www.rhea-db.org/rhea/12461""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-025_492366b26f33	RHEA:12461	pathwaymech:produces	CHEBI:29806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12461	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:12461"", ""source_assertion"": ""Rhea directed reaction 12461 places CHEBI:29806 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/12461> rh:products <http://rdf.rhea-db.org/12460_R>; <http://rdf.rhea-db.org/12460_R> rh:contains1 <http://rdf.rhea-db.org/Participant_12460_compound_3031>; <http://rdf.rhea-db.org/Participant_12460_compound_3031> rh:compound <http://rdf.rhea-db.org/Compound_3031>; compound rh:accession""}]"	"[{""id"": ""RHEA:12461"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(S)-malate => fumarate + H2O"", ""url"": ""https://www.rhea-db.org/rhea/12461""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-026_e4cba26b510f	RHEA:12461	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12461	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:12461"", ""source_assertion"": ""Rhea directed reaction 12461 places CHEBI:15377 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/12461> rh:products <http://rdf.rhea-db.org/12460_R>; <http://rdf.rhea-db.org/12460_R> rh:contains1 <http://rdf.rhea-db.org/Participant_12460_compound_1283>; <http://rdf.rhea-db.org/Participant_12460_compound_1283> rh:compound <http://rdf.rhea-db.org/Compound_1283>; compound rh:accession""}]"	"[{""id"": ""RHEA:12461"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(S)-malate => fumarate + H2O"", ""url"": ""https://www.rhea-db.org/rhea/12461""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-027_56571ffe3006	CHEBI:29806	pathwaymech:consumes	RHEA:16359	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16359	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:16359"", ""source_assertion"": ""Rhea directed reaction 16359 places CHEBI:29806 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/16359> rh:substrates <http://rdf.rhea-db.org/16357_R>; <http://rdf.rhea-db.org/16357_R> rh:contains1 <http://rdf.rhea-db.org/Participant_16357_compound_3031>; <http://rdf.rhea-db.org/Participant_16357_compound_3031> rh:compound <http://rdf.rhea-db.org/Compound_3031>; compound rh:accession""}]"	"[{""id"": ""RHEA:16359"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""fumarate + AH2 => succinate + A"", ""url"": ""https://www.rhea-db.org/rhea/16359""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-028_fa15abb913fa	CHEBI:17499	pathwaymech:consumes	RHEA:16359	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16359	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:16359"", ""source_assertion"": ""Rhea directed reaction 16359 places CHEBI:17499 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/16359> rh:substrates <http://rdf.rhea-db.org/16357_R>; <http://rdf.rhea-db.org/16357_R> rh:contains1 <http://rdf.rhea-db.org/Participant_16357_compound_1304>; <http://rdf.rhea-db.org/Participant_16357_compound_1304> rh:compound <http://rdf.rhea-db.org/Compound_1304>; compound rh:accession""}]"	"[{""id"": ""RHEA:16359"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""fumarate + AH2 => succinate + A"", ""url"": ""https://www.rhea-db.org/rhea/16359""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-029_1386b52be479	RHEA:16359	pathwaymech:produces	CHEBI:30031	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16359	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:16359"", ""source_assertion"": ""Rhea directed reaction 16359 places CHEBI:30031 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/16359> rh:products <http://rdf.rhea-db.org/16357_L>; <http://rdf.rhea-db.org/16357_L> rh:contains1 <http://rdf.rhea-db.org/Participant_16357_compound_2501>; <http://rdf.rhea-db.org/Participant_16357_compound_2501> rh:compound <http://rdf.rhea-db.org/Compound_2501>; compound rh:accession""}]"	"[{""id"": ""RHEA:16359"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""fumarate + AH2 => succinate + A"", ""url"": ""https://www.rhea-db.org/rhea/16359""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-030_5db403ae1dce	RHEA:16359	pathwaymech:produces	CHEBI:13193	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16359	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:16359"", ""source_assertion"": ""Rhea directed reaction 16359 places CHEBI:13193 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/16359> rh:products <http://rdf.rhea-db.org/16357_L>; <http://rdf.rhea-db.org/16357_L> rh:contains1 <http://rdf.rhea-db.org/Participant_16357_compound_3512>; <http://rdf.rhea-db.org/Participant_16357_compound_3512> rh:compound <http://rdf.rhea-db.org/Compound_3512>; compound rh:accession""}]"	"[{""id"": ""RHEA:16359"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""fumarate + AH2 => succinate + A"", ""url"": ""https://www.rhea-db.org/rhea/16359""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-031_8acc5c7163c6	CHEBI:30031	pathwaymech:consumes	RHEA:17662	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17662	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:17662"", ""source_assertion"": ""Rhea directed reaction 17662 places CHEBI:30031 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/17662> rh:substrates <http://rdf.rhea-db.org/17661_L>; <http://rdf.rhea-db.org/17661_L> rh:contains1 <http://rdf.rhea-db.org/Participant_17661_compound_2501>; <http://rdf.rhea-db.org/Participant_17661_compound_2501> rh:compound <http://rdf.rhea-db.org/Compound_2501>; compound rh:accession""}]"	"[{""id"": ""RHEA:17662"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinate + ATP + CoA => succinyl-CoA + ADP + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/17662""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-032_25a83940a599	CHEBI:30616	pathwaymech:consumes	RHEA:17662	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17662	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:17662"", ""source_assertion"": ""Rhea directed reaction 17662 places CHEBI:30616 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/17662> rh:substrates <http://rdf.rhea-db.org/17661_L>; <http://rdf.rhea-db.org/17661_L> rh:contains1 <http://rdf.rhea-db.org/Participant_17661_compound_6372>; <http://rdf.rhea-db.org/Participant_17661_compound_6372> rh:compound <http://rdf.rhea-db.org/Compound_6372>; compound rh:accession""}]"	"[{""id"": ""RHEA:17662"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinate + ATP + CoA => succinyl-CoA + ADP + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/17662""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-033_7cc0c1d22085	CHEBI:57287	pathwaymech:consumes	RHEA:17662	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17662	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:17662"", ""source_assertion"": ""Rhea directed reaction 17662 places CHEBI:57287 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/17662> rh:substrates <http://rdf.rhea-db.org/17661_L>; <http://rdf.rhea-db.org/17661_L> rh:contains1 <http://rdf.rhea-db.org/Participant_17661_compound_1264>; <http://rdf.rhea-db.org/Participant_17661_compound_1264> rh:compound <http://rdf.rhea-db.org/Compound_1264>; compound rh:accession""}]"	"[{""id"": ""RHEA:17662"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinate + ATP + CoA => succinyl-CoA + ADP + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/17662""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-034_34416253e5c7	RHEA:17662	pathwaymech:produces	CHEBI:57292	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17662	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:17662"", ""source_assertion"": ""Rhea directed reaction 17662 places CHEBI:57292 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/17662> rh:products <http://rdf.rhea-db.org/17661_R>; <http://rdf.rhea-db.org/17661_R> rh:contains1 <http://rdf.rhea-db.org/Participant_17661_compound_4684>; <http://rdf.rhea-db.org/Participant_17661_compound_4684> rh:compound <http://rdf.rhea-db.org/Compound_4684>; compound rh:accession""}]"	"[{""id"": ""RHEA:17662"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinate + ATP + CoA => succinyl-CoA + ADP + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/17662""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-035_9589eb99d6f0	RHEA:17662	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17662	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:17662"", ""source_assertion"": ""Rhea directed reaction 17662 places CHEBI:456216 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/17662> rh:products <http://rdf.rhea-db.org/17661_R>; <http://rdf.rhea-db.org/17661_R> rh:contains1 <http://rdf.rhea-db.org/Participant_17661_compound_2710>; <http://rdf.rhea-db.org/Participant_17661_compound_2710> rh:compound <http://rdf.rhea-db.org/Compound_2710>; compound rh:accession""}]"	"[{""id"": ""RHEA:17662"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinate + ATP + CoA => succinyl-CoA + ADP + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/17662""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-036_0ef1d37dfa84	RHEA:17662	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17662	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:17662"", ""source_assertion"": ""Rhea directed reaction 17662 places CHEBI:43474 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/17662> rh:products <http://rdf.rhea-db.org/17661_R>; <http://rdf.rhea-db.org/17661_R> rh:contains1 <http://rdf.rhea-db.org/Participant_17661_compound_5518>; <http://rdf.rhea-db.org/Participant_17661_compound_5518> rh:compound <http://rdf.rhea-db.org/Compound_5518>; compound rh:accession""}]"	"[{""id"": ""RHEA:17662"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinate + ATP + CoA => succinyl-CoA + ADP + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/17662""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-037_777fca76fba3	CHEBI:57292	pathwaymech:consumes	RHEA:26452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26452	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26452"", ""source_assertion"": ""Rhea directed reaction 26452 places CHEBI:57292 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26452> rh:substrates <http://rdf.rhea-db.org/26450_R>; <http://rdf.rhea-db.org/26450_R> rh:contains1 <http://rdf.rhea-db.org/Participant_26450_compound_4684>; <http://rdf.rhea-db.org/Participant_26450_compound_4684> rh:compound <http://rdf.rhea-db.org/Compound_4684>; compound rh:accession""}]"	"[{""id"": ""RHEA:26452"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinyl-CoA + NADPH + H(+) => succinate semialdehyde + NADP(+) + CoA"", ""url"": ""https://www.rhea-db.org/rhea/26452""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-038_2b7189079321	CHEBI:57783	pathwaymech:consumes	RHEA:26452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26452	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26452"", ""source_assertion"": ""Rhea directed reaction 26452 places CHEBI:57783 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26452> rh:substrates <http://rdf.rhea-db.org/26450_R>; <http://rdf.rhea-db.org/26450_R> rh:contains1 <http://rdf.rhea-db.org/Participant_26450_compound_3438>; <http://rdf.rhea-db.org/Participant_26450_compound_3438> rh:compound <http://rdf.rhea-db.org/Compound_3438>; compound rh:accession""}]"	"[{""id"": ""RHEA:26452"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinyl-CoA + NADPH + H(+) => succinate semialdehyde + NADP(+) + CoA"", ""url"": ""https://www.rhea-db.org/rhea/26452""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-039_f790e52bc923	CHEBI:15378	pathwaymech:consumes	RHEA:26452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26452	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26452"", ""source_assertion"": ""Rhea directed reaction 26452 places CHEBI:15378 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26452> rh:substrates <http://rdf.rhea-db.org/26450_R>; <http://rdf.rhea-db.org/26450_R> rh:contains1 <http://rdf.rhea-db.org/Participant_26450_compound_3249>; <http://rdf.rhea-db.org/Participant_26450_compound_3249> rh:compound <http://rdf.rhea-db.org/Compound_3249>; compound rh:accession""}]"	"[{""id"": ""RHEA:26452"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinyl-CoA + NADPH + H(+) => succinate semialdehyde + NADP(+) + CoA"", ""url"": ""https://www.rhea-db.org/rhea/26452""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-040_4b85c1a72f0b	RHEA:26452	pathwaymech:produces	CHEBI:57706	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26452	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26452"", ""source_assertion"": ""Rhea directed reaction 26452 places CHEBI:57706 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26452> rh:products <http://rdf.rhea-db.org/26450_L>; <http://rdf.rhea-db.org/26450_L> rh:contains1 <http://rdf.rhea-db.org/Participant_26450_compound_4279>; <http://rdf.rhea-db.org/Participant_26450_compound_4279> rh:compound <http://rdf.rhea-db.org/Compound_4279>; compound rh:accession""}]"	"[{""id"": ""RHEA:26452"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinyl-CoA + NADPH + H(+) => succinate semialdehyde + NADP(+) + CoA"", ""url"": ""https://www.rhea-db.org/rhea/26452""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-041_5429af70f028	RHEA:26452	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26452	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26452"", ""source_assertion"": ""Rhea directed reaction 26452 places CHEBI:58349 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26452> rh:products <http://rdf.rhea-db.org/26450_L>; <http://rdf.rhea-db.org/26450_L> rh:contains1 <http://rdf.rhea-db.org/Participant_26450_compound_5188>; <http://rdf.rhea-db.org/Participant_26450_compound_5188> rh:compound <http://rdf.rhea-db.org/Compound_5188>; compound rh:accession""}]"	"[{""id"": ""RHEA:26452"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinyl-CoA + NADPH + H(+) => succinate semialdehyde + NADP(+) + CoA"", ""url"": ""https://www.rhea-db.org/rhea/26452""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-042_9791e8f2a9e4	RHEA:26452	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26452	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26452"", ""source_assertion"": ""Rhea directed reaction 26452 places CHEBI:57287 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26452> rh:products <http://rdf.rhea-db.org/26450_L>; <http://rdf.rhea-db.org/26450_L> rh:contains1 <http://rdf.rhea-db.org/Participant_26450_compound_1264>; <http://rdf.rhea-db.org/Participant_26450_compound_1264> rh:compound <http://rdf.rhea-db.org/Compound_1264>; compound rh:accession""}]"	"[{""id"": ""RHEA:26452"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinyl-CoA + NADPH + H(+) => succinate semialdehyde + NADP(+) + CoA"", ""url"": ""https://www.rhea-db.org/rhea/26452""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-043_3f50d4ab8c09	CHEBI:57706	pathwaymech:consumes	RHEA:26383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26383	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26383"", ""source_assertion"": ""Rhea directed reaction 26383 places CHEBI:57706 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26383> rh:substrates <http://rdf.rhea-db.org/26381_R>; <http://rdf.rhea-db.org/26381_R> rh:contains1 <http://rdf.rhea-db.org/Participant_26381_compound_4279>; <http://rdf.rhea-db.org/Participant_26381_compound_4279> rh:compound <http://rdf.rhea-db.org/Compound_4279>; compound rh:accession""}]"	"[{""id"": ""RHEA:26383"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinate semialdehyde + NADPH + H(+) => 4-hydroxybutanoate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/26383""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-044_d00282e48111	CHEBI:57783	pathwaymech:consumes	RHEA:26383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26383	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26383"", ""source_assertion"": ""Rhea directed reaction 26383 places CHEBI:57783 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26383> rh:substrates <http://rdf.rhea-db.org/26381_R>; <http://rdf.rhea-db.org/26381_R> rh:contains1 <http://rdf.rhea-db.org/Participant_26381_compound_3438>; <http://rdf.rhea-db.org/Participant_26381_compound_3438> rh:compound <http://rdf.rhea-db.org/Compound_3438>; compound rh:accession""}]"	"[{""id"": ""RHEA:26383"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinate semialdehyde + NADPH + H(+) => 4-hydroxybutanoate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/26383""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-045_48906dfb1c5c	CHEBI:15378	pathwaymech:consumes	RHEA:26383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26383	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26383"", ""source_assertion"": ""Rhea directed reaction 26383 places CHEBI:15378 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26383> rh:substrates <http://rdf.rhea-db.org/26381_R>; <http://rdf.rhea-db.org/26381_R> rh:contains1 <http://rdf.rhea-db.org/Participant_26381_compound_3249>; <http://rdf.rhea-db.org/Participant_26381_compound_3249> rh:compound <http://rdf.rhea-db.org/Compound_3249>; compound rh:accession""}]"	"[{""id"": ""RHEA:26383"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinate semialdehyde + NADPH + H(+) => 4-hydroxybutanoate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/26383""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-046_21036c9dc521	RHEA:26383	pathwaymech:produces	CHEBI:16724	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26383	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26383"", ""source_assertion"": ""Rhea directed reaction 26383 places CHEBI:16724 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26383> rh:products <http://rdf.rhea-db.org/26381_L>; <http://rdf.rhea-db.org/26381_L> rh:contains1 <http://rdf.rhea-db.org/Participant_26381_compound_5278>; <http://rdf.rhea-db.org/Participant_26381_compound_5278> rh:compound <http://rdf.rhea-db.org/Compound_5278>; compound rh:accession""}]"	"[{""id"": ""RHEA:26383"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinate semialdehyde + NADPH + H(+) => 4-hydroxybutanoate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/26383""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-047_452fedbe951e	RHEA:26383	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26383	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26383"", ""source_assertion"": ""Rhea directed reaction 26383 places CHEBI:58349 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26383> rh:products <http://rdf.rhea-db.org/26381_L>; <http://rdf.rhea-db.org/26381_L> rh:contains1 <http://rdf.rhea-db.org/Participant_26381_compound_5188>; <http://rdf.rhea-db.org/Participant_26381_compound_5188> rh:compound <http://rdf.rhea-db.org/Compound_5188>; compound rh:accession""}]"	"[{""id"": ""RHEA:26383"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinate semialdehyde + NADPH + H(+) => 4-hydroxybutanoate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/26383""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-048_cba292b97eb5	CHEBI:16724	pathwaymech:consumes	RHEA:23129	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23129	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23129"", ""source_assertion"": ""Rhea directed reaction 23129 places CHEBI:16724 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/23129> rh:substrates <http://rdf.rhea-db.org/23128_L>; <http://rdf.rhea-db.org/23128_L> rh:contains1 <http://rdf.rhea-db.org/Participant_23128_compound_5278>; <http://rdf.rhea-db.org/Participant_23128_compound_5278> rh:compound <http://rdf.rhea-db.org/Compound_5278>; compound rh:accession""}]"	"[{""id"": ""RHEA:23129"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + AMP + diphosphate"", ""url"": ""https://www.rhea-db.org/rhea/23129""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-049_d794857f04db	CHEBI:30616	pathwaymech:consumes	RHEA:23129	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23129	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23129"", ""source_assertion"": ""Rhea directed reaction 23129 places CHEBI:30616 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/23129> rh:substrates <http://rdf.rhea-db.org/23128_L>; <http://rdf.rhea-db.org/23128_L> rh:contains1 <http://rdf.rhea-db.org/Participant_23128_compound_6372>; <http://rdf.rhea-db.org/Participant_23128_compound_6372> rh:compound <http://rdf.rhea-db.org/Compound_6372>; compound rh:accession""}]"	"[{""id"": ""RHEA:23129"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + AMP + diphosphate"", ""url"": ""https://www.rhea-db.org/rhea/23129""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-050_ef1f07159529	CHEBI:57287	pathwaymech:consumes	RHEA:23129	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23129	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23129"", ""source_assertion"": ""Rhea directed reaction 23129 places CHEBI:57287 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/23129> rh:substrates <http://rdf.rhea-db.org/23128_L>; <http://rdf.rhea-db.org/23128_L> rh:contains1 <http://rdf.rhea-db.org/Participant_23128_compound_1264>; <http://rdf.rhea-db.org/Participant_23128_compound_1264> rh:compound <http://rdf.rhea-db.org/Compound_1264>; compound rh:accession""}]"	"[{""id"": ""RHEA:23129"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + AMP + diphosphate"", ""url"": ""https://www.rhea-db.org/rhea/23129""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-051_2064d3057b1c	RHEA:23129	pathwaymech:produces	CHEBI:58574	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23129	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23129"", ""source_assertion"": ""Rhea directed reaction 23129 places CHEBI:58574 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/23129> rh:products <http://rdf.rhea-db.org/23128_R>; <http://rdf.rhea-db.org/23128_R> rh:contains1 <http://rdf.rhea-db.org/Participant_23128_compound_6032>; <http://rdf.rhea-db.org/Participant_23128_compound_6032> rh:compound <http://rdf.rhea-db.org/Compound_6032>; compound rh:accession""}]"	"[{""id"": ""RHEA:23129"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + AMP + diphosphate"", ""url"": ""https://www.rhea-db.org/rhea/23129""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-052_6ae091501879	RHEA:23129	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23129	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23129"", ""source_assertion"": ""Rhea directed reaction 23129 places CHEBI:456215 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/23129> rh:products <http://rdf.rhea-db.org/23128_R>; <http://rdf.rhea-db.org/23128_R> rh:contains1 <http://rdf.rhea-db.org/Participant_23128_compound_2590>; <http://rdf.rhea-db.org/Participant_23128_compound_2590> rh:compound <http://rdf.rhea-db.org/Compound_2590>; compound rh:accession""}]"	"[{""id"": ""RHEA:23129"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + AMP + diphosphate"", ""url"": ""https://www.rhea-db.org/rhea/23129""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-053_1f6bbbbda4ba	RHEA:23129	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23129	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23129"", ""source_assertion"": ""Rhea directed reaction 23129 places CHEBI:33019 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/23129> rh:products <http://rdf.rhea-db.org/23128_R>; <http://rdf.rhea-db.org/23128_R> rh:contains1 <http://rdf.rhea-db.org/Participant_23128_compound_2106>; <http://rdf.rhea-db.org/Participant_23128_compound_2106> rh:compound <http://rdf.rhea-db.org/Compound_2106>; compound rh:accession""}]"	"[{""id"": ""RHEA:23129"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + AMP + diphosphate"", ""url"": ""https://www.rhea-db.org/rhea/23129""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-054_50fe0b65c627	CHEBI:58574	pathwaymech:consumes	RHEA:26531	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26531	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26531"", ""source_assertion"": ""Rhea directed reaction 26531 places CHEBI:58574 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26531> rh:substrates <http://rdf.rhea-db.org/26530_L>; <http://rdf.rhea-db.org/26530_L> rh:contains1 <http://rdf.rhea-db.org/Participant_26530_compound_6032>; <http://rdf.rhea-db.org/Participant_26530_compound_6032> rh:compound <http://rdf.rhea-db.org/Compound_6032>; compound rh:accession""}]"	"[{""id"": ""RHEA:26531"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""4-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"", ""url"": ""https://www.rhea-db.org/rhea/26531""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-055_000f6c36f691	RHEA:26531	pathwaymech:produces	CHEBI:57332	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26531	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26531"", ""source_assertion"": ""Rhea directed reaction 26531 places CHEBI:57332 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26531> rh:products <http://rdf.rhea-db.org/26530_R>; <http://rdf.rhea-db.org/26530_R> rh:contains1 <http://rdf.rhea-db.org/Participant_26530_compound_2633>; <http://rdf.rhea-db.org/Participant_26530_compound_2633> rh:compound <http://rdf.rhea-db.org/Compound_2633>; compound rh:accession""}]"	"[{""id"": ""RHEA:26531"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""4-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"", ""url"": ""https://www.rhea-db.org/rhea/26531""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-056_ab9f3721e7f8	RHEA:26531	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26531	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26531"", ""source_assertion"": ""Rhea directed reaction 26531 places CHEBI:15377 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26531> rh:products <http://rdf.rhea-db.org/26530_R>; <http://rdf.rhea-db.org/26530_R> rh:contains1 <http://rdf.rhea-db.org/Participant_26530_compound_1283>; <http://rdf.rhea-db.org/Participant_26530_compound_1283> rh:compound <http://rdf.rhea-db.org/Compound_1283>; compound rh:accession""}]"	"[{""id"": ""RHEA:26531"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""4-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"", ""url"": ""https://www.rhea-db.org/rhea/26531""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-057_bcdc936f64a4	CHEBI:57332	pathwaymech:consumes	RHEA:26560	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26560	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26560"", ""source_assertion"": ""Rhea directed reaction 26560 places CHEBI:57332 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26560> rh:substrates <http://rdf.rhea-db.org/26558_R>; <http://rdf.rhea-db.org/26558_R> rh:contains1 <http://rdf.rhea-db.org/Participant_26558_compound_2633>; <http://rdf.rhea-db.org/Participant_26558_compound_2633> rh:compound <http://rdf.rhea-db.org/Compound_2633>; compound rh:accession""}]"	"[{""id"": ""RHEA:26560"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(2E)-butenoyl-CoA + H2O => (3S)-3-hydroxybutanoyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/26560""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-058_c45a3177bdfd	CHEBI:15377	pathwaymech:consumes	RHEA:26560	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26560	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26560"", ""source_assertion"": ""Rhea directed reaction 26560 places CHEBI:15377 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26560> rh:substrates <http://rdf.rhea-db.org/26558_R>; <http://rdf.rhea-db.org/26558_R> rh:contains1 <http://rdf.rhea-db.org/Participant_26558_compound_1283>; <http://rdf.rhea-db.org/Participant_26558_compound_1283> rh:compound <http://rdf.rhea-db.org/Compound_1283>; compound rh:accession""}]"	"[{""id"": ""RHEA:26560"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(2E)-butenoyl-CoA + H2O => (3S)-3-hydroxybutanoyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/26560""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-059_b83bb3fb1703	RHEA:26560	pathwaymech:produces	CHEBI:57316	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26560	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26560"", ""source_assertion"": ""Rhea directed reaction 26560 places CHEBI:57316 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26560> rh:products <http://rdf.rhea-db.org/26558_L>; <http://rdf.rhea-db.org/26558_L> rh:contains1 <http://rdf.rhea-db.org/Participant_26558_compound_2192>; <http://rdf.rhea-db.org/Participant_26558_compound_2192> rh:compound <http://rdf.rhea-db.org/Compound_2192>; compound rh:accession""}]"	"[{""id"": ""RHEA:26560"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(2E)-butenoyl-CoA + H2O => (3S)-3-hydroxybutanoyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/26560""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-060_d124d6c46c56	CHEBI:57316	pathwaymech:consumes	RHEA:30800	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30800	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:30800"", ""source_assertion"": ""Rhea directed reaction 30800 places CHEBI:57316 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/30800> rh:substrates <http://rdf.rhea-db.org/30799_L>; <http://rdf.rhea-db.org/30799_L> rh:contains1 <http://rdf.rhea-db.org/Participant_30799_compound_2192>; <http://rdf.rhea-db.org/Participant_30799_compound_2192> rh:compound <http://rdf.rhea-db.org/Compound_2192>; compound rh:accession""}]"	"[{""id"": ""RHEA:30800"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(3S)-3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + NADH + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/30800""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-061_94e671384f5b	CHEBI:57540	pathwaymech:consumes	RHEA:30800	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30800	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:30800"", ""source_assertion"": ""Rhea directed reaction 30800 places CHEBI:57540 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/30800> rh:substrates <http://rdf.rhea-db.org/30799_L>; <http://rdf.rhea-db.org/30799_L> rh:contains1 <http://rdf.rhea-db.org/Participant_30799_compound_3484>; <http://rdf.rhea-db.org/Participant_30799_compound_3484> rh:compound <http://rdf.rhea-db.org/Compound_3484>; compound rh:accession""}]"	"[{""id"": ""RHEA:30800"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(3S)-3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + NADH + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/30800""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-062_5d6f557b124d	RHEA:30800	pathwaymech:produces	CHEBI:57286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30800	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:30800"", ""source_assertion"": ""Rhea directed reaction 30800 places CHEBI:57286 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/30800> rh:products <http://rdf.rhea-db.org/30799_R>; <http://rdf.rhea-db.org/30799_R> rh:contains1 <http://rdf.rhea-db.org/Participant_30799_compound_4872>; <http://rdf.rhea-db.org/Participant_30799_compound_4872> rh:compound <http://rdf.rhea-db.org/Compound_4872>; compound rh:accession""}]"	"[{""id"": ""RHEA:30800"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(3S)-3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + NADH + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/30800""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-063_ca093b09d63b	RHEA:30800	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30800	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:30800"", ""source_assertion"": ""Rhea directed reaction 30800 places CHEBI:57945 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/30800> rh:products <http://rdf.rhea-db.org/30799_R>; <http://rdf.rhea-db.org/30799_R> rh:contains1 <http://rdf.rhea-db.org/Participant_30799_compound_1650>; <http://rdf.rhea-db.org/Participant_30799_compound_1650> rh:compound <http://rdf.rhea-db.org/Compound_1650>; compound rh:accession""}]"	"[{""id"": ""RHEA:30800"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(3S)-3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + NADH + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/30800""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-064_eb2eb2153f8c	RHEA:30800	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30800	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:30800"", ""source_assertion"": ""Rhea directed reaction 30800 places CHEBI:15378 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/30800> rh:products <http://rdf.rhea-db.org/30799_R>; <http://rdf.rhea-db.org/30799_R> rh:contains1 <http://rdf.rhea-db.org/Participant_30799_compound_3249>; <http://rdf.rhea-db.org/Participant_30799_compound_3249> rh:compound <http://rdf.rhea-db.org/Compound_3249>; compound rh:accession""}]"	"[{""id"": ""RHEA:30800"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(3S)-3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + NADH + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/30800""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-065_9f7c40ca6210	CHEBI:57286	pathwaymech:consumes	RHEA:21038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21038	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:21038"", ""source_assertion"": ""Rhea directed reaction 21038 places CHEBI:57286 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/21038> rh:substrates <http://rdf.rhea-db.org/21036_R>; <http://rdf.rhea-db.org/21036_R> rh:contains1 <http://rdf.rhea-db.org/Participant_21036_compound_4872>; <http://rdf.rhea-db.org/Participant_21036_compound_4872> rh:compound <http://rdf.rhea-db.org/Compound_4872>; compound rh:accession""}]"	"[{""id"": ""RHEA:21038"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""acetoacetyl-CoA + CoA => 2 acetyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/21038""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-066_763d95e14013	CHEBI:57287	pathwaymech:consumes	RHEA:21038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21038	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:21038"", ""source_assertion"": ""Rhea directed reaction 21038 places CHEBI:57287 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/21038> rh:substrates <http://rdf.rhea-db.org/21036_R>; <http://rdf.rhea-db.org/21036_R> rh:contains1 <http://rdf.rhea-db.org/Participant_21036_compound_1264>; <http://rdf.rhea-db.org/Participant_21036_compound_1264> rh:compound <http://rdf.rhea-db.org/Compound_1264>; compound rh:accession""}]"	"[{""id"": ""RHEA:21038"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""acetoacetyl-CoA + CoA => 2 acetyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/21038""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-067_f874e01f27e8	RHEA:21038	pathwaymech:produces	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21038	Stoichiometric coefficient 2.	"[{""reference_id"": ""RHEA:21038"", ""source_assertion"": ""Rhea directed reaction 21038 places CHEBI:57288 on its products side with coefficient 2."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/21038> rh:products <http://rdf.rhea-db.org/21036_L>; <http://rdf.rhea-db.org/21036_L> rh:contains2 <http://rdf.rhea-db.org/Participant_21036_compound_4271>; <http://rdf.rhea-db.org/Participant_21036_compound_4271> rh:compound <http://rdf.rhea-db.org/Compound_4271>; compound rh:accession""}]"	"[{""id"": ""RHEA:21038"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""acetoacetyl-CoA + CoA => 2 acetyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/21038""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-068_ae4a572b4ae5	KEGG:R01196	BFO:0000050	KEGG:M00374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00374|PMID:19411323	Cycle step 1. Cell-extract activity; four alternative locus groups are proposed. Do not choose one exact complex or prove its composition from name matching. Rhea formal 2Fe-2S carrier class is not measured Tneu cluster identity; native KEGG uses generic ferredoxin. Preserve assay/carrier distinction.	"[{""reference_id"": ""KEGG:M00374"", ""source_assertion"": ""The complete module includes native KEGG:R01196; its fourteen reaction objects define the full cycle. The organism-specific step 1 is separately supported by the primary activity study, rather than inferred from module membership alone."", ""source_locator"": ""Original flatfile ENTRY M00374; REACTION R01196; DEFINITION""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Pyruvate-acceptor oxidoreductase was measured with methyl viologen; pyruvate-carboxyl 14CO2 exchange was also measured. These assays do not identify the physiological ferredoxin or select among the candidate locus groups."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[2]""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Figure 1 identifies cycle enzyme 1; Table 1 reports the corresponding activity in autotrophic T. neutrophilus extracts and lists candidate loci. Temperature-extrapolated values are distinguished from measured activities."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""]; //table[1] and its footnotes""}]"	"[{""id"": ""KEGG:M00374"", ""source_sha256"": ""80a88c6f6f2c6250aaf56a6f9a19c0c7109ca6ad5409a3eb2fd9c0f5aedfdb6e"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:25:31.010627+00:00; original response has no per-entry release designation"", ""title"": ""Dicarboxylate-hydroxybutyrate cycle"", ""url"": ""https://rest.kegg.jp/get/M00374""}, {""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-069_05a0ee04c67e	RHEA:11365	BFO:0000050	KEGG:M00374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00374|PMID:19411323|RHEA:11365	Cycle step 2. ATP/AMP + phosphate reaction; primary observes PEP formation with extract. Current protein assignment is annotation/candidate tier, not a purified construct.	"[{""reference_id"": ""KEGG:M00374"", ""source_assertion"": ""The complete module includes native KEGG:R00199; its fourteen reaction objects define the full cycle. The organism-specific step 2 is separately supported by the primary activity study, rather than inferred from module membership alone."", ""source_locator"": ""Original flatfile ENTRY M00374; REACTION R00199; DEFINITION""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Extract pyruvate-water dikinase formed PEP with ATP; a discontinuous PEP assay was used. This is the AMP/phosphate-forming reaction, not an inferred pyruvate-kinase reversal."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[3]""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Figure 1 identifies cycle enzyme 2; Table 1 reports the corresponding activity in autotrophic T. neutrophilus extracts and lists candidate loci. Temperature-extrapolated values are distinguished from measured activities."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""]; //table[1] and its footnotes""}, {""reference_id"": ""RHEA:11365"", ""source_assertion"": ""Rhea master 11364 explicitly includes directional member 11365; its current sides supply the selected chemical microstates. This grounds chemical orientation, not T. neutrophilus activity."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/11364> rh:directionalReaction <http://rdf.rhea-db.org/11365>; <http://rdf.rhea-db.org/11365> rh:substrates/rh:products/rdfs:label; official rhea-directions.tsv master 11364""}]"	"[{""id"": ""KEGG:M00374"", ""source_sha256"": ""80a88c6f6f2c6250aaf56a6f9a19c0c7109ca6ad5409a3eb2fd9c0f5aedfdb6e"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:25:31.010627+00:00; original response has no per-entry release designation"", ""title"": ""Dicarboxylate-hydroxybutyrate cycle"", ""url"": ""https://rest.kegg.jp/get/M00374""}, {""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:11365"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""pyruvate + ATP + H2O => phosphoenolpyruvate + AMP + phosphate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/11365""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-070_f39b66bcea57	RHEA:28372	BFO:0000050	KEGG:M00374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00374|PMID:19411323|RHEA:28372	Cycle step 3. Cell-extract direct activity; exact locus is a primary candidate/current HAMAP assignment. Mn2+ is present in assay, not automatically a demonstrated native occupancy requirement.	"[{""reference_id"": ""KEGG:M00374"", ""source_assertion"": ""The complete module includes native KEGG:R00345; its fourteen reaction objects define the full cycle. The organism-specific step 3 is separately supported by the primary activity study, rather than inferred from module membership alone."", ""source_locator"": ""Original flatfile ENTRY M00374; REACTION R00345; DEFINITION""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""PEP carboxylase activity was measured by coupled NADH oxidation and radiochemical bicarbonate incorporation. MnCl2 was an assay component, not a demonstrated native metal-occupancy result."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[6]""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Figure 1 identifies cycle enzyme 3; Table 1 reports the corresponding activity in autotrophic T. neutrophilus extracts and lists candidate loci. Temperature-extrapolated values are distinguished from measured activities."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""]; //table[1] and its footnotes""}, {""reference_id"": ""RHEA:28372"", ""source_assertion"": ""Rhea master 28370 explicitly includes directional member 28372; its current sides supply the selected chemical microstates. This grounds chemical orientation, not T. neutrophilus activity."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/28370> rh:directionalReaction <http://rdf.rhea-db.org/28372>; <http://rdf.rhea-db.org/28372> rh:substrates/rh:products/rdfs:label; official rhea-directions.tsv master 28370""}]"	"[{""id"": ""KEGG:M00374"", ""source_sha256"": ""80a88c6f6f2c6250aaf56a6f9a19c0c7109ca6ad5409a3eb2fd9c0f5aedfdb6e"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:25:31.010627+00:00; original response has no per-entry release designation"", ""title"": ""Dicarboxylate-hydroxybutyrate cycle"", ""url"": ""https://rest.kegg.jp/get/M00374""}, {""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:28372"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""phosphoenolpyruvate + hydrogencarbonate => oxaloacetate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/28372""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-071_7fcef7077d89	RHEA:21434	BFO:0000050	KEGG:M00374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00374|PMID:19411323|RHEA:21434	Cycle step 4. NADH-dependent extract assay; use the NADH-specific reaction, not the preferred NADPH function of different I. hospitalis Mdh.	"[{""reference_id"": ""KEGG:M00374"", ""source_assertion"": ""The complete module includes native KEGG:R00342; its fourteen reaction objects define the full cycle. The organism-specific step 4 is separately supported by the primary activity study, rather than inferred from module membership alone."", ""source_locator"": ""Original flatfile ENTRY M00374; REACTION R00342; DEFINITION""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Extract malate dehydrogenase was measured by oxaloacetate-dependent NADH oxidation. This record preserves that NADH-dependent chemistry."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[8]""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Figure 1 identifies cycle enzyme 4; Table 1 reports the corresponding activity in autotrophic T. neutrophilus extracts and lists candidate loci. Temperature-extrapolated values are distinguished from measured activities."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""]; //table[1] and its footnotes""}, {""reference_id"": ""RHEA:21434"", ""source_assertion"": ""Rhea master 21432 explicitly includes directional member 21434; its current sides supply the selected chemical microstates. This grounds chemical orientation, not T. neutrophilus activity."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/21432> rh:directionalReaction <http://rdf.rhea-db.org/21434>; <http://rdf.rhea-db.org/21434> rh:substrates/rh:products/rdfs:label; official rhea-directions.tsv master 21432""}]"	"[{""id"": ""KEGG:M00374"", ""source_sha256"": ""80a88c6f6f2c6250aaf56a6f9a19c0c7109ca6ad5409a3eb2fd9c0f5aedfdb6e"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:25:31.010627+00:00; original response has no per-entry release designation"", ""title"": ""Dicarboxylate-hydroxybutyrate cycle"", ""url"": ""https://rest.kegg.jp/get/M00374""}, {""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:21434"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""oxaloacetate + NADH + H(+) => (S)-malate + NAD(+)"", ""url"": ""https://www.rhea-db.org/rhea/21434""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-072_ca5264e7a7f4	RHEA:12461	BFO:0000050	KEGG:M00374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00374|PMID:19411323|RHEA:12461	Cycle step 5. Cell-extract activity, candidate two-subunit locus. Current names are tartrate/fumarate-family proteins, including submitted EC4.2.1.32; no direct purified Tneu assembly or obligatory stoichiometry established.	"[{""reference_id"": ""KEGG:M00374"", ""source_assertion"": ""The complete module includes native KEGG:R01082; its fourteen reaction objects define the full cycle. The organism-specific step 5 is separately supported by the primary activity study, rather than inferred from module membership alone."", ""source_locator"": ""Original flatfile ENTRY M00374; REACTION R01082; DEFINITION""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Extract fumarate hydratase was assayed anaerobically with D,L-malate. The selected stereospecific physiological malate reaction is separately grounded in Rhea."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[9]""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Figure 1 identifies cycle enzyme 5; Table 1 reports the corresponding activity in autotrophic T. neutrophilus extracts and lists candidate loci. Temperature-extrapolated values are distinguished from measured activities."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""]; //table[1] and its footnotes""}, {""reference_id"": ""RHEA:12461"", ""source_assertion"": ""Rhea master 12460 explicitly includes directional member 12461; its current sides supply the selected chemical microstates. This grounds chemical orientation, not T. neutrophilus activity."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/12460> rh:directionalReaction <http://rdf.rhea-db.org/12461>; <http://rdf.rhea-db.org/12461> rh:substrates/rh:products/rdfs:label; official rhea-directions.tsv master 12460""}]"	"[{""id"": ""KEGG:M00374"", ""source_sha256"": ""80a88c6f6f2c6250aaf56a6f9a19c0c7109ca6ad5409a3eb2fd9c0f5aedfdb6e"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:25:31.010627+00:00; original response has no per-entry release designation"", ""title"": ""Dicarboxylate-hydroxybutyrate cycle"", ""url"": ""https://rest.kegg.jp/get/M00374""}, {""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:12461"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(S)-malate => fumarate + H2O"", ""url"": ""https://www.rhea-db.org/rhea/12461""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-073_ab4779a5f654	RHEA:16359	BFO:0000050	KEGG:M00374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00374|PMID:19411323|PMID:21169482|RHEA:16359	Cycle step 6. Reduced methyl viologen works in vitro; NAD(P)H does not. Soluble activity and putative induced subunits are supported. Disposition KEGG quinol equation R02164; use source-issued generic A/AH2 Rhea chemistry with an unknown physiological-donor qualification. No quinol or particular ferredoxin claim.	"[{""reference_id"": ""KEGG:M00374"", ""source_assertion"": ""The complete module includes native KEGG:R02164; its fourteen reaction objects define the full cycle. The organism-specific step 6 is separately supported by the primary activity study, rather than inferred from module membership alone."", ""source_locator"": ""Original flatfile ENTRY M00374; REACTION R02164; DEFINITION""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Extract fumarate reductase used reduced methyl viologen. This assay does not establish quinol or a specific ferredoxin as its physiological electron donor."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[10]""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Figure 1 identifies cycle enzyme 6; Table 1 reports the corresponding activity in autotrophic T. neutrophilus extracts and lists candidate loci. Temperature-extrapolated values are distinguished from measured activities."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""]; //table[1] and its footnotes""}, {""reference_id"": ""RHEA:16359"", ""source_assertion"": ""Rhea master 16357 explicitly includes directional member 16359; its current sides supply the selected chemical microstates. This grounds chemical orientation, not T. neutrophilus activity."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/16357> rh:directionalReaction <http://rdf.rhea-db.org/16359>; <http://rdf.rhea-db.org/16359> rh:substrates/rh:products/rdfs:label; official rhea-directions.tsv master 16357""}, {""reference_id"": ""PMID:21169482"", ""source_assertion"": ""T. neutrophilus fumarate reductase was soluble and active with reduced viologens but not NAD(P)H. Tneu_0423/0424 are putative induced subunits. Generic A/AH2 retains the unresolved physiological donor instead of native module quinol chemistry."", ""source_locator"": ""PMC3067573 HTML //*[@id=\""sec27\""]/p[1]""}]"	"[{""id"": ""KEGG:M00374"", ""source_sha256"": ""80a88c6f6f2c6250aaf56a6f9a19c0c7109ca6ad5409a3eb2fd9c0f5aedfdb6e"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:25:31.010627+00:00; original response has no per-entry release designation"", ""title"": ""Dicarboxylate-hydroxybutyrate cycle"", ""url"": ""https://rest.kegg.jp/get/M00374""}, {""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""PMID:21169482"", ""source_sha256"": ""0e10b7fd643550058542e4318f2d04fb8069d784f0d0d62c76aa2dada93f038e"", ""source_version"": ""2011 original article HTML; retrieved 2026-10-11"", ""title"": ""Identification of Missing Genes and Enzymes for Autotrophic Carbon Fixation in Crenarchaeota"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3067573/""}, {""id"": ""RHEA:16359"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""fumarate + AH2 => succinate + A"", ""url"": ""https://www.rhea-db.org/rhea/16359""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-074_ca939a87d6d6	RHEA:17662	BFO:0000050	KEGG:M00374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00374|PMID:19411323|RHEA:17662	Cycle step 7. Direct extract reaction with M. sedula coupling enzyme. Current HAMAP subunits are inferred; do not attribute the coupling enzyme or its NADPH to Tneu synthetase.	"[{""reference_id"": ""KEGG:M00374"", ""source_assertion"": ""The complete module includes native KEGG:R00405; its fourteen reaction objects define the full cycle. The organism-specific step 7 is separately supported by the primary activity study, rather than inferred from module membership alone."", ""source_locator"": ""Original flatfile ENTRY M00374; REACTION R00405; DEFINITION""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Extract succinyl-CoA synthetase used succinate, ATP and CoA, coupled to recombinant M. sedula reductase. NADPH belonged to the coupling reaction, not the synthetase stoichiometry."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[11]""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Figure 1 identifies cycle enzyme 7; Table 1 reports the corresponding activity in autotrophic T. neutrophilus extracts and lists candidate loci. Temperature-extrapolated values are distinguished from measured activities."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""]; //table[1] and its footnotes""}, {""reference_id"": ""RHEA:17662"", ""source_assertion"": ""Rhea master 17661 explicitly includes directional member 17662; its current sides supply the selected chemical microstates. This grounds chemical orientation, not T. neutrophilus activity."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/17661> rh:directionalReaction <http://rdf.rhea-db.org/17662>; <http://rdf.rhea-db.org/17662> rh:substrates/rh:products/rdfs:label; official rhea-directions.tsv master 17661""}]"	"[{""id"": ""KEGG:M00374"", ""source_sha256"": ""80a88c6f6f2c6250aaf56a6f9a19c0c7109ca6ad5409a3eb2fd9c0f5aedfdb6e"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:25:31.010627+00:00; original response has no per-entry release designation"", ""title"": ""Dicarboxylate-hydroxybutyrate cycle"", ""url"": ""https://rest.kegg.jp/get/M00374""}, {""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:17662"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinate + ATP + CoA => succinyl-CoA + ADP + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/17662""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-075_4e121e3b5c84	RHEA:26452	BFO:0000050	KEGG:M00374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00374|PMID:19411323|RHEA:26452	Cycle step 8. Direct purified N-terminal His10-tagged Tneu_0421 expressed in E. coli. NADPH preferred, NADH10%; no malonyl-/methylmalonyl-CoA activity. Current homotetramer is ARBA inference, not the measured experiment. Exact I. hospitalis function/donor cannot be transferred.	"[{""reference_id"": ""KEGG:M00374"", ""source_assertion"": ""The complete module includes native KEGG:R09280; its fourteen reaction objects define the full cycle. The organism-specific step 8 is separately supported by the primary activity study, rather than inferred from module membership alone."", ""source_locator"": ""Original flatfile ENTRY M00374; REACTION R09280; DEFINITION""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Extract succinyl-CoA reductase was measured with succinyl-CoA and NADPH. The T. neutrophilus reaction is distinguished from the donor-unspecified I. hospitalis activity."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[12]""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Figure 1 identifies cycle enzyme 8; Table 1 reports the corresponding activity in autotrophic T. neutrophilus extracts and lists candidate loci. Temperature-extrapolated values are distinguished from measured activities."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""]; //table[1] and its footnotes""}, {""reference_id"": ""RHEA:26452"", ""source_assertion"": ""Rhea master 26450 explicitly includes directional member 26452; its current sides supply the selected chemical microstates. This grounds chemical orientation, not T. neutrophilus activity."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26450> rh:directionalReaction <http://rdf.rhea-db.org/26452>; <http://rdf.rhea-db.org/26452> rh:substrates/rh:products/rdfs:label; official rhea-directions.tsv master 26450""}]"	"[{""id"": ""KEGG:M00374"", ""source_sha256"": ""80a88c6f6f2c6250aaf56a6f9a19c0c7109ca6ad5409a3eb2fd9c0f5aedfdb6e"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:25:31.010627+00:00; original response has no per-entry release designation"", ""title"": ""Dicarboxylate-hydroxybutyrate cycle"", ""url"": ""https://rest.kegg.jp/get/M00374""}, {""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:26452"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinyl-CoA + NADPH + H(+) => succinate semialdehyde + NADP(+) + CoA"", ""url"": ""https://www.rhea-db.org/rhea/26452""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-076_159b7092e353	RHEA:26383	BFO:0000050	KEGG:M00374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00374|PMID:19411323|RHEA:26383	Cycle step 9. Direct purified N-terminal His10-tagged Tneu_0419. NADPH is supported; Zn2+ in current UniProt is ARBA/RuleBase inference, not direct primary metal analysis.	"[{""reference_id"": ""KEGG:M00374"", ""source_assertion"": ""The complete module includes native KEGG:R09281; its fourteen reaction objects define the full cycle. The organism-specific step 9 is separately supported by the primary activity study, rather than inferred from module membership alone."", ""source_locator"": ""Original flatfile ENTRY M00374; REACTION R09281; DEFINITION""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Extract succinic semialdehyde reductase was measured with succinic semialdehyde and NADPH."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[12]""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Figure 1 identifies cycle enzyme 9; Table 1 reports the corresponding activity in autotrophic T. neutrophilus extracts and lists candidate loci. Temperature-extrapolated values are distinguished from measured activities."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""]; //table[1] and its footnotes""}, {""reference_id"": ""RHEA:26383"", ""source_assertion"": ""Rhea master 26381 explicitly includes directional member 26383; its current sides supply the selected chemical microstates. This grounds chemical orientation, not T. neutrophilus activity."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26381> rh:directionalReaction <http://rdf.rhea-db.org/26383>; <http://rdf.rhea-db.org/26383> rh:substrates/rh:products/rdfs:label; official rhea-directions.tsv master 26381""}]"	"[{""id"": ""KEGG:M00374"", ""source_sha256"": ""80a88c6f6f2c6250aaf56a6f9a19c0c7109ca6ad5409a3eb2fd9c0f5aedfdb6e"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:25:31.010627+00:00; original response has no per-entry release designation"", ""title"": ""Dicarboxylate-hydroxybutyrate cycle"", ""url"": ""https://rest.kegg.jp/get/M00374""}, {""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:26383"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinate semialdehyde + NADPH + H(+) => 4-hydroxybutanoate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/26383""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-077_d5b95246a4b7	RHEA:23129	BFO:0000050	KEGG:M00374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00374|PMID:19411323|RHEA:23129	Cycle step 10. Purified recombinant protein acts on4HB; low activity linked to Lys594 acetylation in E. coli expression. Native archaeal regulation by acetylation is not established. This verified Tneu ligase must not inherit the failed I. hospitalis0256/0257 assignment.	"[{""reference_id"": ""KEGG:M00374"", ""source_assertion"": ""The complete module includes native KEGG:R09279; its fourteen reaction objects define the full cycle. The organism-specific step 10 is separately supported by the primary activity study, rather than inferred from module membership alone."", ""source_locator"": ""Original flatfile ENTRY M00374; REACTION R09279; DEFINITION""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""4-Hydroxybutyrate-CoA ligase was measured with 4-hydroxybutyrate, ATP and CoA by discontinuous CoA consumption."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[13]""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Figure 1 identifies cycle enzyme 10; Table 1 reports the corresponding activity in autotrophic T. neutrophilus extracts and lists candidate loci. Temperature-extrapolated values are distinguished from measured activities."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""]; //table[1] and its footnotes""}, {""reference_id"": ""RHEA:23129"", ""source_assertion"": ""Rhea master 23128 explicitly includes directional member 23129; its current sides supply the selected chemical microstates. This grounds chemical orientation, not T. neutrophilus activity."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/23128> rh:directionalReaction <http://rdf.rhea-db.org/23129>; <http://rdf.rhea-db.org/23129> rh:substrates/rh:products/rdfs:label; official rhea-directions.tsv master 23128""}]"	"[{""id"": ""KEGG:M00374"", ""source_sha256"": ""80a88c6f6f2c6250aaf56a6f9a19c0c7109ca6ad5409a3eb2fd9c0f5aedfdb6e"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:25:31.010627+00:00; original response has no per-entry release designation"", ""title"": ""Dicarboxylate-hydroxybutyrate cycle"", ""url"": ""https://rest.kegg.jp/get/M00374""}, {""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:23129"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + AMP + diphosphate"", ""url"": ""https://www.rhea-db.org/rhea/23129""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-078_8f1fa711170a	RHEA:26531	BFO:0000050	KEGG:M00374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00374|PMID:19411323|RHEA:26531	Cycle step 11. Direct extract conversion/coupled assay plus sequence-based Tneu_0422 attribution. No purified Tneu cofactor or assembly measurement in these sources; do not transfer clostridial Fe-S/FAD occupancy or oligomeric data as direct Tneu evidence.	"[{""reference_id"": ""KEGG:M00374"", ""source_assertion"": ""The complete module includes native KEGG:R10782; its fourteen reaction objects define the full cycle. The organism-specific step 11 is separately supported by the primary activity study, rather than inferred from module membership alone."", ""source_locator"": ""Original flatfile ENTRY M00374; REACTION R10782; DEFINITION""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Extract 4-hydroxybutyryl-CoA dehydratase was assayed by detecting crotonyl-CoA with an added R. sphaeroides coupling enzyme; coupling-enzyme cofactors are not transferred."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[14]""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Figure 1 identifies cycle enzyme 11; Table 1 reports the corresponding activity in autotrophic T. neutrophilus extracts and lists candidate loci. Temperature-extrapolated values are distinguished from measured activities."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""]; //table[1] and its footnotes""}, {""reference_id"": ""RHEA:26531"", ""source_assertion"": ""Rhea master 26530 explicitly includes directional member 26531; its current sides supply the selected chemical microstates. This grounds chemical orientation, not T. neutrophilus activity."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26530> rh:directionalReaction <http://rdf.rhea-db.org/26531>; <http://rdf.rhea-db.org/26531> rh:substrates/rh:products/rdfs:label; official rhea-directions.tsv master 26530""}]"	"[{""id"": ""KEGG:M00374"", ""source_sha256"": ""80a88c6f6f2c6250aaf56a6f9a19c0c7109ca6ad5409a3eb2fd9c0f5aedfdb6e"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:25:31.010627+00:00; original response has no per-entry release designation"", ""title"": ""Dicarboxylate-hydroxybutyrate cycle"", ""url"": ""https://rest.kegg.jp/get/M00374""}, {""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:26531"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""4-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"", ""url"": ""https://www.rhea-db.org/rhea/26531""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-079_3b432298d09f	RHEA:26560	BFO:0000050	KEGG:M00374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00374|PMID:19411323|RHEA:26560	Cycle step 12. S-specific cell-extract activity is direct. The2011 purified bifunctional protein was Msed_0399; Tneu_0541 role is inferred from orthology/domain structure and unique candidate, not direct Tneu recombinant demonstration. Current monomer annotation is inferred.	"[{""reference_id"": ""KEGG:M00374"", ""source_assertion"": ""The complete module includes native KEGG:R03026; its fourteen reaction objects define the full cycle. The organism-specific step 12 is separately supported by the primary activity study, rather than inferred from module membership alone."", ""source_locator"": ""Original flatfile ENTRY M00374; REACTION R03026; DEFINITION""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Crotonyl-CoA hydratase was assayed in reverse with (R)- or (S)-3-hydroxybutyryl-CoA. Activity occurred only with the (S) substrate."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[15]""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Figure 1 identifies cycle enzyme 12; Table 1 reports the corresponding activity in autotrophic T. neutrophilus extracts and lists candidate loci. Temperature-extrapolated values are distinguished from measured activities."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""]; //table[1] and its footnotes""}, {""reference_id"": ""RHEA:26560"", ""source_assertion"": ""Rhea master 26558 explicitly includes directional member 26560; its current sides supply the selected chemical microstates. This grounds chemical orientation, not T. neutrophilus activity."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26558> rh:directionalReaction <http://rdf.rhea-db.org/26560>; <http://rdf.rhea-db.org/26560> rh:substrates/rh:products/rdfs:label; official rhea-directions.tsv master 26558""}]"	"[{""id"": ""KEGG:M00374"", ""source_sha256"": ""80a88c6f6f2c6250aaf56a6f9a19c0c7109ca6ad5409a3eb2fd9c0f5aedfdb6e"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:25:31.010627+00:00; original response has no per-entry release designation"", ""title"": ""Dicarboxylate-hydroxybutyrate cycle"", ""url"": ""https://rest.kegg.jp/get/M00374""}, {""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:26560"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(2E)-butenoyl-CoA + H2O => (3S)-3-hydroxybutanoyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/26560""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-080_42d7c0e3b356	RHEA:30800	BFO:0000050	KEGG:M00374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00374|PMID:19411323|RHEA:30800	Cycle step 13. NAD+ and S substrate supported in Tneu extract; NADP+ and R stereoisomer inactive. Same exact Tneu fusion-protein assignment limit as step12; no direct Msed construct transfer.	"[{""reference_id"": ""KEGG:M00374"", ""source_assertion"": ""The complete module includes native KEGG:R01975; its fourteen reaction objects define the full cycle. The organism-specific step 13 is separately supported by the primary activity study, rather than inferred from module membership alone."", ""source_locator"": ""Original flatfile ENTRY M00374; REACTION R01975; DEFINITION""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Extract (S)-3-hydroxybutyryl-CoA dehydrogenase reduced NAD+. No activity was detected with NADP+ or the (R) substrate."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[16]""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Figure 1 identifies cycle enzyme 13; Table 1 reports the corresponding activity in autotrophic T. neutrophilus extracts and lists candidate loci. Temperature-extrapolated values are distinguished from measured activities."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""]; //table[1] and its footnotes""}, {""reference_id"": ""RHEA:30800"", ""source_assertion"": ""Rhea master 30799 explicitly includes directional member 30800; its current sides supply the selected chemical microstates. This grounds chemical orientation, not T. neutrophilus activity."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/30799> rh:directionalReaction <http://rdf.rhea-db.org/30800>; <http://rdf.rhea-db.org/30800> rh:substrates/rh:products/rdfs:label; official rhea-directions.tsv master 30799""}]"	"[{""id"": ""KEGG:M00374"", ""source_sha256"": ""80a88c6f6f2c6250aaf56a6f9a19c0c7109ca6ad5409a3eb2fd9c0f5aedfdb6e"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:25:31.010627+00:00; original response has no per-entry release designation"", ""title"": ""Dicarboxylate-hydroxybutyrate cycle"", ""url"": ""https://rest.kegg.jp/get/M00374""}, {""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:30800"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(3S)-3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + NADH + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/30800""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-081_6fd4e0a13c12	RHEA:21038	BFO:0000050	KEGG:M00374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00374|PMID:19411323|RHEA:21038	Cycle step 14. Direct soluble N-terminal His10-tagged Tneu_0249 expressed in E. coli, purified thiolytic cleavage. No arbitrary standalone monomer sufficiency/complex ID.	"[{""reference_id"": ""KEGG:M00374"", ""source_assertion"": ""The complete module includes native KEGG:R00238; its fourteen reaction objects define the full cycle. The organism-specific step 14 is separately supported by the primary activity study, rather than inferred from module membership alone."", ""source_locator"": ""Original flatfile ENTRY M00374; REACTION R00238; DEFINITION""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Thiolase activity was measured by HPLC detection of acetyl-CoA from acetoacetyl-CoA and CoA."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[17]""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Figure 1 identifies cycle enzyme 14; Table 1 reports the corresponding activity in autotrophic T. neutrophilus extracts and lists candidate loci. Temperature-extrapolated values are distinguished from measured activities."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""]; //table[1] and its footnotes""}, {""reference_id"": ""RHEA:21038"", ""source_assertion"": ""Rhea master 21036 explicitly includes directional member 21038; its current sides supply the selected chemical microstates. This grounds chemical orientation, not T. neutrophilus activity."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/21036> rh:directionalReaction <http://rdf.rhea-db.org/21038>; <http://rdf.rhea-db.org/21038> rh:substrates/rh:products/rdfs:label; official rhea-directions.tsv master 21036""}]"	"[{""id"": ""KEGG:M00374"", ""source_sha256"": ""80a88c6f6f2c6250aaf56a6f9a19c0c7109ca6ad5409a3eb2fd9c0f5aedfdb6e"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:25:31.010627+00:00; original response has no per-entry release designation"", ""title"": ""Dicarboxylate-hydroxybutyrate cycle"", ""url"": ""https://rest.kegg.jp/get/M00374""}, {""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:21038"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""acetoacetyl-CoA + CoA => 2 acetyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/21038""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-082_14f97f043998	UniProtKB:B1Y8Q3	pathwaymech:enables	RHEA:11365	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19411323|UniProtKB:B1Y8Q3	Functional assignment of Tneu_1204; ATP/AMP + phosphate reaction; primary observes PEP formation with extract. Current protein assignment is annotation/candidate tier, not a purified construct.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Tneu_1204 is a candidate pyruvate-water dikinase in Table 1; the measured activity is from extract, not purified Tneu_1204."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[3]; (//table)[1] column Putative gene(s) in T. neutrophilus""}, {""reference_id"": ""UniProtKB:B1Y8Q3"", ""source_assertion"": ""This unreviewed entry identifies Tneu_1204 as UniProtKB:B1Y8Q3 in strain DSM 2338/V24Sta (taxon 444157). The locus/sequence bridge supports identity; it does not independently turn the primary candidate assignment into a purified-protein result."", ""source_locator"": ""/results/2/primaryAccession; /results/2/genes; /results/2/organism; /results/2/sequence; /results/2/uniProtKBCrossReferences""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Table 1 lists Tneu_1204 among the putative genes for cycle activity 2; direct activity is measured in cell extract."", ""source_locator"": ""PMC2698501 HTML //table[1] column Putative gene(s) in T. neutrophilus""}, {""reference_id"": ""UniProtKB:B1Y8Q3"", ""source_assertion"": ""The current unreviewed catalytic annotation cites RHEA:11364 with ECO:0000256 automated rule inference. It supports a qualified functional assignment, not direct experimental validation of this protein."", ""source_locator"": ""/results/2/comments/1/reaction""}]"	"[{""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""UniProtKB:B1Y8Q3"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 91, sequence version 1; digest covers whole batch"", ""title"": ""Phosphoenolpyruvate synthase"", ""url"": ""https://www.uniprot.org/uniprotkb/B1Y8Q3""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-083_6b2866dee3f9	UniProtKB:B1YBY2	pathwaymech:enables	RHEA:28372	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19411323|UniProtKB:B1YBY2	Functional assignment of Tneu_0418; Cell-extract direct activity; exact locus is a primary candidate/current HAMAP assignment. Mn2+ is present in assay, not automatically a demonstrated native occupancy requirement.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Tneu_0418 is the Table 1 candidate PEP carboxylase; activity is demonstrated in extract, not purified Tneu_0418."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[6]; (//table)[1] column Putative gene(s) in T. neutrophilus""}, {""reference_id"": ""UniProtKB:B1YBY2"", ""source_assertion"": ""This unreviewed entry identifies Tneu_0418 as UniProtKB:B1YBY2 in strain DSM 2338/V24Sta (taxon 444157). The locus/sequence bridge supports identity; it does not independently turn the primary candidate assignment into a purified-protein result."", ""source_locator"": ""/results/12/primaryAccession; /results/12/genes; /results/12/organism; /results/12/sequence; /results/12/uniProtKBCrossReferences""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Table 1 lists Tneu_0418 among the putative genes for cycle activity 3; direct activity is measured in cell extract."", ""source_locator"": ""PMC2698501 HTML //table[1] column Putative gene(s) in T. neutrophilus""}, {""reference_id"": ""UniProtKB:B1YBY2"", ""source_assertion"": ""The current unreviewed catalytic annotation cites RHEA:28370 with ECO:0000256 automated rule inference. It supports a qualified functional assignment, not direct experimental validation of this protein."", ""source_locator"": ""/results/12/comments/1/reaction""}, {""reference_id"": ""UniProtKB:B1YBY2"", ""source_assertion"": ""The current homotetramer annotation is HAMAP ECO:0000256 inference, not an assembly measurement in the primary extract assays."", ""source_locator"": ""/results/12/comments/3""}]"	"[{""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""UniProtKB:B1YBY2"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 74, sequence version 1; digest covers whole batch"", ""title"": ""Phosphoenolpyruvate carboxylase"", ""url"": ""https://www.uniprot.org/uniprotkb/B1YBY2""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-084_1204940cbfb8	UniProtKB:B1Y9K4	pathwaymech:enables	RHEA:21434	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19411323|UniProtKB:B1Y9K4	Functional assignment of Tneu_1509; NADH-dependent extract assay; use the NADH-specific reaction, not the preferred NADPH function of different I. hospitalis Mdh.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Tneu_1509 is the Table 1 candidate malate dehydrogenase; the NADH-dependent reaction is demonstrated in extract."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[8]; (//table)[1] column Putative gene(s) in T. neutrophilus""}, {""reference_id"": ""UniProtKB:B1Y9K4"", ""source_assertion"": ""This unreviewed entry identifies Tneu_1509 as UniProtKB:B1Y9K4 in strain DSM 2338/V24Sta (taxon 444157). The locus/sequence bridge supports identity; it does not independently turn the primary candidate assignment into a purified-protein result."", ""source_locator"": ""/results/9/primaryAccession; /results/9/genes; /results/9/organism; /results/9/sequence; /results/9/uniProtKBCrossReferences""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Table 1 lists Tneu_1509 among the putative genes for cycle activity 4; direct activity is measured in cell extract."", ""source_locator"": ""PMC2698501 HTML //table[1] column Putative gene(s) in T. neutrophilus""}]"	"[{""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""UniProtKB:B1Y9K4"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 96, sequence version 1; digest covers whole batch"", ""title"": ""Malate dehydrogenase"", ""url"": ""https://www.uniprot.org/uniprotkb/B1Y9K4""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-085_d297cf89a1b1	UniProtKB:B1Y931	pathwaymech:enables	RHEA:12461	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19411323|UniProtKB:B1Y931	Functional assignment of Tneu_1334; Cell-extract activity, candidate two-subunit locus. Current names are tartrate/fumarate-family proteins, including submitted EC4.2.1.32; no direct purified Tneu assembly or obligatory stoichiometry established.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Table 1 assigns Tneu_1334/1335 as putative fumarate-hydratase subunits. The direct activity is in extract; individual subunit sufficiency and exact assembly stoichiometry were not measured."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[9]; (//table)[1] column Putative gene(s) in T. neutrophilus""}, {""reference_id"": ""UniProtKB:B1Y931"", ""source_assertion"": ""This unreviewed entry identifies Tneu_1334 as UniProtKB:B1Y931 in strain DSM 2338/V24Sta (taxon 444157). The locus/sequence bridge supports identity; it does not independently turn the primary candidate assignment into a purified-protein result."", ""source_locator"": ""/results/14/primaryAccession; /results/14/genes; /results/14/organism; /results/14/sequence; /results/14/uniProtKBCrossReferences""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Table 1 lists Tneu_1334 among the putative genes for cycle activity 5; direct activity is measured in cell extract."", ""source_locator"": ""PMC2698501 HTML //table[1] column Putative gene(s) in T. neutrophilus""}]"	"[{""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""UniProtKB:B1Y931"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 66, sequence version 1; digest covers whole batch"", ""title"": ""Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit"", ""url"": ""https://www.uniprot.org/uniprotkb/B1Y931""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-086_953f66c9f64c	UniProtKB:B1Y932	pathwaymech:enables	RHEA:12461	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19411323|UniProtKB:B1Y932	Functional assignment of Tneu_1335; Cell-extract activity, candidate two-subunit locus. Current names are tartrate/fumarate-family proteins, including submitted EC4.2.1.32; no direct purified Tneu assembly or obligatory stoichiometry established.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Table 1 assigns Tneu_1334/1335 as putative fumarate-hydratase subunits. The direct activity is in extract; individual subunit sufficiency and exact assembly stoichiometry were not measured."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""sec5\""]/p[9]; (//table)[1] column Putative gene(s) in T. neutrophilus""}, {""reference_id"": ""UniProtKB:B1Y932"", ""source_assertion"": ""This unreviewed entry identifies Tneu_1335 as UniProtKB:B1Y932 in strain DSM 2338/V24Sta (taxon 444157). The locus/sequence bridge supports identity; it does not independently turn the primary candidate assignment into a purified-protein result."", ""source_locator"": ""/results/22/primaryAccession; /results/22/genes; /results/22/organism; /results/22/sequence; /results/22/uniProtKBCrossReferences""}, {""reference_id"": ""PMID:19411323"", ""source_assertion"": ""Table 1 lists Tneu_1335 among the putative genes for cycle activity 5; direct activity is measured in cell extract."", ""source_locator"": ""PMC2698501 HTML //table[1] column Putative gene(s) in T. neutrophilus""}]"	"[{""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""UniProtKB:B1Y932"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 66, sequence version 1; digest covers whole batch"", ""title"": ""Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit"", ""url"": ""https://www.uniprot.org/uniprotkb/B1Y932""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-087_3883a591552f	UniProtKB:B1YBY7	pathwaymech:enables	RHEA:16359	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21169482|UniProtKB:B1YBY7	Functional assignment of Tneu_0423; Reduced methyl viologen works in vitro; NAD(P)H does not. Soluble activity and putative induced subunits are supported. Disposition KEGG quinol equation R02164; use source-issued generic A/AH2 Rhea chemistry with an unknown physiological-donor qualification. No quinol or particular ferredoxin claim.	"[{""reference_id"": ""PMID:21169482"", ""source_assertion"": ""Tneu_0423/0424 are putative fumarate-reductase subunits induced during autotrophic growth. Soluble extract activity uses reduced viologens, not NAD(P)H; neither isolated subunit is asserted to catalyze the whole reaction."", ""source_locator"": ""PMC3067573 HTML //*[@id=\""sec27\""]/p[1]""}, {""reference_id"": ""UniProtKB:B1YBY7"", ""source_assertion"": ""This unreviewed entry identifies Tneu_0423 as UniProtKB:B1YBY7 in strain DSM 2338/V24Sta (taxon 444157). The locus/sequence bridge supports identity; it does not independently turn the primary candidate assignment into a purified-protein result."", ""source_locator"": ""/results/13/primaryAccession; /results/13/genes; /results/13/organism; /results/13/sequence; /results/13/uniProtKBCrossReferences""}]"	"[{""id"": ""PMID:21169482"", ""source_sha256"": ""0e10b7fd643550058542e4318f2d04fb8069d784f0d0d62c76aa2dada93f038e"", ""source_version"": ""2011 original article HTML; retrieved 2026-10-11"", ""title"": ""Identification of Missing Genes and Enzymes for Autotrophic Carbon Fixation in Crenarchaeota"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3067573/""}, {""id"": ""UniProtKB:B1YBY7"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 90, sequence version 1; digest covers whole batch"", ""title"": ""succinate dehydrogenase"", ""url"": ""https://www.uniprot.org/uniprotkb/B1YBY7""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-088_9ee9253e8ca5	UniProtKB:B1YBY8	pathwaymech:enables	RHEA:16359	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21169482|UniProtKB:B1YBY8	Functional assignment of Tneu_0424; Reduced methyl viologen works in vitro; NAD(P)H does not. Soluble activity and putative induced subunits are supported. Disposition KEGG quinol equation R02164; use source-issued generic A/AH2 Rhea chemistry with an unknown physiological-donor qualification. No quinol or particular ferredoxin claim.	"[{""reference_id"": ""PMID:21169482"", ""source_assertion"": ""Tneu_0423/0424 are putative fumarate-reductase subunits induced during autotrophic growth. Soluble extract activity uses reduced viologens, not NAD(P)H; neither isolated subunit is asserted to catalyze the whole reaction."", ""source_locator"": ""PMC3067573 HTML //*[@id=\""sec27\""]/p[1]""}, {""reference_id"": ""UniProtKB:B1YBY8"", ""source_assertion"": ""This unreviewed entry identifies Tneu_0424 as UniProtKB:B1YBY8 in strain DSM 2338/V24Sta (taxon 444157). The locus/sequence bridge supports identity; it does not independently turn the primary candidate assignment into a purified-protein result."", ""source_locator"": ""/results/18/primaryAccession; /results/18/genes; /results/18/organism; /results/18/sequence; /results/18/uniProtKBCrossReferences""}]"	"[{""id"": ""PMID:21169482"", ""source_sha256"": ""0e10b7fd643550058542e4318f2d04fb8069d784f0d0d62c76aa2dada93f038e"", ""source_version"": ""2011 original article HTML; retrieved 2026-10-11"", ""title"": ""Identification of Missing Genes and Enzymes for Autotrophic Carbon Fixation in Crenarchaeota"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3067573/""}, {""id"": ""UniProtKB:B1YBY8"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 83, sequence version 1; digest covers whole batch"", ""title"": ""Ferredoxin"", ""url"": ""https://www.uniprot.org/uniprotkb/B1YBY8""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-089_680931e7bb9a	UniProtKB:B1Y9F9	pathwaymech:enables	RHEA:17662	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21169482|UniProtKB:B1Y9F9	Functional assignment of Tneu_1463; Direct extract reaction with M. sedula coupling enzyme. Current HAMAP subunits are inferred; do not attribute the coupling enzyme or its NADPH to Tneu synthetase.	"[{""reference_id"": ""PMID:21169482"", ""source_assertion"": ""Tneu_1463 and Tneu_1464 are the two autotrophy-induced succinyl-CoA synthetase subunits. Their joint role does not establish that each independently catalyzes the reaction."", ""source_locator"": ""PMC3067573 HTML //*[@id=\""sec29\""]/p[1]""}, {""reference_id"": ""UniProtKB:B1Y9F9"", ""source_assertion"": ""This unreviewed entry identifies Tneu_1463 as UniProtKB:B1Y9F9 in strain DSM 2338/V24Sta (taxon 444157). The locus/sequence bridge supports identity; it does not independently turn the primary candidate assignment into a purified-protein result."", ""source_locator"": ""/results/0/primaryAccession; /results/0/genes; /results/0/organism; /results/0/sequence; /results/0/uniProtKBCrossReferences""}, {""reference_id"": ""UniProtKB:B1Y9F9"", ""source_assertion"": ""The current unreviewed catalytic annotation cites RHEA:17661 with ECO:0000256 automated rule inference. It supports a qualified functional assignment, not direct experimental validation of this protein."", ""source_locator"": ""/results/0/comments/2/reaction""}, {""reference_id"": ""UniProtKB:B1Y9F9"", ""source_assertion"": ""Current HAMAP/RuleBase annotation describes a heterotetramer with two alpha and two beta subunits. This is ECO:0000256 inference, not a demonstrated native Tneu assembly."", ""source_locator"": ""/results/0/comments/5""}]"	"[{""id"": ""PMID:21169482"", ""source_sha256"": ""0e10b7fd643550058542e4318f2d04fb8069d784f0d0d62c76aa2dada93f038e"", ""source_version"": ""2011 original article HTML; retrieved 2026-10-11"", ""title"": ""Identification of Missing Genes and Enzymes for Autotrophic Carbon Fixation in Crenarchaeota"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3067573/""}, {""id"": ""UniProtKB:B1Y9F9"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 94, sequence version 1; digest covers whole batch"", ""title"": ""Succinate--CoA ligase [ADP-forming] subunit beta"", ""url"": ""https://www.uniprot.org/uniprotkb/B1Y9F9""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-090_612c11521b8b	UniProtKB:B1Y9G0	pathwaymech:enables	RHEA:17662	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21169482|UniProtKB:B1Y9G0	Functional assignment of Tneu_1464; Direct extract reaction with M. sedula coupling enzyme. Current HAMAP subunits are inferred; do not attribute the coupling enzyme or its NADPH to Tneu synthetase.	"[{""reference_id"": ""PMID:21169482"", ""source_assertion"": ""Tneu_1463 and Tneu_1464 are the two autotrophy-induced succinyl-CoA synthetase subunits. Their joint role does not establish that each independently catalyzes the reaction."", ""source_locator"": ""PMC3067573 HTML //*[@id=\""sec29\""]/p[1]""}, {""reference_id"": ""UniProtKB:B1Y9G0"", ""source_assertion"": ""This unreviewed entry identifies Tneu_1464 as UniProtKB:B1Y9G0 in strain DSM 2338/V24Sta (taxon 444157). The locus/sequence bridge supports identity; it does not independently turn the primary candidate assignment into a purified-protein result."", ""source_locator"": ""/results/1/primaryAccession; /results/1/genes; /results/1/organism; /results/1/sequence; /results/1/uniProtKBCrossReferences""}, {""reference_id"": ""UniProtKB:B1Y9G0"", ""source_assertion"": ""The current unreviewed catalytic annotation cites RHEA:17661 with ECO:0000256 automated rule inference. It supports a qualified functional assignment, not direct experimental validation of this protein."", ""source_locator"": ""/results/1/comments/2/reaction""}, {""reference_id"": ""UniProtKB:B1Y9G0"", ""source_assertion"": ""Current HAMAP/RuleBase annotation describes a heterotetramer with two alpha and two beta subunits. This is ECO:0000256 inference, not a demonstrated native Tneu assembly."", ""source_locator"": ""/results/1/comments/4""}]"	"[{""id"": ""PMID:21169482"", ""source_sha256"": ""0e10b7fd643550058542e4318f2d04fb8069d784f0d0d62c76aa2dada93f038e"", ""source_version"": ""2011 original article HTML; retrieved 2026-10-11"", ""title"": ""Identification of Missing Genes and Enzymes for Autotrophic Carbon Fixation in Crenarchaeota"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3067573/""}, {""id"": ""UniProtKB:B1Y9G0"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 110, sequence version 1; digest covers whole batch"", ""title"": ""Succinate--CoA ligase [ADP-forming] subunit alpha"", ""url"": ""https://www.uniprot.org/uniprotkb/B1Y9G0""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-091_35fb5b36e55b	UniProtKB:B1YBY5	pathwaymech:enables	RHEA:26452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21169482|UniProtKB:B1YBY5	Functional assignment of Tneu_0421; Direct purified N-terminal His10-tagged Tneu_0421 expressed in E. coli. NADPH preferred, NADH10%; no malonyl-/methylmalonyl-CoA activity. Current homotetramer is ARBA inference, not the measured experiment. Exact I. hospitalis function/donor cannot be transferred.	"[{""reference_id"": ""PMID:21169482"", ""source_assertion"": ""Tneu_0421 was expressed in E. coli as soluble N-terminal His10-tagged protein and purified. It reduced succinyl-CoA with NADPH, with 10% activity using NADH; malonyl-CoA and methylmalonyl-CoA were inactive."", ""source_locator"": ""PMC3067573 HTML //*[@id=\""sec20\""]/p[1]""}, {""reference_id"": ""UniProtKB:B1YBY5"", ""source_assertion"": ""This unreviewed entry identifies Tneu_0421 as UniProtKB:B1YBY5 in strain DSM 2338/V24Sta (taxon 444157). The locus/sequence bridge supports identity; it does not independently turn the primary candidate assignment into a purified-protein result."", ""source_locator"": ""/results/27/primaryAccession; /results/27/genes; /results/27/organism; /results/27/sequence; /results/27/uniProtKBCrossReferences""}, {""reference_id"": ""UniProtKB:B1YBY5"", ""source_assertion"": ""The current homotetramer annotation is ARBA ECO:0000256 inference. The functional edge neither asserts a measured assembly nor a catalytically sufficient monomer."", ""source_locator"": ""/results/27/comments/0""}]"	"[{""id"": ""PMID:21169482"", ""source_sha256"": ""0e10b7fd643550058542e4318f2d04fb8069d784f0d0d62c76aa2dada93f038e"", ""source_version"": ""2011 original article HTML; retrieved 2026-10-11"", ""title"": ""Identification of Missing Genes and Enzymes for Autotrophic Carbon Fixation in Crenarchaeota"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3067573/""}, {""id"": ""UniProtKB:B1YBY5"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 92, sequence version 1; digest covers whole batch"", ""title"": ""Aldehyde Dehydrogenase"", ""url"": ""https://www.uniprot.org/uniprotkb/B1YBY5""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-092_e9019a890e31	UniProtKB:B1YBY3	pathwaymech:enables	RHEA:26383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21169482|UniProtKB:B1YBY3	Functional assignment of Tneu_0419; Direct purified N-terminal His10-tagged Tneu_0419. NADPH is supported; Zn2+ in current UniProt is ARBA/RuleBase inference, not direct primary metal analysis.	"[{""reference_id"": ""PMID:21169482"", ""source_assertion"": ""Tneu_0419 was expressed in E. coli as soluble N-terminal His10-tagged protein and purified. It catalyzed NADPH-dependent reduction of succinic semialdehyde."", ""source_locator"": ""PMC3067573 HTML //*[@id=\""sec21\""]/p[1]""}, {""reference_id"": ""UniProtKB:B1YBY3"", ""source_assertion"": ""This unreviewed entry identifies Tneu_0419 as UniProtKB:B1YBY3 in strain DSM 2338/V24Sta (taxon 444157). The locus/sequence bridge supports identity; it does not independently turn the primary candidate assignment into a purified-protein result."", ""source_locator"": ""/results/17/primaryAccession; /results/17/genes; /results/17/organism; /results/17/sequence; /results/17/uniProtKBCrossReferences""}]"	"[{""id"": ""PMID:21169482"", ""source_sha256"": ""0e10b7fd643550058542e4318f2d04fb8069d784f0d0d62c76aa2dada93f038e"", ""source_version"": ""2011 original article HTML; retrieved 2026-10-11"", ""title"": ""Identification of Missing Genes and Enzymes for Autotrophic Carbon Fixation in Crenarchaeota"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3067573/""}, {""id"": ""UniProtKB:B1YBY3"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 84, sequence version 1; digest covers whole batch"", ""title"": ""Alcohol dehydrogenase zinc-binding domain protein"", ""url"": ""https://www.uniprot.org/uniprotkb/B1YBY3""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-093_5a4248e63004	UniProtKB:B1YBY4	pathwaymech:enables	RHEA:23129	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21169482|UniProtKB:B1YBY4	Functional assignment of Tneu_0420; Purified recombinant protein acts on4HB; low activity linked to Lys594 acetylation in E. coli expression. Native archaeal regulation by acetylation is not established. This verified Tneu ligase must not inherit the failed I. hospitalis0256/0257 assignment.	"[{""reference_id"": ""PMID:21169482"", ""source_assertion"": ""Purified recombinant Tneu_0420 acted on 4-hydroxybutyrate. Lys594 acetylation was detected in the E. coli-produced protein and may be an expression artifact; native archaeal regulatory acetylation is not established."", ""source_locator"": ""PMC3067573 HTML //*[@id=\""sec22\""]/p[1]""}, {""reference_id"": ""UniProtKB:B1YBY4"", ""source_assertion"": ""This unreviewed entry identifies Tneu_0420 as UniProtKB:B1YBY4 in strain DSM 2338/V24Sta (taxon 444157). The locus/sequence bridge supports identity; it does not independently turn the primary candidate assignment into a purified-protein result."", ""source_locator"": ""/results/26/primaryAccession; /results/26/genes; /results/26/organism; /results/26/sequence; /results/26/uniProtKBCrossReferences""}]"	"[{""id"": ""PMID:21169482"", ""source_sha256"": ""0e10b7fd643550058542e4318f2d04fb8069d784f0d0d62c76aa2dada93f038e"", ""source_version"": ""2011 original article HTML; retrieved 2026-10-11"", ""title"": ""Identification of Missing Genes and Enzymes for Autotrophic Carbon Fixation in Crenarchaeota"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3067573/""}, {""id"": ""UniProtKB:B1YBY4"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 72, sequence version 1; digest covers whole batch"", ""title"": ""AMP-dependent synthetase and ligase"", ""url"": ""https://www.uniprot.org/uniprotkb/B1YBY4""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-094_295f1f321749	UniProtKB:B1YBY6	pathwaymech:enables	RHEA:26531	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21169482|UniProtKB:B1YBY6	Functional assignment of Tneu_0422; Direct extract conversion/coupled assay plus sequence-based Tneu_0422 attribution. No purified Tneu cofactor or assembly measurement in these sources; do not transfer clostridial Fe-S/FAD occupancy or oligomeric data as direct Tneu evidence.	"[{""reference_id"": ""PMID:21169482"", ""source_assertion"": ""Tneu_0422 is assigned by sequence similarity alongside extract dehydratase activity. Purified T. neutrophilus enzyme, assembly and Fe-S/FAD occupancy were not demonstrated in this study."", ""source_locator"": ""PMC3067573 HTML //*[@id=\""sec23\""]/p[1]""}, {""reference_id"": ""UniProtKB:B1YBY6"", ""source_assertion"": ""This unreviewed entry identifies Tneu_0422 as UniProtKB:B1YBY6 in strain DSM 2338/V24Sta (taxon 444157). The locus/sequence bridge supports identity; it does not independently turn the primary candidate assignment into a purified-protein result."", ""source_locator"": ""/results/20/primaryAccession; /results/20/genes; /results/20/organism; /results/20/sequence; /results/20/uniProtKBCrossReferences""}]"	"[{""id"": ""PMID:21169482"", ""source_sha256"": ""0e10b7fd643550058542e4318f2d04fb8069d784f0d0d62c76aa2dada93f038e"", ""source_version"": ""2011 original article HTML; retrieved 2026-10-11"", ""title"": ""Identification of Missing Genes and Enzymes for Autotrophic Carbon Fixation in Crenarchaeota"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3067573/""}, {""id"": ""UniProtKB:B1YBY6"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 77, sequence version 1; digest covers whole batch"", ""title"": ""Vinylacetyl-CoA Delta-isomerase"", ""url"": ""https://www.uniprot.org/uniprotkb/B1YBY6""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-095_4ac35afbb9ff	UniProtKB:B1YCH1	pathwaymech:enables	RHEA:26560	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21169482|UniProtKB:B1YCH1	Functional assignment of Tneu_0541; S-specific cell-extract activity is direct. The2011 purified bifunctional protein was Msed_0399; Tneu_0541 role is inferred from orthology/domain structure and unique candidate, not direct Tneu recombinant demonstration. Current monomer annotation is inferred.	"[{""reference_id"": ""PMID:21169482"", ""source_assertion"": ""Tneu_0541 is a candidate hydratase/dehydrogenase fusion identified by domain similarity. The purified native and recombinant enzyme tested in this section is Msed_0399, not Tneu_0541."", ""source_locator"": ""PMC3067573 HTML //*[@id=\""sec24\""]/p[1] for the candidate fusion; //*[@id=\""sec24\""]/p[2] for native and recombinant Msed_0399 characterization""}, {""reference_id"": ""UniProtKB:B1YCH1"", ""source_assertion"": ""This unreviewed entry identifies Tneu_0541 as UniProtKB:B1YCH1 in strain DSM 2338/V24Sta (taxon 444157). The locus/sequence bridge supports identity; it does not independently turn the primary candidate assignment into a purified-protein result."", ""source_locator"": ""/results/21/primaryAccession; /results/21/genes; /results/21/organism; /results/21/sequence; /results/21/uniProtKBCrossReferences""}, {""reference_id"": ""UniProtKB:B1YCH1"", ""source_assertion"": ""The current monomer annotation is ARBA ECO:0000256 inference; no experimental Tneu_0541 oligomeric state is claimed."", ""source_locator"": ""/results/21/comments/1""}]"	"[{""id"": ""PMID:21169482"", ""source_sha256"": ""0e10b7fd643550058542e4318f2d04fb8069d784f0d0d62c76aa2dada93f038e"", ""source_version"": ""2011 original article HTML; retrieved 2026-10-11"", ""title"": ""Identification of Missing Genes and Enzymes for Autotrophic Carbon Fixation in Crenarchaeota"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3067573/""}, {""id"": ""UniProtKB:B1YCH1"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 81, sequence version 1; digest covers whole batch"", ""title"": ""3-hydroxyacyl-CoA dehydrogenase NAD-binding"", ""url"": ""https://www.uniprot.org/uniprotkb/B1YCH1""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-096_e95ea86cf3f2	UniProtKB:B1YCH1	pathwaymech:enables	RHEA:30800	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21169482|UniProtKB:B1YCH1	Functional assignment of Tneu_0541; NAD+ and S substrate supported in Tneu extract; NADP+ and R stereoisomer inactive. Same exact Tneu fusion-protein assignment limit as step12; no direct Msed construct transfer.	"[{""reference_id"": ""PMID:21169482"", ""source_assertion"": ""The authors infer that the fusion protein operates in anaerobic crenarchaeal carbon fixation because it is the only candidate for these two activities; this is not a purified Tneu_0541 experiment."", ""source_locator"": ""PMC3067573 HTML //*[@id=\""sec24\""]/p[3]""}, {""reference_id"": ""UniProtKB:B1YCH1"", ""source_assertion"": ""This unreviewed entry identifies Tneu_0541 as UniProtKB:B1YCH1 in strain DSM 2338/V24Sta (taxon 444157). The locus/sequence bridge supports identity; it does not independently turn the primary candidate assignment into a purified-protein result."", ""source_locator"": ""/results/21/primaryAccession; /results/21/genes; /results/21/organism; /results/21/sequence; /results/21/uniProtKBCrossReferences""}, {""reference_id"": ""UniProtKB:B1YCH1"", ""source_assertion"": ""The current monomer annotation is ARBA ECO:0000256 inference; no experimental Tneu_0541 oligomeric state is claimed."", ""source_locator"": ""/results/21/comments/1""}]"	"[{""id"": ""PMID:21169482"", ""source_sha256"": ""0e10b7fd643550058542e4318f2d04fb8069d784f0d0d62c76aa2dada93f038e"", ""source_version"": ""2011 original article HTML; retrieved 2026-10-11"", ""title"": ""Identification of Missing Genes and Enzymes for Autotrophic Carbon Fixation in Crenarchaeota"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3067573/""}, {""id"": ""UniProtKB:B1YCH1"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 81, sequence version 1; digest covers whole batch"", ""title"": ""3-hydroxyacyl-CoA dehydrogenase NAD-binding"", ""url"": ""https://www.uniprot.org/uniprotkb/B1YCH1""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-097_984894c76838	UniProtKB:B1YB71	pathwaymech:enables	RHEA:21038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21169482|UniProtKB:B1YB71	Functional assignment of Tneu_0249; Direct soluble N-terminal His10-tagged Tneu_0249 expressed in E. coli, purified thiolytic cleavage. No arbitrary standalone monomer sufficiency/complex ID.	"[{""reference_id"": ""PMID:21169482"", ""source_assertion"": ""Tneu_0249 was expressed as soluble N-terminal His10-tagged protein in E. coli. The purified enzyme cleaved acetoacetyl-CoA thiolytically into two acetyl-CoA molecules."", ""source_locator"": ""PMC3067573 HTML //*[@id=\""sec25\""]/p[1]""}, {""reference_id"": ""UniProtKB:B1YB71"", ""source_assertion"": ""This unreviewed entry identifies Tneu_0249 as UniProtKB:B1YB71 in strain DSM 2338/V24Sta (taxon 444157). The locus/sequence bridge supports identity; it does not independently turn the primary candidate assignment into a purified-protein result."", ""source_locator"": ""/results/25/primaryAccession; /results/25/genes; /results/25/organism; /results/25/sequence; /results/25/uniProtKBCrossReferences""}]"	"[{""id"": ""PMID:21169482"", ""source_sha256"": ""0e10b7fd643550058542e4318f2d04fb8069d784f0d0d62c76aa2dada93f038e"", ""source_version"": ""2011 original article HTML; retrieved 2026-10-11"", ""title"": ""Identification of Missing Genes and Enzymes for Autotrophic Carbon Fixation in Crenarchaeota"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3067573/""}, {""id"": ""UniProtKB:B1YB71"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 83, sequence version 1; digest covers whole batch"", ""title"": ""Acetyl-CoA acetyltransferase"", ""url"": ""https://www.uniprot.org/uniprotkb/B1YB71""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-098_1880a397ebea	UniProtKB:B1Y8Q3	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:B1Y8Q3	Automated cofactor inference retained at its source tier; assay ingredients alone are not treated as a native requirement.	"[{""reference_id"": ""UniProtKB:B1Y8Q3"", ""source_assertion"": ""The current unreviewed record assigns CHEBI:18420 as a cofactor using ARBA/PIRNR ECO:0000256 inference. This is not direct metal/flavin occupancy measurement for purified T. neutrophilus protein."", ""source_locator"": ""/results/2/comments/2/cofactors""}]"	"[{""id"": ""UniProtKB:B1Y8Q3"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 91, sequence version 1; digest covers whole batch"", ""title"": ""Phosphoenolpyruvate synthase"", ""url"": ""https://www.uniprot.org/uniprotkb/B1Y8Q3""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-099_95ee6e36fef0	UniProtKB:B1YBY2	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:B1YBY2	Automated cofactor inference retained at its source tier; assay ingredients alone are not treated as a native requirement.	"[{""reference_id"": ""UniProtKB:B1YBY2"", ""source_assertion"": ""The current unreviewed record assigns CHEBI:18420 as a cofactor using HAMAP ECO:0000256 inference. This is not direct metal/flavin occupancy measurement for purified T. neutrophilus protein."", ""source_locator"": ""/results/12/comments/2/cofactors""}]"	"[{""id"": ""UniProtKB:B1YBY2"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 74, sequence version 1; digest covers whole batch"", ""title"": ""Phosphoenolpyruvate carboxylase"", ""url"": ""https://www.uniprot.org/uniprotkb/B1YBY2""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-100_6ebc0b6cc5a7	UniProtKB:B1Y9F9	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:B1Y9F9	Automated cofactor inference retained at its source tier; assay ingredients alone are not treated as a native requirement.	"[{""reference_id"": ""UniProtKB:B1Y9F9"", ""source_assertion"": ""The current unreviewed record assigns CHEBI:18420 as a cofactor using HAMAP ECO:0000256 inference. This is not direct metal/flavin occupancy measurement for purified T. neutrophilus protein."", ""source_locator"": ""/results/0/comments/3/cofactors""}]"	"[{""id"": ""UniProtKB:B1Y9F9"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 94, sequence version 1; digest covers whole batch"", ""title"": ""Succinate--CoA ligase [ADP-forming] subunit beta"", ""url"": ""https://www.uniprot.org/uniprotkb/B1Y9F9""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-101_004831270f38	UniProtKB:B1YBY7	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:B1YBY7	Automated cofactor inference retained at its source tier; assay ingredients alone are not treated as a native requirement.	"[{""reference_id"": ""UniProtKB:B1YBY7"", ""source_assertion"": ""The current unreviewed record assigns CHEBI:57692 as a cofactor using ARBA ECO:0000256 inference. This is not direct metal/flavin occupancy measurement for purified T. neutrophilus protein."", ""source_locator"": ""/results/13/comments/0/cofactors""}]"	"[{""id"": ""UniProtKB:B1YBY7"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 90, sequence version 1; digest covers whole batch"", ""title"": ""succinate dehydrogenase"", ""url"": ""https://www.uniprot.org/uniprotkb/B1YBY7""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-102_9ebaaf336939	UniProtKB:B1YBY3	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:B1YBY3	Automated cofactor inference retained at its source tier; assay ingredients alone are not treated as a native requirement.	"[{""reference_id"": ""UniProtKB:B1YBY3"", ""source_assertion"": ""The current unreviewed record assigns CHEBI:29105 as a cofactor using ARBA/RuleBase ECO:0000256 inference. This is not direct metal/flavin occupancy measurement for purified T. neutrophilus protein."", ""source_locator"": ""/results/17/comments/0/cofactors""}]"	"[{""id"": ""UniProtKB:B1YBY3"", ""source_sha256"": ""6e5a3cb33a618964bd4bd7bc576fbabd337a3958dff734099dbaba018bd914f7"", ""source_version"": ""Native 28-entry query retrieved 2026-10-11; entry version 84, sequence version 1; digest covers whole batch"", ""title"": ""Alcohol dehydrogenase zinc-binding domain protein"", ""url"": ""https://www.uniprot.org/uniprotkb/B1YBY3""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-103_77f96fb52aba	KEGG:R01196	RO:0002413	RHEA:11365	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15361|KEGG:C00024|KEGG:R01196|PMID:19411323|RHEA:11365	Material continuity through CHEBI:15361; physiological cycle context, not a new thermodynamic irreversibility claim.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""The Figure 1 cycle places activity 1 before activity 2 through the named carbon intermediate. The selected CHEBI:15361 microstate comes from the separately cited current reaction definitions, not from a primary ChEBI identifier."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""] caption and depicted cycle; Results //*[@id=\""sec18\""]""}, {""reference_id"": ""KEGG:R01196"", ""source_assertion"": ""Native R01196 connects acetyl-CoA C00024 and pyruvate C00022 using two generic ferredoxin redox partners and two H+ in its acid-form reference equation. Selected anion normalization is supported by separately cited compound and ChEBI bodies."", ""source_locator"": ""Original flatfile ENTRY R01196; DEFINITION; EQUATION; RCLASS C00022_C00024""}, {""reference_id"": ""RHEA:11365"", ""source_assertion"": ""Rhea directed reaction 11365 places CHEBI:15361 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/11365> rh:substrates <http://rdf.rhea-db.org/11364_L>; <http://rdf.rhea-db.org/11364_L> rh:contains1 <http://rdf.rhea-db.org/Participant_11364_compound_3719>; <http://rdf.rhea-db.org/Participant_11364_compound_3719> rh:compound <http://rdf.rhea-db.org/Compound_3719>; compound rh:accession""}, {""reference_id"": ""KEGG:C00024"", ""source_assertion"": ""The original compound batch gives C00024/C00010/C00022 formulas and ChEBI links to acetyl-CoA, CoA and pyruvic acid. These are native acid reference forms; this body alone does not define the selected deprotonated ChEBI forms."", ""source_locator"": ""Original five-entry batch ENTRY C00024/C00010/C00022; FORMULA; DBLINKS ChEBI:15351/15346/32816""}, {""reference_id"": ""CHEBI:15361"", ""source_assertion"": ""Original ChEBI forms differ only in protonation: 15351→57288 and 15346→57287 each lose four H; 32816→15361 loses one H. The CoA shifts cancel and product pyruvate deprotonation reduces native input two H+ to one. This is derived bookkeeping, not measured flux."", ""source_locator"": ""Original ChEBI255 semantic SQL statements for CHEBI:15351/57288, CHEBI:15346/57287, CHEBI:32816/15361; chemrof:generalized_empirical_formula, chemrof:charge, chemrof:inchi_string""}]"	"[{""id"": ""CHEBI:15361"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original uncompressed semantic SQL database, queried at the exact subjects in the source locator"", ""title"": ""pyruvate"", ""url"": ""https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15361""}, {""id"": ""KEGG:C00024"", ""source_sha256"": ""f535a194be2727c565e32e1ce24f6856ae497c068e20a4060005705d6248608f"", ""source_version"": ""Original five-entry batch retrieved 2026-10-11; digest covers entire batch"", ""title"": ""KEGG native small-molecule forms for R01196"", ""url"": ""https://rest.kegg.jp/get/C00024+C00011+C00022+C00010+C00080""}, {""id"": ""KEGG:R01196"", ""source_sha256"": ""d98a5c7a727196576fa268d700d196190e17f8218d257e9b74fcec1fd67e26b6"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:45:41.128609+00:00; original response has no per-entry release designation"", ""title"": ""pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)"", ""url"": ""https://rest.kegg.jp/get/R01196""}, {""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:11365"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""pyruvate + ATP + H2O => phosphoenolpyruvate + AMP + phosphate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/11365""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-104_0c6a62b3a3e0	RHEA:11365	RO:0002413	RHEA:28372	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19411323|RHEA:11365|RHEA:28372	Material continuity through CHEBI:58702; physiological cycle context, not a new thermodynamic irreversibility claim.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""The Figure 1 cycle places activity 2 before activity 3 through the named carbon intermediate. The selected CHEBI:58702 microstate comes from the separately cited current reaction definitions, not from a primary ChEBI identifier."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""] caption and depicted cycle; Results //*[@id=\""sec18\""]""}, {""reference_id"": ""RHEA:11365"", ""source_assertion"": ""Rhea directed reaction 11365 places CHEBI:58702 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/11365> rh:products <http://rdf.rhea-db.org/11364_R>; <http://rdf.rhea-db.org/11364_R> rh:contains1 <http://rdf.rhea-db.org/Participant_11364_compound_3582>; <http://rdf.rhea-db.org/Participant_11364_compound_3582> rh:compound <http://rdf.rhea-db.org/Compound_3582>; compound rh:accession""}, {""reference_id"": ""RHEA:28372"", ""source_assertion"": ""Rhea directed reaction 28372 places CHEBI:58702 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/28372> rh:substrates <http://rdf.rhea-db.org/28370_R>; <http://rdf.rhea-db.org/28370_R> rh:contains1 <http://rdf.rhea-db.org/Participant_28370_compound_3582>; <http://rdf.rhea-db.org/Participant_28370_compound_3582> rh:compound <http://rdf.rhea-db.org/Compound_3582>; compound rh:accession""}]"	"[{""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:11365"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""pyruvate + ATP + H2O => phosphoenolpyruvate + AMP + phosphate + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/11365""}, {""id"": ""RHEA:28372"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""phosphoenolpyruvate + hydrogencarbonate => oxaloacetate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/28372""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-105_4a4a290e6b12	RHEA:28372	RO:0002413	RHEA:21434	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19411323|RHEA:21434|RHEA:28372	Material continuity through CHEBI:16452; physiological cycle context, not a new thermodynamic irreversibility claim.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""The Figure 1 cycle places activity 3 before activity 4 through the named carbon intermediate. The selected CHEBI:16452 microstate comes from the separately cited current reaction definitions, not from a primary ChEBI identifier."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""] caption and depicted cycle; Results //*[@id=\""sec18\""]""}, {""reference_id"": ""RHEA:28372"", ""source_assertion"": ""Rhea directed reaction 28372 places CHEBI:16452 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/28372> rh:products <http://rdf.rhea-db.org/28370_L>; <http://rdf.rhea-db.org/28370_L> rh:contains1 <http://rdf.rhea-db.org/Participant_28370_compound_5219>; <http://rdf.rhea-db.org/Participant_28370_compound_5219> rh:compound <http://rdf.rhea-db.org/Compound_5219>; compound rh:accession""}, {""reference_id"": ""RHEA:21434"", ""source_assertion"": ""Rhea directed reaction 21434 places CHEBI:16452 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/21434> rh:substrates <http://rdf.rhea-db.org/21432_R>; <http://rdf.rhea-db.org/21432_R> rh:contains1 <http://rdf.rhea-db.org/Participant_21432_compound_5219>; <http://rdf.rhea-db.org/Participant_21432_compound_5219> rh:compound <http://rdf.rhea-db.org/Compound_5219>; compound rh:accession""}]"	"[{""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:21434"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""oxaloacetate + NADH + H(+) => (S)-malate + NAD(+)"", ""url"": ""https://www.rhea-db.org/rhea/21434""}, {""id"": ""RHEA:28372"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""phosphoenolpyruvate + hydrogencarbonate => oxaloacetate + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/28372""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-106_b4496665f958	RHEA:21434	RO:0002413	RHEA:12461	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19411323|RHEA:12461|RHEA:21434	Material continuity through CHEBI:15589; physiological cycle context, not a new thermodynamic irreversibility claim.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""The Figure 1 cycle places activity 4 before activity 5 through the named carbon intermediate. The selected CHEBI:15589 microstate comes from the separately cited current reaction definitions, not from a primary ChEBI identifier."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""] caption and depicted cycle; Results //*[@id=\""sec18\""]""}, {""reference_id"": ""RHEA:21434"", ""source_assertion"": ""Rhea directed reaction 21434 places CHEBI:15589 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/21434> rh:products <http://rdf.rhea-db.org/21432_L>; <http://rdf.rhea-db.org/21432_L> rh:contains1 <http://rdf.rhea-db.org/Participant_21432_compound_3953>; <http://rdf.rhea-db.org/Participant_21432_compound_3953> rh:compound <http://rdf.rhea-db.org/Compound_3953>; compound rh:accession""}, {""reference_id"": ""RHEA:12461"", ""source_assertion"": ""Rhea directed reaction 12461 places CHEBI:15589 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/12461> rh:substrates <http://rdf.rhea-db.org/12460_L>; <http://rdf.rhea-db.org/12460_L> rh:contains1 <http://rdf.rhea-db.org/Participant_12460_compound_3953>; <http://rdf.rhea-db.org/Participant_12460_compound_3953> rh:compound <http://rdf.rhea-db.org/Compound_3953>; compound rh:accession""}]"	"[{""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:12461"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(S)-malate => fumarate + H2O"", ""url"": ""https://www.rhea-db.org/rhea/12461""}, {""id"": ""RHEA:21434"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""oxaloacetate + NADH + H(+) => (S)-malate + NAD(+)"", ""url"": ""https://www.rhea-db.org/rhea/21434""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-107_ece83aedde3d	RHEA:12461	RO:0002413	RHEA:16359	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19411323|RHEA:12461|RHEA:16359	Material continuity through CHEBI:29806; physiological cycle context, not a new thermodynamic irreversibility claim.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""The Figure 1 cycle places activity 5 before activity 6 through the named carbon intermediate. The selected CHEBI:29806 microstate comes from the separately cited current reaction definitions, not from a primary ChEBI identifier."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""] caption and depicted cycle; Results //*[@id=\""sec18\""]""}, {""reference_id"": ""RHEA:12461"", ""source_assertion"": ""Rhea directed reaction 12461 places CHEBI:29806 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/12461> rh:products <http://rdf.rhea-db.org/12460_R>; <http://rdf.rhea-db.org/12460_R> rh:contains1 <http://rdf.rhea-db.org/Participant_12460_compound_3031>; <http://rdf.rhea-db.org/Participant_12460_compound_3031> rh:compound <http://rdf.rhea-db.org/Compound_3031>; compound rh:accession""}, {""reference_id"": ""RHEA:16359"", ""source_assertion"": ""Rhea directed reaction 16359 places CHEBI:29806 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/16359> rh:substrates <http://rdf.rhea-db.org/16357_R>; <http://rdf.rhea-db.org/16357_R> rh:contains1 <http://rdf.rhea-db.org/Participant_16357_compound_3031>; <http://rdf.rhea-db.org/Participant_16357_compound_3031> rh:compound <http://rdf.rhea-db.org/Compound_3031>; compound rh:accession""}]"	"[{""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:12461"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(S)-malate => fumarate + H2O"", ""url"": ""https://www.rhea-db.org/rhea/12461""}, {""id"": ""RHEA:16359"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""fumarate + AH2 => succinate + A"", ""url"": ""https://www.rhea-db.org/rhea/16359""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-108_401d1e52be1f	RHEA:16359	RO:0002413	RHEA:17662	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19411323|RHEA:16359|RHEA:17662	Material continuity through CHEBI:30031; physiological cycle context, not a new thermodynamic irreversibility claim.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""The Figure 1 cycle places activity 6 before activity 7 through the named carbon intermediate. The selected CHEBI:30031 microstate comes from the separately cited current reaction definitions, not from a primary ChEBI identifier."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""] caption and depicted cycle; Results //*[@id=\""sec18\""]""}, {""reference_id"": ""RHEA:16359"", ""source_assertion"": ""Rhea directed reaction 16359 places CHEBI:30031 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/16359> rh:products <http://rdf.rhea-db.org/16357_L>; <http://rdf.rhea-db.org/16357_L> rh:contains1 <http://rdf.rhea-db.org/Participant_16357_compound_2501>; <http://rdf.rhea-db.org/Participant_16357_compound_2501> rh:compound <http://rdf.rhea-db.org/Compound_2501>; compound rh:accession""}, {""reference_id"": ""RHEA:17662"", ""source_assertion"": ""Rhea directed reaction 17662 places CHEBI:30031 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/17662> rh:substrates <http://rdf.rhea-db.org/17661_L>; <http://rdf.rhea-db.org/17661_L> rh:contains1 <http://rdf.rhea-db.org/Participant_17661_compound_2501>; <http://rdf.rhea-db.org/Participant_17661_compound_2501> rh:compound <http://rdf.rhea-db.org/Compound_2501>; compound rh:accession""}]"	"[{""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:16359"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""fumarate + AH2 => succinate + A"", ""url"": ""https://www.rhea-db.org/rhea/16359""}, {""id"": ""RHEA:17662"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinate + ATP + CoA => succinyl-CoA + ADP + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/17662""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-109_13e07fe541a9	RHEA:17662	RO:0002413	RHEA:26452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19411323|RHEA:17662|RHEA:26452	Material continuity through CHEBI:57292; physiological cycle context, not a new thermodynamic irreversibility claim.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""The Figure 1 cycle places activity 7 before activity 8 through the named carbon intermediate. The selected CHEBI:57292 microstate comes from the separately cited current reaction definitions, not from a primary ChEBI identifier."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""] caption and depicted cycle; Results //*[@id=\""sec18\""]""}, {""reference_id"": ""RHEA:17662"", ""source_assertion"": ""Rhea directed reaction 17662 places CHEBI:57292 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/17662> rh:products <http://rdf.rhea-db.org/17661_R>; <http://rdf.rhea-db.org/17661_R> rh:contains1 <http://rdf.rhea-db.org/Participant_17661_compound_4684>; <http://rdf.rhea-db.org/Participant_17661_compound_4684> rh:compound <http://rdf.rhea-db.org/Compound_4684>; compound rh:accession""}, {""reference_id"": ""RHEA:26452"", ""source_assertion"": ""Rhea directed reaction 26452 places CHEBI:57292 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26452> rh:substrates <http://rdf.rhea-db.org/26450_R>; <http://rdf.rhea-db.org/26450_R> rh:contains1 <http://rdf.rhea-db.org/Participant_26450_compound_4684>; <http://rdf.rhea-db.org/Participant_26450_compound_4684> rh:compound <http://rdf.rhea-db.org/Compound_4684>; compound rh:accession""}]"	"[{""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:17662"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinate + ATP + CoA => succinyl-CoA + ADP + phosphate"", ""url"": ""https://www.rhea-db.org/rhea/17662""}, {""id"": ""RHEA:26452"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinyl-CoA + NADPH + H(+) => succinate semialdehyde + NADP(+) + CoA"", ""url"": ""https://www.rhea-db.org/rhea/26452""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-110_cc0b07509988	RHEA:26452	RO:0002413	RHEA:26383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19411323|RHEA:26383|RHEA:26452	Material continuity through CHEBI:57706; physiological cycle context, not a new thermodynamic irreversibility claim.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""The Figure 1 cycle places activity 8 before activity 9 through the named carbon intermediate. The selected CHEBI:57706 microstate comes from the separately cited current reaction definitions, not from a primary ChEBI identifier."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""] caption and depicted cycle; Results //*[@id=\""sec18\""]""}, {""reference_id"": ""RHEA:26452"", ""source_assertion"": ""Rhea directed reaction 26452 places CHEBI:57706 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26452> rh:products <http://rdf.rhea-db.org/26450_L>; <http://rdf.rhea-db.org/26450_L> rh:contains1 <http://rdf.rhea-db.org/Participant_26450_compound_4279>; <http://rdf.rhea-db.org/Participant_26450_compound_4279> rh:compound <http://rdf.rhea-db.org/Compound_4279>; compound rh:accession""}, {""reference_id"": ""RHEA:26383"", ""source_assertion"": ""Rhea directed reaction 26383 places CHEBI:57706 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26383> rh:substrates <http://rdf.rhea-db.org/26381_R>; <http://rdf.rhea-db.org/26381_R> rh:contains1 <http://rdf.rhea-db.org/Participant_26381_compound_4279>; <http://rdf.rhea-db.org/Participant_26381_compound_4279> rh:compound <http://rdf.rhea-db.org/Compound_4279>; compound rh:accession""}]"	"[{""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:26383"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinate semialdehyde + NADPH + H(+) => 4-hydroxybutanoate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/26383""}, {""id"": ""RHEA:26452"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinyl-CoA + NADPH + H(+) => succinate semialdehyde + NADP(+) + CoA"", ""url"": ""https://www.rhea-db.org/rhea/26452""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-111_47d959b3603e	RHEA:26383	RO:0002413	RHEA:23129	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19411323|RHEA:23129|RHEA:26383	Material continuity through CHEBI:16724; physiological cycle context, not a new thermodynamic irreversibility claim.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""The Figure 1 cycle places activity 9 before activity 10 through the named carbon intermediate. The selected CHEBI:16724 microstate comes from the separately cited current reaction definitions, not from a primary ChEBI identifier."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""] caption and depicted cycle; Results //*[@id=\""sec18\""]""}, {""reference_id"": ""RHEA:26383"", ""source_assertion"": ""Rhea directed reaction 26383 places CHEBI:16724 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26383> rh:products <http://rdf.rhea-db.org/26381_L>; <http://rdf.rhea-db.org/26381_L> rh:contains1 <http://rdf.rhea-db.org/Participant_26381_compound_5278>; <http://rdf.rhea-db.org/Participant_26381_compound_5278> rh:compound <http://rdf.rhea-db.org/Compound_5278>; compound rh:accession""}, {""reference_id"": ""RHEA:23129"", ""source_assertion"": ""Rhea directed reaction 23129 places CHEBI:16724 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/23129> rh:substrates <http://rdf.rhea-db.org/23128_L>; <http://rdf.rhea-db.org/23128_L> rh:contains1 <http://rdf.rhea-db.org/Participant_23128_compound_5278>; <http://rdf.rhea-db.org/Participant_23128_compound_5278> rh:compound <http://rdf.rhea-db.org/Compound_5278>; compound rh:accession""}]"	"[{""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:23129"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + AMP + diphosphate"", ""url"": ""https://www.rhea-db.org/rhea/23129""}, {""id"": ""RHEA:26383"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""succinate semialdehyde + NADPH + H(+) => 4-hydroxybutanoate + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/26383""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-112_d3d52555c551	RHEA:23129	RO:0002413	RHEA:26531	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19411323|RHEA:23129|RHEA:26531	Material continuity through CHEBI:58574; physiological cycle context, not a new thermodynamic irreversibility claim.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""The Figure 1 cycle places activity 10 before activity 11 through the named carbon intermediate. The selected CHEBI:58574 microstate comes from the separately cited current reaction definitions, not from a primary ChEBI identifier."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""] caption and depicted cycle; Results //*[@id=\""sec18\""]""}, {""reference_id"": ""RHEA:23129"", ""source_assertion"": ""Rhea directed reaction 23129 places CHEBI:58574 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/23129> rh:products <http://rdf.rhea-db.org/23128_R>; <http://rdf.rhea-db.org/23128_R> rh:contains1 <http://rdf.rhea-db.org/Participant_23128_compound_6032>; <http://rdf.rhea-db.org/Participant_23128_compound_6032> rh:compound <http://rdf.rhea-db.org/Compound_6032>; compound rh:accession""}, {""reference_id"": ""RHEA:26531"", ""source_assertion"": ""Rhea directed reaction 26531 places CHEBI:58574 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26531> rh:substrates <http://rdf.rhea-db.org/26530_L>; <http://rdf.rhea-db.org/26530_L> rh:contains1 <http://rdf.rhea-db.org/Participant_26530_compound_6032>; <http://rdf.rhea-db.org/Participant_26530_compound_6032> rh:compound <http://rdf.rhea-db.org/Compound_6032>; compound rh:accession""}]"	"[{""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:23129"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + AMP + diphosphate"", ""url"": ""https://www.rhea-db.org/rhea/23129""}, {""id"": ""RHEA:26531"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""4-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"", ""url"": ""https://www.rhea-db.org/rhea/26531""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-113_64dcc072036e	RHEA:26531	RO:0002413	RHEA:26560	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19411323|RHEA:26531|RHEA:26560	Material continuity through CHEBI:57332; physiological cycle context, not a new thermodynamic irreversibility claim.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""The Figure 1 cycle places activity 11 before activity 12 through the named carbon intermediate. The selected CHEBI:57332 microstate comes from the separately cited current reaction definitions, not from a primary ChEBI identifier."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""] caption and depicted cycle; Results //*[@id=\""sec18\""]""}, {""reference_id"": ""RHEA:26531"", ""source_assertion"": ""Rhea directed reaction 26531 places CHEBI:57332 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26531> rh:products <http://rdf.rhea-db.org/26530_R>; <http://rdf.rhea-db.org/26530_R> rh:contains1 <http://rdf.rhea-db.org/Participant_26530_compound_2633>; <http://rdf.rhea-db.org/Participant_26530_compound_2633> rh:compound <http://rdf.rhea-db.org/Compound_2633>; compound rh:accession""}, {""reference_id"": ""RHEA:26560"", ""source_assertion"": ""Rhea directed reaction 26560 places CHEBI:57332 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26560> rh:substrates <http://rdf.rhea-db.org/26558_R>; <http://rdf.rhea-db.org/26558_R> rh:contains1 <http://rdf.rhea-db.org/Participant_26558_compound_2633>; <http://rdf.rhea-db.org/Participant_26558_compound_2633> rh:compound <http://rdf.rhea-db.org/Compound_2633>; compound rh:accession""}]"	"[{""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:26531"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""4-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"", ""url"": ""https://www.rhea-db.org/rhea/26531""}, {""id"": ""RHEA:26560"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(2E)-butenoyl-CoA + H2O => (3S)-3-hydroxybutanoyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/26560""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-114_de811c81c11d	RHEA:26560	RO:0002413	RHEA:30800	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19411323|RHEA:26560|RHEA:30800	Material continuity through CHEBI:57316; physiological cycle context, not a new thermodynamic irreversibility claim.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""The Figure 1 cycle places activity 12 before activity 13 through the named carbon intermediate. The selected CHEBI:57316 microstate comes from the separately cited current reaction definitions, not from a primary ChEBI identifier."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""] caption and depicted cycle; Results //*[@id=\""sec18\""]""}, {""reference_id"": ""RHEA:26560"", ""source_assertion"": ""Rhea directed reaction 26560 places CHEBI:57316 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/26560> rh:products <http://rdf.rhea-db.org/26558_L>; <http://rdf.rhea-db.org/26558_L> rh:contains1 <http://rdf.rhea-db.org/Participant_26558_compound_2192>; <http://rdf.rhea-db.org/Participant_26558_compound_2192> rh:compound <http://rdf.rhea-db.org/Compound_2192>; compound rh:accession""}, {""reference_id"": ""RHEA:30800"", ""source_assertion"": ""Rhea directed reaction 30800 places CHEBI:57316 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/30800> rh:substrates <http://rdf.rhea-db.org/30799_L>; <http://rdf.rhea-db.org/30799_L> rh:contains1 <http://rdf.rhea-db.org/Participant_30799_compound_2192>; <http://rdf.rhea-db.org/Participant_30799_compound_2192> rh:compound <http://rdf.rhea-db.org/Compound_2192>; compound rh:accession""}]"	"[{""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:26560"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(2E)-butenoyl-CoA + H2O => (3S)-3-hydroxybutanoyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/26560""}, {""id"": ""RHEA:30800"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(3S)-3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + NADH + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/30800""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-115_2627f4086473	RHEA:30800	RO:0002413	RHEA:21038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19411323|RHEA:21038|RHEA:30800	Material continuity through CHEBI:57286; physiological cycle context, not a new thermodynamic irreversibility claim.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""The Figure 1 cycle places activity 13 before activity 14 through the named carbon intermediate. The selected CHEBI:57286 microstate comes from the separately cited current reaction definitions, not from a primary ChEBI identifier."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""] caption and depicted cycle; Results //*[@id=\""sec18\""]""}, {""reference_id"": ""RHEA:30800"", ""source_assertion"": ""Rhea directed reaction 30800 places CHEBI:57286 on its products side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/30800> rh:products <http://rdf.rhea-db.org/30799_R>; <http://rdf.rhea-db.org/30799_R> rh:contains1 <http://rdf.rhea-db.org/Participant_30799_compound_4872>; <http://rdf.rhea-db.org/Participant_30799_compound_4872> rh:compound <http://rdf.rhea-db.org/Compound_4872>; compound rh:accession""}, {""reference_id"": ""RHEA:21038"", ""source_assertion"": ""Rhea directed reaction 21038 places CHEBI:57286 on its substrates side with coefficient 1."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/21038> rh:substrates <http://rdf.rhea-db.org/21036_R>; <http://rdf.rhea-db.org/21036_R> rh:contains1 <http://rdf.rhea-db.org/Participant_21036_compound_4872>; <http://rdf.rhea-db.org/Participant_21036_compound_4872> rh:compound <http://rdf.rhea-db.org/Compound_4872>; compound rh:accession""}]"	"[{""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:21038"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""acetoacetyl-CoA + CoA => 2 acetyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/21038""}, {""id"": ""RHEA:30800"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""(3S)-3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + NADH + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/30800""}]"	""
pathwaymech:KEGG_M00374_dchb-edge-116_ac19388333ab	RHEA:21038	RO:0002413	KEGG:R01196	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:57288|KEGG:C00024|KEGG:R01196|PMID:19411323|RHEA:21038	Material continuity through CHEBI:57288; physiological cycle context, not a new thermodynamic irreversibility claim.	"[{""reference_id"": ""PMID:19411323"", ""source_assertion"": ""The Figure 1 cycle places activity 14 before activity 1 through the named carbon intermediate. The selected CHEBI:57288 microstate comes from the separately cited current reaction definitions, not from a primary ChEBI identifier."", ""source_locator"": ""PMC2698501 HTML //*[@id=\""f1\""] caption and depicted cycle; Results //*[@id=\""sec18\""]""}, {""reference_id"": ""RHEA:21038"", ""source_assertion"": ""Rhea directed reaction 21038 places CHEBI:57288 on its products side with coefficient 2."", ""source_locator"": ""RDF142 <http://rdf.rhea-db.org/21038> rh:products <http://rdf.rhea-db.org/21036_L>; <http://rdf.rhea-db.org/21036_L> rh:contains2 <http://rdf.rhea-db.org/Participant_21036_compound_4271>; <http://rdf.rhea-db.org/Participant_21036_compound_4271> rh:compound <http://rdf.rhea-db.org/Compound_4271>; compound rh:accession""}, {""reference_id"": ""KEGG:R01196"", ""source_assertion"": ""Native R01196 connects acetyl-CoA C00024 and pyruvate C00022 using two generic ferredoxin redox partners and two H+ in its acid-form reference equation. Selected anion normalization is supported by separately cited compound and ChEBI bodies."", ""source_locator"": ""Original flatfile ENTRY R01196; DEFINITION; EQUATION; RCLASS C00022_C00024""}, {""reference_id"": ""KEGG:C00024"", ""source_assertion"": ""The original compound batch gives C00024/C00010/C00022 formulas and ChEBI links to acetyl-CoA, CoA and pyruvic acid. These are native acid reference forms; this body alone does not define the selected deprotonated ChEBI forms."", ""source_locator"": ""Original five-entry batch ENTRY C00024/C00010/C00022; FORMULA; DBLINKS ChEBI:15351/15346/32816""}, {""reference_id"": ""CHEBI:57288"", ""source_assertion"": ""Original ChEBI forms differ only in protonation: 15351→57288 and 15346→57287 each lose four H; 32816→15361 loses one H. The CoA shifts cancel and product pyruvate deprotonation reduces native input two H+ to one. This is derived bookkeeping, not measured flux."", ""source_locator"": ""Original ChEBI255 semantic SQL statements for CHEBI:15351/57288, CHEBI:15346/57287, CHEBI:32816/15361; chemrof:generalized_empirical_formula, chemrof:charge, chemrof:inchi_string""}]"	"[{""id"": ""CHEBI:57288"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original uncompressed semantic SQL database, queried at the exact subjects in the source locator"", ""title"": ""acetyl-CoA(4-)"", ""url"": ""https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:57288""}, {""id"": ""KEGG:C00024"", ""source_sha256"": ""f535a194be2727c565e32e1ce24f6856ae497c068e20a4060005705d6248608f"", ""source_version"": ""Original five-entry batch retrieved 2026-10-11; digest covers entire batch"", ""title"": ""KEGG native small-molecule forms for R01196"", ""url"": ""https://rest.kegg.jp/get/C00024+C00011+C00022+C00010+C00080""}, {""id"": ""KEGG:R01196"", ""source_sha256"": ""d98a5c7a727196576fa268d700d196190e17f8218d257e9b74fcec1fd67e26b6"", ""source_version"": ""Entry snapshot retrieved 2026-10-11T10:45:41.128609+00:00; original response has no per-entry release designation"", ""title"": ""pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)"", ""url"": ""https://rest.kegg.jp/get/R01196""}, {""id"": ""PMID:19411323"", ""source_sha256"": ""7bdd2892c2b43ca591cba18c7757b54beafe2e98634223d518c381e35d09769a"", ""source_version"": ""2009 original article HTML; retrieved 2026-10-11"", ""title"": ""Autotrophic Carbon Dioxide Assimilation in Thermoproteales Revisited"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2698501/""}, {""id"": ""RHEA:21038"", ""source_version"": ""Rhea release 142; original RDF and official direction table retained; full-body hashes in manifest"", ""title"": ""acetoacetyl-CoA + CoA => 2 acetyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/21038""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-001_a4090557f827	gomodel:2.4.1.117-RXN	RO:0002233	CHEBI:58885	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:2.4.1.117-RXN RO:0002233 gomodel:CHEBI_58885_GLUC1PURIDYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/0; endpoint types: /individuals/32/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-002_f3e9fe5c9d74	gomodel:YeastPathways_PWY3O-1565/6a4c244800003247	RO:0002233	CHEBI:4170	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003247 RO:0002233 gomodel:YeastPathways_PWY3O-1565/6a4c244800003248."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/1; endpoint types: /individuals/36/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-003_6977c8710b8b	gomodel:YeastPathways_PWY3O-1565/6a4c244800003258	RO:0002233	CHEBI:46398	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003258 RO:0002233 gomodel:YeastPathways_PWY3O-1565/6a4c244800003260."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/2; endpoint types: /individuals/46/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-004_a19609cd572c	gomodel:GLUC1PURIDYLTRANS-RXN	BFO:0000050	GO:0016051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:GLUC1PURIDYLTRANS-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-1565/YeastPathways_PWY3O-1565."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/3; endpoint types: /individuals/9/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-005_018e62ac4fc0	gomodel:PHOSPHOGLUCMUT-RXN	BFO:0000050	GO:0016051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOGLUCMUT-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-1565/YeastPathways_PWY3O-1565."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/4; endpoint types: /individuals/10/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-006_b16e0e8d8cd7	gomodel:PHOSPHOGLUCMUT-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-1565/6a4c244800003258	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOGLUCMUT-RXN RO:0002413 gomodel:YeastPathways_PWY3O-1565/6a4c244800003258."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/5; endpoint types: /individuals/10/type; /individuals/46/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-007_0e44ab6486bf	gomodel:YeastPathways_PWY3O-1565/6a4c244800003258	RO:0002234	CHEBI:58885	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003258 RO:0002234 gomodel:CHEBI_58885_GLUC1PURIDYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/6; endpoint types: /individuals/46/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-008_a1b33d34cb18	gomodel:GLUC1PURIDYLTRANS-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:GLUC1PURIDYLTRANS-RXN RO:0002233 gomodel:CHEBI_15378_GLUC1PURIDYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/7; endpoint types: /individuals/9/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-009_82d34f6675b3	gomodel:2.4.1.117-RXN	RO:0002234	CHEBI:58223	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:2.4.1.117-RXN RO:0002234 gomodel:CHEBI_58223_2.4.1.117-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/8; endpoint types: /individuals/32/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-010_697becaa537f	gomodel:GLUC1PURIDYLTRANS-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:GLUC1PURIDYLTRANS-RXN RO:0002234 gomodel:CHEBI_29888_GLUC1PURIDYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/9; endpoint types: /individuals/9/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-011_3784db035a5b	gomodel:PHOSPHOGLUCMUT-RXN	RO:0002413	gomodel:GLUC1PURIDYLTRANS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOGLUCMUT-RXN RO:0002413 gomodel:GLUC1PURIDYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/10; endpoint types: /individuals/10/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-012_c937c29c1d4b	gomodel:YeastPathways_PWY3O-1565/6a4c244800003247	RO:0002413	gomodel:YeastPathways_PWY3O-1565/6a4c244800003258	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003247 RO:0002413 gomodel:YeastPathways_PWY3O-1565/6a4c244800003258."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/11; endpoint types: /individuals/36/type; /individuals/46/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-013_3cdd95636279	SGD:S000006148	pathwaymech:enables	gomodel:2.4.1.117-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:2.4.1.117-RXN RO:0002333 gomodel:YPL227C-MONOMER_2.4.1.117-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/12; endpoint types: /individuals/32/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-014_7cff60c007ce	gomodel:GLUC1PURIDYLTRANS-RXN	RO:0002233	CHEBI:46398	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:GLUC1PURIDYLTRANS-RXN RO:0002233 gomodel:CHEBI_46398_GLUC1PURIDYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/13; endpoint types: /individuals/9/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-015_a3ecc8398a50	gomodel:YeastPathways_PWY3O-1565/6a4c244800003258	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003258 RO:0002234 gomodel:YeastPathways_PWY3O-1565/6a4c244800003261."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/14; endpoint types: /individuals/46/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-016_524032bb326d	gomodel:YeastPathways_PWY3O-1565/6a4c244800003247	RO:0002234	CHEBI:58601	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003247 RO:0002234 gomodel:CHEBI_58601_PHOSPHOGLUCMUT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/15; endpoint types: /individuals/36/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-017_e849e536065b	SGD:S000001518	pathwaymech:enables	gomodel:GLUC1PURIDYLTRANS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:GLUC1PURIDYLTRANS-RXN RO:0002333 gomodel:YKL035W-MONOMER_GLUC1PURIDYLTRANS-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/16; endpoint types: /individuals/9/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-018_fcd1a5f79c58	gomodel:YeastPathways_PWY3O-1565/6a4c244800003258	BFO:0000050	GO:0016051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003258 BFO:0000050 gomodel:YeastPathways_PWY3O-1565/YeastPathways_PWY3O-1565."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/17; endpoint types: /individuals/46/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-019_302efd151bc2	gomodel:2.4.1.117-RXN	RO:0002234	CHEBI:57525	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:2.4.1.117-RXN RO:0002234 gomodel:CHEBI_57525_2.4.1.117-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/18; endpoint types: /individuals/32/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-020_88ec47b2269a	gomodel:GLUC1PURIDYLTRANS-RXN	RO:0002413	gomodel:2.4.1.117-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:GLUC1PURIDYLTRANS-RXN RO:0002413 gomodel:2.4.1.117-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/19; endpoint types: /individuals/9/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-021_7f692de8501e	gomodel:PHOSPHOGLUCMUT-RXN	RO:0002234	CHEBI:58601	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOGLUCMUT-RXN RO:0002234 gomodel:CHEBI_58601_PHOSPHOGLUCMUT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/20; endpoint types: /individuals/10/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-023_e1b459d710ea	gomodel:PHOSPHOGLUCMUT-RXN	RO:0002233	CHEBI:4170	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOGLUCMUT-RXN RO:0002233 gomodel:CHEBI_4170_PHOSPHOGLUCMUT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/22; endpoint types: /individuals/10/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-024_369cbee02506	SGD:S000004711	pathwaymech:enables	gomodel:YeastPathways_PWY3O-1565/6a4c244800003247	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003247 RO:0002333 gomodel:YeastPathways_PWY3O-1565/6a4c244800003250."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/23; endpoint types: /individuals/36/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-025_941e2fe7e64c	SGD:S000001610	pathwaymech:enables	gomodel:PHOSPHOGLUCMUT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOGLUCMUT-RXN RO:0002333 gomodel:YeastPathways_PWY3O-1565/6690711d00000641."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/24; endpoint types: /individuals/10/type; /individuals/63/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-026_3906a69fbed2	SGD:S000001004	pathwaymech:enables	gomodel:YeastPathways_PWY3O-1565/6a4c244800003258	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003258 RO:0002333 gomodel:YeastPathways_PWY3O-1565/6a4c244800003263."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/25; endpoint types: /individuals/46/type; /individuals/50/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-027_06f93e581354	gomodel:YeastPathways_PWY3O-1565/6a4c244800003247	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003247 BFO:0000066 gomodel:YeastPathways_PWY3O-1565/6a4c244800003251."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/26; endpoint types: /individuals/36/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-028_2ef1a76b9245	gomodel:YeastPathways_PWY3O-1565/6a4c244800003247	RO:0002413	gomodel:GLUC1PURIDYLTRANS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003247 RO:0002413 gomodel:GLUC1PURIDYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/27; endpoint types: /individuals/36/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-029_975d426de6ce	gomodel:YeastPathways_PWY3O-1565/6a4c244800003258	RO:0002233	CHEBI:58601	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003258 RO:0002233 gomodel:CHEBI_58601_PHOSPHOGLUCMUT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/28; endpoint types: /individuals/46/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-030_9fd2e3e83c4e	gomodel:GLUC1PURIDYLTRANS-RXN	RO:0002234	CHEBI:58885	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:GLUC1PURIDYLTRANS-RXN RO:0002234 gomodel:CHEBI_58885_GLUC1PURIDYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/29; endpoint types: /individuals/9/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-031_682351ca65d3	gomodel:2.4.1.117-RXN	RO:0002233	CHEBI:16214	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:2.4.1.117-RXN RO:0002233 gomodel:CHEBI_16214_2.4.1.117-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/30; endpoint types: /individuals/32/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-032_ec42e30c7e89	gomodel:GLUC1PURIDYLTRANS-RXN	RO:0002233	CHEBI:58601	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:GLUC1PURIDYLTRANS-RXN RO:0002233 gomodel:CHEBI_58601_PHOSPHOGLUCMUT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/31; endpoint types: /individuals/9/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-033_51fa46faf252	gomodel:GLUC1PURIDYLTRANS-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:GLUC1PURIDYLTRANS-RXN BFO:0000066 gomodel:reaction_GLUC1PURIDYLTRANS-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/32; endpoint types: /individuals/9/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-034_8f0a3ace5bfe	gomodel:YeastPathways_PWY3O-1565/6a4c244800003258	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003258 RO:0002233 gomodel:YeastPathways_PWY3O-1565/6a4c244800003259."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/33; endpoint types: /individuals/46/type; /individuals/47/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-035_194e78354e86	gomodel:YeastPathways_PWY3O-1565/6a4c244800003247	BFO:0000050	GO:0016051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003247 BFO:0000050 gomodel:YeastPathways_PWY3O-1565/YeastPathways_PWY3O-1565."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/34; endpoint types: /individuals/36/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-036_994598a7dd92	gomodel:YeastPathways_PWY3O-1565/6a4c244800003258	RO:0002413	gomodel:2.4.1.117-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003258 RO:0002413 gomodel:2.4.1.117-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/35; endpoint types: /individuals/46/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-037_fc2ff0347ebc	gomodel:YeastPathways_PWY3O-1565/6a4c244800003258	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003258 BFO:0000066 gomodel:YeastPathways_PWY3O-1565/6a4c244800003264."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/36; endpoint types: /individuals/46/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-038_7f8d0d292d1b	gomodel:2.4.1.117-RXN	BFO:0000050	GO:0016051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:2.4.1.117-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-1565/YeastPathways_PWY3O-1565."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/37; endpoint types: /individuals/32/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_edge-039_17be5ab956e8	gomodel:PHOSPHOGLUCMUT-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1565		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOGLUCMUT-RXN BFO:0000066 gomodel:reaction_PHOSPHOGLUCMUT-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-1565.json#/facts/38; endpoint types: /individuals/10/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1565"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json"", ""title"": ""SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_location-52ca1ef25ec9_d2cfb7403689	SGD:S000006148	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40350	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:8076653) Topology: Single-pass membrane protein. Source qualification: Its interaction with the substrate UDP-glucose may occur at the cytoplasmic side of the ER, whereas the steps utilizing dolichyl beta-D-glucosyl phosphate take place in the lumen of the ER	"[{""reference_id"": ""UniProtKB:P40350"", ""source_assertion"": ""UniProtKB:P40350 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3740/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P40350"", ""source_assertion"": ""UniProtKB:P40350 has the exact SGD cross-reference SGD:S000006148."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3740/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40350"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40350 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_location-bdb7eec3df16_61146062bdc3	SGD:S000004711	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37012	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:8385141)	"[{""reference_id"": ""UniProtKB:P37012"", ""source_assertion"": ""UniProtKB:P37012 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1251/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P37012"", ""source_assertion"": ""UniProtKB:P37012 has the exact SGD cross-reference SGD:S000004711."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1251/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P37012"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P37012 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_location-f282e8da1094_f34b08a7e0de	SGD:S000001610	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33401	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P33401"", ""source_assertion"": ""UniProtKB:P33401 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1085/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P33401"", ""source_assertion"": ""UniProtKB:P33401 has the exact SGD cross-reference SGD:S000001610."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1085/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P33401"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P33401 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_location-55bba2410641_886dda017e1c	gomodel:2.4.1.117-RXN	BFO:0000066	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40350	Activity compartment supported by an inspected functional annotation. ECO:0000269 (PubMed:8076653). Alternative isoenzymes may function elsewhere.	"[{""reference_id"": ""UniProtKB:P40350"", ""source_assertion"": ""UniProtKB:P40350 describes the corresponding catalytic function in the endoplasmic reticulum membrane; this projection applies to the activity enabled by SGD:S000006148."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3740/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40350"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40350 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_cofactor-0945beb9b2eb_b5da86026e36	SGD:S000004711	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37012	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805) Binds 1 magnesium ion per subunit. Can also use Zn(2+) as cofactor. UniProt note evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805)	"[{""reference_id"": ""UniProtKB:P37012"", ""source_assertion"": ""UniProtKB:P37012 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/comments/0/cofactors/0; /results/1251/comments/0/note""}, {""reference_id"": ""UniProtKB:P37012"", ""source_assertion"": ""UniProtKB:P37012 has the exact SGD cross-reference SGD:S000004711."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P37012"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P37012 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_cofactor-02ad2260b7d9_3f53bd0aa938	SGD:S000004711	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37012	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805) Binds 1 magnesium ion per subunit. Can also use Zn(2+) as cofactor. UniProt note evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805)	"[{""reference_id"": ""UniProtKB:P37012"", ""source_assertion"": ""UniProtKB:P37012 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/comments/0/cofactors/1; /results/1251/comments/0/note""}, {""reference_id"": ""UniProtKB:P37012"", ""source_assertion"": ""UniProtKB:P37012 has the exact SGD cross-reference SGD:S000004711."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P37012"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P37012 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1565_cofactor-ad9ff5447ab5_a60acda55df1	SGD:S000001610	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33401	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00949) Binds 1 Mg(2+) ion per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00949)	"[{""reference_id"": ""UniProtKB:P33401"", ""source_assertion"": ""UniProtKB:P33401 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1085/comments/0/cofactors/0; /results/1085/comments/0/note""}, {""reference_id"": ""UniProtKB:P33401"", ""source_assertion"": ""UniProtKB:P33401 has the exact SGD cross-reference SGD:S000001610."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1085/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P33401"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P33401 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-001_b907f321f61b	SGD:S000002213	pathwaymech:enables	RHEA:15230	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41940|gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:MANNPGUANYLTRANGDP-RXN RO:0002333 gomodel:YDL055C-MONOMER_MANNPGUANYLTRANGDP-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/0; endpoint types: /individuals/10/type; /individuals/13/type""}, {""reference_id"": ""UniProtKB:P41940"", ""source_assertion"": ""UniProtKB:P41940 annotates alpha-D-mannose 1-phosphate plus GTP yielding GDP-alpha-D-mannose and diphosphate (RHEA:15229), correcting the imported GDP/orthophosphate reaction."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3806/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P41940"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41940 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-002_f39c6bfcb219	gomodel:2.4.1.83-RXN	BFO:0000050	GO:0006013	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:2.4.1.83-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-123/YeastPathways_PWY3O-123."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/1; endpoint types: /individuals/42/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-003_32cde85ca29e	RHEA:15230	RO:0002413	gomodel:2.4.1.83-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41940|gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:MANNPGUANYLTRANGDP-RXN RO:0002413 gomodel:2.4.1.83-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/2; endpoint types: /individuals/10/type; /individuals/42/type""}, {""reference_id"": ""UniProtKB:P41940"", ""source_assertion"": ""UniProtKB:P41940 annotates alpha-D-mannose 1-phosphate plus GTP yielding GDP-alpha-D-mannose and diphosphate (RHEA:15229), correcting the imported GDP/orthophosphate reaction."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3806/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P41940"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41940 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-004_36197e3063a2	RHEA:15230	RO:0002234	CHEBI:57527	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41940		"[{""reference_id"": ""UniProtKB:P41940"", ""source_assertion"": ""UniProtKB:P41940 annotates alpha-D-mannose 1-phosphate plus GTP yielding GDP-alpha-D-mannose and diphosphate (RHEA:15229), correcting the imported GDP/orthophosphate reaction."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3806/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P41940"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41940 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-005_a9f0fe08f6ba	gomodel:2.4.1.83-RXN	RO:0002233	CHEBI:57527	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:2.4.1.83-RXN RO:0002233 gomodel:CHEBI_57527_MANNPGUANYLTRANGDP-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/4; endpoint types: /individuals/42/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-006_59c1cd1a7117	gomodel:2.4.1.83-RXN	RO:0002234	CHEBI:58189	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:2.4.1.83-RXN RO:0002234 gomodel:CHEBI_58189_2.4.1.83-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/5; endpoint types: /individuals/42/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-007_565c10dc6be7	RHEA:15230	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41940|gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:MANNPGUANYLTRANGDP-RXN BFO:0000066 gomodel:reaction_MANNPGUANYLTRANGDP-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/6; endpoint types: /individuals/10/type; /individuals/39/type""}, {""reference_id"": ""UniProtKB:P41940"", ""source_assertion"": ""UniProtKB:P41940 annotates alpha-D-mannose 1-phosphate plus GTP yielding GDP-alpha-D-mannose and diphosphate (RHEA:15229), correcting the imported GDP/orthophosphate reaction."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3806/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P41940"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41940 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-008_02c47ba017fa	gomodel:MANNPISOM-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:MANNPISOM-RXN BFO:0000066 gomodel:reaction_MANNPISOM-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/7; endpoint types: /individuals/11/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-009_85436bf5a6d3	RHEA:15230	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41940		"[{""reference_id"": ""UniProtKB:P41940"", ""source_assertion"": ""UniProtKB:P41940 annotates alpha-D-mannose 1-phosphate plus GTP yielding GDP-alpha-D-mannose and diphosphate (RHEA:15229), correcting the imported GDP/orthophosphate reaction."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3806/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P41940"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41940 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-010_3ac0997af0a0	gomodel:MANNPISOM-RXN	RO:0002413	gomodel:PHOSMANMUT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:MANNPISOM-RXN RO:0002413 gomodel:PHOSMANMUT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/9; endpoint types: /individuals/11/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-011_395b50008190	gomodel:MANNPISOM-RXN	RO:0002233	CHEBI:57634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:MANNPISOM-RXN RO:0002233 gomodel:CHEBI_57634_MANNPISOM-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/10; endpoint types: /individuals/11/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-012_af11953ea43c	RHEA:15230	RO:0002233	CHEBI:58409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41940		"[{""reference_id"": ""UniProtKB:P41940"", ""source_assertion"": ""UniProtKB:P41940 annotates alpha-D-mannose 1-phosphate plus GTP yielding GDP-alpha-D-mannose and diphosphate (RHEA:15229), correcting the imported GDP/orthophosphate reaction."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3806/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P41940"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41940 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-013_a52cd9aa4d22	gomodel:2.4.1.83-RXN	RO:0002233	CHEBI:16214	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:2.4.1.83-RXN RO:0002233 gomodel:CHEBI_16214_2.4.1.83-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/12; endpoint types: /individuals/42/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-014_8c2f813117ae	gomodel:2.4.1.83-RXN	RO:0002234	CHEBI:15809	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:2.4.1.83-RXN RO:0002234 gomodel:CHEBI_15809_2.4.1.83-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/13; endpoint types: /individuals/42/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-015_7428fec52005	RHEA:15230	RO:0002234	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41940		"[{""reference_id"": ""UniProtKB:P41940"", ""source_assertion"": ""UniProtKB:P41940 annotates alpha-D-mannose 1-phosphate plus GTP yielding GDP-alpha-D-mannose and diphosphate (RHEA:15229), correcting the imported GDP/orthophosphate reaction."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3806/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P41940"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41940 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-016_96483c6ac7aa	gomodel:PHOSMANMUT-RXN	RO:0002413	RHEA:15230	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41940|gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:PHOSMANMUT-RXN RO:0002413 gomodel:MANNPGUANYLTRANGDP-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/15; endpoint types: /individuals/12/type; /individuals/10/type""}, {""reference_id"": ""UniProtKB:P41940"", ""source_assertion"": ""UniProtKB:P41940 annotates alpha-D-mannose 1-phosphate plus GTP yielding GDP-alpha-D-mannose and diphosphate (RHEA:15229), correcting the imported GDP/orthophosphate reaction."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3806/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P41940"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41940 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-017_9220ef56b1e1	gomodel:MANNPISOM-RXN	BFO:0000050	GO:0006013	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:MANNPISOM-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-123/YeastPathways_PWY3O-123."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/16; endpoint types: /individuals/11/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-018_5308366a7c0c	gomodel:MANNPISOM-RXN	RO:0002234	CHEBI:48066	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:MANNPISOM-RXN RO:0002234 gomodel:CHEBI_48066_MANNPISOM-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/17; endpoint types: /individuals/11/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-019_552804c4c46e	RHEA:15230	RO:0002233	CHEBI:37565	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41940		"[{""reference_id"": ""UniProtKB:P41940"", ""source_assertion"": ""UniProtKB:P41940 annotates alpha-D-mannose 1-phosphate plus GTP yielding GDP-alpha-D-mannose and diphosphate (RHEA:15229), correcting the imported GDP/orthophosphate reaction."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3806/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P41940"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41940 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-021_c76b688e1672	gomodel:PHOSMANMUT-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:PHOSMANMUT-RXN BFO:0000066 gomodel:reaction_PHOSMANMUT-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/20; endpoint types: /individuals/12/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-022_b1410f51b6bd	gomodel:PHOSMANMUT-RXN	RO:0002234	CHEBI:58409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:PHOSMANMUT-RXN RO:0002234 gomodel:CHEBI_58409_PHOSMANMUT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/21; endpoint types: /individuals/12/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-023_573e19aa7845	SGD:S000006387	pathwaymech:enables	gomodel:2.4.1.83-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:2.4.1.83-RXN RO:0002333 gomodel:YPR183W-MONOMER_2.4.1.83-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/22; endpoint types: /individuals/42/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-024_548bf1b77e50	gomodel:PHOSMANMUT-RXN	RO:0002233	CHEBI:48066	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:PHOSMANMUT-RXN RO:0002233 gomodel:CHEBI_48066_MANNPISOM-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/23; endpoint types: /individuals/12/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-025_837e7ef67cba	SGD:S000001849	pathwaymech:enables	gomodel:PHOSMANMUT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:PHOSMANMUT-RXN RO:0002333 gomodel:YFL045C-MONOMER_PHOSMANMUT-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/24; endpoint types: /individuals/12/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-026_ea24ada0c250	SGD:S000000805	pathwaymech:enables	gomodel:MANNPISOM-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:MANNPISOM-RXN RO:0002333 gomodel:YER003C-MONOMER_MANNPISOM-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/25; endpoint types: /individuals/11/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-027_1c74d4997f13	gomodel:PHOSMANMUT-RXN	BFO:0000050	GO:0006013	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:PHOSMANMUT-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-123/YeastPathways_PWY3O-123."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/26; endpoint types: /individuals/12/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_edge-028_e806760d6e86	RHEA:15230	BFO:0000050	GO:0006013	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41940|gomodel:YeastPathways_PWY3O-123		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_assertion"": ""The model asserts gomodel:MANNPGUANYLTRANGDP-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-123/YeastPathways_PWY3O-123."", ""source_locator"": ""./YeastPathways_PWY3O-123.json#/facts/27; endpoint types: /individuals/10/type; /individuals/43/type""}, {""reference_id"": ""UniProtKB:P41940"", ""source_assertion"": ""UniProtKB:P41940 annotates alpha-D-mannose 1-phosphate plus GTP yielding GDP-alpha-D-mannose and diphosphate (RHEA:15229), correcting the imported GDP/orthophosphate reaction."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3806/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P41940"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41940 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_PWY3O-123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY3O-123.json"", ""title"": ""SGD GO-CAM dolichyl phosphate D-mannose biosynthesis pathway PWY3O-123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_location-00a5ea9c7818_b2bba3482376	SGD:S000002213	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41940	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:9195935)	"[{""reference_id"": ""UniProtKB:P41940"", ""source_assertion"": ""UniProtKB:P41940 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3806/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P41940"", ""source_assertion"": ""UniProtKB:P41940 has the exact SGD cross-reference SGD:S000002213."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3806/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P41940"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41940 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_location-647cc062d11d_10eed2aa5b9e	SGD:S000006387	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P14020	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:15657391) Topology: Single-pass type IV membrane protein. Orientation: Cytoplasmic side.	"[{""reference_id"": ""UniProtKB:P14020"", ""source_assertion"": ""UniProtKB:P14020 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/376/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P14020"", ""source_assertion"": ""UniProtKB:P14020 has the exact SGD cross-reference SGD:S000006387."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/376/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P14020"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P14020 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_location-6055efb3e8c8_bbc4e047f9bc	SGD:S000001849	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07283	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:3905826)	"[{""reference_id"": ""UniProtKB:P07283"", ""source_assertion"": ""UniProtKB:P07283 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/187/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07283"", ""source_assertion"": ""UniProtKB:P07283 has the exact SGD cross-reference SGD:S000001849."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/187/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07283"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07283 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_location-b0affdb6241d_6f9d3b83bf08	SGD:S000000805	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P29952	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P29952"", ""source_assertion"": ""UniProtKB:P29952 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/822/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P29952"", ""source_assertion"": ""UniProtKB:P29952 has the exact SGD cross-reference SGD:S000000805."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/822/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P29952"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P29952 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_cofactor-91a4950388d1_c9dad670e602	SGD:S000006387	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P14020	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q8U4M3) Binds 1 divalent metal cation. UniProt note evidence: ECO:0000250 (UniProtKB:Q8U4M3)	"[{""reference_id"": ""UniProtKB:P14020"", ""source_assertion"": ""UniProtKB:P14020 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/376/comments/0/cofactors/0; /results/376/comments/0/note""}, {""reference_id"": ""UniProtKB:P14020"", ""source_assertion"": ""UniProtKB:P14020 has the exact SGD cross-reference SGD:S000006387."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/376/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P14020"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P14020 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_cofactor-3f699747c59e_e6ee52c95045	SGD:S000006387	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P14020	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q8U4M3) Binds 1 divalent metal cation. UniProt note evidence: ECO:0000250 (UniProtKB:Q8U4M3)	"[{""reference_id"": ""UniProtKB:P14020"", ""source_assertion"": ""UniProtKB:P14020 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/376/comments/0/cofactors/1; /results/376/comments/0/note""}, {""reference_id"": ""UniProtKB:P14020"", ""source_assertion"": ""UniProtKB:P14020 has the exact SGD cross-reference SGD:S000006387."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/376/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P14020"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P14020 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_cofactor-41097c192293_aab8f29915d0	SGD:S000006387	pathwaymech:has_cofactor	CHEBI:29108	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P14020	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q8U4M3) Binds 1 divalent metal cation. UniProt note evidence: ECO:0000250 (UniProtKB:Q8U4M3)	"[{""reference_id"": ""UniProtKB:P14020"", ""source_assertion"": ""UniProtKB:P14020 annotates CHEBI:29108 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/376/comments/0/cofactors/2; /results/376/comments/0/note""}, {""reference_id"": ""UniProtKB:P14020"", ""source_assertion"": ""UniProtKB:P14020 has the exact SGD cross-reference SGD:S000006387."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/376/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P14020"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P14020 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-123_cofactor-37cbae61fe33_b307604efed1	SGD:S000000805	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P29952	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified Binds 1 zinc ion per subunit.	"[{""reference_id"": ""UniProtKB:P29952"", ""source_assertion"": ""UniProtKB:P29952 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/822/comments/0/cofactors/0; /results/822/comments/0/note""}, {""reference_id"": ""UniProtKB:P29952"", ""source_assertion"": ""UniProtKB:P29952 has the exact SGD cross-reference SGD:S000000805."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/822/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P29952"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P29952 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-001_9e67bc5ae6e6	CHEBI:37568	pathwaymech:consumes	RHEA:15226	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15226		"[{""reference_id"": ""RHEA:15226"", ""source_assertion"": ""RHEA:15226 assigns CHEBI:37568 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/15226 rh:substrates; http://rdf.rhea-db.org/15225_L rh:contains1 http://rdf.rhea-db.org/Participant_15225_compound_6436; http://rdf.rhea-db.org/Participant_15225_compound_6436 rh:compound http://rdf.rhea-db.org/Compound_6436; rh:chebi""}]"	"[{""id"": ""RHEA:15226"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTTP + alpha-D-glucose 1-phosphate + H(+) => dTDP-alpha-D-glucose + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-002_8fb41ed5e35f	CHEBI:58601	pathwaymech:consumes	RHEA:15226	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15226		"[{""reference_id"": ""RHEA:15226"", ""source_assertion"": ""RHEA:15226 assigns CHEBI:58601 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/15226 rh:substrates; http://rdf.rhea-db.org/15225_L rh:contains1 http://rdf.rhea-db.org/Participant_15225_compound_3943; http://rdf.rhea-db.org/Participant_15225_compound_3943 rh:compound http://rdf.rhea-db.org/Compound_3943; rh:chebi""}]"	"[{""id"": ""RHEA:15226"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTTP + alpha-D-glucose 1-phosphate + H(+) => dTDP-alpha-D-glucose + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-003_9f8153f8789c	CHEBI:15378	pathwaymech:consumes	RHEA:15226	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15226		"[{""reference_id"": ""RHEA:15226"", ""source_assertion"": ""RHEA:15226 assigns CHEBI:15378 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/15226 rh:substrates; http://rdf.rhea-db.org/15225_L rh:contains1 http://rdf.rhea-db.org/Participant_15225_compound_3249; http://rdf.rhea-db.org/Participant_15225_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:15226"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTTP + alpha-D-glucose 1-phosphate + H(+) => dTDP-alpha-D-glucose + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-004_d953a979a1d4	RHEA:15226	pathwaymech:produces	CHEBI:57477	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15226		"[{""reference_id"": ""RHEA:15226"", ""source_assertion"": ""RHEA:15226 assigns CHEBI:57477 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/15226 rh:products; http://rdf.rhea-db.org/15225_R rh:contains1 http://rdf.rhea-db.org/Participant_15225_compound_3802; http://rdf.rhea-db.org/Participant_15225_compound_3802 rh:compound http://rdf.rhea-db.org/Compound_3802; rh:chebi""}]"	"[{""id"": ""RHEA:15226"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTTP + alpha-D-glucose 1-phosphate + H(+) => dTDP-alpha-D-glucose + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-005_9be93b23c3b1	RHEA:15226	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15226		"[{""reference_id"": ""RHEA:15226"", ""source_assertion"": ""RHEA:15226 assigns CHEBI:33019 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/15226 rh:products; http://rdf.rhea-db.org/15225_R rh:contains1 http://rdf.rhea-db.org/Participant_15225_compound_2106; http://rdf.rhea-db.org/Participant_15225_compound_2106 rh:compound http://rdf.rhea-db.org/Compound_2106; rh:chebi""}]"	"[{""id"": ""RHEA:15226"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTTP + alpha-D-glucose 1-phosphate + H(+) => dTDP-alpha-D-glucose + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-006_b5a581e15a3b	CHEBI:57477	pathwaymech:consumes	RHEA:17222	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17222		"[{""reference_id"": ""RHEA:17222"", ""source_assertion"": ""RHEA:17222 assigns CHEBI:57477 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/17222 rh:substrates; http://rdf.rhea-db.org/17221_L rh:contains1 http://rdf.rhea-db.org/Participant_17221_compound_3802; http://rdf.rhea-db.org/Participant_17221_compound_3802 rh:compound http://rdf.rhea-db.org/Compound_3802; rh:chebi""}]"	"[{""id"": ""RHEA:17222"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-007_de76d8c28760	RHEA:17222	pathwaymech:produces	CHEBI:57649	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17222		"[{""reference_id"": ""RHEA:17222"", ""source_assertion"": ""RHEA:17222 assigns CHEBI:57649 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/17222 rh:products; http://rdf.rhea-db.org/17221_R rh:contains1 http://rdf.rhea-db.org/Participant_17221_compound_4008; http://rdf.rhea-db.org/Participant_17221_compound_4008 rh:compound http://rdf.rhea-db.org/Compound_4008; rh:chebi""}]"	"[{""id"": ""RHEA:17222"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-008_b79165e24203	RHEA:17222	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17222		"[{""reference_id"": ""RHEA:17222"", ""source_assertion"": ""RHEA:17222 assigns CHEBI:15377 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/17222 rh:products; http://rdf.rhea-db.org/17221_R rh:contains1 http://rdf.rhea-db.org/Participant_17221_compound_1283; http://rdf.rhea-db.org/Participant_17221_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; rh:chebi""}]"	"[{""id"": ""RHEA:17222"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-009_2bbdeb894d03	CHEBI:57649	pathwaymech:consumes	RHEA:16970	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16970		"[{""reference_id"": ""RHEA:16970"", ""source_assertion"": ""RHEA:16970 assigns CHEBI:57649 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/16970 rh:substrates; http://rdf.rhea-db.org/16969_L rh:contains1 http://rdf.rhea-db.org/Participant_16969_compound_4008; http://rdf.rhea-db.org/Participant_16969_compound_4008 rh:compound http://rdf.rhea-db.org/Compound_4008; rh:chebi""}]"	"[{""id"": ""RHEA:16970"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-beta-L-rhamnose"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-010_95a193514850	RHEA:16970	pathwaymech:produces	CHEBI:62830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16970		"[{""reference_id"": ""RHEA:16970"", ""source_assertion"": ""RHEA:16970 assigns CHEBI:62830 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/16970 rh:products; http://rdf.rhea-db.org/16969_R rh:contains1 http://rdf.rhea-db.org/Participant_16969_compound_7498; http://rdf.rhea-db.org/Participant_16969_compound_7498 rh:compound http://rdf.rhea-db.org/Compound_7498; rh:chebi""}]"	"[{""id"": ""RHEA:16970"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-beta-L-rhamnose"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-011_cc481edfcf3e	CHEBI:62830	pathwaymech:consumes	RHEA:21798	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21798		"[{""reference_id"": ""RHEA:21798"", ""source_assertion"": ""RHEA:21798 assigns CHEBI:62830 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/21798 rh:substrates; http://rdf.rhea-db.org/21796_R rh:contains1 http://rdf.rhea-db.org/Participant_21796_compound_7498; http://rdf.rhea-db.org/Participant_21796_compound_7498 rh:compound http://rdf.rhea-db.org/Compound_7498; rh:chebi""}]"	"[{""id"": ""RHEA:21798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-4-dehydro-beta-L-rhamnose + NADPH + H(+) => dTDP-beta-L-rhamnose + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-012_2b730cc477bc	CHEBI:57783	pathwaymech:consumes	RHEA:21798	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21798		"[{""reference_id"": ""RHEA:21798"", ""source_assertion"": ""RHEA:21798 assigns CHEBI:57783 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/21798 rh:substrates; http://rdf.rhea-db.org/21796_R rh:contains1 http://rdf.rhea-db.org/Participant_21796_compound_3438; http://rdf.rhea-db.org/Participant_21796_compound_3438 rh:compound http://rdf.rhea-db.org/Compound_3438; rh:chebi""}]"	"[{""id"": ""RHEA:21798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-4-dehydro-beta-L-rhamnose + NADPH + H(+) => dTDP-beta-L-rhamnose + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-013_a44606c1b4dc	CHEBI:15378	pathwaymech:consumes	RHEA:21798	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21798		"[{""reference_id"": ""RHEA:21798"", ""source_assertion"": ""RHEA:21798 assigns CHEBI:15378 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/21798 rh:substrates; http://rdf.rhea-db.org/21796_R rh:contains1 http://rdf.rhea-db.org/Participant_21796_compound_3249; http://rdf.rhea-db.org/Participant_21796_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:21798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-4-dehydro-beta-L-rhamnose + NADPH + H(+) => dTDP-beta-L-rhamnose + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-014_627ac6a92a39	RHEA:21798	pathwaymech:produces	CHEBI:57510	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21798		"[{""reference_id"": ""RHEA:21798"", ""source_assertion"": ""RHEA:21798 assigns CHEBI:57510 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/21798 rh:products; http://rdf.rhea-db.org/21796_L rh:contains1 http://rdf.rhea-db.org/Participant_21796_compound_1098; http://rdf.rhea-db.org/Participant_21796_compound_1098 rh:compound http://rdf.rhea-db.org/Compound_1098; rh:chebi""}]"	"[{""id"": ""RHEA:21798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-4-dehydro-beta-L-rhamnose + NADPH + H(+) => dTDP-beta-L-rhamnose + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-015_9487840263cb	RHEA:21798	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21798		"[{""reference_id"": ""RHEA:21798"", ""source_assertion"": ""RHEA:21798 assigns CHEBI:58349 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/21798 rh:products; http://rdf.rhea-db.org/21796_L rh:contains1 http://rdf.rhea-db.org/Participant_21796_compound_5188; http://rdf.rhea-db.org/Participant_21796_compound_5188 rh:compound http://rdf.rhea-db.org/Compound_5188; rh:chebi""}]"	"[{""id"": ""RHEA:21798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-4-dehydro-beta-L-rhamnose + NADPH + H(+) => dTDP-beta-L-rhamnose + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-016_eba733033c65	MetaCyc:CPLX0-8034	pathwaymech:catalyzes	RHEA:15226	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8034|PMID:11697907|RHEA:15226|UniProtKB:P37744	The native tetramer is the catalytic entity; the biosynthetic direction is selected without denying experimentally measured reverse pyrophosphorolysis.	"[{""reference_id"": ""UniProtKB:P37744"", ""source_assertion"": ""P37744 explicitly links catalytic RHEA:15225 and formation of dTDP-glucose from dTTP and glucose 1-phosphate, with ECO:0000269 PMID:11697907."", ""source_locator"": ""/comments/0; /comments/1/reaction""}, {""reference_id"": ""RHEA:15226"", ""source_assertion"": ""RHEA:15225 explicitly links directionalReaction RHEA:15226; this is the selected biosynthetic member."", ""source_locator"": ""http://rdf.rhea-db.org/15225 rh:directionalReaction http://rdf.rhea-db.org/15226""}, {""reference_id"": ""MetaCyc:CPLX0-8034"", ""source_assertion"": ""CPLX0-8034 catalyzes DTDPGLUCOSEPP-RXN through DTDPGLUCOSEPP-ENZRXN."", ""source_locator"": ""Protein[@frameid=\""CPLX0-8034\""]/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""PMID:11697907"", ""source_assertion"": ""The indexed primary abstract reports kinetic analysis of E. coli glucose-1-phosphate thymidylyltransferase in both biosynthesis and pyrophosphorolysis directions."", ""source_locator"": ""/resultList/result[id=\""11697907\""]/abstractText""}]"	"[{""id"": ""MetaCyc:CPLX0-8034"", ""source_sha256"": ""c311938fc3d5335a49fab68c5a8fc1922aafc13f7d7ed961c3bad82d5df5c44d"", ""source_version"": ""MetaCyc 22.5; full native XML body retrieved 2026-10-11 UTC"", ""title"": ""Native RmlA/RmlB protein identity and assembly: CPLX0-8034"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8034""}, {""id"": ""PMID:11697907"", ""source_sha256"": ""2f625e84e3c5ce0478cb6638e8e9951a3d0d8da89ca722f9a3baf9346ed75608"", ""source_version"": ""Indexed abstract in Europe PMC core JSON; full publisher article was not accessible; retrieved 2026-10-11 UTC"", ""title"": ""Kinetic and crystallographic analyses support a sequential-ordered bi bi catalytic mechanism for Escherichia coli glucose-1-phosphate thymidylyltransferase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/11697907/""}, {""id"": ""RHEA:15226"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTTP + alpha-D-glucose 1-phosphate + H(+) => dTDP-alpha-D-glucose + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P37744"", ""source_sha256"": ""7939e76649a90f2f0382c8bff0c3093647372e7077980e78cc4a720f68e372b3"", ""source_version"": ""UniProt 2026_03; complete JSON entry retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 Glucose-1-phosphate thymidylyltransferase 1"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37744.json""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-017_d692042f8c07	MetaCyc:DTDPGLUCDEHYDRAT-CPLX	pathwaymech:catalyzes	RHEA:17222	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DTDPGLUCDEHYDRAT-CPLX|RHEA:17222|UniProtKB:P37759	Reviewed functional inference is retained at its stated tier. Direct RffG experiments and the older E. coli B mass measurement are not relabeled as K-12 RmlB measurements.	"[{""reference_id"": ""UniProtKB:P37759"", ""source_assertion"": ""P37759 links RHEA:17221 and oxidation/dehydration/rereduction of dTDP-glucose with ECO:0000250 UniProtKB:P27830; this is an inference from RffG, not a purified K-12 RmlB assay."", ""source_locator"": ""/comments/0; /comments/1/reaction""}, {""reference_id"": ""RHEA:17222"", ""source_assertion"": ""RHEA:17221 explicitly links directionalReaction RHEA:17222; this is the selected biosynthetic member."", ""source_locator"": ""http://rdf.rhea-db.org/17221 rh:directionalReaction http://rdf.rhea-db.org/17222""}, {""reference_id"": ""MetaCyc:DTDPGLUCDEHYDRAT-CPLX"", ""source_assertion"": ""The native dimer catalyzes DTDPGLUCDEHYDRAT-RXN through DTDPGLUCDEHYDRAT-ENZRXN."", ""source_locator"": ""Protein[@frameid=\""DTDPGLUCDEHYDRAT-CPLX\""]/catalyzes/Enzymatic-Reaction/reaction""}]"	"[{""id"": ""MetaCyc:DTDPGLUCDEHYDRAT-CPLX"", ""source_sha256"": ""be5fda0653ef37dd9136f81956fb376a7577bbbb60338d9d1c2da276709f1563"", ""source_version"": ""MetaCyc 22.5; full native XML body retrieved 2026-10-11 UTC"", ""title"": ""Native RmlA/RmlB protein identity and assembly: DTDPGLUCDEHYDRAT-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DTDPGLUCDEHYDRAT-CPLX""}, {""id"": ""RHEA:17222"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P37759"", ""source_sha256"": ""c1c53b12b07571ace6a3edfb5dc8e24acf93d48f84a4db272f9c99b1e3726f78"", ""source_version"": ""UniProt 2026_03; complete JSON entry retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 dTDP-glucose 4,6-dehydratase 1"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37759.json""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-018_1a3af5510844	UniProtKB:P37745	pathwaymech:enables	RHEA:16970	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:10217500|RHEA:16970|UniProtKB:P37745	The gene-product role combines K-12 mutant/extract evidence and reviewed exact-reaction inference. It does not establish an independently sufficient K-12 monomer or an obligatory RmlC-RmlD complex.	"[{""reference_id"": ""UniProtKB:P37745"", ""source_assertion"": ""P37745 links RHEA:16969 and C3/C5 epimerization with ECO:0000250 UniProtKB:P26394 (Salmonella); its homodimer annotation has the same inference source."", ""source_locator"": ""/comments/0; /comments/1/reaction; /comments/4""}, {""reference_id"": ""RHEA:16970"", ""source_assertion"": ""RHEA:16969 explicitly links directionalReaction RHEA:16970; this is the selected biosynthetic member."", ""source_locator"": ""http://rdf.rhea-db.org/16969 rh:directionalReaction http://rdf.rhea-db.org/16970""}, {""reference_id"": ""PMID:10217500"", ""source_assertion"": ""All E. coli strains derive from K-12. BW24599 extracts form free 4-keto-rhamnose, unlike the rmlC deletion mutant BW24970. Purified epimerase experiments in the paper use M. tuberculosis RmlC."", ""source_locator"": ""PDF pp.664-668, Table 1, Results, Fig.3 caption and Fig.5""}]"	"[{""id"": ""PMID:10217500"", ""source_sha256"": ""29b2710e332b38917153a118a7799865f765aa3bd097f7389d49fbd961351eef"", ""source_version"": ""Complete primary publisher PDF; pages 663-671; retrieved 2026-10-11 UTC"", ""title"": ""Conversion of dTDP-4-keto-6-deoxyglucose to free dTDP-4-keto-rhamnose by the rmIC gene products of Escherichia coli and Mycobacterium tuberculosis."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/10217500/""}, {""id"": ""RHEA:16970"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-beta-L-rhamnose"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P37745"", ""source_sha256"": ""0cbfd8f3fe413b20fa7378ab44363dbc4ecb5461f76fe63c51d9a2ea95e22ebc"", ""source_version"": ""UniProt 2026_03; complete JSON entry retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 dTDP-4-dehydrorhamnose 3,5-epimerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37745.json""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-019_d098840f8a27	UniProtKB:P37760	pathwaymech:enables	RHEA:21798	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DTDPRHAMSYN-PWY|RHEA:21798|UniProtKB:P37760	This is the probable K-12 RmlD functional assignment, with exact catalysis inferred from Salmonella. The selected NADPH reduction is not evidence that NADH cannot support activity, nor that an isolated monomer is sufficient.	"[{""reference_id"": ""UniProtKB:P37760"", ""source_assertion"": ""P37760 links RHEA:21796 with ECO:0000250 UniProtKB:P26392. Its pathway role is Probable (ECO:0000305 PMID:7517391); NADH/NADPH use and homodimerization are by similarity."", ""source_locator"": ""/comments/0; /comments/1/reaction; /comments/5""}, {""reference_id"": ""RHEA:21798"", ""source_assertion"": ""RHEA:21796 explicitly links directionalReaction RHEA:21798; this is the selected biosynthetic member."", ""source_locator"": ""http://rdf.rhea-db.org/21796 rh:directionalReaction http://rdf.rhea-db.org/21798""}, {""reference_id"": ""MetaCyc:DTDPRHAMSYN-PWY"", ""source_assertion"": ""The native final DTDPDEHYRHAMREDUCT-RXN layout selects R2L from the 4-keto-rhamnose primary compound to dTDP-rhamnose."", ""source_locator"": ""Pathway[@frameid=\""DTDPRHAMSYN-PWY\""]/reaction-layout[Reaction/@frameid=\""DTDPDEHYRHAMREDUCT-RXN\""]""}]"	"[{""id"": ""MetaCyc:DTDPRHAMSYN-PWY"", ""source_sha256"": ""be7f6580697c429251fba8d6a863fa6ee147ae8aa06aac9c18b331e6f39df0b8"", ""source_version"": ""MetaCyc 22.5; full native XML body retrieved 2026-10-11 UTC"", ""title"": ""dTDP-L-rhamnose biosynthesis: complete native four-step boundary"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DTDPRHAMSYN-PWY""}, {""id"": ""RHEA:21798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-4-dehydro-beta-L-rhamnose + NADPH + H(+) => dTDP-beta-L-rhamnose + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P37760"", ""source_sha256"": ""2c3a96b3865c4e7dae800b0cf9290f9cae6157dbf502942d21d99b979c08e9e7"", ""source_version"": ""UniProt 2026_03; complete JSON entry retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 dTDP-4-dehydrorhamnose reductase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37760.json""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-020_796e09efd307	UniProtKB:P37744	BFO:0000050	MetaCyc:CPLX0-8034	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8034|MetaCyc:DTDPGLUCOSEPP-MONOMER|PMID:11697907|UniProtKB:P37744	The subunit node is not assigned independent catalytic sufficiency.	"[{""reference_id"": ""MetaCyc:CPLX0-8034"", ""source_assertion"": ""CPLX0-8034 has 4 copies of DTDPGLUCOSEPP-MONOMER; native species is MG1655, within the selected K-12 scope."", ""source_locator"": ""Protein[@frameid=\""CPLX0-8034\""]/component/Protein; component/coefficient; species/Organism""}, {""reference_id"": ""MetaCyc:DTDPGLUCOSEPP-MONOMER"", ""source_assertion"": ""DTDPGLUCOSEPP-MONOMER has an explicit UNIPROT P37744 unification cross-reference."", ""source_locator"": ""Protein[@frameid=\""DTDPGLUCOSEPP-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid; dblink-relationship""}, {""reference_id"": ""UniProtKB:P37744"", ""source_assertion"": ""SUBUNIT specifies a homotetramer with ECO:0000269 PMID:11697907."", ""source_locator"": ""/comments/6""}, {""reference_id"": ""PMID:11697907"", ""source_assertion"": ""The indexed primary abstract explicitly describes the E. coli enzyme as homotetrameric."", ""source_locator"": ""/resultList/result[id=\""11697907\""]/abstractText""}]"	"[{""id"": ""MetaCyc:CPLX0-8034"", ""source_sha256"": ""c311938fc3d5335a49fab68c5a8fc1922aafc13f7d7ed961c3bad82d5df5c44d"", ""source_version"": ""MetaCyc 22.5; full native XML body retrieved 2026-10-11 UTC"", ""title"": ""Native RmlA/RmlB protein identity and assembly: CPLX0-8034"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8034""}, {""id"": ""MetaCyc:DTDPGLUCOSEPP-MONOMER"", ""source_sha256"": ""5f140744dc36f1b412fcc6973142c4b86e789a9798eb1a69d3878099e02b2cc4"", ""source_version"": ""MetaCyc 22.5; full native XML body retrieved 2026-10-11 UTC"", ""title"": ""Native RmlA/RmlB protein identity and assembly: DTDPGLUCOSEPP-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DTDPGLUCOSEPP-MONOMER""}, {""id"": ""PMID:11697907"", ""source_sha256"": ""2f625e84e3c5ce0478cb6638e8e9951a3d0d8da89ca722f9a3baf9346ed75608"", ""source_version"": ""Indexed abstract in Europe PMC core JSON; full publisher article was not accessible; retrieved 2026-10-11 UTC"", ""title"": ""Kinetic and crystallographic analyses support a sequential-ordered bi bi catalytic mechanism for Escherichia coli glucose-1-phosphate thymidylyltransferase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/11697907/""}, {""id"": ""UniProtKB:P37744"", ""source_sha256"": ""7939e76649a90f2f0382c8bff0c3093647372e7077980e78cc4a720f68e372b3"", ""source_version"": ""UniProt 2026_03; complete JSON entry retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 Glucose-1-phosphate thymidylyltransferase 1"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37744.json""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-021_e4d1eda7fb11	UniProtKB:P37759	BFO:0000050	MetaCyc:DTDPGLUCDEHYDRAT-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DTDPGLUCDEHYDRAT-CPLX|MetaCyc:DTDPGLUCDEHYDRAT-MONOMER|UniProtKB:P37759	The native dimer is corroborated by reviewed similarity annotation; the native 88-kDa experimental citation concerns E. coli B, not a direct K-12 measurement.	"[{""reference_id"": ""MetaCyc:DTDPGLUCDEHYDRAT-CPLX"", ""source_assertion"": ""DTDPGLUCDEHYDRAT-CPLX has 2 copies of DTDPGLUCDEHYDRAT-MONOMER; native species is MG1655, within the selected K-12 scope."", ""source_locator"": ""Protein[@frameid=\""DTDPGLUCDEHYDRAT-CPLX\""]/component/Protein; component/coefficient; species/Organism""}, {""reference_id"": ""MetaCyc:DTDPGLUCDEHYDRAT-MONOMER"", ""source_assertion"": ""DTDPGLUCDEHYDRAT-MONOMER has an explicit UNIPROT P37759 unification cross-reference."", ""source_locator"": ""Protein[@frameid=\""DTDPGLUCDEHYDRAT-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid; dblink-relationship""}, {""reference_id"": ""UniProtKB:P37759"", ""source_assertion"": ""SUBUNIT specifies a homodimer with ECO:0000250 UniProtKB:P27830."", ""source_locator"": ""/comments/5""}]"	"[{""id"": ""MetaCyc:DTDPGLUCDEHYDRAT-CPLX"", ""source_sha256"": ""be5fda0653ef37dd9136f81956fb376a7577bbbb60338d9d1c2da276709f1563"", ""source_version"": ""MetaCyc 22.5; full native XML body retrieved 2026-10-11 UTC"", ""title"": ""Native RmlA/RmlB protein identity and assembly: DTDPGLUCDEHYDRAT-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DTDPGLUCDEHYDRAT-CPLX""}, {""id"": ""MetaCyc:DTDPGLUCDEHYDRAT-MONOMER"", ""source_sha256"": ""7207b23b41f83da621510d8988b201ce1e226f511faacece285daf6ce20df29a"", ""source_version"": ""MetaCyc 22.5; full native XML body retrieved 2026-10-11 UTC"", ""title"": ""Native RmlA/RmlB protein identity and assembly: DTDPGLUCDEHYDRAT-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DTDPGLUCDEHYDRAT-MONOMER""}, {""id"": ""UniProtKB:P37759"", ""source_sha256"": ""c1c53b12b07571ace6a3edfb5dc8e24acf93d48f84a4db272f9c99b1e3726f78"", ""source_version"": ""UniProt 2026_03; complete JSON entry retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 dTDP-glucose 4,6-dehydratase 1"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37759.json""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-022_6e176fb50046	MetaCyc:CPLX0-8034	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37744	Magnesium binding is an explicit experimentally supported annotation, not inferred from an Mg-containing assay mixture.	"[{""reference_id"": ""UniProtKB:P37744"", ""source_assertion"": ""COFACTOR specifies CHEBI:18420 and one Mg(2+) per subunit with ECO:0000269 PMID:11697907. The inspected primary abstract does not itself specify this cofactor."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}]"	"[{""id"": ""UniProtKB:P37744"", ""source_sha256"": ""7939e76649a90f2f0382c8bff0c3093647372e7077980e78cc4a720f68e372b3"", ""source_version"": ""UniProt 2026_03; complete JSON entry retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 Glucose-1-phosphate thymidylyltransferase 1"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37744.json""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-023_21a0b993e816	MetaCyc:DTDPGLUCDEHYDRAT-CPLX	pathwaymech:has_cofactor	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37759	Bound NAD cycles internally during oxidation and rereduction, so it is not a net consumed reactant. Binding and stoichiometry are inferred from the RffG paralog.	"[{""reference_id"": ""UniProtKB:P37759"", ""source_assertion"": ""COFACTOR specifies CHEBI:57540 and one NAD(+) per subunit, ECO:0000250 UniProtKB:P27830. FUNCTION describes oxidation, dehydration and reduction."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note; /comments/0""}]"	"[{""id"": ""UniProtKB:P37759"", ""source_sha256"": ""c1c53b12b07571ace6a3edfb5dc8e24acf93d48f84a4db272f9c99b1e3726f78"", ""source_version"": ""UniProt 2026_03; complete JSON entry retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 dTDP-glucose 4,6-dehydratase 1"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37759.json""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-024_e79cee556ec3	UniProtKB:P37760	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37760	The magnesium-binding annotation is inferred from Salmonella RmlD, as is homodimerization; no direct K-12 metal assay or monomeric sufficiency is claimed.	"[{""reference_id"": ""UniProtKB:P37760"", ""source_assertion"": ""COFACTOR specifies CHEBI:18420 and one Mg(2+) per monomer with ECO:0000250 UniProtKB:P26392."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}]"	"[{""id"": ""UniProtKB:P37760"", ""source_sha256"": ""2c3a96b3865c4e7dae800b0cf9290f9cae6157dbf502942d21d99b979c08e9e7"", ""source_version"": ""UniProt 2026_03; complete JSON entry retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 dTDP-4-dehydrorhamnose reductase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37760.json""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-025_c3b7797afb61	RHEA:15226	BFO:0000050	GO:0019305	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0019305|MetaCyc:DTDPGLUCOSEPP-RXN|MetaCyc:DTDPRHAMSYN-PWY|PMID:10217500|PMID:7517391|RHEA:15226|UniProtKB:P37744		"[{""reference_id"": ""GO:0019305"", ""source_assertion"": ""GO:0019305 is the non-obsolete biological process for dTDP-rhamnose formation; exact synonyms include dTDP-rhamnose biosynthesis."", ""source_locator"": ""/results/0/id; /results/0/name; /results/0/isObsolete; /results/0/definition; /results/0/synonyms""}, {""reference_id"": ""MetaCyc:DTDPRHAMSYN-PWY"", ""source_assertion"": ""The complete native dTDP-L-rhamnose route lists DTDPGLUCOSEPP-RXN and selects L2R for this step."", ""source_locator"": ""Pathway[@frameid=\""DTDPRHAMSYN-PWY\""]/reaction-list; reaction-layout[Reaction/@frameid=\""DTDPGLUCOSEPP-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:DTDPGLUCOSEPP-RXN"", ""source_assertion"": ""DTDPGLUCOSEPP-RXN has explicit RHEA 15228 unification cross-reference."", ""source_locator"": ""Reaction[@frameid=\""DTDPGLUCOSEPP-RXN\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid; dblink-relationship""}, {""reference_id"": ""RHEA:15226"", ""source_assertion"": ""RHEA:15225 explicitly links bidirectionalReaction RHEA:15228 and directionalReaction RHEA:15226."", ""source_locator"": ""http://rdf.rhea-db.org/15225 rh:bidirectionalReaction http://rdf.rhea-db.org/15228; rh:directionalReaction http://rdf.rhea-db.org/15226""}, {""reference_id"": ""UniProtKB:P37744"", ""source_assertion"": ""The reviewed P37744 entry is E. coli K-12 taxon 83333. Its caution states that many K-12 lines fail to express O-antigen because of dTDP-rhamnose biosynthetic or wbbL mutations."", ""source_locator"": ""/organism/taxonId; /comments/9""}, {""reference_id"": ""PMID:7517391"", ""source_assertion"": ""The primary K-12 study identifies four rhamnose pathway genes by homology and distinguishes defective laboratory lineages from an engineered strain with intact rfb genes and O16 antigen."", ""source_locator"": ""PDF pp.4144,4150; abstract; Results and Discussion, TDP-Rha biosynthetic pathway genes""}, {""reference_id"": ""PMID:10217500"", ""source_assertion"": ""Table 1 identifies all studied E. coli strains as K-12 derivatives. Extracts from repaired-rfb BW24599 synthesize dTDP-rhamnose; rmlC-deletion extracts do not."", ""source_locator"": ""PDF pp.664,668; Table 1; Results, dTDP-rha from dTDP-glc""}]"	"[{""id"": ""GO:0019305"", ""source_sha256"": ""a68a207e9cdf3656ff12299acd94650c879172d7115d4ad9ef1a61684dc70b39"", ""source_version"": ""QuickGO term response retrieved 2026-10-11 UTC"", ""title"": ""Gene Ontology dTDP-rhamnose biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0019305""}, {""id"": ""MetaCyc:DTDPGLUCOSEPP-RXN"", ""source_sha256"": ""1d79af35de77e537970fa9055d0eaed663cb6ee0c410f2ed479e090fde02e922"", ""source_version"": ""MetaCyc 22.5; full native XML body retrieved 2026-10-11 UTC"", ""title"": ""Native DTDPGLUCOSEPP-RXN reaction and cross-references"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DTDPGLUCOSEPP-RXN""}, {""id"": ""MetaCyc:DTDPRHAMSYN-PWY"", ""source_sha256"": ""be7f6580697c429251fba8d6a863fa6ee147ae8aa06aac9c18b331e6f39df0b8"", ""source_version"": ""MetaCyc 22.5; full native XML body retrieved 2026-10-11 UTC"", ""title"": ""dTDP-L-rhamnose biosynthesis: complete native four-step boundary"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DTDPRHAMSYN-PWY""}, {""id"": ""PMID:10217500"", ""source_sha256"": ""29b2710e332b38917153a118a7799865f765aa3bd097f7389d49fbd961351eef"", ""source_version"": ""Complete primary publisher PDF; pages 663-671; retrieved 2026-10-11 UTC"", ""title"": ""Conversion of dTDP-4-keto-6-deoxyglucose to free dTDP-4-keto-rhamnose by the rmIC gene products of Escherichia coli and Mycobacterium tuberculosis."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/10217500/""}, {""id"": ""PMID:7517391"", ""source_sha256"": ""8b2f97df926c235493ba4f5204a782af235b3825f966cb472f98ecd1fc9b86b3"", ""source_version"": ""Complete primary PDF; pages 4144-4156; retrieved 2026-10-11 UTC"", ""title"": ""Structure of the O antigen of Escherichia coli K-12 and the sequence of its rfb gene cluster."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/7517391/""}, {""id"": ""RHEA:15226"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTTP + alpha-D-glucose 1-phosphate + H(+) => dTDP-alpha-D-glucose + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P37744"", ""source_sha256"": ""7939e76649a90f2f0382c8bff0c3093647372e7077980e78cc4a720f68e372b3"", ""source_version"": ""UniProt 2026_03; complete JSON entry retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 Glucose-1-phosphate thymidylyltransferase 1"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37744.json""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-026_33579184b088	RHEA:17222	BFO:0000050	GO:0019305	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0019305|MetaCyc:DTDPGLUCDEHYDRAT-RXN|MetaCyc:DTDPRHAMSYN-PWY|RHEA:17222		"[{""reference_id"": ""GO:0019305"", ""source_assertion"": ""GO:0019305 is the non-obsolete biological process for dTDP-rhamnose formation; exact synonyms include dTDP-rhamnose biosynthesis."", ""source_locator"": ""/results/0/id; /results/0/name; /results/0/isObsolete; /results/0/definition; /results/0/synonyms""}, {""reference_id"": ""MetaCyc:DTDPRHAMSYN-PWY"", ""source_assertion"": ""The complete native dTDP-L-rhamnose route lists DTDPGLUCDEHYDRAT-RXN and selects L2R for this step."", ""source_locator"": ""Pathway[@frameid=\""DTDPRHAMSYN-PWY\""]/reaction-list; reaction-layout[Reaction/@frameid=\""DTDPGLUCDEHYDRAT-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:DTDPGLUCDEHYDRAT-RXN"", ""source_assertion"": ""DTDPGLUCDEHYDRAT-RXN has explicit RHEA 17221 unification cross-reference."", ""source_locator"": ""Reaction[@frameid=\""DTDPGLUCDEHYDRAT-RXN\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid; dblink-relationship""}, {""reference_id"": ""RHEA:17222"", ""source_assertion"": ""RHEA:17221 explicitly links directionalReaction RHEA:17222; this is the selected biosynthetic member."", ""source_locator"": ""http://rdf.rhea-db.org/17221 rh:directionalReaction http://rdf.rhea-db.org/17222""}]"	"[{""id"": ""GO:0019305"", ""source_sha256"": ""a68a207e9cdf3656ff12299acd94650c879172d7115d4ad9ef1a61684dc70b39"", ""source_version"": ""QuickGO term response retrieved 2026-10-11 UTC"", ""title"": ""Gene Ontology dTDP-rhamnose biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0019305""}, {""id"": ""MetaCyc:DTDPGLUCDEHYDRAT-RXN"", ""source_sha256"": ""fbd2c7dd309a6c940c6601ae10a346fc5287937c25158af2d689aa34f9bbc057"", ""source_version"": ""MetaCyc 22.5; full native XML body retrieved 2026-10-11 UTC"", ""title"": ""Native DTDPGLUCDEHYDRAT-RXN reaction and cross-references"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DTDPGLUCDEHYDRAT-RXN""}, {""id"": ""MetaCyc:DTDPRHAMSYN-PWY"", ""source_sha256"": ""be7f6580697c429251fba8d6a863fa6ee147ae8aa06aac9c18b331e6f39df0b8"", ""source_version"": ""MetaCyc 22.5; full native XML body retrieved 2026-10-11 UTC"", ""title"": ""dTDP-L-rhamnose biosynthesis: complete native four-step boundary"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DTDPRHAMSYN-PWY""}, {""id"": ""RHEA:17222"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-027_94e7563c0c4e	RHEA:16970	BFO:0000050	GO:0019305	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0019305|MetaCyc:DTDPDEHYDRHAMEPIM-RXN|MetaCyc:DTDPRHAMSYN-PWY|RHEA:16970		"[{""reference_id"": ""GO:0019305"", ""source_assertion"": ""GO:0019305 is the non-obsolete biological process for dTDP-rhamnose formation; exact synonyms include dTDP-rhamnose biosynthesis."", ""source_locator"": ""/results/0/id; /results/0/name; /results/0/isObsolete; /results/0/definition; /results/0/synonyms""}, {""reference_id"": ""MetaCyc:DTDPRHAMSYN-PWY"", ""source_assertion"": ""The complete native dTDP-L-rhamnose route lists DTDPDEHYDRHAMEPIM-RXN and selects L2R for this step."", ""source_locator"": ""Pathway[@frameid=\""DTDPRHAMSYN-PWY\""]/reaction-list; reaction-layout[Reaction/@frameid=\""DTDPDEHYDRHAMEPIM-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:DTDPDEHYDRHAMEPIM-RXN"", ""source_assertion"": ""DTDPDEHYDRHAMEPIM-RXN has explicit RHEA 16969 unification cross-reference."", ""source_locator"": ""Reaction[@frameid=\""DTDPDEHYDRHAMEPIM-RXN\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid; dblink-relationship""}, {""reference_id"": ""RHEA:16970"", ""source_assertion"": ""RHEA:16969 explicitly links directionalReaction RHEA:16970; this is the selected biosynthetic member."", ""source_locator"": ""http://rdf.rhea-db.org/16969 rh:directionalReaction http://rdf.rhea-db.org/16970""}]"	"[{""id"": ""GO:0019305"", ""source_sha256"": ""a68a207e9cdf3656ff12299acd94650c879172d7115d4ad9ef1a61684dc70b39"", ""source_version"": ""QuickGO term response retrieved 2026-10-11 UTC"", ""title"": ""Gene Ontology dTDP-rhamnose biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0019305""}, {""id"": ""MetaCyc:DTDPDEHYDRHAMEPIM-RXN"", ""source_sha256"": ""3296e34e93407575e60eb9ae51abf6d065571b685789684937a11de1dc45cb6a"", ""source_version"": ""MetaCyc 22.5; full native XML body retrieved 2026-10-11 UTC"", ""title"": ""Native DTDPDEHYDRHAMEPIM-RXN reaction and cross-references"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DTDPDEHYDRHAMEPIM-RXN""}, {""id"": ""MetaCyc:DTDPRHAMSYN-PWY"", ""source_sha256"": ""be7f6580697c429251fba8d6a863fa6ee147ae8aa06aac9c18b331e6f39df0b8"", ""source_version"": ""MetaCyc 22.5; full native XML body retrieved 2026-10-11 UTC"", ""title"": ""dTDP-L-rhamnose biosynthesis: complete native four-step boundary"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DTDPRHAMSYN-PWY""}, {""id"": ""RHEA:16970"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-beta-L-rhamnose"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-028_ff49ebd6de86	RHEA:21798	BFO:0000050	GO:0019305	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0019305|MetaCyc:DTDPDEHYRHAMREDUCT-RXN|MetaCyc:DTDPRHAMSYN-PWY|RHEA:21798		"[{""reference_id"": ""GO:0019305"", ""source_assertion"": ""GO:0019305 is the non-obsolete biological process for dTDP-rhamnose formation; exact synonyms include dTDP-rhamnose biosynthesis."", ""source_locator"": ""/results/0/id; /results/0/name; /results/0/isObsolete; /results/0/definition; /results/0/synonyms""}, {""reference_id"": ""MetaCyc:DTDPRHAMSYN-PWY"", ""source_assertion"": ""The complete native dTDP-L-rhamnose route lists DTDPDEHYRHAMREDUCT-RXN and selects R2L for this step."", ""source_locator"": ""Pathway[@frameid=\""DTDPRHAMSYN-PWY\""]/reaction-list; reaction-layout[Reaction/@frameid=\""DTDPDEHYRHAMREDUCT-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:DTDPDEHYRHAMREDUCT-RXN"", ""source_assertion"": ""DTDPDEHYRHAMREDUCT-RXN has explicit RHEA 21796 unification cross-reference."", ""source_locator"": ""Reaction[@frameid=\""DTDPDEHYRHAMREDUCT-RXN\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid; dblink-relationship""}, {""reference_id"": ""RHEA:21798"", ""source_assertion"": ""RHEA:21796 explicitly links directionalReaction RHEA:21798; this is the selected biosynthetic member."", ""source_locator"": ""http://rdf.rhea-db.org/21796 rh:directionalReaction http://rdf.rhea-db.org/21798""}]"	"[{""id"": ""GO:0019305"", ""source_sha256"": ""a68a207e9cdf3656ff12299acd94650c879172d7115d4ad9ef1a61684dc70b39"", ""source_version"": ""QuickGO term response retrieved 2026-10-11 UTC"", ""title"": ""Gene Ontology dTDP-rhamnose biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0019305""}, {""id"": ""MetaCyc:DTDPDEHYRHAMREDUCT-RXN"", ""source_sha256"": ""a30532a48a8ec43bc7a43962069211d501de4a6a3e50a0e597552276ce271042"", ""source_version"": ""MetaCyc 22.5; full native XML body retrieved 2026-10-11 UTC"", ""title"": ""Native DTDPDEHYRHAMREDUCT-RXN reaction and cross-references"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DTDPDEHYRHAMREDUCT-RXN""}, {""id"": ""MetaCyc:DTDPRHAMSYN-PWY"", ""source_sha256"": ""be7f6580697c429251fba8d6a863fa6ee147ae8aa06aac9c18b331e6f39df0b8"", ""source_version"": ""MetaCyc 22.5; full native XML body retrieved 2026-10-11 UTC"", ""title"": ""dTDP-L-rhamnose biosynthesis: complete native four-step boundary"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DTDPRHAMSYN-PWY""}, {""id"": ""RHEA:21798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-4-dehydro-beta-L-rhamnose + NADPH + H(+) => dTDP-beta-L-rhamnose + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-029_319024bf588f	RHEA:15226	RO:0002413	RHEA:17222	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DTDPRHAMSYN-PWY|RHEA:15226|RHEA:17222	The shared intermediate connects the complete native pathway in the selected biosynthetic direction.	"[{""reference_id"": ""MetaCyc:DTDPRHAMSYN-PWY"", ""source_assertion"": ""DTDPGLUCDEHYDRAT-RXN explicitly follows DTDPGLUCOSEPP-RXN in the native route."", ""source_locator"": ""Pathway[@frameid=\""DTDPRHAMSYN-PWY\""]/reaction-ordering[Reaction/@frameid=\""DTDPGLUCDEHYDRAT-RXN\""]""}, {""reference_id"": ""RHEA:15226"", ""source_assertion"": ""RHEA:15226 produces CHEBI:57477, the intermediate consumed by the next selected reaction."", ""source_locator"": ""http://rdf.rhea-db.org/15226 rh:products; http://rdf.rhea-db.org/15225_R rh:contains1""}, {""reference_id"": ""RHEA:17222"", ""source_assertion"": ""RHEA:17222 consumes the chemically identical CHEBI:57477."", ""source_locator"": ""http://rdf.rhea-db.org/17222 rh:substrates; http://rdf.rhea-db.org/17221_L rh:contains1""}]"	"[{""id"": ""MetaCyc:DTDPRHAMSYN-PWY"", ""source_sha256"": ""be7f6580697c429251fba8d6a863fa6ee147ae8aa06aac9c18b331e6f39df0b8"", ""source_version"": ""MetaCyc 22.5; full native XML body retrieved 2026-10-11 UTC"", ""title"": ""dTDP-L-rhamnose biosynthesis: complete native four-step boundary"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DTDPRHAMSYN-PWY""}, {""id"": ""RHEA:15226"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTTP + alpha-D-glucose 1-phosphate + H(+) => dTDP-alpha-D-glucose + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:17222"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-030_281010a31738	RHEA:17222	RO:0002413	RHEA:16970	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DTDPRHAMSYN-PWY|RHEA:16970|RHEA:17222	The shared intermediate connects the complete native pathway in the selected biosynthetic direction.	"[{""reference_id"": ""MetaCyc:DTDPRHAMSYN-PWY"", ""source_assertion"": ""DTDPDEHYDRHAMEPIM-RXN explicitly follows DTDPGLUCDEHYDRAT-RXN in the native route."", ""source_locator"": ""Pathway[@frameid=\""DTDPRHAMSYN-PWY\""]/reaction-ordering[Reaction/@frameid=\""DTDPDEHYDRHAMEPIM-RXN\""]""}, {""reference_id"": ""RHEA:17222"", ""source_assertion"": ""RHEA:17222 produces CHEBI:57649, the intermediate consumed by the next selected reaction."", ""source_locator"": ""http://rdf.rhea-db.org/17222 rh:products; http://rdf.rhea-db.org/17221_R rh:contains1""}, {""reference_id"": ""RHEA:16970"", ""source_assertion"": ""RHEA:16970 consumes the chemically identical CHEBI:57649."", ""source_locator"": ""http://rdf.rhea-db.org/16970 rh:substrates; http://rdf.rhea-db.org/16969_L rh:contains1""}]"	"[{""id"": ""MetaCyc:DTDPRHAMSYN-PWY"", ""source_sha256"": ""be7f6580697c429251fba8d6a863fa6ee147ae8aa06aac9c18b331e6f39df0b8"", ""source_version"": ""MetaCyc 22.5; full native XML body retrieved 2026-10-11 UTC"", ""title"": ""dTDP-L-rhamnose biosynthesis: complete native four-step boundary"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DTDPRHAMSYN-PWY""}, {""id"": ""RHEA:16970"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-beta-L-rhamnose"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:17222"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0019305_rhamnose-edge-031_347568e86728	RHEA:16970	RO:0002413	RHEA:21798	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DTDPRHAMSYN-PWY|PMID:10217500|RHEA:16970|RHEA:21798	The intermediate is free rather than obligatorily channeled through a joint RmlC-RmlD complex. The native monomer prose asserting unreleased intermediate is not adopted; the cited primary paper demonstrates release.	"[{""reference_id"": ""MetaCyc:DTDPRHAMSYN-PWY"", ""source_assertion"": ""DTDPDEHYRHAMREDUCT-RXN explicitly follows DTDPDEHYDRHAMEPIM-RXN in the native route."", ""source_locator"": ""Pathway[@frameid=\""DTDPRHAMSYN-PWY\""]/reaction-ordering[Reaction/@frameid=\""DTDPDEHYRHAMREDUCT-RXN\""]""}, {""reference_id"": ""RHEA:16970"", ""source_assertion"": ""RHEA:16970 produces CHEBI:62830, the intermediate consumed by the next selected reaction."", ""source_locator"": ""http://rdf.rhea-db.org/16970 rh:products; http://rdf.rhea-db.org/16969_R rh:contains1""}, {""reference_id"": ""RHEA:21798"", ""source_assertion"": ""RHEA:21798 consumes the chemically identical CHEBI:62830."", ""source_locator"": ""http://rdf.rhea-db.org/21798 rh:substrates; http://rdf.rhea-db.org/21796_R rh:contains1""}, {""reference_id"": ""PMID:10217500"", ""source_assertion"": ""K-12 extract experiments show free 4-keto-rhamnose; the Discussion concludes epimerase can function independently of reductase, while not excluding possible in vivo interaction."", ""source_locator"": ""PDF pp.664,667-669; Fig.3 caption; Discussion final paragraphs""}]"	"[{""id"": ""MetaCyc:DTDPRHAMSYN-PWY"", ""source_sha256"": ""be7f6580697c429251fba8d6a863fa6ee147ae8aa06aac9c18b331e6f39df0b8"", ""source_version"": ""MetaCyc 22.5; full native XML body retrieved 2026-10-11 UTC"", ""title"": ""dTDP-L-rhamnose biosynthesis: complete native four-step boundary"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DTDPRHAMSYN-PWY""}, {""id"": ""PMID:10217500"", ""source_sha256"": ""29b2710e332b38917153a118a7799865f765aa3bd097f7389d49fbd961351eef"", ""source_version"": ""Complete primary publisher PDF; pages 663-671; retrieved 2026-10-11 UTC"", ""title"": ""Conversion of dTDP-4-keto-6-deoxyglucose to free dTDP-4-keto-rhamnose by the rmIC gene products of Escherichia coli and Mycobacterium tuberculosis."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/10217500/""}, {""id"": ""RHEA:16970"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-beta-L-rhamnose"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:21798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers the complete compressed RDF source"", ""title"": ""dTDP-4-dehydro-beta-L-rhamnose + NADPH + H(+) => dTDP-beta-L-rhamnose + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-001_19ec9a48a2bf	CHEBI:29991	pathwaymech:consumes	RHEA:23777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23777		"[{""reference_id"": ""RHEA:23777"", ""source_assertion"": ""Rhea lists CHEBI:29991 on the substrates side of RHEA:23777 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23777']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23777"", ""source_version"": ""139"", ""title"": ""Rhea L-aspartate kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/23777""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-002_c393ea8ea3aa	CHEBI:30616	pathwaymech:consumes	RHEA:23777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23777		"[{""reference_id"": ""RHEA:23777"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:23777 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23777']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23777"", ""source_version"": ""139"", ""title"": ""Rhea L-aspartate kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/23777""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-003_16ff35c699b7	RHEA:23777	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23777		"[{""reference_id"": ""RHEA:23777"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:23777 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23777']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23777"", ""source_version"": ""139"", ""title"": ""Rhea L-aspartate kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/23777""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-004_6c3e62b0bb68	RHEA:23777	pathwaymech:produces	CHEBI:57535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23777		"[{""reference_id"": ""RHEA:23777"", ""source_assertion"": ""Rhea lists CHEBI:57535 on the products side of RHEA:23777 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23777']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23777"", ""source_version"": ""139"", ""title"": ""Rhea L-aspartate kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/23777""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-005_8aa78734073a	CHEBI:15378	pathwaymech:consumes	RHEA:24286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24286		"[{""reference_id"": ""RHEA:24286"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:24286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24286']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24286"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic aspartate-semialdehyde dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/24286""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-006_de85c1cdc999	CHEBI:57535	pathwaymech:consumes	RHEA:24286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24286		"[{""reference_id"": ""RHEA:24286"", ""source_assertion"": ""Rhea lists CHEBI:57535 on the substrates side of RHEA:24286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24286']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24286"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic aspartate-semialdehyde dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/24286""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-007_27de96ab07a4	CHEBI:57783	pathwaymech:consumes	RHEA:24286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24286		"[{""reference_id"": ""RHEA:24286"", ""source_assertion"": ""Rhea lists CHEBI:57783 on the substrates side of RHEA:24286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24286']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24286"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic aspartate-semialdehyde dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/24286""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-008_4e76eeeb89e0	RHEA:24286	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24286		"[{""reference_id"": ""RHEA:24286"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:24286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24286']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24286"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic aspartate-semialdehyde dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/24286""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-009_49a08cd698c3	RHEA:24286	pathwaymech:produces	CHEBI:537519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24286		"[{""reference_id"": ""RHEA:24286"", ""source_assertion"": ""Rhea lists CHEBI:537519 on the products side of RHEA:24286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24286']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24286"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic aspartate-semialdehyde dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/24286""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-010_91b4e4a50175	RHEA:24286	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24286		"[{""reference_id"": ""RHEA:24286"", ""source_assertion"": ""Rhea lists CHEBI:58349 on the products side of RHEA:24286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24286']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24286"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic aspartate-semialdehyde dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/24286""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-011_aabff5b647f8	CHEBI:29985	pathwaymech:consumes	RHEA:11162	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11162		"[{""reference_id"": ""RHEA:11162"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the substrates side of RHEA:11162 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11162']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11162"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic diaminobutyrate transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/11162""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-012_74a56644dde1	CHEBI:537519	pathwaymech:consumes	RHEA:11162	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11162		"[{""reference_id"": ""RHEA:11162"", ""source_assertion"": ""Rhea lists CHEBI:537519 on the substrates side of RHEA:11162 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11162']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11162"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic diaminobutyrate transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/11162""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-013_ec2fc44295dd	RHEA:11162	pathwaymech:produces	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11162		"[{""reference_id"": ""RHEA:11162"", ""source_assertion"": ""Rhea lists CHEBI:16810 on the products side of RHEA:11162 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11162']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11162"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic diaminobutyrate transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/11162""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-014_0efe8aed2103	RHEA:11162	pathwaymech:produces	CHEBI:58761	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11162		"[{""reference_id"": ""RHEA:11162"", ""source_assertion"": ""Rhea lists CHEBI:58761 on the products side of RHEA:11162 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11162']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11162"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic diaminobutyrate transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/11162""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-015_f6c4b2780c58	CHEBI:57288	pathwaymech:consumes	RHEA:16902	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16902		"[{""reference_id"": ""RHEA:16902"", ""source_assertion"": ""Rhea lists CHEBI:57288 on the substrates side of RHEA:16902 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16902']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16902"", ""source_version"": ""139"", ""title"": ""Rhea diaminobutanoate acetyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/16902""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-016_b38332646e0c	CHEBI:58761	pathwaymech:consumes	RHEA:16902	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16902		"[{""reference_id"": ""RHEA:16902"", ""source_assertion"": ""Rhea lists CHEBI:58761 on the substrates side of RHEA:16902 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16902']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16902"", ""source_version"": ""139"", ""title"": ""Rhea diaminobutanoate acetyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/16902""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-017_bcc04a7ba970	RHEA:16902	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16902		"[{""reference_id"": ""RHEA:16902"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:16902 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16902']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16902"", ""source_version"": ""139"", ""title"": ""Rhea diaminobutanoate acetyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/16902""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-018_4b3f9a618a37	RHEA:16902	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16902		"[{""reference_id"": ""RHEA:16902"", ""source_assertion"": ""Rhea lists CHEBI:57287 on the products side of RHEA:16902 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16902']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16902"", ""source_version"": ""139"", ""title"": ""Rhea diaminobutanoate acetyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/16902""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-019_d4a128cd8a05	RHEA:16902	pathwaymech:produces	CHEBI:58929	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16902		"[{""reference_id"": ""RHEA:16902"", ""source_assertion"": ""Rhea lists CHEBI:58929 on the products side of RHEA:16902 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16902']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16902"", ""source_version"": ""139"", ""title"": ""Rhea diaminobutanoate acetyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/16902""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-020_273b0f3dc424	CHEBI:58929	pathwaymech:consumes	RHEA:17282	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17282		"[{""reference_id"": ""RHEA:17282"", ""source_assertion"": ""Rhea lists CHEBI:58929 on the substrates side of RHEA:17282 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17282']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17282"", ""source_version"": ""139"", ""title"": ""Rhea L-ectoine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/17282""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-021_b29949aa122e	RHEA:17282	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17282		"[{""reference_id"": ""RHEA:17282"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:17282 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17282']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17282"", ""source_version"": ""139"", ""title"": ""Rhea L-ectoine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/17282""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-022_d2c34c328c0b	RHEA:17282	pathwaymech:produces	CHEBI:58515	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17282		"[{""reference_id"": ""RHEA:17282"", ""source_assertion"": ""Rhea lists CHEBI:58515 on the products side of RHEA:17282 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17282']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17282"", ""source_version"": ""139"", ""title"": ""Rhea L-ectoine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/17282""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-023_529f7136ff43	EC:2.7.2.4	pathwaymech:catalyzes	RHEA:23777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23776		"[{""reference_id"": ""RHEA:23776"", ""source_assertion"": ""Rhea associates EC:2.7.2.4 with the reaction family containing RHEA:23777."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:23776"", ""source_version"": ""139"", ""title"": ""RHEA:23776 authority record"", ""url"": ""https://www.rhea-db.org/rhea/23776""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-024_08f5e825d0b5	EC:1.2.1.11	pathwaymech:catalyzes	RHEA:24286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24284		"[{""reference_id"": ""RHEA:24284"", ""source_assertion"": ""Rhea associates EC:1.2.1.11 with the reaction family containing RHEA:24286."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:24284"", ""source_version"": ""139"", ""title"": ""RHEA:24284 authority record"", ""url"": ""https://www.rhea-db.org/rhea/24284""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-025_16f19cd9ee93	EC:2.6.1.76	pathwaymech:catalyzes	RHEA:11162	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9864317|RHEA:11160		"[{""reference_id"": ""RHEA:11160"", ""source_assertion"": ""Rhea associates EC:2.6.1.76 with the reaction family containing RHEA:11162."", ""source_locator"": ""rh:ec""}, {""quote"": ""conversion of ASA to DABA by transamination with l-glutamate"", ""reference_id"": ""PMID:9864317"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Ono et al., Journal of Bacteriology, 1999"", ""id"": ""PMID:9864317"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9864317/""}, {""id"": ""RHEA:11160"", ""source_version"": ""139"", ""title"": ""RHEA:11160 authority record"", ""url"": ""https://www.rhea-db.org/rhea/11160""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-026_13f73db40dd7	EC:2.3.1.178	pathwaymech:catalyzes	RHEA:16902	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9864317|RHEA:16901		"[{""reference_id"": ""RHEA:16901"", ""source_assertion"": ""Rhea associates EC:2.3.1.178 with the reaction family containing RHEA:16902."", ""source_locator"": ""rh:ec""}, {""quote"": ""DABA acetyltransferase catalyzed acetylation of DABA"", ""reference_id"": ""PMID:9864317"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Ono et al., Journal of Bacteriology, 1999"", ""id"": ""PMID:9864317"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9864317/""}, {""id"": ""RHEA:16901"", ""source_version"": ""139"", ""title"": ""RHEA:16901 authority record"", ""url"": ""https://www.rhea-db.org/rhea/16901""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-027_51dd34c8f84b	EC:4.2.1.108	pathwaymech:catalyzes	RHEA:17282	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9864317|RHEA:17281		"[{""reference_id"": ""RHEA:17281"", ""source_assertion"": ""Rhea associates EC:4.2.1.108 with the reaction family containing RHEA:17282."", ""source_locator"": ""rh:ec""}, {""quote"": ""Ectoine synthase catalyzed circularization of ADABA to ectoine"", ""reference_id"": ""PMID:9864317"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Ono et al., Journal of Bacteriology, 1999"", ""id"": ""PMID:9864317"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9864317/""}, {""id"": ""RHEA:17281"", ""source_version"": ""139"", ""title"": ""RHEA:17281 authority record"", ""url"": ""https://www.rhea-db.org/rhea/17281""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-028_ee3d2c0088a7	RHEA:11162	pathwaymech:precedes	RHEA:16902	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:P101-PWY		"[{""reference_id"": ""MetaCyc:P101-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:11162 before RHEA:16902 in this pathway. Shared intermediate: CHEBI:58761."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:P101-PWY"", ""source_sha256"": ""0bd16f00b21341decc590fe5cb8477d56f538cf73969ee3b87bd74c686cc8733"", ""source_version"": ""22.5"", ""title"": ""MetaCyc ectoine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:P101-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-029_7d4a20fe679f	RHEA:16902	pathwaymech:precedes	RHEA:17282	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:P101-PWY		"[{""reference_id"": ""MetaCyc:P101-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:16902 before RHEA:17282 in this pathway. Shared intermediate: CHEBI:58929."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:P101-PWY"", ""source_sha256"": ""0bd16f00b21341decc590fe5cb8477d56f538cf73969ee3b87bd74c686cc8733"", ""source_version"": ""22.5"", ""title"": ""MetaCyc ectoine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:P101-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-030_8a6b2b119ebf	RHEA:23777	pathwaymech:precedes	RHEA:24286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:P101-PWY		"[{""reference_id"": ""MetaCyc:P101-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:23777 before RHEA:24286 in this pathway. Shared intermediate: CHEBI:57535."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:P101-PWY"", ""source_sha256"": ""0bd16f00b21341decc590fe5cb8477d56f538cf73969ee3b87bd74c686cc8733"", ""source_version"": ""22.5"", ""title"": ""MetaCyc ectoine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:P101-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-031_eaf6ec95866a	RHEA:24286	pathwaymech:precedes	RHEA:11162	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:P101-PWY		"[{""reference_id"": ""MetaCyc:P101-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:24286 before RHEA:11162 in this pathway. Shared intermediate: CHEBI:537519."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:P101-PWY"", ""source_sha256"": ""0bd16f00b21341decc590fe5cb8477d56f538cf73969ee3b87bd74c686cc8733"", ""source_version"": ""22.5"", ""title"": ""MetaCyc ectoine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:P101-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-032_6b77f738017d	UniProtKB:E1V7V7	pathwaymech:enables	RHEA:11162	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:E1V7V7		"[{""reference_id"": ""UniProtKB:E1V7V7"", ""source_assertion"": ""UniProt annotates UniProtKB:E1V7V7 with catalytic activity for the reaction family of RHEA:11162. Annotation evidence: ECO:0000305; organism taxon: NCBITaxon:768066."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:E1V7V7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:E1V7V7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/E1V7V7.json""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-033_f460ed8e5c99	UniProtKB:E1V7V7	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:E1V7V7		"[{""reference_id"": ""UniProtKB:E1V7V7"", ""source_assertion"": ""UniProt locates UniProtKB:E1V7V7 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000250."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:E1V7V7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:E1V7V7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/E1V7V7.json""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-034_496631d01ef3	UniProtKB:E1V7V7	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:E1V7V7		"[{""reference_id"": ""UniProtKB:E1V7V7"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:E1V7V7 (evidence: ECO:0000250). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:E1V7V7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:E1V7V7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/E1V7V7.json""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-035_37dbf722a312	UniProtKB:O52249	pathwaymech:enables	RHEA:16902	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:O52249		"[{""reference_id"": ""UniProtKB:O52249"", ""source_assertion"": ""UniProt annotates UniProtKB:O52249 with catalytic activity for the reaction family of RHEA:16902. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:768066."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:O52249"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:O52249 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/O52249.json""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-036_c52d8d39c5d2	UniProtKB:O52250	pathwaymech:enables	RHEA:11162	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:O52250		"[{""reference_id"": ""UniProtKB:O52250"", ""source_assertion"": ""UniProt annotates UniProtKB:O52250 with catalytic activity for the reaction family of RHEA:11162. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:768066."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:O52250"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:O52250 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/O52250.json""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-037_5455abebd296	UniProtKB:O52250	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:O52250		"[{""reference_id"": ""UniProtKB:O52250"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:O52250 (evidence: ECO:0000269). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:O52250"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:O52250 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/O52250.json""}]"	""
pathwaymech:MetaCyc_P101-PWY_edge-038_d79c160a1d5c	UniProtKB:O52251	pathwaymech:enables	RHEA:17282	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:O52251		"[{""reference_id"": ""UniProtKB:O52251"", ""source_assertion"": ""UniProt annotates UniProtKB:O52251 with catalytic activity for the reaction family of RHEA:17282. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:768066."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:O52251"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:O52251 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/O52251.json""}]"	""
pathwaymech:KEGG_M00008_ed-edge-001_cdfb7ccee3df	KEGG:R02736	BFO:0000050	KEGG:M00008	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00008	Full native module member. Alternative first-position cofactor activity; do not add its flux to the other alternative.	"[{""reference_id"": ""KEGG:M00008"", ""source_assertion"": ""The module has four sequential positions and explicitly includes R02736 at position 1. R02736 and R10907 are alternatives at the first position, not serial reactions."", ""source_locator"": ""ENTRY; NAME; DEFINITION; ORTHOLOGY""}]"	"[{""id"": ""KEGG:M00008"", ""source_sha256"": ""5f1362bca2e9cc0e5442e99f033836580a5ba23ba2bb80c1f3ce12721420de3a"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate"", ""url"": ""https://rest.kegg.jp/get/M00008""}]"	""
pathwaymech:KEGG_M00008_ed-edge-002_fd546aaf33fa	KEGG:R10907	BFO:0000050	KEGG:M00008	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00008|KEGG:R10907	Full native module member. Alternative first-position cofactor activity; do not add its flux to the other alternative.	"[{""reference_id"": ""KEGG:M00008"", ""source_assertion"": ""The module has four sequential positions and explicitly includes R10907 at position 1. R02736 and R10907 are alternatives at the first position, not serial reactions."", ""source_locator"": ""ENTRY; NAME; DEFINITION; ORTHOLOGY""}, {""reference_id"": ""KEGG:R10907"", ""source_assertion"": ""The reaction lists M00004 and M00006 in its MODULE field, but not M00008; this inverse-membership inconsistency is retained. M00008 itself explicitly lists R10907."", ""source_locator"": ""MODULE""}]"	"[{""id"": ""KEGG:M00008"", ""source_sha256"": ""5f1362bca2e9cc0e5442e99f033836580a5ba23ba2bb80c1f3ce12721420de3a"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate"", ""url"": ""https://rest.kegg.jp/get/M00008""}, {""id"": ""KEGG:R10907"", ""source_sha256"": ""347fb45378bd1495dcaa923861090c3f6fd4900d9bbd5fcf8f2312af881b6c00"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""beta-D-glucose-6-phosphate:NAD+ 1-oxidoreductase"", ""url"": ""https://rest.kegg.jp/get/R10907""}]"	""
pathwaymech:KEGG_M00008_ed-edge-003_8c33ccaa4cfa	RHEA:12557	BFO:0000050	KEGG:M00008	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00008|KEGG:R02035|RHEA:12557	Full native module member. No uptake, ATP-generating lower glycolysis or narrower two-step shunt substitution.	"[{""reference_id"": ""KEGG:M00008"", ""source_assertion"": ""The module has four sequential positions and explicitly includes R02035 at position 2. R02736 and R10907 are alternatives at the first position, not serial reactions."", ""source_locator"": ""ENTRY; NAME; DEFINITION; ORTHOLOGY""}, {""reference_id"": ""KEGG:R02035"", ""source_assertion"": ""The native equation has the selected transformation and a cross-reference to bidirectional Rhea 12559; it does not itself specify the directed identifier."", ""source_locator"": ""EQUATION; DBLINKS""}, {""reference_id"": ""RHEA:12557"", ""source_assertion"": ""Rhea master 12556 links bidirectional 12559 and directional 12557; the selected substrates/products orient catabolic module flow."", ""source_locator"": ""http://rdf.rhea-db.org/12556 rh:bidirectionalReaction, rh:directionalReaction; RHEA:12557 rh:substrates, rh:products""}]"	"[{""id"": ""KEGG:M00008"", ""source_sha256"": ""5f1362bca2e9cc0e5442e99f033836580a5ba23ba2bb80c1f3ce12721420de3a"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate"", ""url"": ""https://rest.kegg.jp/get/M00008""}, {""id"": ""KEGG:R02035"", ""source_sha256"": ""9d63bcba0195877a9f28aa6a30c415aa6e2cffc388e408d819ee8ab16a9828dc"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""6-phospho-D-glucono-1,5-lactone lactonohydrolase"", ""url"": ""https://rest.kegg.jp/get/R02035""}, {""id"": ""RHEA:12557"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""6-phospho-D-glucono-1,5-lactone + H2O => 6-phospho-D-gluconate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:KEGG_M00008_ed-edge-004_595385f0eeca	RHEA:17278	BFO:0000050	KEGG:M00008	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00008|KEGG:R02036|RHEA:17278	Full native module member. No uptake, ATP-generating lower glycolysis or narrower two-step shunt substitution.	"[{""reference_id"": ""KEGG:M00008"", ""source_assertion"": ""The module has four sequential positions and explicitly includes R02036 at position 3. R02736 and R10907 are alternatives at the first position, not serial reactions."", ""source_locator"": ""ENTRY; NAME; DEFINITION; ORTHOLOGY""}, {""reference_id"": ""KEGG:R02036"", ""source_assertion"": ""The native equation has the selected transformation and a cross-reference to bidirectional Rhea 17280; it does not itself specify the directed identifier."", ""source_locator"": ""EQUATION; DBLINKS""}, {""reference_id"": ""RHEA:17278"", ""source_assertion"": ""Rhea master 17277 links bidirectional 17280 and directional 17278; the selected substrates/products orient catabolic module flow."", ""source_locator"": ""http://rdf.rhea-db.org/17277 rh:bidirectionalReaction, rh:directionalReaction; RHEA:17278 rh:substrates, rh:products""}]"	"[{""id"": ""KEGG:M00008"", ""source_sha256"": ""5f1362bca2e9cc0e5442e99f033836580a5ba23ba2bb80c1f3ce12721420de3a"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate"", ""url"": ""https://rest.kegg.jp/get/M00008""}, {""id"": ""KEGG:R02036"", ""source_sha256"": ""44ee1d2eebfe070319cdf62bf1ed96632487389f7b30ab9c99068897fa525597"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)"", ""url"": ""https://rest.kegg.jp/get/R02036""}, {""id"": ""RHEA:17278"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""6-phospho-D-gluconate => 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:KEGG_M00008_ed-edge-005_2f851a6bd822	RHEA:17090	BFO:0000050	KEGG:M00008	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00008|KEGG:R05605|RHEA:17090	Full native module member. No uptake, ATP-generating lower glycolysis or narrower two-step shunt substitution.	"[{""reference_id"": ""KEGG:M00008"", ""source_assertion"": ""The module has four sequential positions and explicitly includes R05605 at position 4. R02736 and R10907 are alternatives at the first position, not serial reactions."", ""source_locator"": ""ENTRY; NAME; DEFINITION; ORTHOLOGY""}, {""reference_id"": ""KEGG:R05605"", ""source_assertion"": ""The native equation has the selected transformation and a cross-reference to bidirectional Rhea 17092; it does not itself specify the directed identifier."", ""source_locator"": ""EQUATION; DBLINKS""}, {""reference_id"": ""RHEA:17090"", ""source_assertion"": ""Rhea master 17089 links bidirectional 17092 and directional 17090; the selected substrates/products orient catabolic module flow."", ""source_locator"": ""http://rdf.rhea-db.org/17089 rh:bidirectionalReaction, rh:directionalReaction; RHEA:17090 rh:substrates, rh:products""}]"	"[{""id"": ""KEGG:M00008"", ""source_sha256"": ""5f1362bca2e9cc0e5442e99f033836580a5ba23ba2bb80c1f3ce12721420de3a"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate"", ""url"": ""https://rest.kegg.jp/get/M00008""}, {""id"": ""KEGG:R05605"", ""source_sha256"": ""3bef15e6d2acf4465ed6029d50adc1c5c7511d37002e44dbaca1991a1cd52922"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""2-dehydro-3-deoxy-6-phospho-D-gluconate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)"", ""url"": ""https://rest.kegg.jp/get/R05605""}, {""id"": ""RHEA:17090"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""2-dehydro-3-deoxy-6-phospho-D-gluconate => D-glyceraldehyde 3-phosphate + pyruvate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:KEGG_M00008_ed-edge-006_71319f591d9a	CHEBI:58349	pathwaymech:consumes	KEGG:R02736	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:58349|KEGG:C00006|KEGG:R02736	Coefficient: 1. This is one alternative source-specific beta-anomer equation, normalized to charged participants; exclusive beta enzyme specificity and equal in vivo donor flux are not claimed.	"[{""reference_id"": ""KEGG:R02736"", ""source_assertion"": ""The original beta-specific equation is C01172 + C00006 <=> C01236 + C00005 + C00080. Forward module use is selected; the native equation is reversible."", ""source_locator"": ""EQUATION; DEFINITION""}, {""reference_id"": ""KEGG:C00006"", ""source_assertion"": ""The original compound entry and its ATOM/BOND fields fix the native chemical identity. The selected charged ChEBI form preserves connectivity and stereochemistry with explicit acid-base normalization; no neutral/charged exactMatch is asserted."", ""source_locator"": ""ENTRY; NAME; FORMULA; ATOM; BOND""}, {""reference_id"": ""CHEBI:58349"", ""source_assertion"": ""The issuing structure, formula and charge specify the selected normalized reaction participant. Its protonation is compared with the original KEGG structure; coefficients balance this complete charged equation."", ""source_locator"": ""statements subject=CHEBI:58349; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:58349"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; digest covers entire original uncompressed Semantic SQL database"", ""title"": ""NADP(3-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""KEGG:C00006"", ""source_sha256"": ""da802f593820e0e0af19697fe2d8dd585732f78eab822fac5b24e5d62885fcaf"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""NADP+;\nNADP;\nNicotinamide adenine dinucleotide phosphate;\nbeta-Nicotinamide adenine dinucleotide phosphate;\nTPN;\nTriphosphopyridine nucleotide;\nbeta-NADP+"", ""url"": ""https://rest.kegg.jp/get/C00006""}, {""id"": ""KEGG:R02736"", ""source_sha256"": ""885ed16e1be80bec5dff01f3fa12222ca605e7f86e31b37e7bd201119c021ee7"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""beta-D-glucose-6-phosphate:NADP+ 1-oxoreductase"", ""url"": ""https://rest.kegg.jp/get/R02736""}]"	""
pathwaymech:KEGG_M00008_ed-edge-007_ac6bfef750bb	KEGG:R02736	pathwaymech:produces	CHEBI:57955	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:57955|KEGG:C01236|KEGG:R02736	Coefficient: 1. This is one alternative source-specific beta-anomer equation, normalized to charged participants; exclusive beta enzyme specificity and equal in vivo donor flux are not claimed.	"[{""reference_id"": ""KEGG:R02736"", ""source_assertion"": ""The original beta-specific equation is C01172 + C00006 <=> C01236 + C00005 + C00080. Forward module use is selected; the native equation is reversible."", ""source_locator"": ""EQUATION; DEFINITION""}, {""reference_id"": ""KEGG:C01236"", ""source_assertion"": ""The original compound entry and its ATOM/BOND fields fix the native chemical identity. The selected charged ChEBI form preserves connectivity and stereochemistry with explicit acid-base normalization; no neutral/charged exactMatch is asserted."", ""source_locator"": ""ENTRY; NAME; FORMULA; ATOM; BOND""}, {""reference_id"": ""CHEBI:57955"", ""source_assertion"": ""The issuing structure, formula and charge specify the selected normalized reaction participant. Its protonation is compared with the original KEGG structure; coefficients balance this complete charged equation."", ""source_locator"": ""statements subject=CHEBI:57955; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:57955"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; digest covers entire original uncompressed Semantic SQL database"", ""title"": ""6-O-phosphonato-D-glucono-1,5-lactone(2-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""KEGG:C01236"", ""source_sha256"": ""bbe6627658daa95e84ea241d9d38cafd5dee360294cba091bf709b323f2b574e"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""D-Glucono-1,5-lactone 6-phosphate;\n6-Phospho-D-glucono-1,5-lactone"", ""url"": ""https://rest.kegg.jp/get/C01236""}, {""id"": ""KEGG:R02736"", ""source_sha256"": ""885ed16e1be80bec5dff01f3fa12222ca605e7f86e31b37e7bd201119c021ee7"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""beta-D-glucose-6-phosphate:NADP+ 1-oxoreductase"", ""url"": ""https://rest.kegg.jp/get/R02736""}]"	""
pathwaymech:KEGG_M00008_ed-edge-008_081655b875e3	KEGG:R02736	pathwaymech:produces	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:57783|KEGG:C00005|KEGG:R02736	Coefficient: 1. This is one alternative source-specific beta-anomer equation, normalized to charged participants; exclusive beta enzyme specificity and equal in vivo donor flux are not claimed.	"[{""reference_id"": ""KEGG:R02736"", ""source_assertion"": ""The original beta-specific equation is C01172 + C00006 <=> C01236 + C00005 + C00080. Forward module use is selected; the native equation is reversible."", ""source_locator"": ""EQUATION; DEFINITION""}, {""reference_id"": ""KEGG:C00005"", ""source_assertion"": ""The original compound entry and its ATOM/BOND fields fix the native chemical identity. The selected charged ChEBI form preserves connectivity and stereochemistry with explicit acid-base normalization; no neutral/charged exactMatch is asserted."", ""source_locator"": ""ENTRY; NAME; FORMULA; ATOM; BOND""}, {""reference_id"": ""CHEBI:57783"", ""source_assertion"": ""The issuing structure, formula and charge specify the selected normalized reaction participant. Its protonation is compared with the original KEGG structure; coefficients balance this complete charged equation."", ""source_locator"": ""statements subject=CHEBI:57783; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:57783"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; digest covers entire original uncompressed Semantic SQL database"", ""title"": ""NADPH(4-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""KEGG:C00005"", ""source_sha256"": ""2540b7508946f4921609cc9733d9a1fd92071be0cb698df6544feaf7a1dd4149"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""NADPH;\nTPNH;\nReduced nicotinamide adenine dinucleotide phosphate"", ""url"": ""https://rest.kegg.jp/get/C00005""}, {""id"": ""KEGG:R02736"", ""source_sha256"": ""885ed16e1be80bec5dff01f3fa12222ca605e7f86e31b37e7bd201119c021ee7"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""beta-D-glucose-6-phosphate:NADP+ 1-oxoreductase"", ""url"": ""https://rest.kegg.jp/get/R02736""}]"	""
pathwaymech:KEGG_M00008_ed-edge-009_c8d12310bf98	KEGG:R02736	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|KEGG:C00080|KEGG:R02736	Coefficient: 1. This is one alternative source-specific beta-anomer equation, normalized to charged participants; exclusive beta enzyme specificity and equal in vivo donor flux are not claimed.	"[{""reference_id"": ""KEGG:R02736"", ""source_assertion"": ""The original beta-specific equation is C01172 + C00006 <=> C01236 + C00005 + C00080. Forward module use is selected; the native equation is reversible."", ""source_locator"": ""EQUATION; DEFINITION""}, {""reference_id"": ""KEGG:C00080"", ""source_assertion"": ""The original compound entry and its ATOM/BOND fields fix the native chemical identity. The selected charged ChEBI form preserves connectivity and stereochemistry with explicit acid-base normalization; no neutral/charged exactMatch is asserted."", ""source_locator"": ""ENTRY; NAME; FORMULA; ATOM; BOND""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""The issuing structure, formula and charge specify the selected normalized reaction participant. Its protonation is compared with the original KEGG structure; coefficients balance this complete charged equation."", ""source_locator"": ""statements subject=CHEBI:15378; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; digest covers entire original uncompressed Semantic SQL database"", ""title"": ""hydron"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""KEGG:C00080"", ""source_sha256"": ""35296b0e31f9dc8d369626fa363da904ac94447eb6e1375ff369c402a7691b3b"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""H+;\nHydron"", ""url"": ""https://rest.kegg.jp/get/C00080""}, {""id"": ""KEGG:R02736"", ""source_sha256"": ""885ed16e1be80bec5dff01f3fa12222ca605e7f86e31b37e7bd201119c021ee7"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""beta-D-glucose-6-phosphate:NADP+ 1-oxoreductase"", ""url"": ""https://rest.kegg.jp/get/R02736""}]"	""
pathwaymech:KEGG_M00008_ed-edge-010_36c626f1e1ee	CHEBI:58247	pathwaymech:consumes	KEGG:R02736	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:58247|KEGG:C01172|KEGG:R02736	Coefficient: 1. This is one alternative source-specific beta-anomer equation, normalized to charged participants; exclusive beta enzyme specificity and equal in vivo donor flux are not claimed.	"[{""reference_id"": ""KEGG:R02736"", ""source_assertion"": ""The original beta-specific equation is C01172 + C00006 <=> C01236 + C00005 + C00080. Forward module use is selected; the native equation is reversible."", ""source_locator"": ""EQUATION; DEFINITION""}, {""reference_id"": ""KEGG:C01172"", ""source_assertion"": ""The original compound entry and its ATOM/BOND fields fix the native chemical identity. The selected charged ChEBI form preserves connectivity and stereochemistry with explicit acid-base normalization; no neutral/charged exactMatch is asserted."", ""source_locator"": ""ENTRY; NAME; FORMULA; ATOM; BOND""}, {""reference_id"": ""CHEBI:58247"", ""source_assertion"": ""The issuing structure, formula and charge specify the selected normalized reaction participant. Its protonation is compared with the original KEGG structure; coefficients balance this complete charged equation."", ""source_locator"": ""statements subject=CHEBI:58247; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:58247"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; digest covers entire original uncompressed Semantic SQL database"", ""title"": ""beta-D-glucose 6-phosphate(2-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""KEGG:C01172"", ""source_sha256"": ""8f3a3388e745ad790e7dbb093ef03c0c1d59c5b3f95c964870fb1d5c0c2a5d0a"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""beta-D-Glucose 6-phosphate"", ""url"": ""https://rest.kegg.jp/get/C01172""}, {""id"": ""KEGG:R02736"", ""source_sha256"": ""885ed16e1be80bec5dff01f3fa12222ca605e7f86e31b37e7bd201119c021ee7"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""beta-D-glucose-6-phosphate:NADP+ 1-oxoreductase"", ""url"": ""https://rest.kegg.jp/get/R02736""}]"	""
pathwaymech:KEGG_M00008_ed-edge-011_96286e2ca255	KEGG:R10907	pathwaymech:produces	CHEBI:57955	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:57955|KEGG:C01236|KEGG:R10907	Coefficient: 1. This is one alternative source-specific beta-anomer equation, normalized to charged participants; exclusive beta enzyme specificity and equal in vivo donor flux are not claimed.	"[{""reference_id"": ""KEGG:R10907"", ""source_assertion"": ""The original beta-specific equation is C01172 + C00003 <=> C01236 + C00004 + C00080. Forward module use is selected; the native equation is reversible."", ""source_locator"": ""EQUATION; DEFINITION""}, {""reference_id"": ""KEGG:C01236"", ""source_assertion"": ""The original compound entry and its ATOM/BOND fields fix the native chemical identity. The selected charged ChEBI form preserves connectivity and stereochemistry with explicit acid-base normalization; no neutral/charged exactMatch is asserted."", ""source_locator"": ""ENTRY; NAME; FORMULA; ATOM; BOND""}, {""reference_id"": ""CHEBI:57955"", ""source_assertion"": ""The issuing structure, formula and charge specify the selected normalized reaction participant. Its protonation is compared with the original KEGG structure; coefficients balance this complete charged equation."", ""source_locator"": ""statements subject=CHEBI:57955; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:57955"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; digest covers entire original uncompressed Semantic SQL database"", ""title"": ""6-O-phosphonato-D-glucono-1,5-lactone(2-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""KEGG:C01236"", ""source_sha256"": ""bbe6627658daa95e84ea241d9d38cafd5dee360294cba091bf709b323f2b574e"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""D-Glucono-1,5-lactone 6-phosphate;\n6-Phospho-D-glucono-1,5-lactone"", ""url"": ""https://rest.kegg.jp/get/C01236""}, {""id"": ""KEGG:R10907"", ""source_sha256"": ""347fb45378bd1495dcaa923861090c3f6fd4900d9bbd5fcf8f2312af881b6c00"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""beta-D-glucose-6-phosphate:NAD+ 1-oxidoreductase"", ""url"": ""https://rest.kegg.jp/get/R10907""}]"	""
pathwaymech:KEGG_M00008_ed-edge-012_7a577b22e47a	KEGG:R10907	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|KEGG:C00080|KEGG:R10907	Coefficient: 1. This is one alternative source-specific beta-anomer equation, normalized to charged participants; exclusive beta enzyme specificity and equal in vivo donor flux are not claimed.	"[{""reference_id"": ""KEGG:R10907"", ""source_assertion"": ""The original beta-specific equation is C01172 + C00003 <=> C01236 + C00004 + C00080. Forward module use is selected; the native equation is reversible."", ""source_locator"": ""EQUATION; DEFINITION""}, {""reference_id"": ""KEGG:C00080"", ""source_assertion"": ""The original compound entry and its ATOM/BOND fields fix the native chemical identity. The selected charged ChEBI form preserves connectivity and stereochemistry with explicit acid-base normalization; no neutral/charged exactMatch is asserted."", ""source_locator"": ""ENTRY; NAME; FORMULA; ATOM; BOND""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""The issuing structure, formula and charge specify the selected normalized reaction participant. Its protonation is compared with the original KEGG structure; coefficients balance this complete charged equation."", ""source_locator"": ""statements subject=CHEBI:15378; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; digest covers entire original uncompressed Semantic SQL database"", ""title"": ""hydron"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""KEGG:C00080"", ""source_sha256"": ""35296b0e31f9dc8d369626fa363da904ac94447eb6e1375ff369c402a7691b3b"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""H+;\nHydron"", ""url"": ""https://rest.kegg.jp/get/C00080""}, {""id"": ""KEGG:R10907"", ""source_sha256"": ""347fb45378bd1495dcaa923861090c3f6fd4900d9bbd5fcf8f2312af881b6c00"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""beta-D-glucose-6-phosphate:NAD+ 1-oxidoreductase"", ""url"": ""https://rest.kegg.jp/get/R10907""}]"	""
pathwaymech:KEGG_M00008_ed-edge-013_a69be164efa6	CHEBI:58247	pathwaymech:consumes	KEGG:R10907	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:58247|KEGG:C01172|KEGG:R10907	Coefficient: 1. This is one alternative source-specific beta-anomer equation, normalized to charged participants; exclusive beta enzyme specificity and equal in vivo donor flux are not claimed.	"[{""reference_id"": ""KEGG:R10907"", ""source_assertion"": ""The original beta-specific equation is C01172 + C00003 <=> C01236 + C00004 + C00080. Forward module use is selected; the native equation is reversible."", ""source_locator"": ""EQUATION; DEFINITION""}, {""reference_id"": ""KEGG:C01172"", ""source_assertion"": ""The original compound entry and its ATOM/BOND fields fix the native chemical identity. The selected charged ChEBI form preserves connectivity and stereochemistry with explicit acid-base normalization; no neutral/charged exactMatch is asserted."", ""source_locator"": ""ENTRY; NAME; FORMULA; ATOM; BOND""}, {""reference_id"": ""CHEBI:58247"", ""source_assertion"": ""The issuing structure, formula and charge specify the selected normalized reaction participant. Its protonation is compared with the original KEGG structure; coefficients balance this complete charged equation."", ""source_locator"": ""statements subject=CHEBI:58247; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:58247"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; digest covers entire original uncompressed Semantic SQL database"", ""title"": ""beta-D-glucose 6-phosphate(2-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""KEGG:C01172"", ""source_sha256"": ""8f3a3388e745ad790e7dbb093ef03c0c1d59c5b3f95c964870fb1d5c0c2a5d0a"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""beta-D-Glucose 6-phosphate"", ""url"": ""https://rest.kegg.jp/get/C01172""}, {""id"": ""KEGG:R10907"", ""source_sha256"": ""347fb45378bd1495dcaa923861090c3f6fd4900d9bbd5fcf8f2312af881b6c00"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""beta-D-glucose-6-phosphate:NAD+ 1-oxidoreductase"", ""url"": ""https://rest.kegg.jp/get/R10907""}]"	""
pathwaymech:KEGG_M00008_ed-edge-014_af04d86d27f9	CHEBI:57540	pathwaymech:consumes	KEGG:R10907	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:57540|KEGG:C00003|KEGG:R10907	Coefficient: 1. This is one alternative source-specific beta-anomer equation, normalized to charged participants; exclusive beta enzyme specificity and equal in vivo donor flux are not claimed.	"[{""reference_id"": ""KEGG:R10907"", ""source_assertion"": ""The original beta-specific equation is C01172 + C00003 <=> C01236 + C00004 + C00080. Forward module use is selected; the native equation is reversible."", ""source_locator"": ""EQUATION; DEFINITION""}, {""reference_id"": ""KEGG:C00003"", ""source_assertion"": ""The original compound entry and its ATOM/BOND fields fix the native chemical identity. The selected charged ChEBI form preserves connectivity and stereochemistry with explicit acid-base normalization; no neutral/charged exactMatch is asserted."", ""source_locator"": ""ENTRY; NAME; FORMULA; ATOM; BOND""}, {""reference_id"": ""CHEBI:57540"", ""source_assertion"": ""The issuing structure, formula and charge specify the selected normalized reaction participant. Its protonation is compared with the original KEGG structure; coefficients balance this complete charged equation."", ""source_locator"": ""statements subject=CHEBI:57540; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:57540"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; digest covers entire original uncompressed Semantic SQL database"", ""title"": ""NAD(1-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""KEGG:C00003"", ""source_sha256"": ""91a8b43458597aafaf483b0086ada4d0d3be998237ea594bba8b0e877739bf49"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""NAD+;\nNAD;\nNicotinamide adenine dinucleotide;\nDPN;\nDiphosphopyridine nucleotide;\nNadide;\nbeta-NAD+"", ""url"": ""https://rest.kegg.jp/get/C00003""}, {""id"": ""KEGG:R10907"", ""source_sha256"": ""347fb45378bd1495dcaa923861090c3f6fd4900d9bbd5fcf8f2312af881b6c00"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""beta-D-glucose-6-phosphate:NAD+ 1-oxidoreductase"", ""url"": ""https://rest.kegg.jp/get/R10907""}]"	""
pathwaymech:KEGG_M00008_ed-edge-015_dfe911941c52	KEGG:R10907	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:57945|KEGG:C00004|KEGG:R10907	Coefficient: 1. This is one alternative source-specific beta-anomer equation, normalized to charged participants; exclusive beta enzyme specificity and equal in vivo donor flux are not claimed.	"[{""reference_id"": ""KEGG:R10907"", ""source_assertion"": ""The original beta-specific equation is C01172 + C00003 <=> C01236 + C00004 + C00080. Forward module use is selected; the native equation is reversible."", ""source_locator"": ""EQUATION; DEFINITION""}, {""reference_id"": ""KEGG:C00004"", ""source_assertion"": ""The original compound entry and its ATOM/BOND fields fix the native chemical identity. The selected charged ChEBI form preserves connectivity and stereochemistry with explicit acid-base normalization; no neutral/charged exactMatch is asserted."", ""source_locator"": ""ENTRY; NAME; FORMULA; ATOM; BOND""}, {""reference_id"": ""CHEBI:57945"", ""source_assertion"": ""The issuing structure, formula and charge specify the selected normalized reaction participant. Its protonation is compared with the original KEGG structure; coefficients balance this complete charged equation."", ""source_locator"": ""statements subject=CHEBI:57945; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:57945"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; digest covers entire original uncompressed Semantic SQL database"", ""title"": ""NADH(2-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""KEGG:C00004"", ""source_sha256"": ""c3feab3217c37b5430c518de758c9cfe836bc27891d377b5934b79348f631191"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""NADH;\nDPNH;\nReduced nicotinamide adenine dinucleotide"", ""url"": ""https://rest.kegg.jp/get/C00004""}, {""id"": ""KEGG:R10907"", ""source_sha256"": ""347fb45378bd1495dcaa923861090c3f6fd4900d9bbd5fcf8f2312af881b6c00"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""beta-D-glucose-6-phosphate:NAD+ 1-oxidoreductase"", ""url"": ""https://rest.kegg.jp/get/R10907""}]"	""
pathwaymech:KEGG_M00008_ed-edge-016_df6ca4244a0d	CHEBI:57955	pathwaymech:consumes	RHEA:12557	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12557	Coefficient: 1. Exact directed Rhea participant in the complete module.	"[{""reference_id"": ""RHEA:12557"", ""source_assertion"": ""The original directional substrates chain contains CHEBI:57955 with coefficient 1. The formula and charge belong to the linked native compound, not an inferred label mapping."", ""source_locator"": ""RHEA:12557 rh:substrates -> http://rdf.rhea-db.org/12556_L rh:contains1 -> http://rdf.rhea-db.org/Participant_12556_compound_3399 rh:compound -> http://rdf.rhea-db.org/Compound_3399 rh:accession/formula/charge""}]"	"[{""id"": ""RHEA:12557"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""6-phospho-D-glucono-1,5-lactone + H2O => 6-phospho-D-gluconate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:KEGG_M00008_ed-edge-017_e10a1544477c	CHEBI:15377	pathwaymech:consumes	RHEA:12557	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12557	Coefficient: 1. Exact directed Rhea participant in the complete module.	"[{""reference_id"": ""RHEA:12557"", ""source_assertion"": ""The original directional substrates chain contains CHEBI:15377 with coefficient 1. The formula and charge belong to the linked native compound, not an inferred label mapping."", ""source_locator"": ""RHEA:12557 rh:substrates -> http://rdf.rhea-db.org/12556_L rh:contains1 -> http://rdf.rhea-db.org/Participant_12556_compound_1283 rh:compound -> http://rdf.rhea-db.org/Compound_1283 rh:accession/formula/charge""}]"	"[{""id"": ""RHEA:12557"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""6-phospho-D-glucono-1,5-lactone + H2O => 6-phospho-D-gluconate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:KEGG_M00008_ed-edge-018_d24e8352bbeb	RHEA:12557	pathwaymech:produces	CHEBI:58759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12557	Coefficient: 1. Exact directed Rhea participant in the complete module.	"[{""reference_id"": ""RHEA:12557"", ""source_assertion"": ""The original directional products chain contains CHEBI:58759 with coefficient 1. The formula and charge belong to the linked native compound, not an inferred label mapping."", ""source_locator"": ""RHEA:12557 rh:products -> http://rdf.rhea-db.org/12556_R rh:contains1 -> http://rdf.rhea-db.org/Participant_12556_compound_4577 rh:compound -> http://rdf.rhea-db.org/Compound_4577 rh:accession/formula/charge""}]"	"[{""id"": ""RHEA:12557"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""6-phospho-D-glucono-1,5-lactone + H2O => 6-phospho-D-gluconate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:KEGG_M00008_ed-edge-019_bdb3dfa211ba	RHEA:12557	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12557	Coefficient: 1. Exact directed Rhea participant in the complete module.	"[{""reference_id"": ""RHEA:12557"", ""source_assertion"": ""The original directional products chain contains CHEBI:15378 with coefficient 1. The formula and charge belong to the linked native compound, not an inferred label mapping."", ""source_locator"": ""RHEA:12557 rh:products -> http://rdf.rhea-db.org/12556_R rh:contains1 -> http://rdf.rhea-db.org/Participant_12556_compound_3249 rh:compound -> http://rdf.rhea-db.org/Compound_3249 rh:accession/formula/charge""}]"	"[{""id"": ""RHEA:12557"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""6-phospho-D-glucono-1,5-lactone + H2O => 6-phospho-D-gluconate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:KEGG_M00008_ed-edge-020_8c93c95d4130	CHEBI:58759	pathwaymech:consumes	RHEA:17278	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17278	Coefficient: 1. Exact directed Rhea participant in the complete module.	"[{""reference_id"": ""RHEA:17278"", ""source_assertion"": ""The original directional substrates chain contains CHEBI:58759 with coefficient 1. The formula and charge belong to the linked native compound, not an inferred label mapping."", ""source_locator"": ""RHEA:17278 rh:substrates -> http://rdf.rhea-db.org/17277_L rh:contains1 -> http://rdf.rhea-db.org/Participant_17277_compound_4577 rh:compound -> http://rdf.rhea-db.org/Compound_4577 rh:accession/formula/charge""}]"	"[{""id"": ""RHEA:17278"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""6-phospho-D-gluconate => 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:KEGG_M00008_ed-edge-021_834735b275ca	RHEA:17278	pathwaymech:produces	CHEBI:57569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17278	Coefficient: 1. Exact directed Rhea participant in the complete module.	"[{""reference_id"": ""RHEA:17278"", ""source_assertion"": ""The original directional products chain contains CHEBI:57569 with coefficient 1. The formula and charge belong to the linked native compound, not an inferred label mapping."", ""source_locator"": ""RHEA:17278 rh:products -> http://rdf.rhea-db.org/17277_R rh:contains1 -> http://rdf.rhea-db.org/Participant_17277_compound_5038 rh:compound -> http://rdf.rhea-db.org/Compound_5038 rh:accession/formula/charge""}]"	"[{""id"": ""RHEA:17278"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""6-phospho-D-gluconate => 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:KEGG_M00008_ed-edge-022_e827d14e5fc5	RHEA:17278	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17278	Coefficient: 1. Exact directed Rhea participant in the complete module.	"[{""reference_id"": ""RHEA:17278"", ""source_assertion"": ""The original directional products chain contains CHEBI:15377 with coefficient 1. The formula and charge belong to the linked native compound, not an inferred label mapping."", ""source_locator"": ""RHEA:17278 rh:products -> http://rdf.rhea-db.org/17277_R rh:contains1 -> http://rdf.rhea-db.org/Participant_17277_compound_1283 rh:compound -> http://rdf.rhea-db.org/Compound_1283 rh:accession/formula/charge""}]"	"[{""id"": ""RHEA:17278"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""6-phospho-D-gluconate => 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:KEGG_M00008_ed-edge-023_eb85b7be07a3	CHEBI:57569	pathwaymech:consumes	RHEA:17090	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17090	Coefficient: 1. Exact directed Rhea participant in the complete module.	"[{""reference_id"": ""RHEA:17090"", ""source_assertion"": ""The original directional substrates chain contains CHEBI:57569 with coefficient 1. The formula and charge belong to the linked native compound, not an inferred label mapping."", ""source_locator"": ""RHEA:17090 rh:substrates -> http://rdf.rhea-db.org/17089_L rh:contains1 -> http://rdf.rhea-db.org/Participant_17089_compound_5038 rh:compound -> http://rdf.rhea-db.org/Compound_5038 rh:accession/formula/charge""}]"	"[{""id"": ""RHEA:17090"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""2-dehydro-3-deoxy-6-phospho-D-gluconate => D-glyceraldehyde 3-phosphate + pyruvate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:KEGG_M00008_ed-edge-024_43caeaf4f451	RHEA:17090	pathwaymech:produces	CHEBI:59776	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17090	Coefficient: 1. Exact directed Rhea participant in the complete module.	"[{""reference_id"": ""RHEA:17090"", ""source_assertion"": ""The original directional products chain contains CHEBI:59776 with coefficient 1. The formula and charge belong to the linked native compound, not an inferred label mapping."", ""source_locator"": ""RHEA:17090 rh:products -> http://rdf.rhea-db.org/17089_R rh:contains1 -> http://rdf.rhea-db.org/Participant_17089_compound_6062 rh:compound -> http://rdf.rhea-db.org/Compound_6062 rh:accession/formula/charge""}]"	"[{""id"": ""RHEA:17090"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""2-dehydro-3-deoxy-6-phospho-D-gluconate => D-glyceraldehyde 3-phosphate + pyruvate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:KEGG_M00008_ed-edge-025_e79f274fdcbf	RHEA:17090	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17090	Coefficient: 1. Exact directed Rhea participant in the complete module.	"[{""reference_id"": ""RHEA:17090"", ""source_assertion"": ""The original directional products chain contains CHEBI:15361 with coefficient 1. The formula and charge belong to the linked native compound, not an inferred label mapping."", ""source_locator"": ""RHEA:17090 rh:products -> http://rdf.rhea-db.org/17089_R rh:contains1 -> http://rdf.rhea-db.org/Participant_17089_compound_3719 rh:compound -> http://rdf.rhea-db.org/Compound_3719 rh:accession/formula/charge""}]"	"[{""id"": ""RHEA:17090"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""2-dehydro-3-deoxy-6-phospho-D-gluconate => D-glyceraldehyde 3-phosphate + pyruvate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:KEGG_M00008_ed-edge-026_2d58e129fa0f	UniProtKB:P0AC53	pathwaymech:enables	KEGG:R02736	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1371/journal.pone.0152403.s002|KEGG:R02736|PMID:22519976|PMID:27010804|UniProtKB:P0AC53	Qualified current Zwf gene-product/activity attribution; both cofactor capacities are supported for modified E. coli preparations. Source beta specificity is curated, not experimentally exclusive. No isolated monomer sufficiency, exact historical construct equality or measured NAD-dependent in vivo ED flux is asserted.	"[{""reference_id"": ""UniProtKB:P0AC53"", ""source_assertion"": ""The K-12 zwf/b1852 entry has 491 residues and a generic glucose-6-phosphate/NADP catalytic annotation (ECO:0000255/HAMAP). This is not independent proof of exclusive beta use or of the NAD alternative."", ""source_locator"": ""/primaryAccession; /genes; /organism; /sequence; /comments/2""}, {""reference_id"": ""PMID:22519976"", ""source_assertion"": ""The purified modified E. coli preparation oxidized glucose 6-phosphate with NADP and with NAD, with markedly different affinities. The thrombin-cleaved construct retains twelve extra N-terminal residues. No exclusive-anomer assay or in vivo ED donor partition is established."", ""source_locator"": ""Results: NADP and NAD as co-substrates, Table 1; Experimental procedures: Purification; Discussion, paragraph on twelve extra N-terminal residues""}, {""reference_id"": ""PMID:27010804"", ""source_assertion"": ""The 2016 study retains a wild-type dual-cofactor comparator and engineered mutants. Its TEV construct is expected to retain Gly-His. These are preparation-specific observations, not exact equality to the current native sequence."", ""source_locator"": ""//sec[@id=\""sec005\""]/p | //table-wrap[@id=\""pone.0152403.t001\""]""}, {""reference_id"": ""DOI:10.1371/journal.pone.0152403.s002"", ""source_assertion"": ""S1 Table identifies Escherichia coli P0AC53 among sequences analyzed. This is an accession bridge for sequence analysis, not a complete kinetic construct sequence proof."", ""source_locator"": ""xl/worksheets/sheet1.xml row 9, decoded with xl/sharedStrings.xml""}, {""reference_id"": ""KEGG:R02736"", ""source_assertion"": ""KEGG supplies the beta-specific reaction convention. Applying the enzyme activity to this exact anomer-specific source equation is a qualified annotation-level inference, not direct exclusive-anomer characterization."", ""source_locator"": ""DEFINITION; EQUATION""}]"	"[{""id"": ""DOI:10.1371/journal.pone.0152403.s002"", ""source_sha256"": ""238d3554e2968b2251a43c3bfd5700691ae6928c2f835a112d163d49437ab1e5"", ""source_version"": ""Original supplementary workbook; accession row establishes sequence-analysis scope only"", ""title"": ""S1 Table. Accession numbers of bacterial G6PDHs"", ""url"": ""https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152403.s002&type=supplementary""}, {""id"": ""KEGG:R02736"", ""source_sha256"": ""885ed16e1be80bec5dff01f3fa12222ca605e7f86e31b37e7bd201119c021ee7"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""beta-D-glucose-6-phosphate:NADP+ 1-oxoreductase"", ""url"": ""https://rest.kegg.jp/get/R02736""}, {""id"": ""PMID:22519976"", ""source_version"": ""Full official main article inspected through web on 2026-10-11; local HTTP403 body is not full text; no local article digest claimed"", ""title"": ""The cofactor preference of glucose-6-phosphate dehydrogenase from Escherichia coli– modeling the physiological production of reduced cofactors"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2012.08610.x""}, {""id"": ""PMID:27010804"", ""source_sha256"": ""9435e6924beaed5f2a67c890b563663d9ebac6388265f23a66a298ccd3f05658"", ""source_version"": ""Original full 2016 primary JATS; wild-type versus engineered variant scope retained"", ""title"": ""Determinants of Cofactor Specificity for the Glucose-6-Phosphate Dehydrogenase from  Escherichia coli : Simulation, Kinetics and Evolutionary Studies"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4807051/fullTextXML""}, {""id"": ""UniProtKB:P0AC53"", ""source_sha256"": ""51d2a9f8fff9414d093e4e599441732315ef8834f9177cf7f33b056bae26515c"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; annotation evidence tiers retained"", ""title"": ""Glucose-6-phosphate 1-dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AC53.json""}]"	""
pathwaymech:KEGG_M00008_ed-edge-027_cd413d4bfd07	UniProtKB:P0AC53	pathwaymech:enables	KEGG:R10907	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1371/journal.pone.0152403.s002|KEGG:R10907|PMID:22519976|PMID:27010804|UniProtKB:P0AC53	Qualified current Zwf gene-product/activity attribution; both cofactor capacities are supported for modified E. coli preparations. Source beta specificity is curated, not experimentally exclusive. No isolated monomer sufficiency, exact historical construct equality or measured NAD-dependent in vivo ED flux is asserted.	"[{""reference_id"": ""UniProtKB:P0AC53"", ""source_assertion"": ""The K-12 zwf/b1852 entry has 491 residues and a generic glucose-6-phosphate/NADP catalytic annotation (ECO:0000255/HAMAP). This is not independent proof of exclusive beta use or of the NAD alternative."", ""source_locator"": ""/primaryAccession; /genes; /organism; /sequence; /comments/2""}, {""reference_id"": ""PMID:22519976"", ""source_assertion"": ""The purified modified E. coli preparation oxidized glucose 6-phosphate with NADP and with NAD, with markedly different affinities. The thrombin-cleaved construct retains twelve extra N-terminal residues. No exclusive-anomer assay or in vivo ED donor partition is established."", ""source_locator"": ""Results: NADP and NAD as co-substrates, Table 1; Experimental procedures: Purification; Discussion, paragraph on twelve extra N-terminal residues""}, {""reference_id"": ""PMID:27010804"", ""source_assertion"": ""The 2016 study retains a wild-type dual-cofactor comparator and engineered mutants. Its TEV construct is expected to retain Gly-His. These are preparation-specific observations, not exact equality to the current native sequence."", ""source_locator"": ""//sec[@id=\""sec005\""]/p | //table-wrap[@id=\""pone.0152403.t001\""]""}, {""reference_id"": ""DOI:10.1371/journal.pone.0152403.s002"", ""source_assertion"": ""S1 Table identifies Escherichia coli P0AC53 among sequences analyzed. This is an accession bridge for sequence analysis, not a complete kinetic construct sequence proof."", ""source_locator"": ""xl/worksheets/sheet1.xml row 9, decoded with xl/sharedStrings.xml""}, {""reference_id"": ""KEGG:R10907"", ""source_assertion"": ""KEGG supplies the beta-specific reaction convention. Applying the enzyme activity to this exact anomer-specific source equation is a qualified annotation-level inference, not direct exclusive-anomer characterization."", ""source_locator"": ""DEFINITION; EQUATION""}]"	"[{""id"": ""DOI:10.1371/journal.pone.0152403.s002"", ""source_sha256"": ""238d3554e2968b2251a43c3bfd5700691ae6928c2f835a112d163d49437ab1e5"", ""source_version"": ""Original supplementary workbook; accession row establishes sequence-analysis scope only"", ""title"": ""S1 Table. Accession numbers of bacterial G6PDHs"", ""url"": ""https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152403.s002&type=supplementary""}, {""id"": ""KEGG:R10907"", ""source_sha256"": ""347fb45378bd1495dcaa923861090c3f6fd4900d9bbd5fcf8f2312af881b6c00"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""beta-D-glucose-6-phosphate:NAD+ 1-oxidoreductase"", ""url"": ""https://rest.kegg.jp/get/R10907""}, {""id"": ""PMID:22519976"", ""source_version"": ""Full official main article inspected through web on 2026-10-11; local HTTP403 body is not full text; no local article digest claimed"", ""title"": ""The cofactor preference of glucose-6-phosphate dehydrogenase from Escherichia coli– modeling the physiological production of reduced cofactors"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2012.08610.x""}, {""id"": ""PMID:27010804"", ""source_sha256"": ""9435e6924beaed5f2a67c890b563663d9ebac6388265f23a66a298ccd3f05658"", ""source_version"": ""Original full 2016 primary JATS; wild-type versus engineered variant scope retained"", ""title"": ""Determinants of Cofactor Specificity for the Glucose-6-Phosphate Dehydrogenase from  Escherichia coli : Simulation, Kinetics and Evolutionary Studies"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4807051/fullTextXML""}, {""id"": ""UniProtKB:P0AC53"", ""source_sha256"": ""51d2a9f8fff9414d093e4e599441732315ef8834f9177cf7f33b056bae26515c"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; annotation evidence tiers retained"", ""title"": ""Glucose-6-phosphate 1-dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AC53.json""}]"	""
pathwaymech:KEGG_M00008_ed-edge-028_fc31dad97532	UniProtKB:P52697	pathwaymech:enables	RHEA:12557	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:15576773|UniProtKB:P52697	K-12 Pgl activity supported by deletion/complementation and cell-extract assays; no purified-enzyme assembly or bound metal requirement is inferred.	"[{""reference_id"": ""UniProtKB:P52697"", ""source_assertion"": ""The K-12 pgl/ybhE product is annotated with Rhea12556 hydrolysis using ECO:0000269/PMID15576773; the current native sequence is 331 residues."", ""source_locator"": ""/primaryAccession; /genes; /organism; /sequence; /comments/0; /comments/1""}, {""reference_id"": ""PMID:15576773"", ""source_assertion"": ""Mutations made in DY378 were moved to MG1655. Loss of pgl removed extract lactonase activity, and plasmid complementation restored it; the assay was explicitly not fully quantitative."", ""source_locator"": ""//section[@id=\""sec4\""]/p[1] | //section[@id=\""sec15\""]/p[1]""}]"	"[{""id"": ""PMID:15576773"", ""source_sha256"": ""5ab279ed68ec09f37a713dc74f4f29f2606ca55da8c424542a70f5d1922aaeab"", ""source_version"": ""Original full primary article HTML from PMC; retrieved 2026-10-11"", ""title"": ""Identification of the Escherichia coli K-12 ybhE Gene as pgl, Encoding 6-Phosphogluconolactonase"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC532434/""}, {""id"": ""UniProtKB:P52697"", ""source_sha256"": ""62a72b476202ae4cbb6705068ce59f2d320834c106f7edb82eb9a6f97736b467"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; annotation evidence tiers retained"", ""title"": ""6-phosphogluconolactonase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P52697.json""}]"	""
pathwaymech:KEGG_M00008_ed-edge-029_e05eb609d44c	UniProtKB:P0ADF6	pathwaymech:enables	RHEA:17278	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:17962400|UniProtKB:P0ADF6	Current Edd gene-product/activity relation with historical 603/602-residue conflict retained. Coupled lysate activity does not identify a purified assembly or make assay Mn/Mg obligatory cofactors.	"[{""reference_id"": ""UniProtKB:P0ADF6"", ""source_assertion"": ""The K-12 edd/b1851 entry annotates Rhea17277 activity with HAMAP and experimental citations. Its current 603-residue sequence has PLR at 252–254, versus historical AC; exact old construct equality is not established."", ""source_locator"": ""/primaryAccession; /genes; /organism; /sequence; /comments/1; /features/3""}, {""reference_id"": ""PMID:17962400"", ""source_assertion"": ""The edd ORF was amplified from K-12 DNA and expressed in BL21(DE3); active lysates were used. Mn supplementation during expression is not proof of an obligatory bound Mn cofactor."", ""source_locator"": ""//section[@id=\""sec10\""]/p[position()>=1 and position()<=3]""}]"	"[{""id"": ""PMID:17962400"", ""source_sha256"": ""7deed7c767741d64c1e2826d569b3ad570a6f0f950758838678fca9268966c7f"", ""source_version"": ""Original full primary article HTML from PMC; retrieved 2026-10-11"", ""title"": ""Mutagenesis of the phosphate-binding pocket of KDPG aldolase enhances selectivity for hydrophobic substrates"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2211689/""}, {""id"": ""UniProtKB:P0ADF6"", ""source_sha256"": ""f10c76ad12a1fab19ca5223419921de81eb5e02766240303d60871e084889445"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; annotation evidence tiers retained"", ""title"": ""Phosphogluconate dehydratase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ADF6.json""}]"	""
pathwaymech:KEGG_M00008_ed-edge-030_db681802da26	MetaCyc:KDPGALDOL-4OH2OXOGLUTARALDOL-CPLX	pathwaymech:catalyzes	RHEA:17090	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:KDPGALDOL-4OH2OXOGLUTARALDOL-CPLX|PMID:17962400|UniProtKB:P0A955	Source-verified Eda homotrimer cleaves KDPG. Other Eda substrate activities, coupled LDH/NADH reporting, and engineered-substrate specificity are outside this equation.	"[{""reference_id"": ""MetaCyc:KDPGALDOL-4OH2OXOGLUTARALDOL-CPLX"", ""source_assertion"": ""The native KHG/KDPG aldolase complex catalyzes KDPGALDOL-RXN via KDPGALDOL-ENZRXN. The same source also describes additional reactions outside this exact module."", ""source_locator"": ""/ptools-xml/Protein/catalyzes/Enzymatic-Reaction[@frameid=\""KDPGALDOL-ENZRXN\""]/reaction""}, {""reference_id"": ""UniProtKB:P0A955"", ""source_assertion"": ""The current Eda entry annotates KDPG cleavage to D-glyceraldehyde 3-phosphate and pyruvate with experimental evidence and identifies a homotrimer."", ""source_locator"": ""/comments/1; /comments/8""}, {""reference_id"": ""PMID:17962400"", ""source_assertion"": ""KDPG cleavage was assayed through pyruvate production using coupled lactate dehydrogenase. NADH consumption belongs to that reporter and is not part of the aldolase equation."", ""source_locator"": ""//section[@id=\""sec11\""]/p[1]""}]"	"[{""id"": ""MetaCyc:KDPGALDOL-4OH2OXOGLUTARALDOL-CPLX"", ""source_sha256"": ""451e7b9849601b5ff929bc6f17df97896efe412227145057a3f6510c7a347d84"", ""source_version"": ""MetaCyc 27.0 XML original; source-specific curated assembly and component identity"", ""title"": ""MetaCyc native KDPGALDOL-4OH2OXOGLUTARALDOL-CPLX"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:KDPGALDOL-4OH2OXOGLUTARALDOL-CPLX""}, {""id"": ""PMID:17962400"", ""source_sha256"": ""7deed7c767741d64c1e2826d569b3ad570a6f0f950758838678fca9268966c7f"", ""source_version"": ""Original full primary article HTML from PMC; retrieved 2026-10-11"", ""title"": ""Mutagenesis of the phosphate-binding pocket of KDPG aldolase enhances selectivity for hydrophobic substrates"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2211689/""}, {""id"": ""UniProtKB:P0A955"", ""source_sha256"": ""cc0f45dac0b56856dd1ebacc77c3de6be1fd6eb55d0c706ef072a3dbfaafc62c"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; annotation evidence tiers retained"", ""title"": ""KHG/KDPG aldolase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A955.json""}]"	""
pathwaymech:KEGG_M00008_ed-edge-031_940be51779a4	MetaCyc:KDPGALDOL-4OH2OXOGLUTARALDOL-CPLX	BFO:0000051	UniProtKB:P0A955	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:KDPGALDOL-4OH2OXOGLUTARALDOL-CPLX|MetaCyc:KDPGALDOL-4OH2OXOGLUTARALDOL-MONOMER|PMID:11274385|UniProtKB:P0A955	Stoichiometry: 3 identical Eda subunits. Native component identity and current protein annotation connect the complex; primary recombinant assembly supports trimerization without an exact donor-strain/construct equality claim.	"[{""reference_id"": ""MetaCyc:KDPGALDOL-4OH2OXOGLUTARALDOL-CPLX"", ""source_assertion"": ""The native complex contains three copies of KDPGALDOL-4OH2OXOGLUTARALDOL-MONOMER."", ""source_locator"": ""/ptools-xml/Protein/component""}, {""reference_id"": ""MetaCyc:KDPGALDOL-4OH2OXOGLUTARALDOL-MONOMER"", ""source_assertion"": ""The component object explicitly unifies UniProt P0A955; the curated native species is K-12 MG1655."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\""]; /ptools-xml/Protein/species""}, {""reference_id"": ""UniProtKB:P0A955"", ""source_assertion"": ""The current K-12 entry states Homotrimer with experimental evidence including PMID11274385."", ""source_locator"": ""/primaryAccession; /organism; /comments/8""}, {""reference_id"": ""PMID:11274385"", ""source_assertion"": ""The recombinant E. coli enzyme has trimeric subunit assembly. The eda/pKK-223 preparation is described; expression-host and SeMet preparation details do not independently establish a MG1655 donor strain."", ""source_locator"": ""//section[@id=\""sec2\""]/p[1] | //section[@id=\""sec5\""]/p[1]""}]"	"[{""id"": ""MetaCyc:KDPGALDOL-4OH2OXOGLUTARALDOL-CPLX"", ""source_sha256"": ""451e7b9849601b5ff929bc6f17df97896efe412227145057a3f6510c7a347d84"", ""source_version"": ""MetaCyc 27.0 XML original; source-specific curated assembly and component identity"", ""title"": ""MetaCyc native KDPGALDOL-4OH2OXOGLUTARALDOL-CPLX"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:KDPGALDOL-4OH2OXOGLUTARALDOL-CPLX""}, {""id"": ""MetaCyc:KDPGALDOL-4OH2OXOGLUTARALDOL-MONOMER"", ""source_sha256"": ""38548a6f3524d4e3d2f7cc21d1b487bcf49e099b8d5680ea998a89be6ec64036"", ""source_version"": ""MetaCyc 27.0 XML original; source-specific curated assembly and component identity"", ""title"": ""MetaCyc native KDPGALDOL-4OH2OXOGLUTARALDOL-MONOMER"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:KDPGALDOL-4OH2OXOGLUTARALDOL-MONOMER""}, {""id"": ""PMID:11274385"", ""source_sha256"": ""41f5604bedb4857764f066bee775ef55f99e434a601b9d40596d9344139fa719"", ""source_version"": ""Original full primary article HTML from PMC; retrieved 2026-10-11"", ""title"": ""Covalent intermediate trapped in 2-keto-3-deoxy-6- phosphogluconate (KDPG) aldolase structure at 1.95-Å resolution"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC31111/""}, {""id"": ""UniProtKB:P0A955"", ""source_sha256"": ""cc0f45dac0b56856dd1ebacc77c3de6be1fd6eb55d0c706ef072a3dbfaafc62c"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; annotation evidence tiers retained"", ""title"": ""KHG/KDPG aldolase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A955.json""}]"	""
pathwaymech:KEGG_M00008_ed-edge-032_edc2e941bf98	UniProtKB:P0ADF6	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:17102132|UniProtKB:P0ADF6	Qualified [4Fe-4S] annotation. Activity sensitivity/reactivation supports an iron-sulfur interpretation; exact cluster type and one-per-protein count retain their annotation inference tier.	"[{""reference_id"": ""UniProtKB:P0ADF6"", ""source_assertion"": ""The entry assigns one [4Fe-4S] cluster using ECO:0000250, ECO:0000255 and curator inference ECO:0000305. The one-cluster note is similarity/HAMAP evidence, not direct Edd cluster stoichiometry measurement."", ""source_locator"": ""/comments/2/cofactors/0; /comments/2/note""}, {""reference_id"": ""PMID:17102132"", ""source_assertion"": ""Edd lysate activity was peroxide-sensitive and recoverable with iron/DTT. The explicit [3Fe-4S] EPR signal in this passage belongs to fumarase A; it is not an Edd spectrum."", ""source_locator"": ""//*[@id=\""P9\""] | //*[@id=\""P30\""]""}]"	"[{""id"": ""PMID:17102132"", ""source_sha256"": ""e57d324fa18469cc926407fa14c681488d9acf38f0c2ba86539162da1735c075"", ""source_version"": ""Original full primary article HTML from PMC; retrieved 2026-10-11"", ""title"": ""MICROMOLAR INTRACELLULAR HYDROGEN PEROXIDE DISRUPTS METABOLISM BY DAMAGING IRON-SULFUR ENZYMES"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC5136138/""}, {""id"": ""UniProtKB:P0ADF6"", ""source_sha256"": ""f10c76ad12a1fab19ca5223419921de81eb5e02766240303d60871e084889445"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; annotation evidence tiers retained"", ""title"": ""Phosphogluconate dehydratase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ADF6.json""}]"	""
pathwaymech:KEGG_M00008_ed-edge-033_342f133fa9b0	UniProtKB:P0A955	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A955	Annotated Eda location; this does not infer a directly measured compartment for every module component.	"[{""reference_id"": ""UniProtKB:P0A955"", ""source_assertion"": ""The entry assigns cytoplasm as cellular location with ECO:0000305 curator inference."", ""source_locator"": ""/comments/10/subcellularLocations/0/location""}]"	"[{""id"": ""UniProtKB:P0A955"", ""source_sha256"": ""cc0f45dac0b56856dd1ebacc77c3de6be1fd6eb55d0c706ef072a3dbfaafc62c"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; annotation evidence tiers retained"", ""title"": ""KHG/KDPG aldolase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A955.json""}]"	""
pathwaymech:KEGG_M00008_ed-edge-034_7a3c77c7287c	KEGG:R02736	RO:0002413	RHEA:12557	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:57955|KEGG:C01236|KEGG:M00008|KEGG:R02736|RHEA:12557	The shared CHEBI:57955 product/substrate links these positions. The two first-position alternatives independently feed hydrolysis; neither precedes or feeds the other.	"[{""reference_id"": ""KEGG:M00008"", ""source_assertion"": ""The native definition orders oxidation, lactone hydrolysis, dehydration and aldol cleavage, with both oxidation alternatives in the same first position."", ""source_locator"": ""DEFINITION; ORTHOLOGY""}, {""reference_id"": ""KEGG:R02736"", ""source_assertion"": ""The original beta-specific equation is C01172 + C00006 <=> C01236 + C00005 + C00080. Forward module use is selected; the native equation is reversible."", ""source_locator"": ""EQUATION; DEFINITION""}, {""reference_id"": ""KEGG:C01236"", ""source_assertion"": ""The original compound entry and its ATOM/BOND fields fix the native chemical identity. The selected charged ChEBI form preserves connectivity and stereochemistry with explicit acid-base normalization; no neutral/charged exactMatch is asserted."", ""source_locator"": ""ENTRY; NAME; FORMULA; ATOM; BOND""}, {""reference_id"": ""CHEBI:57955"", ""source_assertion"": ""The issuing structure, formula and charge specify the selected normalized reaction participant. Its protonation is compared with the original KEGG structure; coefficients balance this complete charged equation."", ""source_locator"": ""statements subject=CHEBI:57955; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}, {""reference_id"": ""RHEA:12557"", ""source_assertion"": ""The original directional substrates chain contains CHEBI:57955 with coefficient 1. The formula and charge belong to the linked native compound, not an inferred label mapping."", ""source_locator"": ""RHEA:12557 rh:substrates -> http://rdf.rhea-db.org/12556_L rh:contains1 -> http://rdf.rhea-db.org/Participant_12556_compound_3399 rh:compound -> http://rdf.rhea-db.org/Compound_3399 rh:accession/formula/charge""}]"	"[{""id"": ""CHEBI:57955"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; digest covers entire original uncompressed Semantic SQL database"", ""title"": ""6-O-phosphonato-D-glucono-1,5-lactone(2-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""KEGG:C01236"", ""source_sha256"": ""bbe6627658daa95e84ea241d9d38cafd5dee360294cba091bf709b323f2b574e"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""D-Glucono-1,5-lactone 6-phosphate;\n6-Phospho-D-glucono-1,5-lactone"", ""url"": ""https://rest.kegg.jp/get/C01236""}, {""id"": ""KEGG:M00008"", ""source_sha256"": ""5f1362bca2e9cc0e5442e99f033836580a5ba23ba2bb80c1f3ce12721420de3a"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate"", ""url"": ""https://rest.kegg.jp/get/M00008""}, {""id"": ""KEGG:R02736"", ""source_sha256"": ""885ed16e1be80bec5dff01f3fa12222ca605e7f86e31b37e7bd201119c021ee7"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""beta-D-glucose-6-phosphate:NADP+ 1-oxoreductase"", ""url"": ""https://rest.kegg.jp/get/R02736""}, {""id"": ""RHEA:12557"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""6-phospho-D-glucono-1,5-lactone + H2O => 6-phospho-D-gluconate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:KEGG_M00008_ed-edge-035_f8a3a10e2db4	KEGG:R10907	RO:0002413	RHEA:12557	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:57955|KEGG:C01236|KEGG:M00008|KEGG:R10907|RHEA:12557	The shared CHEBI:57955 product/substrate links these positions. The two first-position alternatives independently feed hydrolysis; neither precedes or feeds the other.	"[{""reference_id"": ""KEGG:M00008"", ""source_assertion"": ""The native definition orders oxidation, lactone hydrolysis, dehydration and aldol cleavage, with both oxidation alternatives in the same first position."", ""source_locator"": ""DEFINITION; ORTHOLOGY""}, {""reference_id"": ""KEGG:R10907"", ""source_assertion"": ""The original beta-specific equation is C01172 + C00003 <=> C01236 + C00004 + C00080. Forward module use is selected; the native equation is reversible."", ""source_locator"": ""EQUATION; DEFINITION""}, {""reference_id"": ""KEGG:C01236"", ""source_assertion"": ""The original compound entry and its ATOM/BOND fields fix the native chemical identity. The selected charged ChEBI form preserves connectivity and stereochemistry with explicit acid-base normalization; no neutral/charged exactMatch is asserted."", ""source_locator"": ""ENTRY; NAME; FORMULA; ATOM; BOND""}, {""reference_id"": ""CHEBI:57955"", ""source_assertion"": ""The issuing structure, formula and charge specify the selected normalized reaction participant. Its protonation is compared with the original KEGG structure; coefficients balance this complete charged equation."", ""source_locator"": ""statements subject=CHEBI:57955; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}, {""reference_id"": ""RHEA:12557"", ""source_assertion"": ""The original directional substrates chain contains CHEBI:57955 with coefficient 1. The formula and charge belong to the linked native compound, not an inferred label mapping."", ""source_locator"": ""RHEA:12557 rh:substrates -> http://rdf.rhea-db.org/12556_L rh:contains1 -> http://rdf.rhea-db.org/Participant_12556_compound_3399 rh:compound -> http://rdf.rhea-db.org/Compound_3399 rh:accession/formula/charge""}]"	"[{""id"": ""CHEBI:57955"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; digest covers entire original uncompressed Semantic SQL database"", ""title"": ""6-O-phosphonato-D-glucono-1,5-lactone(2-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""KEGG:C01236"", ""source_sha256"": ""bbe6627658daa95e84ea241d9d38cafd5dee360294cba091bf709b323f2b574e"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""D-Glucono-1,5-lactone 6-phosphate;\n6-Phospho-D-glucono-1,5-lactone"", ""url"": ""https://rest.kegg.jp/get/C01236""}, {""id"": ""KEGG:M00008"", ""source_sha256"": ""5f1362bca2e9cc0e5442e99f033836580a5ba23ba2bb80c1f3ce12721420de3a"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate"", ""url"": ""https://rest.kegg.jp/get/M00008""}, {""id"": ""KEGG:R10907"", ""source_sha256"": ""347fb45378bd1495dcaa923861090c3f6fd4900d9bbd5fcf8f2312af881b6c00"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""beta-D-glucose-6-phosphate:NAD+ 1-oxidoreductase"", ""url"": ""https://rest.kegg.jp/get/R10907""}, {""id"": ""RHEA:12557"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""6-phospho-D-glucono-1,5-lactone + H2O => 6-phospho-D-gluconate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:KEGG_M00008_ed-edge-036_faafa1913eec	RHEA:12557	RO:0002413	RHEA:17278	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00008|RHEA:12557|RHEA:17278	The shared CHEBI:58759 product/substrate links these positions. The two first-position alternatives independently feed hydrolysis; neither precedes or feeds the other.	"[{""reference_id"": ""KEGG:M00008"", ""source_assertion"": ""The native definition orders oxidation, lactone hydrolysis, dehydration and aldol cleavage, with both oxidation alternatives in the same first position."", ""source_locator"": ""DEFINITION; ORTHOLOGY""}, {""reference_id"": ""RHEA:12557"", ""source_assertion"": ""The original directional products chain contains CHEBI:58759 with coefficient 1. The formula and charge belong to the linked native compound, not an inferred label mapping."", ""source_locator"": ""RHEA:12557 rh:products -> http://rdf.rhea-db.org/12556_R rh:contains1 -> http://rdf.rhea-db.org/Participant_12556_compound_4577 rh:compound -> http://rdf.rhea-db.org/Compound_4577 rh:accession/formula/charge""}, {""reference_id"": ""RHEA:17278"", ""source_assertion"": ""The original directional substrates chain contains CHEBI:58759 with coefficient 1. The formula and charge belong to the linked native compound, not an inferred label mapping."", ""source_locator"": ""RHEA:17278 rh:substrates -> http://rdf.rhea-db.org/17277_L rh:contains1 -> http://rdf.rhea-db.org/Participant_17277_compound_4577 rh:compound -> http://rdf.rhea-db.org/Compound_4577 rh:accession/formula/charge""}]"	"[{""id"": ""KEGG:M00008"", ""source_sha256"": ""5f1362bca2e9cc0e5442e99f033836580a5ba23ba2bb80c1f3ce12721420de3a"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate"", ""url"": ""https://rest.kegg.jp/get/M00008""}, {""id"": ""RHEA:12557"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""6-phospho-D-glucono-1,5-lactone + H2O => 6-phospho-D-gluconate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:17278"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""6-phospho-D-gluconate => 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:KEGG_M00008_ed-edge-037_8a0ba6d20da0	RHEA:17278	RO:0002413	RHEA:17090	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00008|RHEA:17090|RHEA:17278	The shared CHEBI:57569 product/substrate links these positions. The two first-position alternatives independently feed hydrolysis; neither precedes or feeds the other.	"[{""reference_id"": ""KEGG:M00008"", ""source_assertion"": ""The native definition orders oxidation, lactone hydrolysis, dehydration and aldol cleavage, with both oxidation alternatives in the same first position."", ""source_locator"": ""DEFINITION; ORTHOLOGY""}, {""reference_id"": ""RHEA:17278"", ""source_assertion"": ""The original directional products chain contains CHEBI:57569 with coefficient 1. The formula and charge belong to the linked native compound, not an inferred label mapping."", ""source_locator"": ""RHEA:17278 rh:products -> http://rdf.rhea-db.org/17277_R rh:contains1 -> http://rdf.rhea-db.org/Participant_17277_compound_5038 rh:compound -> http://rdf.rhea-db.org/Compound_5038 rh:accession/formula/charge""}, {""reference_id"": ""RHEA:17090"", ""source_assertion"": ""The original directional substrates chain contains CHEBI:57569 with coefficient 1. The formula and charge belong to the linked native compound, not an inferred label mapping."", ""source_locator"": ""RHEA:17090 rh:substrates -> http://rdf.rhea-db.org/17089_L rh:contains1 -> http://rdf.rhea-db.org/Participant_17089_compound_5038 rh:compound -> http://rdf.rhea-db.org/Compound_5038 rh:accession/formula/charge""}]"	"[{""id"": ""KEGG:M00008"", ""source_sha256"": ""5f1362bca2e9cc0e5442e99f033836580a5ba23ba2bb80c1f3ce12721420de3a"", ""source_version"": ""Original KEGG REST flat file retrieved 2026-10-11; native ENTRY and complete fields retained"", ""title"": ""Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate"", ""url"": ""https://rest.kegg.jp/get/M00008""}, {""id"": ""RHEA:17090"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""2-dehydro-3-deoxy-6-phospho-D-gluconate => D-glyceraldehyde 3-phosphate + pyruvate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:17278"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original compressed RDF; selected directional reaction and coefficient predicates"", ""title"": ""6-phospho-D-gluconate => 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-001_fd151a61c33e	gomodel:RXN-12263	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN-12263 RO:0002234 gomodel:CHEBI_29888_RXN-12263."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/0; endpoint types: /individuals/11/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-002_f1a7d59b7175	gomodel:RXN66-281	RO:0002234	CHEBI:15440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-281 RO:0002234 gomodel:CHEBI_15440_RXN66-281."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/1; endpoint types: /individuals/13/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-003_cab115fde889	gomodel:RXN66-281	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-281 RO:0002234 gomodel:CHEBI_29888_RXN66-281."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/2; endpoint types: /individuals/13/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-004_79bf6f1adbe4	gomodel:RXN66-281	RO:0002234	CHEBI:13390	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-281 RO:0002234 gomodel:CHEBI_13390_RXN66-281."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/3; endpoint types: /individuals/13/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-005_f8b2c0a8719a	gomodel:RXN66-281	RO:0002233	CHEBI:13392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-281 RO:0002233 gomodel:CHEBI_13392_RXN66-281."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/4; endpoint types: /individuals/13/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-006_204f80235048	SGD:S000001233	pathwaymech:enables	gomodel:RXN-12263	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN-12263 RO:0002333 gomodel:YHR190W-MONOMER_RXN-12263_controller."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/5; endpoint types: /individuals/11/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-008_85dd917b91f3	gomodel:RXN3O-9816	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9816 RO:0002234 gomodel:CHEBI_15377_RXN3O-9816."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/7; endpoint types: /individuals/12/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-009_1e4b334a3528	gomodel:RXN3O-9816	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9816 RO:0002233 gomodel:CHEBI_15379_RXN3O-9816."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/8; endpoint types: /individuals/12/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-010_68234b970564	gomodel:RXN3O-9816	RO:0002234	gomodel:YeastPathways_PWY-5670-1/654d809000002591	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9816 RO:0002234 gomodel:YeastPathways_PWY-5670-1/654d809000002591."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/9; endpoint types: /individuals/12/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-011_389b1fbf1932	SGD:S000003407	pathwaymech:enables	gomodel:RXN3O-9816	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9816 RO:0002333 gomodel:YGR175C-MONOMER_RXN3O-9816_controller."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/10; endpoint types: /individuals/12/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-012_d84f660a0603	gomodel:RXN3O-9816	RO:0002233	CHEBI:15440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9816 RO:0002233 gomodel:CHEBI_15440_RXN66-281."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/11; endpoint types: /individuals/12/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-013_8bcc6706b795	gomodel:RXN3O-9816	RO:0002234	CHEBI:15441	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9816 RO:0002234 gomodel:CHEBI_15441_RXN3O-9816."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/12; endpoint types: /individuals/12/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-014_2ce20e735e46	SGD:S000001233	pathwaymech:enables	gomodel:RXN66-281	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-281 RO:0002333 gomodel:YHR190W-MONOMER_RXN66-281_controller."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/13; endpoint types: /individuals/13/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-015_8adce0bdbf19	gomodel:RXN-12263	RO:0002234	CHEBI:57310	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN-12263 RO:0002234 gomodel:CHEBI_57310_RXN-12263."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/14; endpoint types: /individuals/11/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-016_eda6db217049	gomodel:RXN3O-9816	BFO:0000050	GO:0016104	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9816 BFO:0000050 gomodel:YeastPathways_PWY-5670-1/YeastPathways_PWY-5670-1."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/15; endpoint types: /individuals/12/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-017_50de45649afa	gomodel:RXN-12263	BFO:0000050	GO:0016104	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN-12263 BFO:0000050 gomodel:YeastPathways_PWY-5670-1/YeastPathways_PWY-5670-1."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/16; endpoint types: /individuals/11/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-018_f1c863874a22	gomodel:RXN-12263	RO:0002233	CHEBI:175763	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN-12263 RO:0002233 gomodel:CHEBI_175763_RXN-12263."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/17; endpoint types: /individuals/11/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-019_1fd2d4f24b80	gomodel:RXN66-281	RO:0002233	CHEBI:57310	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-281 RO:0002233 gomodel:CHEBI_57310_RXN-12263."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/18; endpoint types: /individuals/13/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-020_ca626f8c8833	gomodel:RXN66-281	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-281 RO:0002233 gomodel:CHEBI_15378_RXN66-281."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/19; endpoint types: /individuals/13/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-021_ffe4b2e166b5	gomodel:RXN66-281	BFO:0000050	GO:0016104	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-281 BFO:0000050 gomodel:YeastPathways_PWY-5670-1/YeastPathways_PWY-5670-1."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/20; endpoint types: /individuals/13/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_edge-022_26516e9774ae	gomodel:RXN3O-9816	RO:0002233	gomodel:YeastPathways_PWY-5670-1/654d809000002611	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5670-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9816 RO:0002233 gomodel:YeastPathways_PWY-5670-1/654d809000002611."", ""source_locator"": ""./YeastPathways_PWY-5670-1.json#/facts/21; endpoint types: /individuals/12/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5670-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-5670-1.json"", ""title"": ""GO-CAM epoxysqualene biosynthesis model YeastPathways_PWY-5670-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_location-676821ad92fb_2689a4e1195a	SGD:S000001233	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P29704	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:1807826) Topology: Single-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P29704"", ""source_assertion"": ""UniProtKB:P29704 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/821/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P29704"", ""source_assertion"": ""UniProtKB:P29704 has the exact SGD cross-reference SGD:S000001233."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/821/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P29704"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P29704 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_location-73e9b469e315_6f83d9c6711e	SGD:S000003407	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32476	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:9450962) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P32476"", ""source_assertion"": ""UniProtKB:P32476 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/917/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32476"", ""source_assertion"": ""UniProtKB:P32476 has the exact SGD cross-reference SGD:S000003407."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/917/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32476"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32476 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_location-8bd2396f577c_4b2081681d8e	SGD:S000003407	RO:0001025	GO:0005811	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32476	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:9450962)	"[{""reference_id"": ""UniProtKB:P32476"", ""source_assertion"": ""UniProtKB:P32476 annotates location Lipid droplet (SL-0154)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/917/comments/1/subcellularLocations/2; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32476"", ""source_assertion"": ""UniProtKB:P32476 has the exact SGD cross-reference SGD:S000003407."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/917/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32476"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32476 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_cofactor-d4c61b555765_5f6b7d875a99	SGD:S000001233	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P29704	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:8323279)	"[{""reference_id"": ""UniProtKB:P29704"", ""source_assertion"": ""UniProtKB:P29704 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/821/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P29704"", ""source_assertion"": ""UniProtKB:P29704 has the exact SGD cross-reference SGD:S000001233."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/821/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P29704"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P29704 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5670-1_cofactor-429df05173b0_1035e1716c42	SGD:S000003407	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32476	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q14534)	"[{""reference_id"": ""UniProtKB:P32476"", ""source_assertion"": ""UniProtKB:P32476 annotates CHEBI:57692 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/917/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P32476"", ""source_assertion"": ""UniProtKB:P32476 has the exact SGD cross-reference SGD:S000003407."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/917/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32476"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32476 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-001_dc9328e478f2	gomodel:RXN3O-178	RO:0002413	gomodel:RXN3O-203	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-178 RO:0002413 gomodel:RXN3O-203."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/0; endpoint types: /individuals/24/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-002_f49bd879e25a	gomodel:1.3.1.71-RXN	RO:0002233	CHEBI:18249	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:1.3.1.71-RXN RO:0002233 gomodel:CHEBI_18249_RXN3O-9828."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/1; endpoint types: /individuals/72/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-003_f4c2b9fe27d8	gomodel:1.3.1.71-RXN	RO:0002234	CHEBI:16933	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:1.3.1.71-RXN RO:0002234 gomodel:CHEBI_16933_1.3.1.71-RXN."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/2; endpoint types: /individuals/72/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-004_cdaa0b6a10c2	gomodel:1.3.1.71-RXN	BFO:0000050	GO:0006696	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:1.3.1.71-RXN BFO:0000050 gomodel:YeastPathways_PWY-6075-1/YeastPathways_PWY-6075-1."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/3; endpoint types: /individuals/72/type; /individuals/73/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-005_bed5694fd5d2	gomodel:RXN3O-9827	RO:0002233	CHEBI:50586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9827 RO:0002233 gomodel:CHEBI_50586_RXN3O-203."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/4; endpoint types: /individuals/26/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-006_3d97be6bdc38	SGD:S000004046	pathwaymech:enables	gomodel:RXN3O-9827	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9827 RO:0002333 gomodel:YLR056W-MONOMER_RXN3O-9827_controller."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/5; endpoint types: /individuals/26/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-007_c6752e109037	gomodel:1.3.1.71-RXN	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:1.3.1.71-RXN RO:0002234 gomodel:CHEBI_58349_1.3.1.71-RXN."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/6; endpoint types: /individuals/72/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-009_26318a56b8f9	SGD:S000002980	pathwaymech:enables	gomodel:1.3.1.71-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:1.3.1.71-RXN RO:0002333 gomodel:YGL012W-MONOMER_1.3.1.71-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/8; endpoint types: /individuals/72/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-010_7a40796acc39	gomodel:RXN3O-9828	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9828 RO:0002234 gomodel:CHEBI_58349_RXN3O-9828."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/9; endpoint types: /individuals/27/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-011_79cab2882213	gomodel:RXN3O-9828	BFO:0000050	GO:0006696	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9828 BFO:0000050 gomodel:YeastPathways_PWY-6075-1/YeastPathways_PWY-6075-1."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/10; endpoint types: /individuals/27/type; /individuals/73/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-012_f17d6dd0a316	gomodel:RXN3O-9827	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9827 RO:0002234 gomodel:CHEBI_15377_RXN3O-9827."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/11; endpoint types: /individuals/26/type; /individuals/0/type""}, {""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9827 RO:0002234 gomodel:YeastPathways_PWY-6075-1/654d809000002548."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/21; endpoint types: /individuals/26/type; /individuals/78/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-013_cbf7cbe3cf0e	SGD:S000004815	pathwaymech:enables	gomodel:RXN3O-203	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-203 RO:0002333 gomodel:YMR202W-MONOMER_RXN3O-203_controller."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/12; endpoint types: /individuals/25/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-014_2ead9a663c65	gomodel:RXN3O-9827	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9827 RO:0002233 gomodel:CHEBI_15379_RXN3O-9827."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/13; endpoint types: /individuals/26/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-015_70c6242384df	gomodel:RXN3O-9827	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9827 RO:0002233 gomodel:CHEBI_57783_RXN3O-9827."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/14; endpoint types: /individuals/26/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-016_c65c3d4ed0b3	gomodel:RXN3O-9828	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9828 RO:0002233 gomodel:CHEBI_57783_RXN3O-9828."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/15; endpoint types: /individuals/27/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-017_f7b4b6bdc9e6	gomodel:RXN3O-178	RO:0002233	CHEBI:18252	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-178 RO:0002233 gomodel:CHEBI_18252_RXN3O-178."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/16; endpoint types: /individuals/24/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-018_80666eddbb70	gomodel:RXN3O-9828	RO:0002234	CHEBI:18249	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9828 RO:0002234 gomodel:CHEBI_18249_RXN3O-9828."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/17; endpoint types: /individuals/27/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-019_6acf75548890	gomodel:RXN3O-9828	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9828 RO:0002234 gomodel:YeastPathways_PWY-6075-1/654d809000002553."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/18; endpoint types: /individuals/27/type; /individuals/80/type""}, {""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9828 RO:0002234 gomodel:CHEBI_15377_RXN3O-9828."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/34; endpoint types: /individuals/27/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-020_7c8c188b5b66	gomodel:RXN3O-9828	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9828 RO:0002233 gomodel:CHEBI_15378_RXN3O-9828."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/19; endpoint types: /individuals/27/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-021_d4e9e281995e	gomodel:1.3.1.71-RXN	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:1.3.1.71-RXN RO:0002233 gomodel:CHEBI_57783_1.3.1.71-RXN."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/20; endpoint types: /individuals/72/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-022_8ce7e6841eab	gomodel:RXN3O-9828	RO:0002413	gomodel:1.3.1.71-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9828 RO:0002413 gomodel:1.3.1.71-RXN."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/22; endpoint types: /individuals/27/type; /individuals/72/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-024_e1a434c5ac3a	gomodel:RXN3O-203	BFO:0000050	GO:0006696	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-203 BFO:0000050 gomodel:YeastPathways_PWY-6075-1/YeastPathways_PWY-6075-1."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/24; endpoint types: /individuals/25/type; /individuals/73/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-026_4f9a5a116372	gomodel:RXN3O-178	RO:0002234	CHEBI:17038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-178 RO:0002234 gomodel:CHEBI_17038_RXN3O-178."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/26; endpoint types: /individuals/24/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-027_a410b217b7e0	gomodel:RXN3O-9827	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9827 RO:0002233 gomodel:CHEBI_15378_RXN3O-9827."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/27; endpoint types: /individuals/26/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-028_80b1284f2f0b	gomodel:RXN3O-9827	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9827 RO:0002234 gomodel:CHEBI_58349_RXN3O-9827."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/28; endpoint types: /individuals/26/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-029_32be00e4e776	gomodel:RXN3O-9827	BFO:0000050	GO:0006696	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9827 BFO:0000050 gomodel:YeastPathways_PWY-6075-1/YeastPathways_PWY-6075-1."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/29; endpoint types: /individuals/26/type; /individuals/73/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-030_603ce28c4208	gomodel:1.3.1.71-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:1.3.1.71-RXN RO:0002233 gomodel:CHEBI_15378_1.3.1.71-RXN."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/30; endpoint types: /individuals/72/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-032_5670e278292e	gomodel:RXN3O-9828	RO:0002233	CHEBI:52972	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9828 RO:0002233 gomodel:CHEBI_52972_RXN3O-9827."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/32; endpoint types: /individuals/27/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-033_7010a1c66004	gomodel:RXN3O-9828	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9828 RO:0002233 gomodel:CHEBI_15379_RXN3O-9828."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/33; endpoint types: /individuals/27/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-034_567a40bb5bd5	gomodel:RXN3O-203	RO:0002234	CHEBI:50586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-203 RO:0002234 gomodel:CHEBI_50586_RXN3O-203."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/35; endpoint types: /individuals/25/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-035_1e97e974f5ab	gomodel:RXN3O-178	BFO:0000050	GO:0006696	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-178 BFO:0000050 gomodel:YeastPathways_PWY-6075-1/YeastPathways_PWY-6075-1."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/36; endpoint types: /individuals/24/type; /individuals/73/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-036_6d7186b8c06d	SGD:S000004467	pathwaymech:enables	gomodel:RXN3O-178	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-178 RO:0002333 gomodel:MONOMER3O-188_RXN3O-178_controller."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/37; endpoint types: /individuals/24/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-037_82b84ccdae8c	gomodel:RXN3O-203	RO:0002233	CHEBI:17038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-203 RO:0002233 gomodel:CHEBI_17038_RXN3O-178."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/38; endpoint types: /individuals/25/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-039_75d35b402b9d	gomodel:RXN3O-9827	RO:0002413	gomodel:RXN3O-9828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9827 RO:0002413 gomodel:RXN3O-9828."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/40; endpoint types: /individuals/26/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-040_95b1f136b2a4	gomodel:RXN3O-203	RO:0002413	gomodel:RXN3O-9827	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-203 RO:0002413 gomodel:RXN3O-9827."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/41; endpoint types: /individuals/25/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-041_b698a1170908	gomodel:RXN3O-9827	RO:0002234	CHEBI:52972	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9827 RO:0002234 gomodel:CHEBI_52972_RXN3O-9827."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/42; endpoint types: /individuals/26/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-042_0fbbf0d93874	gomodel:RXN3O-178	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-178 RO:0002234 gomodel:CHEBI_15378_RXN3O-178."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/43; endpoint types: /individuals/24/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-043_7692078a9dcb	gomodel:RXN3O-178	RO:0002233	CHEBI:59789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-178 RO:0002233 gomodel:CHEBI_59789_RXN3O-178."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/44; endpoint types: /individuals/24/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-044_de4f5840266d	SGD:S000004617	pathwaymech:enables	gomodel:RXN3O-9828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9828 RO:0002333 gomodel:MONOMER3O-232_RXN3O-9828_controller."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/45; endpoint types: /individuals/27/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_edge-045_a0470fdde338	gomodel:RXN3O-178	RO:0002234	CHEBI:57856	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6075-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-178 RO:0002234 gomodel:CHEBI_57856_RXN3O-178."", ""source_locator"": ""./YeastPathways_PWY-6075-1.json#/facts/46; endpoint types: /individuals/24/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6075-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-6075-1.json"", ""title"": ""GO-CAM ergosterol biosynthesis I model YeastPathways_PWY-6075-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_location-bf8ac449fd99_a086d88fde0d	SGD:S000004046	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32353	Physical protein location from reviewed UniProt. ECO:0000305 Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P32353"", ""source_assertion"": ""UniProtKB:P32353 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/885/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32353"", ""source_assertion"": ""UniProtKB:P32353 has the exact SGD cross-reference SGD:S000004046."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/885/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32353"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32353 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_location-ef548de791a6_3bda8e682405	SGD:S000002980	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P25340	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10722850) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P25340"", ""source_assertion"": ""UniProtKB:P25340 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/671/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P25340"", ""source_assertion"": ""UniProtKB:P25340 has the exact SGD cross-reference SGD:S000002980."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/671/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P25340"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P25340 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_location-4cbfcf3c8151_534a307001d2	SGD:S000004815	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32352	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:15716577) Topology: Single-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P32352"", ""source_assertion"": ""UniProtKB:P32352 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/884/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32352"", ""source_assertion"": ""UniProtKB:P32352 has the exact SGD cross-reference SGD:S000004815."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/884/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32352"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32352 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_location-889f87298f00_883fe3d6b972	SGD:S000004467	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P25087	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:6363386)	"[{""reference_id"": ""UniProtKB:P25087"", ""source_assertion"": ""UniProtKB:P25087 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/658/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P25087"", ""source_assertion"": ""UniProtKB:P25087 has the exact SGD cross-reference SGD:S000004467."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/658/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P25087"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P25087 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_location-08ef9a74682d_e7f4d4f0354c	SGD:S000004617	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P54781	Physical protein location from reviewed UniProt. ECO:0000305 Topology: Single-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P54781"", ""source_assertion"": ""UniProtKB:P54781 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2328/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P54781"", ""source_assertion"": ""UniProtKB:P54781 has the exact SGD cross-reference SGD:S000004617."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2328/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P54781"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P54781 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_cofactor-a4874d9a4ef3_7896b97bc9f1	SGD:S000004046	pathwaymech:has_cofactor	CHEBI:24875	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32353	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P53045)	"[{""reference_id"": ""UniProtKB:P32353"", ""source_assertion"": ""UniProtKB:P32353 annotates CHEBI:24875 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/885/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P32353"", ""source_assertion"": ""UniProtKB:P32353 has the exact SGD cross-reference SGD:S000004046."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/885/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32353"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32353 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6075-1_cofactor-a50dafd38e6a_056d8f6bb3ad	SGD:S000004617	pathwaymech:has_cofactor	CHEBI:30413	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P54781	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P04798)	"[{""reference_id"": ""UniProtKB:P54781"", ""source_assertion"": ""UniProtKB:P54781 annotates CHEBI:30413 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2328/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P54781"", ""source_assertion"": ""UniProtKB:P54781 has the exact SGD cross-reference SGD:S000004617."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2328/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P54781"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P54781 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-001_e5db6cc57d54	CHEBI:35235	pathwaymech:consumes	RHEA:13286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13286		"[{""reference_id"": ""RHEA:13286"", ""source_assertion"": ""RHEA:13286 assigns CHEBI:35235 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13286']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13285_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13285_compound_2467']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_2467)""}]"	"[{""id"": ""RHEA:13286"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 13286 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-002_74dfdc18309a	CHEBI:29985	pathwaymech:consumes	RHEA:13286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13286		"[{""reference_id"": ""RHEA:13286"", ""source_assertion"": ""RHEA:13286 assigns CHEBI:29985 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13286']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13285_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13285_compound_2079']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_2079)""}]"	"[{""id"": ""RHEA:13286"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 13286 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-003_d7503eaf8c96	CHEBI:30616	pathwaymech:consumes	RHEA:13286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13286		"[{""reference_id"": ""RHEA:13286"", ""source_assertion"": ""RHEA:13286 assigns CHEBI:30616 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13286']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13285_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13285_compound_6372']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_6372)""}]"	"[{""id"": ""RHEA:13286"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 13286 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-004_07b66e2d8c07	RHEA:13286	pathwaymech:produces	CHEBI:58173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13286		"[{""reference_id"": ""RHEA:13286"", ""source_assertion"": ""RHEA:13286 assigns CHEBI:58173 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13286']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13285_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13285_compound_1121']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_1121)""}]"	"[{""id"": ""RHEA:13286"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 13286 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-005_e5fbf847a734	RHEA:13286	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13286		"[{""reference_id"": ""RHEA:13286"", ""source_assertion"": ""RHEA:13286 assigns CHEBI:456216 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13286']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13285_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13285_compound_2710']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_2710)""}]"	"[{""id"": ""RHEA:13286"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 13286 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-006_73a37351a0df	RHEA:13286	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13286		"[{""reference_id"": ""RHEA:13286"", ""source_assertion"": ""RHEA:13286 assigns CHEBI:43474 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13286']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13285_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13285_compound_5518']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5518)""}]"	"[{""id"": ""RHEA:13286"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 13286 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-007_f14f07d8ab51	RHEA:13286	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13286		"[{""reference_id"": ""RHEA:13286"", ""source_assertion"": ""RHEA:13286 assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13286']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13285_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13285_compound_3249']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3249)""}]"	"[{""id"": ""RHEA:13286"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 13286 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-008_818eff167c47	CHEBI:57595	pathwaymech:consumes	RHEA:38472	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38472		"[{""reference_id"": ""RHEA:38472"", ""source_assertion"": ""RHEA:38472 assigns CHEBI:57595 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/38472']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/38471_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_38471_compound_3613']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3613)""}]"	"[{""id"": ""RHEA:38472"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 38472 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-009_a5599a69c178	CHEBI:59789	pathwaymech:consumes	RHEA:38472	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38472	Stoichiometric coefficient 3.	"[{""reference_id"": ""RHEA:38472"", ""source_assertion"": ""RHEA:38472 assigns CHEBI:59789 to its substrates with coefficient 3."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/38472']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/38471_L']/rh:contains3[@rdf:resource='http://rdf.rhea-db.org/Participant_38471_compound_6127']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_6127)""}]"	"[{""id"": ""RHEA:38472"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 38472 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-010_0ad8941f687b	RHEA:38472	pathwaymech:produces	CHEBI:15781	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38472		"[{""reference_id"": ""RHEA:38472"", ""source_assertion"": ""RHEA:38472 assigns CHEBI:15781 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/38472']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/38471_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_38471_compound_4809']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_4809)""}]"	"[{""id"": ""RHEA:38472"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 38472 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-011_da507204e973	RHEA:38472	pathwaymech:produces	CHEBI:57856	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38472	Stoichiometric coefficient 3.	"[{""reference_id"": ""RHEA:38472"", ""source_assertion"": ""RHEA:38472 assigns CHEBI:57856 to its products with coefficient 3."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/38472']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/38471_R']/rh:contains3[@rdf:resource='http://rdf.rhea-db.org/Participant_38471_compound_4281']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_4281)""}]"	"[{""id"": ""RHEA:38472"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 38472 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-012_5cabab20be52	RHEA:38472	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38472	Stoichiometric coefficient 3.	"[{""reference_id"": ""RHEA:38472"", ""source_assertion"": ""RHEA:38472 assigns CHEBI:15378 to its products with coefficient 3."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/38472']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/38471_R']/rh:contains3[@rdf:resource='http://rdf.rhea-db.org/Participant_38471_compound_3249']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3249)""}]"	"[{""id"": ""RHEA:38472"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 38472 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-013_f94af9263d0a	CHEBI:58173	pathwaymech:consumes	RHEA:42673	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42673		"[{""reference_id"": ""RHEA:42673"", ""source_assertion"": ""RHEA:42673 assigns CHEBI:58173 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/42673']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/42672_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_42672_compound_1121']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_1121)""}]"	"[{""id"": ""RHEA:42673"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 42673 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-014_cbf685c3b514	CHEBI:15781	pathwaymech:consumes	RHEA:42673	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42673		"[{""reference_id"": ""RHEA:42673"", ""source_assertion"": ""RHEA:42673 assigns CHEBI:15781 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/42673']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/42672_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_42672_compound_4809']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_4809)""}]"	"[{""id"": ""RHEA:42673"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 42673 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-015_9dbf66d86089	CHEBI:15379	pathwaymech:consumes	RHEA:42673	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42673		"[{""reference_id"": ""RHEA:42673"", ""source_assertion"": ""RHEA:42673 assigns CHEBI:15379 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/42673']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/42672_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_42672_compound_1198']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_1198)""}]"	"[{""id"": ""RHEA:42673"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 42673 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-016_67ee82104b05	RHEA:42673	pathwaymech:produces	CHEBI:82703	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42673		"[{""reference_id"": ""RHEA:42673"", ""source_assertion"": ""RHEA:42673 assigns CHEBI:82703 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/42673']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/42672_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_42672_compound_10177']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_10177)""}]"	"[{""id"": ""RHEA:42673"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 42673 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-017_8d1c58ee7b41	RHEA:42673	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42673		"[{""reference_id"": ""RHEA:42673"", ""source_assertion"": ""RHEA:42673 assigns CHEBI:15377 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/42673']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/42672_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_42672_compound_1283']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_1283)""}]"	"[{""id"": ""RHEA:42673"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 42673 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-018_48b82de16457	CHEBI:82703	pathwaymech:consumes	RHEA:42685	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42685		"[{""reference_id"": ""RHEA:42685"", ""source_assertion"": ""RHEA:42685 assigns CHEBI:82703 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/42685']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/42684_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_42684_compound_10177']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_10177)""}]"	"[{""id"": ""RHEA:42685"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 42685 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-019_4067ce74d283	CHEBI:15377	pathwaymech:consumes	RHEA:42685	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42685		"[{""reference_id"": ""RHEA:42685"", ""source_assertion"": ""RHEA:42685 assigns CHEBI:15377 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/42685']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/42684_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_42684_compound_1283']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_1283)""}]"	"[{""id"": ""RHEA:42685"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 42685 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-020_824447ddb9f2	RHEA:42685	pathwaymech:produces	CHEBI:82706	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42685		"[{""reference_id"": ""RHEA:42685"", ""source_assertion"": ""RHEA:42685 assigns CHEBI:82706 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/42685']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/42684_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_42684_compound_10178']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_10178)""}]"	"[{""id"": ""RHEA:42685"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 42685 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-021_ecbaf416cc6c	RHEA:42685	pathwaymech:produces	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:42685		"[{""reference_id"": ""RHEA:42685"", ""source_assertion"": ""RHEA:42685 assigns CHEBI:29985 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/42685']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/42684_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_42684_compound_2079']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_2079)""}]"	"[{""id"": ""RHEA:42685"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 42685 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-022_933453e31c44	CHEBI:82706	pathwaymech:consumes	RHEA:52781	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:52781		"[{""reference_id"": ""RHEA:52781"", ""source_assertion"": ""RHEA:52781 assigns CHEBI:82706 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/52781']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/52780_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_52780_compound_10178']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_10178)""}]"	"[{""id"": ""RHEA:52781"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 52781 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-023_2f3f71971f5f	CHEBI:15377	pathwaymech:consumes	RHEA:52781	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:52781		"[{""reference_id"": ""RHEA:52781"", ""source_assertion"": ""RHEA:52781 assigns CHEBI:15377 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/52781']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/52780_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_52780_compound_1283']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_1283)""}]"	"[{""id"": ""RHEA:52781"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 52781 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-024_4f8886f43340	RHEA:52781	pathwaymech:produces	CHEBI:136834	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:52781		"[{""reference_id"": ""RHEA:52781"", ""source_assertion"": ""RHEA:52781 assigns CHEBI:136834 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/52781']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/52780_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_52780_compound_13362']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_13362)""}]"	"[{""id"": ""RHEA:52781"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 52781 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-025_c68c73486d8e	RHEA:52781	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:52781		"[{""reference_id"": ""RHEA:52781"", ""source_assertion"": ""RHEA:52781 assigns CHEBI:15361 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/52781']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/52780_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_52780_compound_3719']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3719)""}]"	"[{""id"": ""RHEA:52781"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 52781 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-026_c009b98aa26e	RHEA:52781	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:52781		"[{""reference_id"": ""RHEA:52781"", ""source_assertion"": ""RHEA:52781 assigns CHEBI:28938 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/52781']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/52780_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_52780_compound_1012']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_1012)""}]"	"[{""id"": ""RHEA:52781"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 52781 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-027_79671d44d209	CHEBI:136834	pathwaymech:consumes	MetaCyc:RXN-18089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-19388|MetaCyc:RXN-18089		"[{""reference_id"": ""MetaCyc:RXN-18089"", ""source_assertion"": ""The native left side contains CPD-19388 with implicit coefficient 1. The selected equation retains native neutral ergothioneine and no added proton."", ""source_locator"": ""/ptools-xml/Reaction[@frameid='RXN-18089']/left/Compound[@frameid='CPD-19388']; /reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-19388"", ""source_assertion"": ""The sulfenic-acid compound has a CHEBI:136834 unification cross-reference."", ""source_locator"": ""/ptools-xml/Compound/dblink[dblink-db='CHEBI']/dblink-oid""}]"	"[{""id"": ""MetaCyc:CPD-19388"", ""source_sha256"": ""b77e9432355e64fda01dd4a13d385433c7572d6777b44c9a626ae047e42f898d"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""2-(hydroxysulfanyl)hercynine"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-19388""}, {""id"": ""MetaCyc:RXN-18089"", ""source_sha256"": ""1a10cac0c8ba6442c8d774ebc7e7704d5310552770fef3922ca64f564e7ee061"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""RXN-18089"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-18089""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-028_617d40a707ad	CHEBI:17499	pathwaymech:consumes	MetaCyc:RXN-18089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Donor-H2|MetaCyc:RXN-18089		"[{""reference_id"": ""MetaCyc:RXN-18089"", ""source_assertion"": ""The native left side contains Donor-H2 with implicit coefficient 1. The selected equation retains native neutral ergothioneine and no added proton."", ""source_locator"": ""/ptools-xml/Reaction[@frameid='RXN-18089']/left/Compound[@frameid='Donor-H2']; /reaction-direction""}, {""reference_id"": ""MetaCyc:Donor-H2"", ""source_assertion"": ""The native class links CHEBI:17499 and explicitly denotes unknown acceptors transferring two electrons and two protons; its reduced form supplies hydrogen in this reaction."", ""source_locator"": ""/ptools-xml/Compound/dblink[dblink-db='CHEBI']; /ptools-xml/Compound/comment, final paragraph""}]"	"[{""id"": ""MetaCyc:Donor-H2"", ""source_sha256"": ""a2cad5be6b6ec96bc2fabaa2d1d7fbcf0ef6549b846dce6870dd0879ac2e7bb9"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""a reduced electron acceptor"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Donor-H2""}, {""id"": ""MetaCyc:RXN-18089"", ""source_sha256"": ""1a10cac0c8ba6442c8d774ebc7e7704d5310552770fef3922ca64f564e7ee061"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""RXN-18089"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-18089""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-029_c8f96d07daff	MetaCyc:RXN-18089	pathwaymech:produces	CHEBI:4828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Ergothioneine|MetaCyc:RXN-18089		"[{""reference_id"": ""MetaCyc:RXN-18089"", ""source_assertion"": ""The native right side contains Ergothioneine with implicit coefficient 1. The selected equation retains native neutral ergothioneine and no added proton."", ""source_locator"": ""/ptools-xml/Reaction[@frameid='RXN-18089']/right/Compound[@frameid='Ergothioneine']; /reaction-direction""}, {""reference_id"": ""MetaCyc:Ergothioneine"", ""source_assertion"": ""The native neutral ergothioneine structure has a single C-S bond and a CHEBI:4828 cross-reference."", ""source_locator"": ""/ptools-xml/Compound/cml/molecule[@formalCharge='0']/bondArray; /ptools-xml/Compound/dblink[dblink-db='CHEBI']""}]"	"[{""id"": ""MetaCyc:Ergothioneine"", ""source_sha256"": ""574bb36f17a191e57b5018d08daa5bf24f7ce36a006ea660d63cfd0076eb2b81"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""ergothioneine"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Ergothioneine""}, {""id"": ""MetaCyc:RXN-18089"", ""source_sha256"": ""1a10cac0c8ba6442c8d774ebc7e7704d5310552770fef3922ca64f564e7ee061"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""RXN-18089"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-18089""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-030_12cbe0d5882e	MetaCyc:RXN-18089	pathwaymech:produces	CHEBI:13193	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:13193|MetaCyc:Acceptor|MetaCyc:RXN-18089|RHEA:52785		"[{""reference_id"": ""MetaCyc:RXN-18089"", ""source_assertion"": ""The native right side contains Acceptor with implicit coefficient 1. The selected equation retains native neutral ergothioneine and no added proton."", ""source_locator"": ""/ptools-xml/Reaction[@frameid='RXN-18089']/right/Compound[@frameid='Acceptor']; /reaction-direction""}, {""reference_id"": ""MetaCyc:Acceptor"", ""source_assertion"": ""The native oxidized acceptor class is explicitly for unknown acceptors transferring two electrons and two protons; its CHEBI:15339 cross-reference is broader than a formula-bearing hydrogen acceptor."", ""source_locator"": ""/ptools-xml/Compound/comment, final paragraph; /ptools-xml/Compound/dblink[dblink-db='CHEBI']""}, {""reference_id"": ""CHEBI:13193"", ""source_assertion"": ""CHEBI:13193 is the charge-zero formula-A hydrogen acceptor. It provides the formula-bearing generic oxidized partner, without choosing a physiological donor."", ""source_locator"": ""SemanticSQL statements subject CHEBI:13193; rdfs:label, IAO:0000115, chemrof:generalized_empirical_formula, chemrof:charge""}, {""reference_id"": ""RHEA:52785"", ""source_assertion"": ""The independently curated reduction uses CHEBI:17499 as donor and CHEBI:13193 as oxidized partner. Its proton and cationic product convention differs from the selected neutral native equation."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/52785']/rh:substrates and rh:products; participant rh:compound/rh:chebi""}]"	"[{""id"": ""CHEBI:13193"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; source_sha256 covers complete pinned original SemanticSQL database, not the linked HTML page; subject-specific fields inspected"", ""title"": ""hydrogen acceptor"", ""url"": ""https://www.ebi.ac.uk/chebi/CHEBI:13193""}, {""id"": ""MetaCyc:Acceptor"", ""source_sha256"": ""ec1f3b9cc8b8fcc9615706ab317adc59d9117883ce6631a30b8c795f4a3fe19f"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""an oxidized electron acceptor"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Acceptor""}, {""id"": ""MetaCyc:RXN-18089"", ""source_sha256"": ""1a10cac0c8ba6442c8d774ebc7e7704d5310552770fef3922ca64f564e7ee061"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""RXN-18089"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-18089""}, {""id"": ""RHEA:52785"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 52785 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-031_3d9f8af6edc4	MetaCyc:RXN-18089	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-18089		"[{""reference_id"": ""MetaCyc:RXN-18089"", ""source_assertion"": ""The native right side contains WATER with implicit coefficient 1. The selected equation retains native neutral ergothioneine and no added proton."", ""source_locator"": ""/ptools-xml/Reaction[@frameid='RXN-18089']/right/Compound[@frameid='WATER']; /reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-18089"", ""source_sha256"": ""1a10cac0c8ba6442c8d774ebc7e7704d5310552770fef3922ca64f564e7ee061"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""RXN-18089"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-18089""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-032_917203b30274	CHEBI:4828	pathwaymech:consumes	MetaCyc:RXN-15804	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Ergothioneine|MetaCyc:RXN-15804		"[{""reference_id"": ""MetaCyc:RXN-15804"", ""source_assertion"": ""The native right side contains Ergothioneine with implicit coefficient 1. The pathway uses this reversible reaction toward the thione form."", ""source_locator"": ""/ptools-xml/Reaction[@frameid='RXN-15804']/right/Compound[@frameid='Ergothioneine']; /reaction-direction""}, {""reference_id"": ""MetaCyc:Ergothioneine"", ""source_assertion"": ""The native neutral ergothioneine structure has a single C-S bond and a CHEBI:4828 cross-reference."", ""source_locator"": ""/ptools-xml/Compound/cml/molecule[@formalCharge='0']/bondArray; /ptools-xml/Compound/dblink[dblink-db='CHEBI']""}]"	"[{""id"": ""MetaCyc:Ergothioneine"", ""source_sha256"": ""574bb36f17a191e57b5018d08daa5bf24f7ce36a006ea660d63cfd0076eb2b81"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""ergothioneine"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Ergothioneine""}, {""id"": ""MetaCyc:RXN-15804"", ""source_sha256"": ""04281e86c417dd871224bf7445d3d8f4486ed8e690070ba5a623aadedd1bc8f1"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""RXN-15804"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-15804""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-033_b0adb553edc1	MetaCyc:RXN-15804	pathwaymech:produces	CHEBI:82707	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:82707|MetaCyc:Ergothioneine-Thione|MetaCyc:RXN-15804		"[{""reference_id"": ""MetaCyc:RXN-15804"", ""source_assertion"": ""The native left side contains Ergothioneine-Thione with implicit coefficient 1. The pathway uses this reversible reaction toward the thione form."", ""source_locator"": ""/ptools-xml/Reaction[@frameid='RXN-15804']/left/Compound[@frameid='Ergothioneine-Thione']; /reaction-direction""}, {""reference_id"": ""MetaCyc:Ergothioneine-Thione"", ""source_assertion"": ""The native neutral thione has a double bond between sulfur atom15 and carbon atom9. A separate thiol frame participates on the other side."", ""source_locator"": ""/ptools-xml/Compound/cml/molecule[@formalCharge='0']/bondArray/bond[@atomRefs='Ergothioneine-Thione-atom9 Ergothioneine-Thione-atom15']""}, {""reference_id"": ""CHEBI:82707"", ""source_assertion"": ""CHEBI:82707 specifies neutral ergothioneine thione, formula C9H15N3O2S and a C=S SMILES. Its tautomer-normalized standard InChI alone does not distinguish it from thiol CHEBI:4828."", ""source_locator"": ""SemanticSQL statements subject CHEBI:82707; IAO:0000115, chemrof:charge, chemrof:generalized_empirical_formula, chemrof:smiles_string, chemrof:inchi_string""}]"	"[{""id"": ""CHEBI:82707"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; source_sha256 covers complete pinned original SemanticSQL database, not the linked HTML page; subject-specific fields inspected"", ""title"": ""ergothioneine thione form"", ""url"": ""https://www.ebi.ac.uk/chebi/CHEBI:82707""}, {""id"": ""MetaCyc:Ergothioneine-Thione"", ""source_sha256"": ""80824fe40d995355b3eadc8aea033e6fbb20af43346f04c8a24ac2e83589de97"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""ergothioneine (thione form)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Ergothioneine-Thione""}, {""id"": ""MetaCyc:RXN-15804"", ""source_sha256"": ""04281e86c417dd871224bf7445d3d8f4486ed8e690070ba5a623aadedd1bc8f1"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""RXN-15804"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-15804""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-034_bd1a563ad9a0	RHEA:13286	BFO:0000050	MetaCyc:PWY-7255	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLUTCYSLIG-RXN|MetaCyc:PWY-7255|RHEA:13286		"[{""reference_id"": ""MetaCyc:PWY-7255"", ""source_assertion"": ""The complete pathway reaction-list includes GLUTCYSLIG-RXN."", ""source_locator"": ""/ptools-xml/Pathway[@frameid='PWY-7255']/reaction-list/Reaction[@frameid='GLUTCYSLIG-RXN']""}, {""reference_id"": ""MetaCyc:GLUTCYSLIG-RXN"", ""source_assertion"": ""The native reaction has Rhea cross-reference 13286."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:13286"", ""source_assertion"": ""Rhea master 13285 supplies the selected left-to-right reaction RHEA:13286; all chemical sides are taken from that directed record."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13285']/rh:directionalReaction; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13286']/rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:GLUTCYSLIG-RXN"", ""source_sha256"": ""c57a9f06d250ae4aa8c5ce8b5ec13fab90da166ee59f2c37e8480a36c5a91189"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""GLUTCYSLIG-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GLUTCYSLIG-RXN""}, {""id"": ""MetaCyc:PWY-7255"", ""source_sha256"": ""28518a958f37dfa2424c77b5c08db6eb9057e7a26cb61448f4dcbb513ddaf617"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""ergothioneine biosynthesis I (bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7255""}, {""id"": ""RHEA:13286"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 13286 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-035_007a4d2eb316	RHEA:38472	BFO:0000050	MetaCyc:PWY-7255	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7255|MetaCyc:RXN-14431|RHEA:38472		"[{""reference_id"": ""MetaCyc:PWY-7255"", ""source_assertion"": ""The complete pathway reaction-list includes RXN-14431."", ""source_locator"": ""/ptools-xml/Pathway[@frameid='PWY-7255']/reaction-list/Reaction[@frameid='RXN-14431']""}, {""reference_id"": ""MetaCyc:RXN-14431"", ""source_assertion"": ""The native reaction has Rhea cross-reference 38472."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:38472"", ""source_assertion"": ""Rhea master 38471 supplies the selected left-to-right reaction RHEA:38472; all chemical sides are taken from that directed record."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/38471']/rh:directionalReaction; rdf:Description[@rdf:about='http://rdf.rhea-db.org/38472']/rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:PWY-7255"", ""source_sha256"": ""28518a958f37dfa2424c77b5c08db6eb9057e7a26cb61448f4dcbb513ddaf617"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""ergothioneine biosynthesis I (bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7255""}, {""id"": ""MetaCyc:RXN-14431"", ""source_sha256"": ""1a696dc9fa34c88b82b7635f828492e8f199f39f458649ec464a8ae1117a3c22"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""RXN-14431"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-14431""}, {""id"": ""RHEA:38472"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 38472 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-036_8a30fc19eedd	RHEA:42673	BFO:0000050	MetaCyc:PWY-7255	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7255|MetaCyc:RXN-14430|RHEA:42673		"[{""reference_id"": ""MetaCyc:PWY-7255"", ""source_assertion"": ""The complete pathway reaction-list includes RXN-14430."", ""source_locator"": ""/ptools-xml/Pathway[@frameid='PWY-7255']/reaction-list/Reaction[@frameid='RXN-14430']""}, {""reference_id"": ""MetaCyc:RXN-14430"", ""source_assertion"": ""The native reaction has Rhea cross-reference 42673."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:42673"", ""source_assertion"": ""Rhea master 42672 supplies the selected left-to-right reaction RHEA:42673; all chemical sides are taken from that directed record."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/42672']/rh:directionalReaction; rdf:Description[@rdf:about='http://rdf.rhea-db.org/42673']/rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:PWY-7255"", ""source_sha256"": ""28518a958f37dfa2424c77b5c08db6eb9057e7a26cb61448f4dcbb513ddaf617"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""ergothioneine biosynthesis I (bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7255""}, {""id"": ""MetaCyc:RXN-14430"", ""source_sha256"": ""16e76411719bb56fbdfabbffcc317fee6e835f9ea526e1457145b3f928e71396"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""RXN-14430"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-14430""}, {""id"": ""RHEA:42673"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 42673 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-037_8462c063cc31	RHEA:42685	BFO:0000050	MetaCyc:PWY-7255	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7255|MetaCyc:RXN-14429|RHEA:42685		"[{""reference_id"": ""MetaCyc:PWY-7255"", ""source_assertion"": ""The complete pathway reaction-list includes RXN-14429."", ""source_locator"": ""/ptools-xml/Pathway[@frameid='PWY-7255']/reaction-list/Reaction[@frameid='RXN-14429']""}, {""reference_id"": ""MetaCyc:RXN-14429"", ""source_assertion"": ""The native reaction has Rhea cross-reference 42685."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:42685"", ""source_assertion"": ""Rhea master 42684 supplies the selected left-to-right reaction RHEA:42685; all chemical sides are taken from that directed record."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/42684']/rh:directionalReaction; rdf:Description[@rdf:about='http://rdf.rhea-db.org/42685']/rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:PWY-7255"", ""source_sha256"": ""28518a958f37dfa2424c77b5c08db6eb9057e7a26cb61448f4dcbb513ddaf617"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""ergothioneine biosynthesis I (bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7255""}, {""id"": ""MetaCyc:RXN-14429"", ""source_sha256"": ""4d52bf1364015a361c22bc43e5aa4f70d3170afa69a6d6a162dc2858396678fd"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""RXN-14429"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-14429""}, {""id"": ""RHEA:42685"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 42685 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-038_7f12c30d0b65	RHEA:52781	BFO:0000050	MetaCyc:PWY-7255	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7255|MetaCyc:RXN-18088|RHEA:52781		"[{""reference_id"": ""MetaCyc:PWY-7255"", ""source_assertion"": ""The complete pathway reaction-list includes RXN-18088."", ""source_locator"": ""/ptools-xml/Pathway[@frameid='PWY-7255']/reaction-list/Reaction[@frameid='RXN-18088']""}, {""reference_id"": ""MetaCyc:RXN-18088"", ""source_assertion"": ""The native reaction has Rhea cross-reference 52781."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:52781"", ""source_assertion"": ""Rhea master 52780 supplies the selected left-to-right reaction RHEA:52781; all chemical sides are taken from that directed record."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/52780']/rh:directionalReaction; rdf:Description[@rdf:about='http://rdf.rhea-db.org/52781']/rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:PWY-7255"", ""source_sha256"": ""28518a958f37dfa2424c77b5c08db6eb9057e7a26cb61448f4dcbb513ddaf617"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""ergothioneine biosynthesis I (bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7255""}, {""id"": ""MetaCyc:RXN-18088"", ""source_sha256"": ""2a5bc026bc472317241f6a6f10a5bd282f317e61af485341e699418202e0a11f"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""RXN-18088"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-18088""}, {""id"": ""RHEA:52781"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 52781 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-039_af7a32b78f36	MetaCyc:RXN-18089	BFO:0000050	MetaCyc:PWY-7255	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7255|MetaCyc:RXN-18089|PMID:26149121		"[{""reference_id"": ""MetaCyc:PWY-7255"", ""source_assertion"": ""The complete pathway reaction-list includes RXN-18089."", ""source_locator"": ""/ptools-xml/Pathway[@frameid='PWY-7255']/reaction-list/Reaction[@frameid='RXN-18089']""}, {""reference_id"": ""MetaCyc:RXN-18089"", ""source_assertion"": ""The native reaction is annotated spontaneous; its direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""/ptools-xml/Reaction/spontaneous; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""PMID:26149121"", ""source_assertion"": ""With DTT, ergothioneine was the only detected sulfur-containing product of EgtE turnover; without reductant, ergothioneine and sulfinic-acid side product appeared. Potential physiological thiols are suggestions, not identified physiological donors."", ""source_locator"": ""/article/body/sec[@id='sec1']/p[3]; /article/body/sec[@id='sec1']/p[5]; Figure 4""}]"	"[{""id"": ""MetaCyc:PWY-7255"", ""source_sha256"": ""28518a958f37dfa2424c77b5c08db6eb9057e7a26cb61448f4dcbb513ddaf617"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""ergothioneine biosynthesis I (bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7255""}, {""id"": ""MetaCyc:RXN-18089"", ""source_sha256"": ""1a10cac0c8ba6442c8d774ebc7e7704d5310552770fef3922ca64f564e7ee061"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""RXN-18089"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-18089""}, {""id"": ""PMID:26149121"", ""source_sha256"": ""5567e312f5e3fef6298af1b64dfc37ae9675ac8a9f003dcfd898f096d616b125"", ""source_version"": ""Complete original 2015 JATS XML; byte-identical copy of source acquired 2026-10-11T07:45:43.069019+00:00"", ""title"": ""Mechanistic studies of a novel C-S lyase in ergothioneine biosynthesis: the involvement of a sulfenic acid intermediate"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4493562/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-040_7ae478c5576b	MetaCyc:RXN-15804	BFO:0000050	MetaCyc:PWY-7255	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7255|MetaCyc:RXN-15804		"[{""reference_id"": ""MetaCyc:PWY-7255"", ""source_assertion"": ""The complete pathway reaction-list includes RXN-15804."", ""source_locator"": ""/ptools-xml/Pathway[@frameid='PWY-7255']/reaction-list/Reaction[@frameid='RXN-15804']""}, {""reference_id"": ""MetaCyc:RXN-15804"", ""source_assertion"": ""The native reaction is annotated spontaneous; its direction is REVERSIBLE."", ""source_locator"": ""/ptools-xml/Reaction/spontaneous; /ptools-xml/Reaction/reaction-direction""}]"	"[{""id"": ""MetaCyc:PWY-7255"", ""source_sha256"": ""28518a958f37dfa2424c77b5c08db6eb9057e7a26cb61448f4dcbb513ddaf617"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""ergothioneine biosynthesis I (bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7255""}, {""id"": ""MetaCyc:RXN-15804"", ""source_sha256"": ""04281e86c417dd871224bf7445d3d8f4486ed8e690070ba5a623aadedd1bc8f1"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""RXN-15804"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-15804""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-041_301b1d800bad	UniProtKB:A0R5N1	pathwaymech:enables	RHEA:13286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:A0R5N1	EgtA glutamate-cysteine ligase activity is annotated by similarity (ECO:0000250 from P9WPK7), not a direct assay of this mc(2)155 protein.	"[{""reference_id"": ""UniProtKB:A0R5N1"", ""source_assertion"": ""The current entry annotates L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+) with ECO:0000250."", ""source_locator"": ""/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:A0R5N1"", ""source_sha256"": ""d7d0af18a716c43b351213c0b2ad1acada0272ec3661bb1b11ca0c86d424363f"", ""source_version"": ""Complete current original JSON retrieved 2026-10-11; entry version 108, annotation date 2026-06-10; release headers not retained"", ""title"": ""Glutamate--cysteine ligase EgtA"", ""url"": ""https://rest.uniprot.org/uniprotkb/A0R5N1.json""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-042_8e52d256cd17	UniProtKB:A0R5M8	pathwaymech:enables	RHEA:38472	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/ja101721e.s001|PMID:24817736|UniProtKB:A0R5M8	EgtD transfers three SAM methyl groups to histidine; the current entry annotates this activity with ECO:0000269. Primary 2010 and 2014 preparations used DSM43465/ATCC607, not mc(2)155. The earlier engineered preparation differs at residue 2 from the current sequence (A versus T). No functional consequence of this residue difference is inferred.	"[{""reference_id"": ""UniProtKB:A0R5M8"", ""source_assertion"": ""The current entry annotates L-histidine + 3 S-adenosyl-L-methionine = hercynine + 3 S-adenosyl-L-homocysteine + 3 H(+) with ECO:0000269. Its complete current sequence begins MTLSLANY."", ""source_locator"": ""/comments/1/reaction; /sequence/value""}, {""reference_id"": ""DOI:10.1021/ja101721e.s001"", ""source_assertion"": ""The cloned egtB/C/D genes were amplified from M. smegmatis DSM43465 and expressed in E. coli BL21; the selected sections report the relevant reconstituted activity."", ""source_locator"": ""S2-S4, Cloning pS2; Production of EgtB, EgtC and EgtD; EgtD activity""}, {""reference_id"": ""PMID:24817736"", ""source_assertion"": ""The DSM43465/ATCC607 EgtD construct eluted as a monomer by preparative and analytical size-exclusion chromatography; crystal asymmetric-unit multiplicity is not the solution oligomer. The Methods give the tagged construct sequence with a MALSLANY protein start."", ""source_locator"": ""HTML section id='sec2.1', paragraphs 1-2; section id='sec3', paragraph 1""}]"	"[{""id"": ""DOI:10.1021/ja101721e.s001"", ""source_sha256"": ""8865d33ccc48125663acdcf27c5af5e10f1eead72258d95b5270c5e08ad18847"", ""source_version"": ""Original 17-page ACS supplementary PDF; DOI association verified in original Figshare article 2768629"", ""title"": ""In vitro reconstitution of mycobacterial ergothioneine biosynthesis: Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/4462969""}, {""id"": ""PMID:24817736"", ""source_sha256"": ""89ced1b7b2b1aad3ace06e7d0656d79285140ac46293e03f78f19a2a5f4701dd"", ""source_version"": ""Complete original 2014 PMC HTML response; retrieved 2026-10-11"", ""title"": ""Crystallization and preliminary X-ray analysis of the ergothioneine-biosynthetic methyltransferase EgtD"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC4014345/""}, {""id"": ""UniProtKB:A0R5M8"", ""source_sha256"": ""053a1ac9c0b259119666e87d925bfc1fe763220660d2d1549cd78b0d66e9b2ac"", ""source_version"": ""Complete current original JSON retrieved 2026-10-11; entry version 114, annotation date 2026-09-02; release headers not retained"", ""title"": ""Histidine N-alpha-methyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A0R5M8.json""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-043_1d1908d217d3	UniProtKB:A0R5N0	pathwaymech:enables	RHEA:42673	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/ja101721e.s001|UniProtKB:A0R5N0	EgtB oxidative C-S coupling is annotated with ECO:0000269. The 2010 enzyme preparation used DSM43465; the 2015 structural co-citation studies M. thermoresistibile. Neither establishes a mc(2)155 solution assembly.	"[{""reference_id"": ""UniProtKB:A0R5N0"", ""source_assertion"": ""The current entry annotates gamma-L-glutamyl-L-cysteine + hercynine + O2 = gamma-L-glutamyl-hercynylcysteine S-oxide + H2O with ECO:0000269."", ""source_locator"": ""/comments/1/reaction""}, {""reference_id"": ""DOI:10.1021/ja101721e.s001"", ""source_assertion"": ""The cloned egtB/C/D genes were amplified from M. smegmatis DSM43465 and expressed in E. coli BL21; the selected sections report the relevant reconstituted activity."", ""source_locator"": ""S2-S3 and S5-S9, Cloning pS2; EgtB reaction/product and metal/substrate tests""}]"	"[{""id"": ""DOI:10.1021/ja101721e.s001"", ""source_sha256"": ""8865d33ccc48125663acdcf27c5af5e10f1eead72258d95b5270c5e08ad18847"", ""source_version"": ""Original 17-page ACS supplementary PDF; DOI association verified in original Figshare article 2768629"", ""title"": ""In vitro reconstitution of mycobacterial ergothioneine biosynthesis: Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/4462969""}, {""id"": ""UniProtKB:A0R5N0"", ""source_sha256"": ""f97375c162840574c6f33175194749477b3e83d2710bb6e06cf1334491c5fac6"", ""source_version"": ""Complete current original JSON retrieved 2026-10-11; entry version 112, annotation date 2026-09-02; release headers not retained"", ""title"": ""Hercynine oxygenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A0R5N0.json""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-044_3750c457414a	UniProtKB:A0R5M9	pathwaymech:enables	RHEA:42685	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/ja101721e.s001|PMID:26079795|UniProtKB:A0R5M9	EgtC hydrolyses the gamma-glutamyl moiety (ECO:0000269). Functional enables retains its experimentally supported tetramer assembly context; it does not assert isolated-monomer sufficiency.	"[{""reference_id"": ""UniProtKB:A0R5M9"", ""source_assertion"": ""The current entry annotates gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = S-(hercyn-2-yl)-L-cysteine S-oxide + L-glutamate with ECO:0000269."", ""source_locator"": ""/comments/1/reaction""}, {""reference_id"": ""DOI:10.1021/ja101721e.s001"", ""source_assertion"": ""The cloned egtB/C/D genes were amplified from M. smegmatis DSM43465 and expressed in E. coli BL21; the selected sections report the relevant reconstituted activity."", ""source_locator"": ""S2-S3 and S10, Cloning pS2; combined enzymatic ergothioneine synthesis""}, {""reference_id"": ""PMID:26079795"", ""source_assertion"": ""The authors cloned A0R5M9/MSMEG_6248 from mc(2)155/ATCC700084 and report a tetramer supported by PISA and analytical size-exclusion chromatography. Their substrate-bound structure used a C2A variant."", ""source_locator"": ""Accepted manuscript PDF p2, Results and Discussion / Overall structure; pp5-6, Experimental Section / Protein production""}]"	"[{""id"": ""DOI:10.1021/ja101721e.s001"", ""source_sha256"": ""8865d33ccc48125663acdcf27c5af5e10f1eead72258d95b5270c5e08ad18847"", ""source_version"": ""Original 17-page ACS supplementary PDF; DOI association verified in original Figshare article 2768629"", ""title"": ""In vitro reconstitution of mycobacterial ergothioneine biosynthesis: Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/4462969""}, {""id"": ""PMID:26079795"", ""source_sha256"": ""6e7a43aa9e761c39b86386355b6ca1e2b2005ba9674ad41b280265fe1aea344e"", ""source_version"": ""Complete 9-page accepted author manuscript; manuscript PDF, not typeset version of record; retrieved 2026-10-11"", ""title"": ""Structure of the ergothioneine-biosynthetic amidohydrolase EgtC"", ""url"": ""https://edoc.unibas.ch/server/api/core/bitstreams/44f1dafa-678e-46a7-9af2-115c7131537b/content""}, {""id"": ""UniProtKB:A0R5M9"", ""source_sha256"": ""8ff51001db45c43c402528f31fd4188f7a1af9bedacf28d104ced68e7424ae98"", ""source_version"": ""Complete current original JSON retrieved 2026-10-11; entry version 103, annotation date 2026-06-10; release headers not retained"", ""title"": ""Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A0R5M9.json""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-045_62a4500c457c	UniProtKB:A0R5M7	pathwaymech:enables	RHEA:52781	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:26149121|PMID:38072054|UniProtKB:A0R5M7	EgtE cleavage produces sulfenohercynine, pyruvate and ammonium (ECO:0000269). Functional enables retains the solution-supported homodimer; subsequent reduction is not assigned as a separate EgtE catalytic reaction.	"[{""reference_id"": ""UniProtKB:A0R5M7"", ""source_assertion"": ""The current entry annotates S-(hercyn-2-yl)-L-cysteine S-oxide + H2O = 2-sulfenohercynine + pyruvate + NH4(+) with ECO:0000269."", ""source_locator"": ""/comments/2/reaction""}, {""reference_id"": ""PMID:26149121"", ""source_assertion"": ""The purified PLP enzyme converted the sulfoxide to a trapped sulfenic-acid intermediate; DTT yielded ergothioneine with pyruvate and ammonia. The particular physiological reductant was not established."", ""source_locator"": ""/article/body/sec[@id='sec1']/p[position()>=3 and position()<=8]; Figures 4-6""}, {""reference_id"": ""PMID:38072054"", ""source_assertion"": ""The full A0R5M7/MSMEG_6246 coding region came from mc2155. Crystal and solution chromatography support a homodimer; the substrate pocket includes residues from the neighboring monomer."", ""source_locator"": ""/article/body/sec[@id='sec3']/sec[@id='sec3.2']/p[1]; /article/body/sec[@id='sec1']/sec[@id='sec1.1']/p[2]; sec[@id='sec1.2']/p[1]""}]"	"[{""id"": ""PMID:26149121"", ""source_sha256"": ""5567e312f5e3fef6298af1b64dfc37ae9675ac8a9f003dcfd898f096d616b125"", ""source_version"": ""Complete original 2015 JATS XML; byte-identical copy of source acquired 2026-10-11T07:45:43.069019+00:00"", ""title"": ""Mechanistic studies of a novel C-S lyase in ergothioneine biosynthesis: the involvement of a sulfenic acid intermediate"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4493562/fullTextXML""}, {""id"": ""PMID:38072054"", ""source_sha256"": ""d9c105c4d6b82abfba24f236558d6cd1719ae8cb1b5e7657acc2cf88864583ad"", ""source_version"": ""Complete original JATS XML; article published 2023, collection 2024; retrieved 2026-10-11"", ""title"": ""Structure of mycobacterial ergothioneine-biosynthesis C-S lyase EgtE"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10805701/fullTextXML""}, {""id"": ""UniProtKB:A0R5M7"", ""source_sha256"": ""46f0cb1228117778bb4ee9e883495e5bb39cc9837016ebf3973dd953d5796d3a"", ""source_version"": ""Complete current original JSON retrieved 2026-10-11; entry version 111, annotation date 2026-09-02; release headers not retained"", ""title"": ""Hercynylcysteine sulfoxide lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A0R5M7.json""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-046_eafeec5b52ed	UniProtKB:A0R5N0	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/ja101721e.s001|UniProtKB:A0R5N0		"[{""reference_id"": ""UniProtKB:A0R5N0"", ""source_assertion"": ""Fe(2+) is annotated as EgtB cofactor with ECO:0000269 evidence."", ""source_locator"": ""/comments/2/cofactors/0""}, {""reference_id"": ""DOI:10.1021/ja101721e.s001"", ""source_assertion"": ""Chelex treatment reduced activity of the DSM43465 EgtB preparation; FeSO4 restored sulfoxide formation, unlike the tested Zn, Cu or Mn conditions."", ""source_locator"": ""S7, Figure S6 and paragraph describing metal depletion/reconstitution""}]"	"[{""id"": ""DOI:10.1021/ja101721e.s001"", ""source_sha256"": ""8865d33ccc48125663acdcf27c5af5e10f1eead72258d95b5270c5e08ad18847"", ""source_version"": ""Original 17-page ACS supplementary PDF; DOI association verified in original Figshare article 2768629"", ""title"": ""In vitro reconstitution of mycobacterial ergothioneine biosynthesis: Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/4462969""}, {""id"": ""UniProtKB:A0R5N0"", ""source_sha256"": ""f97375c162840574c6f33175194749477b3e83d2710bb6e06cf1334491c5fac6"", ""source_version"": ""Complete current original JSON retrieved 2026-10-11; entry version 112, annotation date 2026-09-02; release headers not retained"", ""title"": ""Hercynine oxygenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A0R5N0.json""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-047_d0b01250d0b3	UniProtKB:A0R5M7	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:26149121|UniProtKB:A0R5M7		"[{""reference_id"": ""UniProtKB:A0R5M7"", ""source_assertion"": ""Pyridoxal 5'-phosphate is annotated as EgtE cofactor with ECO:0000269."", ""source_locator"": ""/comments/3/cofactors/0""}, {""reference_id"": ""PMID:26149121"", ""source_assertion"": ""Purified EgtE displayed a PLP-associated 420 nm absorbance and contained approximately 0.8 mol PLP per mol enzyme monomer."", ""source_locator"": ""/article/body/sec[@id='sec1']/p[1]""}]"	"[{""id"": ""PMID:26149121"", ""source_sha256"": ""5567e312f5e3fef6298af1b64dfc37ae9675ac8a9f003dcfd898f096d616b125"", ""source_version"": ""Complete original 2015 JATS XML; byte-identical copy of source acquired 2026-10-11T07:45:43.069019+00:00"", ""title"": ""Mechanistic studies of a novel C-S lyase in ergothioneine biosynthesis: the involvement of a sulfenic acid intermediate"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4493562/fullTextXML""}, {""id"": ""UniProtKB:A0R5M7"", ""source_sha256"": ""46f0cb1228117778bb4ee9e883495e5bb39cc9837016ebf3973dd953d5796d3a"", ""source_version"": ""Complete current original JSON retrieved 2026-10-11; entry version 111, annotation date 2026-09-02; release headers not retained"", ""title"": ""Hercynylcysteine sulfoxide lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A0R5M7.json""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-049_2a517c12c8bc	UniProtKB:A0R5M8	pathwaymech:enables	MetaCyc:PWY-7255	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:23629716		"[{""reference_id"": ""PMID:23629716"", ""source_assertion"": ""M. smegmatis mc2155 lacking egtD lost detectable ergothioneine synthesis; complementation restored production. This establishes pathway physiology, not direct validation of all seven individual reaction states."", ""source_locator"": ""HTML section id='sec5', paragraph 1; section id='sec12', paragraph 1; Table 3""}]"	"[{""id"": ""PMID:23629716"", ""source_sha256"": ""6551e9000cd0f815c48f5d55f827aae32a05094f92c2ebdaecbee94f59c12e61"", ""source_version"": ""Complete original 2013 PMC HTML response; retrieved 2026-10-11"", ""title"": ""Ergothioneine is a secreted antioxidant in Mycobacterium smegmatis"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3697313/""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-050_bc1ebf320a8f	RHEA:13286	RO:0002413	RHEA:42673	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7255|RHEA:13286|RHEA:42673	Shared chemical: CHEBI:58173.	"[{""reference_id"": ""MetaCyc:PWY-7255"", ""source_assertion"": ""Native reaction ordering and layout connect GLUTCYSLIG-RXN to RXN-14430."", ""source_locator"": ""/ptools-xml/Pathway/reaction-ordering; /ptools-xml/Pathway/reaction-layout[Reaction/@frameid='GLUTCYSLIG-RXN' or Reaction/@frameid='RXN-14430']""}, {""reference_id"": ""RHEA:13286"", ""source_assertion"": ""RHEA:13286 assigns CHEBI:58173 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13286']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13285_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13285_compound_1121']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_1121)""}, {""reference_id"": ""RHEA:42673"", ""source_assertion"": ""RHEA:42673 assigns CHEBI:58173 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/42673']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/42672_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_42672_compound_1121']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_1121)""}]"	"[{""id"": ""MetaCyc:PWY-7255"", ""source_sha256"": ""28518a958f37dfa2424c77b5c08db6eb9057e7a26cb61448f4dcbb513ddaf617"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""ergothioneine biosynthesis I (bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7255""}, {""id"": ""RHEA:13286"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 13286 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:42673"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 42673 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-051_e9a043a87c37	RHEA:38472	RO:0002413	RHEA:42673	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7255|RHEA:38472|RHEA:42673	Shared chemical: CHEBI:15781.	"[{""reference_id"": ""MetaCyc:PWY-7255"", ""source_assertion"": ""Native reaction ordering and layout connect RXN-14431 to RXN-14430."", ""source_locator"": ""/ptools-xml/Pathway/reaction-ordering; /ptools-xml/Pathway/reaction-layout[Reaction/@frameid='RXN-14431' or Reaction/@frameid='RXN-14430']""}, {""reference_id"": ""RHEA:38472"", ""source_assertion"": ""RHEA:38472 assigns CHEBI:15781 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/38472']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/38471_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_38471_compound_4809']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_4809)""}, {""reference_id"": ""RHEA:42673"", ""source_assertion"": ""RHEA:42673 assigns CHEBI:15781 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/42673']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/42672_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_42672_compound_4809']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_4809)""}]"	"[{""id"": ""MetaCyc:PWY-7255"", ""source_sha256"": ""28518a958f37dfa2424c77b5c08db6eb9057e7a26cb61448f4dcbb513ddaf617"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""ergothioneine biosynthesis I (bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7255""}, {""id"": ""RHEA:38472"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 38472 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:42673"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 42673 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-052_db0d15b93a8c	RHEA:42673	RO:0002413	RHEA:42685	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7255|RHEA:42673|RHEA:42685	Shared chemical: CHEBI:82703.	"[{""reference_id"": ""MetaCyc:PWY-7255"", ""source_assertion"": ""Native reaction ordering and layout connect RXN-14430 to RXN-14429."", ""source_locator"": ""/ptools-xml/Pathway/reaction-ordering; /ptools-xml/Pathway/reaction-layout[Reaction/@frameid='RXN-14430' or Reaction/@frameid='RXN-14429']""}, {""reference_id"": ""RHEA:42673"", ""source_assertion"": ""RHEA:42673 assigns CHEBI:82703 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/42673']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/42672_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_42672_compound_10177']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_10177)""}, {""reference_id"": ""RHEA:42685"", ""source_assertion"": ""RHEA:42685 assigns CHEBI:82703 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/42685']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/42684_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_42684_compound_10177']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_10177)""}]"	"[{""id"": ""MetaCyc:PWY-7255"", ""source_sha256"": ""28518a958f37dfa2424c77b5c08db6eb9057e7a26cb61448f4dcbb513ddaf617"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""ergothioneine biosynthesis I (bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7255""}, {""id"": ""RHEA:42673"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 42673 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:42685"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 42685 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-053_ff5cbc9bdc0e	RHEA:42685	RO:0002413	RHEA:52781	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7255|RHEA:42685|RHEA:52781	Shared chemical: CHEBI:82706.	"[{""reference_id"": ""MetaCyc:PWY-7255"", ""source_assertion"": ""Native reaction ordering and layout connect RXN-14429 to RXN-18088."", ""source_locator"": ""/ptools-xml/Pathway/reaction-ordering; /ptools-xml/Pathway/reaction-layout[Reaction/@frameid='RXN-14429' or Reaction/@frameid='RXN-18088']""}, {""reference_id"": ""RHEA:42685"", ""source_assertion"": ""RHEA:42685 assigns CHEBI:82706 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/42685']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/42684_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_42684_compound_10178']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_10178)""}, {""reference_id"": ""RHEA:52781"", ""source_assertion"": ""RHEA:52781 assigns CHEBI:82706 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/52781']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/52780_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_52780_compound_10178']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_10178)""}]"	"[{""id"": ""MetaCyc:PWY-7255"", ""source_sha256"": ""28518a958f37dfa2424c77b5c08db6eb9057e7a26cb61448f4dcbb513ddaf617"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""ergothioneine biosynthesis I (bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7255""}, {""id"": ""RHEA:42685"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 42685 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:52781"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 52781 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-054_d5d678259c9b	RHEA:52781	RO:0002413	MetaCyc:RXN-18089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-19388|MetaCyc:PWY-7255|MetaCyc:RXN-18089|RHEA:52781	Shared chemical: CHEBI:136834.	"[{""reference_id"": ""MetaCyc:PWY-7255"", ""source_assertion"": ""Native reaction ordering and layout connect RXN-18088 to RXN-18089."", ""source_locator"": ""/ptools-xml/Pathway/reaction-ordering; /ptools-xml/Pathway/reaction-layout[Reaction/@frameid='RXN-18088' or Reaction/@frameid='RXN-18089']""}, {""reference_id"": ""RHEA:52781"", ""source_assertion"": ""RHEA:52781 assigns CHEBI:136834 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/52781']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/52780_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_52780_compound_13362']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_13362)""}, {""reference_id"": ""MetaCyc:RXN-18089"", ""source_assertion"": ""The native left side contains CPD-19388 with implicit coefficient 1. The selected equation retains native neutral ergothioneine and no added proton."", ""source_locator"": ""/ptools-xml/Reaction[@frameid='RXN-18089']/left/Compound[@frameid='CPD-19388']; /reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-19388"", ""source_assertion"": ""The sulfenic-acid compound has a CHEBI:136834 unification cross-reference."", ""source_locator"": ""/ptools-xml/Compound/dblink[dblink-db='CHEBI']/dblink-oid""}]"	"[{""id"": ""MetaCyc:CPD-19388"", ""source_sha256"": ""b77e9432355e64fda01dd4a13d385433c7572d6777b44c9a626ae047e42f898d"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""2-(hydroxysulfanyl)hercynine"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-19388""}, {""id"": ""MetaCyc:PWY-7255"", ""source_sha256"": ""28518a958f37dfa2424c77b5c08db6eb9057e7a26cb61448f4dcbb513ddaf617"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""ergothioneine biosynthesis I (bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7255""}, {""id"": ""MetaCyc:RXN-18089"", ""source_sha256"": ""1a10cac0c8ba6442c8d774ebc7e7704d5310552770fef3922ca64f564e7ee061"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""RXN-18089"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-18089""}, {""id"": ""RHEA:52781"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 52781 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7255_ergothioneine-edge-055_4705288219b2	MetaCyc:RXN-18089	RO:0002413	MetaCyc:RXN-15804	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Ergothioneine|MetaCyc:PWY-7255|MetaCyc:RXN-15804|MetaCyc:RXN-18089	Shared chemical: CHEBI:4828.	"[{""reference_id"": ""MetaCyc:PWY-7255"", ""source_assertion"": ""Native reaction ordering and layout connect RXN-18089 to RXN-15804."", ""source_locator"": ""/ptools-xml/Pathway/reaction-ordering; /ptools-xml/Pathway/reaction-layout[Reaction/@frameid='RXN-18089' or Reaction/@frameid='RXN-15804']""}, {""reference_id"": ""MetaCyc:RXN-18089"", ""source_assertion"": ""The native right side contains Ergothioneine with implicit coefficient 1. The selected equation retains native neutral ergothioneine and no added proton."", ""source_locator"": ""/ptools-xml/Reaction[@frameid='RXN-18089']/right/Compound[@frameid='Ergothioneine']; /reaction-direction""}, {""reference_id"": ""MetaCyc:Ergothioneine"", ""source_assertion"": ""The native neutral ergothioneine structure has a single C-S bond and a CHEBI:4828 cross-reference."", ""source_locator"": ""/ptools-xml/Compound/cml/molecule[@formalCharge='0']/bondArray; /ptools-xml/Compound/dblink[dblink-db='CHEBI']""}, {""reference_id"": ""MetaCyc:RXN-15804"", ""source_assertion"": ""The native right side contains Ergothioneine with implicit coefficient 1. The pathway uses this reversible reaction toward the thione form."", ""source_locator"": ""/ptools-xml/Reaction[@frameid='RXN-15804']/right/Compound[@frameid='Ergothioneine']; /reaction-direction""}, {""reference_id"": ""MetaCyc:Ergothioneine"", ""source_assertion"": ""The native neutral ergothioneine structure has a single C-S bond and a CHEBI:4828 cross-reference."", ""source_locator"": ""/ptools-xml/Compound/cml/molecule[@formalCharge='0']/bondArray; /ptools-xml/Compound/dblink[dblink-db='CHEBI']""}]"	"[{""id"": ""MetaCyc:Ergothioneine"", ""source_sha256"": ""574bb36f17a191e57b5018d08daa5bf24f7ce36a006ea660d63cfd0076eb2b81"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""ergothioneine"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Ergothioneine""}, {""id"": ""MetaCyc:PWY-7255"", ""source_sha256"": ""28518a958f37dfa2424c77b5c08db6eb9057e7a26cb61448f4dcbb513ddaf617"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""ergothioneine biosynthesis I (bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7255""}, {""id"": ""MetaCyc:RXN-15804"", ""source_sha256"": ""04281e86c417dd871224bf7445d3d8f4486ed8e690070ba5a623aadedd1bc8f1"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""RXN-15804"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-15804""}, {""id"": ""MetaCyc:RXN-18089"", ""source_sha256"": ""1a10cac0c8ba6442c8d774ebc7e7704d5310552770fef3922ca64f564e7ee061"", ""source_version"": ""MetaCyc 22.5 public mirror; complete original XML response retrieved 2026-10-11"", ""title"": ""RXN-18089"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-18089""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-001_0664989d5535	SGD:S000004143	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4300/6a4c244800003293	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003293 RO:0002333 gomodel:YeastPathways_PWY3O-4300/6a4c244800003300."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/0; endpoint types: /individuals/48/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-004_44c802cf5064	gomodel:ALCOHOL-DEHYDROG-RXN	RO:0002234	CHEBI:15343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:ALCOHOL-DEHYDROG-RXN RO:0002234 gomodel:CHEBI_15343_ALCOHOL-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/3; endpoint types: /individuals/1/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-005_e08584c029f4	SGD:S000004918	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4300/6a4c244800003312	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003312 RO:0002333 gomodel:YeastPathways_PWY3O-4300/6a4c244800003321."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/4; endpoint types: /individuals/66/type; /individuals/71/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-006_573c66ae5a9d	gomodel:RXN66-3	RO:0002413	gomodel:YeastPathways_PWY3O-4300/6a4c244800003293	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:RXN66-3 RO:0002413 gomodel:YeastPathways_PWY3O-4300/6a4c244800003293."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/5; endpoint types: /individuals/17/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-007_6cba048a9cc0	gomodel:YeastPathways_PWY3O-4300/6a4c244800003332	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003332 RO:0002234 gomodel:YeastPathways_PWY3O-4300/6a4c244800003336."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/6; endpoint types: /individuals/82/type; /individuals/86/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-008_1feacf59295c	gomodel:ALCOHOL-DEHYDROG-RXN	RO:0002413	gomodel:RXN66-3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:ALCOHOL-DEHYDROG-RXN RO:0002413 gomodel:RXN66-3."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/7; endpoint types: /individuals/1/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-009_8e8418531fba	gomodel:RXN66-3	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:RXN66-3 RO:0002234 gomodel:CHEBI_57945_RXN66-3."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/8; endpoint types: /individuals/17/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-010_02d0a4a7552b	gomodel:RXN66-3	RO:0002234	CHEBI:30089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:RXN66-3 RO:0002234 gomodel:CHEBI_30089_RXN66-3."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/9; endpoint types: /individuals/17/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-011_2ade6ea2fdef	gomodel:ACETATE--COA-LIGASE-RXN	RO:0002233	CHEBI:30089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:ACETATE--COA-LIGASE-RXN RO:0002233 gomodel:CHEBI_30089_RXN66-3."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/10; endpoint types: /individuals/0/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-014_6ac0c589bff1	gomodel:ACETATE--COA-LIGASE-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:ACETATE--COA-LIGASE-RXN RO:0002234 gomodel:CHEBI_29888_ACETATE--COA-LIGASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/13; endpoint types: /individuals/0/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-015_1094417f9f38	gomodel:YeastPathways_PWY3O-4300/6a4c244800003332	RO:0002233	CHEBI:16236	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003332 RO:0002233 gomodel:YeastPathways_PWY3O-4300/6a4c244800003334."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/14; endpoint types: /individuals/82/type; /individuals/84/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-016_fc53a8bacad3	gomodel:YeastPathways_PWY3O-4300/6a4c244800003332	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003332 RO:0002233 gomodel:YeastPathways_PWY3O-4300/6a4c244800003333."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/15; endpoint types: /individuals/82/type; /individuals/83/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-017_b37fd6f89496	gomodel:RXN66-3	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:RXN66-3 RO:0002233 gomodel:CHEBI_57540_RXN66-3."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/16; endpoint types: /individuals/17/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-018_5515f5e2fb9c	gomodel:YeastPathways_PWY3O-4300/6a4c244800003312	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003312 RO:0002234 gomodel:YeastPathways_PWY3O-4300/6a4c244800003315."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/17; endpoint types: /individuals/66/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-020_021da4f49a39	gomodel:RXN66-3	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:RXN66-3 RO:0002234 gomodel:CHEBI_15378_RXN66-3."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/19; endpoint types: /individuals/17/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-022_db022ac14aa6	gomodel:ALCOHOL-DEHYDROG-RXN	BFO:0000050	GO:0006068	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:ALCOHOL-DEHYDROG-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4300/YeastPathways_PWY3O-4300."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/21; endpoint types: /individuals/1/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-023_135c7c72335c	gomodel:YeastPathways_PWY3O-4300/6a4c244800003312	RO:0002234	CHEBI:15343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003312 RO:0002234 gomodel:CHEBI_15343_ALCOHOL-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/22; endpoint types: /individuals/66/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-025_a37e78433c92	gomodel:ALCOHOL-DEHYDROG-RXN	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:ALCOHOL-DEHYDROG-RXN RO:0002233 gomodel:CHEBI_57540_ALCOHOL-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/24; endpoint types: /individuals/1/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-026_2aadc7f737f0	gomodel:YeastPathways_PWY3O-4300/6a4c244800003293	RO:0002234	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003293 RO:0002234 gomodel:YeastPathways_PWY3O-4300/6a4c244800003298."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/25; endpoint types: /individuals/48/type; /individuals/53/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-027_3ff57254ecd0	gomodel:ACETATE--COA-LIGASE-RXN	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:ACETATE--COA-LIGASE-RXN RO:0002234 gomodel:CHEBI_456215_ACETATE--COA-LIGASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/26; endpoint types: /individuals/0/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-028_5056d6442c8f	gomodel:RXN66-3	RO:0002413	gomodel:ACETATE--COA-LIGASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:RXN66-3 RO:0002413 gomodel:ACETATE--COA-LIGASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/27; endpoint types: /individuals/17/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-029_913ba2290e91	gomodel:ACETATE--COA-LIGASE-RXN	RO:0002234	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:ACETATE--COA-LIGASE-RXN RO:0002234 gomodel:CHEBI_57288_ACETATE--COA-LIGASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/28; endpoint types: /individuals/0/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-030_b366c70c8432	gomodel:YeastPathways_PWY3O-4300/6a4c244800003332	BFO:0000050	GO:0006068	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003332 BFO:0000050 gomodel:YeastPathways_PWY3O-4300/YeastPathways_PWY3O-4300."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/29; endpoint types: /individuals/82/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-031_088973ef83ad	gomodel:RXN66-3	RO:0002233	CHEBI:15343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:RXN66-3 RO:0002233 gomodel:CHEBI_15343_ALCOHOL-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/30; endpoint types: /individuals/17/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-032_47de4771c190	gomodel:ACETATE--COA-LIGASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:ACETATE--COA-LIGASE-RXN BFO:0000066 gomodel:reaction_ACETATE--COA-LIGASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/31; endpoint types: /individuals/0/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-033_1011f7940215	gomodel:RXN66-3	BFO:0000050	GO:0006068	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:RXN66-3 BFO:0000050 gomodel:YeastPathways_PWY3O-4300/YeastPathways_PWY3O-4300."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/32; endpoint types: /individuals/17/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-034_2f42bde926d3	gomodel:YeastPathways_PWY3O-4300/6a4c244800003293	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003293 RO:0002233 gomodel:YeastPathways_PWY3O-4300/6a4c244800003295."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/33; endpoint types: /individuals/48/type; /individuals/50/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-035_a19eeb778521	gomodel:ACETATE--COA-LIGASE-RXN	RO:0002233	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:ACETATE--COA-LIGASE-RXN RO:0002233 gomodel:CHEBI_57287_ACETATE--COA-LIGASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/34; endpoint types: /individuals/0/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-036_7798e80ff7c9	gomodel:YeastPathways_PWY3O-4300/6a4c244800003293	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003293 RO:0002234 gomodel:YeastPathways_PWY3O-4300/6a4c244800003296."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/35; endpoint types: /individuals/48/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-038_cc27cc6f0184	gomodel:YeastPathways_PWY3O-4300/6a4c244800003332	RO:0002234	CHEBI:15343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003332 RO:0002234 gomodel:CHEBI_15343_ALCOHOL-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/37; endpoint types: /individuals/82/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-040_1de6df75bc8c	gomodel:ACETATE--COA-LIGASE-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:ACETATE--COA-LIGASE-RXN RO:0002233 gomodel:CHEBI_30616_ACETATE--COA-LIGASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/39; endpoint types: /individuals/0/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-041_870f5b14d12e	gomodel:ALCOHOL-DEHYDROG-RXN	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:ALCOHOL-DEHYDROG-RXN RO:0002234 gomodel:CHEBI_57945_ALCOHOL-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/40; endpoint types: /individuals/1/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-042_d38bce3b2f69	gomodel:ALCOHOL-DEHYDROG-RXN	RO:0002233	CHEBI:16236	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:ALCOHOL-DEHYDROG-RXN RO:0002233 gomodel:CHEBI_16236_ALCOHOL-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/41; endpoint types: /individuals/1/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-043_1d7381714a0d	gomodel:YeastPathways_PWY3O-4300/6a4c244800003293	RO:0002233	CHEBI:30089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003293 RO:0002233 gomodel:CHEBI_30089_RXN66-3."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/42; endpoint types: /individuals/48/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-044_fc6ccc66265a	SGD:S000004780	pathwaymech:enables	gomodel:RXN66-3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:RXN66-3 RO:0002333 gomodel:YeastPathways_PWY3O-4300/6690711d00000772."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/43; endpoint types: /individuals/17/type; /individuals/130/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-045_3fea7f154c0f	gomodel:YeastPathways_PWY3O-4300/6a4c244800003332	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003332 RO:0002234 gomodel:YeastPathways_PWY3O-4300/6a4c244800003335."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/44; endpoint types: /individuals/82/type; /individuals/85/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-047_2a08e68b3baf	gomodel:YeastPathways_PWY3O-4300/6a4c244800003312	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003312 BFO:0000066 gomodel:YeastPathways_PWY3O-4300/6a4c244800003322."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/46; endpoint types: /individuals/66/type; /individuals/72/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-048_5e1482cb29a1	gomodel:ACETATE--COA-LIGASE-RXN	BFO:0000050	GO:0006068	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:ACETATE--COA-LIGASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4300/YeastPathways_PWY3O-4300."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/47; endpoint types: /individuals/0/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-049_8edcb5e88944	gomodel:YeastPathways_PWY3O-4300/6a4c244800003293	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003293 BFO:0000066 gomodel:YeastPathways_PWY3O-4300/6a4c244800003301."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/48; endpoint types: /individuals/48/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-050_c139ae376618	gomodel:YeastPathways_PWY3O-4300/6a4c244800003332	RO:0002413	gomodel:RXN66-3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003332 RO:0002413 gomodel:RXN66-3."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/49; endpoint types: /individuals/82/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-051_57096549a9e7	SGD:S000005446	pathwaymech:enables	gomodel:ALCOHOL-DEHYDROG-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:ALCOHOL-DEHYDROG-RXN RO:0002333 gomodel:YOL086C-MONOMER_ALCOHOL-DEHYDROG-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/50; endpoint types: /individuals/1/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-053_f8302ea044c9	SGD:S000004688	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4300/6a4c244800003332	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003332 RO:0002333 gomodel:YeastPathways_PWY3O-4300/6a4c244800003339."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/52; endpoint types: /individuals/82/type; /individuals/87/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-054_ce60181ba295	gomodel:ALCOHOL-DEHYDROG-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:ALCOHOL-DEHYDROG-RXN RO:0002234 gomodel:CHEBI_15378_ALCOHOL-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/53; endpoint types: /individuals/1/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-055_cabd684763e2	gomodel:YeastPathways_PWY3O-4300/6a4c244800003312	RO:0002413	gomodel:RXN66-3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003312 RO:0002413 gomodel:RXN66-3."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/54; endpoint types: /individuals/66/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-057_e987cf094212	gomodel:YeastPathways_PWY3O-4300/6a4c244800003312	RO:0002233	CHEBI:16236	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003312 RO:0002233 gomodel:YeastPathways_PWY3O-4300/6a4c244800003314."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/56; endpoint types: /individuals/66/type; /individuals/68/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-058_63f50060d7b8	gomodel:YeastPathways_PWY3O-4300/6a4c244800003312	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003312 RO:0002234 gomodel:YeastPathways_PWY3O-4300/6a4c244800003316."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/57; endpoint types: /individuals/66/type; /individuals/70/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-059_b5172f4dc97c	gomodel:RXN66-3	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:RXN66-3 RO:0002233 gomodel:CHEBI_15377_RXN66-3."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/58; endpoint types: /individuals/17/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-060_3dffb4bec5f3	gomodel:YeastPathways_PWY3O-4300/6a4c244800003312	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003312 RO:0002233 gomodel:YeastPathways_PWY3O-4300/6a4c244800003313."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/59; endpoint types: /individuals/66/type; /individuals/67/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-062_fcaa9f8ed72d	gomodel:ALCOHOL-DEHYDROG-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:ALCOHOL-DEHYDROG-RXN BFO:0000066 gomodel:reaction_ALCOHOL-DEHYDROG-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/61; endpoint types: /individuals/1/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-065_cae4d6e3915e	SGD:S000000050	pathwaymech:enables	gomodel:ACETATE--COA-LIGASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:ACETATE--COA-LIGASE-RXN RO:0002333 gomodel:YAL054C-MONOMER_ACETATE--COA-LIGASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/64; endpoint types: /individuals/0/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-068_0ab265cff8ef	gomodel:YeastPathways_PWY3O-4300/6a4c244800003312	BFO:0000050	GO:0006068	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003312 BFO:0000050 gomodel:YeastPathways_PWY3O-4300/YeastPathways_PWY3O-4300."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/67; endpoint types: /individuals/66/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-070_bcfd1adee1f4	gomodel:YeastPathways_PWY3O-4300/6a4c244800003293	RO:0002233	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003293 RO:0002233 gomodel:YeastPathways_PWY3O-4300/6a4c244800003294."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/69; endpoint types: /individuals/48/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-072_9f52d53e644e	gomodel:YeastPathways_PWY3O-4300/6a4c244800003293	BFO:0000050	GO:0006068	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003293 BFO:0000050 gomodel:YeastPathways_PWY3O-4300/YeastPathways_PWY3O-4300."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/71; endpoint types: /individuals/48/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-073_9f8e11b0bed2	gomodel:RXN66-3	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:RXN66-3 BFO:0000066 gomodel:reaction_RXN66-3_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/72; endpoint types: /individuals/17/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_edge-074_c0df44fd3a62	gomodel:YeastPathways_PWY3O-4300/6a4c244800003293	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4300		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003293 RO:0002234 gomodel:YeastPathways_PWY3O-4300/6a4c244800003297."", ""source_locator"": ""./YeastPathways_PWY3O-4300.json#/facts/73; endpoint types: /individuals/48/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4300"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json"", ""title"": ""SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_location-5400ff38586f_89d7e7b7192b	SGD:S000004143	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P52910	Physical protein location from reviewed UniProt. evidence code not specified by source Source qualification: Predominantly nuclear	"[{""reference_id"": ""UniProtKB:P52910"", ""source_assertion"": ""UniProtKB:P52910 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2080/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P52910"", ""source_assertion"": ""UniProtKB:P52910 has the exact SGD cross-reference SGD:S000004143."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2080/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P52910"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P52910 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_location-ffad779418cf_464505ac547b	SGD:S000004143	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P52910	Physical protein location from reviewed UniProt. evidence code not specified by source Source qualification: Predominantly nuclear	"[{""reference_id"": ""UniProtKB:P52910"", ""source_assertion"": ""UniProtKB:P52910 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2080/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P52910"", ""source_assertion"": ""UniProtKB:P52910 has the exact SGD cross-reference SGD:S000004143."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2080/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P52910"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P52910 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_location-83d9f7cee755_7595d657bfb8	SGD:S000004918	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00331	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:2937632)	"[{""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00331"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00331 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_location-3b70e1ade62c_070b0e27c652	SGD:S000004780	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47771	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11914276)	"[{""reference_id"": ""UniProtKB:P47771"", ""source_assertion"": ""UniProtKB:P47771 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3891/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P47771"", ""source_assertion"": ""UniProtKB:P47771 has the exact SGD cross-reference SGD:S000004780."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3891/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P47771"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47771 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_location-7f1495b92dc9_c5b19c7df683	SGD:S000005446	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00330	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	"[{""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00330"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00330 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_location-36703d5e93fc_10701add92d3	SGD:S000004688	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07246	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:1101965); ECO:0000269 (PubMed:2188098); ECO:0000269 (PubMed:2943982)	"[{""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_location-b5d74d4cb0f4_1a19d1d67092	SGD:S000004688	RO:0001025	GO:0005743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07246	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	"[{""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 annotates location Mitochondrion inner membrane (SL-0168)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_location-ff27508b3837_4222a111594d	SGD:S000000050	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q01574	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:Q01574"", ""source_assertion"": ""UniProtKB:Q01574 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2393/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q01574"", ""source_assertion"": ""UniProtKB:Q01574 has the exact SGD cross-reference SGD:S000000050."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2393/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q01574"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q01574 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_location-9ed766a3234c_7aa4115a25b9	SGD:S000000050	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q01574	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:Q01574"", ""source_assertion"": ""UniProtKB:Q01574 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2393/comments/1/subcellularLocations/2; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q01574"", ""source_assertion"": ""UniProtKB:Q01574 has the exact SGD cross-reference SGD:S000000050."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2393/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q01574"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q01574 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_location-e954824b2d2d_8d7711d290b5	SGD:S000000050	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q01574	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:Q01574"", ""source_assertion"": ""UniProtKB:Q01574 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2393/comments/1/subcellularLocations/3; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q01574"", ""source_assertion"": ""UniProtKB:Q01574 has the exact SGD cross-reference SGD:S000000050."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2393/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q01574"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q01574 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_cofactor-ea44646ed080_84d6d8d01f4b	SGD:S000004918	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00331	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	"[{""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/comments/0/cofactors/0; /results/23/comments/0/note""}, {""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00331"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00331 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_cofactor-d020d7cd99ba_4e73ce93a31a	SGD:S000005446	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00330	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849)	"[{""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/comments/0/cofactors/0; /results/22/comments/0/note""}, {""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00330"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00330 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4300_cofactor-738cd0b35ac6_80217f628d30	SGD:S000004688	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07246	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	"[{""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/comments/0/cofactors/0; /results/161/comments/0/note""}, {""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P07246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:KEGG_M00373_emc-001_52c01aa90639	RHEA:21037	BFO:0000050	KEGG:M00373	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00373|RHEA:21037	All 14 issued module reactions are retained; K00626 is the module orthology requirement.	"[{""reference_id"": ""KEGG:M00373"", ""source_assertion"": ""M00373 REACTION row R00238 is included in the ethylmalonyl pathway; the complete DEFINITION has 12 required groups and 13 KOs, with K01965+K01966 an obligatory pair."", ""source_locator"": ""ENTRY M00373 / REACTION R00238; ORTHOLOGY K00626; DEFINITION""}, {""reference_id"": ""RHEA:21037"", ""source_assertion"": ""Approved directional equation: 2 acetyl-CoA => acetoacetyl-CoA + CoA"", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/21037; rh:equation; rh:status""}]"	"[{""id"": ""KEGG:M00373"", ""source_sha256"": ""7a191e66d0acdfa35d76713ff136f4240f8626a1d8369207882d3dc7a3965e44"", ""source_version"": ""Complete module flatfile retrieved 2026-10-11; no release number supplied"", ""title"": ""Ethylmalonyl pathway"", ""url"": ""https://rest.kegg.jp/get/M00373""}, {""id"": ""RHEA:21037"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""2 acetyl-CoA => acetoacetyl-CoA + CoA"", ""url"": ""https://www.rhea-db.org/rhea/21037""}]"	""
pathwaymech:KEGG_M00373_emc-002_e145e75270c3	CHEBI:57288	pathwaymech:consumes	RHEA:21037	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21037	Stoichiometric coefficient 2.	"[{""reference_id"": ""RHEA:21037"", ""source_assertion"": ""The approved reaction consumes 2 acetyl-CoA; this is the whole participant identified as CHEBI:57288."", ""source_locator"": ""RDF 21037 rh:substrates http://rdf.rhea-db.org/21036_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_4271; rh:contains2""}]"	"[{""id"": ""RHEA:21037"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""2 acetyl-CoA => acetoacetyl-CoA + CoA"", ""url"": ""https://www.rhea-db.org/rhea/21037""}]"	""
pathwaymech:KEGG_M00373_emc-003_2944a6b3125c	RHEA:21037	pathwaymech:produces	CHEBI:57286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21037	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:21037"", ""source_assertion"": ""The approved reaction produces 1 acetoacetyl-CoA; this is the whole participant identified as CHEBI:57286."", ""source_locator"": ""RDF 21037 rh:products http://rdf.rhea-db.org/21036_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_4872; rh:contains1""}]"	"[{""id"": ""RHEA:21037"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""2 acetyl-CoA => acetoacetyl-CoA + CoA"", ""url"": ""https://www.rhea-db.org/rhea/21037""}]"	""
pathwaymech:KEGG_M00373_emc-004_7ccde7c89149	RHEA:21037	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21037	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:21037"", ""source_assertion"": ""The approved reaction produces 1 CoA; this is the whole participant identified as CHEBI:57287."", ""source_locator"": ""RDF 21037 rh:products http://rdf.rhea-db.org/21036_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_1264; rh:contains1""}]"	"[{""id"": ""RHEA:21037"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""2 acetyl-CoA => acetoacetyl-CoA + CoA"", ""url"": ""https://www.rhea-db.org/rhea/21037""}]"	""
pathwaymech:KEGG_M00373_emc-005_c7d7df3a9c9b	RHEA:45798	BFO:0000050	KEGG:M00373	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00373|RHEA:45798	All 14 issued module reactions are retained; K00023 is the module orthology requirement.	"[{""reference_id"": ""KEGG:M00373"", ""source_assertion"": ""M00373 REACTION row R01977 is included in the ethylmalonyl pathway; the complete DEFINITION has 12 required groups and 13 KOs, with K01965+K01966 an obligatory pair."", ""source_locator"": ""ENTRY M00373 / REACTION R01977; ORTHOLOGY K00023; DEFINITION""}, {""reference_id"": ""RHEA:45798"", ""source_assertion"": ""Approved directional equation: acetoacetyl-CoA + NADPH + H(+) => (3R)-3-hydroxybutanoyl-CoA + NADP(+)"", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/45798; rh:equation; rh:status""}]"	"[{""id"": ""KEGG:M00373"", ""source_sha256"": ""7a191e66d0acdfa35d76713ff136f4240f8626a1d8369207882d3dc7a3965e44"", ""source_version"": ""Complete module flatfile retrieved 2026-10-11; no release number supplied"", ""title"": ""Ethylmalonyl pathway"", ""url"": ""https://rest.kegg.jp/get/M00373""}, {""id"": ""RHEA:45798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""acetoacetyl-CoA + NADPH + H(+) => (3R)-3-hydroxybutanoyl-CoA + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/45798""}]"	""
pathwaymech:KEGG_M00373_emc-006_3c04117945c3	CHEBI:57286	pathwaymech:consumes	RHEA:45798	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45798	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:45798"", ""source_assertion"": ""The approved reaction consumes 1 acetoacetyl-CoA; this is the whole participant identified as CHEBI:57286."", ""source_locator"": ""RDF 45798 rh:substrates http://rdf.rhea-db.org/45796_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_4872; rh:contains1""}]"	"[{""id"": ""RHEA:45798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""acetoacetyl-CoA + NADPH + H(+) => (3R)-3-hydroxybutanoyl-CoA + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/45798""}]"	""
pathwaymech:KEGG_M00373_emc-007_ecec335cc827	CHEBI:57783	pathwaymech:consumes	RHEA:45798	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45798	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:45798"", ""source_assertion"": ""The approved reaction consumes 1 NADPH; this is the whole participant identified as CHEBI:57783."", ""source_locator"": ""RDF 45798 rh:substrates http://rdf.rhea-db.org/45796_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_3438; rh:contains1""}]"	"[{""id"": ""RHEA:45798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""acetoacetyl-CoA + NADPH + H(+) => (3R)-3-hydroxybutanoyl-CoA + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/45798""}]"	""
pathwaymech:KEGG_M00373_emc-008_07d7ee01a509	CHEBI:15378	pathwaymech:consumes	RHEA:45798	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45798	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:45798"", ""source_assertion"": ""The approved reaction consumes 1 H(+); this is the whole participant identified as CHEBI:15378."", ""source_locator"": ""RDF 45798 rh:substrates http://rdf.rhea-db.org/45796_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_3249; rh:contains1""}]"	"[{""id"": ""RHEA:45798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""acetoacetyl-CoA + NADPH + H(+) => (3R)-3-hydroxybutanoyl-CoA + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/45798""}]"	""
pathwaymech:KEGG_M00373_emc-009_2483d0f03b3c	RHEA:45798	pathwaymech:produces	CHEBI:57315	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45798	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:45798"", ""source_assertion"": ""The approved reaction produces 1 (3R)-3-hydroxybutanoyl-CoA; this is the whole participant identified as CHEBI:57315."", ""source_locator"": ""RDF 45798 rh:products http://rdf.rhea-db.org/45796_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_4693; rh:contains1""}]"	"[{""id"": ""RHEA:45798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""acetoacetyl-CoA + NADPH + H(+) => (3R)-3-hydroxybutanoyl-CoA + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/45798""}]"	""
pathwaymech:KEGG_M00373_emc-010_30a3eea683d4	RHEA:45798	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45798	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:45798"", ""source_assertion"": ""The approved reaction produces 1 NADP(+); this is the whole participant identified as CHEBI:58349."", ""source_locator"": ""RDF 45798 rh:products http://rdf.rhea-db.org/45796_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_5188; rh:contains1""}]"	"[{""id"": ""RHEA:45798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""acetoacetyl-CoA + NADPH + H(+) => (3R)-3-hydroxybutanoyl-CoA + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/45798""}]"	""
pathwaymech:KEGG_M00373_emc-011_ab5267b6186b	RHEA:17850	BFO:0000050	KEGG:M00373	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00373|RHEA:17850	All 14 issued module reactions are retained; K17865 is the module orthology requirement.	"[{""reference_id"": ""KEGG:M00373"", ""source_assertion"": ""M00373 REACTION row R03027 is included in the ethylmalonyl pathway; the complete DEFINITION has 12 required groups and 13 KOs, with K01965+K01966 an obligatory pair."", ""source_locator"": ""ENTRY M00373 / REACTION R03027; ORTHOLOGY K17865; DEFINITION""}, {""reference_id"": ""RHEA:17850"", ""source_assertion"": ""Approved directional equation: (3R)-3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/17850; rh:equation; rh:status""}]"	"[{""id"": ""KEGG:M00373"", ""source_sha256"": ""7a191e66d0acdfa35d76713ff136f4240f8626a1d8369207882d3dc7a3965e44"", ""source_version"": ""Complete module flatfile retrieved 2026-10-11; no release number supplied"", ""title"": ""Ethylmalonyl pathway"", ""url"": ""https://rest.kegg.jp/get/M00373""}, {""id"": ""RHEA:17850"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(3R)-3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"", ""url"": ""https://www.rhea-db.org/rhea/17850""}]"	""
pathwaymech:KEGG_M00373_emc-012_86b47ef21755	CHEBI:57315	pathwaymech:consumes	RHEA:17850	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17850	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:17850"", ""source_assertion"": ""The approved reaction consumes 1 (3R)-3-hydroxybutanoyl-CoA; this is the whole participant identified as CHEBI:57315."", ""source_locator"": ""RDF 17850 rh:substrates http://rdf.rhea-db.org/17849_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_4693; rh:contains1""}]"	"[{""id"": ""RHEA:17850"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(3R)-3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"", ""url"": ""https://www.rhea-db.org/rhea/17850""}]"	""
pathwaymech:KEGG_M00373_emc-013_2879856874a6	RHEA:17850	pathwaymech:produces	CHEBI:57332	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17850	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:17850"", ""source_assertion"": ""The approved reaction produces 1 (2E)-butenoyl-CoA; this is the whole participant identified as CHEBI:57332."", ""source_locator"": ""RDF 17850 rh:products http://rdf.rhea-db.org/17849_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_2633; rh:contains1""}]"	"[{""id"": ""RHEA:17850"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(3R)-3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"", ""url"": ""https://www.rhea-db.org/rhea/17850""}]"	""
pathwaymech:KEGG_M00373_emc-014_ad9a2f9fd299	RHEA:17850	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17850	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:17850"", ""source_assertion"": ""The approved reaction produces 1 H2O; this is the whole participant identified as CHEBI:15377."", ""source_locator"": ""RDF 17850 rh:products http://rdf.rhea-db.org/17849_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_1283; rh:contains1""}]"	"[{""id"": ""RHEA:17850"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(3R)-3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"", ""url"": ""https://www.rhea-db.org/rhea/17850""}]"	""
pathwaymech:KEGG_M00373_emc-015_5ea46db9c6f5	RHEA:28084	BFO:0000050	KEGG:M00373	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00373|RHEA:28084	All 14 issued module reactions are retained; K14446 is the module orthology requirement.	"[{""reference_id"": ""KEGG:M00373"", ""source_assertion"": ""M00373 REACTION row R09291 is included in the ethylmalonyl pathway; the complete DEFINITION has 12 required groups and 13 KOs, with K01965+K01966 an obligatory pair."", ""source_locator"": ""ENTRY M00373 / REACTION R09291; ORTHOLOGY K14446; DEFINITION""}, {""reference_id"": ""RHEA:28084"", ""source_assertion"": ""Approved directional equation: (2E)-butenoyl-CoA + CO2 + NADPH => (2S)-ethylmalonyl-CoA + NADP(+)"", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/28084; rh:equation; rh:status""}]"	"[{""id"": ""KEGG:M00373"", ""source_sha256"": ""7a191e66d0acdfa35d76713ff136f4240f8626a1d8369207882d3dc7a3965e44"", ""source_version"": ""Complete module flatfile retrieved 2026-10-11; no release number supplied"", ""title"": ""Ethylmalonyl pathway"", ""url"": ""https://rest.kegg.jp/get/M00373""}, {""id"": ""RHEA:28084"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2E)-butenoyl-CoA + CO2 + NADPH => (2S)-ethylmalonyl-CoA + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/28084""}]"	""
pathwaymech:KEGG_M00373_emc-016_171dfafd2ecb	CHEBI:57332	pathwaymech:consumes	RHEA:28084	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28084	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:28084"", ""source_assertion"": ""The approved reaction consumes 1 (2E)-butenoyl-CoA; this is the whole participant identified as CHEBI:57332."", ""source_locator"": ""RDF 28084 rh:substrates http://rdf.rhea-db.org/28082_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_2633; rh:contains1""}]"	"[{""id"": ""RHEA:28084"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2E)-butenoyl-CoA + CO2 + NADPH => (2S)-ethylmalonyl-CoA + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/28084""}]"	""
pathwaymech:KEGG_M00373_emc-017_5822636beab1	CHEBI:16526	pathwaymech:consumes	RHEA:28084	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28084	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:28084"", ""source_assertion"": ""The approved reaction consumes 1 CO2; this is the whole participant identified as CHEBI:16526."", ""source_locator"": ""RDF 28084 rh:substrates http://rdf.rhea-db.org/28082_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_4391; rh:contains1""}]"	"[{""id"": ""RHEA:28084"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2E)-butenoyl-CoA + CO2 + NADPH => (2S)-ethylmalonyl-CoA + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/28084""}]"	""
pathwaymech:KEGG_M00373_emc-018_dcca83ddd7e7	CHEBI:57783	pathwaymech:consumes	RHEA:28084	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28084	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:28084"", ""source_assertion"": ""The approved reaction consumes 1 NADPH; this is the whole participant identified as CHEBI:57783."", ""source_locator"": ""RDF 28084 rh:substrates http://rdf.rhea-db.org/28082_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_3438; rh:contains1""}]"	"[{""id"": ""RHEA:28084"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2E)-butenoyl-CoA + CO2 + NADPH => (2S)-ethylmalonyl-CoA + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/28084""}]"	""
pathwaymech:KEGG_M00373_emc-019_df37ceefe16a	RHEA:28084	pathwaymech:produces	CHEBI:60909	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28084	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:28084"", ""source_assertion"": ""The approved reaction produces 1 (2S)-ethylmalonyl-CoA; this is the whole participant identified as CHEBI:60909."", ""source_locator"": ""RDF 28084 rh:products http://rdf.rhea-db.org/28082_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_6333; rh:contains1""}]"	"[{""id"": ""RHEA:28084"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2E)-butenoyl-CoA + CO2 + NADPH => (2S)-ethylmalonyl-CoA + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/28084""}]"	""
pathwaymech:KEGG_M00373_emc-020_4cb97bd2838a	RHEA:28084	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28084	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:28084"", ""source_assertion"": ""The approved reaction produces 1 NADP(+); this is the whole participant identified as CHEBI:58349."", ""source_locator"": ""RDF 28084 rh:products http://rdf.rhea-db.org/28082_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_5188; rh:contains1""}]"	"[{""id"": ""RHEA:28084"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2E)-butenoyl-CoA + CO2 + NADPH => (2S)-ethylmalonyl-CoA + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/28084""}]"	""
pathwaymech:KEGG_M00373_emc-021_c7077e7c50f3	RHEA:59730	BFO:0000050	KEGG:M00373	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00373|RHEA:59730	All 14 issued module reactions are retained; K05606 is the module orthology requirement.	"[{""reference_id"": ""KEGG:M00373"", ""source_assertion"": ""M00373 REACTION row R09979 is included in the ethylmalonyl pathway; the complete DEFINITION has 12 required groups and 13 KOs, with K01965+K01966 an obligatory pair."", ""source_locator"": ""ENTRY M00373 / REACTION R09979; ORTHOLOGY K05606; DEFINITION""}, {""reference_id"": ""RHEA:59730"", ""source_assertion"": ""Approved directional equation: (2S)-ethylmalonyl-CoA => (2R)-ethylmalonyl-CoA"", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/59730; rh:equation; rh:status""}]"	"[{""id"": ""KEGG:M00373"", ""source_sha256"": ""7a191e66d0acdfa35d76713ff136f4240f8626a1d8369207882d3dc7a3965e44"", ""source_version"": ""Complete module flatfile retrieved 2026-10-11; no release number supplied"", ""title"": ""Ethylmalonyl pathway"", ""url"": ""https://rest.kegg.jp/get/M00373""}, {""id"": ""RHEA:59730"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2S)-ethylmalonyl-CoA => (2R)-ethylmalonyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/59730""}]"	""
pathwaymech:KEGG_M00373_emc-022_8ffbcdd3ff84	CHEBI:60909	pathwaymech:consumes	RHEA:59730	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59730	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:59730"", ""source_assertion"": ""The approved reaction consumes 1 (2S)-ethylmalonyl-CoA; this is the whole participant identified as CHEBI:60909."", ""source_locator"": ""RDF 59730 rh:substrates http://rdf.rhea-db.org/59728_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_6333; rh:contains1""}]"	"[{""id"": ""RHEA:59730"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2S)-ethylmalonyl-CoA => (2R)-ethylmalonyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/59730""}]"	""
pathwaymech:KEGG_M00373_emc-023_e67b10e504d9	RHEA:59730	pathwaymech:produces	CHEBI:85316	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59730	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:59730"", ""source_assertion"": ""The approved reaction produces 1 (2R)-ethylmalonyl-CoA; this is the whole participant identified as CHEBI:85316."", ""source_locator"": ""RDF 59730 rh:products http://rdf.rhea-db.org/59728_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_11275; rh:contains1""}]"	"[{""id"": ""RHEA:59730"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2S)-ethylmalonyl-CoA => (2R)-ethylmalonyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/59730""}]"	""
pathwaymech:KEGG_M00373_emc-024_ff128d3369c3	RHEA:45577	BFO:0000050	KEGG:M00373	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00373|RHEA:45577	All 14 issued module reactions are retained; K14447 is the module orthology requirement.	"[{""reference_id"": ""KEGG:M00373"", ""source_assertion"": ""M00373 REACTION row R09292 is included in the ethylmalonyl pathway; the complete DEFINITION has 12 required groups and 13 KOs, with K01965+K01966 an obligatory pair."", ""source_locator"": ""ENTRY M00373 / REACTION R09292; ORTHOLOGY K14447; DEFINITION""}, {""reference_id"": ""RHEA:45577"", ""source_assertion"": ""Approved directional equation: (2R)-ethylmalonyl-CoA => (2S)-methylsuccinyl-CoA"", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/45577; rh:equation; rh:status""}]"	"[{""id"": ""KEGG:M00373"", ""source_sha256"": ""7a191e66d0acdfa35d76713ff136f4240f8626a1d8369207882d3dc7a3965e44"", ""source_version"": ""Complete module flatfile retrieved 2026-10-11; no release number supplied"", ""title"": ""Ethylmalonyl pathway"", ""url"": ""https://rest.kegg.jp/get/M00373""}, {""id"": ""RHEA:45577"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2R)-ethylmalonyl-CoA => (2S)-methylsuccinyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/45577""}]"	""
pathwaymech:KEGG_M00373_emc-025_d258f8e5ec8e	CHEBI:85316	pathwaymech:consumes	RHEA:45577	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45577	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:45577"", ""source_assertion"": ""The approved reaction consumes 1 (2R)-ethylmalonyl-CoA; this is the whole participant identified as CHEBI:85316."", ""source_locator"": ""RDF 45577 rh:substrates http://rdf.rhea-db.org/45576_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_11275; rh:contains1""}]"	"[{""id"": ""RHEA:45577"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2R)-ethylmalonyl-CoA => (2S)-methylsuccinyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/45577""}]"	""
pathwaymech:KEGG_M00373_emc-026_a28b8411522d	RHEA:45577	pathwaymech:produces	CHEBI:84866	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45577	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:45577"", ""source_assertion"": ""The approved reaction produces 1 (2S)-methylsuccinyl-CoA; this is the whole participant identified as CHEBI:84866."", ""source_locator"": ""RDF 45577 rh:products http://rdf.rhea-db.org/45576_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_11065; rh:contains1""}]"	"[{""id"": ""RHEA:45577"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2R)-ethylmalonyl-CoA => (2S)-methylsuccinyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/45577""}]"	""
pathwaymech:KEGG_M00373_emc-027_30960a2f918d	RHEA:45029	BFO:0000050	KEGG:M00373	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00373|RHEA:45029	All 14 issued module reactions are retained; K14448 is the module orthology requirement.	"[{""reference_id"": ""KEGG:M00373"", ""source_assertion"": ""M00373 REACTION row R09293 is included in the ethylmalonyl pathway; the complete DEFINITION has 12 required groups and 13 KOs, with K01965+K01966 an obligatory pair."", ""source_locator"": ""ENTRY M00373 / REACTION R09293; ORTHOLOGY K14448; DEFINITION""}, {""reference_id"": ""RHEA:45029"", ""source_assertion"": ""Approved directional equation: (2S)-methylsuccinyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) => 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]"", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/45029; rh:equation; rh:status""}]"	"[{""id"": ""KEGG:M00373"", ""source_sha256"": ""7a191e66d0acdfa35d76713ff136f4240f8626a1d8369207882d3dc7a3965e44"", ""source_version"": ""Complete module flatfile retrieved 2026-10-11; no release number supplied"", ""title"": ""Ethylmalonyl pathway"", ""url"": ""https://rest.kegg.jp/get/M00373""}, {""id"": ""RHEA:45029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2S)-methylsuccinyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) => 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]"", ""url"": ""https://www.rhea-db.org/rhea/45029""}]"	""
pathwaymech:KEGG_M00373_emc-028_5255155db3a9	CHEBI:84866	pathwaymech:consumes	RHEA:45029	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45029	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:45029"", ""source_assertion"": ""The approved reaction consumes 1 (2S)-methylsuccinyl-CoA; this is the whole participant identified as CHEBI:84866."", ""source_locator"": ""RDF 45029 rh:substrates http://rdf.rhea-db.org/45028_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_11065; rh:contains1""}]"	"[{""id"": ""RHEA:45029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2S)-methylsuccinyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) => 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]"", ""url"": ""https://www.rhea-db.org/rhea/45029""}]"	""
pathwaymech:KEGG_M00373_emc-029_a63999c1e88e	RHEA-COMP:10685	pathwaymech:consumes	RHEA:45029	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45029	Stoichiometric coefficient 1. Whole ETF protein redox state in the formal Rhea equation. The ACAD-family two-ETF mechanism is consistent with Mcd ETF semiquinone formation; these Mcd assays do not directly measure two-ETF microscopic stoichiometry. See emc-084 for primary scope.	"[{""reference_id"": ""RHEA:45029"", ""source_assertion"": ""The approved reaction consumes 1 oxidized [electron-transfer flavoprotein]; this is the whole participant identified as RHEA-COMP:10685."", ""source_locator"": ""RDF 45029 rh:substrates http://rdf.rhea-db.org/45028_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_10685; rh:contains1""}]"	"[{""id"": ""RHEA:45029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2S)-methylsuccinyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) => 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]"", ""url"": ""https://www.rhea-db.org/rhea/45029""}]"	""
pathwaymech:KEGG_M00373_emc-030_9d56f0723196	CHEBI:15378	pathwaymech:consumes	RHEA:45029	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45029	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:45029"", ""source_assertion"": ""The approved reaction consumes 1 H(+); this is the whole participant identified as CHEBI:15378."", ""source_locator"": ""RDF 45029 rh:substrates http://rdf.rhea-db.org/45028_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_3249; rh:contains1""}]"	"[{""id"": ""RHEA:45029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2S)-methylsuccinyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) => 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]"", ""url"": ""https://www.rhea-db.org/rhea/45029""}]"	""
pathwaymech:KEGG_M00373_emc-031_310a99c57561	RHEA:45029	pathwaymech:produces	CHEBI:75635	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45029	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:45029"", ""source_assertion"": ""The approved reaction produces 1 2-methylfumaryl-CoA; this is the whole participant identified as CHEBI:75635."", ""source_locator"": ""RDF 45029 rh:products http://rdf.rhea-db.org/45028_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_8546; rh:contains1""}]"	"[{""id"": ""RHEA:45029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2S)-methylsuccinyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) => 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]"", ""url"": ""https://www.rhea-db.org/rhea/45029""}]"	""
pathwaymech:KEGG_M00373_emc-032_81fffd64bbf1	RHEA:45029	pathwaymech:produces	RHEA-COMP:10686	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45029	Stoichiometric coefficient 1. Whole ETF protein redox state in the formal Rhea equation. The ACAD-family two-ETF mechanism is consistent with Mcd ETF semiquinone formation; these Mcd assays do not directly measure two-ETF microscopic stoichiometry. See emc-084 for primary scope.	"[{""reference_id"": ""RHEA:45029"", ""source_assertion"": ""The approved reaction produces 1 reduced [electron-transfer flavoprotein]; this is the whole participant identified as RHEA-COMP:10686."", ""source_locator"": ""RDF 45029 rh:products http://rdf.rhea-db.org/45028_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_10686; rh:contains1""}]"	"[{""id"": ""RHEA:45029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2S)-methylsuccinyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) => 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]"", ""url"": ""https://www.rhea-db.org/rhea/45029""}]"	""
pathwaymech:KEGG_M00373_emc-033_4b00dddf9cec	RHEA:38265	BFO:0000050	KEGG:M00373	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00373|RHEA:38265	All 14 issued module reactions are retained; K14449 is the module orthology requirement.	"[{""reference_id"": ""KEGG:M00373"", ""source_assertion"": ""M00373 REACTION row R05076 is included in the ethylmalonyl pathway; the complete DEFINITION has 12 required groups and 13 KOs, with K01965+K01966 an obligatory pair."", ""source_locator"": ""ENTRY M00373 / REACTION R05076; ORTHOLOGY K14449; DEFINITION""}, {""reference_id"": ""RHEA:38265"", ""source_assertion"": ""Approved directional equation: 2-methylfumaryl-CoA + H2O => (2R,3S)-beta-methylmalyl-CoA"", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/38265; rh:equation; rh:status""}]"	"[{""id"": ""KEGG:M00373"", ""source_sha256"": ""7a191e66d0acdfa35d76713ff136f4240f8626a1d8369207882d3dc7a3965e44"", ""source_version"": ""Complete module flatfile retrieved 2026-10-11; no release number supplied"", ""title"": ""Ethylmalonyl pathway"", ""url"": ""https://rest.kegg.jp/get/M00373""}, {""id"": ""RHEA:38265"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""2-methylfumaryl-CoA + H2O => (2R,3S)-beta-methylmalyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/38265""}]"	""
pathwaymech:KEGG_M00373_emc-034_e294c8e03873	CHEBI:75635	pathwaymech:consumes	RHEA:38265	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38265	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38265"", ""source_assertion"": ""The approved reaction consumes 1 2-methylfumaryl-CoA; this is the whole participant identified as CHEBI:75635."", ""source_locator"": ""RDF 38265 rh:substrates http://rdf.rhea-db.org/38263_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_8546; rh:contains1""}]"	"[{""id"": ""RHEA:38265"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""2-methylfumaryl-CoA + H2O => (2R,3S)-beta-methylmalyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/38265""}]"	""
pathwaymech:KEGG_M00373_emc-035_ff562953e576	CHEBI:15377	pathwaymech:consumes	RHEA:38265	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38265	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38265"", ""source_assertion"": ""The approved reaction consumes 1 H2O; this is the whole participant identified as CHEBI:15377."", ""source_locator"": ""RDF 38265 rh:substrates http://rdf.rhea-db.org/38263_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_1283; rh:contains1""}]"	"[{""id"": ""RHEA:38265"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""2-methylfumaryl-CoA + H2O => (2R,3S)-beta-methylmalyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/38265""}]"	""
pathwaymech:KEGG_M00373_emc-036_998c3ec1e152	RHEA:38265	pathwaymech:produces	CHEBI:75634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38265	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38265"", ""source_assertion"": ""The approved reaction produces 1 (2R,3S)-beta-methylmalyl-CoA; this is the whole participant identified as CHEBI:75634."", ""source_locator"": ""RDF 38265 rh:products http://rdf.rhea-db.org/38263_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_8545; rh:contains1""}]"	"[{""id"": ""RHEA:38265"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""2-methylfumaryl-CoA + H2O => (2R,3S)-beta-methylmalyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/38265""}]"	""
pathwaymech:KEGG_M00373_emc-037_5ed922bc52d2	RHEA:38260	BFO:0000050	KEGG:M00373	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00373|RHEA:38260	All 14 issued module reactions are retained; K08691 is the module orthology requirement.	"[{""reference_id"": ""KEGG:M00373"", ""source_assertion"": ""M00373 REACTION row R00934 is included in the ethylmalonyl pathway; the complete DEFINITION has 12 required groups and 13 KOs, with K01965+K01966 an obligatory pair."", ""source_locator"": ""ENTRY M00373 / REACTION R00934; ORTHOLOGY K08691; DEFINITION""}, {""reference_id"": ""RHEA:38260"", ""source_assertion"": ""Approved directional equation: (2R,3S)-beta-methylmalyl-CoA => propanoyl-CoA + glyoxylate"", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/38260; rh:equation; rh:status""}]"	"[{""id"": ""KEGG:M00373"", ""source_sha256"": ""7a191e66d0acdfa35d76713ff136f4240f8626a1d8369207882d3dc7a3965e44"", ""source_version"": ""Complete module flatfile retrieved 2026-10-11; no release number supplied"", ""title"": ""Ethylmalonyl pathway"", ""url"": ""https://rest.kegg.jp/get/M00373""}, {""id"": ""RHEA:38260"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2R,3S)-beta-methylmalyl-CoA => propanoyl-CoA + glyoxylate"", ""url"": ""https://www.rhea-db.org/rhea/38260""}]"	""
pathwaymech:KEGG_M00373_emc-038_179b4d525827	CHEBI:75634	pathwaymech:consumes	RHEA:38260	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38260	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38260"", ""source_assertion"": ""The approved reaction consumes 1 (2R,3S)-beta-methylmalyl-CoA; this is the whole participant identified as CHEBI:75634."", ""source_locator"": ""RDF 38260 rh:substrates http://rdf.rhea-db.org/38259_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_8545; rh:contains1""}]"	"[{""id"": ""RHEA:38260"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2R,3S)-beta-methylmalyl-CoA => propanoyl-CoA + glyoxylate"", ""url"": ""https://www.rhea-db.org/rhea/38260""}]"	""
pathwaymech:KEGG_M00373_emc-039_bf254e4d7613	RHEA:38260	pathwaymech:produces	CHEBI:57392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38260	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38260"", ""source_assertion"": ""The approved reaction produces 1 propanoyl-CoA; this is the whole participant identified as CHEBI:57392."", ""source_locator"": ""RDF 38260 rh:products http://rdf.rhea-db.org/38259_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_3421; rh:contains1""}]"	"[{""id"": ""RHEA:38260"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2R,3S)-beta-methylmalyl-CoA => propanoyl-CoA + glyoxylate"", ""url"": ""https://www.rhea-db.org/rhea/38260""}]"	""
pathwaymech:KEGG_M00373_emc-040_325becbb86df	RHEA:38260	pathwaymech:produces	CHEBI:36655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38260	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38260"", ""source_assertion"": ""The approved reaction produces 1 glyoxylate; this is the whole participant identified as CHEBI:36655."", ""source_locator"": ""RDF 38260 rh:products http://rdf.rhea-db.org/38259_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_3124; rh:contains1""}]"	"[{""id"": ""RHEA:38260"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2R,3S)-beta-methylmalyl-CoA => propanoyl-CoA + glyoxylate"", ""url"": ""https://www.rhea-db.org/rhea/38260""}]"	""
pathwaymech:KEGG_M00373_emc-041_a2fe59b8f6b1	RHEA:16631	BFO:0000050	KEGG:M00373	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00373|RHEA:16631	All 14 issued module reactions are retained; K08691 is the module orthology requirement.	"[{""reference_id"": ""KEGG:M00373"", ""source_assertion"": ""M00373 REACTION row R00473 is included in the ethylmalonyl pathway; the complete DEFINITION has 12 required groups and 13 KOs, with K01965+K01966 an obligatory pair."", ""source_locator"": ""ENTRY M00373 / REACTION R00473; ORTHOLOGY K08691; DEFINITION""}, {""reference_id"": ""RHEA:16631"", ""source_assertion"": ""Approved directional equation: glyoxylate + acetyl-CoA => (S)-malyl-CoA"", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/16631; rh:equation; rh:status""}]"	"[{""id"": ""KEGG:M00373"", ""source_sha256"": ""7a191e66d0acdfa35d76713ff136f4240f8626a1d8369207882d3dc7a3965e44"", ""source_version"": ""Complete module flatfile retrieved 2026-10-11; no release number supplied"", ""title"": ""Ethylmalonyl pathway"", ""url"": ""https://rest.kegg.jp/get/M00373""}, {""id"": ""RHEA:16631"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""glyoxylate + acetyl-CoA => (S)-malyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/16631""}]"	""
pathwaymech:KEGG_M00373_emc-042_f952792bc55a	CHEBI:36655	pathwaymech:consumes	RHEA:16631	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16631	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:16631"", ""source_assertion"": ""The approved reaction consumes 1 glyoxylate; this is the whole participant identified as CHEBI:36655."", ""source_locator"": ""RDF 16631 rh:substrates http://rdf.rhea-db.org/16629_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_3124; rh:contains1""}]"	"[{""id"": ""RHEA:16631"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""glyoxylate + acetyl-CoA => (S)-malyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/16631""}]"	""
pathwaymech:KEGG_M00373_emc-043_939fe01b27b8	CHEBI:57288	pathwaymech:consumes	RHEA:16631	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16631	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:16631"", ""source_assertion"": ""The approved reaction consumes 1 acetyl-CoA; this is the whole participant identified as CHEBI:57288."", ""source_locator"": ""RDF 16631 rh:substrates http://rdf.rhea-db.org/16629_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_4271; rh:contains1""}]"	"[{""id"": ""RHEA:16631"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""glyoxylate + acetyl-CoA => (S)-malyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/16631""}]"	""
pathwaymech:KEGG_M00373_emc-044_b270dfce53f2	RHEA:16631	pathwaymech:produces	CHEBI:57317	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16631	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:16631"", ""source_assertion"": ""The approved reaction produces 1 (S)-malyl-CoA; this is the whole participant identified as CHEBI:57317."", ""source_locator"": ""RDF 16631 rh:products http://rdf.rhea-db.org/16629_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_3610; rh:contains1""}]"	"[{""id"": ""RHEA:16631"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""glyoxylate + acetyl-CoA => (S)-malyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/16631""}]"	""
pathwaymech:KEGG_M00373_emc-045_9b7279afe0d1	RHEA:38292	BFO:0000050	KEGG:M00373	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00373|RHEA:38292	All 14 issued module reactions are retained; K14451 is the module orthology requirement.	"[{""reference_id"": ""KEGG:M00373"", ""source_assertion"": ""M00373 REACTION row R10612 is included in the ethylmalonyl pathway; the complete DEFINITION has 12 required groups and 13 KOs, with K01965+K01966 an obligatory pair."", ""source_locator"": ""ENTRY M00373 / REACTION R10612; ORTHOLOGY K14451; DEFINITION""}, {""reference_id"": ""RHEA:38292"", ""source_assertion"": ""Approved directional equation: (S)-malyl-CoA + H2O => (S)-malate + CoA + H(+)"", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/38292; rh:equation; rh:status""}]"	"[{""id"": ""KEGG:M00373"", ""source_sha256"": ""7a191e66d0acdfa35d76713ff136f4240f8626a1d8369207882d3dc7a3965e44"", ""source_version"": ""Complete module flatfile retrieved 2026-10-11; no release number supplied"", ""title"": ""Ethylmalonyl pathway"", ""url"": ""https://rest.kegg.jp/get/M00373""}, {""id"": ""RHEA:38292"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(S)-malyl-CoA + H2O => (S)-malate + CoA + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/38292""}]"	""
pathwaymech:KEGG_M00373_emc-046_819d15dc4cc5	CHEBI:57317	pathwaymech:consumes	RHEA:38292	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38292	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38292"", ""source_assertion"": ""The approved reaction consumes 1 (S)-malyl-CoA; this is the whole participant identified as CHEBI:57317."", ""source_locator"": ""RDF 38292 rh:substrates http://rdf.rhea-db.org/38291_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_3610; rh:contains1""}]"	"[{""id"": ""RHEA:38292"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(S)-malyl-CoA + H2O => (S)-malate + CoA + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/38292""}]"	""
pathwaymech:KEGG_M00373_emc-047_9e86554eccca	CHEBI:15377	pathwaymech:consumes	RHEA:38292	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38292	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38292"", ""source_assertion"": ""The approved reaction consumes 1 H2O; this is the whole participant identified as CHEBI:15377."", ""source_locator"": ""RDF 38292 rh:substrates http://rdf.rhea-db.org/38291_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_1283; rh:contains1""}]"	"[{""id"": ""RHEA:38292"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(S)-malyl-CoA + H2O => (S)-malate + CoA + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/38292""}]"	""
pathwaymech:KEGG_M00373_emc-048_c4ff5c051abc	RHEA:38292	pathwaymech:produces	CHEBI:15589	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38292	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38292"", ""source_assertion"": ""The approved reaction produces 1 (S)-malate; this is the whole participant identified as CHEBI:15589."", ""source_locator"": ""RDF 38292 rh:products http://rdf.rhea-db.org/38291_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_3953; rh:contains1""}]"	"[{""id"": ""RHEA:38292"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(S)-malyl-CoA + H2O => (S)-malate + CoA + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/38292""}]"	""
pathwaymech:KEGG_M00373_emc-049_7263ea54954a	RHEA:38292	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38292	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38292"", ""source_assertion"": ""The approved reaction produces 1 CoA; this is the whole participant identified as CHEBI:57287."", ""source_locator"": ""RDF 38292 rh:products http://rdf.rhea-db.org/38291_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_1264; rh:contains1""}]"	"[{""id"": ""RHEA:38292"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(S)-malyl-CoA + H2O => (S)-malate + CoA + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/38292""}]"	""
pathwaymech:KEGG_M00373_emc-050_a571ddc4cf2f	RHEA:38292	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38292	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38292"", ""source_assertion"": ""The approved reaction produces 1 H(+); this is the whole participant identified as CHEBI:15378."", ""source_locator"": ""RDF 38292 rh:products http://rdf.rhea-db.org/38291_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_3249; rh:contains1""}]"	"[{""id"": ""RHEA:38292"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(S)-malyl-CoA + H2O => (S)-malate + CoA + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/38292""}]"	""
pathwaymech:KEGG_M00373_emc-051_b1ebe7778f20	RHEA:23721	BFO:0000050	KEGG:M00373	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00373|RHEA:23721	All 14 issued module reactions are retained; K01965+K01966 is the module orthology requirement.	"[{""reference_id"": ""KEGG:M00373"", ""source_assertion"": ""M00373 REACTION row R01859 is included in the ethylmalonyl pathway; the complete DEFINITION has 12 required groups and 13 KOs, with K01965+K01966 an obligatory pair."", ""source_locator"": ""ENTRY M00373 / REACTION R01859; ORTHOLOGY K01965+K01966; DEFINITION""}, {""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Approved directional equation: propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/23721; rh:equation; rh:status""}]"	"[{""id"": ""KEGG:M00373"", ""source_sha256"": ""7a191e66d0acdfa35d76713ff136f4240f8626a1d8369207882d3dc7a3965e44"", ""source_version"": ""Complete module flatfile retrieved 2026-10-11; no release number supplied"", ""title"": ""Ethylmalonyl pathway"", ""url"": ""https://rest.kegg.jp/get/M00373""}, {""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23721""}]"	""
pathwaymech:KEGG_M00373_emc-052_e95fcc017322	CHEBI:57392	pathwaymech:consumes	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""The approved reaction consumes 1 propanoyl-CoA; this is the whole participant identified as CHEBI:57392."", ""source_locator"": ""RDF 23721 rh:substrates http://rdf.rhea-db.org/23720_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_3421; rh:contains1""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23721""}]"	""
pathwaymech:KEGG_M00373_emc-053_e72d70be0147	CHEBI:17544	pathwaymech:consumes	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""The approved reaction consumes 1 hydrogencarbonate; this is the whole participant identified as CHEBI:17544."", ""source_locator"": ""RDF 23721 rh:substrates http://rdf.rhea-db.org/23720_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_1123; rh:contains1""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23721""}]"	""
pathwaymech:KEGG_M00373_emc-054_7cb16514ff21	CHEBI:30616	pathwaymech:consumes	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""The approved reaction consumes 1 ATP; this is the whole participant identified as CHEBI:30616."", ""source_locator"": ""RDF 23721 rh:substrates http://rdf.rhea-db.org/23720_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_6372; rh:contains1""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23721""}]"	""
pathwaymech:KEGG_M00373_emc-055_7436d0f98696	RHEA:23721	pathwaymech:produces	CHEBI:57327	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""The approved reaction produces 1 (S)-methylmalonyl-CoA; this is the whole participant identified as CHEBI:57327."", ""source_locator"": ""RDF 23721 rh:products http://rdf.rhea-db.org/23720_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_2780; rh:contains1""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23721""}]"	""
pathwaymech:KEGG_M00373_emc-056_d12b71f4a2ec	RHEA:23721	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""The approved reaction produces 1 ADP; this is the whole participant identified as CHEBI:456216."", ""source_locator"": ""RDF 23721 rh:products http://rdf.rhea-db.org/23720_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_2710; rh:contains1""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23721""}]"	""
pathwaymech:KEGG_M00373_emc-057_fd85c1d0f27e	RHEA:23721	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""The approved reaction produces 1 phosphate; this is the whole participant identified as CHEBI:43474."", ""source_locator"": ""RDF 23721 rh:products http://rdf.rhea-db.org/23720_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_5518; rh:contains1""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23721""}]"	""
pathwaymech:KEGG_M00373_emc-058_30ea3148591b	RHEA:23721	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""The approved reaction produces 1 H(+); this is the whole participant identified as CHEBI:15378."", ""source_locator"": ""RDF 23721 rh:products http://rdf.rhea-db.org/23720_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_3249; rh:contains1""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23721""}]"	""
pathwaymech:KEGG_M00373_emc-059_1277beef4886	RHEA:20555	BFO:0000050	KEGG:M00373	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00373|RHEA:20555	All 14 issued module reactions are retained; K05606 is the module orthology requirement.	"[{""reference_id"": ""KEGG:M00373"", ""source_assertion"": ""M00373 REACTION row R02765 is included in the ethylmalonyl pathway; the complete DEFINITION has 12 required groups and 13 KOs, with K01965+K01966 an obligatory pair."", ""source_locator"": ""ENTRY M00373 / REACTION R02765; ORTHOLOGY K05606; DEFINITION""}, {""reference_id"": ""RHEA:20555"", ""source_assertion"": ""Approved directional equation: (S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA"", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/20555; rh:equation; rh:status""}]"	"[{""id"": ""KEGG:M00373"", ""source_sha256"": ""7a191e66d0acdfa35d76713ff136f4240f8626a1d8369207882d3dc7a3965e44"", ""source_version"": ""Complete module flatfile retrieved 2026-10-11; no release number supplied"", ""title"": ""Ethylmalonyl pathway"", ""url"": ""https://rest.kegg.jp/get/M00373""}, {""id"": ""RHEA:20555"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/20555""}]"	""
pathwaymech:KEGG_M00373_emc-060_96d8a60dfb37	CHEBI:57327	pathwaymech:consumes	RHEA:20555	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20555	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:20555"", ""source_assertion"": ""The approved reaction consumes 1 (S)-methylmalonyl-CoA; this is the whole participant identified as CHEBI:57327."", ""source_locator"": ""RDF 20555 rh:substrates http://rdf.rhea-db.org/20553_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_2780; rh:contains1""}]"	"[{""id"": ""RHEA:20555"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/20555""}]"	""
pathwaymech:KEGG_M00373_emc-061_07d486d6e747	RHEA:20555	pathwaymech:produces	CHEBI:57326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20555	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:20555"", ""source_assertion"": ""The approved reaction produces 1 (R)-methylmalonyl-CoA; this is the whole participant identified as CHEBI:57326."", ""source_locator"": ""RDF 20555 rh:products http://rdf.rhea-db.org/20553_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_1391; rh:contains1""}]"	"[{""id"": ""RHEA:20555"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/20555""}]"	""
pathwaymech:KEGG_M00373_emc-062_abaeb8e26748	RHEA:22889	BFO:0000050	KEGG:M00373	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00373|RHEA:22889	All 14 issued module reactions are retained; K01847 is the module orthology requirement.	"[{""reference_id"": ""KEGG:M00373"", ""source_assertion"": ""M00373 REACTION row R00833 is included in the ethylmalonyl pathway; the complete DEFINITION has 12 required groups and 13 KOs, with K01965+K01966 an obligatory pair."", ""source_locator"": ""ENTRY M00373 / REACTION R00833; ORTHOLOGY K01847; DEFINITION""}, {""reference_id"": ""RHEA:22889"", ""source_assertion"": ""Approved directional equation: (R)-methylmalonyl-CoA => succinyl-CoA"", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/22889; rh:equation; rh:status""}]"	"[{""id"": ""KEGG:M00373"", ""source_sha256"": ""7a191e66d0acdfa35d76713ff136f4240f8626a1d8369207882d3dc7a3965e44"", ""source_version"": ""Complete module flatfile retrieved 2026-10-11; no release number supplied"", ""title"": ""Ethylmalonyl pathway"", ""url"": ""https://rest.kegg.jp/get/M00373""}, {""id"": ""RHEA:22889"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(R)-methylmalonyl-CoA => succinyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/22889""}]"	""
pathwaymech:KEGG_M00373_emc-063_9f3b55a96e1d	CHEBI:57326	pathwaymech:consumes	RHEA:22889	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22889	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:22889"", ""source_assertion"": ""The approved reaction consumes 1 (R)-methylmalonyl-CoA; this is the whole participant identified as CHEBI:57326."", ""source_locator"": ""RDF 22889 rh:substrates http://rdf.rhea-db.org/22888_L; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_1391; rh:contains1""}]"	"[{""id"": ""RHEA:22889"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(R)-methylmalonyl-CoA => succinyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/22889""}]"	""
pathwaymech:KEGG_M00373_emc-064_21e58be11edd	RHEA:22889	pathwaymech:produces	CHEBI:57292	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22889	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:22889"", ""source_assertion"": ""The approved reaction produces 1 succinyl-CoA; this is the whole participant identified as CHEBI:57292."", ""source_locator"": ""RDF 22889 rh:products http://rdf.rhea-db.org/22888_R; rh:contains participant / rh:compound http://rdf.rhea-db.org/Compound_4684; rh:contains1""}]"	"[{""id"": ""RHEA:22889"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(R)-methylmalonyl-CoA => succinyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/22889""}]"	""
pathwaymech:KEGG_M00373_emc-065_58a3ed3e0339	RHEA:21037	RO:0002413	RHEA:45798	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21037|RHEA:45798	Material flow through acetoacetyl-CoA(4-); no enzyme channeling or physical association is implied.	"[{""reference_id"": ""RHEA:21037"", ""source_assertion"": ""This reaction produces acetoacetyl-CoA(4-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/21037 rh:products""}, {""reference_id"": ""RHEA:45798"", ""source_assertion"": ""This reaction consumes acetoacetyl-CoA(4-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/45798 rh:substrates""}]"	"[{""id"": ""RHEA:21037"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""2 acetyl-CoA => acetoacetyl-CoA + CoA"", ""url"": ""https://www.rhea-db.org/rhea/21037""}, {""id"": ""RHEA:45798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""acetoacetyl-CoA + NADPH + H(+) => (3R)-3-hydroxybutanoyl-CoA + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/45798""}]"	""
pathwaymech:KEGG_M00373_emc-066_5bc2ed5202c1	RHEA:45798	RO:0002413	RHEA:17850	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17850|RHEA:45798	Material flow through (R)-3-hydroxybutanoyl-CoA(4-); no enzyme channeling or physical association is implied.	"[{""reference_id"": ""RHEA:45798"", ""source_assertion"": ""This reaction produces (R)-3-hydroxybutanoyl-CoA(4-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/45798 rh:products""}, {""reference_id"": ""RHEA:17850"", ""source_assertion"": ""This reaction consumes (R)-3-hydroxybutanoyl-CoA(4-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/17850 rh:substrates""}]"	"[{""id"": ""RHEA:17850"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(3R)-3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"", ""url"": ""https://www.rhea-db.org/rhea/17850""}, {""id"": ""RHEA:45798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""acetoacetyl-CoA + NADPH + H(+) => (3R)-3-hydroxybutanoyl-CoA + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/45798""}]"	""
pathwaymech:KEGG_M00373_emc-067_e24e3c3b409d	RHEA:17850	RO:0002413	RHEA:28084	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17850|RHEA:28084	Material flow through crotonoyl-CoA(4-); no enzyme channeling or physical association is implied.	"[{""reference_id"": ""RHEA:17850"", ""source_assertion"": ""This reaction produces crotonoyl-CoA(4-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/17850 rh:products""}, {""reference_id"": ""RHEA:28084"", ""source_assertion"": ""This reaction consumes crotonoyl-CoA(4-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/28084 rh:substrates""}]"	"[{""id"": ""RHEA:17850"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(3R)-3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"", ""url"": ""https://www.rhea-db.org/rhea/17850""}, {""id"": ""RHEA:28084"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2E)-butenoyl-CoA + CO2 + NADPH => (2S)-ethylmalonyl-CoA + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/28084""}]"	""
pathwaymech:KEGG_M00373_emc-068_3bf2201ba208	RHEA:28084	RO:0002413	RHEA:59730	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28084|RHEA:59730	Material flow through (S)-ethylmalonyl-CoA(5-); no enzyme channeling or physical association is implied.	"[{""reference_id"": ""RHEA:28084"", ""source_assertion"": ""This reaction produces (S)-ethylmalonyl-CoA(5-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/28084 rh:products""}, {""reference_id"": ""RHEA:59730"", ""source_assertion"": ""This reaction consumes (S)-ethylmalonyl-CoA(5-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/59730 rh:substrates""}]"	"[{""id"": ""RHEA:28084"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2E)-butenoyl-CoA + CO2 + NADPH => (2S)-ethylmalonyl-CoA + NADP(+)"", ""url"": ""https://www.rhea-db.org/rhea/28084""}, {""id"": ""RHEA:59730"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2S)-ethylmalonyl-CoA => (2R)-ethylmalonyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/59730""}]"	""
pathwaymech:KEGG_M00373_emc-069_8350d08073a6	RHEA:59730	RO:0002413	RHEA:45577	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45577|RHEA:59730	Material flow through (R)-ethylmalonyl-CoA(5-); no enzyme channeling or physical association is implied.	"[{""reference_id"": ""RHEA:59730"", ""source_assertion"": ""This reaction produces (R)-ethylmalonyl-CoA(5-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/59730 rh:products""}, {""reference_id"": ""RHEA:45577"", ""source_assertion"": ""This reaction consumes (R)-ethylmalonyl-CoA(5-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/45577 rh:substrates""}]"	"[{""id"": ""RHEA:45577"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2R)-ethylmalonyl-CoA => (2S)-methylsuccinyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/45577""}, {""id"": ""RHEA:59730"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2S)-ethylmalonyl-CoA => (2R)-ethylmalonyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/59730""}]"	""
pathwaymech:KEGG_M00373_emc-070_a431e8c1cfa2	RHEA:45577	RO:0002413	RHEA:45029	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45029|RHEA:45577	Material flow through (2S)-methylsuccinyl-CoA(5-); no enzyme channeling or physical association is implied.	"[{""reference_id"": ""RHEA:45577"", ""source_assertion"": ""This reaction produces (2S)-methylsuccinyl-CoA(5-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/45577 rh:products""}, {""reference_id"": ""RHEA:45029"", ""source_assertion"": ""This reaction consumes (2S)-methylsuccinyl-CoA(5-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/45029 rh:substrates""}]"	"[{""id"": ""RHEA:45029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2S)-methylsuccinyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) => 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]"", ""url"": ""https://www.rhea-db.org/rhea/45029""}, {""id"": ""RHEA:45577"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2R)-ethylmalonyl-CoA => (2S)-methylsuccinyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/45577""}]"	""
pathwaymech:KEGG_M00373_emc-071_c67b2d3b0249	RHEA:45029	RO:0002413	RHEA:38265	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38265|RHEA:45029	Material flow through mesaconyl-CoA(5-); no enzyme channeling or physical association is implied.	"[{""reference_id"": ""RHEA:45029"", ""source_assertion"": ""This reaction produces mesaconyl-CoA(5-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/45029 rh:products""}, {""reference_id"": ""RHEA:38265"", ""source_assertion"": ""This reaction consumes mesaconyl-CoA(5-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/38265 rh:substrates""}]"	"[{""id"": ""RHEA:38265"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""2-methylfumaryl-CoA + H2O => (2R,3S)-beta-methylmalyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/38265""}, {""id"": ""RHEA:45029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2S)-methylsuccinyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) => 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]"", ""url"": ""https://www.rhea-db.org/rhea/45029""}]"	""
pathwaymech:KEGG_M00373_emc-072_8208742409e0	RHEA:38265	RO:0002413	RHEA:38260	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38260|RHEA:38265	Material flow through L-erythro-3-methylmalyl-CoA(5-); no enzyme channeling or physical association is implied.	"[{""reference_id"": ""RHEA:38265"", ""source_assertion"": ""This reaction produces L-erythro-3-methylmalyl-CoA(5-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/38265 rh:products""}, {""reference_id"": ""RHEA:38260"", ""source_assertion"": ""This reaction consumes L-erythro-3-methylmalyl-CoA(5-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/38260 rh:substrates""}]"	"[{""id"": ""RHEA:38260"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2R,3S)-beta-methylmalyl-CoA => propanoyl-CoA + glyoxylate"", ""url"": ""https://www.rhea-db.org/rhea/38260""}, {""id"": ""RHEA:38265"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""2-methylfumaryl-CoA + H2O => (2R,3S)-beta-methylmalyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/38265""}]"	""
pathwaymech:KEGG_M00373_emc-073_7a0e40245932	RHEA:38260	RO:0002413	RHEA:16631	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16631|RHEA:38260	Material flow through glyoxylate; no enzyme channeling or physical association is implied.	"[{""reference_id"": ""RHEA:38260"", ""source_assertion"": ""This reaction produces glyoxylate."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/38260 rh:products""}, {""reference_id"": ""RHEA:16631"", ""source_assertion"": ""This reaction consumes glyoxylate."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/16631 rh:substrates""}]"	"[{""id"": ""RHEA:16631"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""glyoxylate + acetyl-CoA => (S)-malyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/16631""}, {""id"": ""RHEA:38260"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2R,3S)-beta-methylmalyl-CoA => propanoyl-CoA + glyoxylate"", ""url"": ""https://www.rhea-db.org/rhea/38260""}]"	""
pathwaymech:KEGG_M00373_emc-074_9c2ef2ffb954	RHEA:16631	RO:0002413	RHEA:38292	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16631|RHEA:38292	Material flow through (3S)-3-carboxy-3-hydroxypropanoyl-CoA(5-); no enzyme channeling or physical association is implied.	"[{""reference_id"": ""RHEA:16631"", ""source_assertion"": ""This reaction produces (3S)-3-carboxy-3-hydroxypropanoyl-CoA(5-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/16631 rh:products""}, {""reference_id"": ""RHEA:38292"", ""source_assertion"": ""This reaction consumes (3S)-3-carboxy-3-hydroxypropanoyl-CoA(5-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/38292 rh:substrates""}]"	"[{""id"": ""RHEA:16631"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""glyoxylate + acetyl-CoA => (S)-malyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/16631""}, {""id"": ""RHEA:38292"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(S)-malyl-CoA + H2O => (S)-malate + CoA + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/38292""}]"	""
pathwaymech:KEGG_M00373_emc-075_12a0f9fc7d08	RHEA:38260	RO:0002413	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721|RHEA:38260	Material flow through propionyl-CoA(4-); no enzyme channeling or physical association is implied.	"[{""reference_id"": ""RHEA:38260"", ""source_assertion"": ""This reaction produces propionyl-CoA(4-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/38260 rh:products""}, {""reference_id"": ""RHEA:23721"", ""source_assertion"": ""This reaction consumes propionyl-CoA(4-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/23721 rh:substrates""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23721""}, {""id"": ""RHEA:38260"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(2R,3S)-beta-methylmalyl-CoA => propanoyl-CoA + glyoxylate"", ""url"": ""https://www.rhea-db.org/rhea/38260""}]"	""
pathwaymech:KEGG_M00373_emc-076_d5ff06847183	RHEA:23721	RO:0002413	RHEA:20555	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20555|RHEA:23721	Material flow through (S)-methylmalonyl-CoA(5-); no enzyme channeling or physical association is implied.	"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""This reaction produces (S)-methylmalonyl-CoA(5-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/23721 rh:products""}, {""reference_id"": ""RHEA:20555"", ""source_assertion"": ""This reaction consumes (S)-methylmalonyl-CoA(5-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/20555 rh:substrates""}]"	"[{""id"": ""RHEA:20555"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/20555""}, {""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""propanoyl-CoA + hydrogencarbonate + ATP => (S)-methylmalonyl-CoA + ADP + phosphate + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/23721""}]"	""
pathwaymech:KEGG_M00373_emc-077_e63574335a47	RHEA:20555	RO:0002413	RHEA:22889	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20555|RHEA:22889	Material flow through (R)-methylmalonyl-CoA(5-); no enzyme channeling or physical association is implied.	"[{""reference_id"": ""RHEA:20555"", ""source_assertion"": ""This reaction produces (R)-methylmalonyl-CoA(5-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/20555 rh:products""}, {""reference_id"": ""RHEA:22889"", ""source_assertion"": ""This reaction consumes (R)-methylmalonyl-CoA(5-)."", ""source_locator"": ""RDF subject http://rdf.rhea-db.org/22889 rh:substrates""}]"	"[{""id"": ""RHEA:20555"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/20555""}, {""id"": ""RHEA:22889"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; complete original gzip RDF retrieved 2026-10-10"", ""title"": ""(R)-methylmalonyl-CoA => succinyl-CoA"", ""url"": ""https://www.rhea-db.org/rhea/22889""}]"	""
pathwaymech:KEGG_M00373_emc-078_0dd16a80aff0	MetaCyc:CPLX-7544	BFO:0000051	UniProtKB:Q3IZ91	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7544|UniProtKB:Q3IZ91	Native species-level assembly contains 2 identical subunits. Native component xref resolves to the selected current accession (or its issued secondary accession).	"[{""reference_id"": ""MetaCyc:CPLX-7544"", ""source_assertion"": ""Native MetaCyc:CPLX-7544 lists MONOMER-13592 with coefficient 2 and species TAX-1063."", ""source_locator"": ""XML /ptools-xml/Protein[@frameid='CPLX-7544']/component[Protein/@frameid='MONOMER-13592']/coefficient; species/Organism/@frameid""}, {""reference_id"": ""UniProtKB:Q3IZ91"", ""source_assertion"": ""Homodimer; evidence ECO:0000269."", ""source_locator"": ""/comments/6; /primaryAccession; /sequence; /secondaryAccessions""}]"	"[{""id"": ""MetaCyc:CPLX-7544"", ""source_sha256"": ""06d38676593fb925bd9ed73ec4e4c2918ef75a594819ea67712d0bc6b7a3a01d"", ""source_version"": ""MetaCyc PGDB META 27.0; complete XML retrieved 2026-10-11"", ""title"": ""crotonyl-CoA carboxylase/reductase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPLX-7544""}, {""id"": ""UniProtKB:Q3IZ91"", ""source_sha256"": ""3efae38a6134a959aecf904a38f90c088b1cc1e9493a70a768f298fdeed97d1f"", ""source_version"": ""UniProt entry 109, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""Crotonyl-CoA carboxylase/reductase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3IZ91.json""}]"	""
pathwaymech:KEGG_M00373_emc-079_beb4bc31e4fa	MetaCyc:CPLX-8971	BFO:0000051	UniProtKB:D3JV03	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8971|UniProtKB:D3JV03	Native species-level assembly contains 2 identical subunits. Native component xref resolves to the selected current accession (or its issued secondary accession). Homodimer is retained as reviewed database evidence; the original cited paper was inspected only as an abstract.	"[{""reference_id"": ""MetaCyc:CPLX-8971"", ""source_assertion"": ""Native MetaCyc:CPLX-8971 lists MONOMER-19169 with coefficient 2 and species TAX-1063."", ""source_locator"": ""XML /ptools-xml/Protein[@frameid='CPLX-8971']/component[Protein/@frameid='MONOMER-19169']/coefficient; species/Organism/@frameid""}, {""reference_id"": ""UniProtKB:D3JV03"", ""source_assertion"": ""Homodimer; evidence ECO:0000269."", ""source_locator"": ""/comments/4; /primaryAccession; /sequence""}]"	"[{""id"": ""MetaCyc:CPLX-8971"", ""source_sha256"": ""4ae5d39f3b19cd6f84b749f5dafa27ca0b94e5efa2b3700414cb904ae0ad28c7"", ""source_version"": ""MetaCyc PGDB META 27.0; complete XML retrieved 2026-10-11"", ""title"": ""(2S)-methylsuccinyl-CoA dehydrogenase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPLX-8971""}, {""id"": ""UniProtKB:D3JV03"", ""source_sha256"": ""6697be882e22e97521861e8e19fa5f8cf87d174f1adf3bf079e36f931cf6e708"", ""source_version"": ""UniProt entry 51, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""(2S)-methylsuccinyl-CoA dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/D3JV03.json""}]"	""
pathwaymech:KEGG_M00373_emc-080_406c87f8dc76	MetaCyc:CPLX-8972	BFO:0000051	UniProtKB:Q3IZ90	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8972|UniProtKB:Q3IZ90	Native species-level assembly contains 2 identical subunits. Native component xref resolves to the selected current accession (or its issued secondary accession). Homodimer is retained as reviewed database evidence; the original cited paper was inspected only as an abstract.	"[{""reference_id"": ""MetaCyc:CPLX-8972"", ""source_assertion"": ""Native MetaCyc:CPLX-8972 lists MONOMER-19170 with coefficient 2 and species TAX-1063."", ""source_locator"": ""XML /ptools-xml/Protein[@frameid='CPLX-8972']/component[Protein/@frameid='MONOMER-19170']/coefficient; species/Organism/@frameid""}, {""reference_id"": ""UniProtKB:Q3IZ90"", ""source_assertion"": ""Homodimer; evidence ECO:0000269."", ""source_locator"": ""/comments/4; /primaryAccession; /sequence; /secondaryAccessions""}]"	"[{""id"": ""MetaCyc:CPLX-8972"", ""source_sha256"": ""165ab1b37fc3cbb7a15b63f231de7f7b8e2bfd6e4d1448ff5fe803dbbc83605a"", ""source_version"": ""MetaCyc PGDB META 27.0; complete XML retrieved 2026-10-11"", ""title"": ""(2R)-ethylmalonyl-CoA mutase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPLX-8972""}, {""id"": ""UniProtKB:Q3IZ90"", ""source_sha256"": ""6545b6d96f82f55142791b030d8acabf168e602a7a37488f0cca24d1a72e0e66"", ""source_version"": ""UniProt entry 101, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""Ethylmalonyl-CoA mutase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3IZ90.json""}]"	""
pathwaymech:KEGG_M00373_emc-081_28310c44a6ea	MetaCyc:CPLX-9178	BFO:0000051	UniProtKB:Q3J5L6	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-9178|PMID:24206647|UniProtKB:Q3J5L6	Native species-level assembly contains 6 identical subunits. Mcl1 exact strain/protein bridge comes from the 2010/2013 studies and matching deposited sequence; the native component has no UniProt xref.	"[{""reference_id"": ""MetaCyc:CPLX-9178"", ""source_assertion"": ""Native MetaCyc:CPLX-9178 lists MONOMER-20104 with coefficient 6 and species TAX-1063."", ""source_locator"": ""XML /ptools-xml/Protein[@frameid='CPLX-9178']/component[Protein/@frameid='MONOMER-20104']/coefficient; species/Organism/@frameid""}, {""reference_id"": ""UniProtKB:Q3J5L6"", ""source_assertion"": ""Homohexamer. Dimer of trimers; evidence ECO:0000269."", ""source_locator"": ""/comments/7; /primaryAccession; /sequence; /secondaryAccessions""}, {""reference_id"": ""PMID:24206647"", ""source_assertion"": ""MCLR from R. sphaeroides 2.4.1 was expressed as an N-terminal His10-tagged construct; structural and gel-filtration results support a hexamer, a dimer of trimers."", ""source_locator"": ""HTML section#sec7; section#sec9; section#sec18/p[2]; section#sec19/p[2]""}]"	"[{""id"": ""MetaCyc:CPLX-9178"", ""source_sha256"": ""b814da4a6bb73249642ef5572928fe8823e53c756a30627b1a6028e6dedaaef9"", ""source_version"": ""MetaCyc PGDB META 27.0; complete XML retrieved 2026-10-11"", ""title"": ""L-malyl-CoA/β-methylmalyl-CoA lyase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPLX-9178""}, {""id"": ""PMID:24206647"", ""source_sha256"": ""20377f44e3db5c8a15fb403f85be57f7a69e2fab67cfb97c42f308973c9a65b9"", ""source_version"": ""Complete original retrieved 2026-10-11; Selected Results sec7/sec9/sec10 and Methods sec18/sec19/sec20 inspected; not whole-paper or figure inspection"", ""title"": ""The crystal structures of the tri-functional Chloroflexus aurantiacus and bi-functional Rhodobacter sphaeroides malyl-CoA lyases and comparison with CitE-like superfamily enzymes and malate synthases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3832036/""}, {""id"": ""UniProtKB:Q3J5L6"", ""source_sha256"": ""305a600d1f7168ffb1a49aedc87ebfd063af447cfb156f3802f1cd6d7a553018"", ""source_version"": ""UniProt entry 111, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""L-malyl-CoA/beta-methylmalyl-CoA lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3J5L6.json""}]"	""
pathwaymech:KEGG_M00373_emc-082_bfe1741b9803	MetaCyc:CPLX-7544	pathwaymech:catalyzes	RHEA:28084	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7544|PMID:17548827|UniProtKB:Q3IZ91	Catalysis by the assembled enzyme. Exact sequence bridges and source-specific evidence tiers are retained in the research ledger.	"[{""reference_id"": ""UniProtKB:Q3IZ91"", ""source_assertion"": ""The selected gene product is assigned this catalytic reaction with ECO:0000269 evidence; directional physiological use is scoped separately from database equation orientation."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/1""}, {""reference_id"": ""MetaCyc:CPLX-7544"", ""source_assertion"": ""The native assembled protein lists its enzymatic-reaction association and described catalytic transformation."", ""source_locator"": ""XML /ptools-xml/Protein/catalyzes; /ptools-xml/Protein/comment""}, {""reference_id"": ""PMID:17548827"", ""source_assertion"": ""Purified R. sphaeroides Ccr reductively carboxylates crotonyl-CoA with NADPH; CO2 is the reactive species and metal analysis found no bound metal."", ""source_locator"": ""HTML section#sec4; section#sec16; section#sec24""}]"	"[{""id"": ""MetaCyc:CPLX-7544"", ""source_sha256"": ""06d38676593fb925bd9ed73ec4e4c2918ef75a594819ea67712d0bc6b7a3a01d"", ""source_version"": ""MetaCyc PGDB META 27.0; complete XML retrieved 2026-10-11"", ""title"": ""crotonyl-CoA carboxylase/reductase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPLX-7544""}, {""id"": ""PMID:17548827"", ""source_sha256"": ""4a9b1e01d57cdd265a342e50b24f14a68e4dd63fdf64ad8fed5c0c61e9175f5d"", ""source_version"": ""Complete original acquired; Complete main article body, methods and captions; supplementary files/diagrams not inspected. Retrieved 2026-10-11."", ""title"": ""Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: The ethylmalonyl-CoA pathway"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/17548827/""}, {""id"": ""UniProtKB:Q3IZ91"", ""source_sha256"": ""3efae38a6134a959aecf904a38f90c088b1cc1e9493a70a768f298fdeed97d1f"", ""source_version"": ""UniProt entry 109, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""Crotonyl-CoA carboxylase/reductase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3IZ91.json""}]"	""
pathwaymech:KEGG_M00373_emc-083_ae83d738a727	MetaCyc:CPLX-8972	pathwaymech:catalyzes	RHEA:45577	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8972|UniProtKB:Q3IZ90	Catalysis by the assembled enzyme. Exact sequence bridges and source-specific evidence tiers are retained in the research ledger.	"[{""reference_id"": ""UniProtKB:Q3IZ90"", ""source_assertion"": ""The selected gene product is assigned this catalytic reaction with ECO:0000269 evidence; directional physiological use is scoped separately from database equation orientation."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/1""}, {""reference_id"": ""MetaCyc:CPLX-8972"", ""source_assertion"": ""The native assembled protein lists its enzymatic-reaction association and described catalytic transformation."", ""source_locator"": ""XML /ptools-xml/Protein/catalyzes; /ptools-xml/Protein/comment""}]"	"[{""id"": ""MetaCyc:CPLX-8972"", ""source_sha256"": ""165ab1b37fc3cbb7a15b63f231de7f7b8e2bfd6e4d1448ff5fe803dbbc83605a"", ""source_version"": ""MetaCyc PGDB META 27.0; complete XML retrieved 2026-10-11"", ""title"": ""(2R)-ethylmalonyl-CoA mutase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPLX-8972""}, {""id"": ""UniProtKB:Q3IZ90"", ""source_sha256"": ""6545b6d96f82f55142791b030d8acabf168e602a7a37488f0cca24d1a72e0e66"", ""source_version"": ""UniProt entry 101, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""Ethylmalonyl-CoA mutase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3IZ90.json""}]"	""
pathwaymech:KEGG_M00373_emc-084_bc1241ba690c	MetaCyc:CPLX-8971	pathwaymech:catalyzes	RHEA:45029	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8971|NCBIProtein:ADC44452.1|PMID:29283425|UniProtKB:D3JV03	Catalysis by the assembled enzyme. Exact sequence bridges and source-specific evidence tiers are retained in the research ledger. D3JV03 matches the native 548-aa ADC44452.1 coding product, not purification tags. Its UniProt taxon is species1063; the original protein/CDS strain qualifier is 2.4.1. Q3J5V7 has seven extra N-terminal residues and is not substituted. The Rhea whole-ETF equation is a formal abstraction; observed Mcd ETF semiquinone formation is consistent with the cited ACAD-family mechanism, without directly measuring its two-ETF microscopic stoichiometry.	"[{""reference_id"": ""UniProtKB:D3JV03"", ""source_assertion"": ""The selected gene product is assigned this catalytic reaction with ECO:0000269 evidence; directional physiological use is scoped separately from database equation orientation."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/1""}, {""reference_id"": ""MetaCyc:CPLX-8971"", ""source_assertion"": ""The native assembled protein lists its enzymatic-reaction association and described catalytic transformation."", ""source_locator"": ""XML /ptools-xml/Protein/catalyzes; /ptools-xml/Protein/comment""}, {""reference_id"": ""NCBIProtein:ADC44452.1"", ""source_assertion"": ""The original versioned protein has 548 residues and source strain 2.4.1, with species taxon1063. Its entire sequence matches D3JV03; purification tags are outside this native sequence."", ""source_locator"": ""XML /GBSet/GBSeq[GBSeq_accession-version='ADC44452.1']/GBSeq_sequence; GBSeq_feature-table/GBFeature[GBFeature_key='source']/GBFeature_quals/GBQualifier[GBQualifier_name='strain']""}, {""reference_id"": ""PMID:29283425"", ""source_assertion"": ""Wild-type Mcd uses ETF and forms ETF semiquinone. The Introduction describes the ACAD-family mechanism as two successive one-electron transfers to two ETFs, citing prior work. This is consistent with Mcd observations, not a direct measurement of two-ETF microscopic stoichiometry; engineered oxygen-using Mco variants are distinct."", ""source_locator"": ""HTML section#sec1-molecules-23-00068/p[2]; section#sec2dot3-molecules-23-00068; section#sec4dot1-molecules-23-00068; section#molecules-23-00068-t001""}]"	"[{""id"": ""MetaCyc:CPLX-8971"", ""source_sha256"": ""4ae5d39f3b19cd6f84b749f5dafa27ca0b94e5efa2b3700414cb904ae0ad28c7"", ""source_version"": ""MetaCyc PGDB META 27.0; complete XML retrieved 2026-10-11"", ""title"": ""(2S)-methylsuccinyl-CoA dehydrogenase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPLX-8971""}, {""id"": ""NCBIProtein:ADC44452.1"", ""source_sha256"": ""2781da450d62838458565c2efc367208244ce2325d54de7305577bf2265cc280"", ""source_version"": ""Versioned NCBI GenBank protein XML retrieved 2026-10-11"", ""title"": ""(2S)-methylsuccinyl-CoA dehydrogenase, original 548-aa protein"", ""url"": ""https://www.ncbi.nlm.nih.gov/protein/ADC44452.1""}, {""id"": ""PMID:29283425"", ""source_sha256"": ""92a39a7536d77a990a12c9da65af1e4ad87f30c1cb13208d9f794981595daf7e"", ""source_version"": ""Complete original acquired; Relevant Introduction, Results 2.1–2.3, Methods 4.1/4.2/4.4 and Table 1 inspected; not complete article/supplement visual inspection. Retrieved 2026-10-11."", ""title"": ""Molecular Basis for Converting (2S)-Methylsuccinyl-CoA Dehydrogenase into an Oxidase"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/29283425/""}, {""id"": ""UniProtKB:D3JV03"", ""source_sha256"": ""6697be882e22e97521861e8e19fa5f8cf87d174f1adf3bf079e36f931cf6e708"", ""source_version"": ""UniProt entry 51, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""(2S)-methylsuccinyl-CoA dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/D3JV03.json""}]"	""
pathwaymech:KEGG_M00373_emc-085_741e9c46ca74	MetaCyc:CPLX-9178	pathwaymech:catalyzes	RHEA:38260	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-9178|PMID:20047909|UniProtKB:Q3J5L6	Catalysis by the assembled enzyme. Exact sequence bridges and source-specific evidence tiers are retained in the research ledger.	"[{""reference_id"": ""UniProtKB:Q3J5L6"", ""source_assertion"": ""The selected gene product is assigned this catalytic reaction with ECO:0000269 evidence; directional physiological use is scoped separately from database equation orientation."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/2""}, {""reference_id"": ""MetaCyc:CPLX-9178"", ""source_assertion"": ""The native assembled protein lists its enzymatic-reaction association and described catalytic transformation."", ""source_locator"": ""XML /ptools-xml/Protein/catalyzes; /ptools-xml/Protein/comment""}, {""reference_id"": ""PMID:20047909"", ""source_assertion"": ""Recombinant Mcl1 catalyzes beta-methylmalyl-CoA cleavage to glyoxylate and propionyl-CoA and the condensation of glyoxylate with acetyl-CoA to malyl-CoA."", ""source_locator"": ""HTML section#sec17/p[2]; section#sec17/p[3]; section#sec17/p[4]""}]"	"[{""id"": ""MetaCyc:CPLX-9178"", ""source_sha256"": ""b814da4a6bb73249642ef5572928fe8823e53c756a30627b1a6028e6dedaaef9"", ""source_version"": ""MetaCyc PGDB META 27.0; complete XML retrieved 2026-10-11"", ""title"": ""L-malyl-CoA/β-methylmalyl-CoA lyase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPLX-9178""}, {""id"": ""PMID:20047909"", ""source_sha256"": ""c4b2f3c020a6daeb4d2c7e8d6cea630c8fe864abafb511370561087be7b2be3b"", ""source_version"": ""Complete original acquired; Complete article body, methods, tables and figure captions; Figures 1 and 5 visually inspected; bibliography not systematically inspected. Retrieved 2026-10-11."", ""title"": ""The Apparent Malate Synthase Activity of Rhodobacter sphaeroides Is Due to Two Paralogous Enzymes, (3S)-Malyl-Coenzyme A (CoA)/β-Methylmalyl-CoA Lyase and (3S)- Malyl-CoA Thioesterase"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/20047909/""}, {""id"": ""UniProtKB:Q3J5L6"", ""source_sha256"": ""305a600d1f7168ffb1a49aedc87ebfd063af447cfb156f3802f1cd6d7a553018"", ""source_version"": ""UniProt entry 111, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""L-malyl-CoA/beta-methylmalyl-CoA lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3J5L6.json""}]"	""
pathwaymech:KEGG_M00373_emc-086_bce9d61101ad	MetaCyc:CPLX-9178	pathwaymech:catalyzes	RHEA:16631	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-9178|PMID:20047909|UniProtKB:Q3J5L6	Catalysis by the assembled enzyme. Exact sequence bridges and source-specific evidence tiers are retained in the research ledger.	"[{""reference_id"": ""UniProtKB:Q3J5L6"", ""source_assertion"": ""The selected gene product is assigned this catalytic reaction with ECO:0000269 evidence; directional physiological use is scoped separately from database equation orientation."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/1""}, {""reference_id"": ""MetaCyc:CPLX-9178"", ""source_assertion"": ""The native assembled protein lists its enzymatic-reaction association and described catalytic transformation."", ""source_locator"": ""XML /ptools-xml/Protein/catalyzes; /ptools-xml/Protein/comment""}, {""reference_id"": ""PMID:20047909"", ""source_assertion"": ""Recombinant Mcl1 catalyzes beta-methylmalyl-CoA cleavage to glyoxylate and propionyl-CoA and the condensation of glyoxylate with acetyl-CoA to malyl-CoA."", ""source_locator"": ""HTML section#sec17/p[2]; section#sec17/p[3]; section#sec17/p[4]""}]"	"[{""id"": ""MetaCyc:CPLX-9178"", ""source_sha256"": ""b814da4a6bb73249642ef5572928fe8823e53c756a30627b1a6028e6dedaaef9"", ""source_version"": ""MetaCyc PGDB META 27.0; complete XML retrieved 2026-10-11"", ""title"": ""L-malyl-CoA/β-methylmalyl-CoA lyase"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPLX-9178""}, {""id"": ""PMID:20047909"", ""source_sha256"": ""c4b2f3c020a6daeb4d2c7e8d6cea630c8fe864abafb511370561087be7b2be3b"", ""source_version"": ""Complete original acquired; Complete article body, methods, tables and figure captions; Figures 1 and 5 visually inspected; bibliography not systematically inspected. Retrieved 2026-10-11."", ""title"": ""The Apparent Malate Synthase Activity of Rhodobacter sphaeroides Is Due to Two Paralogous Enzymes, (3S)-Malyl-Coenzyme A (CoA)/β-Methylmalyl-CoA Lyase and (3S)- Malyl-CoA Thioesterase"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/20047909/""}, {""id"": ""UniProtKB:Q3J5L6"", ""source_sha256"": ""305a600d1f7168ffb1a49aedc87ebfd063af447cfb156f3802f1cd6d7a553018"", ""source_version"": ""UniProt entry 111, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""L-malyl-CoA/beta-methylmalyl-CoA lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3J5L6.json""}]"	""
pathwaymech:KEGG_M00373_emc-087_2e665d2789d1	UniProtKB:Q3IZP4	pathwaymech:catalyzes	RHEA:59730	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q3IZP4	One promiscuous epimerase supports the ethylmalonyl-CoA epimerization.	"[{""reference_id"": ""UniProtKB:Q3IZP4"", ""source_assertion"": ""The reviewed entry assigns this reaction with ECO:0000269 evidence; its deposited primary sequence matches the current selected sequence. The cited 2008 mutase paper is available here only as an abstract when applicable."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/1""}]"	"[{""id"": ""UniProtKB:Q3IZP4"", ""source_sha256"": ""85c4248244f074857dd1e12521ba12986da454ed9e71f5e3ab1d43895d772b0f"", ""source_version"": ""UniProt entry 93, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""Ethylmalonyl-CoA/methylmalonyl-CoA epimerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3IZP4.json""}]"	""
pathwaymech:KEGG_M00373_emc-088_f6859470f71f	UniProtKB:Q3IZP4	pathwaymech:catalyzes	RHEA:20555	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q3IZP4	The same epimerase supports the methylmalonyl-CoA branch.	"[{""reference_id"": ""UniProtKB:Q3IZP4"", ""source_assertion"": ""The reviewed entry assigns this reaction with ECO:0000269 evidence; its deposited primary sequence matches the current selected sequence. The cited 2008 mutase paper is available here only as an abstract when applicable."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/2""}]"	"[{""id"": ""UniProtKB:Q3IZP4"", ""source_sha256"": ""85c4248244f074857dd1e12521ba12986da454ed9e71f5e3ab1d43895d772b0f"", ""source_version"": ""UniProt entry 93, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""Ethylmalonyl-CoA/methylmalonyl-CoA epimerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3IZP4.json""}]"	""
pathwaymech:KEGG_M00373_emc-089_1e185035bba7	UniProtKB:Q3IZ78	pathwaymech:catalyzes	RHEA:38265	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:18065535|UniProtKB:Q3IZ78	Mesaconyl-C1-CoA hydration in this pathway; the reverse dehydration is used in the distinct Chloroflexus pathway. Recombinant enzyme was an approximately 80-kDa homodimer.	"[{""reference_id"": ""UniProtKB:Q3IZ78"", ""source_assertion"": ""The reviewed entry assigns this reaction with ECO:0000269 evidence; its deposited primary sequence matches the current selected sequence. The cited 2008 mutase paper is available here only as an abstract when applicable."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/1""}, {""reference_id"": ""PMID:18065535"", ""source_assertion"": ""Recombinant R. sphaeroides mesaconyl-CoA hydratase converts beta-methylmalyl-CoA and mesaconyl-CoA reversibly; NMR locates the CoA thioester at mesaconate C1, and its EMC role is hydration."", ""source_locator"": ""HTML section#sec24; section#sec35; section#sec36; section#sec40""}]"	"[{""id"": ""PMID:18065535"", ""source_sha256"": ""881030aafa223395064e045a5974a6aaca611f503847ee825e3187e868d12aec"", ""source_version"": ""Complete original acquired; Complete main article body, methods, Table 1 and captions; diagrams not visually inspected. Retrieved 2026-10-11."", ""title"": ""Mesaconyl-Coenzyme A Hydratase, a New Enzyme of Two Central Carbon Metabolic Pathways in Bacteria"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/18065535/""}, {""id"": ""UniProtKB:Q3IZ78"", ""source_sha256"": ""62bdcf7b8f232e1fa4b401b152ba71f23dfcff2e87cd829406e618e3699d87f3"", ""source_version"": ""UniProt entry 89, sequence 1, annotation 2026-06-10; original retrieved 2026-10-11"", ""title"": ""Mesaconyl-CoA hydratase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3IZ78.json""}]"	""
pathwaymech:KEGG_M00373_emc-090_82f512a409c5	UniProtKB:D3JV05	pathwaymech:catalyzes	RHEA:38292	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:20047909|UniProtKB:D3JV05	Mcl2 hydrolyzes malyl-CoA without ATP formation. It is not Mcl1, not a beta-methylmalyl-CoA hydrolase, and not reversed malate-CoA ligase. Gel filtration leaves dimer versus trimer unresolved.	"[{""reference_id"": ""UniProtKB:D3JV05"", ""source_assertion"": ""The reviewed entry assigns this reaction with ECO:0000269 evidence; its deposited primary sequence matches the current selected sequence. The cited 2008 mutase paper is available here only as an abstract when applicable."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/1""}, {""reference_id"": ""PMID:20047909"", ""source_assertion"": ""Purified His-tagged Mcl2 hydrolyzes malyl-CoA to malate and CoA, but does not cleave malyl-CoA or beta-methylmalyl-CoA; 80-kDa gel filtration supports an unresolved dimer or trimer."", ""source_locator"": ""HTML section#sec19/p[1]""}]"	"[{""id"": ""PMID:20047909"", ""source_sha256"": ""c4b2f3c020a6daeb4d2c7e8d6cea630c8fe864abafb511370561087be7b2be3b"", ""source_version"": ""Complete original acquired; Complete article body, methods, tables and figure captions; Figures 1 and 5 visually inspected; bibliography not systematically inspected. Retrieved 2026-10-11."", ""title"": ""The Apparent Malate Synthase Activity of Rhodobacter sphaeroides Is Due to Two Paralogous Enzymes, (3S)-Malyl-Coenzyme A (CoA)/β-Methylmalyl-CoA Lyase and (3S)- Malyl-CoA Thioesterase"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/20047909/""}, {""id"": ""UniProtKB:D3JV05"", ""source_sha256"": ""903fb205888bdd0aa5d5db8f99832b35ca89eebb59326fea81541f9e5be448b7"", ""source_version"": ""UniProt entry 78, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""(3S)-malyl-CoA thioesterase"", ""url"": ""https://rest.uniprot.org/uniprotkb/D3JV05.json""}]"	""
pathwaymech:KEGG_M00373_emc-091_a45be021018a	UniProtKB:Q3J4D7	pathwaymech:catalyzes	RHEA:22889	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q3J4D7	Methylmalonyl-CoA mutase closes the propionyl branch at succinyl-CoA. Its homodimer annotation is by similarity, not a measured assembly in this strain.	"[{""reference_id"": ""UniProtKB:Q3J4D7"", ""source_assertion"": ""The reviewed entry assigns this reaction with ECO:0000269 evidence; its deposited primary sequence matches the current selected sequence. The cited 2008 mutase paper is available here only as an abstract when applicable."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/1""}]"	"[{""id"": ""UniProtKB:Q3J4D7"", ""source_sha256"": ""0079c5c80b4047a4c2952725e9a891c0f3b297cd007827ae69acc7d39db44388"", ""source_version"": ""UniProt entry 104, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""Methylmalonyl-CoA mutase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3J4D7.json""}]"	""
pathwaymech:KEGG_M00373_emc-092_70e011289f96	UniProtKB:Q3IZW1	pathwaymech:enables	RHEA:21037	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q3IZW1	Candidate thiolase assignment is automatic and does not demonstrate that this is the sole strain thiolase used by the pathway.	"[{""reference_id"": ""UniProtKB:Q3IZW1"", ""source_assertion"": ""The unreviewed protein is assigned acetyl-CoA C-acetyltransferase activity, RHEA:21036, with ECO:0000256 PROSITE-ProRule PRU10020 evidence."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/0""}]"	"[{""id"": ""UniProtKB:Q3IZW1"", ""source_sha256"": ""567cdf32ea194c33cc485bf6a2808ed997f18da66962a891c3cb210f88b23a40"", ""source_version"": ""UniProt entry 120, sequence 2, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""Acetyl-CoA C-acetyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3IZW1.json""}]"	""
pathwaymech:KEGG_M00373_emc-093_0f8dc3ffe0a9	UniProtKB:Q3J4D9	pathwaymech:enables	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00373|UniProtKB:Q3J4D9	Subunit contribution to the combined propionyl-CoA carboxylase reaction; this edge does not assert that the isolated chain performs the entire reaction. No measured six-alpha/six-beta assembly is claimed.	"[{""reference_id"": ""UniProtKB:Q3J4D9"", ""source_assertion"": ""Alpha-chain catalytic assignment is automatic ECO:0000256 ARBA00049495; KEGG requires K01965 together with K01966."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/0""}, {""reference_id"": ""KEGG:M00373"", ""source_assertion"": ""K01965+K01966 is a joint mandatory module requirement for propionyl-CoA carboxylase."", ""source_locator"": ""ENTRY M00373 / DEFINITION; ORTHOLOGY K01965 and K01966""}]"	"[{""id"": ""KEGG:M00373"", ""source_sha256"": ""7a191e66d0acdfa35d76713ff136f4240f8626a1d8369207882d3dc7a3965e44"", ""source_version"": ""Complete module flatfile retrieved 2026-10-11; no release number supplied"", ""title"": ""Ethylmalonyl pathway"", ""url"": ""https://rest.kegg.jp/get/M00373""}, {""id"": ""UniProtKB:Q3J4D9"", ""source_sha256"": ""56ab2eff1788a043cc4c27e020c76090bdc6f44aecc45acf133a19d031845665"", ""source_version"": ""UniProt entry 125, sequence 2, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""propionyl-CoA carboxylase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3J4D9.json""}]"	""
pathwaymech:KEGG_M00373_emc-094_904717d0949d	UniProtKB:Q3J4E3	pathwaymech:enables	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	KEGG:M00373|UniProtKB:Q3J4E3	Subunit contribution to the combined propionyl-CoA carboxylase reaction; this edge does not assert that the isolated chain performs the entire reaction. No measured six-alpha/six-beta assembly is claimed.	"[{""reference_id"": ""UniProtKB:Q3J4E3"", ""source_assertion"": ""The beta-chain entry assigns propionyl-CoA carboxylase activity with ECO:0000269 PMID26170412; that paper measures cellular enzyme activity and pccB expression, not purified-chain overall catalysis."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/0""}, {""reference_id"": ""KEGG:M00373"", ""source_assertion"": ""K01965+K01966 is a joint mandatory module requirement for propionyl-CoA carboxylase."", ""source_locator"": ""ENTRY M00373 / DEFINITION; ORTHOLOGY K01965 and K01966""}]"	"[{""id"": ""KEGG:M00373"", ""source_sha256"": ""7a191e66d0acdfa35d76713ff136f4240f8626a1d8369207882d3dc7a3965e44"", ""source_version"": ""Complete module flatfile retrieved 2026-10-11; no release number supplied"", ""title"": ""Ethylmalonyl pathway"", ""url"": ""https://rest.kegg.jp/get/M00373""}, {""id"": ""UniProtKB:Q3J4E3"", ""source_sha256"": ""eae7e41ff8268e80471cc9a5e7a0483763866baa53bfe36e6b45a89cfcbf63a4"", ""source_version"": ""UniProt entry 92, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""Propionyl-CoA carboxylase beta chain"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3J4E3.json""}]"	""
pathwaymech:KEGG_M00373_emc-095_fed9d8a538ba	UniProtKB:Q3IZ90	pathwaymech:has_cofactor	CHEBI:18408	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q3IZ90	Reviewed experimental annotation; original mutase full text unavailable.	"[{""reference_id"": ""UniProtKB:Q3IZ90"", ""source_assertion"": ""The cofactor statement names cobamamide (CHEBI:18408); evidence ECO:0000269. Reviewed experimental annotation; original mutase full text unavailable."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/2""}]"	"[{""id"": ""UniProtKB:Q3IZ90"", ""source_sha256"": ""6545b6d96f82f55142791b030d8acabf168e602a7a37488f0cca24d1a72e0e66"", ""source_version"": ""UniProt entry 101, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""Ethylmalonyl-CoA mutase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3IZ90.json""}]"	""
pathwaymech:KEGG_M00373_emc-096_15cffb7caafa	UniProtKB:Q3J4D7	pathwaymech:has_cofactor	CHEBI:18408	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q3J4D7	Reviewed experimental annotation; original mutase full text unavailable.	"[{""reference_id"": ""UniProtKB:Q3J4D7"", ""source_assertion"": ""The cofactor statement names cobamamide (CHEBI:18408); evidence ECO:0000269. Reviewed experimental annotation; original mutase full text unavailable."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/2""}]"	"[{""id"": ""UniProtKB:Q3J4D7"", ""source_sha256"": ""0079c5c80b4047a4c2952725e9a891c0f3b297cd007827ae69acc7d39db44388"", ""source_version"": ""UniProt entry 104, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""Methylmalonyl-CoA mutase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3J4D7.json""}]"	""
pathwaymech:KEGG_M00373_emc-097_a3f2aff7313e	UniProtKB:Q3IZP4	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q3IZP4	Alternative supporting ions, not simultaneous occupancy or a demonstrated physiological metal; Mg and Ni do not support activity in the cited assays.	"[{""reference_id"": ""UniProtKB:Q3IZP4"", ""source_assertion"": ""The cofactor statement names cobalt(2+) (CHEBI:48828); evidence ECO:0000269. Alternative supporting ions, not simultaneous occupancy or a demonstrated physiological metal; Mg and Ni do not support activity in the cited assays."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/3""}]"	"[{""id"": ""UniProtKB:Q3IZP4"", ""source_sha256"": ""85c4248244f074857dd1e12521ba12986da454ed9e71f5e3ab1d43895d772b0f"", ""source_version"": ""UniProt entry 93, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""Ethylmalonyl-CoA/methylmalonyl-CoA epimerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3IZP4.json""}]"	""
pathwaymech:KEGG_M00373_emc-098_333c52edb277	UniProtKB:Q3IZP4	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q3IZP4	Alternative supporting ions, not simultaneous occupancy or a demonstrated physiological metal; Mg and Ni do not support activity in the cited assays.	"[{""reference_id"": ""UniProtKB:Q3IZP4"", ""source_assertion"": ""The cofactor statement names manganese(2+) (CHEBI:29035); evidence ECO:0000269. Alternative supporting ions, not simultaneous occupancy or a demonstrated physiological metal; Mg and Ni do not support activity in the cited assays."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/3""}]"	"[{""id"": ""UniProtKB:Q3IZP4"", ""source_sha256"": ""85c4248244f074857dd1e12521ba12986da454ed9e71f5e3ab1d43895d772b0f"", ""source_version"": ""UniProt entry 93, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""Ethylmalonyl-CoA/methylmalonyl-CoA epimerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3IZP4.json""}]"	""
pathwaymech:KEGG_M00373_emc-099_f104726418f6	UniProtKB:D3JV03	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:D3JV03	Bound FAD, one per subunit in the reviewed source. This is distinct from the separate whole ETF electron-acceptor states.	"[{""reference_id"": ""UniProtKB:D3JV03"", ""source_assertion"": ""The cofactor statement names FAD(3-) (CHEBI:57692); evidence ECO:0000269. Bound FAD, one per subunit in the reviewed source. This is distinct from the separate whole ETF electron-acceptor states."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/2""}]"	"[{""id"": ""UniProtKB:D3JV03"", ""source_sha256"": ""6697be882e22e97521861e8e19fa5f8cf87d174f1adf3bf079e36f931cf6e708"", ""source_version"": ""UniProt entry 51, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""(2S)-methylsuccinyl-CoA dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/D3JV03.json""}]"	""
pathwaymech:KEGG_M00373_emc-100_00e8b506ea42	UniProtKB:Q3J4D9	pathwaymech:has_cofactor	CHEBI:57586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q3J4D9	Automatic ARBA annotation of biotin-dependent alpha-chain function, not direct measurement in this strain.	"[{""reference_id"": ""UniProtKB:Q3J4D9"", ""source_assertion"": ""The cofactor statement names biotinate (CHEBI:57586); evidence ECO:0000256. Automatic ARBA annotation of biotin-dependent alpha-chain function, not direct measurement in this strain."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/1""}]"	"[{""id"": ""UniProtKB:Q3J4D9"", ""source_sha256"": ""56ab2eff1788a043cc4c27e020c76090bdc6f44aecc45acf133a19d031845665"", ""source_version"": ""UniProt entry 125, sequence 2, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""propionyl-CoA carboxylase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3J4D9.json""}]"	""
pathwaymech:KEGG_M00373_emc-101_d849d37acf5c	UniProtKB:Q3J5L6	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:20047909|UniProtKB:Q3J5L6	Alternative divalent-ion assay support; Mn performed best after EDTA pretreatment. Mg-containing crystals do not establish exclusive physiological Mg use.	"[{""reference_id"": ""UniProtKB:Q3J5L6"", ""source_assertion"": ""The cofactor statement names magnesium(2+) (CHEBI:18420); evidence ECO:0000269. Alternative divalent-ion assay support; Mn performed best after EDTA pretreatment. Mg-containing crystals do not establish exclusive physiological Mg use."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/4""}, {""reference_id"": ""PMID:20047909"", ""source_assertion"": ""Divalent cations support activity after EDTA treatment; Mcl1 favors Mn whereas Mcl2 favors Mg under the reported assays. These assays do not determine exclusive physiological occupancy."", ""source_locator"": ""HTML section#sec17/p[3]; section#sec19/p[1]; section#t1""}]"	"[{""id"": ""PMID:20047909"", ""source_sha256"": ""c4b2f3c020a6daeb4d2c7e8d6cea630c8fe864abafb511370561087be7b2be3b"", ""source_version"": ""Complete original acquired; Complete article body, methods, tables and figure captions; Figures 1 and 5 visually inspected; bibliography not systematically inspected. Retrieved 2026-10-11."", ""title"": ""The Apparent Malate Synthase Activity of Rhodobacter sphaeroides Is Due to Two Paralogous Enzymes, (3S)-Malyl-Coenzyme A (CoA)/β-Methylmalyl-CoA Lyase and (3S)- Malyl-CoA Thioesterase"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/20047909/""}, {""id"": ""UniProtKB:Q3J5L6"", ""source_sha256"": ""305a600d1f7168ffb1a49aedc87ebfd063af447cfb156f3802f1cd6d7a553018"", ""source_version"": ""UniProt entry 111, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""L-malyl-CoA/beta-methylmalyl-CoA lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3J5L6.json""}]"	""
pathwaymech:KEGG_M00373_emc-102_3bdddd487d54	UniProtKB:Q3J5L6	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:20047909|UniProtKB:Q3J5L6	Alternative divalent-ion assay support; Mn performed best after EDTA pretreatment. Mg-containing crystals do not establish exclusive physiological Mg use.	"[{""reference_id"": ""UniProtKB:Q3J5L6"", ""source_assertion"": ""The cofactor statement names manganese(2+) (CHEBI:29035); evidence ECO:0000269. Alternative divalent-ion assay support; Mn performed best after EDTA pretreatment. Mg-containing crystals do not establish exclusive physiological Mg use."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/4""}, {""reference_id"": ""PMID:20047909"", ""source_assertion"": ""Divalent cations support activity after EDTA treatment; Mcl1 favors Mn whereas Mcl2 favors Mg under the reported assays. These assays do not determine exclusive physiological occupancy."", ""source_locator"": ""HTML section#sec17/p[3]; section#sec19/p[1]; section#t1""}]"	"[{""id"": ""PMID:20047909"", ""source_sha256"": ""c4b2f3c020a6daeb4d2c7e8d6cea630c8fe864abafb511370561087be7b2be3b"", ""source_version"": ""Complete original acquired; Complete article body, methods, tables and figure captions; Figures 1 and 5 visually inspected; bibliography not systematically inspected. Retrieved 2026-10-11."", ""title"": ""The Apparent Malate Synthase Activity of Rhodobacter sphaeroides Is Due to Two Paralogous Enzymes, (3S)-Malyl-Coenzyme A (CoA)/β-Methylmalyl-CoA Lyase and (3S)- Malyl-CoA Thioesterase"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/20047909/""}, {""id"": ""UniProtKB:Q3J5L6"", ""source_sha256"": ""305a600d1f7168ffb1a49aedc87ebfd063af447cfb156f3802f1cd6d7a553018"", ""source_version"": ""UniProt entry 111, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""L-malyl-CoA/beta-methylmalyl-CoA lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3J5L6.json""}]"	""
pathwaymech:KEGG_M00373_emc-103_5263b03b2615	UniProtKB:D3JV05	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:20047909|UniProtKB:D3JV05	Mg supported thioester hydrolysis best at 10 mM in the primary assay; not a measured in vivo metal assignment.	"[{""reference_id"": ""UniProtKB:D3JV05"", ""source_assertion"": ""The cofactor statement names magnesium(2+) (CHEBI:18420); evidence ECO:0000269. Mg supported thioester hydrolysis best at 10 mM in the primary assay; not a measured in vivo metal assignment."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/2""}, {""reference_id"": ""PMID:20047909"", ""source_assertion"": ""Divalent cations support activity after EDTA treatment; Mcl1 favors Mn whereas Mcl2 favors Mg under the reported assays. These assays do not determine exclusive physiological occupancy."", ""source_locator"": ""HTML section#sec17/p[3]; section#sec19/p[1]; section#t1""}]"	"[{""id"": ""PMID:20047909"", ""source_sha256"": ""c4b2f3c020a6daeb4d2c7e8d6cea630c8fe864abafb511370561087be7b2be3b"", ""source_version"": ""Complete original acquired; Complete article body, methods, tables and figure captions; Figures 1 and 5 visually inspected; bibliography not systematically inspected. Retrieved 2026-10-11."", ""title"": ""The Apparent Malate Synthase Activity of Rhodobacter sphaeroides Is Due to Two Paralogous Enzymes, (3S)-Malyl-Coenzyme A (CoA)/β-Methylmalyl-CoA Lyase and (3S)- Malyl-CoA Thioesterase"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/20047909/""}, {""id"": ""UniProtKB:D3JV05"", ""source_sha256"": ""903fb205888bdd0aa5d5db8f99832b35ca89eebb59326fea81541f9e5be448b7"", ""source_version"": ""UniProt entry 78, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""(3S)-malyl-CoA thioesterase"", ""url"": ""https://rest.uniprot.org/uniprotkb/D3JV05.json""}]"	""
pathwaymech:KEGG_M00373_emc-104_b6d8020ff42e	UniProtKB:D3JV05	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:20047909	Mn is an alternative divalent-ion assay activator; Mg at 10 mM served best. Do not infer simultaneous Mn/Mg occupancy.	"[{""reference_id"": ""PMID:20047909"", ""source_assertion"": ""Purified Mcl2 activity was supported by Mg or Mn; testing after EDTA pretreatment found Mg at 10 mM best."", ""source_locator"": ""HTML section#sec19/p[1]; section#t1""}]"	"[{""id"": ""PMID:20047909"", ""source_sha256"": ""c4b2f3c020a6daeb4d2c7e8d6cea630c8fe864abafb511370561087be7b2be3b"", ""source_version"": ""Complete original acquired; Complete article body, methods, tables and figure captions; Figures 1 and 5 visually inspected; bibliography not systematically inspected. Retrieved 2026-10-11."", ""title"": ""The Apparent Malate Synthase Activity of Rhodobacter sphaeroides Is Due to Two Paralogous Enzymes, (3S)-Malyl-Coenzyme A (CoA)/β-Methylmalyl-CoA Lyase and (3S)- Malyl-CoA Thioesterase"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/20047909/""}]"	""
pathwaymech:KEGG_M00373_emc-105_e1c2811ca1b7	UniProtKB:Q3J4E6	pathwaymech:regulates	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:26170412|UniProtKB:Q3J4E6	Indirect transcriptional control of the PCC step through pccB expression. Direct DNA binding was not established; propionyl-CoA as the PccR ligand was proposed rather than measured. The deletion retained acetate growth.	"[{""reference_id"": ""PMID:26170412"", ""source_assertion"": ""Deleting pccR removed carbon-source-dependent pccB transcript and cellular PCC-activity regulation. Complementation restored propionate growth and cellular PCC activity; restored transcription was not measured. Soluble PccR purification failed, so direct promoter binding was not demonstrated."", ""source_locator"": ""HTML section#sec3-3; section#T1; section#sec3-1; section#sec4/p[1]""}, {""reference_id"": ""UniProtKB:Q3J4E6"", ""source_assertion"": ""PccR controls propionyl-CoA assimilation through regulation of pccB expression, with ECO:0000269 PMID26170412 evidence."", ""source_locator"": ""JSON /primaryAccession; /organism/taxonId; /comments/0""}]"	"[{""id"": ""PMID:26170412"", ""source_sha256"": ""c8715fbfc2c36bd045e1ebd0d05c7a34410bf4c9e9af47daae901f604639b470"", ""source_version"": ""Complete original retrieved 2026-10-11; Complete main body, methods, tables and captions inspected; supplements and figures not visually inspected"", ""title"": ""Transcriptional Regulation by the Short-Chain Fatty Acyl Coenzyme A Regulator (ScfR) PccR Controls Propionyl Coenzyme A Assimilation by Rhodobacter sphaeroides"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC4560284/""}, {""id"": ""UniProtKB:Q3J4E6"", ""source_sha256"": ""095745f904aab8e20e53f3208885570bd528e49c5b32a6fb1ee26f5ecf350216"", ""source_version"": ""UniProt entry 101, sequence 1, annotation 2026-09-02; original retrieved 2026-10-11"", ""title"": ""Propionyl-CoA carboxylase regulator"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q3J4E6.json""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-001_0088b9f73e6f	gomodel:3-OXOACYL-ACP-REDUCT-RXN	BFO:0000050	GO:0030497	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-OXOACYL-ACP-REDUCT-RXN BFO:0000050 gomodel:YeastPathways_FASYN-ELONG2-PWY/YeastPathways_FASYN-ELONG2-PWY."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/0; endpoint types: /individuals/66/type; /individuals/68/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-002_1beb2e775e5a	gomodel:3-OXOACYL-ACP-REDUCT-RXN	RO:0002233	CHEBI:2393	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-OXOACYL-ACP-REDUCT-RXN RO:0002233 gomodel:B-KETOACYL-ACP_3-OXOACYL-ACP-SYNTH-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/1; endpoint types: /individuals/66/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-003_12912537625e	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411	RO:0002234	CHEBI:13534	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 RO:0002234 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003414."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/2; endpoint types: /individuals/74/type; /individuals/77/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-004_9b18a1c0a2a8	gomodel:3-OXOACYL-ACP-REDUCT-RXN	RO:0002413	gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-OXOACYL-ACP-REDUCT-RXN RO:0002413 gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/3; endpoint types: /individuals/66/type; /individuals/65/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-005_38a92e49c6d7	gomodel:PALMITOYL-COA-HYDROLASE-RXN	BFO:0000050	GO:0030497	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:PALMITOYL-COA-HYDROLASE-RXN BFO:0000050 gomodel:YeastPathways_FASYN-ELONG2-PWY/YeastPathways_FASYN-ELONG2-PWY."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/4; endpoint types: /individuals/18/type; /individuals/68/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-006_04547f1eeb31	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 RO:0002233 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003412."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/5; endpoint types: /individuals/74/type; /individuals/75/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-007_99fd6461784f	gomodel:ENOYL-ACP-REDUCT-NADPH-RXN	RO:0002413	gomodel:RXN3O-9780	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ENOYL-ACP-REDUCT-NADPH-RXN RO:0002413 gomodel:RXN3O-9780."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/6; endpoint types: /individuals/16/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-008_d86306bc61fb	gomodel:ENOYL-ACP-REDUCT-NADPH-RXN	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ENOYL-ACP-REDUCT-NADPH-RXN RO:0002234 gomodel:CHEBI_58349_ENOYL-ACP-REDUCT-NADPH-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/7; endpoint types: /individuals/16/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-009_513bb133373b	gomodel:3-OXOACYL-ACP-REDUCT-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-OXOACYL-ACP-REDUCT-RXN BFO:0000066 gomodel:reaction_3-OXOACYL-ACP-REDUCT-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/8; endpoint types: /individuals/66/type; /individuals/60/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-010_8b2f0939bf3b	SGD:S000006152	pathwaymech:enables	gomodel:3-OXOACYL-ACP-REDUCT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-OXOACYL-ACP-REDUCT-RXN RO:0002333 gomodel:YPL231W-MONOMER_3-OXOACYL-ACP-REDUCT-RXN_controller."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/9; endpoint types: /individuals/66/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-011_a88e87d36b4a	SGD:S000001538	pathwaymech:enables	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428 RO:0002333 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003433."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/10; endpoint types: /individuals/90/type; /individuals/94/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-012_3a92e4ab1210	gomodel:ENOYL-ACP-REDUCT-NADPH-RXN	BFO:0000050	GO:0030497	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ENOYL-ACP-REDUCT-NADPH-RXN BFO:0000050 gomodel:YeastPathways_FASYN-ELONG2-PWY/YeastPathways_FASYN-ELONG2-PWY."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/11; endpoint types: /individuals/16/type; /individuals/68/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-013_06faa33fc463	gomodel:PALMITOYL-COA-HYDROLASE-RXN	RO:0002234	CHEBI:7896	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:PALMITOYL-COA-HYDROLASE-RXN RO:0002234 gomodel:CHEBI_7896_PALMITOYL-COA-HYDROLASE-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/12; endpoint types: /individuals/18/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-014_892b89d02a6d	gomodel:ENOYL-ACP-REDUCT-NADPH-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ENOYL-ACP-REDUCT-NADPH-RXN BFO:0000066 gomodel:reaction_ENOYL-ACP-REDUCT-NADPH-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/13; endpoint types: /individuals/16/type; /individuals/62/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-015_d934fea9700f	gomodel:3-OXOACYL-ACP-REDUCT-RXN	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-OXOACYL-ACP-REDUCT-RXN RO:0002234 gomodel:CHEBI_58349_3-OXOACYL-ACP-REDUCT-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/14; endpoint types: /individuals/66/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-016_1f68598b4e98	gomodel:RXN3O-9780	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9780 BFO:0000066 gomodel:reaction_RXN3O-9780_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/15; endpoint types: /individuals/19/type; /individuals/64/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-017_55af8565a140	gomodel:PALMITOYL-COA-HYDROLASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:PALMITOYL-COA-HYDROLASE-RXN RO:0002233 gomodel:CHEBI_15377_PALMITOYL-COA-HYDROLASE-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/16; endpoint types: /individuals/18/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-018_c4d231ca0be5	gomodel:3-OXOACYL-ACP-SYNTH-RXN	RO:0002234	CHEBI:13534	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-OXOACYL-ACP-SYNTH-RXN RO:0002234 gomodel:YeastPathways_FASYN-ELONG2-PWY/6690711d00001620."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/17; endpoint types: /individuals/67/type; /individuals/111/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-019_5f499b1002f3	gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN	RO:0002233	CHEBI:84648	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN RO:0002233 gomodel:OH-ACYL-ACP_3-OXOACYL-ACP-REDUCT-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/18; endpoint types: /individuals/65/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-020_a81051170b08	SGD:S000000863	pathwaymech:enables	gomodel:3-OXOACYL-ACP-SYNTH-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-OXOACYL-ACP-SYNTH-RXN RO:0002333 gomodel:YER061C-MONOMER_3-OXOACYL-ACP-SYNTH-RXN_controller."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/19; endpoint types: /individuals/67/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-021_bd3f1a511292	gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN BFO:0000066 gomodel:reaction_3-HYDROXYDECANOYL-ACP-DEHYDR-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/20; endpoint types: /individuals/65/type; /individuals/59/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-023_df6fa3ce18ab	SGD:S000001665	pathwaymech:enables	gomodel:RXN3O-9780	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9780 RO:0002333 gomodel:YKL182W-MONOMER_RXN3O-9780_controller."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/22; endpoint types: /individuals/19/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-024_073b9888a567	gomodel:3-OXOACYL-ACP-SYNTH-RXN	RO:0002413	gomodel:3-OXOACYL-ACP-REDUCT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-OXOACYL-ACP-SYNTH-RXN RO:0002413 gomodel:3-OXOACYL-ACP-REDUCT-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/23; endpoint types: /individuals/67/type; /individuals/66/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-025_71e3468de16e	gomodel:RXN3O-9780	BFO:0000050	GO:0030497	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9780 BFO:0000050 gomodel:YeastPathways_FASYN-ELONG2-PWY/YeastPathways_FASYN-ELONG2-PWY."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/24; endpoint types: /individuals/19/type; /individuals/68/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-026_b0eab6693e3b	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428	BFO:0000050	GO:0030497	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428 BFO:0000050 gomodel:YeastPathways_FASYN-ELONG2-PWY/YeastPathways_FASYN-ELONG2-PWY."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/25; endpoint types: /individuals/90/type; /individuals/68/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-027_0fd89e975332	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411	RO:0002413	gomodel:3-OXOACYL-ACP-REDUCT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 RO:0002413 gomodel:3-OXOACYL-ACP-REDUCT-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/26; endpoint types: /individuals/74/type; /individuals/66/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-028_070ab41af46c	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 BFO:0000066 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003418."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/27; endpoint types: /individuals/74/type; /individuals/80/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-029_94fe16f9fd62	gomodel:3-OXOACYL-ACP-SYNTH-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-OXOACYL-ACP-SYNTH-RXN RO:0002233 gomodel:CHEBI_15378_3-OXOACYL-ACP-SYNTH-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/28; endpoint types: /individuals/67/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-030_c688be522393	gomodel:3-OXOACYL-ACP-SYNTH-RXN	RO:0002234	CHEBI:2393	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-OXOACYL-ACP-SYNTH-RXN RO:0002234 gomodel:B-KETOACYL-ACP_3-OXOACYL-ACP-SYNTH-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/29; endpoint types: /individuals/67/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-031_88093d574a12	gomodel:PALMITOYL-COA-HYDROLASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:PALMITOYL-COA-HYDROLASE-RXN RO:0002234 gomodel:CHEBI_15378_PALMITOYL-COA-HYDROLASE-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/30; endpoint types: /individuals/18/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-032_23e3dec68c88	gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN	RO:0002234	CHEBI:16018	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN RO:0002234 gomodel:TRANS-D2-ENOYL-ACP_3-HYDROXYDECANOYL-ACP-DEHYDR-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/31; endpoint types: /individuals/65/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-034_c2056e43675e	gomodel:PALMITOYL-COA-HYDROLASE-RXN	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:PALMITOYL-COA-HYDROLASE-RXN RO:0002234 gomodel:CHEBI_57287_PALMITOYL-COA-HYDROLASE-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/33; endpoint types: /individuals/18/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-035_a4f07e0aad26	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411	RO:0002234	CHEBI:2393	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 RO:0002234 gomodel:B-KETOACYL-ACP_3-OXOACYL-ACP-SYNTH-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/34; endpoint types: /individuals/74/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-036_975817621777	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428	RO:0002413	gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428 RO:0002413 gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/35; endpoint types: /individuals/90/type; /individuals/65/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-037_5578d21d0e8b	gomodel:3-OXOACYL-ACP-REDUCT-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-OXOACYL-ACP-REDUCT-RXN RO:0002233 gomodel:CHEBI_15378_3-OXOACYL-ACP-REDUCT-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/36; endpoint types: /individuals/66/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-038_42028d1bb1cf	gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN RO:0002234 gomodel:CHEBI_15377_3-HYDROXYDECANOYL-ACP-DEHYDR-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/37; endpoint types: /individuals/65/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-039_08c75bd539e3	gomodel:3-OXOACYL-ACP-REDUCT-RXN	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-OXOACYL-ACP-REDUCT-RXN RO:0002233 gomodel:CHEBI_57783_3-OXOACYL-ACP-REDUCT-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/38; endpoint types: /individuals/66/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-040_3747f075b742	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 RO:0002234 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003415."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/39; endpoint types: /individuals/74/type; /individuals/78/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-041_1533758efe06	gomodel:RXN3O-9780	RO:0002234	CHEBI:57379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9780 RO:0002234 gomodel:YeastPathways_FASYN-ELONG2-PWY/6690711d00001534."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/40; endpoint types: /individuals/19/type; /individuals/107/type""}, {""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9780 RO:0002234 gomodel:CHEBI_57379_RXN3O-9780."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/48; endpoint types: /individuals/19/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-042_f5acc0b4d29c	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428	RO:0002233	CHEBI:2393	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428 RO:0002233 gomodel:B-KETOACYL-ACP_3-OXOACYL-ACP-SYNTH-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/41; endpoint types: /individuals/90/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-043_ecc984f33de9	gomodel:3-OXOACYL-ACP-SYNTH-RXN	RO:0002413	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-OXOACYL-ACP-SYNTH-RXN RO:0002413 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/42; endpoint types: /individuals/67/type; /individuals/90/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-045_6f054a0e62f2	gomodel:ENOYL-ACP-REDUCT-NADPH-RXN	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ENOYL-ACP-REDUCT-NADPH-RXN RO:0002233 gomodel:CHEBI_57783_ENOYL-ACP-REDUCT-NADPH-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/44; endpoint types: /individuals/16/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-046_92dda8204dc4	SGD:S000001665	pathwaymech:enables	gomodel:ENOYL-ACP-REDUCT-NADPH-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ENOYL-ACP-REDUCT-NADPH-RXN RO:0002333 gomodel:YKL182W-MONOMER_ENOYL-ACP-REDUCT-NADPH-RXN_controller."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/45; endpoint types: /individuals/16/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-047_c4eeaf859107	gomodel:PALMITOYL-COA-HYDROLASE-RXN	RO:0002233	CHEBI:57379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:PALMITOYL-COA-HYDROLASE-RXN RO:0002233 gomodel:CHEBI_57379_RXN3O-9780."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/46; endpoint types: /individuals/18/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-048_e15c29365b20	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411	RO:0002233	CHEBI:16018	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 RO:0002233 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003413."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/47; endpoint types: /individuals/74/type; /individuals/76/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-049_460d161b68f4	gomodel:RXN3O-9780	RO:0002233	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9780 RO:0002233 gomodel:CHEBI_57287_RXN3O-9780."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/49; endpoint types: /individuals/19/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-050_f690fa6d0154	gomodel:RXN3O-9780	RO:0002233	CHEBI:5697	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9780 RO:0002233 gomodel:YeastPathways_FASYN-ELONG2-PWY/6690711d00001629."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/50; endpoint types: /individuals/19/type; /individuals/113/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-051_1c21ccc5f219	gomodel:RXN3O-9780	RO:0002413	gomodel:PALMITOYL-COA-HYDROLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9780 RO:0002413 gomodel:PALMITOYL-COA-HYDROLASE-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/51; endpoint types: /individuals/19/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-052_244149e5aa9a	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428 RO:0002234 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003431."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/52; endpoint types: /individuals/90/type; /individuals/93/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-053_0b4f4acbf2c4	gomodel:ENOYL-ACP-REDUCT-NADPH-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ENOYL-ACP-REDUCT-NADPH-RXN RO:0002233 gomodel:CHEBI_15378_ENOYL-ACP-REDUCT-NADPH-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/53; endpoint types: /individuals/16/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-054_673c87631030	SGD:S000006152	pathwaymech:enables	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 RO:0002333 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003417."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/54; endpoint types: /individuals/74/type; /individuals/79/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-055_00356dedef00	gomodel:ENOYL-ACP-REDUCT-NADPH-RXN	RO:0002234	CHEBI:16018	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ENOYL-ACP-REDUCT-NADPH-RXN RO:0002234 gomodel:YeastPathways_FASYN-ELONG2-PWY/6690711d00001631."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/55; endpoint types: /individuals/16/type; /individuals/115/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-056_c6a6f9481092	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428	RO:0002234	CHEBI:84648	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428 RO:0002234 gomodel:OH-ACYL-ACP_3-OXOACYL-ACP-REDUCT-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/56; endpoint types: /individuals/90/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-057_b1b31fe19cd4	gomodel:3-OXOACYL-ACP-SYNTH-RXN	RO:0002233	CHEBI:16018	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-OXOACYL-ACP-SYNTH-RXN RO:0002233 gomodel:YeastPathways_FASYN-ELONG2-PWY/6690711d00001614."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/57; endpoint types: /individuals/67/type; /individuals/109/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-058_b5c2cb5b3874	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411	RO:0002413	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 RO:0002413 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/58; endpoint types: /individuals/74/type; /individuals/90/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-059_493ff4724b7f	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428 RO:0002233 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003430."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/59; endpoint types: /individuals/90/type; /individuals/92/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-060_bbc71136a9dd	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411	BFO:0000050	GO:0030497	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003411 BFO:0000050 gomodel:YeastPathways_FASYN-ELONG2-PWY/YeastPathways_FASYN-ELONG2-PWY."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/60; endpoint types: /individuals/74/type; /individuals/68/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-061_c746c4d6b0f1	gomodel:3-OXOACYL-ACP-SYNTH-RXN	BFO:0000050	GO:0030497	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-OXOACYL-ACP-SYNTH-RXN BFO:0000050 gomodel:YeastPathways_FASYN-ELONG2-PWY/YeastPathways_FASYN-ELONG2-PWY."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/61; endpoint types: /individuals/67/type; /individuals/68/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-062_43c6a4e1d5e3	gomodel:ENOYL-ACP-REDUCT-NADPH-RXN	RO:0002233	CHEBI:16018	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ENOYL-ACP-REDUCT-NADPH-RXN RO:0002233 gomodel:TRANS-D2-ENOYL-ACP_3-HYDROXYDECANOYL-ACP-DEHYDR-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/62; endpoint types: /individuals/16/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-063_18dc2a1fa282	gomodel:3-OXOACYL-ACP-SYNTH-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-OXOACYL-ACP-SYNTH-RXN RO:0002234 gomodel:CHEBI_16526_3-OXOACYL-ACP-SYNTH-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/63; endpoint types: /individuals/67/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-064_477fe56e0224	gomodel:3-OXOACYL-ACP-REDUCT-RXN	RO:0002234	CHEBI:84648	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-OXOACYL-ACP-REDUCT-RXN RO:0002234 gomodel:OH-ACYL-ACP_3-OXOACYL-ACP-REDUCT-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/64; endpoint types: /individuals/66/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-065_1d790b887bc4	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428 RO:0002233 gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003429."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/65; endpoint types: /individuals/90/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-066_08cbb016b516	gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN	BFO:0000050	GO:0030497	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN BFO:0000050 gomodel:YeastPathways_FASYN-ELONG2-PWY/YeastPathways_FASYN-ELONG2-PWY."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/66; endpoint types: /individuals/65/type; /individuals/68/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-067_746781cc9fbe	SGD:S000001665	pathwaymech:enables	gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN RO:0002333 gomodel:YKL182W-MONOMER_3-HYDROXYDECANOYL-ACP-DEHYDR-RXN_controller."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/67; endpoint types: /individuals/65/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-068_6f720c000585	gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN	RO:0002413	gomodel:ENOYL-ACP-REDUCT-NADPH-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN RO:0002413 gomodel:ENOYL-ACP-REDUCT-NADPH-RXN."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/68; endpoint types: /individuals/65/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_edge-069_bf0577ff171e	SGD:S000003780	pathwaymech:enables	gomodel:PALMITOYL-COA-HYDROLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_FASYN-ELONG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_assertion"": ""The model asserts gomodel:PALMITOYL-COA-HYDROLASE-RXN RO:0002333 gomodel:YeastPathways_FASYN-ELONG2-PWY/67c10cc400000547."", ""source_locator"": ""./YeastPathways_FASYN-ELONG2-PWY.json#/facts/69; endpoint types: /individuals/18/type; /individuals/117/type""}]"	"[{""id"": ""gomodel:YeastPathways_FASYN-ELONG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_FASYN-ELONG2-PWY.json"", ""title"": ""SGD GO-CAM fatty acid elongation pathway FASYN-ELONG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_location-63bbf8dc67a8_acc1061cf2b4	SGD:S000001538	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P35731	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P35731"", ""source_assertion"": ""UniProtKB:P35731 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3494/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P35731"", ""source_assertion"": ""UniProtKB:P35731 has the exact SGD cross-reference SGD:S000001538."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3494/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P35731"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P35731 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_location-ba1599cacb33_9502385d81f0	SGD:S000000863	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39525	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:16823961)	"[{""reference_id"": ""UniProtKB:P39525"", ""source_assertion"": ""UniProtKB:P39525 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4662/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P39525"", ""source_assertion"": ""UniProtKB:P39525 has the exact SGD cross-reference SGD:S000000863."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4662/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P39525"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39525 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_location-3677ecc5d882_b3ceea896a56	SGD:S000003780	RO:0001025	GO:0005777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41903	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10092594)	"[{""reference_id"": ""UniProtKB:P41903"", ""source_assertion"": ""UniProtKB:P41903 annotates location Peroxisome (SL-0204)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1826/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P41903"", ""source_assertion"": ""UniProtKB:P41903 has the exact SGD cross-reference SGD:S000003780."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1826/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P41903"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41903 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_FASYN-ELONG2-PWY_location-4ecbcd26d07c_4e63816e82f0	gomodel:YeastPathways_FASYN-ELONG2-PWY/6a4c244800003428	BFO:0000066	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P35731	Activity compartment supported by an inspected functional annotation. ECO:0000250; ECO:0000269 (PubMed:9388293). Alternative isoenzymes may function elsewhere.	"[{""reference_id"": ""UniProtKB:P35731"", ""source_assertion"": ""UniProtKB:P35731 describes the corresponding catalytic function in the mitochondrion; this projection applies to the activity enabled by SGD:S000001538."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3494/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P35731"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P35731 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-001_cb8846aebb11	RHEA:26528	RO:0002413	RHEA:32712	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02207|gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:ENOYL-COA-HYDRAT-RXN RO:0002413 gomodel:OHACYL-COA-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/0; endpoint types: /individuals/20/type; /individuals/22/type""}, {""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 annotates (3R)-hydroxyacyl-CoA hydration/dehydration (RHEA:26526). FOX2 uses the R intermediate; the imported S assignment is corrected."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/1/reaction""}, {""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction""}]"	"[{""id"": ""UniProtKB:Q02207"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02207 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-002_5f0e11a781ba	gomodel:ACYLCOASYN-RXN	RO:0002233	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:ACYLCOASYN-RXN RO:0002233 gomodel:CHEBI_57287_ACYLCOASYN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/1; endpoint types: /individuals/0/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-003_058c3e3db1d2	RHEA:26528	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02207|gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:ENOYL-COA-HYDRAT-RXN RO:0002233 gomodel:CHEBI_15377_ENOYL-COA-HYDRAT-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/2; endpoint types: /individuals/20/type; /individuals/1/type""}, {""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 annotates (3R)-hydroxyacyl-CoA hydration/dehydration (RHEA:26526). FOX2 uses the R intermediate; the imported S assignment is corrected."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q02207"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02207 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-004_f9ce56115e9d	gomodel:KETOACYLCOATHIOL-RXN	RO:0002233	CHEBI:15489	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002233 gomodel:CHEBI_15489_OHACYL-COA-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/3; endpoint types: /individuals/21/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-005_0b6ef0603314	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852	BFO:0000050	GO:0019395	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852 BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/4; endpoint types: /individuals/143/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-006_511d6f17c306	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831	RO:0002233	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006832."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/5; endpoint types: /individuals/124/type; /individuals/125/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-007_6ff3db7d7e8f	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810	RO:0002413	gomodel:RXN-11026	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810 RO:0002413 gomodel:RXN-11026."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/6; endpoint types: /individuals/106/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-008_3e7edc02bca7	SGD:S000004860	pathwaymech:enables	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831 RO:0002333 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006839."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/7; endpoint types: /individuals/124/type; /individuals/130/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-009_1dfdb898ff3e	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852	RO:0002233	CHEBI:71627	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006854."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/8; endpoint types: /individuals/143/type; /individuals/145/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-011_0388e12b4b34	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831	RO:0002234	CHEBI:77332	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831 RO:0002234 gomodel:CHEBI_77332_ACYLCOASYN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/10; endpoint types: /individuals/124/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-012_07980e9f9cd2	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775	RO:0002234	CHEBI:50998	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006777."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/11; endpoint types: /individuals/76/type; /individuals/78/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-013_76f22df79a0c	gomodel:ACYLCOASYN-RXN	BFO:0000050	GO:0019395	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:ACYLCOASYN-RXN BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/12; endpoint types: /individuals/0/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-014_163d67340bdb	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810	RO:0002234	CHEBI:77332	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810 RO:0002234 gomodel:CHEBI_77332_ACYLCOASYN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/13; endpoint types: /individuals/106/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-015_a5beab62944b	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006857."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/14; endpoint types: /individuals/143/type; /individuals/148/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-016_72fdebde7949	gomodel:KETOACYLCOATHIOL-RXN	RO:0002413	gomodel:ACYLCOASYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002413 gomodel:ACYLCOASYN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/15; endpoint types: /individuals/21/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-017_2ce444dacc6b	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787	RO:0002233	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006788."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/16; endpoint types: /individuals/87/type; /individuals/88/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-018_40a5cb6c562a	gomodel:KETOACYLCOATHIOL-RXN	RO:0002234	CHEBI:77332	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002234 gomodel:CHEBI_77332_KETOACYLCOATHIOL-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/17; endpoint types: /individuals/21/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-019_b8adfa377e2b	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787	RO:0002234	CHEBI:77332	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 RO:0002234 gomodel:CHEBI_77332_ACYLCOASYN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/18; endpoint types: /individuals/87/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-020_afbbd743d380	gomodel:RXN-11026	RO:0002234	CHEBI:16240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-11026 RO:0002234 gomodel:CHEBI_16240_RXN-11026."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/19; endpoint types: /individuals/23/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-021_5dbf0a5646e5	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775	BFO:0000050	GO:0019395	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775 BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/20; endpoint types: /individuals/76/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-022_3476874fb8a2	SGD:S000001717	pathwaymech:enables	RHEA:26528	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02207|gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:ENOYL-COA-HYDRAT-RXN RO:0002333 gomodel:YKR009C-MONOMER_ENOYL-COA-HYDRAT-RXN_controller."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/21; endpoint types: /individuals/20/type; /individuals/26/type""}, {""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 annotates (3R)-hydroxyacyl-CoA hydration/dehydration (RHEA:26526). FOX2 uses the R intermediate; the imported S assignment is corrected."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q02207"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02207 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-023_6d09b47894e2	RHEA:45241	RO:0002233	CHEBI:85110	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q08558		"[{""reference_id"": ""UniProtKB:Q08558"", ""source_assertion"": ""UniProtKB:Q08558 annotates (3E,5Z)-dienoyl-CoA to (2E,4E)-dienoyl-CoA isomerization (RHEA:45240); DCI1 is distinct from the retained ECI1 monoene isomerase activity."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2894/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q08558"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q08558 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-024_0ea7fbae4edf	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006791."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/23; endpoint types: /individuals/87/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-025_8dc7bb811021	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006813."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/24; endpoint types: /individuals/106/type; /individuals/109/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-028_27696ae6a198	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831	BFO:0000050	GO:0019395	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831 BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/27; endpoint types: /individuals/124/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-029_28a9faad385c	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006855."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/28; endpoint types: /individuals/143/type; /individuals/146/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-030_1404570957f7	RHEA:26528	RO:0002233	CHEBI:50998	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02207|gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:ENOYL-COA-HYDRAT-RXN RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6690711d00000514."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/29; endpoint types: /individuals/20/type; /individuals/164/type""}, {""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 annotates (3R)-hydroxyacyl-CoA hydration/dehydration (RHEA:26526). FOX2 uses the R intermediate; the imported S assignment is corrected."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q02207"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02207 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-032_2a60c6a7de5a	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006834."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/31; endpoint types: /individuals/124/type; /individuals/127/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-033_f4190daacf2b	gomodel:KETOACYLCOATHIOL-RXN	BFO:0000050	GO:0019395	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:KETOACYLCOATHIOL-RXN BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/32; endpoint types: /individuals/21/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-034_3390e5b9ba5e	RHEA:26528	RO:0002234	CHEBI:57319	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02207		"[{""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 annotates (3R)-hydroxyacyl-CoA hydration/dehydration (RHEA:26526). FOX2 uses the R intermediate; the imported S assignment is corrected."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q02207"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02207 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-035_3d0ef7b6fe71	SGD:S000004274	pathwaymech:enables	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775 RO:0002333 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006779."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/34; endpoint types: /individuals/76/type; /individuals/79/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-036_7879662bf0be	gomodel:ACYLCOASYN-RXN	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:ACYLCOASYN-RXN RO:0002234 gomodel:CHEBI_456215_ACYLCOASYN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/35; endpoint types: /individuals/0/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-037_f1dfd75fb0ea	gomodel:RXN-11026	BFO:0000050	GO:0019395	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-11026 BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/36; endpoint types: /individuals/23/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-038_a4655c9ab399	SGD:S000005844	pathwaymech:enables	gomodel:ACYLCOASYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:ACYLCOASYN-RXN RO:0002333 gomodel:YOR317W-MONOMER_ACYLCOASYN-RXN_controller."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/37; endpoint types: /individuals/0/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-039_3132886034af	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852	RO:0002233	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006853."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/38; endpoint types: /individuals/143/type; /individuals/144/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-040_e99460211d3d	RHEA:32712	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02207|gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:OHACYL-COA-DEHYDROG-RXN RO:0002234 gomodel:CHEBI_15378_OHACYL-COA-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/39; endpoint types: /individuals/22/type; /individuals/2/type""}, {""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction""}]"	"[{""id"": ""UniProtKB:Q02207"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02207 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-041_abd8aefb5aef	gomodel:ACYLCOASYN-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:ACYLCOASYN-RXN RO:0002234 gomodel:CHEBI_29888_ACYLCOASYN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/40; endpoint types: /individuals/0/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-042_9a4dd4fc93c2	RHEA:45241	BFO:0000050	GO:0019395	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q08558|gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:ENOYL-COA-DELTA-ISOM-RXN BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/41; endpoint types: /individuals/19/type; /individuals/69/type""}, {""reference_id"": ""UniProtKB:Q08558"", ""source_assertion"": ""UniProtKB:Q08558 annotates (3E,5Z)-dienoyl-CoA to (2E,4E)-dienoyl-CoA isomerization (RHEA:45240); DCI1 is distinct from the retained ECI1 monoene isomerase activity."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2894/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q08558"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q08558 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-043_574c4d3e3330	gomodel:RXN-11026	RO:0002413	RHEA:26528	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02207|gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-11026 RO:0002413 gomodel:ENOYL-COA-HYDRAT-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/42; endpoint types: /individuals/23/type; /individuals/20/type""}, {""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 annotates (3R)-hydroxyacyl-CoA hydration/dehydration (RHEA:26526). FOX2 uses the R intermediate; the imported S assignment is corrected."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q02207"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02207 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-045_7025639baef2	gomodel:RXN-11026	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-11026 RO:0002233 gomodel:CHEBI_15379_RXN-11026."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/44; endpoint types: /individuals/23/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-046_d6710995512b	RHEA:32712	RO:0002234	CHEBI:15489	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02207|gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:OHACYL-COA-DEHYDROG-RXN RO:0002234 gomodel:CHEBI_15489_OHACYL-COA-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/45; endpoint types: /individuals/22/type; /individuals/5/type""}, {""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction""}]"	"[{""id"": ""UniProtKB:Q02207"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02207 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-047_ddcf39e590ba	gomodel:ACYLCOASYN-RXN	RO:0002233	CHEBI:71627	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:ACYLCOASYN-RXN RO:0002233 gomodel:CHEBI_71627_ACYLCOASYN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/46; endpoint types: /individuals/0/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-048_d25e6d79993a	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852	RO:0002413	gomodel:RXN-11026	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852 RO:0002413 gomodel:RXN-11026."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/47; endpoint types: /individuals/143/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-049_56615e659013	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810	RO:0002233	CHEBI:71627	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006812."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/48; endpoint types: /individuals/106/type; /individuals/108/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-050_f54e0a23ced3	SGD:S000001422	pathwaymech:enables	gomodel:KETOACYLCOATHIOL-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002333 gomodel:YIL160C-MONOMER_KETOACYLCOATHIOL-RXN_controller."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/49; endpoint types: /individuals/21/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-051_fe7fcc4ef666	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006790."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/50; endpoint types: /individuals/87/type; /individuals/90/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-052_846954458bf9	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787	RO:0002233	CHEBI:71627	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006789."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/51; endpoint types: /individuals/87/type; /individuals/89/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-053_c8dcaf4b4294	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810	RO:0002233	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006811."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/52; endpoint types: /individuals/106/type; /individuals/107/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-054_7d97aa84597f	gomodel:KETOACYLCOATHIOL-RXN	RO:0002413	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002413 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/53; endpoint types: /individuals/21/type; /individuals/124/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-055_5d9c02c0ca2e	SGD:S000001717	pathwaymech:enables	RHEA:32712	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02207|gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:OHACYL-COA-DEHYDROG-RXN RO:0002333 gomodel:YKR009C-MONOMER_OHACYL-COA-DEHYDROG-RXN_controller."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/54; endpoint types: /individuals/22/type; /individuals/27/type""}, {""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction""}]"	"[{""id"": ""UniProtKB:Q02207"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02207 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-056_b96768238c32	gomodel:KETOACYLCOATHIOL-RXN	RO:0002413	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002413 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/55; endpoint types: /individuals/21/type; /individuals/87/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-057_880969c312a3	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787	RO:0002413	gomodel:RXN-11026	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 RO:0002413 gomodel:RXN-11026."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/56; endpoint types: /individuals/87/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-058_39af71ff179c	SGD:S000000245	pathwaymech:enables	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852 RO:0002333 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006858."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/57; endpoint types: /individuals/143/type; /individuals/149/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-059_03ff49ef0f04	gomodel:RXN-11026	RO:0002233	CHEBI:77332	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-11026 RO:0002233 gomodel:CHEBI_77332_ACYLCOASYN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/58; endpoint types: /individuals/23/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-060_21acf0ad96bb	SGD:S000003173	pathwaymech:enables	gomodel:RXN-11026	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-11026 RO:0002333 gomodel:YGL205W-MONOMER_RXN-11026_controller."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/59; endpoint types: /individuals/23/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-061_b15deb5479b6	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006836."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/60; endpoint types: /individuals/124/type; /individuals/129/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-062_dae961ef40f8	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006792."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/61; endpoint types: /individuals/87/type; /individuals/92/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-063_d48ecda243d7	gomodel:ACYLCOASYN-RXN	RO:0002413	gomodel:RXN-11026	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:ACYLCOASYN-RXN RO:0002413 gomodel:RXN-11026."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/62; endpoint types: /individuals/0/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-065_a2829a2258ae	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831	RO:0002413	gomodel:RXN-11026	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831 RO:0002413 gomodel:RXN-11026."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/64; endpoint types: /individuals/124/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-066_143b6fc5252f	RHEA:26528	BFO:0000050	GO:0019395	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02207|gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:ENOYL-COA-HYDRAT-RXN BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/65; endpoint types: /individuals/20/type; /individuals/69/type""}, {""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 annotates (3R)-hydroxyacyl-CoA hydration/dehydration (RHEA:26526). FOX2 uses the R intermediate; the imported S assignment is corrected."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q02207"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02207 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-067_33268114af54	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006856."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/66; endpoint types: /individuals/143/type; /individuals/147/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-068_30056c6d02cc	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775	RO:0002413	RHEA:32712	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02207|gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775 RO:0002413 gomodel:OHACYL-COA-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/67; endpoint types: /individuals/76/type; /individuals/22/type""}, {""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction""}]"	"[{""id"": ""UniProtKB:Q02207"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02207 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-070_71dbcc34026d	gomodel:KETOACYLCOATHIOL-RXN	RO:0002233	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002233 gomodel:CHEBI_57287_KETOACYLCOATHIOL-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/69; endpoint types: /individuals/21/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-071_927fd5cd2f1a	SGD:S000005706	pathwaymech:enables	RHEA:45241	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q08558|gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:ENOYL-COA-DELTA-ISOM-RXN RO:0002333 gomodel:YOR180C-MONOMER_ENOYL-COA-DELTA-ISOM-RXN_controller."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/70; endpoint types: /individuals/19/type; /individuals/28/type""}, {""reference_id"": ""UniProtKB:Q08558"", ""source_assertion"": ""UniProtKB:Q08558 annotates (3E,5Z)-dienoyl-CoA to (2E,4E)-dienoyl-CoA isomerization (RHEA:45240); DCI1 is distinct from the retained ECI1 monoene isomerase activity."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2894/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q08558"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q08558 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-072_9fae8073326e	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006815."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/71; endpoint types: /individuals/106/type; /individuals/111/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-073_30fa446d70f8	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006835."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/72; endpoint types: /individuals/124/type; /individuals/128/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-076_7d881e0fc2c5	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006814."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/75; endpoint types: /individuals/106/type; /individuals/110/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-077_cd822bbe7c0c	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810	BFO:0000050	GO:0019395	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810 BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/76; endpoint types: /individuals/106/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-078_789736c3912e	gomodel:RXN-11026	RO:0002234	CHEBI:50998	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-11026 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6690711d00000512."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/77; endpoint types: /individuals/23/type; /individuals/162/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-079_f81f86d45b0a	RHEA:32712	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02207|gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:OHACYL-COA-DEHYDROG-RXN RO:0002233 gomodel:CHEBI_57540_OHACYL-COA-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/78; endpoint types: /individuals/22/type; /individuals/14/type""}, {""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction""}]"	"[{""id"": ""UniProtKB:Q02207"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02207 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-080_71388a324949	gomodel:KETOACYLCOATHIOL-RXN	RO:0002234	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002234 gomodel:CHEBI_57288_KETOACYLCOATHIOL-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/79; endpoint types: /individuals/21/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-081_3f598cd0391b	RHEA:32712	BFO:0000050	GO:0019395	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02207|gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:OHACYL-COA-DEHYDROG-RXN BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/80; endpoint types: /individuals/22/type; /individuals/69/type""}, {""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction""}]"	"[{""id"": ""UniProtKB:Q02207"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02207 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-082_99f848cc2d96	gomodel:KETOACYLCOATHIOL-RXN	RO:0002413	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002413 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/81; endpoint types: /individuals/21/type; /individuals/143/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-083_735f65d975b5	RHEA:32712	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02207|gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:OHACYL-COA-DEHYDROG-RXN RO:0002234 gomodel:CHEBI_57945_OHACYL-COA-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/82; endpoint types: /individuals/22/type; /individuals/15/type""}, {""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction""}]"	"[{""id"": ""UniProtKB:Q02207"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02207 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-084_94330ef91640	RHEA:32712	RO:0002233	CHEBI:57319	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02207		"[{""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction""}]"	"[{""id"": ""UniProtKB:Q02207"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02207 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-085_aae1ca65d367	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 BFO:0000066 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006798."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/84; endpoint types: /individuals/87/type; /individuals/94/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-086_2166e0fc44a5	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775	RO:0002233	CHEBI:27773	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006776."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/85; endpoint types: /individuals/76/type; /individuals/77/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-087_2c9055953aae	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831	RO:0002233	CHEBI:71627	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006833."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/86; endpoint types: /individuals/124/type; /individuals/126/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-088_d7af6e16a2f3	gomodel:KETOACYLCOATHIOL-RXN	RO:0002413	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002413 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/87; endpoint types: /individuals/21/type; /individuals/106/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-089_3c8f361a66e9	gomodel:ACYLCOASYN-RXN	RO:0002234	CHEBI:77332	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:ACYLCOASYN-RXN RO:0002234 gomodel:CHEBI_77332_ACYLCOASYN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/88; endpoint types: /individuals/0/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-091_ddbc13f8042e	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787	BFO:0000050	GO:0019395	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/90; endpoint types: /individuals/87/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-092_c1149ef32007	SGD:S000000817	pathwaymech:enables	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 RO:0002333 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006795."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/91; endpoint types: /individuals/87/type; /individuals/93/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-093_62e715bbe1a9	SGD:S000001271	pathwaymech:enables	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810 RO:0002333 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006816."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/92; endpoint types: /individuals/106/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-094_3d8ba3a3747c	RHEA:45241	RO:0002234	CHEBI:85111	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q08558		"[{""reference_id"": ""UniProtKB:Q08558"", ""source_assertion"": ""UniProtKB:Q08558 annotates (3E,5Z)-dienoyl-CoA to (2E,4E)-dienoyl-CoA isomerization (RHEA:45240); DCI1 is distinct from the retained ECI1 monoene isomerase activity."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2894/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q08558"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q08558 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-095_dd6e650ac2ef	RHEA:32712	RO:0002413	gomodel:KETOACYLCOATHIOL-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02207|gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:OHACYL-COA-DEHYDROG-RXN RO:0002413 gomodel:KETOACYLCOATHIOL-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/94; endpoint types: /individuals/22/type; /individuals/21/type""}, {""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction""}]"	"[{""id"": ""UniProtKB:Q02207"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02207 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-096_879243a28a8d	gomodel:ACYLCOASYN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:ACYLCOASYN-RXN RO:0002233 gomodel:CHEBI_30616_ACYLCOASYN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/95; endpoint types: /individuals/0/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_edge-097_b696c12abc32	gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852	RO:0002234	CHEBI:77332	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-FAO-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852 RO:0002234 gomodel:CHEBI_77332_ACYLCOASYN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-FAO-PWY.json#/facts/96; endpoint types: /individuals/143/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-FAO-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json"", ""title"": ""SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_location-c1ff8530d012_001ddba440e4	SGD:S000004860	RO:0001025	GO:0005811	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47912	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:21820081); ECO:0000269 (PubMed:24868093)	"[{""reference_id"": ""UniProtKB:P47912"", ""source_assertion"": ""UniProtKB:P47912 annotates location Lipid droplet (SL-0154)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1993/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P47912"", ""source_assertion"": ""UniProtKB:P47912 has the exact SGD cross-reference SGD:S000004860."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1993/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P47912"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47912 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_location-864a72dd4309_4d3d8fbfe450	SGD:S000001717	RO:0001025	GO:0005777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02207	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 annotates location Peroxisome (SL-0204)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2412/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q02207"", ""source_assertion"": ""UniProtKB:Q02207 has the exact SGD cross-reference SGD:S000001717."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2412/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q02207"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02207 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_location-8ab225a58881_b9840a1c074a	SGD:S000004274	RO:0001025	GO:0005777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q05871	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10381339); ECO:0000269 (PubMed:11302517); ECO:0000269 (PubMed:9837886) Source qualification: This location is DCI1 dependent	"[{""reference_id"": ""UniProtKB:Q05871"", ""source_assertion"": ""UniProtKB:Q05871 annotates location Peroxisome (SL-0204)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2689/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q05871"", ""source_assertion"": ""UniProtKB:Q05871 has the exact SGD cross-reference SGD:S000004274."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2689/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q05871"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q05871 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_location-0ad37f893d09_ff2c5de8a7cf	SGD:S000005844	RO:0001025	GO:0005811	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P30624	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10515935); ECO:0000269 (PubMed:21820081); ECO:0000269 (PubMed:24868093)	"[{""reference_id"": ""UniProtKB:P30624"", ""source_assertion"": ""UniProtKB:P30624 annotates location Lipid droplet (SL-0154)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/826/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P30624"", ""source_assertion"": ""UniProtKB:P30624 has the exact SGD cross-reference SGD:S000005844."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/826/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P30624"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P30624 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_location-0cf3053de91e_7fbb24dd6e9d	SGD:S000005844	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P30624	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:27136724)	"[{""reference_id"": ""UniProtKB:P30624"", ""source_assertion"": ""UniProtKB:P30624 annotates location Cell membrane (SL-0039)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/826/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P30624"", ""source_assertion"": ""UniProtKB:P30624 has the exact SGD cross-reference SGD:S000005844."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/826/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P30624"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P30624 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_location-dcc26d0a11b4_9b1bc01c5935	SGD:S000001422	RO:0001025	GO:0005777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P27796	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:7754706); ECO:0000269 (PubMed:8125978)	"[{""reference_id"": ""UniProtKB:P27796"", ""source_assertion"": ""UniProtKB:P27796 annotates location Peroxisome (SL-0204)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/771/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P27796"", ""source_assertion"": ""UniProtKB:P27796 has the exact SGD cross-reference SGD:S000001422."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/771/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P27796"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P27796 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_location-9109d901855b_3cd3803d9569	SGD:S000001422	RO:0001025	GO:0005758	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P27796	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:22984289)	"[{""reference_id"": ""UniProtKB:P27796"", ""source_assertion"": ""UniProtKB:P27796 annotates location Mitochondrion intermembrane space (SL-0169)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/771/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P27796"", ""source_assertion"": ""UniProtKB:P27796 has the exact SGD cross-reference SGD:S000001422."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/771/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P27796"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P27796 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_location-01d3482e3b5c_b259e9aa87b2	SGD:S000000245	RO:0001025	GO:0005811	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38225	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10515935); ECO:0000269 (PubMed:21820081); ECO:0000269 (PubMed:24868093)	"[{""reference_id"": ""UniProtKB:P38225"", ""source_assertion"": ""UniProtKB:P38225 annotates location Lipid droplet (SL-0154)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1321/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38225"", ""source_assertion"": ""UniProtKB:P38225 has the exact SGD cross-reference SGD:S000000245."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1321/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38225"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38225 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_location-bf87d74d7373_fbc5e7a824c4	SGD:S000000245	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38225	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:17679730) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P38225"", ""source_assertion"": ""UniProtKB:P38225 annotates location Cell membrane (SL-0039)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1321/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38225"", ""source_assertion"": ""UniProtKB:P38225 has the exact SGD cross-reference SGD:S000000245."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1321/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38225"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38225 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_location-1856dbd55a58_14f1c800f1fd	SGD:S000000245	RO:0001025	GO:0005778	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38225	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:22493507) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P38225"", ""source_assertion"": ""UniProtKB:P38225 annotates location Peroxisome membrane (SL-0203)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1321/comments/1/subcellularLocations/2; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38225"", ""source_assertion"": ""UniProtKB:P38225 has the exact SGD cross-reference SGD:S000000245."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1321/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38225"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38225 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_location-6a5aed4f4be6_37ae3beb803a	SGD:S000000245	RO:0001025	GO:0005777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38225	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11330068)	"[{""reference_id"": ""UniProtKB:P38225"", ""source_assertion"": ""UniProtKB:P38225 annotates location Peroxisome (SL-0204)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1321/comments/1/subcellularLocations/3; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38225"", ""source_assertion"": ""UniProtKB:P38225 has the exact SGD cross-reference SGD:S000000245."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1321/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38225"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38225 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_location-06b883bcfcba_e3be61bbc50b	SGD:S000003173	RO:0001025	GO:0005777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P13711	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P13711"", ""source_assertion"": ""UniProtKB:P13711 annotates location Peroxisome (SL-0204)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3301/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P13711"", ""source_assertion"": ""UniProtKB:P13711 has the exact SGD cross-reference SGD:S000003173."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3301/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P13711"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P13711 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_location-8759024aa2e2_fce5252164ec	SGD:S000005706	RO:0001025	GO:0005777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q08558	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10381339); ECO:0000269 (PubMed:10455114); ECO:0000269 (PubMed:10639339)	"[{""reference_id"": ""UniProtKB:Q08558"", ""source_assertion"": ""UniProtKB:Q08558 annotates location Peroxisome (SL-0204)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2894/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q08558"", ""source_assertion"": ""UniProtKB:Q08558 has the exact SGD cross-reference SGD:S000005706."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2894/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q08558"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q08558 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_location-4003c6b00594_47f79438f119	SGD:S000000817	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39518	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:7988550) Source qualification: Imported via the peroxisome targeting signal type 1 (PTS1)-dependent protein import pathway	"[{""reference_id"": ""UniProtKB:P39518"", ""source_assertion"": ""UniProtKB:P39518 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1562/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P39518"", ""source_assertion"": ""UniProtKB:P39518 has the exact SGD cross-reference SGD:S000000817."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1562/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P39518"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39518 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_location-2789b76c17e0_5be952d4763b	SGD:S000000817	RO:0001025	GO:0005778	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39518	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:8670886) Topology: Peripheral membrane protein. Orientation: Matrix side. Source qualification: Imported via the peroxisome targeting signal type 1 (PTS1)-dependent protein import pathway	"[{""reference_id"": ""UniProtKB:P39518"", ""source_assertion"": ""UniProtKB:P39518 annotates location Peroxisome membrane (SL-0203)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1562/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P39518"", ""source_assertion"": ""UniProtKB:P39518 has the exact SGD cross-reference SGD:S000000817."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1562/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P39518"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39518 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_location-90f63b049111_cdb7e17d61a5	SGD:S000001271	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39002	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P39002"", ""source_assertion"": ""UniProtKB:P39002 annotates location Cell membrane (SL-0039)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1536/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P39002"", ""source_assertion"": ""UniProtKB:P39002 has the exact SGD cross-reference SGD:S000001271."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1536/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P39002"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39002 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_location-4f95e3dcaff5_a988dd4561ae	RHEA:45241	BFO:0000066	GO:0005777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q08558	Activity compartment supported by an inspected functional annotation. ECO:0000269 (PubMed:10381339); ECO:0000269 (PubMed:10455114); ECO:0000269 (PubMed:11302517). Alternative isoenzymes may function elsewhere.	"[{""reference_id"": ""UniProtKB:Q08558"", ""source_assertion"": ""UniProtKB:Q08558 describes the corresponding catalytic function in the peroxisome; this projection applies to the activity enabled by SGD:S000005706."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2894/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q08558"", ""source_assertion"": ""UniProtKB:Q08558 annotates (3E,5Z)-dienoyl-CoA to (2E,4E)-dienoyl-CoA isomerization (RHEA:45240); DCI1 is distinct from the retained ECI1 monoene isomerase activity."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2894/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q08558"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q08558 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_cofactor-431fc1426ab4_a9ce44e75abe	SGD:S000004860	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47912	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P47912"", ""source_assertion"": ""UniProtKB:P47912 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1993/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P47912"", ""source_assertion"": ""UniProtKB:P47912 has the exact SGD cross-reference SGD:S000004860."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1993/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P47912"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47912 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_cofactor-7fe5b5c471d5_52694ac6b925	SGD:S000005844	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P30624	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:8206942)	"[{""reference_id"": ""UniProtKB:P30624"", ""source_assertion"": ""UniProtKB:P30624 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/826/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P30624"", ""source_assertion"": ""UniProtKB:P30624 has the exact SGD cross-reference SGD:S000005844."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/826/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P30624"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P30624 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_cofactor-6bde46647e20_21271696d875	SGD:S000003173	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P13711	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P13711"", ""source_assertion"": ""UniProtKB:P13711 annotates CHEBI:57692 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3301/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P13711"", ""source_assertion"": ""UniProtKB:P13711 has the exact SGD cross-reference SGD:S000003173."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3301/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P13711"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P13711 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_cofactor-6626d61a19de_6fe12c4b1052	SGD:S000000817	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39518	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P30624)	"[{""reference_id"": ""UniProtKB:P39518"", ""source_assertion"": ""UniProtKB:P39518 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1562/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P39518"", ""source_assertion"": ""UniProtKB:P39518 has the exact SGD cross-reference SGD:S000000817."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1562/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P39518"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39518 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-FAO-PWY_cofactor-22a5602ee0a1_12e0723fbd75	SGD:S000001271	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39002	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P30624)	"[{""reference_id"": ""UniProtKB:P39002"", ""source_assertion"": ""UniProtKB:P39002 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1536/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P39002"", ""source_assertion"": ""UniProtKB:P39002 has the exact SGD cross-reference SGD:S000001271."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1536/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P39002"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39002 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-001_0bedabe87db0	CHEBI:15377	pathwaymech:consumes	RHEA:23705	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23705		"[{""reference_id"": ""RHEA:23705"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:23705 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23705']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23705"", ""source_version"": ""139"", ""title"": ""Rhea 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23705""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-002_209c27588828	CHEBI:37565	pathwaymech:consumes	RHEA:23705	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23705		"[{""reference_id"": ""RHEA:23705"", ""source_assertion"": ""Rhea lists CHEBI:37565 on the substrates side of RHEA:23705 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23705']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23705"", ""source_version"": ""139"", ""title"": ""Rhea 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23705""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-003_6c93c65e48b1	RHEA:23705	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23705		"[{""reference_id"": ""RHEA:23705"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:23705 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23705']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23705"", ""source_version"": ""139"", ""title"": ""Rhea 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23705""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-004_4b9c79af4ab8	RHEA:23705	pathwaymech:produces	CHEBI:15740	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23705		"[{""reference_id"": ""RHEA:23705"", ""source_assertion"": ""Rhea lists CHEBI:15740 on the products side of RHEA:23705 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23705']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23705"", ""source_version"": ""139"", ""title"": ""Rhea 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23705""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-005_fb5b1c896e00	RHEA:23705	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23705		"[{""reference_id"": ""RHEA:23705"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:23705 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23705']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23705"", ""source_version"": ""139"", ""title"": ""Rhea 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23705""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-006_c30f8f517bab	RHEA:23705	pathwaymech:produces	CHEBI:58614	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23705		"[{""reference_id"": ""RHEA:23705"", ""source_assertion"": ""Rhea lists CHEBI:58614 on the products side of RHEA:23705 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23705']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23705"", ""source_version"": ""139"", ""title"": ""Rhea 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23705""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-007_79434206f4d3	CHEBI:15377	pathwaymech:consumes	RHEA:21869	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21869		"[{""reference_id"": ""RHEA:21869"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:21869 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21869']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21869"", ""source_version"": ""139"", ""title"": ""Rhea 5-amino-6-(5-phospho-D-ribosylamino)uracil-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21869""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-008_486c72956f38	CHEBI:15378	pathwaymech:consumes	RHEA:21869	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21869		"[{""reference_id"": ""RHEA:21869"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:21869 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21869']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21869"", ""source_version"": ""139"", ""title"": ""Rhea 5-amino-6-(5-phospho-D-ribosylamino)uracil-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21869""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-009_c5a8a2048d79	CHEBI:58614	pathwaymech:consumes	RHEA:21869	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21869		"[{""reference_id"": ""RHEA:21869"", ""source_assertion"": ""Rhea lists CHEBI:58614 on the substrates side of RHEA:21869 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21869']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21869"", ""source_version"": ""139"", ""title"": ""Rhea 5-amino-6-(5-phospho-D-ribosylamino)uracil-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21869""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-010_3c8dc18a1d2f	RHEA:21869	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21869		"[{""reference_id"": ""RHEA:21869"", ""source_assertion"": ""Rhea lists CHEBI:28938 on the products side of RHEA:21869 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21869']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21869"", ""source_version"": ""139"", ""title"": ""Rhea 5-amino-6-(5-phospho-D-ribosylamino)uracil-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21869""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-011_f89d430c47dd	RHEA:21869	pathwaymech:produces	CHEBI:58453	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21869		"[{""reference_id"": ""RHEA:21869"", ""source_assertion"": ""Rhea lists CHEBI:58453 on the products side of RHEA:21869 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21869']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21869"", ""source_version"": ""139"", ""title"": ""Rhea 5-amino-6-(5-phospho-D-ribosylamino)uracil-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21869""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-012_53662e4aedc9	CHEBI:15378	pathwaymech:consumes	RHEA:17847	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17847		"[{""reference_id"": ""RHEA:17847"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:17847 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17847']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17847"", ""source_version"": ""139"", ""title"": ""Rhea 5-amino-6-(5-phospho-D-ribitylamino)uracil-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17847""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-013_1ec8e71b8f43	CHEBI:57783	pathwaymech:consumes	RHEA:17847	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17847		"[{""reference_id"": ""RHEA:17847"", ""source_assertion"": ""Rhea lists CHEBI:57783 on the substrates side of RHEA:17847 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17847']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17847"", ""source_version"": ""139"", ""title"": ""Rhea 5-amino-6-(5-phospho-D-ribitylamino)uracil-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17847""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-014_98744f465d11	CHEBI:58453	pathwaymech:consumes	RHEA:17847	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17847		"[{""reference_id"": ""RHEA:17847"", ""source_assertion"": ""Rhea lists CHEBI:58453 on the substrates side of RHEA:17847 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17847']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17847"", ""source_version"": ""139"", ""title"": ""Rhea 5-amino-6-(5-phospho-D-ribitylamino)uracil-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17847""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-015_864ab021d449	RHEA:17847	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17847		"[{""reference_id"": ""RHEA:17847"", ""source_assertion"": ""Rhea lists CHEBI:58349 on the products side of RHEA:17847 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17847']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17847"", ""source_version"": ""139"", ""title"": ""Rhea 5-amino-6-(5-phospho-D-ribitylamino)uracil-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17847""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-016_38a10391eda6	RHEA:17847	pathwaymech:produces	CHEBI:58421	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17847		"[{""reference_id"": ""RHEA:17847"", ""source_assertion"": ""Rhea lists CHEBI:58421 on the products side of RHEA:17847 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17847']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17847"", ""source_version"": ""139"", ""title"": ""Rhea 5-amino-6-(5-phospho-D-ribitylamino)uracil-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17847""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-017_1d7ce83306c1	CHEBI:58121	pathwaymech:consumes	RHEA:18458	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18458		"[{""reference_id"": ""RHEA:18458"", ""source_assertion"": ""Rhea lists CHEBI:58121 on the substrates side of RHEA:18458 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18458']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18458"", ""source_version"": ""139"", ""title"": ""Rhea (2S)-2-hydroxy-3-oxobutyl phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18458""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-018_17aa4159f671	RHEA:18458	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18458		"[{""reference_id"": ""RHEA:18458"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:18458 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18458']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18458"", ""source_version"": ""139"", ""title"": ""Rhea (2S)-2-hydroxy-3-oxobutyl phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18458""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-019_e4cf5f938b92	RHEA:18458	pathwaymech:produces	CHEBI:15740	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18458		"[{""reference_id"": ""RHEA:18458"", ""source_assertion"": ""Rhea lists CHEBI:15740 on the products side of RHEA:18458 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18458']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18458"", ""source_version"": ""139"", ""title"": ""Rhea (2S)-2-hydroxy-3-oxobutyl phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18458""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-020_679b92496044	RHEA:18458	pathwaymech:produces	CHEBI:58830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18458		"[{""reference_id"": ""RHEA:18458"", ""source_assertion"": ""Rhea lists CHEBI:58830 on the products side of RHEA:18458 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18458']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18458"", ""source_version"": ""139"", ""title"": ""Rhea (2S)-2-hydroxy-3-oxobutyl phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18458""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-021_8b8faec79d3c	CHEBI:15377	pathwaymech:consumes	RHEA:25198	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25198		"[{""reference_id"": ""RHEA:25198"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:25198 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25198']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25198"", ""source_version"": ""139"", ""title"": ""Rhea 5-amino-6-(D-ribitylamino)uracil-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25198""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-022_b0303100691d	CHEBI:58421	pathwaymech:consumes	RHEA:25198	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25198		"[{""reference_id"": ""RHEA:25198"", ""source_assertion"": ""Rhea lists CHEBI:58421 on the substrates side of RHEA:25198 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25198']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25198"", ""source_version"": ""139"", ""title"": ""Rhea 5-amino-6-(D-ribitylamino)uracil-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25198""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-023_879514fbff75	RHEA:25198	pathwaymech:produces	CHEBI:15934	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25198		"[{""reference_id"": ""RHEA:25198"", ""source_assertion"": ""Rhea lists CHEBI:15934 on the products side of RHEA:25198 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25198']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25198"", ""source_version"": ""139"", ""title"": ""Rhea 5-amino-6-(D-ribitylamino)uracil-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25198""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-024_405d34a36942	RHEA:25198	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25198		"[{""reference_id"": ""RHEA:25198"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:25198 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25198']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25198"", ""source_version"": ""139"", ""title"": ""Rhea 5-amino-6-(D-ribitylamino)uracil-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25198""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-025_4a7d7170a365	CHEBI:15934	pathwaymech:consumes	RHEA:26153	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26153		"[{""reference_id"": ""RHEA:26153"", ""source_assertion"": ""Rhea lists CHEBI:15934 on the substrates side of RHEA:26153 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/26153']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:26153"", ""source_version"": ""139"", ""title"": ""Rhea 6,7-dimethyl-8-(1-D-ribityl)lumazine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/26153""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-026_edeed8fd1439	CHEBI:58830	pathwaymech:consumes	RHEA:26153	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26153		"[{""reference_id"": ""RHEA:26153"", ""source_assertion"": ""Rhea lists CHEBI:58830 on the substrates side of RHEA:26153 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/26153']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:26153"", ""source_version"": ""139"", ""title"": ""Rhea 6,7-dimethyl-8-(1-D-ribityl)lumazine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/26153""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-027_e4e92087e164	RHEA:26153	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26153		"[{""reference_id"": ""RHEA:26153"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:26153 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/26153']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:26153"", ""source_version"": ""139"", ""title"": ""Rhea 6,7-dimethyl-8-(1-D-ribityl)lumazine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/26153""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-028_d2f48fb35e92	RHEA:26153	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26153		"[{""reference_id"": ""RHEA:26153"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:26153 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/26153']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:26153"", ""source_version"": ""139"", ""title"": ""Rhea 6,7-dimethyl-8-(1-D-ribityl)lumazine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/26153""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-029_89a3402c931c	RHEA:26153	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26153		"[{""reference_id"": ""RHEA:26153"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:26153 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/26153']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:26153"", ""source_version"": ""139"", ""title"": ""Rhea 6,7-dimethyl-8-(1-D-ribityl)lumazine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/26153""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-030_cbb478018d0e	RHEA:26153	pathwaymech:produces	CHEBI:58201	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26153		"[{""reference_id"": ""RHEA:26153"", ""source_assertion"": ""Rhea lists CHEBI:58201 on the products side of RHEA:26153 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/26153']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:26153"", ""source_version"": ""139"", ""title"": ""Rhea 6,7-dimethyl-8-(1-D-ribityl)lumazine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/26153""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-031_688fe1dd9679	CHEBI:15378	pathwaymech:consumes	RHEA:20773	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20773		"[{""reference_id"": ""RHEA:20773"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:20773 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20773']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20773"", ""source_version"": ""139"", ""title"": ""Rhea riboflavin-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/20773""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-032_7cf12da2536d	CHEBI:58201	pathwaymech:consumes	RHEA:20773	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20773		"[{""reference_id"": ""RHEA:20773"", ""source_assertion"": ""Rhea lists CHEBI:58201 on the substrates side of RHEA:20773 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20773']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20773"", ""source_version"": ""139"", ""title"": ""Rhea riboflavin-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/20773""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-033_c759c02b0b60	RHEA:20773	pathwaymech:produces	CHEBI:15934	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20773		"[{""reference_id"": ""RHEA:20773"", ""source_assertion"": ""Rhea lists CHEBI:15934 on the products side of RHEA:20773 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20773']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20773"", ""source_version"": ""139"", ""title"": ""Rhea riboflavin-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/20773""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-034_021f1ba0733c	RHEA:20773	pathwaymech:produces	CHEBI:57986	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20773		"[{""reference_id"": ""RHEA:20773"", ""source_assertion"": ""Rhea lists CHEBI:57986 on the products side of RHEA:20773 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20773']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20773"", ""source_version"": ""139"", ""title"": ""Rhea riboflavin-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/20773""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-035_46be471f3efd	CHEBI:30616	pathwaymech:consumes	RHEA:14358	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14358		"[{""reference_id"": ""RHEA:14358"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:14358 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14358']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14358"", ""source_version"": ""139"", ""title"": ""Rhea FMN-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14358""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-036_5ce931dff4db	CHEBI:57986	pathwaymech:consumes	RHEA:14358	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14358		"[{""reference_id"": ""RHEA:14358"", ""source_assertion"": ""Rhea lists CHEBI:57986 on the substrates side of RHEA:14358 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14358']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14358"", ""source_version"": ""139"", ""title"": ""Rhea FMN-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14358""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-037_cf66d4716583	RHEA:14358	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14358		"[{""reference_id"": ""RHEA:14358"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:14358 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14358']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14358"", ""source_version"": ""139"", ""title"": ""Rhea FMN-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14358""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-038_6ea811faae30	RHEA:14358	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14358		"[{""reference_id"": ""RHEA:14358"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:14358 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14358']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14358"", ""source_version"": ""139"", ""title"": ""Rhea FMN-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14358""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-039_240f8c1e03fa	RHEA:14358	pathwaymech:produces	CHEBI:58210	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14358		"[{""reference_id"": ""RHEA:14358"", ""source_assertion"": ""Rhea lists CHEBI:58210 on the products side of RHEA:14358 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14358']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14358"", ""source_version"": ""139"", ""title"": ""Rhea FMN-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14358""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-040_3aca09f05216	CHEBI:15378	pathwaymech:consumes	RHEA:17238	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17238		"[{""reference_id"": ""RHEA:17238"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:17238 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17238']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17238"", ""source_version"": ""139"", ""title"": ""Rhea FAD-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17238""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-041_45669d6de6f9	CHEBI:30616	pathwaymech:consumes	RHEA:17238	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17238		"[{""reference_id"": ""RHEA:17238"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:17238 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17238']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17238"", ""source_version"": ""139"", ""title"": ""Rhea FAD-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17238""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-042_649cec8c9d10	CHEBI:58210	pathwaymech:consumes	RHEA:17238	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17238		"[{""reference_id"": ""RHEA:17238"", ""source_assertion"": ""Rhea lists CHEBI:58210 on the substrates side of RHEA:17238 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17238']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17238"", ""source_version"": ""139"", ""title"": ""Rhea FAD-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17238""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-043_1cd4eded3fd9	RHEA:17238	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17238		"[{""reference_id"": ""RHEA:17238"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:17238 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17238']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17238"", ""source_version"": ""139"", ""title"": ""Rhea FAD-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17238""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-044_e7f4ca90754c	RHEA:17238	pathwaymech:produces	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17238		"[{""reference_id"": ""RHEA:17238"", ""source_assertion"": ""Rhea lists CHEBI:57692 on the products side of RHEA:17238 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17238']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17238"", ""source_version"": ""139"", ""title"": ""Rhea FAD-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17238""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-045_ecab090e9f07	EC:3.5.4.25	pathwaymech:catalyzes	RHEA:23705	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23704		"[{""reference_id"": ""RHEA:23704"", ""source_assertion"": ""Rhea associates EC:3.5.4.25 with the reaction family containing RHEA:23705."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:23704"", ""source_version"": ""139"", ""title"": ""Rhea GTP cyclohydrolase II reaction"", ""url"": ""https://www.rhea-db.org/rhea/23704""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-046_bc28ccfc8647	EC:3.5.4.26	pathwaymech:catalyzes	RHEA:21869	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21868		"[{""reference_id"": ""RHEA:21868"", ""source_assertion"": ""Rhea associates EC:3.5.4.26 with the reaction family containing RHEA:21869."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:21868"", ""source_version"": ""139"", ""title"": ""Rhea diaminohydroxyphosphoribosylaminopyrimidine deaminase reaction"", ""url"": ""https://www.rhea-db.org/rhea/21868""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-047_dfd17ca9557b	EC:1.1.1.193	pathwaymech:catalyzes	RHEA:17847	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17845		"[{""reference_id"": ""RHEA:17845"", ""source_assertion"": ""Rhea associates EC:1.1.1.193 with the reaction family containing RHEA:17847."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:17845"", ""source_version"": ""139"", ""title"": ""Rhea 5-amino-6-(5-phosphoribosylamino)uracil reductase reaction"", ""url"": ""https://www.rhea-db.org/rhea/17845""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-048_b57e0ddb89bf	EC:4.1.99.12	pathwaymech:catalyzes	RHEA:18458	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18457		"[{""reference_id"": ""RHEA:18457"", ""source_assertion"": ""Rhea associates EC:4.1.99.12 with the reaction family containing RHEA:18458."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:18457"", ""source_version"": ""139"", ""title"": ""Rhea 3,4-dihydroxy-2-butanone 4-phosphate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/18457""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-049_2053149c1c34	EC:3.1.3.104	pathwaymech:catalyzes	RHEA:25198	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25197		"[{""reference_id"": ""RHEA:25197"", ""source_assertion"": ""Rhea associates EC:3.1.3.104 with the reaction family containing RHEA:25198."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:25197"", ""source_version"": ""139"", ""title"": ""Rhea 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase reaction"", ""url"": ""https://www.rhea-db.org/rhea/25197""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-050_6044b74b4c5b	EC:2.5.1.78	pathwaymech:catalyzes	RHEA:26153	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26152		"[{""reference_id"": ""RHEA:26152"", ""source_assertion"": ""Rhea associates EC:2.5.1.78 with the reaction family containing RHEA:26153."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:26152"", ""source_version"": ""139"", ""title"": ""Rhea 6,7-dimethyl-8-ribityllumazine synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/26152""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-051_05a388ebe84f	EC:2.5.1.9	pathwaymech:catalyzes	RHEA:20773	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20772		"[{""reference_id"": ""RHEA:20772"", ""source_assertion"": ""Rhea associates EC:2.5.1.9 with the reaction family containing RHEA:20773."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:20772"", ""source_version"": ""139"", ""title"": ""Rhea riboflavin synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/20772""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-052_2586bea43542	EC:2.7.1.26	pathwaymech:catalyzes	RHEA:14358	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14357		"[{""reference_id"": ""RHEA:14357"", ""source_assertion"": ""Rhea associates EC:2.7.1.26 with the reaction family containing RHEA:14358."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:14357"", ""source_version"": ""139"", ""title"": ""Rhea riboflavin kinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/14357""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-053_e4dcd1e703d2	EC:2.7.7.2	pathwaymech:catalyzes	RHEA:17238	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17237		"[{""reference_id"": ""RHEA:17237"", ""source_assertion"": ""Rhea associates EC:2.7.7.2 with the reaction family containing RHEA:17238."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:17237"", ""source_version"": ""139"", ""title"": ""Rhea FAD synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/17237""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-054_69aa681c614c	RHEA:14358	pathwaymech:precedes	RHEA:17238	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RIBOSYN2-PWY		"[{""reference_id"": ""MetaCyc:RIBOSYN2-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:14358 before RHEA:17238 in this pathway. Shared intermediate: CHEBI:58210."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:RIBOSYN2-PWY"", ""source_sha256"": ""38095a0212a8767274c72eac6e94b2a229920f0bab122af972b4306e4cc7ba70"", ""source_version"": ""22.5"", ""title"": ""MetaCyc flavin biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:RIBOSYN2-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-055_843bc720b029	RHEA:17847	pathwaymech:precedes	RHEA:25198	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RIBOSYN2-PWY		"[{""reference_id"": ""MetaCyc:RIBOSYN2-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:17847 before RHEA:25198 in this pathway. Shared intermediate: CHEBI:58421."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:RIBOSYN2-PWY"", ""source_sha256"": ""38095a0212a8767274c72eac6e94b2a229920f0bab122af972b4306e4cc7ba70"", ""source_version"": ""22.5"", ""title"": ""MetaCyc flavin biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:RIBOSYN2-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-056_c29b6d34e2be	RHEA:18458	pathwaymech:precedes	RHEA:26153	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RIBOSYN2-PWY		"[{""reference_id"": ""MetaCyc:RIBOSYN2-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:18458 before RHEA:26153 in this pathway. Shared intermediate: CHEBI:58830."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:RIBOSYN2-PWY"", ""source_sha256"": ""38095a0212a8767274c72eac6e94b2a229920f0bab122af972b4306e4cc7ba70"", ""source_version"": ""22.5"", ""title"": ""MetaCyc flavin biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:RIBOSYN2-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-057_673891d717e4	RHEA:20773	pathwaymech:precedes	RHEA:14358	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RIBOSYN2-PWY		"[{""reference_id"": ""MetaCyc:RIBOSYN2-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:20773 before RHEA:14358 in this pathway. Shared intermediate: CHEBI:57986."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:RIBOSYN2-PWY"", ""source_sha256"": ""38095a0212a8767274c72eac6e94b2a229920f0bab122af972b4306e4cc7ba70"", ""source_version"": ""22.5"", ""title"": ""MetaCyc flavin biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:RIBOSYN2-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-058_7adeb6657748	RHEA:21869	pathwaymech:precedes	RHEA:17847	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RIBOSYN2-PWY		"[{""reference_id"": ""MetaCyc:RIBOSYN2-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:21869 before RHEA:17847 in this pathway. Shared intermediate: CHEBI:58453."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:RIBOSYN2-PWY"", ""source_sha256"": ""38095a0212a8767274c72eac6e94b2a229920f0bab122af972b4306e4cc7ba70"", ""source_version"": ""22.5"", ""title"": ""MetaCyc flavin biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:RIBOSYN2-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-059_98f6ff7ef8e6	RHEA:23705	pathwaymech:precedes	RHEA:21869	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RIBOSYN2-PWY		"[{""reference_id"": ""MetaCyc:RIBOSYN2-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:23705 before RHEA:21869 in this pathway. Shared intermediate: CHEBI:58614."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:RIBOSYN2-PWY"", ""source_sha256"": ""38095a0212a8767274c72eac6e94b2a229920f0bab122af972b4306e4cc7ba70"", ""source_version"": ""22.5"", ""title"": ""MetaCyc flavin biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:RIBOSYN2-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-060_51dc670fbc7e	RHEA:25198	pathwaymech:precedes	RHEA:26153	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RIBOSYN2-PWY		"[{""reference_id"": ""MetaCyc:RIBOSYN2-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:25198 before RHEA:26153 in this pathway. Shared intermediate: CHEBI:15934."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:RIBOSYN2-PWY"", ""source_sha256"": ""38095a0212a8767274c72eac6e94b2a229920f0bab122af972b4306e4cc7ba70"", ""source_version"": ""22.5"", ""title"": ""MetaCyc flavin biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:RIBOSYN2-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-061_ccf05d063d31	RHEA:26153	pathwaymech:precedes	RHEA:20773	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RIBOSYN2-PWY		"[{""reference_id"": ""MetaCyc:RIBOSYN2-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:26153 before RHEA:20773 in this pathway. Shared intermediate: CHEBI:58201."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:RIBOSYN2-PWY"", ""source_sha256"": ""38095a0212a8767274c72eac6e94b2a229920f0bab122af972b4306e4cc7ba70"", ""source_version"": ""22.5"", ""title"": ""MetaCyc flavin biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:RIBOSYN2-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-062_6cc9e5f5f508	UniProtKB:P0A7I7	pathwaymech:enables	RHEA:23705	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A7I7		"[{""reference_id"": ""UniProtKB:P0A7I7"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A7I7 with catalytic activity for the reaction family of RHEA:23705. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A7I7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A7I7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A7I7.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-063_5141043c7826	UniProtKB:P0A7I7	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A7I7		"[{""reference_id"": ""UniProtKB:P0A7I7"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P0A7I7 (evidence: ECO:0000269). Binds 1 zinc ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0A7I7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A7I7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A7I7.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-064_02a23bb9e737	UniProtKB:P0A7J0	pathwaymech:enables	RHEA:18458	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A7J0		"[{""reference_id"": ""UniProtKB:P0A7J0"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A7J0 with catalytic activity for the reaction family of RHEA:18458. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A7J0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A7J0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A7J0.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-065_9cb1d182b74a	UniProtKB:P0A7J0	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A7J0		"[{""reference_id"": ""UniProtKB:P0A7J0"", ""source_assertion"": ""UniProt locates UniProtKB:P0A7J0 in Cell membrane (SL-0039, mapped by UniProt to GO:0005886). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A7J0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A7J0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A7J0.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-066_19b655d363ab	UniProtKB:P0A7J0	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A7J0		"[{""reference_id"": ""UniProtKB:P0A7J0"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P0A7J0 (evidence: ECO:0000269). Binds 2 divalent metal cations per subunit. Magnesium or manganese."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0A7J0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A7J0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A7J0.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-067_cbf0f9fd1edc	UniProtKB:P0A7J0	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A7J0		"[{""reference_id"": ""UniProtKB:P0A7J0"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P0A7J0 (evidence: ECO:0000255). Binds 2 divalent metal cations per subunit. Magnesium or manganese."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0A7J0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A7J0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A7J0.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-068_1adeac5513ea	UniProtKB:P0ADP0	pathwaymech:enables	RHEA:25198	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ADP0		"[{""reference_id"": ""UniProtKB:P0ADP0"", ""source_assertion"": ""UniProt annotates UniProtKB:P0ADP0 with catalytic activity for the reaction family of RHEA:25198. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0ADP0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0ADP0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ADP0.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-069_6f48e287310c	UniProtKB:P0ADP0	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ADP0		"[{""reference_id"": ""UniProtKB:P0ADP0"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P0ADP0 (evidence: ECO:0000269). Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0ADP0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0ADP0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ADP0.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-070_c6a7156508f1	UniProtKB:P0ADP0	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ADP0		"[{""reference_id"": ""UniProtKB:P0ADP0"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P0ADP0 (evidence: ECO:0000269). Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0ADP0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0ADP0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ADP0.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-071_0cb07f270245	UniProtKB:P0ADP0	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ADP0		"[{""reference_id"": ""UniProtKB:P0ADP0"", ""source_assertion"": ""UniProt lists CHEBI:48828 as a cofactor of UniProtKB:P0ADP0 (evidence: ECO:0000269). Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0ADP0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0ADP0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ADP0.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-072_24aedd36a5d1	UniProtKB:P0ADP0	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ADP0		"[{""reference_id"": ""UniProtKB:P0ADP0"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P0ADP0 (evidence: ECO:0000269). Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0ADP0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0ADP0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ADP0.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-073_7e4faff5da81	UniProtKB:P0AFU8	pathwaymech:enables	RHEA:20773	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AFU8		"[{""reference_id"": ""UniProtKB:P0AFU8"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AFU8 with catalytic activity for the reaction family of RHEA:20773. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AFU8"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AFU8 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AFU8.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-074_a537c1ee10bd	UniProtKB:P0AG40	pathwaymech:enables	RHEA:14358	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AG40		"[{""reference_id"": ""UniProtKB:P0AG40"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AG40 with catalytic activity for the reaction family of RHEA:14358. Annotation evidence: ECO:0000250; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AG40"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AG40 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AG40.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-075_a3fdffffda19	UniProtKB:P0AG40	pathwaymech:enables	RHEA:17238	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AG40		"[{""reference_id"": ""UniProtKB:P0AG40"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AG40 with catalytic activity for the reaction family of RHEA:17238. Annotation evidence: ECO:0000250; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AG40"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AG40 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AG40.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-076_526da498bd47	UniProtKB:P25539	pathwaymech:enables	RHEA:21869	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P25539		"[{""reference_id"": ""UniProtKB:P25539"", ""source_assertion"": ""UniProt annotates UniProtKB:P25539 with catalytic activity for the reaction family of RHEA:21869. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P25539"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P25539 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P25539.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-077_b3c182733e92	UniProtKB:P25539	pathwaymech:enables	RHEA:17847	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P25539		"[{""reference_id"": ""UniProtKB:P25539"", ""source_assertion"": ""UniProt annotates UniProtKB:P25539 with catalytic activity for the reaction family of RHEA:17847. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P25539"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P25539 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P25539.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-078_87d6aab0d4b0	UniProtKB:P25539	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P25539		"[{""reference_id"": ""UniProtKB:P25539"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P25539 (evidence: ECO:0000250). Binds 1 zinc ion."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P25539"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P25539 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P25539.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-079_3d92acb35a72	UniProtKB:P61714	pathwaymech:enables	RHEA:26153	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P61714		"[{""reference_id"": ""UniProtKB:P61714"", ""source_assertion"": ""UniProt annotates UniProtKB:P61714 with catalytic activity for the reaction family of RHEA:26153. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P61714"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P61714 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P61714.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-080_ac90ad72e8e6	UniProtKB:P75809	pathwaymech:enables	RHEA:25198	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P75809		"[{""reference_id"": ""UniProtKB:P75809"", ""source_assertion"": ""UniProt annotates UniProtKB:P75809 with catalytic activity for the reaction family of RHEA:25198. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P75809"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P75809 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75809.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-081_90804320be4d	UniProtKB:P75809	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P75809		"[{""reference_id"": ""UniProtKB:P75809"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P75809 (evidence: ECO:0000269). Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P75809"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P75809 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75809.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-082_16ad4c1084b1	UniProtKB:P75809	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P75809		"[{""reference_id"": ""UniProtKB:P75809"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P75809 (evidence: ECO:0000269). Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P75809"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P75809 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75809.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-083_70866debc71e	UniProtKB:P75809	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P75809		"[{""reference_id"": ""UniProtKB:P75809"", ""source_assertion"": ""UniProt lists CHEBI:48828 as a cofactor of UniProtKB:P75809 (evidence: ECO:0000269). Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P75809"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P75809 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75809.json""}]"	""
pathwaymech:MetaCyc_RIBOSYN2-PWY_edge-084_4faffddf0578	UniProtKB:P75809	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P75809		"[{""reference_id"": ""UniProtKB:P75809"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P75809 (evidence: ECO:0000269). Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P75809"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P75809 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75809.json""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-001_4865bf0cdd98	gomodel:1.5.1.15-RXN	RO:0002234	CHEBI:57455	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02046	Corrected the methenyl endpoint; the distinct methylene input is retained.	"[{""reference_id"": ""UniProtKB:Q02046"", ""source_assertion"": ""Q02046 RHEA:22892 distinguishes the methenyl folate CHEBI:57455 from the methylene folate; the native GO-CAM CHEBI:20502 endpoint incorrectly merged these oxidation states."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2405/comments/1""}]"	"[{""id"": ""UniProtKB:Q02046"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02046 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-002_0c40fb9a0391	gomodel:GCVMULTI-RXN	BFO:0000050	GO:0046655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:GCVMULTI-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-697/YeastPathways_PWY3O-697."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/1; endpoint types: /individuals/32/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-004_3cc7625f6fb8	gomodel:DIHYDROFOLATEREDUCT-RXN	BFO:0000050	GO:0046655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATEREDUCT-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-697/YeastPathways_PWY3O-697."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/3; endpoint types: /individuals/30/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-005_625f0d361ec4	gomodel:GCVMULTI-RXN	BFO:0000066	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000218158|gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:GCVMULTI-RXN BFO:0000066 gomodel:YeastPathways_PWY3O-697/66a3e0bb00001309."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/4; endpoint types: /individuals/32/type; /individuals/203/type""}, {""reference_id"": ""SGD:S000218158"", ""source_assertion"": ""Complex Portal CPX-1268 places this complex's catalytic function in the mitochondrion."", ""source_locator"": ""CPX-1268.json#/functions/0""}]"	"[{""id"": ""SGD:S000218158"", ""source_sha256"": ""e4fe5081d0a6516ee143b07c7e6cba8f584140019c9d5eaefefaaf770559764b"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2018-03-21"", ""title"": ""Complex Portal CPX-1268: Glycine decarboxylase multienzyme complex"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1268""}, {""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-006_e9f7dc0e690d	gomodel:YeastPathways_PWY3O-697/6a4c244800005519	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005519 RO:0002233 gomodel:YeastPathways_PWY3O-697/6a4c244800005520."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/5; endpoint types: /individuals/171/type; /individuals/172/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-007_33abfb92d5b0	gomodel:YeastPathways_PWY3O-697/6a4c244800005502	RO:0002413	gomodel:YeastPathways_PWY3O-697/6a4c244800005519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005502 RO:0002413 gomodel:YeastPathways_PWY3O-697/6a4c244800005519."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/6; endpoint types: /individuals/155/type; /individuals/171/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-009_cc2b5ff57c7a	gomodel:DIHYDROFOLATEREDUCT-RXN	RO:0002234	CHEBI:67016	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATEREDUCT-RXN RO:0002234 gomodel:YeastPathways_PWY3O-697/66b5638000000268."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/8; endpoint types: /individuals/30/type; /individuals/205/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-011_f367dc751259	gomodel:YeastPathways_PWY3O-697/6a4c244800005519	BFO:0000050	GO:0046655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005519 BFO:0000050 gomodel:YeastPathways_PWY3O-697/YeastPathways_PWY3O-697."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/10; endpoint types: /individuals/171/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-012_241e943ece0d	gomodel:THYMIDYLATESYN-RXN	RO:0002234	CHEBI:63528	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:THYMIDYLATESYN-RXN RO:0002234 gomodel:CHEBI_63528_THYMIDYLATESYN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/11; endpoint types: /individuals/36/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-013_48e400ac68e5	gomodel:GCVMULTI-RXN	RO:0002233	CHEBI:57305	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:GCVMULTI-RXN RO:0002233 gomodel:CHEBI_57305_GCVMULTI-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/12; endpoint types: /individuals/32/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-014_151036066fe9	gomodel:FORMATETHFLIG-RXN	BFO:0000050	GO:0046655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:FORMATETHFLIG-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-697/YeastPathways_PWY3O-697."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/13; endpoint types: /individuals/31/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-017_828c3717c208	gomodel:1.5.1.20-RXN	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:1.5.1.20-RXN RO:0002234 gomodel:CHEBI_57540_1.5.1.20-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/16; endpoint types: /individuals/90/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-018_f16eb766a718	gomodel:FORMATETHFLIG-RXN	RO:0002234	CHEBI:67016	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:FORMATETHFLIG-RXN RO:0002234 gomodel:YeastPathways_PWY3O-697/66b5638000000275."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/17; endpoint types: /individuals/31/type; /individuals/210/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-019_c536516ce3a5	gomodel:1.5.1.20-RXN	RO:0002234	CHEBI:20612	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:1.5.1.20-RXN RO:0002234 gomodel:YeastPathways_PWY3O-697/66a3e0bb00001215."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/18; endpoint types: /individuals/90/type; /individuals/191/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-020_2192b0843fa8	gomodel:YeastPathways_PWY3O-697/6a4c244800005468	BFO:0000050	GO:0046655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005468 BFO:0000050 gomodel:YeastPathways_PWY3O-697/YeastPathways_PWY3O-697."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/19; endpoint types: /individuals/123/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-023_b4a29f08eec0	gomodel:YeastPathways_PWY3O-697/6a4c244800005468	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005468 RO:0002234 gomodel:YeastPathways_PWY3O-697/6a4c244800005470."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/22; endpoint types: /individuals/123/type; /individuals/125/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-024_3e17d9c0756a	gomodel:YeastPathways_PWY3O-697/6a4c244800005502	RO:0002233	CHEBI:67016	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005502 RO:0002233 gomodel:YeastPathways_PWY3O-697/6a4c244800005504."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/23; endpoint types: /individuals/155/type; /individuals/157/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-025_087f99d53d8f	gomodel:YeastPathways_PWY3O-697/6a4c244800005448	RO:0002234	CHEBI:15740	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005448 RO:0002234 gomodel:YeastPathways_PWY3O-697/6a4c244800005452."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/24; endpoint types: /individuals/104/type; /individuals/108/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-026_f16a9876d2a1	gomodel:1.5.1.15-RXN	BFO:0000050	GO:0046655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:1.5.1.15-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-697/YeastPathways_PWY3O-697."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/25; endpoint types: /individuals/89/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-027_da988c81349e	gomodel:METHENYLTHFCYCLOHYDRO-RXN	RO:0002234	CHEBI:134413	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:METHENYLTHFCYCLOHYDRO-RXN RO:0002234 gomodel:CHEBI_134413_METHENYLTHFCYCLOHYDRO-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/26; endpoint types: /individuals/34/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-028_aec4e0d3a739	gomodel:YeastPathways_PWY3O-697/6a4c244800005448	BFO:0000066	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005448 BFO:0000066 gomodel:YeastPathways_PWY3O-697/6a4c244800005456."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/27; endpoint types: /individuals/104/type; /individuals/111/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-029_d4bbfe10a4f8	gomodel:GLYOHMETRANS-RXN	RO:0002233	CHEBI:33384	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:GLYOHMETRANS-RXN RO:0002233 gomodel:CHEBI_33384_GLYOHMETRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/28; endpoint types: /individuals/33/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-031_33c594e32170	gomodel:1.5.1.20-RXN	RO:0002233	CHEBI:20502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:1.5.1.20-RXN RO:0002233 gomodel:CHEBI_20502_GLYOHMETRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/30; endpoint types: /individuals/90/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-033_03b189aaaa13	SGD:S000000288	pathwaymech:enables	gomodel:YeastPathways_PWY3O-697/6a4c244800005448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005448 RO:0002333 gomodel:YeastPathways_PWY3O-697/6a4c244800005455."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/32; endpoint types: /individuals/104/type; /individuals/110/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-034_1ff9ffd9429d	gomodel:GLYOHMETRANS-RXN	RO:0002233	CHEBI:67016	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:GLYOHMETRANS-RXN RO:0002233 gomodel:YeastPathways_PWY3O-697/6a4c244800005435."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/33; endpoint types: /individuals/33/type; /individuals/92/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-038_2160b477e9dd	SGD:S000003436	pathwaymech:enables	gomodel:FORMATETHFLIG-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:FORMATETHFLIG-RXN RO:0002333 gomodel:YGR204W-MONOMER_FORMATETHFLIG-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/37; endpoint types: /individuals/31/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-039_3c3ed7c12993	gomodel:METHYLENETHFDEHYDROG-NADP-RXN	RO:0002233	CHEBI:20502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:METHYLENETHFDEHYDROG-NADP-RXN RO:0002233 gomodel:CHEBI_20502_GLYOHMETRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/38; endpoint types: /individuals/35/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-040_b5bf2433c09b	gomodel:YeastPathways_PWY3O-697/6a4c244800005519	RO:0002234	CHEBI:20612	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005519 RO:0002234 gomodel:YeastPathways_PWY3O-697/6a4c244800005523."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/39; endpoint types: /individuals/171/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-041_30a75abe5995	gomodel:THYMIDYLATESYN-RXN	RO:0002413	gomodel:DIHYDROFOLATEREDUCT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:THYMIDYLATESYN-RXN RO:0002413 gomodel:DIHYDROFOLATEREDUCT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/40; endpoint types: /individuals/36/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-042_fd0550485928	gomodel:FORMATETHFLIG-RXN	RO:0002233	CHEBI:134413	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:FORMATETHFLIG-RXN RO:0002233 gomodel:CHEBI_134413_METHENYLTHFCYCLOHYDRO-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/41; endpoint types: /individuals/31/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-043_20f6eb7fa63f	gomodel:GLYOHMETRANS-RXN	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:GLYOHMETRANS-RXN RO:0002234 gomodel:CHEBI_15377_GLYOHMETRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/42; endpoint types: /individuals/33/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-045_60011da2a102	SGD:S000001788	pathwaymech:enables	gomodel:1.5.1.15-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:1.5.1.15-RXN RO:0002333 gomodel:YeastPathways_PWY3O-697/66a3e0bb00001221."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/44; endpoint types: /individuals/89/type; /individuals/197/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-046_96d797aa3fd8	gomodel:FORMATETHFLIG-RXN	BFO:0000066	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:FORMATETHFLIG-RXN BFO:0000066 gomodel:YeastPathways_PWY3O-697/66b5638000000273."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/45; endpoint types: /individuals/31/type; /individuals/208/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-047_cee3707382d7	gomodel:FORMATETHFLIG-RXN	RO:0002233	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:FORMATETHFLIG-RXN RO:0002233 gomodel:CHEBI_43474_FORMATETHFLIG-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/46; endpoint types: /individuals/31/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-049_bbad31fb1373	gomodel:YeastPathways_PWY3O-697/6a4c244800005519	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005519 BFO:0000066 gomodel:YeastPathways_PWY3O-697/6a4c244800005526."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/48; endpoint types: /individuals/171/type; /individuals/177/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-050_4b342bdf2c3e	SGD:S000218158	pathwaymech:enables	gomodel:GCVMULTI-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:GCVMULTI-RXN RO:0002333 gomodel:YeastPathways_PWY3O-697/66a3e0bb00001307."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/49; endpoint types: /individuals/32/type; /individuals/201/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-051_19cb00df7b65	gomodel:METHENYLTHFCYCLOHYDRO-RXN	RO:0002233	CHEBI:57455	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07245	Corrected the methenyl endpoint; the distinct methylene input is retained.	"[{""reference_id"": ""UniProtKB:P07245"", ""source_assertion"": ""P07245 RHEA:23700 distinguishes the methenyl folate CHEBI:57455 from the methylene folate; the native GO-CAM CHEBI:20502 endpoint incorrectly merged these oxidation states."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/160/comments/2""}]"	"[{""id"": ""UniProtKB:P07245"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07245 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-052_453c59a51c22	gomodel:METHYLENETHFDEHYDROG-NADP-RXN	RO:0002234	CHEBI:57455	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07245	Corrected the methenyl endpoint; the distinct methylene input is retained.	"[{""reference_id"": ""UniProtKB:P07245"", ""source_assertion"": ""P07245 RHEA:22812 distinguishes the methenyl folate CHEBI:57455 from the methylene folate; the native GO-CAM CHEBI:20502 endpoint incorrectly merged these oxidation states."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/160/comments/1""}]"	"[{""id"": ""UniProtKB:P07245"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07245 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-053_6cc05caab6a7	SGD:S000005944	pathwaymech:enables	gomodel:1.5.1.20-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:1.5.1.20-RXN RO:0002333 gomodel:YPL023C-MONOMER_1.5.1.20-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/52; endpoint types: /individuals/90/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-054_7c4be7708e5d	gomodel:YeastPathways_PWY3O-697/6a4c244800005448	RO:0002234	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005448 RO:0002234 gomodel:YeastPathways_PWY3O-697/6a4c244800005453."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/53; endpoint types: /individuals/104/type; /individuals/109/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-055_959eaac06770	SGD:S000005762	pathwaymech:enables	gomodel:DIHYDROFOLATEREDUCT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATEREDUCT-RXN RO:0002333 gomodel:YOR236W-MONOMER_DIHYDROFOLATEREDUCT-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/54; endpoint types: /individuals/30/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-056_c3529ce62664	gomodel:1.5.1.15-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:1.5.1.15-RXN BFO:0000066 gomodel:reaction_1.5.1.15-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/55; endpoint types: /individuals/89/type; /individuals/83/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-057_624372b7c135	gomodel:FORMATETHFLIG-RXN	RO:0002234	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:FORMATETHFLIG-RXN RO:0002234 gomodel:CHEBI_30616_FORMATETHFLIG-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/56; endpoint types: /individuals/31/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-058_701e4bdd09ae	gomodel:YeastPathways_PWY3O-697/6a4c244800005502	RO:0002413	gomodel:1.5.1.20-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005502 RO:0002413 gomodel:1.5.1.20-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/57; endpoint types: /individuals/155/type; /individuals/90/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-060_8238bb1dbfe4	SGD:S000003093	pathwaymech:enables	gomodel:YeastPathways_PWY3O-697/6a4c244800005519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005519 RO:0002333 gomodel:YeastPathways_PWY3O-697/6a4c244800005525."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/59; endpoint types: /individuals/171/type; /individuals/176/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-061_650bbcc7e718	gomodel:DIHYDROFOLATEREDUCT-RXN	RO:0002233	CHEBI:57451	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATEREDUCT-RXN RO:0002233 gomodel:CHEBI_57451_THYMIDYLATESYN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/60; endpoint types: /individuals/30/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-062_74f23c52b9e0	gomodel:1.5.1.20-RXN	BFO:0000050	GO:0046655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:1.5.1.20-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-697/YeastPathways_PWY3O-697."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/61; endpoint types: /individuals/90/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-063_9951d147792b	gomodel:YeastPathways_PWY3O-697/6a4c244800005519	RO:0002233	CHEBI:20502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005519 RO:0002233 gomodel:CHEBI_20502_GLYOHMETRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/62; endpoint types: /individuals/171/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-064_abd97fd530e2	gomodel:1.5.1.20-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:1.5.1.20-RXN BFO:0000066 gomodel:reaction_1.5.1.20-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/63; endpoint types: /individuals/90/type; /individuals/84/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-066_510dbf69ad37	gomodel:DIHYDROFOLATEREDUCT-RXN	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATEREDUCT-RXN RO:0002234 gomodel:CHEBI_58349_DIHYDROFOLATEREDUCT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/65; endpoint types: /individuals/30/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-067_d6bd08a78749	gomodel:1.5.1.15-RXN	RO:0002233	CHEBI:20502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:1.5.1.15-RXN RO:0002233 gomodel:CHEBI_20502_GLYOHMETRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/66; endpoint types: /individuals/89/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-068_808894853430	SGD:S000004048	pathwaymech:enables	gomodel:YeastPathways_PWY3O-697/6a4c244800005502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005502 RO:0002333 gomodel:YeastPathways_PWY3O-697/6a4c244800005507."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/67; endpoint types: /individuals/155/type; /individuals/160/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-069_6733cdbd567e	gomodel:THYMIDYLATESYN-RXN	RO:0002233	CHEBI:20502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:THYMIDYLATESYN-RXN RO:0002233 gomodel:CHEBI_20502_GCVMULTI-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/68; endpoint types: /individuals/36/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-070_185666ad56fe	gomodel:GCVMULTI-RXN	RO:0002234	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:GCVMULTI-RXN RO:0002234 gomodel:CHEBI_28938_GCVMULTI-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/69; endpoint types: /individuals/32/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-071_8aaa54aa37da	gomodel:YeastPathways_PWY3O-697/6a4c244800005502	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005502 BFO:0000066 gomodel:YeastPathways_PWY3O-697/6a4c244800005509."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/70; endpoint types: /individuals/155/type; /individuals/161/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-072_9d32c68d1797	SGD:S000000288	pathwaymech:enables	gomodel:YeastPathways_PWY3O-697/6a4c244800005468	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005468 RO:0002333 gomodel:YeastPathways_PWY3O-697/6a4c244800005471."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/71; endpoint types: /individuals/123/type; /individuals/126/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-073_92ff383dc180	gomodel:DIHYDROFOLATEREDUCT-RXN	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATEREDUCT-RXN RO:0002233 gomodel:CHEBI_57783_DIHYDROFOLATEREDUCT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/72; endpoint types: /individuals/30/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-074_5269b3c4883c	gomodel:1.5.1.15-RXN	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:1.5.1.15-RXN RO:0002234 gomodel:CHEBI_57945_1.5.1.15-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/73; endpoint types: /individuals/89/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-075_9a0e450d8d7f	gomodel:DIHYDROFOLATEREDUCT-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATEREDUCT-RXN BFO:0000066 gomodel:reaction_DIHYDROFOLATEREDUCT-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/74; endpoint types: /individuals/30/type; /individuals/85/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-076_82390172f6e5	gomodel:GLYOHMETRANS-RXN	RO:0002234	CHEBI:20502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:GLYOHMETRANS-RXN RO:0002234 gomodel:CHEBI_20502_GLYOHMETRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/75; endpoint types: /individuals/33/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-077_5cde243e3d5c	gomodel:THYMIDYLATESYN-RXN	BFO:0000050	GO:0046655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:THYMIDYLATESYN-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-697/YeastPathways_PWY3O-697."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/76; endpoint types: /individuals/36/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-078_bcaa65066cd7	gomodel:1.5.1.20-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:1.5.1.20-RXN RO:0002233 gomodel:CHEBI_15378_1.5.1.20-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/77; endpoint types: /individuals/90/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-079_00079e3d213a	gomodel:YeastPathways_PWY3O-697/6a4c244800005519	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11729203|UniProtKB:P53128	MET13 uses NADPH/NADP; the independently supported MET12 NADH branch remains.	"[{""reference_id"": ""UniProtKB:P53128"", ""source_assertion"": ""MET13 methylenetetrahydrofolate reductase uses NADPH/NADP, as annotated by RHEA:19817; its reduction direction consumes NADPH."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3945/comments/0""}, {""reference_id"": ""PMID:11729203"", ""source_assertion"": ""The experimental study identifies the yeast MET13-encoded reductase as NADPH-dependent."", ""source_locator"": ""PubMed abstract, MET13 cofactor-specificity statement""}]"	"[{""id"": ""PMID:11729203"", ""title"": ""Metabolic engineering in yeast demonstrates that S-adenosylmethionine controls flux through the methylenetetrahydrofolate reductase reaction in vivo"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/11729203/""}, {""id"": ""UniProtKB:P53128"", ""source_sha256"": ""9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P53128 catalytic annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-080_bae22fd0f050	gomodel:YeastPathways_PWY3O-697/6a4c244800005484	RO:0002234	CHEBI:57455	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09440	Corrected the methenyl endpoint; the distinct methylene input is retained.	"[{""reference_id"": ""UniProtKB:P09440"", ""source_assertion"": ""P09440 RHEA:22812 distinguishes the methenyl folate CHEBI:57455 from the methylene folate; the native GO-CAM CHEBI:20502 endpoint incorrectly merged these oxidation states."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/224/comments/1""}]"	"[{""id"": ""UniProtKB:P09440"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P09440 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-081_6cbe9a82ea78	gomodel:GLYOHMETRANS-RXN	RO:0002234	CHEBI:57305	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:GLYOHMETRANS-RXN RO:0002234 gomodel:CHEBI_57305_GLYOHMETRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/80; endpoint types: /individuals/33/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-082_a423defbadbf	gomodel:YeastPathways_PWY3O-697/6a4c244800005484	RO:0002233	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005484 RO:0002233 gomodel:YeastPathways_PWY3O-697/6a4c244800005485."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/81; endpoint types: /individuals/138/type; /individuals/139/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-083_6339198c0504	gomodel:GCVMULTI-RXN	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:GCVMULTI-RXN RO:0002233 gomodel:CHEBI_57540_GCVMULTI-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/82; endpoint types: /individuals/32/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-084_98003149259a	gomodel:YeastPathways_PWY3O-697/6a4c244800005468	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005468 RO:0002233 gomodel:YeastPathways_PWY3O-697/6a4c244800005469."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/83; endpoint types: /individuals/123/type; /individuals/124/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-085_52ab27a6a13a	gomodel:GCVMULTI-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:GCVMULTI-RXN RO:0002234 gomodel:CHEBI_16526_GCVMULTI-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/84; endpoint types: /individuals/32/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-086_6da2c659e3bd	SGD:S000000467	pathwaymech:enables	gomodel:GLYOHMETRANS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:GLYOHMETRANS-RXN RO:0002333 gomodel:YeastPathways_PWY3O-697/66b5638000000277."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/85; endpoint types: /individuals/33/type; /individuals/212/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-087_09494e8278d3	gomodel:YeastPathways_PWY3O-697/6a4c244800005448	RO:0002233	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005448 RO:0002233 gomodel:YeastPathways_PWY3O-697/6a4c244800005449."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/86; endpoint types: /individuals/104/type; /individuals/105/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-089_0a0e0df9b434	gomodel:THYMIDYLATESYN-RXN	RO:0002234	CHEBI:57451	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:THYMIDYLATESYN-RXN RO:0002234 gomodel:CHEBI_57451_THYMIDYLATESYN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/88; endpoint types: /individuals/36/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-090_d608e72ee5ac	gomodel:YeastPathways_PWY3O-697/6a4c244800005468	RO:0002233	CHEBI:57455	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09440	Corrected the methenyl endpoint; the distinct methylene input is retained.	"[{""reference_id"": ""UniProtKB:P09440"", ""source_assertion"": ""P09440 RHEA:23700 distinguishes the methenyl folate CHEBI:57455 from the methylene folate; the native GO-CAM CHEBI:20502 endpoint incorrectly merged these oxidation states."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/224/comments/2""}]"	"[{""id"": ""UniProtKB:P09440"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P09440 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-091_4bf7a88d27d4	gomodel:YeastPathways_PWY3O-697/6a4c244800005448	RO:0002233	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005448 RO:0002233 gomodel:YeastPathways_PWY3O-697/6a4c244800005450."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/90; endpoint types: /individuals/104/type; /individuals/106/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-092_d4e3f141109f	gomodel:METHYLENETHFDEHYDROG-NADP-RXN	RO:0002233	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:METHYLENETHFDEHYDROG-NADP-RXN RO:0002233 gomodel:CHEBI_58349_METHYLENETHFDEHYDROG-NADP-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/91; endpoint types: /individuals/35/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-093_c9a24f415083	gomodel:METHYLENETHFDEHYDROG-NADP-RXN	RO:0002234	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:METHYLENETHFDEHYDROG-NADP-RXN RO:0002234 gomodel:CHEBI_57783_METHYLENETHFDEHYDROG-NADP-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/92; endpoint types: /individuals/35/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-094_5d8e99ae0921	gomodel:FORMATETHFLIG-RXN	RO:0002233	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:FORMATETHFLIG-RXN RO:0002233 gomodel:CHEBI_456216_FORMATETHFLIG-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/93; endpoint types: /individuals/31/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-095_786b6ed8a10f	gomodel:METHENYLTHFCYCLOHYDRO-RXN	BFO:0000050	GO:0046655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:METHENYLTHFCYCLOHYDRO-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-697/YeastPathways_PWY3O-697."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/94; endpoint types: /individuals/34/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-096_6c7b302c74b1	gomodel:GCVMULTI-RXN	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:GCVMULTI-RXN RO:0002234 gomodel:CHEBI_57945_GCVMULTI-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/95; endpoint types: /individuals/32/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-097_26172ef906a0	gomodel:1.5.1.15-RXN	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:1.5.1.15-RXN RO:0002233 gomodel:CHEBI_57540_1.5.1.15-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/96; endpoint types: /individuals/89/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-098_aa77979e08cf	gomodel:YeastPathways_PWY3O-697/6a4c244800005502	RO:0002234	CHEBI:57305	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005502 RO:0002234 gomodel:YeastPathways_PWY3O-697/6a4c244800005506."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/97; endpoint types: /individuals/155/type; /individuals/159/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-099_ac2bb293a6b7	gomodel:1.5.1.20-RXN	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:1.5.1.20-RXN RO:0002233 gomodel:CHEBI_57945_1.5.1.20-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/98; endpoint types: /individuals/90/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-100_bfaadae632fc	gomodel:YeastPathways_PWY3O-697/6a4c244800005468	RO:0002234	CHEBI:134413	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005468 RO:0002234 gomodel:CHEBI_134413_METHENYLTHFCYCLOHYDRO-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/99; endpoint types: /individuals/123/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-101_65b765aab26e	gomodel:YeastPathways_PWY3O-697/6a4c244800005484	BFO:0000050	GO:0046655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005484 BFO:0000050 gomodel:YeastPathways_PWY3O-697/YeastPathways_PWY3O-697."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/100; endpoint types: /individuals/138/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-102_8b2fbf7ce28f	gomodel:METHYLENETHFDEHYDROG-NADP-RXN	BFO:0000050	GO:0046655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:METHYLENETHFDEHYDROG-NADP-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-697/YeastPathways_PWY3O-697."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/101; endpoint types: /individuals/35/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-103_0cd222fb5139	gomodel:GCVMULTI-RXN	RO:0002233	CHEBI:67016	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:GCVMULTI-RXN RO:0002233 gomodel:YeastPathways_PWY3O-697/6a4c244800005437."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/102; endpoint types: /individuals/32/type; /individuals/94/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-104_38f490977616	gomodel:GCVMULTI-RXN	RO:0002234	CHEBI:20502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:GCVMULTI-RXN RO:0002234 gomodel:CHEBI_20502_GLYOHMETRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/103; endpoint types: /individuals/32/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-105_c381e831b9dc	gomodel:YeastPathways_PWY3O-697/6a4c244800005519	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11729203|UniProtKB:P53128	MET13 uses NADPH/NADP; the independently supported MET12 NADH branch remains.	"[{""reference_id"": ""UniProtKB:P53128"", ""source_assertion"": ""MET13 methylenetetrahydrofolate reductase uses NADPH/NADP, as annotated by RHEA:19817; its reduction direction consumes NADPH."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3945/comments/0""}, {""reference_id"": ""PMID:11729203"", ""source_assertion"": ""The experimental study identifies the yeast MET13-encoded reductase as NADPH-dependent."", ""source_locator"": ""PubMed abstract, MET13 cofactor-specificity statement""}]"	"[{""id"": ""PMID:11729203"", ""title"": ""Metabolic engineering in yeast demonstrates that S-adenosylmethionine controls flux through the methylenetetrahydrofolate reductase reaction in vivo"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/11729203/""}, {""id"": ""UniProtKB:P53128"", ""source_sha256"": ""9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P53128 catalytic annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-106_6cf269a027ab	SGD:S000005600	pathwaymech:enables	gomodel:THYMIDYLATESYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:THYMIDYLATESYN-RXN RO:0002333 gomodel:YeastPathways_PWY3O-697/66a3e0bb00001212."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/105; endpoint types: /individuals/36/type; /individuals/189/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-107_88f338899891	gomodel:YeastPathways_PWY3O-697/6a4c244800005484	RO:0002234	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005484 RO:0002234 gomodel:YeastPathways_PWY3O-697/6a4c244800005486."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/106; endpoint types: /individuals/138/type; /individuals/140/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-108_e4f3ac49dfa8	gomodel:YeastPathways_PWY3O-697/6a4c244800005502	RO:0002234	CHEBI:20502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005502 RO:0002234 gomodel:CHEBI_20502_GLYOHMETRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/107; endpoint types: /individuals/155/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-110_68fca548a03d	gomodel:YeastPathways_PWY3O-697/6a4c244800005502	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005502 RO:0002234 gomodel:YeastPathways_PWY3O-697/6a4c244800005505."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/109; endpoint types: /individuals/155/type; /individuals/158/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-111_a9012b69cbca	gomodel:YeastPathways_PWY3O-697/6a4c244800005502	BFO:0000050	GO:0046655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005502 BFO:0000050 gomodel:YeastPathways_PWY3O-697/YeastPathways_PWY3O-697."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/110; endpoint types: /individuals/155/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-112_7a5695f4b349	gomodel:METHENYLTHFCYCLOHYDRO-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:METHENYLTHFCYCLOHYDRO-RXN RO:0002234 gomodel:CHEBI_15378_METHENYLTHFCYCLOHYDRO-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/111; endpoint types: /individuals/34/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-113_cf4bf014bbc5	SGD:S000003436	pathwaymech:enables	gomodel:METHYLENETHFDEHYDROG-NADP-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:METHYLENETHFDEHYDROG-NADP-RXN RO:0002333 gomodel:YGR204W-MONOMER_METHYLENETHFDEHYDROG-NADP-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/112; endpoint types: /individuals/35/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-114_d2b12e0604b8	gomodel:YeastPathways_PWY3O-697/6a4c244800005484	RO:0002233	CHEBI:20502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005484 RO:0002233 gomodel:CHEBI_20502_GLYOHMETRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/113; endpoint types: /individuals/138/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-116_7088423d67d1	gomodel:GLYOHMETRANS-RXN	BFO:0000050	GO:0046655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:GLYOHMETRANS-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-697/YeastPathways_PWY3O-697."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/115; endpoint types: /individuals/33/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-117_5cc83e9b2164	gomodel:YeastPathways_PWY3O-697/6a4c244800005468	BFO:0000066	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005468 BFO:0000066 gomodel:YeastPathways_PWY3O-697/6a4c244800005473."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/116; endpoint types: /individuals/123/type; /individuals/127/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-118_e77a937551b1	gomodel:YeastPathways_PWY3O-697/6a4c244800005448	BFO:0000050	GO:0046655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005448 BFO:0000050 gomodel:YeastPathways_PWY3O-697/YeastPathways_PWY3O-697."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/117; endpoint types: /individuals/104/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-119_1d8b5a4a5572	gomodel:METHENYLTHFCYCLOHYDRO-RXN	BFO:0000066	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:METHENYLTHFCYCLOHYDRO-RXN BFO:0000066 gomodel:YeastPathways_PWY3O-697/66b5638000000281."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/118; endpoint types: /individuals/34/type; /individuals/214/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-120_f6862648751d	SGD:S000000288	pathwaymech:enables	gomodel:YeastPathways_PWY3O-697/6a4c244800005484	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005484 RO:0002333 gomodel:YeastPathways_PWY3O-697/6a4c244800005487."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/119; endpoint types: /individuals/138/type; /individuals/141/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-121_16a7515ba07f	gomodel:FORMATETHFLIG-RXN	RO:0002234	CHEBI:15740	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:FORMATETHFLIG-RXN RO:0002234 gomodel:CHEBI_15740_FORMATETHFLIG-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/120; endpoint types: /individuals/31/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-122_fa34cafb9aba	gomodel:YeastPathways_PWY3O-697/6a4c244800005448	RO:0002234	CHEBI:67016	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005448 RO:0002234 gomodel:YeastPathways_PWY3O-697/6a4c244800005451."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/121; endpoint types: /individuals/104/type; /individuals/107/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-123_e0495a574a72	gomodel:METHENYLTHFCYCLOHYDRO-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:METHENYLTHFCYCLOHYDRO-RXN RO:0002233 gomodel:CHEBI_15377_METHENYLTHFCYCLOHYDRO-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/122; endpoint types: /individuals/34/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-124_cbeaf8f0ddfe	gomodel:YeastPathways_PWY3O-697/6a4c244800005502	RO:0002233	CHEBI:33384	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005502 RO:0002233 gomodel:YeastPathways_PWY3O-697/6a4c244800005503."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/123; endpoint types: /individuals/155/type; /individuals/156/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-126_7ef0646c434c	gomodel:YeastPathways_PWY3O-697/6a4c244800005448	RO:0002233	CHEBI:134413	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-697/6a4c244800005448 RO:0002233 gomodel:CHEBI_134413_METHENYLTHFCYCLOHYDRO-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/125; endpoint types: /individuals/104/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-127_3c8cf4fcd454	gomodel:DIHYDROFOLATEREDUCT-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATEREDUCT-RXN RO:0002233 gomodel:CHEBI_15378_DIHYDROFOLATEREDUCT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/126; endpoint types: /individuals/30/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-128_7c008eaead89	SGD:S000003436	pathwaymech:enables	gomodel:METHENYLTHFCYCLOHYDRO-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:METHENYLTHFCYCLOHYDRO-RXN RO:0002333 gomodel:YGR204W-MONOMER_METHENYLTHFCYCLOHYDRO-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/127; endpoint types: /individuals/34/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-129_5d9fa8fdb9f7	gomodel:METHYLENETHFDEHYDROG-NADP-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:METHYLENETHFDEHYDROG-NADP-RXN BFO:0000066 gomodel:reaction_METHYLENETHFDEHYDROG-NADP-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/128; endpoint types: /individuals/35/type; /individuals/87/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_edge-131_7e693143cbc8	gomodel:THYMIDYLATESYN-RXN	RO:0002233	CHEBI:246422	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-697		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_assertion"": ""The model asserts gomodel:THYMIDYLATESYN-RXN RO:0002233 gomodel:CHEBI_246422_THYMIDYLATESYN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-697.json#/facts/130; endpoint types: /individuals/36/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-697"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_PWY3O-697.json"", ""title"": ""SGD GO-CAM folate interconversions - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_complex-b6e1ff26ea0e_ed8d543d62f8	SGD:S000218158	BFO:0000051	SGD:S000001876	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000218158	ECO:0005547: inferred by curator; source stoichiometry minValue: 1, maxValue: 1	"[{""reference_id"": ""SGD:S000218158"", ""source_assertion"": ""Complex Portal CPX-1268 lists P09624 as a protein component; complex evidence is ECO:0005547: inferred by curator."", ""source_locator"": ""Complex Portal JSON #/participants/0; /evidenceType""}]"	"[{""id"": ""SGD:S000218158"", ""source_sha256"": ""e4fe5081d0a6516ee143b07c7e6cba8f584140019c9d5eaefefaaf770559764b"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2018-03-21"", ""title"": ""Complex Portal CPX-1268: Glycine decarboxylase multienzyme complex"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1268""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_complex-3eb24c3781ab_5fbb31e5159c	SGD:S000218158	BFO:0000051	UniProtKB:P39726	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000218158	ECO:0005547: inferred by curator; stoichiometry unspecified	"[{""reference_id"": ""SGD:S000218158"", ""source_assertion"": ""Complex Portal CPX-1268 lists P39726 as a protein component; complex evidence is ECO:0005547: inferred by curator."", ""source_locator"": ""Complex Portal JSON #/participants/1; /evidenceType""}]"	"[{""id"": ""SGD:S000218158"", ""source_sha256"": ""e4fe5081d0a6516ee143b07c7e6cba8f584140019c9d5eaefefaaf770559764b"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2018-03-21"", ""title"": ""Complex Portal CPX-1268: Glycine decarboxylase multienzyme complex"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1268""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_complex-4aa19f97514a_b3064b7f3865	SGD:S000218158	BFO:0000051	SGD:S000004801	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000218158	ECO:0005547: inferred by curator; stoichiometry unspecified	"[{""reference_id"": ""SGD:S000218158"", ""source_assertion"": ""Complex Portal CPX-1268 lists P49095 as a protein component; complex evidence is ECO:0005547: inferred by curator."", ""source_locator"": ""Complex Portal JSON #/participants/2; /evidenceType""}]"	"[{""id"": ""SGD:S000218158"", ""source_sha256"": ""e4fe5081d0a6516ee143b07c7e6cba8f584140019c9d5eaefefaaf770559764b"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2018-03-21"", ""title"": ""Complex Portal CPX-1268: Glycine decarboxylase multienzyme complex"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1268""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_complex-ba4a982d1c94_5dd0fb5acdf5	SGD:S000218158	BFO:0000051	SGD:S000002426	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000218158	ECO:0005547: inferred by curator; stoichiometry unspecified	"[{""reference_id"": ""SGD:S000218158"", ""source_assertion"": ""Complex Portal CPX-1268 lists P48015 as a protein component; complex evidence is ECO:0005547: inferred by curator."", ""source_locator"": ""Complex Portal JSON #/participants/3; /evidenceType""}]"	"[{""id"": ""SGD:S000218158"", ""source_sha256"": ""e4fe5081d0a6516ee143b07c7e6cba8f584140019c9d5eaefefaaf770559764b"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2018-03-21"", ""title"": ""Complex Portal CPX-1268: Glycine decarboxylase multienzyme complex"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1268""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_complex-8b778f4ec4b2_ca68c95abd04	SGD:S000218158	BFO:0000051	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000218158	ECO:0005547: inferred by curator; source stoichiometry minValue: 1, maxValue: 1	"[{""reference_id"": ""SGD:S000218158"", ""source_assertion"": ""Complex Portal CPX-1268 lists CHEBI:57692 as a small molecule component; complex evidence is ECO:0005547: inferred by curator."", ""source_locator"": ""Complex Portal JSON #/participants/4; /evidenceType""}]"	"[{""id"": ""SGD:S000218158"", ""source_sha256"": ""e4fe5081d0a6516ee143b07c7e6cba8f584140019c9d5eaefefaaf770559764b"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2018-03-21"", ""title"": ""Complex Portal CPX-1268: Glycine decarboxylase multienzyme complex"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1268""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_complex-cbafb3f90a4e_c1437191dddf	SGD:S000218158	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000218158	Complex location from the independent composition source; original GO-CAM activity locations are retained with their own provenance.	"[{""reference_id"": ""SGD:S000218158"", ""source_assertion"": ""Complex Portal CPX-1268 records cellular location GO:0005739 (mitochondrion); its evidence classification is ECO:0005547: inferred by curator."", ""source_locator"": ""Complex Portal JSON #/crossReferences/6; /evidenceType""}]"	"[{""id"": ""SGD:S000218158"", ""source_sha256"": ""e4fe5081d0a6516ee143b07c7e6cba8f584140019c9d5eaefefaaf770559764b"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2018-03-21"", ""title"": ""Complex Portal CPX-1268: Glycine decarboxylase multienzyme complex"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1268""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_location-d5a567a4d5a0_41fd347b74b8	SGD:S000000288	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09440	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:14576278); ECO:0000269 (PubMed:3528153)	"[{""reference_id"": ""UniProtKB:P09440"", ""source_assertion"": ""UniProtKB:P09440 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/224/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P09440"", ""source_assertion"": ""UniProtKB:P09440 has the exact SGD cross-reference SGD:S000000288."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/224/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P09440"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P09440 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_location-16807258a1bb_8ef4c5182ed2	SGD:S000003436	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07245	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P07245"", ""source_assertion"": ""UniProtKB:P07245 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/160/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07245"", ""source_assertion"": ""UniProtKB:P07245 has the exact SGD cross-reference SGD:S000003436."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/160/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07245"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07245 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_location-78788393776c_d88854c6c00d	SGD:S000003436	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07245	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P07245"", ""source_assertion"": ""UniProtKB:P07245 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/160/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07245"", ""source_assertion"": ""UniProtKB:P07245 has the exact SGD cross-reference SGD:S000003436."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/160/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07245"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07245 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_location-1a4fe9f77423_fa3ae97fe299	SGD:S000001788	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02046	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q02046"", ""source_assertion"": ""UniProtKB:Q02046 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2405/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q02046"", ""source_assertion"": ""UniProtKB:Q02046 has the exact SGD cross-reference SGD:S000001788."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2405/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q02046"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02046 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_location-6f85a8ac0b4a_60f33f708178	SGD:S000001788	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02046	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q02046"", ""source_assertion"": ""UniProtKB:Q02046 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2405/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q02046"", ""source_assertion"": ""UniProtKB:Q02046 has the exact SGD cross-reference SGD:S000001788."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2405/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q02046"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02046 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_location-07b87c20fdac_be87e37e058c	SGD:S000004048	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37291	Physical protein location from reviewed UniProt. ECO:0000305 (PubMed:8132653)	"[{""reference_id"": ""UniProtKB:P37291"", ""source_assertion"": ""UniProtKB:P37291 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3551/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P37291"", ""source_assertion"": ""UniProtKB:P37291 has the exact SGD cross-reference SGD:S000004048."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3551/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P37291"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P37291 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_location-40c811215059_0f12d4947219	SGD:S000000467	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37292	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P37292"", ""source_assertion"": ""UniProtKB:P37292 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1253/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P37292"", ""source_assertion"": ""UniProtKB:P37292 has the exact SGD cross-reference SGD:S000000467."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1253/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P37292"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P37292 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_location-f765f3f66695_52450de68181	SGD:S000005600	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06785	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:8132557) Source qualification: Localizes to the nuclear periphery	"[{""reference_id"": ""UniProtKB:P06785"", ""source_assertion"": ""UniProtKB:P06785 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/148/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P06785"", ""source_assertion"": ""UniProtKB:P06785 has the exact SGD cross-reference SGD:S000005600."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/148/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P06785"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06785 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_location-0eb5eb1a2d56_ed6e45701624	UniProtKB:P39726	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39726	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:14576278)	"[{""reference_id"": ""UniProtKB:P39726"", ""source_assertion"": ""UniProtKB:P39726 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1589/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P39726"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39726 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_location-2dcce5c5fdd8_59bd8da2b90e	SGD:S000001876	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09624	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P09624"", ""source_assertion"": ""UniProtKB:P09624 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/227/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P09624"", ""source_assertion"": ""UniProtKB:P09624 has the exact SGD cross-reference SGD:S000001876."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/227/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P09624"", ""source_sha256"": ""2ad9b6d84d565238960a053870fa90a6033bc212bbe1a4c9923fd55d7e7d7fc1"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P09624 SGD cross-reference"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_location-57647ef400cc_cd980503e2d2	SGD:S000004801	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P49095	Physical protein location from reviewed UniProt. ECO:0000250	"[{""reference_id"": ""UniProtKB:P49095"", ""source_assertion"": ""UniProtKB:P49095 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2023/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P49095"", ""source_assertion"": ""UniProtKB:P49095 has the exact SGD cross-reference SGD:S000004801."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2023/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P49095"", ""source_sha256"": ""2ad9b6d84d565238960a053870fa90a6033bc212bbe1a4c9923fd55d7e7d7fc1"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P49095 SGD cross-reference"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_location-f4502702bb14_5d358d95345a	SGD:S000002426	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P48015	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P48015"", ""source_assertion"": ""UniProtKB:P48015 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3893/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P48015"", ""source_assertion"": ""UniProtKB:P48015 has the exact SGD cross-reference SGD:S000002426."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3893/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P48015"", ""source_sha256"": ""2ad9b6d84d565238960a053870fa90a6033bc212bbe1a4c9923fd55d7e7d7fc1"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P48015 SGD cross-reference"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_location-8ca337c27328_43bafa6b0e30	gomodel:YeastPathways_PWY3O-697/6a4c244800005448	BFO:0000066	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09440	Activity compartment supported by an inspected functional annotation. ECO:0000269 (PubMed:3528153). Alternative isoenzymes may function elsewhere.	"[{""reference_id"": ""UniProtKB:P09440"", ""source_assertion"": ""UniProtKB:P09440 describes the corresponding catalytic function in the mitochondrion; this projection applies to the activity enabled by SGD:S000000288."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/224/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P09440"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P09440 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_location-fe4bb6bca136_524bd01883b6	gomodel:YeastPathways_PWY3O-697/6a4c244800005468	BFO:0000066	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09440	Activity compartment supported by an inspected functional annotation. ECO:0000269 (PubMed:3528153). Alternative isoenzymes may function elsewhere.	"[{""reference_id"": ""UniProtKB:P09440"", ""source_assertion"": ""UniProtKB:P09440 describes the corresponding catalytic function in the mitochondrion; this projection applies to the activity enabled by SGD:S000000288."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/224/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P09440"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P09440 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_location-26777ef597f0_b5d31c842f70	gomodel:YeastPathways_PWY3O-697/6a4c244800005484	BFO:0000066	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09440	Activity compartment supported by an inspected functional annotation. ECO:0000269 (PubMed:3528153). Alternative isoenzymes may function elsewhere.	"[{""reference_id"": ""UniProtKB:P09440"", ""source_assertion"": ""UniProtKB:P09440 describes the corresponding catalytic function in the mitochondrion; this projection applies to the activity enabled by SGD:S000000288."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/224/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P09440"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P09440 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_cofactor-a256cb60c7c6_bc278b2a3477	SGD:S000005944	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P46151	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P46151"", ""source_assertion"": ""UniProtKB:P46151 annotates CHEBI:57692 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3848/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P46151"", ""source_assertion"": ""UniProtKB:P46151 has the exact SGD cross-reference SGD:S000005944."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3848/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P46151"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P46151 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_cofactor-70afaaf8229b_39948663bf4c	SGD:S000003093	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53128	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: Historical assignment as a mitochondrial ribosomal protein does not contradict the current FAD annotation; retain its similarity-based evidence grade. UniProt evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P53128"", ""source_assertion"": ""UniProtKB:P53128 annotates CHEBI:57692 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3945/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P53128"", ""source_assertion"": ""UniProtKB:P53128 has the exact SGD cross-reference SGD:S000003093."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3945/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53128"", ""source_sha256"": ""9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P53128 catalytic annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_cofactor-8753e5da7087_f6d1194fbb28	SGD:S000004048	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37291	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P34897)	"[{""reference_id"": ""UniProtKB:P37291"", ""source_assertion"": ""UniProtKB:P37291 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3551/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P37291"", ""source_assertion"": ""UniProtKB:P37291 has the exact SGD cross-reference SGD:S000004048."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3551/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P37291"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P37291 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_cofactor-75a6a0c2563d_8ad336579f63	SGD:S000000467	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37292	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P37292"", ""source_assertion"": ""UniProtKB:P37292 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1253/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P37292"", ""source_assertion"": ""UniProtKB:P37292 has the exact SGD cross-reference SGD:S000000467."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1253/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P37292"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P37292 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_cofactor-3f8c905b738d_e94b8370a87c	UniProtKB:P39726	pathwaymech:has_cofactor	CHEBI:83088	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39726	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The source describes a covalently attached cofactor moiety. Keep that bound-state qualification; no free cosubstrate consumption is inferred. UniProt evidence: ECO:0000250 Binds 1 lipoyl cofactor covalently. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P39726"", ""source_assertion"": ""UniProtKB:P39726 annotates CHEBI:83088 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1589/comments/0/cofactors/0; /results/1589/comments/0/note""}]"	"[{""id"": ""UniProtKB:P39726"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39726 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_cofactor-4fb48c2e1250_ff0de51dad73	SGD:S000001876	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09624	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:9538259); ECO:0000269 (Reference:Ref.13) Binds 1 FAD per subunit. UniProt note evidence: ECO:0000269 (PubMed:9538259); ECO:0000269 (Reference:Ref.13)	"[{""reference_id"": ""UniProtKB:P09624"", ""source_assertion"": ""UniProtKB:P09624 annotates CHEBI:57692 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/227/comments/0/cofactors/0; /results/227/comments/0/note""}, {""reference_id"": ""UniProtKB:P09624"", ""source_assertion"": ""UniProtKB:P09624 has the exact SGD cross-reference SGD:S000001876."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/227/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P09624"", ""source_sha256"": ""2ad9b6d84d565238960a053870fa90a6033bc212bbe1a4c9923fd55d7e7d7fc1"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P09624 SGD cross-reference"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-697_cofactor-0a859255ac59_edecd8144699	SGD:S000004801	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P49095	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P49095"", ""source_assertion"": ""UniProtKB:P49095 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2023/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P49095"", ""source_assertion"": ""UniProtKB:P49095 has the exact SGD cross-reference SGD:S000004801."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2023/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P49095"", ""source_sha256"": ""2ad9b6d84d565238960a053870fa90a6033bc212bbe1a4c9923fd55d7e7d7fc1"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P49095 SGD cross-reference"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-001_abfd3723b07e	gomodel:RXN-2962	RO:0002233	CHEBI:13390	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:RXN-2962 RO:0002233 gomodel:CHEBI_13390_RXN-2962."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/0; endpoint types: /individuals/15/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-002_65f9a2ae6667	gomodel:RXN-2962	RO:0002233	CHEBI:58758	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:RXN-2962 RO:0002233 gomodel:CHEBI_58758_RXN-2961."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/1; endpoint types: /individuals/15/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-003_0212af3a89a9	gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN RO:0002233 gomodel:CHEBI_15377_S-FORMYLGLUTATHIONE-HYDROLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/2; endpoint types: /individuals/16/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-004_0a5650f99770	gomodel:1.2.1.2-RXN	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:1.2.1.2-RXN RO:0002233 gomodel:CHEBI_57540_1.2.1.2-RXN."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/3; endpoint types: /individuals/48/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-005_edfb3ce18f34	gomodel:RXN-2962	RO:0002234	CHEBI:57688	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:RXN-2962 RO:0002234 gomodel:CHEBI_57688_RXN-2962."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/4; endpoint types: /individuals/15/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-006_06a6c71479c1	gomodel:1.2.1.2-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:1.2.1.2-RXN RO:0002234 gomodel:CHEBI_16526_1.2.1.2-RXN."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/5; endpoint types: /individuals/48/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-007_3691b8a1cdc9	gomodel:1.2.1.2-RXN	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:1.2.1.2-RXN RO:0002234 gomodel:CHEBI_57945_1.2.1.2-RXN."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/6; endpoint types: /individuals/48/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-008_67df5ae4b3e3	gomodel:YeastPathways_PWY-1801-1/65692e7e00001183	pathwaymech:enables	gomodel:RXN-2961	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:RXN-2961 RO:0002333 gomodel:YeastPathways_PWY-1801-1/65692e7e00001183."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/7; endpoint types: /individuals/14/type; /individuals/53/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-009_8e78ac518471	gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN RO:0002234 gomodel:CHEBI_15378_S-FORMYLGLUTATHIONE-HYDROLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/8; endpoint types: /individuals/16/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-010_e5a5fe63e2f5	gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN	RO:0002234	CHEBI:57925	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN RO:0002234 gomodel:CHEBI_57925_S-FORMYLGLUTATHIONE-HYDROLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/9; endpoint types: /individuals/16/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-011_bf006f4a1a35	gomodel:RXN-2962	BFO:0000050	GO:0046294	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:RXN-2962 BFO:0000050 gomodel:YeastPathways_PWY-1801-1/YeastPathways_PWY-1801-1."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/10; endpoint types: /individuals/15/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-012_9c6a74f7c2df	SGD:S000005915	pathwaymech:enables	gomodel:1.2.1.2-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:1.2.1.2-RXN RO:0002333 gomodel:YOR388C-MONOMER_1.2.1.2-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/11; endpoint types: /individuals/48/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-013_18b87c3c754b	SGD:S000002327	pathwaymech:enables	gomodel:RXN-2962	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:RXN-2962 RO:0002333 gomodel:YDL168W-MONOMER_RXN-2962_controller."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/12; endpoint types: /individuals/15/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-014_83537508e24c	gomodel:RXN-2962	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:RXN-2962 RO:0002234 gomodel:CHEBI_15378_RXN-2962."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/13; endpoint types: /individuals/15/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-015_df9f698e9b5b	gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN BFO:0000066 gomodel:reaction_S-FORMYLGLUTATHIONE-HYDROLASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/14; endpoint types: /individuals/16/type; /individuals/47/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-016_c8de2574e110	gomodel:1.2.1.2-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:1.2.1.2-RXN BFO:0000066 gomodel:reaction_1.2.1.2-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/15; endpoint types: /individuals/48/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-017_cd93c0fceb89	gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN	BFO:0000050	GO:0046294	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN BFO:0000050 gomodel:YeastPathways_PWY-1801-1/YeastPathways_PWY-1801-1."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/16; endpoint types: /individuals/16/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-018_6f6965d0c8a0	gomodel:RXN-2962	RO:0002413	gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:RXN-2962 RO:0002413 gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/17; endpoint types: /individuals/15/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-019_f91e248cee16	gomodel:1.2.1.2-RXN	BFO:0000050	GO:0046294	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:1.2.1.2-RXN BFO:0000050 gomodel:YeastPathways_PWY-1801-1/YeastPathways_PWY-1801-1."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/18; endpoint types: /individuals/48/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-020_dc02980cb61c	gomodel:RXN-2961	RO:0002233	CHEBI:16842	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:RXN-2961 RO:0002233 gomodel:CHEBI_16842_RXN-2961."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/19; endpoint types: /individuals/14/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-021_2e17a7a0fb70	gomodel:RXN-2961	RO:0002233	CHEBI:57925	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:RXN-2961 RO:0002233 gomodel:CHEBI_57925_RXN-2961."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/20; endpoint types: /individuals/14/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-022_385cea0ac828	gomodel:RXN-2962	BFO:0000066	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:RXN-2962 BFO:0000066 gomodel:reaction_RXN-2962_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/21; endpoint types: /individuals/15/type; /individuals/46/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-023_0b92001f8b22	gomodel:RXN-2961	RO:0002234	CHEBI:58758	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:RXN-2961 RO:0002234 gomodel:CHEBI_58758_RXN-2961."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/22; endpoint types: /individuals/14/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-024_d5ae4053d162	SGD:S000003604	pathwaymech:enables	gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN RO:0002333 gomodel:YJL068C-MONOMER_S-FORMYLGLUTATHIONE-HYDROLASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/23; endpoint types: /individuals/16/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-025_078b70e440e8	gomodel:RXN-2962	RO:0002234	CHEBI:13392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:RXN-2962 RO:0002234 gomodel:CHEBI_13392_RXN-2962."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/24; endpoint types: /individuals/15/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-026_0eb406ce08df	gomodel:RXN-2961	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:RXN-2961 BFO:0000066 gomodel:reaction_RXN-2961_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/25; endpoint types: /individuals/14/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-027_b9623764d4f7	gomodel:RXN-2961	RO:0002413	gomodel:RXN-2962	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:RXN-2961 RO:0002413 gomodel:RXN-2962."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/26; endpoint types: /individuals/14/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-028_f11047a15806	gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN	RO:0002234	CHEBI:15740	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN RO:0002234 gomodel:CHEBI_15740_S-FORMYLGLUTATHIONE-HYDROLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/27; endpoint types: /individuals/16/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-029_36781c7ef57a	gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN	RO:0002233	CHEBI:57688	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN RO:0002233 gomodel:CHEBI_57688_RXN-2962."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/28; endpoint types: /individuals/16/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-030_4966be6a2f2a	gomodel:RXN-2961	BFO:0000050	GO:0046294	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:RXN-2961 BFO:0000050 gomodel:YeastPathways_PWY-1801-1/YeastPathways_PWY-1801-1."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/29; endpoint types: /individuals/14/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-031_ee8840eccf5e	gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN	RO:0002413	gomodel:1.2.1.2-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:S-FORMYLGLUTATHIONE-HYDROLASE-RXN RO:0002413 gomodel:1.2.1.2-RXN."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/30; endpoint types: /individuals/16/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_edge-032_34d17249e7cd	gomodel:1.2.1.2-RXN	RO:0002233	CHEBI:15740	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-1801-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_assertion"": ""The model asserts gomodel:1.2.1.2-RXN RO:0002233 gomodel:CHEBI_15740_S-FORMYLGLUTATHIONE-HYDROLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-1801-1.json#/facts/31; endpoint types: /individuals/48/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-1801-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-1801-1.json"", ""title"": ""GO-CAM formaldehyde oxidation II model YeastPathways_PWY-1801-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_location-be4c22557a5a_eef40b60ea3a	SGD:S000005915	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q08911	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03210); ECO:0000269 (PubMed:11921099)	"[{""reference_id"": ""UniProtKB:Q08911"", ""source_assertion"": ""UniProtKB:Q08911 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4271/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q08911"", ""source_assertion"": ""UniProtKB:Q08911 has the exact SGD cross-reference SGD:S000005915."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4271/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q08911"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q08911 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_location-b80b4f1b750d_ad4621414cbc	SGD:S000002327	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32771	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32771"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32771 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_location-091fe2fe90d3_86227aebe3bf	SGD:S000002327	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32771	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961)	"[{""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32771"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32771 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_location-ca6bf0305d21_0b7467232637	SGD:S000003604	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40363	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10427036)	"[{""reference_id"": ""UniProtKB:P40363"", ""source_assertion"": ""UniProtKB:P40363 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3743/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P40363"", ""source_assertion"": ""UniProtKB:P40363 has the exact SGD cross-reference SGD:S000003604."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3743/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40363"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40363 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-1801-1_cofactor-5ec0450d58bc_b5799434cb61	SGD:S000002327	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32771	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06525) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06525)	"[{""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/990/comments/0/cofactors/0; /results/990/comments/0/note""}, {""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/990/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32771"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32771 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:GO_1901281_fructoselysine-edge-001_1a9582e0865b	CHEBI:61393	pathwaymech:consumes	RHEA:28379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28379		"[{""reference_id"": ""RHEA:28379"", ""source_assertion"": ""Rhea RHEA:28379 assigns CHEBI:61393 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28379']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28378_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28378_compound_6448']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28379"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""RHEA:28379 directed fructoselysine catabolic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1901281_fructoselysine-edge-002_e2d410375007	CHEBI:30616	pathwaymech:consumes	RHEA:28379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28379		"[{""reference_id"": ""RHEA:28379"", ""source_assertion"": ""Rhea RHEA:28379 assigns CHEBI:30616 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28379']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28378_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28378_compound_6372']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28379"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""RHEA:28379 directed fructoselysine catabolic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1901281_fructoselysine-edge-003_4e6edf671eb3	RHEA:28379	pathwaymech:produces	CHEBI:61392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28379		"[{""reference_id"": ""RHEA:28379"", ""source_assertion"": ""Rhea RHEA:28379 assigns CHEBI:61392 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28379']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28378_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28378_compound_6447']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28379"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""RHEA:28379 directed fructoselysine catabolic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1901281_fructoselysine-edge-004_9e616bc5c498	RHEA:28379	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28379		"[{""reference_id"": ""RHEA:28379"", ""source_assertion"": ""Rhea RHEA:28379 assigns CHEBI:456216 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28379']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28378_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28378_compound_2710']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28379"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""RHEA:28379 directed fructoselysine catabolic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1901281_fructoselysine-edge-005_10013de4bad7	RHEA:28379	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28379		"[{""reference_id"": ""RHEA:28379"", ""source_assertion"": ""Rhea RHEA:28379 assigns CHEBI:15378 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28379']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28378_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28378_compound_3249']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28379"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""RHEA:28379 directed fructoselysine catabolic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1901281_fructoselysine-edge-006_e696b0b63f18	CHEBI:61392	pathwaymech:consumes	RHEA:28383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28383		"[{""reference_id"": ""RHEA:28383"", ""source_assertion"": ""Rhea RHEA:28383 assigns CHEBI:61392 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28383']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28382_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28382_compound_6447']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28383"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""RHEA:28383 directed fructoselysine catabolic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1901281_fructoselysine-edge-007_c0242dfc242d	CHEBI:15377	pathwaymech:consumes	RHEA:28383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28383		"[{""reference_id"": ""RHEA:28383"", ""source_assertion"": ""Rhea RHEA:28383 assigns CHEBI:15377 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28383']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28382_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28382_compound_1283']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28383"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""RHEA:28383 directed fructoselysine catabolic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1901281_fructoselysine-edge-008_1143f8e12599	RHEA:28383	pathwaymech:produces	CHEBI:61548	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28383		"[{""reference_id"": ""RHEA:28383"", ""source_assertion"": ""Rhea RHEA:28383 assigns CHEBI:61548 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28383']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28382_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28382_compound_6501']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28383"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""RHEA:28383 directed fructoselysine catabolic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1901281_fructoselysine-edge-009_5cf5bc555538	RHEA:28383	pathwaymech:produces	CHEBI:32551	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28383		"[{""reference_id"": ""RHEA:28383"", ""source_assertion"": ""Rhea RHEA:28383 assigns CHEBI:32551 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28383']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28382_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28382_compound_3235']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28383"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""RHEA:28383 directed fructoselysine catabolic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1901281_fructoselysine-edge-010_acd75dcd0f13	UniProtKB:P45543	pathwaymech:catalyzes	RHEA:28379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12147680|RHEA:28379|UniProtKB:P45543	FrlD supplies the ATP-dependent kinase activity; UniProt annotates it as monomeric.	"[{""reference_id"": ""UniProtKB:P45543"", ""source_assertion"": ""UniProt assigns FrlD (P45543, taxon 83333) catalytic activity for RHEA:28378, with experimental annotation ECO:0000269 from PMID:12147680."", ""source_locator"": ""primaryAccession; organism.taxonId; comments[commentType='CATALYTIC ACTIVITY'].reaction[reactionCrossReferences.id='RHEA:28378'].evidences""}, {""reference_id"": ""RHEA:28379"", ""source_assertion"": ""Rhea master RHEA:28378 has directional member RHEA:28379; its substrate/product assignments select the catabolic conversion represented here."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28378']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/28379']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28379']/rh:substrates and rh:products""}, {""quote"": ""ATP-dependent phosphorylation of fructoselysine"", ""reference_id"": ""PMID:12147680"", ""source_locator"": ""Europe PMC core resultList.result[id='12147680'].abstractText""}, {""reference_id"": ""UniProtKB:P45543"", ""source_assertion"": ""UniProt SUBUNIT annotates P45543 as Monomer, with ECO:0000269 from PMID:12147680."", ""source_locator"": ""comments[commentType='SUBUNIT'].texts""}]"	"[{""id"": ""PMID:12147680"", ""source_sha256"": ""16badcc75122a0180e43624a288a026fead55e9d21f5fe14290eeb718150b2ee"", ""source_version"": ""Europe PMC core metadata retrieved 2026-10-10"", ""title"": ""Identification of a pathway for the utilization of the Amadori product fructoselysine in Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12147680/""}, {""id"": ""RHEA:28379"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""RHEA:28379 directed fructoselysine catabolic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P45543"", ""source_sha256"": ""dfa557a2656ad36070beb24d892ae59c01bcdfafd24d0743c81ac87151e7d5ee"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P45543, Fructoselysine 6-kinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P45543.json""}]"	""
pathwaymech:GO_1901281_fructoselysine-edge-011_5c76862510c6	UniProtKB:P0AC00	pathwaymech:catalyzes	RHEA:28383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12147680|RHEA:28383|UniProtKB:P0AC00	FrlB supplies the deglycase activity and is annotated as homododecameric. The protein node denotes the gene product. The selected catabolic conversion also proceeds in reverse in vitro.	"[{""reference_id"": ""UniProtKB:P0AC00"", ""source_assertion"": ""UniProt assigns FrlB (P0AC00, taxon 83333) catalytic activity for RHEA:28382, with experimental annotation ECO:0000269 from PMID:12147680."", ""source_locator"": ""primaryAccession; organism.taxonId; comments[commentType='CATALYTIC ACTIVITY'].reaction[reactionCrossReferences.id='RHEA:28382'].evidences""}, {""reference_id"": ""RHEA:28383"", ""source_assertion"": ""Rhea master RHEA:28382 has directional member RHEA:28383; its substrate/product assignments select the catabolic conversion represented here."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28382']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/28383']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28383']/rh:substrates and rh:products""}, {""quote"": ""reversible conversion of fructoselysine 6-phosphate and water"", ""reference_id"": ""PMID:12147680"", ""source_locator"": ""Europe PMC core resultList.result[id='12147680'].abstractText""}, {""reference_id"": ""UniProtKB:P0AC00"", ""source_assertion"": ""UniProt SUBUNIT annotates P0AC00 as Homododecamer, with ECO:0000269 from PMID:12147680."", ""source_locator"": ""comments[commentType='SUBUNIT'].texts""}]"	"[{""id"": ""PMID:12147680"", ""source_sha256"": ""16badcc75122a0180e43624a288a026fead55e9d21f5fe14290eeb718150b2ee"", ""source_version"": ""Europe PMC core metadata retrieved 2026-10-10"", ""title"": ""Identification of a pathway for the utilization of the Amadori product fructoselysine in Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12147680/""}, {""id"": ""RHEA:28383"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""RHEA:28383 directed fructoselysine catabolic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0AC00"", ""source_sha256"": ""8a39f92fa00ac705a754a268a026765d25413c14d3bc0b5835aedf79a61ce49e"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P0AC00, Fructoselysine 6-phosphate deglycase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AC00.json""}]"	""
pathwaymech:GO_1901281_fructoselysine-edge-012_147160e633d4	RHEA:28379	BFO:0000050	GO:1901281	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:1901281|RHEA:28379|UniProtKB:P45543	The native UniPathway accession links the protein pathway assignment to the GO definition; the Rhea directional member supplies the reaction identity.	"[{""reference_id"": ""UniProtKB:P45543"", ""source_assertion"": ""UniProt assigns P45543 to fructoselysine degradation, D-glucose 6-phosphate and lysine from fructoselysine, step 1/2 (ECO:0000305); its UniPathway cross-reference is UPA00784/UER00769."", ""source_locator"": ""comments[commentType='PATHWAY'].texts; uniProtKBCrossReferences[database='UniPathway',id='UPA00784'].properties[key='RectionId']""}, {""reference_id"": ""RHEA:28379"", ""source_assertion"": ""Rhea master RHEA:28378 has directional member RHEA:28379; its substrate/product assignments select the catabolic conversion represented here."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28378']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/28379']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28379']/rh:substrates and rh:products""}, {""reference_id"": ""GO:1901281"", ""source_assertion"": ""QuickGO defines GO:1901281 as fructoselysine breakdown and gives UniPathway UPA00784 as the definition cross-reference."", ""source_locator"": ""results[id='GO:1901281'].definition.text and definition.xrefs[dbCode='UniPathway',dbId='UPA00784']""}]"	"[{""id"": ""GO:1901281"", ""source_sha256"": ""7593ef204917e5d650ed7e45571028d09bea41e768593723c57308b8629e5ab4"", ""source_version"": ""retrieved 2026-10-10"", ""title"": ""Gene Ontology fructoselysine catabolic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:1901281""}, {""id"": ""RHEA:28379"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""RHEA:28379 directed fructoselysine catabolic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P45543"", ""source_sha256"": ""dfa557a2656ad36070beb24d892ae59c01bcdfafd24d0743c81ac87151e7d5ee"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P45543, Fructoselysine 6-kinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P45543.json""}]"	""
pathwaymech:GO_1901281_fructoselysine-edge-013_594cd8545658	RHEA:28383	BFO:0000050	GO:1901281	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:1901281|RHEA:28383|UniProtKB:P0AC00	The native UniPathway accession links the protein pathway assignment to the GO definition; the Rhea directional member supplies the reaction identity.	"[{""reference_id"": ""UniProtKB:P0AC00"", ""source_assertion"": ""UniProt assigns P0AC00 to fructoselysine degradation, D-glucose 6-phosphate and lysine from fructoselysine, step 2/2 (ECO:0000269 and ECO:0000305); its UniPathway cross-reference is UPA00784/UER00770."", ""source_locator"": ""comments[commentType='PATHWAY'].texts; uniProtKBCrossReferences[database='UniPathway',id='UPA00784'].properties[key='RectionId']""}, {""reference_id"": ""RHEA:28383"", ""source_assertion"": ""Rhea master RHEA:28382 has directional member RHEA:28383; its substrate/product assignments select the catabolic conversion represented here."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28382']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/28383']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28383']/rh:substrates and rh:products""}, {""reference_id"": ""GO:1901281"", ""source_assertion"": ""QuickGO defines GO:1901281 as fructoselysine breakdown and gives UniPathway UPA00784 as the definition cross-reference."", ""source_locator"": ""results[id='GO:1901281'].definition.text and definition.xrefs[dbCode='UniPathway',dbId='UPA00784']""}]"	"[{""id"": ""GO:1901281"", ""source_sha256"": ""7593ef204917e5d650ed7e45571028d09bea41e768593723c57308b8629e5ab4"", ""source_version"": ""retrieved 2026-10-10"", ""title"": ""Gene Ontology fructoselysine catabolic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:1901281""}, {""id"": ""RHEA:28383"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""RHEA:28383 directed fructoselysine catabolic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0AC00"", ""source_sha256"": ""8a39f92fa00ac705a754a268a026765d25413c14d3bc0b5835aedf79a61ce49e"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P0AC00, Fructoselysine 6-phosphate deglycase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AC00.json""}]"	""
pathwaymech:GO_1901281_fructoselysine-edge-014_e759c7910219	RHEA:28379	pathwaymech:precedes	RHEA:28383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12147680|UniProtKB:P0AC00|UniProtKB:P45543	The kinase forms fructoselysine 6-phosphate, which is the deglycase substrate. Native pathway annotations specify steps 1/2 and 2/2.	"[{""reference_id"": ""UniProtKB:P45543"", ""source_assertion"": ""UniProt assigns P45543 to fructoselysine degradation, D-glucose 6-phosphate and lysine from fructoselysine, step 1/2 (ECO:0000305); its UniPathway cross-reference is UPA00784/UER00769."", ""source_locator"": ""comments[commentType='PATHWAY'].texts; uniProtKBCrossReferences[database='UniPathway',id='UPA00784'].properties[key='RectionId']""}, {""reference_id"": ""UniProtKB:P0AC00"", ""source_assertion"": ""UniProt assigns P0AC00 to fructoselysine degradation, D-glucose 6-phosphate and lysine from fructoselysine, step 2/2 (ECO:0000269 and ECO:0000305); its UniPathway cross-reference is UPA00784/UER00770."", ""source_locator"": ""comments[commentType='PATHWAY'].texts; uniProtKBCrossReferences[database='UniPathway',id='UPA00784'].properties[key='RectionId']""}, {""quote"": ""a delayed formation of glucose 6-phosphate"", ""reference_id"": ""PMID:12147680"", ""source_locator"": ""Europe PMC core resultList.result[id='12147680'].abstractText""}]"	"[{""id"": ""PMID:12147680"", ""source_sha256"": ""16badcc75122a0180e43624a288a026fead55e9d21f5fe14290eeb718150b2ee"", ""source_version"": ""Europe PMC core metadata retrieved 2026-10-10"", ""title"": ""Identification of a pathway for the utilization of the Amadori product fructoselysine in Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12147680/""}, {""id"": ""UniProtKB:P0AC00"", ""source_sha256"": ""8a39f92fa00ac705a754a268a026765d25413c14d3bc0b5835aedf79a61ce49e"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P0AC00, Fructoselysine 6-phosphate deglycase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AC00.json""}, {""id"": ""UniProtKB:P45543"", ""source_sha256"": ""dfa557a2656ad36070beb24d892ae59c01bcdfafd24d0743c81ac87151e7d5ee"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P45543, Fructoselysine 6-kinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P45543.json""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-001_637e9b1f97c5	gomodel:UDPGLUCEPIM-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:UDPGLUCEPIM-RXN BFO:0000066 gomodel:reaction_UDPGLUCEPIM-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/0; endpoint types: /individuals/14/type; /individuals/47/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-002_b5a1dc5f2015	gomodel:GALACTURIDYLYLTRANS-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GALACTURIDYLYLTRANS-RXN BFO:0000066 gomodel:reaction_GALACTURIDYLYLTRANS-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/1; endpoint types: /individuals/12/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-003_d93a14445f0b	gomodel:PHOSPHOGLUCMUT-RXN	RO:0002234	CHEBI:4170	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOGLUCMUT-RXN RO:0002234 gomodel:CHEBI_4170_PHOSPHOGLUCMUT-RXN."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/2; endpoint types: /individuals/13/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-004_95bcdccd96fa	SGD:S000004711	pathwaymech:enables	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632 RO:0002333 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000634."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/3; endpoint types: /individuals/49/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-005_8aac2e1ed919	gomodel:GALACTOKIN-RXN	BFO:0000050	GO:0019388	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GALACTOKIN-RXN BFO:0000050 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/YeastPathways_YEAST-GALACT-METAB-PWY."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/4; endpoint types: /individuals/11/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-006_aa7bd9cd77c9	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632	RO:0002233	CHEBI:58601	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632 RO:0002233 gomodel:CHEBI_58601_GALACTURIDYLYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/5; endpoint types: /individuals/49/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-007_994d313fe097	gomodel:PHOSPHOGLUCMUT-RXN	RO:0002233	CHEBI:58601	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOGLUCMUT-RXN RO:0002233 gomodel:CHEBI_58601_GALACTURIDYLYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/6; endpoint types: /individuals/13/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-008_879f4b8ffcc5	gomodel:UDPGLUCEPIM-RXN	RO:0002234	CHEBI:58885	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:UDPGLUCEPIM-RXN RO:0002234 gomodel:CHEBI_58885_UDPGLUCEPIM-RXN."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/7; endpoint types: /individuals/14/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-009_565a18dd44a8	gomodel:UDPGLUCEPIM-RXN	BFO:0000050	GO:0019388	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:UDPGLUCEPIM-RXN BFO:0000050 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/YeastPathways_YEAST-GALACT-METAB-PWY."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/8; endpoint types: /individuals/14/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-010_97f15d8a92cf	gomodel:GALACTOKIN-RXN	RO:0002234	CHEBI:58336	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GALACTOKIN-RXN RO:0002234 gomodel:CHEBI_58336_GALACTOKIN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/9; endpoint types: /individuals/11/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-011_e9095d116468	gomodel:ALDOSE1EPIM-RXN	BFO:0000050	GO:0019388	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:ALDOSE1EPIM-RXN BFO:0000050 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/YeastPathways_YEAST-GALACT-METAB-PWY."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/10; endpoint types: /individuals/0/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-012_8d93be69e156	gomodel:GALACTOKIN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GALACTOKIN-RXN RO:0002234 gomodel:CHEBI_15378_GALACTOKIN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/11; endpoint types: /individuals/11/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-013_f78050cec24e	SGD:S000000223	pathwaymech:enables	gomodel:ALDOSE1EPIM-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:ALDOSE1EPIM-RXN RO:0002333 gomodel:YBR019C-MONOMER_ALDOSE1EPIM-RXN_controller."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/12; endpoint types: /individuals/0/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-014_795d7c5de8d3	SGD:S000000224	pathwaymech:enables	gomodel:GALACTOKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GALACTOKIN-RXN RO:0002333 gomodel:YBR020W-MONOMER_GALACTOKIN-RXN_controller."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/13; endpoint types: /individuals/11/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-015_32ffabb4e428	gomodel:PHOSPHOGLUCMUT-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOGLUCMUT-RXN BFO:0000066 gomodel:reaction_PHOSPHOGLUCMUT-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/14; endpoint types: /individuals/13/type; /individuals/46/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-016_bea3b66eb9e2	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632	RO:0002234	CHEBI:4170	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632 RO:0002234 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000633."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/15; endpoint types: /individuals/49/type; /individuals/50/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-017_2cc468b17f55	gomodel:GALACTOKIN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GALACTOKIN-RXN BFO:0000066 gomodel:reaction_GALACTOKIN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/16; endpoint types: /individuals/11/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-018_7aced6ebcb0c	gomodel:ALDOSE1EPIM-RXN	RO:0002234	CHEBI:28061	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:ALDOSE1EPIM-RXN RO:0002234 gomodel:CHEBI_28061_ALDOSE1EPIM-RXN."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/17; endpoint types: /individuals/0/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-019_a1b2215b9db9	gomodel:GALACTOKIN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GALACTOKIN-RXN RO:0002233 gomodel:CHEBI_30616_GALACTOKIN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/18; endpoint types: /individuals/11/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-020_6db93ed85923	SGD:S000000222	pathwaymech:enables	gomodel:GALACTURIDYLYLTRANS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GALACTURIDYLYLTRANS-RXN RO:0002333 gomodel:YBR018C-MONOMER_GALACTURIDYLYLTRANS-RXN_controller."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/19; endpoint types: /individuals/12/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-021_d51582e63907	gomodel:GALACTURIDYLYLTRANS-RXN	RO:0002234	CHEBI:58601	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GALACTURIDYLYLTRANS-RXN RO:0002234 gomodel:CHEBI_58601_GALACTURIDYLYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/20; endpoint types: /individuals/12/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-022_4c815986af3c	SGD:S000001610	pathwaymech:enables	gomodel:PHOSPHOGLUCMUT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOGLUCMUT-RXN RO:0002333 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6690711d00000510."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/21; endpoint types: /individuals/13/type; /individuals/58/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-023_e831138f85a9	gomodel:ALDOSE1EPIM-RXN	RO:0002233	CHEBI:27667	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:ALDOSE1EPIM-RXN RO:0002233 gomodel:CHEBI_27667_ALDOSE1EPIM-RXN."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/22; endpoint types: /individuals/0/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-024_8ab77e44e863	gomodel:GALACTURIDYLYLTRANS-RXN	RO:0002233	CHEBI:58336	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GALACTURIDYLYLTRANS-RXN RO:0002233 gomodel:CHEBI_58336_GALACTOKIN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/23; endpoint types: /individuals/12/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-025_18bf9ab96c36	gomodel:GALACTURIDYLYLTRANS-RXN	RO:0002234	CHEBI:66914	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GALACTURIDYLYLTRANS-RXN RO:0002234 gomodel:CHEBI_66914_GALACTURIDYLYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/24; endpoint types: /individuals/12/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-026_8de623a91259	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632	BFO:0000050	GO:0019388	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632 BFO:0000050 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/YeastPathways_YEAST-GALACT-METAB-PWY."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/25; endpoint types: /individuals/49/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-027_8a149a68527e	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632 BFO:0000066 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000636."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/26; endpoint types: /individuals/49/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-028_1be3c4e906db	gomodel:GALACTOKIN-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GALACTOKIN-RXN RO:0002234 gomodel:CHEBI_456216_GALACTOKIN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/27; endpoint types: /individuals/11/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-029_a297502d9fc8	gomodel:GALACTURIDYLYLTRANS-RXN	BFO:0000050	GO:0019388	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GALACTURIDYLYLTRANS-RXN BFO:0000050 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/YeastPathways_YEAST-GALACT-METAB-PWY."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/28; endpoint types: /individuals/12/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-030_dda914a0364e	gomodel:PHOSPHOGLUCMUT-RXN	BFO:0000050	GO:0019388	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOGLUCMUT-RXN BFO:0000050 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/YeastPathways_YEAST-GALACT-METAB-PWY."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/29; endpoint types: /individuals/13/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-031_f8f03badfef2	gomodel:UDPGLUCEPIM-RXN	RO:0002233	CHEBI:66914	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:UDPGLUCEPIM-RXN RO:0002233 gomodel:CHEBI_66914_GALACTURIDYLYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/30; endpoint types: /individuals/14/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-032_683dc33b96fa	gomodel:ALDOSE1EPIM-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:ALDOSE1EPIM-RXN BFO:0000066 gomodel:reaction_ALDOSE1EPIM-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/31; endpoint types: /individuals/0/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-033_979e88042273	SGD:S000000223	pathwaymech:enables	gomodel:UDPGLUCEPIM-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:UDPGLUCEPIM-RXN RO:0002333 gomodel:YBR019C-MONOMER_UDPGLUCEPIM-RXN_controller."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/32; endpoint types: /individuals/14/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-034_9b1ee59f037b	gomodel:GALACTOKIN-RXN	RO:0002233	CHEBI:28061	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GALACTOKIN-RXN RO:0002233 gomodel:CHEBI_28061_ALDOSE1EPIM-RXN."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/33; endpoint types: /individuals/11/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_edge-035_5c5372532603	gomodel:GALACTURIDYLYLTRANS-RXN	RO:0002233	CHEBI:58885	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_assertion"": ""The model asserts gomodel:GALACTURIDYLYLTRANS-RXN RO:0002233 gomodel:CHEBI_58885_UDPGLUCEPIM-RXN."", ""source_locator"": ""./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/34; endpoint types: /individuals/12/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-GALACT-METAB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json"", ""title"": ""SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_location-bdb7eec3df16_2a8b45e19aa9	SGD:S000004711	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37012	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:8385141)	"[{""reference_id"": ""UniProtKB:P37012"", ""source_assertion"": ""UniProtKB:P37012 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1251/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P37012"", ""source_assertion"": ""UniProtKB:P37012 has the exact SGD cross-reference SGD:S000004711."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1251/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P37012"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P37012 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_location-f282e8da1094_6815cf5ffd2b	SGD:S000001610	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33401	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P33401"", ""source_assertion"": ""UniProtKB:P33401 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1085/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P33401"", ""source_assertion"": ""UniProtKB:P33401 has the exact SGD cross-reference SGD:S000001610."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1085/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P33401"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P33401 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_cofactor-0945beb9b2eb_cd750f75793e	SGD:S000004711	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37012	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805) Binds 1 magnesium ion per subunit. Can also use Zn(2+) as cofactor. UniProt note evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805)	"[{""reference_id"": ""UniProtKB:P37012"", ""source_assertion"": ""UniProtKB:P37012 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/comments/0/cofactors/0; /results/1251/comments/0/note""}, {""reference_id"": ""UniProtKB:P37012"", ""source_assertion"": ""UniProtKB:P37012 has the exact SGD cross-reference SGD:S000004711."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P37012"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P37012 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_cofactor-02ad2260b7d9_ac63e9d009c7	SGD:S000004711	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37012	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805) Binds 1 magnesium ion per subunit. Can also use Zn(2+) as cofactor. UniProt note evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805)	"[{""reference_id"": ""UniProtKB:P37012"", ""source_assertion"": ""UniProtKB:P37012 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/comments/0/cofactors/1; /results/1251/comments/0/note""}, {""reference_id"": ""UniProtKB:P37012"", ""source_assertion"": ""UniProtKB:P37012 has the exact SGD cross-reference SGD:S000004711."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P37012"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P37012 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_cofactor-890051017cf2_7e74954b3d56	SGD:S000000223	pathwaymech:has_cofactor	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P04397	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P04397"", ""source_assertion"": ""UniProtKB:P04397 annotates CHEBI:57540 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/84/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P04397"", ""source_assertion"": ""UniProtKB:P04397 has the exact SGD cross-reference SGD:S000000223."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/84/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P04397"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P04397 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_cofactor-3a91301be9d8_602830affe92	SGD:S000000222	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08431	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P09148) Binds 1 zinc ion per subunit. Zinc binding seems to play a structural role. UniProt note evidence: ECO:0000250 (UniProtKB:P09148)	"[{""reference_id"": ""UniProtKB:P08431"", ""source_assertion"": ""UniProtKB:P08431 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3254/comments/0/cofactors/0; /results/3254/comments/0/note""}, {""reference_id"": ""UniProtKB:P08431"", ""source_assertion"": ""UniProtKB:P08431 has the exact SGD cross-reference SGD:S000000222."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3254/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P08431"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P08431 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-GALACT-METAB-PWY_cofactor-ad9ff5447ab5_06082af500b1	SGD:S000001610	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33401	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00949) Binds 1 Mg(2+) ion per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00949)	"[{""reference_id"": ""UniProtKB:P33401"", ""source_assertion"": ""UniProtKB:P33401 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1085/comments/0/cofactors/0; /results/1085/comments/0/note""}, {""reference_id"": ""UniProtKB:P33401"", ""source_assertion"": ""UniProtKB:P33401 has the exact SGD cross-reference SGD:S000001610."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1085/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P33401"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P33401 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-001_92e1fe5f6356	gomodel:1.1.1.39-RXN	RO:0002413	gomodel:PYRUVATE-CARBOXYLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36013|gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:1.1.1.39-RXN RO:0002413 gomodel:PYRUVATE-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/0; endpoint types: /individuals/132/type; /individuals/44/type""}, {""reference_id"": ""UniProtKB:P36013"", ""source_assertion"": ""UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P36013"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36013 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-002_404800b5eb60	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125	RO:0002233	CHEBI:58702	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125 RO:0002233 gomodel:CHEBI_58702_PEPCARBOXYKIN-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/1; endpoint types: /individuals/167/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-003_c39f99be56d8	gomodel:PYRUVATE-CARBOXYLASE-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002233 gomodel:CHEBI_30616_PYRUVATE-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/2; endpoint types: /individuals/44/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-004_4dc56c581112	gomodel:F16BDEPHOS-RXN	RO:0002413	gomodel:PGLUCISOM-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:F16BDEPHOS-RXN RO:0002413 gomodel:PGLUCISOM-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/3; endpoint types: /individuals/38/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-005_510233dd9b88	gomodel:PHOSGLYPHOS-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002233 gomodel:CHEBI_30616_PHOSGLYPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/4; endpoint types: /individuals/43/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-006_c87d43fd4216	gomodel:PGLUCISOM-RXN	RO:0002234	CHEBI:4170	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PGLUCISOM-RXN RO:0002234 gomodel:CHEBI_4170_PGLUCISOM-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/5; endpoint types: /individuals/42/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-007_8d688cb2331b	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158	RO:0002233	CHEBI:57604	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 RO:0002233 gomodel:CHEBI_57604_PHOSGLYPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/6; endpoint types: /individuals/197/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-008_636ded76b829	gomodel:MALATE-DEH-RXN	RO:0002234	CHEBI:16452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:MALATE-DEH-RXN RO:0002234 gomodel:CHEBI_16452_MALATE-DEH-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/7; endpoint types: /individuals/40/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-009_567f045c6247	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 RO:0002234 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005141."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/8; endpoint types: /individuals/179/type; /individuals/182/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-010_b18f7aa7d156	gomodel:PEPCARBOXYKIN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PEPCARBOXYKIN-RXN BFO:0000066 gomodel:reaction_PEPCARBOXYKIN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/9; endpoint types: /individuals/41/type; /individuals/127/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-011_099d4e5fc647	gomodel:GAPOXNPHOSPHN-RXN	RO:0002234	CHEBI:59776	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002234 gomodel:CHEBI_59776_GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/10; endpoint types: /individuals/39/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-013_0a10e75fc055	gomodel:PEPCARBOXYKIN-RXN	BFO:0000050	GO:0006094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PEPCARBOXYKIN-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/12; endpoint types: /individuals/41/type; /individuals/134/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-014_53ed3a93c084	gomodel:F16ALDOLASE-RXN	RO:0002233	CHEBI:57642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:F16ALDOLASE-RXN RO:0002233 gomodel:CHEBI_57642_F16ALDOLASE-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/13; endpoint types: /individuals/37/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-015_99ea0f422b3e	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125 BFO:0000066 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005129."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/14; endpoint types: /individuals/167/type; /individuals/170/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-016_64402123968d	gomodel:F16BDEPHOS-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:F16BDEPHOS-RXN BFO:0000066 gomodel:reaction_F16BDEPHOS-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/15; endpoint types: /individuals/38/type; /individuals/124/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-017_151e82ac0946	gomodel:PGLUCISOM-RXN	RO:0002233	CHEBI:57634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PGLUCISOM-RXN RO:0002233 gomodel:CHEBI_57634_F16BDEPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/16; endpoint types: /individuals/42/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-018_2a35cc73e4a8	gomodel:PEPCARBOXYKIN-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PEPCARBOXYKIN-RXN RO:0002234 gomodel:CHEBI_16526_PEPCARBOXYKIN-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/17; endpoint types: /individuals/41/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-019_f1ab2ab248bb	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 BFO:0000066 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005112."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/18; endpoint types: /individuals/146/type; /individuals/154/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-020_9cdfe4d9df34	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138	RO:0002413	gomodel:F16ALDOLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 RO:0002413 gomodel:F16ALDOLASE-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/19; endpoint types: /individuals/179/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-021_bbb032a75614	gomodel:F16BDEPHOS-RXN	RO:0002233	CHEBI:32966	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:F16BDEPHOS-RXN RO:0002233 gomodel:CHEBI_32966_F16ALDOLASE-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/20; endpoint types: /individuals/38/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-022_527e4845dc82	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125	BFO:0000050	GO:0006094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125 BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/21; endpoint types: /individuals/167/type; /individuals/134/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-023_c26060b37353	gomodel:2PGADEHYDRAT-RXN	RO:0002413	gomodel:RXN-15513	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2PGADEHYDRAT-RXN RO:0002413 gomodel:RXN-15513."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/22; endpoint types: /individuals/133/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-024_2ac83e23f063	gomodel:2PGADEHYDRAT-RXN	BFO:0000050	GO:0006094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2PGADEHYDRAT-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/23; endpoint types: /individuals/133/type; /individuals/134/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-025_e679d5d3ec34	gomodel:GAPOXNPHOSPHN-RXN	RO:0002413	gomodel:F16ALDOLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002413 gomodel:F16ALDOLASE-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/24; endpoint types: /individuals/39/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-027_ef84538e17c6	gomodel:F16ALDOLASE-RXN	RO:0002233	CHEBI:59776	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:F16ALDOLASE-RXN RO:0002233 gomodel:CHEBI_59776_GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/26; endpoint types: /individuals/37/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-028_072a211ff50c	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138	RO:0002234	CHEBI:59776	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 RO:0002234 gomodel:CHEBI_59776_GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/27; endpoint types: /individuals/179/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-029_08806ac45110	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 RO:0002234 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005162."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/28; endpoint types: /individuals/197/type; /individuals/201/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-030_52c96f5edbef	gomodel:2PGADEHYDRAT-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2PGADEHYDRAT-RXN BFO:0000066 gomodel:reaction_2PGADEHYDRAT-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/29; endpoint types: /individuals/133/type; /individuals/122/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-031_7dd338644b66	gomodel:GAPOXNPHOSPHN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN BFO:0000066 gomodel:reaction_GAPOXNPHOSPHN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/30; endpoint types: /individuals/39/type; /individuals/125/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-032_469c4d2b74fd	gomodel:PHOSGLYPHOS-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002234 gomodel:CHEBI_456216_PHOSGLYPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/31; endpoint types: /individuals/43/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-033_b75bd9e0d437	SGD:S000001635	pathwaymech:enables	gomodel:RXN-15513	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN-15513 RO:0002333 gomodel:YKL152C-MONOMER_RXN-15513_controller."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/32; endpoint types: /individuals/45/type; /individuals/53/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-034_1a6245a4c511	gomodel:2PGADEHYDRAT-RXN	RO:0002234	CHEBI:58289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2PGADEHYDRAT-RXN RO:0002234 gomodel:CHEBI_58289_2PGADEHYDRAT-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/33; endpoint types: /individuals/133/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-035_ca1ad94a28e9	gomodel:PYRUVATE-CARBOXYLASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_15378_PYRUVATE-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/34; endpoint types: /individuals/44/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-036_08a9e3243535	gomodel:F16BDEPHOS-RXN	BFO:0000050	GO:0006094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:F16BDEPHOS-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/35; endpoint types: /individuals/38/type; /individuals/134/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-037_d68d746685ea	gomodel:1.1.1.39-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36013|gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:1.1.1.39-RXN RO:0002234 gomodel:CHEBI_16526_1.1.1.39-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/36; endpoint types: /individuals/132/type; /individuals/10/type""}, {""reference_id"": ""UniProtKB:P36013"", ""source_assertion"": ""UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P36013"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36013 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-038_6ac5bb433a5f	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 RO:0002234 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005106."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/37; endpoint types: /individuals/146/type; /individuals/149/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-039_79e18e899e13	gomodel:PYRUVATE-CARBOXYLASE-RXN	RO:0002413	gomodel:PEPCARBOXYKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002413 gomodel:PEPCARBOXYKIN-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/38; endpoint types: /individuals/44/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-040_00c935642d25	gomodel:F16ALDOLASE-RXN	RO:0002234	CHEBI:32966	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:F16ALDOLASE-RXN RO:0002234 gomodel:CHEBI_32966_F16ALDOLASE-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/39; endpoint types: /individuals/37/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-041_14f94575cbc1	gomodel:MALATE-DEH-RXN	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:MALATE-DEH-RXN RO:0002233 gomodel:CHEBI_57540_MALATE-DEH-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/40; endpoint types: /individuals/40/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-042_4682b997aeac	gomodel:PEPCARBOXYKIN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PEPCARBOXYKIN-RXN RO:0002233 gomodel:CHEBI_30616_PEPCARBOXYKIN-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/41; endpoint types: /individuals/41/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-043_61387fdabd5f	gomodel:2PGADEHYDRAT-RXN	RO:0002233	CHEBI:58702	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2PGADEHYDRAT-RXN RO:0002233 gomodel:CHEBI_58702_PEPCARBOXYKIN-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/42; endpoint types: /individuals/133/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-044_0d2b33b22d4a	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 BFO:0000066 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005146."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/43; endpoint types: /individuals/179/type; /individuals/185/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-045_d3e22c86936c	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103	RO:0002233	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 RO:0002233 gomodel:CHEBI_15361_1.1.1.39-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/44; endpoint types: /individuals/146/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-046_30ce78edf66c	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 RO:0002233 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005140."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/45; endpoint types: /individuals/179/type; /individuals/181/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-047_c0aac9a3586b	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103	RO:0002233	CHEBI:17544	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 RO:0002233 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005105."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/46; endpoint types: /individuals/146/type; /individuals/148/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-048_b5de46a0afb8	gomodel:PEPCARBOXYKIN-RXN	RO:0002413	gomodel:2PGADEHYDRAT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PEPCARBOXYKIN-RXN RO:0002413 gomodel:2PGADEHYDRAT-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/47; endpoint types: /individuals/41/type; /individuals/133/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-049_c8c14a215466	gomodel:PGLUCISOM-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PGLUCISOM-RXN BFO:0000066 gomodel:reaction_PGLUCISOM-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/48; endpoint types: /individuals/42/type; /individuals/128/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-050_5adf9d57640e	gomodel:PGLUCISOM-RXN	BFO:0000050	GO:0006094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PGLUCISOM-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/49; endpoint types: /individuals/42/type; /individuals/134/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-051_12b5a450dec2	gomodel:MALATE-DEH-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:MALATE-DEH-RXN RO:0002234 gomodel:CHEBI_15378_MALATE-DEH-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/50; endpoint types: /individuals/40/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-052_8391dedaaad0	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 RO:0002234 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005142."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/51; endpoint types: /individuals/179/type; /individuals/183/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-053_f9b8395ea67d	gomodel:GAPOXNPHOSPHN-RXN	BFO:0000050	GO:0006094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/52; endpoint types: /individuals/39/type; /individuals/134/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-055_87e543b2852e	gomodel:PYRUVATE-CARBOXYLASE-RXN	BFO:0000050	GO:0006094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/54; endpoint types: /individuals/44/type; /individuals/134/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-057_4720c40d55f5	gomodel:1.1.1.39-RXN	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36013|gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:1.1.1.39-RXN RO:0002233 gomodel:CHEBI_57540_1.1.1.39-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/56; endpoint types: /individuals/132/type; /individuals/24/type""}, {""reference_id"": ""UniProtKB:P36013"", ""source_assertion"": ""UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P36013"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36013 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-058_fd2c9d734e82	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125	RO:0002234	CHEBI:58289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125 RO:0002234 gomodel:CHEBI_58289_2PGADEHYDRAT-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/57; endpoint types: /individuals/167/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-059_b26648087167	SGD:S000001512	pathwaymech:enables	gomodel:1.1.1.39-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36013|gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:1.1.1.39-RXN RO:0002333 gomodel:YKL029C-MONOMER_1.1.1.39-RXN_controller."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/58; endpoint types: /individuals/132/type; /individuals/51/type""}, {""reference_id"": ""UniProtKB:P36013"", ""source_assertion"": ""UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P36013"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36013 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-060_8d82d036c7db	gomodel:MALATE-DEH-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:MALATE-DEH-RXN BFO:0000066 gomodel:reaction_MALATE-DEH-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/59; endpoint types: /individuals/40/type; /individuals/126/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-061_baacbcf2374a	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125 RO:0002233 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005126."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/60; endpoint types: /individuals/167/type; /individuals/168/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-062_13ddd7163718	SGD:S000003424	pathwaymech:enables	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 RO:0002333 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005163."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/61; endpoint types: /individuals/197/type; /individuals/202/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-063_07a2f69aef89	gomodel:1.1.1.39-RXN	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36013|gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:1.1.1.39-RXN RO:0002234 gomodel:CHEBI_57945_1.1.1.39-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/62; endpoint types: /individuals/132/type; /individuals/30/type""}, {""reference_id"": ""UniProtKB:P36013"", ""source_assertion"": ""UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P36013"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36013 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-064_ac4f455b70b2	gomodel:RXN-15513	BFO:0000050	GO:0006094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN-15513 BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/63; endpoint types: /individuals/45/type; /individuals/134/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-065_25086b703c18	SGD:S000000605	pathwaymech:enables	gomodel:PHOSGLYPHOS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002333 gomodel:YCR012W-MONOMER_PHOSGLYPHOS-RXN_controller."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/64; endpoint types: /individuals/43/type; /individuals/47/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-066_73beb515f0aa	gomodel:PYRUVATE-CARBOXYLASE-RXN	RO:0002233	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002233 gomodel:CHEBI_15361_1.1.1.39-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/65; endpoint types: /individuals/44/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-067_c0001c151ba2	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 RO:0002233 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005139."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/66; endpoint types: /individuals/179/type; /individuals/180/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-068_f220bddb68c4	SGD:S000005486	pathwaymech:enables	gomodel:MALATE-DEH-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:MALATE-DEH-RXN RO:0002333 gomodel:YeastPathways_GLUCONEO-PWY-1/6690711d00001653."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/67; endpoint types: /individuals/40/type; /individuals/217/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-069_f85967dc4b99	gomodel:RXN-15513	RO:0002413	gomodel:PHOSGLYPHOS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN-15513 RO:0002413 gomodel:PHOSGLYPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/68; endpoint types: /individuals/45/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-070_d9930cde35c2	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 BFO:0000066 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005165."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/69; endpoint types: /individuals/197/type; /individuals/203/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-072_04923059ca32	gomodel:GAPOXNPHOSPHN-RXN	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002233 gomodel:CHEBI_57945_GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/71; endpoint types: /individuals/39/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-073_1fbee409c269	gomodel:F16BDEPHOS-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:F16BDEPHOS-RXN RO:0002234 gomodel:CHEBI_43474_F16BDEPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/72; endpoint types: /individuals/38/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-074_d73998f32aed	gomodel:GAPOXNPHOSPHN-RXN	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002234 gomodel:CHEBI_57540_GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/73; endpoint types: /individuals/39/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-075_4540b34004cd	gomodel:MALATE-DEH-RXN	BFO:0000050	GO:0006094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:MALATE-DEH-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/74; endpoint types: /individuals/40/type; /individuals/134/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-076_5a1a176fc603	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103	RO:0002413	gomodel:PEPCARBOXYKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 RO:0002413 gomodel:PEPCARBOXYKIN-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/75; endpoint types: /individuals/146/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-077_54f2244d599a	gomodel:F16ALDOLASE-RXN	BFO:0000050	GO:0006094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:F16ALDOLASE-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/76; endpoint types: /individuals/37/type; /individuals/134/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-078_c38aa2d57a59	SGD:S000001217	pathwaymech:enables	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125 RO:0002333 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005127."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/77; endpoint types: /individuals/167/type; /individuals/169/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-079_d7121071683c	gomodel:F16BDEPHOS-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:F16BDEPHOS-RXN RO:0002233 gomodel:CHEBI_15377_F16BDEPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/78; endpoint types: /individuals/38/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-080_116532fb6f60	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 RO:0002234 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005161."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/79; endpoint types: /individuals/197/type; /individuals/200/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-081_994fdac687ff	gomodel:2PGADEHYDRAT-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2PGADEHYDRAT-RXN RO:0002233 gomodel:CHEBI_15377_2PGADEHYDRAT-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/80; endpoint types: /individuals/133/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-082_189867874acc	SGD:S000001805	pathwaymech:enables	gomodel:PEPCARBOXYKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PEPCARBOXYKIN-RXN RO:0002333 gomodel:YKR097W-MONOMER_PEPCARBOXYKIN-RXN_controller."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/81; endpoint types: /individuals/41/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-084_476759f3c7e8	gomodel:PHOSGLYPHOS-RXN	RO:0002234	CHEBI:57604	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002234 gomodel:CHEBI_57604_PHOSGLYPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/83; endpoint types: /individuals/43/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-085_c5cdb5a8f4dc	gomodel:1.1.1.39-RXN	BFO:0000066	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36013|gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:1.1.1.39-RXN BFO:0000066 gomodel:YeastPathways_GLUCONEO-PWY-1/6690711d00001647."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/84; endpoint types: /individuals/132/type; /individuals/215/type""}, {""reference_id"": ""UniProtKB:P36013"", ""source_assertion"": ""UniProtKB:P36013 describes the corresponding catalytic function in the mitochondrion; this projection applies to the activity enabled by SGD:S000001512."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3501/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P36013"", ""source_assertion"": ""UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P36013"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36013 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-086_c4621ecb679c	gomodel:F16ALDOLASE-RXN	RO:0002413	gomodel:F16BDEPHOS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:F16ALDOLASE-RXN RO:0002413 gomodel:F16BDEPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/85; endpoint types: /individuals/37/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-087_718887318313	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103	RO:0002234	CHEBI:16452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 RO:0002234 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005108."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/86; endpoint types: /individuals/146/type; /individuals/151/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-088_68463bb1e8e1	gomodel:PYRUVATE-CARBOXYLASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN BFO:0000066 gomodel:reaction_PYRUVATE-CARBOXYLASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/87; endpoint types: /individuals/44/type; /individuals/130/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-089_f068b87e365e	gomodel:GAPOXNPHOSPHN-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002234 gomodel:CHEBI_43474_GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/88; endpoint types: /individuals/39/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-091_cbe426ff81f4	gomodel:1.1.1.39-RXN	BFO:0000050	GO:0006094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36013|gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:1.1.1.39-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/90; endpoint types: /individuals/132/type; /individuals/134/type""}, {""reference_id"": ""UniProtKB:P36013"", ""source_assertion"": ""UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P36013"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36013 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-092_198bd09e7143	gomodel:GAPOXNPHOSPHN-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002233 gomodel:CHEBI_15378_GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/91; endpoint types: /individuals/39/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-093_73cb0c159619	gomodel:RXN-15513	RO:0002233	CHEBI:58289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN-15513 RO:0002233 gomodel:CHEBI_58289_2PGADEHYDRAT-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/92; endpoint types: /individuals/45/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-094_002b157115f9	SGD:S000004369	pathwaymech:enables	gomodel:F16BDEPHOS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:F16BDEPHOS-RXN RO:0002333 gomodel:YLR377C-MONOMER_F16BDEPHOS-RXN_controller."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/93; endpoint types: /individuals/38/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-095_59289bd51f73	gomodel:RXN-15513	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN-15513 BFO:0000066 gomodel:reaction_RXN-15513_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/94; endpoint types: /individuals/45/type; /individuals/131/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-096_89829f72b792	gomodel:GAPOXNPHOSPHN-RXN	RO:0002233	CHEBI:57604	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002233 gomodel:CHEBI_57604_PHOSGLYPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/95; endpoint types: /individuals/39/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-098_6070f7064a6b	gomodel:PEPCARBOXYKIN-RXN	RO:0002233	CHEBI:16452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PEPCARBOXYKIN-RXN RO:0002233 gomodel:CHEBI_16452_MALATE-DEH-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/97; endpoint types: /individuals/41/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-099_4ca8e7e7c688	SGD:S000003486	pathwaymech:enables	gomodel:2PGADEHYDRAT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2PGADEHYDRAT-RXN RO:0002333 gomodel:YGR254W-MONOMER_2PGADEHYDRAT-RXN_controller."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/98; endpoint types: /individuals/133/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-100_6e3729433b21	SGD:S000000422	pathwaymech:enables	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 RO:0002333 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005110."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/99; endpoint types: /individuals/146/type; /individuals/153/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-101_23075abd223b	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 RO:0002234 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005109."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/100; endpoint types: /individuals/146/type; /individuals/152/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-102_d1472c6bb6bc	gomodel:MALATE-DEH-RXN	RO:0002233	CHEBI:15589	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:MALATE-DEH-RXN RO:0002233 gomodel:CHEBI_15589_MALATE-DEH-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/101; endpoint types: /individuals/40/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-103_c39ee7cf9d4e	SGD:S000003030	pathwaymech:enables	gomodel:PYRUVATE-CARBOXYLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002333 gomodel:YGL062W-MONOMER_PYRUVATE-CARBOXYLASE-RXN_controller."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/102; endpoint types: /individuals/44/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-104_6de28ba00dd8	gomodel:PEPCARBOXYKIN-RXN	RO:0002413	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PEPCARBOXYKIN-RXN RO:0002413 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/103; endpoint types: /individuals/41/type; /individuals/167/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-105_33e37c88f4b7	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 RO:0002233 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005104."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/104; endpoint types: /individuals/146/type; /individuals/147/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-106_5a0ef0b979f0	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158	RO:0002234	CHEBI:59776	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 RO:0002234 gomodel:CHEBI_59776_GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/105; endpoint types: /individuals/197/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-108_5a270fcd1885	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158	RO:0002413	gomodel:F16ALDOLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 RO:0002413 gomodel:F16ALDOLASE-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/107; endpoint types: /individuals/197/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-109_d5ad21dfa3d3	gomodel:PYRUVATE-CARBOXYLASE-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_43474_PYRUVATE-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/108; endpoint types: /individuals/44/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-110_78c8daccc388	gomodel:PYRUVATE-CARBOXYLASE-RXN	RO:0002234	CHEBI:16452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_16452_PYRUVATE-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/109; endpoint types: /individuals/44/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-111_5d6ebe4f72ad	gomodel:PHOSGLYPHOS-RXN	RO:0002413	gomodel:GAPOXNPHOSPHN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002413 gomodel:GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/110; endpoint types: /individuals/43/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-112_c86fc8974664	gomodel:MALATE-DEH-RXN	RO:0002413	gomodel:PEPCARBOXYKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:MALATE-DEH-RXN RO:0002413 gomodel:PEPCARBOXYKIN-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/111; endpoint types: /individuals/40/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-113_3e1e2f850995	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138	BFO:0000050	GO:0006094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/112; endpoint types: /individuals/179/type; /individuals/134/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-114_620b8d703e75	gomodel:F16ALDOLASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:F16ALDOLASE-RXN BFO:0000066 gomodel:reaction_F16ALDOLASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/113; endpoint types: /individuals/37/type; /individuals/123/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-115_ca7ef7f0aa3d	gomodel:PYRUVATE-CARBOXYLASE-RXN	RO:0002233	CHEBI:17544	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002233 gomodel:CHEBI_17544_PYRUVATE-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/114; endpoint types: /individuals/44/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-116_5babb0bdb941	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138	RO:0002233	CHEBI:57604	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 RO:0002233 gomodel:CHEBI_57604_PHOSGLYPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/115; endpoint types: /individuals/179/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-117_8b831997ee4a	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 RO:0002233 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005160."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/116; endpoint types: /individuals/197/type; /individuals/199/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-118_ecf9858eb4fb	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 RO:0002233 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005159."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/117; endpoint types: /individuals/197/type; /individuals/198/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-119_d9170f7ff8b7	SGD:S000000400	pathwaymech:enables	gomodel:PGLUCISOM-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PGLUCISOM-RXN RO:0002333 gomodel:YBR196C-MONOMER_PGLUCISOM-RXN_controller."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/118; endpoint types: /individuals/42/type; /individuals/46/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-120_03ea3da92ff4	gomodel:PHOSGLYPHOS-RXN	BFO:0000050	GO:0006094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSGLYPHOS-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/119; endpoint types: /individuals/43/type; /individuals/134/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-121_428a3d874dfc	gomodel:PHOSGLYPHOS-RXN	RO:0002413	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002413 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/120; endpoint types: /individuals/43/type; /individuals/197/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-122_4ccdd8b0e611	gomodel:PYRUVATE-CARBOXYLASE-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_456216_PYRUVATE-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/121; endpoint types: /individuals/44/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-123_3731c9c1b9a6	gomodel:1.1.1.39-RXN	RO:0002234	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36013|gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:1.1.1.39-RXN RO:0002234 gomodel:CHEBI_15361_1.1.1.39-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/122; endpoint types: /individuals/132/type; /individuals/0/type""}, {""reference_id"": ""UniProtKB:P36013"", ""source_assertion"": ""UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P36013"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36013 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-124_6689b9fbd543	gomodel:1.1.1.39-RXN	RO:0002413	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36013|gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:1.1.1.39-RXN RO:0002413 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/123; endpoint types: /individuals/132/type; /individuals/146/type""}, {""reference_id"": ""UniProtKB:P36013"", ""source_assertion"": ""UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P36013"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36013 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-125_88038c61e105	gomodel:PHOSGLYPHOS-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSGLYPHOS-RXN BFO:0000066 gomodel:reaction_PHOSGLYPHOS-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/124; endpoint types: /individuals/43/type; /individuals/129/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-126_9df5d169e73d	gomodel:PHOSGLYPHOS-RXN	RO:0002233	CHEBI:58272	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002233 gomodel:CHEBI_58272_RXN-15513."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/125; endpoint types: /individuals/43/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-127_47e4f18b6f72	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158	BFO:0000050	GO:0006094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/126; endpoint types: /individuals/197/type; /individuals/134/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-128_9f338bfea35d	SGD:S000003588	pathwaymech:enables	gomodel:GAPOXNPHOSPHN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002333 gomodel:YJL052W-MONOMER_GAPOXNPHOSPHN-RXN_controller."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/127; endpoint types: /individuals/39/type; /individuals/50/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-129_391ad8d0b5b2	gomodel:PHOSGLYPHOS-RXN	RO:0002413	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002413 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/128; endpoint types: /individuals/43/type; /individuals/179/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-130_2edee44ce625	gomodel:MALATE-DEH-RXN	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:MALATE-DEH-RXN RO:0002234 gomodel:CHEBI_57945_MALATE-DEH-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/129; endpoint types: /individuals/40/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-131_e4db30b8eef9	SGD:S000001543	pathwaymech:enables	gomodel:F16ALDOLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:F16ALDOLASE-RXN RO:0002333 gomodel:YKL060C-MONOMER_F16ALDOLASE-RXN_controller."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/130; endpoint types: /individuals/37/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-132_ac4ca6b8c011	gomodel:F16BDEPHOS-RXN	RO:0002234	CHEBI:57634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:F16BDEPHOS-RXN RO:0002234 gomodel:CHEBI_57634_F16BDEPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/131; endpoint types: /individuals/38/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-133_8b1dfae5f4e3	gomodel:1.1.1.39-RXN	RO:0002233	CHEBI:15589	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36013|gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:1.1.1.39-RXN RO:0002233 gomodel:CHEBI_15589_1.1.1.39-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/132; endpoint types: /individuals/132/type; /individuals/6/type""}, {""reference_id"": ""UniProtKB:P36013"", ""source_assertion"": ""UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P36013"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36013 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-134_59b21a3f82ba	gomodel:PEPCARBOXYKIN-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PEPCARBOXYKIN-RXN RO:0002234 gomodel:CHEBI_456216_PEPCARBOXYKIN-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/133; endpoint types: /individuals/41/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-135_20ef1e3c2389	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103	BFO:0000050	GO:0006094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/134; endpoint types: /individuals/146/type; /individuals/134/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-136_f7bd3a6c3797	gomodel:RXN-15513	RO:0002234	CHEBI:58272	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN-15513 RO:0002234 gomodel:CHEBI_58272_RXN-15513."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/135; endpoint types: /individuals/45/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-137_eb181c92d366	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125	RO:0002413	gomodel:RXN-15513	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125 RO:0002413 gomodel:RXN-15513."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/136; endpoint types: /individuals/167/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-138_ca31c863ae9c	SGD:S000003769	pathwaymech:enables	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 RO:0002333 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005143."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/137; endpoint types: /individuals/179/type; /individuals/184/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-139_239deca28313	gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 RO:0002234 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005107."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/138; endpoint types: /individuals/146/type; /individuals/150/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_edge-140_6fb2915b0d65	gomodel:PEPCARBOXYKIN-RXN	RO:0002234	CHEBI:58702	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLUCONEO-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PEPCARBOXYKIN-RXN RO:0002234 gomodel:CHEBI_58702_PEPCARBOXYKIN-RXN."", ""source_locator"": ""./YeastPathways_GLUCONEO-PWY-1.json#/facts/139; endpoint types: /individuals/41/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLUCONEO-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json"", ""title"": ""SGD GO-CAM gluconeogenesis I model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_location-995a2bd5427a_dccd5719aafc	SGD:S000001635	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00950	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P00950"", ""source_assertion"": ""UniProtKB:P00950 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/51/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00950"", ""source_assertion"": ""UniProtKB:P00950 has the exact SGD cross-reference SGD:S000001635."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/51/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00950"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00950 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_location-9e0c57d7a56f_fe0db26fb463	SGD:S000001635	RO:0001025	GO:0005741	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00950	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961); ECO:0000269 (PubMed:16962558) Topology: Peripheral membrane protein. Orientation: Cytoplasmic side.	"[{""reference_id"": ""UniProtKB:P00950"", ""source_assertion"": ""UniProtKB:P00950 annotates location Mitochondrion outer membrane (SL-0172)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/51/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00950"", ""source_assertion"": ""UniProtKB:P00950 has the exact SGD cross-reference SGD:S000001635."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/51/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00950"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00950 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_location-3f0bc85a8101_c781f73a854f	SGD:S000001635	RO:0001025	GO:0005758	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00950	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:22984289)	"[{""reference_id"": ""UniProtKB:P00950"", ""source_assertion"": ""UniProtKB:P00950 annotates location Mitochondrion intermembrane space (SL-0169)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/51/comments/1/subcellularLocations/2; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00950"", ""source_assertion"": ""UniProtKB:P00950 has the exact SGD cross-reference SGD:S000001635."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/51/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00950"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00950 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_location-e725c9fd6edf_ad8700547e84	SGD:S000001512	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36013	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14576278); ECO:0000269 (PubMed:9603875)	"[{""reference_id"": ""UniProtKB:P36013"", ""source_assertion"": ""UniProtKB:P36013 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3501/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P36013"", ""source_assertion"": ""UniProtKB:P36013 has the exact SGD cross-reference SGD:S000001512."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3501/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P36013"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36013 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_location-a8e2b9a83bfa_a1aecec05315	SGD:S000003424	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00359	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11502169)	"[{""reference_id"": ""UniProtKB:P00359"", ""source_assertion"": ""UniProtKB:P00359 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/25/comments/2/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00359"", ""source_assertion"": ""UniProtKB:P00359 has the exact SGD cross-reference SGD:S000003424."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/25/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00359"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00359 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_location-f188f7b48d25_b4c2c7030a18	SGD:S000003424	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00359	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961)	"[{""reference_id"": ""UniProtKB:P00359"", ""source_assertion"": ""UniProtKB:P00359 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/25/comments/2/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00359"", ""source_assertion"": ""UniProtKB:P00359 has the exact SGD cross-reference SGD:S000003424."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/25/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00359"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00359 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_location-d86060e3e797_30a3eb5dac81	SGD:S000000605	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00560	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11502169)	"[{""reference_id"": ""UniProtKB:P00560"", ""source_assertion"": ""UniProtKB:P00560 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/35/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00560"", ""source_assertion"": ""UniProtKB:P00560 has the exact SGD cross-reference SGD:S000000605."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/35/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00560"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00560 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_location-055d2285e273_b18c59af3eb5	SGD:S000000605	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00560	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961)	"[{""reference_id"": ""UniProtKB:P00560"", ""source_assertion"": ""UniProtKB:P00560 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/35/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00560"", ""source_assertion"": ""UniProtKB:P00560 has the exact SGD cross-reference SGD:S000000605."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/35/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00560"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00560 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_location-7a7182b40019_b0862785ae32	SGD:S000005486	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P22133	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P22133"", ""source_assertion"": ""UniProtKB:P22133 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/571/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P22133"", ""source_assertion"": ""UniProtKB:P22133 has the exact SGD cross-reference SGD:S000005486."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/571/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P22133"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P22133 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_location-8718d4e89471_71b93fb82259	SGD:S000001217	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00925	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P00925"", ""source_assertion"": ""UniProtKB:P00925 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/47/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00925"", ""source_assertion"": ""UniProtKB:P00925 has the exact SGD cross-reference SGD:S000001217."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/47/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00925"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00925 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_location-96a7adf0b4a0_b0234523ea08	SGD:S000003486	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00924	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11502169)	"[{""reference_id"": ""UniProtKB:P00924"", ""source_assertion"": ""UniProtKB:P00924 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/46/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00924"", ""source_assertion"": ""UniProtKB:P00924 has the exact SGD cross-reference SGD:S000003486."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/46/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00924"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00924 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_location-900428dafe53_1ee1dada40cc	SGD:S000000422	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32327	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P32327"", ""source_assertion"": ""UniProtKB:P32327 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/866/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32327"", ""source_assertion"": ""UniProtKB:P32327 has the exact SGD cross-reference SGD:S000000422."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/866/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32327"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32327 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_location-addfaa29f6ad_4d5ee38140df	SGD:S000003030	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P11154	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P11154"", ""source_assertion"": ""UniProtKB:P11154 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/322/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P11154"", ""source_assertion"": ""UniProtKB:P11154 has the exact SGD cross-reference SGD:S000003030."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/322/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P11154"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P11154 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_location-94ccb8db9154_997f8c7267c8	SGD:S000000400	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P12709	Physical protein location from reviewed UniProt. ECO:0000250 (UniProtKB:P78917)	"[{""reference_id"": ""UniProtKB:P12709"", ""source_assertion"": ""UniProtKB:P12709 annotates location Cytoplasm, cytosol (SL-0091)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/351/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P12709"", ""source_assertion"": ""UniProtKB:P12709 has the exact SGD cross-reference SGD:S000000400."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/351/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P12709"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P12709 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_location-a76a36361920_ef9b48033a7f	SGD:S000003588	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00360	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11502169)	"[{""reference_id"": ""UniProtKB:P00360"", ""source_assertion"": ""UniProtKB:P00360 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/26/comments/2/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00360"", ""source_assertion"": ""UniProtKB:P00360 has the exact SGD cross-reference SGD:S000003588."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/26/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00360"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00360 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_location-68361c03bd91_663d10af3688	SGD:S000003769	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00358	Physical protein location from reviewed UniProt. ECO:0000250 (UniProtKB:P00360)	"[{""reference_id"": ""UniProtKB:P00358"", ""source_assertion"": ""UniProtKB:P00358 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/24/comments/2/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00358"", ""source_assertion"": ""UniProtKB:P00358 has the exact SGD cross-reference SGD:S000003769."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/24/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00358"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00358 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_cofactor-d2b601ee707b_07f7a74f70af	SGD:S000001512	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36013	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P23368) Divalent metal cations. Prefers magnesium or manganese. UniProt note evidence: ECO:0000250 (UniProtKB:P23368)	"[{""reference_id"": ""UniProtKB:P36013"", ""source_assertion"": ""UniProtKB:P36013 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3501/comments/0/cofactors/0; /results/3501/comments/0/note""}, {""reference_id"": ""UniProtKB:P36013"", ""source_assertion"": ""UniProtKB:P36013 has the exact SGD cross-reference SGD:S000001512."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3501/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P36013"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36013 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_cofactor-be47209ab4b0_4be157a1ad31	SGD:S000001512	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36013	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P23368) Divalent metal cations. Prefers magnesium or manganese. UniProt note evidence: ECO:0000250 (UniProtKB:P23368)	"[{""reference_id"": ""UniProtKB:P36013"", ""source_assertion"": ""UniProtKB:P36013 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3501/comments/0/cofactors/1; /results/3501/comments/0/note""}, {""reference_id"": ""UniProtKB:P36013"", ""source_assertion"": ""UniProtKB:P36013 has the exact SGD cross-reference SGD:S000001512."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3501/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P36013"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36013 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_cofactor-4189dbdb3e8f_f32d3fa99f86	SGD:S000000605	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00560	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00558)	"[{""reference_id"": ""UniProtKB:P00560"", ""source_assertion"": ""UniProtKB:P00560 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/35/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P00560"", ""source_assertion"": ""UniProtKB:P00560 has the exact SGD cross-reference SGD:S000000605."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/35/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00560"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00560 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_cofactor-a822dbca7d45_0814a04e2af0	SGD:S000001217	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00925	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified Mg(2+) is required for catalysis and for stabilizing the dimer.	"[{""reference_id"": ""UniProtKB:P00925"", ""source_assertion"": ""UniProtKB:P00925 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/47/comments/0/cofactors/0; /results/47/comments/0/note""}, {""reference_id"": ""UniProtKB:P00925"", ""source_assertion"": ""UniProtKB:P00925 has the exact SGD cross-reference SGD:S000001217."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/47/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00925"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00925 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_cofactor-444604e711dc_e604b4923f51	SGD:S000004369	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09201	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00636) Binds 3 Mg(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00636)	"[{""reference_id"": ""UniProtKB:P09201"", ""source_assertion"": ""UniProtKB:P09201 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/222/comments/0/cofactors/0; /results/222/comments/0/note""}, {""reference_id"": ""UniProtKB:P09201"", ""source_assertion"": ""UniProtKB:P09201 has the exact SGD cross-reference SGD:S000004369."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/222/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P09201"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P09201 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_cofactor-56dca68539a9_2ed72e755556	SGD:S000003486	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00924	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:8605183) Mg(2+) is required for catalysis and for stabilizing the dimer. UniProt note evidence: ECO:0000269 (PubMed:8605183)	"[{""reference_id"": ""UniProtKB:P00924"", ""source_assertion"": ""UniProtKB:P00924 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/46/comments/0/cofactors/0; /results/46/comments/0/note""}, {""reference_id"": ""UniProtKB:P00924"", ""source_assertion"": ""UniProtKB:P00924 has the exact SGD cross-reference SGD:S000003486."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/46/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00924"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00924 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_cofactor-ea39fb0d9a18_2adc25577520	SGD:S000000422	pathwaymech:has_cofactor	CHEBI:57586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32327	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P32327"", ""source_assertion"": ""UniProtKB:P32327 annotates CHEBI:57586 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/866/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P32327"", ""source_assertion"": ""UniProtKB:P32327 has the exact SGD cross-reference SGD:S000000422."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/866/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32327"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32327 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_cofactor-4a3243df50b7_883ba2d0c452	SGD:S000000422	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32327	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P32327"", ""source_assertion"": ""UniProtKB:P32327 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/866/comments/1/cofactors/0""}, {""reference_id"": ""UniProtKB:P32327"", ""source_assertion"": ""UniProtKB:P32327 has the exact SGD cross-reference SGD:S000000422."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/866/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32327"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32327 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_cofactor-3a9b45fb14f3_f824eebb2d05	SGD:S000003030	pathwaymech:has_cofactor	CHEBI:57586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P11154	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P11154"", ""source_assertion"": ""UniProtKB:P11154 annotates CHEBI:57586 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/322/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P11154"", ""source_assertion"": ""UniProtKB:P11154 has the exact SGD cross-reference SGD:S000003030."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/322/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P11154"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P11154 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_cofactor-9d5cb52383e9_b8569f435932	SGD:S000003030	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P11154	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P11154"", ""source_assertion"": ""UniProtKB:P11154 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/322/comments/1/cofactors/0""}, {""reference_id"": ""UniProtKB:P11154"", ""source_assertion"": ""UniProtKB:P11154 has the exact SGD cross-reference SGD:S000003030."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/322/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P11154"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P11154 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLUCONEO-PWY-1_cofactor-38fe84efc750_ed555a76f3ee	SGD:S000001543	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P14540	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P14540"", ""source_assertion"": ""UniProtKB:P14540 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/387/comments/0/cofactors/0; /results/387/comments/0/note""}, {""reference_id"": ""UniProtKB:P14540"", ""source_assertion"": ""UniProtKB:P14540 has the exact SGD cross-reference SGD:S000001543."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/387/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P14540"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P14540 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP556_causal-review-1_8ca707218cfa	CHEBI:57706	pathwaymech:consumes	WikiPathways:WP556/adc8e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP556		"[{""reference_id"": ""WikiPathways:WP556"", ""source_assertion"": ""GPML adc8e connects normalized CHEBI:57706 as an input of interaction adc8e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='adc8e']/Graphics; /Pathway/DataNode[@GraphId='a723b']""}]"	"[{""id"": ""WikiPathways:WP556"", ""source_sha256"": ""314f01ffb49864cf442ff1269bd6c6161feee3f0c2c419c1b547ede70e5e6a43"", ""source_version"": ""WP556_r140475"", ""title"": ""WP556 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP556/WP556.gpml""}]"	""
pathwaymech:WikiPathways_WP556_causal-review-2_a9819f6ba8d0	WikiPathways:WP556/adc8e	pathwaymech:produces	CHEBI:30031	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP556		"[{""reference_id"": ""WikiPathways:WP556"", ""source_assertion"": ""GPML adc8e connects normalized CHEBI:30031 as an output of interaction adc8e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='adc8e']/Graphics; /Pathway/DataNode[@GraphId='da8fc']""}]"	"[{""id"": ""WikiPathways:WP556"", ""source_sha256"": ""314f01ffb49864cf442ff1269bd6c6161feee3f0c2c419c1b547ede70e5e6a43"", ""source_version"": ""WP556_r140475"", ""title"": ""WP556 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP556/WP556.gpml""}]"	""
pathwaymech:WikiPathways_WP556_causal-review-3_fd68ae34eb66	CHEBI:59888	pathwaymech:consumes	WikiPathways:WP556/b960c	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP556		"[{""reference_id"": ""WikiPathways:WP556"", ""source_assertion"": ""GPML b960c connects normalized CHEBI:59888 as an input of interaction b960c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='b960c']/Graphics; /Pathway/DataNode[@GraphId='d8b29']""}]"	"[{""id"": ""WikiPathways:WP556"", ""source_sha256"": ""314f01ffb49864cf442ff1269bd6c6161feee3f0c2c419c1b547ede70e5e6a43"", ""source_version"": ""WP556_r140475"", ""title"": ""WP556 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP556/WP556.gpml""}]"	""
pathwaymech:WikiPathways_WP556_causal-review-4_11f37be0229e	WikiPathways:WP556/b960c	pathwaymech:produces	CHEBI:57706	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP556		"[{""reference_id"": ""WikiPathways:WP556"", ""source_assertion"": ""GPML b960c connects normalized CHEBI:57706 as an output of interaction b960c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='b960c']/Graphics; /Pathway/DataNode[@GraphId='a723b']""}]"	"[{""id"": ""WikiPathways:WP556"", ""source_sha256"": ""314f01ffb49864cf442ff1269bd6c6161feee3f0c2c419c1b547ede70e5e6a43"", ""source_version"": ""WP556_r140475"", ""title"": ""WP556 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP556/WP556.gpml""}]"	""
pathwaymech:WikiPathways_WP556_causal-review-5_43d86e705557	CHEBI:29985	pathwaymech:consumes	WikiPathways:WP556/id1356da06	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP556		"[{""reference_id"": ""WikiPathways:WP556"", ""source_assertion"": ""GPML id1356da06 connects normalized CHEBI:29985 as an input of interaction id1356da06."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id1356da06']/Graphics; /Pathway/DataNode[@GraphId='dd2e6']""}]"	"[{""id"": ""WikiPathways:WP556"", ""source_sha256"": ""314f01ffb49864cf442ff1269bd6c6161feee3f0c2c419c1b547ede70e5e6a43"", ""source_version"": ""WP556_r140475"", ""title"": ""WP556 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP556/WP556.gpml""}]"	""
pathwaymech:WikiPathways_WP556_causal-review-6_2e6fe34b1c69	WikiPathways:WP556/id1356da06	pathwaymech:produces	CHEBI:59888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP556		"[{""reference_id"": ""WikiPathways:WP556"", ""source_assertion"": ""GPML id1356da06 connects normalized CHEBI:59888 as an output of interaction id1356da06."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id1356da06']/Graphics; /Pathway/DataNode[@GraphId='d8b29']""}]"	"[{""id"": ""WikiPathways:WP556"", ""source_sha256"": ""314f01ffb49864cf442ff1269bd6c6161feee3f0c2c419c1b547ede70e5e6a43"", ""source_version"": ""WP556_r140475"", ""title"": ""WP556 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP556/WP556.gpml""}]"	""
pathwaymech:WikiPathways_WP556_causal-review-7_58484e2c001c	CHEBI:15377	pathwaymech:consumes	WikiPathways:WP556/adc8e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP556		"[{""reference_id"": ""WikiPathways:WP556"", ""source_assertion"": ""GPML id38174c4f connects normalized CHEBI:15377 as an input of interaction adc8e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id38174c4f']/Graphics; /Pathway/DataNode[@GraphId='a17a6']""}]"	"[{""id"": ""WikiPathways:WP556"", ""source_sha256"": ""314f01ffb49864cf442ff1269bd6c6161feee3f0c2c419c1b547ede70e5e6a43"", ""source_version"": ""WP556_r140475"", ""title"": ""WP556 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP556/WP556.gpml""}]"	""
pathwaymech:WikiPathways_WP556_causal-review-8_33a68984b47b	CHEBI:13390	pathwaymech:consumes	WikiPathways:WP556/adc8e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP556		"[{""reference_id"": ""WikiPathways:WP556"", ""source_assertion"": ""GPML id38174c4f connects normalized CHEBI:13390 as an input of interaction adc8e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id38174c4f']/Graphics; /Pathway/DataNode[@GraphId='de987']""}]"	"[{""id"": ""WikiPathways:WP556"", ""source_sha256"": ""314f01ffb49864cf442ff1269bd6c6161feee3f0c2c419c1b547ede70e5e6a43"", ""source_version"": ""WP556_r140475"", ""title"": ""WP556 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP556/WP556.gpml""}]"	""
pathwaymech:WikiPathways_WP556_causal-review-9_97500fb2c591	WikiPathways:WP556/id1356da06	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP556		"[{""reference_id"": ""WikiPathways:WP556"", ""source_assertion"": ""GPML id5fc21733 connects normalized CHEBI:16526 as an output of interaction id1356da06."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5fc21733']/Graphics; /Pathway/DataNode[@GraphId='c50ae']""}]"	"[{""id"": ""WikiPathways:WP556"", ""source_sha256"": ""314f01ffb49864cf442ff1269bd6c6161feee3f0c2c419c1b547ede70e5e6a43"", ""source_version"": ""WP556_r140475"", ""title"": ""WP556 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP556/WP556.gpml""}]"	""
pathwaymech:WikiPathways_WP556_causal-review-10_7d9e717de327	CHEBI:16810	pathwaymech:consumes	WikiPathways:WP556/b960c	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP556		"[{""reference_id"": ""WikiPathways:WP556"", ""source_assertion"": ""GPML id76efa8ad connects normalized CHEBI:16810 as an input of interaction b960c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id76efa8ad']/Graphics; /Pathway/DataNode[@GraphId='c7eed']""}]"	"[{""id"": ""WikiPathways:WP556"", ""source_sha256"": ""314f01ffb49864cf442ff1269bd6c6161feee3f0c2c419c1b547ede70e5e6a43"", ""source_version"": ""WP556_r140475"", ""title"": ""WP556 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP556/WP556.gpml""}]"	""
pathwaymech:WikiPathways_WP556_causal-review-11_bb6c84328a1c	SGD:S000003251	pathwaymech:catalyzes	WikiPathways:WP556/b960c	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP556		"[{""reference_id"": ""WikiPathways:WP556"", ""source_assertion"": ""GPML id77422312 connects normalized SGD:S000003251 as a catalyst of interaction b960c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id77422312']/Graphics; /Pathway/DataNode[@GraphId='e9564']""}]"	"[{""id"": ""WikiPathways:WP556"", ""source_sha256"": ""314f01ffb49864cf442ff1269bd6c6161feee3f0c2c419c1b547ede70e5e6a43"", ""source_version"": ""WP556_r140475"", ""title"": ""WP556 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP556/WP556.gpml""}]"	""
pathwaymech:WikiPathways_WP556_causal-review-12_e999e9c04765	CHEBI:15378	pathwaymech:consumes	WikiPathways:WP556/id1356da06	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP556		"[{""reference_id"": ""WikiPathways:WP556"", ""source_assertion"": ""GPML idad51913f connects normalized CHEBI:15378 as an input of interaction id1356da06."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idad51913f']/Graphics; /Pathway/DataNode[@GraphId='f9274']""}]"	"[{""id"": ""WikiPathways:WP556"", ""source_sha256"": ""314f01ffb49864cf442ff1269bd6c6161feee3f0c2c419c1b547ede70e5e6a43"", ""source_version"": ""WP556_r140475"", ""title"": ""WP556 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP556/WP556.gpml""}]"	""
pathwaymech:WikiPathways_WP556_causal-review-13_ca66b2f9ac60	SGD:S000000210	pathwaymech:catalyzes	WikiPathways:WP556/adc8e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP556		"[{""reference_id"": ""WikiPathways:WP556"", ""source_assertion"": ""GPML idc91f98e3 connects normalized SGD:S000000210 as a catalyst of interaction adc8e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idc91f98e3']/Graphics; /Pathway/DataNode[@GraphId='a67d0']""}]"	"[{""id"": ""WikiPathways:WP556"", ""source_sha256"": ""314f01ffb49864cf442ff1269bd6c6161feee3f0c2c419c1b547ede70e5e6a43"", ""source_version"": ""WP556_r140475"", ""title"": ""WP556 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP556/WP556.gpml""}]"	""
pathwaymech:WikiPathways_WP556_causal-review-14_736407c73b48	WikiPathways:WP556/b960c	pathwaymech:produces	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP556		"[{""reference_id"": ""WikiPathways:WP556"", ""source_assertion"": ""GPML ide9dea94f connects normalized CHEBI:29985 as an output of interaction b960c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ide9dea94f']/Graphics; /Pathway/DataNode[@GraphId='a55ec']""}]"	"[{""id"": ""WikiPathways:WP556"", ""source_sha256"": ""314f01ffb49864cf442ff1269bd6c6161feee3f0c2c419c1b547ede70e5e6a43"", ""source_version"": ""WP556_r140475"", ""title"": ""WP556 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP556/WP556.gpml""}]"	""
pathwaymech:WikiPathways_WP556_causal-review-15_d02a9aec1a1a	SGD:S000004862	pathwaymech:catalyzes	WikiPathways:WP556/id1356da06	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP556		"[{""reference_id"": ""WikiPathways:WP556"", ""source_assertion"": ""GPML idf2f34343 connects normalized SGD:S000004862 as a catalyst of interaction id1356da06."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idf2f34343']/Graphics; /Pathway/DataNode[@GraphId='d1e']""}]"	"[{""id"": ""WikiPathways:WP556"", ""source_sha256"": ""314f01ffb49864cf442ff1269bd6c6161feee3f0c2c419c1b547ede70e5e6a43"", ""source_version"": ""WP556_r140475"", ""title"": ""WP556 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP556/WP556.gpml""}]"	""
pathwaymech:WikiPathways_WP556_causal-review-16_01562bdbfd67	WikiPathways:WP556/adc8e	pathwaymech:produces	CHEBI:13392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP556		"[{""reference_id"": ""WikiPathways:WP556"", ""source_assertion"": ""GPML e831d connects normalized CHEBI:13392 as an output of interaction adc8e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='e831d']/Graphics; /Pathway/DataNode[@GraphId='cb0a1']""}]"	"[{""id"": ""WikiPathways:WP556"", ""source_sha256"": ""314f01ffb49864cf442ff1269bd6c6161feee3f0c2c419c1b547ede70e5e6a43"", ""source_version"": ""WP556_r140475"", ""title"": ""WP556 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP556/WP556.gpml""}]"	""
pathwaymech:WikiPathways_WP556_causal-review-17_e1f260265ad1	WikiPathways:WP556/adc8e	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP556		"[{""reference_id"": ""WikiPathways:WP556"", ""source_assertion"": ""GPML e831d connects normalized CHEBI:15378 as an output of interaction adc8e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='e831d']/Graphics; /Pathway/DataNode[@GraphId='c9d82']; /Pathway/DataNode[@GraphId='f708d']""}]"	"[{""id"": ""WikiPathways:WP556"", ""source_sha256"": ""314f01ffb49864cf442ff1269bd6c6161feee3f0c2c419c1b547ede70e5e6a43"", ""source_version"": ""WP556_r140475"", ""title"": ""WP556 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP556/WP556.gpml""}]"	""
pathwaymech:WikiPathways_WP556_cofactor-fcb2daae135a_aa16aca7c466	SGD:S000004862	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q04792	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:Q04792"", ""source_assertion"": ""UniProtKB:Q04792 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4938/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:Q04792"", ""source_assertion"": ""UniProtKB:Q04792 has the exact SGD cross-reference SGD:S000004862."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4938/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q04792"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB Q04792 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP556_cofactor-2a5c0a452713_c98840c3acf1	SGD:S000003251	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P17649	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:17355287)	"[{""reference_id"": ""UniProtKB:P17649"", ""source_assertion"": ""UniProtKB:P17649 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/468/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P17649"", ""source_assertion"": ""UniProtKB:P17649 has the exact SGD cross-reference SGD:S000003251."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/468/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P17649"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P17649 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-001_8027d46bf544	CHEBI:29985	pathwaymech:consumes	RHEA:13286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13286		"[{""reference_id"": ""RHEA:13286"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the substrates side of RHEA:13286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13286']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13286"", ""source_version"": ""139"", ""title"": ""Rhea gamma-glutamylcysteine-forming glutamate--cysteine ligase direction"", ""url"": ""https://www.rhea-db.org/rhea/13286""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-002_52b5b56dc5a0	CHEBI:30616	pathwaymech:consumes	RHEA:13286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13286		"[{""reference_id"": ""RHEA:13286"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:13286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13286']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13286"", ""source_version"": ""139"", ""title"": ""Rhea gamma-glutamylcysteine-forming glutamate--cysteine ligase direction"", ""url"": ""https://www.rhea-db.org/rhea/13286""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-003_b355e599282f	CHEBI:35235	pathwaymech:consumes	RHEA:13286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13286		"[{""reference_id"": ""RHEA:13286"", ""source_assertion"": ""Rhea lists CHEBI:35235 on the substrates side of RHEA:13286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13286']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13286"", ""source_version"": ""139"", ""title"": ""Rhea gamma-glutamylcysteine-forming glutamate--cysteine ligase direction"", ""url"": ""https://www.rhea-db.org/rhea/13286""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-004_5035aaf0319a	RHEA:13286	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13286		"[{""reference_id"": ""RHEA:13286"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:13286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13286']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13286"", ""source_version"": ""139"", ""title"": ""Rhea gamma-glutamylcysteine-forming glutamate--cysteine ligase direction"", ""url"": ""https://www.rhea-db.org/rhea/13286""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-005_1a00d560e298	RHEA:13286	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13286		"[{""reference_id"": ""RHEA:13286"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:13286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13286']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13286"", ""source_version"": ""139"", ""title"": ""Rhea gamma-glutamylcysteine-forming glutamate--cysteine ligase direction"", ""url"": ""https://www.rhea-db.org/rhea/13286""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-006_d11af59c43ea	RHEA:13286	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13286		"[{""reference_id"": ""RHEA:13286"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:13286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13286']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13286"", ""source_version"": ""139"", ""title"": ""Rhea gamma-glutamylcysteine-forming glutamate--cysteine ligase direction"", ""url"": ""https://www.rhea-db.org/rhea/13286""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-007_5cd70a1bcf92	RHEA:13286	pathwaymech:produces	CHEBI:58173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13286		"[{""reference_id"": ""RHEA:13286"", ""source_assertion"": ""Rhea lists CHEBI:58173 on the products side of RHEA:13286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13286']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13286"", ""source_version"": ""139"", ""title"": ""Rhea gamma-glutamylcysteine-forming glutamate--cysteine ligase direction"", ""url"": ""https://www.rhea-db.org/rhea/13286""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-008_3572f82fba96	CHEBI:30616	pathwaymech:consumes	RHEA:13558	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13558		"[{""reference_id"": ""RHEA:13558"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:13558 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13558']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13558"", ""source_version"": ""139"", ""title"": ""Rhea glutathione-forming glutathione synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/13558""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-009_e1acdc9cdc89	CHEBI:57305	pathwaymech:consumes	RHEA:13558	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13558		"[{""reference_id"": ""RHEA:13558"", ""source_assertion"": ""Rhea lists CHEBI:57305 on the substrates side of RHEA:13558 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13558']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13558"", ""source_version"": ""139"", ""title"": ""Rhea glutathione-forming glutathione synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/13558""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-010_568ba1fc10f0	CHEBI:58173	pathwaymech:consumes	RHEA:13558	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13558		"[{""reference_id"": ""RHEA:13558"", ""source_assertion"": ""Rhea lists CHEBI:58173 on the substrates side of RHEA:13558 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13558']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13558"", ""source_version"": ""139"", ""title"": ""Rhea glutathione-forming glutathione synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/13558""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-011_8aac36b14057	RHEA:13558	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13558		"[{""reference_id"": ""RHEA:13558"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:13558 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13558']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13558"", ""source_version"": ""139"", ""title"": ""Rhea glutathione-forming glutathione synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/13558""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-012_b8b5c26e8bd8	RHEA:13558	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13558		"[{""reference_id"": ""RHEA:13558"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:13558 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13558']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13558"", ""source_version"": ""139"", ""title"": ""Rhea glutathione-forming glutathione synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/13558""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-013_22e4d58ee112	RHEA:13558	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13558		"[{""reference_id"": ""RHEA:13558"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:13558 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13558']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13558"", ""source_version"": ""139"", ""title"": ""Rhea glutathione-forming glutathione synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/13558""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-014_2f0a3ad7741e	RHEA:13558	pathwaymech:produces	CHEBI:57925	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13558		"[{""reference_id"": ""RHEA:13558"", ""source_assertion"": ""Rhea lists CHEBI:57925 on the products side of RHEA:13558 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13558']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13558"", ""source_version"": ""139"", ""title"": ""Rhea glutathione-forming glutathione synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/13558""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-015_2673a4908dd8	EC:6.3.2.2	pathwaymech:catalyzes	RHEA:13286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11675389|RHEA:13285		"[{""reference_id"": ""RHEA:13285"", ""source_assertion"": ""Rhea associates EC:6.3.2.2 with the reaction family containing RHEA:13286."", ""source_locator"": ""rh:ec""}, {""quote"": ""Escherichia coli gamma-glutamylcysteine synthetase. Two active site metal ions affect substrate and inhibitor binding."", ""reference_id"": ""PMID:11675389"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Kelly et al., Journal of Biological Chemistry, 2002"", ""id"": ""PMID:11675389"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/11675389/""}, {""id"": ""RHEA:13285"", ""source_version"": ""139"", ""title"": ""Rhea glutamate--cysteine ligase reaction"", ""url"": ""https://www.rhea-db.org/rhea/13285""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-016_4a38ca82b862	EC:6.3.2.3	pathwaymech:catalyzes	RHEA:13558	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:8810901|RHEA:13557		"[{""reference_id"": ""RHEA:13557"", ""source_assertion"": ""Rhea associates EC:6.3.2.3 with the reaction family containing RHEA:13558."", ""source_locator"": ""rh:ec""}, {""quote"": ""A pseudo-michaelis quaternary complex in the reverse reaction of a ligase: structure of Escherichia coli B glutathione synthetase complexed with ADP, glutathione, and sulfate at 2.0 A resolution."", ""reference_id"": ""PMID:8810901"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Hara et al., Biochemistry, 1996"", ""id"": ""PMID:8810901"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/8810901/""}, {""id"": ""RHEA:13557"", ""source_version"": ""139"", ""title"": ""Rhea glutathione synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/13557""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-017_f9c0eb436013	RHEA:13286	pathwaymech:precedes	RHEA:13558	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLUTATHIONESYN-PWY		"[{""reference_id"": ""MetaCyc:GLUTATHIONESYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:13286 before RHEA:13558 in this pathway. Shared intermediate: CHEBI:58173."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GLUTATHIONESYN-PWY"", ""source_sha256"": ""8ebb2db038ee89b2c6f98042a19cc88ec49853c61d661addc17a2a8b70cfba3e"", ""source_version"": ""22.5"", ""title"": ""MetaCyc glutathione biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLUTATHIONESYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-018_e8c7046045f3	UniProtKB:P04425	pathwaymech:enables	RHEA:13558	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P04425		"[{""reference_id"": ""UniProtKB:P04425"", ""source_assertion"": ""UniProt annotates UniProtKB:P04425 with catalytic activity for the reaction family of RHEA:13558. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P04425"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P04425 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P04425.json""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-019_0c57d577ccad	UniProtKB:P04425	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P04425		"[{""reference_id"": ""UniProtKB:P04425"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P04425 (evidence: ECO:0000250). Binds 1 Mg(2+) or Mn(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P04425"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P04425 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P04425.json""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-020_4ae7f81cd7a4	UniProtKB:P04425	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P04425		"[{""reference_id"": ""UniProtKB:P04425"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P04425 (evidence: ECO:0000250). Binds 1 Mg(2+) or Mn(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P04425"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P04425 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P04425.json""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-021_2d27f7ee1e41	UniProtKB:P0A6W9	pathwaymech:enables	RHEA:13286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6W9		"[{""reference_id"": ""UniProtKB:P0A6W9"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A6W9 with catalytic activity for the reaction family of RHEA:13286. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A6W9"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6W9 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6W9.json""}]"	""
pathwaymech:MetaCyc_GLUTATHIONESYN-PWY_edge-022_ac416c17600c	UniProtKB:P77213	pathwaymech:enables	RHEA:13286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77213		"[{""reference_id"": ""UniProtKB:P77213"", ""source_assertion"": ""UniProt annotates UniProtKB:P77213 with catalytic activity for the reaction family of RHEA:13286. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P77213"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P77213 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77213.json""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_edge-001_d7c97fd8a736	gomodel:RXN-6601	BFO:0000050	GO:0006751	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWYQT-4432		"[{""reference_id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_assertion"": ""The model asserts gomodel:RXN-6601 BFO:0000050 gomodel:YeastPathways_PWYQT-4432/YeastPathways_PWYQT-4432."", ""source_locator"": ""./YeastPathways_PWYQT-4432.json#/facts/0; endpoint types: /individuals/6/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWYQT-4432.json"", ""title"": ""GO-CAM glutathione degradation model YeastPathways_PWYQT-4432"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_edge-002_8721c9c374da	gomodel:RXN-6601	RO:0002234	CHEBI:61694	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWYQT-4432		"[{""reference_id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_assertion"": ""The model asserts gomodel:RXN-6601 RO:0002234 gomodel:CHEBI_61694_RXN-6601."", ""source_locator"": ""./YeastPathways_PWYQT-4432.json#/facts/1; endpoint types: /individuals/6/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWYQT-4432.json"", ""title"": ""GO-CAM glutathione degradation model YeastPathways_PWYQT-4432"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_edge-003_d5a059a14d94	gomodel:RXN-6622	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWYQT-4432		"[{""reference_id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_assertion"": ""The model asserts gomodel:RXN-6622 BFO:0000066 gomodel:reaction_RXN-6622_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWYQT-4432.json#/facts/2; endpoint types: /individuals/7/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWYQT-4432.json"", ""title"": ""GO-CAM glutathione degradation model YeastPathways_PWYQT-4432"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_edge-004_0a448594e7c3	gomodel:RXN-6622	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWYQT-4432		"[{""reference_id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_assertion"": ""The model asserts gomodel:RXN-6622 RO:0002233 gomodel:CHEBI_15377_RXN-6622."", ""source_locator"": ""./YeastPathways_PWYQT-4432.json#/facts/3; endpoint types: /individuals/7/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWYQT-4432.json"", ""title"": ""GO-CAM glutathione degradation model YeastPathways_PWYQT-4432"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_edge-005_f514b0a173a8	gomodel:RXN-6601	RO:0002233	CHEBI:16856	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWYQT-4432		"[{""reference_id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_assertion"": ""The model asserts gomodel:RXN-6601 RO:0002233 gomodel:CHEBI_57925_RXN-6601."", ""source_locator"": ""./YeastPathways_PWYQT-4432.json#/facts/4; endpoint types: /individuals/6/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWYQT-4432.json"", ""title"": ""GO-CAM glutathione degradation model YeastPathways_PWYQT-4432"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_edge-006_ce484553e849	gomodel:RXN-6622	RO:0002233	CHEBI:61694	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWYQT-4432		"[{""reference_id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_assertion"": ""The model asserts gomodel:RXN-6622 RO:0002233 gomodel:CHEBI_61694_RXN-6601."", ""source_locator"": ""./YeastPathways_PWYQT-4432.json#/facts/5; endpoint types: /individuals/7/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWYQT-4432.json"", ""title"": ""GO-CAM glutathione degradation model YeastPathways_PWYQT-4432"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_edge-008_93b29babcaed	SGD:S000001940	pathwaymech:enables	gomodel:RXN-6622	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWYQT-4432		"[{""reference_id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_assertion"": ""The model asserts gomodel:RXN-6622 RO:0002333 gomodel:YeastPathways_PWYQT-4432/6a6bcaed00000235."", ""source_locator"": ""./YeastPathways_PWYQT-4432.json#/facts/7; endpoint types: /individuals/7/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWYQT-4432.json"", ""title"": ""GO-CAM glutathione degradation model YeastPathways_PWYQT-4432"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_edge-009_380643d41c8e	gomodel:RXN-6622	RO:0002234	CHEBI:35235	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWYQT-4432		"[{""reference_id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_assertion"": ""The model asserts gomodel:RXN-6622 RO:0002234 gomodel:CHEBI_35235_RXN-6622."", ""source_locator"": ""./YeastPathways_PWYQT-4432.json#/facts/8; endpoint types: /individuals/7/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWYQT-4432.json"", ""title"": ""GO-CAM glutathione degradation model YeastPathways_PWYQT-4432"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_edge-010_0520020e4b25	gomodel:RXN-6601	RO:0002234	CHEBI:71304	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWYQT-4432		"[{""reference_id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_assertion"": ""The model asserts gomodel:RXN-6601 RO:0002234 gomodel:53e455f9-a234-432e-ade1-7720e76926f9_RXN-6601."", ""source_locator"": ""./YeastPathways_PWYQT-4432.json#/facts/9; endpoint types: /individuals/6/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWYQT-4432.json"", ""title"": ""GO-CAM glutathione degradation model YeastPathways_PWYQT-4432"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_edge-011_fd4208041ef6	gomodel:RXN-6622	BFO:0000050	GO:0006751	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWYQT-4432		"[{""reference_id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_assertion"": ""The model asserts gomodel:RXN-6622 BFO:0000050 gomodel:YeastPathways_PWYQT-4432/YeastPathways_PWYQT-4432."", ""source_locator"": ""./YeastPathways_PWYQT-4432.json#/facts/10; endpoint types: /individuals/7/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWYQT-4432.json"", ""title"": ""GO-CAM glutathione degradation model YeastPathways_PWYQT-4432"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_edge-012_4bbd80faf38d	SGD:S000004290	pathwaymech:enables	gomodel:RXN-6601	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWYQT-4432		"[{""reference_id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_assertion"": ""The model asserts gomodel:RXN-6601 RO:0002333 gomodel:YLR299W-MONOMER_RXN-6601_controller."", ""source_locator"": ""./YeastPathways_PWYQT-4432.json#/facts/11; endpoint types: /individuals/6/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWYQT-4432.json"", ""title"": ""GO-CAM glutathione degradation model YeastPathways_PWYQT-4432"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_edge-013_2d9f0c623b40	gomodel:RXN-6601	RO:0002413	gomodel:RXN-6622	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWYQT-4432		"[{""reference_id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_assertion"": ""The model asserts gomodel:RXN-6601 RO:0002413 gomodel:RXN-6622."", ""source_locator"": ""./YeastPathways_PWYQT-4432.json#/facts/12; endpoint types: /individuals/6/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWYQT-4432.json"", ""title"": ""GO-CAM glutathione degradation model YeastPathways_PWYQT-4432"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_edge-014_001cbca0b220	gomodel:RXN-6601	RO:0002233	CHEBI:83813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWYQT-4432		"[{""reference_id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_assertion"": ""The model asserts gomodel:RXN-6601 RO:0002233 gomodel:CHEBI_83813_RXN-6601."", ""source_locator"": ""./YeastPathways_PWYQT-4432.json#/facts/13; endpoint types: /individuals/6/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWYQT-4432.json"", ""title"": ""GO-CAM glutathione degradation model YeastPathways_PWYQT-4432"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_edge-015_a3a25f7ab074	gomodel:RXN-6622	RO:0002234	CHEBI:57305	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWYQT-4432		"[{""reference_id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_assertion"": ""The model asserts gomodel:RXN-6622 RO:0002234 gomodel:CHEBI_57305_RXN-6622."", ""source_locator"": ""./YeastPathways_PWYQT-4432.json#/facts/14; endpoint types: /individuals/7/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWYQT-4432"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWYQT-4432.json"", ""title"": ""GO-CAM glutathione degradation model YeastPathways_PWYQT-4432"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_location-6089201d5200_f7b26d0436e4	SGD:S000001940	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P43616	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:17179087)	"[{""reference_id"": ""UniProtKB:P43616"", ""source_assertion"": ""UniProtKB:P43616 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1878/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P43616"", ""source_assertion"": ""UniProtKB:P43616 has the exact SGD cross-reference SGD:S000001940."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1878/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P43616"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P43616 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_location-e7f190adeec2_48d463955900	SGD:S000001940	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P43616	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961)	"[{""reference_id"": ""UniProtKB:P43616"", ""source_assertion"": ""UniProtKB:P43616 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1878/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P43616"", ""source_assertion"": ""UniProtKB:P43616 has the exact SGD cross-reference SGD:S000001940."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1878/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P43616"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P43616 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_location-bcc89a0ce4ec_3e075b3b6acd	SGD:S000004290	RO:0001025	GO:0005774	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q05902	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11672438); ECO:0000269 (PubMed:6143552); ECO:0000269 (PubMed:6143574) Topology: Single-pass type II membrane protein.	"[{""reference_id"": ""UniProtKB:Q05902"", ""source_assertion"": ""UniProtKB:Q05902 annotates location Vacuole membrane (SL-0271)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2691/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q05902"", ""source_assertion"": ""UniProtKB:Q05902 has the exact SGD cross-reference SGD:S000004290."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2691/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q05902"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q05902 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_location-7b8332d5f7e0_febf0eedfc18	gomodel:RXN-6601	BFO:0000066	GO:0005773	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q05902	Activity compartment supported by an inspected functional annotation. ECO:0000269 (PubMed:11672438). Alternative isoenzymes may function elsewhere.	"[{""reference_id"": ""UniProtKB:Q05902"", ""source_assertion"": ""UniProtKB:Q05902 describes the corresponding catalytic function in the vacuole; this projection applies to the activity enabled by SGD:S000004290."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2691/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q05902"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q05902 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_cofactor-136e6a13d024_e40a88632dba	SGD:S000001940	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P43616	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:19346245)	"[{""reference_id"": ""UniProtKB:P43616"", ""source_assertion"": ""UniProtKB:P43616 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1878/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P43616"", ""source_assertion"": ""UniProtKB:P43616 has the exact SGD cross-reference SGD:S000001940."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1878/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P43616"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P43616 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWYQT-4432_cofactor-a12c3af13e2c_18376038eb09	SGD:S000001940	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P43616	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:19346245)	"[{""reference_id"": ""UniProtKB:P43616"", ""source_assertion"": ""UniProtKB:P43616 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1878/comments/0/cofactors/1""}, {""reference_id"": ""UniProtKB:P43616"", ""source_assertion"": ""UniProtKB:P43616 has the exact SGD cross-reference SGD:S000001940."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1878/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P43616"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P43616 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:WikiPathways_WP392_causal-review-1_e90655bab890	CHEBI:58297	pathwaymech:consumes	WikiPathways:WP392/id3206f739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP392		"[{""reference_id"": ""WikiPathways:WP392"", ""source_assertion"": ""GPML id3206f739 connects normalized CHEBI:58297 as an input of interaction id3206f739."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id3206f739']/Graphics; /Pathway/DataNode[@GraphId='fc211']""}]"	"[{""id"": ""WikiPathways:WP392"", ""source_sha256"": ""484f2685c03edd87cecc84c83c4b5f7fdf882fc46d040f3d43a7dd10f1d8ab9e"", ""source_version"": ""WP392_r20261002122028"", ""title"": ""WP392 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP392/WP392.gpml""}]"	""
pathwaymech:WikiPathways_WP392_causal-review-2_4ec56a78c317	WikiPathways:WP392/id3206f739	pathwaymech:produces	CHEBI:57925	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP392		"[{""reference_id"": ""WikiPathways:WP392"", ""source_assertion"": ""GPML id3206f739 connects normalized CHEBI:57925 as an output of interaction id3206f739."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id3206f739']/Graphics; /Pathway/DataNode[@GraphId='a20fb']""}]"	"[{""id"": ""WikiPathways:WP392"", ""source_sha256"": ""484f2685c03edd87cecc84c83c4b5f7fdf882fc46d040f3d43a7dd10f1d8ab9e"", ""source_version"": ""WP392_r20261002122028"", ""title"": ""WP392 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP392/WP392.gpml""}]"	""
pathwaymech:WikiPathways_WP392_causal-review-3_cd58ac907adf	CHEBI:57925	pathwaymech:consumes	WikiPathways:WP392/id8cc08cdf	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP392		"[{""reference_id"": ""WikiPathways:WP392"", ""source_assertion"": ""GPML id8cc08cdf connects normalized CHEBI:57925 as an input of interaction id8cc08cdf."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id8cc08cdf']/Graphics; /Pathway/DataNode[@GraphId='a20fb']""}]"	"[{""id"": ""WikiPathways:WP392"", ""source_sha256"": ""484f2685c03edd87cecc84c83c4b5f7fdf882fc46d040f3d43a7dd10f1d8ab9e"", ""source_version"": ""WP392_r20261002122028"", ""title"": ""WP392 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP392/WP392.gpml""}]"	""
pathwaymech:WikiPathways_WP392_causal-review-4_f75884aca10d	WikiPathways:WP392/id8cc08cdf	pathwaymech:produces	CHEBI:17021	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP392		"[{""reference_id"": ""WikiPathways:WP392"", ""source_assertion"": ""GPML id8cc08cdf connects normalized CHEBI:17021 as an output of interaction id8cc08cdf."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id8cc08cdf']/Graphics; /Pathway/DataNode[@GraphId='a3d26']""}]"	"[{""id"": ""WikiPathways:WP392"", ""source_sha256"": ""484f2685c03edd87cecc84c83c4b5f7fdf882fc46d040f3d43a7dd10f1d8ab9e"", ""source_version"": ""WP392_r20261002122028"", ""title"": ""WP392 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP392/WP392.gpml""}]"	""
pathwaymech:WikiPathways_WP392_causal-review-5_02f9805539f0	CHEBI:57925	pathwaymech:consumes	WikiPathways:WP392/idb13bbbe	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP392		"[{""reference_id"": ""WikiPathways:WP392"", ""source_assertion"": ""GPML idb13bbbe connects normalized CHEBI:57925 as an input of interaction idb13bbbe."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idb13bbbe']/Graphics; /Pathway/DataNode[@GraphId='a20fb']""}]"	"[{""id"": ""WikiPathways:WP392"", ""source_sha256"": ""484f2685c03edd87cecc84c83c4b5f7fdf882fc46d040f3d43a7dd10f1d8ab9e"", ""source_version"": ""WP392_r20261002122028"", ""title"": ""WP392 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP392/WP392.gpml""}]"	""
pathwaymech:WikiPathways_WP392_causal-review-6_6c25a6966994	WikiPathways:WP392/idb13bbbe	pathwaymech:produces	CHEBI:58297	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP392		"[{""reference_id"": ""WikiPathways:WP392"", ""source_assertion"": ""GPML idb13bbbe connects normalized CHEBI:58297 as an output of interaction idb13bbbe."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idb13bbbe']/Graphics; /Pathway/DataNode[@GraphId='fc211']""}]"	"[{""id"": ""WikiPathways:WP392"", ""source_sha256"": ""484f2685c03edd87cecc84c83c4b5f7fdf882fc46d040f3d43a7dd10f1d8ab9e"", ""source_version"": ""WP392_r20261002122028"", ""title"": ""WP392 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP392/WP392.gpml""}]"	""
pathwaymech:WikiPathways_WP392_causal-review-7_064e3a4508a6	SGD:S000006012	pathwaymech:catalyzes	WikiPathways:WP392/id3206f739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP392		"[{""reference_id"": ""WikiPathways:WP392"", ""source_assertion"": ""GPML id7dd40452 connects normalized SGD:S000006012 as a catalyst of interaction id3206f739."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id7dd40452']/Graphics; /Pathway/DataNode[@GraphId='f19']""}]"	"[{""id"": ""WikiPathways:WP392"", ""source_sha256"": ""484f2685c03edd87cecc84c83c4b5f7fdf882fc46d040f3d43a7dd10f1d8ab9e"", ""source_version"": ""WP392_r20261002122028"", ""title"": ""WP392 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP392/WP392.gpml""}]"	""
pathwaymech:WikiPathways_WP392_causal-review-8_f1246e8bc637	SGD:S000001509	pathwaymech:catalyzes	WikiPathways:WP392/idb13bbbe	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP392		"[{""reference_id"": ""WikiPathways:WP392"", ""source_assertion"": ""GPML ida03687f connects normalized SGD:S000001509 as a catalyst of interaction idb13bbbe."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ida03687f']/Graphics; /Pathway/DataNode[@GraphId='dc7']""}]"	"[{""id"": ""WikiPathways:WP392"", ""source_sha256"": ""484f2685c03edd87cecc84c83c4b5f7fdf882fc46d040f3d43a7dd10f1d8ab9e"", ""source_version"": ""WP392_r20261002122028"", ""title"": ""WP392 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP392/WP392.gpml""}]"	""
pathwaymech:WikiPathways_WP392_causal-review-9_f659d702a135	SGD:S000000448	pathwaymech:catalyzes	WikiPathways:WP392/idb13bbbe	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP392		"[{""reference_id"": ""WikiPathways:WP392"", ""source_assertion"": ""GPML ida03687f connects normalized SGD:S000000448 as a catalyst of interaction idb13bbbe."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ida03687f']/Graphics; /Pathway/DataNode[@GraphId='e13']""}]"	"[{""id"": ""WikiPathways:WP392"", ""source_sha256"": ""484f2685c03edd87cecc84c83c4b5f7fdf882fc46d040f3d43a7dd10f1d8ab9e"", ""source_version"": ""WP392_r20261002122028"", ""title"": ""WP392 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP392/WP392.gpml""}]"	""
pathwaymech:WikiPathways_WP392_causal-review-10_f3442ea1a326	SGD:S000001476	pathwaymech:catalyzes	WikiPathways:WP392/idb13bbbe	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP392		"[{""reference_id"": ""WikiPathways:WP392"", ""source_assertion"": ""GPML ida03687f connects normalized SGD:S000001476 as a catalyst of interaction idb13bbbe."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ida03687f']/Graphics; /Pathway/DataNode[@GraphId='fb3']""}]"	"[{""id"": ""WikiPathways:WP392"", ""source_sha256"": ""484f2685c03edd87cecc84c83c4b5f7fdf882fc46d040f3d43a7dd10f1d8ab9e"", ""source_version"": ""WP392_r20261002122028"", ""title"": ""WP392 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP392/WP392.gpml""}]"	""
pathwaymech:WikiPathways_WP392_causal-review-11_56ce121e385a	WikiPathways:WP392/idb13bbbe	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP392		"[{""reference_id"": ""WikiPathways:WP392"", ""source_assertion"": ""GPML idc27704ba connects normalized CHEBI:15377 as an output of interaction idb13bbbe."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idc27704ba']/Graphics; /Pathway/DataNode[@GraphId='f6c66']""}]"	"[{""id"": ""WikiPathways:WP392"", ""source_sha256"": ""484f2685c03edd87cecc84c83c4b5f7fdf882fc46d040f3d43a7dd10f1d8ab9e"", ""source_version"": ""WP392_r20261002122028"", ""title"": ""WP392 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP392/WP392.gpml""}]"	""
pathwaymech:WikiPathways_WP392_causal-review-12_db7c46683a72	SGD:S000003983	pathwaymech:catalyzes	WikiPathways:WP392/id8cc08cdf	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP392		"[{""reference_id"": ""WikiPathways:WP392"", ""source_assertion"": ""GPML idd278a2e5 connects normalized SGD:S000003983 as a catalyst of interaction id8cc08cdf."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idd278a2e5']/Graphics; /Pathway/DataNode[@GraphId='bfc']""}]"	"[{""id"": ""WikiPathways:WP392"", ""source_sha256"": ""484f2685c03edd87cecc84c83c4b5f7fdf882fc46d040f3d43a7dd10f1d8ab9e"", ""source_version"": ""WP392_r20261002122028"", ""title"": ""WP392 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP392/WP392.gpml""}]"	""
pathwaymech:WikiPathways_WP392_causal-review-13_ab106af1c8a3	SGD:S000001477	pathwaymech:catalyzes	WikiPathways:WP392/id8cc08cdf	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP392		"[{""reference_id"": ""WikiPathways:WP392"", ""source_assertion"": ""GPML idd278a2e5 connects normalized SGD:S000001477 as a catalyst of interaction id8cc08cdf."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idd278a2e5']/Graphics; /Pathway/DataNode[@GraphId='c00']""}]"	"[{""id"": ""WikiPathways:WP392"", ""source_sha256"": ""484f2685c03edd87cecc84c83c4b5f7fdf882fc46d040f3d43a7dd10f1d8ab9e"", ""source_version"": ""WP392_r20261002122028"", ""title"": ""WP392 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP392/WP392.gpml""}]"	""
pathwaymech:WikiPathways_WP392_causal-review-14_dc86789aa7d4	WikiPathways:WP392/id3206f739	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP392		"[{""reference_id"": ""WikiPathways:WP392"", ""source_assertion"": ""GPML idd919a6a connects normalized CHEBI:58349 as an output of interaction id3206f739."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idd919a6a']/Graphics; /Pathway/DataNode[@GraphId='e4820']""}]"	"[{""id"": ""WikiPathways:WP392"", ""source_sha256"": ""484f2685c03edd87cecc84c83c4b5f7fdf882fc46d040f3d43a7dd10f1d8ab9e"", ""source_version"": ""WP392_r20261002122028"", ""title"": ""WP392 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP392/WP392.gpml""}]"	""
pathwaymech:WikiPathways_WP392_causal-review-15_52f35811119f	CHEBI:16474	pathwaymech:consumes	WikiPathways:WP392/id3206f739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP392	Direction resolved from the source pathway redox description, not an unheaded line alone.	"[{""reference_id"": ""WikiPathways:WP392"", ""source_assertion"": ""GPML id50af4865 connects normalized CHEBI:16474 as an input of interaction id3206f739."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id50af4865']/Graphics; /Pathway/DataNode[@GraphId='fe0']""}]"	"[{""id"": ""WikiPathways:WP392"", ""source_sha256"": ""484f2685c03edd87cecc84c83c4b5f7fdf882fc46d040f3d43a7dd10f1d8ab9e"", ""source_version"": ""WP392_r20261002122028"", ""title"": ""WP392 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP392/WP392.gpml""}]"	""
pathwaymech:WikiPathways_WP392_causal-review-16_941ac36e5342	CHEBI:15378	pathwaymech:consumes	WikiPathways:WP392/id3206f739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP392	Direction resolved from the source pathway redox description, not an unheaded line alone.	"[{""reference_id"": ""WikiPathways:WP392"", ""source_assertion"": ""GPML id50af4865 connects normalized CHEBI:15378 as an input of interaction id3206f739."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id50af4865']/Graphics; /Pathway/DataNode[@GraphId='efa82']""}]"	"[{""id"": ""WikiPathways:WP392"", ""source_sha256"": ""484f2685c03edd87cecc84c83c4b5f7fdf882fc46d040f3d43a7dd10f1d8ab9e"", ""source_version"": ""WP392_r20261002122028"", ""title"": ""WP392 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP392/WP392.gpml""}]"	""
pathwaymech:WikiPathways_WP392_causal-review-17_f513757672e8	CHEBI:16240	pathwaymech:consumes	WikiPathways:WP392/idb13bbbe	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP392	Direction resolved from the source pathway redox description, not an unheaded line alone.	"[{""reference_id"": ""WikiPathways:WP392"", ""source_assertion"": ""GPML id3cdb2e84 connects normalized CHEBI:16240 as an input of interaction idb13bbbe."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id3cdb2e84']/Graphics; /Pathway/DataNode[@GraphId='d804d']""}]"	"[{""id"": ""WikiPathways:WP392"", ""source_sha256"": ""484f2685c03edd87cecc84c83c4b5f7fdf882fc46d040f3d43a7dd10f1d8ab9e"", ""source_version"": ""WP392_r20261002122028"", ""title"": ""WP392 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP392/WP392.gpml""}]"	""
pathwaymech:WikiPathways_WP392_cofactor-4e6bdc0b70d4_e3b51196c729	SGD:S000006012	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41921	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:17554778) Binds 1 FAD per subunit. UniProt note evidence: ECO:0000269 (PubMed:17554778)	"[{""reference_id"": ""UniProtKB:P41921"", ""source_assertion"": ""UniProtKB:P41921 annotates CHEBI:57692 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1831/comments/0/cofactors/0; /results/1831/comments/0/note""}, {""reference_id"": ""UniProtKB:P41921"", ""source_assertion"": ""UniProtKB:P41921 has the exact SGD cross-reference SGD:S000006012."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1831/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P41921"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P41921 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-001_2328ce00b2a0	gomodel:YeastPathways_PWY3O-48/6a4c244800000498	RO:0002234	CHEBI:57597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 RO:0002234 gomodel:YeastPathways_PWY3O-48/6a4c244800000502."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/0; endpoint types: /individuals/45/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-002_96f50eb52212	gomodel:1.1.1.8-RXN	RO:0002234	CHEBI:57597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:1.1.1.8-RXN RO:0002234 gomodel:CHEBI_57597_1.1.1.8-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/1; endpoint types: /individuals/28/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-003_714112a80686	gomodel:1.1.1.8-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:1.1.1.8-RXN BFO:0000066 gomodel:reaction_1.1.1.8-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/2; endpoint types: /individuals/28/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-004_e7d74f805933	gomodel:YeastPathways_PWY3O-48/6a4c244800000498	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 RO:0002233 gomodel:YeastPathways_PWY3O-48/6a4c244800000499."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/3; endpoint types: /individuals/45/type; /individuals/46/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-005_c9434e439df1	gomodel:YeastPathways_PWY3O-48/6a4c244800000498	BFO:0000050	GO:0006114	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 BFO:0000050 gomodel:YeastPathways_PWY3O-48/YeastPathways_PWY3O-48."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/4; endpoint types: /individuals/45/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-006_931b535b4c95	gomodel:GLYCEROL-1-PHOSPHATASE-RXN	RO:0002234	CHEBI:17754	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-1-PHOSPHATASE-RXN RO:0002234 gomodel:CHEBI_17754_GLYCEROL-1-PHOSPHATASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/5; endpoint types: /individuals/9/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-007_a3299f71c154	gomodel:YeastPathways_PWY3O-48/6a4c244800000482	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000482 RO:0002234 gomodel:YeastPathways_PWY3O-48/6a4c244800000486."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/6; endpoint types: /individuals/30/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-008_89cc587d7acd	gomodel:YeastPathways_PWY3O-48/6a4c244800000482	RO:0002234	CHEBI:17754	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000482 RO:0002234 gomodel:YeastPathways_PWY3O-48/6a4c244800000485."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/7; endpoint types: /individuals/30/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-009_3d1d8b289cbf	gomodel:GLYCEROL-1-PHOSPHATASE-RXN	BFO:0000050	GO:0006114	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-1-PHOSPHATASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-48/YeastPathways_PWY3O-48."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/8; endpoint types: /individuals/9/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-010_b4f4d1d111c1	gomodel:YeastPathways_PWY3O-48/6a4c244800000482	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000482 RO:0002233 gomodel:YeastPathways_PWY3O-48/6a4c244800000483."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/9; endpoint types: /individuals/30/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-011_d703c64e0077	gomodel:1.1.1.8-RXN	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:1.1.1.8-RXN RO:0002233 gomodel:CHEBI_57945_1.1.1.8-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/10; endpoint types: /individuals/28/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-012_6803cf4183b2	gomodel:YeastPathways_PWY3O-48/6a4c244800000482	RO:0002233	CHEBI:231935	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000482 RO:0002233 gomodel:YeastPathways_PWY3O-48/6a4c244800000484."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/11; endpoint types: /individuals/30/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-013_10d94286b1ce	SGD:S000002180	pathwaymech:enables	gomodel:1.1.1.8-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:1.1.1.8-RXN RO:0002333 gomodel:YDL022W-MONOMER_1.1.1.8-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/12; endpoint types: /individuals/28/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-014_6261bd535f18	gomodel:GLYCEROL-1-PHOSPHATASE-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-1-PHOSPHATASE-RXN RO:0002234 gomodel:CHEBI_43474_GLYCEROL-1-PHOSPHATASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/13; endpoint types: /individuals/9/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-015_46445339426f	gomodel:YeastPathways_PWY3O-48/6a4c244800000498	RO:0002411	gomodel:YeastPathways_PWY3O-48/6a4c244800000482	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 RO:0002411 gomodel:YeastPathways_PWY3O-48/6a4c244800000482."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/14; endpoint types: /individuals/45/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-016_1e9c4dc6fffa	gomodel:GLYCEROL-1-PHOSPHATASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-1-PHOSPHATASE-RXN RO:0002233 gomodel:CHEBI_15377_GLYCEROL-1-PHOSPHATASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/15; endpoint types: /individuals/9/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-017_3afb1b21159e	gomodel:1.1.1.8-RXN	RO:0002411	gomodel:YeastPathways_PWY3O-48/6a4c244800000482	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:1.1.1.8-RXN RO:0002411 gomodel:YeastPathways_PWY3O-48/6a4c244800000482."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/16; endpoint types: /individuals/28/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-018_1271063ff23a	gomodel:GLYCEROL-1-PHOSPHATASE-RXN	RO:0002233	CHEBI:231935	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-1-PHOSPHATASE-RXN RO:0002233 gomodel:CHEBI_231935_GLYCEROL-1-PHOSPHATASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/17; endpoint types: /individuals/9/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-019_b2321ca0e5c9	gomodel:1.1.1.8-RXN	BFO:0000050	GO:0006114	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:1.1.1.8-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-48/YeastPathways_PWY3O-48."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/18; endpoint types: /individuals/28/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-020_efb0b88dc3e6	gomodel:GLYCEROL-1-PHOSPHATASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-1-PHOSPHATASE-RXN BFO:0000066 gomodel:reaction_GLYCEROL-1-PHOSPHATASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/19; endpoint types: /individuals/9/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-021_4b5a2424014f	gomodel:YeastPathways_PWY3O-48/6a4c244800000498	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 RO:0002234 gomodel:YeastPathways_PWY3O-48/6a4c244800000503."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/20; endpoint types: /individuals/45/type; /individuals/50/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-022_23fc4f6b3c03	gomodel:1.1.1.8-RXN	RO:0002411	gomodel:GLYCEROL-1-PHOSPHATASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:1.1.1.8-RXN RO:0002411 gomodel:GLYCEROL-1-PHOSPHATASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/21; endpoint types: /individuals/28/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-023_13ec92b2f244	gomodel:YeastPathways_PWY3O-48/6a4c244800000498	RO:0002233	CHEBI:57642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 RO:0002233 gomodel:YeastPathways_PWY3O-48/6a4c244800000501."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/22; endpoint types: /individuals/45/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-024_08399422f3c3	gomodel:YeastPathways_PWY3O-48/6a4c244800000498	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 RO:0002233 gomodel:YeastPathways_PWY3O-48/6a4c244800000500."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/23; endpoint types: /individuals/45/type; /individuals/47/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-025_fb1e7caf2beb	gomodel:YeastPathways_PWY3O-48/6a4c244800000482	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000482 BFO:0000066 gomodel:YeastPathways_PWY3O-48/6a4c244800000489."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/24; endpoint types: /individuals/30/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-026_baac5bb72489	gomodel:YeastPathways_PWY3O-48/6a4c244800000482	BFO:0000050	GO:0006114	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000482 BFO:0000050 gomodel:YeastPathways_PWY3O-48/YeastPathways_PWY3O-48."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/25; endpoint types: /individuals/30/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-027_9dd209c2ec08	gomodel:1.1.1.8-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:1.1.1.8-RXN RO:0002233 gomodel:CHEBI_15378_1.1.1.8-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/26; endpoint types: /individuals/28/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-028_8de78e4c9914	gomodel:1.1.1.8-RXN	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:1.1.1.8-RXN RO:0002234 gomodel:CHEBI_57540_1.1.1.8-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/27; endpoint types: /individuals/28/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-029_c68ff741bdd1	gomodel:YeastPathways_PWY3O-48/6a4c244800000498	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 BFO:0000066 gomodel:YeastPathways_PWY3O-48/6a4c244800000506."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/28; endpoint types: /individuals/45/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-030_86fd025641f5	gomodel:1.1.1.8-RXN	RO:0002233	CHEBI:57642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:1.1.1.8-RXN RO:0002233 gomodel:CHEBI_57642_1.1.1.8-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/29; endpoint types: /individuals/28/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-031_3390536f3c13	SGD:S000005420	pathwaymech:enables	gomodel:YeastPathways_PWY3O-48/6a4c244800000498	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 RO:0002333 gomodel:YeastPathways_PWY3O-48/6a4c244800000504."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/30; endpoint types: /individuals/45/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-032_d62f09afc2ad	gomodel:YeastPathways_PWY3O-48/6a4c244800000498	RO:0002411	gomodel:GLYCEROL-1-PHOSPHATASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 RO:0002411 gomodel:GLYCEROL-1-PHOSPHATASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/31; endpoint types: /individuals/45/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-033_6bda2b95553b	SGD:S000001315	pathwaymech:enables	gomodel:GLYCEROL-1-PHOSPHATASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-1-PHOSPHATASE-RXN RO:0002333 gomodel:YIL053W-MONOMER_GLYCEROL-1-PHOSPHATASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/32; endpoint types: /individuals/9/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_edge-034_96d4b4592822	SGD:S000000864	pathwaymech:enables	gomodel:YeastPathways_PWY3O-48/6a4c244800000482	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-48		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000482 RO:0002333 gomodel:YeastPathways_PWY3O-48/6a4c244800000487."", ""source_locator"": ""./YeastPathways_PWY3O-48.json#/facts/33; endpoint types: /individuals/30/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-48"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json"", ""title"": ""SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_location-806bfe23c20b_a9035564b5a4	SGD:S000002180	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q00055	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:15210723)	"[{""reference_id"": ""UniProtKB:Q00055"", ""source_assertion"": ""UniProtKB:Q00055 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2362/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q00055"", ""source_assertion"": ""UniProtKB:Q00055 has the exact SGD cross-reference SGD:S000002180."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2362/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q00055"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q00055 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_location-39ebc920cefa_ee32478f111a	SGD:S000002180	RO:0001025	GO:0005777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q00055	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:15210723)	"[{""reference_id"": ""UniProtKB:Q00055"", ""source_assertion"": ""UniProtKB:Q00055 annotates location Peroxisome (SL-0204)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2362/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q00055"", ""source_assertion"": ""UniProtKB:Q00055 has the exact SGD cross-reference SGD:S000002180."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2362/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q00055"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q00055 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_location-4d73746c3f4d_a7217c1db80b	SGD:S000005420	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41911	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P41911"", ""source_assertion"": ""UniProtKB:P41911 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1828/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P41911"", ""source_assertion"": ""UniProtKB:P41911 has the exact SGD cross-reference SGD:S000005420."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1828/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P41911"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41911 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_location-f948293c7864_69264cdc7cc7	SGD:S000005420	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41911	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P41911"", ""source_assertion"": ""UniProtKB:P41911 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1828/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P41911"", ""source_assertion"": ""UniProtKB:P41911 has the exact SGD cross-reference SGD:S000005420."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1828/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P41911"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41911 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_location-dcf1853a7941_b745936ba72d	SGD:S000001315	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41277	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P41277"", ""source_assertion"": ""UniProtKB:P41277 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1798/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P41277"", ""source_assertion"": ""UniProtKB:P41277 has the exact SGD cross-reference SGD:S000001315."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1798/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P41277"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41277 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_location-34466a2c0a27_2d9ba3718132	SGD:S000001315	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41277	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P41277"", ""source_assertion"": ""UniProtKB:P41277 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1798/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P41277"", ""source_assertion"": ""UniProtKB:P41277 has the exact SGD cross-reference SGD:S000001315."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1798/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P41277"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41277 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_location-aa6dc1a6a1c1_b750b5b80f13	SGD:S000000864	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40106	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P40106"", ""source_assertion"": ""UniProtKB:P40106 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1669/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P40106"", ""source_assertion"": ""UniProtKB:P40106 has the exact SGD cross-reference SGD:S000000864."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1669/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40106"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40106 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_location-6ffb4ceefa77_4d768bc33d4b	SGD:S000000864	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40106	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P40106"", ""source_assertion"": ""UniProtKB:P40106 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1669/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P40106"", ""source_assertion"": ""UniProtKB:P40106 has the exact SGD cross-reference SGD:S000000864."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1669/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40106"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40106 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_cofactor-6c7564e59fad_64a084d3a7e1	SGD:S000001315	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41277	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000305 (PubMed:8662716)	"[{""reference_id"": ""UniProtKB:P41277"", ""source_assertion"": ""UniProtKB:P41277 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1798/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P41277"", ""source_assertion"": ""UniProtKB:P41277 has the exact SGD cross-reference SGD:S000001315."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1798/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P41277"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41277 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-48_cofactor-d1a805ef7369_f598e0c683e5	SGD:S000000864	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40106	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000305 (PubMed:8662716)	"[{""reference_id"": ""UniProtKB:P40106"", ""source_assertion"": ""UniProtKB:P40106 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1669/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P40106"", ""source_assertion"": ""UniProtKB:P40106 has the exact SGD cross-reference SGD:S000000864."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1669/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P40106"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40106 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_GLYCEROLMETAB-PWY_edge-001_d12f986fa3ec	CHEBI:16016	pathwaymech:consumes	RHEA:18382	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18382		"[{""reference_id"": ""RHEA:18382"", ""source_assertion"": ""Rhea lists CHEBI:16016 on the substrates side of RHEA:18382 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18382']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18382"", ""source_version"": ""139"", ""title"": ""Rhea dihydroxyacetone-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18382""}]"	""
pathwaymech:MetaCyc_GLYCEROLMETAB-PWY_edge-002_d6328174f552	CHEBI:58702	pathwaymech:consumes	RHEA:18382	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18382		"[{""reference_id"": ""RHEA:18382"", ""source_assertion"": ""Rhea lists CHEBI:58702 on the substrates side of RHEA:18382 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18382']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18382"", ""source_version"": ""139"", ""title"": ""Rhea dihydroxyacetone-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18382""}]"	""
pathwaymech:MetaCyc_GLYCEROLMETAB-PWY_edge-003_a954645ed642	RHEA:18382	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18382		"[{""reference_id"": ""RHEA:18382"", ""source_assertion"": ""Rhea lists CHEBI:15361 on the products side of RHEA:18382 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18382']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18382"", ""source_version"": ""139"", ""title"": ""Rhea dihydroxyacetone-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18382""}]"	""
pathwaymech:MetaCyc_GLYCEROLMETAB-PWY_edge-004_de3f45847b95	RHEA:18382	pathwaymech:produces	CHEBI:57642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18382		"[{""reference_id"": ""RHEA:18382"", ""source_assertion"": ""Rhea lists CHEBI:57642 on the products side of RHEA:18382 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18382']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18382"", ""source_version"": ""139"", ""title"": ""Rhea dihydroxyacetone-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18382""}]"	""
pathwaymech:MetaCyc_GLYCEROLMETAB-PWY_edge-005_d7209c5a462f	CHEBI:17754	pathwaymech:consumes	RHEA:13770	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13770		"[{""reference_id"": ""RHEA:13770"", ""source_assertion"": ""Rhea lists CHEBI:17754 on the substrates side of RHEA:13770 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13770']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13770"", ""source_version"": ""139"", ""title"": ""RHEA:13770 authority record"", ""url"": ""https://www.rhea-db.org/rhea/13770""}]"	""
pathwaymech:MetaCyc_GLYCEROLMETAB-PWY_edge-006_1e8ff3800124	CHEBI:57540	pathwaymech:consumes	RHEA:13770	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13770		"[{""reference_id"": ""RHEA:13770"", ""source_assertion"": ""Rhea lists CHEBI:57540 on the substrates side of RHEA:13770 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13770']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13770"", ""source_version"": ""139"", ""title"": ""RHEA:13770 authority record"", ""url"": ""https://www.rhea-db.org/rhea/13770""}]"	""
pathwaymech:MetaCyc_GLYCEROLMETAB-PWY_edge-007_2d2007d8f776	RHEA:13770	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13770		"[{""reference_id"": ""RHEA:13770"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:13770 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13770']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13770"", ""source_version"": ""139"", ""title"": ""RHEA:13770 authority record"", ""url"": ""https://www.rhea-db.org/rhea/13770""}]"	""
pathwaymech:MetaCyc_GLYCEROLMETAB-PWY_edge-008_6b5f1563eca3	RHEA:13770	pathwaymech:produces	CHEBI:16016	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13770		"[{""reference_id"": ""RHEA:13770"", ""source_assertion"": ""Rhea lists CHEBI:16016 on the products side of RHEA:13770 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13770']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13770"", ""source_version"": ""139"", ""title"": ""RHEA:13770 authority record"", ""url"": ""https://www.rhea-db.org/rhea/13770""}]"	""
pathwaymech:MetaCyc_GLYCEROLMETAB-PWY_edge-009_07e1325b2861	RHEA:13770	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13770		"[{""reference_id"": ""RHEA:13770"", ""source_assertion"": ""Rhea lists CHEBI:57945 on the products side of RHEA:13770 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13770']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13770"", ""source_version"": ""139"", ""title"": ""RHEA:13770 authority record"", ""url"": ""https://www.rhea-db.org/rhea/13770""}]"	""
pathwaymech:MetaCyc_GLYCEROLMETAB-PWY_edge-010_b65e78f8b1b8	EC:1.1.1.6	pathwaymech:catalyzes	RHEA:13770	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13769		"[{""reference_id"": ""RHEA:13769"", ""source_assertion"": ""Rhea associates EC:1.1.1.6 with the reaction family containing RHEA:13770."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:13769"", ""source_version"": ""139"", ""title"": ""Rhea glycerol dehydrogenase reaction"", ""url"": ""https://www.rhea-db.org/rhea/13769""}]"	""
pathwaymech:MetaCyc_GLYCEROLMETAB-PWY_edge-011_39476817e8f7	EC:2.7.1.121	pathwaymech:catalyzes	RHEA:18382	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18381		"[{""reference_id"": ""RHEA:18381"", ""source_assertion"": ""Rhea associates EC:2.7.1.121 with the reaction family containing RHEA:18382."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:18381"", ""source_version"": ""139"", ""title"": ""Rhea dihydroxyacetone kinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/18381""}]"	""
pathwaymech:MetaCyc_GLYCEROLMETAB-PWY_edge-012_2bd57325ccfd	RHEA:13770	pathwaymech:precedes	RHEA:18382	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLYCEROLMETAB-PWY		"[{""reference_id"": ""MetaCyc:GLYCEROLMETAB-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:13770 before RHEA:18382 in this pathway. Shared intermediate: CHEBI:16016."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GLYCEROLMETAB-PWY"", ""source_sha256"": ""151d0a826a544e5c30a0e1252ff0a8d77fbdc8be3ca220332abc10665936037b"", ""source_version"": ""22.5"", ""title"": ""MetaCyc glycerol degradation V"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLYCEROLMETAB-PWY&detail=full""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-001_357334c659ea	gomodel:GCVT-RXN	RO:0002234	CHEBI:20502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:GCVT-RXN RO:0002234 gomodel:CHEBI_20502_GCVT-RXN."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/0; endpoint types: /individuals/12/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-002_14adc1d1a246	SGD:S000001876	pathwaymech:enables	gomodel:RXN-8629	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-8629 RO:0002333 gomodel:YFL018C-MONOMER_RXN-8629_controller."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/1; endpoint types: /individuals/13/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-003_467cd7ce2d82	gomodel:GCVP-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:GCVP-RXN RO:0002233 gomodel:CHEBI_15378_GCVP-RXN."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/2; endpoint types: /individuals/11/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-004_854259b16289	gomodel:GCVP-RXN	BFO:0000050	GO:0019464	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:GCVP-RXN BFO:0000050 gomodel:YeastPathways_GLYCLEAV-PWY/YeastPathways_GLYCLEAV-PWY."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/3; endpoint types: /individuals/11/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-006_1e82640ac310	gomodel:RXN-8629	RO:0002233	CHEBI:16194	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-8629 RO:0002233 gomodel:CHEBI_16194_GCVT-RXN."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/5; endpoint types: /individuals/13/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-007_edadb1527ff6	gomodel:GCVP-RXN	RO:0002234	CHEBI:16882	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:GCVP-RXN RO:0002234 gomodel:CHEBI_16882_GCVP-RXN."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/6; endpoint types: /individuals/11/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-008_699ce7669cc0	gomodel:RXN-8629	BFO:0000050	GO:0019464	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-8629 BFO:0000050 gomodel:YeastPathways_GLYCLEAV-PWY/YeastPathways_GLYCLEAV-PWY."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/7; endpoint types: /individuals/13/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-009_40ba704a4610	gomodel:RXN-8629	RO:0002234	CHEBI:15804	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-8629 RO:0002234 gomodel:CHEBI_15804_RXN-8629."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/8; endpoint types: /individuals/13/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-010_6dad99e3c59e	gomodel:RXN-8629	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-8629 RO:0002233 gomodel:CHEBI_57540_RXN-8629."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/9; endpoint types: /individuals/13/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-011_bfa8bb7272a1	gomodel:GCVT-RXN	RO:0002234	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:GCVT-RXN RO:0002234 gomodel:CHEBI_28938_GCVT-RXN."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/10; endpoint types: /individuals/12/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-012_f22bf064fd62	gomodel:GCVT-RXN	BFO:0000050	GO:0019464	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:GCVT-RXN BFO:0000050 gomodel:YeastPathways_GLYCLEAV-PWY/YeastPathways_GLYCLEAV-PWY."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/11; endpoint types: /individuals/12/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-014_b9cf610762eb	gomodel:RXN-8629	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-8629 RO:0002234 gomodel:CHEBI_15378_RXN-8629."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/13; endpoint types: /individuals/13/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-015_5180462ac162	gomodel:GCVP-RXN	RO:0002233	CHEBI:15804	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:GCVP-RXN RO:0002233 gomodel:CHEBI_15804_RXN-8629."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/14; endpoint types: /individuals/11/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-016_363d55e17afc	gomodel:GCVT-RXN	RO:0002233	CHEBI:16882	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:GCVT-RXN RO:0002233 gomodel:CHEBI_16882_GCVP-RXN."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/15; endpoint types: /individuals/12/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-017_74a20776b262	gomodel:GCVT-RXN	RO:0002234	CHEBI:16194	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:GCVT-RXN RO:0002234 gomodel:CHEBI_16194_GCVT-RXN."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/16; endpoint types: /individuals/12/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-018_c25a1bd3b29e	gomodel:RXN-8629	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-8629 RO:0002234 gomodel:CHEBI_57945_RXN-8629."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/17; endpoint types: /individuals/13/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-019_857b681906b8	SGD:S000002426	pathwaymech:enables	gomodel:GCVT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:GCVT-RXN RO:0002333 gomodel:YDR019C-MONOMER_GCVT-RXN_controller."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/18; endpoint types: /individuals/12/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-021_65afba10530b	gomodel:GCVP-RXN	RO:0002233	CHEBI:57305	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:GCVP-RXN RO:0002233 gomodel:CHEBI_57305_GCVP-RXN."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/20; endpoint types: /individuals/11/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-022_88361d9245dc	gomodel:GCVT-RXN	RO:0002233	CHEBI:67016	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:GCVT-RXN RO:0002233 gomodel:YeastPathways_GLYCLEAV-PWY/65692e7e00001185."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/21; endpoint types: /individuals/12/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-023_70dff764e0dc	gomodel:GCVP-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:GCVP-RXN RO:0002234 gomodel:CHEBI_16526_GCVP-RXN."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/22; endpoint types: /individuals/11/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_edge-024_c2562c9ed1ed	SGD:S000004801	pathwaymech:enables	gomodel:GCVP-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCLEAV-PWY		"[{""reference_id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_assertion"": ""The model asserts gomodel:GCVP-RXN RO:0002333 gomodel:YMR189W-MONOMER_GCVP-RXN_controller."", ""source_locator"": ""./YeastPathways_GLYCLEAV-PWY.json#/facts/23; endpoint types: /individuals/11/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCLEAV-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_GLYCLEAV-PWY.json"", ""title"": ""GO-CAM glycine cleavage model YeastPathways_GLYCLEAV-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_location-2dcce5c5fdd8_f33bd5ec55fc	SGD:S000001876	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09624	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P09624"", ""source_assertion"": ""UniProtKB:P09624 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/227/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P09624"", ""source_assertion"": ""UniProtKB:P09624 has the exact SGD cross-reference SGD:S000001876."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/227/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P09624"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P09624 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_location-f4502702bb14_cb0082a001d7	SGD:S000002426	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P48015	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P48015"", ""source_assertion"": ""UniProtKB:P48015 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3893/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P48015"", ""source_assertion"": ""UniProtKB:P48015 has the exact SGD cross-reference SGD:S000002426."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3893/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P48015"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P48015 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_location-57647ef400cc_b847d65fc834	SGD:S000004801	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P49095	Physical protein location from reviewed UniProt. ECO:0000250	"[{""reference_id"": ""UniProtKB:P49095"", ""source_assertion"": ""UniProtKB:P49095 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2023/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P49095"", ""source_assertion"": ""UniProtKB:P49095 has the exact SGD cross-reference SGD:S000004801."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2023/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P49095"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P49095 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_cofactor-4fb48c2e1250_fdbc925a0336	SGD:S000001876	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09624	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:9538259); ECO:0000269 (Reference:Ref.13) Binds 1 FAD per subunit. UniProt note evidence: ECO:0000269 (PubMed:9538259); ECO:0000269 (Reference:Ref.13)	"[{""reference_id"": ""UniProtKB:P09624"", ""source_assertion"": ""UniProtKB:P09624 annotates CHEBI:57692 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/227/comments/0/cofactors/0; /results/227/comments/0/note""}, {""reference_id"": ""UniProtKB:P09624"", ""source_assertion"": ""UniProtKB:P09624 has the exact SGD cross-reference SGD:S000001876."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/227/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P09624"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P09624 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCLEAV-PWY_cofactor-0a859255ac59_023a8d8c049f	SGD:S000004801	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P49095	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P49095"", ""source_assertion"": ""UniProtKB:P49095 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2023/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P49095"", ""source_assertion"": ""UniProtKB:P49095 has the exact SGD cross-reference SGD:S000004801."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2023/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P49095"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P49095 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:WikiPathways_WP478_causal-review-1_30dd12c5c08b	CHEBI:24384	pathwaymech:consumes	WikiPathways:WP478/id16beba20	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP478		"[{""reference_id"": ""WikiPathways:WP478"", ""source_assertion"": ""GPML id16beba20 connects normalized CHEBI:24384 as an input of interaction id16beba20."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id16beba20']/Graphics; /Pathway/DataNode[@GraphId='ff246']""}]"	"[{""id"": ""WikiPathways:WP478"", ""source_sha256"": ""c02b28bb6136df307e48c26d6b79ad15acb251555772b64f86715f8333530586"", ""source_version"": ""WP478_r139587"", ""title"": ""WP478 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP478/WP478.gpml""}]"	""
pathwaymech:WikiPathways_WP478_causal-review-2_7122384ba8e8	WikiPathways:WP478/id16beba20	pathwaymech:produces	CHEBI:25140	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP478		"[{""reference_id"": ""WikiPathways:WP478"", ""source_assertion"": ""GPML id16beba20 connects normalized CHEBI:25140 as an output of interaction id16beba20."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id16beba20']/Graphics; /Pathway/DataNode[@GraphId='c16']""}]"	"[{""id"": ""WikiPathways:WP478"", ""source_sha256"": ""c02b28bb6136df307e48c26d6b79ad15acb251555772b64f86715f8333530586"", ""source_version"": ""WP478_r139587"", ""title"": ""WP478 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP478/WP478.gpml""}]"	""
pathwaymech:WikiPathways_WP478_causal-review-3_a48924aefb93	CHEBI:16077	pathwaymech:consumes	WikiPathways:WP478/id5442c585	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP478		"[{""reference_id"": ""WikiPathways:WP478"", ""source_assertion"": ""GPML id5442c585 connects normalized CHEBI:16077 as an input of interaction id5442c585."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5442c585']/Graphics; /Pathway/DataNode[@GraphId='f0d']""}]"	"[{""id"": ""WikiPathways:WP478"", ""source_sha256"": ""c02b28bb6136df307e48c26d6b79ad15acb251555772b64f86715f8333530586"", ""source_version"": ""WP478_r139587"", ""title"": ""WP478 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP478/WP478.gpml""}]"	""
pathwaymech:WikiPathways_WP478_causal-review-4_3a8eaf80b117	WikiPathways:WP478/id5442c585	pathwaymech:produces	CHEBI:4170	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP478		"[{""reference_id"": ""WikiPathways:WP478"", ""source_assertion"": ""GPML id5442c585 connects normalized CHEBI:4170 as an output of interaction id5442c585."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5442c585']/Graphics; /Pathway/DataNode[@GraphId='c69']""}]"	"[{""id"": ""WikiPathways:WP478"", ""source_sha256"": ""c02b28bb6136df307e48c26d6b79ad15acb251555772b64f86715f8333530586"", ""source_version"": ""WP478_r139587"", ""title"": ""WP478 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP478/WP478.gpml""}]"	""
pathwaymech:WikiPathways_WP478_causal-review-5_17ecf49a1fad	CHEBI:43474	pathwaymech:consumes	WikiPathways:WP478/id16beba20	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP478		"[{""reference_id"": ""WikiPathways:WP478"", ""source_assertion"": ""GPML id2d319881 connects normalized CHEBI:43474 as an input of interaction id16beba20."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id2d319881']/Graphics; /Pathway/DataNode[@GraphId='d18']""}]"	"[{""id"": ""WikiPathways:WP478"", ""source_sha256"": ""c02b28bb6136df307e48c26d6b79ad15acb251555772b64f86715f8333530586"", ""source_version"": ""WP478_r139587"", ""title"": ""WP478 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP478/WP478.gpml""}]"	""
pathwaymech:WikiPathways_WP478_causal-review-6_7f31c09c71d7	SGD:S000004711	pathwaymech:catalyzes	WikiPathways:WP478/id5442c585	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP478		"[{""reference_id"": ""WikiPathways:WP478"", ""source_assertion"": ""GPML id62f35795 connects normalized SGD:S000004711 as a catalyst of interaction id5442c585."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id62f35795']/Graphics; /Pathway/DataNode[@GraphId='a35']""}]"	"[{""id"": ""WikiPathways:WP478"", ""source_sha256"": ""c02b28bb6136df307e48c26d6b79ad15acb251555772b64f86715f8333530586"", ""source_version"": ""WP478_r139587"", ""title"": ""WP478 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP478/WP478.gpml""}]"	""
pathwaymech:WikiPathways_WP478_causal-review-7_57972685edcc	SGD:S000001610	pathwaymech:catalyzes	WikiPathways:WP478/id5442c585	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP478		"[{""reference_id"": ""WikiPathways:WP478"", ""source_assertion"": ""GPML id62f35795 connects normalized SGD:S000001610 as a catalyst of interaction id5442c585."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id62f35795']/Graphics; /Pathway/DataNode[@GraphId='d6a']""}]"	"[{""id"": ""WikiPathways:WP478"", ""source_sha256"": ""c02b28bb6136df307e48c26d6b79ad15acb251555772b64f86715f8333530586"", ""source_version"": ""WP478_r139587"", ""title"": ""WP478 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP478/WP478.gpml""}]"	""
pathwaymech:WikiPathways_WP478_causal-review-8_210ef1022400	WikiPathways:WP478/id16beba20	pathwaymech:produces	CHEBI:16077	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP478		"[{""reference_id"": ""WikiPathways:WP478"", ""source_assertion"": ""GPML ida7682afa connects normalized CHEBI:16077 as an output of interaction id16beba20."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ida7682afa']/Graphics; /Pathway/DataNode[@GraphId='f0d']""}]"	"[{""id"": ""WikiPathways:WP478"", ""source_sha256"": ""c02b28bb6136df307e48c26d6b79ad15acb251555772b64f86715f8333530586"", ""source_version"": ""WP478_r139587"", ""title"": ""WP478 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP478/WP478.gpml""}]"	""
pathwaymech:WikiPathways_WP478_causal-review-9_f32741e44e9a	SGD:S000006364	pathwaymech:catalyzes	WikiPathways:WP478/id16beba20	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP478		"[{""reference_id"": ""WikiPathways:WP478"", ""source_assertion"": ""GPML idc3547a63 connects normalized SGD:S000006364 as a catalyst of interaction id16beba20."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idc3547a63']/Graphics; /Pathway/DataNode[@GraphId='ef0']""}]"	"[{""id"": ""WikiPathways:WP478"", ""source_sha256"": ""c02b28bb6136df307e48c26d6b79ad15acb251555772b64f86715f8333530586"", ""source_version"": ""WP478_r139587"", ""title"": ""WP478 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP478/WP478.gpml""}]"	""
pathwaymech:WikiPathways_WP478_cofactor-0945beb9b2eb_24225a412b8f	SGD:S000004711	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37012	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805) Binds 1 magnesium ion per subunit. Can also use Zn(2+) as cofactor. UniProt note evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805)	"[{""reference_id"": ""UniProtKB:P37012"", ""source_assertion"": ""UniProtKB:P37012 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/comments/0/cofactors/0; /results/1251/comments/0/note""}, {""reference_id"": ""UniProtKB:P37012"", ""source_assertion"": ""UniProtKB:P37012 has the exact SGD cross-reference SGD:S000004711."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P37012"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P37012 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP478_cofactor-02ad2260b7d9_cd7063b3eb35	SGD:S000004711	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37012	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805) Binds 1 magnesium ion per subunit. Can also use Zn(2+) as cofactor. UniProt note evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805)	"[{""reference_id"": ""UniProtKB:P37012"", ""source_assertion"": ""UniProtKB:P37012 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/comments/0/cofactors/1; /results/1251/comments/0/note""}, {""reference_id"": ""UniProtKB:P37012"", ""source_assertion"": ""UniProtKB:P37012 has the exact SGD cross-reference SGD:S000004711."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P37012"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P37012 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP478_cofactor-ad9ff5447ab5_0a6570466bf9	SGD:S000001610	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33401	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00949) Binds 1 Mg(2+) ion per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00949)	"[{""reference_id"": ""UniProtKB:P33401"", ""source_assertion"": ""UniProtKB:P33401 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1085/comments/0/cofactors/0; /results/1085/comments/0/note""}, {""reference_id"": ""UniProtKB:P33401"", ""source_assertion"": ""UniProtKB:P33401 has the exact SGD cross-reference SGD:S000001610."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1085/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P33401"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P33401 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP478_cofactor-ad95e9a0746f_97eace2e93fe	SGD:S000006364	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06738	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P06738"", ""source_assertion"": ""UniProtKB:P06738 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/139/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P06738"", ""source_assertion"": ""UniProtKB:P06738 has the exact SGD cross-reference SGD:S000006364."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/139/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P06738"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P06738 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-001_32968ab9643d	gomodel:F16ALDOLASE-RXN	RO:0002413	gomodel:TRIOSEPISOMERIZATION-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:F16ALDOLASE-RXN RO:0002413 gomodel:TRIOSEPISOMERIZATION-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/0; endpoint types: /individuals/28/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-002_e89974017d66	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579 BFO:0000066 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004587."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/1; endpoint types: /individuals/124/type; /individuals/130/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-003_cee2012ccc77	SGD:S000001635	pathwaymech:enables	gomodel:RXN-15513	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:RXN-15513 RO:0002333 gomodel:YKL152C-MONOMER_RXN-15513_controller."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/2; endpoint types: /individuals/34/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-004_9c97d3cf0d64	gomodel:2PGADEHYDRAT-RXN	RO:0002234	CHEBI:58702	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:2PGADEHYDRAT-RXN RO:0002234 gomodel:CHEBI_58702_2PGADEHYDRAT-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/3; endpoint types: /individuals/110/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-005_7e7b8f28c800	gomodel:F16ALDOLASE-RXN	RO:0002413	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:F16ALDOLASE-RXN RO:0002413 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/4; endpoint types: /individuals/28/type; /individuals/143/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-006_363d8bb3f992	gomodel:RXN-15513	BFO:0000050	GO:0061620	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:RXN-15513 BFO:0000050 gomodel:YeastPathways_GLYCOLYSIS/YeastPathways_GLYCOLYSIS."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/5; endpoint types: /individuals/34/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-007_7188c054133f	gomodel:2PGADEHYDRAT-RXN	BFO:0000050	GO:0061620	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:2PGADEHYDRAT-RXN BFO:0000050 gomodel:YeastPathways_GLYCOLYSIS/YeastPathways_GLYCOLYSIS."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/6; endpoint types: /individuals/110/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-008_8f93e2837cfa	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606 RO:0002233 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004607."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/7; endpoint types: /individuals/143/type; /individuals/144/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-009_41efae3d7892	SGD:S000004369	pathwaymech:enables	gomodel:F16BDEPHOS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:F16BDEPHOS-RXN RO:0002333 gomodel:YLR377C-MONOMER_F16BDEPHOS-RXN_controller."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/8; endpoint types: /individuals/29/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-010_c749b8f811c0	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579	RO:0002233	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579 RO:0002233 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004581."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/9; endpoint types: /individuals/124/type; /individuals/126/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-011_0fa3596e94d5	gomodel:2PGADEHYDRAT-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:2PGADEHYDRAT-RXN BFO:0000066 gomodel:reaction_2PGADEHYDRAT-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/10; endpoint types: /individuals/110/type; /individuals/100/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-012_ee68f729035c	gomodel:6PFRUCTPHOS-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:6PFRUCTPHOS-RXN RO:0002234 gomodel:CHEBI_456216_6PFRUCTPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/11; endpoint types: /individuals/111/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-013_81c299caab54	gomodel:PHOSGLYPHOS-RXN	RO:0002234	CHEBI:58272	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002234 gomodel:CHEBI_58272_PHOSGLYPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/12; endpoint types: /individuals/33/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-014_7ec67a06b8d5	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636	RO:0002233	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636 RO:0002233 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004638."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/13; endpoint types: /individuals/171/type; /individuals/173/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-015_b49447243d7e	SGD:S000000605	pathwaymech:enables	gomodel:PHOSGLYPHOS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002333 gomodel:YCR012W-MONOMER_PHOSGLYPHOS-RXN_controller."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/14; endpoint types: /individuals/33/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-016_aa5abb7cb67c	gomodel:PHOSGLYPHOS-RXN	RO:0002233	CHEBI:57604	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002233 gomodel:CHEBI_57604_GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/15; endpoint types: /individuals/33/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-017_025c8ed2b88f	gomodel:F16BDEPHOS-RXN	RO:0002413	gomodel:6PFRUCTPHOS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:F16BDEPHOS-RXN RO:0002413 gomodel:6PFRUCTPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/16; endpoint types: /individuals/29/type; /individuals/111/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-018_b7050275c6f7	gomodel:PGLUCISOM-RXN	BFO:0000050	GO:0061620	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PGLUCISOM-RXN BFO:0000050 gomodel:YeastPathways_GLYCOLYSIS/YeastPathways_GLYCOLYSIS."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/17; endpoint types: /individuals/32/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-019_a98348bc6907	gomodel:GAPOXNPHOSPHN-RXN	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002233 gomodel:CHEBI_57540_GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/18; endpoint types: /individuals/30/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-020_a6fa013a14ca	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606	BFO:0000050	GO:0061620	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606 BFO:0000050 gomodel:YeastPathways_GLYCOLYSIS/YeastPathways_GLYCOLYSIS."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/19; endpoint types: /individuals/143/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-021_5d614802897e	SGD:S000218025	pathwaymech:enables	gomodel:6PFRUCTPHOS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:6PFRUCTPHOS-RXN RO:0002333 gomodel:YeastPathways_GLYCOLYSIS/6690711d00000315."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/20; endpoint types: /individuals/111/type; /individuals/192/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-022_3ea07b00ad8a	gomodel:TRIOSEPISOMERIZATION-RXN	RO:0002413	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:TRIOSEPISOMERIZATION-RXN RO:0002413 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/21; endpoint types: /individuals/35/type; /individuals/124/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-023_8463c2fee580	gomodel:6PFRUCTPHOS-RXN	BFO:0000050	GO:0061620	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:6PFRUCTPHOS-RXN BFO:0000050 gomodel:YeastPathways_GLYCOLYSIS/YeastPathways_GLYCOLYSIS."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/22; endpoint types: /individuals/111/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-024_f9c18c418b1a	SGD:S000000400	pathwaymech:enables	gomodel:PGLUCISOM-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PGLUCISOM-RXN RO:0002333 gomodel:YBR196C-MONOMER_PGLUCISOM-RXN_controller."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/23; endpoint types: /individuals/32/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-025_6ae156f8c357	gomodel:PHOSGLYPHOS-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PHOSGLYPHOS-RXN BFO:0000066 gomodel:reaction_PHOSGLYPHOS-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/24; endpoint types: /individuals/33/type; /individuals/107/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-026_037917f844cb	SGD:S000005874	pathwaymech:enables	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636 RO:0002333 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004641."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/25; endpoint types: /individuals/171/type; /individuals/176/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-027_0e4cc7dd0601	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004626	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004626 BFO:0000066 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004631."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/26; endpoint types: /individuals/162/type; /individuals/166/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-028_fc69b5b689a3	gomodel:2PGADEHYDRAT-RXN	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:2PGADEHYDRAT-RXN RO:0002234 gomodel:CHEBI_15377_2PGADEHYDRAT-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/27; endpoint types: /individuals/110/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-029_31e7b37d2bb2	gomodel:F16ALDOLASE-RXN	RO:0002234	CHEBI:57642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:F16ALDOLASE-RXN RO:0002234 gomodel:CHEBI_57642_F16ALDOLASE-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/28; endpoint types: /individuals/28/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-030_a30ef7e304ef	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636	RO:0002234	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636 RO:0002234 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004639."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/29; endpoint types: /individuals/171/type; /individuals/174/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-031_06152fb22173	gomodel:F16BDEPHOS-RXN	BFO:0000050	GO:0061620	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:F16BDEPHOS-RXN BFO:0000050 gomodel:YeastPathways_GLYCOLYSIS/YeastPathways_GLYCOLYSIS."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/30; endpoint types: /individuals/29/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-032_8e138a593f7d	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004626	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004626 RO:0002234 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004628."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/31; endpoint types: /individuals/162/type; /individuals/164/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-033_077287d709df	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579	RO:0002234	CHEBI:57604	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579 RO:0002234 gomodel:CHEBI_57604_GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/32; endpoint types: /individuals/124/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-034_21aaa2219ffa	gomodel:PEPDEPHOS-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PEPDEPHOS-RXN BFO:0000066 gomodel:reaction_PEPDEPHOS-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/33; endpoint types: /individuals/31/type; /individuals/105/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-035_b1f09212a765	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636 BFO:0000066 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004643."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/34; endpoint types: /individuals/171/type; /individuals/177/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-036_783a90d94097	gomodel:F16ALDOLASE-RXN	RO:0002233	CHEBI:32966	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:F16ALDOLASE-RXN RO:0002233 gomodel:CHEBI_32966_6PFRUCTPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/35; endpoint types: /individuals/28/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-037_9684083a2bf4	gomodel:PEPDEPHOS-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PEPDEPHOS-RXN RO:0002233 gomodel:CHEBI_15378_PEPDEPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/36; endpoint types: /individuals/31/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-038_7dd7c7edc96c	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636	RO:0002234	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636 RO:0002234 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004640."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/37; endpoint types: /individuals/171/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-039_3977b0f61ba6	gomodel:TRIOSEPISOMERIZATION-RXN	BFO:0000050	GO:0061620	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:TRIOSEPISOMERIZATION-RXN BFO:0000050 gomodel:YeastPathways_GLYCOLYSIS/YeastPathways_GLYCOLYSIS."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/38; endpoint types: /individuals/35/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-040_df46462d49aa	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579 RO:0002233 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004580."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/39; endpoint types: /individuals/124/type; /individuals/125/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-041_09703b6684fb	SGD:S000001543	pathwaymech:enables	gomodel:F16ALDOLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:F16ALDOLASE-RXN RO:0002333 gomodel:YKL060C-MONOMER_F16ALDOLASE-RXN_controller."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/40; endpoint types: /individuals/28/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-042_0614c375b99e	gomodel:TRIOSEPISOMERIZATION-RXN	RO:0002234	CHEBI:59776	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:TRIOSEPISOMERIZATION-RXN RO:0002234 gomodel:CHEBI_59776_TRIOSEPISOMERIZATION-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/41; endpoint types: /individuals/35/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-043_850b2178291e	gomodel:PHOSGLYPHOS-RXN	RO:0002234	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002234 gomodel:CHEBI_30616_PHOSGLYPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/42; endpoint types: /individuals/33/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-044_aa89491d0138	gomodel:PEPDEPHOS-RXN	RO:0002234	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PEPDEPHOS-RXN RO:0002234 gomodel:CHEBI_15361_PEPDEPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/43; endpoint types: /individuals/31/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-045_e29e7e988785	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004626	RO:0002413	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004626 RO:0002413 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/44; endpoint types: /individuals/162/type; /individuals/171/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-046_a539c98a81a6	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636 RO:0002233 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004637."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/45; endpoint types: /individuals/171/type; /individuals/172/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-047_f1d6ecb24a27	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579	BFO:0000050	GO:0061620	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579 BFO:0000050 gomodel:YeastPathways_GLYCOLYSIS/YeastPathways_GLYCOLYSIS."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/46; endpoint types: /individuals/124/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-048_0dcec4fb8a78	gomodel:F16ALDOLASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:F16ALDOLASE-RXN BFO:0000066 gomodel:reaction_F16ALDOLASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/47; endpoint types: /individuals/28/type; /individuals/102/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-049_46d1db651d22	gomodel:PHOSGLYPHOS-RXN	BFO:0000050	GO:0061620	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PHOSGLYPHOS-RXN BFO:0000050 gomodel:YeastPathways_GLYCOLYSIS/YeastPathways_GLYCOLYSIS."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/48; endpoint types: /individuals/33/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-050_51e2140e985b	gomodel:6PFRUCTPHOS-RXN	RO:0002234	CHEBI:32966	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:6PFRUCTPHOS-RXN RO:0002234 gomodel:CHEBI_32966_6PFRUCTPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/49; endpoint types: /individuals/111/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-051_20389eb3ef4a	gomodel:GAPOXNPHOSPHN-RXN	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002234 gomodel:CHEBI_57945_GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/50; endpoint types: /individuals/30/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-052_259d4a259144	gomodel:6PFRUCTPHOS-RXN	RO:0002413	gomodel:F16ALDOLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:6PFRUCTPHOS-RXN RO:0002413 gomodel:F16ALDOLASE-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/51; endpoint types: /individuals/111/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-053_fea8789905e5	gomodel:F16ALDOLASE-RXN	RO:0002413	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:F16ALDOLASE-RXN RO:0002413 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/52; endpoint types: /individuals/28/type; /individuals/124/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-054_1f4553c59060	gomodel:F16BDEPHOS-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:F16BDEPHOS-RXN RO:0002233 gomodel:CHEBI_15377_F16BDEPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/53; endpoint types: /individuals/29/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-055_2af5711862cf	gomodel:6PFRUCTPHOS-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:6PFRUCTPHOS-RXN RO:0002234 gomodel:CHEBI_15378_6PFRUCTPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/54; endpoint types: /individuals/111/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-056_37061a2bb5a4	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004626	RO:0002234	CHEBI:58702	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004626 RO:0002234 gomodel:CHEBI_58702_2PGADEHYDRAT-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/55; endpoint types: /individuals/162/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-057_9bf09bbaa416	gomodel:GAPOXNPHOSPHN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN BFO:0000066 gomodel:reaction_GAPOXNPHOSPHN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/56; endpoint types: /individuals/30/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-058_210c469246f5	gomodel:TRIOSEPISOMERIZATION-RXN	RO:0002413	gomodel:GAPOXNPHOSPHN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:TRIOSEPISOMERIZATION-RXN RO:0002413 gomodel:GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/57; endpoint types: /individuals/35/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-059_59842558b892	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606	RO:0002413	gomodel:PHOSGLYPHOS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606 RO:0002413 gomodel:PHOSGLYPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/58; endpoint types: /individuals/143/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-060_d384ef793fac	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004626	RO:0002233	CHEBI:58289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004626 RO:0002233 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004627."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/59; endpoint types: /individuals/162/type; /individuals/163/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-061_2a1b6c3159d4	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606	RO:0002233	CHEBI:59776	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606 RO:0002233 gomodel:CHEBI_59776_TRIOSEPISOMERIZATION-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/60; endpoint types: /individuals/143/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-062_cb6dca4edf35	gomodel:GAPOXNPHOSPHN-RXN	RO:0002234	CHEBI:57604	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002234 gomodel:CHEBI_57604_GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/61; endpoint types: /individuals/30/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-063_ffe7b80bf9cd	gomodel:6PFRUCTPHOS-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:6PFRUCTPHOS-RXN BFO:0000066 gomodel:reaction_6PFRUCTPHOS-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/62; endpoint types: /individuals/111/type; /individuals/101/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-064_50ce4e84c450	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606	RO:0002233	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606 RO:0002233 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004608."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/63; endpoint types: /individuals/143/type; /individuals/145/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-065_33a65d934ee7	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579 RO:0002234 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004583."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/64; endpoint types: /individuals/124/type; /individuals/128/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-066_2968afe59cae	gomodel:F16BDEPHOS-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:F16BDEPHOS-RXN RO:0002234 gomodel:CHEBI_43474_F16BDEPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/65; endpoint types: /individuals/29/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-067_8bf3146de1ad	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606	RO:0002234	CHEBI:57604	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606 RO:0002234 gomodel:CHEBI_57604_GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/66; endpoint types: /individuals/143/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-068_f6328c29d183	gomodel:PEPDEPHOS-RXN	RO:0002233	CHEBI:58702	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PEPDEPHOS-RXN RO:0002233 gomodel:CHEBI_58702_2PGADEHYDRAT-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/67; endpoint types: /individuals/31/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-069_202c68b89478	gomodel:PGLUCISOM-RXN	RO:0002233	CHEBI:4170	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PGLUCISOM-RXN RO:0002233 gomodel:CHEBI_4170_PGLUCISOM-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/68; endpoint types: /individuals/32/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-070_3ef7786b5f6f	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004626	BFO:0000050	GO:0061620	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004626 BFO:0000050 gomodel:YeastPathways_GLYCOLYSIS/YeastPathways_GLYCOLYSIS."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/69; endpoint types: /individuals/162/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-071_3958a36f8e06	gomodel:PGLUCISOM-RXN	RO:0002413	gomodel:6PFRUCTPHOS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PGLUCISOM-RXN RO:0002413 gomodel:6PFRUCTPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/70; endpoint types: /individuals/32/type; /individuals/111/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-072_c66720443266	gomodel:RXN-15513	RO:0002413	gomodel:2PGADEHYDRAT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:RXN-15513 RO:0002413 gomodel:2PGADEHYDRAT-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/71; endpoint types: /individuals/34/type; /individuals/110/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-073_bb5862082512	gomodel:GAPOXNPHOSPHN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002234 gomodel:CHEBI_15378_GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/72; endpoint types: /individuals/30/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-074_84342ceaea5d	gomodel:F16ALDOLASE-RXN	RO:0002234	CHEBI:59776	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:F16ALDOLASE-RXN RO:0002234 gomodel:CHEBI_59776_F16ALDOLASE-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/73; endpoint types: /individuals/28/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-075_2f626d823830	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606 RO:0002234 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004610."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/74; endpoint types: /individuals/143/type; /individuals/147/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-076_59b1ff99d5cd	gomodel:GAPOXNPHOSPHN-RXN	BFO:0000050	GO:0061620	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN BFO:0000050 gomodel:YeastPathways_GLYCOLYSIS/YeastPathways_GLYCOLYSIS."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/75; endpoint types: /individuals/30/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-077_def547a19c7b	gomodel:PEPDEPHOS-RXN	RO:0002234	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PEPDEPHOS-RXN RO:0002234 gomodel:CHEBI_30616_PEPDEPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/76; endpoint types: /individuals/31/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-078_b58a52b382ab	gomodel:PHOSGLYPHOS-RXN	RO:0002413	gomodel:RXN-15513	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002413 gomodel:RXN-15513."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/77; endpoint types: /individuals/33/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-079_d2025f61a3cd	gomodel:6PFRUCTPHOS-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:6PFRUCTPHOS-RXN RO:0002233 gomodel:CHEBI_30616_6PFRUCTPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/78; endpoint types: /individuals/111/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-080_97e0083f818f	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606 RO:0002234 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004609."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/79; endpoint types: /individuals/143/type; /individuals/146/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-081_3e49083cbaca	gomodel:2PGADEHYDRAT-RXN	RO:0002233	CHEBI:58289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:2PGADEHYDRAT-RXN RO:0002233 gomodel:CHEBI_58289_3PGAREARR-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/80; endpoint types: /individuals/110/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-082_44279ee5ddeb	gomodel:RXN-15513	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:RXN-15513 BFO:0000066 gomodel:reaction_RXN-15513_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/81; endpoint types: /individuals/34/type; /individuals/108/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-083_2a27454b1bbe	gomodel:6PFRUCTPHOS-RXN	RO:0002413	gomodel:F16BDEPHOS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:6PFRUCTPHOS-RXN RO:0002413 gomodel:F16BDEPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/82; endpoint types: /individuals/111/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-084_78aa0f73d09b	SGD:S000003486	pathwaymech:enables	gomodel:2PGADEHYDRAT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:2PGADEHYDRAT-RXN RO:0002333 gomodel:YGR254W-MONOMER_2PGADEHYDRAT-RXN_controller."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/83; endpoint types: /individuals/110/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-085_4757ab1ed3fc	gomodel:RXN-15513	RO:0002234	CHEBI:58289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:RXN-15513 RO:0002234 gomodel:CHEBI_58289_RXN-15513."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/84; endpoint types: /individuals/34/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-086_91e4aa26cf05	gomodel:PEPDEPHOS-RXN	RO:0002233	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PEPDEPHOS-RXN RO:0002233 gomodel:CHEBI_456216_PEPDEPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/85; endpoint types: /individuals/31/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-087_c2ae35865909	gomodel:F16BDEPHOS-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:F16BDEPHOS-RXN BFO:0000066 gomodel:reaction_F16BDEPHOS-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/86; endpoint types: /individuals/29/type; /individuals/103/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-088_cb0aa269fb5c	gomodel:F16BDEPHOS-RXN	RO:0002233	CHEBI:32966	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:F16BDEPHOS-RXN RO:0002233 gomodel:CHEBI_32966_6PFRUCTPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/87; endpoint types: /individuals/29/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-089_a0b12e777bdf	gomodel:6PFRUCTPHOS-RXN	RO:0002233	CHEBI:57634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:6PFRUCTPHOS-RXN RO:0002233 gomodel:CHEBI_57634_F16BDEPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/88; endpoint types: /individuals/111/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-090_42128aa443a7	gomodel:2PGADEHYDRAT-RXN	RO:0002413	gomodel:PEPDEPHOS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:2PGADEHYDRAT-RXN RO:0002413 gomodel:PEPDEPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/89; endpoint types: /individuals/110/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-091_be6a8506ad71	SGD:S000003588	pathwaymech:enables	gomodel:GAPOXNPHOSPHN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002333 gomodel:YJL052W-MONOMER_GAPOXNPHOSPHN-RXN_controller."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/90; endpoint types: /individuals/30/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-092_2614a7927e5e	gomodel:PGLUCISOM-RXN	RO:0002234	CHEBI:57634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PGLUCISOM-RXN RO:0002234 gomodel:CHEBI_57634_PGLUCISOM-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/91; endpoint types: /individuals/32/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-093_3cb8e878220d	SGD:S000003769	pathwaymech:enables	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579 RO:0002333 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004586."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/92; endpoint types: /individuals/124/type; /individuals/129/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-094_497565a533d4	gomodel:PGLUCISOM-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PGLUCISOM-RXN BFO:0000066 gomodel:reaction_PGLUCISOM-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/93; endpoint types: /individuals/32/type; /individuals/106/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-095_dd1be294f587	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579	RO:0002233	CHEBI:59776	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579 RO:0002233 gomodel:CHEBI_59776_TRIOSEPISOMERIZATION-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/94; endpoint types: /individuals/124/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-096_a99d55590459	SGD:S000002457	pathwaymech:enables	gomodel:TRIOSEPISOMERIZATION-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:TRIOSEPISOMERIZATION-RXN RO:0002333 gomodel:YDR050C-MONOMER_TRIOSEPISOMERIZATION-RXN_controller."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/95; endpoint types: /individuals/35/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-097_2e1621c8a895	gomodel:RXN-15513	RO:0002233	CHEBI:58272	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:RXN-15513 RO:0002233 gomodel:CHEBI_58272_PHOSGLYPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/96; endpoint types: /individuals/34/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-098_f3993f1ce635	gomodel:GAPOXNPHOSPHN-RXN	RO:0002413	gomodel:PHOSGLYPHOS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002413 gomodel:PHOSGLYPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/97; endpoint types: /individuals/30/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-099_89bd4b1ce2c0	gomodel:F16ALDOLASE-RXN	RO:0002413	gomodel:GAPOXNPHOSPHN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:F16ALDOLASE-RXN RO:0002413 gomodel:GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/98; endpoint types: /individuals/28/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-100_383cffc02cde	gomodel:TRIOSEPISOMERIZATION-RXN	RO:0002413	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:TRIOSEPISOMERIZATION-RXN RO:0002413 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/99; endpoint types: /individuals/35/type; /individuals/143/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-101_0e0d83faf7f0	gomodel:TRIOSEPISOMERIZATION-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:TRIOSEPISOMERIZATION-RXN BFO:0000066 gomodel:reaction_TRIOSEPISOMERIZATION-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/100; endpoint types: /individuals/35/type; /individuals/109/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-102_1b2005dba1da	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579 RO:0002234 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004582."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/101; endpoint types: /individuals/124/type; /individuals/127/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-103_4a8a73f1193e	gomodel:GAPOXNPHOSPHN-RXN	RO:0002233	CHEBI:59776	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002233 gomodel:CHEBI_59776_TRIOSEPISOMERIZATION-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/102; endpoint types: /individuals/30/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-104_605b5ee8d619	gomodel:PEPDEPHOS-RXN	BFO:0000050	GO:0061620	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PEPDEPHOS-RXN BFO:0000050 gomodel:YeastPathways_GLYCOLYSIS/YeastPathways_GLYCOLYSIS."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/103; endpoint types: /individuals/31/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-105_d2ade233d69b	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579	RO:0002413	gomodel:PHOSGLYPHOS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004579 RO:0002413 gomodel:PHOSGLYPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/104; endpoint types: /individuals/124/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-106_beb0ce4fceed	SGD:S000003424	pathwaymech:enables	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606 RO:0002333 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004611."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/105; endpoint types: /individuals/143/type; /individuals/148/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-107_053764c8285f	gomodel:2PGADEHYDRAT-RXN	RO:0002413	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:2PGADEHYDRAT-RXN RO:0002413 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/106; endpoint types: /individuals/110/type; /individuals/171/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-108_e05ccd9c28e7	gomodel:TRIOSEPISOMERIZATION-RXN	RO:0002233	CHEBI:57642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:TRIOSEPISOMERIZATION-RXN RO:0002233 gomodel:CHEBI_57642_F16ALDOLASE-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/107; endpoint types: /individuals/35/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-109_0685c4b12c40	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004626	RO:0002413	gomodel:PEPDEPHOS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004626 RO:0002413 gomodel:PEPDEPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/108; endpoint types: /individuals/162/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-110_1ab92e0f7221	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004606 BFO:0000066 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004613."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/109; endpoint types: /individuals/143/type; /individuals/149/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-111_fdbc4ac77404	gomodel:RXN-15513	RO:0002413	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004626	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:RXN-15513 RO:0002413 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004626."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/110; endpoint types: /individuals/34/type; /individuals/162/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-112_c149067a175e	gomodel:F16ALDOLASE-RXN	BFO:0000050	GO:0061620	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:F16ALDOLASE-RXN BFO:0000050 gomodel:YeastPathways_GLYCOLYSIS/YeastPathways_GLYCOLYSIS."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/111; endpoint types: /individuals/28/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-113_8a83c75ee3fe	SGD:S000000036	pathwaymech:enables	gomodel:PEPDEPHOS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PEPDEPHOS-RXN RO:0002333 gomodel:YAL038W-MONOMER_PEPDEPHOS-RXN_controller."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/112; endpoint types: /individuals/31/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-114_c60947809def	SGD:S000001217	pathwaymech:enables	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004626	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004626 RO:0002333 gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004629."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/113; endpoint types: /individuals/162/type; /individuals/165/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-115_f75a4c165336	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636	BFO:0000050	GO:0061620	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636 BFO:0000050 gomodel:YeastPathways_GLYCOLYSIS/YeastPathways_GLYCOLYSIS."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/114; endpoint types: /individuals/171/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-116_057d547ea40b	gomodel:GAPOXNPHOSPHN-RXN	RO:0002233	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002233 gomodel:CHEBI_43474_GAPOXNPHOSPHN-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/115; endpoint types: /individuals/30/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-117_f3c636bd9377	gomodel:F16BDEPHOS-RXN	RO:0002234	CHEBI:57634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:F16BDEPHOS-RXN RO:0002234 gomodel:CHEBI_57634_F16BDEPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/116; endpoint types: /individuals/29/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-118_c60b1e19b1ee	gomodel:PHOSGLYPHOS-RXN	RO:0002233	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002233 gomodel:CHEBI_456216_PHOSGLYPHOS-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/117; endpoint types: /individuals/33/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_edge-119_ce642daa1390	gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636	RO:0002233	CHEBI:58702	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_GLYCOLYSIS		"[{""reference_id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_GLYCOLYSIS/6a4c244800004636 RO:0002233 gomodel:CHEBI_58702_2PGADEHYDRAT-RXN."", ""source_locator"": ""./YeastPathways_GLYCOLYSIS.json#/facts/118; endpoint types: /individuals/171/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_GLYCOLYSIS"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-30; member ./YeastPathways_GLYCOLYSIS.json"", ""title"": ""SGD GO-CAM glycolysis I (from glucose 6-phosphate) model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_complex-0e66a709b1dc_b008ea5ce0f1	SGD:S000218025	BFO:0000051	UniProtKB:P16861	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000218025	ECO:0000353: physical interaction evidence; source stoichiometry minValue: 4, maxValue: 4	"[{""reference_id"": ""SGD:S000218025"", ""source_assertion"": ""Complex Portal CPX-554 lists P16861 as a protein component; complex evidence is ECO:0000353: physical interaction evidence."", ""source_locator"": ""Complex Portal JSON #/participants/0; /evidenceType""}]"	"[{""id"": ""SGD:S000218025"", ""source_sha256"": ""4130cfeb17d1011efc4f6a93eb099ea12450c28494be15b9e80890d705e382fb"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-554: 6-phosphofructokinase complex"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-554""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_complex-d1bda1bd271e_6b069289a28c	SGD:S000218025	BFO:0000051	UniProtKB:P16862	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000218025	ECO:0000353: physical interaction evidence; source stoichiometry minValue: 4, maxValue: 4	"[{""reference_id"": ""SGD:S000218025"", ""source_assertion"": ""Complex Portal CPX-554 lists P16862 as a protein component; complex evidence is ECO:0000353: physical interaction evidence."", ""source_locator"": ""Complex Portal JSON #/participants/1; /evidenceType""}]"	"[{""id"": ""SGD:S000218025"", ""source_sha256"": ""4130cfeb17d1011efc4f6a93eb099ea12450c28494be15b9e80890d705e382fb"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-554: 6-phosphofructokinase complex"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-554""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_location-995a2bd5427a_00f614392366	SGD:S000001635	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00950	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P00950"", ""source_assertion"": ""UniProtKB:P00950 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/51/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00950"", ""source_assertion"": ""UniProtKB:P00950 has the exact SGD cross-reference SGD:S000001635."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/51/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00950"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00950 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_location-9e0c57d7a56f_3660c4a9f253	SGD:S000001635	RO:0001025	GO:0005741	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00950	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961); ECO:0000269 (PubMed:16962558) Topology: Peripheral membrane protein. Orientation: Cytoplasmic side.	"[{""reference_id"": ""UniProtKB:P00950"", ""source_assertion"": ""UniProtKB:P00950 annotates location Mitochondrion outer membrane (SL-0172)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/51/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00950"", ""source_assertion"": ""UniProtKB:P00950 has the exact SGD cross-reference SGD:S000001635."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/51/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00950"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00950 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_location-3f0bc85a8101_6f8cfd7b5571	SGD:S000001635	RO:0001025	GO:0005758	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00950	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:22984289)	"[{""reference_id"": ""UniProtKB:P00950"", ""source_assertion"": ""UniProtKB:P00950 annotates location Mitochondrion intermembrane space (SL-0169)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/51/comments/1/subcellularLocations/2; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00950"", ""source_assertion"": ""UniProtKB:P00950 has the exact SGD cross-reference SGD:S000001635."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/51/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00950"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00950 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_location-d86060e3e797_dbb031acf887	SGD:S000000605	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00560	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11502169)	"[{""reference_id"": ""UniProtKB:P00560"", ""source_assertion"": ""UniProtKB:P00560 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/35/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00560"", ""source_assertion"": ""UniProtKB:P00560 has the exact SGD cross-reference SGD:S000000605."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/35/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00560"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00560 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_location-055d2285e273_78b543d9552a	SGD:S000000605	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00560	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961)	"[{""reference_id"": ""UniProtKB:P00560"", ""source_assertion"": ""UniProtKB:P00560 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/35/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00560"", ""source_assertion"": ""UniProtKB:P00560 has the exact SGD cross-reference SGD:S000000605."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/35/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00560"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00560 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_location-94ccb8db9154_558b14e72f6e	SGD:S000000400	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P12709	Physical protein location from reviewed UniProt. ECO:0000250 (UniProtKB:P78917)	"[{""reference_id"": ""UniProtKB:P12709"", ""source_assertion"": ""UniProtKB:P12709 annotates location Cytoplasm, cytosol (SL-0091)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/351/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P12709"", ""source_assertion"": ""UniProtKB:P12709 has the exact SGD cross-reference SGD:S000000400."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/351/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P12709"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P12709 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_location-96a7adf0b4a0_199ca019056d	SGD:S000003486	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00924	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11502169)	"[{""reference_id"": ""UniProtKB:P00924"", ""source_assertion"": ""UniProtKB:P00924 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/46/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00924"", ""source_assertion"": ""UniProtKB:P00924 has the exact SGD cross-reference SGD:S000003486."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/46/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00924"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00924 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_location-a76a36361920_d07ecf5491b0	SGD:S000003588	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00360	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11502169)	"[{""reference_id"": ""UniProtKB:P00360"", ""source_assertion"": ""UniProtKB:P00360 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/26/comments/2/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00360"", ""source_assertion"": ""UniProtKB:P00360 has the exact SGD cross-reference SGD:S000003588."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/26/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00360"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00360 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_location-68361c03bd91_fba6c4615dc2	SGD:S000003769	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00358	Physical protein location from reviewed UniProt. ECO:0000250 (UniProtKB:P00360)	"[{""reference_id"": ""UniProtKB:P00358"", ""source_assertion"": ""UniProtKB:P00358 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/24/comments/2/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00358"", ""source_assertion"": ""UniProtKB:P00358 has the exact SGD cross-reference SGD:S000003769."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/24/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00358"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00358 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_location-a8e2b9a83bfa_561d51b59ecc	SGD:S000003424	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00359	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11502169)	"[{""reference_id"": ""UniProtKB:P00359"", ""source_assertion"": ""UniProtKB:P00359 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/25/comments/2/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00359"", ""source_assertion"": ""UniProtKB:P00359 has the exact SGD cross-reference SGD:S000003424."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/25/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00359"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00359 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_location-f188f7b48d25_64f0ba1605ae	SGD:S000003424	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00359	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961)	"[{""reference_id"": ""UniProtKB:P00359"", ""source_assertion"": ""UniProtKB:P00359 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/25/comments/2/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00359"", ""source_assertion"": ""UniProtKB:P00359 has the exact SGD cross-reference SGD:S000003424."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/25/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00359"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00359 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_location-8718d4e89471_8c7467323da9	SGD:S000001217	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00925	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P00925"", ""source_assertion"": ""UniProtKB:P00925 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/47/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00925"", ""source_assertion"": ""UniProtKB:P00925 has the exact SGD cross-reference SGD:S000001217."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/47/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00925"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00925 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_location-671c5f3e3ce2_91cbb1a4fec0	UniProtKB:P16861	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16861	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03184); ECO:0000269 (PubMed:18313953)	"[{""reference_id"": ""UniProtKB:P16861"", ""source_assertion"": ""UniProtKB:P16861 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/450/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P16861"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16861 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_location-149d6e36e4ea_4a6793fb5987	UniProtKB:P16861	RO:0001025	GO:0005741	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16861	Physical protein location from reviewed UniProt. evidence code not specified by source Topology: Peripheral membrane protein. Orientation: Cytoplasmic side.	"[{""reference_id"": ""UniProtKB:P16861"", ""source_assertion"": ""UniProtKB:P16861 annotates location Mitochondrion outer membrane (SL-0172)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/450/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P16861"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16861 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_location-82095d452da4_21863a74b61f	UniProtKB:P16862	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16862	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03184); ECO:0000269 (PubMed:18313953)	"[{""reference_id"": ""UniProtKB:P16862"", ""source_assertion"": ""UniProtKB:P16862 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/451/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P16862"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16862 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_location-ffa04085ae75_58bb9b2d24a0	UniProtKB:P16862	RO:0001025	GO:0005741	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16862	Physical protein location from reviewed UniProt. evidence code not specified by source Topology: Peripheral membrane protein. Orientation: Cytoplasmic side.	"[{""reference_id"": ""UniProtKB:P16862"", ""source_assertion"": ""UniProtKB:P16862 annotates location Mitochondrion outer membrane (SL-0172)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/451/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P16862"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16862 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_cofactor-444604e711dc_7db1a70115f5	SGD:S000004369	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09201	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00636) Binds 3 Mg(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00636)	"[{""reference_id"": ""UniProtKB:P09201"", ""source_assertion"": ""UniProtKB:P09201 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/222/comments/0/cofactors/0; /results/222/comments/0/note""}, {""reference_id"": ""UniProtKB:P09201"", ""source_assertion"": ""UniProtKB:P09201 has the exact SGD cross-reference SGD:S000004369."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/222/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P09201"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P09201 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_cofactor-4189dbdb3e8f_8c7f78f5b804	SGD:S000000605	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00560	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00558)	"[{""reference_id"": ""UniProtKB:P00560"", ""source_assertion"": ""UniProtKB:P00560 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/35/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P00560"", ""source_assertion"": ""UniProtKB:P00560 has the exact SGD cross-reference SGD:S000000605."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/35/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00560"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00560 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_cofactor-b0cecbe86e3a_f0b02371c879	SGD:S000005874	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P52489	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P52489"", ""source_assertion"": ""UniProtKB:P52489 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2071/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P52489"", ""source_assertion"": ""UniProtKB:P52489 has the exact SGD cross-reference SGD:S000005874."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2071/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P52489"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P52489 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_cofactor-ce6dd34d8bc1_eead1b4d1e83	SGD:S000005874	pathwaymech:has_cofactor	CHEBI:29103	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P52489	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P52489"", ""source_assertion"": ""UniProtKB:P52489 annotates CHEBI:29103 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2071/comments/1/cofactors/0""}, {""reference_id"": ""UniProtKB:P52489"", ""source_assertion"": ""UniProtKB:P52489 has the exact SGD cross-reference SGD:S000005874."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2071/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P52489"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P52489 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_cofactor-38fe84efc750_0d12efa515fd	SGD:S000001543	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P14540	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P14540"", ""source_assertion"": ""UniProtKB:P14540 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/387/comments/0/cofactors/0; /results/387/comments/0/note""}, {""reference_id"": ""UniProtKB:P14540"", ""source_assertion"": ""UniProtKB:P14540 has the exact SGD cross-reference SGD:S000001543."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/387/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P14540"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P14540 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_cofactor-56dca68539a9_6cc440cea0c9	SGD:S000003486	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00924	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:8605183) Mg(2+) is required for catalysis and for stabilizing the dimer. UniProt note evidence: ECO:0000269 (PubMed:8605183)	"[{""reference_id"": ""UniProtKB:P00924"", ""source_assertion"": ""UniProtKB:P00924 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/46/comments/0/cofactors/0; /results/46/comments/0/note""}, {""reference_id"": ""UniProtKB:P00924"", ""source_assertion"": ""UniProtKB:P00924 has the exact SGD cross-reference SGD:S000003486."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/46/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00924"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00924 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_cofactor-47f92cb29771_8d0d71d67c57	SGD:S000000036	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00549	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10413488)	"[{""reference_id"": ""UniProtKB:P00549"", ""source_assertion"": ""UniProtKB:P00549 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/34/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P00549"", ""source_assertion"": ""UniProtKB:P00549 has the exact SGD cross-reference SGD:S000000036."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/34/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00549"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P00549 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_cofactor-fc3224c90256_21b16b1014c8	SGD:S000000036	pathwaymech:has_cofactor	CHEBI:29103	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00549	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000305 (PubMed:9519410)	"[{""reference_id"": ""UniProtKB:P00549"", ""source_assertion"": ""UniProtKB:P00549 annotates CHEBI:29103 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/34/comments/1/cofactors/0""}, {""reference_id"": ""UniProtKB:P00549"", ""source_assertion"": ""UniProtKB:P00549 has the exact SGD cross-reference SGD:S000000036."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/34/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00549"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P00549 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_cofactor-a822dbca7d45_7d58d817a60f	SGD:S000001217	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00925	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified Mg(2+) is required for catalysis and for stabilizing the dimer.	"[{""reference_id"": ""UniProtKB:P00925"", ""source_assertion"": ""UniProtKB:P00925 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/47/comments/0/cofactors/0; /results/47/comments/0/note""}, {""reference_id"": ""UniProtKB:P00925"", ""source_assertion"": ""UniProtKB:P00925 has the exact SGD cross-reference SGD:S000001217."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/47/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00925"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00925 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_cofactor-f8aa76f3edd6_93d7db6d6a5e	UniProtKB:P16861	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16861	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P0A796); ECO:0000255 (HAMAP-Rule:MF_03184)	"[{""reference_id"": ""UniProtKB:P16861"", ""source_assertion"": ""UniProtKB:P16861 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/450/comments/0/cofactors/0""}]"	"[{""id"": ""UniProtKB:P16861"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16861 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_GLYCOLYSIS_cofactor-40bace2a419f_9032886d9518	UniProtKB:P16862	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16862	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03184)	"[{""reference_id"": ""UniProtKB:P16862"", ""source_assertion"": ""UniProtKB:P16862 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/451/comments/0/cofactors/0""}]"	"[{""id"": ""UniProtKB:P16862"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16862 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-001_a4a3f5dc12c4	CHEBI:16526	pathwaymech:consumes	RHEA:10750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea directed reaction 10750 places CHEBI:16526 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10750 rh:substrates http://rdf.rhea-db.org/10748_R; http://rdf.rhea-db.org/10748_R rh:contains1 http://rdf.rhea-db.org/Participant_10748_compound_4391; http://rdf.rhea-db.org/Participant_10748_compound_4391 rh:compound http://rdf.rhea-db.org/Compound_4391; rh:accession""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""CO2 + H2O => hydrogencarbonate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-002_23bac1f03aeb	CHEBI:15377	pathwaymech:consumes	RHEA:10750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea directed reaction 10750 places CHEBI:15377 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10750 rh:substrates http://rdf.rhea-db.org/10748_R; http://rdf.rhea-db.org/10748_R rh:contains1 http://rdf.rhea-db.org/Participant_10748_compound_1283; http://rdf.rhea-db.org/Participant_10748_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; rh:accession""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""CO2 + H2O => hydrogencarbonate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-003_ffb1a9340f6a	RHEA:10750	pathwaymech:produces	CHEBI:17544	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea directed reaction 10750 places CHEBI:17544 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10750 rh:products http://rdf.rhea-db.org/10748_L; http://rdf.rhea-db.org/10748_L rh:contains1 http://rdf.rhea-db.org/Participant_10748_compound_1123; http://rdf.rhea-db.org/Participant_10748_compound_1123 rh:compound http://rdf.rhea-db.org/Compound_1123; rh:accession""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""CO2 + H2O => hydrogencarbonate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-004_109b18a100de	RHEA:10750	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea directed reaction 10750 places CHEBI:15378 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10750 rh:products http://rdf.rhea-db.org/10748_L; http://rdf.rhea-db.org/10748_L rh:contains1 http://rdf.rhea-db.org/Participant_10748_compound_3249; http://rdf.rhea-db.org/Participant_10748_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""CO2 + H2O => hydrogencarbonate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-005_8589bc27c642	RHEA-COMP:10505	pathwaymech:consumes	RHEA:13502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13502	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea directed reaction 13502 places RHEA-COMP:10505 on its substrates side with coefficient 1. This is a whole generic protein-bearing carrier state, not an isolated lysine residue."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:substrates http://rdf.rhea-db.org/13501_L; http://rdf.rhea-db.org/13501_L rh:contains1 http://rdf.rhea-db.org/Participant_13501_compound_10505; http://rdf.rhea-db.org/Participant_13501_compound_10505 rh:compound http://rdf.rhea-db.org/Compound_10505; rh:accession""}]"	"[{""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-006_5417b652f4d5	CHEBI:17544	pathwaymech:consumes	RHEA:13502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13502	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea directed reaction 13502 places CHEBI:17544 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:substrates http://rdf.rhea-db.org/13501_L; http://rdf.rhea-db.org/13501_L rh:contains1 http://rdf.rhea-db.org/Participant_13501_compound_1123; http://rdf.rhea-db.org/Participant_13501_compound_1123 rh:compound http://rdf.rhea-db.org/Compound_1123; rh:accession""}]"	"[{""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-007_f0fe3621bc6c	CHEBI:30616	pathwaymech:consumes	RHEA:13502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13502	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea directed reaction 13502 places CHEBI:30616 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:substrates http://rdf.rhea-db.org/13501_L; http://rdf.rhea-db.org/13501_L rh:contains1 http://rdf.rhea-db.org/Participant_13501_compound_6372; http://rdf.rhea-db.org/Participant_13501_compound_6372 rh:compound http://rdf.rhea-db.org/Compound_6372; rh:accession""}]"	"[{""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-008_de27bc9c90d6	RHEA:13502	pathwaymech:produces	RHEA-COMP:10506	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13502	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea directed reaction 13502 places RHEA-COMP:10506 on its products side with coefficient 1. This is a whole generic protein-bearing carrier state, not an isolated lysine residue."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:products http://rdf.rhea-db.org/13501_R; http://rdf.rhea-db.org/13501_R rh:contains1 http://rdf.rhea-db.org/Participant_13501_compound_10506; http://rdf.rhea-db.org/Participant_13501_compound_10506 rh:compound http://rdf.rhea-db.org/Compound_10506; rh:accession""}]"	"[{""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-009_0ed8153dbd1e	RHEA:13502	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13502	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea directed reaction 13502 places CHEBI:456216 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:products http://rdf.rhea-db.org/13501_R; http://rdf.rhea-db.org/13501_R rh:contains1 http://rdf.rhea-db.org/Participant_13501_compound_2710; http://rdf.rhea-db.org/Participant_13501_compound_2710 rh:compound http://rdf.rhea-db.org/Compound_2710; rh:accession""}]"	"[{""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-010_bd4aad37d77a	RHEA:13502	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13502	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea directed reaction 13502 places CHEBI:43474 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:products http://rdf.rhea-db.org/13501_R; http://rdf.rhea-db.org/13501_R rh:contains1 http://rdf.rhea-db.org/Participant_13501_compound_5518; http://rdf.rhea-db.org/Participant_13501_compound_5518 rh:compound http://rdf.rhea-db.org/Compound_5518; rh:accession""}]"	"[{""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-011_ed3e6570ab79	RHEA:13502	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13502	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea directed reaction 13502 places CHEBI:15378 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:products http://rdf.rhea-db.org/13501_R; http://rdf.rhea-db.org/13501_R rh:contains1 http://rdf.rhea-db.org/Participant_13501_compound_3249; http://rdf.rhea-db.org/Participant_13501_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-012_103468e631e4	CHEBI:58668	pathwaymech:consumes	RHEA:22613	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-627|RHEA:22613	Stoichiometric coefficient 1. Native CPD-627 leaves CoA stereocenters unspecified; the current physiological CoA structure is a narrower representation, not an exact native-structure equivalence.	"[{""reference_id"": ""RHEA:22613"", ""source_assertion"": ""Rhea directed reaction 22613 places CHEBI:58668 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22613 rh:substrates http://rdf.rhea-db.org/22612_L; http://rdf.rhea-db.org/22612_L rh:contains1 http://rdf.rhea-db.org/Participant_22612_compound_2663; http://rdf.rhea-db.org/Participant_22612_compound_2663 rh:compound http://rdf.rhea-db.org/Compound_2663; rh:accession""}, {""reference_id"": ""MetaCyc:CPD-627"", ""source_assertion"": ""The native S-citramalyl-CoA InChI explicitly leaves five CoA stereocenters unspecified. Current physiological CoA stereochemistry narrows that representation."", ""source_locator"": ""Compound[@frameid=\""CPD-627\""]/inchi""}]"	"[{""id"": ""MetaCyc:CPD-627"", ""source_sha256"": ""78b0cec26e67e76cffbbb982c02e2cd2d75a8b5bd3281efa585d31af10cafe01"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""(3S)-citramalyl-CoA"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-627""}, {""id"": ""RHEA:22613"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""(3S)-citramalyl-CoA => pyruvate + acetyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-013_b49d6c97f92e	RHEA:22613	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22613	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:22613"", ""source_assertion"": ""Rhea directed reaction 22613 places CHEBI:15361 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22613 rh:products http://rdf.rhea-db.org/22612_R; http://rdf.rhea-db.org/22612_R rh:contains1 http://rdf.rhea-db.org/Participant_22612_compound_3719; http://rdf.rhea-db.org/Participant_22612_compound_3719 rh:compound http://rdf.rhea-db.org/Compound_3719; rh:accession""}]"	"[{""id"": ""RHEA:22613"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""(3S)-citramalyl-CoA => pyruvate + acetyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-014_633fc861ce14	RHEA:22613	pathwaymech:produces	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22613	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:22613"", ""source_assertion"": ""Rhea directed reaction 22613 places CHEBI:57288 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22613 rh:products http://rdf.rhea-db.org/22612_R; http://rdf.rhea-db.org/22612_R rh:contains1 http://rdf.rhea-db.org/Participant_22612_compound_4271; http://rdf.rhea-db.org/Participant_22612_compound_4271 rh:compound http://rdf.rhea-db.org/Compound_4271; rh:accession""}]"	"[{""id"": ""RHEA:22613"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""(3S)-citramalyl-CoA => pyruvate + acetyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-015_66b34c2bad32	CHEBI:33190	pathwaymech:consumes	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea directed reaction 26440 places CHEBI:33190 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:substrates http://rdf.rhea-db.org/26438_R; http://rdf.rhea-db.org/26438_R rh:contains1 http://rdf.rhea-db.org/Participant_26438_compound_5274; http://rdf.rhea-db.org/Participant_26438_compound_5274 rh:compound http://rdf.rhea-db.org/Compound_5274; rh:accession""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-016_b35593ba2c9c	CHEBI:57783	pathwaymech:consumes	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea directed reaction 26440 places CHEBI:57783 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:substrates http://rdf.rhea-db.org/26438_R; http://rdf.rhea-db.org/26438_R rh:contains1 http://rdf.rhea-db.org/Participant_26438_compound_3438; http://rdf.rhea-db.org/Participant_26438_compound_3438 rh:compound http://rdf.rhea-db.org/Compound_3438; rh:accession""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-017_3cfe3f842136	CHEBI:15378	pathwaymech:consumes	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea directed reaction 26440 places CHEBI:15378 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:substrates http://rdf.rhea-db.org/26438_R; http://rdf.rhea-db.org/26438_R rh:contains1 http://rdf.rhea-db.org/Participant_26438_compound_3249; http://rdf.rhea-db.org/Participant_26438_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-018_254ee873e730	RHEA:26440	pathwaymech:produces	CHEBI:16510	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea directed reaction 26440 places CHEBI:16510 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:products http://rdf.rhea-db.org/26438_L; http://rdf.rhea-db.org/26438_L rh:contains1 http://rdf.rhea-db.org/Participant_26438_compound_3378; http://rdf.rhea-db.org/Participant_26438_compound_3378 rh:compound http://rdf.rhea-db.org/Compound_3378; rh:accession""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-019_c40c199459ec	RHEA:26440	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea directed reaction 26440 places CHEBI:58349 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:products http://rdf.rhea-db.org/26438_L; http://rdf.rhea-db.org/26438_L rh:contains1 http://rdf.rhea-db.org/Participant_26438_compound_5188; http://rdf.rhea-db.org/Participant_26438_compound_5188 rh:compound http://rdf.rhea-db.org/Compound_5188; rh:accession""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-020_45697515928a	CHEBI:57384	pathwaymech:consumes	RHEA:26448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea directed reaction 26448 places CHEBI:57384 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448 rh:substrates http://rdf.rhea-db.org/26446_R; http://rdf.rhea-db.org/26446_R rh:contains1 http://rdf.rhea-db.org/Participant_26446_compound_5125; http://rdf.rhea-db.org/Participant_26446_compound_5125 rh:compound http://rdf.rhea-db.org/Compound_5125; rh:accession""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""malonyl-CoA + NADPH + H(+) => 3-oxopropanoate + NADP(+) + CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-021_0b849621d27d	CHEBI:57783	pathwaymech:consumes	RHEA:26448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea directed reaction 26448 places CHEBI:57783 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448 rh:substrates http://rdf.rhea-db.org/26446_R; http://rdf.rhea-db.org/26446_R rh:contains1 http://rdf.rhea-db.org/Participant_26446_compound_3438; http://rdf.rhea-db.org/Participant_26446_compound_3438 rh:compound http://rdf.rhea-db.org/Compound_3438; rh:accession""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""malonyl-CoA + NADPH + H(+) => 3-oxopropanoate + NADP(+) + CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-022_97f98d14821d	CHEBI:15378	pathwaymech:consumes	RHEA:26448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea directed reaction 26448 places CHEBI:15378 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448 rh:substrates http://rdf.rhea-db.org/26446_R; http://rdf.rhea-db.org/26446_R rh:contains1 http://rdf.rhea-db.org/Participant_26446_compound_3249; http://rdf.rhea-db.org/Participant_26446_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""malonyl-CoA + NADPH + H(+) => 3-oxopropanoate + NADP(+) + CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-023_79fc4c8b8217	RHEA:26448	pathwaymech:produces	CHEBI:33190	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea directed reaction 26448 places CHEBI:33190 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448 rh:products http://rdf.rhea-db.org/26446_L; http://rdf.rhea-db.org/26446_L rh:contains1 http://rdf.rhea-db.org/Participant_26446_compound_5274; http://rdf.rhea-db.org/Participant_26446_compound_5274 rh:compound http://rdf.rhea-db.org/Compound_5274; rh:accession""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""malonyl-CoA + NADPH + H(+) => 3-oxopropanoate + NADP(+) + CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-024_12cf7c9371af	RHEA:26448	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea directed reaction 26448 places CHEBI:58349 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448 rh:products http://rdf.rhea-db.org/26446_L; http://rdf.rhea-db.org/26446_L rh:contains1 http://rdf.rhea-db.org/Participant_26446_compound_5188; http://rdf.rhea-db.org/Participant_26446_compound_5188 rh:compound http://rdf.rhea-db.org/Compound_5188; rh:accession""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""malonyl-CoA + NADPH + H(+) => 3-oxopropanoate + NADP(+) + CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-025_91220813bedc	RHEA:26448	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea directed reaction 26448 places CHEBI:57287 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448 rh:products http://rdf.rhea-db.org/26446_L; http://rdf.rhea-db.org/26446_L rh:contains1 http://rdf.rhea-db.org/Participant_26446_compound_1264; http://rdf.rhea-db.org/Participant_26446_compound_1264 rh:compound http://rdf.rhea-db.org/Compound_1264; rh:accession""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""malonyl-CoA + NADPH + H(+) => 3-oxopropanoate + NADP(+) + CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-026_e8e598517741	CHEBI:57367	pathwaymech:consumes	RHEA:26456	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea directed reaction 26456 places CHEBI:57367 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456 rh:substrates http://rdf.rhea-db.org/26454_R; http://rdf.rhea-db.org/26454_R rh:contains1 http://rdf.rhea-db.org/Participant_26454_compound_2006; http://rdf.rhea-db.org/Participant_26454_compound_2006 rh:compound http://rdf.rhea-db.org/Compound_2006; rh:accession""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""acryloyl-CoA + NADPH + H(+) => propanoyl-CoA + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-027_c69850eac0fd	CHEBI:57783	pathwaymech:consumes	RHEA:26456	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea directed reaction 26456 places CHEBI:57783 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456 rh:substrates http://rdf.rhea-db.org/26454_R; http://rdf.rhea-db.org/26454_R rh:contains1 http://rdf.rhea-db.org/Participant_26454_compound_3438; http://rdf.rhea-db.org/Participant_26454_compound_3438 rh:compound http://rdf.rhea-db.org/Compound_3438; rh:accession""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""acryloyl-CoA + NADPH + H(+) => propanoyl-CoA + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-028_808d5e9a1040	CHEBI:15378	pathwaymech:consumes	RHEA:26456	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea directed reaction 26456 places CHEBI:15378 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456 rh:substrates http://rdf.rhea-db.org/26454_R; http://rdf.rhea-db.org/26454_R rh:contains1 http://rdf.rhea-db.org/Participant_26454_compound_3249; http://rdf.rhea-db.org/Participant_26454_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""acryloyl-CoA + NADPH + H(+) => propanoyl-CoA + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-029_51c66ce1ecf0	RHEA:26456	pathwaymech:produces	CHEBI:57392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea directed reaction 26456 places CHEBI:57392 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456 rh:products http://rdf.rhea-db.org/26454_L; http://rdf.rhea-db.org/26454_L rh:contains1 http://rdf.rhea-db.org/Participant_26454_compound_3421; http://rdf.rhea-db.org/Participant_26454_compound_3421 rh:compound http://rdf.rhea-db.org/Compound_3421; rh:accession""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""acryloyl-CoA + NADPH + H(+) => propanoyl-CoA + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-030_6aec8a820564	RHEA:26456	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea directed reaction 26456 places CHEBI:58349 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456 rh:products http://rdf.rhea-db.org/26454_L; http://rdf.rhea-db.org/26454_L rh:contains1 http://rdf.rhea-db.org/Participant_26454_compound_5188; http://rdf.rhea-db.org/Participant_26454_compound_5188 rh:compound http://rdf.rhea-db.org/Compound_5188; rh:accession""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""acryloyl-CoA + NADPH + H(+) => propanoyl-CoA + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-031_ad9ceaa27306	CHEBI:58528	pathwaymech:consumes	RHEA:26519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26519	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26519"", ""source_assertion"": ""Rhea directed reaction 26519 places CHEBI:58528 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26519 rh:substrates http://rdf.rhea-db.org/26518_L; http://rdf.rhea-db.org/26518_L rh:contains1 http://rdf.rhea-db.org/Participant_26518_compound_6030; http://rdf.rhea-db.org/Participant_26518_compound_6030 rh:compound http://rdf.rhea-db.org/Compound_6030; rh:accession""}]"	"[{""id"": ""RHEA:26519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-hydroxypropanoyl-CoA => acryloyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-032_f1115ddc6acd	RHEA:26519	pathwaymech:produces	CHEBI:57367	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26519	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26519"", ""source_assertion"": ""Rhea directed reaction 26519 places CHEBI:57367 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26519 rh:products http://rdf.rhea-db.org/26518_R; http://rdf.rhea-db.org/26518_R rh:contains1 http://rdf.rhea-db.org/Participant_26518_compound_2006; http://rdf.rhea-db.org/Participant_26518_compound_2006 rh:compound http://rdf.rhea-db.org/Compound_2006; rh:accession""}]"	"[{""id"": ""RHEA:26519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-hydroxypropanoyl-CoA => acryloyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-033_bb51a9deeb9f	RHEA:26519	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26519	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26519"", ""source_assertion"": ""Rhea directed reaction 26519 places CHEBI:15377 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26519 rh:products http://rdf.rhea-db.org/26518_R; http://rdf.rhea-db.org/26518_R rh:contains1 http://rdf.rhea-db.org/Participant_26518_compound_1283; http://rdf.rhea-db.org/Participant_26518_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; rh:accession""}]"	"[{""id"": ""RHEA:26519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-hydroxypropanoyl-CoA => acryloyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-034_aef4a435269f	CHEBI:16510	pathwaymech:consumes	RHEA:26535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26535	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea directed reaction 26535 places CHEBI:16510 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535 rh:substrates http://rdf.rhea-db.org/26534_L; http://rdf.rhea-db.org/26534_L rh:contains1 http://rdf.rhea-db.org/Participant_26534_compound_3378; http://rdf.rhea-db.org/Participant_26534_compound_3378 rh:compound http://rdf.rhea-db.org/Compound_3378; rh:accession""}]"	"[{""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-035_c16b5e889a36	CHEBI:30616	pathwaymech:consumes	RHEA:26535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26535	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea directed reaction 26535 places CHEBI:30616 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535 rh:substrates http://rdf.rhea-db.org/26534_L; http://rdf.rhea-db.org/26534_L rh:contains1 http://rdf.rhea-db.org/Participant_26534_compound_6372; http://rdf.rhea-db.org/Participant_26534_compound_6372 rh:compound http://rdf.rhea-db.org/Compound_6372; rh:accession""}]"	"[{""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-036_f91d2df6b7d7	CHEBI:57287	pathwaymech:consumes	RHEA:26535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26535	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea directed reaction 26535 places CHEBI:57287 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535 rh:substrates http://rdf.rhea-db.org/26534_L; http://rdf.rhea-db.org/26534_L rh:contains1 http://rdf.rhea-db.org/Participant_26534_compound_1264; http://rdf.rhea-db.org/Participant_26534_compound_1264 rh:compound http://rdf.rhea-db.org/Compound_1264; rh:accession""}]"	"[{""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-037_641f8ddfc0ca	RHEA:26535	pathwaymech:produces	CHEBI:58528	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26535	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea directed reaction 26535 places CHEBI:58528 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535 rh:products http://rdf.rhea-db.org/26534_R; http://rdf.rhea-db.org/26534_R rh:contains1 http://rdf.rhea-db.org/Participant_26534_compound_6030; http://rdf.rhea-db.org/Participant_26534_compound_6030 rh:compound http://rdf.rhea-db.org/Compound_6030; rh:accession""}]"	"[{""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-038_c450cea6db09	RHEA:26535	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26535	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea directed reaction 26535 places CHEBI:456215 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535 rh:products http://rdf.rhea-db.org/26534_R; http://rdf.rhea-db.org/26534_R rh:contains1 http://rdf.rhea-db.org/Participant_26534_compound_2590; http://rdf.rhea-db.org/Participant_26534_compound_2590 rh:compound http://rdf.rhea-db.org/Compound_2590; rh:accession""}]"	"[{""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-039_6757e6a64410	RHEA:26535	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26535	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea directed reaction 26535 places CHEBI:33019 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535 rh:products http://rdf.rhea-db.org/26534_R; http://rdf.rhea-db.org/26534_R rh:contains1 http://rdf.rhea-db.org/Participant_26534_compound_2106; http://rdf.rhea-db.org/Participant_26534_compound_2106 rh:compound http://rdf.rhea-db.org/Compound_2106; rh:accession""}]"	"[{""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-040_a2c3d7fe4116	CHEBI:57392	pathwaymech:consumes	RHEA:38261	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38261	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38261"", ""source_assertion"": ""Rhea directed reaction 38261 places CHEBI:57392 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38261 rh:substrates http://rdf.rhea-db.org/38259_R; http://rdf.rhea-db.org/38259_R rh:contains1 http://rdf.rhea-db.org/Participant_38259_compound_3421; http://rdf.rhea-db.org/Participant_38259_compound_3421 rh:compound http://rdf.rhea-db.org/Compound_3421; rh:accession""}]"	"[{""id"": ""RHEA:38261"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""propanoyl-CoA + glyoxylate => (2R,3S)-beta-methylmalyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-041_0cf59b24adfa	CHEBI:36655	pathwaymech:consumes	RHEA:38261	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38261	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38261"", ""source_assertion"": ""Rhea directed reaction 38261 places CHEBI:36655 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38261 rh:substrates http://rdf.rhea-db.org/38259_R; http://rdf.rhea-db.org/38259_R rh:contains1 http://rdf.rhea-db.org/Participant_38259_compound_3124; http://rdf.rhea-db.org/Participant_38259_compound_3124 rh:compound http://rdf.rhea-db.org/Compound_3124; rh:accession""}]"	"[{""id"": ""RHEA:38261"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""propanoyl-CoA + glyoxylate => (2R,3S)-beta-methylmalyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-042_1f881c39ab3a	RHEA:38261	pathwaymech:produces	CHEBI:75634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-9409|PMID:19955419|RHEA:38261	Stoichiometric coefficient 1. The current acyl stereochemistry agrees with primary Figure 1; native CPD-9409 has the opposite encoded acyl configuration despite its matching label. No exact structure mapping is asserted.	"[{""reference_id"": ""RHEA:38261"", ""source_assertion"": ""Rhea directed reaction 38261 places CHEBI:75634 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38261 rh:products http://rdf.rhea-db.org/38259_L; http://rdf.rhea-db.org/38259_L rh:contains1 http://rdf.rhea-db.org/Participant_38259_compound_8545; http://rdf.rhea-db.org/Participant_38259_compound_8545 rh:compound http://rdf.rhea-db.org/Compound_8545; rh:accession""}, {""reference_id"": ""MetaCyc:CPD-9409"", ""source_assertion"": ""The native compound label is (2R,3S)-beta-methylmalyl-CoA, but its stored InChI encodes the opposite acyl stereocenters from current ChEBI75634. This structured-source conflict is explicitly rejected as an exact mapping."", ""source_locator"": ""Compound[@frameid=\""CPD-9409\""]/common-name; inchi""}, {""reference_id"": ""PMID:19955419"", ""source_assertion"": ""Figure 1 explicitly labels the second-cycle condensation product (2R,3S)-beta-methylmalyl-CoA; this is the selected current Rhea structure."", ""source_locator"": ""Figure 1, second cycle intermediate between activities 10b and 11""}]"	"[{""id"": ""MetaCyc:CPD-9409"", ""source_sha256"": ""f22b89cb940863628ff110286d3c0ecaada493f7090fc209d8aba82360107b17"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""(2R,3S)-β-methylmalyl-CoA"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-9409""}, {""id"": ""PMID:19955419"", ""source_sha256"": ""ef7bbdc7b8ebc8cd62ae4d586fe953a767fdce2865900f742e43336381fde7b1"", ""source_version"": ""Complete original primary full-text body retrieved 2026-10-11; strain and construct limits retained"", ""title"": ""Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2795484/""}, {""id"": ""RHEA:38261"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""propanoyl-CoA + glyoxylate => (2R,3S)-beta-methylmalyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-043_3d8e98cba76f	CHEBI:75634	pathwaymech:consumes	RHEA:38264	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-9409|PMID:19955419|RHEA:38264	Stoichiometric coefficient 1. The current acyl stereochemistry agrees with primary Figure 1; native CPD-9409 has the opposite encoded acyl configuration despite its matching label. No exact structure mapping is asserted.	"[{""reference_id"": ""RHEA:38264"", ""source_assertion"": ""Rhea directed reaction 38264 places CHEBI:75634 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38264 rh:substrates http://rdf.rhea-db.org/38263_L; http://rdf.rhea-db.org/38263_L rh:contains1 http://rdf.rhea-db.org/Participant_38263_compound_8545; http://rdf.rhea-db.org/Participant_38263_compound_8545 rh:compound http://rdf.rhea-db.org/Compound_8545; rh:accession""}, {""reference_id"": ""MetaCyc:CPD-9409"", ""source_assertion"": ""The native compound label is (2R,3S)-beta-methylmalyl-CoA, but its stored InChI encodes the opposite acyl stereocenters from current ChEBI75634. This structured-source conflict is explicitly rejected as an exact mapping."", ""source_locator"": ""Compound[@frameid=\""CPD-9409\""]/common-name; inchi""}, {""reference_id"": ""PMID:19955419"", ""source_assertion"": ""Figure 1 explicitly labels the second-cycle condensation product (2R,3S)-beta-methylmalyl-CoA; this is the selected current Rhea structure."", ""source_locator"": ""Figure 1, second cycle intermediate between activities 10b and 11""}]"	"[{""id"": ""MetaCyc:CPD-9409"", ""source_sha256"": ""f22b89cb940863628ff110286d3c0ecaada493f7090fc209d8aba82360107b17"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""(2R,3S)-β-methylmalyl-CoA"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-9409""}, {""id"": ""PMID:19955419"", ""source_sha256"": ""ef7bbdc7b8ebc8cd62ae4d586fe953a767fdce2865900f742e43336381fde7b1"", ""source_version"": ""Complete original primary full-text body retrieved 2026-10-11; strain and construct limits retained"", ""title"": ""Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2795484/""}, {""id"": ""RHEA:38264"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""(2R,3S)-beta-methylmalyl-CoA => 2-methylfumaryl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-044_a8b76bc1ac99	RHEA:38264	pathwaymech:produces	CHEBI:75635	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38264	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38264"", ""source_assertion"": ""Rhea directed reaction 38264 places CHEBI:75635 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38264 rh:products http://rdf.rhea-db.org/38263_R; http://rdf.rhea-db.org/38263_R rh:contains1 http://rdf.rhea-db.org/Participant_38263_compound_8546; http://rdf.rhea-db.org/Participant_38263_compound_8546 rh:compound http://rdf.rhea-db.org/Compound_8546; rh:accession""}]"	"[{""id"": ""RHEA:38264"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""(2R,3S)-beta-methylmalyl-CoA => 2-methylfumaryl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-045_ac6e9a99a387	RHEA:38264	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38264	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38264"", ""source_assertion"": ""Rhea directed reaction 38264 places CHEBI:15377 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38264 rh:products http://rdf.rhea-db.org/38263_R; http://rdf.rhea-db.org/38263_R rh:contains1 http://rdf.rhea-db.org/Participant_38263_compound_1283; http://rdf.rhea-db.org/Participant_38263_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; rh:accession""}]"	"[{""id"": ""RHEA:38264"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""(2R,3S)-beta-methylmalyl-CoA => 2-methylfumaryl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-046_d0dc86248c05	CHEBI:75635	pathwaymech:consumes	RHEA:38268	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38268	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38268"", ""source_assertion"": ""Rhea directed reaction 38268 places CHEBI:75635 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38268 rh:substrates http://rdf.rhea-db.org/38267_L; http://rdf.rhea-db.org/38267_L rh:contains1 http://rdf.rhea-db.org/Participant_38267_compound_8546; http://rdf.rhea-db.org/Participant_38267_compound_8546 rh:compound http://rdf.rhea-db.org/Compound_8546; rh:accession""}]"	"[{""id"": ""RHEA:38268"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""2-methylfumaryl-CoA => 3-methylfumaryl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-047_cd621c3281b5	RHEA:38268	pathwaymech:produces	CHEBI:75636	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38268	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38268"", ""source_assertion"": ""Rhea directed reaction 38268 places CHEBI:75636 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38268 rh:products http://rdf.rhea-db.org/38267_R; http://rdf.rhea-db.org/38267_R rh:contains1 http://rdf.rhea-db.org/Participant_38267_compound_8547; http://rdf.rhea-db.org/Participant_38267_compound_8547 rh:compound http://rdf.rhea-db.org/Compound_8547; rh:accession""}]"	"[{""id"": ""RHEA:38268"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""2-methylfumaryl-CoA => 3-methylfumaryl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-048_7c2f1106f111	CHEBI:75636	pathwaymech:consumes	RHEA:38273	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38273	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38273"", ""source_assertion"": ""Rhea directed reaction 38273 places CHEBI:75636 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38273 rh:substrates http://rdf.rhea-db.org/38271_R; http://rdf.rhea-db.org/38271_R rh:contains1 http://rdf.rhea-db.org/Participant_38271_compound_8547; http://rdf.rhea-db.org/Participant_38271_compound_8547 rh:compound http://rdf.rhea-db.org/Compound_8547; rh:accession""}]"	"[{""id"": ""RHEA:38273"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-methylfumaryl-CoA + H2O => (3S)-citramalyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-049_dfb3ae4bb9d2	CHEBI:15377	pathwaymech:consumes	RHEA:38273	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38273	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:38273"", ""source_assertion"": ""Rhea directed reaction 38273 places CHEBI:15377 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38273 rh:substrates http://rdf.rhea-db.org/38271_R; http://rdf.rhea-db.org/38271_R rh:contains1 http://rdf.rhea-db.org/Participant_38271_compound_1283; http://rdf.rhea-db.org/Participant_38271_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; rh:accession""}]"	"[{""id"": ""RHEA:38273"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-methylfumaryl-CoA + H2O => (3S)-citramalyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-050_cbd33205bc32	RHEA:38273	pathwaymech:produces	CHEBI:58668	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-627|RHEA:38273	Stoichiometric coefficient 1. Native CPD-627 leaves CoA stereocenters unspecified; the current physiological CoA structure is a narrower representation, not an exact native-structure equivalence.	"[{""reference_id"": ""RHEA:38273"", ""source_assertion"": ""Rhea directed reaction 38273 places CHEBI:58668 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38273 rh:products http://rdf.rhea-db.org/38271_L; http://rdf.rhea-db.org/38271_L rh:contains1 http://rdf.rhea-db.org/Participant_38271_compound_2663; http://rdf.rhea-db.org/Participant_38271_compound_2663 rh:compound http://rdf.rhea-db.org/Compound_2663; rh:accession""}, {""reference_id"": ""MetaCyc:CPD-627"", ""source_assertion"": ""The native S-citramalyl-CoA InChI explicitly leaves five CoA stereocenters unspecified. Current physiological CoA stereochemistry narrows that representation."", ""source_locator"": ""Compound[@frameid=\""CPD-627\""]/inchi""}]"	"[{""id"": ""MetaCyc:CPD-627"", ""source_sha256"": ""78b0cec26e67e76cffbbb982c02e2cd2d75a8b5bd3281efa585d31af10cafe01"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""(3S)-citramalyl-CoA"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-627""}, {""id"": ""RHEA:38273"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-methylfumaryl-CoA + H2O => (3S)-citramalyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-051_9af7e90cf11a	RHEA-COMP:10506	pathwaymech:consumes	RHEA:54729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:54729	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:54729"", ""source_assertion"": ""Rhea directed reaction 54729 places RHEA-COMP:10506 on its substrates side with coefficient 1. This is a whole generic protein-bearing carrier state, not an isolated lysine residue."", ""source_locator"": ""http://rdf.rhea-db.org/54729 rh:substrates http://rdf.rhea-db.org/54728_L; http://rdf.rhea-db.org/54728_L rh:contains1 http://rdf.rhea-db.org/Participant_54728_compound_10506; http://rdf.rhea-db.org/Participant_54728_compound_10506 rh:compound http://rdf.rhea-db.org/Compound_10506; rh:accession""}]"	"[{""id"": ""RHEA:54729"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA => N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-052_c71e61f19c7f	CHEBI:57288	pathwaymech:consumes	RHEA:54729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:54729	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:54729"", ""source_assertion"": ""Rhea directed reaction 54729 places CHEBI:57288 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/54729 rh:substrates http://rdf.rhea-db.org/54728_L; http://rdf.rhea-db.org/54728_L rh:contains1 http://rdf.rhea-db.org/Participant_54728_compound_4271; http://rdf.rhea-db.org/Participant_54728_compound_4271 rh:compound http://rdf.rhea-db.org/Compound_4271; rh:accession""}]"	"[{""id"": ""RHEA:54729"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA => N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-053_974d901f1878	RHEA:54729	pathwaymech:produces	RHEA-COMP:10505	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:54729	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:54729"", ""source_assertion"": ""Rhea directed reaction 54729 places RHEA-COMP:10505 on its products side with coefficient 1. This is a whole generic protein-bearing carrier state, not an isolated lysine residue."", ""source_locator"": ""http://rdf.rhea-db.org/54729 rh:products http://rdf.rhea-db.org/54728_R; http://rdf.rhea-db.org/54728_R rh:contains1 http://rdf.rhea-db.org/Participant_54728_compound_10505; http://rdf.rhea-db.org/Participant_54728_compound_10505 rh:compound http://rdf.rhea-db.org/Compound_10505; rh:accession""}]"	"[{""id"": ""RHEA:54729"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA => N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-054_60ea90ad52bf	RHEA:54729	pathwaymech:produces	CHEBI:57384	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:54729	Stoichiometric coefficient 1.	"[{""reference_id"": ""RHEA:54729"", ""source_assertion"": ""Rhea directed reaction 54729 places CHEBI:57384 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/54729 rh:products http://rdf.rhea-db.org/54728_R; http://rdf.rhea-db.org/54728_R rh:contains1 http://rdf.rhea-db.org/Participant_54728_compound_5125; http://rdf.rhea-db.org/Participant_54728_compound_5125 rh:compound http://rdf.rhea-db.org/Compound_5125; rh:accession""}]"	"[{""id"": ""RHEA:54729"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA => N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-055_122fbbf3ed41	MetaCyc:PWY-5744	BFO:0000051	RHEA:10750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5744|MetaCyc:RXN0-5224|RHEA:10750	Native CO2/bicarbonate equilibration remains nonenzymatic here; no unidentified carbonic anhydrase is assigned.	"[{""reference_id"": ""MetaCyc:PWY-5744"", ""source_assertion"": ""PWY-5744 explicitly lists RXN0-5224 among its 13 native reaction objects."", ""source_locator"": ""Pathway[@frameid='PWY-5744']/reaction-list/Reaction[@frameid='RXN0-5224']""}, {""reference_id"": ""MetaCyc:RXN0-5224"", ""source_assertion"": ""The native reaction links Rhea 10751; current family/direction and chemical structure are verified separately."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea master 10748 explicitly links directed member 10750; the selected sides follow the glyoxylate-assimilation cycle."", ""source_locator"": ""http://rdf.rhea-db.org/10748 rh:directionalReaction http://rdf.rhea-db.org/10750; http://rdf.rhea-db.org/10750 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5744"", ""source_sha256"": ""ae581b84fcd4a23a9968124b963f740179d11717099ab6007cd9ba3afa87f9a2"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""glyoxylate assimilation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5744""}, {""id"": ""MetaCyc:RXN0-5224"", ""source_sha256"": ""0f8ea48758c659d86a3f3fb429d73ee60560ab80646e4233481caa7e4cf3ffb5"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""RXN0-5224"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5224""}, {""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""CO2 + H2O => hydrogencarbonate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-056_363ea2ee81c8	MetaCyc:PWY-5744	BFO:0000051	RHEA:13502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-CARBOXYL-RXN|MetaCyc:PWY-5744|RHEA:13502	All native pathway members are retained; normalized current chemical forms are not blanket exact mappings of native structures.	"[{""reference_id"": ""MetaCyc:PWY-5744"", ""source_assertion"": ""PWY-5744 explicitly lists BIOTIN-CARBOXYL-RXN among its 13 native reaction objects."", ""source_locator"": ""Pathway[@frameid='PWY-5744']/reaction-list/Reaction[@frameid='BIOTIN-CARBOXYL-RXN']""}, {""reference_id"": ""MetaCyc:BIOTIN-CARBOXYL-RXN"", ""source_assertion"": ""The native reaction links Rhea 13502; current family/direction and chemical structure are verified separately."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea master 13501 explicitly links directed member 13502; the selected sides follow the glyoxylate-assimilation cycle."", ""source_locator"": ""http://rdf.rhea-db.org/13501 rh:directionalReaction http://rdf.rhea-db.org/13502; http://rdf.rhea-db.org/13502 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:BIOTIN-CARBOXYL-RXN"", ""source_sha256"": ""85d21badd44d87a38c810e80b4ee276f91cf66fbe2d1995103ffdbb77ec3728b"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""BIOTIN-CARBOXYL-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-CARBOXYL-RXN""}, {""id"": ""MetaCyc:PWY-5744"", ""source_sha256"": ""ae581b84fcd4a23a9968124b963f740179d11717099ab6007cd9ba3afa87f9a2"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""glyoxylate assimilation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5744""}, {""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-057_6cd5cba0b246	MetaCyc:PWY-5744	BFO:0000051	RHEA:54729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5744|MetaCyc:RXN0-5055|RHEA:54729	All native pathway members are retained; normalized current chemical forms are not blanket exact mappings of native structures.	"[{""reference_id"": ""MetaCyc:PWY-5744"", ""source_assertion"": ""PWY-5744 explicitly lists RXN0-5055 among its 13 native reaction objects."", ""source_locator"": ""Pathway[@frameid='PWY-5744']/reaction-list/Reaction[@frameid='RXN0-5055']""}, {""reference_id"": ""MetaCyc:RXN0-5055"", ""source_assertion"": ""The native carboxyl-transfer equation transfers a carboxyl group from protein-bound carboxybiotin to acetyl-CoA. Current Rhea retains generic whole protein carrier states."", ""source_locator"": ""Reaction[@detail=\""full\""]/left; right""}, {""reference_id"": ""RHEA:54729"", ""source_assertion"": ""Rhea master 54728 explicitly links directed member 54729; the selected sides follow the glyoxylate-assimilation cycle."", ""source_locator"": ""http://rdf.rhea-db.org/54728 rh:directionalReaction http://rdf.rhea-db.org/54729; http://rdf.rhea-db.org/54729 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5744"", ""source_sha256"": ""ae581b84fcd4a23a9968124b963f740179d11717099ab6007cd9ba3afa87f9a2"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""glyoxylate assimilation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5744""}, {""id"": ""MetaCyc:RXN0-5055"", ""source_sha256"": ""7962754112f02260c380c8ee7e5807bf4333ec5c2325852071e114c4884176ed"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""RXN0-5055"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5055""}, {""id"": ""RHEA:54729"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA => N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-058_6f57be063883	MetaCyc:PWY-5744	BFO:0000051	RHEA:26448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5744|MetaCyc:RXN-8963|RHEA:26448	All native pathway members are retained; normalized current chemical forms are not blanket exact mappings of native structures.	"[{""reference_id"": ""MetaCyc:PWY-5744"", ""source_assertion"": ""PWY-5744 explicitly lists RXN-8963 among its 13 native reaction objects."", ""source_locator"": ""Pathway[@frameid='PWY-5744']/reaction-list/Reaction[@frameid='RXN-8963']""}, {""reference_id"": ""MetaCyc:RXN-8963"", ""source_assertion"": ""The native reaction links Rhea 26449; current family/direction and chemical structure are verified separately."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea master 26446 explicitly links directed member 26448; the selected sides follow the glyoxylate-assimilation cycle."", ""source_locator"": ""http://rdf.rhea-db.org/26446 rh:directionalReaction http://rdf.rhea-db.org/26448; http://rdf.rhea-db.org/26448 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5744"", ""source_sha256"": ""ae581b84fcd4a23a9968124b963f740179d11717099ab6007cd9ba3afa87f9a2"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""glyoxylate assimilation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5744""}, {""id"": ""MetaCyc:RXN-8963"", ""source_sha256"": ""f0e6b1ac76f3081d1701c4504a9b47a32dd6b325539447e0148ffc48cacaa154"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""RXN-8963"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8963""}, {""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""malonyl-CoA + NADPH + H(+) => 3-oxopropanoate + NADP(+) + CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-059_8b37a17202d2	MetaCyc:PWY-5744	BFO:0000051	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5744|MetaCyc:RXN-8974|RHEA:26440	All native pathway members are retained; normalized current chemical forms are not blanket exact mappings of native structures.	"[{""reference_id"": ""MetaCyc:PWY-5744"", ""source_assertion"": ""PWY-5744 explicitly lists RXN-8974 among its 13 native reaction objects."", ""source_locator"": ""Pathway[@frameid='PWY-5744']/reaction-list/Reaction[@frameid='RXN-8974']""}, {""reference_id"": ""MetaCyc:RXN-8974"", ""source_assertion"": ""The native reaction links Rhea 26440; current family/direction and chemical structure are verified separately."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea master 26438 explicitly links directed member 26440; the selected sides follow the glyoxylate-assimilation cycle."", ""source_locator"": ""http://rdf.rhea-db.org/26438 rh:directionalReaction http://rdf.rhea-db.org/26440; http://rdf.rhea-db.org/26440 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5744"", ""source_sha256"": ""ae581b84fcd4a23a9968124b963f740179d11717099ab6007cd9ba3afa87f9a2"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""glyoxylate assimilation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5744""}, {""id"": ""MetaCyc:RXN-8974"", ""source_sha256"": ""ddb5c15214b2047cc5aeae0076f7fc8783861858b628c566363887a83208a824"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""RXN-8974"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8974""}, {""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-060_cd5fe5e26ee7	MetaCyc:PWY-5744	BFO:0000051	RHEA:26535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5744|MetaCyc:RXN-9086|RHEA:26535	All native pathway members are retained; normalized current chemical forms are not blanket exact mappings of native structures.	"[{""reference_id"": ""MetaCyc:PWY-5744"", ""source_assertion"": ""PWY-5744 explicitly lists RXN-9086 among its 13 native reaction objects."", ""source_locator"": ""Pathway[@frameid='PWY-5744']/reaction-list/Reaction[@frameid='RXN-9086']""}, {""reference_id"": ""MetaCyc:RXN-9086"", ""source_assertion"": ""The native reaction links Rhea 26535; current family/direction and chemical structure are verified separately."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea master 26534 explicitly links directed member 26535; the selected sides follow the glyoxylate-assimilation cycle."", ""source_locator"": ""http://rdf.rhea-db.org/26534 rh:directionalReaction http://rdf.rhea-db.org/26535; http://rdf.rhea-db.org/26535 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5744"", ""source_sha256"": ""ae581b84fcd4a23a9968124b963f740179d11717099ab6007cd9ba3afa87f9a2"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""glyoxylate assimilation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5744""}, {""id"": ""MetaCyc:RXN-9086"", ""source_sha256"": ""b5cfb7a4cae84f5203e562f4a58aa6fc02b3af5532953d0d7249745499f2c791"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""RXN-9086"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9086""}, {""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-061_49d31bfb5bc6	MetaCyc:PWY-5744	BFO:0000051	RHEA:26519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5744|MetaCyc:RXN-6383|RHEA:26519	All native pathway members are retained; normalized current chemical forms are not blanket exact mappings of native structures.	"[{""reference_id"": ""MetaCyc:PWY-5744"", ""source_assertion"": ""PWY-5744 explicitly lists RXN-6383 among its 13 native reaction objects."", ""source_locator"": ""Pathway[@frameid='PWY-5744']/reaction-list/Reaction[@frameid='RXN-6383']""}, {""reference_id"": ""MetaCyc:RXN-6383"", ""source_assertion"": ""The native reaction links Rhea 26518; current family/direction and chemical structure are verified separately."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:26519"", ""source_assertion"": ""Rhea master 26518 explicitly links directed member 26519; the selected sides follow the glyoxylate-assimilation cycle."", ""source_locator"": ""http://rdf.rhea-db.org/26518 rh:directionalReaction http://rdf.rhea-db.org/26519; http://rdf.rhea-db.org/26519 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5744"", ""source_sha256"": ""ae581b84fcd4a23a9968124b963f740179d11717099ab6007cd9ba3afa87f9a2"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""glyoxylate assimilation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5744""}, {""id"": ""MetaCyc:RXN-6383"", ""source_sha256"": ""ca3f42be810f2d950159b350849efcc45a3d5299c860b1e7398b13370878f5fe"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""RXN-6383"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-6383""}, {""id"": ""RHEA:26519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-hydroxypropanoyl-CoA => acryloyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-062_53f8b3c3a195	MetaCyc:PWY-5744	BFO:0000051	RHEA:26456	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5744|MetaCyc:RXN-9087|RHEA:26456	All native pathway members are retained; normalized current chemical forms are not blanket exact mappings of native structures.	"[{""reference_id"": ""MetaCyc:PWY-5744"", ""source_assertion"": ""PWY-5744 explicitly lists RXN-9087 among its 13 native reaction objects."", ""source_locator"": ""Pathway[@frameid='PWY-5744']/reaction-list/Reaction[@frameid='RXN-9087']""}, {""reference_id"": ""MetaCyc:RXN-9087"", ""source_assertion"": ""The native reaction links Rhea 26456; current family/direction and chemical structure are verified separately."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea master 26454 explicitly links directed member 26456; the selected sides follow the glyoxylate-assimilation cycle."", ""source_locator"": ""http://rdf.rhea-db.org/26454 rh:directionalReaction http://rdf.rhea-db.org/26456; http://rdf.rhea-db.org/26456 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5744"", ""source_sha256"": ""ae581b84fcd4a23a9968124b963f740179d11717099ab6007cd9ba3afa87f9a2"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""glyoxylate assimilation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5744""}, {""id"": ""MetaCyc:RXN-9087"", ""source_sha256"": ""1f715ecd994c074e00fe02f4fbbbc58cea6f090ef85eb54516687984683f3b70"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""RXN-9087"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9087""}, {""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""acryloyl-CoA + NADPH + H(+) => propanoyl-CoA + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-063_deb85065ce28	MetaCyc:PWY-5744	BFO:0000051	RHEA:38261	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5744|MetaCyc:RXN-8961|RHEA:38261	All native pathway members are retained; normalized current chemical forms are not blanket exact mappings of native structures.	"[{""reference_id"": ""MetaCyc:PWY-5744"", ""source_assertion"": ""PWY-5744 explicitly lists RXN-8961 among its 13 native reaction objects."", ""source_locator"": ""Pathway[@frameid='PWY-5744']/reaction-list/Reaction[@frameid='RXN-8961']""}, {""reference_id"": ""MetaCyc:RXN-8961"", ""source_assertion"": ""The native reaction links Rhea 38262; current family/direction and chemical structure are verified separately."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:38261"", ""source_assertion"": ""Rhea master 38259 explicitly links directed member 38261; the selected sides follow the glyoxylate-assimilation cycle."", ""source_locator"": ""http://rdf.rhea-db.org/38259 rh:directionalReaction http://rdf.rhea-db.org/38261; http://rdf.rhea-db.org/38261 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5744"", ""source_sha256"": ""ae581b84fcd4a23a9968124b963f740179d11717099ab6007cd9ba3afa87f9a2"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""glyoxylate assimilation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5744""}, {""id"": ""MetaCyc:RXN-8961"", ""source_sha256"": ""d622e2249d51595f292ab26de0c26fcdbf8ab422fdea573c50eece6f68775507"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""RXN-8961"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8961""}, {""id"": ""RHEA:38261"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""propanoyl-CoA + glyoxylate => (2R,3S)-beta-methylmalyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-064_72fac82e1d52	MetaCyc:PWY-5744	BFO:0000051	RHEA:38264	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5744|MetaCyc:RXN-8960|RHEA:38264	All native pathway members are retained; normalized current chemical forms are not blanket exact mappings of native structures.	"[{""reference_id"": ""MetaCyc:PWY-5744"", ""source_assertion"": ""PWY-5744 explicitly lists RXN-8960 among its 13 native reaction objects."", ""source_locator"": ""Pathway[@frameid='PWY-5744']/reaction-list/Reaction[@frameid='RXN-8960']""}, {""reference_id"": ""MetaCyc:RXN-8960"", ""source_assertion"": ""The native reaction links Rhea 38266; current family/direction and chemical structure are verified separately."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:38264"", ""source_assertion"": ""Rhea master 38263 explicitly links directed member 38264; the selected sides follow the glyoxylate-assimilation cycle."", ""source_locator"": ""http://rdf.rhea-db.org/38263 rh:directionalReaction http://rdf.rhea-db.org/38264; http://rdf.rhea-db.org/38264 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5744"", ""source_sha256"": ""ae581b84fcd4a23a9968124b963f740179d11717099ab6007cd9ba3afa87f9a2"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""glyoxylate assimilation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5744""}, {""id"": ""MetaCyc:RXN-8960"", ""source_sha256"": ""ddddbfeb801d6722a95252238703c8157e6ffa1550a501a6cd4fcc7d4ee216ba"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""RXN-8960"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8960""}, {""id"": ""RHEA:38264"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""(2R,3S)-beta-methylmalyl-CoA => 2-methylfumaryl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-065_5f7ef6d9df9b	MetaCyc:PWY-5744	BFO:0000051	RHEA:38268	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5744|MetaCyc:RXN-13230|RHEA:38268	All native pathway members are retained; normalized current chemical forms are not blanket exact mappings of native structures.	"[{""reference_id"": ""MetaCyc:PWY-5744"", ""source_assertion"": ""PWY-5744 explicitly lists RXN-13230 among its 13 native reaction objects."", ""source_locator"": ""Pathway[@frameid='PWY-5744']/reaction-list/Reaction[@frameid='RXN-13230']""}, {""reference_id"": ""MetaCyc:RXN-13230"", ""source_assertion"": ""The native reaction links Rhea 38270; current family/direction and chemical structure are verified separately."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:38268"", ""source_assertion"": ""Rhea master 38267 explicitly links directed member 38268; the selected sides follow the glyoxylate-assimilation cycle."", ""source_locator"": ""http://rdf.rhea-db.org/38267 rh:directionalReaction http://rdf.rhea-db.org/38268; http://rdf.rhea-db.org/38268 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5744"", ""source_sha256"": ""ae581b84fcd4a23a9968124b963f740179d11717099ab6007cd9ba3afa87f9a2"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""glyoxylate assimilation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5744""}, {""id"": ""MetaCyc:RXN-13230"", ""source_sha256"": ""a61ab86de13abe8f595efc3b8f420b14b12999dd99aa5985e17cb1992622b183"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""RXN-13230"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-13230""}, {""id"": ""RHEA:38268"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""2-methylfumaryl-CoA => 3-methylfumaryl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-066_a3add163c8da	MetaCyc:PWY-5744	BFO:0000051	RHEA:38273	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5744|MetaCyc:RXN-8965|RHEA:38273	All native pathway members are retained; normalized current chemical forms are not blanket exact mappings of native structures.	"[{""reference_id"": ""MetaCyc:PWY-5744"", ""source_assertion"": ""PWY-5744 explicitly lists RXN-8965 among its 13 native reaction objects."", ""source_locator"": ""Pathway[@frameid='PWY-5744']/reaction-list/Reaction[@frameid='RXN-8965']""}, {""reference_id"": ""MetaCyc:RXN-8965"", ""source_assertion"": ""The native equation stores CPD-627 on the left and CPD-14205 plus WATER on the right, with RIGHT-TO-LEFT physiological direction, supporting mesaconyl-C4-CoA hydration to (S)-citramalyl-CoA."", ""source_locator"": ""Reaction[@detail=\""full\""]/left; right; reaction-direction""}, {""reference_id"": ""RHEA:38273"", ""source_assertion"": ""Rhea master 38271 explicitly links directed member 38273; the selected sides follow the glyoxylate-assimilation cycle."", ""source_locator"": ""http://rdf.rhea-db.org/38271 rh:directionalReaction http://rdf.rhea-db.org/38273; http://rdf.rhea-db.org/38273 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-5744"", ""source_sha256"": ""ae581b84fcd4a23a9968124b963f740179d11717099ab6007cd9ba3afa87f9a2"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""glyoxylate assimilation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5744""}, {""id"": ""MetaCyc:RXN-8965"", ""source_sha256"": ""80aeedc50b829d6b556452268c16265d38602828453e8214d7445f5071c4f9d2"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""RXN-8965"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8965""}, {""id"": ""RHEA:38273"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-methylfumaryl-CoA + H2O => (3S)-citramalyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-067_86f2e58a0812	MetaCyc:PWY-5744	BFO:0000051	RHEA:22613	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CITRAMALYL-COA-LYASE-RXN|MetaCyc:PWY-5744|RHEA:22613	All native pathway members are retained; normalized current chemical forms are not blanket exact mappings of native structures.	"[{""reference_id"": ""MetaCyc:PWY-5744"", ""source_assertion"": ""PWY-5744 explicitly lists CITRAMALYL-COA-LYASE-RXN among its 13 native reaction objects."", ""source_locator"": ""Pathway[@frameid='PWY-5744']/reaction-list/Reaction[@frameid='CITRAMALYL-COA-LYASE-RXN']""}, {""reference_id"": ""MetaCyc:CITRAMALYL-COA-LYASE-RXN"", ""source_assertion"": ""The native reaction links Rhea 22615; current family/direction and chemical structure are verified separately."", ""source_locator"": ""Reaction[@detail='full']/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:22613"", ""source_assertion"": ""Rhea master 22612 explicitly links directed member 22613; the selected sides follow the glyoxylate-assimilation cycle."", ""source_locator"": ""http://rdf.rhea-db.org/22612 rh:directionalReaction http://rdf.rhea-db.org/22613; http://rdf.rhea-db.org/22613 rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:CITRAMALYL-COA-LYASE-RXN"", ""source_sha256"": ""f7b6c5233098cae535041eccf1ef6808baa9c4146fac737f4f88ae41712c6702"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""CITRAMALYL-COA-LYASE-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CITRAMALYL-COA-LYASE-RXN""}, {""id"": ""MetaCyc:PWY-5744"", ""source_sha256"": ""ae581b84fcd4a23a9968124b963f740179d11717099ab6007cd9ba3afa87f9a2"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""glyoxylate assimilation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5744""}, {""id"": ""RHEA:22613"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""(3S)-citramalyl-CoA => pyruvate + acetyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-068_1a3ef6faea89	UniProtKB:A9W9X0	pathwaymech:enables	RHEA:13502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:38572988|UniProtKB:A9W9X0	J-10-fl BC1 has a fused BCCP domain and a tetrameric biological assembly. This functional relation does not imply monomer sufficiency or fixed whole-ACC stoichiometry.	"[{""reference_id"": ""PMID:38572988"", ""source_assertion"": ""Caur_1378 BC1 is 596 residues with fused BC/BCCP domains; the biotinylated construct performs biotin-carboxylase/carrier functions, and solution and crystal measurements support a tetramer."", ""source_locator"": ""Results s2-1–s2-4; Methods s4-1, s4-3–s4-5, s4-8""}, {""reference_id"": ""UniProtKB:A9W9X0"", ""source_assertion"": ""The current J-10-fl accession is the 596-residue Caur_1378 biotin carboxylase. Evidence tier: ECO:0000256."", ""source_locator"": ""/proteinDescription; /genes; /organism; /sequence""}]"	"[{""id"": ""PMID:38572988"", ""source_sha256"": ""8c8e6fcde50943d0fb4e771af6a39259541d5feb3d08747ed0077302616bddd6"", ""source_version"": ""Complete original primary full-text body retrieved 2026-10-11; strain and construct limits retained"", ""title"": ""Chloroflexus aurantiacus acetyl-CoA carboxylase evolves fused biotin carboxylase and biotin carboxyl carrier protein to complete carboxylation activity"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC11077971/""}, {""id"": ""UniProtKB:A9W9X0"", ""source_sha256"": ""5784ed335a0e688a35a9a7ba765695e73b97a8c06ed75fd883a7b17505bb77e4"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 97, sequence version 1, annotation date 2026-09-02"", ""title"": ""biotin carboxylase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9W9X0.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-069_8561b6de2033	UniProtKB:A9WBQ8	pathwaymech:enables	RHEA:54729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:A9WBQ8	Inferred functional component of the joint alpha/beta carboxyltransferase, not an independently sufficient subunit. The 2024 Methods swaps locus/chain labels, so its exact individual CT construct bridge is not asserted.	"[{""reference_id"": ""UniProtKB:A9WBQ8"", ""source_assertion"": ""The current HAMAP-backed annotation assigns protein-bound carboxybiotin/acetyl-CoA carboxyltransferase activity Rhea54728. This is an inferred exact-accession function. Evidence tier: ECO:0000256."", ""source_locator"": ""/comments/0/texts; /comments/1/reaction; /comments/1/reaction/evidences""}]"	"[{""id"": ""UniProtKB:A9WBQ8"", ""source_sha256"": ""02c00ad67438d57e4bd45ded8fe0dc8a2513211e3c40d63c1c69f808e705e217"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 113, sequence version 1, annotation date 2026-09-02"", ""title"": ""Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9WBQ8.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-070_f71bd9b21f2f	UniProtKB:A9WBQ9	pathwaymech:enables	RHEA:54729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:A9WBQ9	Inferred functional component of the joint alpha/beta carboxyltransferase, not an independently sufficient subunit. The 2024 Methods swaps locus/chain labels, so its exact individual CT construct bridge is not asserted.	"[{""reference_id"": ""UniProtKB:A9WBQ9"", ""source_assertion"": ""The current HAMAP-backed annotation assigns protein-bound carboxybiotin/acetyl-CoA carboxyltransferase activity Rhea54728. This is an inferred exact-accession function. Evidence tier: ECO:0000255."", ""source_locator"": ""/comments/0/texts; /comments/1/reaction; /comments/1/reaction/evidences""}]"	"[{""id"": ""UniProtKB:A9WBQ9"", ""source_sha256"": ""648805f6552d26a8fd62c5b84a8b7921d4a1c2d8302c9a15f50d64e7d1c1307a"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 87, sequence version 1, annotation date 2026-09-02"", ""title"": ""Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9WBQ9.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-071_54ae4349ceeb	MetaCyc:CPLX-7550	pathwaymech:catalyzes	RHEA:26448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7550|PMID:11948153	Bacterial bifunctional MCR: two NADPH-dependent partial reactions via malonate semialdehyde. The physiological metal is unresolved; metal stimulation does not establish a unique occupied cofactor.	"[{""reference_id"": ""PMID:11948153"", ""source_assertion"": ""Purified OK-70-fl MCR reduces malonyl-CoA via malonate semialdehyde to 3-hydroxypropionate using two NADPH. Semicarbazide trapping and radiolabel/HPLC support the intermediate and two partial reductions."", ""source_locator"": ""Results sec21–sec23; Discussion sec27–sec29""}, {""reference_id"": ""MetaCyc:CPLX-7550"", ""source_assertion"": ""The native bacterial bifunctional MCR complex has two subunits."", ""source_locator"": ""Protein[@frameid=\""CPLX-7550\""]/comment; component""}]"	"[{""id"": ""MetaCyc:CPLX-7550"", ""source_sha256"": ""0ac61e64c1f21f367b0e3c8e960036424d8a4a0e49df8e469fd281b84892aa2c"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""malonyl CoA reductase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7550""}, {""id"": ""PMID:11948153"", ""source_sha256"": ""12ba378e029f66faa57dd0eb3c689efad7eddbf6e1d3adf3cd143fda9e6d39c0"", ""source_version"": ""Complete original primary full-text body retrieved 2026-10-11; strain and construct limits retained"", ""title"": ""Malonyl-Coenzyme A Reductase from Chloroflexus aurantiacus, a Key Enzyme of the 3-Hydroxypropionate Cycle for Autotrophic CO2 Fixation"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC134993/""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-072_a75a672c6361	MetaCyc:CPLX-7550	pathwaymech:catalyzes	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7550|PMID:11948153	Bacterial bifunctional MCR: two NADPH-dependent partial reactions via malonate semialdehyde. The physiological metal is unresolved; metal stimulation does not establish a unique occupied cofactor.	"[{""reference_id"": ""PMID:11948153"", ""source_assertion"": ""Purified OK-70-fl MCR reduces malonyl-CoA via malonate semialdehyde to 3-hydroxypropionate using two NADPH. Semicarbazide trapping and radiolabel/HPLC support the intermediate and two partial reductions."", ""source_locator"": ""Results sec21–sec23; Discussion sec27–sec29""}, {""reference_id"": ""MetaCyc:CPLX-7550"", ""source_assertion"": ""The native bacterial bifunctional MCR complex has two subunits."", ""source_locator"": ""Protein[@frameid=\""CPLX-7550\""]/comment; component""}]"	"[{""id"": ""MetaCyc:CPLX-7550"", ""source_sha256"": ""0ac61e64c1f21f367b0e3c8e960036424d8a4a0e49df8e469fd281b84892aa2c"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""malonyl CoA reductase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7550""}, {""id"": ""PMID:11948153"", ""source_sha256"": ""12ba378e029f66faa57dd0eb3c689efad7eddbf6e1d3adf3cd143fda9e6d39c0"", ""source_version"": ""Complete original primary full-text body retrieved 2026-10-11; strain and construct limits retained"", ""title"": ""Malonyl-Coenzyme A Reductase from Chloroflexus aurantiacus, a Key Enzyme of the 3-Hydroxypropionate Cycle for Autotrophic CO2 Fixation"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC134993/""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-073_596aefb4fd1f	MetaCyc:CPLX-7550	BFO:0000051	UniProtKB:Q6QQP7	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11948153|UniProtKB:Q6QQP7	Two equivalent OK-70-fl MCR chains in the experimentally characterized dimer. Native J-10-fl A9WIU3 is a distinct sequence; Q6QQP7 is independently primary-linked, without strain equivalence.	"[{""reference_id"": ""PMID:11948153"", ""source_assertion"": ""Purified OK-70-fl MCR had a 145-kDa subunit and about 300-kDa native mass; its reported N-terminal sequence corresponds to the bifunctional SDR-like enzyme."", ""source_locator"": ""Methods sec2; Results sec21; Discussion sec29""}, {""reference_id"": ""UniProtKB:Q6QQP7"", ""source_assertion"": ""The sequence record links OK-70-fl, the primary MCR paper and the 2004 sequence submission AY530019/AAS20429.1. Evidence tier: ECO:0000313."", ""source_locator"": ""/references/0; /references/1; /uniProtKBCrossReferences[database=EMBL]; /sequence""}]"	"[{""id"": ""PMID:11948153"", ""source_sha256"": ""12ba378e029f66faa57dd0eb3c689efad7eddbf6e1d3adf3cd143fda9e6d39c0"", ""source_version"": ""Complete original primary full-text body retrieved 2026-10-11; strain and construct limits retained"", ""title"": ""Malonyl-Coenzyme A Reductase from Chloroflexus aurantiacus, a Key Enzyme of the 3-Hydroxypropionate Cycle for Autotrophic CO2 Fixation"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC134993/""}, {""id"": ""UniProtKB:Q6QQP7"", ""source_sha256"": ""4379c5ce7466af5819a242392b851a3cbcc974e504dc36340613f05d482febd1"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 90, sequence version 1, annotation date 2025-06-18"", ""title"": ""Malonyl-CoA reductase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q6QQP7.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-074_4f1cbf5481d0	UniProtKB:Q8VRG6	pathwaymech:enables	RHEA:26535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7552|MetaCyc:MONOMER-13612|NCBIProtein:AAL47820.2|PMID:11821399|UniProtKB:Q8VRG6	OK-70-fl trifunctional PCS has a native three-or-four-subunit estimate; no unique complex stoichiometry or monomer sufficiency is asserted. The automated acetate-CoA-ligase label is retained as a label, not adopted as its inspected physiological function.	"[{""reference_id"": ""MetaCyc:CPLX-7552"", ""source_assertion"": ""The native PCS complex describes all three 3-hydroxypropanoate-to-propanoyl-CoA activities and a native assembly of three or four identical subunits."", ""source_locator"": ""Protein[@frameid=\""CPLX-7552\""]/comment; catalyzes""}, {""reference_id"": ""MetaCyc:MONOMER-13612"", ""source_assertion"": ""The native PCS component explicitly cross-references Q8VRG6 as well as the distinct J-10-fl accession A9WEU4."", ""source_locator"": ""Protein[@frameid=\""MONOMER-13612\""]/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""NCBIProtein:AAL47820.2"", ""source_assertion"": ""The deposited 1822-residue propionyl-CoA synthase derives from strain OK-70-fl and the AF445079 nucleotide record; its annotated product is a three-domain fusion. Evidence tier: ECO:0000313."", ""source_locator"": ""GBSeq/GBSeq_accession-version; GBSeq_feature-table; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q8VRG6"", ""source_assertion"": ""The primary-linked OK-70-fl PCS sequence cross-references AF445079/AAL47820.2; comparison with the original deposited protein sequence is exact. Evidence tier: ECO:0000313."", ""source_locator"": ""/references; /uniProtKBCrossReferences[database=EMBL]; /sequence""}, {""reference_id"": ""PMID:11821399"", ""source_assertion"": ""Purified PCS couples ATP-dependent 3-hydroxypropionate activation to dehydration and NADPH-dependent reduction, yielding propionyl-CoA, AMP and pyrophosphate."", ""source_locator"": ""Results: Stoichiometry and Products of the Reaction; Possible Intermediates; Domain Character of Propionyl-CoA Synthase""}]"	"[{""id"": ""MetaCyc:CPLX-7552"", ""source_sha256"": ""f90283f0a3ab61d6ef9db72355a659e7380d762ba09660fc8a973dd8a7c5cbf6"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""propionyl-CoA synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7552""}, {""id"": ""MetaCyc:MONOMER-13612"", ""source_sha256"": ""f41e27eb69eb3c1949db94906081c3be82ba75a84701d3e997f2c9a684b4f99b"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""propionyl-CoA synthase subunit"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-13612""}, {""id"": ""NCBIProtein:AAL47820.2"", ""source_sha256"": ""ac72cc5e8786cf8c5d8e37696a10d425257c30d8426dc6e52691e0717d639ec3"", ""source_version"": ""Complete original accession-version protein XML retrieved 2026-10-11"", ""title"": ""Propionyl-CoA synthase [Chloroflexus aurantiacus]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAL47820.2&rettype=gb&retmode=xml""}, {""id"": ""PMID:11821399"", ""source_version"": ""Primary full-text copy inspected through web rendering 2026-10-11; local publisher and author-copy downloads returned 403; no body digest or local full-text replay claimed"", ""title"": ""Propionyl-coenzyme A synthase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO2 fixation"", ""url"": ""https://doi.org/10.1074/jbc.M110802200""}, {""id"": ""UniProtKB:Q8VRG6"", ""source_sha256"": ""0f4a1210bd6445758b8d59a05c6d4bf6598d629f95fa55abaee4eb77f994f3dd"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 105, sequence version 2, annotation date 2026-09-02"", ""title"": ""acetate--CoA ligase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q8VRG6.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-075_77116db44501	UniProtKB:Q8VRG6	pathwaymech:enables	RHEA:26519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7552|MetaCyc:MONOMER-13612|NCBIProtein:AAL47820.2|PMID:11821399|UniProtKB:Q8VRG6	OK-70-fl trifunctional PCS has a native three-or-four-subunit estimate; no unique complex stoichiometry or monomer sufficiency is asserted. The automated acetate-CoA-ligase label is retained as a label, not adopted as its inspected physiological function.	"[{""reference_id"": ""MetaCyc:CPLX-7552"", ""source_assertion"": ""The native PCS complex describes all three 3-hydroxypropanoate-to-propanoyl-CoA activities and a native assembly of three or four identical subunits."", ""source_locator"": ""Protein[@frameid=\""CPLX-7552\""]/comment; catalyzes""}, {""reference_id"": ""MetaCyc:MONOMER-13612"", ""source_assertion"": ""The native PCS component explicitly cross-references Q8VRG6 as well as the distinct J-10-fl accession A9WEU4."", ""source_locator"": ""Protein[@frameid=\""MONOMER-13612\""]/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""NCBIProtein:AAL47820.2"", ""source_assertion"": ""The deposited 1822-residue propionyl-CoA synthase derives from strain OK-70-fl and the AF445079 nucleotide record; its annotated product is a three-domain fusion. Evidence tier: ECO:0000313."", ""source_locator"": ""GBSeq/GBSeq_accession-version; GBSeq_feature-table; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q8VRG6"", ""source_assertion"": ""The primary-linked OK-70-fl PCS sequence cross-references AF445079/AAL47820.2; comparison with the original deposited protein sequence is exact. Evidence tier: ECO:0000313."", ""source_locator"": ""/references; /uniProtKBCrossReferences[database=EMBL]; /sequence""}, {""reference_id"": ""PMID:11821399"", ""source_assertion"": ""Purified PCS couples ATP-dependent 3-hydroxypropionate activation to dehydration and NADPH-dependent reduction, yielding propionyl-CoA, AMP and pyrophosphate."", ""source_locator"": ""Results: Stoichiometry and Products of the Reaction; Possible Intermediates; Domain Character of Propionyl-CoA Synthase""}]"	"[{""id"": ""MetaCyc:CPLX-7552"", ""source_sha256"": ""f90283f0a3ab61d6ef9db72355a659e7380d762ba09660fc8a973dd8a7c5cbf6"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""propionyl-CoA synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7552""}, {""id"": ""MetaCyc:MONOMER-13612"", ""source_sha256"": ""f41e27eb69eb3c1949db94906081c3be82ba75a84701d3e997f2c9a684b4f99b"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""propionyl-CoA synthase subunit"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-13612""}, {""id"": ""NCBIProtein:AAL47820.2"", ""source_sha256"": ""ac72cc5e8786cf8c5d8e37696a10d425257c30d8426dc6e52691e0717d639ec3"", ""source_version"": ""Complete original accession-version protein XML retrieved 2026-10-11"", ""title"": ""Propionyl-CoA synthase [Chloroflexus aurantiacus]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAL47820.2&rettype=gb&retmode=xml""}, {""id"": ""PMID:11821399"", ""source_version"": ""Primary full-text copy inspected through web rendering 2026-10-11; local publisher and author-copy downloads returned 403; no body digest or local full-text replay claimed"", ""title"": ""Propionyl-coenzyme A synthase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO2 fixation"", ""url"": ""https://doi.org/10.1074/jbc.M110802200""}, {""id"": ""UniProtKB:Q8VRG6"", ""source_sha256"": ""0f4a1210bd6445758b8d59a05c6d4bf6598d629f95fa55abaee4eb77f994f3dd"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 105, sequence version 2, annotation date 2026-09-02"", ""title"": ""acetate--CoA ligase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q8VRG6.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-076_bb2a3a5c351e	UniProtKB:Q8VRG6	pathwaymech:enables	RHEA:26456	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7552|MetaCyc:MONOMER-13612|NCBIProtein:AAL47820.2|PMID:11821399|UniProtKB:Q8VRG6	OK-70-fl trifunctional PCS has a native three-or-four-subunit estimate; no unique complex stoichiometry or monomer sufficiency is asserted. The automated acetate-CoA-ligase label is retained as a label, not adopted as its inspected physiological function.	"[{""reference_id"": ""MetaCyc:CPLX-7552"", ""source_assertion"": ""The native PCS complex describes all three 3-hydroxypropanoate-to-propanoyl-CoA activities and a native assembly of three or four identical subunits."", ""source_locator"": ""Protein[@frameid=\""CPLX-7552\""]/comment; catalyzes""}, {""reference_id"": ""MetaCyc:MONOMER-13612"", ""source_assertion"": ""The native PCS component explicitly cross-references Q8VRG6 as well as the distinct J-10-fl accession A9WEU4."", ""source_locator"": ""Protein[@frameid=\""MONOMER-13612\""]/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""NCBIProtein:AAL47820.2"", ""source_assertion"": ""The deposited 1822-residue propionyl-CoA synthase derives from strain OK-70-fl and the AF445079 nucleotide record; its annotated product is a three-domain fusion. Evidence tier: ECO:0000313."", ""source_locator"": ""GBSeq/GBSeq_accession-version; GBSeq_feature-table; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q8VRG6"", ""source_assertion"": ""The primary-linked OK-70-fl PCS sequence cross-references AF445079/AAL47820.2; comparison with the original deposited protein sequence is exact. Evidence tier: ECO:0000313."", ""source_locator"": ""/references; /uniProtKBCrossReferences[database=EMBL]; /sequence""}, {""reference_id"": ""PMID:11821399"", ""source_assertion"": ""Purified PCS couples ATP-dependent 3-hydroxypropionate activation to dehydration and NADPH-dependent reduction, yielding propionyl-CoA, AMP and pyrophosphate."", ""source_locator"": ""Results: Stoichiometry and Products of the Reaction; Possible Intermediates; Domain Character of Propionyl-CoA Synthase""}]"	"[{""id"": ""MetaCyc:CPLX-7552"", ""source_sha256"": ""f90283f0a3ab61d6ef9db72355a659e7380d762ba09660fc8a973dd8a7c5cbf6"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""propionyl-CoA synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7552""}, {""id"": ""MetaCyc:MONOMER-13612"", ""source_sha256"": ""f41e27eb69eb3c1949db94906081c3be82ba75a84701d3e997f2c9a684b4f99b"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""propionyl-CoA synthase subunit"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-13612""}, {""id"": ""NCBIProtein:AAL47820.2"", ""source_sha256"": ""ac72cc5e8786cf8c5d8e37696a10d425257c30d8426dc6e52691e0717d639ec3"", ""source_version"": ""Complete original accession-version protein XML retrieved 2026-10-11"", ""title"": ""Propionyl-CoA synthase [Chloroflexus aurantiacus]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAL47820.2&rettype=gb&retmode=xml""}, {""id"": ""PMID:11821399"", ""source_version"": ""Primary full-text copy inspected through web rendering 2026-10-11; local publisher and author-copy downloads returned 403; no body digest or local full-text replay claimed"", ""title"": ""Propionyl-coenzyme A synthase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO2 fixation"", ""url"": ""https://doi.org/10.1074/jbc.M110802200""}, {""id"": ""UniProtKB:Q8VRG6"", ""source_sha256"": ""0f4a1210bd6445758b8d59a05c6d4bf6598d629f95fa55abaee4eb77f994f3dd"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 105, sequence version 2, annotation date 2026-09-02"", ""title"": ""acetate--CoA ligase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q8VRG6.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-077_7ad152ff5e0e	MetaCyc:CPLX-7549	pathwaymech:catalyzes	RHEA:38261	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19955419|UniProtKB:S5N020	The same hexameric Mcl catalyzes both glyoxylate/propionyl-CoA condensation and S-citramalyl-CoA cleavage; R-citramalyl-CoA is excluded by the primary assay.	"[{""reference_id"": ""UniProtKB:S5N020"", ""source_assertion"": ""Reviewed OK-70-fl Mcl assigns the selected beta-methylmalyl/citramalyl reaction with experimental evidence."", ""source_locator"": ""/comments/0/texts; /comments/2/reaction""}, {""reference_id"": ""PMID:19955419"", ""source_assertion"": ""Recombinant MMC lyase catalyzed propionyl-CoA condensation with glyoxylate and S-citramalyl-CoA cleavage. R-malyl-CoA and R-citramalyl-CoA were not substrates."", ""source_locator"": ""Results sec6; Figure 4""}]"	"[{""id"": ""PMID:19955419"", ""source_sha256"": ""ef7bbdc7b8ebc8cd62ae4d586fe953a767fdce2865900f742e43336381fde7b1"", ""source_version"": ""Complete original primary full-text body retrieved 2026-10-11; strain and construct limits retained"", ""title"": ""Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2795484/""}, {""id"": ""UniProtKB:S5N020"", ""source_sha256"": ""ee8c48a604f28f3967d40526eb452abb51d770277fc49caf368aaa274c581e02"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 45, sequence version 1, annotation date 2026-06-10"", ""title"": ""Malyl-CoA/beta-methylmalyl-CoA/citramalyl-CoA lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/S5N020.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-078_80fcfa8b3f43	MetaCyc:CPLX-7549	pathwaymech:catalyzes	RHEA:22613	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19955419|UniProtKB:S5N020	The same hexameric Mcl catalyzes both glyoxylate/propionyl-CoA condensation and S-citramalyl-CoA cleavage; R-citramalyl-CoA is excluded by the primary assay.	"[{""reference_id"": ""UniProtKB:S5N020"", ""source_assertion"": ""Reviewed OK-70-fl Mcl assigns the selected beta-methylmalyl/citramalyl reaction with experimental evidence."", ""source_locator"": ""/comments/0/texts; /comments/3/reaction""}, {""reference_id"": ""PMID:19955419"", ""source_assertion"": ""Recombinant MMC lyase catalyzed propionyl-CoA condensation with glyoxylate and S-citramalyl-CoA cleavage. R-malyl-CoA and R-citramalyl-CoA were not substrates."", ""source_locator"": ""Results sec6; Figure 4""}]"	"[{""id"": ""PMID:19955419"", ""source_sha256"": ""ef7bbdc7b8ebc8cd62ae4d586fe953a767fdce2865900f742e43336381fde7b1"", ""source_version"": ""Complete original primary full-text body retrieved 2026-10-11; strain and construct limits retained"", ""title"": ""Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2795484/""}, {""id"": ""UniProtKB:S5N020"", ""source_sha256"": ""ee8c48a604f28f3967d40526eb452abb51d770277fc49caf368aaa274c581e02"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 45, sequence version 1, annotation date 2026-06-10"", ""title"": ""Malyl-CoA/beta-methylmalyl-CoA/citramalyl-CoA lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/S5N020.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-079_c754181ff9da	MetaCyc:CPLX-7549	BFO:0000051	UniProtKB:S5N020	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7549|MetaCyc:MONOMER-13604|PMID:24206647|UniProtKB:S5N020	Six identical Mcl chains. Exact OK-70-fl S5N020 and native-mapped J-10-fl A9WC35 sequences are identical, but organism strain identities are not merged.	"[{""reference_id"": ""MetaCyc:CPLX-7549"", ""source_assertion"": ""The native Mcl assembly lists six copies of MONOMER-13604."", ""source_locator"": ""Protein[@frameid=\""CPLX-7549\""]/component""}, {""reference_id"": ""MetaCyc:MONOMER-13604"", ""source_assertion"": ""The native Mcl component explicitly links A9WC35."", ""source_locator"": ""Protein[@frameid=\""MONOMER-13604\""]/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""PMID:24206647"", ""source_assertion"": ""OK-70-fl Mcl AGR55786 (Table 1) had solution mass 228 +/- 15 kDa and a crystal homohexamer, organized as a dimer of trimers."", ""source_locator"": ""Table 1; Results sec6, sec9; Methods sec18""}, {""reference_id"": ""UniProtKB:S5N020"", ""source_assertion"": ""The reviewed OK-70-fl sequence links AGR55786.1/KF240561 and annotates the experimental homohexamer."", ""source_locator"": ""/references; /uniProtKBCrossReferences[database=EMBL]; /sequence; /comments/7/texts""}]"	"[{""id"": ""MetaCyc:CPLX-7549"", ""source_sha256"": ""d57f9f742ed9a5d34f892c430529186b7f3f6d83d516bf4b0301c402aca2e30f"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""L-malyl CoA lyase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7549""}, {""id"": ""MetaCyc:MONOMER-13604"", ""source_sha256"": ""912acc5803663610d2f0db16ae70e4ac52cf868c2ddcb8701a86b78ca4b43ad2"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""L-malyl CoA lyase subunit"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-13604""}, {""id"": ""PMID:24206647"", ""source_sha256"": ""6d3105856a321b6d6977c03686e497c97c6c965cd4da532049c538d4d7af34ad"", ""source_version"": ""Complete original primary full-text body retrieved 2026-10-11; strain and construct limits retained"", ""title"": ""The crystal structures of the tri-functional Chloroflexus aurantiacus and bi-functional Rhodobacter sphaeroides malyl-CoA lyases and comparison with CitE-like superfamily enzymes and malate synthases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3832036/""}, {""id"": ""UniProtKB:S5N020"", ""source_sha256"": ""ee8c48a604f28f3967d40526eb452abb51d770277fc49caf368aaa274c581e02"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 45, sequence version 1, annotation date 2026-06-10"", ""title"": ""Malyl-CoA/beta-methylmalyl-CoA/citramalyl-CoA lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/S5N020.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-080_eb0a7623d54d	MetaCyc:CPLX-8468	pathwaymech:catalyzes	RHEA:38264	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:18065535|UniProtKB:A9WC34	Native species-level dimer with reviewed current component attribution. Original pathway experiments used OK-70-fl and J-10-fl-guided primers; exact clone/genome equivalence is not presumed.	"[{""reference_id"": ""PMID:18065535"", ""source_assertion"": ""Recombinant C. aurantiacus Mch reversibly dehydrates erythro-beta-methylmalyl-CoA to mesaconyl-C1-CoA; HPLC/MS/NMR characterize the product."", ""source_locator"": ""Results sec28–sec37; Discussion sec38""}, {""reference_id"": ""UniProtKB:A9WC34"", ""source_assertion"": ""The current reviewed entry assigns this exact reaction family with experimental evidence; the primary functional reference identifies OK-70-fl while the genome-sequence reference identifies J-10-fl."", ""source_locator"": ""/comments/0/texts; /comments/1/reaction; /references/0; /references/1""}]"	"[{""id"": ""PMID:18065535"", ""source_sha256"": ""0fc19b8249d182c63e5c52125fa443d6783fd1225104520cc535e42c0efa2e3d"", ""source_version"": ""Complete original primary full-text body retrieved 2026-10-11; strain and construct limits retained"", ""title"": ""Mesaconyl-Coenzyme A Hydratase, a New Enzyme of Two Central Carbon Metabolic Pathways in Bacteria"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2238226/""}, {""id"": ""UniProtKB:A9WC34"", ""source_sha256"": ""38f2a1c20fb6cc0009ca1ac0033c9722c09e7747b2849995518543613725db3c"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 75, sequence version 1, annotation date 2026-06-10"", ""title"": ""Beta-methylmalyl-CoA dehydratase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9WC34.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-081_7c801d33b6e6	MetaCyc:CPLX-8468	BFO:0000051	UniProtKB:A9WC34	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8468|MetaCyc:MONOMER-17292|UniProtKB:A9WC34	Two copies of the native-mapped current component; the original biochemical construct and current genome strain remain explicitly distinguished.	"[{""reference_id"": ""MetaCyc:CPLX-8468"", ""source_assertion"": ""The native complex contains two copies of MONOMER-17292."", ""source_locator"": ""Protein[@frameid=\""CPLX-8468\""]/component""}, {""reference_id"": ""MetaCyc:MONOMER-17292"", ""source_assertion"": ""The native monomer cross-references UniProt A9WC34."", ""source_locator"": ""Protein[@frameid=\""MONOMER-17292\""]/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:A9WC34"", ""source_assertion"": ""The current subunit annotation is homodimer with experimental evidence."", ""source_locator"": ""/comments/3/texts""}]"	"[{""id"": ""MetaCyc:CPLX-8468"", ""source_sha256"": ""5c72238d306edf33232f204a2407b55c4ee16ca4c5191c09472d6adf48891812"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""β-methylmalyl-CoA dehydratase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8468""}, {""id"": ""MetaCyc:MONOMER-17292"", ""source_sha256"": ""7fbeded82e8b3e64a8e995666713645bbc2b558a5d4a2afe41ca27c4e0b13ce4"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""β-methylmalyl-CoA dehydratase monomer"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-17292""}, {""id"": ""UniProtKB:A9WC34"", ""source_sha256"": ""38f2a1c20fb6cc0009ca1ac0033c9722c09e7747b2849995518543613725db3c"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 75, sequence version 1, annotation date 2026-06-10"", ""title"": ""Beta-methylmalyl-CoA dehydratase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9WC34.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-082_1e09e5505c77	MetaCyc:CPLX-8466	pathwaymech:catalyzes	RHEA:38268	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19955419|PMID:36535006|UniProtKB:A9WC36	Native species-level dimer with reviewed current component attribution. Original pathway experiments used OK-70-fl and J-10-fl-guided primers; exact clone/genome equivalence is not presumed.	"[{""reference_id"": ""PMID:19955419"", ""source_assertion"": ""Recombinant Mct reversibly converts mesaconyl-C1-CoA to mesaconyl-C4-CoA; NMR distinguishes the positional CoA isomers. Gel filtration supports a homodimer."", ""source_locator"": ""Results sec3–sec4""}, {""reference_id"": ""UniProtKB:A9WC36"", ""source_assertion"": ""The current reviewed entry assigns this exact reaction family with experimental evidence; the primary functional reference identifies OK-70-fl while the genome-sequence reference identifies J-10-fl."", ""source_locator"": ""/comments/0/texts; /comments/1/reaction; /references/0; /references/1""}, {""reference_id"": ""PMID:36535006"", ""source_assertion"": ""The later study explicitly names A9WC36, reuses pMCTCa_JZ05 and demonstrates the intramolecular isomerase mechanism in an intertwined homodimer. Slow intermolecular side reactions do not redefine the pathway reaction."", ""source_locator"": ""Accession Codes (notes-3); Materials and Methods sec2.2; Results sec3.1–sec3.3""}]"	"[{""id"": ""PMID:19955419"", ""source_sha256"": ""ef7bbdc7b8ebc8cd62ae4d586fe953a767fdce2865900f742e43336381fde7b1"", ""source_version"": ""Complete original primary full-text body retrieved 2026-10-11; strain and construct limits retained"", ""title"": ""Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2795484/""}, {""id"": ""PMID:36535006"", ""source_sha256"": ""1e2b5cd6f7c7b75defee99eeab9df22c73895bb3d34d9368ed46aace179e1769"", ""source_version"": ""Complete original primary full-text body retrieved 2026-10-11; strain and construct limits retained"", ""title"": ""Structural Basis for a Cork-Up Mechanism of the Intra-Molecular\nMesaconyl-CoA Transferase"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC9813914/""}, {""id"": ""UniProtKB:A9WC36"", ""source_sha256"": ""1b118f97cfe5eda9d99affa2f784981c22804242f1964c6723c031aa7a145724"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 79, sequence version 1, annotation date 2026-06-10"", ""title"": ""2-methylfumaryl-CoA isomerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9WC36.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-083_5ad6da087d5f	MetaCyc:CPLX-8466	BFO:0000051	UniProtKB:A9WC36	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8466|MetaCyc:MONOMER-17293|UniProtKB:A9WC36	Two copies of the native-mapped current component; the original biochemical construct and current genome strain remain explicitly distinguished.	"[{""reference_id"": ""MetaCyc:CPLX-8466"", ""source_assertion"": ""The native complex contains two copies of MONOMER-17293."", ""source_locator"": ""Protein[@frameid=\""CPLX-8466\""]/component""}, {""reference_id"": ""MetaCyc:MONOMER-17293"", ""source_assertion"": ""The native monomer cross-references UniProt A9WC36."", ""source_locator"": ""Protein[@frameid=\""MONOMER-17293\""]/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:A9WC36"", ""source_assertion"": ""The current subunit annotation is homodimer with experimental evidence."", ""source_locator"": ""/comments/4/texts""}]"	"[{""id"": ""MetaCyc:CPLX-8466"", ""source_sha256"": ""d26496e9b700768eca1cc9c8120d1d17357f7cae162ab2a5372de35c4f25e63e"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""mesaconyl-C1-CoA-C4-CoA transferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8466""}, {""id"": ""MetaCyc:MONOMER-17293"", ""source_sha256"": ""0c631e0d742ef651be03d00662d09a0678bc8357049f4721fec8d07213cf5e6d"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""mesaconyl-C1-CoA-C4-CoA transferase monomer"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-17293""}, {""id"": ""UniProtKB:A9WC36"", ""source_sha256"": ""1b118f97cfe5eda9d99affa2f784981c22804242f1964c6723c031aa7a145724"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 79, sequence version 1, annotation date 2026-06-10"", ""title"": ""2-methylfumaryl-CoA isomerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9WC36.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-084_7eb88fcb5263	MetaCyc:CPLX-8467	pathwaymech:catalyzes	RHEA:38273	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19955419|UniProtKB:A9WC41	Native species-level dimer with reviewed current component attribution. Original pathway experiments used OK-70-fl and J-10-fl-guided primers; exact clone/genome equivalence is not presumed.	"[{""reference_id"": ""PMID:19955419"", ""source_assertion"": ""Purified native and recombinant Meh hydrate mesaconyl-C4-CoA to S-citramalyl-CoA. The coupled sequence yields acetyl-CoA and pyruvate; gel filtration supports a homodimer."", ""source_locator"": ""Results sec5–sec6; Figure 4""}, {""reference_id"": ""UniProtKB:A9WC41"", ""source_assertion"": ""The current reviewed entry assigns this exact reaction family with experimental evidence; the primary functional reference identifies OK-70-fl while the genome-sequence reference identifies J-10-fl."", ""source_locator"": ""/comments/0/texts; /comments/1/reaction; /references/0; /references/1""}]"	"[{""id"": ""PMID:19955419"", ""source_sha256"": ""ef7bbdc7b8ebc8cd62ae4d586fe953a767fdce2865900f742e43336381fde7b1"", ""source_version"": ""Complete original primary full-text body retrieved 2026-10-11; strain and construct limits retained"", ""title"": ""Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2795484/""}, {""id"": ""UniProtKB:A9WC41"", ""source_sha256"": ""a10278adb158b44175f4a553000ecece1c658150580ec6e5b9ea971f1e9d9bbb"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 67, sequence version 1, annotation date 2026-09-02"", ""title"": ""Mesaconyl-C(4)-CoA hydratase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9WC41.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-085_39b46f914891	MetaCyc:CPLX-8467	BFO:0000051	UniProtKB:A9WC41	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8467|MetaCyc:MONOMER-17294|UniProtKB:A9WC41	Two copies of the native-mapped current component; the original biochemical construct and current genome strain remain explicitly distinguished.	"[{""reference_id"": ""MetaCyc:CPLX-8467"", ""source_assertion"": ""The native complex contains two copies of MONOMER-17294."", ""source_locator"": ""Protein[@frameid=\""CPLX-8467\""]/component""}, {""reference_id"": ""MetaCyc:MONOMER-17294"", ""source_assertion"": ""The native monomer cross-references UniProt A9WC41."", ""source_locator"": ""Protein[@frameid=\""MONOMER-17294\""]/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:A9WC41"", ""source_assertion"": ""The current subunit annotation is homodimer with experimental evidence."", ""source_locator"": ""/comments/4/texts""}]"	"[{""id"": ""MetaCyc:CPLX-8467"", ""source_sha256"": ""21eda91b23b05ea381129dafc6ffe9827bd99f6fb7644b9aedda1f84ff1af3b2"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""mesaconyl-C4-CoA hydratase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8467""}, {""id"": ""MetaCyc:MONOMER-17294"", ""source_sha256"": ""54782f0364ab06467fbaf4d354478fdf3b050054446a6028d1cd54e0741ee43c"", ""source_version"": ""MetaCyc 22.5; complete original XML retrieved 2026-10-11"", ""title"": ""mesaconyl-C4-CoA hydratase monomer"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-17294""}, {""id"": ""UniProtKB:A9WC41"", ""source_sha256"": ""a10278adb158b44175f4a553000ecece1c658150580ec6e5b9ea971f1e9d9bbb"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 67, sequence version 1, annotation date 2026-09-02"", ""title"": ""Mesaconyl-C(4)-CoA hydratase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9WC41.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-086_f010ab669d1c	UniProtKB:A9W9X0	pathwaymech:has_cofactor	CHEBI:57586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:A9W9X0	The source evidence tier is preserved.	"[{""reference_id"": ""UniProtKB:A9W9X0"", ""source_assertion"": ""The current protein annotation assigns biotin as cofactor by ARBA; the catalytic graph separately retains the covalently attached carrier states. Evidence tier: ECO:0000256."", ""source_locator"": ""/comments/0/cofactors""}]"	"[{""id"": ""UniProtKB:A9W9X0"", ""source_sha256"": ""5784ed335a0e688a35a9a7ba765695e73b97a8c06ed75fd883a7b17505bb77e4"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 97, sequence version 1, annotation date 2026-09-02"", ""title"": ""biotin carboxylase"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9W9X0.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-087_bb262e26929a	UniProtKB:A9WBQ9	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:A9WBQ9	The source evidence tier is preserved.	"[{""reference_id"": ""UniProtKB:A9WBQ9"", ""source_assertion"": ""The current beta-chain annotation assigns one zinc per subunit by HAMAP; this is not a direct experimental J-10-fl metal-occupancy measurement. Evidence tier: ECO:0000255."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}]"	"[{""id"": ""UniProtKB:A9WBQ9"", ""source_sha256"": ""648805f6552d26a8fd62c5b84a8b7921d4a1c2d8302c9a15f50d64e7d1c1307a"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 87, sequence version 1, annotation date 2026-09-02"", ""title"": ""Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta"", ""url"": ""https://rest.uniprot.org/uniprotkb/A9WBQ9.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-088_95f20dadced2	MetaCyc:CPLX-7549	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:S5N020	Alternative divalent-metal support, not simultaneous obligatory binding of both ions.	"[{""reference_id"": ""UniProtKB:S5N020"", ""source_assertion"": ""The reviewed Mcl cofactor annotation includes magnesium, with experimental evidence and an explicit divalent-cation qualification."", ""source_locator"": ""/comments/4/cofactors; /comments/4/note""}]"	"[{""id"": ""UniProtKB:S5N020"", ""source_sha256"": ""ee8c48a604f28f3967d40526eb452abb51d770277fc49caf368aaa274c581e02"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 45, sequence version 1, annotation date 2026-06-10"", ""title"": ""Malyl-CoA/beta-methylmalyl-CoA/citramalyl-CoA lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/S5N020.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-089_c7e374f7035e	MetaCyc:CPLX-7549	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:S5N020	Alternative divalent-metal support, not simultaneous obligatory binding of both ions.	"[{""reference_id"": ""UniProtKB:S5N020"", ""source_assertion"": ""The reviewed Mcl cofactor annotation includes manganese, with experimental evidence and an explicit divalent-cation qualification."", ""source_locator"": ""/comments/4/cofactors; /comments/4/note""}]"	"[{""id"": ""UniProtKB:S5N020"", ""source_sha256"": ""ee8c48a604f28f3967d40526eb452abb51d770277fc49caf368aaa274c581e02"", ""source_version"": ""Complete original UniProt JSON retrieved 2026-10-11; entry version 45, sequence version 1, annotation date 2026-06-10"", ""title"": ""Malyl-CoA/beta-methylmalyl-CoA/citramalyl-CoA lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/S5N020.json""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-090_c7fcb372a0fe	UniProtKB:Q8VRG6	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11821399	PCS requires a divalent cation in the inspected assay; magnesium is the selected assay cofactor, not an inferred exact occupancy count.	"[{""reference_id"": ""PMID:11821399"", ""source_assertion"": ""PCS activity required Mg2+ and was stimulated by K+; the reduction uses NADPH rather than NADH."", ""source_locator"": ""Results: Reductive Conversion of 3-Hydroxypropionate by Cell Extracts; Catalytic Properties of Propionyl-CoA Synthase""}]"	"[{""id"": ""PMID:11821399"", ""source_version"": ""Primary full-text copy inspected through web rendering 2026-10-11; local publisher and author-copy downloads returned 403; no body digest or local full-text replay claimed"", ""title"": ""Propionyl-coenzyme A synthase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO2 fixation"", ""url"": ""https://doi.org/10.1074/jbc.M110802200""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-091_e4b0f971afe4	UniProtKB:Q8VRG6	pathwaymech:has_cofactor	CHEBI:29103	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11821399	Potassium-dependent PCS ligase activity in the inspected assay; partial Rb+, NH4+ and Cs+ substitution is retained as a condition, not a unique in-vivo occupancy assignment.	"[{""reference_id"": ""PMID:11821399"", ""source_assertion"": ""PCS activity depended on potassium, with half-maximal activity at 4 mM KCl; related monovalent cations could partly substitute. The authors attribute this dependence to the CoA-ligase step."", ""source_locator"": ""Results: Catalytic Properties of Propionyl-CoA Synthase""}]"	"[{""id"": ""PMID:11821399"", ""source_version"": ""Primary full-text copy inspected through web rendering 2026-10-11; local publisher and author-copy downloads returned 403; no body digest or local full-text replay claimed"", ""title"": ""Propionyl-coenzyme A synthase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO2 fixation"", ""url"": ""https://doi.org/10.1074/jbc.M110802200""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-092_409beeabcdc7	CHEBI:15429	pathwaymech:inhibits	MetaCyc:CPLX-8466	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19955419	Partial inactivation in the substrate-present assay; not a physiological regulatory mechanism.	"[{""reference_id"": ""PMID:19955419"", ""source_assertion"": ""Hydroxylamine left about 60% Mct activity under the tested inactivation conditions; borohydride had no observed effect."", ""source_locator"": ""Results sec4, final paragraph""}]"	"[{""id"": ""PMID:19955419"", ""source_sha256"": ""ef7bbdc7b8ebc8cd62ae4d586fe953a767fdce2865900f742e43336381fde7b1"", ""source_version"": ""Complete original primary full-text body retrieved 2026-10-11; strain and construct limits retained"", ""title"": ""Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2795484/""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-093_ac275f18d03c	CHEBI:75636	pathwaymech:inhibits	MetaCyc:CPLX-8467	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19955419	Substrate inhibition only above the measured concentration threshold; this does not contradict its consumption as substrate.	"[{""reference_id"": ""PMID:19955419"", ""source_assertion"": ""The recombinant Meh hydratase was inhibited by mesaconyl-C4-CoA concentrations above 0.3 mM."", ""source_locator"": ""Results sec5, paragraph following Figure 4""}]"	"[{""id"": ""PMID:19955419"", ""source_sha256"": ""ef7bbdc7b8ebc8cd62ae4d586fe953a767fdce2865900f742e43336381fde7b1"", ""source_version"": ""Complete original primary full-text body retrieved 2026-10-11; strain and construct limits retained"", ""title"": ""Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2795484/""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-094_9c14f928356f	RHEA:10750	RO:0002413	RHEA:13502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750|RHEA:13502	Material continuity through CHEBI:17544; this is a cycle, not evidence of obligatory channeling or irreversible kinetic order.	"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea directed reaction 10750 places CHEBI:17544 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10750 rh:products http://rdf.rhea-db.org/10748_L; http://rdf.rhea-db.org/10748_L rh:contains1 http://rdf.rhea-db.org/Participant_10748_compound_1123; http://rdf.rhea-db.org/Participant_10748_compound_1123 rh:compound http://rdf.rhea-db.org/Compound_1123; rh:accession""}, {""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea directed reaction 13502 places CHEBI:17544 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:substrates http://rdf.rhea-db.org/13501_L; http://rdf.rhea-db.org/13501_L rh:contains1 http://rdf.rhea-db.org/Participant_13501_compound_1123; http://rdf.rhea-db.org/Participant_13501_compound_1123 rh:compound http://rdf.rhea-db.org/Compound_1123; rh:accession""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""CO2 + H2O => hydrogencarbonate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-095_3b61db1ab838	RHEA:13502	RO:0002413	RHEA:54729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13502|RHEA:54729	Material continuity through RHEA-COMP:10506; this is a cycle, not evidence of obligatory channeling or irreversible kinetic order.	"[{""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea directed reaction 13502 places RHEA-COMP:10506 on its products side with coefficient 1. This is a whole generic protein-bearing carrier state, not an isolated lysine residue."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:products http://rdf.rhea-db.org/13501_R; http://rdf.rhea-db.org/13501_R rh:contains1 http://rdf.rhea-db.org/Participant_13501_compound_10506; http://rdf.rhea-db.org/Participant_13501_compound_10506 rh:compound http://rdf.rhea-db.org/Compound_10506; rh:accession""}, {""reference_id"": ""RHEA:54729"", ""source_assertion"": ""Rhea directed reaction 54729 places RHEA-COMP:10506 on its substrates side with coefficient 1. This is a whole generic protein-bearing carrier state, not an isolated lysine residue."", ""source_locator"": ""http://rdf.rhea-db.org/54729 rh:substrates http://rdf.rhea-db.org/54728_L; http://rdf.rhea-db.org/54728_L rh:contains1 http://rdf.rhea-db.org/Participant_54728_compound_10506; http://rdf.rhea-db.org/Participant_54728_compound_10506 rh:compound http://rdf.rhea-db.org/Compound_10506; rh:accession""}]"	"[{""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:54729"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA => N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-096_1998c0bdf6a5	RHEA:54729	RO:0002413	RHEA:13502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13502|RHEA:54729	Material continuity through RHEA-COMP:10505; this is a cycle, not evidence of obligatory channeling or irreversible kinetic order.	"[{""reference_id"": ""RHEA:54729"", ""source_assertion"": ""Rhea directed reaction 54729 places RHEA-COMP:10505 on its products side with coefficient 1. This is a whole generic protein-bearing carrier state, not an isolated lysine residue."", ""source_locator"": ""http://rdf.rhea-db.org/54729 rh:products http://rdf.rhea-db.org/54728_R; http://rdf.rhea-db.org/54728_R rh:contains1 http://rdf.rhea-db.org/Participant_54728_compound_10505; http://rdf.rhea-db.org/Participant_54728_compound_10505 rh:compound http://rdf.rhea-db.org/Compound_10505; rh:accession""}, {""reference_id"": ""RHEA:13502"", ""source_assertion"": ""Rhea directed reaction 13502 places RHEA-COMP:10505 on its substrates side with coefficient 1. This is a whole generic protein-bearing carrier state, not an isolated lysine residue."", ""source_locator"": ""http://rdf.rhea-db.org/13502 rh:substrates http://rdf.rhea-db.org/13501_L; http://rdf.rhea-db.org/13501_L rh:contains1 http://rdf.rhea-db.org/Participant_13501_compound_10505; http://rdf.rhea-db.org/Participant_13501_compound_10505 rh:compound http://rdf.rhea-db.org/Compound_10505; rh:accession""}]"	"[{""id"": ""RHEA:13502"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP => N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:54729"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA => N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-097_bb59c5ad304b	RHEA:54729	RO:0002413	RHEA:26448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448|RHEA:54729	Material continuity through CHEBI:57384; this is a cycle, not evidence of obligatory channeling or irreversible kinetic order.	"[{""reference_id"": ""RHEA:54729"", ""source_assertion"": ""Rhea directed reaction 54729 places CHEBI:57384 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/54729 rh:products http://rdf.rhea-db.org/54728_R; http://rdf.rhea-db.org/54728_R rh:contains1 http://rdf.rhea-db.org/Participant_54728_compound_5125; http://rdf.rhea-db.org/Participant_54728_compound_5125 rh:compound http://rdf.rhea-db.org/Compound_5125; rh:accession""}, {""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea directed reaction 26448 places CHEBI:57384 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448 rh:substrates http://rdf.rhea-db.org/26446_R; http://rdf.rhea-db.org/26446_R rh:contains1 http://rdf.rhea-db.org/Participant_26446_compound_5125; http://rdf.rhea-db.org/Participant_26446_compound_5125 rh:compound http://rdf.rhea-db.org/Compound_5125; rh:accession""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""malonyl-CoA + NADPH + H(+) => 3-oxopropanoate + NADP(+) + CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:54729"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA => N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-098_576ec83df6b3	RHEA:26448	RO:0002413	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440|RHEA:26448	Material continuity through CHEBI:33190; this is a cycle, not evidence of obligatory channeling or irreversible kinetic order.	"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea directed reaction 26448 places CHEBI:33190 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448 rh:products http://rdf.rhea-db.org/26446_L; http://rdf.rhea-db.org/26446_L rh:contains1 http://rdf.rhea-db.org/Participant_26446_compound_5274; http://rdf.rhea-db.org/Participant_26446_compound_5274 rh:compound http://rdf.rhea-db.org/Compound_5274; rh:accession""}, {""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea directed reaction 26440 places CHEBI:33190 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:substrates http://rdf.rhea-db.org/26438_R; http://rdf.rhea-db.org/26438_R rh:contains1 http://rdf.rhea-db.org/Participant_26438_compound_5274; http://rdf.rhea-db.org/Participant_26438_compound_5274 rh:compound http://rdf.rhea-db.org/Compound_5274; rh:accession""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""malonyl-CoA + NADPH + H(+) => 3-oxopropanoate + NADP(+) + CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-099_cec321da7259	RHEA:26440	RO:0002413	RHEA:26535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440|RHEA:26535	Material continuity through CHEBI:16510; this is a cycle, not evidence of obligatory channeling or irreversible kinetic order.	"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea directed reaction 26440 places CHEBI:16510 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:products http://rdf.rhea-db.org/26438_L; http://rdf.rhea-db.org/26438_L rh:contains1 http://rdf.rhea-db.org/Participant_26438_compound_3378; http://rdf.rhea-db.org/Participant_26438_compound_3378 rh:compound http://rdf.rhea-db.org/Compound_3378; rh:accession""}, {""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea directed reaction 26535 places CHEBI:16510 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535 rh:substrates http://rdf.rhea-db.org/26534_L; http://rdf.rhea-db.org/26534_L rh:contains1 http://rdf.rhea-db.org/Participant_26534_compound_3378; http://rdf.rhea-db.org/Participant_26534_compound_3378 rh:compound http://rdf.rhea-db.org/Compound_3378; rh:accession""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-100_cf031fa09925	RHEA:26535	RO:0002413	RHEA:26519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26519|RHEA:26535	Material continuity through CHEBI:58528; this is a cycle, not evidence of obligatory channeling or irreversible kinetic order.	"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea directed reaction 26535 places CHEBI:58528 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535 rh:products http://rdf.rhea-db.org/26534_R; http://rdf.rhea-db.org/26534_R rh:contains1 http://rdf.rhea-db.org/Participant_26534_compound_6030; http://rdf.rhea-db.org/Participant_26534_compound_6030 rh:compound http://rdf.rhea-db.org/Compound_6030; rh:accession""}, {""reference_id"": ""RHEA:26519"", ""source_assertion"": ""Rhea directed reaction 26519 places CHEBI:58528 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26519 rh:substrates http://rdf.rhea-db.org/26518_L; http://rdf.rhea-db.org/26518_L rh:contains1 http://rdf.rhea-db.org/Participant_26518_compound_6030; http://rdf.rhea-db.org/Participant_26518_compound_6030 rh:compound http://rdf.rhea-db.org/Compound_6030; rh:accession""}]"	"[{""id"": ""RHEA:26519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-hydroxypropanoyl-CoA => acryloyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-101_28cbf8656c79	RHEA:26519	RO:0002413	RHEA:26456	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456|RHEA:26519	Material continuity through CHEBI:57367; this is a cycle, not evidence of obligatory channeling or irreversible kinetic order.	"[{""reference_id"": ""RHEA:26519"", ""source_assertion"": ""Rhea directed reaction 26519 places CHEBI:57367 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26519 rh:products http://rdf.rhea-db.org/26518_R; http://rdf.rhea-db.org/26518_R rh:contains1 http://rdf.rhea-db.org/Participant_26518_compound_2006; http://rdf.rhea-db.org/Participant_26518_compound_2006 rh:compound http://rdf.rhea-db.org/Compound_2006; rh:accession""}, {""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea directed reaction 26456 places CHEBI:57367 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456 rh:substrates http://rdf.rhea-db.org/26454_R; http://rdf.rhea-db.org/26454_R rh:contains1 http://rdf.rhea-db.org/Participant_26454_compound_2006; http://rdf.rhea-db.org/Participant_26454_compound_2006 rh:compound http://rdf.rhea-db.org/Compound_2006; rh:accession""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""acryloyl-CoA + NADPH + H(+) => propanoyl-CoA + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-hydroxypropanoyl-CoA => acryloyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-102_25e40a4f0d9b	RHEA:26456	RO:0002413	RHEA:38261	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456|RHEA:38261	Material continuity through CHEBI:57392; this is a cycle, not evidence of obligatory channeling or irreversible kinetic order.	"[{""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea directed reaction 26456 places CHEBI:57392 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456 rh:products http://rdf.rhea-db.org/26454_L; http://rdf.rhea-db.org/26454_L rh:contains1 http://rdf.rhea-db.org/Participant_26454_compound_3421; http://rdf.rhea-db.org/Participant_26454_compound_3421 rh:compound http://rdf.rhea-db.org/Compound_3421; rh:accession""}, {""reference_id"": ""RHEA:38261"", ""source_assertion"": ""Rhea directed reaction 38261 places CHEBI:57392 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38261 rh:substrates http://rdf.rhea-db.org/38259_R; http://rdf.rhea-db.org/38259_R rh:contains1 http://rdf.rhea-db.org/Participant_38259_compound_3421; http://rdf.rhea-db.org/Participant_38259_compound_3421 rh:compound http://rdf.rhea-db.org/Compound_3421; rh:accession""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""acryloyl-CoA + NADPH + H(+) => propanoyl-CoA + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:38261"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""propanoyl-CoA + glyoxylate => (2R,3S)-beta-methylmalyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-103_2581a4fafd78	RHEA:38261	RO:0002413	RHEA:38264	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38261|RHEA:38264	Material continuity through CHEBI:75634; this is a cycle, not evidence of obligatory channeling or irreversible kinetic order.	"[{""reference_id"": ""RHEA:38261"", ""source_assertion"": ""Rhea directed reaction 38261 places CHEBI:75634 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38261 rh:products http://rdf.rhea-db.org/38259_L; http://rdf.rhea-db.org/38259_L rh:contains1 http://rdf.rhea-db.org/Participant_38259_compound_8545; http://rdf.rhea-db.org/Participant_38259_compound_8545 rh:compound http://rdf.rhea-db.org/Compound_8545; rh:accession""}, {""reference_id"": ""RHEA:38264"", ""source_assertion"": ""Rhea directed reaction 38264 places CHEBI:75634 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38264 rh:substrates http://rdf.rhea-db.org/38263_L; http://rdf.rhea-db.org/38263_L rh:contains1 http://rdf.rhea-db.org/Participant_38263_compound_8545; http://rdf.rhea-db.org/Participant_38263_compound_8545 rh:compound http://rdf.rhea-db.org/Compound_8545; rh:accession""}]"	"[{""id"": ""RHEA:38261"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""propanoyl-CoA + glyoxylate => (2R,3S)-beta-methylmalyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:38264"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""(2R,3S)-beta-methylmalyl-CoA => 2-methylfumaryl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-104_2e812ce990b2	RHEA:38264	RO:0002413	RHEA:38268	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38264|RHEA:38268	Material continuity through CHEBI:75635; this is a cycle, not evidence of obligatory channeling or irreversible kinetic order.	"[{""reference_id"": ""RHEA:38264"", ""source_assertion"": ""Rhea directed reaction 38264 places CHEBI:75635 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38264 rh:products http://rdf.rhea-db.org/38263_R; http://rdf.rhea-db.org/38263_R rh:contains1 http://rdf.rhea-db.org/Participant_38263_compound_8546; http://rdf.rhea-db.org/Participant_38263_compound_8546 rh:compound http://rdf.rhea-db.org/Compound_8546; rh:accession""}, {""reference_id"": ""RHEA:38268"", ""source_assertion"": ""Rhea directed reaction 38268 places CHEBI:75635 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38268 rh:substrates http://rdf.rhea-db.org/38267_L; http://rdf.rhea-db.org/38267_L rh:contains1 http://rdf.rhea-db.org/Participant_38267_compound_8546; http://rdf.rhea-db.org/Participant_38267_compound_8546 rh:compound http://rdf.rhea-db.org/Compound_8546; rh:accession""}]"	"[{""id"": ""RHEA:38264"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""(2R,3S)-beta-methylmalyl-CoA => 2-methylfumaryl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:38268"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""2-methylfumaryl-CoA => 3-methylfumaryl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-105_586e621ab5fd	RHEA:38268	RO:0002413	RHEA:38273	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:38268|RHEA:38273	Material continuity through CHEBI:75636; this is a cycle, not evidence of obligatory channeling or irreversible kinetic order.	"[{""reference_id"": ""RHEA:38268"", ""source_assertion"": ""Rhea directed reaction 38268 places CHEBI:75636 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38268 rh:products http://rdf.rhea-db.org/38267_R; http://rdf.rhea-db.org/38267_R rh:contains1 http://rdf.rhea-db.org/Participant_38267_compound_8547; http://rdf.rhea-db.org/Participant_38267_compound_8547 rh:compound http://rdf.rhea-db.org/Compound_8547; rh:accession""}, {""reference_id"": ""RHEA:38273"", ""source_assertion"": ""Rhea directed reaction 38273 places CHEBI:75636 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38273 rh:substrates http://rdf.rhea-db.org/38271_R; http://rdf.rhea-db.org/38271_R rh:contains1 http://rdf.rhea-db.org/Participant_38271_compound_8547; http://rdf.rhea-db.org/Participant_38271_compound_8547 rh:compound http://rdf.rhea-db.org/Compound_8547; rh:accession""}]"	"[{""id"": ""RHEA:38268"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""2-methylfumaryl-CoA => 3-methylfumaryl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:38273"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-methylfumaryl-CoA + H2O => (3S)-citramalyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-106_5579c055735b	RHEA:38273	RO:0002413	RHEA:22613	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22613|RHEA:38273	Material continuity through CHEBI:58668; this is a cycle, not evidence of obligatory channeling or irreversible kinetic order.	"[{""reference_id"": ""RHEA:38273"", ""source_assertion"": ""Rhea directed reaction 38273 places CHEBI:58668 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/38273 rh:products http://rdf.rhea-db.org/38271_L; http://rdf.rhea-db.org/38271_L rh:contains1 http://rdf.rhea-db.org/Participant_38271_compound_2663; http://rdf.rhea-db.org/Participant_38271_compound_2663 rh:compound http://rdf.rhea-db.org/Compound_2663; rh:accession""}, {""reference_id"": ""RHEA:22613"", ""source_assertion"": ""Rhea directed reaction 22613 places CHEBI:58668 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22613 rh:substrates http://rdf.rhea-db.org/22612_L; http://rdf.rhea-db.org/22612_L rh:contains1 http://rdf.rhea-db.org/Participant_22612_compound_2663; http://rdf.rhea-db.org/Participant_22612_compound_2663 rh:compound http://rdf.rhea-db.org/Compound_2663; rh:accession""}]"	"[{""id"": ""RHEA:22613"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""(3S)-citramalyl-CoA => pyruvate + acetyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:38273"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""3-methylfumaryl-CoA + H2O => (3S)-citramalyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5744_glyox-edge-107_395129ed78e1	RHEA:22613	RO:0002413	RHEA:54729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22613|RHEA:54729	Material continuity through CHEBI:57288; this is a cycle, not evidence of obligatory channeling or irreversible kinetic order.	"[{""reference_id"": ""RHEA:22613"", ""source_assertion"": ""Rhea directed reaction 22613 places CHEBI:57288 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22613 rh:products http://rdf.rhea-db.org/22612_R; http://rdf.rhea-db.org/22612_R rh:contains1 http://rdf.rhea-db.org/Participant_22612_compound_4271; http://rdf.rhea-db.org/Participant_22612_compound_4271 rh:compound http://rdf.rhea-db.org/Compound_4271; rh:accession""}, {""reference_id"": ""RHEA:54729"", ""source_assertion"": ""Rhea directed reaction 54729 places CHEBI:57288 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/54729 rh:substrates http://rdf.rhea-db.org/54728_L; http://rdf.rhea-db.org/54728_L rh:contains1 http://rdf.rhea-db.org/Participant_54728_compound_4271; http://rdf.rhea-db.org/Participant_54728_compound_4271 rh:compound http://rdf.rhea-db.org/Compound_4271; rh:accession""}]"	"[{""id"": ""RHEA:22613"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""(3S)-citramalyl-CoA => pyruvate + acetyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:54729"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; digest covers complete compressed original RDF"", ""title"": ""N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA => N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-001_e0a10fca7670	CHEBI:15562	pathwaymech:consumes	RHEA:13246	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13246		"[{""reference_id"": ""RHEA:13246"", ""source_assertion"": ""Rhea lists CHEBI:15562 on the substrates side of RHEA:13246 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13246']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13246"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right isocitrate lyase direction"", ""url"": ""https://www.rhea-db.org/rhea/13246""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-002_8730caad34cc	RHEA:13246	pathwaymech:produces	CHEBI:30031	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13246		"[{""reference_id"": ""RHEA:13246"", ""source_assertion"": ""Rhea lists CHEBI:30031 on the products side of RHEA:13246 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13246']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13246"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right isocitrate lyase direction"", ""url"": ""https://www.rhea-db.org/rhea/13246""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-003_c2dcc489674d	RHEA:13246	pathwaymech:produces	CHEBI:36655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13246		"[{""reference_id"": ""RHEA:13246"", ""source_assertion"": ""Rhea lists CHEBI:36655 on the products side of RHEA:13246 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13246']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13246"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right isocitrate lyase direction"", ""url"": ""https://www.rhea-db.org/rhea/13246""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-004_ed5398d768de	CHEBI:15377	pathwaymech:consumes	RHEA:18182	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18182		"[{""reference_id"": ""RHEA:18182"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:18182 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18182']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18182"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right malate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/18182""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-005_5e3bd2aee061	CHEBI:36655	pathwaymech:consumes	RHEA:18182	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18182		"[{""reference_id"": ""RHEA:18182"", ""source_assertion"": ""Rhea lists CHEBI:36655 on the substrates side of RHEA:18182 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18182']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18182"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right malate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/18182""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-006_eef893b63812	CHEBI:57288	pathwaymech:consumes	RHEA:18182	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18182		"[{""reference_id"": ""RHEA:18182"", ""source_assertion"": ""Rhea lists CHEBI:57288 on the substrates side of RHEA:18182 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18182']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18182"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right malate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/18182""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-007_d07a53944173	RHEA:18182	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18182		"[{""reference_id"": ""RHEA:18182"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:18182 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18182']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18182"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right malate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/18182""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-008_4ca7c277ce1e	RHEA:18182	pathwaymech:produces	CHEBI:15589	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18182		"[{""reference_id"": ""RHEA:18182"", ""source_assertion"": ""Rhea lists CHEBI:15589 on the products side of RHEA:18182 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18182']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18182"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right malate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/18182""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-009_491d36cd70e6	RHEA:18182	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18182		"[{""reference_id"": ""RHEA:18182"", ""source_assertion"": ""Rhea lists CHEBI:57287 on the products side of RHEA:18182 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18182']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18182"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right malate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/18182""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-010_910748dfcb8f	CHEBI:15377	pathwaymech:consumes	RHEA:16846	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16846		"[{""reference_id"": ""RHEA:16846"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:16846 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16846']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16846"", ""source_version"": ""139"", ""title"": ""RHEA:16846 authority record"", ""url"": ""https://www.rhea-db.org/rhea/16846""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-011_7afb7f013afc	CHEBI:16452	pathwaymech:consumes	RHEA:16846	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16846		"[{""reference_id"": ""RHEA:16846"", ""source_assertion"": ""Rhea lists CHEBI:16452 on the substrates side of RHEA:16846 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16846']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16846"", ""source_version"": ""139"", ""title"": ""RHEA:16846 authority record"", ""url"": ""https://www.rhea-db.org/rhea/16846""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-012_ac61233f770d	CHEBI:57288	pathwaymech:consumes	RHEA:16846	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16846		"[{""reference_id"": ""RHEA:16846"", ""source_assertion"": ""Rhea lists CHEBI:57288 on the substrates side of RHEA:16846 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16846']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16846"", ""source_version"": ""139"", ""title"": ""RHEA:16846 authority record"", ""url"": ""https://www.rhea-db.org/rhea/16846""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-013_bf0ba943ebfb	RHEA:16846	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16846		"[{""reference_id"": ""RHEA:16846"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:16846 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16846']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16846"", ""source_version"": ""139"", ""title"": ""RHEA:16846 authority record"", ""url"": ""https://www.rhea-db.org/rhea/16846""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-014_e3cd0d36130c	RHEA:16846	pathwaymech:produces	CHEBI:16947	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16846		"[{""reference_id"": ""RHEA:16846"", ""source_assertion"": ""Rhea lists CHEBI:16947 on the products side of RHEA:16846 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16846']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16846"", ""source_version"": ""139"", ""title"": ""RHEA:16846 authority record"", ""url"": ""https://www.rhea-db.org/rhea/16846""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-015_d49d97172cab	RHEA:16846	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16846		"[{""reference_id"": ""RHEA:16846"", ""source_assertion"": ""Rhea lists CHEBI:57287 on the products side of RHEA:16846 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16846']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16846"", ""source_version"": ""139"", ""title"": ""RHEA:16846 authority record"", ""url"": ""https://www.rhea-db.org/rhea/16846""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-016_829f9f67fb96	CHEBI:16947	pathwaymech:consumes	RHEA:10229	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10229		"[{""reference_id"": ""RHEA:10229"", ""source_assertion"": ""Rhea lists CHEBI:16947 on the substrates side of RHEA:10229 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10229']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10229"", ""source_version"": ""139"", ""title"": ""RHEA:10229 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10229""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-017_731223c54581	RHEA:10229	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10229		"[{""reference_id"": ""RHEA:10229"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:10229 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10229']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10229"", ""source_version"": ""139"", ""title"": ""RHEA:10229 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10229""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-018_d4d3684bf653	RHEA:10229	pathwaymech:produces	CHEBI:16383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10229		"[{""reference_id"": ""RHEA:10229"", ""source_assertion"": ""Rhea lists CHEBI:16383 on the products side of RHEA:10229 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10229']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10229"", ""source_version"": ""139"", ""title"": ""RHEA:10229 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10229""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-019_18ef2c6d0e46	CHEBI:15377	pathwaymech:consumes	RHEA:22145	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22145		"[{""reference_id"": ""RHEA:22145"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:22145 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22145']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22145"", ""source_version"": ""139"", ""title"": ""RHEA:22145 authority record"", ""url"": ""https://www.rhea-db.org/rhea/22145""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-020_ebf71b35a859	CHEBI:16383	pathwaymech:consumes	RHEA:22145	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22145		"[{""reference_id"": ""RHEA:22145"", ""source_assertion"": ""Rhea lists CHEBI:16383 on the substrates side of RHEA:22145 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22145']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22145"", ""source_version"": ""139"", ""title"": ""RHEA:22145 authority record"", ""url"": ""https://www.rhea-db.org/rhea/22145""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-021_75257ec6da8f	RHEA:22145	pathwaymech:produces	CHEBI:15562	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22145		"[{""reference_id"": ""RHEA:22145"", ""source_assertion"": ""Rhea lists CHEBI:15562 on the products side of RHEA:22145 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22145']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22145"", ""source_version"": ""139"", ""title"": ""RHEA:22145 authority record"", ""url"": ""https://www.rhea-db.org/rhea/22145""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-022_e1b0a8835518	CHEBI:15589	pathwaymech:consumes	RHEA:21433	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21433		"[{""reference_id"": ""RHEA:21433"", ""source_assertion"": ""Rhea lists CHEBI:15589 on the substrates side of RHEA:21433 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21433']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21433"", ""source_version"": ""139"", ""title"": ""RHEA:21433 authority record"", ""url"": ""https://www.rhea-db.org/rhea/21433""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-023_1a6670c200e8	CHEBI:57540	pathwaymech:consumes	RHEA:21433	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21433		"[{""reference_id"": ""RHEA:21433"", ""source_assertion"": ""Rhea lists CHEBI:57540 on the substrates side of RHEA:21433 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21433']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21433"", ""source_version"": ""139"", ""title"": ""RHEA:21433 authority record"", ""url"": ""https://www.rhea-db.org/rhea/21433""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-024_67957af2d1f3	RHEA:21433	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21433		"[{""reference_id"": ""RHEA:21433"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:21433 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21433']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21433"", ""source_version"": ""139"", ""title"": ""RHEA:21433 authority record"", ""url"": ""https://www.rhea-db.org/rhea/21433""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-025_ae7ade4f6b4b	RHEA:21433	pathwaymech:produces	CHEBI:16452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21433		"[{""reference_id"": ""RHEA:21433"", ""source_assertion"": ""Rhea lists CHEBI:16452 on the products side of RHEA:21433 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21433']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21433"", ""source_version"": ""139"", ""title"": ""RHEA:21433 authority record"", ""url"": ""https://www.rhea-db.org/rhea/21433""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-026_eef709a033fc	RHEA:21433	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21433		"[{""reference_id"": ""RHEA:21433"", ""source_assertion"": ""Rhea lists CHEBI:57945 on the products side of RHEA:21433 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21433']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21433"", ""source_version"": ""139"", ""title"": ""RHEA:21433 authority record"", ""url"": ""https://www.rhea-db.org/rhea/21433""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-027_e37e2bc6291f	EC:4.1.3.1	pathwaymech:catalyzes	RHEA:13246	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:10572116|RHEA:13245		"[{""reference_id"": ""RHEA:13245"", ""source_assertion"": ""Rhea associates EC:4.1.3.1 with the reaction family containing RHEA:13246."", ""source_locator"": ""rh:ec""}, {""quote"": ""In this study we express and purify Icl, as well as AceA proteins, and show that both exhibit isocitrate lyase activity."", ""reference_id"": ""PMID:10572116"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Honer Zu Bentrup et al., Journal of Bacteriology, 1999"", ""id"": ""PMID:10572116"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/10572116/""}, {""id"": ""RHEA:13245"", ""source_version"": ""139"", ""title"": ""Rhea isocitrate lyase reaction"", ""url"": ""https://www.rhea-db.org/rhea/13245""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-028_9920743d9a03	EC:2.3.3.9	pathwaymech:catalyzes	RHEA:18182	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12393860|RHEA:18181		"[{""reference_id"": ""RHEA:18181"", ""source_assertion"": ""Rhea associates EC:2.3.3.9 with the reaction family containing RHEA:18182."", ""source_locator"": ""rh:ec""}, {""quote"": ""The glcB gene from M. tuberculosis, which encodes malate synthase, was cloned, and GlcB was expressed in Escherichia coli."", ""reference_id"": ""PMID:12393860"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Smith et al., Journal of Biological Chemistry, 2003"", ""id"": ""PMID:12393860"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12393860/""}, {""id"": ""RHEA:18181"", ""source_version"": ""139"", ""title"": ""Rhea malate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/18181""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-029_8b0293d31e2f	EC:2.3.3.1	pathwaymech:catalyzes	RHEA:16846	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:16027371|RHEA:16845		"[{""reference_id"": ""RHEA:16845"", ""source_assertion"": ""Rhea associates EC:2.3.3.1 with the reaction family containing RHEA:16846."", ""source_locator"": ""rh:ec""}, {""reference_id"": ""PMID:16027371"", ""source_assertion"": ""The study measured citrate synthase, aconitase and malate dehydrogenase activities in Mycobacterium tuberculosis lysates."", ""source_locator"": ""PubMed Abstract; enzyme activity measurements""}]"	"[{""id"": ""PMID:16027371"", ""title"": ""PMID:16027371 authority record"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/16027371/""}, {""id"": ""RHEA:16845"", ""source_version"": ""139"", ""title"": ""RHEA:16845 authority record"", ""url"": ""https://www.rhea-db.org/rhea/16845""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-030_5e5163cdce04	EC:4.2.1.3	pathwaymech:catalyzes	RHEA:10229	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLYOXYLATE-BYPASS|PMID:16027371		"[{""reference_id"": ""MetaCyc:GLYOXYLATE-BYPASS"", ""source_assertion"": ""The native pathway assigns EC:4.2.1.3 activity to the enzymatic step represented by RHEA:10229; this is a component step when the EC definition is an overall reaction."", ""source_locator"": ""Pathway/reaction-layout; Reaction/enzymatic-reaction and component-reaction relationships""}, {""reference_id"": ""PMID:16027371"", ""source_assertion"": ""The study measured citrate synthase, aconitase and malate dehydrogenase activities in Mycobacterium tuberculosis lysates."", ""source_locator"": ""PubMed Abstract; enzyme activity measurements""}]"	"[{""id"": ""MetaCyc:GLYOXYLATE-BYPASS"", ""source_sha256"": ""148101b2a79e1a244d2e94fc3952bec51a24d6d745fac052a4a3d081bc7026e6"", ""source_version"": ""22.5"", ""title"": ""MetaCyc glyoxylate cycle pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLYOXYLATE-BYPASS&detail=full""}, {""id"": ""PMID:16027371"", ""title"": ""PMID:16027371 authority record"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/16027371/""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-031_881097106470	EC:4.2.1.3	pathwaymech:catalyzes	RHEA:22145	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLYOXYLATE-BYPASS|PMID:16027371		"[{""reference_id"": ""MetaCyc:GLYOXYLATE-BYPASS"", ""source_assertion"": ""The native pathway assigns EC:4.2.1.3 activity to the enzymatic step represented by RHEA:22145; this is a component step when the EC definition is an overall reaction."", ""source_locator"": ""Pathway/reaction-layout; Reaction/enzymatic-reaction and component-reaction relationships""}, {""reference_id"": ""PMID:16027371"", ""source_assertion"": ""The study measured citrate synthase, aconitase and malate dehydrogenase activities in Mycobacterium tuberculosis lysates."", ""source_locator"": ""PubMed Abstract; enzyme activity measurements""}]"	"[{""id"": ""MetaCyc:GLYOXYLATE-BYPASS"", ""source_sha256"": ""148101b2a79e1a244d2e94fc3952bec51a24d6d745fac052a4a3d081bc7026e6"", ""source_version"": ""22.5"", ""title"": ""MetaCyc glyoxylate cycle pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLYOXYLATE-BYPASS&detail=full""}, {""id"": ""PMID:16027371"", ""title"": ""PMID:16027371 authority record"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/16027371/""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-032_2ea44244ca48	EC:1.1.1.37	pathwaymech:catalyzes	RHEA:21433	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:16027371|RHEA:21432		"[{""reference_id"": ""RHEA:21432"", ""source_assertion"": ""Rhea associates EC:1.1.1.37 with the reaction family containing RHEA:21433."", ""source_locator"": ""rh:ec""}, {""reference_id"": ""PMID:16027371"", ""source_assertion"": ""The study measured citrate synthase, aconitase and malate dehydrogenase activities in Mycobacterium tuberculosis lysates."", ""source_locator"": ""PubMed Abstract; enzyme activity measurements""}]"	"[{""id"": ""PMID:16027371"", ""title"": ""PMID:16027371 authority record"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/16027371/""}, {""id"": ""RHEA:21432"", ""source_version"": ""139"", ""title"": ""RHEA:21432 authority record"", ""url"": ""https://www.rhea-db.org/rhea/21432""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-033_094955085abb	RHEA:10229	pathwaymech:precedes	RHEA:22145	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLYOXYLATE-BYPASS		"[{""reference_id"": ""MetaCyc:GLYOXYLATE-BYPASS"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:10229 before RHEA:22145 in this pathway. Shared intermediate: CHEBI:16383."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GLYOXYLATE-BYPASS"", ""source_sha256"": ""148101b2a79e1a244d2e94fc3952bec51a24d6d745fac052a4a3d081bc7026e6"", ""source_version"": ""22.5"", ""title"": ""MetaCyc glyoxylate cycle pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLYOXYLATE-BYPASS&detail=full""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-034_03ad6e5d0566	RHEA:13246	pathwaymech:precedes	RHEA:18182	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLYOXYLATE-BYPASS		"[{""reference_id"": ""MetaCyc:GLYOXYLATE-BYPASS"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:13246 before RHEA:18182 in this pathway. Shared intermediate: CHEBI:36655."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GLYOXYLATE-BYPASS"", ""source_sha256"": ""148101b2a79e1a244d2e94fc3952bec51a24d6d745fac052a4a3d081bc7026e6"", ""source_version"": ""22.5"", ""title"": ""MetaCyc glyoxylate cycle pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLYOXYLATE-BYPASS&detail=full""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-035_bbe31ef4b1d8	RHEA:16846	pathwaymech:precedes	RHEA:10229	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLYOXYLATE-BYPASS		"[{""reference_id"": ""MetaCyc:GLYOXYLATE-BYPASS"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:16846 before RHEA:10229 in this pathway. Shared intermediate: CHEBI:16947."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GLYOXYLATE-BYPASS"", ""source_sha256"": ""148101b2a79e1a244d2e94fc3952bec51a24d6d745fac052a4a3d081bc7026e6"", ""source_version"": ""22.5"", ""title"": ""MetaCyc glyoxylate cycle pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLYOXYLATE-BYPASS&detail=full""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-036_0915bcaaa48d	RHEA:18182	pathwaymech:precedes	RHEA:21433	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLYOXYLATE-BYPASS		"[{""reference_id"": ""MetaCyc:GLYOXYLATE-BYPASS"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:18182 before RHEA:21433 in this pathway. Shared intermediate: CHEBI:15589."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GLYOXYLATE-BYPASS"", ""source_sha256"": ""148101b2a79e1a244d2e94fc3952bec51a24d6d745fac052a4a3d081bc7026e6"", ""source_version"": ""22.5"", ""title"": ""MetaCyc glyoxylate cycle pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLYOXYLATE-BYPASS&detail=full""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-037_d5c791731054	RHEA:21433	pathwaymech:precedes	RHEA:16846	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLYOXYLATE-BYPASS		"[{""reference_id"": ""MetaCyc:GLYOXYLATE-BYPASS"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:21433 before RHEA:16846 in this pathway. Shared intermediate: CHEBI:16452."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GLYOXYLATE-BYPASS"", ""source_sha256"": ""148101b2a79e1a244d2e94fc3952bec51a24d6d745fac052a4a3d081bc7026e6"", ""source_version"": ""22.5"", ""title"": ""MetaCyc glyoxylate cycle pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLYOXYLATE-BYPASS&detail=full""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-038_b04b12b032ac	RHEA:22145	pathwaymech:precedes	RHEA:13246	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLYOXYLATE-BYPASS		"[{""reference_id"": ""MetaCyc:GLYOXYLATE-BYPASS"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:22145 before RHEA:13246 in this pathway. Shared intermediate: CHEBI:15562."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GLYOXYLATE-BYPASS"", ""source_sha256"": ""148101b2a79e1a244d2e94fc3952bec51a24d6d745fac052a4a3d081bc7026e6"", ""source_version"": ""22.5"", ""title"": ""MetaCyc glyoxylate cycle pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLYOXYLATE-BYPASS&detail=full""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-039_b62e57e262a8	UniProtKB:O07717	pathwaymech:enables	RHEA:13246	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:O07717		"[{""reference_id"": ""UniProtKB:O07717"", ""source_assertion"": ""UniProt annotates UniProtKB:O07717 with catalytic activity for the reaction family of RHEA:13246. Annotation evidence: ECO:0000250; organism taxon: NCBITaxon:83332."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:O07717"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:O07717 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/O07717.json""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-040_b65e855d8ba6	UniProtKB:O07717	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:O07717		"[{""reference_id"": ""UniProtKB:O07717"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:O07717 (evidence: ECO:0000250). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:O07717"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:O07717 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/O07717.json""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-041_6e7bbe8bd6c5	UniProtKB:O07718	pathwaymech:enables	RHEA:13246	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:O07718		"[{""reference_id"": ""UniProtKB:O07718"", ""source_assertion"": ""UniProt annotates UniProtKB:O07718 with catalytic activity for the reaction family of RHEA:13246. Annotation evidence: ECO:0000250; organism taxon: NCBITaxon:83332."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:O07718"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:O07718 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/O07718.json""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-042_a77f5338decb	UniProtKB:O07718	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:O07718		"[{""reference_id"": ""UniProtKB:O07718"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:O07718 (evidence: ECO:0000250). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:O07718"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:O07718 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/O07718.json""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-043_94dbe8df52f3	UniProtKB:P9WK13	pathwaymech:enables	RHEA:21433	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WK13		"[{""reference_id"": ""UniProtKB:P9WK13"", ""source_assertion"": ""UniProt annotates UniProtKB:P9WK13 with catalytic activity for the reaction family of RHEA:21433. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83332."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P9WK13"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P9WK13 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P9WK13.json""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-044_fe6e666c459f	UniProtKB:P9WK17	pathwaymech:enables	RHEA:18182	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WK17		"[{""reference_id"": ""UniProtKB:P9WK17"", ""source_assertion"": ""UniProt annotates UniProtKB:P9WK17 with catalytic activity for the reaction family of RHEA:18182. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83332."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P9WK17"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P9WK17 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P9WK17.json""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-045_7b2cf29d8018	CHEBI:15589	pathwaymech:inhibits	UniProtKB:P9WK17	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WK17		"[{""reference_id"": ""UniProtKB:P9WK17"", ""source_assertion"": ""UniProt activity-regulation annotation: By bromopyruvate, oxalate, and phosphoenolpyruvate. Malate inhibits the activity to 50% at 1 mM concentration. Glycolate inhibits only at fairly high concentrations"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P9WK17"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P9WK17 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P9WK17.json""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-046_68086fad6a11	UniProtKB:P9WK17	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WK17		"[{""reference_id"": ""UniProtKB:P9WK17"", ""source_assertion"": ""UniProt locates UniProtKB:P9WK17 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P9WK17"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P9WK17 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P9WK17.json""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-047_9cac71890d92	UniProtKB:P9WK17	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WK17		"[{""reference_id"": ""UniProtKB:P9WK17"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P9WK17 (evidence: ECO:0000255, ECO:0000269). Mg(2+). Mn(2+) is able to replace Mg(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P9WK17"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P9WK17 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P9WK17.json""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-048_f8737d799c12	UniProtKB:P9WK17	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WK17		"[{""reference_id"": ""UniProtKB:P9WK17"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P9WK17 (evidence: ECO:0000255, ECO:0000269). Mg(2+). Mn(2+) is able to replace Mg(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P9WK17"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P9WK17 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P9WK17.json""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-049_2576b5024518	UniProtKB:P9WKK7	pathwaymech:enables	RHEA:13246	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WKK7		"[{""reference_id"": ""UniProtKB:P9WKK7"", ""source_assertion"": ""UniProt annotates UniProtKB:P9WKK7 with catalytic activity for the reaction family of RHEA:13246. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83332."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P9WKK7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P9WKK7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P9WKK7.json""}]"	""
pathwaymech:MetaCyc_GLYOXYLATE-BYPASS_edge-050_00ca7fdd18b5	UniProtKB:P9WKK7	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WKK7		"[{""reference_id"": ""UniProtKB:P9WKK7"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P9WKK7 (evidence: ECO:0000269). Can also use Mn(2+) ion."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P9WKK7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P9WKK7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P9WKK7.json""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-001_74a556816cf8	CHEBI:16750	pathwaymech:consumes	RHEA:27711	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27711		"[{""reference_id"": ""RHEA:27711"", ""source_assertion"": ""RHEA:27711 explicitly lists CHEBI:16750 on its substrates side with coefficient 1; exact formula and charge follow the linked Rhea compound and ChEBI."", ""source_locator"": ""rhea.rdf.gz; rh:27711 rh:substrates <http://rdf.rhea-db.org/27710_L>; <http://rdf.rhea-db.org/27710_L> rh:contains1 <http://rdf.rhea-db.org/Participant_27710_compound_1817>; <http://rdf.rhea-db.org/Participant_27710_compound_1817> rh:compound <http://rdf.rhea-db.org/Compound_1817> / rh:chebi""}]"	"[{""id"": ""RHEA:27711"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""guanosine + ATP => GMP + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/27711""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-002_46c14326918f	CHEBI:30616	pathwaymech:consumes	RHEA:27711	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27711		"[{""reference_id"": ""RHEA:27711"", ""source_assertion"": ""RHEA:27711 explicitly lists CHEBI:30616 on its substrates side with coefficient 1; exact formula and charge follow the linked Rhea compound and ChEBI."", ""source_locator"": ""rhea.rdf.gz; rh:27711 rh:substrates <http://rdf.rhea-db.org/27710_L>; <http://rdf.rhea-db.org/27710_L> rh:contains1 <http://rdf.rhea-db.org/Participant_27710_compound_6372>; <http://rdf.rhea-db.org/Participant_27710_compound_6372> rh:compound <http://rdf.rhea-db.org/Compound_6372> / rh:chebi""}]"	"[{""id"": ""RHEA:27711"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""guanosine + ATP => GMP + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/27711""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-003_5178ac18a783	RHEA:27711	pathwaymech:produces	CHEBI:58115	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27711		"[{""reference_id"": ""RHEA:27711"", ""source_assertion"": ""RHEA:27711 explicitly lists CHEBI:58115 on its products side with coefficient 1; exact formula and charge follow the linked Rhea compound and ChEBI."", ""source_locator"": ""rhea.rdf.gz; rh:27711 rh:products <http://rdf.rhea-db.org/27710_R>; <http://rdf.rhea-db.org/27710_R> rh:contains1 <http://rdf.rhea-db.org/Participant_27710_compound_3807>; <http://rdf.rhea-db.org/Participant_27710_compound_3807> rh:compound <http://rdf.rhea-db.org/Compound_3807> / rh:chebi""}]"	"[{""id"": ""RHEA:27711"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""guanosine + ATP => GMP + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/27711""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-004_fb858ab6d0ac	RHEA:27711	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27711		"[{""reference_id"": ""RHEA:27711"", ""source_assertion"": ""RHEA:27711 explicitly lists CHEBI:456216 on its products side with coefficient 1; exact formula and charge follow the linked Rhea compound and ChEBI."", ""source_locator"": ""rhea.rdf.gz; rh:27711 rh:products <http://rdf.rhea-db.org/27710_R>; <http://rdf.rhea-db.org/27710_R> rh:contains1 <http://rdf.rhea-db.org/Participant_27710_compound_2710>; <http://rdf.rhea-db.org/Participant_27710_compound_2710> rh:compound <http://rdf.rhea-db.org/Compound_2710> / rh:chebi""}]"	"[{""id"": ""RHEA:27711"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""guanosine + ATP => GMP + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/27711""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-005_9e3be6adb20c	RHEA:27711	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27711		"[{""reference_id"": ""RHEA:27711"", ""source_assertion"": ""RHEA:27711 explicitly lists CHEBI:15378 on its products side with coefficient 1; exact formula and charge follow the linked Rhea compound and ChEBI."", ""source_locator"": ""rhea.rdf.gz; rh:27711 rh:products <http://rdf.rhea-db.org/27710_R>; <http://rdf.rhea-db.org/27710_R> rh:contains1 <http://rdf.rhea-db.org/Participant_27710_compound_3249>; <http://rdf.rhea-db.org/Participant_27710_compound_3249> rh:compound <http://rdf.rhea-db.org/Compound_3249> / rh:chebi""}]"	"[{""id"": ""RHEA:27711"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""guanosine + ATP => GMP + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/27711""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-006_4cb2a41aaceb	CHEBI:16750	pathwaymech:consumes	RHEA:13234	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13234		"[{""reference_id"": ""RHEA:13234"", ""source_assertion"": ""RHEA:13234 explicitly lists CHEBI:16750 on its substrates side with coefficient 1; exact formula and charge follow the linked Rhea compound and ChEBI."", ""source_locator"": ""rhea.rdf.gz; rh:13234 rh:substrates <http://rdf.rhea-db.org/13233_L>; <http://rdf.rhea-db.org/13233_L> rh:contains1 <http://rdf.rhea-db.org/Participant_13233_compound_1817>; <http://rdf.rhea-db.org/Participant_13233_compound_1817> rh:compound <http://rdf.rhea-db.org/Compound_1817> / rh:chebi""}]"	"[{""id"": ""RHEA:13234"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""guanosine + phosphate => alpha-D-ribose 1-phosphate + guanine"", ""url"": ""https://www.rhea-db.org/rhea/13234""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-007_7b088744fa3a	CHEBI:43474	pathwaymech:consumes	RHEA:13234	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13234		"[{""reference_id"": ""RHEA:13234"", ""source_assertion"": ""RHEA:13234 explicitly lists CHEBI:43474 on its substrates side with coefficient 1; exact formula and charge follow the linked Rhea compound and ChEBI."", ""source_locator"": ""rhea.rdf.gz; rh:13234 rh:substrates <http://rdf.rhea-db.org/13233_L>; <http://rdf.rhea-db.org/13233_L> rh:contains1 <http://rdf.rhea-db.org/Participant_13233_compound_5518>; <http://rdf.rhea-db.org/Participant_13233_compound_5518> rh:compound <http://rdf.rhea-db.org/Compound_5518> / rh:chebi""}]"	"[{""id"": ""RHEA:13234"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""guanosine + phosphate => alpha-D-ribose 1-phosphate + guanine"", ""url"": ""https://www.rhea-db.org/rhea/13234""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-008_f9ccf0ee8179	RHEA:13234	pathwaymech:produces	CHEBI:57720	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13234		"[{""reference_id"": ""RHEA:13234"", ""source_assertion"": ""RHEA:13234 explicitly lists CHEBI:57720 on its products side with coefficient 1; exact formula and charge follow the linked Rhea compound and ChEBI."", ""source_locator"": ""rhea.rdf.gz; rh:13234 rh:products <http://rdf.rhea-db.org/13233_R>; <http://rdf.rhea-db.org/13233_R> rh:contains1 <http://rdf.rhea-db.org/Participant_13233_compound_2276>; <http://rdf.rhea-db.org/Participant_13233_compound_2276> rh:compound <http://rdf.rhea-db.org/Compound_2276> / rh:chebi""}]"	"[{""id"": ""RHEA:13234"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""guanosine + phosphate => alpha-D-ribose 1-phosphate + guanine"", ""url"": ""https://www.rhea-db.org/rhea/13234""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-009_5ff9f34a7429	RHEA:13234	pathwaymech:produces	CHEBI:16235	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13234		"[{""reference_id"": ""RHEA:13234"", ""source_assertion"": ""RHEA:13234 explicitly lists CHEBI:16235 on its products side with coefficient 1; exact formula and charge follow the linked Rhea compound and ChEBI."", ""source_locator"": ""rhea.rdf.gz; rh:13234 rh:products <http://rdf.rhea-db.org/13233_R>; <http://rdf.rhea-db.org/13233_R> rh:contains1 <http://rdf.rhea-db.org/Participant_13233_compound_2523>; <http://rdf.rhea-db.org/Participant_13233_compound_2523> rh:compound <http://rdf.rhea-db.org/Compound_2523> / rh:chebi""}]"	"[{""id"": ""RHEA:13234"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""guanosine + phosphate => alpha-D-ribose 1-phosphate + guanine"", ""url"": ""https://www.rhea-db.org/rhea/13234""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-010_79f3438f5152	CHEBI:16235	pathwaymech:consumes	RHEA:25426	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25426		"[{""reference_id"": ""RHEA:25426"", ""source_assertion"": ""RHEA:25426 explicitly lists CHEBI:16235 on its substrates side with coefficient 1; exact formula and charge follow the linked Rhea compound and ChEBI."", ""source_locator"": ""rhea.rdf.gz; rh:25426 rh:substrates <http://rdf.rhea-db.org/25424_R>; <http://rdf.rhea-db.org/25424_R> rh:contains1 <http://rdf.rhea-db.org/Participant_25424_compound_2523>; <http://rdf.rhea-db.org/Participant_25424_compound_2523> rh:compound <http://rdf.rhea-db.org/Compound_2523> / rh:chebi""}]"	"[{""id"": ""RHEA:25426"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""guanine + 5-phospho-alpha-D-ribose 1-diphosphate => GMP + diphosphate"", ""url"": ""https://www.rhea-db.org/rhea/25426""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-011_8bceabdcc9e0	CHEBI:58017	pathwaymech:consumes	RHEA:25426	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25426		"[{""reference_id"": ""RHEA:25426"", ""source_assertion"": ""RHEA:25426 explicitly lists CHEBI:58017 on its substrates side with coefficient 1; exact formula and charge follow the linked Rhea compound and ChEBI."", ""source_locator"": ""rhea.rdf.gz; rh:25426 rh:substrates <http://rdf.rhea-db.org/25424_R>; <http://rdf.rhea-db.org/25424_R> rh:contains1 <http://rdf.rhea-db.org/Participant_25424_compound_4203>; <http://rdf.rhea-db.org/Participant_25424_compound_4203> rh:compound <http://rdf.rhea-db.org/Compound_4203> / rh:chebi""}]"	"[{""id"": ""RHEA:25426"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""guanine + 5-phospho-alpha-D-ribose 1-diphosphate => GMP + diphosphate"", ""url"": ""https://www.rhea-db.org/rhea/25426""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-012_1defc7e0b3a5	RHEA:25426	pathwaymech:produces	CHEBI:58115	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25426		"[{""reference_id"": ""RHEA:25426"", ""source_assertion"": ""RHEA:25426 explicitly lists CHEBI:58115 on its products side with coefficient 1; exact formula and charge follow the linked Rhea compound and ChEBI."", ""source_locator"": ""rhea.rdf.gz; rh:25426 rh:products <http://rdf.rhea-db.org/25424_L>; <http://rdf.rhea-db.org/25424_L> rh:contains1 <http://rdf.rhea-db.org/Participant_25424_compound_3807>; <http://rdf.rhea-db.org/Participant_25424_compound_3807> rh:compound <http://rdf.rhea-db.org/Compound_3807> / rh:chebi""}]"	"[{""id"": ""RHEA:25426"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""guanine + 5-phospho-alpha-D-ribose 1-diphosphate => GMP + diphosphate"", ""url"": ""https://www.rhea-db.org/rhea/25426""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-013_58820b883c2e	RHEA:25426	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25426		"[{""reference_id"": ""RHEA:25426"", ""source_assertion"": ""RHEA:25426 explicitly lists CHEBI:33019 on its products side with coefficient 1; exact formula and charge follow the linked Rhea compound and ChEBI."", ""source_locator"": ""rhea.rdf.gz; rh:25426 rh:products <http://rdf.rhea-db.org/25424_L>; <http://rdf.rhea-db.org/25424_L> rh:contains1 <http://rdf.rhea-db.org/Participant_25424_compound_2106>; <http://rdf.rhea-db.org/Participant_25424_compound_2106> rh:compound <http://rdf.rhea-db.org/Compound_2106> / rh:chebi""}]"	"[{""id"": ""RHEA:25426"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""guanine + 5-phospho-alpha-D-ribose 1-diphosphate => GMP + diphosphate"", ""url"": ""https://www.rhea-db.org/rhea/25426""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-014_7d259c9da035	RHEA:27711	BFO:0000050	MetaCyc:PWY-6579	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GUANOSINEKIN-RXN|MetaCyc:PWY-6579|MetaCyc:PWY-6618|RHEA:27711		"[{""reference_id"": ""MetaCyc:PWY-6579"", ""source_assertion"": ""PWY-6579 explicitly includes PWY-6618 as a constituent pathway. Its complete native constituent list is PWY-6618 and PWY-6620; the separately cited subpathway records supply their reaction membership."", ""source_locator"": ""PWY-6579.xml /ptools-xml/Pathway[@frameid=\""PWY-6579\""]/reaction-list/Pathway[@frameid=\""PWY-6618\""]""}, {""reference_id"": ""MetaCyc:PWY-6618"", ""source_assertion"": ""PWY-6618 explicitly contains GUANOSINEKIN-RXN in its reaction-list. This is explicit native pathway membership."", ""source_locator"": ""PWY-6618.xml /ptools-xml/Pathway/reaction-list/Reaction[@frameid=\""GUANOSINEKIN-RXN\""]""}, {""reference_id"": ""MetaCyc:GUANOSINEKIN-RXN"", ""source_assertion"": ""GUANOSINEKIN-RXN supplies explicit native chemical sides and links Rhea member 27711. Native orientation is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""GUANOSINEKIN-RXN.xml /ptools-xml/Reaction/(left|right|reaction-direction|dblink[dblink-db=\""RHEA\""])""}, {""reference_id"": ""RHEA:27711"", ""source_assertion"": ""Rhea master 27710 links directional member 27711; its left-to-right member has the complete selected substrate/product sides. Native and Rhea members are reconciled through this inspected family."", ""source_locator"": ""rhea.rdf.gz; rh:27710 rh:directionalReaction rh:27711; rh:27710 rh:bidirectionalReaction; rh:27711 rh:substrates/rh:products/rh:equation""}]"	"[{""id"": ""MetaCyc:GUANOSINEKIN-RXN"", ""source_sha256"": ""a25dca8bdec21481c03f50fdb08a26975061d8161f482a823dcfe72d212c5c3e"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""GUANOSINEKIN-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GUANOSINEKIN-RXN""}, {""id"": ""MetaCyc:PWY-6579"", ""source_sha256"": ""cc957b62f29a245019be216fd077181665fab624158aec2d55e58a0c1a453f08"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""superpathway of guanine and guanosine salvage"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6579""}, {""id"": ""MetaCyc:PWY-6618"", ""source_sha256"": ""2dd46e522911b582e3c4e85c96ee6b96b3e9cd1155c2ce8def65586c950dc8de"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""guanine and guanosine salvage III"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6618""}, {""id"": ""RHEA:27711"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""guanosine + ATP => GMP + ADP + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/27711""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-015_1a5d48814056	RHEA:13234	BFO:0000050	MetaCyc:PWY-6579	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6579|MetaCyc:PWY-6620|MetaCyc:RXN0-5199|RHEA:13234		"[{""reference_id"": ""MetaCyc:PWY-6579"", ""source_assertion"": ""PWY-6579 explicitly includes PWY-6620 as a constituent pathway. Its complete native constituent list is PWY-6618 and PWY-6620; the separately cited subpathway records supply their reaction membership."", ""source_locator"": ""PWY-6579.xml /ptools-xml/Pathway[@frameid=\""PWY-6579\""]/reaction-list/Pathway[@frameid=\""PWY-6620\""]""}, {""reference_id"": ""MetaCyc:PWY-6620"", ""source_assertion"": ""PWY-6620 explicitly contains RXN0-5199 in its reaction-list. This is explicit native pathway membership."", ""source_locator"": ""PWY-6620.xml /ptools-xml/Pathway/reaction-list/Reaction[@frameid=\""RXN0-5199\""]""}, {""reference_id"": ""MetaCyc:RXN0-5199"", ""source_assertion"": ""RXN0-5199 supplies explicit native chemical sides and links Rhea member 13236. Native orientation is REVERSIBLE."", ""source_locator"": ""RXN0-5199.xml /ptools-xml/Reaction/(left|right|reaction-direction|dblink[dblink-db=\""RHEA\""])""}, {""reference_id"": ""RHEA:13234"", ""source_assertion"": ""Rhea master 13233 links directional member 13234; its left-to-right member has the complete selected substrate/product sides. Native and Rhea members are reconciled through this inspected family."", ""source_locator"": ""rhea.rdf.gz; rh:13233 rh:directionalReaction rh:13234; rh:13233 rh:bidirectionalReaction; rh:13234 rh:substrates/rh:products/rh:equation""}]"	"[{""id"": ""MetaCyc:PWY-6579"", ""source_sha256"": ""cc957b62f29a245019be216fd077181665fab624158aec2d55e58a0c1a453f08"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""superpathway of guanine and guanosine salvage"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6579""}, {""id"": ""MetaCyc:PWY-6620"", ""source_sha256"": ""24bc00ae9624e1857880cd2b3f7e2fadfaeb237080444fdf0284a25e2b3765cf"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""guanine and guanosine salvage"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6620""}, {""id"": ""MetaCyc:RXN0-5199"", ""source_sha256"": ""56aafed7661c4bb22947e8d1c8d359d22ffff78b4904b8013f7c07092752d13c"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""RXN0-5199"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5199""}, {""id"": ""RHEA:13234"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""guanosine + phosphate => alpha-D-ribose 1-phosphate + guanine"", ""url"": ""https://www.rhea-db.org/rhea/13234""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-016_c7b98179a411	RHEA:25426	BFO:0000050	MetaCyc:PWY-6579	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GUANPRIBOSYLTRAN-RXN|MetaCyc:PWY-6579|MetaCyc:PWY-6620|RHEA:25426		"[{""reference_id"": ""MetaCyc:PWY-6579"", ""source_assertion"": ""PWY-6579 explicitly includes PWY-6620 as a constituent pathway. Its complete native constituent list is PWY-6618 and PWY-6620; the separately cited subpathway records supply their reaction membership."", ""source_locator"": ""PWY-6579.xml /ptools-xml/Pathway[@frameid=\""PWY-6579\""]/reaction-list/Pathway[@frameid=\""PWY-6620\""]""}, {""reference_id"": ""MetaCyc:PWY-6620"", ""source_assertion"": ""PWY-6620 explicitly contains GUANPRIBOSYLTRAN-RXN in its reaction-list. This is explicit native pathway membership."", ""source_locator"": ""PWY-6620.xml /ptools-xml/Pathway/reaction-list/Reaction[@frameid=\""GUANPRIBOSYLTRAN-RXN\""]""}, {""reference_id"": ""MetaCyc:GUANPRIBOSYLTRAN-RXN"", ""source_assertion"": ""GUANPRIBOSYLTRAN-RXN supplies explicit native chemical sides and links Rhea member 25427. Native orientation is PHYSIOL-RIGHT-TO-LEFT."", ""source_locator"": ""GUANPRIBOSYLTRAN-RXN.xml /ptools-xml/Reaction/(left|right|reaction-direction|dblink[dblink-db=\""RHEA\""])""}, {""reference_id"": ""RHEA:25426"", ""source_assertion"": ""Rhea master 25424 links directional member 25426; its right-to-left member has the complete selected substrate/product sides. Native and Rhea members are reconciled through this inspected family."", ""source_locator"": ""rhea.rdf.gz; rh:25424 rh:directionalReaction rh:25426; rh:25424 rh:bidirectionalReaction; rh:25426 rh:substrates/rh:products/rh:equation""}]"	"[{""id"": ""MetaCyc:GUANPRIBOSYLTRAN-RXN"", ""source_sha256"": ""90c87415e5ec261fcefaedf3495d2fddcf15a5f8ae6dd2be87d26c1bd0de41cc"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""GUANPRIBOSYLTRAN-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GUANPRIBOSYLTRAN-RXN""}, {""id"": ""MetaCyc:PWY-6579"", ""source_sha256"": ""cc957b62f29a245019be216fd077181665fab624158aec2d55e58a0c1a453f08"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""superpathway of guanine and guanosine salvage"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6579""}, {""id"": ""MetaCyc:PWY-6620"", ""source_sha256"": ""24bc00ae9624e1857880cd2b3f7e2fadfaeb237080444fdf0284a25e2b3765cf"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""guanine and guanosine salvage"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6620""}, {""id"": ""RHEA:25426"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""guanine + 5-phospho-alpha-D-ribose 1-diphosphate => GMP + diphosphate"", ""url"": ""https://www.rhea-db.org/rhea/25426""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-017_7f7655e9d62b	UniProtKB:P0AEW6	BFO:0000050	MetaCyc:CPLX0-322	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-322|PMID:32857952|UniProtKB:P0AEW6		"[{""reference_id"": ""MetaCyc:CPLX0-322"", ""source_assertion"": ""The native complex contains 2 copies of GSK-MONOMER. This preserves the native assembly membership; it does not make an individual subunit an independent catalyst."", ""source_locator"": ""CPLX0-322.xml /ptools-xml/Protein/component[Protein/@frameid=\""GSK-MONOMER\""]/(Protein|coefficient)""}, {""reference_id"": ""UniProtKB:P0AEW6"", ""source_assertion"": ""The reviewed P0AEW6 entry cross-references MetaCyc:GSK-MONOMER and annotates Homodimer. The assembly statement retains its cited experimental evidence."", ""source_locator"": ""uniprot-P0AEW6.json /uniProtKBCrossReferences[database=\""BioCyc\"",id=\""MetaCyc:GSK-MONOMER\""]; /comments/8""}, {""reference_id"": ""PMID:32857952"", ""source_assertion"": ""SEC-MALS found Gsk dimers without ppGpp and tetramers with ppGpp. GDP also promoted tetramerization less strongly; the dimer/tetramer distribution depends on ligand and protein concentration."", ""source_locator"": ""Results: ppGpp tightly binds to Gsk, inhibits its activity and induces tetramerization; Fig. 1D-E; Methods: SEC-MALS, DLS""}]"	"[{""id"": ""MetaCyc:CPLX0-322"", ""source_sha256"": ""5752daa595bf8fe466703c0aed615d7f78ab03897cfa2232e996cd6b1f4b163f"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""inosine/guanosine kinase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-322""}, {""id"": ""PMID:32857952"", ""source_sha256"": ""d56d5330f10f96ad3c28ecdd10d26c0a7d5a8bf22ec05bb26dae7ef0e95845db"", ""source_version"": ""Complete primary article HTML inspected; published 2020, PMC availability 2021; retrieved 2026-10-11"", ""title"": ""ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC8362273/?pdf=0""}, {""id"": ""UniProtKB:P0AEW6"", ""source_sha256"": ""b2f56a5134caa015884e5b6571e050c4b2e8f24e0e6b069bb20145a733d091a9"", ""source_version"": ""Reviewed entry version 135, sequence version 1; retrieved 2026-10-11"", ""title"": ""Guanosine-inosine kinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AEW6.json""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-018_800b780dc7c8	UniProtKB:P0ABP8	BFO:0000050	MetaCyc:DEOD-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOD-CPLX|PMID:235429|UniProtKB:P0ABP8		"[{""reference_id"": ""MetaCyc:DEOD-CPLX"", ""source_assertion"": ""The native complex contains 6 copies of DEOD-MONOMER. This preserves the native assembly membership; it does not make an individual subunit an independent catalyst."", ""source_locator"": ""DEOD-CPLX.xml /ptools-xml/Protein/component[Protein/@frameid=\""DEOD-MONOMER\""]/(Protein|coefficient)""}, {""reference_id"": ""UniProtKB:P0ABP8"", ""source_assertion"": ""The reviewed P0ABP8 entry cross-references MetaCyc:DEOD-MONOMER and annotates Homohexamer; trimer of homodimers. The assembly statement retains its cited experimental evidence."", ""source_locator"": ""uniprot-P0ABP8.json /uniProtKBCrossReferences[database=\""BioCyc\"",id=\""MetaCyc:DEOD-MONOMER\""]; /comments/10""}, {""reference_id"": ""PMID:235429"", ""source_assertion"": ""Purified E. coli and Salmonella enzymes had approximately six equal subunits; crosslinking supported the hexamer. Association experiments suggested that only the hexamer was active."", ""source_locator"": ""Europe PMC core batch /resultList/result[id=\""235429\""]/abstractText; abstract only""}]"	"[{""id"": ""MetaCyc:DEOD-CPLX"", ""source_sha256"": ""f362dcc29babaf5d23e730a329a7c436a0944d811a36ad1adb8ee8569e7962e5"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""purine nucleoside phosphorylase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOD-CPLX""}, {""id"": ""PMID:235429"", ""source_sha256"": ""2469ca988208d62a5b8ffe2a8f349d792c65b8814621ee2d223063b9feb429fe"", ""source_version"": ""Primary abstract inspected in Europe PMC core batch; digest covers full original batch JSON, not article full text"", ""title"": ""Purine nucleoside phosphorylase from Escherichia coli and Salmonella typhimurium. Purification and some properties."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/235429/""}, {""id"": ""UniProtKB:P0ABP8"", ""source_sha256"": ""261a1c1e34fcc0af42d3a3b4a16c27a01ecba13eee2437d3f4d8c51e422eed02"", ""source_version"": ""Reviewed entry version 149, sequence version 2; retrieved 2026-10-11"", ""title"": ""Purine nucleoside phosphorylase DeoD-type"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABP8.json""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-019_2b69883ff3e8	UniProtKB:P0A9M5	BFO:0000050	MetaCyc:GPT-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GPT-CPLX|PMID:9100006|UniProtKB:P0A9M5		"[{""reference_id"": ""MetaCyc:GPT-CPLX"", ""source_assertion"": ""The native complex contains 4 copies of GPT-MONOMER. This preserves the native assembly membership; it does not make an individual subunit an independent catalyst."", ""source_locator"": ""GPT-CPLX.xml /ptools-xml/Protein/component[Protein/@frameid=\""GPT-MONOMER\""]/(Protein|coefficient)""}, {""reference_id"": ""UniProtKB:P0A9M5"", ""source_assertion"": ""The reviewed P0A9M5 entry cross-references MetaCyc:GPT-MONOMER and annotates Homotetramer. The assembly statement retains its cited experimental evidence."", ""source_locator"": ""uniprot-P0A9M5.json /uniProtKBCrossReferences[database=\""BioCyc\"",id=\""MetaCyc:GPT-MONOMER\""]; /comments/9""}, {""reference_id"": ""PMID:9100006"", ""source_assertion"": ""The E. coli XPRT structure is a tetramer with 152 residues per subunit. The abstract directly reports this assembly and the phosphoribosyltransferase activity."", ""source_locator"": ""Europe PMC core batch /resultList/result[id=\""9100006\""]/abstractText; abstract only""}]"	"[{""id"": ""MetaCyc:GPT-CPLX"", ""source_sha256"": ""f8fd9a52dbf13332ba46fc2db946bc066871d2e3c5466280d3856b49c7a408e9"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""xanthine-guanine phosphoribosyltransferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GPT-CPLX""}, {""id"": ""PMID:9100006"", ""source_sha256"": ""2469ca988208d62a5b8ffe2a8f349d792c65b8814621ee2d223063b9feb429fe"", ""source_version"": ""Primary abstract inspected in Europe PMC core batch; digest covers full original batch JSON, not article full text"", ""title"": ""Crystal structure of Escherichia coli xanthine phosphoribosyltransferase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9100006/""}, {""id"": ""UniProtKB:P0A9M5"", ""source_sha256"": ""b0e83f13d146d4d5010d4e6c5762094d5fd99df854859c29444374513e64da01"", ""source_version"": ""Reviewed entry version 152, sequence version 1; retrieved 2026-10-11"", ""title"": ""Xanthine-guanine phosphoribosyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9M5.json""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-020_89dfe4225db1	MetaCyc:CPLX0-322	pathwaymech:catalyzes	RHEA:27711	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GUANOSINEKIN-ENZRXN|PMID:32857952|UniProtKB:P0AEW6		"[{""reference_id"": ""MetaCyc:GUANOSINEKIN-ENZRXN"", ""source_assertion"": ""GUANOSINEKIN-ENZRXN explicitly assigns enzyme CPLX0-322 to reaction GUANOSINEKIN-RXN. The chemical normalization is independently supported by reviewed UniProt and the Rhea reaction sides."", ""source_locator"": ""GUANOSINEKIN-ENZRXN.xml /ptools-xml/Enzymatic-Reaction/(enzyme/Protein|reaction/Reaction)""}, {""reference_id"": ""UniProtKB:P0AEW6"", ""source_assertion"": ""Reviewed catalytic activity supports guanosine phosphorylation and its forward physiological direction."", ""source_locator"": ""uniprot-P0AEW6.json /comments/1/reaction; /comments/1/physiologicalReactions""}, {""reference_id"": ""PMID:32857952"", ""source_assertion"": ""Gsk dimerization was required for kinase activity in the interface-mutant experiment. ppGpp-bound dimers remained more active than tetramers; this edge denotes the native dimer without asserting exclusive or constitutive oligomeric state."", ""source_locator"": ""Results: Gsk restructures both N- and C-termini to bind ppGpp, Fig. 2A and S2D-E; ppGpp inhibits Gsk by blocking conformational dynamics and inducing tetramerization, Fig. 3K""}]"	"[{""id"": ""MetaCyc:GUANOSINEKIN-ENZRXN"", ""source_sha256"": ""836b43df5a949351a736e501c160e9dfe7c0dd053fad0513f542909c7a3b641d"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""guanosine kinase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GUANOSINEKIN-ENZRXN""}, {""id"": ""PMID:32857952"", ""source_sha256"": ""d56d5330f10f96ad3c28ecdd10d26c0a7d5a8bf22ec05bb26dae7ef0e95845db"", ""source_version"": ""Complete primary article HTML inspected; published 2020, PMC availability 2021; retrieved 2026-10-11"", ""title"": ""ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC8362273/?pdf=0""}, {""id"": ""UniProtKB:P0AEW6"", ""source_sha256"": ""b2f56a5134caa015884e5b6571e050c4b2e8f24e0e6b069bb20145a733d091a9"", ""source_version"": ""Reviewed entry version 135, sequence version 1; retrieved 2026-10-11"", ""title"": ""Guanosine-inosine kinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AEW6.json""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-021_29a82b340c88	MetaCyc:DEOD-CPLX	pathwaymech:catalyzes	RHEA:13234	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GUANPHOSPHOR-ENZRXN|UniProtKB:P0ABP8		"[{""reference_id"": ""MetaCyc:GUANPHOSPHOR-ENZRXN"", ""source_assertion"": ""GUANPHOSPHOR-ENZRXN explicitly assigns enzyme DEOD-CPLX to reaction RXN0-5199. The chemical normalization is independently supported by reviewed UniProt and the Rhea reaction sides."", ""source_locator"": ""GUANPHOSPHOR-ENZRXN.xml /ptools-xml/Enzymatic-Reaction/(enzyme/Protein|reaction/Reaction)""}, {""reference_id"": ""UniProtKB:P0ABP8"", ""source_assertion"": ""Reviewed catalytic activity supports reversible guanosine phosphorolysis; the salvage pathway selects guanine-producing flux."", ""source_locator"": ""uniprot-P0ABP8.json /comments/5/reaction; /comments/0""}]"	"[{""id"": ""MetaCyc:GUANPHOSPHOR-ENZRXN"", ""source_sha256"": ""d0e66401a7d6c02f37c8531c4a33c030348565a8dd743bdb24f3c4b0e377cbfc"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""guanosine phosphorylase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GUANPHOSPHOR-ENZRXN""}, {""id"": ""UniProtKB:P0ABP8"", ""source_sha256"": ""261a1c1e34fcc0af42d3a3b4a16c27a01ecba13eee2437d3f4d8c51e422eed02"", ""source_version"": ""Reviewed entry version 149, sequence version 2; retrieved 2026-10-11"", ""title"": ""Purine nucleoside phosphorylase DeoD-type"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABP8.json""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-022_724c485bf10b	MetaCyc:GPT-CPLX	pathwaymech:catalyzes	RHEA:25426	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GUANPRIBOSYLTRAN-ENZRXN|PMID:9100006|UniProtKB:P0A9M5		"[{""reference_id"": ""MetaCyc:GUANPRIBOSYLTRAN-ENZRXN"", ""source_assertion"": ""GUANPRIBOSYLTRAN-ENZRXN explicitly assigns enzyme GPT-CPLX to reaction GUANPRIBOSYLTRAN-RXN. The chemical normalization is independently supported by reviewed UniProt and the Rhea reaction sides."", ""source_locator"": ""GUANPRIBOSYLTRAN-ENZRXN.xml /ptools-xml/Enzymatic-Reaction/(enzyme/Protein|reaction/Reaction)""}, {""reference_id"": ""UniProtKB:P0A9M5"", ""source_assertion"": ""Reviewed catalytic activity supports guanine phosphoribosyl transfer; the annotated physiological direction is right-to-left relative to the Rhea master."", ""source_locator"": ""uniprot-P0A9M5.json /comments/1/reaction; /comments/1/physiologicalReactions""}, {""reference_id"": ""PMID:9100006"", ""source_assertion"": ""The E. coli tetramer transfers the phosphoribosyl group from PRPP to guanine, xanthine or hypoxanthine, producing their mononucleotides; guanine-to-GMP is the reaction selected here."", ""source_locator"": ""Europe PMC core batch /resultList/result[id=\""9100006\""]/abstractText; abstract only""}]"	"[{""id"": ""MetaCyc:GUANPRIBOSYLTRAN-ENZRXN"", ""source_sha256"": ""42a5be5cf123bf3927b88153e62235bc07aa3014ee28478a99ed383ce8d93151"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""guanine phosphoribosyltransferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GUANPRIBOSYLTRAN-ENZRXN""}, {""id"": ""PMID:9100006"", ""source_sha256"": ""2469ca988208d62a5b8ffe2a8f349d792c65b8814621ee2d223063b9feb429fe"", ""source_version"": ""Primary abstract inspected in Europe PMC core batch; digest covers full original batch JSON, not article full text"", ""title"": ""Crystal structure of Escherichia coli xanthine phosphoribosyltransferase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9100006/""}, {""id"": ""UniProtKB:P0A9M5"", ""source_sha256"": ""b0e83f13d146d4d5010d4e6c5762094d5fd99df854859c29444374513e64da01"", ""source_version"": ""Reviewed entry version 152, sequence version 1; retrieved 2026-10-11"", ""title"": ""Xanthine-guanine phosphoribosyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9M5.json""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-023_7b4464560dcb	MetaCyc:CPLX0-322	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AEW6		"[{""reference_id"": ""UniProtKB:P0AEW6"", ""source_assertion"": ""Reviewed cofactor annotation assigns Mg2+ with experimental evidence. The additional free-Mg2+ requirement beyond Mg-ATP remains probable, as stated in the source."", ""source_locator"": ""uniprot-P0AEW6.json /comments/3/cofactors[cofactorCrossReference/id=\""CHEBI:18420\""]; /comments/3/note""}]"	"[{""id"": ""UniProtKB:P0AEW6"", ""source_sha256"": ""b2f56a5134caa015884e5b6571e050c4b2e8f24e0e6b069bb20145a733d091a9"", ""source_version"": ""Reviewed entry version 135, sequence version 1; retrieved 2026-10-11"", ""title"": ""Guanosine-inosine kinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AEW6.json""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-024_2008fdbd7c13	MetaCyc:GPT-CPLX	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9100006|UniProtKB:P0A9M5		"[{""reference_id"": ""UniProtKB:P0A9M5"", ""source_assertion"": ""Reviewed cofactor annotation assigns Mg2+ with experimental evidence from the E. coli structure study."", ""source_locator"": ""uniprot-P0A9M5.json /comments/4/cofactors[cofactorCrossReference/id=\""CHEBI:18420\""]""}, {""reference_id"": ""PMID:9100006"", ""source_assertion"": ""The E. coli structure contains magnesium at the PRPP-binding site, interacting with Asp89. This supports bound magnesium without assigning an unsupported per-complex occupancy."", ""source_locator"": ""Europe PMC core batch /resultList/result[id=\""9100006\""]/abstractText; abstract only""}]"	"[{""id"": ""PMID:9100006"", ""source_sha256"": ""2469ca988208d62a5b8ffe2a8f349d792c65b8814621ee2d223063b9feb429fe"", ""source_version"": ""Primary abstract inspected in Europe PMC core batch; digest covers full original batch JSON, not article full text"", ""title"": ""Crystal structure of Escherichia coli xanthine phosphoribosyltransferase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9100006/""}, {""id"": ""UniProtKB:P0A9M5"", ""source_sha256"": ""b0e83f13d146d4d5010d4e6c5762094d5fd99df854859c29444374513e64da01"", ""source_version"": ""Reviewed entry version 152, sequence version 1; retrieved 2026-10-11"", ""title"": ""Xanthine-guanine phosphoribosyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9M5.json""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-025_f4893a52465b	RHEA:13234	RO:0002413	RHEA:25426	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6620|RHEA:13234|RHEA:25426		"[{""reference_id"": ""MetaCyc:PWY-6620"", ""source_assertion"": ""PWY-6620 explicitly places GUANPRIBOSYLTRAN-RXN downstream of RXN0-5199. Native layouts connect the two reactions through guanine, supplying the phosphoribosyltransferase substrate."", ""source_locator"": ""PWY-6620.xml /ptools-xml/Pathway/reaction-ordering[Reaction/@frameid=\""GUANPRIBOSYLTRAN-RXN\""]/predecessor-reactions/Reaction[@frameid=\""RXN0-5199\""]; /reaction-layout""}, {""reference_id"": ""RHEA:13234"", ""source_assertion"": ""The selected phosphorylase reaction produces CHEBI:16235 (guanine)."", ""source_locator"": ""rhea.rdf.gz; rh:13234 rh:products rh:13233_R; rh:13233_R rh:contains rh:Participant_13233_compound_2523; rh:Compound_2523 rh:chebi""}, {""reference_id"": ""RHEA:25426"", ""source_assertion"": ""The selected phosphoribosyltransferase reaction consumes CHEBI:16235 (guanine). This explicit shared intermediate supports material transfer between these reactions."", ""source_locator"": ""rhea.rdf.gz; rh:25426 rh:substrates rh:25424_R; rh:25424_R rh:contains rh:Participant_25424_compound_2523; rh:Compound_2523 rh:chebi""}]"	"[{""id"": ""MetaCyc:PWY-6620"", ""source_sha256"": ""24bc00ae9624e1857880cd2b3f7e2fadfaeb237080444fdf0284a25e2b3765cf"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""guanine and guanosine salvage"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6620""}, {""id"": ""RHEA:13234"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""guanosine + phosphate => alpha-D-ribose 1-phosphate + guanine"", ""url"": ""https://www.rhea-db.org/rhea/13234""}, {""id"": ""RHEA:25426"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""guanine + 5-phospho-alpha-D-ribose 1-diphosphate => GMP + diphosphate"", ""url"": ""https://www.rhea-db.org/rhea/25426""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-026_b9bf40b73785	CHEBI:77828	pathwaymech:inhibits	UniProtKB:P0AEW6	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:32857952		"[{""reference_id"": ""PMID:32857952"", ""source_assertion"": ""Purified Gsk bound ppGpp and both guanosine- and inosine-kinase activities were inhibited in vitro. ppGpp blocks conformational dynamics and promotes a less-active tetramer; MG1655-derived mutant studies support physiological regulation."", ""source_locator"": ""Results: ppGpp tightly binds to Gsk, inhibits its activity and induces tetramerization, Fig. 1B-C and S1A; Methods: Construction of gsk(WT), ML3271 and gsk(K383A), ML3272""}]"	"[{""id"": ""PMID:32857952"", ""source_sha256"": ""d56d5330f10f96ad3c28ecdd10d26c0a7d5a8bf22ec05bb26dae7ef0e95845db"", ""source_version"": ""Complete primary article HTML inspected; published 2020, PMC availability 2021; retrieved 2026-10-11"", ""title"": ""ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC8362273/?pdf=0""}]"	""
pathwaymech:MetaCyc_PWY-6579_gua-edge-027_3895051fef5d	CHEBI:58189	pathwaymech:inhibits	UniProtKB:P0AEW6	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:10879466|PMID:32857952	The two inspected sources disagree about GTP inhibition. This graph asserts the supported GDP effect and leaves GTP inhibition unresolved; enzyme-level evidence is not a measured rate for every possible substrate.	"[{""reference_id"": ""PMID:10879466"", ""source_assertion"": ""The purified E. coli guanosine-inosine kinase was markedly inhibited by GDP. The abstract reports maximal activity at an ATP/Mg2+ concentration ratio of 0.5 and also reports GTP inhibition."", ""source_locator"": ""Europe PMC core batch /resultList/result[id=\""10879466\""]/abstractText; abstract only""}, {""reference_id"": ""PMID:32857952"", ""source_assertion"": ""GDP bound Gsk and inhibited the inosine-coupled assay less potently than ppGpp; GDP also promoted tetramerization. The Results introduction says GDP, but not GTP or GMP, provides feedback inhibition."", ""source_locator"": ""Results: ppGpp tightly binds to Gsk, inhibits its activity and induces tetramerization; Fig. 1B-C,E; Methods: ITC and DLS""}]"	"[{""id"": ""PMID:10879466"", ""source_sha256"": ""2469ca988208d62a5b8ffe2a8f349d792c65b8814621ee2d223063b9feb429fe"", ""source_version"": ""Primary abstract inspected in Europe PMC core batch; digest covers full original batch JSON, not article full text"", ""title"": ""End-product regulation and kinetic mechanism of guanosine-inosine kinase from Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/10879466/""}, {""id"": ""PMID:32857952"", ""source_sha256"": ""d56d5330f10f96ad3c28ecdd10d26c0a7d5a8bf22ec05bb26dae7ef0e95845db"", ""source_version"": ""Complete primary article HTML inspected; published 2020, PMC availability 2021; retrieved 2026-10-11"", ""title"": ""ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC8362273/?pdf=0""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-001_2c771422606f	gomodel:YeastPathways_PWY-7221/6a4c244800000662	RO:0002234	CHEBI:57464	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7221/6a4c244800000662 RO:0002234 gomodel:CHEBI_57464_IMP-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/0; endpoint types: /individuals/72/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-002_fe35f6f46c04	SGD:S000001550	pathwaymech:enables	gomodel:GDPKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GDPKIN-RXN RO:0002333 gomodel:YKL067W-MONOMER_GDPKIN-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/1; endpoint types: /individuals/20/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-003_45bffde72afe	gomodel:GUANYL-KIN-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GUANYL-KIN-RXN RO:0002234 gomodel:CHEBI_456216_GUANYL-KIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/2; endpoint types: /individuals/22/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-004_b832e38b9964	gomodel:GUANYL-KIN-RXN	BFO:0000050	GO:0106387	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GUANYL-KIN-RXN BFO:0000050 gomodel:YeastPathways_PWY-7221/YeastPathways_PWY-7221."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/3; endpoint types: /individuals/22/type; /individuals/63/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-005_07d2a93eaf5e	gomodel:YeastPathways_PWY-7221/6a4c244800000662	BFO:0000050	GO:0106387	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7221/6a4c244800000662 BFO:0000050 gomodel:YeastPathways_PWY-7221/YeastPathways_PWY-7221."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/4; endpoint types: /individuals/72/type; /individuals/63/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-006_67194052d714	gomodel:GUANYL-KIN-RXN	RO:0002234	CHEBI:58189	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GUANYL-KIN-RXN RO:0002234 gomodel:CHEBI_58189_GUANYL-KIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/5; endpoint types: /individuals/22/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-007_4d2c405ae321	gomodel:YeastPathways_PWY-7221/6a4c244800000662	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7221/6a4c244800000662 RO:0002234 gomodel:YeastPathways_PWY-7221/6a4c244800000667."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/6; endpoint types: /individuals/72/type; /individuals/77/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-008_0dda99a0f4d3	gomodel:YeastPathways_PWY-7221/6a4c244800000652	BFO:0000050	GO:0106387	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7221/6a4c244800000652 BFO:0000050 gomodel:YeastPathways_PWY-7221/YeastPathways_PWY-7221."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/7; endpoint types: /individuals/64/type; /individuals/63/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-009_8988ec31058a	gomodel:GUANYL-KIN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GUANYL-KIN-RXN RO:0002233 gomodel:CHEBI_30616_GUANYL-KIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/8; endpoint types: /individuals/22/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-010_cd53e14cb198	gomodel:IMP-DEHYDROG-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:IMP-DEHYDROG-RXN BFO:0000066 gomodel:reaction_IMP-DEHYDROG-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/9; endpoint types: /individuals/23/type; /individuals/62/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-011_88dcfec93ac9	gomodel:IMP-DEHYDROG-RXN	BFO:0000050	GO:0106387	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:IMP-DEHYDROG-RXN BFO:0000050 gomodel:YeastPathways_PWY-7221/YeastPathways_PWY-7221."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/10; endpoint types: /individuals/23/type; /individuals/63/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-012_3034ba16f2a1	gomodel:YeastPathways_PWY-7221/6a4c244800000652	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7221/6a4c244800000652 RO:0002233 gomodel:YeastPathways_PWY-7221/6a4c244800000655."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/11; endpoint types: /individuals/64/type; /individuals/67/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-013_54241d556dc2	gomodel:YeastPathways_PWY-7221/6a4c244800000652	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7221/6a4c244800000652 RO:0002233 gomodel:YeastPathways_PWY-7221/6a4c244800000654."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/12; endpoint types: /individuals/64/type; /individuals/66/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-014_c5bc8ccb5331	SGD:S000002862	pathwaymech:enables	gomodel:GUANYL-KIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GUANYL-KIN-RXN RO:0002333 gomodel:MONOMER3O-102_GUANYL-KIN-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/13; endpoint types: /individuals/22/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-015_c6418c91d4e4	gomodel:GMP-SYN-GLUT-RXN	RO:0002234	CHEBI:58115	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GMP-SYN-GLUT-RXN RO:0002234 gomodel:CHEBI_58115_GMP-SYN-GLUT-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/14; endpoint types: /individuals/21/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-016_b4cdd533b648	gomodel:IMP-DEHYDROG-RXN	RO:0002233	CHEBI:58053	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:IMP-DEHYDROG-RXN RO:0002233 gomodel:CHEBI_58053_IMP-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/15; endpoint types: /individuals/23/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-017_b57aa5302025	gomodel:GDPKIN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GDPKIN-RXN RO:0002233 gomodel:CHEBI_30616_GDPKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/16; endpoint types: /individuals/20/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-018_70320250b8fe	gomodel:GMP-SYN-GLUT-RXN	BFO:0000050	GO:0106387	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GMP-SYN-GLUT-RXN BFO:0000050 gomodel:YeastPathways_PWY-7221/YeastPathways_PWY-7221."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/17; endpoint types: /individuals/21/type; /individuals/63/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-019_4cd17cec57d9	gomodel:YeastPathways_PWY-7221/6a4c244800000662	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7221/6a4c244800000662 RO:0002233 gomodel:YeastPathways_PWY-7221/6a4c244800000664."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/18; endpoint types: /individuals/72/type; /individuals/74/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-020_06c36ee40210	gomodel:IMP-DEHYDROG-RXN	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:IMP-DEHYDROG-RXN RO:0002234 gomodel:CHEBI_57945_IMP-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/19; endpoint types: /individuals/23/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-021_edd8c70ee02c	gomodel:GUANYL-KIN-RXN	RO:0002233	CHEBI:58115	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GUANYL-KIN-RXN RO:0002233 gomodel:CHEBI_58115_GMP-SYN-GLUT-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/20; endpoint types: /individuals/22/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-022_00b4438145e5	gomodel:IMP-DEHYDROG-RXN	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:IMP-DEHYDROG-RXN RO:0002233 gomodel:CHEBI_57540_IMP-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/21; endpoint types: /individuals/23/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-023_fa5f231cd7d1	gomodel:GMP-SYN-GLUT-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GMP-SYN-GLUT-RXN RO:0002234 gomodel:CHEBI_29888_GMP-SYN-GLUT-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/22; endpoint types: /individuals/21/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-024_ea97f47cd48e	SGD:S000004830	pathwaymech:enables	gomodel:GMP-SYN-GLUT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GMP-SYN-GLUT-RXN RO:0002333 gomodel:YMR217W-MONOMER_GMP-SYN-GLUT-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/23; endpoint types: /individuals/21/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-025_ca3377c7e8cf	gomodel:YeastPathways_PWY-7221/6a4c244800000652	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7221/6a4c244800000652 RO:0002234 gomodel:YeastPathways_PWY-7221/6a4c244800000656."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/24; endpoint types: /individuals/64/type; /individuals/68/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-026_effd6eba0677	gomodel:YeastPathways_PWY-7221/6a4c244800000662	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7221/6a4c244800000662 BFO:0000066 gomodel:YeastPathways_PWY-7221/6a4c244800000671."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/25; endpoint types: /individuals/72/type; /individuals/79/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-027_28bd55b5e9ff	gomodel:GMP-SYN-GLUT-RXN	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GMP-SYN-GLUT-RXN RO:0002234 gomodel:CHEBI_456215_GMP-SYN-GLUT-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/26; endpoint types: /individuals/21/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-028_57efa4e70687	gomodel:GDPKIN-RXN	BFO:0000050	GO:0106387	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GDPKIN-RXN BFO:0000050 gomodel:YeastPathways_PWY-7221/YeastPathways_PWY-7221."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/27; endpoint types: /individuals/20/type; /individuals/63/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-029_e81dd00a1e81	gomodel:IMP-DEHYDROG-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:IMP-DEHYDROG-RXN RO:0002234 gomodel:CHEBI_15378_IMP-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/28; endpoint types: /individuals/23/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-030_5168767b3ff1	SGD:S000004424	pathwaymech:enables	gomodel:YeastPathways_PWY-7221/6a4c244800000662	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7221/6a4c244800000662 RO:0002333 gomodel:YeastPathways_PWY-7221/6a4c244800000670."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/29; endpoint types: /individuals/72/type; /individuals/78/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-031_2c5d6dfb4b55	gomodel:GMP-SYN-GLUT-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GMP-SYN-GLUT-RXN BFO:0000066 gomodel:reaction_GMP-SYN-GLUT-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/30; endpoint types: /individuals/21/type; /individuals/60/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-032_bfd37909f7e4	gomodel:GMP-SYN-GLUT-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GMP-SYN-GLUT-RXN RO:0002234 gomodel:CHEBI_15378_GMP-SYN-GLUT-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/31; endpoint types: /individuals/21/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-033_211cf8c53891	gomodel:GUANYL-KIN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GUANYL-KIN-RXN BFO:0000066 gomodel:reaction_GUANYL-KIN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/32; endpoint types: /individuals/22/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-034_923a80bcd83d	gomodel:YeastPathways_PWY-7221/6a4c244800000652	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7221/6a4c244800000652 BFO:0000066 gomodel:YeastPathways_PWY-7221/6a4c244800000661."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/33; endpoint types: /individuals/64/type; /individuals/71/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-035_cc86cad9b683	gomodel:GDPKIN-RXN	RO:0002233	CHEBI:58189	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GDPKIN-RXN RO:0002233 gomodel:CHEBI_58189_GUANYL-KIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/34; endpoint types: /individuals/20/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-036_1d7e3a8b1694	gomodel:GMP-SYN-GLUT-RXN	RO:0002233	CHEBI:58359	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GMP-SYN-GLUT-RXN RO:0002233 gomodel:CHEBI_58359_GMP-SYN-GLUT-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/35; endpoint types: /individuals/21/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-037_d5be195744fb	gomodel:IMP-DEHYDROG-RXN	RO:0002234	CHEBI:57464	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:IMP-DEHYDROG-RXN RO:0002234 gomodel:CHEBI_57464_IMP-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/36; endpoint types: /individuals/23/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-038_2123f0cb8e9d	gomodel:YeastPathways_PWY-7221/6a4c244800000662	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7221/6a4c244800000662 RO:0002234 gomodel:YeastPathways_PWY-7221/6a4c244800000666."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/37; endpoint types: /individuals/72/type; /individuals/76/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-039_24dab15f6564	SGD:S000004520	pathwaymech:enables	gomodel:YeastPathways_PWY-7221/6a4c244800000652	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7221/6a4c244800000652 RO:0002333 gomodel:YeastPathways_PWY-7221/6a4c244800000658."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/38; endpoint types: /individuals/64/type; /individuals/70/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-040_3837e4284f95	gomodel:GMP-SYN-GLUT-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GMP-SYN-GLUT-RXN RO:0002233 gomodel:CHEBI_30616_GMP-SYN-GLUT-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/39; endpoint types: /individuals/21/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-041_a9df3b6bb1a6	gomodel:IMP-DEHYDROG-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:IMP-DEHYDROG-RXN RO:0002233 gomodel:CHEBI_15377_IMP-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/40; endpoint types: /individuals/23/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-042_179ee8a23f6e	gomodel:GDPKIN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GDPKIN-RXN BFO:0000066 gomodel:reaction_GDPKIN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/41; endpoint types: /individuals/20/type; /individuals/59/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-043_31b80e92b4c5	gomodel:GDPKIN-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GDPKIN-RXN RO:0002234 gomodel:CHEBI_456216_GDPKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/42; endpoint types: /individuals/20/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-044_54926d5d8671	gomodel:GMP-SYN-GLUT-RXN	RO:0002233	CHEBI:57464	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GMP-SYN-GLUT-RXN RO:0002233 gomodel:CHEBI_57464_IMP-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/43; endpoint types: /individuals/21/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-045_21932d2e6a3d	gomodel:YeastPathways_PWY-7221/6a4c244800000662	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7221/6a4c244800000662 RO:0002233 gomodel:YeastPathways_PWY-7221/6a4c244800000665."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/44; endpoint types: /individuals/72/type; /individuals/75/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-046_93114cfb2753	gomodel:YeastPathways_PWY-7221/6a4c244800000662	RO:0002233	CHEBI:58053	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7221/6a4c244800000662 RO:0002233 gomodel:YeastPathways_PWY-7221/6a4c244800000663."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/45; endpoint types: /individuals/72/type; /individuals/73/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-047_e8240518d81c	SGD:S000001259	pathwaymech:enables	gomodel:IMP-DEHYDROG-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:IMP-DEHYDROG-RXN RO:0002333 gomodel:YHR216W-MONOMER_IMP-DEHYDROG-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/46; endpoint types: /individuals/23/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-048_74598affadb8	gomodel:GMP-SYN-GLUT-RXN	RO:0002234	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GMP-SYN-GLUT-RXN RO:0002234 gomodel:CHEBI_29985_GMP-SYN-GLUT-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/47; endpoint types: /individuals/21/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-049_baa20783cb07	gomodel:GDPKIN-RXN	RO:0002234	CHEBI:37565	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GDPKIN-RXN RO:0002234 gomodel:CHEBI_37565_GDPKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/48; endpoint types: /individuals/20/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-050_e459fe93f10d	gomodel:YeastPathways_PWY-7221/6a4c244800000652	RO:0002234	CHEBI:57464	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7221/6a4c244800000652 RO:0002234 gomodel:CHEBI_57464_IMP-DEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/49; endpoint types: /individuals/64/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-051_a71629768870	gomodel:GMP-SYN-GLUT-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:GMP-SYN-GLUT-RXN RO:0002233 gomodel:CHEBI_15377_GMP-SYN-GLUT-RXN."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/50; endpoint types: /individuals/21/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-052_4ed2635b2744	gomodel:YeastPathways_PWY-7221/6a4c244800000652	RO:0002233	CHEBI:58053	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7221/6a4c244800000652 RO:0002233 gomodel:YeastPathways_PWY-7221/6a4c244800000653."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/51; endpoint types: /individuals/64/type; /individuals/65/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_edge-053_37e8b0a91e70	gomodel:YeastPathways_PWY-7221/6a4c244800000652	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7221		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7221"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7221/6a4c244800000652 RO:0002234 gomodel:YeastPathways_PWY-7221/6a4c244800000657."", ""source_locator"": ""./YeastPathways_PWY-7221.json#/facts/52; endpoint types: /individuals/64/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7221"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY-7221.json"", ""title"": ""SGD GO-CAM guanosine ribonucleotides de novo biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_location-77bf27fc8523_6233b4a09de3	SGD:S000001550	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36010	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12472466) Source qualification: Localizes predominantly to the cytoplasm. A small fraction is present in the mitochondrial intermembrane space	"[{""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 has the exact SGD cross-reference SGD:S000001550."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P36010"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36010 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_location-551208086c3a_9810eb7ffbcc	SGD:S000001550	RO:0001025	GO:0005758	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36010	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12472466); ECO:0000269 (PubMed:16823961); ECO:0000269 (PubMed:22984289) Source qualification: Localizes predominantly to the cytoplasm. A small fraction is present in the mitochondrial intermembrane space	"[{""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 annotates location Mitochondrion intermembrane space (SL-0169)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 has the exact SGD cross-reference SGD:S000001550."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P36010"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36010 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_location-df39be83b379_07833c1b0743	SGD:S000004830	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38625	Physical protein location from reviewed UniProt. ECO:0000250 (UniProtKB:Q9P772)	"[{""reference_id"": ""UniProtKB:P38625"", ""source_assertion"": ""UniProtKB:P38625 annotates location Cytoplasm, cytosol (SL-0091)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3611/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38625"", ""source_assertion"": ""UniProtKB:P38625 has the exact SGD cross-reference SGD:S000004830."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3611/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38625"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38625 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_location-6c03e656f5d0_6014fbe2a4f0	SGD:S000004424	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P50095	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03156); ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P50095"", ""source_assertion"": ""UniProtKB:P50095 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2048/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P50095"", ""source_assertion"": ""UniProtKB:P50095 has the exact SGD cross-reference SGD:S000004424."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2048/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P50095"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P50095 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_location-663e17510a1b_4a4df34f218e	SGD:S000004520	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P50094	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03156); ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P50094"", ""source_assertion"": ""UniProtKB:P50094 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2047/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P50094"", ""source_assertion"": ""UniProtKB:P50094 has the exact SGD cross-reference SGD:S000004520."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2047/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P50094"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P50094 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_location-0a42dc183a3e_a321577d2f3a	SGD:S000001259	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38697	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03156); ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38697"", ""source_assertion"": ""UniProtKB:P38697 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1412/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38697"", ""source_assertion"": ""UniProtKB:P38697 has the exact SGD cross-reference SGD:S000001259."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1412/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38697"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38697 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_cofactor-857dafe2b77d_a3f513d77a5a	SGD:S000001550	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36010	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:5793714)	"[{""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1183/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 has the exact SGD cross-reference SGD:S000001550."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1183/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P36010"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36010 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_cofactor-23b908207ce8_9d6e4a424d9e	SGD:S000004830	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38625	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q4WFT3)	"[{""reference_id"": ""UniProtKB:P38625"", ""source_assertion"": ""UniProtKB:P38625 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3611/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P38625"", ""source_assertion"": ""UniProtKB:P38625 has the exact SGD cross-reference SGD:S000004830."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3611/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38625"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38625 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_cofactor-f318dd1ae1d1_2963501ea183	SGD:S000004424	pathwaymech:has_cofactor	CHEBI:29103	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P50095	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03156)	"[{""reference_id"": ""UniProtKB:P50095"", ""source_assertion"": ""UniProtKB:P50095 annotates CHEBI:29103 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2048/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P50095"", ""source_assertion"": ""UniProtKB:P50095 has the exact SGD cross-reference SGD:S000004424."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2048/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P50095"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P50095 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_cofactor-898e1afe12ee_d38fcb4f843e	SGD:S000004520	pathwaymech:has_cofactor	CHEBI:29103	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P50094	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03156)	"[{""reference_id"": ""UniProtKB:P50094"", ""source_assertion"": ""UniProtKB:P50094 annotates CHEBI:29103 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2047/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P50094"", ""source_assertion"": ""UniProtKB:P50094 has the exact SGD cross-reference SGD:S000004520."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2047/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P50094"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P50094 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7221_cofactor-098914609c12_0573cec55dd5	SGD:S000001259	pathwaymech:has_cofactor	CHEBI:29103	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38697	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03156)	"[{""reference_id"": ""UniProtKB:P38697"", ""source_assertion"": ""UniProtKB:P38697 annotates CHEBI:29103 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1412/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P38697"", ""source_assertion"": ""UniProtKB:P38697 has the exact SGD cross-reference SGD:S000001259."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1412/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38697"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38697 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-001_9cfb7e98b77d	gomodel:UROGENDECARBOX-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:UROGENDECARBOX-RXN BFO:0000066 gomodel:reaction_UROGENDECARBOX-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/0; endpoint types: /individuals/18/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-002_9b9f8d0f258e	gomodel:UROGENDECARBOX-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:UROGENDECARBOX-RXN RO:0002234 gomodel:CHEBI_16526_UROGENDECARBOX-RXN."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/1; endpoint types: /individuals/18/type; /individuals/8/type""}, {""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:UROGENDECARBOX-RXN RO:0002234 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/65692e7e00001653."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/39; endpoint types: /individuals/18/type; /individuals/57/type""}, {""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:UROGENDECARBOX-RXN RO:0002234 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/65692e7e00001651."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/40; endpoint types: /individuals/18/type; /individuals/55/type""}, {""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:UROGENDECARBOX-RXN RO:0002234 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/65692e7e00001649."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/44; endpoint types: /individuals/18/type; /individuals/53/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-003_d1020a53ff69	gomodel:PROTOHEMEFERROCHELAT-RXN	BFO:0000050	GO:0006783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOHEMEFERROCHELAT-RXN BFO:0000050 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/YeastPathways_HEME-BIOSYNTHESIS-II."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/2; endpoint types: /individuals/15/type; /individuals/46/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-004_9f9cf1d1ea12	gomodel:RXN0-1461	RO:0002233	CHEBI:57309	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:RXN0-1461 RO:0002233 gomodel:CHEBI_57309_UROGENDECARBOX-RXN."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/3; endpoint types: /individuals/17/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-005_1fe30116d58e	gomodel:RXN0-1461	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:RXN0-1461 RO:0002234 gomodel:CHEBI_15377_RXN0-1461."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/4; endpoint types: /individuals/17/type; /individuals/0/type""}, {""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:RXN0-1461 RO:0002234 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/65692e7e00001659."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/41; endpoint types: /individuals/17/type; /individuals/63/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-006_7c92d5ceecff	gomodel:RXN0-1461	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:RXN0-1461 RO:0002233 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/65692e7e00001655."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/5; endpoint types: /individuals/17/type; /individuals/59/type""}, {""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:RXN0-1461 RO:0002233 gomodel:CHEBI_15378_RXN0-1461."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/23; endpoint types: /individuals/17/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-007_f0930c36471e	SGD:S000002451	pathwaymech:enables	gomodel:RXN0-1461	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:RXN0-1461 RO:0002333 gomodel:YDR044W-MONOMER_RXN0-1461_controller."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/6; endpoint types: /individuals/17/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-008_4668f46a700c	gomodel:PROTOHEMEFERROCHELAT-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOHEMEFERROCHELAT-RXN RO:0002234 gomodel:CHEBI_15378_PROTOHEMEFERROCHELAT-RXN."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/7; endpoint types: /individuals/15/type; /individuals/1/type""}, {""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOHEMEFERROCHELAT-RXN RO:0002234 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/65692e7e00001686."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/30; endpoint types: /individuals/15/type; /individuals/77/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-009_9c5e5f35d1d4	gomodel:UROGENDECARBOX-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:UROGENDECARBOX-RXN RO:0002233 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/65692e7e00001647."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/8; endpoint types: /individuals/18/type; /individuals/51/type""}, {""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:UROGENDECARBOX-RXN RO:0002233 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/65692e7e00001643."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/27; endpoint types: /individuals/18/type; /individuals/47/type""}, {""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:UROGENDECARBOX-RXN RO:0002233 gomodel:CHEBI_15378_UROGENDECARBOX-RXN."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/34; endpoint types: /individuals/18/type; /individuals/3/type""}, {""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:UROGENDECARBOX-RXN RO:0002233 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/65692e7e00001645."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/36; endpoint types: /individuals/18/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-010_fe7a5cae2d76	gomodel:PROTOPORGENOXI-RXN	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOPORGENOXI-RXN RO:0002233 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/65692e7e00001661."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/9; endpoint types: /individuals/16/type; /individuals/65/type""}, {""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOPORGENOXI-RXN RO:0002233 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/65692e7e00001663."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/12; endpoint types: /individuals/16/type; /individuals/67/type""}, {""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOPORGENOXI-RXN RO:0002233 gomodel:CHEBI_15379_PROTOPORGENOXI-RXN."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/35; endpoint types: /individuals/16/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-011_e52f3e8e24dd	SGD:S000005702	pathwaymech:enables	gomodel:PROTOHEMEFERROCHELAT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOHEMEFERROCHELAT-RXN RO:0002333 gomodel:YOR176W-MONOMER_PROTOHEMEFERROCHELAT-RXN_controller."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/10; endpoint types: /individuals/15/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-012_e0bddfb34f01	gomodel:RXN0-1461	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:RXN0-1461 RO:0002234 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/65692e7e00001657."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/11; endpoint types: /individuals/17/type; /individuals/61/type""}, {""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:RXN0-1461 RO:0002234 gomodel:CHEBI_16526_RXN0-1461."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/26; endpoint types: /individuals/17/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-013_8d06bd448f1d	gomodel:PROTOPORGENOXI-RXN	RO:0002233	CHEBI:57307	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOPORGENOXI-RXN RO:0002233 gomodel:CHEBI_57307_RXN0-1461."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/13; endpoint types: /individuals/16/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-014_c3ed16b2f4ac	SGD:S000002454	pathwaymech:enables	gomodel:UROGENDECARBOX-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:UROGENDECARBOX-RXN RO:0002333 gomodel:YDR047W-MONOMER_UROGENDECARBOX-RXN_controller."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/14; endpoint types: /individuals/18/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-015_1d2c77d6b71e	gomodel:PROTOPORGENOXI-RXN	RO:0002234	CHEBI:57306	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOPORGENOXI-RXN RO:0002234 gomodel:CHEBI_57306_PROTOPORGENOXI-RXN."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/15; endpoint types: /individuals/16/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-016_a48e43704489	SGD:S000000816	pathwaymech:enables	gomodel:PROTOPORGENOXI-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOPORGENOXI-RXN RO:0002333 gomodel:YER014W-MONOMER_PROTOPORGENOXI-RXN_controller."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/16; endpoint types: /individuals/16/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-017_91abb1829f8b	gomodel:RXN0-1461	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:RXN0-1461 RO:0002233 gomodel:CHEBI_15379_RXN0-1461."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/17; endpoint types: /individuals/17/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-018_fdb8e93076c5	gomodel:PROTOPORGENOXI-RXN	RO:0002234	CHEBI:16240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOPORGENOXI-RXN RO:0002234 gomodel:CHEBI_16240_PROTOPORGENOXI-RXN."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/18; endpoint types: /individuals/16/type; /individuals/6/type""}, {""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOPORGENOXI-RXN RO:0002234 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/65692e7e00001665."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/19; endpoint types: /individuals/16/type; /individuals/69/type""}, {""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOPORGENOXI-RXN RO:0002234 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/65692e7e00001667."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/22; endpoint types: /individuals/16/type; /individuals/71/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-019_2f264a16b3c8	gomodel:PROTOPORGENOXI-RXN	BFO:0000050	GO:0006783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOPORGENOXI-RXN BFO:0000050 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/YeastPathways_HEME-BIOSYNTHESIS-II."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/20; endpoint types: /individuals/16/type; /individuals/46/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-020_0f29e5d3e51f	gomodel:PROTOHEMEFERROCHELAT-RXN	RO:0002234	CHEBI:17627	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOHEMEFERROCHELAT-RXN RO:0002234 gomodel:CHEBI_17627_PROTOHEMEFERROCHELAT-RXN."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/21; endpoint types: /individuals/15/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-021_6658c78b06a8	gomodel:UROGENDECARBOX-RXN	RO:0002234	CHEBI:57309	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:UROGENDECARBOX-RXN RO:0002234 gomodel:CHEBI_57309_UROGENDECARBOX-RXN."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/24; endpoint types: /individuals/18/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-022_f3669bf27e8e	gomodel:PROTOHEMEFERROCHELAT-RXN	BFO:0000066	GO:0005743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOHEMEFERROCHELAT-RXN BFO:0000066 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/65692e7e00001691."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/25; endpoint types: /individuals/15/type; /individuals/81/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-023_4436f71d6db6	gomodel:PROTOHEMEFERROCHELAT-RXN	RO:0002233	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOHEMEFERROCHELAT-RXN RO:0002233 gomodel:CHEBI_29033_PROTOHEMEFERROCHELAT-RXN."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/28; endpoint types: /individuals/15/type; /individuals/10/type""}, {""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOHEMEFERROCHELAT-RXN RO:0002233 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/65692e7e00001684."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/29; endpoint types: /individuals/15/type; /individuals/75/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-024_de693388eb43	gomodel:RXN0-1461	RO:0002234	CHEBI:57307	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:RXN0-1461 RO:0002234 gomodel:CHEBI_57307_RXN0-1461."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/31; endpoint types: /individuals/17/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-025_e4b5faa4784a	gomodel:RXN0-1461	BFO:0000050	GO:0006783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:RXN0-1461 BFO:0000050 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/YeastPathways_HEME-BIOSYNTHESIS-II."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/32; endpoint types: /individuals/17/type; /individuals/46/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-026_8524cbaa4729	gomodel:UROGENDECARBOX-RXN	RO:0002233	CHEBI:57308	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:UROGENDECARBOX-RXN RO:0002233 gomodel:CHEBI_57308_UROGENDECARBOX-RXN."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/33; endpoint types: /individuals/18/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-027_e01a76b33c64	gomodel:PROTOPORGENOXI-RXN	BFO:0000066	GO:0005743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOPORGENOXI-RXN BFO:0000066 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/65692e7e00001681."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/37; endpoint types: /individuals/16/type; /individuals/73/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-028_867dfef8c65c	gomodel:PROTOHEMEFERROCHELAT-RXN	RO:0002233	CHEBI:57306	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:PROTOHEMEFERROCHELAT-RXN RO:0002233 gomodel:CHEBI_57306_PROTOPORGENOXI-RXN."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/38; endpoint types: /individuals/15/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-029_d0e57fd6261a	gomodel:UROGENDECARBOX-RXN	BFO:0000050	GO:0006783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:UROGENDECARBOX-RXN BFO:0000050 gomodel:YeastPathways_HEME-BIOSYNTHESIS-II/YeastPathways_HEME-BIOSYNTHESIS-II."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/42; endpoint types: /individuals/18/type; /individuals/46/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_edge-030_7813a5b93a07	gomodel:RXN0-1461	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEME-BIOSYNTHESIS-II		"[{""reference_id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_assertion"": ""The model asserts gomodel:RXN0-1461 BFO:0000066 gomodel:reaction_RXN0-1461_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_HEME-BIOSYNTHESIS-II.json#/facts/43; endpoint types: /individuals/17/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEME-BIOSYNTHESIS-II"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-13; member ./YeastPathways_HEME-BIOSYNTHESIS-II.json"", ""title"": ""GO-CAM heme b biosynthesis I aerobic model YeastPathways_HEME-BIOSYNTHESIS-II"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_location-d58f8d91e9a6_37f3e8e99fff	SGD:S000002451	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P11353	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:3516695)	"[{""reference_id"": ""UniProtKB:P11353"", ""source_assertion"": ""UniProtKB:P11353 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/324/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P11353"", ""source_assertion"": ""UniProtKB:P11353 has the exact SGD cross-reference SGD:S000002451."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/324/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P11353"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P11353 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_location-4de9b56e0162_f05c7334d81c	SGD:S000005702	RO:0001025	GO:0005743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16622	Physical protein location from reviewed UniProt. evidence code not specified by source Topology: Peripheral membrane protein. Orientation: Matrix side. Source qualification: It is bound to the mitochondrial inner membrane in eukaryotic cells with its active site on the matrix side of the membrane	"[{""reference_id"": ""UniProtKB:P16622"", ""source_assertion"": ""UniProtKB:P16622 annotates location Mitochondrion inner membrane (SL-0168)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/445/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P16622"", ""source_assertion"": ""UniProtKB:P16622 has the exact SGD cross-reference SGD:S000005702."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/445/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P16622"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16622 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_location-4943ad3823a1_e95afa3f16c1	SGD:S000002454	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32347	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P32347"", ""source_assertion"": ""UniProtKB:P32347 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/881/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32347"", ""source_assertion"": ""UniProtKB:P32347 has the exact SGD cross-reference SGD:S000002454."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/881/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32347"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32347 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_location-de13db480f49_e34d201284ee	SGD:S000002454	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32347	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:2180703)	"[{""reference_id"": ""UniProtKB:P32347"", ""source_assertion"": ""UniProtKB:P32347 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/881/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32347"", ""source_assertion"": ""UniProtKB:P32347 has the exact SGD cross-reference SGD:S000002454."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/881/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32347"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32347 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_location-00353c58e961_8c22023c7f88	SGD:S000000816	RO:0001025	GO:0005743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40012	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:7798202) Source qualification: Bound to the mitochondrial inner membrane with its active site facing the cytosolic side	"[{""reference_id"": ""UniProtKB:P40012"", ""source_assertion"": ""UniProtKB:P40012 annotates location Mitochondrion inner membrane (SL-0168)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3703/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P40012"", ""source_assertion"": ""UniProtKB:P40012 has the exact SGD cross-reference SGD:S000000816."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3703/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40012"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40012 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HEME-BIOSYNTHESIS-II_cofactor-0aef0c961ff1_f8e39870bb1e	SGD:S000000816	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40012	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified Binds 1 FAD per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P32397)	"[{""reference_id"": ""UniProtKB:P40012"", ""source_assertion"": ""UniProtKB:P40012 annotates CHEBI:57692 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3703/comments/0/cofactors/0; /results/3703/comments/0/note""}, {""reference_id"": ""UniProtKB:P40012"", ""source_assertion"": ""UniProtKB:P40012 has the exact SGD cross-reference SGD:S000000816."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3703/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P40012"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40012 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-001_1e2f643982e1	gomodel:FARNESYLTRANSTRANSFERASE-RXN	RO:0002233	CHEBI:175763	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:FARNESYLTRANSTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_175763_FPPSYN-RXN."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/0; endpoint types: /individuals/16/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-002_9563158d444f	gomodel:RXN3O-9805	BFO:0000050	GO:0006744	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9805 BFO:0000050 gomodel:YeastPathways_HEXPPSYN-PWY-2/YeastPathways_HEXPPSYN-PWY-2."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/1; endpoint types: /individuals/20/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-003_482d7d14144b	gomodel:GPPSYN-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:GPPSYN-RXN RO:0002234 gomodel:CHEBI_29888_GPPSYN-RXN."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/2; endpoint types: /individuals/18/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-004_0d1ba1dd1740	gomodel:YeastPathways_HEXPPSYN-PWY-2/65692e7e00001766	pathwaymech:enables	gomodel:RXN-8813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN-8813 RO:0002333 gomodel:YeastPathways_HEXPPSYN-PWY-2/65692e7e00001766."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/3; endpoint types: /individuals/19/type; /individuals/59/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-005_819279ff681c	gomodel:GPPSYN-RXN	RO:0002233	CHEBI:128769	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:GPPSYN-RXN RO:0002233 gomodel:CHEBI_128769_GPPSYN-RXN."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/4; endpoint types: /individuals/18/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-006_a1c3b7d5beea	gomodel:GPPSYN-RXN	RO:0002233	CHEBI:57623	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:GPPSYN-RXN RO:0002233 gomodel:CHEBI_57623_GPPSYN-RXN."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/5; endpoint types: /individuals/18/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-007_229397b675e7	gomodel:GPPSYN-RXN	BFO:0000050	GO:0006744	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:GPPSYN-RXN BFO:0000050 gomodel:YeastPathways_HEXPPSYN-PWY-2/YeastPathways_HEXPPSYN-PWY-2."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/6; endpoint types: /individuals/18/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-008_16b54cf031e0	gomodel:RXN-8813	RO:0002234	CHEBI:57907	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN-8813 RO:0002234 gomodel:CHEBI_57907_RXN-8813."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/7; endpoint types: /individuals/19/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-009_6c83888848b3	gomodel:RXN-8813	RO:0002233	CHEBI:58756	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN-8813 RO:0002233 gomodel:CHEBI_58756_FARNESYLTRANSTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/8; endpoint types: /individuals/19/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-010_fb308ee6f1f3	gomodel:RXN-8813	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN-8813 BFO:0000066 gomodel:reaction_RXN-8813_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/9; endpoint types: /individuals/19/type; /individuals/53/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-011_6ec4853b66d7	gomodel:FARNESYLTRANSTRANSFERASE-RXN	RO:0002233	CHEBI:128769	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:FARNESYLTRANSTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_128769_FARNESYLTRANSTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/10; endpoint types: /individuals/16/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-012_170f6a1e530d	gomodel:GPPSYN-RXN	RO:0002413	gomodel:FPPSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:GPPSYN-RXN RO:0002413 gomodel:FPPSYN-RXN."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/11; endpoint types: /individuals/18/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-013_95787f1607f8	gomodel:FPPSYN-RXN	RO:0002234	CHEBI:175763	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:FPPSYN-RXN RO:0002234 gomodel:CHEBI_175763_FPPSYN-RXN."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/12; endpoint types: /individuals/17/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-014_3e55a115da67	SGD:S000003703	pathwaymech:enables	gomodel:FPPSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:FPPSYN-RXN RO:0002333 gomodel:YJL167W-MONOMER_FPPSYN-RXN_controller."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/13; endpoint types: /individuals/17/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-015_137c195e6971	gomodel:FARNESYLTRANSTRANSFERASE-RXN	BFO:0000050	GO:0006744	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:FARNESYLTRANSTRANSFERASE-RXN BFO:0000050 gomodel:YeastPathways_HEXPPSYN-PWY-2/YeastPathways_HEXPPSYN-PWY-2."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/14; endpoint types: /individuals/16/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-016_af0fb0444dcb	gomodel:FARNESYLTRANSTRANSFERASE-RXN	RO:0002234	CHEBI:58756	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:FARNESYLTRANSTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_58756_FARNESYLTRANSTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/15; endpoint types: /individuals/16/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-017_a241e0c96c92	gomodel:RXN-8813	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN-8813 RO:0002234 gomodel:CHEBI_29888_RXN-8813."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/16; endpoint types: /individuals/19/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-018_a1de3e3589e1	gomodel:RXN3O-9805	RO:0002233	CHEBI:128769	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9805 RO:0002233 gomodel:CHEBI_128769_RXN3O-9805."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/17; endpoint types: /individuals/20/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-019_7d1eec2cf69e	SGD:S000005990	pathwaymech:enables	gomodel:FARNESYLTRANSTRANSFERASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:FARNESYLTRANSTRANSFERASE-RXN RO:0002333 gomodel:YPL069C-MONOMER_FARNESYLTRANSTRANSFERASE-RXN_controller."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/18; endpoint types: /individuals/16/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-020_6f1175838337	gomodel:RXN3O-9805	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9805 RO:0002234 gomodel:CHEBI_29888_RXN3O-9805."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/19; endpoint types: /individuals/20/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-021_34034cf1276c	gomodel:RXN3O-9805	RO:0002234	CHEBI:58179	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9805 RO:0002234 gomodel:CHEBI_58179_RXN3O-9805."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/20; endpoint types: /individuals/20/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-022_386b55d77bb5	gomodel:FARNESYLTRANSTRANSFERASE-RXN	RO:0002413	gomodel:RXN-8813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:FARNESYLTRANSTRANSFERASE-RXN RO:0002413 gomodel:RXN-8813."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/21; endpoint types: /individuals/16/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-023_ce697406b2c5	gomodel:FPPSYN-RXN	RO:0002233	CHEBI:58057	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:FPPSYN-RXN RO:0002233 gomodel:CHEBI_58057_GPPSYN-RXN."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/22; endpoint types: /individuals/17/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-024_ab465a88a0f9	gomodel:GPPSYN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:GPPSYN-RXN BFO:0000066 gomodel:reaction_GPPSYN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/23; endpoint types: /individuals/18/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-025_67ddf5a206e5	SGD:S000000207	pathwaymech:enables	gomodel:RXN3O-9805	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P18900|gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9805 RO:0002333 gomodel:YBR003W-MONOMER_RXN3O-9805_controller."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/24; endpoint types: /individuals/20/type; /individuals/21/type""}, {""reference_id"": ""UniProtKB:P18900"", ""source_assertion"": ""UniProtKB:P18900 is the yeast mitochondrial hexaprenyl pyrophosphate synthase COQ1; the native RXN3O-9805 product is hexaprenyl diphosphate, not heptaprenyl diphosphate."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3319/proteinDescription/recommendedName""}]"	"[{""id"": ""UniProtKB:P18900"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P18900 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-026_e4703ad2eb7a	gomodel:RXN-8813	RO:0002233	CHEBI:128769	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN-8813 RO:0002233 gomodel:CHEBI_128769_RXN-8813."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/25; endpoint types: /individuals/19/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-027_3a9692d9dcaa	gomodel:RXN3O-9805	BFO:0000066	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9805 BFO:0000066 gomodel:YeastPathways_HEXPPSYN-PWY-2/65692e7e00001769."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/26; endpoint types: /individuals/20/type; /individuals/62/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-028_86728a8e930f	gomodel:RXN-8813	BFO:0000050	GO:0006744	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN-8813 BFO:0000050 gomodel:YeastPathways_HEXPPSYN-PWY-2/YeastPathways_HEXPPSYN-PWY-2."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/27; endpoint types: /individuals/19/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-029_5d324542b14c	gomodel:FPPSYN-RXN	BFO:0000050	GO:0006744	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:FPPSYN-RXN BFO:0000050 gomodel:YeastPathways_HEXPPSYN-PWY-2/YeastPathways_HEXPPSYN-PWY-2."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/28; endpoint types: /individuals/17/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-030_a975d873ee50	gomodel:FPPSYN-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:FPPSYN-RXN RO:0002234 gomodel:CHEBI_29888_FPPSYN-RXN."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/29; endpoint types: /individuals/17/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-031_581804a838ff	gomodel:RXN3O-9805	RO:0002233	CHEBI:57907	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9805 RO:0002233 gomodel:CHEBI_57907_RXN-8813."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/30; endpoint types: /individuals/20/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-032_89df80e18a96	gomodel:FPPSYN-RXN	RO:0002413	gomodel:FARNESYLTRANSTRANSFERASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:FPPSYN-RXN RO:0002413 gomodel:FARNESYLTRANSTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/31; endpoint types: /individuals/17/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-033_5b581b7fa28c	gomodel:FPPSYN-RXN	RO:0002233	CHEBI:128769	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:FPPSYN-RXN RO:0002233 gomodel:CHEBI_128769_FPPSYN-RXN."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/32; endpoint types: /individuals/17/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-034_f1312c8de552	gomodel:GPPSYN-RXN	RO:0002234	CHEBI:58057	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:GPPSYN-RXN RO:0002234 gomodel:CHEBI_58057_GPPSYN-RXN."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/33; endpoint types: /individuals/18/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-035_008eb28ee654	gomodel:FARNESYLTRANSTRANSFERASE-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:FARNESYLTRANSTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_29888_FARNESYLTRANSTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/34; endpoint types: /individuals/16/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-036_8eb56297d350	gomodel:RXN-8813	RO:0002413	gomodel:RXN3O-9805	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN-8813 RO:0002413 gomodel:RXN3O-9805."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/35; endpoint types: /individuals/19/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-037_051e2d9fc702	SGD:S000003703	pathwaymech:enables	gomodel:GPPSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:GPPSYN-RXN RO:0002333 gomodel:YJL167W-MONOMER_GPPSYN-RXN_controller."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/36; endpoint types: /individuals/18/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-038_a713c93d9ef4	gomodel:FARNESYLTRANSTRANSFERASE-RXN	BFO:0000066	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:FARNESYLTRANSTRANSFERASE-RXN BFO:0000066 gomodel:YeastPathways_HEXPPSYN-PWY-2/65692e7e00001772."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/37; endpoint types: /individuals/16/type; /individuals/64/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_edge-039_e44689d5ed8f	gomodel:FPPSYN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HEXPPSYN-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_assertion"": ""The model asserts gomodel:FPPSYN-RXN BFO:0000066 gomodel:reaction_FPPSYN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_HEXPPSYN-PWY-2.json#/facts/38; endpoint types: /individuals/17/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_HEXPPSYN-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json"", ""title"": ""GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_location-e7352b805406_9ea78d4e4014	SGD:S000005990	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12051	Physical protein location from reviewed UniProt. ECO:0000250	"[{""reference_id"": ""UniProtKB:Q12051"", ""source_assertion"": ""UniProtKB:Q12051 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2964/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q12051"", ""source_assertion"": ""UniProtKB:Q12051 has the exact SGD cross-reference SGD:S000005990."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2964/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q12051"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12051 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_location-1157a0eb7a6e_0df6c3f8c670	SGD:S000000207	RO:0001025	GO:0005743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P18900	Physical protein location from reviewed UniProt. evidence code not specified by source Topology: Peripheral membrane protein. Orientation: Matrix side.	"[{""reference_id"": ""UniProtKB:P18900"", ""source_assertion"": ""UniProtKB:P18900 annotates location Mitochondrion inner membrane (SL-0168)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3319/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P18900"", ""source_assertion"": ""UniProtKB:P18900 has the exact SGD cross-reference SGD:S000000207."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3319/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P18900"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P18900 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_cofactor-73954f3c0fc0_e2acf29bb522	SGD:S000003703	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08524	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q12051) Binds 2 Mg(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:Q12051)	"[{""reference_id"": ""UniProtKB:P08524"", ""source_assertion"": ""UniProtKB:P08524 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/209/comments/0/cofactors/0; /results/209/comments/0/note""}, {""reference_id"": ""UniProtKB:P08524"", ""source_assertion"": ""UniProtKB:P08524 has the exact SGD cross-reference SGD:S000003703."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/209/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P08524"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P08524 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_cofactor-d087dae6bd89_cf729481ab3b	SGD:S000005990	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12051	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:17535895) Binds 2 Mg(2+) ions per subunit. UniProt note evidence: ECO:0000269 (PubMed:17535895)	"[{""reference_id"": ""UniProtKB:Q12051"", ""source_assertion"": ""UniProtKB:Q12051 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2964/comments/0/cofactors/0; /results/2964/comments/0/note""}, {""reference_id"": ""UniProtKB:Q12051"", ""source_assertion"": ""UniProtKB:Q12051 has the exact SGD cross-reference SGD:S000005990."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2964/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q12051"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12051 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HEXPPSYN-PWY-2_cofactor-aaeed82093fc_4e276c20b3e4	SGD:S000000207	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P18900	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 2 Mg(2+) ions per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P18900"", ""source_assertion"": ""UniProtKB:P18900 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3319/comments/0/cofactors/0; /results/3319/comments/0/note""}, {""reference_id"": ""UniProtKB:P18900"", ""source_assertion"": ""UniProtKB:P18900 has the exact SGD cross-reference SGD:S000000207."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3319/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P18900"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P18900 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-001_0095bd0830f5	gomodel:CYSTAGLY-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTAGLY-RXN RO:0002233 gomodel:CHEBI_15377_CYSTAGLY-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/0; endpoint types: /individuals/14/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-002_efa5b1ce6182	gomodel:CYSTAGLY-RXN	RO:0002234	CHEBI:16134	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTAGLY-RXN RO:0002234 gomodel:CHEBI_16134_CYSTAGLY-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/1; endpoint types: /individuals/14/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-003_c91b95f9ab42	gomodel:CYSTAGLY-RXN	BFO:0000050	GO:0050667	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTAGLY-RXN BFO:0000050 gomodel:YeastPathways_HOMOCYS-CYS-CONVERT/YeastPathways_HOMOCYS-CYS-CONVERT."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/2; endpoint types: /individuals/14/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-004_589cd08a7e90	gomodel:CYSTATHIONINE-BETA-LYASE-RXN	RO:0002234	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-LYASE-RXN RO:0002234 gomodel:CHEBI_15361_CYSTATHIONINE-BETA-LYASE-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/3; endpoint types: /individuals/15/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-005_356facfe595e	gomodel:CYSTATHIONINE-BETA-LYASE-RXN	RO:0002234	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-LYASE-RXN RO:0002234 gomodel:CHEBI_28938_CYSTATHIONINE-BETA-LYASE-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/4; endpoint types: /individuals/15/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-006_2b32120d4e11	gomodel:RXN-721	RO:0002234	CHEBI:30089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:RXN-721 RO:0002234 gomodel:CHEBI_30089_RXN-721."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/5; endpoint types: /individuals/17/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-007_611f37ba46a2	gomodel:CYSTATHIONINE-BETA-LYASE-RXN	RO:0002233	CHEBI:58161	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-LYASE-RXN RO:0002233 gomodel:CHEBI_58161_RXN-721."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/6; endpoint types: /individuals/15/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-008_7225b8348db8	SGD:S000003152	pathwaymech:enables	gomodel:CYSTATHIONINE-BETA-LYASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-LYASE-RXN RO:0002333 gomodel:YGL184C-MONOMER_CYSTATHIONINE-BETA-LYASE-RXN_controller."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/7; endpoint types: /individuals/15/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-009_ff1ca1f6d430	gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_15377_CYSTATHIONINE-BETA-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/8; endpoint types: /individuals/16/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-010_c82db8516bd6	gomodel:CYSTATHIONINE-BETA-LYASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-LYASE-RXN BFO:0000066 gomodel:reaction_CYSTATHIONINE-BETA-LYASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/9; endpoint types: /individuals/15/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-011_c8f59fc9910a	gomodel:CYSTATHIONINE-BETA-LYASE-RXN	BFO:0000050	GO:0050667	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-LYASE-RXN BFO:0000050 gomodel:YeastPathways_HOMOCYS-CYS-CONVERT/YeastPathways_HOMOCYS-CYS-CONVERT."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/10; endpoint types: /individuals/15/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-012_8165f89eff0d	gomodel:RXN-721	RO:0002233	CHEBI:57716	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:RXN-721 RO:0002233 gomodel:CHEBI_57716_RXN-721."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/11; endpoint types: /individuals/17/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-013_ade5da1253d8	gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN BFO:0000066 gomodel:reaction_CYSTATHIONINE-BETA-SYNTHASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/12; endpoint types: /individuals/16/type; /individuals/50/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-014_38d189d678d1	gomodel:RXN-721	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:RXN-721 BFO:0000066 gomodel:reaction_RXN-721_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/13; endpoint types: /individuals/17/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-015_3457c96f7f3d	gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN	RO:0002233	CHEBI:33384	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_33384_CYSTATHIONINE-BETA-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/14; endpoint types: /individuals/16/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-016_9eddcedc44c2	gomodel:RXN-721	BFO:0000050	GO:0050667	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:RXN-721 BFO:0000050 gomodel:YeastPathways_HOMOCYS-CYS-CONVERT/YeastPathways_HOMOCYS-CYS-CONVERT."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/15; endpoint types: /individuals/17/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-017_ae99ebcfa14f	SGD:S000000010	pathwaymech:enables	gomodel:CYSTAGLY-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTAGLY-RXN RO:0002333 gomodel:YAL012W-MONOMER_CYSTAGLY-RXN_controller."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/16; endpoint types: /individuals/14/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-018_cabe49f8812f	gomodel:CYSTATHIONINE-BETA-LYASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-LYASE-RXN RO:0002233 gomodel:CHEBI_15377_CYSTATHIONINE-BETA-LYASE-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/17; endpoint types: /individuals/15/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-019_65f7672b1080	gomodel:RXN-721	RO:0002233	CHEBI:35235	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:RXN-721 RO:0002233 gomodel:CHEBI_35235_CYSTAGLY-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/18; endpoint types: /individuals/17/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-020_aea3e433afb4	gomodel:CYSTAGLY-RXN	RO:0002233	CHEBI:58161	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTAGLY-RXN RO:0002233 gomodel:CHEBI_58161_RXN-721."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/19; endpoint types: /individuals/14/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-021_313dcef641b7	gomodel:CYSTAGLY-RXN	RO:0002234	CHEBI:16763	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTAGLY-RXN RO:0002234 gomodel:CHEBI_16763_CYSTAGLY-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/20; endpoint types: /individuals/14/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-022_4b86f480757b	SGD:S000003387	pathwaymech:enables	gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN RO:0002333 gomodel:YGR155W-MONOMER_CYSTATHIONINE-BETA-SYNTHASE-RXN_controller."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/21; endpoint types: /individuals/16/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-023_f7032e06c116	gomodel:CYSTAGLY-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTAGLY-RXN BFO:0000066 gomodel:reaction_CYSTAGLY-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/22; endpoint types: /individuals/14/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-024_37bf9d4990d4	gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN	BFO:0000050	GO:0050667	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN BFO:0000050 gomodel:YeastPathways_HOMOCYS-CYS-CONVERT/YeastPathways_HOMOCYS-CYS-CONVERT."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/23; endpoint types: /individuals/16/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-025_31d256a4eedd	gomodel:CYSTATHIONINE-BETA-LYASE-RXN	RO:0002234	CHEBI:58199	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-LYASE-RXN RO:0002234 gomodel:CHEBI_58199_CYSTATHIONINE-BETA-LYASE-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/24; endpoint types: /individuals/15/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-026_7e60d6994850	gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN	RO:0002233	CHEBI:58199	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_58199_CYSTATHIONINE-BETA-LYASE-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/25; endpoint types: /individuals/16/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-027_cc6903863452	gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN	RO:0002234	CHEBI:58161	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_58161_CYSTATHIONINE-BETA-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/26; endpoint types: /individuals/16/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-028_85ee55457bc3	SGD:S000003891	pathwaymech:enables	gomodel:RXN-721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000003891|gomodel:YeastPathways_HOMOCYS-CYS-CONVERT	Retain the native O-acetylhomoserine reaction: inspected YeastCyc STR2 lists both O-acetyl and O-succinyl reactions. UniProt P47164 lists only O-succinylhomoserine; that difference does not disprove the O-acetyl route.	"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:RXN-721 RO:0002333 gomodel:YJR130C-MONOMER_RXN-721_controller."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/27; endpoint types: /individuals/17/type; /individuals/21/type""}, {""reference_id"": ""SGD:S000003891"", ""source_assertion"": ""YeastCyc STR2 lists RXN-721: L-cysteine + O-acetyl-L-homoserine -> L-cystathionine + acetate, as well as O-SUCCHOMOSERLYASE-RXN with O-succinyl-L-homoserine."", ""source_locator"": ""https://pathway.yeastgenome.org/gene?id=YJR130C&orgid=YEAST [sha256:ea882c3e1f62e6e4d44e3d5b9851f6899b2b7c69b15d38f27ee169abd20e6917] Reactions table / RXN-721 and O-SUCCHOMOSERLYASE-RXN""}]"	"[{""id"": ""SGD:S000003891"", ""source_sha256"": ""ea882c3e1f62e6e4d44e3d5b9851f6899b2b7c69b15d38f27ee169abd20e6917"", ""source_version"": ""YeastCyc 22.5; retrieved 2026-10-05"", ""title"": ""YeastCyc STR2: two annotated reactions"", ""url"": ""https://pathway.yeastgenome.org/gene?id=YJR130C&orgid=YEAST""}, {""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-029_41960d37c069	gomodel:RXN-721	RO:0002234	CHEBI:58161	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:RXN-721 RO:0002234 gomodel:CHEBI_58161_RXN-721."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/28; endpoint types: /individuals/17/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_edge-030_8040578924c4	gomodel:CYSTAGLY-RXN	RO:0002234	CHEBI:35235	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYS-CYS-CONVERT		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_assertion"": ""The model asserts gomodel:CYSTAGLY-RXN RO:0002234 gomodel:CHEBI_35235_CYSTAGLY-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYS-CYS-CONVERT.json#/facts/29; endpoint types: /individuals/14/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYS-CYS-CONVERT"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-25; member ./YeastPathways_HOMOCYS-CYS-CONVERT.json"", ""title"": ""SGD GO-CAM homocysteine and cysteine interconversion - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_location-47eae32ac9ae_3996048b12b6	SGD:S000003152	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53101	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P53101"", ""source_assertion"": ""UniProtKB:P53101 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3936/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53101"", ""source_assertion"": ""UniProtKB:P53101 has the exact SGD cross-reference SGD:S000003152."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3936/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53101"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53101 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_location-21071206d39d_cb08cca7c901	SGD:S000003152	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53101	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P53101"", ""source_assertion"": ""UniProtKB:P53101 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3936/comments/0/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53101"", ""source_assertion"": ""UniProtKB:P53101 has the exact SGD cross-reference SGD:S000003152."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3936/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53101"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53101 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_location-c78838968de5_4455f48b9d9a	SGD:S000000010	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31373	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P31373"", ""source_assertion"": ""UniProtKB:P31373 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/839/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P31373"", ""source_assertion"": ""UniProtKB:P31373 has the exact SGD cross-reference SGD:S000000010."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/839/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P31373"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P31373 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_location-0453de062256_ba08517f5e8c	SGD:S000003891	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47164	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P47164"", ""source_assertion"": ""UniProtKB:P47164 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1983/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P47164"", ""source_assertion"": ""UniProtKB:P47164 has the exact SGD cross-reference SGD:S000003891."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1983/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P47164"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47164 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_location-170ac4135132_44027d9c5681	SGD:S000003891	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47164	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P47164"", ""source_assertion"": ""UniProtKB:P47164 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1983/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P47164"", ""source_assertion"": ""UniProtKB:P47164 has the exact SGD cross-reference SGD:S000003891."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1983/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P47164"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47164 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_cofactor-c9f242303a7f_e939cf51abbd	SGD:S000003152	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53101	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P53101"", ""source_assertion"": ""UniProtKB:P53101 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3936/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P53101"", ""source_assertion"": ""UniProtKB:P53101 has the exact SGD cross-reference SGD:S000003152."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3936/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53101"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53101 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_cofactor-61049165bd4d_0c0ee75d46dc	SGD:S000000010	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31373	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:12715888)	"[{""reference_id"": ""UniProtKB:P31373"", ""source_assertion"": ""UniProtKB:P31373 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/839/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P31373"", ""source_assertion"": ""UniProtKB:P31373 has the exact SGD cross-reference SGD:S000000010."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/839/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P31373"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P31373 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_cofactor-c111bc18655d_d8269a73d0e4	SGD:S000003387	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32582	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P32582"", ""source_assertion"": ""UniProtKB:P32582 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/958/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P32582"", ""source_assertion"": ""UniProtKB:P32582 has the exact SGD cross-reference SGD:S000003387."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/958/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32582"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P32582 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYS-CYS-CONVERT_cofactor-3850ca607a71_91a9dc6a07ae	SGD:S000003891	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47164	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P32929)	"[{""reference_id"": ""UniProtKB:P47164"", ""source_assertion"": ""UniProtKB:P47164 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1983/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P47164"", ""source_assertion"": ""UniProtKB:P47164 has the exact SGD cross-reference SGD:S000003891."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1983/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P47164"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47164 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:GO_1902000_hmg-edge-001_1eca76ae38c7	CHEBI:16169	pathwaymech:consumes	RHEA:15450	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15450		"[{""reference_id"": ""RHEA:15450"", ""source_assertion"": ""Rhea assigns CHEBI:16169 to the substrates of RHEA:15450, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15450']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/15449_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_15449_compound_5206']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_15449_compound_5206']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_5206']/rh:chebi""}]"	"[{""id"": ""RHEA:15450"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF, exact native triples projected in author dossier"", ""title"": ""Rhea directed reaction 15450"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1902000_hmg-edge-002_bd782882b591	CHEBI:15379	pathwaymech:consumes	RHEA:15450	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15450		"[{""reference_id"": ""RHEA:15450"", ""source_assertion"": ""Rhea assigns CHEBI:15379 to the substrates of RHEA:15450, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15450']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/15449_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_15449_compound_1198']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_15449_compound_1198']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_1198']/rh:chebi""}]"	"[{""id"": ""RHEA:15450"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF, exact native triples projected in author dossier"", ""title"": ""Rhea directed reaction 15450"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1902000_hmg-edge-003_129149a35f96	RHEA:15450	pathwaymech:produces	CHEBI:17105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15450		"[{""reference_id"": ""RHEA:15450"", ""source_assertion"": ""Rhea assigns CHEBI:17105 to the products of RHEA:15450, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15450']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/15449_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_15449_compound_5213']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_15449_compound_5213']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_5213']/rh:chebi""}]"	"[{""id"": ""RHEA:15450"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF, exact native triples projected in author dossier"", ""title"": ""Rhea directed reaction 15450"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1902000_hmg-edge-004_fcc099eef5c8	RHEA:15450	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15450		"[{""reference_id"": ""RHEA:15450"", ""source_assertion"": ""Rhea assigns CHEBI:15378 to the products of RHEA:15450, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15450']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/15449_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_15449_compound_3249']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_15449_compound_3249']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3249']/rh:chebi""}]"	"[{""id"": ""RHEA:15450"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF, exact native triples projected in author dossier"", ""title"": ""Rhea directed reaction 15450"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1902000_hmg-edge-005_82faca4ce0d0	CHEBI:17105	pathwaymech:consumes	RHEA:14818	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14818		"[{""reference_id"": ""RHEA:14818"", ""source_assertion"": ""Rhea assigns CHEBI:17105 to the substrates of RHEA:14818, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14818']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/14817_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_14817_compound_5213']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_14817_compound_5213']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_5213']/rh:chebi""}]"	"[{""id"": ""RHEA:14818"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF, exact native triples projected in author dossier"", ""title"": ""Rhea directed reaction 14818"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1902000_hmg-edge-006_66e21960ed06	RHEA:14818	pathwaymech:produces	CHEBI:18034	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14818		"[{""reference_id"": ""RHEA:14818"", ""source_assertion"": ""Rhea assigns CHEBI:18034 to the products of RHEA:14818, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14818']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/14817_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_14817_compound_4618']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_14817_compound_4618']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_4618']/rh:chebi""}]"	"[{""id"": ""RHEA:14818"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF, exact native triples projected in author dossier"", ""title"": ""Rhea directed reaction 14818"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1902000_hmg-edge-007_5a93179b45d1	CHEBI:18034	pathwaymech:consumes	RHEA:10245	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10245		"[{""reference_id"": ""RHEA:10245"", ""source_assertion"": ""Rhea assigns CHEBI:18034 to the substrates of RHEA:10245, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10245']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/10244_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_10244_compound_4618']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_10244_compound_4618']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_4618']/rh:chebi""}]"	"[{""id"": ""RHEA:10245"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF, exact native triples projected in author dossier"", ""title"": ""Rhea directed reaction 10245"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1902000_hmg-edge-008_50d103f1f158	CHEBI:15377	pathwaymech:consumes	RHEA:10245	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10245		"[{""reference_id"": ""RHEA:10245"", ""source_assertion"": ""Rhea assigns CHEBI:15377 to the substrates of RHEA:10245, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10245']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/10244_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_10244_compound_1283']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_10244_compound_1283']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_1283']/rh:chebi""}]"	"[{""id"": ""RHEA:10245"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF, exact native triples projected in author dossier"", ""title"": ""Rhea directed reaction 10245"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1902000_hmg-edge-009_a0aa3c84524e	RHEA:10245	pathwaymech:produces	CHEBI:13705	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10245		"[{""reference_id"": ""RHEA:10245"", ""source_assertion"": ""Rhea assigns CHEBI:13705 to the products of RHEA:10245, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10245']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/10244_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_10244_compound_3307']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_10244_compound_3307']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3307']/rh:chebi""}]"	"[{""id"": ""RHEA:10245"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF, exact native triples projected in author dossier"", ""title"": ""Rhea directed reaction 10245"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1902000_hmg-edge-010_60e485b8602e	RHEA:10245	pathwaymech:produces	CHEBI:29806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10245		"[{""reference_id"": ""RHEA:10245"", ""source_assertion"": ""Rhea assigns CHEBI:29806 to the products of RHEA:10245, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10245']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/10244_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_10244_compound_3031']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_10244_compound_3031']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3031']/rh:chebi""}]"	"[{""id"": ""RHEA:10245"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF, exact native triples projected in author dossier"", ""title"": ""Rhea directed reaction 10245"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1902000_hmg-edge-011_4dea20f27117	RHEA:10245	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10245		"[{""reference_id"": ""RHEA:10245"", ""source_assertion"": ""Rhea assigns CHEBI:15378 to the products of RHEA:10245, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10245']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/10244_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_10244_compound_3249']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_10244_compound_3249']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3249']/rh:chebi""}]"	"[{""id"": ""RHEA:10245"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF, exact native triples projected in author dossier"", ""title"": ""Rhea directed reaction 10245"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1902000_hmg-edge-012_e5f3542dc07b	UniProtKB:Q6EMI9	pathwaymech:enables	RHEA:15450	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:15262943|RHEA:15450|UniProtKB:Q6EMI9	Functional gene-product assignment from the native study and exact deposited sequence; no isolated-monomer catalytic unit is asserted. The strain U hexamer annotation is inferred by HAMAP; KT2440 structural experiments are separate.	"[{""reference_id"": ""PMID:15262943"", ""source_assertion"": ""Figure 1B assigns homogentisate ring cleavage to hmgA in the strain U homogentisate pathway; gene disruptions support pathway function."", ""source_locator"": ""Arias-Barrau et al. (2004), Fig. 1B (p. 5063); Results and Discussion, Identification of the genes involved in the central pathway (pp. 5067-5069); Fig. 5.""}, {""reference_id"": ""UniProtKB:Q6EMI9"", ""source_assertion"": ""Q6EMI9 links hmgA to deposited strain U protein AAO12527.1 in AY168855, the sequence reported in PMID:15262943."", ""source_locator"": ""/results/0/genes/0/geneName; /results/0/uniProtKBCrossReferences[database=EMBL,id=AY168855]; /results/0/references/0/referenceComments[type=STRAIN]""}, {""reference_id"": ""RHEA:15450"", ""source_assertion"": ""Rhea master 15449 has directed member 15450; its forward equation represents homogentisate ring cleavage."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15449']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/15450']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/15450']/rh:equation; rh:substrates; rh:products""}, {""reference_id"": ""UniProtKB:Q6EMI9"", ""source_assertion"": ""Reviewed HmgA assigns this reaction to RHEA:15449 using HAMAP MF_00334 (ECO:0000255); its hexamer, a dimer of trimers, is also a HAMAP inference."", ""source_locator"": ""/results/0/comments/1/reaction; /results/0/comments/4""}]"	"[{""id"": ""PMID:15262943"", ""source_sha256"": ""3376702d6a5532036127514c819a777ebe2ea8546f917306f05314250ccb2ac8"", ""source_version"": ""Journal of Bacteriology 186:5062-5077 (2004); complete 16-page primary PDF, relevant figure, methods and results inspected"", ""title"": ""The homogentisate pathway: a central catabolic pathway involved in the degradation of L-phenylalanine, L-tyrosine, and 3-hydroxyphenylacetate in Pseudomonas putida."", ""url"": ""https://europepmc.org/articles/PMC451635?pdf=render""}, {""id"": ""RHEA:15450"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF, exact native triples projected in author dossier"", ""title"": ""Rhea directed reaction 15450"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:Q6EMI9"", ""source_sha256"": ""47e1db788538e999e1b5b29f9ba0083b48995dd40531ed184e36ac5eb12bfaa9"", ""source_version"": ""Native four-entry AY168855 response; Q6EMI9 entry version 76, sequence version 1, annotation updated 2026-01-28"", ""title"": ""UniProtKB reviewed (Swiss-Prot) Q6EMI9: native sequence, function and annotation evidence"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=AY168855&format=json&size=500""}]"	""
pathwaymech:GO_1902000_hmg-edge-013_6e0c5c1680cb	UniProtKB:Q6EMI7	pathwaymech:enables	RHEA:14818	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:15262943|RHEA:14818|UniProtKB:Q6EMI7	Functional gene-product assignment from the native study and exact deposited sequence; no isolated-monomer catalytic unit is asserted. The UniProt entry is unreviewed; the primary evidence is genetics and sequence-based functional assignment, not a purified-enzyme assay of this strain U protein.	"[{""reference_id"": ""PMID:15262943"", ""source_assertion"": ""Figure 1B assigns maleylacetoacetate isomerization to hmgC in the strain U homogentisate pathway; gene disruptions support pathway function."", ""source_locator"": ""Arias-Barrau et al. (2004), Fig. 1B (p. 5063); Results and Discussion, Identification of the genes involved in the central pathway (pp. 5067-5069); Fig. 5.""}, {""reference_id"": ""UniProtKB:Q6EMI7"", ""source_assertion"": ""Q6EMI7 links hmgC to deposited strain U protein AAO12529.1 in AY168855, the sequence reported in PMID:15262943."", ""source_locator"": ""/results/2/genes/0/geneName; /results/2/uniProtKBCrossReferences[database=EMBL,id=AY168855]; /results/2/references/0/referenceComments[type=STRAIN]""}, {""reference_id"": ""RHEA:14818"", ""source_assertion"": ""Rhea master 14817 has directed member 14818; its forward equation represents maleylacetoacetate isomerization."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14817']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/14818']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/14818']/rh:equation; rh:substrates; rh:products""}]"	"[{""id"": ""PMID:15262943"", ""source_sha256"": ""3376702d6a5532036127514c819a777ebe2ea8546f917306f05314250ccb2ac8"", ""source_version"": ""Journal of Bacteriology 186:5062-5077 (2004); complete 16-page primary PDF, relevant figure, methods and results inspected"", ""title"": ""The homogentisate pathway: a central catabolic pathway involved in the degradation of L-phenylalanine, L-tyrosine, and 3-hydroxyphenylacetate in Pseudomonas putida."", ""url"": ""https://europepmc.org/articles/PMC451635?pdf=render""}, {""id"": ""RHEA:14818"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF, exact native triples projected in author dossier"", ""title"": ""Rhea directed reaction 14818"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:Q6EMI7"", ""source_sha256"": ""47e1db788538e999e1b5b29f9ba0083b48995dd40531ed184e36ac5eb12bfaa9"", ""source_version"": ""Native four-entry AY168855 response; Q6EMI7 entry version 79, sequence version 1, annotation updated 2026-09-02"", ""title"": ""UniProtKB unreviewed (TrEMBL) Q6EMI7: native sequence, function and annotation evidence"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=AY168855&format=json&size=500""}]"	""
pathwaymech:GO_1902000_hmg-edge-014_24e727107e32	UniProtKB:Q6EMI8	pathwaymech:enables	RHEA:10245	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:15262943|RHEA:10245|UniProtKB:Q6EMI8	Functional gene-product assignment from the native study and exact deposited sequence; no isolated-monomer catalytic unit is asserted. The UniProt entry is unreviewed; the primary evidence is genetics and sequence-based functional assignment, not a purified-enzyme assay of this strain U protein.	"[{""reference_id"": ""PMID:15262943"", ""source_assertion"": ""Figure 1B assigns fumarylacetoacetate hydrolysis to hmgB in the strain U homogentisate pathway; gene disruptions support pathway function."", ""source_locator"": ""Arias-Barrau et al. (2004), Fig. 1B (p. 5063); Results and Discussion, Identification of the genes involved in the central pathway (pp. 5067-5069); Fig. 5.""}, {""reference_id"": ""UniProtKB:Q6EMI8"", ""source_assertion"": ""Q6EMI8 links hmgB to deposited strain U protein AAO12528.1 in AY168855, the sequence reported in PMID:15262943."", ""source_locator"": ""/results/1/genes/0/geneName; /results/1/uniProtKBCrossReferences[database=EMBL,id=AY168855]; /results/1/references/0/referenceComments[type=STRAIN]""}, {""reference_id"": ""RHEA:10245"", ""source_assertion"": ""Rhea master 10244 has directed member 10245; its forward equation represents fumarylacetoacetate hydrolysis."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10244']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/10245']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/10245']/rh:equation; rh:substrates; rh:products""}]"	"[{""id"": ""PMID:15262943"", ""source_sha256"": ""3376702d6a5532036127514c819a777ebe2ea8546f917306f05314250ccb2ac8"", ""source_version"": ""Journal of Bacteriology 186:5062-5077 (2004); complete 16-page primary PDF, relevant figure, methods and results inspected"", ""title"": ""The homogentisate pathway: a central catabolic pathway involved in the degradation of L-phenylalanine, L-tyrosine, and 3-hydroxyphenylacetate in Pseudomonas putida."", ""url"": ""https://europepmc.org/articles/PMC451635?pdf=render""}, {""id"": ""RHEA:10245"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF, exact native triples projected in author dossier"", ""title"": ""Rhea directed reaction 10245"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:Q6EMI8"", ""source_sha256"": ""47e1db788538e999e1b5b29f9ba0083b48995dd40531ed184e36ac5eb12bfaa9"", ""source_version"": ""Native four-entry AY168855 response; Q6EMI8 entry version 72, sequence version 1, annotation updated 2026-09-02"", ""title"": ""UniProtKB unreviewed (TrEMBL) Q6EMI8: native sequence, function and annotation evidence"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=AY168855&format=json&size=500""}]"	""
pathwaymech:GO_1902000_hmg-edge-015_a6086413ff4c	RHEA:15450	BFO:0000050	GO:1902000	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:1902000|PMID:15262943		"[{""reference_id"": ""PMID:15262943"", ""source_assertion"": ""The boxed central pathway in Fig. 1B includes the ring cleavage step from homogentisate toward fumarate and acetoacetate."", ""source_locator"": ""Arias-Barrau et al. (2004), Fig. 1B (p. 5063), boxed central pathway.""}, {""reference_id"": ""GO:1902000"", ""source_assertion"": ""GO:1902000 denotes homogentisate breakdown and is a non-obsolete biological-process term."", ""source_locator"": ""/results/0/id; /results/0/name; /results/0/definition/text; /results/0/isObsolete; /results/0/aspect""}]"	"[{""id"": ""GO:1902000"", ""source_sha256"": ""468663419157fd6a6c8f8fc08b28314a3a4581c8cef5596873240f44fe5e7218"", ""source_version"": ""QuickGO response retrieved 2026-10-11"", ""title"": ""Gene Ontology homogentisate catabolic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:1902000""}, {""id"": ""PMID:15262943"", ""source_sha256"": ""3376702d6a5532036127514c819a777ebe2ea8546f917306f05314250ccb2ac8"", ""source_version"": ""Journal of Bacteriology 186:5062-5077 (2004); complete 16-page primary PDF, relevant figure, methods and results inspected"", ""title"": ""The homogentisate pathway: a central catabolic pathway involved in the degradation of L-phenylalanine, L-tyrosine, and 3-hydroxyphenylacetate in Pseudomonas putida."", ""url"": ""https://europepmc.org/articles/PMC451635?pdf=render""}]"	""
pathwaymech:GO_1902000_hmg-edge-016_f7bfc5c9742c	RHEA:14818	BFO:0000050	GO:1902000	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:1902000|PMID:15262943		"[{""reference_id"": ""PMID:15262943"", ""source_assertion"": ""The boxed central pathway in Fig. 1B includes the isomerization step from homogentisate toward fumarate and acetoacetate."", ""source_locator"": ""Arias-Barrau et al. (2004), Fig. 1B (p. 5063), boxed central pathway.""}, {""reference_id"": ""GO:1902000"", ""source_assertion"": ""GO:1902000 denotes homogentisate breakdown and is a non-obsolete biological-process term."", ""source_locator"": ""/results/0/id; /results/0/name; /results/0/definition/text; /results/0/isObsolete; /results/0/aspect""}]"	"[{""id"": ""GO:1902000"", ""source_sha256"": ""468663419157fd6a6c8f8fc08b28314a3a4581c8cef5596873240f44fe5e7218"", ""source_version"": ""QuickGO response retrieved 2026-10-11"", ""title"": ""Gene Ontology homogentisate catabolic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:1902000""}, {""id"": ""PMID:15262943"", ""source_sha256"": ""3376702d6a5532036127514c819a777ebe2ea8546f917306f05314250ccb2ac8"", ""source_version"": ""Journal of Bacteriology 186:5062-5077 (2004); complete 16-page primary PDF, relevant figure, methods and results inspected"", ""title"": ""The homogentisate pathway: a central catabolic pathway involved in the degradation of L-phenylalanine, L-tyrosine, and 3-hydroxyphenylacetate in Pseudomonas putida."", ""url"": ""https://europepmc.org/articles/PMC451635?pdf=render""}]"	""
pathwaymech:GO_1902000_hmg-edge-017_522745e21e74	RHEA:10245	BFO:0000050	GO:1902000	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:1902000|PMID:15262943		"[{""reference_id"": ""PMID:15262943"", ""source_assertion"": ""The boxed central pathway in Fig. 1B includes the hydrolysis step from homogentisate toward fumarate and acetoacetate."", ""source_locator"": ""Arias-Barrau et al. (2004), Fig. 1B (p. 5063), boxed central pathway.""}, {""reference_id"": ""GO:1902000"", ""source_assertion"": ""GO:1902000 denotes homogentisate breakdown and is a non-obsolete biological-process term."", ""source_locator"": ""/results/0/id; /results/0/name; /results/0/definition/text; /results/0/isObsolete; /results/0/aspect""}]"	"[{""id"": ""GO:1902000"", ""source_sha256"": ""468663419157fd6a6c8f8fc08b28314a3a4581c8cef5596873240f44fe5e7218"", ""source_version"": ""QuickGO response retrieved 2026-10-11"", ""title"": ""Gene Ontology homogentisate catabolic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:1902000""}, {""id"": ""PMID:15262943"", ""source_sha256"": ""3376702d6a5532036127514c819a777ebe2ea8546f917306f05314250ccb2ac8"", ""source_version"": ""Journal of Bacteriology 186:5062-5077 (2004); complete 16-page primary PDF, relevant figure, methods and results inspected"", ""title"": ""The homogentisate pathway: a central catabolic pathway involved in the degradation of L-phenylalanine, L-tyrosine, and 3-hydroxyphenylacetate in Pseudomonas putida."", ""url"": ""https://europepmc.org/articles/PMC451635?pdf=render""}]"	""
pathwaymech:GO_1902000_hmg-edge-018_716299031ae4	RHEA:15450	RO:0002413	RHEA:14818	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:15262943|RHEA:14818|RHEA:15450	Direct material connection by the exact shared intermediate and the primary pathway figure; gene order hmgABC is not used as reaction order.	"[{""reference_id"": ""RHEA:15450"", ""source_assertion"": ""CHEBI:17105 is produced by RHEA:15450; its chemical identity is retained as the next step substrate."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15450']/rh:products; rh:contains1/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:14818"", ""source_assertion"": ""CHEBI:17105 is a substrate of RHEA:14818, connecting the two explicitly assigned chemical steps."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14818']/rh:substrates; rh:contains1/rh:compound/rh:chebi""}, {""reference_id"": ""PMID:15262943"", ""source_assertion"": ""Figure 1B orders the central reactions HmgA, HmgC, then HmgB through their shared intermediates."", ""source_locator"": ""Arias-Barrau et al. (2004), Fig. 1B (p. 5063).""}]"	"[{""id"": ""PMID:15262943"", ""source_sha256"": ""3376702d6a5532036127514c819a777ebe2ea8546f917306f05314250ccb2ac8"", ""source_version"": ""Journal of Bacteriology 186:5062-5077 (2004); complete 16-page primary PDF, relevant figure, methods and results inspected"", ""title"": ""The homogentisate pathway: a central catabolic pathway involved in the degradation of L-phenylalanine, L-tyrosine, and 3-hydroxyphenylacetate in Pseudomonas putida."", ""url"": ""https://europepmc.org/articles/PMC451635?pdf=render""}, {""id"": ""RHEA:14818"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF, exact native triples projected in author dossier"", ""title"": ""Rhea directed reaction 14818"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:15450"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF, exact native triples projected in author dossier"", ""title"": ""Rhea directed reaction 15450"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1902000_hmg-edge-019_9be6dcf690db	RHEA:14818	RO:0002413	RHEA:10245	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:15262943|RHEA:10245|RHEA:14818	Direct material connection by the exact shared intermediate and the primary pathway figure; gene order hmgABC is not used as reaction order.	"[{""reference_id"": ""RHEA:14818"", ""source_assertion"": ""CHEBI:18034 is produced by RHEA:14818; its chemical identity is retained as the next step substrate."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14818']/rh:products; rh:contains1/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:10245"", ""source_assertion"": ""CHEBI:18034 is a substrate of RHEA:10245, connecting the two explicitly assigned chemical steps."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10245']/rh:substrates; rh:contains1/rh:compound/rh:chebi""}, {""reference_id"": ""PMID:15262943"", ""source_assertion"": ""Figure 1B orders the central reactions HmgA, HmgC, then HmgB through their shared intermediates."", ""source_locator"": ""Arias-Barrau et al. (2004), Fig. 1B (p. 5063).""}]"	"[{""id"": ""PMID:15262943"", ""source_sha256"": ""3376702d6a5532036127514c819a777ebe2ea8546f917306f05314250ccb2ac8"", ""source_version"": ""Journal of Bacteriology 186:5062-5077 (2004); complete 16-page primary PDF, relevant figure, methods and results inspected"", ""title"": ""The homogentisate pathway: a central catabolic pathway involved in the degradation of L-phenylalanine, L-tyrosine, and 3-hydroxyphenylacetate in Pseudomonas putida."", ""url"": ""https://europepmc.org/articles/PMC451635?pdf=render""}, {""id"": ""RHEA:10245"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF, exact native triples projected in author dossier"", ""title"": ""Rhea directed reaction 10245"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:14818"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF, exact native triples projected in author dossier"", ""title"": ""Rhea directed reaction 14818"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_1902000_hmg-edge-020_4a5020c2069a	UniProtKB:Q6EMI9	pathwaymech:has_cofactor	CHEBI:24875	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q6EMI9	Inferred strain U annotation. The broad iron-cation identifier does not assert a measured oxidation state or occupancy for this protein.	"[{""reference_id"": ""UniProtKB:Q6EMI9"", ""source_assertion"": ""Reviewed HmgA annotates an Fe cation cofactor through HAMAP MF_00334 (ECO:0000255)."", ""source_locator"": ""/results/0/comments/2/cofactors/0; /results/0/comments/2/cofactors/0/evidences""}]"	"[{""id"": ""UniProtKB:Q6EMI9"", ""source_sha256"": ""47e1db788538e999e1b5b29f9ba0083b48995dd40531ed184e36ac5eb12bfaa9"", ""source_version"": ""Native four-entry AY168855 response; Q6EMI9 entry version 76, sequence version 1, annotation updated 2026-01-28"", ""title"": ""UniProtKB reviewed (Swiss-Prot) Q6EMI9: native sequence, function and annotation evidence"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=AY168855&format=json&size=500""}]"	""
pathwaymech:GO_1902000_hmg-edge-021_f41c013b2e3f	UniProtKB:Q6EMI8	pathwaymech:has_cofactor	CHEBI:29108	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q6EMI8	Automatic family-level cofactor annotation, not a strain U binding or activity measurement. The separate Ca and Mg annotations do not establish simultaneous requirements or physiological occupancy.	"[{""reference_id"": ""UniProtKB:Q6EMI8"", ""source_assertion"": ""Unreviewed HmgB annotates Ca(2+) through ARBA00001913 and PIRSR605959-3 (ECO:0000256)."", ""source_locator"": ""/results/1/comments/0/cofactors/0; /results/1/comments/0/cofactors/0/evidences""}]"	"[{""id"": ""UniProtKB:Q6EMI8"", ""source_sha256"": ""47e1db788538e999e1b5b29f9ba0083b48995dd40531ed184e36ac5eb12bfaa9"", ""source_version"": ""Native four-entry AY168855 response; Q6EMI8 entry version 72, sequence version 1, annotation updated 2026-09-02"", ""title"": ""UniProtKB unreviewed (TrEMBL) Q6EMI8: native sequence, function and annotation evidence"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=AY168855&format=json&size=500""}]"	""
pathwaymech:GO_1902000_hmg-edge-022_0f5bd93e2f7c	UniProtKB:Q6EMI8	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q6EMI8	Automatic family-level cofactor annotation, not a strain U binding or activity measurement. The separate Ca and Mg annotations do not establish simultaneous requirements or physiological occupancy.	"[{""reference_id"": ""UniProtKB:Q6EMI8"", ""source_assertion"": ""Unreviewed HmgB annotates Mg(2+) through ARBA00001946 and PIRSR605959-3 (ECO:0000256)."", ""source_locator"": ""/results/1/comments/1/cofactors/0; /results/1/comments/1/cofactors/0/evidences""}]"	"[{""id"": ""UniProtKB:Q6EMI8"", ""source_sha256"": ""47e1db788538e999e1b5b29f9ba0083b48995dd40531ed184e36ac5eb12bfaa9"", ""source_version"": ""Native four-entry AY168855 response; Q6EMI8 entry version 72, sequence version 1, annotation updated 2026-09-02"", ""title"": ""UniProtKB unreviewed (TrEMBL) Q6EMI8: native sequence, function and annotation evidence"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=AY168855&format=json&size=500""}]"	""
pathwaymech:GO_1902000_hmg-edge-023_8dacf62501c4	UniProtKB:Q6EMI9	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q6EMI9	Electronic localization annotation; not a direct localization experiment or a claim of exclusive residence.	"[{""reference_id"": ""UniProtKB:Q6EMI9"", ""source_assertion"": ""UniProt links this protein to cytoplasm (GO:0005737) with electronic annotation IEA:TreeGrafter."", ""source_locator"": ""/results/0/uniProtKBCrossReferences/6""}]"	"[{""id"": ""UniProtKB:Q6EMI9"", ""source_sha256"": ""47e1db788538e999e1b5b29f9ba0083b48995dd40531ed184e36ac5eb12bfaa9"", ""source_version"": ""Native four-entry AY168855 response; Q6EMI9 entry version 76, sequence version 1, annotation updated 2026-01-28"", ""title"": ""UniProtKB reviewed (Swiss-Prot) Q6EMI9: native sequence, function and annotation evidence"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=AY168855&format=json&size=500""}]"	""
pathwaymech:GO_1902000_hmg-edge-024_a1deaad9e0b2	UniProtKB:Q6EMI7	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q6EMI7	Electronic localization annotation; not a direct localization experiment or a claim of exclusive residence.	"[{""reference_id"": ""UniProtKB:Q6EMI7"", ""source_assertion"": ""UniProt links this protein to cytoplasm (GO:0005737) with electronic annotation IEA:InterPro."", ""source_locator"": ""/results/2/uniProtKBCrossReferences/4""}]"	"[{""id"": ""UniProtKB:Q6EMI7"", ""source_sha256"": ""47e1db788538e999e1b5b29f9ba0083b48995dd40531ed184e36ac5eb12bfaa9"", ""source_version"": ""Native four-entry AY168855 response; Q6EMI7 entry version 79, sequence version 1, annotation updated 2026-09-02"", ""title"": ""UniProtKB unreviewed (TrEMBL) Q6EMI7: native sequence, function and annotation evidence"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=AY168855&format=json&size=500""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-001_6957e9a9ce6f	CHEBI:16526	pathwaymech:consumes	RHEA:10750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750		"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea places CHEBI:16526 on the substrates side of directed RHEA:10750, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10750/rh:substrates; http://rdf.rhea-db.org/10748_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_10748_compound_4391/rh:compound -> http://rdf.rhea-db.org/Compound_4391/rh:chebi""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 10750 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-002_4d68816f35a6	CHEBI:15377	pathwaymech:consumes	RHEA:10750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750		"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea places CHEBI:15377 on the substrates side of directed RHEA:10750, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10750/rh:substrates; http://rdf.rhea-db.org/10748_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_10748_compound_1283/rh:compound -> http://rdf.rhea-db.org/Compound_1283/rh:chebi""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 10750 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-003_1ef6efa58332	RHEA:10750	pathwaymech:produces	CHEBI:17544	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750		"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea places CHEBI:17544 on the products side of directed RHEA:10750, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10750/rh:products; http://rdf.rhea-db.org/10748_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_10748_compound_1123/rh:compound -> http://rdf.rhea-db.org/Compound_1123/rh:chebi""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 10750 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-004_2af0c3a97959	RHEA:10750	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750		"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""Rhea places CHEBI:15378 on the products side of directed RHEA:10750, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10750/rh:products; http://rdf.rhea-db.org/10748_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_10748_compound_3249/rh:compound -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 10750 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-005_9d7e8be96260	CHEBI:17544	pathwaymech:consumes	RHEA:11309	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11309		"[{""reference_id"": ""RHEA:11309"", ""source_assertion"": ""Rhea places CHEBI:17544 on the substrates side of directed RHEA:11309, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/11309/rh:substrates; http://rdf.rhea-db.org/11308_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_11308_compound_1123/rh:compound -> http://rdf.rhea-db.org/Compound_1123/rh:chebi""}]"	"[{""id"": ""RHEA:11309"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 11309 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-006_0ec987a6b380	CHEBI:57288	pathwaymech:consumes	RHEA:11309	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11309		"[{""reference_id"": ""RHEA:11309"", ""source_assertion"": ""Rhea places CHEBI:57288 on the substrates side of directed RHEA:11309, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/11309/rh:substrates; http://rdf.rhea-db.org/11308_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_11308_compound_4271/rh:compound -> http://rdf.rhea-db.org/Compound_4271/rh:chebi""}]"	"[{""id"": ""RHEA:11309"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 11309 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-007_8b44215a515a	CHEBI:30616	pathwaymech:consumes	RHEA:11309	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11309		"[{""reference_id"": ""RHEA:11309"", ""source_assertion"": ""Rhea places CHEBI:30616 on the substrates side of directed RHEA:11309, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/11309/rh:substrates; http://rdf.rhea-db.org/11308_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_11308_compound_6372/rh:compound -> http://rdf.rhea-db.org/Compound_6372/rh:chebi""}]"	"[{""id"": ""RHEA:11309"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 11309 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-008_0f16c7bc0ccb	RHEA:11309	pathwaymech:produces	CHEBI:57384	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11309		"[{""reference_id"": ""RHEA:11309"", ""source_assertion"": ""Rhea places CHEBI:57384 on the products side of directed RHEA:11309, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/11309/rh:products; http://rdf.rhea-db.org/11308_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_11308_compound_5125/rh:compound -> http://rdf.rhea-db.org/Compound_5125/rh:chebi""}]"	"[{""id"": ""RHEA:11309"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 11309 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-009_2f15493e440c	RHEA:11309	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11309		"[{""reference_id"": ""RHEA:11309"", ""source_assertion"": ""Rhea places CHEBI:456216 on the products side of directed RHEA:11309, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/11309/rh:products; http://rdf.rhea-db.org/11308_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_11308_compound_2710/rh:compound -> http://rdf.rhea-db.org/Compound_2710/rh:chebi""}]"	"[{""id"": ""RHEA:11309"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 11309 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-010_4ebddad5a049	RHEA:11309	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11309		"[{""reference_id"": ""RHEA:11309"", ""source_assertion"": ""Rhea places CHEBI:43474 on the products side of directed RHEA:11309, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/11309/rh:products; http://rdf.rhea-db.org/11308_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_11308_compound_5518/rh:compound -> http://rdf.rhea-db.org/Compound_5518/rh:chebi""}]"	"[{""id"": ""RHEA:11309"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 11309 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-011_46425b6ebedc	RHEA:11309	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11309		"[{""reference_id"": ""RHEA:11309"", ""source_assertion"": ""Rhea places CHEBI:15378 on the products side of directed RHEA:11309, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/11309/rh:products; http://rdf.rhea-db.org/11308_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_11308_compound_3249/rh:compound -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:11309"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 11309 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-012_9ce0b9c6bf0b	CHEBI:57384	pathwaymech:consumes	RHEA:26448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448		"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea places CHEBI:57384 on the substrates side of directed RHEA:26448, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448/rh:substrates; http://rdf.rhea-db.org/26446_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26446_compound_5125/rh:compound -> http://rdf.rhea-db.org/Compound_5125/rh:chebi""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26448 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-013_3af580f435fd	CHEBI:57783	pathwaymech:consumes	RHEA:26448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448		"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea places CHEBI:57783 on the substrates side of directed RHEA:26448, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448/rh:substrates; http://rdf.rhea-db.org/26446_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26446_compound_3438/rh:compound -> http://rdf.rhea-db.org/Compound_3438/rh:chebi""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26448 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-014_364f90c82db3	CHEBI:15378	pathwaymech:consumes	RHEA:26448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448		"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea places CHEBI:15378 on the substrates side of directed RHEA:26448, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448/rh:substrates; http://rdf.rhea-db.org/26446_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26446_compound_3249/rh:compound -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26448 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-015_4adac0f29da3	RHEA:26448	pathwaymech:produces	CHEBI:33190	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448		"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea places CHEBI:33190 on the products side of directed RHEA:26448, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448/rh:products; http://rdf.rhea-db.org/26446_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26446_compound_5274/rh:compound -> http://rdf.rhea-db.org/Compound_5274/rh:chebi""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26448 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-016_86ecc1c5dc5c	RHEA:26448	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448		"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea places CHEBI:58349 on the products side of directed RHEA:26448, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448/rh:products; http://rdf.rhea-db.org/26446_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26446_compound_5188/rh:compound -> http://rdf.rhea-db.org/Compound_5188/rh:chebi""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26448 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-017_38c8f98bbda1	RHEA:26448	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26448		"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""Rhea places CHEBI:57287 on the products side of directed RHEA:26448, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448/rh:products; http://rdf.rhea-db.org/26446_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26446_compound_1264/rh:compound -> http://rdf.rhea-db.org/Compound_1264/rh:chebi""}]"	"[{""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26448 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-018_855011b8c0b1	CHEBI:33190	pathwaymech:consumes	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440		"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea places CHEBI:33190 on the substrates side of directed RHEA:26440, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440/rh:substrates; http://rdf.rhea-db.org/26438_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26438_compound_5274/rh:compound -> http://rdf.rhea-db.org/Compound_5274/rh:chebi""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26440 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-019_3fb5e6db4212	CHEBI:57783	pathwaymech:consumes	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440		"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea places CHEBI:57783 on the substrates side of directed RHEA:26440, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440/rh:substrates; http://rdf.rhea-db.org/26438_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26438_compound_3438/rh:compound -> http://rdf.rhea-db.org/Compound_3438/rh:chebi""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26440 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-020_88b8074dc1f6	CHEBI:15378	pathwaymech:consumes	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440		"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea places CHEBI:15378 on the substrates side of directed RHEA:26440, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440/rh:substrates; http://rdf.rhea-db.org/26438_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26438_compound_3249/rh:compound -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26440 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-021_0df4eee28f2d	RHEA:26440	pathwaymech:produces	CHEBI:16510	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440		"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea places CHEBI:16510 on the products side of directed RHEA:26440, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440/rh:products; http://rdf.rhea-db.org/26438_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26438_compound_3378/rh:compound -> http://rdf.rhea-db.org/Compound_3378/rh:chebi""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26440 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-022_efe24864a4e5	RHEA:26440	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440		"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea places CHEBI:58349 on the products side of directed RHEA:26440, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440/rh:products; http://rdf.rhea-db.org/26438_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26438_compound_5188/rh:compound -> http://rdf.rhea-db.org/Compound_5188/rh:chebi""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26440 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-023_ec3fa0f48f13	CHEBI:16510	pathwaymech:consumes	RHEA:26535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26535		"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea places CHEBI:16510 on the substrates side of directed RHEA:26535, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535/rh:substrates; http://rdf.rhea-db.org/26534_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26534_compound_3378/rh:compound -> http://rdf.rhea-db.org/Compound_3378/rh:chebi""}]"	"[{""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26535 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-024_3bfca139dc84	CHEBI:30616	pathwaymech:consumes	RHEA:26535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26535		"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea places CHEBI:30616 on the substrates side of directed RHEA:26535, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535/rh:substrates; http://rdf.rhea-db.org/26534_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26534_compound_6372/rh:compound -> http://rdf.rhea-db.org/Compound_6372/rh:chebi""}]"	"[{""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26535 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-025_e543a54c379e	CHEBI:57287	pathwaymech:consumes	RHEA:26535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26535		"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea places CHEBI:57287 on the substrates side of directed RHEA:26535, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535/rh:substrates; http://rdf.rhea-db.org/26534_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26534_compound_1264/rh:compound -> http://rdf.rhea-db.org/Compound_1264/rh:chebi""}]"	"[{""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26535 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-026_eb6a51aed9c7	RHEA:26535	pathwaymech:produces	CHEBI:58528	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26535		"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea places CHEBI:58528 on the products side of directed RHEA:26535, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535/rh:products; http://rdf.rhea-db.org/26534_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26534_compound_6030/rh:compound -> http://rdf.rhea-db.org/Compound_6030/rh:chebi""}]"	"[{""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26535 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-027_0fa318bcc34f	RHEA:26535	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26535		"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea places CHEBI:456215 on the products side of directed RHEA:26535, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535/rh:products; http://rdf.rhea-db.org/26534_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26534_compound_2590/rh:compound -> http://rdf.rhea-db.org/Compound_2590/rh:chebi""}]"	"[{""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26535 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-028_0e03f9c8506b	RHEA:26535	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26535		"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""Rhea places CHEBI:33019 on the products side of directed RHEA:26535, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535/rh:products; http://rdf.rhea-db.org/26534_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26534_compound_2106/rh:compound -> http://rdf.rhea-db.org/Compound_2106/rh:chebi""}]"	"[{""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26535 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-029_43ffc79e9f33	CHEBI:58528	pathwaymech:consumes	RHEA:26519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26519		"[{""reference_id"": ""RHEA:26519"", ""source_assertion"": ""Rhea places CHEBI:58528 on the substrates side of directed RHEA:26519, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26519/rh:substrates; http://rdf.rhea-db.org/26518_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26518_compound_6030/rh:compound -> http://rdf.rhea-db.org/Compound_6030/rh:chebi""}]"	"[{""id"": ""RHEA:26519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26519 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-030_f4c1b5f32bc6	RHEA:26519	pathwaymech:produces	CHEBI:57367	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26519		"[{""reference_id"": ""RHEA:26519"", ""source_assertion"": ""Rhea places CHEBI:57367 on the products side of directed RHEA:26519, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26519/rh:products; http://rdf.rhea-db.org/26518_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26518_compound_2006/rh:compound -> http://rdf.rhea-db.org/Compound_2006/rh:chebi""}]"	"[{""id"": ""RHEA:26519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26519 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-031_17b3cef44c54	RHEA:26519	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26519		"[{""reference_id"": ""RHEA:26519"", ""source_assertion"": ""Rhea places CHEBI:15377 on the products side of directed RHEA:26519, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26519/rh:products; http://rdf.rhea-db.org/26518_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26518_compound_1283/rh:compound -> http://rdf.rhea-db.org/Compound_1283/rh:chebi""}]"	"[{""id"": ""RHEA:26519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26519 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-032_88c47c07bf08	CHEBI:57367	pathwaymech:consumes	RHEA:26456	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456		"[{""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea places CHEBI:57367 on the substrates side of directed RHEA:26456, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456/rh:substrates; http://rdf.rhea-db.org/26454_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26454_compound_2006/rh:compound -> http://rdf.rhea-db.org/Compound_2006/rh:chebi""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26456 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-033_e4f1dfdbd11f	CHEBI:57783	pathwaymech:consumes	RHEA:26456	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456		"[{""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea places CHEBI:57783 on the substrates side of directed RHEA:26456, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456/rh:substrates; http://rdf.rhea-db.org/26454_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26454_compound_3438/rh:compound -> http://rdf.rhea-db.org/Compound_3438/rh:chebi""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26456 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-034_c56c0f92f807	CHEBI:15378	pathwaymech:consumes	RHEA:26456	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456		"[{""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea places CHEBI:15378 on the substrates side of directed RHEA:26456, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456/rh:substrates; http://rdf.rhea-db.org/26454_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26454_compound_3249/rh:compound -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26456 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-035_f4ed82541bca	RHEA:26456	pathwaymech:produces	CHEBI:57392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456		"[{""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea places CHEBI:57392 on the products side of directed RHEA:26456, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456/rh:products; http://rdf.rhea-db.org/26454_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26454_compound_3421/rh:compound -> http://rdf.rhea-db.org/Compound_3421/rh:chebi""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26456 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-036_2587ca542f52	RHEA:26456	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456		"[{""reference_id"": ""RHEA:26456"", ""source_assertion"": ""Rhea places CHEBI:58349 on the products side of directed RHEA:26456, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456/rh:products; http://rdf.rhea-db.org/26454_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26454_compound_5188/rh:compound -> http://rdf.rhea-db.org/Compound_5188/rh:chebi""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26456 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-037_07c1fb80de87	CHEBI:57392	pathwaymech:consumes	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721		"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Rhea places CHEBI:57392 on the substrates side of directed RHEA:23721, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23721/rh:substrates; http://rdf.rhea-db.org/23720_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_23720_compound_3421/rh:compound -> http://rdf.rhea-db.org/Compound_3421/rh:chebi""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23721 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-038_4d8e0b792885	CHEBI:17544	pathwaymech:consumes	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721		"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Rhea places CHEBI:17544 on the substrates side of directed RHEA:23721, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23721/rh:substrates; http://rdf.rhea-db.org/23720_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_23720_compound_1123/rh:compound -> http://rdf.rhea-db.org/Compound_1123/rh:chebi""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23721 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-039_24e0d95382ea	CHEBI:30616	pathwaymech:consumes	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721		"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Rhea places CHEBI:30616 on the substrates side of directed RHEA:23721, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23721/rh:substrates; http://rdf.rhea-db.org/23720_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_23720_compound_6372/rh:compound -> http://rdf.rhea-db.org/Compound_6372/rh:chebi""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23721 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-040_03d8472f9881	RHEA:23721	pathwaymech:produces	CHEBI:57327	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721		"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Rhea places CHEBI:57327 on the products side of directed RHEA:23721, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23721/rh:products; http://rdf.rhea-db.org/23720_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_23720_compound_2780/rh:compound -> http://rdf.rhea-db.org/Compound_2780/rh:chebi""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23721 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-041_f3083842d27c	RHEA:23721	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721		"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Rhea places CHEBI:456216 on the products side of directed RHEA:23721, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23721/rh:products; http://rdf.rhea-db.org/23720_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_23720_compound_2710/rh:compound -> http://rdf.rhea-db.org/Compound_2710/rh:chebi""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23721 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-042_d2f651b9ccc3	RHEA:23721	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721		"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Rhea places CHEBI:43474 on the products side of directed RHEA:23721, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23721/rh:products; http://rdf.rhea-db.org/23720_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_23720_compound_5518/rh:compound -> http://rdf.rhea-db.org/Compound_5518/rh:chebi""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23721 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-043_0ec111bedbb7	RHEA:23721	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721		"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""Rhea places CHEBI:15378 on the products side of directed RHEA:23721, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23721/rh:products; http://rdf.rhea-db.org/23720_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_23720_compound_3249/rh:compound -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23721 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-044_df3e8714d5ec	CHEBI:57327	pathwaymech:consumes	RHEA:20555	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20555		"[{""reference_id"": ""RHEA:20555"", ""source_assertion"": ""Rhea places CHEBI:57327 on the substrates side of directed RHEA:20555, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/20555/rh:substrates; http://rdf.rhea-db.org/20553_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_20553_compound_2780/rh:compound -> http://rdf.rhea-db.org/Compound_2780/rh:chebi""}]"	"[{""id"": ""RHEA:20555"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 20555 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-045_876e23f16551	RHEA:20555	pathwaymech:produces	CHEBI:57326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20555		"[{""reference_id"": ""RHEA:20555"", ""source_assertion"": ""Rhea places CHEBI:57326 on the products side of directed RHEA:20555, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/20555/rh:products; http://rdf.rhea-db.org/20553_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_20553_compound_1391/rh:compound -> http://rdf.rhea-db.org/Compound_1391/rh:chebi""}]"	"[{""id"": ""RHEA:20555"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 20555 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-046_fc25ebe40c3f	CHEBI:57326	pathwaymech:consumes	RHEA:22889	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22889		"[{""reference_id"": ""RHEA:22889"", ""source_assertion"": ""Rhea places CHEBI:57326 on the substrates side of directed RHEA:22889, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22889/rh:substrates; http://rdf.rhea-db.org/22888_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_22888_compound_1391/rh:compound -> http://rdf.rhea-db.org/Compound_1391/rh:chebi""}]"	"[{""id"": ""RHEA:22889"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 22889 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-047_d9fa8a68b7d2	RHEA:22889	pathwaymech:produces	CHEBI:57292	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22889		"[{""reference_id"": ""RHEA:22889"", ""source_assertion"": ""Rhea places CHEBI:57292 on the products side of directed RHEA:22889, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22889/rh:products; http://rdf.rhea-db.org/22888_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_22888_compound_4684/rh:compound -> http://rdf.rhea-db.org/Compound_4684/rh:chebi""}]"	"[{""id"": ""RHEA:22889"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 22889 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-048_e1202aac9bd8	CHEBI:57292	pathwaymech:consumes	RHEA:26452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26452		"[{""reference_id"": ""RHEA:26452"", ""source_assertion"": ""Rhea places CHEBI:57292 on the substrates side of directed RHEA:26452, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26452/rh:substrates; http://rdf.rhea-db.org/26450_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26450_compound_4684/rh:compound -> http://rdf.rhea-db.org/Compound_4684/rh:chebi""}]"	"[{""id"": ""RHEA:26452"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26452 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-049_a9c82645b96b	CHEBI:57783	pathwaymech:consumes	RHEA:26452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26452		"[{""reference_id"": ""RHEA:26452"", ""source_assertion"": ""Rhea places CHEBI:57783 on the substrates side of directed RHEA:26452, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26452/rh:substrates; http://rdf.rhea-db.org/26450_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26450_compound_3438/rh:compound -> http://rdf.rhea-db.org/Compound_3438/rh:chebi""}]"	"[{""id"": ""RHEA:26452"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26452 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-050_ea091a84ca26	CHEBI:15378	pathwaymech:consumes	RHEA:26452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26452		"[{""reference_id"": ""RHEA:26452"", ""source_assertion"": ""Rhea places CHEBI:15378 on the substrates side of directed RHEA:26452, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26452/rh:substrates; http://rdf.rhea-db.org/26450_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26450_compound_3249/rh:compound -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:26452"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26452 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-051_78084ea7b729	RHEA:26452	pathwaymech:produces	CHEBI:57706	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26452		"[{""reference_id"": ""RHEA:26452"", ""source_assertion"": ""Rhea places CHEBI:57706 on the products side of directed RHEA:26452, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26452/rh:products; http://rdf.rhea-db.org/26450_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26450_compound_4279/rh:compound -> http://rdf.rhea-db.org/Compound_4279/rh:chebi""}]"	"[{""id"": ""RHEA:26452"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26452 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-052_cea07e5ebe45	RHEA:26452	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26452		"[{""reference_id"": ""RHEA:26452"", ""source_assertion"": ""Rhea places CHEBI:58349 on the products side of directed RHEA:26452, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26452/rh:products; http://rdf.rhea-db.org/26450_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26450_compound_5188/rh:compound -> http://rdf.rhea-db.org/Compound_5188/rh:chebi""}]"	"[{""id"": ""RHEA:26452"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26452 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-053_da698b6027eb	RHEA:26452	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26452		"[{""reference_id"": ""RHEA:26452"", ""source_assertion"": ""Rhea places CHEBI:57287 on the products side of directed RHEA:26452, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26452/rh:products; http://rdf.rhea-db.org/26450_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26450_compound_1264/rh:compound -> http://rdf.rhea-db.org/Compound_1264/rh:chebi""}]"	"[{""id"": ""RHEA:26452"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26452 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-054_ec0dfb0c1fa2	CHEBI:57706	pathwaymech:consumes	RHEA:26383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26383		"[{""reference_id"": ""RHEA:26383"", ""source_assertion"": ""Rhea places CHEBI:57706 on the substrates side of directed RHEA:26383, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26383/rh:substrates; http://rdf.rhea-db.org/26381_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26381_compound_4279/rh:compound -> http://rdf.rhea-db.org/Compound_4279/rh:chebi""}]"	"[{""id"": ""RHEA:26383"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26383 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-055_b2c36ddcb345	CHEBI:57783	pathwaymech:consumes	RHEA:26383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26383		"[{""reference_id"": ""RHEA:26383"", ""source_assertion"": ""Rhea places CHEBI:57783 on the substrates side of directed RHEA:26383, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26383/rh:substrates; http://rdf.rhea-db.org/26381_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26381_compound_3438/rh:compound -> http://rdf.rhea-db.org/Compound_3438/rh:chebi""}]"	"[{""id"": ""RHEA:26383"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26383 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-056_90eef356d1f8	CHEBI:15378	pathwaymech:consumes	RHEA:26383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26383		"[{""reference_id"": ""RHEA:26383"", ""source_assertion"": ""Rhea places CHEBI:15378 on the substrates side of directed RHEA:26383, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26383/rh:substrates; http://rdf.rhea-db.org/26381_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26381_compound_3249/rh:compound -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:26383"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26383 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-057_1a6fd1020039	RHEA:26383	pathwaymech:produces	CHEBI:16724	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26383		"[{""reference_id"": ""RHEA:26383"", ""source_assertion"": ""Rhea places CHEBI:16724 on the products side of directed RHEA:26383, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26383/rh:products; http://rdf.rhea-db.org/26381_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26381_compound_5278/rh:compound -> http://rdf.rhea-db.org/Compound_5278/rh:chebi""}]"	"[{""id"": ""RHEA:26383"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26383 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-058_72b911a2390e	RHEA:26383	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26383		"[{""reference_id"": ""RHEA:26383"", ""source_assertion"": ""Rhea places CHEBI:58349 on the products side of directed RHEA:26383, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26383/rh:products; http://rdf.rhea-db.org/26381_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26381_compound_5188/rh:compound -> http://rdf.rhea-db.org/Compound_5188/rh:chebi""}]"	"[{""id"": ""RHEA:26383"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26383 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-059_903025b2de4a	CHEBI:16724	pathwaymech:consumes	RHEA:23129	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23129		"[{""reference_id"": ""RHEA:23129"", ""source_assertion"": ""Rhea places CHEBI:16724 on the substrates side of directed RHEA:23129, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23129/rh:substrates; http://rdf.rhea-db.org/23128_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_23128_compound_5278/rh:compound -> http://rdf.rhea-db.org/Compound_5278/rh:chebi""}]"	"[{""id"": ""RHEA:23129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23129 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-060_62a7735be582	CHEBI:30616	pathwaymech:consumes	RHEA:23129	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23129		"[{""reference_id"": ""RHEA:23129"", ""source_assertion"": ""Rhea places CHEBI:30616 on the substrates side of directed RHEA:23129, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23129/rh:substrates; http://rdf.rhea-db.org/23128_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_23128_compound_6372/rh:compound -> http://rdf.rhea-db.org/Compound_6372/rh:chebi""}]"	"[{""id"": ""RHEA:23129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23129 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-061_f3392e231123	CHEBI:57287	pathwaymech:consumes	RHEA:23129	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23129		"[{""reference_id"": ""RHEA:23129"", ""source_assertion"": ""Rhea places CHEBI:57287 on the substrates side of directed RHEA:23129, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23129/rh:substrates; http://rdf.rhea-db.org/23128_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_23128_compound_1264/rh:compound -> http://rdf.rhea-db.org/Compound_1264/rh:chebi""}]"	"[{""id"": ""RHEA:23129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23129 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-062_6eba79c5f0c4	RHEA:23129	pathwaymech:produces	CHEBI:58574	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23129		"[{""reference_id"": ""RHEA:23129"", ""source_assertion"": ""Rhea places CHEBI:58574 on the products side of directed RHEA:23129, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23129/rh:products; http://rdf.rhea-db.org/23128_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_23128_compound_6032/rh:compound -> http://rdf.rhea-db.org/Compound_6032/rh:chebi""}]"	"[{""id"": ""RHEA:23129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23129 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-063_9be35bea309f	RHEA:23129	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23129		"[{""reference_id"": ""RHEA:23129"", ""source_assertion"": ""Rhea places CHEBI:456215 on the products side of directed RHEA:23129, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23129/rh:products; http://rdf.rhea-db.org/23128_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_23128_compound_2590/rh:compound -> http://rdf.rhea-db.org/Compound_2590/rh:chebi""}]"	"[{""id"": ""RHEA:23129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23129 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-064_abebf8b89a06	RHEA:23129	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23129		"[{""reference_id"": ""RHEA:23129"", ""source_assertion"": ""Rhea places CHEBI:33019 on the products side of directed RHEA:23129, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23129/rh:products; http://rdf.rhea-db.org/23128_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_23128_compound_2106/rh:compound -> http://rdf.rhea-db.org/Compound_2106/rh:chebi""}]"	"[{""id"": ""RHEA:23129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23129 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-065_54e811a2e381	CHEBI:58574	pathwaymech:consumes	RHEA:26531	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26531		"[{""reference_id"": ""RHEA:26531"", ""source_assertion"": ""Rhea places CHEBI:58574 on the substrates side of directed RHEA:26531, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26531/rh:substrates; http://rdf.rhea-db.org/26530_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26530_compound_6032/rh:compound -> http://rdf.rhea-db.org/Compound_6032/rh:chebi""}]"	"[{""id"": ""RHEA:26531"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26531 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-066_f5bc00f506b5	RHEA:26531	pathwaymech:produces	CHEBI:57332	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26531		"[{""reference_id"": ""RHEA:26531"", ""source_assertion"": ""Rhea places CHEBI:57332 on the products side of directed RHEA:26531, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26531/rh:products; http://rdf.rhea-db.org/26530_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26530_compound_2633/rh:compound -> http://rdf.rhea-db.org/Compound_2633/rh:chebi""}]"	"[{""id"": ""RHEA:26531"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26531 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-067_96aa904d416c	RHEA:26531	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26531		"[{""reference_id"": ""RHEA:26531"", ""source_assertion"": ""Rhea places CHEBI:15377 on the products side of directed RHEA:26531, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26531/rh:products; http://rdf.rhea-db.org/26530_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26530_compound_1283/rh:compound -> http://rdf.rhea-db.org/Compound_1283/rh:chebi""}]"	"[{""id"": ""RHEA:26531"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26531 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-068_5536591337e6	CHEBI:57332	pathwaymech:consumes	RHEA:26560	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26560		"[{""reference_id"": ""RHEA:26560"", ""source_assertion"": ""Rhea places CHEBI:57332 on the substrates side of directed RHEA:26560, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26560/rh:substrates; http://rdf.rhea-db.org/26558_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26558_compound_2633/rh:compound -> http://rdf.rhea-db.org/Compound_2633/rh:chebi""}]"	"[{""id"": ""RHEA:26560"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26560 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-069_2bfe35abb1ad	CHEBI:15377	pathwaymech:consumes	RHEA:26560	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26560		"[{""reference_id"": ""RHEA:26560"", ""source_assertion"": ""Rhea places CHEBI:15377 on the substrates side of directed RHEA:26560, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26560/rh:substrates; http://rdf.rhea-db.org/26558_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26558_compound_1283/rh:compound -> http://rdf.rhea-db.org/Compound_1283/rh:chebi""}]"	"[{""id"": ""RHEA:26560"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26560 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-070_07ea72085ed9	RHEA:26560	pathwaymech:produces	CHEBI:57316	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26560		"[{""reference_id"": ""RHEA:26560"", ""source_assertion"": ""Rhea places CHEBI:57316 on the products side of directed RHEA:26560, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26560/rh:products; http://rdf.rhea-db.org/26558_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26558_compound_2192/rh:compound -> http://rdf.rhea-db.org/Compound_2192/rh:chebi""}]"	"[{""id"": ""RHEA:26560"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26560 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-071_8cd4f1f75969	CHEBI:57316	pathwaymech:consumes	RHEA:30800	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30800		"[{""reference_id"": ""RHEA:30800"", ""source_assertion"": ""Rhea places CHEBI:57316 on the substrates side of directed RHEA:30800, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30800/rh:substrates; http://rdf.rhea-db.org/30799_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_30799_compound_2192/rh:compound -> http://rdf.rhea-db.org/Compound_2192/rh:chebi""}]"	"[{""id"": ""RHEA:30800"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 30800 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-072_2f93c0e8c45a	CHEBI:57540	pathwaymech:consumes	RHEA:30800	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30800		"[{""reference_id"": ""RHEA:30800"", ""source_assertion"": ""Rhea places CHEBI:57540 on the substrates side of directed RHEA:30800, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30800/rh:substrates; http://rdf.rhea-db.org/30799_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_30799_compound_3484/rh:compound -> http://rdf.rhea-db.org/Compound_3484/rh:chebi""}]"	"[{""id"": ""RHEA:30800"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 30800 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-073_863898c6ea0c	RHEA:30800	pathwaymech:produces	CHEBI:57286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30800		"[{""reference_id"": ""RHEA:30800"", ""source_assertion"": ""Rhea places CHEBI:57286 on the products side of directed RHEA:30800, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30800/rh:products; http://rdf.rhea-db.org/30799_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_30799_compound_4872/rh:compound -> http://rdf.rhea-db.org/Compound_4872/rh:chebi""}]"	"[{""id"": ""RHEA:30800"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 30800 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-074_dca04aa73657	RHEA:30800	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30800		"[{""reference_id"": ""RHEA:30800"", ""source_assertion"": ""Rhea places CHEBI:57945 on the products side of directed RHEA:30800, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30800/rh:products; http://rdf.rhea-db.org/30799_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_30799_compound_1650/rh:compound -> http://rdf.rhea-db.org/Compound_1650/rh:chebi""}]"	"[{""id"": ""RHEA:30800"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 30800 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-075_2be693cab301	RHEA:30800	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30800		"[{""reference_id"": ""RHEA:30800"", ""source_assertion"": ""Rhea places CHEBI:15378 on the products side of directed RHEA:30800, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30800/rh:products; http://rdf.rhea-db.org/30799_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_30799_compound_3249/rh:compound -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:30800"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 30800 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-076_87d5dc8eafd9	CHEBI:57286	pathwaymech:consumes	RHEA:21038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21038		"[{""reference_id"": ""RHEA:21038"", ""source_assertion"": ""Rhea places CHEBI:57286 on the substrates side of directed RHEA:21038, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/21038/rh:substrates; http://rdf.rhea-db.org/21036_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_21036_compound_4872/rh:compound -> http://rdf.rhea-db.org/Compound_4872/rh:chebi""}]"	"[{""id"": ""RHEA:21038"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 21038 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-077_d420d2da2b46	CHEBI:57287	pathwaymech:consumes	RHEA:21038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21038		"[{""reference_id"": ""RHEA:21038"", ""source_assertion"": ""Rhea places CHEBI:57287 on the substrates side of directed RHEA:21038, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/21038/rh:substrates; http://rdf.rhea-db.org/21036_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_21036_compound_1264/rh:compound -> http://rdf.rhea-db.org/Compound_1264/rh:chebi""}]"	"[{""id"": ""RHEA:21038"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 21038 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-078_c2f7b3de2c68	RHEA:21038	pathwaymech:produces	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21038		"[{""reference_id"": ""RHEA:21038"", ""source_assertion"": ""Rhea places CHEBI:57288 on the products side of directed RHEA:21038, with coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/21038/rh:products; http://rdf.rhea-db.org/21036_L/rh:contains2 -> http://rdf.rhea-db.org/Participant_21036_compound_4271/rh:compound -> http://rdf.rhea-db.org/Compound_4271/rh:chebi""}]"	"[{""id"": ""RHEA:21038"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 21038 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-079_d78e8d3cb1dc	RHEA:10750	BFO:0000050	MetaCyc:PWY-5789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5789|MetaCyc:RXN0-5224|RHEA:10750	Auxiliary CO2 hydration supplies bicarbonate. The formal reaction is retained without a molecular-activity category or an unsupported enzyme assignment.	"[{""reference_id"": ""MetaCyc:PWY-5789"", ""source_assertion"": ""PWY-5789 explicitly contains RXN0-5224 in its native reaction list and layout."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list; /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:RXN0-5224"", ""source_assertion"": ""The native reaction cross-references Rhea 10751. Its native pathway direction is retained through the selected current directed member."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]; /ptools-xml/Reaction/left; /ptools-xml/Reaction/right""}, {""reference_id"": ""RHEA:10750"", ""source_assertion"": ""The native cross-reference and selected directed reaction belong to the same original Rhea reaction family; current Rhea supplies explicit charged chemical forms and side coefficients."", ""source_locator"": ""http://rdf.rhea-db.org/10748/rh:bidirectionalReaction -> http://rdf.rhea-db.org/10751; http://rdf.rhea-db.org/10748/rh:directionalReaction -> http://rdf.rhea-db.org/10750""}]"	"[{""id"": ""MetaCyc:PWY-5789"", ""source_sha256"": ""134f07865db2c2e86fcddf093a2e1cc1188f91a6a1f54a004d328efa52c5ab54"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc PWY-5789 full native pathway XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5789""}, {""id"": ""MetaCyc:RXN0-5224"", ""source_sha256"": ""0f8ea48758c659d86a3f3fb429d73ee60560ab80646e4233481caa7e4cf3ffb5"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN0-5224 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5224""}, {""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 10750 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-080_959558d670ec	RHEA:11309	BFO:0000050	MetaCyc:PWY-5789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN-CARBOXYL-RXN|MetaCyc:PWY-5789|MetaCyc:RXN0-5055|RHEA:11309	The two native biotin half-reactions are represented once by their independently issued net equation. This preserves the measured archaeal holoenzyme without asserting the bacterial BCCP-dimer carrier identity or counting the same turnover twice.	"[{""reference_id"": ""MetaCyc:PWY-5789"", ""source_assertion"": ""PWY-5789 explicitly contains BIOTIN-CARBOXYL-RXN, RXN0-5055 in its native reaction list and layout."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list; /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:BIOTIN-CARBOXYL-RXN"", ""source_assertion"": ""The native carboxylase half-reaction retains its biotinylated protein carrier, ATP/proton bookkeeping and carbon substrate."", ""source_locator"": ""/ptools-xml/Reaction/left; /ptools-xml/Reaction/right""}, {""reference_id"": ""MetaCyc:RXN0-5055"", ""source_assertion"": ""The native carboxylase half-reaction retains its biotinylated protein carrier, ATP/proton bookkeeping and carbon substrate."", ""source_locator"": ""/ptools-xml/Reaction/left; /ptools-xml/Reaction/right""}, {""reference_id"": ""RHEA:11309"", ""source_assertion"": ""Rhea independently issues the complete acetyl-CoA carboxylase net equation; the identical native uncarboxylated/carboxylated carrier states cancel when the two native half-reactions are added."", ""source_locator"": ""http://rdf.rhea-db.org/11309/rh:equation; http://rdf.rhea-db.org/11308/rh:directionalReaction -> http://rdf.rhea-db.org/11309""}]"	"[{""id"": ""MetaCyc:BIOTIN-CARBOXYL-RXN"", ""source_sha256"": ""85d21badd44d87a38c810e80b4ee276f91cf66fbe2d1995103ffdbb77ec3728b"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc BIOTIN-CARBOXYL-RXN native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN-CARBOXYL-RXN""}, {""id"": ""MetaCyc:PWY-5789"", ""source_sha256"": ""134f07865db2c2e86fcddf093a2e1cc1188f91a6a1f54a004d328efa52c5ab54"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc PWY-5789 full native pathway XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5789""}, {""id"": ""MetaCyc:RXN0-5055"", ""source_sha256"": ""7962754112f02260c380c8ee7e5807bf4333ec5c2325852071e114c4884176ed"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN0-5055 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5055""}, {""id"": ""RHEA:11309"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 11309 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-081_7697e15e064b	RHEA:26448	BFO:0000050	MetaCyc:PWY-5789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5789|MetaCyc:RXN-8963|RHEA:26448		"[{""reference_id"": ""MetaCyc:PWY-5789"", ""source_assertion"": ""PWY-5789 explicitly contains RXN-8963 in its native reaction list and layout."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list; /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:RXN-8963"", ""source_assertion"": ""The native reaction cross-references Rhea 26449. Its native pathway direction is retained through the selected current directed member."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]; /ptools-xml/Reaction/left; /ptools-xml/Reaction/right""}, {""reference_id"": ""RHEA:26448"", ""source_assertion"": ""The native cross-reference and selected directed reaction belong to the same original Rhea reaction family; current Rhea supplies explicit charged chemical forms and side coefficients."", ""source_locator"": ""http://rdf.rhea-db.org/26446/rh:directionalReaction -> http://rdf.rhea-db.org/26448; http://rdf.rhea-db.org/26446/rh:bidirectionalReaction -> http://rdf.rhea-db.org/26449""}]"	"[{""id"": ""MetaCyc:PWY-5789"", ""source_sha256"": ""134f07865db2c2e86fcddf093a2e1cc1188f91a6a1f54a004d328efa52c5ab54"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc PWY-5789 full native pathway XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5789""}, {""id"": ""MetaCyc:RXN-8963"", ""source_sha256"": ""f0e6b1ac76f3081d1701c4504a9b47a32dd6b325539447e0148ffc48cacaa154"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN-8963 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8963""}, {""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26448 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-082_3237d6ca969b	RHEA:26440	BFO:0000050	MetaCyc:PWY-5789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5789|MetaCyc:RXN-8974|RHEA:26440		"[{""reference_id"": ""MetaCyc:PWY-5789"", ""source_assertion"": ""PWY-5789 explicitly contains RXN-8974 in its native reaction list and layout."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list; /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:RXN-8974"", ""source_assertion"": ""The native reaction cross-references Rhea 26440. Its native pathway direction is retained through the selected current directed member."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]; /ptools-xml/Reaction/left; /ptools-xml/Reaction/right""}, {""reference_id"": ""RHEA:26440"", ""source_assertion"": ""The native cross-reference and selected directed reaction belong to the same original Rhea reaction family; current Rhea supplies explicit charged chemical forms and side coefficients."", ""source_locator"": ""http://rdf.rhea-db.org/26438/rh:directionalReaction -> http://rdf.rhea-db.org/26440""}]"	"[{""id"": ""MetaCyc:PWY-5789"", ""source_sha256"": ""134f07865db2c2e86fcddf093a2e1cc1188f91a6a1f54a004d328efa52c5ab54"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc PWY-5789 full native pathway XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5789""}, {""id"": ""MetaCyc:RXN-8974"", ""source_sha256"": ""ddb5c15214b2047cc5aeae0076f7fc8783861858b628c566363887a83208a824"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN-8974 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8974""}, {""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26440 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-083_135915cc03a2	RHEA:26535	BFO:0000050	MetaCyc:PWY-5789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5789|MetaCyc:RXN-9086|RHEA:26535		"[{""reference_id"": ""MetaCyc:PWY-5789"", ""source_assertion"": ""PWY-5789 explicitly contains RXN-9086 in its native reaction list and layout."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list; /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:RXN-9086"", ""source_assertion"": ""The native reaction cross-references Rhea 26535. Its native pathway direction is retained through the selected current directed member."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]; /ptools-xml/Reaction/left; /ptools-xml/Reaction/right""}, {""reference_id"": ""RHEA:26535"", ""source_assertion"": ""The native cross-reference and selected directed reaction belong to the same original Rhea reaction family; current Rhea supplies explicit charged chemical forms and side coefficients."", ""source_locator"": ""http://rdf.rhea-db.org/26534/rh:directionalReaction -> http://rdf.rhea-db.org/26535""}]"	"[{""id"": ""MetaCyc:PWY-5789"", ""source_sha256"": ""134f07865db2c2e86fcddf093a2e1cc1188f91a6a1f54a004d328efa52c5ab54"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc PWY-5789 full native pathway XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5789""}, {""id"": ""MetaCyc:RXN-9086"", ""source_sha256"": ""b5cfb7a4cae84f5203e562f4a58aa6fc02b3af5532953d0d7249745499f2c791"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN-9086 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9086""}, {""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26535 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-084_8353d32b21f1	RHEA:26519	BFO:0000050	MetaCyc:PWY-5789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5789|MetaCyc:RXN-6383|RHEA:26519		"[{""reference_id"": ""MetaCyc:PWY-5789"", ""source_assertion"": ""PWY-5789 explicitly contains RXN-6383 in its native reaction list and layout."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list; /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:RXN-6383"", ""source_assertion"": ""The native reaction cross-references Rhea 26518. Its native pathway direction is retained through the selected current directed member."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]; /ptools-xml/Reaction/left; /ptools-xml/Reaction/right""}, {""reference_id"": ""RHEA:26519"", ""source_assertion"": ""The native cross-reference and selected directed reaction belong to the same original Rhea reaction family; current Rhea supplies explicit charged chemical forms and side coefficients."", ""source_locator"": ""http://rdf.rhea-db.org/26518/rh:directionalReaction -> http://rdf.rhea-db.org/26519; http://rdf.rhea-db.org/26518/rh:id""}]"	"[{""id"": ""MetaCyc:PWY-5789"", ""source_sha256"": ""134f07865db2c2e86fcddf093a2e1cc1188f91a6a1f54a004d328efa52c5ab54"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc PWY-5789 full native pathway XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5789""}, {""id"": ""MetaCyc:RXN-6383"", ""source_sha256"": ""ca3f42be810f2d950159b350849efcc45a3d5299c860b1e7398b13370878f5fe"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN-6383 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-6383""}, {""id"": ""RHEA:26519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26519 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-085_b11c1386903b	RHEA:26456	BFO:0000050	MetaCyc:PWY-5789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5789|MetaCyc:RXN-9087|RHEA:26456		"[{""reference_id"": ""MetaCyc:PWY-5789"", ""source_assertion"": ""PWY-5789 explicitly contains RXN-9087 in its native reaction list and layout."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list; /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:RXN-9087"", ""source_assertion"": ""The native reaction cross-references Rhea 26456. Its native pathway direction is retained through the selected current directed member."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]; /ptools-xml/Reaction/left; /ptools-xml/Reaction/right""}, {""reference_id"": ""RHEA:26456"", ""source_assertion"": ""The native cross-reference and selected directed reaction belong to the same original Rhea reaction family; current Rhea supplies explicit charged chemical forms and side coefficients."", ""source_locator"": ""http://rdf.rhea-db.org/26454/rh:directionalReaction -> http://rdf.rhea-db.org/26456""}]"	"[{""id"": ""MetaCyc:PWY-5789"", ""source_sha256"": ""134f07865db2c2e86fcddf093a2e1cc1188f91a6a1f54a004d328efa52c5ab54"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc PWY-5789 full native pathway XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5789""}, {""id"": ""MetaCyc:RXN-9087"", ""source_sha256"": ""1f715ecd994c074e00fe02f4fbbbc58cea6f090ef85eb54516687984683f3b70"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN-9087 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9087""}, {""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26456 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-086_c9e2850b9fd0	RHEA:23721	BFO:0000050	MetaCyc:PWY-5789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PROPIONYL-COA-CARBOXY-RXN|MetaCyc:PWY-5789|RHEA:23721		"[{""reference_id"": ""MetaCyc:PWY-5789"", ""source_assertion"": ""PWY-5789 explicitly contains PROPIONYL-COA-CARBOXY-RXN in its native reaction list and layout."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list; /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:PROPIONYL-COA-CARBOXY-RXN"", ""source_assertion"": ""The native reaction cross-references Rhea 23723. Its native pathway direction is retained through the selected current directed member."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]; /ptools-xml/Reaction/left; /ptools-xml/Reaction/right""}, {""reference_id"": ""RHEA:23721"", ""source_assertion"": ""The native cross-reference and selected directed reaction belong to the same original Rhea reaction family; current Rhea supplies explicit charged chemical forms and side coefficients."", ""source_locator"": ""http://rdf.rhea-db.org/23720/rh:directionalReaction -> http://rdf.rhea-db.org/23721; http://rdf.rhea-db.org/23720/rh:bidirectionalReaction -> http://rdf.rhea-db.org/23723""}]"	"[{""id"": ""MetaCyc:PROPIONYL-COA-CARBOXY-RXN"", ""source_sha256"": ""7fde942e7cd22e87b0f3ab23c2db314b37fa1c4252e0afabef930edba7db7ab6"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc PROPIONYL-COA-CARBOXY-RXN native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROPIONYL-COA-CARBOXY-RXN""}, {""id"": ""MetaCyc:PWY-5789"", ""source_sha256"": ""134f07865db2c2e86fcddf093a2e1cc1188f91a6a1f54a004d328efa52c5ab54"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc PWY-5789 full native pathway XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5789""}, {""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23721 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-087_622d60feacea	RHEA:20555	BFO:0000050	MetaCyc:PWY-5789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:METHYLMALONYL-COA-EPIM-RXN|MetaCyc:PWY-5789|RHEA:20555		"[{""reference_id"": ""MetaCyc:PWY-5789"", ""source_assertion"": ""PWY-5789 explicitly contains METHYLMALONYL-COA-EPIM-RXN in its native reaction list and layout."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list; /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:METHYLMALONYL-COA-EPIM-RXN"", ""source_assertion"": ""The native reaction cross-references Rhea 20556. Its native pathway direction is retained through the selected current directed member."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]; /ptools-xml/Reaction/left; /ptools-xml/Reaction/right""}, {""reference_id"": ""RHEA:20555"", ""source_assertion"": ""The native cross-reference and selected directed reaction belong to the same original Rhea reaction family; current Rhea supplies explicit charged chemical forms and side coefficients."", ""source_locator"": ""http://rdf.rhea-db.org/20553/rh:directionalReaction -> http://rdf.rhea-db.org/20555; http://rdf.rhea-db.org/20553/rh:bidirectionalReaction -> http://rdf.rhea-db.org/20556""}]"	"[{""id"": ""MetaCyc:METHYLMALONYL-COA-EPIM-RXN"", ""source_sha256"": ""494f1041d42ff4b61cad3b36a1abbc26021ccb8e9f845fe3f5abb4bb18cad63b"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc METHYLMALONYL-COA-EPIM-RXN native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:METHYLMALONYL-COA-EPIM-RXN""}, {""id"": ""MetaCyc:PWY-5789"", ""source_sha256"": ""134f07865db2c2e86fcddf093a2e1cc1188f91a6a1f54a004d328efa52c5ab54"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc PWY-5789 full native pathway XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5789""}, {""id"": ""RHEA:20555"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 20555 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-088_04774720650b	RHEA:22889	BFO:0000050	MetaCyc:PWY-5789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:METHYLMALONYL-COA-MUT-RXN|MetaCyc:PWY-5789|RHEA:22889	The selected methylmalonyl-CoA-to-succinyl-CoA direction follows the autotrophic cycle. The purified enzyme also catalyzes the reverse reaction at a higher measured rate.	"[{""reference_id"": ""MetaCyc:PWY-5789"", ""source_assertion"": ""PWY-5789 explicitly contains METHYLMALONYL-COA-MUT-RXN in its native reaction list and layout."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list; /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:METHYLMALONYL-COA-MUT-RXN"", ""source_assertion"": ""The native reaction cross-references Rhea 22891. Its native pathway direction is retained through the selected current directed member."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]; /ptools-xml/Reaction/left; /ptools-xml/Reaction/right""}, {""reference_id"": ""RHEA:22889"", ""source_assertion"": ""The native cross-reference and selected directed reaction belong to the same original Rhea reaction family; current Rhea supplies explicit charged chemical forms and side coefficients."", ""source_locator"": ""http://rdf.rhea-db.org/22888/rh:directionalReaction -> http://rdf.rhea-db.org/22889; http://rdf.rhea-db.org/22888/rh:bidirectionalReaction -> http://rdf.rhea-db.org/22891""}]"	"[{""id"": ""MetaCyc:METHYLMALONYL-COA-MUT-RXN"", ""source_sha256"": ""322c68783b32c46bc6c9ba48baec241cbfc708fb7f2ace8dbff6dc501a12216e"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc METHYLMALONYL-COA-MUT-RXN native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:METHYLMALONYL-COA-MUT-RXN""}, {""id"": ""MetaCyc:PWY-5789"", ""source_sha256"": ""134f07865db2c2e86fcddf093a2e1cc1188f91a6a1f54a004d328efa52c5ab54"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc PWY-5789 full native pathway XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5789""}, {""id"": ""RHEA:22889"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 22889 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-089_4f68035131f9	RHEA:26452	BFO:0000050	MetaCyc:PWY-5789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5789|MetaCyc:RXN-8891|RHEA:26452		"[{""reference_id"": ""MetaCyc:PWY-5789"", ""source_assertion"": ""PWY-5789 explicitly contains RXN-8891 in its native reaction list and layout."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list; /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:RXN-8891"", ""source_assertion"": ""The native reaction cross-references Rhea 26450. Its native pathway direction is retained through the selected current directed member."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]; /ptools-xml/Reaction/left; /ptools-xml/Reaction/right""}, {""reference_id"": ""RHEA:26452"", ""source_assertion"": ""The native cross-reference and selected directed reaction belong to the same original Rhea reaction family; current Rhea supplies explicit charged chemical forms and side coefficients."", ""source_locator"": ""http://rdf.rhea-db.org/26450/rh:id; http://rdf.rhea-db.org/26450/rh:directionalReaction -> http://rdf.rhea-db.org/26452""}]"	"[{""id"": ""MetaCyc:PWY-5789"", ""source_sha256"": ""134f07865db2c2e86fcddf093a2e1cc1188f91a6a1f54a004d328efa52c5ab54"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc PWY-5789 full native pathway XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5789""}, {""id"": ""MetaCyc:RXN-8891"", ""source_sha256"": ""0aab828521aa256b0ef14aded6417149b042c99f588be890ca0834b70f5e8576"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN-8891 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8891""}, {""id"": ""RHEA:26452"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26452 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-090_236a98e09a68	RHEA:26383	BFO:0000050	MetaCyc:PWY-5789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5789|MetaCyc:RXN-11002|RHEA:26383		"[{""reference_id"": ""MetaCyc:PWY-5789"", ""source_assertion"": ""PWY-5789 explicitly contains RXN-11002 in its native reaction list and layout."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list; /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:RXN-11002"", ""source_assertion"": ""The native reaction cross-references Rhea 26384. Its native pathway direction is retained through the selected current directed member."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]; /ptools-xml/Reaction/left; /ptools-xml/Reaction/right""}, {""reference_id"": ""RHEA:26383"", ""source_assertion"": ""The native cross-reference and selected directed reaction belong to the same original Rhea reaction family; current Rhea supplies explicit charged chemical forms and side coefficients."", ""source_locator"": ""http://rdf.rhea-db.org/26381/rh:directionalReaction -> http://rdf.rhea-db.org/26383; http://rdf.rhea-db.org/26381/rh:bidirectionalReaction -> http://rdf.rhea-db.org/26384""}]"	"[{""id"": ""MetaCyc:PWY-5789"", ""source_sha256"": ""134f07865db2c2e86fcddf093a2e1cc1188f91a6a1f54a004d328efa52c5ab54"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc PWY-5789 full native pathway XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5789""}, {""id"": ""MetaCyc:RXN-11002"", ""source_sha256"": ""199d100b61a6534555d045621397422f89132d14984a5b53a8aa7ef35ae69c38"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN-11002 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11002""}, {""id"": ""RHEA:26383"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26383 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-091_ec5f7702ce8c	RHEA:23129	BFO:0000050	MetaCyc:PWY-5789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5789|MetaCyc:RXN-9092|RHEA:23129		"[{""reference_id"": ""MetaCyc:PWY-5789"", ""source_assertion"": ""PWY-5789 explicitly contains RXN-9092 in its native reaction list and layout."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list; /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:RXN-9092"", ""source_assertion"": ""The native reaction cross-references Rhea 23129. Its native pathway direction is retained through the selected current directed member."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]; /ptools-xml/Reaction/left; /ptools-xml/Reaction/right""}, {""reference_id"": ""RHEA:23129"", ""source_assertion"": ""The native cross-reference and selected directed reaction belong to the same original Rhea reaction family; current Rhea supplies explicit charged chemical forms and side coefficients."", ""source_locator"": ""http://rdf.rhea-db.org/23128/rh:directionalReaction -> http://rdf.rhea-db.org/23129""}]"	"[{""id"": ""MetaCyc:PWY-5789"", ""source_sha256"": ""134f07865db2c2e86fcddf093a2e1cc1188f91a6a1f54a004d328efa52c5ab54"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc PWY-5789 full native pathway XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5789""}, {""id"": ""MetaCyc:RXN-9092"", ""source_sha256"": ""bedf7340e0d84084b0ce742eb76088b19d6187416d9a7e830c053340d870f6f5"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN-9092 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9092""}, {""id"": ""RHEA:23129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23129 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-092_230452bada95	RHEA:26531	BFO:0000050	MetaCyc:PWY-5789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5789|MetaCyc:RXN-8890|RHEA:26531	Native crotonyl-CoA leaves one conserved CoA hydroxyl stereocenter unspecified. The independently issued current Rhea/ChEBI structure is more specific; both sources agree on the trans acyl double bond. This is not an exact structural equivalence assertion.	"[{""reference_id"": ""MetaCyc:PWY-5789"", ""source_assertion"": ""PWY-5789 explicitly contains RXN-8890 in its native reaction list and layout."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list; /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:RXN-8890"", ""source_assertion"": ""The native reaction cross-references Rhea 26533. Its native pathway direction is retained through the selected current directed member."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]; /ptools-xml/Reaction/left; /ptools-xml/Reaction/right""}, {""reference_id"": ""RHEA:26531"", ""source_assertion"": ""The native cross-reference and selected directed reaction belong to the same original Rhea reaction family; current Rhea supplies explicit charged chemical forms and side coefficients."", ""source_locator"": ""http://rdf.rhea-db.org/26530/rh:bidirectionalReaction -> http://rdf.rhea-db.org/26533; http://rdf.rhea-db.org/26530/rh:directionalReaction -> http://rdf.rhea-db.org/26531""}]"	"[{""id"": ""MetaCyc:PWY-5789"", ""source_sha256"": ""134f07865db2c2e86fcddf093a2e1cc1188f91a6a1f54a004d328efa52c5ab54"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc PWY-5789 full native pathway XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5789""}, {""id"": ""MetaCyc:RXN-8890"", ""source_sha256"": ""66feb21adb4759bb654f467189deb9155621ade15d23fee30562353fd26ca025"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN-8890 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8890""}, {""id"": ""RHEA:26531"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26531 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-093_8f024c2f8429	RHEA:26560	BFO:0000050	MetaCyc:PWY-5789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5789|MetaCyc:RXN-11667|RHEA:26560	Native crotonyl-CoA leaves one conserved CoA hydroxyl stereocenter unspecified. The independently issued current Rhea/ChEBI structure is more specific; both sources agree on the trans acyl double bond. This is not an exact structural equivalence assertion.	"[{""reference_id"": ""MetaCyc:PWY-5789"", ""source_assertion"": ""PWY-5789 explicitly contains RXN-11667 in its native reaction list and layout."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list; /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:RXN-11667"", ""source_assertion"": ""The native reaction cross-references Rhea 26561. Its native pathway direction is retained through the selected current directed member."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]; /ptools-xml/Reaction/left; /ptools-xml/Reaction/right""}, {""reference_id"": ""RHEA:26560"", ""source_assertion"": ""The native cross-reference and selected directed reaction belong to the same original Rhea reaction family; current Rhea supplies explicit charged chemical forms and side coefficients."", ""source_locator"": ""http://rdf.rhea-db.org/26558/rh:directionalReaction -> http://rdf.rhea-db.org/26560; http://rdf.rhea-db.org/26558/rh:bidirectionalReaction -> http://rdf.rhea-db.org/26561""}]"	"[{""id"": ""MetaCyc:PWY-5789"", ""source_sha256"": ""134f07865db2c2e86fcddf093a2e1cc1188f91a6a1f54a004d328efa52c5ab54"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc PWY-5789 full native pathway XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5789""}, {""id"": ""MetaCyc:RXN-11667"", ""source_sha256"": ""2f1cb7bc8a3f195ce4a4517731ee208b346b2d331bee1aa0531a594ebc03c1b0"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN-11667 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11667""}, {""id"": ""RHEA:26560"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26560 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-094_9e6f6320b8e0	RHEA:30800	BFO:0000050	MetaCyc:PWY-5789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5789|MetaCyc:RXN-11662|RHEA:30800		"[{""reference_id"": ""MetaCyc:PWY-5789"", ""source_assertion"": ""PWY-5789 explicitly contains RXN-11662 in its native reaction list and layout."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list; /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:RXN-11662"", ""source_assertion"": ""The native reaction cross-references Rhea 30802. Its native pathway direction is retained through the selected current directed member."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]; /ptools-xml/Reaction/left; /ptools-xml/Reaction/right""}, {""reference_id"": ""RHEA:30800"", ""source_assertion"": ""The native cross-reference and selected directed reaction belong to the same original Rhea reaction family; current Rhea supplies explicit charged chemical forms and side coefficients."", ""source_locator"": ""http://rdf.rhea-db.org/30799/rh:bidirectionalReaction -> http://rdf.rhea-db.org/30802; http://rdf.rhea-db.org/30799/rh:directionalReaction -> http://rdf.rhea-db.org/30800""}]"	"[{""id"": ""MetaCyc:PWY-5789"", ""source_sha256"": ""134f07865db2c2e86fcddf093a2e1cc1188f91a6a1f54a004d328efa52c5ab54"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc PWY-5789 full native pathway XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5789""}, {""id"": ""MetaCyc:RXN-11662"", ""source_sha256"": ""337c165c720c090cad353a87047b29dc9cc65af787a4d79acd4ac74fb56a9562"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN-11662 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11662""}, {""id"": ""RHEA:30800"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 30800 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-095_139490d04a12	RHEA:21038	BFO:0000050	MetaCyc:PWY-5789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN|MetaCyc:PWY-5789|PMID:21169486|RHEA:21038		"[{""reference_id"": ""MetaCyc:PWY-5789"", ""source_assertion"": ""PWY-5789 explicitly contains ACETYL-COA-ACETYLTRANSFER-RXN in its native reaction list and layout."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list; /ptools-xml/Pathway/reaction-layout""}, {""reference_id"": ""MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN"", ""source_assertion"": ""The native reaction cross-references Rhea 21039. Its native pathway direction is retained through the selected current directed member."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]; /ptools-xml/Reaction/left; /ptools-xml/Reaction/right""}, {""reference_id"": ""RHEA:21038"", ""source_assertion"": ""The native cross-reference and selected directed reaction belong to the same original Rhea reaction family; current Rhea supplies explicit charged chemical forms and side coefficients."", ""source_locator"": ""http://rdf.rhea-db.org/21036/rh:directionalReaction -> http://rdf.rhea-db.org/21038; http://rdf.rhea-db.org/21036/rh:bidirectionalReaction -> http://rdf.rhea-db.org/21039""}, {""reference_id"": ""PMID:21169486"", ""source_assertion"": ""Isotopic labeling in autotrophic M. sedula TH2 supports the HP/HB cycle and identifies succinyl-CoA as a major biosynthetic exit."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[1]/p""}, {""reference_id"": ""PMID:21169486"", ""source_assertion"": ""The isotope experiments used autotrophic, microaerobic M. sedula TH2 (DSM 5348), grown at 75 degrees C and pH 2 with hydrogen, carbon dioxide and oxygen."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[2]/section[2]/p""}]"	"[{""id"": ""MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN"", ""source_sha256"": ""a66c6ecab35e4e7964861d27d4da987c92c6cfcdb5ee738c976a3a4df0404497"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ACETYL-COA-ACETYLTRANSFER-RXN native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ACETYL-COA-ACETYLTRANSFER-RXN""}, {""id"": ""MetaCyc:PWY-5789"", ""source_sha256"": ""134f07865db2c2e86fcddf093a2e1cc1188f91a6a1f54a004d328efa52c5ab54"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc PWY-5789 full native pathway XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5789""}, {""id"": ""PMID:21169486"", ""source_sha256"": ""2381c35a8ca1991eb874fa97df5c3358d8d512b690d32f4c6563b5eedc28b586"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Labeling and Enzyme Studies of the Central Carbon Metabolism in Metallosphaera sedula ▿"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3067578/""}, {""id"": ""RHEA:21038"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 21038 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-096_cd2276f4afaa	MetaCyc:CPLX-7580	BFO:0000051	MetaCyc:CPLX-7575	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7580|PMID:12581213	Four heterotrimeric units are a supported assembly model from native mass and subunit sequencing, not a high-resolution stoichiometric determination.	"[{""reference_id"": ""MetaCyc:CPLX-7580"", ""source_assertion"": ""The native holoenzyme contains four CPLX-7575 trimers."", ""source_locator"": ""/ptools-xml/Protein/component""}, {""reference_id"": ""PMID:12581213"", ""source_assertion"": ""Native mass and subunit sequencing support a proposed tetramer of heterotrimers."", ""source_locator"": ""Results, Purification and molecular properties of the enzyme, N-terminal sequences and subunit stoichiometry; Table 2""}]"	"[{""id"": ""MetaCyc:CPLX-7580"", ""source_sha256"": ""e4f2066c5879f91ee24326734e885cdecc8fe2e2167120c06a54090aca60c6c1"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc CPLX-7580 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7580""}, {""id"": ""PMID:12581213"", ""source_sha256"": ""1bf5ef7240acd43a7d99617eb7c06fcf6f72216af1d90781686c1959ea5a3baf"", ""source_version"": ""2003; retained tool-rendered public publisher full text; hash covers JSON tool representation, NOT original HTML"", ""title"": ""Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/full/10.1046/j.1432-1033.2003.03434.x""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-097_298740fe112d	MetaCyc:CPLX-7575	BFO:0000051	UniProtKB:A4YD22	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7575|NCBIProtein:AAO15572.1|PMID:12581213|UniProtKB:A4YD22	One copy per heterotrimer. Original gene sequences ground the assignment; the native biotin-carrier and biotin-carboxylase UniProt cross-references are reversed and are not followed.	"[{""reference_id"": ""MetaCyc:CPLX-7575"", ""source_assertion"": ""The native trimer contains one biotin-carboxylase, biotin-carrier and carboxyltransferase component."", ""source_locator"": ""/ptools-xml/Protein/component""}, {""reference_id"": ""NCBIProtein:AAO15572.1"", ""source_assertion"": ""The original carboxylase CDS translation exactly matches current UniProtKB:A4YD22; its original product assignment grounds the component role."", ""source_locator"": ""FT CDS /protein_id=\""AAO15572.1\""; /product; /translation""}, {""reference_id"": ""UniProtKB:A4YD22"", ""source_assertion"": ""The complete current sequence matches the original deposited carboxylase CDS and records the corresponding Msed locus."", ""source_locator"": ""/results/16/primaryAccession; /genes; /sequence/value; selected primaryAccession=A4YD22""}, {""reference_id"": ""PMID:12581213"", ""source_assertion"": ""Native mass and subunit sequencing support a proposed tetramer of heterotrimers."", ""source_locator"": ""Results, Purification and molecular properties of the enzyme, N-terminal sequences and subunit stoichiometry; Table 2""}]"	"[{""id"": ""MetaCyc:CPLX-7575"", ""source_sha256"": ""2fbdcc4dee6e8af5611483591ccc335daca80ecdda4d5c2abd2f4665980dd588"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc CPLX-7575 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7575""}, {""id"": ""NCBIProtein:AAO15572.1"", ""source_sha256"": ""c6bcfb14b63d7f569eb03c97c6992a81d6678d717e85dd1604b60fda5bf6b21e"", ""source_version"": ""Original ENA EMBL nucleotide record with CDS translation"", ""title"": ""Original archaeal carboxylase CDS AAO15572.1"", ""url"": ""https://www.ebi.ac.uk/ena/browser/api/embl/AF461116?download=false""}, {""id"": ""PMID:12581213"", ""source_sha256"": ""1bf5ef7240acd43a7d99617eb7c06fcf6f72216af1d90781686c1959ea5a3baf"", ""source_version"": ""2003; retained tool-rendered public publisher full text; hash covers JSON tool representation, NOT original HTML"", ""title"": ""Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/full/10.1046/j.1432-1033.2003.03434.x""}, {""id"": ""UniProtKB:A4YD22"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YD22 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-098_ffecb4610972	MetaCyc:CPLX-7575	BFO:0000051	UniProtKB:A4YD23	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7575|NCBIProtein:AAO15573.1|PMID:12581213|UniProtKB:A4YD23	One copy per heterotrimer. Original gene sequences ground the assignment; the native biotin-carrier and biotin-carboxylase UniProt cross-references are reversed and are not followed.	"[{""reference_id"": ""MetaCyc:CPLX-7575"", ""source_assertion"": ""The native trimer contains one biotin-carboxylase, biotin-carrier and carboxyltransferase component."", ""source_locator"": ""/ptools-xml/Protein/component""}, {""reference_id"": ""NCBIProtein:AAO15573.1"", ""source_assertion"": ""The original carboxylase CDS translation exactly matches current UniProtKB:A4YD23; its original product assignment grounds the component role."", ""source_locator"": ""FT CDS /protein_id=\""AAO15573.1\""; /product; /translation""}, {""reference_id"": ""UniProtKB:A4YD23"", ""source_assertion"": ""The complete current sequence matches the original deposited carboxylase CDS and records the corresponding Msed locus."", ""source_locator"": ""/results/18/primaryAccession; /genes; /sequence/value; selected primaryAccession=A4YD23""}, {""reference_id"": ""PMID:12581213"", ""source_assertion"": ""Native mass and subunit sequencing support a proposed tetramer of heterotrimers."", ""source_locator"": ""Results, Purification and molecular properties of the enzyme, N-terminal sequences and subunit stoichiometry; Table 2""}]"	"[{""id"": ""MetaCyc:CPLX-7575"", ""source_sha256"": ""2fbdcc4dee6e8af5611483591ccc335daca80ecdda4d5c2abd2f4665980dd588"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc CPLX-7575 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7575""}, {""id"": ""NCBIProtein:AAO15573.1"", ""source_sha256"": ""c6bcfb14b63d7f569eb03c97c6992a81d6678d717e85dd1604b60fda5bf6b21e"", ""source_version"": ""Original ENA EMBL nucleotide record with CDS translation"", ""title"": ""Original archaeal carboxylase CDS AAO15573.1"", ""url"": ""https://www.ebi.ac.uk/ena/browser/api/embl/AF461116?download=false""}, {""id"": ""PMID:12581213"", ""source_sha256"": ""1bf5ef7240acd43a7d99617eb7c06fcf6f72216af1d90781686c1959ea5a3baf"", ""source_version"": ""2003; retained tool-rendered public publisher full text; hash covers JSON tool representation, NOT original HTML"", ""title"": ""Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/full/10.1046/j.1432-1033.2003.03434.x""}, {""id"": ""UniProtKB:A4YD23"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YD23 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-099_fe7f31692a5d	MetaCyc:CPLX-7575	BFO:0000051	UniProtKB:A4YGI1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7575|NCBIProtein:AAO15571.1|PMID:12581213|UniProtKB:A4YGI1	One copy per heterotrimer. Original gene sequences ground the assignment; the native biotin-carrier and biotin-carboxylase UniProt cross-references are reversed and are not followed.	"[{""reference_id"": ""MetaCyc:CPLX-7575"", ""source_assertion"": ""The native trimer contains one biotin-carboxylase, biotin-carrier and carboxyltransferase component."", ""source_locator"": ""/ptools-xml/Protein/component""}, {""reference_id"": ""NCBIProtein:AAO15571.1"", ""source_assertion"": ""The original carboxylase CDS translation exactly matches current UniProtKB:A4YGI1; its original product assignment grounds the component role."", ""source_locator"": ""FT CDS /protein_id=\""AAO15571.1\""; /product; /translation""}, {""reference_id"": ""UniProtKB:A4YGI1"", ""source_assertion"": ""The complete current sequence matches the original deposited carboxylase CDS and records the corresponding Msed locus."", ""source_locator"": ""/results/22/primaryAccession; /genes; /sequence/value; selected primaryAccession=A4YGI1""}, {""reference_id"": ""PMID:12581213"", ""source_assertion"": ""Native mass and subunit sequencing support a proposed tetramer of heterotrimers."", ""source_locator"": ""Results, Purification and molecular properties of the enzyme, N-terminal sequences and subunit stoichiometry; Table 2""}]"	"[{""id"": ""MetaCyc:CPLX-7575"", ""source_sha256"": ""2fbdcc4dee6e8af5611483591ccc335daca80ecdda4d5c2abd2f4665980dd588"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc CPLX-7575 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7575""}, {""id"": ""NCBIProtein:AAO15571.1"", ""source_sha256"": ""ad39cca1e4b0f521bfcee44566406ae2355a32914fb7bc4a34023ec2eaa26d01"", ""source_version"": ""Original ENA EMBL nucleotide record with CDS translation"", ""title"": ""Original archaeal carboxylase CDS AAO15571.1"", ""url"": ""https://www.ebi.ac.uk/ena/browser/api/embl/AF461115?download=false""}, {""id"": ""PMID:12581213"", ""source_sha256"": ""1bf5ef7240acd43a7d99617eb7c06fcf6f72216af1d90781686c1959ea5a3baf"", ""source_version"": ""2003; retained tool-rendered public publisher full text; hash covers JSON tool representation, NOT original HTML"", ""title"": ""Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/full/10.1046/j.1432-1033.2003.03434.x""}, {""id"": ""UniProtKB:A4YGI1"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YGI1 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-100_0d00871db5b9	MetaCyc:CPLX-7577	BFO:0000051	UniProtKB:A4YEN2	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7577|MetaCyc:MONOMER-13726|PMID:17041055|UniProtKB:A4YEN2	Four subunits follow the curated native complex and approximate native mass. The S. tokodaii recombinant preparation bound RNA, making its own oligomeric estimate ambiguous.	"[{""reference_id"": ""MetaCyc:CPLX-7577"", ""source_assertion"": ""The native complex contains 4 copy/copies of MONOMER-13726."", ""source_locator"": ""/ptools-xml/Protein/component""}, {""reference_id"": ""MetaCyc:MONOMER-13726"", ""source_assertion"": ""The native protein cross-references UniProtKB:A4YEN2."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:A4YEN2"", ""source_assertion"": ""The current entry identifies this sequence and its Msed locus in Metallosphaera sedula DSM 5348 / ATCC 51363."", ""source_locator"": ""/results/2/primaryAccession; /genes; /organism; /sequence/value; selected primaryAccession=A4YEN2""}, {""reference_id"": ""PMID:17041055"", ""source_assertion"": ""Partially purified native M. sedula malonyl-CoA reductase had an apparent 150-kDa mass and 43-kDa band, suggesting a homotetramer."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[3]/section[2]/p""}]"	"[{""id"": ""MetaCyc:CPLX-7577"", ""source_sha256"": ""08131729d7015aa932508bdc51ab72b718c7c8a9a9025f93e69a70e5cfabf232"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc CPLX-7577 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7577""}, {""id"": ""MetaCyc:MONOMER-13726"", ""source_sha256"": ""25adcf66aa701111a82c6c9426cb6d1c9cdd01089bc7e3884332f63230aad587"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc MONOMER-13726 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-13726""}, {""id"": ""PMID:17041055"", ""source_sha256"": ""f5a96553acec0168b5c3fef08f422577acedda1f0088efc1e8d54c95400bd1a9"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Malonyl-Coenzyme A Reductase in the Modified 3-Hydroxypropionate Cycle for Autotrophic Carbon Fixation in Archaeal Metallosphaera and Sulfolobus spp. ▿"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1698253/""}, {""id"": ""UniProtKB:A4YEN2"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YEN2 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-101_482868726356	MetaCyc:CPLX-7947	BFO:0000051	UniProtKB:A4YI81	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7947|MetaCyc:MONOMER-13727|PMID:19684143|UniProtKB:A4YI81		"[{""reference_id"": ""MetaCyc:CPLX-7947"", ""source_assertion"": ""The native complex contains 3 copy/copies of MONOMER-13727."", ""source_locator"": ""/ptools-xml/Protein/component""}, {""reference_id"": ""MetaCyc:MONOMER-13727"", ""source_assertion"": ""The native protein cross-references UniProtKB:A4YI81."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:A4YI81"", ""source_assertion"": ""The current entry identifies this sequence and its Msed locus in Metallosphaera sedula DSM 5348 / ATCC 51363."", ""source_locator"": ""/results/10/primaryAccession; /genes; /organism; /sequence/value; selected primaryAccession=A4YI81""}, {""reference_id"": ""PMID:19684143"", ""source_assertion"": ""Recombinant Msed_1993 reductase had a 105 +/- 10-kDa apparent native mass, supporting a trimer."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[3]/section[3]/p""}]"	"[{""id"": ""MetaCyc:CPLX-7947"", ""source_sha256"": ""9f2b4be6ef6c88e0b9be6f50d43c30da443a6661330444dcd604675447246a05"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc CPLX-7947 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7947""}, {""id"": ""MetaCyc:MONOMER-13727"", ""source_sha256"": ""901a30cfa49a71dc27bf640a2ba402987a632c468003012102038c4c4f3c01d8"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc MONOMER-13727 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-13727""}, {""id"": ""PMID:19684143"", ""source_sha256"": ""007d86b186a3da978f6ca10256d101d930828314380fa1071fafbeefa0ee6807"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Malonic Semialdehyde Reductase, Succinic Semialdehyde Reductase, and Succinyl-Coenzyme A Reductase from Metallosphaera sedula : Enzymes of the Autotrophic 3-Hydroxypropionate/4-Hydroxybutyrate Cycle in Sulfolobales ▿"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2753041/""}, {""id"": ""UniProtKB:A4YI81"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YI81 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-102_11b7489ce2de	MetaCyc:CPLX-7579	BFO:0000051	UniProtKB:A4YGR1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7579|MetaCyc:MONOMER-13728|PMID:18165310|UniProtKB:A4YGR1		"[{""reference_id"": ""MetaCyc:CPLX-7579"", ""source_assertion"": ""The native complex contains 4 copy/copies of MONOMER-13728."", ""source_locator"": ""/ptools-xml/Protein/component""}, {""reference_id"": ""MetaCyc:MONOMER-13728"", ""source_assertion"": ""The native protein cross-references UniProtKB:A4YGR1."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:A4YGR1"", ""source_assertion"": ""The current entry identifies this sequence and its Msed locus in Metallosphaera sedula DSM 5348 / ATCC 51363."", ""source_locator"": ""/results/1/primaryAccession; /genes; /organism; /sequence/value; selected primaryAccession=A4YGR1""}, {""reference_id"": ""PMID:18165310"", ""source_assertion"": ""Native M. sedula 3-hydroxypropionyl-CoA synthetase showed a 340-kDa apparent mass and 78-kDa subunit band, supporting a homotetramer."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[3]/section[4]/p""}]"	"[{""id"": ""MetaCyc:CPLX-7579"", ""source_sha256"": ""df0abd5c467a2c424c367b40676b7e95964a4e2c73146dc70b39050039847a1d"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc CPLX-7579 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7579""}, {""id"": ""MetaCyc:MONOMER-13728"", ""source_sha256"": ""6ed326545f204dcd8cc2a6d9260e0a4e3b7e97189030c9f783d2312565e2e2b6"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc MONOMER-13728 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-13728""}, {""id"": ""PMID:18165310"", ""source_sha256"": ""95715028d10f99be1889811d15d7816648989e47d4f573baf64804141f8d96ed"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""3-Hydroxypropionyl-Coenzyme A Synthetase from Metallosphaera sedula , an Enzyme Involved in Autotrophic CO 2 Fixation ▿"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2238213/""}, {""id"": ""UniProtKB:A4YGR1"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YGR1 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-103_a6398c280131	MetaCyc:CPLX-8530	BFO:0000051	UniProtKB:A4YEG2	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8530|MetaCyc:MONOMER-13731|PMID:22752162|UniProtKB:A4YEG2		"[{""reference_id"": ""MetaCyc:CPLX-8530"", ""source_assertion"": ""The native complex contains 2 copy/copies of MONOMER-13731."", ""source_locator"": ""/ptools-xml/Protein/component""}, {""reference_id"": ""MetaCyc:MONOMER-13731"", ""source_assertion"": ""The native protein cross-references UniProtKB:A4YEG2."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:A4YEG2"", ""source_assertion"": ""The current entry identifies this sequence and its Msed locus in Metallosphaera sedula DSM 5348 / ATCC 51363."", ""source_locator"": ""/results/11/primaryAccession; /genes; /organism; /sequence/value; selected primaryAccession=A4YEG2""}, {""reference_id"": ""PMID:22752162"", ""source_assertion"": ""Recombinant Msed_0639 methylmalonyl-CoA epimerase is a homodimer."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[1]/p""}]"	"[{""id"": ""MetaCyc:CPLX-8530"", ""source_sha256"": ""4ecbc6c7101319408bee98d44c42a9e03091d20f44e56c95234a2a7dd9811bb0"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc CPLX-8530 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8530""}, {""id"": ""MetaCyc:MONOMER-13731"", ""source_sha256"": ""f9a7f9e06743a67f9914219a11ba0d495f5f0bcd61bdde19f17be2449835b08b"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc MONOMER-13731 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-13731""}, {""id"": ""PMID:22752162"", ""source_sha256"": ""3a27b76d333daa5dc398163e3346114c52c1a895c02a62a637716000dfd8871b"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Epimerase (Msed_0639) and Mutase (Msed_0638 and Msed_2055) Convert ( S )-Methylmalonyl-Coenzyme A (CoA) to Succinyl-CoA in the Metallosphaera sedula 3-Hydroxypropionate/4-Hydroxybutyrate Cycle"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3416614/""}, {""id"": ""UniProtKB:A4YEG2"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YEG2 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-104_a2edcc54b6a9	MetaCyc:CPLX-7576	BFO:0000051	UniProtKB:A4YEG1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7576|MetaCyc:MONOMER-13732|PMID:22752162|UniProtKB:A4YEG1	Two copies of this subunit in the primary-supported heterotetramer. The ambiguous nested native dimer hierarchy is not multiplied into an alpha4beta4 assembly.	"[{""reference_id"": ""MetaCyc:CPLX-7576"", ""source_assertion"": ""The native mutase has alpha- and beta-subunit complex components. Nested component coefficients do not independently establish total monomer stoichiometry."", ""source_locator"": ""/ptools-xml/Protein/component""}, {""reference_id"": ""MetaCyc:MONOMER-13732"", ""source_assertion"": ""The native mutase subunit cross-references UniProtKB:A4YEG1."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:A4YEG1"", ""source_assertion"": ""The current entry identifies the M. sedula mutase subunit and its locus."", ""source_locator"": ""/results/15/genes; /primaryAccession; /sequence/value; selected primaryAccession=A4YEG1""}, {""reference_id"": ""PMID:22752162"", ""source_assertion"": ""Coexpressed Msed_0638 and Msed_2055 formed a 173.7-kDa active alpha2beta2 mutase; two copies of each subunit are supported."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[4]/section[2]/p[2]""}]"	"[{""id"": ""MetaCyc:CPLX-7576"", ""source_sha256"": ""1176542282597dfd7e3f798f188d907a1ba86963ee4ac389d69b7ade4fd11e52"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc CPLX-7576 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7576""}, {""id"": ""MetaCyc:MONOMER-13732"", ""source_sha256"": ""9f9ccc5610cb6975af398741ffeaec8997b2c6a01a4a59bf6e4587ebbcfc302e"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc MONOMER-13732 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-13732""}, {""id"": ""PMID:22752162"", ""source_sha256"": ""3a27b76d333daa5dc398163e3346114c52c1a895c02a62a637716000dfd8871b"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Epimerase (Msed_0639) and Mutase (Msed_0638 and Msed_2055) Convert ( S )-Methylmalonyl-Coenzyme A (CoA) to Succinyl-CoA in the Metallosphaera sedula 3-Hydroxypropionate/4-Hydroxybutyrate Cycle"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3416614/""}, {""id"": ""UniProtKB:A4YEG1"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YEG1 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-105_c9358777073e	MetaCyc:CPLX-7576	BFO:0000051	UniProtKB:A4YIE3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7576|MetaCyc:MONOMER-13733|PMID:22752162|UniProtKB:A4YIE3	Two copies of this subunit in the primary-supported heterotetramer. The ambiguous nested native dimer hierarchy is not multiplied into an alpha4beta4 assembly.	"[{""reference_id"": ""MetaCyc:CPLX-7576"", ""source_assertion"": ""The native mutase has alpha- and beta-subunit complex components. Nested component coefficients do not independently establish total monomer stoichiometry."", ""source_locator"": ""/ptools-xml/Protein/component""}, {""reference_id"": ""MetaCyc:MONOMER-13733"", ""source_assertion"": ""The native mutase subunit cross-references UniProtKB:A4YIE3."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:A4YIE3"", ""source_assertion"": ""The current entry identifies the M. sedula mutase subunit and its locus."", ""source_locator"": ""/results/8/genes; /primaryAccession; /sequence/value; selected primaryAccession=A4YIE3""}, {""reference_id"": ""PMID:22752162"", ""source_assertion"": ""Coexpressed Msed_0638 and Msed_2055 formed a 173.7-kDa active alpha2beta2 mutase; two copies of each subunit are supported."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[4]/section[2]/p[2]""}]"	"[{""id"": ""MetaCyc:CPLX-7576"", ""source_sha256"": ""1176542282597dfd7e3f798f188d907a1ba86963ee4ac389d69b7ade4fd11e52"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc CPLX-7576 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7576""}, {""id"": ""MetaCyc:MONOMER-13733"", ""source_sha256"": ""d349a993e12b083e4da4040c0caee59ae21cc826305534ed5cef48dd0fe75ed0"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc MONOMER-13733 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-13733""}, {""id"": ""PMID:22752162"", ""source_sha256"": ""3a27b76d333daa5dc398163e3346114c52c1a895c02a62a637716000dfd8871b"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Epimerase (Msed_0639) and Mutase (Msed_0638 and Msed_2055) Convert ( S )-Methylmalonyl-Coenzyme A (CoA) to Succinyl-CoA in the Metallosphaera sedula 3-Hydroxypropionate/4-Hydroxybutyrate Cycle"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3416614/""}, {""id"": ""UniProtKB:A4YIE3"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YIE3 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-106_7ef75fac2d96	MetaCyc:CPLX-7948	BFO:0000051	UniProtKB:A4YGN0	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7948|MetaCyc:MONOMER-13734|PMID:19684143|PMID:27771364|UniProtKB:A4YGN0	Two copies describe the native-database and 2009 dimer model. A later recombinant preparation was interpreted as pentameric; the discrepancy is unresolved, not evidence for a universal dimer. Direct reductase experiments override the unrelated current UniProt catalytic annotation.	"[{""reference_id"": ""MetaCyc:CPLX-7948"", ""source_assertion"": ""The native complex contains 2 copy/copies of MONOMER-13734."", ""source_locator"": ""/ptools-xml/Protein/component""}, {""reference_id"": ""MetaCyc:MONOMER-13734"", ""source_assertion"": ""The native protein cross-references UniProtKB:A4YGN0."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:A4YGN0"", ""source_assertion"": ""The current entry identifies this sequence and its Msed locus in Metallosphaera sedula DSM 5348 / ATCC 51363."", ""source_locator"": ""/results/5/primaryAccession; /genes; /organism; /sequence/value; selected primaryAccession=A4YGN0""}, {""reference_id"": ""PMID:19684143"", ""source_assertion"": ""Msed_1424 succinic semialdehyde reductase had a 74 +/- 7-kDa native mass, suggesting a homodimer."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[3]/section[6]/p""}, {""reference_id"": ""PMID:27771364"", ""source_assertion"": ""A later recombinant Msed_1424 preparation had an apparent mass near 200 kDa and was interpreted as a homopentamer, differing from the earlier dimer estimate."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[4]/section[1]/section[3]/p""}]"	"[{""id"": ""MetaCyc:CPLX-7948"", ""source_sha256"": ""1fbef7cadbaa530f24560a21ed0b8437539af10dc41f682268b764598db489be"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc CPLX-7948 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7948""}, {""id"": ""MetaCyc:MONOMER-13734"", ""source_sha256"": ""1776b3bd0d05f3ebb3f33f170bed4fd3bd1a3f1fdce5991af0615bdf2807c165"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc MONOMER-13734 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-13734""}, {""id"": ""PMID:19684143"", ""source_sha256"": ""007d86b186a3da978f6ca10256d101d930828314380fa1071fafbeefa0ee6807"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Malonic Semialdehyde Reductase, Succinic Semialdehyde Reductase, and Succinyl-Coenzyme A Reductase from Metallosphaera sedula : Enzymes of the Autotrophic 3-Hydroxypropionate/4-Hydroxybutyrate Cycle in Sulfolobales ▿"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2753041/""}, {""id"": ""PMID:27771364"", ""source_sha256"": ""426c21ac77b49b5d82ca871d3d0eb4cd523b22454b4084fea626fc592febeedd"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Reaction Kinetic Analysis of the 3-Hydroxypropionate/4-Hydroxybutyrate CO 2 Fixation Cycle in Extremely Thermoacidophilic Archaea"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC5433351/?pdf=render""}, {""id"": ""UniProtKB:A4YGN0"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YGN0 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-107_f26d8a54a900	MetaCyc:CPLX-7580	pathwaymech:catalyzes	RHEA:11309	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14657|PMID:12581213	The same experimentally purified holoenzyme catalyzes both acetyl-CoA and propionyl-CoA carboxylation.	"[{""reference_id"": ""MetaCyc:ENZRXN-14657"", ""source_assertion"": ""The native enzyme-reaction object links CPLX-7580 to its pathway reaction."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/enzyme; /ptools-xml/Enzymatic-Reaction/reaction""}, {""reference_id"": ""PMID:12581213"", ""source_assertion"": ""Purified TH2 carboxylase fixes bicarbonate into acetyl-CoA with ATP."", ""source_locator"": ""Results, Catalytic properties; Table 2""}]"	"[{""id"": ""MetaCyc:ENZRXN-14657"", ""source_sha256"": ""3a6e87da8420073fc09d5bea370c703031b560306b3be4c37e74c34bdb98e0f2"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14657 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14657""}, {""id"": ""PMID:12581213"", ""source_sha256"": ""1bf5ef7240acd43a7d99617eb7c06fcf6f72216af1d90781686c1959ea5a3baf"", ""source_version"": ""2003; retained tool-rendered public publisher full text; hash covers JSON tool representation, NOT original HTML"", ""title"": ""Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/full/10.1046/j.1432-1033.2003.03434.x""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-108_e76c73cbc330	MetaCyc:CPLX-7580	pathwaymech:catalyzes	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14658|PMID:12581213		"[{""reference_id"": ""MetaCyc:ENZRXN-14658"", ""source_assertion"": ""The native enzyme-reaction object links CPLX-7580 to its pathway reaction."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/enzyme; /ptools-xml/Enzymatic-Reaction/reaction""}, {""reference_id"": ""PMID:12581213"", ""source_assertion"": ""The same purified holoenzyme carboxylates propionyl-CoA."", ""source_locator"": ""Results, Catalytic properties; Table 2""}]"	"[{""id"": ""MetaCyc:ENZRXN-14658"", ""source_sha256"": ""1ccdee3edc3edcc187bd7e1c6054ce869289063b2293fbe248505cf5a21dfade"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14658 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14658""}, {""id"": ""PMID:12581213"", ""source_sha256"": ""1bf5ef7240acd43a7d99617eb7c06fcf6f72216af1d90781686c1959ea5a3baf"", ""source_version"": ""2003; retained tool-rendered public publisher full text; hash covers JSON tool representation, NOT original HTML"", ""title"": ""Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/full/10.1046/j.1432-1033.2003.03434.x""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-109_822ffcdfc762	MetaCyc:CPLX-7577	pathwaymech:catalyzes	RHEA:26448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14667|PMID:19684143	The bifunctional native reductase assignment is retained; cross-species recombinant experiments are not presented as measurements of the selected M. sedula construct.	"[{""reference_id"": ""MetaCyc:ENZRXN-14667"", ""source_assertion"": ""The native enzyme-reaction object links CPLX-7577 to its pathway reaction."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/enzyme; /ptools-xml/Enzymatic-Reaction/reaction""}, {""reference_id"": ""PMID:19684143"", ""source_assertion"": ""Native M. sedula malonyl-CoA and succinyl-CoA reductase activities copurified at the same measured rate; peptide analysis assigned the protein to Msed_0709."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[3]/section[8]/p""}]"	"[{""id"": ""MetaCyc:ENZRXN-14667"", ""source_sha256"": ""4e9ce864171067ac806ffdff111fb444cbdf04a294bf7dd39caf5a821ee8bf8d"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14667 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14667""}, {""id"": ""PMID:19684143"", ""source_sha256"": ""007d86b186a3da978f6ca10256d101d930828314380fa1071fafbeefa0ee6807"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Malonic Semialdehyde Reductase, Succinic Semialdehyde Reductase, and Succinyl-Coenzyme A Reductase from Metallosphaera sedula : Enzymes of the Autotrophic 3-Hydroxypropionate/4-Hydroxybutyrate Cycle in Sulfolobales ▿"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2753041/""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-110_b7972bf6b684	MetaCyc:CPLX-7577	pathwaymech:catalyzes	RHEA:26452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14674|PMID:19684143	The bifunctional native reductase assignment is retained; cross-species recombinant experiments are not presented as measurements of the selected M. sedula construct.	"[{""reference_id"": ""MetaCyc:ENZRXN-14674"", ""source_assertion"": ""The native enzyme-reaction object links CPLX-7577 to its pathway reaction."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/enzyme; /ptools-xml/Enzymatic-Reaction/reaction""}, {""reference_id"": ""PMID:19684143"", ""source_assertion"": ""Native M. sedula malonyl-CoA and succinyl-CoA reductase activities copurified at the same measured rate; peptide analysis assigned the protein to Msed_0709."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[3]/section[8]/p""}]"	"[{""id"": ""MetaCyc:ENZRXN-14674"", ""source_sha256"": ""bc102ce2ab7d597dcbca4baa1d36672c48c9c4eed713af2c172899ec673b80ab"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14674 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14674""}, {""id"": ""PMID:19684143"", ""source_sha256"": ""007d86b186a3da978f6ca10256d101d930828314380fa1071fafbeefa0ee6807"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Malonic Semialdehyde Reductase, Succinic Semialdehyde Reductase, and Succinyl-Coenzyme A Reductase from Metallosphaera sedula : Enzymes of the Autotrophic 3-Hydroxypropionate/4-Hydroxybutyrate Cycle in Sulfolobales ▿"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2753041/""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-111_dcb536dac503	MetaCyc:CPLX-7947	pathwaymech:catalyzes	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14668|PMID:19684143		"[{""reference_id"": ""MetaCyc:ENZRXN-14668"", ""source_assertion"": ""The native enzyme-reaction object links CPLX-7947 to its pathway reaction."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/enzyme; /ptools-xml/Enzymatic-Reaction/reaction""}, {""reference_id"": ""PMID:19684143"", ""source_assertion"": ""Purified recombinant Msed_1993 catalyzes NADPH-dependent malonic semialdehyde reduction, with a reported activity of 200 micromol/min/mg."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[3]/section[3]/p""}]"	"[{""id"": ""MetaCyc:ENZRXN-14668"", ""source_sha256"": ""92eb911dfa4e67531c028f8e62e0c36b332af7062027104c7e3e95a04ee02922"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14668 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14668""}, {""id"": ""PMID:19684143"", ""source_sha256"": ""007d86b186a3da978f6ca10256d101d930828314380fa1071fafbeefa0ee6807"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Malonic Semialdehyde Reductase, Succinic Semialdehyde Reductase, and Succinyl-Coenzyme A Reductase from Metallosphaera sedula : Enzymes of the Autotrophic 3-Hydroxypropionate/4-Hydroxybutyrate Cycle in Sulfolobales ▿"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2753041/""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-112_c35d512504eb	MetaCyc:CPLX-7579	pathwaymech:catalyzes	RHEA:26535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14669|PMID:18165310|PMID:27771364	The native tetramer and its activity are supported separately. Later recombinant HPCS associated with HPCD; this association is retained as experimental context without assigning the larger assembly to the native homotetramer identifier.	"[{""reference_id"": ""MetaCyc:ENZRXN-14669"", ""source_assertion"": ""The native enzyme-reaction object links CPLX-7579 to its pathway reaction."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/enzyme; /ptools-xml/Enzymatic-Reaction/reaction""}, {""reference_id"": ""PMID:18165310"", ""source_assertion"": ""Native M. sedula 3-hydroxypropionyl-CoA synthetase was purified 95-fold to apparent homogeneity from autotrophically grown cells."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[3]/section[3]/p""}, {""reference_id"": ""PMID:27771364"", ""source_assertion"": ""Soluble recombinant Msed_1456 required coexpression with Msed_2001; the purified preparation suggested an (HPCS)4(HPCD)8 association."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[4]/section[1]/section[2]/p""}]"	"[{""id"": ""MetaCyc:ENZRXN-14669"", ""source_sha256"": ""67cd18cbaab82a6fe20e7c34a5a2ce4c109e0d5ae53ef370a7145f46bc85cb96"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14669 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14669""}, {""id"": ""PMID:18165310"", ""source_sha256"": ""95715028d10f99be1889811d15d7816648989e47d4f573baf64804141f8d96ed"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""3-Hydroxypropionyl-Coenzyme A Synthetase from Metallosphaera sedula , an Enzyme Involved in Autotrophic CO 2 Fixation ▿"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2238213/""}, {""id"": ""PMID:27771364"", ""source_sha256"": ""426c21ac77b49b5d82ca871d3d0eb4cd523b22454b4084fea626fc592febeedd"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Reaction Kinetic Analysis of the 3-Hydroxypropionate/4-Hydroxybutyrate CO 2 Fixation Cycle in Extremely Thermoacidophilic Archaea"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC5433351/?pdf=render""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-113_37210e5e189d	MetaCyc:CPLX-8530	pathwaymech:catalyzes	RHEA:20555	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14672|PMID:22752162		"[{""reference_id"": ""MetaCyc:ENZRXN-14672"", ""source_assertion"": ""The native enzyme-reaction object links CPLX-8530 to its pathway reaction."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/enzyme; /ptools-xml/Enzymatic-Reaction/reaction""}, {""reference_id"": ""PMID:22752162"", ""source_assertion"": ""Recombinant Msed_0639 and Msed_0638/Msed_2055 together convert (S)-methylmalonyl-CoA to succinyl-CoA."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[1]/p""}]"	"[{""id"": ""MetaCyc:ENZRXN-14672"", ""source_sha256"": ""33ccf23f4519da04c629885003fbf33e28466555f0dcee8c4cf2eb900f8edc85"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14672 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14672""}, {""id"": ""PMID:22752162"", ""source_sha256"": ""3a27b76d333daa5dc398163e3346114c52c1a895c02a62a637716000dfd8871b"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Epimerase (Msed_0639) and Mutase (Msed_0638 and Msed_2055) Convert ( S )-Methylmalonyl-Coenzyme A (CoA) to Succinyl-CoA in the Metallosphaera sedula 3-Hydroxypropionate/4-Hydroxybutyrate Cycle"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3416614/""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-114_19eb5f9fd3eb	MetaCyc:CPLX-7576	pathwaymech:catalyzes	RHEA:22889	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14673|PMID:22752162		"[{""reference_id"": ""MetaCyc:ENZRXN-14673"", ""source_assertion"": ""The native enzyme-reaction object links CPLX-7576 to its pathway reaction."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/enzyme; /ptools-xml/Enzymatic-Reaction/reaction""}, {""reference_id"": ""PMID:22752162"", ""source_assertion"": ""The reconstituted alpha2beta2 mutase acts on methylmalonyl-CoA and also on succinyl-CoA; the cycle consumes the former."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[4]/section[3]/p[3]""}]"	"[{""id"": ""MetaCyc:ENZRXN-14673"", ""source_sha256"": ""d09f52a59682d3f216ea7f43772b2cee8c6850f5e482c3de370b7c8190639613"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14673 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14673""}, {""id"": ""PMID:22752162"", ""source_sha256"": ""3a27b76d333daa5dc398163e3346114c52c1a895c02a62a637716000dfd8871b"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Epimerase (Msed_0639) and Mutase (Msed_0638 and Msed_2055) Convert ( S )-Methylmalonyl-Coenzyme A (CoA) to Succinyl-CoA in the Metallosphaera sedula 3-Hydroxypropionate/4-Hydroxybutyrate Cycle"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3416614/""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-115_4cae00a2059e	MetaCyc:CPLX-7948	pathwaymech:catalyzes	RHEA:26383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14675|PMID:19684143|PMID:27771364	The experimentally characterized NADPH reductase is used despite the conflicting current UniProt acetylating-dehydrogenase assignment.	"[{""reference_id"": ""MetaCyc:ENZRXN-14675"", ""source_assertion"": ""The native enzyme-reaction object links CPLX-7948 to its pathway reaction."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/enzyme; /ptools-xml/Enzymatic-Reaction/reaction""}, {""reference_id"": ""PMID:19684143"", ""source_assertion"": ""Purified recombinant Msed_1424 reduces succinic semialdehyde with NADPH, with a reported activity of 700 micromol/min/mg at 65 degrees C."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[3]/section[6]/p""}, {""reference_id"": ""PMID:27771364"", ""source_assertion"": ""Recombinant Msed_1424 reduced succinic semialdehyde with a reported Vmax of 682 micromol/min/mg; the preparation was interpreted as pentameric."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[4]/section[1]/section[3]/p""}]"	"[{""id"": ""MetaCyc:ENZRXN-14675"", ""source_sha256"": ""3288d7008ef8c49e977ed0f695988abc86f08298e07ea781c6b1fce5d48bfe03"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14675 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14675""}, {""id"": ""PMID:19684143"", ""source_sha256"": ""007d86b186a3da978f6ca10256d101d930828314380fa1071fafbeefa0ee6807"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Malonic Semialdehyde Reductase, Succinic Semialdehyde Reductase, and Succinyl-Coenzyme A Reductase from Metallosphaera sedula : Enzymes of the Autotrophic 3-Hydroxypropionate/4-Hydroxybutyrate Cycle in Sulfolobales ▿"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2753041/""}, {""id"": ""PMID:27771364"", ""source_sha256"": ""426c21ac77b49b5d82ca871d3d0eb4cd523b22454b4084fea626fc592febeedd"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Reaction Kinetic Analysis of the 3-Hydroxypropionate/4-Hydroxybutyrate CO 2 Fixation Cycle in Extremely Thermoacidophilic Archaea"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC5433351/?pdf=render""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-116_7a46a5e4cec5	UniProtKB:A4YI89	pathwaymech:enables	RHEA:26519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14670|PMID:19429610|PMID:27771364|UniProtKB:A4YI89	Functional activity is supported directly. The earlier recombinant preparation was interpreted as monomeric, whereas the later preparation was interpreted as octameric. The source difference is unresolved and monomer sufficiency is not asserted.	"[{""reference_id"": ""MetaCyc:ENZRXN-14670"", ""source_assertion"": ""The native enzyme-reaction object assigns this functional step to its linked protein."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/enzyme; /ptools-xml/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:A4YI89"", ""source_assertion"": ""The current sequence entry identifies A4YI89 and its M. sedula DSM 5348 locus; sequence identity is distinct from the strength of catalytic annotation."", ""source_locator"": ""/results/3/primaryAccession; /genes; /organism; /sequence/value; selected primaryAccession=A4YI89""}, {""reference_id"": ""PMID:19429610"", ""source_assertion"": ""Purified recombinant Msed_2001 catalyzes 3-hydroxypropionyl-CoA dehydration; its apparent molecular mass indicated a monomer."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[3]/section[7]/p[1]""}, {""reference_id"": ""PMID:27771364"", ""source_assertion"": ""The recombinant Msed_2001 preparation had an apparent 220-kDa mass, interpreted as a homooctamer, and measured dehydratase activity."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[4]/section[1]/section[1]/p""}]"	"[{""id"": ""MetaCyc:ENZRXN-14670"", ""source_sha256"": ""9c05c1b621bf3aebf8917ab82469acab0f1afd6521b06481e97ef4db371f72ad"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14670 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14670""}, {""id"": ""PMID:19429610"", ""source_sha256"": ""f76c2395f75cbad5a381e360a7a179882bc65b405249ae438b2f55e676e85628"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""3-Hydroxypropionyl-Coenzyme A Dehydratase and Acryloyl-Coenzyme A Reductase, Enzymes of the Autotrophic 3-Hydroxypropionate/4-Hydroxybutyrate Cycle in the Sulfolobales ▿"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2704735/""}, {""id"": ""PMID:27771364"", ""source_sha256"": ""426c21ac77b49b5d82ca871d3d0eb4cd523b22454b4084fea626fc592febeedd"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Reaction Kinetic Analysis of the 3-Hydroxypropionate/4-Hydroxybutyrate CO 2 Fixation Cycle in Extremely Thermoacidophilic Archaea"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC5433351/?pdf=render""}, {""id"": ""UniProtKB:A4YI89"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YI89 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-117_7edc9bbea68e	UniProtKB:A4YI89	pathwaymech:enables	RHEA:26560	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33472982|UniProtKB:A4YI89	This newer experimentally supported assignment supersedes the older exclusive Msed_0399 pathway assignment. The percentage is a kinetic/proteomic estimate, not a direct flux or knockout measurement.	"[{""reference_id"": ""UniProtKB:A4YI89"", ""source_assertion"": ""The current sequence entry identifies A4YI89 and its M. sedula DSM 5348 locus; sequence identity is distinct from the strength of catalytic annotation."", ""source_locator"": ""/results/3/primaryAccession; /genes; /organism; /sequence/value; selected primaryAccession=A4YI89""}, {""reference_id"": ""PMID:33472982"", ""source_assertion"": ""Msed_2001 supports crotonyl-CoA hydration; protein abundance and measured kinetics attribute about 86% of cell-extract hydratase capacity to it."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[5]/p[4]""}]"	"[{""id"": ""PMID:33472982"", ""source_sha256"": ""2247c350a1f9667908142b512fc4669bcfe7e8cf897087f0c4579beb7ff54961"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Convergent Evolution of a Promiscuous 3-Hydroxypropionyl-CoA Dehydratase/Crotonyl-CoA Hydratase in Crenarchaeota and Thaumarchaeota"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC7845616/""}, {""id"": ""UniProtKB:A4YI89"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YI89 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-118_83be6c171b12	UniProtKB:A4YGN2	pathwaymech:enables	RHEA:26456	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19429610|PMID:27771364|UniProtKB:A4YGN2	Native peptide identification and later recombinant Msed_1426 assays support the activity directly. The 2009 detailed recombinant experiment used S. tokodaii; the later selected-protein preparation required coexpression with Msed_1424, without positive two-hybrid evidence for an ACR/SSR complex.	"[{""reference_id"": ""UniProtKB:A4YGN2"", ""source_assertion"": ""The current sequence entry identifies A4YGN2 and its M. sedula DSM 5348 locus; sequence identity is distinct from the strength of catalytic annotation."", ""source_locator"": ""/results/4/primaryAccession; /genes; /organism; /sequence/value; selected primaryAccession=A4YGN2""}, {""reference_id"": ""PMID:19429610"", ""source_assertion"": ""Native M. sedula reductase peptides identify Msed_1426 at 100% identity and 73% coverage; detailed recombinant NADPH kinetics used S. tokodaii ST0480."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[3]/section[3]/p""}, {""reference_id"": ""PMID:27771364"", ""source_assertion"": ""Recombinant Msed_1426 was obtained after coexpression with Msed_1424, separated by gel filtration and assayed for acryloyl-CoA-dependent NADPH oxidation."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[4]/section[1]/section[4]/p""}]"	"[{""id"": ""PMID:19429610"", ""source_sha256"": ""f76c2395f75cbad5a381e360a7a179882bc65b405249ae438b2f55e676e85628"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""3-Hydroxypropionyl-Coenzyme A Dehydratase and Acryloyl-Coenzyme A Reductase, Enzymes of the Autotrophic 3-Hydroxypropionate/4-Hydroxybutyrate Cycle in the Sulfolobales ▿"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2704735/""}, {""id"": ""PMID:27771364"", ""source_sha256"": ""426c21ac77b49b5d82ca871d3d0eb4cd523b22454b4084fea626fc592febeedd"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Reaction Kinetic Analysis of the 3-Hydroxypropionate/4-Hydroxybutyrate CO 2 Fixation Cycle in Extremely Thermoacidophilic Archaea"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC5433351/?pdf=render""}, {""id"": ""UniProtKB:A4YGN2"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YGN2 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-119_ea017e8753be	UniProtKB:A4YDT1	pathwaymech:enables	RHEA:23129	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14676|PMID:23258541|UniProtKB:A4YDT1	A measured functional role with no claim of monomer sufficiency or an independently established assembly.	"[{""reference_id"": ""MetaCyc:ENZRXN-14676"", ""source_assertion"": ""The native enzyme-reaction object assigns this functional step to its linked protein."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/enzyme; /ptools-xml/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:A4YDT1"", ""source_assertion"": ""The current sequence entry identifies A4YDT1 and its M. sedula DSM 5348 locus; sequence identity is distinct from the strength of catalytic annotation."", ""source_locator"": ""/results/0/primaryAccession; /genes; /organism; /sequence/value; selected primaryAccession=A4YDT1""}, {""reference_id"": ""PMID:23258541"", ""source_assertion"": ""Recombinant Msed_0406 catalyzes ATP-dependent CoA ligation to 4-hydroxybutyrate, with a reported rate of 1.69 micromol/min/mg."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[2]/p""}]"	"[{""id"": ""MetaCyc:ENZRXN-14676"", ""source_sha256"": ""9dcbca40d81c321c6366c106e4ea2a07e77301cf334317dc100ea2f22cd57687"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14676 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14676""}, {""id"": ""PMID:23258541"", ""source_sha256"": ""816d414512128b83705dd41408ffdb0c0fa5fc4c09056687106e6057198d75c7"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Role of 4-Hydroxybutyrate-CoA Synthetase in the CO 2 Fixation Cycle in Thermoacidophilic Archaea *"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3567653/""}, {""id"": ""UniProtKB:A4YDT1"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YDT1 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-120_cf8373631e7b	UniProtKB:A4YGC7	pathwaymech:enables	RHEA:26531	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14678|PMID:24532060|UniProtKB:A4YGC7	The protein enables the reaction as a functional role; the apparent tetramer is retained as experimental context. The enzyme was less oxygen-sensitive than the clostridial homolog under the tested conditions.	"[{""reference_id"": ""MetaCyc:ENZRXN-14678"", ""source_assertion"": ""The native enzyme-reaction object assigns this functional step to its linked protein."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/enzyme; /ptools-xml/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:A4YGC7"", ""source_assertion"": ""The current sequence entry identifies A4YGC7 and its M. sedula DSM 5348 locus; sequence identity is distinct from the strength of catalytic annotation."", ""source_locator"": ""/results/23/primaryAccession; /genes; /organism; /sequence/value; selected primaryAccession=A4YGC7""}, {""reference_id"": ""PMID:24532060"", ""source_assertion"": ""Purified Msed_1321 supports 4-hydroxybutyryl-CoA dehydration. Its 221.5-kDa apparent mass relative to a 56.6-kDa subunit suggests a homotetramer."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[4]/section[1]/p[1]""}]"	"[{""id"": ""MetaCyc:ENZRXN-14678"", ""source_sha256"": ""7391ecc342f8f3120770538f94bf85d4e0ab1455894cad96d7c53526fc13f2e6"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14678 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14678""}, {""id"": ""PMID:24532060"", ""source_sha256"": ""e31d389454b3fa78e2ae08593a07fdb9772cb9f46411593f6fa86b8630913fa0"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Conversion of 4-Hydroxybutyrate to Acetyl Coenzyme A and Its Anapleurosis in the Metallosphaera sedula 3-Hydroxypropionate/4-Hydroxybutyrate Carbon Fixation Pathway"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3993168/""}, {""id"": ""UniProtKB:A4YGC7"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YGC7 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-121_bac6a958680a	UniProtKB:A4YGM9	pathwaymech:enables	RHEA:30800	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:32218776|UniProtKB:A4YGM9	The measured primary reassignment is retained separately from the older native Msed_0399-only assignment; no physical assembly or monomer sufficiency is asserted.	"[{""reference_id"": ""UniProtKB:A4YGM9"", ""source_assertion"": ""The current sequence entry identifies A4YGM9 and its M. sedula DSM 5348 locus; sequence identity is distinct from the strength of catalytic annotation."", ""source_locator"": ""/results/21/primaryAccession; /genes; /organism; /sequence/value; selected primaryAccession=A4YGM9""}, {""reference_id"": ""PMID:32218776"", ""source_assertion"": ""Recombinant Msed_1423 catalyzes NAD-dependent oxidation of (S)-3-hydroxybutyryl-CoA; the primary reassessment supports it as the main cycle dehydrogenase."", ""source_locator"": ""/article/body/sec[4]/p[4]""}]"	"[{""id"": ""PMID:32218776"", ""source_sha256"": ""6a86bad3966f1aa6c2d17b2a2383bd9a1184b762ff3901bae38b39cc52cc4f84"", ""source_version"": ""Original full-text JATS XML; acquired 2026-10-11"", ""title"": ""Enzymes Catalyzing Crotonyl-CoA Conversion to Acetoacetyl-CoA During the Autotrophic CO2 Fixation in Metallosphaera sedula"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7078158/fullTextXML""}, {""id"": ""UniProtKB:A4YGM9"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YGM9 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-122_46cb3a3f9c34	UniProtKB:A4YEH9	pathwaymech:enables	RHEA:21038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14681|PMID:24532060|UniProtKB:A4YEH9	Functional thiolase role in the complete four-enzyme reconstitution; the selected cleavage equation produces two acetyl-CoA molecules.	"[{""reference_id"": ""MetaCyc:ENZRXN-14681"", ""source_assertion"": ""The native enzyme-reaction object assigns this functional step to its linked protein."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/enzyme; /ptools-xml/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:A4YEH9"", ""source_assertion"": ""The current sequence entry identifies A4YEH9 and its M. sedula DSM 5348 locus; sequence identity is distinct from the strength of catalytic annotation."", ""source_locator"": ""/results/9/primaryAccession; /genes; /organism; /sequence/value; selected primaryAccession=A4YEH9""}, {""reference_id"": ""PMID:24532060"", ""source_assertion"": ""Purified Msed_0656 thiolase completes the reconstituted 4-hydroxybutyrate-to-acetyl-CoA module."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[4]/section[1]/p[2]; /html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[4]/section[1]/p[4]""}]"	"[{""id"": ""MetaCyc:ENZRXN-14681"", ""source_sha256"": ""2410756ad1fda20f900745c77bb2bff92f9f1cc0ef08a1839ed6f51f0d333168"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14681 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14681""}, {""id"": ""PMID:24532060"", ""source_sha256"": ""e31d389454b3fa78e2ae08593a07fdb9772cb9f46411593f6fa86b8630913fa0"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Conversion of 4-Hydroxybutyrate to Acetyl Coenzyme A and Its Anapleurosis in the Metallosphaera sedula 3-Hydroxypropionate/4-Hydroxybutyrate Carbon Fixation Pathway"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3993168/""}, {""id"": ""UniProtKB:A4YEH9"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YEH9 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-123_078d9183e239	UniProtKB:A4YDR9	pathwaymech:enables	RHEA:23129	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:23258541|UniProtKB:A4YDR9	An experimentally measured alternative activity, with weaker evidence for major cycle flux than Msed_0406; the two proteins are not assigned equal physiological contribution.	"[{""reference_id"": ""UniProtKB:A4YDR9"", ""source_assertion"": ""The current sequence entry identifies A4YDR9 and its M. sedula DSM 5348 locus; sequence identity is distinct from the strength of catalytic annotation."", ""source_locator"": ""/results/0/primaryAccession; /genes; /organism; /sequence/value; selected primaryAccession=A4YDR9""}, {""reference_id"": ""PMID:23258541"", ""source_assertion"": ""Recombinant Msed_0394 also ligates CoA to 4-hydroxybutyrate, at 0.22 micromol/min/mg in the reported comparison."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[2]/p""}]"	"[{""id"": ""PMID:23258541"", ""source_sha256"": ""816d414512128b83705dd41408ffdb0c0fa5fc4c09056687106e6057198d75c7"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Role of 4-Hydroxybutyrate-CoA Synthetase in the CO 2 Fixation Cycle in Thermoacidophilic Archaea *"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3567653/""}, {""id"": ""UniProtKB:A4YDR9"", ""source_sha256"": ""5d241ba92fba7d5614fb240583b52c3edfb47223c02c6674ec4918e3f1ade8ab"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YDR9 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0394+AND+organism_id%3A399549&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-124_07c6309d4769	UniProtKB:A4YDS4	pathwaymech:enables	RHEA:26560	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14679|PMID:24532060|UniProtKB:A4YDS4	A retained measured alternative. Later work identifies Msed_2001 and Msed_1423 as the principal hydratase and dehydrogenase, respectively; activity does not establish exclusive physiological responsibility.	"[{""reference_id"": ""MetaCyc:ENZRXN-14679"", ""source_assertion"": ""The native enzyme-reaction object assigns this functional step to its linked protein."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/enzyme; /ptools-xml/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:A4YDS4"", ""source_assertion"": ""The current sequence entry identifies A4YDS4 and its M. sedula DSM 5348 locus; sequence identity is distinct from the strength of catalytic annotation."", ""source_locator"": ""/results/6/primaryAccession; /genes; /organism; /sequence/value; selected primaryAccession=A4YDS4""}, {""reference_id"": ""PMID:24532060"", ""source_assertion"": ""The purified bifunctional Msed_0399 protein supports the crotonyl-CoA hydratase/(S)-3-hydroxybutyryl-CoA dehydrogenase steps in the reconstructed module."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[4]/section[1]/p[2]; /html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[4]/section[1]/p[4]""}]"	"[{""id"": ""MetaCyc:ENZRXN-14679"", ""source_sha256"": ""700bcb9901e205436818c1078ba06c8334092d04779da480cc57326c01bd20a0"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14679 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14679""}, {""id"": ""PMID:24532060"", ""source_sha256"": ""e31d389454b3fa78e2ae08593a07fdb9772cb9f46411593f6fa86b8630913fa0"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Conversion of 4-Hydroxybutyrate to Acetyl Coenzyme A and Its Anapleurosis in the Metallosphaera sedula 3-Hydroxypropionate/4-Hydroxybutyrate Carbon Fixation Pathway"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3993168/""}, {""id"": ""UniProtKB:A4YDS4"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YDS4 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-125_f44183a1f9c0	UniProtKB:A4YDS4	pathwaymech:enables	RHEA:30800	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14680|PMID:24532060|UniProtKB:A4YDS4	A retained measured alternative. Later work identifies Msed_2001 and Msed_1423 as the principal hydratase and dehydrogenase, respectively; activity does not establish exclusive physiological responsibility.	"[{""reference_id"": ""MetaCyc:ENZRXN-14680"", ""source_assertion"": ""The native enzyme-reaction object assigns this functional step to its linked protein."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/enzyme; /ptools-xml/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:A4YDS4"", ""source_assertion"": ""The current sequence entry identifies A4YDS4 and its M. sedula DSM 5348 locus; sequence identity is distinct from the strength of catalytic annotation."", ""source_locator"": ""/results/6/primaryAccession; /genes; /organism; /sequence/value; selected primaryAccession=A4YDS4""}, {""reference_id"": ""PMID:24532060"", ""source_assertion"": ""The purified bifunctional Msed_0399 protein supports the crotonyl-CoA hydratase/(S)-3-hydroxybutyryl-CoA dehydrogenase steps in the reconstructed module."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[4]/section[1]/p[2]; /html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[4]/section[1]/p[4]""}]"	"[{""id"": ""MetaCyc:ENZRXN-14680"", ""source_sha256"": ""112206108b682923cf09d1704cb6e49de3feb7e649daef23b11b3e7073616674"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14680 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14680""}, {""id"": ""PMID:24532060"", ""source_sha256"": ""e31d389454b3fa78e2ae08593a07fdb9772cb9f46411593f6fa86b8630913fa0"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Conversion of 4-Hydroxybutyrate to Acetyl Coenzyme A and Its Anapleurosis in the Metallosphaera sedula 3-Hydroxypropionate/4-Hydroxybutyrate Carbon Fixation Pathway"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3993168/""}, {""id"": ""UniProtKB:A4YDS4"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YDS4 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-126_e646b1ac60df	UniProtKB:A4YDL1	pathwaymech:enables	RHEA:26560	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:32218776|UniProtKB:A4YDL1	Alternative measured hydratase activity, not an equally supported principal cycle enzyme or a defined assembly. Later proteomic/kinetic estimates favor Msed_2001.	"[{""reference_id"": ""UniProtKB:A4YDL1"", ""source_assertion"": ""The current sequence entry identifies A4YDL1 and its M. sedula DSM 5348 locus; sequence identity is distinct from the strength of catalytic annotation."", ""source_locator"": ""/results/7/primaryAccession; /genes; /organism; /sequence/value; selected primaryAccession=A4YDL1""}, {""reference_id"": ""PMID:32218776"", ""source_assertion"": ""Purified recombinant Msed_0336 has crotonyl-CoA hydratase activity."", ""source_locator"": ""/article/body/sec[3]/sec[4]/p""}]"	"[{""id"": ""PMID:32218776"", ""source_sha256"": ""6a86bad3966f1aa6c2d17b2a2383bd9a1184b762ff3901bae38b39cc52cc4f84"", ""source_version"": ""Original full-text JATS XML; acquired 2026-10-11"", ""title"": ""Enzymes Catalyzing Crotonyl-CoA Conversion to Acetoacetyl-CoA During the Autotrophic CO2 Fixation in Metallosphaera sedula"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7078158/fullTextXML""}, {""id"": ""UniProtKB:A4YDL1"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YDL1 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-127_e8e1ef7077fc	UniProtKB:A4YDQ9	pathwaymech:enables	RHEA:26560	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:32218776|UniProtKB:A4YDQ9	Alternative measured hydratase activity, not an equally supported principal cycle enzyme or a defined assembly. Later proteomic/kinetic estimates favor Msed_2001.	"[{""reference_id"": ""UniProtKB:A4YDQ9"", ""source_assertion"": ""The current sequence entry identifies A4YDQ9 and its M. sedula DSM 5348 locus; sequence identity is distinct from the strength of catalytic annotation."", ""source_locator"": ""/results/17/primaryAccession; /genes; /organism; /sequence/value; selected primaryAccession=A4YDQ9""}, {""reference_id"": ""PMID:32218776"", ""source_assertion"": ""Purified recombinant Msed_0384 has crotonyl-CoA hydratase activity."", ""source_locator"": ""/article/body/sec[3]/sec[4]/p""}]"	"[{""id"": ""PMID:32218776"", ""source_sha256"": ""6a86bad3966f1aa6c2d17b2a2383bd9a1184b762ff3901bae38b39cc52cc4f84"", ""source_version"": ""Original full-text JATS XML; acquired 2026-10-11"", ""title"": ""Enzymes Catalyzing Crotonyl-CoA Conversion to Acetoacetyl-CoA During the Autotrophic CO2 Fixation in Metallosphaera sedula"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7078158/fullTextXML""}, {""id"": ""UniProtKB:A4YDQ9"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YDQ9 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-128_b8be4f35c9e5	UniProtKB:A4YDR4	pathwaymech:enables	RHEA:30800	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:32218776|UniProtKB:A4YDR4	Measured alternative activity; genomic context favors beta-oxidation rather than a dominant HP/HB cycle role. No obligatory cycle flux or assembly is asserted.	"[{""reference_id"": ""UniProtKB:A4YDR4"", ""source_assertion"": ""The current sequence entry identifies A4YDR4 and its M. sedula DSM 5348 locus; sequence identity is distinct from the strength of catalytic annotation."", ""source_locator"": ""/results/14/primaryAccession; /genes; /organism; /sequence/value; selected primaryAccession=A4YDR4""}, {""reference_id"": ""PMID:32218776"", ""source_assertion"": ""Recombinant Msed_0389 oxidizes (S)-3-hydroxybutyryl-CoA with NAD; its likely physiological role differs from the cycle-associated Msed_1423."", ""source_locator"": ""/article/body/sec[3]/sec[3]/p""}]"	"[{""id"": ""PMID:32218776"", ""source_sha256"": ""6a86bad3966f1aa6c2d17b2a2383bd9a1184b762ff3901bae38b39cc52cc4f84"", ""source_version"": ""Original full-text JATS XML; acquired 2026-10-11"", ""title"": ""Enzymes Catalyzing Crotonyl-CoA Conversion to Acetoacetyl-CoA During the Autotrophic CO2 Fixation in Metallosphaera sedula"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7078158/fullTextXML""}, {""id"": ""UniProtKB:A4YDR4"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YDR4 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-129_3d3cd9fe17d6	UniProtKB:A4YD23	pathwaymech:has_cofactor	CHEBI:57586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:BIOTIN|NCBIProtein:AAO15573.1|PMID:12581213	Covalently attached biotin prosthetic group on the carrier subunit, not a free biotin reactant in the net carboxylation equation.	"[{""reference_id"": ""MetaCyc:BIOTIN"", ""source_assertion"": ""The native biotin structure is cross-referenced to CHEBI:57586."", ""source_locator"": ""/ptools-xml/Compound/dblink[dblink-db=\""CHEBI\""]; /ptools-xml/Compound/inchi""}, {""reference_id"": ""PMID:12581213"", ""source_assertion"": ""Biotin staining and subunit sequencing identify the small biotin carrier."", ""source_locator"": ""Results, Carboxylase activity and biotin-containing proteins; Figure 2; Purification and molecular properties, N-terminal sequencing""}, {""reference_id"": ""NCBIProtein:AAO15573.1"", ""source_assertion"": ""Original deposited biotin-carrier CDS translation exactly matches A4YD23."", ""source_locator"": ""FT CDS /protein_id=\""AAO15573.1\""; /product; /translation""}]"	"[{""id"": ""MetaCyc:BIOTIN"", ""source_sha256"": ""040619e40fc3fe512910daad8763b74ba75f885d44f94590b5d3302fa37ead00"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc BIOTIN native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:BIOTIN""}, {""id"": ""NCBIProtein:AAO15573.1"", ""source_sha256"": ""c6bcfb14b63d7f569eb03c97c6992a81d6678d717e85dd1604b60fda5bf6b21e"", ""source_version"": ""Original ENA EMBL nucleotide record with CDS translation"", ""title"": ""Original archaeal carboxylase CDS AAO15573.1"", ""url"": ""https://www.ebi.ac.uk/ena/browser/api/embl/AF461116?download=false""}, {""id"": ""PMID:12581213"", ""source_sha256"": ""1bf5ef7240acd43a7d99617eb7c06fcf6f72216af1d90781686c1959ea5a3baf"", ""source_version"": ""2003; retained tool-rendered public publisher full text; hash covers JSON tool representation, NOT original HTML"", ""title"": ""Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/full/10.1046/j.1432-1033.2003.03434.x""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-130_cc4eea5b6280	MetaCyc:CPLX-7580	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12581213	Direct divalent-ion dependence and MgATP assay support. Other divalent ions partly substitute; this does not specify a permanent bound-magnesium stoichiometry.	"[{""reference_id"": ""PMID:12581213"", ""source_assertion"": ""Omitting divalent ions left less than 1% activity; magnesium restored the MgATP-dependent assay."", ""source_locator"": ""Results, Catalytic properties; Table 2""}]"	"[{""id"": ""PMID:12581213"", ""source_sha256"": ""1bf5ef7240acd43a7d99617eb7c06fcf6f72216af1d90781686c1959ea5a3baf"", ""source_version"": ""2003; retained tool-rendered public publisher full text; hash covers JSON tool representation, NOT original HTML"", ""title"": ""Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/full/10.1046/j.1432-1033.2003.03434.x""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-131_ada30dbb4363	MetaCyc:CPLX-7948	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19684143	Two zinc sites per monomer are inferred from metal content and conserved motifs; adding zinc did not stimulate the already loaded preparation.	"[{""reference_id"": ""PMID:19684143"", ""source_assertion"": ""Purified Msed_1424 contained 1.9 zinc atoms per monomer; EDTA did not inhibit or inactivate the enzyme under the tested conditions."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[4]/section[1]/p[3]""}]"	"[{""id"": ""PMID:19684143"", ""source_sha256"": ""007d86b186a3da978f6ca10256d101d930828314380fa1071fafbeefa0ee6807"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Malonic Semialdehyde Reductase, Succinic Semialdehyde Reductase, and Succinyl-Coenzyme A Reductase from Metallosphaera sedula : Enzymes of the Autotrophic 3-Hydroxypropionate/4-Hydroxybutyrate Cycle in Sulfolobales ▿"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2753041/""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-132_ba8167ca1e8b	UniProtKB:A4YGN2	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:A4YGN2	The zinc requirement is inferred for the selected M. sedula protein; the detailed recombinant experiment used the S. tokodaii homolog.	"[{""reference_id"": ""UniProtKB:A4YGN2"", ""source_assertion"": ""UniProt annotates zinc as cofactor with ECO:0000250 to S. tokodaii Q975C8. This is a similarity-based assignment for M. sedula."", ""source_locator"": ""/results/4/comments/2/cofactors/0; selected primaryAccession=A4YGN2""}]"	"[{""id"": ""UniProtKB:A4YGN2"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YGN2 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-133_4cd61c275b67	MetaCyc:CPLX-8530	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14672|PMID:22752162	One of the experimentally tested alternative activating metals, not evidence that all three bind simultaneously or are equally physiological.	"[{""reference_id"": ""PMID:22752162"", ""source_assertion"": ""Msed_0639 epimerase was activated by Ni(2+), Co(2+) and Mg(2+) in vitro; the physiological metal was not established."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[1]/p""}, {""reference_id"": ""MetaCyc:ENZRXN-14672"", ""source_assertion"": ""The native enzyme-reaction annotation lists the tested divalent-ion cofactors."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/cofactor""}]"	"[{""id"": ""MetaCyc:ENZRXN-14672"", ""source_sha256"": ""33ccf23f4519da04c629885003fbf33e28466555f0dcee8c4cf2eb900f8edc85"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14672 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14672""}, {""id"": ""PMID:22752162"", ""source_sha256"": ""3a27b76d333daa5dc398163e3346114c52c1a895c02a62a637716000dfd8871b"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Epimerase (Msed_0639) and Mutase (Msed_0638 and Msed_2055) Convert ( S )-Methylmalonyl-Coenzyme A (CoA) to Succinyl-CoA in the Metallosphaera sedula 3-Hydroxypropionate/4-Hydroxybutyrate Cycle"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3416614/""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-134_f78a2676c8e4	MetaCyc:CPLX-8530	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14672|PMID:22752162	One of the experimentally tested alternative activating metals, not evidence that all three bind simultaneously or are equally physiological.	"[{""reference_id"": ""PMID:22752162"", ""source_assertion"": ""Msed_0639 epimerase was activated by Ni(2+), Co(2+) and Mg(2+) in vitro; the physiological metal was not established."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[1]/p""}, {""reference_id"": ""MetaCyc:ENZRXN-14672"", ""source_assertion"": ""The native enzyme-reaction annotation lists the tested divalent-ion cofactors."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/cofactor""}]"	"[{""id"": ""MetaCyc:ENZRXN-14672"", ""source_sha256"": ""33ccf23f4519da04c629885003fbf33e28466555f0dcee8c4cf2eb900f8edc85"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14672 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14672""}, {""id"": ""PMID:22752162"", ""source_sha256"": ""3a27b76d333daa5dc398163e3346114c52c1a895c02a62a637716000dfd8871b"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Epimerase (Msed_0639) and Mutase (Msed_0638 and Msed_2055) Convert ( S )-Methylmalonyl-Coenzyme A (CoA) to Succinyl-CoA in the Metallosphaera sedula 3-Hydroxypropionate/4-Hydroxybutyrate Cycle"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3416614/""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-135_227c21ddc8f6	MetaCyc:CPLX-8530	pathwaymech:has_cofactor	CHEBI:49786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14672|PMID:22752162	One of the experimentally tested alternative activating metals, not evidence that all three bind simultaneously or are equally physiological.	"[{""reference_id"": ""PMID:22752162"", ""source_assertion"": ""Msed_0639 epimerase was activated by Ni(2+), Co(2+) and Mg(2+) in vitro; the physiological metal was not established."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[1]/p""}, {""reference_id"": ""MetaCyc:ENZRXN-14672"", ""source_assertion"": ""The native enzyme-reaction annotation lists the tested divalent-ion cofactors."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/cofactor""}]"	"[{""id"": ""MetaCyc:ENZRXN-14672"", ""source_sha256"": ""33ccf23f4519da04c629885003fbf33e28466555f0dcee8c4cf2eb900f8edc85"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14672 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14672""}, {""id"": ""PMID:22752162"", ""source_sha256"": ""3a27b76d333daa5dc398163e3346114c52c1a895c02a62a637716000dfd8871b"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Epimerase (Msed_0639) and Mutase (Msed_0638 and Msed_2055) Convert ( S )-Methylmalonyl-Coenzyme A (CoA) to Succinyl-CoA in the Metallosphaera sedula 3-Hydroxypropionate/4-Hydroxybutyrate Cycle"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3416614/""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-136_c91d32804dd3	MetaCyc:CPLX-7576	pathwaymech:has_cofactor	CHEBI:18408	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14673|PMID:22752162	Adenosylcobalamin belongs to the mutase complex, rather than a free cobalt-ion substitution.	"[{""reference_id"": ""MetaCyc:ENZRXN-14673"", ""source_assertion"": ""The native mutase annotation lists adenosylcobalamin as cofactor."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/cofactor""}, {""reference_id"": ""PMID:22752162"", ""source_assertion"": ""Msed_2055 is the coenzyme-B12-binding subunit required with catalytic Msed_0638 for active mutase."", ""source_locator"": ""/html/body/div[2]/div[2]/div/div[1]/div/div[2]/main/article/section[2]/section/section[4]/section[3]/p[4]""}]"	"[{""id"": ""MetaCyc:ENZRXN-14673"", ""source_sha256"": ""d09f52a59682d3f216ea7f43772b2cee8c6850f5e482c3de370b7c8190639613"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14673 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14673""}, {""id"": ""PMID:22752162"", ""source_sha256"": ""3a27b76d333daa5dc398163e3346114c52c1a895c02a62a637716000dfd8871b"", ""source_version"": ""Original full-text PMC HTML; acquired 2026-10-11"", ""title"": ""Epimerase (Msed_0639) and Mutase (Msed_0638 and Msed_2055) Convert ( S )-Methylmalonyl-Coenzyme A (CoA) to Succinyl-CoA in the Metallosphaera sedula 3-Hydroxypropionate/4-Hydroxybutyrate Cycle"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3416614/""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-137_f5f67d2d66b5	UniProtKB:A4YGC7	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-14678|MetaCyc:FAD	Curated database cofactor identity; the cluster identifier is not an experimental oxidation-state determination. The cited 2007 discovery paper was not available as inspected full text, and the 2014 activity assay is not treated as direct measurement of cofactor occupancy.	"[{""reference_id"": ""MetaCyc:ENZRXN-14678"", ""source_assertion"": ""The curated native 4-hydroxybutyryl-CoA dehydratase annotation explicitly lists FAD and a [4Fe-4S] cluster."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/cofactor""}, {""reference_id"": ""MetaCyc:FAD"", ""source_assertion"": ""The original native cofactor object cross-references CHEBI:57692."", ""source_locator"": ""/ptools-xml/Compound/dblink[dblink-db=\""CHEBI\""]""}]"	"[{""id"": ""MetaCyc:ENZRXN-14678"", ""source_sha256"": ""7391ecc342f8f3120770538f94bf85d4e0ab1455894cad96d7c53526fc13f2e6"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14678 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14678""}, {""id"": ""MetaCyc:FAD"", ""source_sha256"": ""f139cd59cc3864afb1aac879436efd190febdaca939f110f99056fd36147cdac"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc FAD native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:FAD""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-138_7251aa7a5861	UniProtKB:A4YGC7	pathwaymech:has_cofactor	CHEBI:33725	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-7|MetaCyc:ENZRXN-14678	Curated database cofactor identity; the cluster identifier is not an experimental oxidation-state determination. The cited 2007 discovery paper was not available as inspected full text, and the 2014 activity assay is not treated as direct measurement of cofactor occupancy.	"[{""reference_id"": ""MetaCyc:ENZRXN-14678"", ""source_assertion"": ""The curated native 4-hydroxybutyryl-CoA dehydratase annotation explicitly lists FAD and a [4Fe-4S] cluster."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/cofactor""}, {""reference_id"": ""MetaCyc:CPD-7"", ""source_assertion"": ""The original native cofactor object cross-references CHEBI:33725."", ""source_locator"": ""/ptools-xml/Compound/dblink[dblink-db=\""CHEBI\""]""}]"	"[{""id"": ""MetaCyc:CPD-7"", ""source_sha256"": ""839cc4c0633dd1ec312a5d17879001f2d2c6a7af61f00cb6c1675e17c655e89c"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc CPD-7 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-7""}, {""id"": ""MetaCyc:ENZRXN-14678"", ""source_sha256"": ""7391ecc342f8f3120770538f94bf85d4e0ab1455894cad96d7c53526fc13f2e6"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ENZRXN-14678 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-14678""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-139_d03f8708e3f0	UniProtKB:A4YDT1	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:A4YDT1	Similarity-based alternative divalent cofactor annotation; no selected-protein binding stoichiometry is asserted.	"[{""reference_id"": ""UniProtKB:A4YDT1"", ""source_assertion"": ""UniProt assigns this divalent cofactor by ECO:0000250 similarity to Q08AH3, rather than a direct selected-protein metal-binding experiment."", ""source_locator"": ""/results/0/comments/5/cofactors/0; selected primaryAccession=A4YDT1""}]"	"[{""id"": ""UniProtKB:A4YDT1"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YDT1 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-140_043bc0c07d7f	UniProtKB:A4YDT1	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:A4YDT1	Similarity-based alternative divalent cofactor annotation; no selected-protein binding stoichiometry is asserted.	"[{""reference_id"": ""UniProtKB:A4YDT1"", ""source_assertion"": ""UniProt assigns this divalent cofactor by ECO:0000250 similarity to Q08AH3, rather than a direct selected-protein metal-binding experiment."", ""source_locator"": ""/results/0/comments/5/cofactors/1; selected primaryAccession=A4YDT1""}]"	"[{""id"": ""UniProtKB:A4YDT1"", ""source_sha256"": ""58b3e92a257298fb486ccebf608887b00749ff4009825ebc638118a197f02985"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YDT1 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0147+OR+gene%3AMsed_0148+OR+gene%3AMsed_1375+OR+gene%3AMsed_0709+OR+gene%3AMsed_1993+OR+gene%3AMsed_1456+OR+gene%3AMsed_2001+OR+gene%3AMsed_1426+OR+gene%3AMsed_0639+OR+gene%3AMsed_0638+OR+gene%3AMsed_2055+OR+gene%3AMsed_1424+OR+gene%3AMsed_1422+OR+gene%3AMsed_0406+OR+gene%3AMsed_1321+OR+gene%3AMsed_1220+OR+gene%3AMsed_0399+OR+gene%3AMsed_0336+OR+gene%3AMsed_0384+OR+gene%3AMsed_0385+OR+gene%3AMsed_0566+OR+gene%3AMsed_1423+OR+gene%3AMsed_0389+OR+gene%3AMsed_0656&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-141_3bbc52f0449a	UniProtKB:A4YDR9	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:A4YDR9	Similarity-based alternative divalent cofactor annotation; no selected-protein binding stoichiometry is asserted.	"[{""reference_id"": ""UniProtKB:A4YDR9"", ""source_assertion"": ""UniProt assigns this divalent cofactor by ECO:0000250 similarity to Q08AH3, rather than a direct selected-protein metal-binding experiment."", ""source_locator"": ""/results/0/comments/5/cofactors/0; selected primaryAccession=A4YDR9""}]"	"[{""id"": ""UniProtKB:A4YDR9"", ""source_sha256"": ""5d241ba92fba7d5614fb240583b52c3edfb47223c02c6674ec4918e3f1ade8ab"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YDR9 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0394+AND+organism_id%3A399549&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-142_6a2c2cf849d9	UniProtKB:A4YDR9	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:A4YDR9	Similarity-based alternative divalent cofactor annotation; no selected-protein binding stoichiometry is asserted.	"[{""reference_id"": ""UniProtKB:A4YDR9"", ""source_assertion"": ""UniProt assigns this divalent cofactor by ECO:0000250 similarity to Q08AH3, rather than a direct selected-protein metal-binding experiment."", ""source_locator"": ""/results/0/comments/5/cofactors/1; selected primaryAccession=A4YDR9""}]"	"[{""id"": ""UniProtKB:A4YDR9"", ""source_sha256"": ""5d241ba92fba7d5614fb240583b52c3edfb47223c02c6674ec4918e3f1ade8ab"", ""source_version"": ""2026_03 (2026-09-02); hash of retained complete multi-entry query response, selected by primaryAccession"", ""title"": ""UniProtKB A4YDR9 original complete-entry search response"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=gene%3AMsed_0394+AND+organism_id%3A399549&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-143_993dd6107b07	CHEBI:57384	pathwaymech:inhibits	MetaCyc:CPLX-7580	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12581213	In vitro inhibition under the reported MgATP assay conditions. An intracellular regulatory effect at physiological concentrations is not established.	"[{""reference_id"": ""PMID:12581213"", ""source_assertion"": ""0.5 mM malonyl-CoA left 20%/40% acetyl-/propionyl-carboxylase activity."", ""source_locator"": ""Results, Catalytic properties; Table 2""}]"	"[{""id"": ""PMID:12581213"", ""source_sha256"": ""1bf5ef7240acd43a7d99617eb7c06fcf6f72216af1d90781686c1959ea5a3baf"", ""source_version"": ""2003; retained tool-rendered public publisher full text; hash covers JSON tool representation, NOT original HTML"", ""title"": ""Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/full/10.1046/j.1432-1033.2003.03434.x""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-144_96e67c3d8aeb	CHEBI:57292	pathwaymech:inhibits	MetaCyc:CPLX-7580	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12581213	In vitro inhibition under the reported MgATP assay conditions. An intracellular regulatory effect at physiological concentrations is not established.	"[{""reference_id"": ""PMID:12581213"", ""source_assertion"": ""0.5 mM succinyl-CoA left 50%/80% activity."", ""source_locator"": ""Results, Catalytic properties; Table 2""}]"	"[{""id"": ""PMID:12581213"", ""source_sha256"": ""1bf5ef7240acd43a7d99617eb7c06fcf6f72216af1d90781686c1959ea5a3baf"", ""source_version"": ""2003; retained tool-rendered public publisher full text; hash covers JSON tool representation, NOT original HTML"", ""title"": ""Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/full/10.1046/j.1432-1033.2003.03434.x""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-145_9214e4895366	CHEBI:57287	pathwaymech:inhibits	MetaCyc:CPLX-7580	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12581213	In vitro inhibition under the reported MgATP assay conditions. An intracellular regulatory effect at physiological concentrations is not established.	"[{""reference_id"": ""PMID:12581213"", ""source_assertion"": ""1 mM CoA left 60%/80% activity."", ""source_locator"": ""Results, Catalytic properties; Table 2""}]"	"[{""id"": ""PMID:12581213"", ""source_sha256"": ""1bf5ef7240acd43a7d99617eb7c06fcf6f72216af1d90781686c1959ea5a3baf"", ""source_version"": ""2003; retained tool-rendered public publisher full text; hash covers JSON tool representation, NOT original HTML"", ""title"": ""Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/full/10.1046/j.1432-1033.2003.03434.x""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-146_13b98fc3d847	CHEBI:456216	pathwaymech:inhibits	MetaCyc:CPLX-7580	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12581213	In vitro inhibition under the reported MgATP assay conditions. An intracellular regulatory effect at physiological concentrations is not established.	"[{""reference_id"": ""PMID:12581213"", ""source_assertion"": ""5 mM ADP left 20%/20% activity."", ""source_locator"": ""Results, Catalytic properties; Table 2""}]"	"[{""id"": ""PMID:12581213"", ""source_sha256"": ""1bf5ef7240acd43a7d99617eb7c06fcf6f72216af1d90781686c1959ea5a3baf"", ""source_version"": ""2003; retained tool-rendered public publisher full text; hash covers JSON tool representation, NOT original HTML"", ""title"": ""Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula"", ""url"": ""https://febs.onlinelibrary.wiley.com/doi/full/10.1046/j.1432-1033.2003.03434.x""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-147_5ba18166ce0b	RHEA:11309	RO:0002413	RHEA:26448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11309|RHEA:26448	Shared CHEBI:57384 supplies material continuity in the source-defined cycle; the graph does not assert that this is the only metabolic fate of the intermediate.	"[{""reference_id"": ""RHEA:11309"", ""source_assertion"": ""The directed reaction produces CHEBI:57384 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/11309/rh:products; http://rdf.rhea-db.org/11308_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_11308_compound_5125/rh:compound -> http://rdf.rhea-db.org/Compound_5125/rh:chebi""}, {""reference_id"": ""RHEA:26448"", ""source_assertion"": ""The directed reaction consumes CHEBI:57384 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448/rh:substrates; http://rdf.rhea-db.org/26446_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26446_compound_5125/rh:compound -> http://rdf.rhea-db.org/Compound_5125/rh:chebi""}]"	"[{""id"": ""RHEA:11309"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 11309 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26448 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-148_a0805a366753	RHEA:26448	RO:0002413	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440|RHEA:26448	Shared CHEBI:33190 supplies material continuity in the source-defined cycle; the graph does not assert that this is the only metabolic fate of the intermediate.	"[{""reference_id"": ""RHEA:26448"", ""source_assertion"": ""The directed reaction produces CHEBI:33190 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26448/rh:products; http://rdf.rhea-db.org/26446_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26446_compound_5274/rh:compound -> http://rdf.rhea-db.org/Compound_5274/rh:chebi""}, {""reference_id"": ""RHEA:26440"", ""source_assertion"": ""The directed reaction consumes CHEBI:33190 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440/rh:substrates; http://rdf.rhea-db.org/26438_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26438_compound_5274/rh:compound -> http://rdf.rhea-db.org/Compound_5274/rh:chebi""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26440 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26448"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26448 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-149_3d44c793d216	RHEA:26440	RO:0002413	RHEA:26535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440|RHEA:26535	Shared CHEBI:16510 supplies material continuity in the source-defined cycle; the graph does not assert that this is the only metabolic fate of the intermediate.	"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""The directed reaction produces CHEBI:16510 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440/rh:products; http://rdf.rhea-db.org/26438_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26438_compound_3378/rh:compound -> http://rdf.rhea-db.org/Compound_3378/rh:chebi""}, {""reference_id"": ""RHEA:26535"", ""source_assertion"": ""The directed reaction consumes CHEBI:16510 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535/rh:substrates; http://rdf.rhea-db.org/26534_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26534_compound_3378/rh:compound -> http://rdf.rhea-db.org/Compound_3378/rh:chebi""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26440 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26535 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-150_94bd2a0ed79d	RHEA:26535	RO:0002413	RHEA:26519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26519|RHEA:26535	Shared CHEBI:58528 supplies material continuity in the source-defined cycle; the graph does not assert that this is the only metabolic fate of the intermediate.	"[{""reference_id"": ""RHEA:26535"", ""source_assertion"": ""The directed reaction produces CHEBI:58528 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26535/rh:products; http://rdf.rhea-db.org/26534_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26534_compound_6030/rh:compound -> http://rdf.rhea-db.org/Compound_6030/rh:chebi""}, {""reference_id"": ""RHEA:26519"", ""source_assertion"": ""The directed reaction consumes CHEBI:58528 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26519/rh:substrates; http://rdf.rhea-db.org/26518_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26518_compound_6030/rh:compound -> http://rdf.rhea-db.org/Compound_6030/rh:chebi""}]"	"[{""id"": ""RHEA:26519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26519 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26535"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26535 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-151_855a147e4b52	RHEA:26519	RO:0002413	RHEA:26456	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26456|RHEA:26519	Shared CHEBI:57367 supplies material continuity in the source-defined cycle; the graph does not assert that this is the only metabolic fate of the intermediate.	"[{""reference_id"": ""RHEA:26519"", ""source_assertion"": ""The directed reaction produces CHEBI:57367 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26519/rh:products; http://rdf.rhea-db.org/26518_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26518_compound_2006/rh:compound -> http://rdf.rhea-db.org/Compound_2006/rh:chebi""}, {""reference_id"": ""RHEA:26456"", ""source_assertion"": ""The directed reaction consumes CHEBI:57367 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456/rh:substrates; http://rdf.rhea-db.org/26454_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26454_compound_2006/rh:compound -> http://rdf.rhea-db.org/Compound_2006/rh:chebi""}]"	"[{""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26456 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26519"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26519 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-152_0d2d607e069f	RHEA:26456	RO:0002413	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23721|RHEA:26456	Shared CHEBI:57392 supplies material continuity in the source-defined cycle; the graph does not assert that this is the only metabolic fate of the intermediate.	"[{""reference_id"": ""RHEA:26456"", ""source_assertion"": ""The directed reaction produces CHEBI:57392 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26456/rh:products; http://rdf.rhea-db.org/26454_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26454_compound_3421/rh:compound -> http://rdf.rhea-db.org/Compound_3421/rh:chebi""}, {""reference_id"": ""RHEA:23721"", ""source_assertion"": ""The directed reaction consumes CHEBI:57392 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23721/rh:substrates; http://rdf.rhea-db.org/23720_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_23720_compound_3421/rh:compound -> http://rdf.rhea-db.org/Compound_3421/rh:chebi""}]"	"[{""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23721 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26456"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26456 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-153_46275c61226b	RHEA:23721	RO:0002413	RHEA:20555	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20555|RHEA:23721	Shared CHEBI:57327 supplies material continuity in the source-defined cycle; the graph does not assert that this is the only metabolic fate of the intermediate.	"[{""reference_id"": ""RHEA:23721"", ""source_assertion"": ""The directed reaction produces CHEBI:57327 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23721/rh:products; http://rdf.rhea-db.org/23720_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_23720_compound_2780/rh:compound -> http://rdf.rhea-db.org/Compound_2780/rh:chebi""}, {""reference_id"": ""RHEA:20555"", ""source_assertion"": ""The directed reaction consumes CHEBI:57327 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/20555/rh:substrates; http://rdf.rhea-db.org/20553_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_20553_compound_2780/rh:compound -> http://rdf.rhea-db.org/Compound_2780/rh:chebi""}]"	"[{""id"": ""RHEA:20555"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 20555 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23721 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-154_405cdf9c35f3	RHEA:20555	RO:0002413	RHEA:22889	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20555|RHEA:22889	Shared CHEBI:57326 supplies material continuity in the source-defined cycle; the graph does not assert that this is the only metabolic fate of the intermediate.	"[{""reference_id"": ""RHEA:20555"", ""source_assertion"": ""The directed reaction produces CHEBI:57326 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/20555/rh:products; http://rdf.rhea-db.org/20553_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_20553_compound_1391/rh:compound -> http://rdf.rhea-db.org/Compound_1391/rh:chebi""}, {""reference_id"": ""RHEA:22889"", ""source_assertion"": ""The directed reaction consumes CHEBI:57326 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22889/rh:substrates; http://rdf.rhea-db.org/22888_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_22888_compound_1391/rh:compound -> http://rdf.rhea-db.org/Compound_1391/rh:chebi""}]"	"[{""id"": ""RHEA:20555"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 20555 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:22889"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 22889 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-155_0cf3530390cb	RHEA:22889	RO:0002413	RHEA:26452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22889|RHEA:26452	Shared CHEBI:57292 supplies material continuity in the source-defined cycle; the graph does not assert that this is the only metabolic fate of the intermediate.	"[{""reference_id"": ""RHEA:22889"", ""source_assertion"": ""The directed reaction produces CHEBI:57292 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/22889/rh:products; http://rdf.rhea-db.org/22888_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_22888_compound_4684/rh:compound -> http://rdf.rhea-db.org/Compound_4684/rh:chebi""}, {""reference_id"": ""RHEA:26452"", ""source_assertion"": ""The directed reaction consumes CHEBI:57292 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26452/rh:substrates; http://rdf.rhea-db.org/26450_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26450_compound_4684/rh:compound -> http://rdf.rhea-db.org/Compound_4684/rh:chebi""}]"	"[{""id"": ""RHEA:22889"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 22889 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26452"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26452 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-156_1c3e7fc33d81	RHEA:26452	RO:0002413	RHEA:26383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26383|RHEA:26452	Shared CHEBI:57706 supplies material continuity in the source-defined cycle; the graph does not assert that this is the only metabolic fate of the intermediate.	"[{""reference_id"": ""RHEA:26452"", ""source_assertion"": ""The directed reaction produces CHEBI:57706 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26452/rh:products; http://rdf.rhea-db.org/26450_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26450_compound_4279/rh:compound -> http://rdf.rhea-db.org/Compound_4279/rh:chebi""}, {""reference_id"": ""RHEA:26383"", ""source_assertion"": ""The directed reaction consumes CHEBI:57706 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26383/rh:substrates; http://rdf.rhea-db.org/26381_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26381_compound_4279/rh:compound -> http://rdf.rhea-db.org/Compound_4279/rh:chebi""}]"	"[{""id"": ""RHEA:26383"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26383 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26452"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26452 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-157_11d2c56d59d4	RHEA:26383	RO:0002413	RHEA:23129	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23129|RHEA:26383	Shared CHEBI:16724 supplies material continuity in the source-defined cycle; the graph does not assert that this is the only metabolic fate of the intermediate.	"[{""reference_id"": ""RHEA:26383"", ""source_assertion"": ""The directed reaction produces CHEBI:16724 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26383/rh:products; http://rdf.rhea-db.org/26381_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26381_compound_5278/rh:compound -> http://rdf.rhea-db.org/Compound_5278/rh:chebi""}, {""reference_id"": ""RHEA:23129"", ""source_assertion"": ""The directed reaction consumes CHEBI:16724 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23129/rh:substrates; http://rdf.rhea-db.org/23128_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_23128_compound_5278/rh:compound -> http://rdf.rhea-db.org/Compound_5278/rh:chebi""}]"	"[{""id"": ""RHEA:23129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23129 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26383"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26383 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-158_3606bb6e9597	RHEA:23129	RO:0002413	RHEA:26531	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23129|RHEA:26531	Shared CHEBI:58574 supplies material continuity in the source-defined cycle; the graph does not assert that this is the only metabolic fate of the intermediate.	"[{""reference_id"": ""RHEA:23129"", ""source_assertion"": ""The directed reaction produces CHEBI:58574 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23129/rh:products; http://rdf.rhea-db.org/23128_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_23128_compound_6032/rh:compound -> http://rdf.rhea-db.org/Compound_6032/rh:chebi""}, {""reference_id"": ""RHEA:26531"", ""source_assertion"": ""The directed reaction consumes CHEBI:58574 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26531/rh:substrates; http://rdf.rhea-db.org/26530_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26530_compound_6032/rh:compound -> http://rdf.rhea-db.org/Compound_6032/rh:chebi""}]"	"[{""id"": ""RHEA:23129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23129 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26531"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26531 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-159_516b0bc8ab5d	RHEA:26531	RO:0002413	RHEA:26560	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26531|RHEA:26560	Shared CHEBI:57332 supplies material continuity in the source-defined cycle; the graph does not assert that this is the only metabolic fate of the intermediate.	"[{""reference_id"": ""RHEA:26531"", ""source_assertion"": ""The directed reaction produces CHEBI:57332 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26531/rh:products; http://rdf.rhea-db.org/26530_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26530_compound_2633/rh:compound -> http://rdf.rhea-db.org/Compound_2633/rh:chebi""}, {""reference_id"": ""RHEA:26560"", ""source_assertion"": ""The directed reaction consumes CHEBI:57332 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26560/rh:substrates; http://rdf.rhea-db.org/26558_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_26558_compound_2633/rh:compound -> http://rdf.rhea-db.org/Compound_2633/rh:chebi""}]"	"[{""id"": ""RHEA:26531"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26531 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26560"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26560 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-160_52b986ee8546	RHEA:26560	RO:0002413	RHEA:30800	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26560|RHEA:30800	Shared CHEBI:57316 supplies material continuity in the source-defined cycle; the graph does not assert that this is the only metabolic fate of the intermediate.	"[{""reference_id"": ""RHEA:26560"", ""source_assertion"": ""The directed reaction produces CHEBI:57316 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26560/rh:products; http://rdf.rhea-db.org/26558_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_26558_compound_2192/rh:compound -> http://rdf.rhea-db.org/Compound_2192/rh:chebi""}, {""reference_id"": ""RHEA:30800"", ""source_assertion"": ""The directed reaction consumes CHEBI:57316 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30800/rh:substrates; http://rdf.rhea-db.org/30799_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_30799_compound_2192/rh:compound -> http://rdf.rhea-db.org/Compound_2192/rh:chebi""}]"	"[{""id"": ""RHEA:26560"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 26560 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:30800"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 30800 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-161_29a8ae78bad3	RHEA:30800	RO:0002413	RHEA:21038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21038|RHEA:30800	Shared CHEBI:57286 supplies material continuity in the source-defined cycle; the graph does not assert that this is the only metabolic fate of the intermediate.	"[{""reference_id"": ""RHEA:30800"", ""source_assertion"": ""The directed reaction produces CHEBI:57286 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30800/rh:products; http://rdf.rhea-db.org/30799_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_30799_compound_4872/rh:compound -> http://rdf.rhea-db.org/Compound_4872/rh:chebi""}, {""reference_id"": ""RHEA:21038"", ""source_assertion"": ""The directed reaction consumes CHEBI:57286 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/21038/rh:substrates; http://rdf.rhea-db.org/21036_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_21036_compound_4872/rh:compound -> http://rdf.rhea-db.org/Compound_4872/rh:chebi""}]"	"[{""id"": ""RHEA:21038"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 21038 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:30800"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 30800 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-162_e587836b1146	RHEA:21038	RO:0002413	RHEA:11309	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11309|RHEA:21038	Shared CHEBI:57288 supplies material continuity in the source-defined cycle; the graph does not assert that this is the only metabolic fate of the intermediate.	"[{""reference_id"": ""RHEA:21038"", ""source_assertion"": ""The directed reaction produces CHEBI:57288 with coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/21038/rh:products; http://rdf.rhea-db.org/21036_L/rh:contains2 -> http://rdf.rhea-db.org/Participant_21036_compound_4271/rh:compound -> http://rdf.rhea-db.org/Compound_4271/rh:chebi""}, {""reference_id"": ""RHEA:11309"", ""source_assertion"": ""The directed reaction consumes CHEBI:57288 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/11309/rh:substrates; http://rdf.rhea-db.org/11308_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_11308_compound_4271/rh:compound -> http://rdf.rhea-db.org/Compound_4271/rh:chebi""}]"	"[{""id"": ""RHEA:11309"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 11309 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:21038"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 21038 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-163_8f6b994647f9	RHEA:10750	RO:0002413	RHEA:11309	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750|RHEA:11309	Shared CHEBI:17544 supplies material continuity in the source-defined cycle; the graph does not assert that this is the only metabolic fate of the intermediate.	"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""The directed reaction produces CHEBI:17544 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10750/rh:products; http://rdf.rhea-db.org/10748_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_10748_compound_1123/rh:compound -> http://rdf.rhea-db.org/Compound_1123/rh:chebi""}, {""reference_id"": ""RHEA:11309"", ""source_assertion"": ""The directed reaction consumes CHEBI:17544 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/11309/rh:substrates; http://rdf.rhea-db.org/11308_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_11308_compound_1123/rh:compound -> http://rdf.rhea-db.org/Compound_1123/rh:chebi""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 10750 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:11309"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 11309 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5789_hphb-edge-164_1c10802c8d75	RHEA:10750	RO:0002413	RHEA:23721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10750|RHEA:23721	Shared CHEBI:17544 supplies material continuity in the source-defined cycle; the graph does not assert that this is the only metabolic fate of the intermediate.	"[{""reference_id"": ""RHEA:10750"", ""source_assertion"": ""The directed reaction produces CHEBI:17544 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10750/rh:products; http://rdf.rhea-db.org/10748_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_10748_compound_1123/rh:compound -> http://rdf.rhea-db.org/Compound_1123/rh:chebi""}, {""reference_id"": ""RHEA:23721"", ""source_assertion"": ""The directed reaction consumes CHEBI:17544 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/23721/rh:substrates; http://rdf.rhea-db.org/23720_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_23720_compound_1123/rh:compound -> http://rdf.rhea-db.org/Compound_1123/rh:chebi""}]"	"[{""id"": ""RHEA:10750"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 10750 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:23721"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 23721 directed reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-001_6ffb08a6cdc1	CHEBI:137981	pathwaymech:consumes	RHEA:19318	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19318		"[{""reference_id"": ""RHEA:19318"", ""source_assertion"": ""Rhea lists CHEBI:137981 on the substrates side of RHEA:19318 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19318']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19318"", ""source_version"": ""139"", ""title"": ""Rhea N5-CAIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19318""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-002_5375343c7538	CHEBI:17544	pathwaymech:consumes	RHEA:19318	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19318		"[{""reference_id"": ""RHEA:19318"", ""source_assertion"": ""Rhea lists CHEBI:17544 on the substrates side of RHEA:19318 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19318']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19318"", ""source_version"": ""139"", ""title"": ""Rhea N5-CAIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19318""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-003_c557a06677a2	CHEBI:30616	pathwaymech:consumes	RHEA:19318	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19318		"[{""reference_id"": ""RHEA:19318"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:19318 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19318']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19318"", ""source_version"": ""139"", ""title"": ""Rhea N5-CAIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19318""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-004_8c4a20b23d53	RHEA:19318	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19318		"[{""reference_id"": ""RHEA:19318"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:19318 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19318']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19318"", ""source_version"": ""139"", ""title"": ""Rhea N5-CAIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19318""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-005_6a889b5a27bd	RHEA:19318	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19318		"[{""reference_id"": ""RHEA:19318"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:19318 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19318']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19318"", ""source_version"": ""139"", ""title"": ""Rhea N5-CAIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19318""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-006_cd2f1df98326	RHEA:19318	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19318		"[{""reference_id"": ""RHEA:19318"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:19318 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19318']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19318"", ""source_version"": ""139"", ""title"": ""Rhea N5-CAIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19318""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-007_23fe0059f473	RHEA:19318	pathwaymech:produces	CHEBI:58730	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19318		"[{""reference_id"": ""RHEA:19318"", ""source_assertion"": ""Rhea lists CHEBI:58730 on the products side of RHEA:19318 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19318']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19318"", ""source_version"": ""139"", ""title"": ""Rhea N5-CAIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19318""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-008_5852f0a886e8	CHEBI:15378	pathwaymech:consumes	RHEA:13194	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13194		"[{""reference_id"": ""RHEA:13194"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:13194 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13194']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13194"", ""source_version"": ""139"", ""title"": ""Rhea CAIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/13194""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-009_5dbf3aef8ac3	CHEBI:58730	pathwaymech:consumes	RHEA:13194	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13194		"[{""reference_id"": ""RHEA:13194"", ""source_assertion"": ""Rhea lists CHEBI:58730 on the substrates side of RHEA:13194 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13194']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13194"", ""source_version"": ""139"", ""title"": ""Rhea CAIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/13194""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-010_098e705b33d7	RHEA:13194	pathwaymech:produces	CHEBI:77657	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13194		"[{""reference_id"": ""RHEA:13194"", ""source_assertion"": ""Rhea lists CHEBI:77657 on the products side of RHEA:13194 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13194']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13194"", ""source_version"": ""139"", ""title"": ""Rhea CAIR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/13194""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-011_a6ae6291ba33	CHEBI:29991	pathwaymech:consumes	RHEA:22629	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22629		"[{""reference_id"": ""RHEA:22629"", ""source_assertion"": ""Rhea lists CHEBI:29991 on the substrates side of RHEA:22629 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22629']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22629"", ""source_version"": ""139"", ""title"": ""Rhea SAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22629""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-012_16597b496f67	CHEBI:30616	pathwaymech:consumes	RHEA:22629	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22629		"[{""reference_id"": ""RHEA:22629"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:22629 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22629']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22629"", ""source_version"": ""139"", ""title"": ""Rhea SAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22629""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-013_763b3877896e	CHEBI:77657	pathwaymech:consumes	RHEA:22629	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22629		"[{""reference_id"": ""RHEA:22629"", ""source_assertion"": ""Rhea lists CHEBI:77657 on the substrates side of RHEA:22629 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22629']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22629"", ""source_version"": ""139"", ""title"": ""Rhea SAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22629""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-014_88c15b4226f3	RHEA:22629	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22629		"[{""reference_id"": ""RHEA:22629"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:22629 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22629']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22629"", ""source_version"": ""139"", ""title"": ""Rhea SAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22629""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-015_99e0d8cca6a3	RHEA:22629	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22629		"[{""reference_id"": ""RHEA:22629"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:22629 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22629']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22629"", ""source_version"": ""139"", ""title"": ""Rhea SAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22629""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-016_3e3ad2822267	RHEA:22629	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22629		"[{""reference_id"": ""RHEA:22629"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:22629 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22629']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22629"", ""source_version"": ""139"", ""title"": ""Rhea SAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22629""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-017_7efe9c7c620f	RHEA:22629	pathwaymech:produces	CHEBI:58443	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22629		"[{""reference_id"": ""RHEA:22629"", ""source_assertion"": ""Rhea lists CHEBI:58443 on the products side of RHEA:22629 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22629']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22629"", ""source_version"": ""139"", ""title"": ""Rhea SAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22629""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-018_c6f1b4ae7815	CHEBI:58443	pathwaymech:consumes	RHEA:23921	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23921		"[{""reference_id"": ""RHEA:23921"", ""source_assertion"": ""Rhea lists CHEBI:58443 on the substrates side of RHEA:23921 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23921']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23921"", ""source_version"": ""139"", ""title"": ""Rhea AICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23921""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-019_ca324eb5dbca	RHEA:23921	pathwaymech:produces	CHEBI:29806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23921		"[{""reference_id"": ""RHEA:23921"", ""source_assertion"": ""Rhea lists CHEBI:29806 on the products side of RHEA:23921 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23921']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23921"", ""source_version"": ""139"", ""title"": ""Rhea AICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23921""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-020_6fcf93c036ee	RHEA:23921	pathwaymech:produces	CHEBI:58475	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23921		"[{""reference_id"": ""RHEA:23921"", ""source_assertion"": ""Rhea lists CHEBI:58475 on the products side of RHEA:23921 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23921']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23921"", ""source_version"": ""139"", ""title"": ""Rhea AICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23921""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-021_abd8241a22a6	CHEBI:195366	pathwaymech:consumes	RHEA:22193	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22193		"[{""reference_id"": ""RHEA:22193"", ""source_assertion"": ""Rhea lists CHEBI:195366 on the substrates side of RHEA:22193 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22193']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22193"", ""source_version"": ""139"", ""title"": ""Rhea FAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22193""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-022_1f7c41b909e6	CHEBI:58475	pathwaymech:consumes	RHEA:22193	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22193		"[{""reference_id"": ""RHEA:22193"", ""source_assertion"": ""Rhea lists CHEBI:58475 on the substrates side of RHEA:22193 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22193']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22193"", ""source_version"": ""139"", ""title"": ""Rhea FAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22193""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-023_8363d87b90af	RHEA:22193	pathwaymech:produces	CHEBI:57453	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22193		"[{""reference_id"": ""RHEA:22193"", ""source_assertion"": ""Rhea lists CHEBI:57453 on the products side of RHEA:22193 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22193']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22193"", ""source_version"": ""139"", ""title"": ""Rhea FAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22193""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-024_b5e359e14047	RHEA:22193	pathwaymech:produces	CHEBI:58467	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22193		"[{""reference_id"": ""RHEA:22193"", ""source_assertion"": ""Rhea lists CHEBI:58467 on the products side of RHEA:22193 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22193']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22193"", ""source_version"": ""139"", ""title"": ""Rhea FAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22193""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-025_af19804adb51	CHEBI:58467	pathwaymech:consumes	RHEA:18447	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18447		"[{""reference_id"": ""RHEA:18447"", ""source_assertion"": ""Rhea lists CHEBI:58467 on the substrates side of RHEA:18447 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18447']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18447"", ""source_version"": ""139"", ""title"": ""Rhea IMP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18447""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-026_bf5bcdbe0c75	RHEA:18447	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18447		"[{""reference_id"": ""RHEA:18447"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:18447 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18447']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18447"", ""source_version"": ""139"", ""title"": ""Rhea IMP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18447""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-027_c81dc003ed20	RHEA:18447	pathwaymech:produces	CHEBI:58053	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18447		"[{""reference_id"": ""RHEA:18447"", ""source_assertion"": ""Rhea lists CHEBI:58053 on the products side of RHEA:18447 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18447']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18447"", ""source_version"": ""139"", ""title"": ""Rhea IMP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18447""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-028_739e88127438	EC:6.3.4.18	pathwaymech:catalyzes	RHEA:19318	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19317		"[{""reference_id"": ""RHEA:19317"", ""source_assertion"": ""Rhea associates EC:6.3.4.18 with the reaction family containing RHEA:19318."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:19317"", ""source_version"": ""139"", ""title"": ""Rhea 5-(carboxyamino)imidazole ribonucleotide synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/19317""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-029_28d70d7cc66c	EC:5.4.99.18	pathwaymech:catalyzes	RHEA:13194	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13193		"[{""reference_id"": ""RHEA:13193"", ""source_assertion"": ""Rhea associates EC:5.4.99.18 with the reaction family containing RHEA:13194."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:13193"", ""source_version"": ""139"", ""title"": ""Rhea 5-(carboxyamino)imidazole ribonucleotide mutase reaction"", ""url"": ""https://www.rhea-db.org/rhea/13193""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-030_aaeec3a81693	EC:6.3.2.6	pathwaymech:catalyzes	RHEA:22629	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22628		"[{""reference_id"": ""RHEA:22628"", ""source_assertion"": ""Rhea associates EC:6.3.2.6 with the reaction family containing RHEA:22629."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:22628"", ""source_version"": ""139"", ""title"": ""Rhea SAICAR synthetase reaction"", ""url"": ""https://www.rhea-db.org/rhea/22628""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-031_c8044f3fa55c	EC:4.3.2.2	pathwaymech:catalyzes	RHEA:23921	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23920		"[{""reference_id"": ""RHEA:23920"", ""source_assertion"": ""Rhea associates EC:4.3.2.2 with the reaction family containing RHEA:23921."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:23920"", ""source_version"": ""139"", ""title"": ""Rhea adenylosuccinate lyase AICAR-forming reaction"", ""url"": ""https://www.rhea-db.org/rhea/23920""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-032_860865c9600d	EC:2.1.2.3	pathwaymech:catalyzes	RHEA:22193	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22192		"[{""reference_id"": ""RHEA:22192"", ""source_assertion"": ""Rhea associates EC:2.1.2.3 with the reaction family containing RHEA:22193."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:22192"", ""source_version"": ""139"", ""title"": ""Rhea AICAR transformylase reaction"", ""url"": ""https://www.rhea-db.org/rhea/22192""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-033_c791572564c5	EC:3.5.4.10	pathwaymech:catalyzes	RHEA:18447	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18445		"[{""reference_id"": ""RHEA:18445"", ""source_assertion"": ""Rhea associates EC:3.5.4.10 with the reaction family containing RHEA:18447."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:18445"", ""source_version"": ""139"", ""title"": ""Rhea IMP cyclohydrolase reaction"", ""url"": ""https://www.rhea-db.org/rhea/18445""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-034_c962fcf92a13	RHEA:13194	pathwaymech:precedes	RHEA:22629	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6123		"[{""reference_id"": ""MetaCyc:PWY-6123"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:13194 before RHEA:22629 in this pathway. Shared intermediate: CHEBI:77657."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-6123"", ""source_sha256"": ""291fc3a71844194044d8a274a3d9c1a8b7ecd25868df8fa94c61a469fc2cdab4"", ""source_version"": ""22.5"", ""title"": ""MetaCyc inosine-5'-phosphate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-6123&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-035_200f69f01a6a	RHEA:19318	pathwaymech:precedes	RHEA:13194	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6123		"[{""reference_id"": ""MetaCyc:PWY-6123"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:19318 before RHEA:13194 in this pathway. Shared intermediate: CHEBI:58730."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-6123"", ""source_sha256"": ""291fc3a71844194044d8a274a3d9c1a8b7ecd25868df8fa94c61a469fc2cdab4"", ""source_version"": ""22.5"", ""title"": ""MetaCyc inosine-5'-phosphate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-6123&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-036_7fadec20a458	RHEA:22193	pathwaymech:precedes	RHEA:18447	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6123		"[{""reference_id"": ""MetaCyc:PWY-6123"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:22193 before RHEA:18447 in this pathway. Shared intermediate: CHEBI:58467."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-6123"", ""source_sha256"": ""291fc3a71844194044d8a274a3d9c1a8b7ecd25868df8fa94c61a469fc2cdab4"", ""source_version"": ""22.5"", ""title"": ""MetaCyc inosine-5'-phosphate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-6123&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-037_3ac451c67464	RHEA:22629	pathwaymech:precedes	RHEA:23921	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6123		"[{""reference_id"": ""MetaCyc:PWY-6123"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:22629 before RHEA:23921 in this pathway. Shared intermediate: CHEBI:58443."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-6123"", ""source_sha256"": ""291fc3a71844194044d8a274a3d9c1a8b7ecd25868df8fa94c61a469fc2cdab4"", ""source_version"": ""22.5"", ""title"": ""MetaCyc inosine-5'-phosphate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-6123&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-038_dcc514ca3746	RHEA:23921	pathwaymech:precedes	RHEA:22193	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6123		"[{""reference_id"": ""MetaCyc:PWY-6123"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:23921 before RHEA:22193 in this pathway. Shared intermediate: CHEBI:58475."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-6123"", ""source_sha256"": ""291fc3a71844194044d8a274a3d9c1a8b7ecd25868df8fa94c61a469fc2cdab4"", ""source_version"": ""22.5"", ""title"": ""MetaCyc inosine-5'-phosphate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-6123&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-039_41773a9c8286	UniProtKB:P09029	pathwaymech:enables	RHEA:19318	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09029		"[{""reference_id"": ""UniProtKB:P09029"", ""source_assertion"": ""UniProt annotates UniProtKB:P09029 with catalytic activity for the reaction family of RHEA:19318. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P09029"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P09029 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P09029.json""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-040_0aab951b3115	UniProtKB:P0A7D7	pathwaymech:enables	RHEA:22629	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A7D7		"[{""reference_id"": ""UniProtKB:P0A7D7"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A7D7 with catalytic activity for the reaction family of RHEA:22629. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A7D7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A7D7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A7D7.json""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-041_0d61b2387f26	UniProtKB:P0AB89	pathwaymech:enables	RHEA:23921	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AB89		"[{""reference_id"": ""UniProtKB:P0AB89"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AB89 with catalytic activity for the reaction family of RHEA:23921. Annotation evidence: ECO:0000305; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AB89"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AB89 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AB89.json""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-042_48fbe2a6e2e3	UniProtKB:P0AG18	pathwaymech:enables	RHEA:13194	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AG18		"[{""reference_id"": ""UniProtKB:P0AG18"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AG18 with catalytic activity for the reaction family of RHEA:13194. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AG18"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AG18 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AG18.json""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-043_89a0111fb4e9	UniProtKB:P15639	pathwaymech:enables	RHEA:22193	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15639		"[{""reference_id"": ""UniProtKB:P15639"", ""source_assertion"": ""UniProt annotates UniProtKB:P15639 with catalytic activity for the reaction family of RHEA:22193. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P15639"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P15639 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P15639.json""}]"	""
pathwaymech:MetaCyc_PWY-6123_edge-044_35d5c6945c10	UniProtKB:P15639	pathwaymech:enables	RHEA:18447	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15639		"[{""reference_id"": ""UniProtKB:P15639"", ""source_assertion"": ""UniProt annotates UniProtKB:P15639 with catalytic activity for the reaction family of RHEA:18447. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P15639"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P15639 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P15639.json""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-001_8543257660ec	CHEBI:29991	pathwaymech:consumes	RHEA:22629	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22629		"[{""reference_id"": ""RHEA:22629"", ""source_assertion"": ""Rhea lists CHEBI:29991 on the substrates side of RHEA:22629 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22629']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22629"", ""source_version"": ""139"", ""title"": ""Rhea SAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22629""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-002_eca0d10745bb	CHEBI:30616	pathwaymech:consumes	RHEA:22629	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22629		"[{""reference_id"": ""RHEA:22629"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:22629 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22629']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22629"", ""source_version"": ""139"", ""title"": ""Rhea SAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22629""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-003_e3357ace4bc0	CHEBI:77657	pathwaymech:consumes	RHEA:22629	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22629		"[{""reference_id"": ""RHEA:22629"", ""source_assertion"": ""Rhea lists CHEBI:77657 on the substrates side of RHEA:22629 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22629']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22629"", ""source_version"": ""139"", ""title"": ""Rhea SAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22629""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-004_105247c92073	RHEA:22629	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22629		"[{""reference_id"": ""RHEA:22629"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:22629 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22629']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22629"", ""source_version"": ""139"", ""title"": ""Rhea SAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22629""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-005_e6c440c7aa0f	RHEA:22629	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22629		"[{""reference_id"": ""RHEA:22629"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:22629 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22629']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22629"", ""source_version"": ""139"", ""title"": ""Rhea SAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22629""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-006_77b5c071f130	RHEA:22629	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22629		"[{""reference_id"": ""RHEA:22629"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:22629 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22629']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22629"", ""source_version"": ""139"", ""title"": ""Rhea SAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22629""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-007_2b6e43bc58d8	RHEA:22629	pathwaymech:produces	CHEBI:58443	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22629		"[{""reference_id"": ""RHEA:22629"", ""source_assertion"": ""Rhea lists CHEBI:58443 on the products side of RHEA:22629 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22629']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22629"", ""source_version"": ""139"", ""title"": ""Rhea SAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22629""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-008_46b75e875e19	CHEBI:58443	pathwaymech:consumes	RHEA:23921	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23921		"[{""reference_id"": ""RHEA:23921"", ""source_assertion"": ""Rhea lists CHEBI:58443 on the substrates side of RHEA:23921 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23921']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23921"", ""source_version"": ""139"", ""title"": ""Rhea AICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23921""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-009_44f6d5a269ea	RHEA:23921	pathwaymech:produces	CHEBI:29806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23921		"[{""reference_id"": ""RHEA:23921"", ""source_assertion"": ""Rhea lists CHEBI:29806 on the products side of RHEA:23921 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23921']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23921"", ""source_version"": ""139"", ""title"": ""Rhea AICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23921""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-010_49734fd3acca	RHEA:23921	pathwaymech:produces	CHEBI:58475	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23921		"[{""reference_id"": ""RHEA:23921"", ""source_assertion"": ""Rhea lists CHEBI:58475 on the products side of RHEA:23921 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23921']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23921"", ""source_version"": ""139"", ""title"": ""Rhea AICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23921""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-011_4f53280dd216	CHEBI:195366	pathwaymech:consumes	RHEA:22193	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22193		"[{""reference_id"": ""RHEA:22193"", ""source_assertion"": ""Rhea lists CHEBI:195366 on the substrates side of RHEA:22193 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22193']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22193"", ""source_version"": ""139"", ""title"": ""Rhea FAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22193""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-012_77fbda2eb145	CHEBI:58475	pathwaymech:consumes	RHEA:22193	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22193		"[{""reference_id"": ""RHEA:22193"", ""source_assertion"": ""Rhea lists CHEBI:58475 on the substrates side of RHEA:22193 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22193']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22193"", ""source_version"": ""139"", ""title"": ""Rhea FAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22193""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-013_a8b4e5133ccf	RHEA:22193	pathwaymech:produces	CHEBI:57453	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22193		"[{""reference_id"": ""RHEA:22193"", ""source_assertion"": ""Rhea lists CHEBI:57453 on the products side of RHEA:22193 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22193']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22193"", ""source_version"": ""139"", ""title"": ""Rhea FAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22193""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-014_e4fbccdd994f	RHEA:22193	pathwaymech:produces	CHEBI:58467	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22193		"[{""reference_id"": ""RHEA:22193"", ""source_assertion"": ""Rhea lists CHEBI:58467 on the products side of RHEA:22193 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22193']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22193"", ""source_version"": ""139"", ""title"": ""Rhea FAICAR-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22193""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-015_d30f59e5e451	CHEBI:58467	pathwaymech:consumes	RHEA:18447	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18447		"[{""reference_id"": ""RHEA:18447"", ""source_assertion"": ""Rhea lists CHEBI:58467 on the substrates side of RHEA:18447 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18447']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18447"", ""source_version"": ""139"", ""title"": ""Rhea IMP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18447""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-016_f2953625c424	RHEA:18447	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18447		"[{""reference_id"": ""RHEA:18447"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:18447 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18447']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18447"", ""source_version"": ""139"", ""title"": ""Rhea IMP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18447""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-017_5a04d816ea32	RHEA:18447	pathwaymech:produces	CHEBI:58053	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18447		"[{""reference_id"": ""RHEA:18447"", ""source_assertion"": ""Rhea lists CHEBI:58053 on the products side of RHEA:18447 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18447']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18447"", ""source_version"": ""139"", ""title"": ""Rhea IMP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18447""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-018_e5bc1b9e4ff5	CHEBI:137981	pathwaymech:consumes	RHEA:10794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10794		"[{""reference_id"": ""RHEA:10794"", ""source_assertion"": ""Rhea lists CHEBI:137981 on the substrates side of RHEA:10794 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10794']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10794"", ""source_version"": ""139"", ""title"": ""RHEA:10794 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10794""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-019_65fb10520b89	CHEBI:16526	pathwaymech:consumes	RHEA:10794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10794		"[{""reference_id"": ""RHEA:10794"", ""source_assertion"": ""Rhea lists CHEBI:16526 on the substrates side of RHEA:10794 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10794']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10794"", ""source_version"": ""139"", ""title"": ""RHEA:10794 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10794""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-020_5098cb2f5797	RHEA:10794	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10794		"[{""reference_id"": ""RHEA:10794"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:10794 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10794']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10794"", ""source_version"": ""139"", ""title"": ""RHEA:10794 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10794""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-021_e6348d67e5d7	RHEA:10794	pathwaymech:produces	CHEBI:77657	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10794		"[{""reference_id"": ""RHEA:10794"", ""source_assertion"": ""Rhea lists CHEBI:77657 on the products side of RHEA:10794 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10794']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10794"", ""source_version"": ""139"", ""title"": ""RHEA:10794 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10794""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-022_ff65966eb808	EC:4.1.1.21	pathwaymech:catalyzes	RHEA:10794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21548610|RHEA:10792		"[{""reference_id"": ""RHEA:10792"", ""source_assertion"": ""Rhea associates EC:4.1.1.21 with the reaction family containing RHEA:10794."", ""source_locator"": ""rh:ec""}, {""reference_id"": ""PMID:21548610"", ""source_assertion"": ""The study demonstrates AIR carboxylase activity of class II PurE in Treponema denticola, supporting the direct AIR-to-CAIR route in this bacterial taxon."", ""source_locator"": ""PubMed Abstract; purified TdPurE catalytic activity""}]"	"[{""id"": ""PMID:21548610"", ""title"": ""PMID:21548610 authority record"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/21548610/""}, {""id"": ""RHEA:10792"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosylaminoimidazole carboxylase reaction"", ""url"": ""https://www.rhea-db.org/rhea/10792""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-023_0ac8a4e93b44	EC:6.3.2.6	pathwaymech:catalyzes	RHEA:22629	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22628		"[{""reference_id"": ""RHEA:22628"", ""source_assertion"": ""Rhea associates EC:6.3.2.6 with the reaction family containing RHEA:22629."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:22628"", ""source_version"": ""139"", ""title"": ""Rhea SAICAR synthetase reaction"", ""url"": ""https://www.rhea-db.org/rhea/22628""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-024_c2e83165a9b8	EC:4.3.2.2	pathwaymech:catalyzes	RHEA:23921	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23920		"[{""reference_id"": ""RHEA:23920"", ""source_assertion"": ""Rhea associates EC:4.3.2.2 with the reaction family containing RHEA:23921."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:23920"", ""source_version"": ""139"", ""title"": ""Rhea adenylosuccinate lyase AICAR-forming reaction"", ""url"": ""https://www.rhea-db.org/rhea/23920""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-025_b650739a9729	EC:2.1.2.3	pathwaymech:catalyzes	RHEA:22193	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22192		"[{""reference_id"": ""RHEA:22192"", ""source_assertion"": ""Rhea associates EC:2.1.2.3 with the reaction family containing RHEA:22193."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:22192"", ""source_version"": ""139"", ""title"": ""Rhea AICAR transformylase reaction"", ""url"": ""https://www.rhea-db.org/rhea/22192""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-026_b13d42038001	EC:3.5.4.10	pathwaymech:catalyzes	RHEA:18447	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18445		"[{""reference_id"": ""RHEA:18445"", ""source_assertion"": ""Rhea associates EC:3.5.4.10 with the reaction family containing RHEA:18447."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:18445"", ""source_version"": ""139"", ""title"": ""Rhea IMP cyclohydrolase reaction"", ""url"": ""https://www.rhea-db.org/rhea/18445""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-027_b18792ab038b	RHEA:10794	pathwaymech:precedes	RHEA:22629	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6124		"[{""reference_id"": ""MetaCyc:PWY-6124"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:10794 before RHEA:22629 in this pathway. Shared intermediate: CHEBI:77657."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-6124"", ""source_sha256"": ""969176738687da57e6302f686b8e791bc28f3d82e47e77c8815011fcd1b2c322"", ""source_version"": ""22.5"", ""title"": ""MetaCyc inosine-5'-phosphate biosynthesis II pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-6124&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-028_8da0c6d22d9e	RHEA:22193	pathwaymech:precedes	RHEA:18447	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6124		"[{""reference_id"": ""MetaCyc:PWY-6124"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:22193 before RHEA:18447 in this pathway. Shared intermediate: CHEBI:58467."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-6124"", ""source_sha256"": ""969176738687da57e6302f686b8e791bc28f3d82e47e77c8815011fcd1b2c322"", ""source_version"": ""22.5"", ""title"": ""MetaCyc inosine-5'-phosphate biosynthesis II pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-6124&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-029_8c2e0ccb5774	RHEA:22629	pathwaymech:precedes	RHEA:23921	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6124		"[{""reference_id"": ""MetaCyc:PWY-6124"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:22629 before RHEA:23921 in this pathway. Shared intermediate: CHEBI:58443."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-6124"", ""source_sha256"": ""969176738687da57e6302f686b8e791bc28f3d82e47e77c8815011fcd1b2c322"", ""source_version"": ""22.5"", ""title"": ""MetaCyc inosine-5'-phosphate biosynthesis II pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-6124&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-030_6edd14e43cb3	RHEA:23921	pathwaymech:precedes	RHEA:22193	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6124		"[{""reference_id"": ""MetaCyc:PWY-6124"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:23921 before RHEA:22193 in this pathway. Shared intermediate: CHEBI:58475."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-6124"", ""source_sha256"": ""969176738687da57e6302f686b8e791bc28f3d82e47e77c8815011fcd1b2c322"", ""source_version"": ""22.5"", ""title"": ""MetaCyc inosine-5'-phosphate biosynthesis II pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-6124&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6124_edge-031_5f5282de75cf	UniProtKB:Q73PV9	pathwaymech:enables	RHEA:10794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q73PV9		"[{""reference_id"": ""UniProtKB:Q73PV9"", ""source_assertion"": ""UniProt annotates UniProtKB:Q73PV9 with catalytic activity for the reaction family of RHEA:10794. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:243275."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:Q73PV9"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:Q73PV9 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q73PV9.json""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-001_04013027ad06	gomodel:RXN-7162	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7162 RO:0002234 gomodel:CHEBI_15378_RXN-7162."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/0; endpoint types: /individuals/56/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-002_6f87a972f095	gomodel:RXN-4941	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-4941 RO:0002234 gomodel:CHEBI_456216_RXN-4941."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/1; endpoint types: /individuals/55/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-003_b896cfa2e548	gomodel:RXN-7163	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7163 RO:0002234 gomodel:CHEBI_456216_RXN-7163."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/2; endpoint types: /individuals/57/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-004_7d6ec156a32d	gomodel:2.7.1.127-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.127-RXN RO:0002234 gomodel:CHEBI_456216_2.7.1.127-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/3; endpoint types: /individuals/166/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-005_f19147fe907b	gomodel:RXN-7162	BFO:0000050	GO:0032958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7162 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/4; endpoint types: /individuals/56/type; /individuals/170/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-006_2282589a452b	SGD:S000002424	pathwaymech:enables	gomodel:2.7.1.152-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.152-RXN RO:0002333 gomodel:MONOMER3O-205_2.7.1.152-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/5; endpoint types: /individuals/168/type; /individuals/47/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-007_88337832f8a0	gomodel:RXN3O-258	BFO:0000050	GO:0032958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-258 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/6; endpoint types: /individuals/60/type; /individuals/170/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-008_d76faa221fb2	gomodel:2.7.1.127-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.127-RXN RO:0002234 gomodel:CHEBI_15378_2.7.1.127-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/7; endpoint types: /individuals/166/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-009_ca066e5a7c78	gomodel:2.7.1.127-RXN	RO:0002233	CHEBI:203600	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.127-RXN RO:0002233 gomodel:CHEBI_203600_3.1.4.11-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/8; endpoint types: /individuals/166/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-010_eb46ac3a2acf	gomodel:RXN3O-9819	RO:0002233	CHEBI:74946	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12494	Corrected the Kcs1-specific IP7/IP8 isomers.	"[{""reference_id"": ""UniProtKB:Q12494"", ""source_assertion"": ""Kcs1 RHEA:37467 adds the 5-position diphosphate to 1-IP7 (CHEBI:74946), producing 1,5-IP8 (CHEBI:77983)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3127/comments/2""}]"	"[{""id"": ""UniProtKB:Q12494"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12494 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-011_caf53a247336	gomodel:3.1.4.11-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:3.1.4.11-RXN BFO:0000066 gomodel:reaction_3.1.4.11-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/10; endpoint types: /individuals/169/type; /individuals/156/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-012_156f53744673	gomodel:RXN-7162	RO:0002233	CHEBI:57627	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7162 RO:0002233 gomodel:CHEBI_57627_2.7.1.151-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/11; endpoint types: /individuals/56/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-013_9d3b70951d6e	gomodel:2.7.1.151-RXN	BFO:0000050	GO:0032958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.151-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/12; endpoint types: /individuals/167/type; /individuals/170/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-014_348347edc2c3	gomodel:RXN3O-786	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-786 BFO:0000066 gomodel:reaction_RXN3O-786_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/13; endpoint types: /individuals/62/type; /individuals/164/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-015_53fc0f505aaf	gomodel:RXN3O-786	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-786 RO:0002233 gomodel:CHEBI_15377_RXN3O-786."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/14; endpoint types: /individuals/62/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-016_b56f8d20b1a6	gomodel:2.7.1.127-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.127-RXN RO:0002233 gomodel:CHEBI_30616_2.7.1.127-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/15; endpoint types: /individuals/166/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-017_f214d42b45a2	SGD:S000002723	pathwaymech:enables	gomodel:RXN-7163	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7163 RO:0002333 gomodel:YDR315C-MONOMER_RXN-7163_controller."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/16; endpoint types: /individuals/57/type; /individuals/64/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-018_3b8054fafe70	gomodel:2.7.1.151-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.151-RXN RO:0002234 gomodel:CHEBI_15378_2.7.1.151-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/17; endpoint types: /individuals/167/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-019_19f0853d435a	gomodel:RXN-7162	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7162 RO:0002234 gomodel:CHEBI_456216_RXN-7162."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/18; endpoint types: /individuals/56/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-021_93eae88348e1	gomodel:RXN3O-258	RO:0002233	CHEBI:58130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-258 RO:0002233 gomodel:CHEBI_58130_RXN-7163."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/20; endpoint types: /individuals/60/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-022_1d7ced155052	SGD:S000005689	pathwaymech:enables	gomodel:RXN3O-786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-786 RO:0002333 gomodel:YOR163W-MONOMER_RXN3O-786_controller."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/21; endpoint types: /individuals/62/type; /individuals/66/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-023_6591f0d331e2	gomodel:YeastPathways_PWY3O-402/6a4c244800000690	RO:0002234	gomodel:CHEBI_14178_RXN-4941	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:10827188	Preserved the independently existing native generic PP-InsP4 entity; its former CHEBI:14178 type has two diphosphates and is incorrect.	"[{""reference_id"": ""PMID:10827188"", ""source_assertion"": ""Purified yeast inositol hexakisphosphate kinase phosphorylates IP5 to PP-InsP4; this experiment does not establish a unique positional isomer here."", ""source_locator"": ""PubMed abstract, purified kinase substrate/product results""}]"	"[{""id"": ""PMID:10827188"", ""title"": ""The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/10827188/""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-024_13544496e04e	SGD:S000005689	pathwaymech:enables	gomodel:RXN3O-785	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-785 RO:0002333 gomodel:YOR163W-MONOMER_RXN3O-785_controller."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/23; endpoint types: /individuals/61/type; /individuals/65/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-025_f40b495f796a	gomodel:RXN3O-9819	RO:0002234	CHEBI:77983	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12494	Corrected the Kcs1-specific IP7/IP8 isomers.	"[{""reference_id"": ""UniProtKB:Q12494"", ""source_assertion"": ""Kcs1 RHEA:37467 adds the 5-position diphosphate to 1-IP7 (CHEBI:74946), producing 1,5-IP8 (CHEBI:77983)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3127/comments/2""}]"	"[{""id"": ""UniProtKB:Q12494"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12494 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-027_4500fb60561f	SGD:S000002580	pathwaymech:enables	gomodel:2.7.1.127-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.127-RXN RO:0002333 gomodel:MONOMER3O-64_2.7.1.127-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/26; endpoint types: /individuals/166/type; /individuals/50/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-028_1d257d702be8	gomodel:RXN-4941	BFO:0000050	GO:0032958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-4941 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/27; endpoint types: /individuals/55/type; /individuals/170/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-029_55931c183507	SGD:S000002580	pathwaymech:enables	gomodel:RXN-4941	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-4941 RO:0002333 gomodel:MONOMER3O-64_RXN-4941_controller."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/28; endpoint types: /individuals/55/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-030_61b27f49a8d9	gomodel:RXN3O-258	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-258 RO:0002233 gomodel:CHEBI_30616_RXN3O-258."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/29; endpoint types: /individuals/60/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-031_8365479153c4	gomodel:3.1.4.11-RXN	RO:0002234	CHEBI:203600	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:3.1.4.11-RXN RO:0002234 gomodel:CHEBI_203600_3.1.4.11-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/30; endpoint types: /individuals/169/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-032_bb348c12e299	gomodel:RXN3O-258	RO:0002234	CHEBI:74946	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:32303658|UniProtKB:Q06685	Corrected experimentally established Vip1 1-position specificity.	"[{""reference_id"": ""UniProtKB:Q06685"", ""source_assertion"": ""Vip1 adds a diphosphate at inositol position 1: RHEA:37459 produces CHEBI:74946 from inositol hexakisphosphate."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2794/comments/1""}, {""reference_id"": ""PMID:32303658"", ""source_assertion"": ""Crystallography of the Saccharomyces cerevisiae Vip1 kinase product establishes 1-IP7; the old 4/6-IP7 assignment is incorrect."", ""source_locator"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7196807/fullTextXML [sha256:3e4daf11de27f7571fd524187c26585c63365169c80143be547437354180a0c9] //sec[@id='s3']/p""}]"	"[{""id"": ""PMID:32303658"", ""source_sha256"": ""3e4daf11de27f7571fd524187c26585c63365169c80143be547437354180a0c9"", ""title"": ""Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7196807/fullTextXML""}, {""id"": ""UniProtKB:Q06685"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06685 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-033_b6a430164cf0	gomodel:RXN-7184	RO:0002233	CHEBI:57895	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7184 RO:0002233 gomodel:CHEBI_57895_2.7.1.127-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/32; endpoint types: /individuals/58/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-034_60921f27c7e2	gomodel:2.7.1.151-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.151-RXN RO:0002233 gomodel:CHEBI_30616_2.7.1.151-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/33; endpoint types: /individuals/167/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-035_3c1905b96634	gomodel:3.1.4.11-RXN	RO:0002233	CHEBI:18348	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:3.1.4.11-RXN RO:0002233 gomodel:CHEBI_18348_3.1.4.11-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/34; endpoint types: /individuals/169/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-036_aa699aa2ffd4	SGD:S000002580	pathwaymech:enables	gomodel:2.7.1.151-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.151-RXN RO:0002333 gomodel:MONOMER3O-64_2.7.1.151-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/35; endpoint types: /individuals/167/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-037_9a3c8f02db8e	gomodel:RXN3O-9819	BFO:0000050	GO:0032958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9819 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/36; endpoint types: /individuals/63/type; /individuals/170/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-038_67ed309160d2	gomodel:RXN-7184	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7184 RO:0002234 gomodel:CHEBI_456216_RXN-7184."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/37; endpoint types: /individuals/58/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-039_85e6b13eec44	gomodel:RXN3O-143	RO:0002233	CHEBI:58628	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-143 RO:0002233 gomodel:CHEBI_58628_2.7.1.152-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/38; endpoint types: /individuals/59/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-040_c3190139f3a8	gomodel:RXN3O-786	RO:0002233	CHEBI:14178	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q99321	Retained supported generic DDP1 substrates and products without imposing unsupported pyrophosphate positions.	"[{""reference_id"": ""UniProtKB:Q99321"", ""source_assertion"": ""DDP1 hydrolyzes beta-phosphates from diphosphoinositol pentakisphosphate and bis(diphosphoinositol) tetrakisphosphate. This assertion does not identify a positional isomer."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3200/comments/0""}]"	"[{""id"": ""UniProtKB:Q99321"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q99321 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-041_8607e0f98198	gomodel:RXN-4941	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-4941 RO:0002233 gomodel:CHEBI_30616_RXN-4941."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/40; endpoint types: /individuals/55/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-042_cefa772893a5	gomodel:RXN-7163	BFO:0000050	GO:0032958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7163 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/41; endpoint types: /individuals/57/type; /individuals/170/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-043_757cfac8b8a1	gomodel:RXN-7184	RO:0002234	CHEBI:16322	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7184 RO:0002234 gomodel:CHEBI_16322_RXN-7184."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/42; endpoint types: /individuals/58/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-044_63b57e8467eb	gomodel:3.1.4.11-RXN	BFO:0000050	GO:0032958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:3.1.4.11-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/43; endpoint types: /individuals/169/type; /individuals/170/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-045_0ea9ffd880ec	gomodel:RXN-7184	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7184 RO:0002233 gomodel:CHEBI_30616_RXN-7184."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/44; endpoint types: /individuals/58/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-046_334f37868b8b	gomodel:RXN-7163	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7163 RO:0002233 gomodel:CHEBI_30616_RXN-7163."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/45; endpoint types: /individuals/57/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-047_4a120979689e	gomodel:RXN-4941	RO:0002234	gomodel:CHEBI_14178_RXN-4941	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11311242	Preserved the independently existing native generic PP-InsP4 entity; its former CHEBI:14178 type has two diphosphates and is incorrect.	"[{""reference_id"": ""PMID:11311242"", ""source_assertion"": ""Purified Arg82 phosphorylates IP5 to two PP-InsP4 isomers: one diphosphate plus four monophosphates, not bis(diphosphate) InsP4."", ""source_locator"": ""PubMed abstract, purified kinase substrate/product results""}]"	"[{""id"": ""PMID:11311242"", ""title"": ""The transcriptional regulator, Arg82, is a hybrid kinase with both monophosphoinositol and diphosphoinositol polyphosphate synthase activity"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/11311242/""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-048_4b4083b09fec	SGD:S000006189	pathwaymech:enables	gomodel:3.1.4.11-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:3.1.4.11-RXN RO:0002333 gomodel:YPL268W-MONOMER_3.1.4.11-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/47; endpoint types: /individuals/169/type; /individuals/67/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-049_dab66f53f3d9	gomodel:2.7.1.152-RXN	RO:0002233	CHEBI:58130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.152-RXN RO:0002233 gomodel:CHEBI_58130_RXN-7163."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/48; endpoint types: /individuals/168/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-050_dca22d1472b2	gomodel:RXN3O-785	RO:0002233	gomodel:CHEBI_62919_RXN3O-786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q99321	Retained supported generic DDP1 substrates and products without imposing unsupported pyrophosphate positions.	"[{""reference_id"": ""UniProtKB:Q99321"", ""source_assertion"": ""DDP1 hydrolyzes beta-phosphates from diphosphoinositol pentakisphosphate and bis(diphosphoinositol) tetrakisphosphate. This assertion does not identify a positional isomer."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3200/comments/0""}]"	"[{""id"": ""UniProtKB:Q99321"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q99321 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-051_23c349fb6100	gomodel:RXN-7184	BFO:0000050	GO:0032958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7184 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/50; endpoint types: /individuals/58/type; /individuals/170/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-052_c36ec66bf2f9	gomodel:RXN3O-785	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-785 RO:0002233 gomodel:CHEBI_15377_RXN3O-785."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/51; endpoint types: /individuals/61/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-055_ba7a3a8a0238	gomodel:RXN-7163	RO:0002233	CHEBI:16322	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7163 RO:0002233 gomodel:CHEBI_16322_RXN-7184."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/54; endpoint types: /individuals/57/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-056_114688ccf974	gomodel:RXN3O-9819	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9819 RO:0002233 gomodel:CHEBI_30616_RXN3O-9819."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/55; endpoint types: /individuals/63/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-057_1446e344f6df	gomodel:YeastPathways_PWY3O-402/6a4c244800000690	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-402/6a4c244800000690 RO:0002233 gomodel:YeastPathways_PWY3O-402/6a4c244800000691."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/56; endpoint types: /individuals/171/type; /individuals/172/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-058_9fed472815a3	gomodel:RXN3O-258	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-258 RO:0002234 gomodel:CHEBI_456216_RXN3O-258."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/57; endpoint types: /individuals/60/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-059_ced3804e2721	gomodel:2.7.1.152-RXN	BFO:0000050	GO:0032958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.152-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/58; endpoint types: /individuals/168/type; /individuals/170/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-060_32976fdbf363	gomodel:RXN-7163	RO:0002234	CHEBI:58130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7163 RO:0002234 gomodel:CHEBI_58130_RXN-7163."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/59; endpoint types: /individuals/57/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-061_e92badf84aad	gomodel:RXN-7163	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7163 RO:0002234 gomodel:CHEBI_15378_RXN-7163."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/60; endpoint types: /individuals/57/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-062_1f0c2b8e12da	gomodel:RXN3O-786	RO:0002234	gomodel:CHEBI_62919_RXN3O-786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q99321	Retained supported generic DDP1 substrates and products without imposing unsupported pyrophosphate positions.	"[{""reference_id"": ""UniProtKB:Q99321"", ""source_assertion"": ""DDP1 hydrolyzes beta-phosphates from diphosphoinositol pentakisphosphate and bis(diphosphoinositol) tetrakisphosphate. This assertion does not identify a positional isomer."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3200/comments/0""}]"	"[{""id"": ""UniProtKB:Q99321"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q99321 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-063_166ce434cdc3	gomodel:RXN-7184	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7184 RO:0002234 gomodel:CHEBI_15378_RXN-7184."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/62; endpoint types: /individuals/58/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-064_d3dc01434e7d	gomodel:RXN3O-786	BFO:0000050	GO:0032958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-786 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/63; endpoint types: /individuals/62/type; /individuals/170/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-065_403fbb670337	gomodel:2.7.1.127-RXN	BFO:0000050	GO:0032958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.127-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/64; endpoint types: /individuals/166/type; /individuals/170/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-066_0bfeb9c2ab27	gomodel:3.1.4.11-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:3.1.4.11-RXN RO:0002233 gomodel:CHEBI_15377_3.1.4.11-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/65; endpoint types: /individuals/169/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-067_9a5acaf8bd1d	gomodel:RXN3O-9819	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9819 RO:0002234 gomodel:CHEBI_456216_RXN3O-9819."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/66; endpoint types: /individuals/63/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-068_c83c73d90e4a	gomodel:3.1.4.11-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:3.1.4.11-RXN RO:0002234 gomodel:CHEBI_15378_3.1.4.11-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/67; endpoint types: /individuals/169/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-069_09ff698fe520	SGD:S000004402	pathwaymech:enables	gomodel:RXN3O-143	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-143 RO:0002333 gomodel:MONOMER3O-224_RXN3O-143_controller."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/68; endpoint types: /individuals/59/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-070_7d00e8978812	gomodel:2.7.1.151-RXN	RO:0002233	CHEBI:203600	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.151-RXN RO:0002233 gomodel:CHEBI_203600_3.1.4.11-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/69; endpoint types: /individuals/167/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-071_836f094743a2	gomodel:2.7.1.152-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.152-RXN BFO:0000066 gomodel:reaction_2.7.1.152-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/70; endpoint types: /individuals/168/type; /individuals/155/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-072_1b29aae82233	gomodel:2.7.1.152-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.152-RXN RO:0002233 gomodel:CHEBI_30616_2.7.1.152-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/71; endpoint types: /individuals/168/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-073_af9d70182194	SGD:S000004402	pathwaymech:enables	gomodel:RXN3O-258	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-258 RO:0002333 gomodel:MONOMER3O-224_RXN3O-258_controller."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/72; endpoint types: /individuals/60/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-074_4cbcdd1c61fa	gomodel:RXN3O-785	BFO:0000050	GO:0032958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-785 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/73; endpoint types: /individuals/61/type; /individuals/170/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-075_6776ba8c34e8	SGD:S000002580	pathwaymech:enables	gomodel:RXN-7184	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7184 RO:0002333 gomodel:MONOMER3O-64_RXN-7184_controller."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/74; endpoint types: /individuals/58/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-076_d9602691c471	gomodel:2.7.1.152-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.152-RXN RO:0002234 gomodel:CHEBI_456216_2.7.1.152-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/75; endpoint types: /individuals/168/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-077_20cc46380af8	gomodel:RXN3O-785	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-785 BFO:0000066 gomodel:reaction_RXN3O-785_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/76; endpoint types: /individuals/61/type; /individuals/163/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-078_a5f22bdd36ab	gomodel:3.1.4.11-RXN	RO:0002234	CHEBI:17815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:3.1.4.11-RXN RO:0002234 gomodel:CHEBI_17815_3.1.4.11-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/77; endpoint types: /individuals/169/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-080_228ec16109e1	gomodel:RXN3O-785	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-785 RO:0002234 gomodel:CHEBI_43474_RXN3O-785."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/79; endpoint types: /individuals/61/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-081_0c05c65c071c	gomodel:YeastPathways_PWY3O-402/6a4c244800000690	RO:0002233	CHEBI:16322	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-402/6a4c244800000690 RO:0002233 gomodel:CHEBI_16322_RXN-7184."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/80; endpoint types: /individuals/171/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-082_53587d5e9e31	gomodel:YeastPathways_PWY3O-402/6a4c244800000690	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-402/6a4c244800000690 RO:0002234 gomodel:YeastPathways_PWY3O-402/6a4c244800000692."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/81; endpoint types: /individuals/171/type; /individuals/173/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-083_3eef428d3efd	gomodel:YeastPathways_PWY3O-402/6a4c244800000690	BFO:0000050	GO:0032958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-402/6a4c244800000690 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/82; endpoint types: /individuals/171/type; /individuals/170/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-084_1c76f0f8cb20	gomodel:2.7.1.151-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.151-RXN RO:0002234 gomodel:CHEBI_456216_2.7.1.151-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/83; endpoint types: /individuals/167/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-086_a5e6eba4ddc9	SGD:S000002580	pathwaymech:enables	gomodel:RXN-7162	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7162 RO:0002333 gomodel:MONOMER3O-64_RXN-7162_controller."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/85; endpoint types: /individuals/56/type; /individuals/53/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-087_48e61e13053d	gomodel:RXN3O-143	BFO:0000050	GO:0032958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-143 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/86; endpoint types: /individuals/59/type; /individuals/170/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-089_1feece2a7cea	gomodel:RXN3O-143	RO:0002234	CHEBI:77983	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06685	Corrected 1,5-bis(diphosphate) positions; the former 5,6 isomer is unsupported.	"[{""reference_id"": ""UniProtKB:Q06685"", ""source_assertion"": ""Vip1 RHEA:10276 phosphorylates 5-IP7 to 1,5-IP8 (CHEBI:77983), consuming ATP and a proton."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2794/comments/2""}]"	"[{""id"": ""UniProtKB:Q06685"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06685 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-090_2d3699609f31	gomodel:2.7.1.127-RXN	RO:0002234	CHEBI:57895	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.127-RXN RO:0002234 gomodel:CHEBI_57895_2.7.1.127-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/89; endpoint types: /individuals/166/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-091_6128f550f609	gomodel:YeastPathways_PWY3O-402/6a4c244800000690	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-402/6a4c244800000690 BFO:0000066 gomodel:YeastPathways_PWY3O-402/6a4c244800000696."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/90; endpoint types: /individuals/171/type; /individuals/176/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-092_ee207e5fa134	gomodel:RXN-7162	RO:0002234	CHEBI:16322	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7162 RO:0002234 gomodel:CHEBI_16322_RXN-7162."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/91; endpoint types: /individuals/56/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-093_329b758c9f4a	gomodel:RXN-7162	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-7162 RO:0002233 gomodel:CHEBI_30616_RXN-7162."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/92; endpoint types: /individuals/56/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-095_f7860a66afa9	gomodel:2.7.1.152-RXN	RO:0002234	CHEBI:58628	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.152-RXN RO:0002234 gomodel:CHEBI_58628_2.7.1.152-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/94; endpoint types: /individuals/168/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-096_f02b23725bc6	gomodel:RXN3O-143	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-143 RO:0002233 gomodel:CHEBI_30616_RXN3O-143."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/95; endpoint types: /individuals/59/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-097_16c9c181badc	gomodel:2.7.1.151-RXN	RO:0002234	CHEBI:57627	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:2.7.1.151-RXN RO:0002234 gomodel:CHEBI_57627_2.7.1.151-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/96; endpoint types: /individuals/167/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-098_1e58f15c9c16	gomodel:RXN3O-786	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-786 RO:0002234 gomodel:CHEBI_43474_RXN3O-786."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/97; endpoint types: /individuals/62/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-099_097ccd22ef06	gomodel:RXN3O-9819	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9819 BFO:0000066 gomodel:reaction_RXN3O-9819_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/98; endpoint types: /individuals/63/type; /individuals/165/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-100_93de4c18b5c9	gomodel:RXN-4941	RO:0002233	CHEBI:16322	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN-4941 RO:0002233 gomodel:CHEBI_16322_RXN-7184."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/99; endpoint types: /individuals/55/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-101_d25741ba5220	gomodel:RXN3O-143	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-143 RO:0002234 gomodel:CHEBI_456216_RXN3O-143."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/100; endpoint types: /individuals/59/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-102_ea7c598fb972	gomodel:RXN3O-143	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-143 BFO:0000066 gomodel:reaction_RXN3O-143_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/101; endpoint types: /individuals/59/type; /individuals/161/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-103_42b3509a0d13	gomodel:RXN3O-785	RO:0002234	CHEBI:58130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-785 RO:0002234 gomodel:CHEBI_58130_RXN3O-785."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/102; endpoint types: /individuals/61/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-104_02b022f78a32	SGD:S000002424	pathwaymech:enables	gomodel:YeastPathways_PWY3O-402/6a4c244800000690	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-402/6a4c244800000690 RO:0002333 gomodel:YeastPathways_PWY3O-402/6a4c244800000695."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/103; endpoint types: /individuals/171/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_edge-105_844d8b0a1bdd	gomodel:RXN3O-258	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-402		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_assertion"": ""The model asserts gomodel:RXN3O-258 BFO:0000066 gomodel:reaction_RXN3O-258_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-402.json#/facts/104; endpoint types: /individuals/60/type; /individuals/162/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-402"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json"", ""title"": ""SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_location-5214c2b390ca_20fb09541d0a	SGD:S000002424	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12494	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q12494"", ""source_assertion"": ""UniProtKB:Q12494 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3127/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q12494"", ""source_assertion"": ""UniProtKB:Q12494 has the exact SGD cross-reference SGD:S000002424."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3127/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q12494"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12494 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_location-87721e43eca9_4d21049bd2f9	SGD:S000002723	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06667	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10390371)	"[{""reference_id"": ""UniProtKB:Q06667"", ""source_assertion"": ""UniProtKB:Q06667 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4206/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q06667"", ""source_assertion"": ""UniProtKB:Q06667 has the exact SGD cross-reference SGD:S000002723."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4206/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q06667"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06667 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_location-fb640fb92d05_81a9b7c6859d	SGD:S000005689	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q99321	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q99321"", ""source_assertion"": ""UniProtKB:Q99321 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3200/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q99321"", ""source_assertion"": ""UniProtKB:Q99321 has the exact SGD cross-reference SGD:S000005689."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3200/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q99321"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q99321 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_location-1afcddf76504_3efbb9e03925	SGD:S000005689	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q99321	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q99321"", ""source_assertion"": ""UniProtKB:Q99321 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3200/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q99321"", ""source_assertion"": ""UniProtKB:Q99321 has the exact SGD cross-reference SGD:S000005689."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3200/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q99321"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q99321 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_location-f95048335e40_0276dc8e9e14	SGD:S000002580	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07250	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10632874); ECO:0000269 (PubMed:16123124); ECO:0000269 (PubMed:3311884)	"[{""reference_id"": ""UniProtKB:P07250"", ""source_assertion"": ""UniProtKB:P07250 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/164/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07250"", ""source_assertion"": ""UniProtKB:P07250 has the exact SGD cross-reference SGD:S000002580."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/164/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07250"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07250 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_location-05a8324fb900_31764e229f53	SGD:S000004402	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06685	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q06685"", ""source_assertion"": ""UniProtKB:Q06685 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2794/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q06685"", ""source_assertion"": ""UniProtKB:Q06685 has the exact SGD cross-reference SGD:S000004402."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2794/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q06685"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06685 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_location-f79e9a0f8048_4210682d0400	SGD:S000004402	RO:0001025	GO:0005856	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06685	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q06685"", ""source_assertion"": ""UniProtKB:Q06685 annotates location Cytoplasm, cytoskeleton (SL-0090)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2794/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q06685"", ""source_assertion"": ""UniProtKB:Q06685 has the exact SGD cross-reference SGD:S000004402."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2794/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q06685"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06685 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_RXN3O-143-proton_237fd8078aac	gomodel:RXN3O-143	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06685		"[{""reference_id"": ""UniProtKB:Q06685"", ""source_assertion"": ""Vip1 RHEA:10276 phosphorylates 5-IP7 to 1,5-IP8 (CHEBI:77983), consuming ATP and a proton."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2794/comments/2""}]"	"[{""id"": ""UniProtKB:Q06685"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06685 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_RXN3O-9819-proton_b0e5d13505b4	gomodel:RXN3O-9819	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12494		"[{""reference_id"": ""UniProtKB:Q12494"", ""source_assertion"": ""Kcs1 RHEA:37467 adds the 5-position diphosphate to 1-IP7 (CHEBI:74946), producing 1,5-IP8 (CHEBI:77983)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3127/comments/2""}]"	"[{""id"": ""UniProtKB:Q12494"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12494 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_Kcs1-1IP7-kinase_e7339510bcc2	SGD:S000002424	pathwaymech:enables	gomodel:RXN3O-9819	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12494		"[{""reference_id"": ""UniProtKB:Q12494"", ""source_assertion"": ""Kcs1 RHEA:37467 adds the 5-position diphosphate to 1-IP7 (CHEBI:74946), producing 1,5-IP8 (CHEBI:77983)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3127/comments/2""}]"	"[{""id"": ""UniProtKB:Q12494"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12494 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_Vip1-1IP7-phosphatase_70d199c76e4a	SGD:S000004402	pathwaymech:enables	RHEA:79724	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:32303658	In-vitro recombinant pyrophosphatase-domain activity; no cellular flux or S. pombe phenotype is projected onto S. cerevisiae.	"[{""reference_id"": ""PMID:32303658"", ""source_assertion"": ""The recombinant S. cerevisiae Vip1 pyrophosphatase domain hydrolyzes 1-IP7 but not 3-IP7 in vitro. This is domain-assay evidence, not an assertion of physiological flux."", ""source_locator"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7196807/fullTextXML [sha256:3e4daf11de27f7571fd524187c26585c63365169c80143be547437354180a0c9] //sec[@id='s5']/p[2]; //sec[@id='s5']/p[3]; //fig[@id='fig03']; Table 2""}]"	"[{""id"": ""PMID:32303658"", ""source_sha256"": ""3e4daf11de27f7571fd524187c26585c63365169c80143be547437354180a0c9"", ""title"": ""Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7196807/fullTextXML""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_Vip1-hydrolysis-has_input-74946_9e4c6a31aea6	RHEA:79724	RO:0002233	CHEBI:74946	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:79724		"[{""reference_id"": ""RHEA:79724"", ""source_assertion"": ""RHEA:79724 hydrolyzes 1-IP7 and water to inositol hexakisphosphate, phosphate and a proton."", ""source_locator"": ""Rhea release 139 RDF: 79724 side 79723_L; contains/compound/accession CHEBI:74946""}]"	"[{""id"": ""RHEA:79724"", ""source_version"": ""139"", ""title"": ""Rhea 1-IP7 hydrolysis reaction"", ""url"": ""https://www.rhea-db.org/rhea/79724""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_Vip1-hydrolysis-has_input-15377_8c2093d6d3db	RHEA:79724	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:79724		"[{""reference_id"": ""RHEA:79724"", ""source_assertion"": ""RHEA:79724 hydrolyzes 1-IP7 and water to inositol hexakisphosphate, phosphate and a proton."", ""source_locator"": ""Rhea release 139 RDF: 79724 side 79723_L; contains/compound/accession CHEBI:15377""}]"	"[{""id"": ""RHEA:79724"", ""source_version"": ""139"", ""title"": ""Rhea 1-IP7 hydrolysis reaction"", ""url"": ""https://www.rhea-db.org/rhea/79724""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_Vip1-hydrolysis-has_output-58130_3e6414fc91bd	RHEA:79724	RO:0002234	CHEBI:58130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:79724		"[{""reference_id"": ""RHEA:79724"", ""source_assertion"": ""RHEA:79724 hydrolyzes 1-IP7 and water to inositol hexakisphosphate, phosphate and a proton."", ""source_locator"": ""Rhea release 139 RDF: 79724 side 79723_R; contains/compound/accession CHEBI:58130""}]"	"[{""id"": ""RHEA:79724"", ""source_version"": ""139"", ""title"": ""Rhea 1-IP7 hydrolysis reaction"", ""url"": ""https://www.rhea-db.org/rhea/79724""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_Vip1-hydrolysis-has_output-43474_fbad00166bd4	RHEA:79724	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:79724		"[{""reference_id"": ""RHEA:79724"", ""source_assertion"": ""RHEA:79724 hydrolyzes 1-IP7 and water to inositol hexakisphosphate, phosphate and a proton."", ""source_locator"": ""Rhea release 139 RDF: 79724 side 79723_R; contains/compound/accession CHEBI:43474""}]"	"[{""id"": ""RHEA:79724"", ""source_version"": ""139"", ""title"": ""Rhea 1-IP7 hydrolysis reaction"", ""url"": ""https://www.rhea-db.org/rhea/79724""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_Vip1-hydrolysis-has_output-15378_ba52d497e3d2	RHEA:79724	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:79724		"[{""reference_id"": ""RHEA:79724"", ""source_assertion"": ""RHEA:79724 hydrolyzes 1-IP7 and water to inositol hexakisphosphate, phosphate and a proton."", ""source_locator"": ""Rhea release 139 RDF: 79724 side 79723_R; contains/compound/accession CHEBI:15378""}]"	"[{""id"": ""RHEA:79724"", ""source_version"": ""139"", ""title"": ""Rhea 1-IP7 hydrolysis reaction"", ""url"": ""https://www.rhea-db.org/rhea/79724""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_cofactor-6747d214b2cf_4a1d26ba06bc	SGD:S000005689	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q99321	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10085096); ECO:0000269 (PubMed:31175919); ECO:0000269 (PubMed:33893105) Binds 3 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:O95989); ECO:0000305 (PubMed:33893105)	"[{""reference_id"": ""UniProtKB:Q99321"", ""source_assertion"": ""UniProtKB:Q99321 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3200/comments/0/cofactors/0; /results/3200/comments/0/note""}, {""reference_id"": ""UniProtKB:Q99321"", ""source_assertion"": ""UniProtKB:Q99321 has the exact SGD cross-reference SGD:S000005689."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3200/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q99321"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q99321 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_cofactor-e994b59d7897_de818078c830	SGD:S000005689	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q99321	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10085096) Binds 3 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:O95989); ECO:0000305 (PubMed:33893105)	"[{""reference_id"": ""UniProtKB:Q99321"", ""source_assertion"": ""UniProtKB:Q99321 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3200/comments/0/cofactors/1; /results/3200/comments/0/note""}, {""reference_id"": ""UniProtKB:Q99321"", ""source_assertion"": ""UniProtKB:Q99321 has the exact SGD cross-reference SGD:S000005689."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3200/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q99321"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q99321 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_cofactor-448e1ce4eec7_bfa3b77fc3d1	SGD:S000005689	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q99321	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:31175919) Binds 3 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:O95989); ECO:0000305 (PubMed:33893105)	"[{""reference_id"": ""UniProtKB:Q99321"", ""source_assertion"": ""UniProtKB:Q99321 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3200/comments/0/cofactors/2; /results/3200/comments/0/note""}, {""reference_id"": ""UniProtKB:Q99321"", ""source_assertion"": ""UniProtKB:Q99321 has the exact SGD cross-reference SGD:S000005689."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3200/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q99321"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q99321 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-402_cofactor-8c1e5281d7cf_5616b47b18d0	SGD:S000006189	pathwaymech:has_cofactor	CHEBI:29108	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32383	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:8395015)	"[{""reference_id"": ""UniProtKB:P32383"", ""source_assertion"": ""UniProtKB:P32383 annotates CHEBI:29108 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/898/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P32383"", ""source_assertion"": ""UniProtKB:P32383 has the exact SGD cross-reference SGD:S000006189."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/898/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32383"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P32383 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-1_a804cdaedc49	CHEBI:58045	pathwaymech:consumes	WikiPathways:WP178/id59c25f71	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML id59c25f71 connects normalized CHEBI:58045 as an input of interaction id59c25f71."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id59c25f71']/Graphics; /Pathway/DataNode[@GraphId='a702d']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-2_ddf100972b39	WikiPathways:WP178/id59c25f71	pathwaymech:produces	CHEBI:35146	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML id59c25f71 connects normalized CHEBI:35146 as an output of interaction id59c25f71."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id59c25f71']/Graphics; /Pathway/DataNode[@GraphId='f7ede']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-3_13451352892b	CHEBI:16182	pathwaymech:consumes	WikiPathways:WP178/idbcd10869	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML idbcd10869 connects normalized CHEBI:16182 as an input of interaction idbcd10869."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idbcd10869']/Graphics; /Pathway/DataNode[@GraphId='ae17b']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-4_4d8426deba0e	WikiPathways:WP178/idbcd10869	pathwaymech:produces	CHEBI:48945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML idbcd10869 connects normalized CHEBI:48945 as an output of interaction idbcd10869."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idbcd10869']/Graphics; /Pathway/DataNode[@GraphId='ec74f']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-5_5a0102959d68	CHEBI:35146	pathwaymech:consumes	WikiPathways:WP178/idf1c4befb	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML idf1c4befb connects normalized CHEBI:35146 as an input of interaction idf1c4befb."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idf1c4befb']/Graphics; /Pathway/DataNode[@GraphId='f7ede']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-6_f4a690fc7688	WikiPathways:WP178/idf1c4befb	pathwaymech:produces	CHEBI:16182	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML idf1c4befb connects normalized CHEBI:16182 as an output of interaction idf1c4befb."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idf1c4befb']/Graphics; /Pathway/DataNode[@GraphId='ae17b']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-7_3d85b8b043d3	WikiPathways:WP178/idf1c4befb	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML id122c722 connects normalized CHEBI:16526 as an output of interaction idf1c4befb."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id122c722']/Graphics; /Pathway/DataNode[@GraphId='f1acf']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-8_e0fc5166d93b	SGD:S000002327	pathwaymech:catalyzes	WikiPathways:WP178/idbcd10869	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML id3c6e83b4 connects normalized SGD:S000002327 as a catalyst of interaction idbcd10869."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id3c6e83b4']/Graphics; /Pathway/DataNode[@GraphId='ef0ef']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-9_9dd90e810fd9	SGD:S000000349	pathwaymech:catalyzes	WikiPathways:WP178/idbcd10869	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML id3c6e83b4 connects normalized SGD:S000000349 as a catalyst of interaction idbcd10869."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id3c6e83b4']/Graphics; /Pathway/DataNode[@GraphId='afbec']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-10_bc30f1e97084	SGD:S000003225	pathwaymech:catalyzes	WikiPathways:WP178/idbcd10869	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML id3c6e83b4 connects normalized SGD:S000003225 as a catalyst of interaction idbcd10869."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id3c6e83b4']/Graphics; /Pathway/DataNode[@GraphId='ee6f3']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-11_7c39bf50b95e	SGD:S000003909	pathwaymech:catalyzes	WikiPathways:WP178/id59c25f71	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML id6ce772fa connects normalized SGD:S000003909 as a catalyst of interaction id59c25f71."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id6ce772fa']/Graphics; /Pathway/DataNode[@GraphId='a9a']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-12_ac8cb266e85e	SGD:S000001251	pathwaymech:catalyzes	WikiPathways:WP178/id59c25f71	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML id6ce772fa connects normalized SGD:S000001251 as a catalyst of interaction id59c25f71."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id6ce772fa']/Graphics; /Pathway/DataNode[@GraphId='b88']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-13_ec1b52ceefde	CHEBI:57945	pathwaymech:consumes	WikiPathways:WP178/idbcd10869	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML id6d78e0dd connects normalized CHEBI:57945 as an input of interaction idbcd10869."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id6d78e0dd']/Graphics; /Pathway/DataNode[@GraphId='bc33d']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-14_6770d0cf639d	WikiPathways:WP178/idbcd10869	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML id7aa61fb4 connects normalized CHEBI:57540 as an output of interaction idbcd10869."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id7aa61fb4']/Graphics; /Pathway/DataNode[@GraphId='b6044']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-15_025af44db4c9	SGD:S000004034	pathwaymech:catalyzes	WikiPathways:WP178/idf1c4befb	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML id88f86b02 connects normalized SGD:S000004034 as a catalyst of interaction idf1c4befb."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id88f86b02']/Graphics; /Pathway/DataNode[@GraphId='beb']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-16_433bcd6810af	SGD:S000002788	pathwaymech:catalyzes	WikiPathways:WP178/idf1c4befb	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML id88f86b02 connects normalized SGD:S000002788 as a catalyst of interaction idf1c4befb."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id88f86b02']/Graphics; /Pathway/DataNode[@GraphId='d89']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-17_315069ae798b	SGD:S000003319	pathwaymech:catalyzes	WikiPathways:WP178/idf1c4befb	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML id88f86b02 connects normalized SGD:S000003319 as a catalyst of interaction idf1c4befb."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id88f86b02']/Graphics; /Pathway/DataNode[@GraphId='da5']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-18_4cc2f19d6712	SGD:S000004124	pathwaymech:catalyzes	WikiPathways:WP178/idf1c4befb	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML id88f86b02 connects normalized SGD:S000004124 as a catalyst of interaction idf1c4befb."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id88f86b02']/Graphics; /Pathway/DataNode[@GraphId='e36']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-19_e072a1d7fe01	CHEBI:16810	pathwaymech:consumes	WikiPathways:WP178/id59c25f71	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML idb65db85 connects normalized CHEBI:16810 as an input of interaction id59c25f71."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idb65db85']/Graphics; /Pathway/DataNode[@GraphId='e2f2a']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-20_523a2b200f61	WikiPathways:WP178/id59c25f71	pathwaymech:produces	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML idba75f623 connects normalized CHEBI:29985 as an output of interaction id59c25f71."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idba75f623']/Graphics; /Pathway/DataNode[@GraphId='d5f']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_causal-review-21_fd7b582eef08	CHEBI:15378	pathwaymech:consumes	WikiPathways:WP178/idf1c4befb	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP178		"[{""reference_id"": ""WikiPathways:WP178"", ""source_assertion"": ""GPML ide5cba93b connects normalized CHEBI:15378 as an input of interaction idf1c4befb."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ide5cba93b']/Graphics; /Pathway/DataNode[@GraphId='e284e']""}]"	"[{""id"": ""WikiPathways:WP178"", ""source_sha256"": ""0c35c1496de594e094238fafc4efeaef88075546da521b2c0dcbf04f6e5ccb39"", ""source_version"": ""WP178_r140283"", ""title"": ""WP178 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP178/WP178.gpml""}]"	""
pathwaymech:WikiPathways_WP178_cofactor-41b7855c2473_514bbb6eb817	SGD:S000003909	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47176	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P47176"", ""source_assertion"": ""UniProtKB:P47176 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1987/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P47176"", ""source_assertion"": ""UniProtKB:P47176 has the exact SGD cross-reference SGD:S000003909."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1987/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P47176"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P47176 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP178_cofactor-2ed218c0aed2_7d80626b318c	SGD:S000001251	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38891	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: Disputed growth phenotypes do not address PLP binding; retain the similarity-based PLP annotation. UniProt evidence: ECO:0000250 (UniProtKB:P0AB80)	"[{""reference_id"": ""UniProtKB:P38891"", ""source_assertion"": ""UniProtKB:P38891 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1497/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P38891"", ""source_assertion"": ""UniProtKB:P38891 has the exact SGD cross-reference SGD:S000001251."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1497/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38891"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P38891 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP178_cofactor-81ce8a7e7be7_1f10abeed459	SGD:S000004034	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06169	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10651824) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000269 (PubMed:10651824)	"[{""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/comments/0/cofactors/0; /results/127/comments/0/note""}, {""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P06169"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P06169 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP178_cofactor-5cf6d8babbe2_b57ffd99b77d	SGD:S000004034	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06169	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10651824) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000269 (PubMed:10651824)	"[{""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/comments/1/cofactors/0; /results/127/comments/1/note""}, {""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P06169"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P06169 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP178_cofactor-94921f5c2d4f_bc81e6d0df7c	SGD:S000002788	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06408	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/comments/0/cofactors/0; /results/2752/comments/0/note""}, {""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 has the exact SGD cross-reference SGD:S000002788."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q06408"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB Q06408 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP178_cofactor-2aff8723af5a_a5b8f7cb0f7c	SGD:S000002788	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06408	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/comments/1/cofactors/0; /results/2752/comments/1/note""}, {""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 has the exact SGD cross-reference SGD:S000002788."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q06408"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB Q06408 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP178_cofactor-437eea628a9f_20af6935a28f	SGD:S000003319	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26263	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/comments/0/cofactors/0; /results/742/comments/0/note""}, {""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P26263"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P26263 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP178_cofactor-be7459c89012_996444c88ff2	SGD:S000003319	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26263	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/comments/1/cofactors/0; /results/742/comments/1/note""}, {""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P26263"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P26263 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP178_cofactor-93748e431c03_ab1d9bc179fe	SGD:S000004124	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16467	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/comments/0/cofactors/0; /results/439/comments/0/note""}, {""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P16467"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P16467 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP178_cofactor-43ef6e61857d_c89c144832e8	SGD:S000004124	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16467	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/comments/1/cofactors/0; /results/439/comments/1/note""}, {""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P16467"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P16467 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP178_cofactor-5ec0450d58bc_a3361487879d	SGD:S000002327	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32771	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06525) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06525)	"[{""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/990/comments/0/cofactors/0; /results/990/comments/0/note""}, {""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/990/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32771"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P32771 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP178_cofactor-339a304fe175_8742e5022273	SGD:S000000349	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38113	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	"[{""reference_id"": ""UniProtKB:P38113"", ""source_assertion"": ""UniProtKB:P38113 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3563/comments/0/cofactors/0; /results/3563/comments/0/note""}, {""reference_id"": ""UniProtKB:P38113"", ""source_assertion"": ""UniProtKB:P38113 has the exact SGD cross-reference SGD:S000000349."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3563/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38113"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P38113 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP178_cofactor-a5e2dcd48dc5_8550dde28c9f	SGD:S000003225	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10127	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3282541) Zinc. May bind iron when zinc levels are limiting. UniProt note evidence: ECO:0000269 (PubMed:3282541)	"[{""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/comments/0/cofactors/0; /results/302/comments/0/note""}, {""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P10127"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P10127 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP178_cofactor-ae583f346b28_8799db075f3c	SGD:S000003225	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10127	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3282541) Zinc. May bind iron when zinc levels are limiting. UniProt note evidence: ECO:0000269 (PubMed:3282541)	"[{""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 annotates CHEBI:29033 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/comments/0/cofactors/1; /results/302/comments/0/note""}, {""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P10127"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P10127 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-001_72caa8e0fcf1	CHEBI:58052	pathwaymech:consumes	RHEA:24703	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24703		"[{""reference_id"": ""RHEA:24703"", ""source_assertion"": ""RHEA:24703 assigns CHEBI:58052 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24703']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24702_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24702_compound_3253']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3253)""}]"	"[{""id"": ""RHEA:24703"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24703 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-002_953af968f9d9	CHEBI:57540	pathwaymech:consumes	RHEA:24703	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24703		"[{""reference_id"": ""RHEA:24703"", ""source_assertion"": ""RHEA:24703 assigns CHEBI:57540 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24703']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24702_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24702_compound_3484']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3484)""}]"	"[{""id"": ""RHEA:24703"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24703 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-003_e7d82c2eb485	RHEA:24703	pathwaymech:produces	CHEBI:58710	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24703		"[{""reference_id"": ""RHEA:24703"", ""source_assertion"": ""RHEA:24703 assigns CHEBI:58710 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24703']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24702_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24702_compound_5229']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5229)""}]"	"[{""id"": ""RHEA:24703"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24703 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-004_02816ac49078	RHEA:24703	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24703		"[{""reference_id"": ""RHEA:24703"", ""source_assertion"": ""RHEA:24703 assigns CHEBI:16526 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24703']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24702_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24702_compound_4391']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_4391)""}]"	"[{""id"": ""RHEA:24703"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24703 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-005_2fd08d641ee9	RHEA:24703	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24703		"[{""reference_id"": ""RHEA:24703"", ""source_assertion"": ""RHEA:24703 assigns CHEBI:57945 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24703']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24702_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24702_compound_1650']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_1650)""}]"	"[{""id"": ""RHEA:24703"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24703 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-006_0eac36eb8de4	RHEA:24703	BFO:0000050	MetaCyc:PWY0-1338	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1338|MetaCyc:RXN0-1861|RHEA:24703		"[{""reference_id"": ""MetaCyc:PWY0-1338"", ""source_assertion"": ""The native pathway explicitly includes RXN0-1861 in its six-reaction list."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY0-1338\""]/reaction-list/Reaction[@frameid=\""RXN0-1861\""]""}, {""reference_id"": ""MetaCyc:RXN0-1861"", ""source_assertion"": ""The native reaction carries the Rhea cross-reference 24703."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN0-1861\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:24703"", ""source_assertion"": ""Rhea master 24702 links directed reaction 24703; the selected orientation is left_to_right."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24702']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/24703']""}]"	"[{""id"": ""MetaCyc:PWY0-1338"", ""source_sha256"": ""8195b8b215493ff2f9ef2871fa734087b799c3664a72d14148fd3e274c948dcb"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc PWY0-1338 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1338""}, {""id"": ""MetaCyc:RXN0-1861"", ""source_sha256"": ""fe22516fae73af538c9659844c4d3c71af6250eb711c6836dbd97a58cbd45db4"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc RXN0-1861 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-1861""}, {""id"": ""RHEA:24703"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24703 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-007_fab2bc0efb8c	CHEBI:58710	pathwaymech:consumes	RHEA:24712	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24712		"[{""reference_id"": ""RHEA:24712"", ""source_assertion"": ""RHEA:24712 assigns CHEBI:58710 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24712']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24710_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24710_compound_5229']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5229)""}]"	"[{""id"": ""RHEA:24712"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24712 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-008_4dd9829d0dc7	CHEBI:29985	pathwaymech:consumes	RHEA:24712	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24712		"[{""reference_id"": ""RHEA:24712"", ""source_assertion"": ""RHEA:24712 assigns CHEBI:29985 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24712']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24710_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24710_compound_2079']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_2079)""}]"	"[{""id"": ""RHEA:24712"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24712 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-009_eadd306226ca	RHEA:24712	pathwaymech:produces	CHEBI:58708	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24712		"[{""reference_id"": ""RHEA:24712"", ""source_assertion"": ""RHEA:24712 assigns CHEBI:58708 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24712']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24710_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24710_compound_5232']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5232)""}]"	"[{""id"": ""RHEA:24712"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24712 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-010_0d27bae1e16e	RHEA:24712	pathwaymech:produces	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24712		"[{""reference_id"": ""RHEA:24712"", ""source_assertion"": ""RHEA:24712 assigns CHEBI:16810 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24712']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24710_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24710_compound_2975']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_2975)""}]"	"[{""id"": ""RHEA:24712"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24712 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-011_7355a028dba2	RHEA:24712	BFO:0000050	MetaCyc:PWY0-1338	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1338|MetaCyc:RXN0-1863|RHEA:24712		"[{""reference_id"": ""MetaCyc:PWY0-1338"", ""source_assertion"": ""The native pathway explicitly includes RXN0-1863 in its six-reaction list."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY0-1338\""]/reaction-list/Reaction[@frameid=\""RXN0-1863\""]""}, {""reference_id"": ""MetaCyc:RXN0-1863"", ""source_assertion"": ""The native reaction carries the Rhea cross-reference 24713."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN0-1863\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:24712"", ""source_assertion"": ""Rhea master 24710 links directed reaction 24712; the selected orientation is right_to_left."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24710']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/24712']""}, {""reference_id"": ""RHEA:24712"", ""source_assertion"": ""Rhea master 24710 explicitly links native bidirectional cross-reference 24713 and the selected biosynthetic right-to-left reaction 24712."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24710']/rh:bidirectionalReaction; rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:PWY0-1338"", ""source_sha256"": ""8195b8b215493ff2f9ef2871fa734087b799c3664a72d14148fd3e274c948dcb"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc PWY0-1338 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1338""}, {""id"": ""MetaCyc:RXN0-1863"", ""source_sha256"": ""c5fa2b1cfeb3708c7d8de5486bc419be380ee526e74d8c698c008a8fcc544cbf"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc RXN0-1863 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-1863""}, {""id"": ""RHEA:24712"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24712 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-012_40863f9aee81	CHEBI:58708	pathwaymech:consumes	RHEA:24707	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24707		"[{""reference_id"": ""RHEA:24707"", ""source_assertion"": ""RHEA:24707 assigns CHEBI:58708 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24707']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24706_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24706_compound_5232']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5232)""}]"	"[{""id"": ""RHEA:24707"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24707 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-013_e22972fea807	CHEBI:195366	pathwaymech:consumes	RHEA:24707	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24707		"[{""reference_id"": ""RHEA:24707"", ""source_assertion"": ""RHEA:24707 assigns CHEBI:195366 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24707']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24706_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24706_compound_18717']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_18717)""}]"	"[{""id"": ""RHEA:24707"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24707 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-014_1624eefe0dd2	RHEA:24707	pathwaymech:produces	CHEBI:58709	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24707		"[{""reference_id"": ""RHEA:24707"", ""source_assertion"": ""RHEA:24707 assigns CHEBI:58709 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24707']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24706_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24706_compound_5231']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5231)""}]"	"[{""id"": ""RHEA:24707"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24707 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-015_25f2e389118b	RHEA:24707	pathwaymech:produces	CHEBI:57453	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24707		"[{""reference_id"": ""RHEA:24707"", ""source_assertion"": ""RHEA:24707 assigns CHEBI:57453 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24707']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24706_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24706_compound_4996']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_4996)""}]"	"[{""id"": ""RHEA:24707"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24707 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-016_9fb0878b9f0a	RHEA:24707	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24707		"[{""reference_id"": ""RHEA:24707"", ""source_assertion"": ""RHEA:24707 assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24707']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24706_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24706_compound_3249']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3249)""}]"	"[{""id"": ""RHEA:24707"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24707 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-017_edc6055f21cc	RHEA:24707	BFO:0000050	MetaCyc:PWY0-1338	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1338|MetaCyc:RXN0-1862|RHEA:24707	The native folate participants are classes; current Rhea specifies the chemically balanced monoglutamate forms used for this reaction representation.	"[{""reference_id"": ""MetaCyc:PWY0-1338"", ""source_assertion"": ""The native pathway explicitly includes RXN0-1862 in its six-reaction list."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY0-1338\""]/reaction-list/Reaction[@frameid=\""RXN0-1862\""]""}, {""reference_id"": ""MetaCyc:RXN0-1862"", ""source_assertion"": ""The native reaction carries the Rhea cross-reference 24707."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN0-1862\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:24707"", ""source_assertion"": ""Rhea master 24706 links directed reaction 24707; the selected orientation is left_to_right."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24706']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/24707']""}]"	"[{""id"": ""MetaCyc:PWY0-1338"", ""source_sha256"": ""8195b8b215493ff2f9ef2871fa734087b799c3664a72d14148fd3e274c948dcb"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc PWY0-1338 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1338""}, {""id"": ""MetaCyc:RXN0-1862"", ""source_sha256"": ""877331735e9050269c40e20e64d0ce2af19070e01b18642d5ad52e46830ddc46"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc RXN0-1862 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-1862""}, {""id"": ""RHEA:24707"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24707 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-018_2727a3f7cd24	CHEBI:58709	pathwaymech:consumes	RHEA:27723	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27723		"[{""reference_id"": ""RHEA:27723"", ""source_assertion"": ""RHEA:27723 assigns CHEBI:58709 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27723']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27722_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27722_compound_5231']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5231)""}]"	"[{""id"": ""RHEA:27723"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 27723 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-019_4756a9ae7254	CHEBI:60392	pathwaymech:consumes	RHEA:27723	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27723		"[{""reference_id"": ""RHEA:27723"", ""source_assertion"": ""RHEA:27723 assigns CHEBI:60392 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27723']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27722_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27722_compound_6255']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_6255)""}]"	"[{""id"": ""RHEA:27723"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 27723 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-020_4ea90254ec07	RHEA:27723	pathwaymech:produces	CHEBI:58909	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27723		"[{""reference_id"": ""RHEA:27723"", ""source_assertion"": ""RHEA:27723 assigns CHEBI:58909 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27723']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27722_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27722_compound_5985']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5985)""}]"	"[{""id"": ""RHEA:27723"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 27723 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-021_54ee0f83e2be	RHEA:27723	pathwaymech:produces	CHEBI:58223	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27723		"[{""reference_id"": ""RHEA:27723"", ""source_assertion"": ""RHEA:27723 assigns CHEBI:58223 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27723']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27722_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27722_compound_2692']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_2692)""}]"	"[{""id"": ""RHEA:27723"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 27723 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-022_a8b9e87937f6	RHEA:27723	BFO:0000050	MetaCyc:PWY0-1338	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1338|MetaCyc:RXN0-3521|RHEA:27723		"[{""reference_id"": ""MetaCyc:PWY0-1338"", ""source_assertion"": ""The native pathway explicitly includes RXN0-3521 in its six-reaction list."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY0-1338\""]/reaction-list/Reaction[@frameid=\""RXN0-3521\""]""}, {""reference_id"": ""MetaCyc:RXN0-3521"", ""source_assertion"": ""The native reaction carries the Rhea cross-reference 27723."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN0-3521\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:27723"", ""source_assertion"": ""Rhea master 27722 links directed reaction 27723; the selected orientation is left_to_right."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27722']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/27723']""}]"	"[{""id"": ""MetaCyc:PWY0-1338"", ""source_sha256"": ""8195b8b215493ff2f9ef2871fa734087b799c3664a72d14148fd3e274c948dcb"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc PWY0-1338 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1338""}, {""id"": ""MetaCyc:RXN0-3521"", ""source_sha256"": ""5dcb47be389e09338b89b90564ca7e6dc5baa42e1e83e664da479fadfc8d9f0d"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc RXN0-3521 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-3521""}, {""id"": ""RHEA:27723"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 27723 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-023_466b872fd106	CHEBI:58909	pathwaymech:consumes	RHEA:27735	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27735		"[{""reference_id"": ""RHEA:27735"", ""source_assertion"": ""RHEA:27735 assigns CHEBI:58909 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27735']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27734_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27734_compound_5985']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5985)""}]"	"[{""id"": ""RHEA:27735"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 27735 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-024_465ca9eff834	CHEBI:15377	pathwaymech:consumes	RHEA:27735	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27735		"[{""reference_id"": ""RHEA:27735"", ""source_assertion"": ""RHEA:27735 assigns CHEBI:15377 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27735']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27734_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27734_compound_1283']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_1283)""}]"	"[{""id"": ""RHEA:27735"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 27735 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-025_8c37c3fba959	RHEA:27735	pathwaymech:produces	CHEBI:60463	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27735		"[{""reference_id"": ""RHEA:27735"", ""source_assertion"": ""RHEA:27735 assigns CHEBI:60463 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27735']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27734_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27734_compound_6257']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_6257)""}]"	"[{""id"": ""RHEA:27735"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 27735 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-026_8abb44dee0e7	RHEA:27735	pathwaymech:produces	CHEBI:15740	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27735		"[{""reference_id"": ""RHEA:27735"", ""source_assertion"": ""RHEA:27735 assigns CHEBI:15740 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27735']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27734_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27734_compound_3001']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3001)""}]"	"[{""id"": ""RHEA:27735"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 27735 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-027_3ad2caedeb3e	RHEA:27735	BFO:0000050	MetaCyc:PWY0-1338	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1338|MetaCyc:RXN0-5409|PMID:37782650|RHEA:27735	Native 22.5 marks this step hypothetical; later experiments support the transformation. E. coli gene-disruption evidence and purified Salmonella enzyme evidence are distinguished.	"[{""reference_id"": ""MetaCyc:PWY0-1338"", ""source_assertion"": ""The native pathway explicitly includes RXN0-5409 in its six-reaction list."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY0-1338\""]/reaction-list/Reaction[@frameid=\""RXN0-5409\""]""}, {""reference_id"": ""MetaCyc:RXN0-5409"", ""source_assertion"": ""The native reaction carries the Rhea cross-reference 27735."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN0-5409\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:27735"", ""source_assertion"": ""Rhea master 27734 links directed reaction 27735; the selected orientation is left_to_right."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27734']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/27735']""}, {""reference_id"": ""PMID:37782650"", ""source_assertion"": ""Deleting arnD in the E. coli pmrAc background accumulates C55P-Ara4FN; purified Salmonella ArnD converts the substrate to C55P-Ara4N in vitro."", ""source_locator"": ""PMC10914315, Results, P21 and P28; Figures 1D and 5A""}]"	"[{""id"": ""MetaCyc:PWY0-1338"", ""source_sha256"": ""8195b8b215493ff2f9ef2871fa734087b799c3664a72d14148fd3e274c948dcb"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc PWY0-1338 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1338""}, {""id"": ""MetaCyc:RXN0-5409"", ""source_sha256"": ""382da3b94b548e27b99aa92da207257c8323e8825b9c0a11e4b303d2692b8932"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc RXN0-5409 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5409""}, {""id"": ""PMID:37782650"", ""source_sha256"": ""defa6873164e56cf049be420e1fc01d8d6de19e983ea1602dc0eaf0859dc47e7"", ""source_version"": ""Original primary full-text HTML; complete response retrieved 2026-10-11"", ""title"": ""Structure and Function of ArnD. A Deformylase Essential for Lipid A Modification with 4-Amino-4-deoxy-L-arabinose and Polymyxin Resistance"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC10914315/""}, {""id"": ""RHEA:27735"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 27735 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-028_5898b9106d21	CHEBI:60463	pathwaymech:consumes	RHEA:35372	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11535605|RHEA:35372		"[{""reference_id"": ""RHEA:35372"", ""source_assertion"": ""RHEA:35372 assigns CHEBI:60463 to its substrates with coefficient 2."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/35372']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/35371_L']/rh:contains2[@rdf:resource='http://rdf.rhea-db.org/Participant_35371_compound_6257']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_6257)""}, {""reference_id"": ""PMID:11535605"", ""source_assertion"": ""The purified E. coli donor lipid contains one phosphate and an alpha-linked L-Ara4N residue, as established by mass spectrometry and multidimensional NMR."", ""source_locator"": ""/resultList/result[id=\""11535605\""]/abstractText""}]"	"[{""id"": ""PMID:11535605"", ""source_sha256"": ""af355d755c668f3dd2a0fbdd49074b4db5c25ae53dde1acbd5bf1b98f0dc4c85"", ""source_version"": ""Primary abstract via Europe PMC; SHA256 covers the complete eight-PMID API response, indexed by exact result.id"", ""title"": ""Accumulation of a polyisoprene-linked amino sugar in polymyxin-resistant Salmonella typhimurium and Escherichia coli: structural characterization and transfer to lipid A in the periplasm."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/11535605/""}, {""id"": ""RHEA:35372"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 35372 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-029_82d4a32587cf	CHEBI:58540	pathwaymech:consumes	RHEA:35372	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35372		"[{""reference_id"": ""RHEA:35372"", ""source_assertion"": ""RHEA:35372 assigns CHEBI:58540 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/35372']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/35371_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_35371_compound_5227']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5227)""}]"	"[{""id"": ""RHEA:35372"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 35372 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-030_ce44b7fa68a5	RHEA:35372	pathwaymech:produces	CHEBI:71399	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35372		"[{""reference_id"": ""RHEA:35372"", ""source_assertion"": ""RHEA:35372 assigns CHEBI:71399 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/35372']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/35371_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_35371_compound_7725']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_7725)""}]"	"[{""id"": ""RHEA:35372"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 35372 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-031_9c7e485deb39	RHEA:35372	pathwaymech:produces	CHEBI:60392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35372		"[{""reference_id"": ""RHEA:35372"", ""source_assertion"": ""RHEA:35372 assigns CHEBI:60392 to its products with coefficient 2."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/35372']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/35371_R']/rh:contains2[@rdf:resource='http://rdf.rhea-db.org/Participant_35371_compound_6255']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_6255)""}]"	"[{""id"": ""RHEA:35372"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 35372 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-032_8f82ff628b4e	RHEA:35372	BFO:0000050	MetaCyc:PWY0-1338	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1338|MetaCyc:RXN0-2001|RHEA:35372	The current balanced equation represents two transfers to a Kdo-disaccharide-bearing lipid-A substrate. It does not impose double modification on every lipid-A molecule.	"[{""reference_id"": ""MetaCyc:PWY0-1338"", ""source_assertion"": ""The native pathway explicitly includes RXN0-2001 in its six-reaction list."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY0-1338\""]/reaction-list/Reaction[@frameid=\""RXN0-2001\""]""}, {""reference_id"": ""MetaCyc:RXN0-2001"", ""source_assertion"": ""The native reaction carries the Rhea cross-reference 35372."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN0-2001\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:35372"", ""source_assertion"": ""Rhea master 35371 links directed reaction 35372; the selected orientation is left_to_right."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/35371']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/35372']""}]"	"[{""id"": ""MetaCyc:PWY0-1338"", ""source_sha256"": ""8195b8b215493ff2f9ef2871fa734087b799c3664a72d14148fd3e274c948dcb"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc PWY0-1338 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1338""}, {""id"": ""MetaCyc:RXN0-2001"", ""source_sha256"": ""4c2dbdedcfc128530faacfa2a424f3b8ddf56519a49e45a0975c5b35ec2a8342"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc RXN0-2001 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-2001""}, {""id"": ""RHEA:35372"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 35372 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-033_ca44b8d88b8f	UniProtKB:P77398	BFO:0000050	MetaCyc:CPLX0-7718	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7718|PMID:15939024|PMID:31344437|UniProtKB:P77398	The named native hexamer represents the experimentally characterized assembly, not an exclusive oligomeric state or a claim that isolated domains are inactive.	"[{""reference_id"": ""MetaCyc:CPLX0-7718"", ""source_assertion"": ""The native complex contains six G7168-MONOMER subunits."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""CPLX0-7718\""]/component/Protein; component/coefficient""}, {""reference_id"": ""UniProtKB:P77398"", ""source_assertion"": ""SUBUNIT annotates a homohexamer, a dimer of trimers, with ECO:0000269 evidence from PMID15809294 and PMID15939024."", ""source_locator"": ""/comments/7/texts/0""}, {""reference_id"": ""PMID:15939024"", ""source_assertion"": ""The full-length E. coli structure is a hexamer assembled as a dimer of trimers; crystal forms independently contain the same hexameric unit."", ""source_locator"": ""PMC2997725, Results and Discussion, P8 and P10; Figure 2""}, {""reference_id"": ""PMID:31344437"", ""source_assertion"": ""The inspected abstract reports both hexameric and tetrameric ArnA cryo-EM architectures and proposes an oligomeric equilibrium."", ""source_locator"": ""/resultList/result[id=\""31344437\""]/abstractText""}]"	"[{""id"": ""MetaCyc:CPLX0-7718"", ""source_sha256"": ""158e0b1bbcbf4e9bf495f4b362af8d3d878bcd87787c12061459839492c508ac"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc CPLX0-7718 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7718""}, {""id"": ""PMID:15939024"", ""source_sha256"": ""d2c6183e66acb4916f10304b61bdaceeee12a060f102df8425f1f11bf94ca874"", ""source_version"": ""Original primary full-text HTML; complete response retrieved 2026-10-11"", ""title"": ""Structure and Mechanism of ArnA: Conformational Change Implies Ordered Dehydrogenase Mechanism in Key Enzyme for Polymyxin Resistance"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2997725/""}, {""id"": ""PMID:31344437"", ""source_sha256"": ""af355d755c668f3dd2a0fbdd49074b4db5c25ae53dde1acbd5bf1b98f0dc4c85"", ""source_version"": ""Primary abstract via Europe PMC; SHA256 covers the complete eight-PMID API response, indexed by exact result.id"", ""title"": ""Cryo-electron microscopy structures of ArnA, a key enzyme for polymyxin resistance, revealed unexpected oligomerizations and domain movements."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/31344437/""}, {""id"": ""UniProtKB:P77398"", ""source_sha256"": ""36e4bca5addd5af9e038ef557dd03bc5fba76a456cd38373ae2c84595d14edb2"", ""source_version"": ""UniProt 2026_03; complete native JSON response retrieved 2026-10-11"", ""title"": ""Bifunctional polymyxin resistance protein ArnA"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77398.json""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-034_984c253f028a	MetaCyc:CPLX0-7718	pathwaymech:catalyzes	RHEA:24703	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7718|PMID:15807526|PMID:15939024|UniProtKB:P77398	NAD+ is a consumed and reduced substrate, not a permanently bound cofactor; ATP used in the crystal structure is a NAD+ mimic.	"[{""reference_id"": ""MetaCyc:CPLX0-7718"", ""source_assertion"": ""The native ArnA complex catalyzes the enzyme reaction linked to RXN0-1861."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""CPLX0-7718\""]/catalyzes/Enzymatic-Reaction/reaction/Reaction[@frameid=\""RXN0-1861\""]""}, {""reference_id"": ""UniProtKB:P77398"", ""source_assertion"": ""CATALYTIC ACTIVITY assigns NAD-dependent UDP-glucuronate oxidative decarboxylation (RHEA:24702; ECO:0000269), with physiological direction 24703."", ""source_locator"": ""/comments/1/reaction; /comments/1/physiologicalReactions/0""}, {""reference_id"": ""PMID:15807526"", ""source_assertion"": ""Purified ArnA C-terminal domain converts UDP-glucuronate with NAD+ to the UDP-ketopentose used in the coupled ArnB reaction."", ""source_locator"": ""PMC2583347, Materials and Methods, Thin-Layer Chromatography Assays, P14""}, {""reference_id"": ""PMID:15939024"", ""source_assertion"": ""ATP is a structural mimic in the crystal; NAD+ binds, is reduced and is released as NADH as a true substrate."", ""source_locator"": ""PMC2997725, P17 and P29""}]"	"[{""id"": ""MetaCyc:CPLX0-7718"", ""source_sha256"": ""158e0b1bbcbf4e9bf495f4b362af8d3d878bcd87787c12061459839492c508ac"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc CPLX0-7718 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7718""}, {""id"": ""PMID:15807526"", ""source_sha256"": ""af0780185012898d41ea89cc9445d20819c5a3b873544c9eb704c0822ab05f34"", ""source_version"": ""Original primary full-text HTML; complete response retrieved 2026-10-11"", ""title"": ""Crystal Structure and Mechanism of the Escherichia coli ArnA (PmrI) Transformylase Domain. An Enzyme for Lipid A Modification with 4-Amino-4-deoxy-L-arabinose and Polymyxin Resistance"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2583347/""}, {""id"": ""PMID:15939024"", ""source_sha256"": ""d2c6183e66acb4916f10304b61bdaceeee12a060f102df8425f1f11bf94ca874"", ""source_version"": ""Original primary full-text HTML; complete response retrieved 2026-10-11"", ""title"": ""Structure and Mechanism of ArnA: Conformational Change Implies Ordered Dehydrogenase Mechanism in Key Enzyme for Polymyxin Resistance"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2997725/""}, {""id"": ""UniProtKB:P77398"", ""source_sha256"": ""36e4bca5addd5af9e038ef557dd03bc5fba76a456cd38373ae2c84595d14edb2"", ""source_version"": ""UniProt 2026_03; complete native JSON response retrieved 2026-10-11"", ""title"": ""Bifunctional polymyxin resistance protein ArnA"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77398.json""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-035_47497452b856	UniProtKB:P77690	pathwaymech:enables	RHEA:24712	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12704196|UniProtKB:P77690	Biosynthetic flux selects the Rhea right-to-left direction of a reversible aminotransferase. The functional gene-product role does not assert monomer sufficiency; the E. coli dimer annotation is by similarity.	"[{""reference_id"": ""UniProtKB:P77690"", ""source_assertion"": ""FUNCTION assigns production of UDP-aminoarabinose, and CATALYTIC ACTIVITY cites the reversible RHEA:24710 equation (ECO:0000269; PMID12704196)."", ""source_locator"": ""/comments/0/texts/0; /comments/1/reaction""}, {""reference_id"": ""PMID:12704196"", ""source_assertion"": ""Purified E. coli ArnB reversibly transfers the glutamate amino group to the UDP-ketopentose; NMR confirms the product, and the equilibrium constant toward UDP-aminoarabinose is about 0.1."", ""source_locator"": ""/resultList/result[id=\""12704196\""]/abstractText""}, {""reference_id"": ""UniProtKB:P77690"", ""source_assertion"": ""The homodimer SUBUNIT annotation is transferred by similarity from Salmonella Q8ZNF3 (ECO:0000250)."", ""source_locator"": ""/comments/5/texts/0""}]"	"[{""id"": ""PMID:12704196"", ""source_sha256"": ""af355d755c668f3dd2a0fbdd49074b4db5c25ae53dde1acbd5bf1b98f0dc4c85"", ""source_version"": ""Primary abstract via Europe PMC; SHA256 covers the complete eight-PMID API response, indexed by exact result.id"", ""title"": ""Origin of lipid A species modified with 4-amino-4-deoxy-L-arabinose in polymyxin-resistant mutants of Escherichia coli. An aminotransferase (ArnB) that generates UDP-4-deoxyl-L-arabinose."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12704196/""}, {""id"": ""UniProtKB:P77690"", ""source_sha256"": ""3c485fe28cb92c345c6196be97f63196e39c51020ea2fe480b60f22e37586c88"", ""source_version"": ""UniProt 2026_03; complete native JSON response retrieved 2026-10-11"", ""title"": ""UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77690.json""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-036_80e1bc6c775e	MetaCyc:CPLX0-7718	pathwaymech:catalyzes	RHEA:24707	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7718|PMID:15807526|UniProtKB:P77398	Folate is the formyl-donating substrate. Active isolated domains do not establish that a hexamer is mandatory for either chemistry.	"[{""reference_id"": ""MetaCyc:CPLX0-7718"", ""source_assertion"": ""The native ArnA complex catalyzes the enzyme reaction linked to RXN0-1862."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""CPLX0-7718\""]/catalyzes/Enzymatic-Reaction/reaction/Reaction[@frameid=\""RXN0-1862\""]""}, {""reference_id"": ""UniProtKB:P77398"", ""source_assertion"": ""CATALYTIC ACTIVITY assigns formyl transfer from (6R)-10-formyltetrahydrofolate to UDP-aminoarabinose (RHEA:24706; ECO:0000269); physiological direction is 24707."", ""source_locator"": ""/comments/2/reaction; /comments/2/physiologicalReactions/0""}, {""reference_id"": ""PMID:15807526"", ""source_assertion"": ""The isolated E. coli N-terminal domain retains transformylation activity; assays add N10-formyltetrahydrofolate to the UDP-aminoarabinose substrate."", ""source_locator"": ""PMC2583347, Materials and Methods P14-P16; Results and Discussion P17-P19""}]"	"[{""id"": ""MetaCyc:CPLX0-7718"", ""source_sha256"": ""158e0b1bbcbf4e9bf495f4b362af8d3d878bcd87787c12061459839492c508ac"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc CPLX0-7718 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7718""}, {""id"": ""PMID:15807526"", ""source_sha256"": ""af0780185012898d41ea89cc9445d20819c5a3b873544c9eb704c0822ab05f34"", ""source_version"": ""Original primary full-text HTML; complete response retrieved 2026-10-11"", ""title"": ""Crystal Structure and Mechanism of the Escherichia coli ArnA (PmrI) Transformylase Domain. An Enzyme for Lipid A Modification with 4-Amino-4-deoxy-L-arabinose and Polymyxin Resistance"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2583347/""}, {""id"": ""UniProtKB:P77398"", ""source_sha256"": ""36e4bca5addd5af9e038ef557dd03bc5fba76a456cd38373ae2c84595d14edb2"", ""source_version"": ""UniProt 2026_03; complete native JSON response retrieved 2026-10-11"", ""title"": ""Bifunctional polymyxin resistance protein ArnA"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77398.json""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-037_db04790e5c53	UniProtKB:P77757	pathwaymech:enables	RHEA:27723	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:G7167-MONOMER|PMID:15695810|PMID:37782650|PMID:39865303|UniProtKB:P77757	Functional E. coli ArnC role. The later Salmonella tetramer structure and Mn-containing assays are not evidence for a fixed E. coli oligomer or its physiological metal.	"[{""reference_id"": ""UniProtKB:P77757"", ""source_assertion"": ""CATALYTIC ACTIVITY assigns transfer of formamidoarabinose from UDP to undecaprenyl phosphate (RHEA:27722; ECO:0000269; PMID15695810)."", ""source_locator"": ""/comments/1/reaction""}, {""reference_id"": ""PMID:15695810"", ""source_assertion"": ""Only the formylated sugar nucleotide is converted in vitro to an undecaprenyl-phosphate-linked form by ArnC."", ""source_locator"": ""/resultList/result[id=\""15695810\""]/abstractText""}, {""reference_id"": ""MetaCyc:G7167-MONOMER"", ""source_assertion"": ""The native comment distinguishes ArnC utilization of UDP-L-Ara4FN from failure to utilize unformylated UDP-L-Ara4N."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""G7167-MONOMER\""]/comment""}, {""reference_id"": ""PMID:39865303"", ""source_assertion"": ""The cryo-EM study uses Salmonella Typhimurium ArnC and observes apo and UDP-bound tetramers; this is not direct evidence for E. coli quaternary structure."", ""source_locator"": ""PMC11761694, sections 2.1 (pro70037-sec-0003), 3.2 (pro70037-sec-0008) and 3.3 (pro70037-sec-0009)""}, {""reference_id"": ""PMID:37782650"", ""source_assertion"": ""Substrate synthesis uses purified Salmonella ArnC in a reaction mixture containing MnCl2."", ""source_locator"": ""PMC10914315, Materials and Methods P19""}]"	"[{""id"": ""MetaCyc:G7167-MONOMER"", ""source_sha256"": ""9dcae2b09456b9aae2515545290fe549bd3e640533e97243c45417a0215195a6"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc G7167-MONOMER original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G7167-MONOMER""}, {""id"": ""PMID:15695810"", ""source_sha256"": ""af355d755c668f3dd2a0fbdd49074b4db5c25ae53dde1acbd5bf1b98f0dc4c85"", ""source_version"": ""Primary abstract via Europe PMC; SHA256 covers the complete eight-PMID API response, indexed by exact result.id"", ""title"": ""A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/15695810/""}, {""id"": ""PMID:37782650"", ""source_sha256"": ""defa6873164e56cf049be420e1fc01d8d6de19e983ea1602dc0eaf0859dc47e7"", ""source_version"": ""Original primary full-text HTML; complete response retrieved 2026-10-11"", ""title"": ""Structure and Function of ArnD. A Deformylase Essential for Lipid A Modification with 4-Amino-4-deoxy-L-arabinose and Polymyxin Resistance"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC10914315/""}, {""id"": ""PMID:39865303"", ""source_sha256"": ""5f7d7923cca00a15cb29b4363b53e84cc9fc8e3c737634004c96f3b0a711ee3c"", ""source_version"": ""Original primary full-text HTML; complete response retrieved 2026-10-11"", ""title"": ""Cryo‐EM SPR structures of Salmonella typhimurium ArnC; the key enzyme in lipid‐A modification conferring polymyxin resistance"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC11761694/""}, {""id"": ""UniProtKB:P77757"", ""source_sha256"": ""43bab446c547f984161c16c54a795ce50fe1a64e900e2712636e8fa731b8d66a"", ""source_version"": ""UniProt 2026_03; complete native JSON response retrieved 2026-10-11"", ""title"": ""Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77757.json""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-038_964e63c223e1	UniProtKB:P76472	pathwaymech:enables	RHEA:27735	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:37782650|UniProtKB:P76472	E. coli activity assignment is supported by genetics plus the reviewed annotation and separately scoped Salmonella biochemistry. No E. coli physiological metal or fixed assembly is asserted.	"[{""reference_id"": ""UniProtKB:P76472"", ""source_assertion"": ""FUNCTION still labels deformylation probable (ECO:0000305); CATALYTIC ACTIVITY assigns RHEA:27734 with HAMAP and older PMID15695810 annotations."", ""source_locator"": ""/comments/0/texts/0; /comments/1/reaction""}, {""reference_id"": ""PMID:37782650"", ""source_assertion"": ""E. coli K-12 pmrAc strain MST100 lacking arnD accumulates the formylated C55P-Ara4FN intermediate, supporting the cellular ArnD role."", ""source_locator"": ""PMC10914315, Materials and Methods P10; Results P21; Figure 1D""}, {""reference_id"": ""PMID:37782650"", ""source_assertion"": ""Purified Salmonella Typhimurium ArnD deformylates the C55 donor; EDTA inhibition and Mn2+/Co2+ restoration or stimulation establish metal dependence in those assays."", ""source_locator"": ""PMC10914315, Results P28-P30; Figure 5A""}]"	"[{""id"": ""PMID:37782650"", ""source_sha256"": ""defa6873164e56cf049be420e1fc01d8d6de19e983ea1602dc0eaf0859dc47e7"", ""source_version"": ""Original primary full-text HTML; complete response retrieved 2026-10-11"", ""title"": ""Structure and Function of ArnD. A Deformylase Essential for Lipid A Modification with 4-Amino-4-deoxy-L-arabinose and Polymyxin Resistance"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC10914315/""}, {""id"": ""UniProtKB:P76472"", ""source_sha256"": ""fbfe21f476d6775db4e85de2230b40da4f198b45b5fb8c3c2cc51fc479df1e31"", ""source_version"": ""UniProt 2026_03; complete native JSON response retrieved 2026-10-11"", ""title"": ""Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD"", ""url"": ""https://rest.uniprot.org/uniprotkb/P76472.json""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-039_0ce3670f1499	UniProtKB:P76473	pathwaymech:enables	RHEA:35372	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:G7170-MONOMER|PMID:11535604|PMID:17928292|UniProtKB:P76473	Functional E. coli transferase role with native Kdo2-lipid-A substrate scope. The terminal equation is a two-transfer net reaction; the one-transfer lipid-IVA assay is an alternative substrate reaction, not this equation.	"[{""reference_id"": ""MetaCyc:G7170-MONOMER"", ""source_assertion"": ""The native E. coli ArnT protein links its catalyzed enzyme reaction to RXN0-2001; its comment states that the Salmonella enzyme was studied more extensively."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""G7170-MONOMER\""]/catalyzes/Enzymatic-Reaction/reaction; comment""}, {""reference_id"": ""UniProtKB:P76473"", ""source_assertion"": ""FUNCTION assigns L-Ara4N transfer from the lipid-linked donor to lipid A (ECO:0000269; PMID11535604). Its catalytic text specifically describes the lipid-IVA alternative."", ""source_locator"": ""/comments/0/texts/0; /comments/1/reaction""}, {""reference_id"": ""PMID:11535604"", ""source_assertion"": ""The study reports two L-Ara4N additions to lipid-A precursors containing a Kdo disaccharide, but only one addition to lipid IVA lacking Kdo; ArnT homologs were assigned in E. coli and Salmonella."", ""source_locator"": ""/resultList/result[id=\""11535604\""]/abstractText""}, {""reference_id"": ""PMID:17928292"", ""source_assertion"": ""Deletion of arnT in the E. coli pmrAc background abolishes lipid-A modification without the decreased donor accessibility observed for arnE/arnF mutants."", ""source_locator"": ""PMC2613183, Results, ArnT Is Not Involved in the Transport of Undecaprenyl Phosphate-alpha-L-Ara4N, P36""}]"	"[{""id"": ""MetaCyc:G7170-MONOMER"", ""source_sha256"": ""a6681d82e204286e1a922c9a6dd938fa91f1d7fc6145b4b85f8c2f0279775d0c"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc G7170-MONOMER original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G7170-MONOMER""}, {""id"": ""PMID:11535604"", ""source_sha256"": ""af355d755c668f3dd2a0fbdd49074b4db5c25ae53dde1acbd5bf1b98f0dc4c85"", ""source_version"": ""Primary abstract via Europe PMC; SHA256 covers the complete eight-PMID API response, indexed by exact result.id"", ""title"": ""An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-L-arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/11535604/""}, {""id"": ""PMID:17928292"", ""source_sha256"": ""fbb6494f08a60b6fac2cbd9837e1825dad159d0ec15c3aff24b10225de8b73d8"", ""source_version"": ""Original primary full-text HTML; complete response retrieved 2026-10-11"", ""title"": ""An Undecaprenyl Phosphate-Aminoarabinose Flippase Required for Polymyxin Resistance in Escherichia coli"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2613183/""}, {""id"": ""UniProtKB:P76473"", ""source_sha256"": ""24423c0390a75dbe06eecfc52fa6c47a93dee972979fa796d206dfbac5a44196"", ""source_version"": ""UniProt 2026_03; complete native JSON response retrieved 2026-10-11"", ""title"": ""Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P76473.json""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-040_21c07d3e5172	UniProtKB:P77690	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12704196|UniProtKB:P77690		"[{""reference_id"": ""UniProtKB:P77690"", ""source_assertion"": ""The COFACTOR field identifies pyridoxal 5-prime-phosphate."", ""source_locator"": ""/comments/2/cofactors/0""}, {""reference_id"": ""PMID:12704196"", ""source_assertion"": ""Purified E. coli ArnB contains pyridoxal phosphate detected spectrophotometrically; excess glutamate converts it to the pyridoxamine form."", ""source_locator"": ""/resultList/result[id=\""12704196\""]/abstractText""}]"	"[{""id"": ""PMID:12704196"", ""source_sha256"": ""af355d755c668f3dd2a0fbdd49074b4db5c25ae53dde1acbd5bf1b98f0dc4c85"", ""source_version"": ""Primary abstract via Europe PMC; SHA256 covers the complete eight-PMID API response, indexed by exact result.id"", ""title"": ""Origin of lipid A species modified with 4-amino-4-deoxy-L-arabinose in polymyxin-resistant mutants of Escherichia coli. An aminotransferase (ArnB) that generates UDP-4-deoxyl-L-arabinose."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12704196/""}, {""id"": ""UniProtKB:P77690"", ""source_sha256"": ""3c485fe28cb92c345c6196be97f63196e39c51020ea2fe480b60f22e37586c88"", ""source_version"": ""UniProt 2026_03; complete native JSON response retrieved 2026-10-11"", ""title"": ""UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77690.json""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-041_c3e42e171f09	UniProtKB:Q47377	pathwaymech:enables	MetaCyc:PWY0-1338	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:17928292|UniProtKB:Q47377	Transport-associated pathway role jointly requiring ArnE and ArnF in the studied mutant background; neither edge asserts individual sufficiency, an established physical heterodimer, or direct catalysis of a glycosyltransfer reaction.	"[{""reference_id"": ""UniProtKB:Q47377"", ""source_assertion"": ""FUNCTION assigns transfer of the aminoarabinose-phosphoundecaprenol donor from cytoplasmic to periplasmic side of the inner membrane (ECO:0000269; PMID17928292)."", ""source_locator"": ""/comments/0/texts/0""}, {""reference_id"": ""PMID:17928292"", ""source_assertion"": ""Deleting either arnE or arnF reduces donor accessibility to an impermeable probe and restores sensitivity in the pmrAc parent; heterodimer formation and energy coupling remain proposals."", ""source_locator"": ""PMC2613183, Results P34-P36; Discussion P39-P40 and P45""}]"	"[{""id"": ""PMID:17928292"", ""source_sha256"": ""fbb6494f08a60b6fac2cbd9837e1825dad159d0ec15c3aff24b10225de8b73d8"", ""source_version"": ""Original primary full-text HTML; complete response retrieved 2026-10-11"", ""title"": ""An Undecaprenyl Phosphate-Aminoarabinose Flippase Required for Polymyxin Resistance in Escherichia coli"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2613183/""}, {""id"": ""UniProtKB:Q47377"", ""source_sha256"": ""6bdd3dbe17e7d3a07ae1b9aa9295c472ae2d11349246c2d3f88fba48cd36cf4f"", ""source_version"": ""UniProt 2026_03; complete native JSON response retrieved 2026-10-11"", ""title"": ""Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q47377.json""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-042_517adab56f50	UniProtKB:P76474	pathwaymech:enables	MetaCyc:PWY0-1338	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:17928292|UniProtKB:P76474	Transport-associated pathway role jointly requiring ArnE and ArnF in the studied mutant background; neither edge asserts individual sufficiency, an established physical heterodimer, or direct catalysis of a glycosyltransfer reaction.	"[{""reference_id"": ""UniProtKB:P76474"", ""source_assertion"": ""FUNCTION assigns transfer of the aminoarabinose-phosphoundecaprenol donor from cytoplasmic to periplasmic side of the inner membrane (ECO:0000269; PMID17928292)."", ""source_locator"": ""/comments/0/texts/0""}, {""reference_id"": ""PMID:17928292"", ""source_assertion"": ""Deleting either arnE or arnF reduces donor accessibility to an impermeable probe and restores sensitivity in the pmrAc parent; heterodimer formation and energy coupling remain proposals."", ""source_locator"": ""PMC2613183, Results P34-P36; Discussion P39-P40 and P45""}]"	"[{""id"": ""PMID:17928292"", ""source_sha256"": ""fbb6494f08a60b6fac2cbd9837e1825dad159d0ec15c3aff24b10225de8b73d8"", ""source_version"": ""Original primary full-text HTML; complete response retrieved 2026-10-11"", ""title"": ""An Undecaprenyl Phosphate-Aminoarabinose Flippase Required for Polymyxin Resistance in Escherichia coli"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2613183/""}, {""id"": ""UniProtKB:P76474"", ""source_sha256"": ""4fc10347b3d0f00c815ec5981e52fc2b5a854652dbd6da21bdea690288877ad3"", ""source_version"": ""UniProt 2026_03; complete native JSON response retrieved 2026-10-11"", ""title"": ""Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF"", ""url"": ""https://rest.uniprot.org/uniprotkb/P76474.json""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-043_fa1146eb28ad	UniProtKB:P77757	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77757	Inner membrane mapped to the plasma-membrane cellular component; this does not locate the whole pathway in one compartment.	"[{""reference_id"": ""UniProtKB:P77757"", ""source_assertion"": ""SUBCELLULAR LOCATION annotates a multipass cell-inner-membrane protein. This field has no explicit experimental evidence code."", ""source_locator"": ""/comments/4/subcellularLocations/0""}]"	"[{""id"": ""UniProtKB:P77757"", ""source_sha256"": ""43bab446c547f984161c16c54a795ce50fe1a64e900e2712636e8fa731b8d66a"", ""source_version"": ""UniProt 2026_03; complete native JSON response retrieved 2026-10-11"", ""title"": ""Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77757.json""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-044_a33e60a1a41b	UniProtKB:P76473	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P76473	Inner membrane mapped to the plasma-membrane cellular component; this does not locate the whole pathway in one compartment.	"[{""reference_id"": ""UniProtKB:P76473"", ""source_assertion"": ""SUBCELLULAR LOCATION annotates a multipass cell-inner-membrane protein. The location evidence is ECO:0000269, PMID15919996."", ""source_locator"": ""/comments/3/subcellularLocations/0""}]"	"[{""id"": ""UniProtKB:P76473"", ""source_sha256"": ""24423c0390a75dbe06eecfc52fa6c47a93dee972979fa796d206dfbac5a44196"", ""source_version"": ""UniProt 2026_03; complete native JSON response retrieved 2026-10-11"", ""title"": ""Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P76473.json""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-045_6b66067bc841	UniProtKB:P77690	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12704196		"[{""reference_id"": ""PMID:12704196"", ""source_assertion"": ""The abstract identifies ArnB as a cytoplasmic protein purified from an E. coli overproducing strain."", ""source_locator"": ""/resultList/result[id=\""12704196\""]/abstractText""}]"	"[{""id"": ""PMID:12704196"", ""source_sha256"": ""af355d755c668f3dd2a0fbdd49074b4db5c25ae53dde1acbd5bf1b98f0dc4c85"", ""source_version"": ""Primary abstract via Europe PMC; SHA256 covers the complete eight-PMID API response, indexed by exact result.id"", ""title"": ""Origin of lipid A species modified with 4-amino-4-deoxy-L-arabinose in polymyxin-resistant mutants of Escherichia coli. An aminotransferase (ArnB) that generates UDP-4-deoxyl-L-arabinose."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12704196/""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-046_80e346948818	RHEA:24703	RO:0002413	RHEA:24712	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1338|RHEA:24703|RHEA:24712	The shared chemical class is CHEBI:58710.	"[{""reference_id"": ""MetaCyc:PWY0-1338"", ""source_assertion"": ""The pathway orders RXN0-1861 before RXN0-1863."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY0-1338\""]/reaction-ordering[Reaction/@frameid=\""RXN0-1863\""]/predecessor-reactions/Reaction[@frameid=\""RXN0-1861\""]""}, {""reference_id"": ""RHEA:24703"", ""source_assertion"": ""RHEA:24703 assigns CHEBI:58710 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24703']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24702_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24702_compound_5229']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5229)""}, {""reference_id"": ""RHEA:24712"", ""source_assertion"": ""RHEA:24712 assigns CHEBI:58710 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24712']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24710_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24710_compound_5229']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5229)""}]"	"[{""id"": ""MetaCyc:PWY0-1338"", ""source_sha256"": ""8195b8b215493ff2f9ef2871fa734087b799c3664a72d14148fd3e274c948dcb"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc PWY0-1338 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1338""}, {""id"": ""RHEA:24703"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24703 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:24712"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24712 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-047_641e5ad743e0	RHEA:24712	RO:0002413	RHEA:24707	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1338|RHEA:24707|RHEA:24712	The shared chemical class is CHEBI:58708.	"[{""reference_id"": ""MetaCyc:PWY0-1338"", ""source_assertion"": ""The pathway orders RXN0-1863 before RXN0-1862."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY0-1338\""]/reaction-ordering[Reaction/@frameid=\""RXN0-1862\""]/predecessor-reactions/Reaction[@frameid=\""RXN0-1863\""]""}, {""reference_id"": ""RHEA:24712"", ""source_assertion"": ""RHEA:24712 assigns CHEBI:58708 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24712']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24710_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24710_compound_5232']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5232)""}, {""reference_id"": ""RHEA:24707"", ""source_assertion"": ""RHEA:24707 assigns CHEBI:58708 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24707']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24706_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24706_compound_5232']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5232)""}]"	"[{""id"": ""MetaCyc:PWY0-1338"", ""source_sha256"": ""8195b8b215493ff2f9ef2871fa734087b799c3664a72d14148fd3e274c948dcb"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc PWY0-1338 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1338""}, {""id"": ""RHEA:24707"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24707 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:24712"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24712 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-048_c7607f564e23	RHEA:24707	RO:0002413	RHEA:27723	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1338|RHEA:24707|RHEA:27723	The shared chemical class is CHEBI:58709.	"[{""reference_id"": ""MetaCyc:PWY0-1338"", ""source_assertion"": ""The pathway orders RXN0-1862 before RXN0-3521."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY0-1338\""]/reaction-ordering[Reaction/@frameid=\""RXN0-3521\""]/predecessor-reactions/Reaction[@frameid=\""RXN0-1862\""]""}, {""reference_id"": ""RHEA:24707"", ""source_assertion"": ""RHEA:24707 assigns CHEBI:58709 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24707']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24706_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24706_compound_5231']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5231)""}, {""reference_id"": ""RHEA:27723"", ""source_assertion"": ""RHEA:27723 assigns CHEBI:58709 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27723']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27722_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27722_compound_5231']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5231)""}]"	"[{""id"": ""MetaCyc:PWY0-1338"", ""source_sha256"": ""8195b8b215493ff2f9ef2871fa734087b799c3664a72d14148fd3e274c948dcb"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc PWY0-1338 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1338""}, {""id"": ""RHEA:24707"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 24707 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:27723"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 27723 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-049_22ceb4bef4d4	RHEA:27723	RO:0002413	RHEA:27735	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1338|RHEA:27723|RHEA:27735	The shared chemical class is CHEBI:58909.	"[{""reference_id"": ""MetaCyc:PWY0-1338"", ""source_assertion"": ""The pathway orders RXN0-3521 before RXN0-5409."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY0-1338\""]/reaction-ordering[Reaction/@frameid=\""RXN0-5409\""]/predecessor-reactions/Reaction[@frameid=\""RXN0-3521\""]""}, {""reference_id"": ""RHEA:27723"", ""source_assertion"": ""RHEA:27723 assigns CHEBI:58909 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27723']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27722_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27722_compound_5985']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5985)""}, {""reference_id"": ""RHEA:27735"", ""source_assertion"": ""RHEA:27735 assigns CHEBI:58909 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27735']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27734_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27734_compound_5985']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5985)""}]"	"[{""id"": ""MetaCyc:PWY0-1338"", ""source_sha256"": ""8195b8b215493ff2f9ef2871fa734087b799c3664a72d14148fd3e274c948dcb"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc PWY0-1338 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1338""}, {""id"": ""RHEA:27723"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 27723 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:27735"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 27735 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1338_lipid-a-edge-050_05351c597484	RHEA:27735	RO:0002413	RHEA:35372	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1338|PMID:17928292|RHEA:27735|RHEA:35372	The shared chemical class is CHEBI:60463. Donor transport by ArnE/ArnF is required between formation on the cytoplasmic side and ArnT utilization on the periplasmic side; this class-level edge is not direct substrate channeling.	"[{""reference_id"": ""MetaCyc:PWY0-1338"", ""source_assertion"": ""The pathway orders RXN0-5409 before RXN0-2001."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY0-1338\""]/reaction-ordering[Reaction/@frameid=\""RXN0-2001\""]/predecessor-reactions/Reaction[@frameid=\""RXN0-5409\""]""}, {""reference_id"": ""RHEA:27735"", ""source_assertion"": ""RHEA:27735 assigns CHEBI:60463 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27735']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27734_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27734_compound_6257']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_6257)""}, {""reference_id"": ""RHEA:35372"", ""source_assertion"": ""RHEA:35372 assigns CHEBI:60463 to its substrates with coefficient 2."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/35372']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/35371_L']/rh:contains2[@rdf:resource='http://rdf.rhea-db.org/Participant_35371_compound_6257']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_6257)""}, {""reference_id"": ""PMID:17928292"", ""source_assertion"": ""The donor formed on the cytoplasmic side must reach the periplasmic face for ArnT use; deletion and labeling data implicate both ArnE and ArnF."", ""source_locator"": ""PMC2613183, P7-P8, Results P34-P36; Discussion P39-P40""}]"	"[{""id"": ""MetaCyc:PWY0-1338"", ""source_sha256"": ""8195b8b215493ff2f9ef2871fa734087b799c3664a72d14148fd3e274c948dcb"", ""source_version"": ""MetaCyc mirror 22.5; SHA256 covers the complete original XML response"", ""title"": ""MetaCyc PWY0-1338 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1338""}, {""id"": ""PMID:17928292"", ""source_sha256"": ""fbb6494f08a60b6fac2cbd9837e1825dad159d0ec15c3aff24b10225de8b73d8"", ""source_version"": ""Original primary full-text HTML; complete response retrieved 2026-10-11"", ""title"": ""An Undecaprenyl Phosphate-Aminoarabinose Flippase Required for Polymyxin Resistance in Escherichia coli"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2613183/""}, {""id"": ""RHEA:27735"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 27735 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:35372"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers the complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 35372 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-001_f12b9acc8b6c	CHEBI:16880	pathwaymech:consumes	RHEA:22073	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22073		"[{""reference_id"": ""RHEA:22073"", ""source_assertion"": ""Rhea lists CHEBI:16880 on the substrates side of RHEA:22073 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22073']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22073"", ""source_version"": ""139"", ""title"": ""Rhea L-ribulose-5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22073""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-002_755cb41f4a5c	CHEBI:30616	pathwaymech:consumes	RHEA:22073	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22073		"[{""reference_id"": ""RHEA:22073"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:22073 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22073']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22073"", ""source_version"": ""139"", ""title"": ""Rhea L-ribulose-5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22073""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-003_c8c7ffb45af1	RHEA:22073	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22073		"[{""reference_id"": ""RHEA:22073"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:22073 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22073']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22073"", ""source_version"": ""139"", ""title"": ""Rhea L-ribulose-5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22073""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-004_a3549c9a660a	RHEA:22073	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22073		"[{""reference_id"": ""RHEA:22073"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:22073 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22073']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22073"", ""source_version"": ""139"", ""title"": ""Rhea L-ribulose-5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22073""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-005_fade1bfd2b50	RHEA:22073	pathwaymech:produces	CHEBI:58226	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22073		"[{""reference_id"": ""RHEA:22073"", ""source_assertion"": ""Rhea lists CHEBI:58226 on the products side of RHEA:22073 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22073']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22073"", ""source_version"": ""139"", ""title"": ""Rhea L-ribulose-5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22073""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-006_6bae66da0220	CHEBI:40886	pathwaymech:consumes	RHEA:14822	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14822		"[{""reference_id"": ""RHEA:14822"", ""source_assertion"": ""Rhea lists CHEBI:40886 on the substrates side of RHEA:14822 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14822']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14822"", ""source_version"": ""139"", ""title"": ""RHEA:14822 authority record"", ""url"": ""https://www.rhea-db.org/rhea/14822""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-007_b8582c6a360c	RHEA:14822	pathwaymech:produces	CHEBI:16880	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14822		"[{""reference_id"": ""RHEA:14822"", ""source_assertion"": ""Rhea lists CHEBI:16880 on the products side of RHEA:14822 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14822']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14822"", ""source_version"": ""139"", ""title"": ""RHEA:14822 authority record"", ""url"": ""https://www.rhea-db.org/rhea/14822""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-008_d5e46c0eac46	CHEBI:58226	pathwaymech:consumes	RHEA:22369	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22369		"[{""reference_id"": ""RHEA:22369"", ""source_assertion"": ""Rhea lists CHEBI:58226 on the substrates side of RHEA:22369 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22369']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22369"", ""source_version"": ""139"", ""title"": ""RHEA:22369 authority record"", ""url"": ""https://www.rhea-db.org/rhea/22369""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-009_2fd4048cf279	RHEA:22369	pathwaymech:produces	CHEBI:57737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22369		"[{""reference_id"": ""RHEA:22369"", ""source_assertion"": ""Rhea lists CHEBI:57737 on the products side of RHEA:22369 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22369']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22369"", ""source_version"": ""139"", ""title"": ""RHEA:22369 authority record"", ""url"": ""https://www.rhea-db.org/rhea/22369""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-010_3ee92a9ddb47	EC:5.3.1.4	pathwaymech:catalyzes	RHEA:14822	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14821		"[{""reference_id"": ""RHEA:14821"", ""source_assertion"": ""Rhea associates EC:5.3.1.4 with the reaction family containing RHEA:14822."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:14821"", ""source_version"": ""139"", ""title"": ""Rhea L-arabinose isomerase reaction"", ""url"": ""https://www.rhea-db.org/rhea/14821""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-011_4587543a504a	EC:2.7.1.16	pathwaymech:catalyzes	RHEA:22073	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22072		"[{""reference_id"": ""RHEA:22072"", ""source_assertion"": ""Rhea associates EC:2.7.1.16 with the reaction family containing RHEA:22073."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:22072"", ""source_version"": ""139"", ""title"": ""Rhea ribulokinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/22072""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-012_58855539007c	EC:5.1.3.4	pathwaymech:catalyzes	RHEA:22369	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22368		"[{""reference_id"": ""RHEA:22368"", ""source_assertion"": ""Rhea associates EC:5.1.3.4 with the reaction family containing RHEA:22369."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:22368"", ""source_version"": ""139"", ""title"": ""Rhea L-ribulose-5-phosphate 4-epimerase reaction"", ""url"": ""https://www.rhea-db.org/rhea/22368""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-013_ecffb283f99e	RHEA:14822	pathwaymech:precedes	RHEA:22073	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARABCAT-PWY		"[{""reference_id"": ""MetaCyc:ARABCAT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:14822 before RHEA:22073 in this pathway. Shared intermediate: CHEBI:16880."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARABCAT-PWY"", ""source_sha256"": ""4ae7b870e017c650735f464954c905aade143d619ca16c29e9789f9171fb6e66"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arabinose degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARABCAT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-014_37bc5301651d	RHEA:22073	pathwaymech:precedes	RHEA:22369	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARABCAT-PWY		"[{""reference_id"": ""MetaCyc:ARABCAT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:22073 before RHEA:22369 in this pathway. Shared intermediate: CHEBI:58226."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARABCAT-PWY"", ""source_sha256"": ""4ae7b870e017c650735f464954c905aade143d619ca16c29e9789f9171fb6e66"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arabinose degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARABCAT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-015_e77f81daa8fd	UniProtKB:P08202	pathwaymech:enables	RHEA:14822	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08202		"[{""reference_id"": ""UniProtKB:P08202"", ""source_assertion"": ""UniProt annotates UniProtKB:P08202 with catalytic activity for the reaction family of RHEA:14822. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P08202"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P08202 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08202.json""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-016_83eee0a0abef	UniProtKB:P08202	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08202		"[{""reference_id"": ""UniProtKB:P08202"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P08202 (evidence: curated annotation). Binds 1 Mn(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P08202"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P08202 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08202.json""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-017_fd603ace6818	UniProtKB:P08203	pathwaymech:enables	RHEA:22369	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08203		"[{""reference_id"": ""UniProtKB:P08203"", ""source_assertion"": ""UniProt annotates UniProtKB:P08203 with catalytic activity for the reaction family of RHEA:22369. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P08203"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P08203 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08203.json""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-018_b1b7112db589	UniProtKB:P08203	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08203		"[{""reference_id"": ""UniProtKB:P08203"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P08203 (evidence: ECO:0000255, ECO:0000269). Binds 1 zinc ion per subunit (PubMed:10769139, PubMed:11732895, PubMed:11732896, PubMed:9548961). Also able to use cobalt and manganese ions, but less efficiently (PubMed:10769139)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P08203"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P08203 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08203.json""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-019_8f53b9d6522b	UniProtKB:P08204	pathwaymech:enables	RHEA:22073	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08204		"[{""reference_id"": ""UniProtKB:P08204"", ""source_assertion"": ""UniProt annotates UniProtKB:P08204 with catalytic activity for the reaction family of RHEA:22073. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P08204"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P08204 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08204.json""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-020_48e3bc5d72c3	UniProtKB:P37680	pathwaymech:enables	RHEA:22369	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37680		"[{""reference_id"": ""UniProtKB:P37680"", ""source_assertion"": ""UniProt annotates UniProtKB:P37680 with catalytic activity for the reaction family of RHEA:22369. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P37680"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P37680 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37680.json""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-021_341e19c3a2d0	UniProtKB:P37680	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37680		"[{""reference_id"": ""UniProtKB:P37680"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P37680 (evidence: ECO:0000250). Binds 1 zinc ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P37680"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P37680 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37680.json""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-022_3230a79eaf9e	UniProtKB:P39306	pathwaymech:enables	RHEA:22369	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39306		"[{""reference_id"": ""UniProtKB:P39306"", ""source_assertion"": ""UniProt annotates UniProtKB:P39306 with catalytic activity for the reaction family of RHEA:22369. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P39306"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P39306 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P39306.json""}]"	""
pathwaymech:MetaCyc_ARABCAT-PWY_edge-023_38d7eaeba089	UniProtKB:P39306	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39306		"[{""reference_id"": ""UniProtKB:P39306"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P39306 (evidence: ECO:0000250, ECO:0000255). Binds 1 zinc ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P39306"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P39306 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P39306.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-001_016a9a914005	CHEBI:29985	pathwaymech:consumes	RHEA:24293	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24293		"[{""reference_id"": ""RHEA:24293"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the substrates side of RHEA:24293 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24293']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24293"", ""source_version"": ""139"", ""title"": ""Rhea N-acetyl-L-glutamate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24293""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-002_b93366c22550	CHEBI:57288	pathwaymech:consumes	RHEA:24293	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24293		"[{""reference_id"": ""RHEA:24293"", ""source_assertion"": ""Rhea lists CHEBI:57288 on the substrates side of RHEA:24293 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24293']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24293"", ""source_version"": ""139"", ""title"": ""Rhea N-acetyl-L-glutamate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24293""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-003_357904da3539	RHEA:24293	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24293		"[{""reference_id"": ""RHEA:24293"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:24293 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24293']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24293"", ""source_version"": ""139"", ""title"": ""Rhea N-acetyl-L-glutamate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24293""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-004_95fe7edc746f	RHEA:24293	pathwaymech:produces	CHEBI:44337	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24293		"[{""reference_id"": ""RHEA:24293"", ""source_assertion"": ""Rhea lists CHEBI:44337 on the products side of RHEA:24293 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24293']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24293"", ""source_version"": ""139"", ""title"": ""Rhea N-acetyl-L-glutamate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24293""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-005_78775f545e9e	RHEA:24293	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24293		"[{""reference_id"": ""RHEA:24293"", ""source_assertion"": ""Rhea lists CHEBI:57287 on the products side of RHEA:24293 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24293']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24293"", ""source_version"": ""139"", ""title"": ""Rhea N-acetyl-L-glutamate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24293""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-006_73eade4aa0e4	CHEBI:30616	pathwaymech:consumes	RHEA:14630	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14630		"[{""reference_id"": ""RHEA:14630"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:14630 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14630']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14630"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamyl 5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14630""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-007_8876f1738807	CHEBI:44337	pathwaymech:consumes	RHEA:14630	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14630		"[{""reference_id"": ""RHEA:14630"", ""source_assertion"": ""Rhea lists CHEBI:44337 on the substrates side of RHEA:14630 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14630']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14630"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamyl 5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14630""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-008_b1a164ba8ea7	RHEA:14630	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14630		"[{""reference_id"": ""RHEA:14630"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:14630 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14630']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14630"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamyl 5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14630""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-009_500a49628c0b	RHEA:14630	pathwaymech:produces	CHEBI:57936	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14630		"[{""reference_id"": ""RHEA:14630"", ""source_assertion"": ""Rhea lists CHEBI:57936 on the products side of RHEA:14630 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14630']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14630"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamyl 5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14630""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-010_e682699ebfe9	CHEBI:15378	pathwaymech:consumes	RHEA:21590	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21590		"[{""reference_id"": ""RHEA:21590"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:21590 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21590']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21590"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamate 5-semialdehyde-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21590""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-011_702d6f2e00df	CHEBI:57783	pathwaymech:consumes	RHEA:21590	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21590		"[{""reference_id"": ""RHEA:21590"", ""source_assertion"": ""Rhea lists CHEBI:57783 on the substrates side of RHEA:21590 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21590']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21590"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamate 5-semialdehyde-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21590""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-012_09c58f0a9441	CHEBI:57936	pathwaymech:consumes	RHEA:21590	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21590		"[{""reference_id"": ""RHEA:21590"", ""source_assertion"": ""Rhea lists CHEBI:57936 on the substrates side of RHEA:21590 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21590']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21590"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamate 5-semialdehyde-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21590""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-013_e2dae662df51	RHEA:21590	pathwaymech:produces	CHEBI:29123	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21590		"[{""reference_id"": ""RHEA:21590"", ""source_assertion"": ""Rhea lists CHEBI:29123 on the products side of RHEA:21590 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21590']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21590"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamate 5-semialdehyde-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21590""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-014_8e9668a7c8df	RHEA:21590	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21590		"[{""reference_id"": ""RHEA:21590"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:21590 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21590']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21590"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamate 5-semialdehyde-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21590""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-015_aec5dda3dd19	RHEA:21590	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21590		"[{""reference_id"": ""RHEA:21590"", ""source_assertion"": ""Rhea lists CHEBI:58349 on the products side of RHEA:21590 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21590']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21590"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamate 5-semialdehyde-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21590""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-016_2f8a397946d1	CHEBI:29123	pathwaymech:consumes	RHEA:18051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18051		"[{""reference_id"": ""RHEA:18051"", ""source_assertion"": ""Rhea lists CHEBI:29123 on the substrates side of RHEA:18051 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18051']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18051"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-acetyl-L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18051""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-017_ee51853a57ed	CHEBI:29985	pathwaymech:consumes	RHEA:18051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18051		"[{""reference_id"": ""RHEA:18051"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the substrates side of RHEA:18051 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18051']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18051"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-acetyl-L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18051""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-018_1400d8270d81	RHEA:18051	pathwaymech:produces	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18051		"[{""reference_id"": ""RHEA:18051"", ""source_assertion"": ""Rhea lists CHEBI:16810 on the products side of RHEA:18051 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18051']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18051"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-acetyl-L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18051""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-019_2506901a7e39	RHEA:18051	pathwaymech:produces	CHEBI:57805	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18051		"[{""reference_id"": ""RHEA:18051"", ""source_assertion"": ""Rhea lists CHEBI:57805 on the products side of RHEA:18051 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18051']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18051"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-acetyl-L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18051""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-020_697ac445146e	CHEBI:15377	pathwaymech:consumes	RHEA:15942	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15942		"[{""reference_id"": ""RHEA:15942"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:15942 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15942']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15942"", ""source_version"": ""139"", ""title"": ""Rhea L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15942""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-021_d5f5c4f1dc3e	CHEBI:57805	pathwaymech:consumes	RHEA:15942	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15942		"[{""reference_id"": ""RHEA:15942"", ""source_assertion"": ""Rhea lists CHEBI:57805 on the substrates side of RHEA:15942 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15942']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15942"", ""source_version"": ""139"", ""title"": ""Rhea L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15942""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-022_258756d5a177	RHEA:15942	pathwaymech:produces	CHEBI:30089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15942		"[{""reference_id"": ""RHEA:15942"", ""source_assertion"": ""Rhea lists CHEBI:30089 on the products side of RHEA:15942 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15942']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15942"", ""source_version"": ""139"", ""title"": ""Rhea L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15942""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-023_5d410ef7ccc4	RHEA:15942	pathwaymech:produces	CHEBI:46911	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15942		"[{""reference_id"": ""RHEA:15942"", ""source_assertion"": ""Rhea lists CHEBI:46911 on the products side of RHEA:15942 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15942']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15942"", ""source_version"": ""139"", ""title"": ""Rhea L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15942""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-024_4986d60650a7	CHEBI:46911	pathwaymech:consumes	RHEA:19514	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19514		"[{""reference_id"": ""RHEA:19514"", ""source_assertion"": ""Rhea lists CHEBI:46911 on the substrates side of RHEA:19514 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19514']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19514"", ""source_version"": ""139"", ""title"": ""Rhea L-citrulline-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19514""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-025_ad09fc9d6dd7	CHEBI:58228	pathwaymech:consumes	RHEA:19514	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19514		"[{""reference_id"": ""RHEA:19514"", ""source_assertion"": ""Rhea lists CHEBI:58228 on the substrates side of RHEA:19514 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19514']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19514"", ""source_version"": ""139"", ""title"": ""Rhea L-citrulline-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19514""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-026_17d6660978b3	RHEA:19514	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19514		"[{""reference_id"": ""RHEA:19514"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:19514 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19514']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19514"", ""source_version"": ""139"", ""title"": ""Rhea L-citrulline-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19514""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-027_1b5559d5526c	RHEA:19514	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19514		"[{""reference_id"": ""RHEA:19514"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:19514 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19514']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19514"", ""source_version"": ""139"", ""title"": ""Rhea L-citrulline-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19514""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-028_34aa9ae577e0	RHEA:19514	pathwaymech:produces	CHEBI:57743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19514		"[{""reference_id"": ""RHEA:19514"", ""source_assertion"": ""Rhea lists CHEBI:57743 on the products side of RHEA:19514 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19514']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19514"", ""source_version"": ""139"", ""title"": ""Rhea L-citrulline-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19514""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-029_03af00c0eceb	CHEBI:29991	pathwaymech:consumes	RHEA:10933	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10933		"[{""reference_id"": ""RHEA:10933"", ""source_assertion"": ""Rhea lists CHEBI:29991 on the substrates side of RHEA:10933 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10933']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10933"", ""source_version"": ""139"", ""title"": ""Rhea argininosuccinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10933""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-030_a9d92ea58700	CHEBI:30616	pathwaymech:consumes	RHEA:10933	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10933		"[{""reference_id"": ""RHEA:10933"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:10933 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10933']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10933"", ""source_version"": ""139"", ""title"": ""Rhea argininosuccinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10933""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-031_5799f21ed90a	CHEBI:57743	pathwaymech:consumes	RHEA:10933	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10933		"[{""reference_id"": ""RHEA:10933"", ""source_assertion"": ""Rhea lists CHEBI:57743 on the substrates side of RHEA:10933 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10933']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10933"", ""source_version"": ""139"", ""title"": ""Rhea argininosuccinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10933""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-032_e894384506c2	RHEA:10933	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10933		"[{""reference_id"": ""RHEA:10933"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:10933 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10933']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10933"", ""source_version"": ""139"", ""title"": ""Rhea argininosuccinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10933""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-033_ee72b0f09531	RHEA:10933	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10933		"[{""reference_id"": ""RHEA:10933"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:10933 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10933']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10933"", ""source_version"": ""139"", ""title"": ""Rhea argininosuccinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10933""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-034_224e86576dfa	RHEA:10933	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10933		"[{""reference_id"": ""RHEA:10933"", ""source_assertion"": ""Rhea lists CHEBI:456215 on the products side of RHEA:10933 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10933']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10933"", ""source_version"": ""139"", ""title"": ""Rhea argininosuccinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10933""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-035_5bcda02aa652	RHEA:10933	pathwaymech:produces	CHEBI:57472	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10933		"[{""reference_id"": ""RHEA:10933"", ""source_assertion"": ""Rhea lists CHEBI:57472 on the products side of RHEA:10933 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10933']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10933"", ""source_version"": ""139"", ""title"": ""Rhea argininosuccinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10933""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-036_38227f96e525	CHEBI:57472	pathwaymech:consumes	RHEA:24021	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24021		"[{""reference_id"": ""RHEA:24021"", ""source_assertion"": ""Rhea lists CHEBI:57472 on the substrates side of RHEA:24021 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24021']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24021"", ""source_version"": ""139"", ""title"": ""Rhea L-arginine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24021""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-037_e888eaa716ff	RHEA:24021	pathwaymech:produces	CHEBI:29806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24021		"[{""reference_id"": ""RHEA:24021"", ""source_assertion"": ""Rhea lists CHEBI:29806 on the products side of RHEA:24021 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24021']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24021"", ""source_version"": ""139"", ""title"": ""Rhea L-arginine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24021""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-038_214b1e6a57d8	RHEA:24021	pathwaymech:produces	CHEBI:32682	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24021		"[{""reference_id"": ""RHEA:24021"", ""source_assertion"": ""Rhea lists CHEBI:32682 on the products side of RHEA:24021 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24021']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24021"", ""source_version"": ""139"", ""title"": ""Rhea L-arginine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24021""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-039_aeb47012005e	CHEBI:15377	pathwaymech:consumes	RHEA:18634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18634		"[{""reference_id"": ""RHEA:18634"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:18634 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18634']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18634"", ""source_version"": ""139"", ""title"": ""RHEA:18634 authority record"", ""url"": ""https://www.rhea-db.org/rhea/18634""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-040_96b2aa9f231c	CHEBI:17544	pathwaymech:consumes	RHEA:18634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18634		"[{""reference_id"": ""RHEA:18634"", ""source_assertion"": ""Rhea lists CHEBI:17544 on the substrates side of RHEA:18634 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18634']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18634"", ""source_version"": ""139"", ""title"": ""RHEA:18634 authority record"", ""url"": ""https://www.rhea-db.org/rhea/18634""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-041_13da3dc42d22	CHEBI:30616	pathwaymech:consumes	RHEA:18634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18634		"[{""reference_id"": ""RHEA:18634"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:18634 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18634']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18634"", ""source_version"": ""139"", ""title"": ""RHEA:18634 authority record"", ""url"": ""https://www.rhea-db.org/rhea/18634""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-042_c8c1b8dde333	CHEBI:58359	pathwaymech:consumes	RHEA:18634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18634		"[{""reference_id"": ""RHEA:18634"", ""source_assertion"": ""Rhea lists CHEBI:58359 on the substrates side of RHEA:18634 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18634']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18634"", ""source_version"": ""139"", ""title"": ""RHEA:18634 authority record"", ""url"": ""https://www.rhea-db.org/rhea/18634""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-043_cf92b31f5428	RHEA:18634	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18634		"[{""reference_id"": ""RHEA:18634"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:18634 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18634']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18634"", ""source_version"": ""139"", ""title"": ""RHEA:18634 authority record"", ""url"": ""https://www.rhea-db.org/rhea/18634""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-044_f58eee122eab	RHEA:18634	pathwaymech:produces	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18634		"[{""reference_id"": ""RHEA:18634"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the products side of RHEA:18634 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18634']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18634"", ""source_version"": ""139"", ""title"": ""RHEA:18634 authority record"", ""url"": ""https://www.rhea-db.org/rhea/18634""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-045_b00d127a5d81	RHEA:18634	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18634		"[{""reference_id"": ""RHEA:18634"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:18634 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18634']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18634"", ""source_version"": ""139"", ""title"": ""RHEA:18634 authority record"", ""url"": ""https://www.rhea-db.org/rhea/18634""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-046_e2b5f1dd27b5	RHEA:18634	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18634		"[{""reference_id"": ""RHEA:18634"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:18634 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18634']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18634"", ""source_version"": ""139"", ""title"": ""RHEA:18634 authority record"", ""url"": ""https://www.rhea-db.org/rhea/18634""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-047_83278892b5cd	RHEA:18634	pathwaymech:produces	CHEBI:58228	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18634		"[{""reference_id"": ""RHEA:18634"", ""source_assertion"": ""Rhea lists CHEBI:58228 on the products side of RHEA:18634 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18634']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18634"", ""source_version"": ""139"", ""title"": ""RHEA:18634 authority record"", ""url"": ""https://www.rhea-db.org/rhea/18634""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-048_c1ef2e2120fe	EC:2.3.1.1	pathwaymech:catalyzes	RHEA:24293	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24292		"[{""reference_id"": ""RHEA:24292"", ""source_assertion"": ""Rhea associates EC:2.3.1.1 with the reaction family containing RHEA:24293."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:24292"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/24292""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-049_b813683b61bc	EC:2.7.2.8	pathwaymech:catalyzes	RHEA:14630	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14629		"[{""reference_id"": ""RHEA:14629"", ""source_assertion"": ""Rhea associates EC:2.7.2.8 with the reaction family containing RHEA:14630."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:14629"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamate kinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/14629""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-050_70331bb68f6e	EC:1.2.1.38	pathwaymech:catalyzes	RHEA:21590	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21588		"[{""reference_id"": ""RHEA:21588"", ""source_assertion"": ""Rhea associates EC:1.2.1.38 with the reaction family containing RHEA:21590."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:21588"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamyl-phosphate reductase reaction"", ""url"": ""https://www.rhea-db.org/rhea/21588""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-051_09122a5de870	EC:2.6.1.11	pathwaymech:catalyzes	RHEA:18051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18049		"[{""reference_id"": ""RHEA:18049"", ""source_assertion"": ""Rhea associates EC:2.6.1.11 with the reaction family containing RHEA:18051."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:18049"", ""source_version"": ""139"", ""title"": ""Rhea acetylornithine aminotransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/18049""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-052_15f85b3a19b1	EC:3.5.1.16	pathwaymech:catalyzes	RHEA:15942	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15941		"[{""reference_id"": ""RHEA:15941"", ""source_assertion"": ""Rhea associates EC:3.5.1.16 with the reaction family containing RHEA:15942."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:15941"", ""source_version"": ""139"", ""title"": ""Rhea acetylornithine deacetylase reaction"", ""url"": ""https://www.rhea-db.org/rhea/15941""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-053_abda49957c35	EC:2.1.3.3	pathwaymech:catalyzes	RHEA:19514	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19513		"[{""reference_id"": ""RHEA:19513"", ""source_assertion"": ""Rhea associates EC:2.1.3.3 with the reaction family containing RHEA:19514."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:19513"", ""source_version"": ""139"", ""title"": ""Rhea ornithine carbamoyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/19513""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-054_d64578be7eeb	EC:6.3.4.5	pathwaymech:catalyzes	RHEA:10933	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10932		"[{""reference_id"": ""RHEA:10932"", ""source_assertion"": ""Rhea associates EC:6.3.4.5 with the reaction family containing RHEA:10933."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:10932"", ""source_version"": ""139"", ""title"": ""Rhea argininosuccinate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/10932""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-055_23a9b5df07c5	EC:4.3.2.1	pathwaymech:catalyzes	RHEA:24021	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24020		"[{""reference_id"": ""RHEA:24020"", ""source_assertion"": ""Rhea associates EC:4.3.2.1 with the reaction family containing RHEA:24021."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:24020"", ""source_version"": ""139"", ""title"": ""Rhea argininosuccinate lyase reaction"", ""url"": ""https://www.rhea-db.org/rhea/24020""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-056_64c4cb0b2434	EC:6.3.5.5	pathwaymech:catalyzes	RHEA:18634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18633		"[{""reference_id"": ""RHEA:18633"", ""source_assertion"": ""Rhea associates EC:6.3.5.5 with the reaction family containing RHEA:18634."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:18633"", ""source_version"": ""139"", ""title"": ""RHEA:18633 authority record"", ""url"": ""https://www.rhea-db.org/rhea/18633""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-057_f7431e0a3f69	RHEA:10933	pathwaymech:precedes	RHEA:24021	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARGSYN-PWY		"[{""reference_id"": ""MetaCyc:ARGSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:10933 before RHEA:24021 in this pathway. Shared intermediate: CHEBI:57472."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARGSYN-PWY"", ""source_sha256"": ""7ecf3e42d688feaad158be04cf46d3c8f1ccf623293444a1d2405e47deb2c520"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arginine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARGSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-058_5c76681540b9	RHEA:14630	pathwaymech:precedes	RHEA:21590	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARGSYN-PWY		"[{""reference_id"": ""MetaCyc:ARGSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:14630 before RHEA:21590 in this pathway. Shared intermediate: CHEBI:57936."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARGSYN-PWY"", ""source_sha256"": ""7ecf3e42d688feaad158be04cf46d3c8f1ccf623293444a1d2405e47deb2c520"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arginine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARGSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-059_b66f177b11d9	RHEA:15942	pathwaymech:precedes	RHEA:19514	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARGSYN-PWY		"[{""reference_id"": ""MetaCyc:ARGSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:15942 before RHEA:19514 in this pathway. Shared intermediate: CHEBI:46911."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARGSYN-PWY"", ""source_sha256"": ""7ecf3e42d688feaad158be04cf46d3c8f1ccf623293444a1d2405e47deb2c520"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arginine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARGSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-060_e6b7d54d6bb3	RHEA:18051	pathwaymech:precedes	RHEA:15942	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARGSYN-PWY		"[{""reference_id"": ""MetaCyc:ARGSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:18051 before RHEA:15942 in this pathway. Shared intermediate: CHEBI:57805."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARGSYN-PWY"", ""source_sha256"": ""7ecf3e42d688feaad158be04cf46d3c8f1ccf623293444a1d2405e47deb2c520"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arginine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARGSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-061_00d715c5f2a0	RHEA:18634	pathwaymech:precedes	RHEA:19514	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARGSYN-PWY		"[{""reference_id"": ""MetaCyc:ARGSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:18634 before RHEA:19514 in this pathway. Shared intermediate: CHEBI:58228."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARGSYN-PWY"", ""source_sha256"": ""7ecf3e42d688feaad158be04cf46d3c8f1ccf623293444a1d2405e47deb2c520"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arginine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARGSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-062_32a000c039a9	RHEA:19514	pathwaymech:precedes	RHEA:10933	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARGSYN-PWY		"[{""reference_id"": ""MetaCyc:ARGSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:19514 before RHEA:10933 in this pathway. Shared intermediate: CHEBI:57743."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARGSYN-PWY"", ""source_sha256"": ""7ecf3e42d688feaad158be04cf46d3c8f1ccf623293444a1d2405e47deb2c520"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arginine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARGSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-063_461309b19b7d	RHEA:21590	pathwaymech:precedes	RHEA:18051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARGSYN-PWY		"[{""reference_id"": ""MetaCyc:ARGSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:21590 before RHEA:18051 in this pathway. Shared intermediate: CHEBI:29123."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARGSYN-PWY"", ""source_sha256"": ""7ecf3e42d688feaad158be04cf46d3c8f1ccf623293444a1d2405e47deb2c520"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arginine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARGSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-064_53f5c81b3b74	RHEA:24293	pathwaymech:precedes	RHEA:14630	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARGSYN-PWY		"[{""reference_id"": ""MetaCyc:ARGSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:24293 before RHEA:14630 in this pathway. Shared intermediate: CHEBI:44337."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARGSYN-PWY"", ""source_sha256"": ""7ecf3e42d688feaad158be04cf46d3c8f1ccf623293444a1d2405e47deb2c520"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arginine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARGSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-065_2471e5fea410	UniProtKB:P00968	pathwaymech:enables	RHEA:18634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00968		"[{""reference_id"": ""UniProtKB:P00968"", ""source_assertion"": ""UniProt annotates UniProtKB:P00968 with catalytic activity for the reaction family of RHEA:18634. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00968"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00968 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00968.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-066_3b85304e4143	UniProtKB:P00968	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00968		"[{""reference_id"": ""UniProtKB:P00968"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P00968 (evidence: ECO:0000255). Binds 4 Mg(2+) or Mn(2+) ions per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P00968"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00968 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00968.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-067_e19d0c840a96	UniProtKB:P00968	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00968		"[{""reference_id"": ""UniProtKB:P00968"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P00968 (evidence: ECO:0000255, ECO:0000269). Binds 4 Mg(2+) or Mn(2+) ions per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P00968"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00968 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00968.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-068_7115547c9e11	UniProtKB:P04391	pathwaymech:enables	RHEA:19514	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P04391		"[{""reference_id"": ""UniProtKB:P04391"", ""source_assertion"": ""UniProt annotates UniProtKB:P04391 with catalytic activity for the reaction family of RHEA:19514. Annotation evidence: ECO:0000305; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P04391"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P04391 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P04391.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-069_71151c456c5f	UniProtKB:P04391	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P04391		"[{""reference_id"": ""UniProtKB:P04391"", ""source_assertion"": ""UniProt locates UniProtKB:P04391 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P04391"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P04391 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P04391.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-070_972c89fec3d8	UniProtKB:P06960	pathwaymech:enables	RHEA:19514	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06960		"[{""reference_id"": ""UniProtKB:P06960"", ""source_assertion"": ""UniProt annotates UniProtKB:P06960 with catalytic activity for the reaction family of RHEA:19514. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P06960"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P06960 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06960.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-071_d0c0dd8ee979	UniProtKB:P06960	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06960		"[{""reference_id"": ""UniProtKB:P06960"", ""source_assertion"": ""UniProt locates UniProtKB:P06960 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P06960"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P06960 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06960.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-072_2106f34fa861	UniProtKB:P0A6C5	pathwaymech:enables	RHEA:24293	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6C5		"[{""reference_id"": ""UniProtKB:P0A6C5"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A6C5 with catalytic activity for the reaction family of RHEA:24293. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A6C5"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6C5 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6C5.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-073_51104d0958c6	CHEBI:32682	pathwaymech:inhibits	UniProtKB:P0A6C5	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6C5		"[{""reference_id"": ""UniProtKB:P0A6C5"", ""source_assertion"": ""UniProt activity-regulation annotation: Feedback inhibition by L-arginine"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P0A6C5"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6C5 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6C5.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-074_39cc1ad96109	UniProtKB:P0A6C5	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6C5		"[{""reference_id"": ""UniProtKB:P0A6C5"", ""source_assertion"": ""UniProt locates UniProtKB:P0A6C5 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A6C5"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6C5 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6C5.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-075_123d84767a6a	UniProtKB:P0A6C8	pathwaymech:enables	RHEA:14630	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6C8		"[{""reference_id"": ""UniProtKB:P0A6C8"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A6C8 with catalytic activity for the reaction family of RHEA:14630. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A6C8"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6C8 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6C8.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-076_edd04b645159	UniProtKB:P0A6C8	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6C8		"[{""reference_id"": ""UniProtKB:P0A6C8"", ""source_assertion"": ""UniProt locates UniProtKB:P0A6C8 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A6C8"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6C8 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6C8.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-077_f1d66b01ec27	UniProtKB:P0A6E4	pathwaymech:enables	RHEA:10933	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6E4		"[{""reference_id"": ""UniProtKB:P0A6E4"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A6E4 with catalytic activity for the reaction family of RHEA:10933. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A6E4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6E4 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6E4.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-078_1602ecc57b05	UniProtKB:P0A6E4	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6E4		"[{""reference_id"": ""UniProtKB:P0A6E4"", ""source_assertion"": ""UniProt locates UniProtKB:P0A6E4 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A6E4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6E4 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6E4.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-079_dd37fbd9dc6e	UniProtKB:P0A6F1	pathwaymech:enables	RHEA:18634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6F1		"[{""reference_id"": ""UniProtKB:P0A6F1"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A6F1 with catalytic activity for the reaction family of RHEA:18634. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A6F1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6F1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6F1.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-080_a35be791304b	UniProtKB:P11446	pathwaymech:enables	RHEA:21590	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P11446		"[{""reference_id"": ""UniProtKB:P11446"", ""source_assertion"": ""UniProt annotates UniProtKB:P11446 with catalytic activity for the reaction family of RHEA:21590. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P11446"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P11446 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P11446.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-081_8b053cfb4463	UniProtKB:P11446	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P11446		"[{""reference_id"": ""UniProtKB:P11446"", ""source_assertion"": ""UniProt locates UniProtKB:P11446 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P11446"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P11446 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P11446.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-082_5cab9d3d8bbd	UniProtKB:P11447	pathwaymech:enables	RHEA:24021	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P11447		"[{""reference_id"": ""UniProtKB:P11447"", ""source_assertion"": ""UniProt annotates UniProtKB:P11447 with catalytic activity for the reaction family of RHEA:24021. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P11447"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P11447 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P11447.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-083_2cc4aa854cb6	UniProtKB:P11447	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P11447		"[{""reference_id"": ""UniProtKB:P11447"", ""source_assertion"": ""UniProt locates UniProtKB:P11447 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P11447"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P11447 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P11447.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-084_73fe8c944192	UniProtKB:P18335	pathwaymech:enables	RHEA:18051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P18335		"[{""reference_id"": ""UniProtKB:P18335"", ""source_assertion"": ""UniProt annotates UniProtKB:P18335 with catalytic activity for the reaction family of RHEA:18051. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P18335"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P18335 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P18335.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-085_9ea8dd3ba96f	UniProtKB:P18335	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P18335		"[{""reference_id"": ""UniProtKB:P18335"", ""source_assertion"": ""UniProt locates UniProtKB:P18335 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255, ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P18335"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P18335 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P18335.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-086_3e6e70657998	UniProtKB:P18335	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P18335		"[{""reference_id"": ""UniProtKB:P18335"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P18335 (evidence: ECO:0000255, ECO:0000305). Binds 1 pyridoxal phosphate per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P18335"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P18335 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P18335.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-087_801c9609c16f	UniProtKB:P23908	pathwaymech:enables	RHEA:15942	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23908		"[{""reference_id"": ""UniProtKB:P23908"", ""source_assertion"": ""UniProt annotates UniProtKB:P23908 with catalytic activity for the reaction family of RHEA:15942. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P23908"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P23908 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23908.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-088_4ec325c1eeea	UniProtKB:P23908	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23908		"[{""reference_id"": ""UniProtKB:P23908"", ""source_assertion"": ""UniProt locates UniProtKB:P23908 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255, ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P23908"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P23908 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23908.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-089_1c144fbd4bac	UniProtKB:P23908	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23908		"[{""reference_id"": ""UniProtKB:P23908"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P23908 (evidence: ECO:0000255, ECO:0000269). Binds 2 Zn(2+) or Co(2+) ions per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P23908"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P23908 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23908.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-090_51ebae9483f0	UniProtKB:P23908	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23908		"[{""reference_id"": ""UniProtKB:P23908"", ""source_assertion"": ""UniProt lists CHEBI:48828 as a cofactor of UniProtKB:P23908 (evidence: ECO:0000255, ECO:0000269). Binds 2 Zn(2+) or Co(2+) ions per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P23908"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P23908 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23908.json""}]"	""
pathwaymech:MetaCyc_ARGSYN-PWY_edge-091_8f6ee9f0f381	UniProtKB:P23908	pathwaymech:has_cofactor	CHEBI:57925	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23908		"[{""reference_id"": ""UniProtKB:P23908"", ""source_assertion"": ""UniProt lists CHEBI:57925 as a cofactor of UniProtKB:P23908 (evidence: ECO:0000255). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P23908"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P23908 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23908.json""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-001_72e53acf2a70	gomodel:CARBPSYN-RXN	RO:0002233	CHEBI:58359	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002233 gomodel:CHEBI_58359_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/0; endpoint types: /individuals/4/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-002_83d92eacb360	SGD:S000003624	pathwaymech:enables	gomodel:ORNCARBAMTRANSFER-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ORNCARBAMTRANSFER-RXN RO:0002333 gomodel:YJL088W-MONOMER_ORNCARBAMTRANSFER-RXN_controller."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/1; endpoint types: /individuals/48/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-003_8c2419697477	gomodel:ACETYLGLUTKIN-RXN	BFO:0000050	GO:0006526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ACETYLGLUTKIN-RXN BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/2; endpoint types: /individuals/0/type; /individuals/135/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-004_a4d53fff7345	gomodel:ACETYLGLUTKIN-RXN	RO:0002234	CHEBI:57936	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ACETYLGLUTKIN-RXN RO:0002234 gomodel:CHEBI_57936_ACETYLGLUTKIN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/3; endpoint types: /individuals/0/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-005_c2b1031f7bc1	gomodel:CARBPSYN-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002233 gomodel:CHEBI_15377_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/4; endpoint types: /individuals/4/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-006_012d8675ac94	gomodel:ARGSUCCINLYA-RXN	RO:0002234	CHEBI:32682	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ARGSUCCINLYA-RXN RO:0002234 gomodel:CHEBI_32682_ARGSUCCINLYA-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/5; endpoint types: /individuals/2/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-007_d1d3b610d2b6	gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704 RO:0002234 gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000708."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/6; endpoint types: /individuals/136/type; /individuals/140/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-008_38757fc66e03	gomodel:N-ACETYLGLUTPREDUCT-RXN	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:N-ACETYLGLUTPREDUCT-RXN RO:0002234 gomodel:CHEBI_58349_N-ACETYLGLUTPREDUCT-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/7; endpoint types: /individuals/46/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-009_bd06e2308bd0	gomodel:N-ACETYLTRANSFER-RXN	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:N-ACETYLTRANSFER-RXN RO:0002234 gomodel:CHEBI_57287_N-ACETYLTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/8; endpoint types: /individuals/47/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-010_e6ea5c0c2125	SGD:S000217863	BFO:0000051	SGD:S000003870	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:CPLX3O-887_CARBPSYN-RXN_controller BFO:0000051 gomodel:SGD_S000003870_CPLX3O-887_component."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/9; endpoint types: /individuals/44/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-011_cbf09bc601ed	gomodel:CARBPSYN-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002234 gomodel:CHEBI_43474_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/10; endpoint types: /individuals/4/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-013_3b8226ecd36d	gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN	RO:0002233	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_29985_GLUTAMATE-N-ACETYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/12; endpoint types: /individuals/45/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-014_7200a6628a3c	gomodel:ORNCARBAMTRANSFER-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ORNCARBAMTRANSFER-RXN BFO:0000066 gomodel:reaction_ORNCARBAMTRANSFER-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/13; endpoint types: /individuals/48/type; /individuals/134/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-015_c8214163d424	SGD:S000000871	pathwaymech:enables	gomodel:N-ACETYLGLUTPREDUCT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:N-ACETYLGLUTPREDUCT-RXN RO:0002333 gomodel:YER069W-MONOMER_N-ACETYLGLUTPREDUCT-RXN_controller."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/14; endpoint types: /individuals/46/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-016_2c43bdfb267d	gomodel:ORNCARBAMTRANSFER-RXN	RO:0002233	CHEBI:58228	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ORNCARBAMTRANSFER-RXN RO:0002233 gomodel:CHEBI_58228_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/15; endpoint types: /individuals/48/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-017_4ffcd735e620	gomodel:ARGSUCCINLYA-RXN	RO:0002233	CHEBI:57472	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ARGSUCCINLYA-RXN RO:0002233 gomodel:CHEBI_57472_ARGSUCCINSYN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/16; endpoint types: /individuals/2/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-018_61a10e4672da	gomodel:ACETYLORNTRANSAM-RXN	RO:0002234	CHEBI:57805	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ACETYLORNTRANSAM-RXN RO:0002234 gomodel:CHEBI_57805_ACETYLORNTRANSAM-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/17; endpoint types: /individuals/1/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-019_dfe8a39e3ef3	gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN	RO:0002411	gomodel:ACETYLGLUTKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN RO:0002411 gomodel:ACETYLGLUTKIN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/18; endpoint types: /individuals/45/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-020_da2662a4da06	gomodel:ORNCARBAMTRANSFER-RXN	RO:0002233	CHEBI:46911	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ORNCARBAMTRANSFER-RXN RO:0002233 gomodel:CHEBI_46911_GLUTAMATE-N-ACETYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/19; endpoint types: /individuals/48/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-021_f0e688e6a283	gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN	RO:0002233	CHEBI:57805	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_57805_ACETYLORNTRANSAM-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/20; endpoint types: /individuals/45/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-022_2b9c685eac96	gomodel:ORNCARBAMTRANSFER-RXN	BFO:0000050	GO:0006526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ORNCARBAMTRANSFER-RXN BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/21; endpoint types: /individuals/48/type; /individuals/135/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-023_24843e39e756	gomodel:ARGSUCCINSYN-RXN	RO:0002233	CHEBI:57743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ARGSUCCINSYN-RXN RO:0002233 gomodel:CHEBI_57743_ORNCARBAMTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/22; endpoint types: /individuals/3/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-024_e0f75fa6088e	gomodel:N-ACETYLTRANSFER-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:N-ACETYLTRANSFER-RXN RO:0002234 gomodel:CHEBI_15378_N-ACETYLTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/23; endpoint types: /individuals/47/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-025_81bf704f87cb	gomodel:ARGSUCCINSYN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ARGSUCCINSYN-RXN RO:0002234 gomodel:CHEBI_15378_ARGSUCCINSYN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/24; endpoint types: /individuals/3/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-026_051062a873e5	gomodel:CARBPSYN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002234 gomodel:CHEBI_15378_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/25; endpoint types: /individuals/4/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-027_48d24c89904c	gomodel:N-ACETYLGLUTPREDUCT-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:N-ACETYLGLUTPREDUCT-RXN RO:0002234 gomodel:CHEBI_43474_N-ACETYLGLUTPREDUCT-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/26; endpoint types: /individuals/46/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-028_003481b13871	gomodel:ARGSUCCINSYN-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ARGSUCCINSYN-RXN RO:0002234 gomodel:CHEBI_29888_ARGSUCCINSYN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/27; endpoint types: /individuals/3/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-029_75e19930c111	gomodel:ARGSUCCINSYN-RXN	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ARGSUCCINSYN-RXN RO:0002234 gomodel:CHEBI_456215_ARGSUCCINSYN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/28; endpoint types: /individuals/3/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-030_43cdc5b91c6f	gomodel:N-ACETYLGLUTPREDUCT-RXN	RO:0002234	CHEBI:29123	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:N-ACETYLGLUTPREDUCT-RXN RO:0002234 gomodel:CHEBI_29123_N-ACETYLGLUTPREDUCT-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/29; endpoint types: /individuals/46/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-031_226f45c946da	gomodel:ACETYLORNTRANSAM-RXN	BFO:0000050	GO:0006526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ACETYLORNTRANSAM-RXN BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/30; endpoint types: /individuals/1/type; /individuals/135/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-032_102ab53f6a32	SGD:S000003607	pathwaymech:enables	gomodel:N-ACETYLTRANSFER-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40360|gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:N-ACETYLTRANSFER-RXN RO:0002333 gomodel:YJL071W-MONOMER_N-ACETYLTRANSFER-RXN_controller."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/31; endpoint types: /individuals/47/type; /individuals/54/type""}, {""reference_id"": ""UniProtKB:P40360"", ""source_assertion"": ""UniProtKB:P40360 annotates acetyl-CoA-dependent L-glutamate N-acetylation (RHEA:24292); this corrects the imported methionine-activity label."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/1707/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P40360"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40360 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-033_be483133756d	gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704	RO:0002234	CHEBI:44337	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704 RO:0002234 gomodel:CHEBI_44337_N-ACETYLTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/32; endpoint types: /individuals/136/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-036_38250af504eb	SGD:S000000871	pathwaymech:enables	gomodel:ACETYLGLUTKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ACETYLGLUTKIN-RXN RO:0002333 gomodel:YER069W-MONOMER_ACETYLGLUTKIN-RXN_controller."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/35; endpoint types: /individuals/0/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-037_ee5bb1ddf1a8	gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN	RO:0002234	CHEBI:44337	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_44337_GLUTAMATE-N-ACETYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/36; endpoint types: /individuals/45/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-038_c9c7478f217b	gomodel:ARGSUCCINSYN-RXN	RO:0002233	CHEBI:29991	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ARGSUCCINSYN-RXN RO:0002233 gomodel:CHEBI_29991_ARGSUCCINSYN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/37; endpoint types: /individuals/3/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-039_337138cc2c8c	gomodel:ACETYLORNTRANSAM-RXN	RO:0002233	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ACETYLORNTRANSAM-RXN RO:0002233 gomodel:CHEBI_29985_ACETYLORNTRANSAM-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/38; endpoint types: /individuals/1/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-040_679686a26be1	SGD:S000004666	pathwaymech:enables	gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN RO:0002333 gomodel:YMR062C-MONOMER_GLUTAMATE-N-ACETYLTRANSFERASE-RXN_controller."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/39; endpoint types: /individuals/45/type; /individuals/56/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-041_e3359b387e7b	SGD:S000004666	pathwaymech:enables	gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q04728|gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704 RO:0002333 gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000709."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/40; endpoint types: /individuals/136/type; /individuals/141/type""}, {""reference_id"": ""UniProtKB:Q04728"", ""source_assertion"": ""UniProtKB:Q04728 annotates acetyl-CoA-dependent L-glutamate N-acetylation (RHEA:24292); this corrects the imported methionine-activity label."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2639/comments/2/reaction""}]"	"[{""id"": ""UniProtKB:Q04728"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q04728 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-042_e21cd0fead9c	gomodel:ACETYLORNTRANSAM-RXN	RO:0002233	CHEBI:29123	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ACETYLORNTRANSAM-RXN RO:0002233 gomodel:CHEBI_29123_N-ACETYLGLUTPREDUCT-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/41; endpoint types: /individuals/1/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-043_bb916fe9271b	gomodel:ORNCARBAMTRANSFER-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ORNCARBAMTRANSFER-RXN RO:0002234 gomodel:CHEBI_15378_ORNCARBAMTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/42; endpoint types: /individuals/48/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-044_590f621f852f	gomodel:CARBPSYN-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002234 gomodel:CHEBI_456216_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/43; endpoint types: /individuals/4/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-045_372256374f06	gomodel:ACETYLGLUTKIN-RXN	RO:0002233	CHEBI:44337	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ACETYLGLUTKIN-RXN RO:0002233 gomodel:CHEBI_44337_N-ACETYLTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/44; endpoint types: /individuals/0/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-046_b3b7982ac8a3	gomodel:ORNCARBAMTRANSFER-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ORNCARBAMTRANSFER-RXN RO:0002234 gomodel:CHEBI_43474_ORNCARBAMTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/45; endpoint types: /individuals/48/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-047_fbe606cb2a93	gomodel:ACETYLORNTRANSAM-RXN	RO:0002234	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ACETYLORNTRANSAM-RXN RO:0002234 gomodel:CHEBI_16810_ACETYLORNTRANSAM-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/46; endpoint types: /individuals/1/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-048_80bdd00c3052	gomodel:N-ACETYLGLUTPREDUCT-RXN	RO:0002233	CHEBI:57936	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:N-ACETYLGLUTPREDUCT-RXN RO:0002233 gomodel:CHEBI_57936_ACETYLGLUTKIN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/47; endpoint types: /individuals/46/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-049_1a002bd7cdd9	gomodel:N-ACETYLTRANSFER-RXN	RO:0002234	CHEBI:44337	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:N-ACETYLTRANSFER-RXN RO:0002234 gomodel:CHEBI_44337_N-ACETYLTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/48; endpoint types: /individuals/47/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-051_945a044fa981	gomodel:CARBPSYN-RXN	RO:0002234	CHEBI:58228	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002234 gomodel:CHEBI_58228_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/50; endpoint types: /individuals/4/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-052_89a8c786a074	gomodel:N-ACETYLGLUTPREDUCT-RXN	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:N-ACETYLGLUTPREDUCT-RXN RO:0002233 gomodel:CHEBI_57783_N-ACETYLGLUTPREDUCT-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/51; endpoint types: /individuals/46/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-053_bbdace3b1551	gomodel:CARBPSYN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002233 gomodel:CHEBI_30616_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/52; endpoint types: /individuals/4/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-054_c250f43a3a95	gomodel:CARBPSYN-RXN	RO:0002234	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002234 gomodel:CHEBI_29985_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/53; endpoint types: /individuals/4/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-055_2d5bd760b507	gomodel:ARGSUCCINLYA-RXN	RO:0002234	CHEBI:29806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ARGSUCCINLYA-RXN RO:0002234 gomodel:CHEBI_29806_ARGSUCCINLYA-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/54; endpoint types: /individuals/2/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-058_33d4b7f59476	gomodel:N-ACETYLGLUTPREDUCT-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:N-ACETYLGLUTPREDUCT-RXN RO:0002233 gomodel:CHEBI_15378_N-ACETYLGLUTPREDUCT-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/57; endpoint types: /individuals/46/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-059_f858635f282b	gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN	BFO:0000050	GO:0006526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/58; endpoint types: /individuals/45/type; /individuals/135/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-060_fb3eda26f181	gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704 RO:0002234 gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000707."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/59; endpoint types: /individuals/136/type; /individuals/139/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-061_e1cf07dafa1e	gomodel:ARGSUCCINSYN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ARGSUCCINSYN-RXN RO:0002233 gomodel:CHEBI_30616_ARGSUCCINSYN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/60; endpoint types: /individuals/3/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-062_bdd446adb6fe	gomodel:CARBPSYN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN BFO:0000066 gomodel:reaction_CARBPSYN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/61; endpoint types: /individuals/4/type; /individuals/130/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-063_dc647db4e420	gomodel:N-ACETYLTRANSFER-RXN	RO:0002233	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:N-ACETYLTRANSFER-RXN RO:0002233 gomodel:CHEBI_29985_N-ACETYLTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/62; endpoint types: /individuals/47/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-064_8dec0c720790	gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN	RO:0002234	CHEBI:46911	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:GLUTAMATE-N-ACETYLTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_46911_GLUTAMATE-N-ACETYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/63; endpoint types: /individuals/45/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-065_439560664996	gomodel:ACETYLGLUTKIN-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ACETYLGLUTKIN-RXN RO:0002234 gomodel:CHEBI_456216_ACETYLGLUTKIN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/64; endpoint types: /individuals/0/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-066_60bf47e07a88	gomodel:ARGSUCCINLYA-RXN	BFO:0000050	GO:0006526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ARGSUCCINLYA-RXN BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/65; endpoint types: /individuals/2/type; /individuals/135/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-067_abda7db4a784	SGD:S000001060	pathwaymech:enables	gomodel:ARGSUCCINLYA-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ARGSUCCINLYA-RXN RO:0002333 gomodel:YHR018C-MONOMER_ARGSUCCINLYA-RXN_controller."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/66; endpoint types: /individuals/2/type; /individuals/53/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-068_fe8a2cafbb78	gomodel:ARGSUCCINLYA-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ARGSUCCINLYA-RXN BFO:0000066 gomodel:reaction_ARGSUCCINLYA-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/67; endpoint types: /individuals/2/type; /individuals/128/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-069_5bfaef7f067f	gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704	BFO:0000050	GO:0006526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704 BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/68; endpoint types: /individuals/136/type; /individuals/135/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-070_bdefb34c4e95	gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704	RO:0002233	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704 RO:0002233 gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000706."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/69; endpoint types: /individuals/136/type; /individuals/138/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-071_0846fd3f4b82	SGD:S000005419	pathwaymech:enables	gomodel:ARGSUCCINSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ARGSUCCINSYN-RXN RO:0002333 gomodel:YOL058W-MONOMER_ARGSUCCINSYN-RXN_controller."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/70; endpoint types: /individuals/3/type; /individuals/57/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-072_afd47f13813e	gomodel:N-ACETYLTRANSFER-RXN	BFO:0000050	GO:0006526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:N-ACETYLTRANSFER-RXN BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/71; endpoint types: /individuals/47/type; /individuals/135/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-073_178ec0434919	gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704	RO:0002233	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000704 RO:0002233 gomodel:YeastPathways_ARGSYNBSUB-PWY/6a4c244800000705."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/72; endpoint types: /individuals/136/type; /individuals/137/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-074_4b8ff3d18243	gomodel:ARGSUCCINSYN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ARGSUCCINSYN-RXN BFO:0000066 gomodel:reaction_ARGSUCCINSYN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/73; endpoint types: /individuals/3/type; /individuals/129/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-075_9bb3002e6ca4	SGD:S000217863	pathwaymech:enables	gomodel:CARBPSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002333 gomodel:CPLX3O-887_CARBPSYN-RXN_controller."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/74; endpoint types: /individuals/4/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-076_39077b54ea1c	gomodel:ACETYLGLUTKIN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ACETYLGLUTKIN-RXN RO:0002233 gomodel:CHEBI_30616_ACETYLGLUTKIN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/75; endpoint types: /individuals/0/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-077_f60d540244d9	gomodel:N-ACETYLGLUTPREDUCT-RXN	BFO:0000050	GO:0006526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:N-ACETYLGLUTPREDUCT-RXN BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/76; endpoint types: /individuals/46/type; /individuals/135/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-078_7f91a1cea663	SGD:S000005500	pathwaymech:enables	gomodel:ACETYLORNTRANSAM-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ACETYLORNTRANSAM-RXN RO:0002333 gomodel:YOL140W-MONOMER_ACETYLORNTRANSAM-RXN_controller."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/77; endpoint types: /individuals/1/type; /individuals/58/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-079_7a4ac6715376	SGD:S000217863	BFO:0000051	SGD:S000005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:CPLX3O-887_CARBPSYN-RXN_controller BFO:0000051 gomodel:SGD_S000005829_CPLX3O-887_component."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/78; endpoint types: /individuals/44/type; /individuals/50/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-080_21595fe7599f	gomodel:CARBPSYN-RXN	BFO:0000050	GO:0006526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/79; endpoint types: /individuals/4/type; /individuals/135/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-081_7cc3f596e877	gomodel:CARBPSYN-RXN	RO:0002233	CHEBI:17544	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:CARBPSYN-RXN RO:0002233 gomodel:CHEBI_17544_CARBPSYN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/80; endpoint types: /individuals/4/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-082_a14ab154cf57	gomodel:ARGSUCCINSYN-RXN	RO:0002234	CHEBI:57472	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ARGSUCCINSYN-RXN RO:0002234 gomodel:CHEBI_57472_ARGSUCCINSYN-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/81; endpoint types: /individuals/3/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-083_cc01827d6ecd	gomodel:ARGSUCCINSYN-RXN	BFO:0000050	GO:0006526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ARGSUCCINSYN-RXN BFO:0000050 gomodel:YeastPathways_ARGSYNBSUB-PWY/YeastPathways_ARGSYNBSUB-PWY."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/82; endpoint types: /individuals/3/type; /individuals/135/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-084_77a953ac1206	gomodel:N-ACETYLTRANSFER-RXN	RO:0002233	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:N-ACETYLTRANSFER-RXN RO:0002233 gomodel:CHEBI_57288_N-ACETYLTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/83; endpoint types: /individuals/47/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_edge-085_df316b0e58d2	gomodel:ORNCARBAMTRANSFER-RXN	RO:0002234	CHEBI:57743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSYNBSUB-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_assertion"": ""The model asserts gomodel:ORNCARBAMTRANSFER-RXN RO:0002234 gomodel:CHEBI_57743_ORNCARBAMTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_ARGSYNBSUB-PWY.json#/facts/84; endpoint types: /individuals/48/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSYNBSUB-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_ARGSYNBSUB-PWY.json"", ""title"": ""GO-CAM L-arginine biosynthesis II acetyl cycle model YeastPathways_ARGSYNBSUB-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_complex-1dcec51f57f8_7912290a7ece	SGD:S000217863	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000217863	Complex location from the independent composition source; original GO-CAM activity locations are retained with their own provenance.	"[{""reference_id"": ""SGD:S000217863"", ""source_assertion"": ""Complex Portal CPX-579 records cellular location GO:0005737 (cytoplasm); its evidence classification is ECO:0000353: physical interaction evidence."", ""source_locator"": ""Complex Portal JSON #/crossReferences/9; /evidenceType""}]"	"[{""id"": ""SGD:S000217863"", ""source_sha256"": ""ccbb1369177abe4083a66a31055b2e69ff26d38506e4c8a7e063ed786a2194cc"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-579: Carbamoyl-phosphate synthase arginine-specific"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-579""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_location-77e173e27741_8f39acb18867	SGD:S000003624	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05150	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P05150"", ""source_assertion"": ""UniProtKB:P05150 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/100/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P05150"", ""source_assertion"": ""UniProtKB:P05150 has the exact SGD cross-reference SGD:S000003624."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/100/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P05150"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P05150 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_location-10342e417b5d_f19840e3f09b	SGD:S000003870	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P03965	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:200419); ECO:0000269 (PubMed:205532)	"[{""reference_id"": ""UniProtKB:P03965"", ""source_assertion"": ""UniProtKB:P03965 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/75/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P03965"", ""source_assertion"": ""UniProtKB:P03965 has the exact SGD cross-reference SGD:S000003870."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/75/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P03965"", ""source_sha256"": ""2ad9b6d84d565238960a053870fa90a6033bc212bbe1a4c9923fd55d7e7d7fc1"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P03965 SGD cross-reference"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_location-b98406cdafcc_705efdee72e9	SGD:S000000871	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q01217	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:Q01217"", ""source_assertion"": ""UniProtKB:Q01217 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2384/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q01217"", ""source_assertion"": ""UniProtKB:Q01217 has the exact SGD cross-reference SGD:S000000871."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2384/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q01217"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q01217 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_location-98a7388ece3d_babe20d194e9	SGD:S000003607	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40360	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:205532)	"[{""reference_id"": ""UniProtKB:P40360"", ""source_assertion"": ""UniProtKB:P40360 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1707/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P40360"", ""source_assertion"": ""UniProtKB:P40360 has the exact SGD cross-reference SGD:S000003607."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1707/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40360"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40360 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_location-e323a6c2d848_cd078bf472ab	SGD:S000004666	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q04728	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03124); ECO:0000269 (PubMed:14576278)	"[{""reference_id"": ""UniProtKB:Q04728"", ""source_assertion"": ""UniProtKB:Q04728 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2639/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q04728"", ""source_assertion"": ""UniProtKB:Q04728 has the exact SGD cross-reference SGD:S000004666."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2639/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q04728"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q04728 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_location-e4f527a1b19e_725ab9eb534c	SGD:S000005419	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P22768	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:205532)	"[{""reference_id"": ""UniProtKB:P22768"", ""source_assertion"": ""UniProtKB:P22768 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/599/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P22768"", ""source_assertion"": ""UniProtKB:P22768 has the exact SGD cross-reference SGD:S000005419."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/599/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P22768"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P22768 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_location-6799aed56e2e_6b27c87023be	SGD:S000005500	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P18544	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:205532)	"[{""reference_id"": ""UniProtKB:P18544"", ""source_assertion"": ""UniProtKB:P18544 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3317/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P18544"", ""source_assertion"": ""UniProtKB:P18544 has the exact SGD cross-reference SGD:S000005500."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3317/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P18544"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P18544 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_location-e1da57d9d9b3_c5d2af931276	SGD:S000005829	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07258	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:200419); ECO:0000269 (PubMed:205532)	"[{""reference_id"": ""UniProtKB:P07258"", ""source_assertion"": ""UniProtKB:P07258 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/169/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07258"", ""source_assertion"": ""UniProtKB:P07258 has the exact SGD cross-reference SGD:S000005829."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/169/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07258"", ""source_sha256"": ""2ad9b6d84d565238960a053870fa90a6033bc212bbe1a4c9923fd55d7e7d7fc1"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07258 SGD cross-reference"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_cofactor-9da6898b0c4d_521b9abcca11	SGD:S000003870	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P03965	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (PROSITE-ProRule:PRU00409) Binds 4 Mg(2+) or Mn(2+) ions per subunit. UniProt note evidence: ECO:0000255 (PROSITE-ProRule:PRU00409)	"[{""reference_id"": ""UniProtKB:P03965"", ""source_assertion"": ""UniProtKB:P03965 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/75/comments/0/cofactors/0; /results/75/comments/0/note""}, {""reference_id"": ""UniProtKB:P03965"", ""source_assertion"": ""UniProtKB:P03965 has the exact SGD cross-reference SGD:S000003870."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/75/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P03965"", ""source_sha256"": ""2ad9b6d84d565238960a053870fa90a6033bc212bbe1a4c9923fd55d7e7d7fc1"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P03965 SGD cross-reference"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_cofactor-39cceffa6749_c4230e9562d3	SGD:S000003870	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P03965	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (PROSITE-ProRule:PRU00409) Binds 4 Mg(2+) or Mn(2+) ions per subunit. UniProt note evidence: ECO:0000255 (PROSITE-ProRule:PRU00409)	"[{""reference_id"": ""UniProtKB:P03965"", ""source_assertion"": ""UniProtKB:P03965 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/75/comments/0/cofactors/1; /results/75/comments/0/note""}, {""reference_id"": ""UniProtKB:P03965"", ""source_assertion"": ""UniProtKB:P03965 has the exact SGD cross-reference SGD:S000003870."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/75/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P03965"", ""source_sha256"": ""2ad9b6d84d565238960a053870fa90a6033bc212bbe1a4c9923fd55d7e7d7fc1"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P03965 SGD cross-reference"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSYNBSUB-PWY_cofactor-cd2c6b5c97a1_2d2bc34fdc70	SGD:S000005500	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P18544	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P18544"", ""source_assertion"": ""UniProtKB:P18544 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3317/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P18544"", ""source_assertion"": ""UniProtKB:P18544 has the exact SGD cross-reference SGD:S000005500."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3317/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P18544"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P18544 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-001_98d42314a54a	CHEBI:32682	pathwaymech:consumes	RHEA:15186	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15186		"[{""reference_id"": ""RHEA:15186"", ""source_assertion"": ""Rhea lists CHEBI:32682 on the substrates side of RHEA:15186 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15186']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15186"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-succinyl-L-arginine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15186""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-002_1f8909cb9266	CHEBI:57292	pathwaymech:consumes	RHEA:15186	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15186		"[{""reference_id"": ""RHEA:15186"", ""source_assertion"": ""Rhea lists CHEBI:57292 on the substrates side of RHEA:15186 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15186']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15186"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-succinyl-L-arginine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15186""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-003_0eb98b4ede8d	RHEA:15186	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15186		"[{""reference_id"": ""RHEA:15186"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:15186 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15186']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15186"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-succinyl-L-arginine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15186""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-004_2ae12910fbb2	RHEA:15186	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15186		"[{""reference_id"": ""RHEA:15186"", ""source_assertion"": ""Rhea lists CHEBI:57287 on the products side of RHEA:15186 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15186']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15186"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-succinyl-L-arginine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15186""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-005_a5e37ceb1a9e	RHEA:15186	pathwaymech:produces	CHEBI:58241	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15186		"[{""reference_id"": ""RHEA:15186"", ""source_assertion"": ""Rhea lists CHEBI:58241 on the products side of RHEA:15186 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15186']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15186"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-succinyl-L-arginine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15186""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-006_835959e7389d	CHEBI:15377	pathwaymech:consumes	RHEA:19534	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19534		"[{""reference_id"": ""RHEA:19534"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:19534 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19534']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19534"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-succinyl-L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19534""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-007_0728151f6da8	CHEBI:15378	pathwaymech:consumes	RHEA:19534	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19534		"[{""reference_id"": ""RHEA:19534"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:19534 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19534']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19534"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-succinyl-L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19534""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-008_56604479516d	CHEBI:58241	pathwaymech:consumes	RHEA:19534	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19534		"[{""reference_id"": ""RHEA:19534"", ""source_assertion"": ""Rhea lists CHEBI:58241 on the substrates side of RHEA:19534 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19534']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19534"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-succinyl-L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19534""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-009_2b9b5c0caf38	RHEA:19534	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19534		"[{""reference_id"": ""RHEA:19534"", ""source_assertion"": ""Rhea lists CHEBI:16526 on the products side of RHEA:19534 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19534']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19534"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-succinyl-L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19534""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-010_add791cb1d90	RHEA:19534	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19534		"[{""reference_id"": ""RHEA:19534"", ""source_assertion"": ""Rhea lists CHEBI:28938 on the products side of RHEA:19534 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19534']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19534"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-succinyl-L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19534""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-011_f4a71bbde058	RHEA:19534	pathwaymech:produces	CHEBI:58514	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19534		"[{""reference_id"": ""RHEA:19534"", ""source_assertion"": ""Rhea lists CHEBI:58514 on the products side of RHEA:19534 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19534']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19534"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-succinyl-L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/19534""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-012_2dec6564f038	CHEBI:16810	pathwaymech:consumes	RHEA:16954	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16954		"[{""reference_id"": ""RHEA:16954"", ""source_assertion"": ""Rhea lists CHEBI:16810 on the substrates side of RHEA:16954 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16954']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16954"", ""source_version"": ""139"", ""title"": ""Rhea N-succinyl-L-glutamate 5-semialdehyde-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16954""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-013_cdc8cb5ee336	CHEBI:58514	pathwaymech:consumes	RHEA:16954	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16954		"[{""reference_id"": ""RHEA:16954"", ""source_assertion"": ""Rhea lists CHEBI:58514 on the substrates side of RHEA:16954 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16954']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16954"", ""source_version"": ""139"", ""title"": ""Rhea N-succinyl-L-glutamate 5-semialdehyde-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16954""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-014_1b639db9d1c0	RHEA:16954	pathwaymech:produces	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16954		"[{""reference_id"": ""RHEA:16954"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the products side of RHEA:16954 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16954']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16954"", ""source_version"": ""139"", ""title"": ""Rhea N-succinyl-L-glutamate 5-semialdehyde-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16954""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-015_3e0d3b46e3fb	RHEA:16954	pathwaymech:produces	CHEBI:58520	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16954		"[{""reference_id"": ""RHEA:16954"", ""source_assertion"": ""Rhea lists CHEBI:58520 on the products side of RHEA:16954 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16954']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16954"", ""source_version"": ""139"", ""title"": ""Rhea N-succinyl-L-glutamate 5-semialdehyde-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16954""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-016_312316340e20	CHEBI:15377	pathwaymech:consumes	RHEA:10813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10813		"[{""reference_id"": ""RHEA:10813"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:10813 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10813']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10813"", ""source_version"": ""139"", ""title"": ""Rhea N-succinyl-L-glutamate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10813""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-017_941ce33ba5d9	CHEBI:57540	pathwaymech:consumes	RHEA:10813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10813		"[{""reference_id"": ""RHEA:10813"", ""source_assertion"": ""Rhea lists CHEBI:57540 on the substrates side of RHEA:10813 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10813']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10813"", ""source_version"": ""139"", ""title"": ""Rhea N-succinyl-L-glutamate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10813""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-018_bc64cc3d2635	CHEBI:58520	pathwaymech:consumes	RHEA:10813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10813		"[{""reference_id"": ""RHEA:10813"", ""source_assertion"": ""Rhea lists CHEBI:58520 on the substrates side of RHEA:10813 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10813']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10813"", ""source_version"": ""139"", ""title"": ""Rhea N-succinyl-L-glutamate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10813""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-019_02c4af62c2ff	RHEA:10813	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10813		"[{""reference_id"": ""RHEA:10813"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:10813 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10813']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10813"", ""source_version"": ""139"", ""title"": ""Rhea N-succinyl-L-glutamate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10813""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-020_5b53011807b6	RHEA:10813	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10813		"[{""reference_id"": ""RHEA:10813"", ""source_assertion"": ""Rhea lists CHEBI:57945 on the products side of RHEA:10813 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10813']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10813"", ""source_version"": ""139"", ""title"": ""Rhea N-succinyl-L-glutamate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10813""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-021_8659190a4b1f	RHEA:10813	pathwaymech:produces	CHEBI:58763	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10813		"[{""reference_id"": ""RHEA:10813"", ""source_assertion"": ""Rhea lists CHEBI:58763 on the products side of RHEA:10813 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10813']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10813"", ""source_version"": ""139"", ""title"": ""Rhea N-succinyl-L-glutamate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10813""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-022_dbfc6ec40aac	CHEBI:15377	pathwaymech:consumes	RHEA:15170	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15170		"[{""reference_id"": ""RHEA:15170"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:15170 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15170']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15170"", ""source_version"": ""139"", ""title"": ""Rhea L-glutamate- and succinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15170""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-023_d7f2660a6af0	CHEBI:58763	pathwaymech:consumes	RHEA:15170	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15170		"[{""reference_id"": ""RHEA:15170"", ""source_assertion"": ""Rhea lists CHEBI:58763 on the substrates side of RHEA:15170 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15170']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15170"", ""source_version"": ""139"", ""title"": ""Rhea L-glutamate- and succinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15170""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-024_6314b4c39396	RHEA:15170	pathwaymech:produces	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15170		"[{""reference_id"": ""RHEA:15170"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the products side of RHEA:15170 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15170']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15170"", ""source_version"": ""139"", ""title"": ""Rhea L-glutamate- and succinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15170""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-025_2403ebf68aae	RHEA:15170	pathwaymech:produces	CHEBI:30031	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15170		"[{""reference_id"": ""RHEA:15170"", ""source_assertion"": ""Rhea lists CHEBI:30031 on the products side of RHEA:15170 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15170']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15170"", ""source_version"": ""139"", ""title"": ""Rhea L-glutamate- and succinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15170""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-026_00f333a1ce84	EC:2.3.1.109	pathwaymech:catalyzes	RHEA:15186	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9393691|RHEA:15185		"[{""reference_id"": ""RHEA:15185"", ""source_assertion"": ""Rhea associates EC:2.3.1.109 with the reaction family containing RHEA:15186."", ""source_locator"": ""rh:ec""}, {""quote"": ""the aruF and aruG genes encode the subunits (AruAI and AruAII) of arginine and ornithine N2-succinyltransferases"", ""reference_id"": ""PMID:9393691"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Itoh, Journal of Bacteriology, 1997"", ""id"": ""PMID:9393691"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9393691/""}, {""id"": ""RHEA:15185"", ""source_version"": ""139"", ""title"": ""Rhea arginine N-succinyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/15185""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-027_ac64133c08db	EC:3.5.3.23	pathwaymech:catalyzes	RHEA:19534	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9393691|RHEA:19533		"[{""reference_id"": ""RHEA:19533"", ""source_assertion"": ""Rhea associates EC:3.5.3.23 with the reaction family containing RHEA:19534."", ""source_locator"": ""rh:ec""}, {""quote"": ""The aruR, aruC, aruD, aruB, and aruE genes specify the ArgR regulatory protein, N2-succinylornithine 5-aminotransferase, N-succinylglutamate 5-semialdehyde dehydrogenase, N2-succinylarginine dihydrolase, and N-succinylglutamate desuccinylase, respectively"", ""reference_id"": ""PMID:9393691"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Itoh, Journal of Bacteriology, 1997"", ""id"": ""PMID:9393691"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9393691/""}, {""id"": ""RHEA:19533"", ""source_version"": ""139"", ""title"": ""Rhea N-succinylarginine dihydrolase reaction"", ""url"": ""https://www.rhea-db.org/rhea/19533""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-028_94858966f787	EC:2.6.1.81	pathwaymech:catalyzes	RHEA:16954	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9393691|RHEA:16953		"[{""reference_id"": ""RHEA:16953"", ""source_assertion"": ""Rhea associates EC:2.6.1.81 with the reaction family containing RHEA:16954."", ""source_locator"": ""rh:ec""}, {""quote"": ""The aruR, aruC, aruD, aruB, and aruE genes specify the ArgR regulatory protein, N2-succinylornithine 5-aminotransferase, N-succinylglutamate 5-semialdehyde dehydrogenase, N2-succinylarginine dihydrolase, and N-succinylglutamate desuccinylase, respectively"", ""reference_id"": ""PMID:9393691"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Itoh, Journal of Bacteriology, 1997"", ""id"": ""PMID:9393691"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9393691/""}, {""id"": ""RHEA:16953"", ""source_version"": ""139"", ""title"": ""Rhea succinylornithine transaminase reaction"", ""url"": ""https://www.rhea-db.org/rhea/16953""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-029_081e44c076b7	EC:1.2.1.71	pathwaymech:catalyzes	RHEA:10813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9393691|RHEA:10812		"[{""reference_id"": ""RHEA:10812"", ""source_assertion"": ""Rhea associates EC:1.2.1.71 with the reaction family containing RHEA:10813."", ""source_locator"": ""rh:ec""}, {""quote"": ""The aruR, aruC, aruD, aruB, and aruE genes specify the ArgR regulatory protein, N2-succinylornithine 5-aminotransferase, N-succinylglutamate 5-semialdehyde dehydrogenase, N2-succinylarginine dihydrolase, and N-succinylglutamate desuccinylase, respectively"", ""reference_id"": ""PMID:9393691"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Itoh, Journal of Bacteriology, 1997"", ""id"": ""PMID:9393691"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9393691/""}, {""id"": ""RHEA:10812"", ""source_version"": ""139"", ""title"": ""Rhea succinylglutamate-semialdehyde dehydrogenase reaction"", ""url"": ""https://www.rhea-db.org/rhea/10812""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-030_68c13f765488	EC:3.5.1.96	pathwaymech:catalyzes	RHEA:15170	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9393691|RHEA:15169		"[{""reference_id"": ""RHEA:15169"", ""source_assertion"": ""Rhea associates EC:3.5.1.96 with the reaction family containing RHEA:15170."", ""source_locator"": ""rh:ec""}, {""quote"": ""The aruR, aruC, aruD, aruB, and aruE genes specify the ArgR regulatory protein, N2-succinylornithine 5-aminotransferase, N-succinylglutamate 5-semialdehyde dehydrogenase, N2-succinylarginine dihydrolase, and N-succinylglutamate desuccinylase, respectively"", ""reference_id"": ""PMID:9393691"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Itoh, Journal of Bacteriology, 1997"", ""id"": ""PMID:9393691"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9393691/""}, {""id"": ""RHEA:15169"", ""source_version"": ""139"", ""title"": ""Rhea succinylglutamate desuccinylase reaction"", ""url"": ""https://www.rhea-db.org/rhea/15169""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-031_00909ba3c5cf	RHEA:10813	pathwaymech:precedes	RHEA:15170	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:AST-PWY		"[{""reference_id"": ""MetaCyc:AST-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:10813 before RHEA:15170 in this pathway. Shared intermediate: CHEBI:58763."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:AST-PWY"", ""source_sha256"": ""d0411ebd7c6f42a12f82230b426a0f588c4025c7c0e2b3268be07acbb6b2d739"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arginine degradation II pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:AST-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-032_50f8d74b15af	RHEA:15186	pathwaymech:precedes	RHEA:19534	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:AST-PWY		"[{""reference_id"": ""MetaCyc:AST-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:15186 before RHEA:19534 in this pathway. Shared intermediate: CHEBI:58241."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:AST-PWY"", ""source_sha256"": ""d0411ebd7c6f42a12f82230b426a0f588c4025c7c0e2b3268be07acbb6b2d739"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arginine degradation II pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:AST-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-033_b33f339a87ee	RHEA:16954	pathwaymech:precedes	RHEA:10813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:AST-PWY		"[{""reference_id"": ""MetaCyc:AST-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:16954 before RHEA:10813 in this pathway. Shared intermediate: CHEBI:58520."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:AST-PWY"", ""source_sha256"": ""d0411ebd7c6f42a12f82230b426a0f588c4025c7c0e2b3268be07acbb6b2d739"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arginine degradation II pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:AST-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-034_fded2e3fe941	RHEA:19534	pathwaymech:precedes	RHEA:16954	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:AST-PWY		"[{""reference_id"": ""MetaCyc:AST-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:19534 before RHEA:16954 in this pathway. Shared intermediate: CHEBI:58514."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:AST-PWY"", ""source_sha256"": ""d0411ebd7c6f42a12f82230b426a0f588c4025c7c0e2b3268be07acbb6b2d739"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arginine degradation II pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:AST-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-035_ecd471d1a8bc	UniProtKB:O30508	pathwaymech:enables	RHEA:16954	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:O30508		"[{""reference_id"": ""UniProtKB:O30508"", ""source_assertion"": ""UniProt annotates UniProtKB:O30508 with catalytic activity for the reaction family of RHEA:16954. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:208964."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:O30508"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:O30508 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/O30508.json""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-036_87c80e1b3c71	UniProtKB:O30508	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:O30508		"[{""reference_id"": ""UniProtKB:O30508"", ""source_assertion"": ""UniProt locates UniProtKB:O30508 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:O30508"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:O30508 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/O30508.json""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-037_1bd742ecd2eb	UniProtKB:O30508	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:O30508		"[{""reference_id"": ""UniProtKB:O30508"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:O30508 (evidence: ECO:0000250). Binds 1 pyridoxal phosphate per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:O30508"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:O30508 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/O30508.json""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-038_9e2cb35b2243	UniProtKB:O50174	pathwaymech:enables	RHEA:10813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:O50174		"[{""reference_id"": ""UniProtKB:O50174"", ""source_assertion"": ""UniProt annotates UniProtKB:O50174 with catalytic activity for the reaction family of RHEA:10813. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:208964."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:O50174"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:O50174 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/O50174.json""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-039_143869e17581	UniProtKB:O50175	pathwaymech:enables	RHEA:19534	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:O50175		"[{""reference_id"": ""UniProtKB:O50175"", ""source_assertion"": ""UniProt annotates UniProtKB:O50175 with catalytic activity for the reaction family of RHEA:19534. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:208964."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:O50175"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:O50175 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/O50175.json""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-040_ddf46ecc4598	UniProtKB:O50177	pathwaymech:enables	RHEA:15170	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:O50177		"[{""reference_id"": ""UniProtKB:O50177"", ""source_assertion"": ""UniProt annotates UniProtKB:O50177 with catalytic activity for the reaction family of RHEA:15170. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:208964."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:O50177"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:O50177 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/O50177.json""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-041_d1f91a0675a2	UniProtKB:O50177	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:O50177		"[{""reference_id"": ""UniProtKB:O50177"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:O50177 (evidence: ECO:0000255). Binds 1 zinc ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:O50177"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:O50177 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/O50177.json""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-042_2fc9a4f68e93	UniProtKB:P80357	pathwaymech:enables	RHEA:15186	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P80357		"[{""reference_id"": ""UniProtKB:P80357"", ""source_assertion"": ""UniProt annotates UniProtKB:P80357 with catalytic activity for the reaction family of RHEA:15186. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:208964."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P80357"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P80357 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P80357.json""}]"	""
pathwaymech:MetaCyc_AST-PWY_edge-043_c81a7c8d87af	UniProtKB:P80358	pathwaymech:enables	RHEA:15186	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P80358		"[{""reference_id"": ""UniProtKB:P80358"", ""source_assertion"": ""UniProt annotates UniProtKB:P80358 with catalytic activity for the reaction family of RHEA:15186. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:208964."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P80358"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P80358 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P80358.json""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-001_d20a71f45acc	CHEBI:15378	pathwaymech:consumes	RHEA:17642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17642		"[{""reference_id"": ""RHEA:17642"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:17642 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17642']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17642"", ""source_version"": ""139"", ""title"": ""Rhea L-arginine decarboxylase direction"", ""url"": ""https://www.rhea-db.org/rhea/17642""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-002_55ab56699dcc	CHEBI:32682	pathwaymech:consumes	RHEA:17642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17642		"[{""reference_id"": ""RHEA:17642"", ""source_assertion"": ""Rhea lists CHEBI:32682 on the substrates side of RHEA:17642 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17642']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17642"", ""source_version"": ""139"", ""title"": ""Rhea L-arginine decarboxylase direction"", ""url"": ""https://www.rhea-db.org/rhea/17642""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-003_61d332428595	RHEA:17642	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17642		"[{""reference_id"": ""RHEA:17642"", ""source_assertion"": ""Rhea lists CHEBI:16526 on the products side of RHEA:17642 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17642']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17642"", ""source_version"": ""139"", ""title"": ""Rhea L-arginine decarboxylase direction"", ""url"": ""https://www.rhea-db.org/rhea/17642""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-004_f0e86e40485a	RHEA:17642	pathwaymech:produces	CHEBI:58145	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17642		"[{""reference_id"": ""RHEA:17642"", ""source_assertion"": ""Rhea lists CHEBI:58145 on the products side of RHEA:17642 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17642']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17642"", ""source_version"": ""139"", ""title"": ""Rhea L-arginine decarboxylase direction"", ""url"": ""https://www.rhea-db.org/rhea/17642""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-005_0cac0196d3c5	CHEBI:15377	pathwaymech:consumes	RHEA:18038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18038		"[{""reference_id"": ""RHEA:18038"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:18038 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18038']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18038"", ""source_version"": ""139"", ""title"": ""Rhea agmatine deiminase direction"", ""url"": ""https://www.rhea-db.org/rhea/18038""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-006_4ef2c1fe7ddf	CHEBI:58145	pathwaymech:consumes	RHEA:18038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18038		"[{""reference_id"": ""RHEA:18038"", ""source_assertion"": ""Rhea lists CHEBI:58145 on the substrates side of RHEA:18038 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18038']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18038"", ""source_version"": ""139"", ""title"": ""Rhea agmatine deiminase direction"", ""url"": ""https://www.rhea-db.org/rhea/18038""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-007_e5e8753d5f70	RHEA:18038	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18038		"[{""reference_id"": ""RHEA:18038"", ""source_assertion"": ""Rhea lists CHEBI:28938 on the products side of RHEA:18038 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18038']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18038"", ""source_version"": ""139"", ""title"": ""Rhea agmatine deiminase direction"", ""url"": ""https://www.rhea-db.org/rhea/18038""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-008_0f101c0ea1a3	RHEA:18038	pathwaymech:produces	CHEBI:58318	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18038		"[{""reference_id"": ""RHEA:18038"", ""source_assertion"": ""Rhea lists CHEBI:58318 on the products side of RHEA:18038 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18038']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18038"", ""source_version"": ""139"", ""title"": ""Rhea agmatine deiminase direction"", ""url"": ""https://www.rhea-db.org/rhea/18038""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-009_aa68b0d51c6b	CHEBI:15377	pathwaymech:consumes	RHEA:22285	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22285		"[{""reference_id"": ""RHEA:22285"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:22285 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22285']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22285"", ""source_version"": ""139"", ""title"": ""Rhea N-carbamoylputrescine amidohydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/22285""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-010_7aa9c5d32579	CHEBI:15378	pathwaymech:consumes	RHEA:22285	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22285		"[{""reference_id"": ""RHEA:22285"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:22285 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22285']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22285"", ""source_version"": ""139"", ""title"": ""Rhea N-carbamoylputrescine amidohydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/22285""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-011_152d88a93537	CHEBI:58318	pathwaymech:consumes	RHEA:22285	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22285		"[{""reference_id"": ""RHEA:22285"", ""source_assertion"": ""Rhea lists CHEBI:58318 on the substrates side of RHEA:22285 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22285']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22285"", ""source_version"": ""139"", ""title"": ""Rhea N-carbamoylputrescine amidohydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/22285""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-012_62250462ecb4	RHEA:22285	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22285		"[{""reference_id"": ""RHEA:22285"", ""source_assertion"": ""Rhea lists CHEBI:16526 on the products side of RHEA:22285 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22285']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22285"", ""source_version"": ""139"", ""title"": ""Rhea N-carbamoylputrescine amidohydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/22285""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-013_9f7c876ed0cb	RHEA:22285	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22285		"[{""reference_id"": ""RHEA:22285"", ""source_assertion"": ""Rhea lists CHEBI:28938 on the products side of RHEA:22285 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22285']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22285"", ""source_version"": ""139"", ""title"": ""Rhea N-carbamoylputrescine amidohydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/22285""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-014_94e88dc99ab7	RHEA:22285	pathwaymech:produces	CHEBI:326268	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22285		"[{""reference_id"": ""RHEA:22285"", ""source_assertion"": ""Rhea lists CHEBI:326268 on the products side of RHEA:22285 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22285']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22285"", ""source_version"": ""139"", ""title"": ""Rhea N-carbamoylputrescine amidohydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/22285""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-015_5d4503c75d08	EC:4.1.1.19	pathwaymech:catalyzes	RHEA:17642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17641		"[{""reference_id"": ""RHEA:17641"", ""source_assertion"": ""Rhea associates EC:4.1.1.19 with the reaction family containing RHEA:17642."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:17641"", ""source_version"": ""139"", ""title"": ""RHEA:17641 authority record"", ""url"": ""https://www.rhea-db.org/rhea/17641""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-016_a02be323f970	EC:3.5.3.12	pathwaymech:catalyzes	RHEA:18038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12634339|RHEA:18037		"[{""reference_id"": ""RHEA:18037"", ""source_assertion"": ""Rhea associates EC:3.5.3.12 with the reaction family containing RHEA:18038."", ""source_locator"": ""rh:ec""}, {""quote"": ""agmatine deiminase (the aguA product) and N-carbamoylputrescine amidohydrolase (the aguB product)"", ""reference_id"": ""PMID:12634339"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Nakada and Itoh, Microbiology, 2003"", ""id"": ""PMID:12634339"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12634339/""}, {""id"": ""RHEA:18037"", ""source_version"": ""139"", ""title"": ""RHEA:18037 authority record"", ""url"": ""https://www.rhea-db.org/rhea/18037""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-017_bd2fd39a2898	EC:3.5.1.53	pathwaymech:catalyzes	RHEA:22285	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12634339|RHEA:22284		"[{""reference_id"": ""RHEA:22284"", ""source_assertion"": ""Rhea associates EC:3.5.1.53 with the reaction family containing RHEA:22285."", ""source_locator"": ""rh:ec""}, {""quote"": ""agmatine deiminase (the aguA product) and N-carbamoylputrescine amidohydrolase (the aguB product)"", ""reference_id"": ""PMID:12634339"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Nakada and Itoh, Microbiology, 2003"", ""id"": ""PMID:12634339"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12634339/""}, {""id"": ""RHEA:22284"", ""source_version"": ""139"", ""title"": ""RHEA:22284 authority record"", ""url"": ""https://www.rhea-db.org/rhea/22284""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-018_57fc7a573ffc	RHEA:17642	pathwaymech:precedes	RHEA:18038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARGDEG-III-PWY		"[{""reference_id"": ""MetaCyc:ARGDEG-III-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:17642 before RHEA:18038 in this pathway. Shared intermediate: CHEBI:58145."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARGDEG-III-PWY"", ""source_sha256"": ""eff045abf8ef195f4f83425ace364d76b1734a458207d96d3f43c6b777045abe"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arginine degradation IV pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARGDEG-III-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-019_2c3c1111c0a3	RHEA:18038	pathwaymech:precedes	RHEA:22285	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARGDEG-III-PWY		"[{""reference_id"": ""MetaCyc:ARGDEG-III-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:18038 before RHEA:22285 in this pathway. Shared intermediate: CHEBI:58318."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARGDEG-III-PWY"", ""source_sha256"": ""eff045abf8ef195f4f83425ace364d76b1734a458207d96d3f43c6b777045abe"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arginine degradation IV pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARGDEG-III-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-020_5ed949f2465b	UniProtKB:Q9HUX1	pathwaymech:enables	RHEA:17642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q9HUX1		"[{""reference_id"": ""UniProtKB:Q9HUX1"", ""source_assertion"": ""UniProt annotates UniProtKB:Q9HUX1 with catalytic activity for the reaction family of RHEA:17642. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:208964."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:Q9HUX1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:Q9HUX1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9HUX1.json""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-021_926935d945d6	UniProtKB:Q9HUX1	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q9HUX1		"[{""reference_id"": ""UniProtKB:Q9HUX1"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:Q9HUX1 (evidence: ECO:0000255). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:Q9HUX1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:Q9HUX1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9HUX1.json""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-022_ed7903e0ecb6	UniProtKB:Q9HUX1	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q9HUX1		"[{""reference_id"": ""UniProtKB:Q9HUX1"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:Q9HUX1 (evidence: ECO:0000255). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:Q9HUX1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:Q9HUX1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9HUX1.json""}]"	""
pathwaymech:MetaCyc_ARGDEG-III-PWY_edge-023_b1138c48faab	UniProtKB:Q9I6J9	pathwaymech:enables	RHEA:18038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q9I6J9		"[{""reference_id"": ""UniProtKB:Q9I6J9"", ""source_assertion"": ""UniProt annotates UniProtKB:Q9I6J9 with catalytic activity for the reaction family of RHEA:18038. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:208964."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:Q9I6J9"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:Q9I6J9 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9I6J9.json""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-001_43d030f23150	CHEBI:15377	pathwaymech:consumes	RHEA:19598	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19598		"[{""reference_id"": ""RHEA:19598"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:19598 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19598']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19598"", ""source_version"": ""139"", ""title"": ""Rhea L-arginine deiminase direction"", ""url"": ""https://www.rhea-db.org/rhea/19598""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-002_01b9635604c1	CHEBI:32682	pathwaymech:consumes	RHEA:19598	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19598		"[{""reference_id"": ""RHEA:19598"", ""source_assertion"": ""Rhea lists CHEBI:32682 on the substrates side of RHEA:19598 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19598']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19598"", ""source_version"": ""139"", ""title"": ""Rhea L-arginine deiminase direction"", ""url"": ""https://www.rhea-db.org/rhea/19598""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-003_34df36850a13	RHEA:19598	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19598		"[{""reference_id"": ""RHEA:19598"", ""source_assertion"": ""Rhea lists CHEBI:28938 on the products side of RHEA:19598 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19598']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19598"", ""source_version"": ""139"", ""title"": ""Rhea L-arginine deiminase direction"", ""url"": ""https://www.rhea-db.org/rhea/19598""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-004_02ad15345174	RHEA:19598	pathwaymech:produces	CHEBI:57743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19598		"[{""reference_id"": ""RHEA:19598"", ""source_assertion"": ""Rhea lists CHEBI:57743 on the products side of RHEA:19598 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19598']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19598"", ""source_version"": ""139"", ""title"": ""Rhea L-arginine deiminase direction"", ""url"": ""https://www.rhea-db.org/rhea/19598""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-005_d0c4be9c08b1	CHEBI:15378	pathwaymech:consumes	RHEA:19515	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19515		"[{""reference_id"": ""RHEA:19515"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:19515 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19515']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19515"", ""source_version"": ""139"", ""title"": ""Rhea catabolic ornithine carbamoyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/19515""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-006_91865c954a51	CHEBI:43474	pathwaymech:consumes	RHEA:19515	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19515		"[{""reference_id"": ""RHEA:19515"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the substrates side of RHEA:19515 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19515']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19515"", ""source_version"": ""139"", ""title"": ""Rhea catabolic ornithine carbamoyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/19515""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-007_527f3db8d203	CHEBI:57743	pathwaymech:consumes	RHEA:19515	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19515		"[{""reference_id"": ""RHEA:19515"", ""source_assertion"": ""Rhea lists CHEBI:57743 on the substrates side of RHEA:19515 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19515']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19515"", ""source_version"": ""139"", ""title"": ""Rhea catabolic ornithine carbamoyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/19515""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-008_df3236e8362f	RHEA:19515	pathwaymech:produces	CHEBI:46911	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19515		"[{""reference_id"": ""RHEA:19515"", ""source_assertion"": ""Rhea lists CHEBI:46911 on the products side of RHEA:19515 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19515']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19515"", ""source_version"": ""139"", ""title"": ""Rhea catabolic ornithine carbamoyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/19515""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-009_540558e80666	RHEA:19515	pathwaymech:produces	CHEBI:58228	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19515		"[{""reference_id"": ""RHEA:19515"", ""source_assertion"": ""Rhea lists CHEBI:58228 on the products side of RHEA:19515 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19515']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19515"", ""source_version"": ""139"", ""title"": ""Rhea catabolic ornithine carbamoyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/19515""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-010_8ca41a9f44be	CHEBI:456216	pathwaymech:consumes	RHEA:30757	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30757		"[{""reference_id"": ""RHEA:30757"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the substrates side of RHEA:30757 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30757']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:30757"", ""source_version"": ""139"", ""title"": ""RHEA:30757 authority record"", ""url"": ""https://www.rhea-db.org/rhea/30757""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-011_1a3715ca1963	CHEBI:58228	pathwaymech:consumes	RHEA:30757	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30757		"[{""reference_id"": ""RHEA:30757"", ""source_assertion"": ""Rhea lists CHEBI:58228 on the substrates side of RHEA:30757 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30757']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:30757"", ""source_version"": ""139"", ""title"": ""RHEA:30757 authority record"", ""url"": ""https://www.rhea-db.org/rhea/30757""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-012_3c47ef11fe7f	RHEA:30757	pathwaymech:produces	CHEBI:13941	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30757		"[{""reference_id"": ""RHEA:30757"", ""source_assertion"": ""Rhea lists CHEBI:13941 on the products side of RHEA:30757 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30757']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:30757"", ""source_version"": ""139"", ""title"": ""RHEA:30757 authority record"", ""url"": ""https://www.rhea-db.org/rhea/30757""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-013_2a128f420ff2	RHEA:30757	pathwaymech:produces	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30757		"[{""reference_id"": ""RHEA:30757"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the products side of RHEA:30757 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30757']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:30757"", ""source_version"": ""139"", ""title"": ""RHEA:30757 authority record"", ""url"": ""https://www.rhea-db.org/rhea/30757""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-014_3c536f66b273	CHEBI:13941	pathwaymech:consumes	RHEA:15650	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15650		"[{""reference_id"": ""RHEA:15650"", ""source_assertion"": ""Rhea lists CHEBI:13941 on the substrates side of RHEA:15650 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15650']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15650"", ""source_version"": ""139"", ""title"": ""RHEA:15650 authority record"", ""url"": ""https://www.rhea-db.org/rhea/15650""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-015_a98c558bf745	CHEBI:15378	pathwaymech:consumes	RHEA:15650	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15650		"[{""reference_id"": ""RHEA:15650"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:15650 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15650']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15650"", ""source_version"": ""139"", ""title"": ""RHEA:15650 authority record"", ""url"": ""https://www.rhea-db.org/rhea/15650""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-016_806c93b3461e	RHEA:15650	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15650		"[{""reference_id"": ""RHEA:15650"", ""source_assertion"": ""Rhea lists CHEBI:16526 on the products side of RHEA:15650 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15650']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15650"", ""source_version"": ""139"", ""title"": ""RHEA:15650 authority record"", ""url"": ""https://www.rhea-db.org/rhea/15650""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-017_83d46165ba59	RHEA:15650	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15650		"[{""reference_id"": ""RHEA:15650"", ""source_assertion"": ""Rhea lists CHEBI:28938 on the products side of RHEA:15650 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15650']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15650"", ""source_version"": ""139"", ""title"": ""RHEA:15650 authority record"", ""url"": ""https://www.rhea-db.org/rhea/15650""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-018_766d8763df18	EC:3.5.3.6	pathwaymech:catalyzes	RHEA:19598	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:8759859|RHEA:19597		"[{""reference_id"": ""RHEA:19597"", ""source_assertion"": ""Rhea associates EC:3.5.3.6 with the reaction family containing RHEA:19598."", ""source_locator"": ""rh:ec""}, {""quote"": ""arcA gene coding for arginine deiminase"", ""reference_id"": ""PMID:8759859"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Ruepp and Soppa, Journal of Bacteriology, 1996"", ""id"": ""PMID:8759859"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/8759859/""}, {""id"": ""RHEA:19597"", ""source_version"": ""139"", ""title"": ""RHEA:19597 authority record"", ""url"": ""https://www.rhea-db.org/rhea/19597""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-019_262915ab0f81	EC:2.1.3.3	pathwaymech:catalyzes	RHEA:19515	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:8759859|RHEA:19513		"[{""reference_id"": ""RHEA:19513"", ""source_assertion"": ""Rhea associates EC:2.1.3.3 with the reaction family containing RHEA:19515."", ""source_locator"": ""rh:ec""}, {""quote"": ""catabolic ornithine transcarbamylase and the corresponding gene, arcB"", ""reference_id"": ""PMID:8759859"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Ruepp and Soppa, Journal of Bacteriology, 1996"", ""id"": ""PMID:8759859"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/8759859/""}, {""id"": ""RHEA:19513"", ""source_version"": ""139"", ""title"": ""RHEA:19513 authority record"", ""url"": ""https://www.rhea-db.org/rhea/19513""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-020_2fae080e1c4b	EC:2.7.2.2	pathwaymech:catalyzes	RHEA:30757	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARGDEGRAD-PWY|PMID:8759859		"[{""reference_id"": ""MetaCyc:ARGDEGRAD-PWY"", ""source_assertion"": ""The native pathway assigns EC:2.7.2.2 activity to the enzymatic step represented by RHEA:30757; this is a component step when the EC definition is an overall reaction."", ""source_locator"": ""Pathway/reaction-layout; Reaction/enzymatic-reaction and component-reaction relationships""}, {""quote"": ""arcC gene coding for carbamate kinase"", ""reference_id"": ""PMID:8759859"", ""source_locator"": ""PubMed Abstract""}]"	"[{""id"": ""MetaCyc:ARGDEGRAD-PWY"", ""source_sha256"": ""087603883767a16a4617bcfb2e3157ac9fbdd883d4b6c71583b2e0cbe0cba74f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arginine degradation V pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARGDEGRAD-PWY&detail=full""}, {""citation"": ""Ruepp and Soppa, Journal of Bacteriology, 1996"", ""id"": ""PMID:8759859"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/8759859/""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-021_cefcd69baee7	RHEA:19515	pathwaymech:precedes	RHEA:30757	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARGDEGRAD-PWY		"[{""reference_id"": ""MetaCyc:ARGDEGRAD-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:19515 before RHEA:30757 in this pathway. Shared intermediate: CHEBI:58228."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARGDEGRAD-PWY"", ""source_sha256"": ""087603883767a16a4617bcfb2e3157ac9fbdd883d4b6c71583b2e0cbe0cba74f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arginine degradation V pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARGDEGRAD-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-022_71e56410d4ba	RHEA:19598	pathwaymech:precedes	RHEA:19515	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARGDEGRAD-PWY		"[{""reference_id"": ""MetaCyc:ARGDEGRAD-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:19598 before RHEA:19515 in this pathway. Shared intermediate: CHEBI:57743."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARGDEGRAD-PWY"", ""source_sha256"": ""087603883767a16a4617bcfb2e3157ac9fbdd883d4b6c71583b2e0cbe0cba74f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arginine degradation V pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARGDEGRAD-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-023_69c535f64207	RHEA:30757	pathwaymech:precedes	RHEA:15650	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ARGDEGRAD-PWY		"[{""reference_id"": ""MetaCyc:ARGDEGRAD-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:30757 before RHEA:15650 in this pathway. Shared intermediate: CHEBI:13941."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ARGDEGRAD-PWY"", ""source_sha256"": ""087603883767a16a4617bcfb2e3157ac9fbdd883d4b6c71583b2e0cbe0cba74f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-arginine degradation V pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ARGDEGRAD-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-024_3fcefc517e3e	UniProtKB:Q48295	pathwaymech:enables	RHEA:30757	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q48295		"[{""reference_id"": ""UniProtKB:Q48295"", ""source_assertion"": ""UniProt annotates UniProtKB:Q48295 with catalytic activity for the overall reaction containing the native MetaCyc enzymatic component RHEA:30757. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:64091."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:Q48295"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:Q48295 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q48295.json""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-025_eae409dd20f1	UniProtKB:Q48295	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q48295		"[{""reference_id"": ""UniProtKB:Q48295"", ""source_assertion"": ""UniProt locates UniProtKB:Q48295 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:Q48295"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:Q48295 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q48295.json""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-026_b5a6a206503c	UniProtKB:Q48296	pathwaymech:enables	RHEA:19515	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q48296		"[{""reference_id"": ""UniProtKB:Q48296"", ""source_assertion"": ""UniProt annotates UniProtKB:Q48296 with catalytic activity for the reaction family of RHEA:19515. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:64091."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:Q48296"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:Q48296 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q48296.json""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-027_b0dfa30c5c79	CHEBI:32682	pathwaymech:activates	UniProtKB:Q48296	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q48296		"[{""reference_id"": ""UniProtKB:Q48296"", ""source_assertion"": ""UniProt activity-regulation annotation: Arginine lead to a slight activation. Inhibited by all nucleotide phosphates"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:Q48296"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:Q48296 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q48296.json""}]"	""
pathwaymech:MetaCyc_ARGDEGRAD-PWY_edge-028_a2a1939c55a3	UniProtKB:Q48296	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q48296		"[{""reference_id"": ""UniProtKB:Q48296"", ""source_assertion"": ""UniProt locates UniProtKB:Q48296 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:Q48296"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:Q48296 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q48296.json""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-001_a6f0f8b01c37	gomodel:ASNSYNB-RXN	RO:0002233	CHEBI:58359	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASNSYNB-RXN RO:0002233 gomodel:CHEBI_58359_ASNSYNB-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/0; endpoint types: /individuals/0/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-002_d9568a3db4bc	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003553	RO:0002413	gomodel:ASNSYNB-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003553 RO:0002413 gomodel:ASNSYNB-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/1; endpoint types: /individuals/37/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-003_55cd3760d780	gomodel:ASNSYNB-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASNSYNB-RXN RO:0002234 gomodel:CHEBI_29888_ASNSYNB-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/2; endpoint types: /individuals/0/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-004_1804530b4ffb	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568 RO:0002234 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003574."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/3; endpoint types: /individuals/51/type; /individuals/57/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-005_3aeeb7c6a40c	gomodel:ASNSYNB-RXN	RO:0002234	CHEBI:58048	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASNSYNB-RXN RO:0002234 gomodel:CHEBI_58048_ASNSYNB-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/4; endpoint types: /individuals/0/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-006_80203a374c45	gomodel:ASPAMINOTRANS-RXN	RO:0002234	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002234 gomodel:CHEBI_16810_ASPAMINOTRANS-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/5; endpoint types: /individuals/1/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-007_ed4d66dcc128	gomodel:ASPAMINOTRANS-RXN	RO:0002413	gomodel:ASNSYNB-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002413 gomodel:ASNSYNB-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/6; endpoint types: /individuals/1/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-008_1f1eb1fc1de7	gomodel:ASPAMINOTRANS-RXN	RO:0002233	CHEBI:16452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002233 gomodel:CHEBI_16452_ASPAMINOTRANS-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/7; endpoint types: /individuals/1/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-009_4ed2aecf497d	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568	RO:0002234	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568 RO:0002234 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003575."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/8; endpoint types: /individuals/51/type; /individuals/58/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-010_970e29b1d5ea	gomodel:ASPAMINOTRANS-RXN	RO:0002413	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002413 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/9; endpoint types: /individuals/1/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-011_351d6f46423f	gomodel:ASNSYNB-RXN	BFO:0000050	GO:0070981	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASNSYNB-RXN BFO:0000050 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/YeastPathways_ASPARAGINE-BIOSYNTHESIS-1."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/10; endpoint types: /individuals/0/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-012_32d28c357e66	gomodel:ASNSYNB-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASNSYNB-RXN RO:0002234 gomodel:CHEBI_15378_ASNSYNB-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/11; endpoint types: /individuals/0/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-013_cd94e743f2bc	gomodel:ASNSYNB-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASNSYNB-RXN RO:0002233 gomodel:CHEBI_30616_ASNSYNB-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/12; endpoint types: /individuals/0/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-014_8adcc5718989	SGD:S000006349	pathwaymech:enables	gomodel:ASNSYNB-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASNSYNB-RXN RO:0002333 gomodel:YPR145W-MONOMER_ASNSYNB-RXN_controller."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/13; endpoint types: /individuals/0/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-016_f2403770538c	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568	BFO:0000050	GO:0070981	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568 BFO:0000050 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/YeastPathways_ASPARAGINE-BIOSYNTHESIS-1."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/15; endpoint types: /individuals/51/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-017_978e80861dd1	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003553	RO:0002233	CHEBI:16452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003553 RO:0002233 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003555."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/16; endpoint types: /individuals/37/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-018_f5a252221ac0	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003553	RO:0002233	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003553 RO:0002233 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003554."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/17; endpoint types: /individuals/37/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-019_52ff7b4fcddf	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003553	RO:0002234	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003553 RO:0002234 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003556."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/18; endpoint types: /individuals/37/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-020_613ee66b0d7d	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568 RO:0002234 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003572."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/19; endpoint types: /individuals/51/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-021_ba37f8ac6c6f	gomodel:ASNSYNB-RXN	RO:0002234	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASNSYNB-RXN RO:0002234 gomodel:CHEBI_29985_ASNSYNB-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/20; endpoint types: /individuals/0/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-022_eaa5f6866be8	SGD:S000001589	pathwaymech:enables	gomodel:ASPAMINOTRANS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002333 gomodel:YKL106W-MONOMER_ASPAMINOTRANS-RXN_controller."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/21; endpoint types: /individuals/1/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-023_8e77a1fe2764	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568	RO:0002233	CHEBI:58359	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568 RO:0002233 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003569."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/22; endpoint types: /individuals/51/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-024_f9df6deaf1df	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003553	BFO:0000050	GO:0070981	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003553 BFO:0000050 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/YeastPathways_ASPARAGINE-BIOSYNTHESIS-1."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/23; endpoint types: /individuals/37/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-025_80e6692b3e41	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568 RO:0002233 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003570."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/24; endpoint types: /individuals/51/type; /individuals/53/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-026_4291afedab4e	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568 BFO:0000066 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003579."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/25; endpoint types: /individuals/51/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-027_96cb4c5ea3dc	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568 RO:0002233 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003571."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/26; endpoint types: /individuals/51/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-028_13a00fe1b4c8	gomodel:ASPAMINOTRANS-RXN	BFO:0000050	GO:0070981	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN BFO:0000050 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/YeastPathways_ASPARAGINE-BIOSYNTHESIS-1."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/27; endpoint types: /individuals/1/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-029_d4d2833642d5	gomodel:ASPAMINOTRANS-RXN	RO:0002233	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002233 gomodel:CHEBI_29985_ASPAMINOTRANS-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/28; endpoint types: /individuals/1/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-030_3af7bafdf5ee	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003553	RO:0002234	CHEBI:29991	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003553 RO:0002234 gomodel:CHEBI_29991_ASPAMINOTRANS-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/29; endpoint types: /individuals/37/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-031_1f5cc232eb85	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568	RO:0002234	CHEBI:58048	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568 RO:0002234 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003573."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/30; endpoint types: /individuals/51/type; /individuals/56/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-032_7c2d6692356f	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568	RO:0002233	CHEBI:29991	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568 RO:0002233 gomodel:CHEBI_29991_ASPAMINOTRANS-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/31; endpoint types: /individuals/51/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-033_cf817fa75fc0	gomodel:ASNSYNB-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASNSYNB-RXN RO:0002233 gomodel:CHEBI_15377_ASNSYNB-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/32; endpoint types: /individuals/0/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-034_a3e5cfe98d9e	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568 RO:0002234 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003576."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/33; endpoint types: /individuals/51/type; /individuals/59/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-035_c39fea82c4e8	SGD:S000004017	pathwaymech:enables	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003553	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003553 RO:0002333 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003557."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/34; endpoint types: /individuals/37/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-036_b4d30b91b159	gomodel:ASNSYNB-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASNSYNB-RXN BFO:0000066 gomodel:reaction_ASNSYNB-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/35; endpoint types: /individuals/0/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-037_af5d18b09177	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003553	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003553 BFO:0000066 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003559."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/36; endpoint types: /individuals/37/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-038_bb0384cfa5e6	SGD:S000003356	pathwaymech:enables	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568 RO:0002333 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003578."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/37; endpoint types: /individuals/51/type; /individuals/60/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-039_f92fa746e528	gomodel:ASNSYNB-RXN	RO:0002233	CHEBI:29991	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASNSYNB-RXN RO:0002233 gomodel:CHEBI_29991_ASPAMINOTRANS-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/38; endpoint types: /individuals/0/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-040_5f644759796e	gomodel:ASNSYNB-RXN	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASNSYNB-RXN RO:0002234 gomodel:CHEBI_456215_ASNSYNB-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/39; endpoint types: /individuals/0/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-041_0381b5740fa4	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003553	RO:0002413	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003553 RO:0002413 gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1/6a4c244800003568."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/40; endpoint types: /individuals/37/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_edge-042_605a3d397cba	gomodel:ASPAMINOTRANS-RXN	RO:0002234	CHEBI:29991	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002234 gomodel:CHEBI_29991_ASPAMINOTRANS-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json#/facts/41; endpoint types: /individuals/1/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_ASPARAGINE-BIOSYNTHESIS-1.json"", ""title"": ""GO-CAM L-asparagine biosynthesis I model YeastPathways_ASPARAGINE-BIOSYNTHESIS-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_location-6e825fa767f7_de1d9db58b95	SGD:S000001589	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q01802	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:14576278)	"[{""reference_id"": ""UniProtKB:Q01802"", ""source_assertion"": ""UniProtKB:Q01802 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4042/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q01802"", ""source_assertion"": ""UniProtKB:Q01802 has the exact SGD cross-reference SGD:S000001589."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4042/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q01802"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q01802 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_location-1e7bf32ae78a_527b0a511c63	SGD:S000004017	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23542	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:9288922) Source qualification: Targeted to peroxisomes in cells grown in oleate	"[{""reference_id"": ""UniProtKB:P23542"", ""source_assertion"": ""UniProtKB:P23542 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/619/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P23542"", ""source_assertion"": ""UniProtKB:P23542 has the exact SGD cross-reference SGD:S000004017."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/619/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P23542"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P23542 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_location-6a637403e389_f1fe5ac5f814	SGD:S000004017	RO:0001025	GO:0005777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23542	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:9288922) Source qualification: Targeted to peroxisomes in cells grown in oleate	"[{""reference_id"": ""UniProtKB:P23542"", ""source_assertion"": ""UniProtKB:P23542 annotates location Peroxisome (SL-0204)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/619/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P23542"", ""source_assertion"": ""UniProtKB:P23542 has the exact SGD cross-reference SGD:S000004017."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/619/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P23542"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P23542 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_cofactor-8644f9391497_41da9af6ea71	SGD:S000001589	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q01802	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:Q01802"", ""source_assertion"": ""UniProtKB:Q01802 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4042/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:Q01802"", ""source_assertion"": ""UniProtKB:Q01802 has the exact SGD cross-reference SGD:S000001589."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4042/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q01802"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q01802 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-BIOSYNTHESIS-1_cofactor-decdaaabf93f_bd1090e22528	SGD:S000004017	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23542	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:6811576); ECO:0000269 (PubMed:9655342)	"[{""reference_id"": ""UniProtKB:P23542"", ""source_assertion"": ""UniProtKB:P23542 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/619/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P23542"", ""source_assertion"": ""UniProtKB:P23542 has the exact SGD cross-reference SGD:S000004017."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/619/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P23542"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P23542 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-001_f6ad664da098	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870	RO:0002234	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870 RO:0002234 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002873."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/0; endpoint types: /individuals/78/type; /individuals/81/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-002_237cd0783d2d	gomodel:ASPARAGHYD-RXN	RO:0002234	CHEBI:29991	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPARAGHYD-RXN RO:0002234 gomodel:CHEBI_29991_ASPARAGHYD-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/1; endpoint types: /individuals/1/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-003_67071a25b83c	gomodel:ASPAMINOTRANS-RXN	RO:0002233	CHEBI:29991	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002233 gomodel:CHEBI_29991_ASPARAGHYD-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/2; endpoint types: /individuals/0/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-004_56037d331f05	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808 BFO:0000066 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002814."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/3; endpoint types: /individuals/26/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-005_909bfa99bd03	SGD:S000002729	pathwaymech:enables	gomodel:ASPARAGHYD-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPARAGHYD-RXN RO:0002333 gomodel:YDR321W-MONOMER_ASPARAGHYD-RXN_controller."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/4; endpoint types: /individuals/1/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-006_83c3edaf17d8	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839	RO:0002234	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839 RO:0002234 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002842."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/5; endpoint types: /individuals/52/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-007_23e2e546a567	gomodel:ASPARAGHYD-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPARAGHYD-RXN RO:0002233 gomodel:CHEBI_15377_ASPARAGHYD-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/6; endpoint types: /individuals/1/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-008_034830fa9dd5	SGD:S000004017	pathwaymech:enables	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808 RO:0002333 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002813."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/7; endpoint types: /individuals/26/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-009_d76ef89098b6	gomodel:ASPAMINOTRANS-RXN	BFO:0000050	GO:0006530	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN BFO:0000050 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/YeastPathways_ASPARAGINE-DEG2-PWY."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/8; endpoint types: /individuals/0/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-010_b46be8691bec	gomodel:ASPARAGHYD-RXN	RO:0002234	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPARAGHYD-RXN RO:0002234 gomodel:CHEBI_28938_ASPARAGHYD-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/9; endpoint types: /individuals/1/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-011_4ad6eab10351	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839	BFO:0000050	GO:0006530	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839 BFO:0000050 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/YeastPathways_ASPARAGINE-DEG2-PWY."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/10; endpoint types: /individuals/52/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-012_ac2bfca828f0	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808	RO:0002234	CHEBI:16452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808 RO:0002234 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002811."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/11; endpoint types: /individuals/26/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-013_ba0ed80e691a	SGD:S000004147	pathwaymech:enables	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839 RO:0002333 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002844."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/12; endpoint types: /individuals/52/type; /individuals/56/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-014_be1a587bf6d6	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822	RO:0002234	CHEBI:29991	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822 RO:0002234 gomodel:CHEBI_29991_ASPARAGHYD-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/13; endpoint types: /individuals/39/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-015_e1453067c62c	SGD:S000004150	pathwaymech:enables	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855 RO:0002333 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002860."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/14; endpoint types: /individuals/65/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-016_d6a1d008bae3	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808	BFO:0000050	GO:0006530	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808 BFO:0000050 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/YeastPathways_ASPARAGINE-DEG2-PWY."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/15; endpoint types: /individuals/26/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-017_eaf4c336257a	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822	BFO:0000050	GO:0006530	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822 BFO:0000050 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/YeastPathways_ASPARAGINE-DEG2-PWY."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/16; endpoint types: /individuals/39/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-018_db7ab555bcf9	gomodel:ASPARAGHYD-RXN	RO:0002233	CHEBI:58048	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPARAGHYD-RXN RO:0002233 gomodel:CHEBI_58048_ASPARAGHYD-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/17; endpoint types: /individuals/1/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-019_1ccc65a84626	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870	BFO:0000050	GO:0006530	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870 BFO:0000050 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/YeastPathways_ASPARAGINE-DEG2-PWY."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/18; endpoint types: /individuals/78/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-020_472a857d7054	SGD:S000004148	pathwaymech:enables	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870 RO:0002333 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002875."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/19; endpoint types: /individuals/78/type; /individuals/82/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-021_1d650c9308d0	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822	RO:0002233	CHEBI:58048	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822 RO:0002233 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002824."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/20; endpoint types: /individuals/39/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-023_d2a02d00d3b1	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855 RO:0002233 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002856."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/22; endpoint types: /individuals/65/type; /individuals/66/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-025_e3e3c1ff332d	SGD:S000001589	pathwaymech:enables	gomodel:ASPAMINOTRANS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002333 gomodel:YKL106W-MONOMER_ASPAMINOTRANS-RXN_controller."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/24; endpoint types: /individuals/0/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-026_c5348904a669	gomodel:ASPAMINOTRANS-RXN	RO:0002234	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002234 gomodel:CHEBI_29985_ASPAMINOTRANS-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/25; endpoint types: /individuals/0/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-028_cbc76ef7c0a6	gomodel:ASPAMINOTRANS-RXN	RO:0002233	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002233 gomodel:CHEBI_16810_ASPAMINOTRANS-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/27; endpoint types: /individuals/0/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-030_142d4ed14f72	gomodel:ASPAMINOTRANS-RXN	RO:0002234	CHEBI:16452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPAMINOTRANS-RXN RO:0002234 gomodel:CHEBI_16452_ASPAMINOTRANS-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/29; endpoint types: /individuals/0/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-031_a9a5c5f3c31c	gomodel:ASPARAGHYD-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPARAGHYD-RXN BFO:0000066 gomodel:reaction_ASPARAGHYD-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/30; endpoint types: /individuals/1/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-032_1f5e130e81e3	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855	RO:0002233	CHEBI:58048	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855 RO:0002233 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002857."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/31; endpoint types: /individuals/65/type; /individuals/67/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-033_1191e7e5442b	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808	RO:0002233	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808 RO:0002233 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002809."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/32; endpoint types: /individuals/26/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-034_ad1a9ad7ec72	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839	RO:0002234	CHEBI:29991	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839 RO:0002234 gomodel:CHEBI_29991_ASPARAGHYD-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/33; endpoint types: /individuals/52/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-035_73bfb6ba6a64	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808	RO:0002233	CHEBI:29991	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808 RO:0002233 gomodel:CHEBI_29991_ASPARAGHYD-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/34; endpoint types: /individuals/26/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-036_a7b80bcca505	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870	RO:0002233	CHEBI:58048	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870 RO:0002233 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002872."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/35; endpoint types: /individuals/78/type; /individuals/80/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-037_f1ad61aa6781	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870	RO:0002234	CHEBI:29991	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870 RO:0002234 gomodel:CHEBI_29991_ASPARAGHYD-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/36; endpoint types: /individuals/78/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-038_9773d0ba5b31	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002870 RO:0002233 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002871."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/37; endpoint types: /individuals/78/type; /individuals/79/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-039_fe3ac0958325	SGD:S000004145	pathwaymech:enables	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822 RO:0002333 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002828."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/38; endpoint types: /individuals/39/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-040_2752acc5a3db	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808	RO:0002234	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002808 RO:0002234 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002810."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/39; endpoint types: /individuals/26/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-041_7edc318abc8b	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855	RO:0002234	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855 RO:0002234 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002858."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/40; endpoint types: /individuals/65/type; /individuals/68/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-042_4321664fcddb	gomodel:ASPARAGHYD-RXN	BFO:0000050	GO:0006530	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:ASPARAGHYD-RXN BFO:0000050 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/YeastPathways_ASPARAGINE-DEG2-PWY."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/41; endpoint types: /individuals/1/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-043_a6bf4be4f2c8	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839 RO:0002233 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002840."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/42; endpoint types: /individuals/52/type; /individuals/53/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-044_c1c76ed8f193	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822 RO:0002233 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002823."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/43; endpoint types: /individuals/39/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-045_94f1c03084a2	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839	RO:0002233	CHEBI:58048	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002839 RO:0002233 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002841."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/44; endpoint types: /individuals/52/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-046_a19851fbbf03	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822	RO:0002234	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002822 RO:0002234 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002825."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/45; endpoint types: /individuals/39/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-048_bbfc2457f92a	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855	BFO:0000050	GO:0006530	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855 BFO:0000050 gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/YeastPathways_ASPARAGINE-DEG2-PWY."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/47; endpoint types: /individuals/65/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_edge-049_92df999c5a8d	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855	RO:0002234	CHEBI:29991	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ASPARAGINE-DEG2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_ASPARAGINE-DEG2-PWY/6a4c244800002855 RO:0002234 gomodel:CHEBI_29991_ASPARAGHYD-RXN."", ""source_locator"": ""./YeastPathways_ASPARAGINE-DEG2-PWY.json#/facts/48; endpoint types: /individuals/65/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_ASPARAGINE-DEG2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_ASPARAGINE-DEG2-PWY.json"", ""title"": ""GO-CAM asparagine degradation model YeastPathways_ASPARAGINE-DEG2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_location-4d55bfd40ead_bbaaa6b31218	SGD:S000002729	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38986	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P38986"", ""source_assertion"": ""UniProtKB:P38986 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3660/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38986"", ""source_assertion"": ""UniProtKB:P38986 has the exact SGD cross-reference SGD:S000002729."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3660/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38986"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38986 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_location-1e7bf32ae78a_059152d5cc84	SGD:S000004017	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23542	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:9288922) Source qualification: Targeted to peroxisomes in cells grown in oleate	"[{""reference_id"": ""UniProtKB:P23542"", ""source_assertion"": ""UniProtKB:P23542 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/619/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P23542"", ""source_assertion"": ""UniProtKB:P23542 has the exact SGD cross-reference SGD:S000004017."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/619/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P23542"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P23542 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_location-6a637403e389_3d628ef12d8b	SGD:S000004017	RO:0001025	GO:0005777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23542	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:9288922) Source qualification: Targeted to peroxisomes in cells grown in oleate	"[{""reference_id"": ""UniProtKB:P23542"", ""source_assertion"": ""UniProtKB:P23542 annotates location Peroxisome (SL-0204)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/619/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P23542"", ""source_assertion"": ""UniProtKB:P23542 has the exact SGD cross-reference SGD:S000004017."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/619/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P23542"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P23542 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_location-f482c7928e6e_b58e8e14ffe1	SGD:S000004147	RO:0001025	GO:0005576	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0CX77	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P0CX77"", ""source_assertion"": ""UniProtKB:P0CX77 annotates location Secreted (SL-0243)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/288/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P0CX77"", ""source_assertion"": ""UniProtKB:P0CX77 has the exact SGD cross-reference SGD:S000004147."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/288/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P0CX77"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P0CX77 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_location-301a57677d8d_f6e59b74f9f5	SGD:S000004147	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0CX77	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P0CX77"", ""source_assertion"": ""UniProtKB:P0CX77 annotates location Periplasm (SL-0200)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/288/comments/0/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P0CX77"", ""source_assertion"": ""UniProtKB:P0CX77 has the exact SGD cross-reference SGD:S000004147."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/288/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P0CX77"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P0CX77 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_location-4032d119a95f_4230da1c38f0	SGD:S000004150	RO:0001025	GO:0005576	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0CX79	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P0CX79"", ""source_assertion"": ""UniProtKB:P0CX79 annotates location Secreted (SL-0243)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/290/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P0CX79"", ""source_assertion"": ""UniProtKB:P0CX79 has the exact SGD cross-reference SGD:S000004150."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/290/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P0CX79"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P0CX79 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_location-ab43c46389c3_33960693b0a6	SGD:S000004150	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0CX79	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P0CX79"", ""source_assertion"": ""UniProtKB:P0CX79 annotates location Periplasm (SL-0200)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/290/comments/0/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P0CX79"", ""source_assertion"": ""UniProtKB:P0CX79 has the exact SGD cross-reference SGD:S000004150."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/290/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P0CX79"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P0CX79 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_location-26bda696cb66_eb6a8f653a35	SGD:S000004148	RO:0001025	GO:0005576	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0CX78	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P0CX78"", ""source_assertion"": ""UniProtKB:P0CX78 annotates location Secreted (SL-0243)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/289/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P0CX78"", ""source_assertion"": ""UniProtKB:P0CX78 has the exact SGD cross-reference SGD:S000004148."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/289/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P0CX78"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P0CX78 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_location-bb57e11b6792_0d95ff7ff97f	SGD:S000004148	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0CX78	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P0CX78"", ""source_assertion"": ""UniProtKB:P0CX78 annotates location Periplasm (SL-0200)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/289/comments/0/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P0CX78"", ""source_assertion"": ""UniProtKB:P0CX78 has the exact SGD cross-reference SGD:S000004148."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/289/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P0CX78"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P0CX78 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_location-6e825fa767f7_d6324e5c5d11	SGD:S000001589	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q01802	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:14576278)	"[{""reference_id"": ""UniProtKB:Q01802"", ""source_assertion"": ""UniProtKB:Q01802 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4042/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q01802"", ""source_assertion"": ""UniProtKB:Q01802 has the exact SGD cross-reference SGD:S000001589."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4042/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q01802"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q01802 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_location-ac58c4141e51_36630043ce7d	SGD:S000004145	RO:0001025	GO:0005576	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0CZ17	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P0CZ17"", ""source_assertion"": ""UniProtKB:P0CZ17 annotates location Secreted (SL-0243)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/299/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P0CZ17"", ""source_assertion"": ""UniProtKB:P0CZ17 has the exact SGD cross-reference SGD:S000004145."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/299/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P0CZ17"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P0CZ17 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_location-ba207ac402c3_33d7e7966542	SGD:S000004145	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0CZ17	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P0CZ17"", ""source_assertion"": ""UniProtKB:P0CZ17 annotates location Periplasm (SL-0200)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/299/comments/0/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P0CZ17"", ""source_assertion"": ""UniProtKB:P0CZ17 has the exact SGD cross-reference SGD:S000004145."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/299/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P0CZ17"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P0CZ17 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_cofactor-decdaaabf93f_4110541319ec	SGD:S000004017	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23542	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:6811576); ECO:0000269 (PubMed:9655342)	"[{""reference_id"": ""UniProtKB:P23542"", ""source_assertion"": ""UniProtKB:P23542 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/619/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P23542"", ""source_assertion"": ""UniProtKB:P23542 has the exact SGD cross-reference SGD:S000004017."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/619/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P23542"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P23542 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_ASPARAGINE-DEG2-PWY_cofactor-8644f9391497_a71cf6912f09	SGD:S000001589	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q01802	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:Q01802"", ""source_assertion"": ""UniProtKB:Q01802 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4042/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:Q01802"", ""source_assertion"": ""UniProtKB:Q01802 has the exact SGD cross-reference SGD:S000001589."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4042/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q01802"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q01802 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-001_94c464623d90	CHEBI:16347	pathwaymech:consumes	RHEA:28515	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28515		"[{""reference_id"": ""RHEA:28515"", ""source_assertion"": ""Rhea places CHEBI:16347 on the substrates side of directed RHEA:28515, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28515\""]/rh:substrates; http://rdf.rhea-db.org/28514_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_28514_compound_4231/rh:compound -> http://rdf.rhea-db.org/Compound_4231/rh:chebi""}]"	"[{""id"": ""RHEA:28515"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28515 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-002_76728412924a	CHEBI:30616	pathwaymech:consumes	RHEA:28515	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28515		"[{""reference_id"": ""RHEA:28515"", ""source_assertion"": ""Rhea places CHEBI:30616 on the substrates side of directed RHEA:28515, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28515\""]/rh:substrates; http://rdf.rhea-db.org/28514_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_28514_compound_6372/rh:compound -> http://rdf.rhea-db.org/Compound_6372/rh:chebi""}]"	"[{""id"": ""RHEA:28515"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28515 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-003_4a31efac4b35	CHEBI:57287	pathwaymech:consumes	RHEA:28515	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28515		"[{""reference_id"": ""RHEA:28515"", ""source_assertion"": ""Rhea places CHEBI:57287 on the substrates side of directed RHEA:28515, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28515\""]/rh:substrates; http://rdf.rhea-db.org/28514_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_28514_compound_1264/rh:compound -> http://rdf.rhea-db.org/Compound_1264/rh:chebi""}]"	"[{""id"": ""RHEA:28515"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28515 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-004_9c192bdc8663	RHEA:28515	pathwaymech:produces	CHEBI:60932	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28515		"[{""reference_id"": ""RHEA:28515"", ""source_assertion"": ""Rhea places CHEBI:60932 on the products side of directed RHEA:28515, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28515\""]/rh:products; http://rdf.rhea-db.org/28514_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_28514_compound_6425/rh:compound -> http://rdf.rhea-db.org/Compound_6425/rh:chebi""}]"	"[{""id"": ""RHEA:28515"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28515 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-005_45e0de0b3955	RHEA:28515	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28515		"[{""reference_id"": ""RHEA:28515"", ""source_assertion"": ""Rhea places CHEBI:456215 on the products side of directed RHEA:28515, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28515\""]/rh:products; http://rdf.rhea-db.org/28514_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_28514_compound_2590/rh:compound -> http://rdf.rhea-db.org/Compound_2590/rh:chebi""}]"	"[{""id"": ""RHEA:28515"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28515 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-006_87e9c27d73c3	RHEA:28515	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28515		"[{""reference_id"": ""RHEA:28515"", ""source_assertion"": ""Rhea places CHEBI:33019 on the products side of directed RHEA:28515, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28515\""]/rh:products; http://rdf.rhea-db.org/28514_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_28514_compound_2106/rh:compound -> http://rdf.rhea-db.org/Compound_2106/rh:chebi""}]"	"[{""id"": ""RHEA:28515"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28515 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-007_7628e96bcecd	CHEBI:60932	pathwaymech:consumes	RHEA:28339	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28339		"[{""reference_id"": ""RHEA:28339"", ""source_assertion"": ""Rhea places CHEBI:60932 on the substrates side of directed RHEA:28339, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28339\""]/rh:substrates; http://rdf.rhea-db.org/28338_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_28338_compound_6425/rh:compound -> http://rdf.rhea-db.org/Compound_6425/rh:chebi""}]"	"[{""id"": ""RHEA:28339"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28339 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-008_5eb7484ce754	RHEA:28339	pathwaymech:produces	CHEBI:60933	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28339		"[{""reference_id"": ""RHEA:28339"", ""source_assertion"": ""Rhea places CHEBI:60933 on the products side of directed RHEA:28339, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28339\""]/rh:products; http://rdf.rhea-db.org/28338_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_28338_compound_6426/rh:compound -> http://rdf.rhea-db.org/Compound_6426/rh:chebi""}]"	"[{""id"": ""RHEA:28339"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28339 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-009_bed51d50265b	RHEA:28339	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28339		"[{""reference_id"": ""RHEA:28339"", ""source_assertion"": ""Rhea places CHEBI:15377 on the products side of directed RHEA:28339, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28339\""]/rh:products; http://rdf.rhea-db.org/28338_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_28338_compound_1283/rh:compound -> http://rdf.rhea-db.org/Compound_1283/rh:chebi""}]"	"[{""id"": ""RHEA:28339"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28339 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-010_393be5c27980	CHEBI:60933	pathwaymech:consumes	RHEA:51586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51586		"[{""reference_id"": ""RHEA:51586"", ""source_assertion"": ""Rhea places CHEBI:60933 on the substrates side of directed RHEA:51586, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/51586\""]/rh:substrates; http://rdf.rhea-db.org/51584_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_51584_compound_6426/rh:compound -> http://rdf.rhea-db.org/Compound_6426/rh:chebi""}]"	"[{""id"": ""RHEA:51586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 51586 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-011_a6a0525e89df	RHEA-COMP:10686	pathwaymech:consumes	RHEA:51586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51586|UniProtKB:P60584	This is a whole generic electron-transfer flavoprotein redox state, not free FAD/FADH2 and not an identified FixA/FixB complex. Coefficient 1 belongs to the Rhea reference equation.	"[{""reference_id"": ""RHEA:51586"", ""source_assertion"": ""Rhea places RHEA-COMP:10686 on the substrates side of directed RHEA:51586, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/51586\""]/rh:substrates; http://rdf.rhea-db.org/51584_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_51584_compound_10686/rh:compound -> http://rdf.rhea-db.org/Compound_10686/rh:id, rh:name, rdfs:subClassOf""}, {""reference_id"": ""UniProtKB:P60584"", ""source_assertion"": ""CaiA catalytic activity cross-references RHEA-COMP:10686 as a Rhea component of the electron-transfer flavoprotein reaction. The function annotation proposes, but does not establish, FixA/FixB as donor."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences; comments[0].texts[0] (FUNCTION)""}]"	"[{""id"": ""RHEA:51586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 51586 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P60584"", ""source_sha256"": ""fb7c50d1e1b6635a32d938f51f83938b983abbd935b8aacab9c1797ea723a164"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P60584, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60584.json""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-012_d962e67913f9	RHEA:51586	pathwaymech:produces	CHEBI:61513	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51586		"[{""reference_id"": ""RHEA:51586"", ""source_assertion"": ""Rhea places CHEBI:61513 on the products side of directed RHEA:51586, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/51586\""]/rh:products; http://rdf.rhea-db.org/51584_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_51584_compound_6459/rh:compound -> http://rdf.rhea-db.org/Compound_6459/rh:chebi""}]"	"[{""id"": ""RHEA:51586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 51586 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-013_a8ec103f0dc8	RHEA:51586	pathwaymech:produces	RHEA-COMP:10685	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51586|UniProtKB:P60584	This is a whole generic electron-transfer flavoprotein redox state, not free FAD/FADH2 and not an identified FixA/FixB complex. Coefficient 1 belongs to the Rhea reference equation.	"[{""reference_id"": ""RHEA:51586"", ""source_assertion"": ""Rhea places RHEA-COMP:10685 on the products side of directed RHEA:51586, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/51586\""]/rh:products; http://rdf.rhea-db.org/51584_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_51584_compound_10685/rh:compound -> http://rdf.rhea-db.org/Compound_10685/rh:id, rh:name, rdfs:subClassOf""}, {""reference_id"": ""UniProtKB:P60584"", ""source_assertion"": ""CaiA catalytic activity cross-references RHEA-COMP:10685 as a Rhea component of the electron-transfer flavoprotein reaction. The function annotation proposes, but does not establish, FixA/FixB as donor."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences; comments[0].texts[0] (FUNCTION)""}]"	"[{""id"": ""RHEA:51586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 51586 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P60584"", ""source_sha256"": ""fb7c50d1e1b6635a32d938f51f83938b983abbd935b8aacab9c1797ea723a164"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P60584, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60584.json""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-014_42cd515df50e	RHEA:51586	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51586		"[{""reference_id"": ""RHEA:51586"", ""source_assertion"": ""Rhea places CHEBI:15378 on the products side of directed RHEA:51586, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/51586\""]/rh:products; http://rdf.rhea-db.org/51584_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_51584_compound_3249/rh:compound -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:51586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 51586 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-015_6fc1fe9742a1	CHEBI:61513	pathwaymech:consumes	RHEA:28419	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28419		"[{""reference_id"": ""RHEA:28419"", ""source_assertion"": ""Rhea places CHEBI:61513 on the substrates side of directed RHEA:28419, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28419\""]/rh:substrates; http://rdf.rhea-db.org/28418_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_28418_compound_6459/rh:compound -> http://rdf.rhea-db.org/Compound_6459/rh:chebi""}]"	"[{""id"": ""RHEA:28419"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28419 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-016_d3de2ae61d6a	CHEBI:16347	pathwaymech:consumes	RHEA:28419	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28419		"[{""reference_id"": ""RHEA:28419"", ""source_assertion"": ""Rhea places CHEBI:16347 on the substrates side of directed RHEA:28419, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28419\""]/rh:substrates; http://rdf.rhea-db.org/28418_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_28418_compound_4231/rh:compound -> http://rdf.rhea-db.org/Compound_4231/rh:chebi""}]"	"[{""id"": ""RHEA:28419"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28419 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-017_058345cc5508	RHEA:28419	pathwaymech:produces	CHEBI:60932	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28419		"[{""reference_id"": ""RHEA:28419"", ""source_assertion"": ""Rhea places CHEBI:60932 on the products side of directed RHEA:28419, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28419\""]/rh:products; http://rdf.rhea-db.org/28418_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_28418_compound_6425/rh:compound -> http://rdf.rhea-db.org/Compound_6425/rh:chebi""}]"	"[{""id"": ""RHEA:28419"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28419 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-018_c673f064bae2	RHEA:28419	pathwaymech:produces	CHEBI:16244	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28419		"[{""reference_id"": ""RHEA:28419"", ""source_assertion"": ""Rhea places CHEBI:16244 on the products side of directed RHEA:28419, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28419\""]/rh:products; http://rdf.rhea-db.org/28418_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_28418_compound_5286/rh:compound -> http://rdf.rhea-db.org/Compound_5286/rh:chebi""}]"	"[{""id"": ""RHEA:28419"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28419 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-019_623c94a5884b	UniProtKB:P31552	pathwaymech:catalyzes	RHEA:28515	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:18266698|RHEA:28515|UniProtKB:P31552	CaiC primes the CoA-linked cycle; this ATP-dependent step does not imply one ATP hydrolyzed per subsequent carnitine reduction. Its other betaine substrates lie outside this native four-reaction route.	"[{""reference_id"": ""UniProtKB:P31552"", ""source_assertion"": ""UniProt assigns RHEA:28514 catalytic activity to P31552 with ECO:0000269/PubMed:18266698 and ECO:0000255/HAMAP-Rule:MF_01524; its function supports the selected pathway transformation."", ""source_locator"": ""comments[3].reaction.reactionCrossReferences; comments[3].reaction.evidences; comments[0].texts[0]""}, {""reference_id"": ""RHEA:28515"", ""source_assertion"": ""Rhea identifies RHEA:28515 as the left_to_right directed form of RHEA:28514."", ""source_locator"": ""http://rdf.rhea-db.org/28514/rh:directionalReaction; http://rdf.rhea-db.org/28515/rh:substrates, rh:products""}, {""quote"": ""the main in vivo role of CaiC was found to be the synthesis of betainyl-CoAs"", ""reference_id"": ""PMID:18266698""}]"	"[{""id"": ""PMID:18266698"", ""title"": ""Role of betaine:CoA ligase (CaiC) in the activation of betaines and the transfer of coenzyme A in Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/18266698/""}, {""id"": ""RHEA:28515"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28515 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P31552"", ""source_sha256"": ""4026a9af16b19911465dce0bf3e7aa1765f79a91a088a1f908ae4ccfdd8c9078"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P31552, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31552.json""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-020_dc04c6539251	UniProtKB:P31551	pathwaymech:catalyzes	RHEA:28339	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11551212|RHEA:28339|UniProtKB:P31551	The protein accession denotes CaiD enzyme identity; UniProt describes a homotrimer. The catabolic dehydration direction is selected from a reversible hydration/dehydration reaction, not a free-carnitine dehydratase reaction.	"[{""reference_id"": ""UniProtKB:P31551"", ""source_assertion"": ""UniProt assigns RHEA:28338 catalytic activity to P31551 with ECO:0000269/PubMed:11551212 and ECO:0000255/HAMAP-Rule:MF_01051; its function supports the selected pathway transformation."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences; comments[1].reaction.evidences; comments[0].texts[0]""}, {""reference_id"": ""RHEA:28339"", ""source_assertion"": ""Rhea identifies RHEA:28339 as the left_to_right directed form of RHEA:28338."", ""source_locator"": ""http://rdf.rhea-db.org/28338/rh:directionalReaction; http://rdf.rhea-db.org/28339/rh:substrates, rh:products""}, {""quote"": ""CaiD was shown to be a crotonobetainyl-CoA hydratase"", ""reference_id"": ""PMID:11551212""}]"	"[{""id"": ""PMID:11551212"", ""title"": ""Involvement of coenzyme A esters and two new enzymes, an enoyl-CoA hydratase and a CoA-transferase, in the hydration of crotonobetaine to L-carnitine by Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/11551212/""}, {""id"": ""RHEA:28339"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28339 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P31551"", ""source_sha256"": ""2f14bc353fb9638bea1e8e8b583450f1df8ff3b2c5cbd114169b89807acd5ba1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P31551, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31551.json""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-021_a8960221b775	UniProtKB:P60584	pathwaymech:catalyzes	RHEA:51586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12081978|RHEA:51586|UniProtKB:P60584	The protein accession denotes CaiA enzyme identity; UniProt describes a homotetramer. The selected right-to-left direction of Rhea 51584 reduces crotonobetainyl-CoA. Genetic requirement for fixA/fixB does not identify a directly measured physiological carrier complex or its electron-transfer stoichiometry.	"[{""reference_id"": ""UniProtKB:P60584"", ""source_assertion"": ""UniProt assigns RHEA:51584 catalytic activity to P60584 with ECO:0000269/PubMed:10978161 and ECO:0000255/HAMAP-Rule:MF_01052; its function supports the selected pathway transformation."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences; comments[1].reaction.evidences; comments[0].texts[0]""}, {""reference_id"": ""RHEA:51586"", ""source_assertion"": ""Rhea identifies RHEA:51586 as the right_to_left directed form of RHEA:51584."", ""source_locator"": ""http://rdf.rhea-db.org/51584/rh:directionalReaction; http://rdf.rhea-db.org/51586/rh:substrates, rh:products""}, {""reference_id"": ""PMID:12081978"", ""source_assertion"": ""E. coli fixA and fixB mutants failed to reduce carnitine to gamma-butyrobetaine anaerobically. Electron provision by the neighboring fix operon was proposed, rather than a particular donor-protein reaction being directly established."", ""source_locator"": ""Abstract, final two sentences; Europe PMC resultList.result[id=12081978].abstractText""}]"	"[{""id"": ""PMID:12081978"", ""title"": ""The fixA and fixB genes are necessary for anaerobic carnitine reduction in Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12081978/""}, {""id"": ""RHEA:51586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 51586 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P60584"", ""source_sha256"": ""fb7c50d1e1b6635a32d938f51f83938b983abbd935b8aacab9c1797ea723a164"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P60584, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60584.json""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-022_8fbab8e6f9fe	PathBank:SMP0002051/ProteinComplex/4010	pathwaymech:catalyzes	RHEA:28419	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002051|RHEA:28419|UniProtKB:P31572	The native CaiB homodimer transfers CoA from gamma-butyrobetainyl-CoA to fresh carnitine. The selected direction releases gamma-butyrobetaine and regenerates carnitinyl-CoA; the characterized CoA transfer is reversible.	"[{""reference_id"": ""UniProtKB:P31572"", ""source_assertion"": ""UniProt assigns RHEA:28418 catalytic activity to P31572 with ECO:0000269/PubMed:11551212 and ECO:0000255/HAMAP-Rule:MF_01050; its function supports the selected pathway transformation."", ""source_locator"": ""comments[2].reaction.reactionCrossReferences; comments[2].reaction.evidences; comments[0].texts[0]""}, {""reference_id"": ""RHEA:28419"", ""source_assertion"": ""Rhea identifies RHEA:28419 as the left_to_right directed form of RHEA:28418."", ""source_locator"": ""http://rdf.rhea-db.org/28418/rh:directionalReaction; http://rdf.rhea-db.org/28419/rh:substrates, rh:products""}, {""reference_id"": ""PathBank:SMP0002051"", ""source_assertion"": ""Native ReactionCatalysis/5916 connects ProteinComplex/4010 to Reactions/5953; its single protein component is CaiB (UniProt P31572), with stoichiometric coefficient 2."", ""source_locator"": ""PW002037.owl: ReactionCatalysis/5916/bp:controller, bp:controlled; ProteinComplex/4010/bp:component, bp:componentStoichiometry""}]"	"[{""id"": ""PathBank:SMP0002051"", ""source_sha256"": ""39b0822d459657d796d23dffff8283ff911a64d9f811d29b23ed7133c683a1c5"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002037.owl"", ""title"": ""PathBank L-Carnitine Degradation I, native BioPAX member PW002037.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:28419"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28419 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P31572"", ""source_sha256"": ""fda91b8501d65c986ab6cb82321a3007a736391b430663c51206dd383502f37a"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P31572, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31572.json""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-023_a6420cd4f1cf	PathBank:SMP0002051/ProteinComplex/4010	BFO:0000051	UniProtKB:P31572	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:15518548|PathBank:SMP0002051|UniProtKB:P31572	Two copies of CaiB form the source-defined homodimer; the graph represents membership once and preserves the copy number here and in the evidence.	"[{""reference_id"": ""PathBank:SMP0002051"", ""source_assertion"": ""The native complex has component Protein/6507, linked to UniProt P31572, with stoichiometric coefficient 2."", ""source_locator"": ""PW002037.owl: ProteinComplex/4010/bp:component; Protein/6507/Stoichiometry/2.0/bp:stoichiometricCoefficient; ProteinReference/6507/bp:xref""}, {""reference_id"": ""UniProtKB:P31572"", ""source_assertion"": ""CaiB is a homodimer, supported by ECO:0000269/PubMed:15518548 and ECO:0000255/HAMAP-Rule:MF_01050."", ""source_locator"": ""comments[4].texts[0] (SUBUNIT)""}, {""quote"": ""two monomers are interlaced to form an interlocked dimer"", ""reference_id"": ""PMID:15518548""}]"	"[{""id"": ""PMID:15518548"", ""title"": ""Crystal structure of CaiB, a type-III CoA transferase in carnitine metabolism."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/15518548/""}, {""id"": ""PathBank:SMP0002051"", ""source_sha256"": ""39b0822d459657d796d23dffff8283ff911a64d9f811d29b23ed7133c683a1c5"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002037.owl"", ""title"": ""PathBank L-Carnitine Degradation I, native BioPAX member PW002037.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P31572"", ""source_sha256"": ""fda91b8501d65c986ab6cb82321a3007a736391b430663c51206dd383502f37a"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P31572, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31572.json""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-024_83b359c28ffd	UniProtKB:P60584	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:10209289|UniProtKB:P60584	This is FAD bound to CaiA, separate from the flavin reactive part of the generic electron-transfer flavoprotein in the Rhea redox reaction. The ChEBI charge form follows the curated cofactor cross-reference.	"[{""reference_id"": ""UniProtKB:P60584"", ""source_assertion"": ""CaiA has FAD (CHEBI:57692) as cofactor and binds one FAD per subunit; the annotation cites ECO:0000269/PubMed:10209289 and ECO:0000255/HAMAP-Rule:MF_01052."", ""source_locator"": ""comments[2].cofactors[0]; comments[2].note.texts[0]""}, {""quote"": ""CII contains non-covalently bound FAD in a molar ratio of 1:1."", ""reference_id"": ""PMID:10209289""}]"	"[{""id"": ""PMID:10209289"", ""title"": ""Crotonobetaine reductase from Escherichia coli consists of two proteins."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/10209289/""}, {""id"": ""UniProtKB:P60584"", ""source_sha256"": ""fb7c50d1e1b6635a32d938f51f83938b983abbd935b8aacab9c1797ea723a164"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P60584, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60584.json""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-025_2b9d8d461452	RHEA:28515	BFO:0000050	PathBank:SMP0002051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002051|UniProtKB:P31552	Manual source correspondence based on the native catalyst and biochemical transformation, not a native Rhea cross-reference or exactMatch. Current Rhea chemistry supplies explicit charge/stereo forms and corrects the older map's chemical-identity defects.	"[{""reference_id"": ""PathBank:SMP0002051"", ""source_assertion"": ""PathBank SMP0002051 explicitly includes native Reactions/5950 and its associated catalysis; the controller resolves to P31552."", ""source_locator"": ""PW002037.owl: Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002051\""]/bp:pathwayComponent; ReactionCatalysis/5913/bp:controller, bp:controlled""}, {""reference_id"": ""UniProtKB:P31552"", ""source_assertion"": ""The corresponding enzyme annotation identifies RHEA:28514; this provides the independent reaction-family bridge to RHEA:28515, selected in the native catabolic direction."", ""source_locator"": ""comments[3].reaction.reactionCrossReferences; comments[0]""}]"	"[{""id"": ""PathBank:SMP0002051"", ""source_sha256"": ""39b0822d459657d796d23dffff8283ff911a64d9f811d29b23ed7133c683a1c5"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002037.owl"", ""title"": ""PathBank L-Carnitine Degradation I, native BioPAX member PW002037.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P31552"", ""source_sha256"": ""4026a9af16b19911465dce0bf3e7aa1765f79a91a088a1f908ae4ccfdd8c9078"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P31552, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31552.json""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-026_b30906d1051e	RHEA:28339	BFO:0000050	PathBank:SMP0002051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002051|UniProtKB:P31551	Manual source correspondence based on the native catalyst and biochemical transformation, not a native Rhea cross-reference or exactMatch. Current Rhea chemistry supplies explicit charge/stereo forms and corrects the older map's chemical-identity defects.	"[{""reference_id"": ""PathBank:SMP0002051"", ""source_assertion"": ""PathBank SMP0002051 explicitly includes native Reactions/5951 and its associated catalysis; the controller resolves to P31551."", ""source_locator"": ""PW002037.owl: Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002051\""]/bp:pathwayComponent; ReactionCatalysis/5914/bp:controller, bp:controlled""}, {""reference_id"": ""UniProtKB:P31551"", ""source_assertion"": ""The corresponding enzyme annotation identifies RHEA:28338; this provides the independent reaction-family bridge to RHEA:28339, selected in the native catabolic direction."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences; comments[0]""}]"	"[{""id"": ""PathBank:SMP0002051"", ""source_sha256"": ""39b0822d459657d796d23dffff8283ff911a64d9f811d29b23ed7133c683a1c5"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002037.owl"", ""title"": ""PathBank L-Carnitine Degradation I, native BioPAX member PW002037.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P31551"", ""source_sha256"": ""2f14bc353fb9638bea1e8e8b583450f1df8ff3b2c5cbd114169b89807acd5ba1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P31551, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31551.json""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-027_4b74c149a006	RHEA:51586	BFO:0000050	PathBank:SMP0002051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002051|UniProtKB:P60584	Manual source correspondence based on the native catalyst and biochemical transformation, not a native Rhea cross-reference or exactMatch. Current Rhea chemistry supplies explicit charge/stereo forms and corrects the older map's chemical-identity defects.	"[{""reference_id"": ""PathBank:SMP0002051"", ""source_assertion"": ""PathBank SMP0002051 explicitly includes native Reactions/5952 and its associated catalysis; the controller resolves to P60584."", ""source_locator"": ""PW002037.owl: Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002051\""]/bp:pathwayComponent; ReactionCatalysis/5915/bp:controller, bp:controlled""}, {""reference_id"": ""UniProtKB:P60584"", ""source_assertion"": ""The corresponding enzyme annotation identifies RHEA:51584; this provides the independent reaction-family bridge to RHEA:51586, selected in the native catabolic direction."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences; comments[0]""}]"	"[{""id"": ""PathBank:SMP0002051"", ""source_sha256"": ""39b0822d459657d796d23dffff8283ff911a64d9f811d29b23ed7133c683a1c5"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002037.owl"", ""title"": ""PathBank L-Carnitine Degradation I, native BioPAX member PW002037.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P60584"", ""source_sha256"": ""fb7c50d1e1b6635a32d938f51f83938b983abbd935b8aacab9c1797ea723a164"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P60584, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60584.json""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-028_73b4f6a67e14	RHEA:28419	BFO:0000050	PathBank:SMP0002051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002051|UniProtKB:P31572	Manual source correspondence based on the native catalyst and biochemical transformation, not a native Rhea cross-reference or exactMatch. Current Rhea chemistry supplies explicit charge/stereo forms and corrects the older map's chemical-identity defects.	"[{""reference_id"": ""PathBank:SMP0002051"", ""source_assertion"": ""PathBank SMP0002051 explicitly includes native Reactions/5953 and its associated catalysis; the controller resolves to P31572 through complex ProteinComplex/4010."", ""source_locator"": ""PW002037.owl: Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002051\""]/bp:pathwayComponent; ReactionCatalysis/5916/bp:controller, bp:controlled""}, {""reference_id"": ""UniProtKB:P31572"", ""source_assertion"": ""The corresponding enzyme annotation identifies RHEA:28418; this provides the independent reaction-family bridge to RHEA:28419, selected in the native catabolic direction."", ""source_locator"": ""comments[2].reaction.reactionCrossReferences; comments[0]""}]"	"[{""id"": ""PathBank:SMP0002051"", ""source_sha256"": ""39b0822d459657d796d23dffff8283ff911a64d9f811d29b23ed7133c683a1c5"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002037.owl"", ""title"": ""PathBank L-Carnitine Degradation I, native BioPAX member PW002037.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P31572"", ""source_sha256"": ""fda91b8501d65c986ab6cb82321a3007a736391b430663c51206dd383502f37a"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P31572, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31572.json""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-029_fade9aa06434	RHEA:28515	RO:0002413	RHEA:28339	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28339|RHEA:28515	CaiC supplies the initial carnitinyl-CoA pool for CaiD; the subsequent CaiB loop recycles that pool.	"[{""reference_id"": ""RHEA:28515"", ""source_assertion"": ""CHEBI:60932 is a coefficient-1 product of RHEA:28515; this shared chemical provides the material connection between the selected reactions."", ""source_locator"": ""http://rdf.rhea-db.org/28515/rh:products; http://rdf.rhea-db.org/28514_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_28514_compound_6425/rh:compound -> http://rdf.rhea-db.org/Compound_6425/rh:chebi""}, {""reference_id"": ""RHEA:28339"", ""source_assertion"": ""CHEBI:60932 is a coefficient-1 substrate of RHEA:28339; this shared chemical provides the material connection between the selected reactions."", ""source_locator"": ""http://rdf.rhea-db.org/28339/rh:substrates; http://rdf.rhea-db.org/28338_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_28338_compound_6425/rh:compound -> http://rdf.rhea-db.org/Compound_6425/rh:chebi""}]"	"[{""id"": ""RHEA:28339"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28339 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:28515"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28515 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-030_7a481314cf73	RHEA:28339	RO:0002413	RHEA:51586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28339|RHEA:51586	The product CHEBI:60933 is the next selected reaction substrate.	"[{""reference_id"": ""RHEA:28339"", ""source_assertion"": ""CHEBI:60933 is a coefficient-1 product of RHEA:28339; this shared chemical provides the material connection between the selected reactions."", ""source_locator"": ""http://rdf.rhea-db.org/28339/rh:products; http://rdf.rhea-db.org/28338_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_28338_compound_6426/rh:compound -> http://rdf.rhea-db.org/Compound_6426/rh:chebi""}, {""reference_id"": ""RHEA:51586"", ""source_assertion"": ""CHEBI:60933 is a coefficient-1 substrate of RHEA:51586; this shared chemical provides the material connection between the selected reactions."", ""source_locator"": ""http://rdf.rhea-db.org/51586/rh:substrates; http://rdf.rhea-db.org/51584_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_51584_compound_6426/rh:compound -> http://rdf.rhea-db.org/Compound_6426/rh:chebi""}]"	"[{""id"": ""RHEA:28339"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28339 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:51586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 51586 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-031_7aaf5d4b8055	RHEA:51586	RO:0002413	RHEA:28419	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28419|RHEA:51586	The product CHEBI:61513 is the next selected reaction substrate.	"[{""reference_id"": ""RHEA:51586"", ""source_assertion"": ""CHEBI:61513 is a coefficient-1 product of RHEA:51586; this shared chemical provides the material connection between the selected reactions."", ""source_locator"": ""http://rdf.rhea-db.org/51586/rh:products; http://rdf.rhea-db.org/51584_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_51584_compound_6459/rh:compound -> http://rdf.rhea-db.org/Compound_6459/rh:chebi""}, {""reference_id"": ""RHEA:28419"", ""source_assertion"": ""CHEBI:61513 is a coefficient-1 substrate of RHEA:28419; this shared chemical provides the material connection between the selected reactions."", ""source_locator"": ""http://rdf.rhea-db.org/28419/rh:substrates; http://rdf.rhea-db.org/28418_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_28418_compound_6459/rh:compound -> http://rdf.rhea-db.org/Compound_6459/rh:chebi""}]"	"[{""id"": ""RHEA:28419"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28419 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:51586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 51586 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002051_carnitine-edge-032_5964679c15b2	RHEA:28419	RO:0002413	RHEA:28339	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28339|RHEA:28419	CaiB regenerates carnitinyl-CoA for another cycle; this material-flow loop does not assert a temporal order from the native pathwayOrder array.	"[{""reference_id"": ""RHEA:28419"", ""source_assertion"": ""CHEBI:60932 is a coefficient-1 product of RHEA:28419; this shared chemical provides the material connection between the selected reactions."", ""source_locator"": ""http://rdf.rhea-db.org/28419/rh:products; http://rdf.rhea-db.org/28418_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_28418_compound_6425/rh:compound -> http://rdf.rhea-db.org/Compound_6425/rh:chebi""}, {""reference_id"": ""RHEA:28339"", ""source_assertion"": ""CHEBI:60932 is a coefficient-1 substrate of RHEA:28339; this shared chemical provides the material connection between the selected reactions."", ""source_locator"": ""http://rdf.rhea-db.org/28339/rh:substrates; http://rdf.rhea-db.org/28338_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_28338_compound_6425/rh:compound -> http://rdf.rhea-db.org/Compound_6425/rh:chebi""}]"	"[{""id"": ""RHEA:28339"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28339 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:28419"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28419 directed carnitine pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_CYSTSYN-PWY_edge-001_16da80df8e18	CHEBI:33384	pathwaymech:consumes	RHEA:24561	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24561		"[{""reference_id"": ""RHEA:24561"", ""source_assertion"": ""Rhea lists CHEBI:33384 on the substrates side of RHEA:24561 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24561']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24561"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic serine O-acetyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/24561""}]"	""
pathwaymech:MetaCyc_CYSTSYN-PWY_edge-002_c02ff249174e	CHEBI:57288	pathwaymech:consumes	RHEA:24561	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24561		"[{""reference_id"": ""RHEA:24561"", ""source_assertion"": ""Rhea lists CHEBI:57288 on the substrates side of RHEA:24561 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24561']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24561"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic serine O-acetyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/24561""}]"	""
pathwaymech:MetaCyc_CYSTSYN-PWY_edge-003_a293d94faf3e	RHEA:24561	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24561		"[{""reference_id"": ""RHEA:24561"", ""source_assertion"": ""Rhea lists CHEBI:57287 on the products side of RHEA:24561 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24561']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24561"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic serine O-acetyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/24561""}]"	""
pathwaymech:MetaCyc_CYSTSYN-PWY_edge-004_bc93d5bb2dfe	RHEA:24561	pathwaymech:produces	CHEBI:58340	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24561		"[{""reference_id"": ""RHEA:24561"", ""source_assertion"": ""Rhea lists CHEBI:58340 on the products side of RHEA:24561 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24561']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24561"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic serine O-acetyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/24561""}]"	""
pathwaymech:MetaCyc_CYSTSYN-PWY_edge-005_3ccec89df1d5	CHEBI:29919	pathwaymech:consumes	RHEA:14830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14830		"[{""reference_id"": ""RHEA:14830"", ""source_assertion"": ""Rhea lists CHEBI:29919 on the substrates side of RHEA:14830 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14830']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14830"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right cysteine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/14830""}]"	""
pathwaymech:MetaCyc_CYSTSYN-PWY_edge-006_84f964340167	CHEBI:58340	pathwaymech:consumes	RHEA:14830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14830		"[{""reference_id"": ""RHEA:14830"", ""source_assertion"": ""Rhea lists CHEBI:58340 on the substrates side of RHEA:14830 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14830']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14830"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right cysteine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/14830""}]"	""
pathwaymech:MetaCyc_CYSTSYN-PWY_edge-007_20ece03c23d9	RHEA:14830	pathwaymech:produces	CHEBI:30089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14830		"[{""reference_id"": ""RHEA:14830"", ""source_assertion"": ""Rhea lists CHEBI:30089 on the products side of RHEA:14830 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14830']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14830"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right cysteine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/14830""}]"	""
pathwaymech:MetaCyc_CYSTSYN-PWY_edge-008_225c1c20e903	RHEA:14830	pathwaymech:produces	CHEBI:35235	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14830		"[{""reference_id"": ""RHEA:14830"", ""source_assertion"": ""Rhea lists CHEBI:35235 on the products side of RHEA:14830 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14830']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14830"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right cysteine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/14830""}]"	""
pathwaymech:MetaCyc_CYSTSYN-PWY_edge-009_24de569d0fa5	EC:2.3.1.30	pathwaymech:catalyzes	RHEA:24561	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12627979|RHEA:24560		"[{""reference_id"": ""RHEA:24560"", ""source_assertion"": ""Rhea associates EC:2.3.1.30 with the reaction family containing RHEA:24561."", ""source_locator"": ""rh:ec""}, {""quote"": ""Random-order ternary complex reaction mechanism of serine acetyltransferase from Escherichia coli."", ""reference_id"": ""PMID:12627979"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Hindson and Shaw, Biochemistry, 2003"", ""id"": ""PMID:12627979"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12627979/""}, {""id"": ""RHEA:24560"", ""source_version"": ""139"", ""title"": ""RHEA:24560 authority record"", ""url"": ""https://www.rhea-db.org/rhea/24560""}]"	""
pathwaymech:MetaCyc_CYSTSYN-PWY_edge-010_74c5e1f1e608	EC:2.5.1.47	pathwaymech:catalyzes	RHEA:14830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:16546401|RHEA:14829		"[{""reference_id"": ""RHEA:14829"", ""source_assertion"": ""Rhea associates EC:2.5.1.47 with the reaction family containing RHEA:14830."", ""source_locator"": ""rh:ec""}, {""quote"": ""O-Acetylserine sulfhydrylase-B (OASS-B, EC 2.5.1.47) is one of the two isozymes produced by Escherichia coli that catalyze the synthesis of L-cysteine from O-acetyl-L-serine and sulfide."", ""reference_id"": ""PMID:16546401"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Zhao et al., Protein Expression and Purification, 2006"", ""id"": ""PMID:16546401"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/16546401/""}, {""id"": ""RHEA:14829"", ""source_version"": ""139"", ""title"": ""Rhea cysteine synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/14829""}]"	""
pathwaymech:MetaCyc_CYSTSYN-PWY_edge-011_1deb9506c073	RHEA:24561	pathwaymech:precedes	RHEA:14830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CYSTSYN-PWY		"[{""reference_id"": ""MetaCyc:CYSTSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:24561 before RHEA:14830 in this pathway. Shared intermediate: CHEBI:58340."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:CYSTSYN-PWY"", ""source_sha256"": ""d612b58784073115052eba64c7f581f189bc2248205d8fff6db42bc97b33e688"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-cysteine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:CYSTSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_CYSTSYN-PWY_edge-012_d434af35659e	UniProtKB:P0A9D4	pathwaymech:enables	RHEA:24561	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9D4		"[{""reference_id"": ""UniProtKB:P0A9D4"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A9D4 with catalytic activity for the reaction family of RHEA:24561. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A9D4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9D4 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9D4.json""}]"	""
pathwaymech:MetaCyc_CYSTSYN-PWY_edge-013_c2bd91512886	CHEBI:35235	pathwaymech:inhibits	UniProtKB:P0A9D4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9D4		"[{""reference_id"": ""UniProtKB:P0A9D4"", ""source_assertion"": ""UniProt activity-regulation annotation: Sensitive to feedback inhibition by L-cysteine"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P0A9D4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9D4 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9D4.json""}]"	""
pathwaymech:MetaCyc_CYSTSYN-PWY_edge-014_adf0a63ee30b	UniProtKB:P0A9D4	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9D4		"[{""reference_id"": ""UniProtKB:P0A9D4"", ""source_assertion"": ""UniProt locates UniProtKB:P0A9D4 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A9D4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9D4 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9D4.json""}]"	""
pathwaymech:MetaCyc_CYSTSYN-PWY_edge-015_c6be7aae9716	UniProtKB:P0ABK5	pathwaymech:enables	RHEA:14830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ABK5		"[{""reference_id"": ""UniProtKB:P0ABK5"", ""source_assertion"": ""UniProt annotates UniProtKB:P0ABK5 with catalytic activity for the reaction family of RHEA:14830. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0ABK5"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0ABK5 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABK5.json""}]"	""
pathwaymech:MetaCyc_CYSTSYN-PWY_edge-016_1ae12fc5d273	UniProtKB:P0ABK5	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ABK5		"[{""reference_id"": ""UniProtKB:P0ABK5"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P0ABK5 (evidence: ECO:0000269). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0ABK5"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0ABK5 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABK5.json""}]"	""
pathwaymech:MetaCyc_CYSTSYN-PWY_edge-017_fb307d0390a6	UniProtKB:P16703	pathwaymech:enables	RHEA:14830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16703		"[{""reference_id"": ""UniProtKB:P16703"", ""source_assertion"": ""UniProt annotates UniProtKB:P16703 with catalytic activity for the reaction family of RHEA:14830. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P16703"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P16703 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P16703.json""}]"	""
pathwaymech:MetaCyc_CYSTSYN-PWY_edge-018_d5da76ab0ed3	UniProtKB:P16703	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16703		"[{""reference_id"": ""UniProtKB:P16703"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P16703 (evidence: curated annotation). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P16703"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P16703 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P16703.json""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_edge-001_9c576d3c6470	gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN	BFO:0000050	GO:0019344	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYSDEGR-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN BFO:0000050 gomodel:YeastPathways_HOMOCYSDEGR-PWY-1/YeastPathways_HOMOCYSDEGR-PWY-1."", ""source_locator"": ""./YeastPathways_HOMOCYSDEGR-PWY-1.json#/facts/0; endpoint types: /individuals/9/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_HOMOCYSDEGR-PWY-1.json"", ""title"": ""GO-CAM L-cysteine biosynthesis III from L-homocysteine model YeastPathways_HOMOCYSDEGR-PWY-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_edge-002_471d8996f165	gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN	RO:0002234	CHEBI:58161	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYSDEGR-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_58161_CYSTATHIONINE-BETA-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYSDEGR-PWY-1.json#/facts/1; endpoint types: /individuals/9/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_HOMOCYSDEGR-PWY-1.json"", ""title"": ""GO-CAM L-cysteine biosynthesis III from L-homocysteine model YeastPathways_HOMOCYSDEGR-PWY-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_edge-003_0d3c598e6884	gomodel:CYSTAGLY-RXN	RO:0002233	CHEBI:58161	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYSDEGR-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CYSTAGLY-RXN RO:0002233 gomodel:CHEBI_58161_CYSTATHIONINE-BETA-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYSDEGR-PWY-1.json#/facts/2; endpoint types: /individuals/8/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_HOMOCYSDEGR-PWY-1.json"", ""title"": ""GO-CAM L-cysteine biosynthesis III from L-homocysteine model YeastPathways_HOMOCYSDEGR-PWY-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_edge-004_5d5f41e2b401	gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN	RO:0002413	gomodel:CYSTAGLY-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYSDEGR-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN RO:0002413 gomodel:CYSTAGLY-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYSDEGR-PWY-1.json#/facts/3; endpoint types: /individuals/9/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_HOMOCYSDEGR-PWY-1.json"", ""title"": ""GO-CAM L-cysteine biosynthesis III from L-homocysteine model YeastPathways_HOMOCYSDEGR-PWY-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_edge-005_c598cf4c5310	gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYSDEGR-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_15377_CYSTATHIONINE-BETA-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYSDEGR-PWY-1.json#/facts/4; endpoint types: /individuals/9/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_HOMOCYSDEGR-PWY-1.json"", ""title"": ""GO-CAM L-cysteine biosynthesis III from L-homocysteine model YeastPathways_HOMOCYSDEGR-PWY-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_edge-006_20a012f45c4a	gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYSDEGR-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN BFO:0000066 gomodel:reaction_CYSTATHIONINE-BETA-SYNTHASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_HOMOCYSDEGR-PWY-1.json#/facts/5; endpoint types: /individuals/9/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_HOMOCYSDEGR-PWY-1.json"", ""title"": ""GO-CAM L-cysteine biosynthesis III from L-homocysteine model YeastPathways_HOMOCYSDEGR-PWY-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_edge-007_bfc8fa07ae9b	gomodel:CYSTAGLY-RXN	BFO:0000050	GO:0019344	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYSDEGR-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CYSTAGLY-RXN BFO:0000050 gomodel:YeastPathways_HOMOCYSDEGR-PWY-1/YeastPathways_HOMOCYSDEGR-PWY-1."", ""source_locator"": ""./YeastPathways_HOMOCYSDEGR-PWY-1.json#/facts/6; endpoint types: /individuals/8/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_HOMOCYSDEGR-PWY-1.json"", ""title"": ""GO-CAM L-cysteine biosynthesis III from L-homocysteine model YeastPathways_HOMOCYSDEGR-PWY-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_edge-008_314cd742cddd	gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN	RO:0002233	CHEBI:58199	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYSDEGR-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_58199_CYSTATHIONINE-BETA-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYSDEGR-PWY-1.json#/facts/7; endpoint types: /individuals/9/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_HOMOCYSDEGR-PWY-1.json"", ""title"": ""GO-CAM L-cysteine biosynthesis III from L-homocysteine model YeastPathways_HOMOCYSDEGR-PWY-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_edge-009_cca6defcf499	gomodel:CYSTAGLY-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYSDEGR-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CYSTAGLY-RXN RO:0002233 gomodel:CHEBI_15377_CYSTAGLY-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYSDEGR-PWY-1.json#/facts/8; endpoint types: /individuals/8/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_HOMOCYSDEGR-PWY-1.json"", ""title"": ""GO-CAM L-cysteine biosynthesis III from L-homocysteine model YeastPathways_HOMOCYSDEGR-PWY-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_edge-010_40298f3421fd	gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN	RO:0002233	CHEBI:33384	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYSDEGR-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_33384_CYSTATHIONINE-BETA-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYSDEGR-PWY-1.json#/facts/9; endpoint types: /individuals/9/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_HOMOCYSDEGR-PWY-1.json"", ""title"": ""GO-CAM L-cysteine biosynthesis III from L-homocysteine model YeastPathways_HOMOCYSDEGR-PWY-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_edge-011_32adfe988ac5	SGD:S000003387	pathwaymech:enables	gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYSDEGR-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CYSTATHIONINE-BETA-SYNTHASE-RXN RO:0002333 gomodel:YGR155W-MONOMER_CYSTATHIONINE-BETA-SYNTHASE-RXN_controller."", ""source_locator"": ""./YeastPathways_HOMOCYSDEGR-PWY-1.json#/facts/10; endpoint types: /individuals/9/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_HOMOCYSDEGR-PWY-1.json"", ""title"": ""GO-CAM L-cysteine biosynthesis III from L-homocysteine model YeastPathways_HOMOCYSDEGR-PWY-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_edge-012_52b9ecb6f015	gomodel:CYSTAGLY-RXN	RO:0002234	CHEBI:35235	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYSDEGR-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CYSTAGLY-RXN RO:0002234 gomodel:CHEBI_35235_CYSTAGLY-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYSDEGR-PWY-1.json#/facts/11; endpoint types: /individuals/8/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_HOMOCYSDEGR-PWY-1.json"", ""title"": ""GO-CAM L-cysteine biosynthesis III from L-homocysteine model YeastPathways_HOMOCYSDEGR-PWY-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_edge-013_d31149236390	SGD:S000000010	pathwaymech:enables	gomodel:CYSTAGLY-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYSDEGR-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CYSTAGLY-RXN RO:0002333 gomodel:YAL012W-MONOMER_CYSTAGLY-RXN_controller."", ""source_locator"": ""./YeastPathways_HOMOCYSDEGR-PWY-1.json#/facts/12; endpoint types: /individuals/8/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_HOMOCYSDEGR-PWY-1.json"", ""title"": ""GO-CAM L-cysteine biosynthesis III from L-homocysteine model YeastPathways_HOMOCYSDEGR-PWY-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_edge-014_0adac673c713	gomodel:CYSTAGLY-RXN	RO:0002234	CHEBI:16763	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYSDEGR-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CYSTAGLY-RXN RO:0002234 gomodel:CHEBI_16763_CYSTAGLY-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYSDEGR-PWY-1.json#/facts/13; endpoint types: /individuals/8/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_HOMOCYSDEGR-PWY-1.json"", ""title"": ""GO-CAM L-cysteine biosynthesis III from L-homocysteine model YeastPathways_HOMOCYSDEGR-PWY-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_edge-015_9594dcacced1	gomodel:CYSTAGLY-RXN	RO:0002234	CHEBI:16134	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYSDEGR-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CYSTAGLY-RXN RO:0002234 gomodel:CHEBI_16134_CYSTAGLY-RXN."", ""source_locator"": ""./YeastPathways_HOMOCYSDEGR-PWY-1.json#/facts/14; endpoint types: /individuals/8/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_HOMOCYSDEGR-PWY-1.json"", ""title"": ""GO-CAM L-cysteine biosynthesis III from L-homocysteine model YeastPathways_HOMOCYSDEGR-PWY-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_edge-016_0f4fce1d2249	gomodel:CYSTAGLY-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_HOMOCYSDEGR-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CYSTAGLY-RXN BFO:0000066 gomodel:reaction_CYSTAGLY-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_HOMOCYSDEGR-PWY-1.json#/facts/15; endpoint types: /individuals/8/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_HOMOCYSDEGR-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_HOMOCYSDEGR-PWY-1.json"", ""title"": ""GO-CAM L-cysteine biosynthesis III from L-homocysteine model YeastPathways_HOMOCYSDEGR-PWY-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_location-c78838968de5_3aa4fc69816b	SGD:S000000010	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31373	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P31373"", ""source_assertion"": ""UniProtKB:P31373 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/839/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P31373"", ""source_assertion"": ""UniProtKB:P31373 has the exact SGD cross-reference SGD:S000000010."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/839/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P31373"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P31373 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_cofactor-c111bc18655d_dcc61f66948e	SGD:S000003387	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32582	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P32582"", ""source_assertion"": ""UniProtKB:P32582 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/958/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P32582"", ""source_assertion"": ""UniProtKB:P32582 has the exact SGD cross-reference SGD:S000003387."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/958/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32582"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P32582 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_HOMOCYSDEGR-PWY-1_cofactor-61049165bd4d_bd87211d38d5	SGD:S000000010	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31373	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:12715888)	"[{""reference_id"": ""UniProtKB:P31373"", ""source_assertion"": ""UniProtKB:P31373 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/839/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P31373"", ""source_assertion"": ""UniProtKB:P31373 has the exact SGD cross-reference SGD:S000000010."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/839/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P31373"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P31373 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-001_234490142666	CHEBI:17617	pathwaymech:consumes	RHEA:12377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12377		"[{""reference_id"": ""RHEA:12377"", ""source_assertion"": ""Rhea lists CHEBI:17617 on the substrates side of RHEA:12377 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12377']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12377"", ""source_version"": ""139"", ""title"": ""Rhea L-fuculose-1-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12377""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-002_f432f281aeb9	CHEBI:30616	pathwaymech:consumes	RHEA:12377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12377		"[{""reference_id"": ""RHEA:12377"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:12377 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12377']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12377"", ""source_version"": ""139"", ""title"": ""Rhea L-fuculose-1-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12377""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-003_0531faebc0db	RHEA:12377	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12377		"[{""reference_id"": ""RHEA:12377"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:12377 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12377']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12377"", ""source_version"": ""139"", ""title"": ""Rhea L-fuculose-1-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12377""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-004_9eec831395b9	RHEA:12377	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12377		"[{""reference_id"": ""RHEA:12377"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:12377 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12377']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12377"", ""source_version"": ""139"", ""title"": ""Rhea L-fuculose-1-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12377""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-005_61b45eac7322	RHEA:12377	pathwaymech:produces	CHEBI:57846	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12377		"[{""reference_id"": ""RHEA:12377"", ""source_assertion"": ""Rhea lists CHEBI:57846 on the products side of RHEA:12377 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12377']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12377"", ""source_version"": ""139"", ""title"": ""Rhea L-fuculose-1-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12377""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-006_41c180f70bdd	CHEBI:57846	pathwaymech:consumes	RHEA:12934	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12934		"[{""reference_id"": ""RHEA:12934"", ""source_assertion"": ""Rhea lists CHEBI:57846 on the substrates side of RHEA:12934 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12934']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12934"", ""source_version"": ""139"", ""title"": ""Rhea L-fuculose-1-phosphate-cleaving direction"", ""url"": ""https://www.rhea-db.org/rhea/12934""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-007_070583044716	RHEA:12934	pathwaymech:produces	CHEBI:18041	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12934		"[{""reference_id"": ""RHEA:12934"", ""source_assertion"": ""Rhea lists CHEBI:18041 on the products side of RHEA:12934 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12934']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12934"", ""source_version"": ""139"", ""title"": ""Rhea L-fuculose-1-phosphate-cleaving direction"", ""url"": ""https://www.rhea-db.org/rhea/12934""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-008_044b3c38dfee	RHEA:12934	pathwaymech:produces	CHEBI:57642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12934		"[{""reference_id"": ""RHEA:12934"", ""source_assertion"": ""Rhea lists CHEBI:57642 on the products side of RHEA:12934 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12934']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12934"", ""source_version"": ""139"", ""title"": ""Rhea L-fuculose-1-phosphate-cleaving direction"", ""url"": ""https://www.rhea-db.org/rhea/12934""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-009_3ece7f8af978	CHEBI:42589	pathwaymech:consumes	RHEA:25582	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25582		"[{""reference_id"": ""RHEA:25582"", ""source_assertion"": ""Rhea lists CHEBI:42589 on the substrates side of RHEA:25582 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25582']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25582"", ""source_version"": ""139"", ""title"": ""RHEA:25582 authority record"", ""url"": ""https://www.rhea-db.org/rhea/25582""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-010_b9200c27b96a	RHEA:25582	pathwaymech:produces	CHEBI:42548	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25582		"[{""reference_id"": ""RHEA:25582"", ""source_assertion"": ""Rhea lists CHEBI:42548 on the products side of RHEA:25582 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25582']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25582"", ""source_version"": ""139"", ""title"": ""RHEA:25582 authority record"", ""url"": ""https://www.rhea-db.org/rhea/25582""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-011_6f9326894e81	CHEBI:2181	pathwaymech:consumes	RHEA:17234	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17234		"[{""reference_id"": ""RHEA:17234"", ""source_assertion"": ""Rhea lists CHEBI:2181 on the substrates side of RHEA:17234 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17234']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17234"", ""source_version"": ""139"", ""title"": ""RHEA:17234 authority record"", ""url"": ""https://www.rhea-db.org/rhea/17234""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-012_135ff6c5fc19	RHEA:17234	pathwaymech:produces	CHEBI:17617	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17234		"[{""reference_id"": ""RHEA:17234"", ""source_assertion"": ""Rhea lists CHEBI:17617 on the products side of RHEA:17234 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17234']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17234"", ""source_version"": ""139"", ""title"": ""RHEA:17234 authority record"", ""url"": ""https://www.rhea-db.org/rhea/17234""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-013_78cc29650251	EC:5.1.3.29	pathwaymech:catalyzes	RHEA:25582	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25580		"[{""reference_id"": ""RHEA:25580"", ""source_assertion"": ""Rhea associates EC:5.1.3.29 with the reaction family containing RHEA:25582."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:25580"", ""source_version"": ""139"", ""title"": ""Rhea L-fucose mutarotase reaction"", ""url"": ""https://www.rhea-db.org/rhea/25580""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-014_dbb381e0cf26	EC:5.3.1.25	pathwaymech:catalyzes	RHEA:17234	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17233		"[{""reference_id"": ""RHEA:17233"", ""source_assertion"": ""Rhea associates EC:5.3.1.25 with the reaction family containing RHEA:17234."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:17233"", ""source_version"": ""139"", ""title"": ""Rhea L-fucose isomerase reaction"", ""url"": ""https://www.rhea-db.org/rhea/17233""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-015_1cf43098e1b2	EC:2.7.1.51	pathwaymech:catalyzes	RHEA:12377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12376		"[{""reference_id"": ""RHEA:12376"", ""source_assertion"": ""Rhea associates EC:2.7.1.51 with the reaction family containing RHEA:12377."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:12376"", ""source_version"": ""139"", ""title"": ""Rhea L-fuculokinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/12376""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-016_19de1ca3ab91	EC:4.1.2.17	pathwaymech:catalyzes	RHEA:12934	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12933		"[{""reference_id"": ""RHEA:12933"", ""source_assertion"": ""Rhea associates EC:4.1.2.17 with the reaction family containing RHEA:12934."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:12933"", ""source_version"": ""139"", ""title"": ""Rhea L-fuculose-phosphate aldolase reaction"", ""url"": ""https://www.rhea-db.org/rhea/12933""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-017_5a30f6483c76	RHEA:12377	pathwaymech:precedes	RHEA:12934	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:FUCCAT-PWY		"[{""reference_id"": ""MetaCyc:FUCCAT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:12377 before RHEA:12934 in this pathway. Shared intermediate: CHEBI:57846."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:FUCCAT-PWY"", ""source_sha256"": ""e7eb30711d47e2d28dd77ad7241bdc937641c2dd6cf1690b1ac416e6eb0a551c"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-fucose degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:FUCCAT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-018_c68ea6440d01	RHEA:17234	pathwaymech:precedes	RHEA:12377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:FUCCAT-PWY		"[{""reference_id"": ""MetaCyc:FUCCAT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:17234 before RHEA:12377 in this pathway. Shared intermediate: CHEBI:17617."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:FUCCAT-PWY"", ""source_sha256"": ""e7eb30711d47e2d28dd77ad7241bdc937641c2dd6cf1690b1ac416e6eb0a551c"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-fucose degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:FUCCAT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_FUCCAT-PWY_edge-019_3a96f3acac64	RHEA:25582	pathwaymech:precedes	RHEA:17234	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:FUCCAT-PWY		"[{""reference_id"": ""MetaCyc:FUCCAT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:25582 before RHEA:17234 in this pathway. The source ordering may bridge anomer-specific and broader substrate classes."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:FUCCAT-PWY"", ""source_sha256"": ""e7eb30711d47e2d28dd77ad7241bdc937641c2dd6cf1690b1ac416e6eb0a551c"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-fucose degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:FUCCAT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-001_12d9e5d7f18b	CHEBI:30616	pathwaymech:consumes	RHEA:18475	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18475		"[{""reference_id"": ""RHEA:18475"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:18475 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18475']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18475"", ""source_version"": ""139"", ""title"": ""Rhea 1-(5-phospho-beta-D-ribosyl)-ATP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18475""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-002_134c45b24ec1	CHEBI:58017	pathwaymech:consumes	RHEA:18475	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18475		"[{""reference_id"": ""RHEA:18475"", ""source_assertion"": ""Rhea lists CHEBI:58017 on the substrates side of RHEA:18475 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18475']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18475"", ""source_version"": ""139"", ""title"": ""Rhea 1-(5-phospho-beta-D-ribosyl)-ATP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18475""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-003_4229367c35ba	RHEA:18475	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18475		"[{""reference_id"": ""RHEA:18475"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:18475 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18475']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18475"", ""source_version"": ""139"", ""title"": ""Rhea 1-(5-phospho-beta-D-ribosyl)-ATP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18475""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-004_383ae0687296	RHEA:18475	pathwaymech:produces	CHEBI:73183	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18475		"[{""reference_id"": ""RHEA:18475"", ""source_assertion"": ""Rhea lists CHEBI:73183 on the products side of RHEA:18475 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18475']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18475"", ""source_version"": ""139"", ""title"": ""Rhea 1-(5-phospho-beta-D-ribosyl)-ATP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18475""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-005_8a0a4ab156ef	CHEBI:15377	pathwaymech:consumes	RHEA:22829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22829		"[{""reference_id"": ""RHEA:22829"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:22829 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22829']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22829"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosyl-AMP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22829""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-006_88f40574080a	CHEBI:73183	pathwaymech:consumes	RHEA:22829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22829		"[{""reference_id"": ""RHEA:22829"", ""source_assertion"": ""Rhea lists CHEBI:73183 on the substrates side of RHEA:22829 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22829']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22829"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosyl-AMP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22829""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-007_1edd1f3abd2c	RHEA:22829	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22829		"[{""reference_id"": ""RHEA:22829"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:22829 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22829']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22829"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosyl-AMP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22829""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-008_a563c2d5f223	RHEA:22829	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22829		"[{""reference_id"": ""RHEA:22829"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:22829 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22829']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22829"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosyl-AMP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22829""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-009_876a0ff9c741	RHEA:22829	pathwaymech:produces	CHEBI:59457	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22829		"[{""reference_id"": ""RHEA:22829"", ""source_assertion"": ""Rhea lists CHEBI:59457 on the products side of RHEA:22829 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22829']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22829"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosyl-AMP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22829""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-010_1819a6bfb2b6	CHEBI:15377	pathwaymech:consumes	RHEA:20050	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20050		"[{""reference_id"": ""RHEA:20050"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:20050 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20050']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20050"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribulosylformimino-AICAR-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/20050""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-011_ea9ca3554d12	CHEBI:59457	pathwaymech:consumes	RHEA:20050	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20050		"[{""reference_id"": ""RHEA:20050"", ""source_assertion"": ""Rhea lists CHEBI:59457 on the substrates side of RHEA:20050 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20050']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20050"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribulosylformimino-AICAR-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/20050""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-012_99268c4b5d5f	RHEA:20050	pathwaymech:produces	CHEBI:58435	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20050		"[{""reference_id"": ""RHEA:20050"", ""source_assertion"": ""Rhea lists CHEBI:58435 on the products side of RHEA:20050 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20050']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20050"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribulosylformimino-AICAR-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/20050""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-013_f3c9de030b43	CHEBI:58435	pathwaymech:consumes	RHEA:15470	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15470		"[{""reference_id"": ""RHEA:15470"", ""source_assertion"": ""Rhea lists CHEBI:58435 on the substrates side of RHEA:15470 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15470']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15470"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribulosylformimino-AICAR-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15470""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-014_2e6989ed1701	RHEA:15470	pathwaymech:produces	CHEBI:58525	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15470		"[{""reference_id"": ""RHEA:15470"", ""source_assertion"": ""Rhea lists CHEBI:58525 on the products side of RHEA:15470 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15470']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15470"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribulosylformimino-AICAR-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15470""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-015_2e667f4e1eed	CHEBI:58359	pathwaymech:consumes	RHEA:24794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24794		"[{""reference_id"": ""RHEA:24794"", ""source_assertion"": ""Rhea lists CHEBI:58359 on the substrates side of RHEA:24794 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24794']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24794"", ""source_version"": ""139"", ""title"": ""Rhea imidazoleglycerol-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24794""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-016_c2fc8ab43493	CHEBI:58525	pathwaymech:consumes	RHEA:24794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24794		"[{""reference_id"": ""RHEA:24794"", ""source_assertion"": ""Rhea lists CHEBI:58525 on the substrates side of RHEA:24794 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24794']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24794"", ""source_version"": ""139"", ""title"": ""Rhea imidazoleglycerol-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24794""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-017_e566a2fe8b06	RHEA:24794	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24794		"[{""reference_id"": ""RHEA:24794"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:24794 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24794']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24794"", ""source_version"": ""139"", ""title"": ""Rhea imidazoleglycerol-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24794""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-018_126b51de5a96	RHEA:24794	pathwaymech:produces	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24794		"[{""reference_id"": ""RHEA:24794"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the products side of RHEA:24794 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24794']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24794"", ""source_version"": ""139"", ""title"": ""Rhea imidazoleglycerol-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24794""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-019_95c1e04c5bf5	RHEA:24794	pathwaymech:produces	CHEBI:58278	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24794		"[{""reference_id"": ""RHEA:24794"", ""source_assertion"": ""Rhea lists CHEBI:58278 on the products side of RHEA:24794 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24794']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24794"", ""source_version"": ""139"", ""title"": ""Rhea imidazoleglycerol-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24794""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-020_3568bb7a19de	RHEA:24794	pathwaymech:produces	CHEBI:58475	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24794		"[{""reference_id"": ""RHEA:24794"", ""source_assertion"": ""Rhea lists CHEBI:58475 on the products side of RHEA:24794 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24794']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24794"", ""source_version"": ""139"", ""title"": ""Rhea imidazoleglycerol-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24794""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-021_1a4b005ac47a	CHEBI:58278	pathwaymech:consumes	RHEA:11041	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11041		"[{""reference_id"": ""RHEA:11041"", ""source_assertion"": ""Rhea lists CHEBI:58278 on the substrates side of RHEA:11041 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11041']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11041"", ""source_version"": ""139"", ""title"": ""Rhea imidazole acetol-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/11041""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-022_9edaab7d6f3d	RHEA:11041	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11041		"[{""reference_id"": ""RHEA:11041"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:11041 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11041']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11041"", ""source_version"": ""139"", ""title"": ""Rhea imidazole acetol-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/11041""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-023_348ac6cd64f4	RHEA:11041	pathwaymech:produces	CHEBI:57766	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11041		"[{""reference_id"": ""RHEA:11041"", ""source_assertion"": ""Rhea lists CHEBI:57766 on the products side of RHEA:11041 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11041']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11041"", ""source_version"": ""139"", ""title"": ""Rhea imidazole acetol-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/11041""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-024_b6feab263274	CHEBI:29985	pathwaymech:consumes	RHEA:23746	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23746		"[{""reference_id"": ""RHEA:23746"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the substrates side of RHEA:23746 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23746']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23746"", ""source_version"": ""139"", ""title"": ""Rhea L-histidinol-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23746""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-025_0b5a9dab1684	CHEBI:57766	pathwaymech:consumes	RHEA:23746	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23746		"[{""reference_id"": ""RHEA:23746"", ""source_assertion"": ""Rhea lists CHEBI:57766 on the substrates side of RHEA:23746 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23746']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23746"", ""source_version"": ""139"", ""title"": ""Rhea L-histidinol-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23746""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-026_1cb771f82bea	RHEA:23746	pathwaymech:produces	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23746		"[{""reference_id"": ""RHEA:23746"", ""source_assertion"": ""Rhea lists CHEBI:16810 on the products side of RHEA:23746 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23746']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23746"", ""source_version"": ""139"", ""title"": ""Rhea L-histidinol-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23746""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-027_0e635b20dab4	RHEA:23746	pathwaymech:produces	CHEBI:57980	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23746		"[{""reference_id"": ""RHEA:23746"", ""source_assertion"": ""Rhea lists CHEBI:57980 on the products side of RHEA:23746 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23746']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23746"", ""source_version"": ""139"", ""title"": ""Rhea L-histidinol-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23746""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-028_571debd0cd79	CHEBI:15377	pathwaymech:consumes	RHEA:14466	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14466		"[{""reference_id"": ""RHEA:14466"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:14466 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14466']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14466"", ""source_version"": ""139"", ""title"": ""Rhea L-histidinol-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14466""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-029_1db8b3c34623	CHEBI:57980	pathwaymech:consumes	RHEA:14466	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14466		"[{""reference_id"": ""RHEA:14466"", ""source_assertion"": ""Rhea lists CHEBI:57980 on the substrates side of RHEA:14466 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14466']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14466"", ""source_version"": ""139"", ""title"": ""Rhea L-histidinol-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14466""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-030_2ff62f668a65	RHEA:14466	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14466		"[{""reference_id"": ""RHEA:14466"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:14466 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14466']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14466"", ""source_version"": ""139"", ""title"": ""Rhea L-histidinol-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14466""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-031_211ce403d938	RHEA:14466	pathwaymech:produces	CHEBI:57699	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14466		"[{""reference_id"": ""RHEA:14466"", ""source_assertion"": ""Rhea lists CHEBI:57699 on the products side of RHEA:14466 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14466']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14466"", ""source_version"": ""139"", ""title"": ""Rhea L-histidinol-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14466""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-032_3613b84210a6	CHEBI:57540	pathwaymech:consumes	RHEA:33800	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33800		"[{""reference_id"": ""RHEA:33800"", ""source_assertion"": ""Rhea lists CHEBI:57540 on the substrates side of RHEA:33800 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33800']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:33800"", ""source_version"": ""139"", ""title"": ""Rhea L-histidinal-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/33800""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-033_53eaa1670faf	CHEBI:57699	pathwaymech:consumes	RHEA:33800	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33800		"[{""reference_id"": ""RHEA:33800"", ""source_assertion"": ""Rhea lists CHEBI:57699 on the substrates side of RHEA:33800 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33800']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:33800"", ""source_version"": ""139"", ""title"": ""Rhea L-histidinal-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/33800""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-034_b7fa98744c35	RHEA:33800	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33800		"[{""reference_id"": ""RHEA:33800"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:33800 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33800']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:33800"", ""source_version"": ""139"", ""title"": ""Rhea L-histidinal-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/33800""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-035_4748884b1896	RHEA:33800	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33800		"[{""reference_id"": ""RHEA:33800"", ""source_assertion"": ""Rhea lists CHEBI:57945 on the products side of RHEA:33800 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33800']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:33800"", ""source_version"": ""139"", ""title"": ""Rhea L-histidinal-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/33800""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-036_d9f59c112a75	RHEA:33800	pathwaymech:produces	CHEBI:64802	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33800		"[{""reference_id"": ""RHEA:33800"", ""source_assertion"": ""Rhea lists CHEBI:64802 on the products side of RHEA:33800 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33800']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:33800"", ""source_version"": ""139"", ""title"": ""Rhea L-histidinal-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/33800""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-037_7d7f02d4b88d	CHEBI:15377	pathwaymech:consumes	RHEA:33804	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33804		"[{""reference_id"": ""RHEA:33804"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:33804 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33804']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:33804"", ""source_version"": ""139"", ""title"": ""Rhea L-histidine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/33804""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-038_e45b9a25d382	CHEBI:57540	pathwaymech:consumes	RHEA:33804	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33804		"[{""reference_id"": ""RHEA:33804"", ""source_assertion"": ""Rhea lists CHEBI:57540 on the substrates side of RHEA:33804 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33804']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:33804"", ""source_version"": ""139"", ""title"": ""Rhea L-histidine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/33804""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-039_193cc8fe6f6c	CHEBI:64802	pathwaymech:consumes	RHEA:33804	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33804		"[{""reference_id"": ""RHEA:33804"", ""source_assertion"": ""Rhea lists CHEBI:64802 on the substrates side of RHEA:33804 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33804']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:33804"", ""source_version"": ""139"", ""title"": ""Rhea L-histidine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/33804""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-040_d4b3f3f3616a	RHEA:33804	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33804		"[{""reference_id"": ""RHEA:33804"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:33804 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33804']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:33804"", ""source_version"": ""139"", ""title"": ""Rhea L-histidine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/33804""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-041_7bf7be392cea	RHEA:33804	pathwaymech:produces	CHEBI:57595	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33804		"[{""reference_id"": ""RHEA:33804"", ""source_assertion"": ""Rhea lists CHEBI:57595 on the products side of RHEA:33804 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33804']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:33804"", ""source_version"": ""139"", ""title"": ""Rhea L-histidine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/33804""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-042_9a9873130b97	RHEA:33804	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33804		"[{""reference_id"": ""RHEA:33804"", ""source_assertion"": ""Rhea lists CHEBI:57945 on the products side of RHEA:33804 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33804']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:33804"", ""source_version"": ""139"", ""title"": ""Rhea L-histidine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/33804""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-043_4482a3f1a2ed	EC:2.4.2.17	pathwaymech:catalyzes	RHEA:18475	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18473		"[{""reference_id"": ""RHEA:18473"", ""source_assertion"": ""Rhea associates EC:2.4.2.17 with the reaction family containing RHEA:18475."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:18473"", ""source_version"": ""139"", ""title"": ""Rhea ATP phosphoribosyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/18473""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-044_c64947625193	EC:3.6.1.31	pathwaymech:catalyzes	RHEA:22829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22828		"[{""reference_id"": ""RHEA:22828"", ""source_assertion"": ""Rhea associates EC:3.6.1.31 with the reaction family containing RHEA:22829."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:22828"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosyl-ATP diphosphatase reaction"", ""url"": ""https://www.rhea-db.org/rhea/22828""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-045_66a3adefaf83	EC:3.5.4.19	pathwaymech:catalyzes	RHEA:20050	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20049		"[{""reference_id"": ""RHEA:20049"", ""source_assertion"": ""Rhea associates EC:3.5.4.19 with the reaction family containing RHEA:20050."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:20049"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosyl-AMP cyclohydrolase reaction"", ""url"": ""https://www.rhea-db.org/rhea/20049""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-046_284b8d995bfc	EC:5.3.1.16	pathwaymech:catalyzes	RHEA:15470	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15469		"[{""reference_id"": ""RHEA:15469"", ""source_assertion"": ""Rhea associates EC:5.3.1.16 with the reaction family containing RHEA:15470."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:15469"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribulosylformimino-AICAR-phosphate isomerase reaction"", ""url"": ""https://www.rhea-db.org/rhea/15469""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-047_b751a445b0ec	EC:4.3.2.10	pathwaymech:catalyzes	RHEA:24794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24793		"[{""reference_id"": ""RHEA:24793"", ""source_assertion"": ""Rhea associates EC:4.3.2.10 with the reaction family containing RHEA:24794."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:24793"", ""source_version"": ""139"", ""title"": ""Rhea imidazoleglycerol-phosphate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/24793""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-048_ab51f1f61916	EC:4.2.1.19	pathwaymech:catalyzes	RHEA:11041	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11040		"[{""reference_id"": ""RHEA:11040"", ""source_assertion"": ""Rhea associates EC:4.2.1.19 with the reaction family containing RHEA:11041."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:11040"", ""source_version"": ""139"", ""title"": ""Rhea imidazoleglycerol-phosphate dehydratase reaction"", ""url"": ""https://www.rhea-db.org/rhea/11040""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-049_469088be3792	EC:2.6.1.9	pathwaymech:catalyzes	RHEA:23746	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23744		"[{""reference_id"": ""RHEA:23744"", ""source_assertion"": ""Rhea associates EC:2.6.1.9 with the reaction family containing RHEA:23746."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:23744"", ""source_version"": ""139"", ""title"": ""Rhea histidinol-phosphate aminotransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/23744""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-050_897034a3ca6a	EC:3.1.3.15	pathwaymech:catalyzes	RHEA:14466	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14465		"[{""reference_id"": ""RHEA:14465"", ""source_assertion"": ""Rhea associates EC:3.1.3.15 with the reaction family containing RHEA:14466."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:14465"", ""source_version"": ""139"", ""title"": ""Rhea histidinol-phosphatase reaction"", ""url"": ""https://www.rhea-db.org/rhea/14465""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-051_db31b449a885	EC:1.1.1.23	pathwaymech:catalyzes	RHEA:33800	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HISTSYN-PWY|PMID:11842181		"[{""reference_id"": ""MetaCyc:HISTSYN-PWY"", ""source_assertion"": ""The native pathway assigns EC:1.1.1.23 activity to the enzymatic step represented by RHEA:33800; this is a component step when the EC definition is an overall reaction."", ""source_locator"": ""Pathway/reaction-layout; Reaction/enzymatic-reaction and component-reaction relationships""}, {""reference_id"": ""PMID:11842181"", ""source_assertion"": ""The study describes E. coli HisD catalyzing sequential NAD-dependent oxidations of histidinol to histidinaldehyde and then histidine."", ""source_locator"": ""PubMed Abstract; sequential HisD reactions""}]"	"[{""id"": ""MetaCyc:HISTSYN-PWY"", ""source_sha256"": ""7bd015a53c6f300953ec02977a0552e4d43c2e7e59142d9763788d84e21a1c18"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-histidine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HISTSYN-PWY&detail=full""}, {""id"": ""PMID:11842181"", ""title"": ""Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/11842181/""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-052_12bbd50a0608	EC:1.1.1.23	pathwaymech:catalyzes	RHEA:33804	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HISTSYN-PWY|PMID:11842181		"[{""reference_id"": ""MetaCyc:HISTSYN-PWY"", ""source_assertion"": ""The native pathway assigns EC:1.1.1.23 activity to the enzymatic step represented by RHEA:33804; this is a component step when the EC definition is an overall reaction."", ""source_locator"": ""Pathway/reaction-layout; Reaction/enzymatic-reaction and component-reaction relationships""}, {""reference_id"": ""PMID:11842181"", ""source_assertion"": ""The study describes E. coli HisD catalyzing sequential NAD-dependent oxidations of histidinol to histidinaldehyde and then histidine."", ""source_locator"": ""PubMed Abstract; sequential HisD reactions""}]"	"[{""id"": ""MetaCyc:HISTSYN-PWY"", ""source_sha256"": ""7bd015a53c6f300953ec02977a0552e4d43c2e7e59142d9763788d84e21a1c18"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-histidine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HISTSYN-PWY&detail=full""}, {""id"": ""PMID:11842181"", ""title"": ""Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/11842181/""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-053_56b8e69528bb	RHEA:11041	pathwaymech:precedes	RHEA:23746	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HISTSYN-PWY		"[{""reference_id"": ""MetaCyc:HISTSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:11041 before RHEA:23746 in this pathway. Shared intermediate: CHEBI:57766."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:HISTSYN-PWY"", ""source_sha256"": ""7bd015a53c6f300953ec02977a0552e4d43c2e7e59142d9763788d84e21a1c18"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-histidine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HISTSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-054_05862680e4a7	RHEA:14466	pathwaymech:precedes	RHEA:33800	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HISTSYN-PWY		"[{""reference_id"": ""MetaCyc:HISTSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:14466 before RHEA:33800 in this pathway. Shared intermediate: CHEBI:57699."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:HISTSYN-PWY"", ""source_sha256"": ""7bd015a53c6f300953ec02977a0552e4d43c2e7e59142d9763788d84e21a1c18"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-histidine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HISTSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-055_474c1515b572	RHEA:15470	pathwaymech:precedes	RHEA:24794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HISTSYN-PWY		"[{""reference_id"": ""MetaCyc:HISTSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:15470 before RHEA:24794 in this pathway. Shared intermediate: CHEBI:58525."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:HISTSYN-PWY"", ""source_sha256"": ""7bd015a53c6f300953ec02977a0552e4d43c2e7e59142d9763788d84e21a1c18"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-histidine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HISTSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-056_a19d29e5dff6	RHEA:18475	pathwaymech:precedes	RHEA:22829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HISTSYN-PWY		"[{""reference_id"": ""MetaCyc:HISTSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:18475 before RHEA:22829 in this pathway. Shared intermediate: CHEBI:73183."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:HISTSYN-PWY"", ""source_sha256"": ""7bd015a53c6f300953ec02977a0552e4d43c2e7e59142d9763788d84e21a1c18"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-histidine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HISTSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-057_ed66fb387524	RHEA:20050	pathwaymech:precedes	RHEA:15470	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HISTSYN-PWY		"[{""reference_id"": ""MetaCyc:HISTSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:20050 before RHEA:15470 in this pathway. Shared intermediate: CHEBI:58435."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:HISTSYN-PWY"", ""source_sha256"": ""7bd015a53c6f300953ec02977a0552e4d43c2e7e59142d9763788d84e21a1c18"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-histidine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HISTSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-058_e87c036d42ac	RHEA:22829	pathwaymech:precedes	RHEA:20050	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HISTSYN-PWY		"[{""reference_id"": ""MetaCyc:HISTSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:22829 before RHEA:20050 in this pathway. Shared intermediate: CHEBI:59457."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:HISTSYN-PWY"", ""source_sha256"": ""7bd015a53c6f300953ec02977a0552e4d43c2e7e59142d9763788d84e21a1c18"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-histidine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HISTSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-059_3f9cbc09843d	RHEA:23746	pathwaymech:precedes	RHEA:14466	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HISTSYN-PWY		"[{""reference_id"": ""MetaCyc:HISTSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:23746 before RHEA:14466 in this pathway. Shared intermediate: CHEBI:57980."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:HISTSYN-PWY"", ""source_sha256"": ""7bd015a53c6f300953ec02977a0552e4d43c2e7e59142d9763788d84e21a1c18"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-histidine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HISTSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-060_c3cca5c1b64b	RHEA:24794	pathwaymech:precedes	RHEA:11041	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HISTSYN-PWY		"[{""reference_id"": ""MetaCyc:HISTSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:24794 before RHEA:11041 in this pathway. Shared intermediate: CHEBI:58278."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:HISTSYN-PWY"", ""source_sha256"": ""7bd015a53c6f300953ec02977a0552e4d43c2e7e59142d9763788d84e21a1c18"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-histidine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HISTSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-061_347dcf60fb6b	RHEA:33800	pathwaymech:precedes	RHEA:33804	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HISTSYN-PWY		"[{""reference_id"": ""MetaCyc:HISTSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:33800 before RHEA:33804 in this pathway. Shared intermediate: CHEBI:64802."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:HISTSYN-PWY"", ""source_sha256"": ""7bd015a53c6f300953ec02977a0552e4d43c2e7e59142d9763788d84e21a1c18"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-histidine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HISTSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-062_9b82fc72d03f	UniProtKB:P06986	pathwaymech:enables	RHEA:23746	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06986		"[{""reference_id"": ""UniProtKB:P06986"", ""source_assertion"": ""UniProt annotates UniProtKB:P06986 with catalytic activity for the reaction family of RHEA:23746. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P06986"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P06986 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06986.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-063_5042cfd2e3f6	UniProtKB:P06986	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06986		"[{""reference_id"": ""UniProtKB:P06986"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P06986 (evidence: ECO:0000269). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P06986"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P06986 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06986.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-064_70897abdc511	UniProtKB:P06987	pathwaymech:enables	RHEA:11041	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06987		"[{""reference_id"": ""UniProtKB:P06987"", ""source_assertion"": ""UniProt annotates UniProtKB:P06987 with catalytic activity for the reaction family of RHEA:11041. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P06987"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P06987 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06987.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-065_9732996f3c59	UniProtKB:P06987	pathwaymech:enables	RHEA:14466	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06987		"[{""reference_id"": ""UniProtKB:P06987"", ""source_assertion"": ""UniProt annotates UniProtKB:P06987 with catalytic activity for the reaction family of RHEA:14466. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P06987"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P06987 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06987.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-066_ab0a30d0c89b	UniProtKB:P06987	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06987		"[{""reference_id"": ""UniProtKB:P06987"", ""source_assertion"": ""UniProt locates UniProtKB:P06987 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P06987"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P06987 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06987.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-067_34de1758a2b8	UniProtKB:P06987	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06987		"[{""reference_id"": ""UniProtKB:P06987"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P06987 (evidence: ECO:0000255). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P06987"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P06987 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06987.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-068_18d9d11ad342	UniProtKB:P06987	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06987		"[{""reference_id"": ""UniProtKB:P06987"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P06987 (evidence: ECO:0000255). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P06987"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P06987 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06987.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-069_76a1153c27df	UniProtKB:P06988	pathwaymech:enables	RHEA:33800	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06988		"[{""reference_id"": ""UniProtKB:P06988"", ""source_assertion"": ""UniProt annotates UniProtKB:P06988 with catalytic activity for the overall reaction containing the native MetaCyc enzymatic component RHEA:33800. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P06988"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P06988 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06988.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-070_d5647ef8bff6	UniProtKB:P06988	pathwaymech:enables	RHEA:33804	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06988		"[{""reference_id"": ""UniProtKB:P06988"", ""source_assertion"": ""UniProt annotates UniProtKB:P06988 with catalytic activity for the overall reaction containing the native MetaCyc enzymatic component RHEA:33804. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P06988"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P06988 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06988.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-071_05472c8419f3	UniProtKB:P06988	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06988		"[{""reference_id"": ""UniProtKB:P06988"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P06988 (evidence: ECO:0000269). Binds 1 zinc ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P06988"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P06988 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06988.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-072_745a111fdbb3	UniProtKB:P06989	pathwaymech:enables	RHEA:22829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06989		"[{""reference_id"": ""UniProtKB:P06989"", ""source_assertion"": ""UniProt annotates UniProtKB:P06989 with catalytic activity for the reaction family of RHEA:22829. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P06989"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P06989 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06989.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-073_4bb54242670f	UniProtKB:P06989	pathwaymech:enables	RHEA:20050	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06989		"[{""reference_id"": ""UniProtKB:P06989"", ""source_assertion"": ""UniProt annotates UniProtKB:P06989 with catalytic activity for the reaction family of RHEA:20050. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P06989"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P06989 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06989.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-074_fd80df454441	UniProtKB:P06989	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06989		"[{""reference_id"": ""UniProtKB:P06989"", ""source_assertion"": ""UniProt locates UniProtKB:P06989 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P06989"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P06989 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06989.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-075_a249102e5316	UniProtKB:P10371	pathwaymech:enables	RHEA:15470	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10371		"[{""reference_id"": ""UniProtKB:P10371"", ""source_assertion"": ""UniProt annotates UniProtKB:P10371 with catalytic activity for the reaction family of RHEA:15470. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P10371"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P10371 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P10371.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-076_73fc46f4a072	UniProtKB:P10371	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10371		"[{""reference_id"": ""UniProtKB:P10371"", ""source_assertion"": ""UniProt locates UniProtKB:P10371 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P10371"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P10371 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P10371.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-077_0aee32d5e5a7	UniProtKB:P60595	pathwaymech:enables	RHEA:24794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P60595		"[{""reference_id"": ""UniProtKB:P60595"", ""source_assertion"": ""UniProt annotates UniProtKB:P60595 with catalytic activity for the reaction family of RHEA:24794. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P60595"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P60595 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60595.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-078_ba11d5bd1c94	UniProtKB:P60595	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P60595		"[{""reference_id"": ""UniProtKB:P60595"", ""source_assertion"": ""UniProt locates UniProtKB:P60595 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P60595"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P60595 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60595.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-079_15b7bc3bd1b7	UniProtKB:P60664	pathwaymech:enables	RHEA:24794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P60664		"[{""reference_id"": ""UniProtKB:P60664"", ""source_assertion"": ""UniProt annotates UniProtKB:P60664 with catalytic activity for the reaction family of RHEA:24794. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P60664"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P60664 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60664.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-080_5517d82a47a9	UniProtKB:P60664	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P60664		"[{""reference_id"": ""UniProtKB:P60664"", ""source_assertion"": ""UniProt locates UniProtKB:P60664 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P60664"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P60664 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60664.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-081_ee6d7e6a3692	UniProtKB:P60757	pathwaymech:enables	RHEA:18475	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P60757		"[{""reference_id"": ""UniProtKB:P60757"", ""source_assertion"": ""UniProt annotates UniProtKB:P60757 with catalytic activity for the reaction family of RHEA:18475. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P60757"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P60757 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60757.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-082_b12424ebacfc	CHEBI:57595	pathwaymech:inhibits	UniProtKB:P60757	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P60757		"[{""reference_id"": ""UniProtKB:P60757"", ""source_assertion"": ""UniProt activity-regulation annotation: Feedback inhibited by histidine. Also inhibited by AMP and PR-ATP"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P60757"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P60757 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60757.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-083_10985888448c	CHEBI:456215	pathwaymech:inhibits	UniProtKB:P60757	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P60757		"[{""reference_id"": ""UniProtKB:P60757"", ""source_assertion"": ""UniProt activity-regulation annotation: Feedback inhibited by histidine. Also inhibited by AMP and PR-ATP"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P60757"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P60757 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60757.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-084_15ef8330d3a5	UniProtKB:P60757	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P60757		"[{""reference_id"": ""UniProtKB:P60757"", ""source_assertion"": ""UniProt locates UniProtKB:P60757 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P60757"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P60757 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60757.json""}]"	""
pathwaymech:MetaCyc_HISTSYN-PWY_edge-085_ab1dbe9bbb6d	UniProtKB:P60757	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P60757		"[{""reference_id"": ""UniProtKB:P60757"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P60757 (evidence: ECO:0000305). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P60757"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P60757 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60757.json""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_edge-001_a6ab1cfbda5a	gomodel:ACETYLHOMOSER-CYS-RXN	RO:0002234	CHEBI:30089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5344		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5344"", ""source_assertion"": ""The model asserts gomodel:ACETYLHOMOSER-CYS-RXN RO:0002234 gomodel:CHEBI_30089_ACETYLHOMOSER-CYS-RXN."", ""source_locator"": ""./YeastPathways_PWY-5344.json#/facts/0; endpoint types: /individuals/0/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5344"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-31; member ./YeastPathways_PWY-5344.json"", ""title"": ""SGD GO-CAM L-homocysteine biosynthesis pathway PWY-5344"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_edge-002_4cbafc6040b0	gomodel:HOMOSERINE-O-ACETYLTRANSFERASE-RXN	RO:0002234	CHEBI:57716	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5344		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5344"", ""source_assertion"": ""The model asserts gomodel:HOMOSERINE-O-ACETYLTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_57716_HOMOSERINE-O-ACETYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5344.json#/facts/1; endpoint types: /individuals/9/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5344"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-31; member ./YeastPathways_PWY-5344.json"", ""title"": ""SGD GO-CAM L-homocysteine biosynthesis pathway PWY-5344"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_edge-003_6f58c7021b79	SGD:S000005221	pathwaymech:enables	gomodel:HOMOSERINE-O-ACETYLTRANSFERASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5344		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5344"", ""source_assertion"": ""The model asserts gomodel:HOMOSERINE-O-ACETYLTRANSFERASE-RXN RO:0002333 gomodel:YNL277W-MONOMER_HOMOSERINE-O-ACETYLTRANSFERASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5344.json#/facts/2; endpoint types: /individuals/9/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5344"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-31; member ./YeastPathways_PWY-5344.json"", ""title"": ""SGD GO-CAM L-homocysteine biosynthesis pathway PWY-5344"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_edge-004_40236572e89d	gomodel:ACETYLHOMOSER-CYS-RXN	RO:0002233	CHEBI:57716	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5344		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5344"", ""source_assertion"": ""The model asserts gomodel:ACETYLHOMOSER-CYS-RXN RO:0002233 gomodel:CHEBI_57716_HOMOSERINE-O-ACETYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5344.json#/facts/3; endpoint types: /individuals/0/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5344"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-31; member ./YeastPathways_PWY-5344.json"", ""title"": ""SGD GO-CAM L-homocysteine biosynthesis pathway PWY-5344"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_edge-005_4b9da38510fb	gomodel:HOMOSERINE-O-ACETYLTRANSFERASE-RXN	RO:0002233	CHEBI:57476	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5344		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5344"", ""source_assertion"": ""The model asserts gomodel:HOMOSERINE-O-ACETYLTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_57476_HOMOSERINE-O-ACETYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5344.json#/facts/4; endpoint types: /individuals/9/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5344"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-31; member ./YeastPathways_PWY-5344.json"", ""title"": ""SGD GO-CAM L-homocysteine biosynthesis pathway PWY-5344"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_edge-006_c9b47b435b18	gomodel:ACETYLHOMOSER-CYS-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5344		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5344"", ""source_assertion"": ""The model asserts gomodel:ACETYLHOMOSER-CYS-RXN RO:0002234 gomodel:CHEBI_15378_ACETYLHOMOSER-CYS-RXN."", ""source_locator"": ""./YeastPathways_PWY-5344.json#/facts/5; endpoint types: /individuals/0/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5344"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-31; member ./YeastPathways_PWY-5344.json"", ""title"": ""SGD GO-CAM L-homocysteine biosynthesis pathway PWY-5344"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_edge-007_162801c04c53	gomodel:HOMOSERINE-O-ACETYLTRANSFERASE-RXN	RO:0002233	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5344		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5344"", ""source_assertion"": ""The model asserts gomodel:HOMOSERINE-O-ACETYLTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_57288_HOMOSERINE-O-ACETYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5344.json#/facts/6; endpoint types: /individuals/9/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5344"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-31; member ./YeastPathways_PWY-5344.json"", ""title"": ""SGD GO-CAM L-homocysteine biosynthesis pathway PWY-5344"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_edge-008_f3ebd8d8e821	gomodel:ACETYLHOMOSER-CYS-RXN	RO:0002233	CHEBI:16136	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5344		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5344"", ""source_assertion"": ""The model asserts gomodel:ACETYLHOMOSER-CYS-RXN RO:0002233 gomodel:CHEBI_16136_ACETYLHOMOSER-CYS-RXN."", ""source_locator"": ""./YeastPathways_PWY-5344.json#/facts/7; endpoint types: /individuals/0/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5344"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-31; member ./YeastPathways_PWY-5344.json"", ""title"": ""SGD GO-CAM L-homocysteine biosynthesis pathway PWY-5344"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_edge-009_41b6e16d1ce2	gomodel:HOMOSERINE-O-ACETYLTRANSFERASE-RXN	BFO:0000050	GO:0071269	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5344		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5344"", ""source_assertion"": ""The model asserts gomodel:HOMOSERINE-O-ACETYLTRANSFERASE-RXN BFO:0000050 gomodel:YeastPathways_PWY-5344/YeastPathways_PWY-5344."", ""source_locator"": ""./YeastPathways_PWY-5344.json#/facts/8; endpoint types: /individuals/9/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5344"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-31; member ./YeastPathways_PWY-5344.json"", ""title"": ""SGD GO-CAM L-homocysteine biosynthesis pathway PWY-5344"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_edge-010_38181d4809d4	gomodel:ACETYLHOMOSER-CYS-RXN	RO:0002234	CHEBI:58199	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5344		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5344"", ""source_assertion"": ""The model asserts gomodel:ACETYLHOMOSER-CYS-RXN RO:0002234 gomodel:CHEBI_58199_ACETYLHOMOSER-CYS-RXN."", ""source_locator"": ""./YeastPathways_PWY-5344.json#/facts/9; endpoint types: /individuals/0/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5344"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-31; member ./YeastPathways_PWY-5344.json"", ""title"": ""SGD GO-CAM L-homocysteine biosynthesis pathway PWY-5344"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_edge-011_12c3dc84ddb1	gomodel:ACETYLHOMOSER-CYS-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5344		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5344"", ""source_assertion"": ""The model asserts gomodel:ACETYLHOMOSER-CYS-RXN BFO:0000066 gomodel:reaction_ACETYLHOMOSER-CYS-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5344.json#/facts/10; endpoint types: /individuals/0/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5344"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-31; member ./YeastPathways_PWY-5344.json"", ""title"": ""SGD GO-CAM L-homocysteine biosynthesis pathway PWY-5344"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_edge-012_c4f5c48c742d	gomodel:HOMOSERINE-O-ACETYLTRANSFERASE-RXN	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5344		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5344"", ""source_assertion"": ""The model asserts gomodel:HOMOSERINE-O-ACETYLTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_57287_HOMOSERINE-O-ACETYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5344.json#/facts/11; endpoint types: /individuals/9/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5344"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-31; member ./YeastPathways_PWY-5344.json"", ""title"": ""SGD GO-CAM L-homocysteine biosynthesis pathway PWY-5344"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_edge-013_a3e2886fc2b4	gomodel:ACETYLHOMOSER-CYS-RXN	BFO:0000050	GO:0071269	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5344		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5344"", ""source_assertion"": ""The model asserts gomodel:ACETYLHOMOSER-CYS-RXN BFO:0000050 gomodel:YeastPathways_PWY-5344/YeastPathways_PWY-5344."", ""source_locator"": ""./YeastPathways_PWY-5344.json#/facts/12; endpoint types: /individuals/0/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5344"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-31; member ./YeastPathways_PWY-5344.json"", ""title"": ""SGD GO-CAM L-homocysteine biosynthesis pathway PWY-5344"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_edge-014_d629725692e1	SGD:S000004294	pathwaymech:enables	gomodel:ACETYLHOMOSER-CYS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5344		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5344"", ""source_assertion"": ""The model asserts gomodel:ACETYLHOMOSER-CYS-RXN RO:0002333 gomodel:YLR303W-MONOMER_ACETYLHOMOSER-CYS-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5344.json#/facts/13; endpoint types: /individuals/0/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5344"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-31; member ./YeastPathways_PWY-5344.json"", ""title"": ""SGD GO-CAM L-homocysteine biosynthesis pathway PWY-5344"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_edge-015_2bf29873ef3c	gomodel:HOMOSERINE-O-ACETYLTRANSFERASE-RXN	RO:0002413	gomodel:ACETYLHOMOSER-CYS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5344		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5344"", ""source_assertion"": ""The model asserts gomodel:HOMOSERINE-O-ACETYLTRANSFERASE-RXN RO:0002413 gomodel:ACETYLHOMOSER-CYS-RXN."", ""source_locator"": ""./YeastPathways_PWY-5344.json#/facts/14; endpoint types: /individuals/9/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5344"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-31; member ./YeastPathways_PWY-5344.json"", ""title"": ""SGD GO-CAM L-homocysteine biosynthesis pathway PWY-5344"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_edge-016_be0148480d44	gomodel:HOMOSERINE-O-ACETYLTRANSFERASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5344		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5344"", ""source_assertion"": ""The model asserts gomodel:HOMOSERINE-O-ACETYLTRANSFERASE-RXN BFO:0000066 gomodel:reaction_HOMOSERINE-O-ACETYLTRANSFERASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5344.json#/facts/15; endpoint types: /individuals/9/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5344"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-31; member ./YeastPathways_PWY-5344.json"", ""title"": ""SGD GO-CAM L-homocysteine biosynthesis pathway PWY-5344"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_location-21e66f4990c3_6c08f9013317	SGD:S000005221	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08465	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11914276); ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P08465"", ""source_assertion"": ""UniProtKB:P08465 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3255/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P08465"", ""source_assertion"": ""UniProtKB:P08465 has the exact SGD cross-reference SGD:S000005221."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3255/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P08465"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P08465 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_location-64cc8c7c9da9_1dd9118ac74d	SGD:S000004294	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06106	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11914276)	"[{""reference_id"": ""UniProtKB:P06106"", ""source_assertion"": ""UniProtKB:P06106 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/125/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P06106"", ""source_assertion"": ""UniProtKB:P06106 has the exact SGD cross-reference SGD:S000004294."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/125/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P06106"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06106 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5344_cofactor-3e59008fc8d5_786697255b43	SGD:S000004294	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06106	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:4609980); ECO:0000269 (PubMed:4947307); ECO:0000269 (PubMed:7765825); ECO:0000269 (PubMed:795806)	"[{""reference_id"": ""UniProtKB:P06106"", ""source_assertion"": ""UniProtKB:P06106 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/125/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P06106"", ""source_assertion"": ""UniProtKB:P06106 has the exact SGD cross-reference SGD:S000004294."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/125/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P06106"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06106 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-001_ad33d8baea37	CHEBI:29991	pathwaymech:consumes	RHEA:23777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23777		"[{""reference_id"": ""RHEA:23777"", ""source_assertion"": ""Rhea lists CHEBI:29991 on the substrates side of RHEA:23777 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23777']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23777"", ""source_version"": ""139"", ""title"": ""Rhea L-aspartate kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/23777""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-002_201a88f9cecc	CHEBI:30616	pathwaymech:consumes	RHEA:23777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23777		"[{""reference_id"": ""RHEA:23777"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:23777 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23777']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23777"", ""source_version"": ""139"", ""title"": ""Rhea L-aspartate kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/23777""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-003_a3ac3a8fad8b	RHEA:23777	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23777		"[{""reference_id"": ""RHEA:23777"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:23777 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23777']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23777"", ""source_version"": ""139"", ""title"": ""Rhea L-aspartate kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/23777""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-004_85a29e8f98f6	RHEA:23777	pathwaymech:produces	CHEBI:57535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23777		"[{""reference_id"": ""RHEA:23777"", ""source_assertion"": ""Rhea lists CHEBI:57535 on the products side of RHEA:23777 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23777']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23777"", ""source_version"": ""139"", ""title"": ""Rhea L-aspartate kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/23777""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-005_f0c2e44dc7c1	CHEBI:15378	pathwaymech:consumes	RHEA:24286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24286		"[{""reference_id"": ""RHEA:24286"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:24286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24286']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24286"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic aspartate-semialdehyde dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/24286""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-006_6a095c7174aa	CHEBI:57535	pathwaymech:consumes	RHEA:24286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24286		"[{""reference_id"": ""RHEA:24286"", ""source_assertion"": ""Rhea lists CHEBI:57535 on the substrates side of RHEA:24286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24286']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24286"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic aspartate-semialdehyde dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/24286""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-007_c239e8efed08	CHEBI:57783	pathwaymech:consumes	RHEA:24286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24286		"[{""reference_id"": ""RHEA:24286"", ""source_assertion"": ""Rhea lists CHEBI:57783 on the substrates side of RHEA:24286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24286']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24286"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic aspartate-semialdehyde dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/24286""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-008_048cf495d38a	RHEA:24286	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24286		"[{""reference_id"": ""RHEA:24286"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:24286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24286']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24286"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic aspartate-semialdehyde dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/24286""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-009_fc677bd608c3	RHEA:24286	pathwaymech:produces	CHEBI:537519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24286		"[{""reference_id"": ""RHEA:24286"", ""source_assertion"": ""Rhea lists CHEBI:537519 on the products side of RHEA:24286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24286']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24286"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic aspartate-semialdehyde dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/24286""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-010_9e7fe8532ca1	RHEA:24286	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24286		"[{""reference_id"": ""RHEA:24286"", ""source_assertion"": ""Rhea lists CHEBI:58349 on the products side of RHEA:24286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24286']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24286"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic aspartate-semialdehyde dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/24286""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-011_7e9740cd3982	CHEBI:15378	pathwaymech:consumes	RHEA:15763	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15763		"[{""reference_id"": ""RHEA:15763"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:15763 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15763']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15763"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic homoserine dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/15763""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-012_5693257059a4	CHEBI:537519	pathwaymech:consumes	RHEA:15763	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15763		"[{""reference_id"": ""RHEA:15763"", ""source_assertion"": ""Rhea lists CHEBI:537519 on the substrates side of RHEA:15763 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15763']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15763"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic homoserine dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/15763""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-013_383bd3ee8a2d	CHEBI:57783	pathwaymech:consumes	RHEA:15763	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15763		"[{""reference_id"": ""RHEA:15763"", ""source_assertion"": ""Rhea lists CHEBI:57783 on the substrates side of RHEA:15763 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15763']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15763"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic homoserine dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/15763""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-014_749c6d0846da	RHEA:15763	pathwaymech:produces	CHEBI:57476	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15763		"[{""reference_id"": ""RHEA:15763"", ""source_assertion"": ""Rhea lists CHEBI:57476 on the products side of RHEA:15763 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15763']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15763"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic homoserine dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/15763""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-015_0e0ff67a7313	RHEA:15763	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15763		"[{""reference_id"": ""RHEA:15763"", ""source_assertion"": ""Rhea lists CHEBI:58349 on the products side of RHEA:15763 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15763']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15763"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic homoserine dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/15763""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-016_79c86c1cfa17	EC:2.7.2.4	pathwaymech:catalyzes	RHEA:23777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23776		"[{""reference_id"": ""RHEA:23776"", ""source_assertion"": ""Rhea associates EC:2.7.2.4 with the reaction family containing RHEA:23777."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:23776"", ""source_version"": ""139"", ""title"": ""RHEA:23776 authority record"", ""url"": ""https://www.rhea-db.org/rhea/23776""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-017_3f4e482088fe	EC:1.2.1.11	pathwaymech:catalyzes	RHEA:24286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24284		"[{""reference_id"": ""RHEA:24284"", ""source_assertion"": ""Rhea associates EC:1.2.1.11 with the reaction family containing RHEA:24286."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:24284"", ""source_version"": ""139"", ""title"": ""RHEA:24284 authority record"", ""url"": ""https://www.rhea-db.org/rhea/24284""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-018_e72e728e424d	EC:1.1.1.3	pathwaymech:catalyzes	RHEA:15763	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:2241177|RHEA:15761		"[{""reference_id"": ""RHEA:15761"", ""source_assertion"": ""Rhea associates EC:1.1.1.3 with the reaction family containing RHEA:15763."", ""source_locator"": ""rh:ec""}, {""quote"": ""aspartokinase-homoserine dehydrogenase I from Escherichia coli"", ""reference_id"": ""PMID:2241177"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Angeles and Viola, Archives of Biochemistry and Biophysics, 1990"", ""id"": ""PMID:2241177"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/2241177/""}, {""id"": ""RHEA:15761"", ""source_version"": ""139"", ""title"": ""RHEA:15761 authority record"", ""url"": ""https://www.rhea-db.org/rhea/15761""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-019_7cc0979c67f9	RHEA:23777	pathwaymech:precedes	RHEA:24286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HOMOSERSYN-PWY		"[{""reference_id"": ""MetaCyc:HOMOSERSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:23777 before RHEA:24286 in this pathway. Shared intermediate: CHEBI:57535."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:HOMOSERSYN-PWY"", ""source_sha256"": ""66b035a9912f3b2a6164c3578ce592a388a095135deb62f13ecb4400aec8754b"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-homoserine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HOMOSERSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-020_55daf6f20c2a	RHEA:24286	pathwaymech:precedes	RHEA:15763	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HOMOSERSYN-PWY		"[{""reference_id"": ""MetaCyc:HOMOSERSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:24286 before RHEA:15763 in this pathway. Shared intermediate: CHEBI:537519."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:HOMOSERSYN-PWY"", ""source_sha256"": ""66b035a9912f3b2a6164c3578ce592a388a095135deb62f13ecb4400aec8754b"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-homoserine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HOMOSERSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-021_6715f74fdf12	UniProtKB:P00561	pathwaymech:enables	RHEA:15763	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00561		"[{""reference_id"": ""UniProtKB:P00561"", ""source_assertion"": ""UniProt annotates UniProtKB:P00561 with catalytic activity for the reaction family of RHEA:15763. Annotation evidence: ECO:0000250; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00561"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00561 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00561.json""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-022_c50ca1f26c92	UniProtKB:P00561	pathwaymech:enables	RHEA:23777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00561		"[{""reference_id"": ""UniProtKB:P00561"", ""source_assertion"": ""UniProt annotates UniProtKB:P00561 with catalytic activity for the reaction family of RHEA:23777. Annotation evidence: ECO:0000250; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00561"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00561 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00561.json""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-023_322a961d38cc	CHEBI:57926	pathwaymech:regulates	UniProtKB:P00561	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00561		"[{""reference_id"": ""UniProtKB:P00561"", ""source_assertion"": ""UniProt activity-regulation annotation: The enzyme activities are regulated allosterically by L-threonine"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P00561"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00561 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00561.json""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-024_40fed536c4b8	UniProtKB:P00562	pathwaymech:enables	RHEA:15763	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00562		"[{""reference_id"": ""UniProtKB:P00562"", ""source_assertion"": ""UniProt annotates UniProtKB:P00562 with catalytic activity for the reaction family of RHEA:15763. Annotation evidence: ECO:0000250; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00562"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00562 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00562.json""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-025_c57d2b30adc5	UniProtKB:P00562	pathwaymech:enables	RHEA:23777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00562		"[{""reference_id"": ""UniProtKB:P00562"", ""source_assertion"": ""UniProt annotates UniProtKB:P00562 with catalytic activity for the reaction family of RHEA:23777. Annotation evidence: ECO:0000250; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00562"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00562 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00562.json""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-026_81b013622935	UniProtKB:P08660	pathwaymech:enables	RHEA:23777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08660		"[{""reference_id"": ""UniProtKB:P08660"", ""source_assertion"": ""UniProt annotates UniProtKB:P08660 with catalytic activity for the reaction family of RHEA:23777. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P08660"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P08660 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08660.json""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-027_af4154b62025	CHEBI:32551	pathwaymech:inhibits	UniProtKB:P08660	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08660		"[{""reference_id"": ""UniProtKB:P08660"", ""source_assertion"": ""UniProt activity-regulation annotation: Synthesis and activity are sensitive to the allosteric inhibitor lysine, one of the end metabolites of the aspartic acid family branched pathway"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P08660"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P08660 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08660.json""}]"	""
pathwaymech:MetaCyc_HOMOSERSYN-PWY_edge-028_c3f08fe10980	UniProtKB:P0A9Q9	pathwaymech:enables	RHEA:24286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9Q9		"[{""reference_id"": ""UniProtKB:P0A9Q9"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A9Q9 with catalytic activity for the reaction family of RHEA:24286. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A9Q9"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9Q9 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9Q9.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-001_d9d85a87c5e4	CHEBI:15361	pathwaymech:consumes	RHEA:27655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27655		"[{""reference_id"": ""RHEA:27655"", ""source_assertion"": ""Rhea lists CHEBI:15361 on the substrates side of RHEA:27655 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27655']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27655"", ""source_version"": ""139"", ""title"": ""Rhea acetohydroxybutanoate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/27655""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-002_96e91ec74bcf	CHEBI:15378	pathwaymech:consumes	RHEA:27655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27655		"[{""reference_id"": ""RHEA:27655"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:27655 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27655']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27655"", ""source_version"": ""139"", ""title"": ""Rhea acetohydroxybutanoate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/27655""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-003_6a322d118666	CHEBI:16763	pathwaymech:consumes	RHEA:27655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27655		"[{""reference_id"": ""RHEA:27655"", ""source_assertion"": ""Rhea lists CHEBI:16763 on the substrates side of RHEA:27655 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27655']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27655"", ""source_version"": ""139"", ""title"": ""Rhea acetohydroxybutanoate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/27655""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-004_58e8e9b34e91	RHEA:27655	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27655		"[{""reference_id"": ""RHEA:27655"", ""source_assertion"": ""Rhea lists CHEBI:16526 on the products side of RHEA:27655 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27655']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27655"", ""source_version"": ""139"", ""title"": ""Rhea acetohydroxybutanoate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/27655""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-005_f8f75453239c	RHEA:27655	pathwaymech:produces	CHEBI:49256	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27655		"[{""reference_id"": ""RHEA:27655"", ""source_assertion"": ""Rhea lists CHEBI:49256 on the products side of RHEA:27655 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27655']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27655"", ""source_version"": ""139"", ""title"": ""Rhea acetohydroxybutanoate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/27655""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-006_27828ea15c58	CHEBI:15378	pathwaymech:consumes	RHEA:13495	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13495		"[{""reference_id"": ""RHEA:13495"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:13495 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13495']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13495"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic acetohydroxy acid isomeroreductase direction"", ""url"": ""https://www.rhea-db.org/rhea/13495""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-007_8eeef65ad63f	CHEBI:49256	pathwaymech:consumes	RHEA:13495	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13495		"[{""reference_id"": ""RHEA:13495"", ""source_assertion"": ""Rhea lists CHEBI:49256 on the substrates side of RHEA:13495 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13495']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13495"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic acetohydroxy acid isomeroreductase direction"", ""url"": ""https://www.rhea-db.org/rhea/13495""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-008_eaf52aaa4fa8	CHEBI:57783	pathwaymech:consumes	RHEA:13495	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13495		"[{""reference_id"": ""RHEA:13495"", ""source_assertion"": ""Rhea lists CHEBI:57783 on the substrates side of RHEA:13495 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13495']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13495"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic acetohydroxy acid isomeroreductase direction"", ""url"": ""https://www.rhea-db.org/rhea/13495""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-009_2a842c09d915	RHEA:13495	pathwaymech:produces	CHEBI:49258	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13495		"[{""reference_id"": ""RHEA:13495"", ""source_assertion"": ""Rhea lists CHEBI:49258 on the products side of RHEA:13495 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13495']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13495"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic acetohydroxy acid isomeroreductase direction"", ""url"": ""https://www.rhea-db.org/rhea/13495""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-010_07458a8e3fba	RHEA:13495	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13495		"[{""reference_id"": ""RHEA:13495"", ""source_assertion"": ""Rhea lists CHEBI:58349 on the products side of RHEA:13495 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13495']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13495"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic acetohydroxy acid isomeroreductase direction"", ""url"": ""https://www.rhea-db.org/rhea/13495""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-011_cea26385d17a	CHEBI:49258	pathwaymech:consumes	RHEA:27695	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27695		"[{""reference_id"": ""RHEA:27695"", ""source_assertion"": ""Rhea lists CHEBI:49258 on the substrates side of RHEA:27695 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27695']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27695"", ""source_version"": ""139"", ""title"": ""Rhea dihydroxy-acid-to-3-methyl-2-oxopentanoate direction"", ""url"": ""https://www.rhea-db.org/rhea/27695""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-012_8446595d9880	RHEA:27695	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27695		"[{""reference_id"": ""RHEA:27695"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:27695 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27695']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27695"", ""source_version"": ""139"", ""title"": ""Rhea dihydroxy-acid-to-3-methyl-2-oxopentanoate direction"", ""url"": ""https://www.rhea-db.org/rhea/27695""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-013_82d9882563d1	RHEA:27695	pathwaymech:produces	CHEBI:35146	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27695		"[{""reference_id"": ""RHEA:27695"", ""source_assertion"": ""Rhea lists CHEBI:35146 on the products side of RHEA:27695 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27695']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27695"", ""source_version"": ""139"", ""title"": ""Rhea dihydroxy-acid-to-3-methyl-2-oxopentanoate direction"", ""url"": ""https://www.rhea-db.org/rhea/27695""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-014_266fd6301a2d	CHEBI:29985	pathwaymech:consumes	RHEA:24803	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24803		"[{""reference_id"": ""RHEA:24803"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the substrates side of RHEA:24803 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24803']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24803"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic L-isoleucine transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/24803""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-015_011b0cfc4c6c	CHEBI:35146	pathwaymech:consumes	RHEA:24803	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24803		"[{""reference_id"": ""RHEA:24803"", ""source_assertion"": ""Rhea lists CHEBI:35146 on the substrates side of RHEA:24803 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24803']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24803"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic L-isoleucine transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/24803""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-016_8dde4e64e9a4	RHEA:24803	pathwaymech:produces	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24803		"[{""reference_id"": ""RHEA:24803"", ""source_assertion"": ""Rhea lists CHEBI:16810 on the products side of RHEA:24803 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24803']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24803"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic L-isoleucine transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/24803""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-017_198e9b81aa81	RHEA:24803	pathwaymech:produces	CHEBI:58045	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24803		"[{""reference_id"": ""RHEA:24803"", ""source_assertion"": ""Rhea lists CHEBI:58045 on the products side of RHEA:24803 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24803']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24803"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic L-isoleucine transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/24803""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-018_5926c062df99	CHEBI:57926	pathwaymech:consumes	RHEA:40676	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40676		"[{""reference_id"": ""RHEA:40676"", ""source_assertion"": ""Rhea lists CHEBI:57926 on the substrates side of RHEA:40676 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40676']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:40676"", ""source_version"": ""139"", ""title"": ""RHEA:40676 authority record"", ""url"": ""https://www.rhea-db.org/rhea/40676""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-019_11d7222787fd	RHEA:40676	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40676		"[{""reference_id"": ""RHEA:40676"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:40676 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40676']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:40676"", ""source_version"": ""139"", ""title"": ""RHEA:40676 authority record"", ""url"": ""https://www.rhea-db.org/rhea/40676""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-020_5c68d973190b	RHEA:40676	pathwaymech:produces	CHEBI:48306	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40676		"[{""reference_id"": ""RHEA:40676"", ""source_assertion"": ""Rhea lists CHEBI:48306 on the products side of RHEA:40676 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40676']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:40676"", ""source_version"": ""139"", ""title"": ""RHEA:40676 authority record"", ""url"": ""https://www.rhea-db.org/rhea/40676""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-021_11911969fc3c	CHEBI:48306	pathwaymech:consumes	RHEA:39968	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:39968		"[{""reference_id"": ""RHEA:39968"", ""source_assertion"": ""Rhea lists CHEBI:48306 on the substrates side of RHEA:39968 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/39968']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:39968"", ""source_version"": ""139"", ""title"": ""RHEA:39968 authority record"", ""url"": ""https://www.rhea-db.org/rhea/39968""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-022_e08765b3103f	RHEA:39968	pathwaymech:produces	CHEBI:76545	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:39968		"[{""reference_id"": ""RHEA:39968"", ""source_assertion"": ""Rhea lists CHEBI:76545 on the products side of RHEA:39968 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/39968']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:39968"", ""source_version"": ""139"", ""title"": ""RHEA:39968 authority record"", ""url"": ""https://www.rhea-db.org/rhea/39968""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-023_8480208b0285	CHEBI:15377	pathwaymech:consumes	RHEA:39976	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:39976		"[{""reference_id"": ""RHEA:39976"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:39976 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/39976']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:39976"", ""source_version"": ""139"", ""title"": ""RHEA:39976 authority record"", ""url"": ""https://www.rhea-db.org/rhea/39976""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-024_6516ef198106	CHEBI:76545	pathwaymech:consumes	RHEA:39976	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:39976		"[{""reference_id"": ""RHEA:39976"", ""source_assertion"": ""Rhea lists CHEBI:76545 on the substrates side of RHEA:39976 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/39976']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:39976"", ""source_version"": ""139"", ""title"": ""RHEA:39976 authority record"", ""url"": ""https://www.rhea-db.org/rhea/39976""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-025_ed21384701f3	RHEA:39976	pathwaymech:produces	CHEBI:16763	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:39976		"[{""reference_id"": ""RHEA:39976"", ""source_assertion"": ""Rhea lists CHEBI:16763 on the products side of RHEA:39976 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/39976']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:39976"", ""source_version"": ""139"", ""title"": ""RHEA:39976 authority record"", ""url"": ""https://www.rhea-db.org/rhea/39976""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-026_1c81f6266252	RHEA:39976	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:39976		"[{""reference_id"": ""RHEA:39976"", ""source_assertion"": ""Rhea lists CHEBI:28938 on the products side of RHEA:39976 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/39976']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:39976"", ""source_version"": ""139"", ""title"": ""RHEA:39976 authority record"", ""url"": ""https://www.rhea-db.org/rhea/39976""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-027_1966f222f2dc	EC:4.3.1.19	pathwaymech:catalyzes	RHEA:40676	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ILEUSYN-PWY|PMID:4573981		"[{""reference_id"": ""MetaCyc:ILEUSYN-PWY"", ""source_assertion"": ""The native pathway assigns EC:4.3.1.19 activity to the enzymatic step represented by RHEA:40676; this is a component step when the EC definition is an overall reaction."", ""source_locator"": ""Pathway/reaction-layout; Reaction/enzymatic-reaction and component-reaction relationships""}, {""quote"": ""Threonine deaminase from Escherichia coli. I. Purification and properties."", ""reference_id"": ""PMID:4573981"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""id"": ""MetaCyc:ILEUSYN-PWY"", ""source_sha256"": ""244072bf8d255c78be815aec586397fd6031dd3b78cc05a2db8aa112f14d5068"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-isoleucine biosynthesis I (from threonine) pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ILEUSYN-PWY&detail=full""}, {""citation"": ""Calhoun et al., Journal of Biological Chemistry, 1973"", ""id"": ""PMID:4573981"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/4573981/""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-028_f8bf9743f6d3	EC:2.2.1.6	pathwaymech:catalyzes	RHEA:27655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:2675968|RHEA:27654		"[{""reference_id"": ""RHEA:27654"", ""source_assertion"": ""Rhea associates EC:2.2.1.6 with the reaction family containing RHEA:27655."", ""source_locator"": ""rh:ec""}, {""quote"": ""Kinetics and mechanism of acetohydroxy acid synthase isozyme III from Escherichia coli."", ""reference_id"": ""PMID:2675968"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Gollop et al., Biochemistry, 1989"", ""id"": ""PMID:2675968"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/2675968/""}, {""id"": ""RHEA:27654"", ""source_version"": ""139"", ""title"": ""Rhea acetohydroxybutanoate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/27654""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-029_e9461aec6aae	EC:1.1.1.86	pathwaymech:catalyzes	RHEA:13495	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:4562389|RHEA:13493		"[{""reference_id"": ""RHEA:13493"", ""source_assertion"": ""Rhea associates EC:1.1.1.86 with the reaction family containing RHEA:13495."", ""source_locator"": ""rh:ec""}, {""quote"": ""Isoleucine and valine metabolism in Escherichia coli. 18. Induction of acetohydroxy acid isomeroreductase"", ""reference_id"": ""PMID:4562389"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Ratzkin et al., Journal of Bacteriology, 1972"", ""id"": ""PMID:4562389"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/4562389/""}, {""id"": ""RHEA:13493"", ""source_version"": ""139"", ""title"": ""Rhea acetohydroxy acid isomeroreductase reaction"", ""url"": ""https://www.rhea-db.org/rhea/13493""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-030_be42617e765f	EC:4.2.1.9	pathwaymech:catalyzes	RHEA:27695	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:13727223|RHEA:27694		"[{""reference_id"": ""RHEA:27694"", ""source_assertion"": ""Rhea associates EC:4.2.1.9 with the reaction family containing RHEA:27695."", ""source_locator"": ""rh:ec""}, {""quote"": ""Dihydroxy acid dehydrase: an enzyme involved in the biosynthesis of isoleucine and valine"", ""reference_id"": ""PMID:13727223"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Myers, Journal of Biological Chemistry, 1961"", ""id"": ""PMID:13727223"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/13727223/""}, {""id"": ""RHEA:27694"", ""source_version"": ""139"", ""title"": ""Rhea dihydroxy-acid dehydratase reaction"", ""url"": ""https://www.rhea-db.org/rhea/27694""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-031_f7608d2c3661	EC:2.6.1.42	pathwaymech:catalyzes	RHEA:24803	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:378964|RHEA:24801		"[{""reference_id"": ""RHEA:24801"", ""source_assertion"": ""Rhea associates EC:2.6.1.42 with the reaction family containing RHEA:24803."", ""source_locator"": ""rh:ec""}, {""quote"": ""Transaminase B from Escherichia coli: quaternary structure, amino-terminal sequence, substrate specificity, and absence of a separate valine-alpha-ketoglutarate activity."", ""reference_id"": ""PMID:378964"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Lee-Peng et al., Journal of Bacteriology, 1979"", ""id"": ""PMID:378964"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/378964/""}, {""id"": ""RHEA:24801"", ""source_version"": ""139"", ""title"": ""Rhea branched-chain-amino-acid transaminase reaction"", ""url"": ""https://www.rhea-db.org/rhea/24801""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-032_c481591facd7	RHEA:13495	pathwaymech:precedes	RHEA:27695	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ILEUSYN-PWY		"[{""reference_id"": ""MetaCyc:ILEUSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:13495 before RHEA:27695 in this pathway. Shared intermediate: CHEBI:49258."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ILEUSYN-PWY"", ""source_sha256"": ""244072bf8d255c78be815aec586397fd6031dd3b78cc05a2db8aa112f14d5068"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-isoleucine biosynthesis I (from threonine) pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ILEUSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-033_879b57f71807	RHEA:27655	pathwaymech:precedes	RHEA:13495	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ILEUSYN-PWY		"[{""reference_id"": ""MetaCyc:ILEUSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:27655 before RHEA:13495 in this pathway. Shared intermediate: CHEBI:49256."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ILEUSYN-PWY"", ""source_sha256"": ""244072bf8d255c78be815aec586397fd6031dd3b78cc05a2db8aa112f14d5068"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-isoleucine biosynthesis I (from threonine) pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ILEUSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-034_179635d431ef	RHEA:27695	pathwaymech:precedes	RHEA:24803	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ILEUSYN-PWY		"[{""reference_id"": ""MetaCyc:ILEUSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:27695 before RHEA:24803 in this pathway. Shared intermediate: CHEBI:35146."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ILEUSYN-PWY"", ""source_sha256"": ""244072bf8d255c78be815aec586397fd6031dd3b78cc05a2db8aa112f14d5068"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-isoleucine biosynthesis I (from threonine) pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ILEUSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-035_e19658976a93	RHEA:39968	pathwaymech:precedes	RHEA:39976	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ILEUSYN-PWY		"[{""reference_id"": ""MetaCyc:ILEUSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:39968 before RHEA:39976 in this pathway. Shared intermediate: CHEBI:76545."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ILEUSYN-PWY"", ""source_sha256"": ""244072bf8d255c78be815aec586397fd6031dd3b78cc05a2db8aa112f14d5068"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-isoleucine biosynthesis I (from threonine) pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ILEUSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-036_ad15fc5fc12e	RHEA:39976	pathwaymech:precedes	RHEA:27655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ILEUSYN-PWY		"[{""reference_id"": ""MetaCyc:ILEUSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:39976 before RHEA:27655 in this pathway. Shared intermediate: CHEBI:16763."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ILEUSYN-PWY"", ""source_sha256"": ""244072bf8d255c78be815aec586397fd6031dd3b78cc05a2db8aa112f14d5068"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-isoleucine biosynthesis I (from threonine) pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ILEUSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-037_e72a8497dad1	RHEA:40676	pathwaymech:precedes	RHEA:39968	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ILEUSYN-PWY		"[{""reference_id"": ""MetaCyc:ILEUSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:40676 before RHEA:39968 in this pathway. Shared intermediate: CHEBI:48306."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:ILEUSYN-PWY"", ""source_sha256"": ""244072bf8d255c78be815aec586397fd6031dd3b78cc05a2db8aa112f14d5068"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-isoleucine biosynthesis I (from threonine) pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:ILEUSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-038_0a0ac1f7d73c	UniProtKB:P00893	pathwaymech:enables	RHEA:27655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:2675968		"[{""reference_id"": ""PMID:2675968"", ""source_assertion"": ""The study directly measures E. coli acetohydroxy acid synthase III producing acetohydroxybutyrate from pyruvate and 2-ketobutyrate; UniProt identifies its catalytic subunit as P00893."", ""source_locator"": ""PubMed Abstract; AHAS isozyme III kinetics; UniProt proteinDescription and genes""}]"	"[{""citation"": ""Gollop et al., Biochemistry, 1989"", ""id"": ""PMID:2675968"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/2675968/""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-039_b337da328cbc	CHEBI:57762	pathwaymech:inhibits	UniProtKB:P00893	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00893		"[{""reference_id"": ""UniProtKB:P00893"", ""source_assertion"": ""UniProt activity-regulation annotation: Sensitive to valine inhibition"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P00893"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00893 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00893.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-040_d9a70fa2b42a	UniProtKB:P00893	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00893		"[{""reference_id"": ""UniProtKB:P00893"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P00893 (evidence: ECO:0000250). Binds 1 Mg(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P00893"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00893 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00893.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-041_33d56f7e3086	UniProtKB:P00893	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00893		"[{""reference_id"": ""UniProtKB:P00893"", ""source_assertion"": ""UniProt lists CHEBI:58937 as a cofactor of UniProtKB:P00893 (evidence: ECO:0000250). Binds 1 thiamine pyrophosphate per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P00893"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00893 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00893.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-042_aff9747d2104	UniProtKB:P04968	pathwaymech:enables	RHEA:40676	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P04968		"[{""reference_id"": ""UniProtKB:P04968"", ""source_assertion"": ""UniProt annotates UniProtKB:P04968 with catalytic activity for the overall reaction containing the native MetaCyc enzymatic component RHEA:40676. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P04968"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P04968 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P04968.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-043_f6743ec07505	CHEBI:58045	pathwaymech:inhibits	UniProtKB:P04968	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P04968		"[{""reference_id"": ""UniProtKB:P04968"", ""source_assertion"": ""UniProt activity-regulation annotation: Isoleucine allosterically inhibits whereas valine allosterically activates this enzyme"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P04968"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P04968 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P04968.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-044_9b3532ce1e56	CHEBI:57762	pathwaymech:activates	UniProtKB:P04968	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P04968		"[{""reference_id"": ""UniProtKB:P04968"", ""source_assertion"": ""UniProt activity-regulation annotation: Isoleucine allosterically inhibits whereas valine allosterically activates this enzyme"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P04968"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P04968 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P04968.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-045_79a876acb6c5	UniProtKB:P04968	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P04968		"[{""reference_id"": ""UniProtKB:P04968"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P04968 (evidence: ECO:0000269). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P04968"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P04968 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P04968.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-046_59952c3a2c07	UniProtKB:P05791	pathwaymech:enables	RHEA:27695	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05791		"[{""reference_id"": ""UniProtKB:P05791"", ""source_assertion"": ""UniProt annotates UniProtKB:P05791 with catalytic activity for the reaction family of RHEA:27695. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P05791"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05791 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05791.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-047_776caf13ded4	UniProtKB:P05791	pathwaymech:has_cofactor	CHEBI:30408	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05791		"[{""reference_id"": ""UniProtKB:P05791"", ""source_assertion"": ""UniProt lists CHEBI:30408 as a cofactor of UniProtKB:P05791 (evidence: ECO:0000255). Cluster nuclearity is left unspecified: the current UniProt annotation infers [2Fe-2S], while its caution cites older E. coli [4Fe-4S] evidence and a later M. tuberculosis result."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P05791"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05791 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05791.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-048_0808780a596e	UniProtKB:P05791	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05791		"[{""reference_id"": ""UniProtKB:P05791"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P05791 (evidence: ECO:0000255). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P05791"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05791 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05791.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-049_1fb860df4ad4	UniProtKB:P05793	pathwaymech:enables	RHEA:13495	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05793		"[{""reference_id"": ""UniProtKB:P05793"", ""source_assertion"": ""UniProt annotates UniProtKB:P05793 with catalytic activity for the reaction family of RHEA:13495. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P05793"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05793 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05793.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-050_6163e16634ea	UniProtKB:P05793	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05793		"[{""reference_id"": ""UniProtKB:P05793"", ""source_assertion"": ""UniProt locates UniProtKB:P05793 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P05793"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05793 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05793.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-051_67a517a430ce	UniProtKB:P05793	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05793		"[{""reference_id"": ""UniProtKB:P05793"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P05793 (evidence: ECO:0000255, ECO:0000269). Binds 2 magnesium ions per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P05793"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05793 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05793.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-052_68cadf617ab9	UniProtKB:P0AB80	pathwaymech:enables	RHEA:24803	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AB80		"[{""reference_id"": ""UniProtKB:P0AB80"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AB80 with catalytic activity for the reaction family of RHEA:24803. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AB80"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AB80 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AB80.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-053_433ec33b8823	UniProtKB:P0AB80	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AB80		"[{""reference_id"": ""UniProtKB:P0AB80"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P0AB80 (evidence: curated annotation). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AB80"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AB80 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AB80.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-054_a037e5cac11c	UniProtKB:P0AF93	pathwaymech:enables	RHEA:39976	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF93		"[{""reference_id"": ""UniProtKB:P0AF93"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AF93 with catalytic activity for the reaction family of RHEA:39976. Annotation evidence: ECO:0000250; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AF93"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AF93 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF93.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-055_fa4707e955d3	UniProtKB:P0AF93	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF93		"[{""reference_id"": ""UniProtKB:P0AF93"", ""source_assertion"": ""UniProt locates UniProtKB:P0AF93 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0AF93"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AF93 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF93.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-056_351bf5bd9d03	UniProtKB:P0AGF6	pathwaymech:enables	RHEA:40676	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AGF6		"[{""reference_id"": ""UniProtKB:P0AGF6"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AGF6 with catalytic activity for the overall reaction containing the native MetaCyc enzymatic component RHEA:40676. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AGF6"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AGF6 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AGF6.json""}]"	""
pathwaymech:MetaCyc_ILEUSYN-PWY_edge-057_e91e8dee7324	UniProtKB:P0AGF6	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AGF6		"[{""reference_id"": ""UniProtKB:P0AGF6"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P0AGF6 (evidence: ECO:0000269). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AGF6"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AGF6 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AGF6.json""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-001_1a03e4fafb5a	CHEBI:11851	pathwaymech:consumes	RHEA:21525	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21525		"[{""reference_id"": ""RHEA:21525"", ""source_assertion"": ""Rhea lists CHEBI:11851 on the substrates side of RHEA:21525 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21525']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21525"", ""source_version"": ""139"", ""title"": ""Rhea 2-isopropylmalate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/21525""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-002_cedec0fc9d9f	CHEBI:15377	pathwaymech:consumes	RHEA:21525	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21525		"[{""reference_id"": ""RHEA:21525"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:21525 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21525']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21525"", ""source_version"": ""139"", ""title"": ""Rhea 2-isopropylmalate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/21525""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-003_89097a061a5a	CHEBI:57288	pathwaymech:consumes	RHEA:21525	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21525		"[{""reference_id"": ""RHEA:21525"", ""source_assertion"": ""Rhea lists CHEBI:57288 on the substrates side of RHEA:21525 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21525']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21525"", ""source_version"": ""139"", ""title"": ""Rhea 2-isopropylmalate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/21525""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-004_e6c5bd520161	RHEA:21525	pathwaymech:produces	CHEBI:1178	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21525		"[{""reference_id"": ""RHEA:21525"", ""source_assertion"": ""Rhea lists CHEBI:1178 on the products side of RHEA:21525 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21525']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21525"", ""source_version"": ""139"", ""title"": ""Rhea 2-isopropylmalate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/21525""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-005_dfdc257c8b67	RHEA:21525	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21525		"[{""reference_id"": ""RHEA:21525"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:21525 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21525']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21525"", ""source_version"": ""139"", ""title"": ""Rhea 2-isopropylmalate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/21525""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-006_fd7cd100a572	RHEA:21525	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21525		"[{""reference_id"": ""RHEA:21525"", ""source_assertion"": ""Rhea lists CHEBI:57287 on the products side of RHEA:21525 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21525']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21525"", ""source_version"": ""139"", ""title"": ""Rhea 2-isopropylmalate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/21525""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-007_b2e39fc64456	CHEBI:17865	pathwaymech:consumes	RHEA:18323	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18323		"[{""reference_id"": ""RHEA:18323"", ""source_assertion"": ""Rhea lists CHEBI:17865 on the substrates side of RHEA:18323 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18323']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18323"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic L-leucine transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/18323""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-008_437548c91bb4	CHEBI:29985	pathwaymech:consumes	RHEA:18323	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18323		"[{""reference_id"": ""RHEA:18323"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the substrates side of RHEA:18323 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18323']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18323"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic L-leucine transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/18323""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-009_eca7974d1ec8	RHEA:18323	pathwaymech:produces	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18323		"[{""reference_id"": ""RHEA:18323"", ""source_assertion"": ""Rhea lists CHEBI:16810 on the products side of RHEA:18323 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18323']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18323"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic L-leucine transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/18323""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-010_fb13800b9652	RHEA:18323	pathwaymech:produces	CHEBI:57427	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18323		"[{""reference_id"": ""RHEA:18323"", ""source_assertion"": ""Rhea lists CHEBI:57427 on the products side of RHEA:18323 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18323']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18323"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic L-leucine transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/18323""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-011_8f6ff2ae5da5	CHEBI:1178	pathwaymech:consumes	RHEA:16295	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16295		"[{""reference_id"": ""RHEA:16295"", ""source_assertion"": ""Rhea lists CHEBI:1178 on the substrates side of RHEA:16295 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16295']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16295"", ""source_version"": ""139"", ""title"": ""RHEA:16295 authority record"", ""url"": ""https://www.rhea-db.org/rhea/16295""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-012_7b3a74b1cf23	RHEA:16295	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16295		"[{""reference_id"": ""RHEA:16295"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:16295 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16295']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16295"", ""source_version"": ""139"", ""title"": ""RHEA:16295 authority record"", ""url"": ""https://www.rhea-db.org/rhea/16295""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-013_4ac64b1e7475	RHEA:16295	pathwaymech:produces	CHEBI:58085	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16295		"[{""reference_id"": ""RHEA:16295"", ""source_assertion"": ""Rhea lists CHEBI:58085 on the products side of RHEA:16295 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16295']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16295"", ""source_version"": ""139"", ""title"": ""RHEA:16295 authority record"", ""url"": ""https://www.rhea-db.org/rhea/16295""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-014_ae9b4e4758c1	CHEBI:15377	pathwaymech:consumes	RHEA:10678	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10678		"[{""reference_id"": ""RHEA:10678"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:10678 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10678']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10678"", ""source_version"": ""139"", ""title"": ""RHEA:10678 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10678""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-015_4074bb80f0fe	CHEBI:58085	pathwaymech:consumes	RHEA:10678	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10678		"[{""reference_id"": ""RHEA:10678"", ""source_assertion"": ""Rhea lists CHEBI:58085 on the substrates side of RHEA:10678 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10678']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10678"", ""source_version"": ""139"", ""title"": ""RHEA:10678 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10678""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-016_308403ca0125	RHEA:10678	pathwaymech:produces	CHEBI:35121	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10678		"[{""reference_id"": ""RHEA:10678"", ""source_assertion"": ""Rhea lists CHEBI:35121 on the products side of RHEA:10678 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10678']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10678"", ""source_version"": ""139"", ""title"": ""RHEA:10678 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10678""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-017_8ee865d53355	CHEBI:35121	pathwaymech:consumes	RHEA:10893	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10893		"[{""reference_id"": ""RHEA:10893"", ""source_assertion"": ""Rhea lists CHEBI:35121 on the substrates side of RHEA:10893 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10893']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10893"", ""source_version"": ""139"", ""title"": ""RHEA:10893 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10893""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-018_4911c7acac49	CHEBI:57540	pathwaymech:consumes	RHEA:10893	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10893		"[{""reference_id"": ""RHEA:10893"", ""source_assertion"": ""Rhea lists CHEBI:57540 on the substrates side of RHEA:10893 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10893']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10893"", ""source_version"": ""139"", ""title"": ""RHEA:10893 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10893""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-019_3b908d869bf3	RHEA:10893	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10893		"[{""reference_id"": ""RHEA:10893"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:10893 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10893']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10893"", ""source_version"": ""139"", ""title"": ""RHEA:10893 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10893""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-020_4b9473fe61c3	RHEA:10893	pathwaymech:produces	CHEBI:17214	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10893		"[{""reference_id"": ""RHEA:10893"", ""source_assertion"": ""Rhea lists CHEBI:17214 on the products side of RHEA:10893 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10893']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10893"", ""source_version"": ""139"", ""title"": ""RHEA:10893 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10893""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-021_5a6021621d1b	RHEA:10893	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10893		"[{""reference_id"": ""RHEA:10893"", ""source_assertion"": ""Rhea lists CHEBI:57945 on the products side of RHEA:10893 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10893']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10893"", ""source_version"": ""139"", ""title"": ""RHEA:10893 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10893""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-022_cce1b71c41ee	CHEBI:15378	pathwaymech:consumes	RHEA:25079	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25079		"[{""reference_id"": ""RHEA:25079"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:25079 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25079']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25079"", ""source_version"": ""139"", ""title"": ""RHEA:25079 authority record"", ""url"": ""https://www.rhea-db.org/rhea/25079""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-023_779aeaa6e885	CHEBI:17214	pathwaymech:consumes	RHEA:25079	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25079		"[{""reference_id"": ""RHEA:25079"", ""source_assertion"": ""Rhea lists CHEBI:17214 on the substrates side of RHEA:25079 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25079']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25079"", ""source_version"": ""139"", ""title"": ""RHEA:25079 authority record"", ""url"": ""https://www.rhea-db.org/rhea/25079""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-024_bd6054b29616	RHEA:25079	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25079		"[{""reference_id"": ""RHEA:25079"", ""source_assertion"": ""Rhea lists CHEBI:16526 on the products side of RHEA:25079 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25079']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25079"", ""source_version"": ""139"", ""title"": ""RHEA:25079 authority record"", ""url"": ""https://www.rhea-db.org/rhea/25079""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-025_9ebd7a9dbf7b	RHEA:25079	pathwaymech:produces	CHEBI:17865	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25079		"[{""reference_id"": ""RHEA:25079"", ""source_assertion"": ""Rhea lists CHEBI:17865 on the products side of RHEA:25079 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25079']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25079"", ""source_version"": ""139"", ""title"": ""RHEA:25079 authority record"", ""url"": ""https://www.rhea-db.org/rhea/25079""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-026_a5243aee5db6	EC:2.3.3.13	pathwaymech:catalyzes	RHEA:21525	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21524		"[{""reference_id"": ""RHEA:21524"", ""source_assertion"": ""Rhea associates EC:2.3.3.13 with the reaction family containing RHEA:21525."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:21524"", ""source_version"": ""139"", ""title"": ""Rhea 2-isopropylmalate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/21524""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-027_566be0991d19	EC:4.2.1.33	pathwaymech:catalyzes	RHEA:16295	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:LEUSYN-PWY|PMID:14087357		"[{""reference_id"": ""MetaCyc:LEUSYN-PWY"", ""source_assertion"": ""The native pathway assigns EC:4.2.1.33 activity to the enzymatic step represented by RHEA:16295; this is a component step when the EC definition is an overall reaction."", ""source_locator"": ""Pathway/reaction-layout; Reaction/enzymatic-reaction and component-reaction relationships""}, {""quote"": ""The biosynthesis of leucine. II. The enzymic isomerization of beta-carboxy-beta-hydroxyisocaproate and alpha-hydroxy-beta-carboxyisocaproate."", ""reference_id"": ""PMID:14087357"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""id"": ""MetaCyc:LEUSYN-PWY"", ""source_sha256"": ""899e2879cc0df365db296bef0e6def77132a41c9bfdbb32d266665d4a00ac934"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-leucine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:LEUSYN-PWY&detail=full""}, {""citation"": ""Gross et al., Biochemistry, 1963"", ""id"": ""PMID:14087357"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/14087357/""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-028_c4c7251fef3e	EC:4.2.1.33	pathwaymech:catalyzes	RHEA:10678	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:LEUSYN-PWY|PMID:14087357		"[{""reference_id"": ""MetaCyc:LEUSYN-PWY"", ""source_assertion"": ""The native pathway assigns EC:4.2.1.33 activity to the enzymatic step represented by RHEA:10678; this is a component step when the EC definition is an overall reaction."", ""source_locator"": ""Pathway/reaction-layout; Reaction/enzymatic-reaction and component-reaction relationships""}, {""quote"": ""The biosynthesis of leucine. II. The enzymic isomerization of beta-carboxy-beta-hydroxyisocaproate and alpha-hydroxy-beta-carboxyisocaproate."", ""reference_id"": ""PMID:14087357"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""id"": ""MetaCyc:LEUSYN-PWY"", ""source_sha256"": ""899e2879cc0df365db296bef0e6def77132a41c9bfdbb32d266665d4a00ac934"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-leucine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:LEUSYN-PWY&detail=full""}, {""citation"": ""Gross et al., Biochemistry, 1963"", ""id"": ""PMID:14087357"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/14087357/""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-029_4837c5eef872	EC:1.1.1.85	pathwaymech:catalyzes	RHEA:10893	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:LEUSYN-PWY|PMID:14087358		"[{""reference_id"": ""MetaCyc:LEUSYN-PWY"", ""source_assertion"": ""The native pathway assigns EC:1.1.1.85 activity to the enzymatic step represented by RHEA:10893; this is a component step when the EC definition is an overall reaction."", ""source_locator"": ""Pathway/reaction-layout; Reaction/enzymatic-reaction and component-reaction relationships""}, {""quote"": ""The biosynthesis of leucine. III. The conversion of alpha-hydroxy-beta-carboxyisocaproate to alpha-ketoisocaproate."", ""reference_id"": ""PMID:14087358"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""id"": ""MetaCyc:LEUSYN-PWY"", ""source_sha256"": ""899e2879cc0df365db296bef0e6def77132a41c9bfdbb32d266665d4a00ac934"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-leucine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:LEUSYN-PWY&detail=full""}, {""citation"": ""Burns et al., Biochemistry, 1963"", ""id"": ""PMID:14087358"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/14087358/""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-030_ce2da095ae1c	EC:2.6.1.42	pathwaymech:catalyzes	RHEA:18323	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:378964|RHEA:18321		"[{""reference_id"": ""RHEA:18321"", ""source_assertion"": ""Rhea associates EC:2.6.1.42 with the reaction family containing RHEA:18323."", ""source_locator"": ""rh:ec""}, {""quote"": ""Transaminase B from Escherichia coli: quaternary structure, amino-terminal sequence, substrate specificity, and absence of a separate valine-alpha-ketoglutarate activity."", ""reference_id"": ""PMID:378964"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Lee-Peng et al., Journal of Bacteriology, 1979"", ""id"": ""PMID:378964"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/378964/""}, {""id"": ""RHEA:18321"", ""source_version"": ""139"", ""title"": ""Rhea L-leucine transaminase reaction"", ""url"": ""https://www.rhea-db.org/rhea/18321""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-031_93bd1d34e50b	RHEA:10678	pathwaymech:precedes	RHEA:10893	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:LEUSYN-PWY		"[{""reference_id"": ""MetaCyc:LEUSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:10678 before RHEA:10893 in this pathway. Shared intermediate: CHEBI:35121."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:LEUSYN-PWY"", ""source_sha256"": ""899e2879cc0df365db296bef0e6def77132a41c9bfdbb32d266665d4a00ac934"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-leucine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:LEUSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-032_c0d153530057	RHEA:10893	pathwaymech:precedes	RHEA:25079	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:LEUSYN-PWY		"[{""reference_id"": ""MetaCyc:LEUSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:10893 before RHEA:25079 in this pathway. Shared intermediate: CHEBI:17214."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:LEUSYN-PWY"", ""source_sha256"": ""899e2879cc0df365db296bef0e6def77132a41c9bfdbb32d266665d4a00ac934"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-leucine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:LEUSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-033_51c65f1f0770	RHEA:16295	pathwaymech:precedes	RHEA:10678	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:LEUSYN-PWY		"[{""reference_id"": ""MetaCyc:LEUSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:16295 before RHEA:10678 in this pathway. Shared intermediate: CHEBI:58085."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:LEUSYN-PWY"", ""source_sha256"": ""899e2879cc0df365db296bef0e6def77132a41c9bfdbb32d266665d4a00ac934"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-leucine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:LEUSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-034_be65c3be596c	RHEA:21525	pathwaymech:precedes	RHEA:16295	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:LEUSYN-PWY		"[{""reference_id"": ""MetaCyc:LEUSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:21525 before RHEA:16295 in this pathway. Shared intermediate: CHEBI:1178."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:LEUSYN-PWY"", ""source_sha256"": ""899e2879cc0df365db296bef0e6def77132a41c9bfdbb32d266665d4a00ac934"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-leucine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:LEUSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-035_731f6b128fe4	RHEA:25079	pathwaymech:precedes	RHEA:18323	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:LEUSYN-PWY		"[{""reference_id"": ""MetaCyc:LEUSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:25079 before RHEA:18323 in this pathway. Shared intermediate: CHEBI:17865."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:LEUSYN-PWY"", ""source_sha256"": ""899e2879cc0df365db296bef0e6def77132a41c9bfdbb32d266665d4a00ac934"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-leucine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:LEUSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-036_159c84caac9f	UniProtKB:P09151	pathwaymech:enables	RHEA:21525	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09151		"[{""reference_id"": ""UniProtKB:P09151"", ""source_assertion"": ""UniProt annotates UniProtKB:P09151 with catalytic activity for the reaction family of RHEA:21525. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P09151"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P09151 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P09151.json""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-037_62ef38afe060	UniProtKB:P09151	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09151		"[{""reference_id"": ""UniProtKB:P09151"", ""source_assertion"": ""UniProt locates UniProtKB:P09151 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P09151"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P09151 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P09151.json""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-038_887ce09adaf9	UniProtKB:P09151	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09151		"[{""reference_id"": ""UniProtKB:P09151"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P09151 (evidence: ECO:0000255). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P09151"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P09151 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P09151.json""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-039_94c6daaff113	UniProtKB:P0A6A6	pathwaymech:enables	RHEA:16295	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6A6		"[{""reference_id"": ""UniProtKB:P0A6A6"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A6A6 with catalytic activity for the overall reaction containing the native MetaCyc enzymatic component RHEA:16295. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A6A6"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6A6 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6A6.json""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-040_301f43ea1efd	UniProtKB:P0A6A6	pathwaymech:enables	RHEA:10678	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6A6		"[{""reference_id"": ""UniProtKB:P0A6A6"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A6A6 with catalytic activity for the overall reaction containing the native MetaCyc enzymatic component RHEA:10678. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A6A6"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6A6 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6A6.json""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-041_e33583d762bc	UniProtKB:P0A6A6	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6A6		"[{""reference_id"": ""UniProtKB:P0A6A6"", ""source_assertion"": ""UniProt lists CHEBI:49883 as a cofactor of UniProtKB:P0A6A6 (evidence: ECO:0000255). Binds 1 [4Fe-4S] cluster per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0A6A6"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6A6 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6A6.json""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-042_c724b1a71837	UniProtKB:P0AB80	pathwaymech:enables	RHEA:18323	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AB80		"[{""reference_id"": ""UniProtKB:P0AB80"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AB80 with catalytic activity for the reaction family of RHEA:18323. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AB80"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AB80 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AB80.json""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-043_00533d5f8eb7	UniProtKB:P0AB80	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AB80		"[{""reference_id"": ""UniProtKB:P0AB80"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P0AB80 (evidence: curated annotation). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AB80"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AB80 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AB80.json""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-044_625ffc3770ec	UniProtKB:P30125	pathwaymech:enables	RHEA:10893	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P30125		"[{""reference_id"": ""UniProtKB:P30125"", ""source_assertion"": ""UniProt annotates UniProtKB:P30125 with catalytic activity for the overall reaction containing the native MetaCyc enzymatic component RHEA:10893. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P30125"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P30125 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30125.json""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-045_39c91909cf40	UniProtKB:P30125	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P30125		"[{""reference_id"": ""UniProtKB:P30125"", ""source_assertion"": ""UniProt locates UniProtKB:P30125 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P30125"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P30125 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30125.json""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-046_01c44d87ee1d	UniProtKB:P30125	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P30125		"[{""reference_id"": ""UniProtKB:P30125"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P30125 (evidence: ECO:0000255, ECO:0000269). Binds 1 Mg(2+) or Mn(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P30125"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P30125 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30125.json""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-047_e5f744500a1f	UniProtKB:P30125	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P30125		"[{""reference_id"": ""UniProtKB:P30125"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P30125 (evidence: ECO:0000255, ECO:0000269). Binds 1 Mg(2+) or Mn(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P30125"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P30125 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30125.json""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-048_2f344232f423	UniProtKB:P30126	pathwaymech:enables	RHEA:16295	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P30126		"[{""reference_id"": ""UniProtKB:P30126"", ""source_assertion"": ""UniProt annotates UniProtKB:P30126 with catalytic activity for the overall reaction containing the native MetaCyc enzymatic component RHEA:16295. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P30126"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P30126 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30126.json""}]"	""
pathwaymech:MetaCyc_LEUSYN-PWY_edge-049_381563e95245	UniProtKB:P30126	pathwaymech:enables	RHEA:10678	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P30126		"[{""reference_id"": ""UniProtKB:P30126"", ""source_assertion"": ""UniProt annotates UniProtKB:P30126 with catalytic activity for the overall reaction containing the native MetaCyc enzymatic component RHEA:10678. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P30126"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P30126 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30126.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-001_80692808d9af	CHEBI:29991	pathwaymech:consumes	RHEA:23777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23777		"[{""reference_id"": ""RHEA:23777"", ""source_assertion"": ""Rhea lists CHEBI:29991 on the substrates side of RHEA:23777 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23777']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23777"", ""source_version"": ""139"", ""title"": ""Rhea L-aspartyl-4-phosphate-forming aspartate kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/23777""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-002_9b6504b43025	CHEBI:30616	pathwaymech:consumes	RHEA:23777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23777		"[{""reference_id"": ""RHEA:23777"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:23777 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23777']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23777"", ""source_version"": ""139"", ""title"": ""Rhea L-aspartyl-4-phosphate-forming aspartate kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/23777""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-003_fee86954a075	RHEA:23777	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23777		"[{""reference_id"": ""RHEA:23777"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:23777 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23777']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23777"", ""source_version"": ""139"", ""title"": ""Rhea L-aspartyl-4-phosphate-forming aspartate kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/23777""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-004_852bb309d032	RHEA:23777	pathwaymech:produces	CHEBI:57535	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23777		"[{""reference_id"": ""RHEA:23777"", ""source_assertion"": ""Rhea lists CHEBI:57535 on the products side of RHEA:23777 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23777']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23777"", ""source_version"": ""139"", ""title"": ""Rhea L-aspartyl-4-phosphate-forming aspartate kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/23777""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-005_40cad0b41fea	CHEBI:15378	pathwaymech:consumes	RHEA:24286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24286		"[{""reference_id"": ""RHEA:24286"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:24286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24286']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24286"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic aspartate-semialdehyde dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/24286""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-006_de4e81b6aa6b	CHEBI:57535	pathwaymech:consumes	RHEA:24286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24286		"[{""reference_id"": ""RHEA:24286"", ""source_assertion"": ""Rhea lists CHEBI:57535 on the substrates side of RHEA:24286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24286']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24286"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic aspartate-semialdehyde dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/24286""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-007_9290d64274d8	CHEBI:57783	pathwaymech:consumes	RHEA:24286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24286		"[{""reference_id"": ""RHEA:24286"", ""source_assertion"": ""Rhea lists CHEBI:57783 on the substrates side of RHEA:24286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24286']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24286"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic aspartate-semialdehyde dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/24286""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-008_9a355d481395	RHEA:24286	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24286		"[{""reference_id"": ""RHEA:24286"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:24286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24286']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24286"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic aspartate-semialdehyde dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/24286""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-009_1ec0a1bffb73	RHEA:24286	pathwaymech:produces	CHEBI:537519	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24286		"[{""reference_id"": ""RHEA:24286"", ""source_assertion"": ""Rhea lists CHEBI:537519 on the products side of RHEA:24286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24286']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24286"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic aspartate-semialdehyde dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/24286""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-010_c1b83459e621	RHEA:24286	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24286		"[{""reference_id"": ""RHEA:24286"", ""source_assertion"": ""Rhea lists CHEBI:58349 on the products side of RHEA:24286 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24286']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24286"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic aspartate-semialdehyde dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/24286""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-011_de476885145a	CHEBI:15361	pathwaymech:consumes	RHEA:34172	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34172		"[{""reference_id"": ""RHEA:34172"", ""source_assertion"": ""Rhea lists CHEBI:15361 on the substrates side of RHEA:34172 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34172']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:34172"", ""source_version"": ""139"", ""title"": ""Rhea 4-hydroxy-tetrahydrodipicolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/34172""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-012_ece5aadbeba1	CHEBI:537519	pathwaymech:consumes	RHEA:34172	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34172		"[{""reference_id"": ""RHEA:34172"", ""source_assertion"": ""Rhea lists CHEBI:537519 on the substrates side of RHEA:34172 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34172']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:34172"", ""source_version"": ""139"", ""title"": ""Rhea 4-hydroxy-tetrahydrodipicolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/34172""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-013_d98f11d92548	RHEA:34172	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34172		"[{""reference_id"": ""RHEA:34172"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:34172 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34172']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:34172"", ""source_version"": ""139"", ""title"": ""Rhea 4-hydroxy-tetrahydrodipicolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/34172""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-014_627f9f8fc258	RHEA:34172	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34172		"[{""reference_id"": ""RHEA:34172"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:34172 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34172']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:34172"", ""source_version"": ""139"", ""title"": ""Rhea 4-hydroxy-tetrahydrodipicolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/34172""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-015_b89095563b6b	RHEA:34172	pathwaymech:produces	CHEBI:67139	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34172		"[{""reference_id"": ""RHEA:34172"", ""source_assertion"": ""Rhea lists CHEBI:67139 on the products side of RHEA:34172 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34172']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:34172"", ""source_version"": ""139"", ""title"": ""Rhea 4-hydroxy-tetrahydrodipicolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/34172""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-016_c7326a190990	CHEBI:15378	pathwaymech:consumes	RHEA:35325	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35325		"[{""reference_id"": ""RHEA:35325"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:35325 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/35325']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:35325"", ""source_version"": ""139"", ""title"": ""Rhea NADH-dependent tetrahydrodipicolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/35325""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-017_bacd7830f1ed	CHEBI:57945	pathwaymech:consumes	RHEA:35325	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35325		"[{""reference_id"": ""RHEA:35325"", ""source_assertion"": ""Rhea lists CHEBI:57945 on the substrates side of RHEA:35325 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/35325']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:35325"", ""source_version"": ""139"", ""title"": ""Rhea NADH-dependent tetrahydrodipicolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/35325""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-018_15a3bc9b5877	CHEBI:67139	pathwaymech:consumes	RHEA:35325	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35325		"[{""reference_id"": ""RHEA:35325"", ""source_assertion"": ""Rhea lists CHEBI:67139 on the substrates side of RHEA:35325 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/35325']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:35325"", ""source_version"": ""139"", ""title"": ""Rhea NADH-dependent tetrahydrodipicolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/35325""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-019_6da0df276343	RHEA:35325	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35325		"[{""reference_id"": ""RHEA:35325"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:35325 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/35325']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:35325"", ""source_version"": ""139"", ""title"": ""Rhea NADH-dependent tetrahydrodipicolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/35325""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-020_11e5ae1a2f23	RHEA:35325	pathwaymech:produces	CHEBI:16845	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35325		"[{""reference_id"": ""RHEA:35325"", ""source_assertion"": ""Rhea lists CHEBI:16845 on the products side of RHEA:35325 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/35325']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:35325"", ""source_version"": ""139"", ""title"": ""Rhea NADH-dependent tetrahydrodipicolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/35325""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-021_b6952613ed59	RHEA:35325	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35325		"[{""reference_id"": ""RHEA:35325"", ""source_assertion"": ""Rhea lists CHEBI:57540 on the products side of RHEA:35325 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/35325']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:35325"", ""source_version"": ""139"", ""title"": ""Rhea NADH-dependent tetrahydrodipicolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/35325""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-022_ed1818e3c464	CHEBI:15378	pathwaymech:consumes	RHEA:35333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35333		"[{""reference_id"": ""RHEA:35333"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:35333 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/35333']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:35333"", ""source_version"": ""139"", ""title"": ""Rhea NADPH-dependent tetrahydrodipicolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/35333""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-023_faf18653a2a1	CHEBI:57783	pathwaymech:consumes	RHEA:35333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35333		"[{""reference_id"": ""RHEA:35333"", ""source_assertion"": ""Rhea lists CHEBI:57783 on the substrates side of RHEA:35333 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/35333']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:35333"", ""source_version"": ""139"", ""title"": ""Rhea NADPH-dependent tetrahydrodipicolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/35333""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-024_78607f9d0105	CHEBI:67139	pathwaymech:consumes	RHEA:35333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35333		"[{""reference_id"": ""RHEA:35333"", ""source_assertion"": ""Rhea lists CHEBI:67139 on the substrates side of RHEA:35333 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/35333']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:35333"", ""source_version"": ""139"", ""title"": ""Rhea NADPH-dependent tetrahydrodipicolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/35333""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-025_ef0d8a00a8d2	RHEA:35333	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35333		"[{""reference_id"": ""RHEA:35333"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:35333 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/35333']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:35333"", ""source_version"": ""139"", ""title"": ""Rhea NADPH-dependent tetrahydrodipicolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/35333""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-026_f7c7e481caf4	RHEA:35333	pathwaymech:produces	CHEBI:16845	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35333		"[{""reference_id"": ""RHEA:35333"", ""source_assertion"": ""Rhea lists CHEBI:16845 on the products side of RHEA:35333 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/35333']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:35333"", ""source_version"": ""139"", ""title"": ""Rhea NADPH-dependent tetrahydrodipicolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/35333""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-027_f0861eff0d62	RHEA:35333	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35333		"[{""reference_id"": ""RHEA:35333"", ""source_assertion"": ""Rhea lists CHEBI:58349 on the products side of RHEA:35333 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/35333']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:35333"", ""source_version"": ""139"", ""title"": ""Rhea NADPH-dependent tetrahydrodipicolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/35333""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-028_740a83c0339c	CHEBI:15377	pathwaymech:consumes	RHEA:17326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17326		"[{""reference_id"": ""RHEA:17326"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:17326 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17326']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17326"", ""source_version"": ""139"", ""title"": ""Rhea N-succinylamino-6-oxoheptanedioate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17326""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-029_b9f212f4aceb	CHEBI:16845	pathwaymech:consumes	RHEA:17326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17326		"[{""reference_id"": ""RHEA:17326"", ""source_assertion"": ""Rhea lists CHEBI:16845 on the substrates side of RHEA:17326 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17326']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17326"", ""source_version"": ""139"", ""title"": ""Rhea N-succinylamino-6-oxoheptanedioate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17326""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-030_10777787620c	CHEBI:57292	pathwaymech:consumes	RHEA:17326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17326		"[{""reference_id"": ""RHEA:17326"", ""source_assertion"": ""Rhea lists CHEBI:57292 on the substrates side of RHEA:17326 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17326']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17326"", ""source_version"": ""139"", ""title"": ""Rhea N-succinylamino-6-oxoheptanedioate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17326""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-031_157e5531799a	RHEA:17326	pathwaymech:produces	CHEBI:15685	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17326		"[{""reference_id"": ""RHEA:17326"", ""source_assertion"": ""Rhea lists CHEBI:15685 on the products side of RHEA:17326 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17326']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17326"", ""source_version"": ""139"", ""title"": ""Rhea N-succinylamino-6-oxoheptanedioate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17326""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-032_9bd63cc28c67	RHEA:17326	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17326		"[{""reference_id"": ""RHEA:17326"", ""source_assertion"": ""Rhea lists CHEBI:57287 on the products side of RHEA:17326 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17326']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17326"", ""source_version"": ""139"", ""title"": ""Rhea N-succinylamino-6-oxoheptanedioate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/17326""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-033_8b9b29ae3366	CHEBI:15685	pathwaymech:consumes	RHEA:11962	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11962		"[{""reference_id"": ""RHEA:11962"", ""source_assertion"": ""Rhea lists CHEBI:15685 on the substrates side of RHEA:11962 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11962']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11962"", ""source_version"": ""139"", ""title"": ""Rhea N-succinyldiaminopimelate-forming transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/11962""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-034_c706c9c55644	CHEBI:29985	pathwaymech:consumes	RHEA:11962	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11962		"[{""reference_id"": ""RHEA:11962"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the substrates side of RHEA:11962 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11962']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11962"", ""source_version"": ""139"", ""title"": ""Rhea N-succinyldiaminopimelate-forming transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/11962""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-035_87557f746c33	RHEA:11962	pathwaymech:produces	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11962		"[{""reference_id"": ""RHEA:11962"", ""source_assertion"": ""Rhea lists CHEBI:16810 on the products side of RHEA:11962 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11962']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11962"", ""source_version"": ""139"", ""title"": ""Rhea N-succinyldiaminopimelate-forming transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/11962""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-036_7742df9a7b63	RHEA:11962	pathwaymech:produces	CHEBI:58087	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11962		"[{""reference_id"": ""RHEA:11962"", ""source_assertion"": ""Rhea lists CHEBI:58087 on the products side of RHEA:11962 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11962']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11962"", ""source_version"": ""139"", ""title"": ""Rhea N-succinyldiaminopimelate-forming transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/11962""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-037_41a8da55a041	CHEBI:15377	pathwaymech:consumes	RHEA:22609	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22609		"[{""reference_id"": ""RHEA:22609"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:22609 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22609']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22609"", ""source_version"": ""139"", ""title"": ""Rhea L,L-diaminopimelate-forming desuccinylase direction"", ""url"": ""https://www.rhea-db.org/rhea/22609""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-038_b9fde3a67d78	CHEBI:58087	pathwaymech:consumes	RHEA:22609	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22609		"[{""reference_id"": ""RHEA:22609"", ""source_assertion"": ""Rhea lists CHEBI:58087 on the substrates side of RHEA:22609 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22609']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22609"", ""source_version"": ""139"", ""title"": ""Rhea L,L-diaminopimelate-forming desuccinylase direction"", ""url"": ""https://www.rhea-db.org/rhea/22609""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-039_43fe0ea2bf9a	RHEA:22609	pathwaymech:produces	CHEBI:30031	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22609		"[{""reference_id"": ""RHEA:22609"", ""source_assertion"": ""Rhea lists CHEBI:30031 on the products side of RHEA:22609 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22609']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22609"", ""source_version"": ""139"", ""title"": ""Rhea L,L-diaminopimelate-forming desuccinylase direction"", ""url"": ""https://www.rhea-db.org/rhea/22609""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-040_2fd839e98ec9	RHEA:22609	pathwaymech:produces	CHEBI:57609	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22609		"[{""reference_id"": ""RHEA:22609"", ""source_assertion"": ""Rhea lists CHEBI:57609 on the products side of RHEA:22609 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22609']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22609"", ""source_version"": ""139"", ""title"": ""Rhea L,L-diaminopimelate-forming desuccinylase direction"", ""url"": ""https://www.rhea-db.org/rhea/22609""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-041_ea4778b4e189	CHEBI:57609	pathwaymech:consumes	RHEA:15394	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15394		"[{""reference_id"": ""RHEA:15394"", ""source_assertion"": ""Rhea lists CHEBI:57609 on the substrates side of RHEA:15394 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15394']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15394"", ""source_version"": ""139"", ""title"": ""Rhea meso-diaminopimelate-forming epimerase direction"", ""url"": ""https://www.rhea-db.org/rhea/15394""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-042_0e8f9a7cba20	RHEA:15394	pathwaymech:produces	CHEBI:57791	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15394		"[{""reference_id"": ""RHEA:15394"", ""source_assertion"": ""Rhea lists CHEBI:57791 on the products side of RHEA:15394 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15394']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15394"", ""source_version"": ""139"", ""title"": ""Rhea meso-diaminopimelate-forming epimerase direction"", ""url"": ""https://www.rhea-db.org/rhea/15394""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-043_0e3cee1734de	CHEBI:15378	pathwaymech:consumes	RHEA:15102	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15102		"[{""reference_id"": ""RHEA:15102"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:15102 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15102']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15102"", ""source_version"": ""139"", ""title"": ""Rhea L-lysine-forming diaminopimelate decarboxylase direction"", ""url"": ""https://www.rhea-db.org/rhea/15102""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-044_025327ca515d	CHEBI:57791	pathwaymech:consumes	RHEA:15102	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15102		"[{""reference_id"": ""RHEA:15102"", ""source_assertion"": ""Rhea lists CHEBI:57791 on the substrates side of RHEA:15102 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15102']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15102"", ""source_version"": ""139"", ""title"": ""Rhea L-lysine-forming diaminopimelate decarboxylase direction"", ""url"": ""https://www.rhea-db.org/rhea/15102""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-045_f37a3152fd9b	RHEA:15102	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15102		"[{""reference_id"": ""RHEA:15102"", ""source_assertion"": ""Rhea lists CHEBI:16526 on the products side of RHEA:15102 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15102']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15102"", ""source_version"": ""139"", ""title"": ""Rhea L-lysine-forming diaminopimelate decarboxylase direction"", ""url"": ""https://www.rhea-db.org/rhea/15102""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-046_917161f34ea8	RHEA:15102	pathwaymech:produces	CHEBI:32551	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15102		"[{""reference_id"": ""RHEA:15102"", ""source_assertion"": ""Rhea lists CHEBI:32551 on the products side of RHEA:15102 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15102']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15102"", ""source_version"": ""139"", ""title"": ""Rhea L-lysine-forming diaminopimelate decarboxylase direction"", ""url"": ""https://www.rhea-db.org/rhea/15102""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-047_5592a0021c59	EC:2.7.2.4	pathwaymech:catalyzes	RHEA:23777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23776		"[{""reference_id"": ""RHEA:23776"", ""source_assertion"": ""Rhea associates EC:2.7.2.4 with the reaction family containing RHEA:23777."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:23776"", ""source_version"": ""139"", ""title"": ""Rhea aspartate kinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/23776""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-048_ab5c1f80b114	EC:1.2.1.11	pathwaymech:catalyzes	RHEA:24286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24284		"[{""reference_id"": ""RHEA:24284"", ""source_assertion"": ""Rhea associates EC:1.2.1.11 with the reaction family containing RHEA:24286."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:24284"", ""source_version"": ""139"", ""title"": ""Rhea aspartate-semialdehyde dehydrogenase reaction"", ""url"": ""https://www.rhea-db.org/rhea/24284""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-049_a36e3d568e3c	EC:4.3.3.7	pathwaymech:catalyzes	RHEA:34172	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34171		"[{""reference_id"": ""RHEA:34171"", ""source_assertion"": ""Rhea associates EC:4.3.3.7 with the reaction family containing RHEA:34172."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:34171"", ""source_version"": ""139"", ""title"": ""Rhea 4-hydroxy-tetrahydrodipicolinate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/34171""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-050_21dccc370ec1	EC:1.17.1.8	pathwaymech:catalyzes	RHEA:35325	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35323		"[{""reference_id"": ""RHEA:35323"", ""source_assertion"": ""Rhea associates EC:1.17.1.8 with the reaction family containing RHEA:35325."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:35323"", ""source_version"": ""139"", ""title"": ""Rhea NADH-dependent dihydrodipicolinate reductase reaction"", ""url"": ""https://www.rhea-db.org/rhea/35323""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-051_b060b6b3775d	EC:1.17.1.8	pathwaymech:catalyzes	RHEA:35333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35331		"[{""reference_id"": ""RHEA:35331"", ""source_assertion"": ""Rhea associates EC:1.17.1.8 with the reaction family containing RHEA:35333."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:35331"", ""source_version"": ""139"", ""title"": ""Rhea NADPH-dependent dihydrodipicolinate reductase reaction"", ""url"": ""https://www.rhea-db.org/rhea/35331""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-052_4ed1af2cd308	EC:2.3.1.117	pathwaymech:catalyzes	RHEA:17326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17325		"[{""reference_id"": ""RHEA:17325"", ""source_assertion"": ""Rhea associates EC:2.3.1.117 with the reaction family containing RHEA:17326."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:17325"", ""source_version"": ""139"", ""title"": ""Rhea tetrahydrodipicolinate N-succinyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/17325""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-053_9c8c606a1044	EC:2.6.1.17	pathwaymech:catalyzes	RHEA:11962	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11960		"[{""reference_id"": ""RHEA:11960"", ""source_assertion"": ""Rhea associates EC:2.6.1.17 with the reaction family containing RHEA:11962."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:11960"", ""source_version"": ""139"", ""title"": ""Rhea succinyldiaminopimelate transaminase reaction"", ""url"": ""https://www.rhea-db.org/rhea/11960""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-054_1891991d1bcd	EC:3.5.1.18	pathwaymech:catalyzes	RHEA:22609	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22608		"[{""reference_id"": ""RHEA:22608"", ""source_assertion"": ""Rhea associates EC:3.5.1.18 with the reaction family containing RHEA:22609."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:22608"", ""source_version"": ""139"", ""title"": ""Rhea succinyl-diaminopimelate desuccinylase reaction"", ""url"": ""https://www.rhea-db.org/rhea/22608""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-055_4924e983a1c5	EC:5.1.1.7	pathwaymech:catalyzes	RHEA:15394	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15393		"[{""reference_id"": ""RHEA:15393"", ""source_assertion"": ""Rhea associates EC:5.1.1.7 with the reaction family containing RHEA:15394."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:15393"", ""source_version"": ""139"", ""title"": ""Rhea diaminopimelate epimerase reaction"", ""url"": ""https://www.rhea-db.org/rhea/15393""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-056_8e50145bcfcd	EC:4.1.1.20	pathwaymech:catalyzes	RHEA:15102	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15101		"[{""reference_id"": ""RHEA:15101"", ""source_assertion"": ""Rhea associates EC:4.1.1.20 with the reaction family containing RHEA:15102."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:15101"", ""source_version"": ""139"", ""title"": ""Rhea diaminopimelate decarboxylase reaction"", ""url"": ""https://www.rhea-db.org/rhea/15101""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-057_7f014739b679	RHEA:11962	pathwaymech:precedes	RHEA:22609	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DAPLYSINESYN-PWY		"[{""reference_id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:11962 before RHEA:22609 in this pathway. Shared intermediate: CHEBI:58087."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_sha256"": ""5ef055a95df3fb050f163fca8a8a1f179d436a4221b12f94f6eaecec8765380f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-lysine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:DAPLYSINESYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-058_832e9cab6eaf	RHEA:15394	pathwaymech:precedes	RHEA:15102	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DAPLYSINESYN-PWY		"[{""reference_id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:15394 before RHEA:15102 in this pathway. Shared intermediate: CHEBI:57791."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_sha256"": ""5ef055a95df3fb050f163fca8a8a1f179d436a4221b12f94f6eaecec8765380f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-lysine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:DAPLYSINESYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-059_ba7f287e65c4	RHEA:17326	pathwaymech:precedes	RHEA:11962	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DAPLYSINESYN-PWY		"[{""reference_id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:17326 before RHEA:11962 in this pathway. Shared intermediate: CHEBI:15685."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_sha256"": ""5ef055a95df3fb050f163fca8a8a1f179d436a4221b12f94f6eaecec8765380f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-lysine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:DAPLYSINESYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-060_d3fd82d8d2ac	RHEA:22609	pathwaymech:precedes	RHEA:15394	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DAPLYSINESYN-PWY		"[{""reference_id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:22609 before RHEA:15394 in this pathway. Shared intermediate: CHEBI:57609."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_sha256"": ""5ef055a95df3fb050f163fca8a8a1f179d436a4221b12f94f6eaecec8765380f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-lysine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:DAPLYSINESYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-061_2a67b20909d9	RHEA:23777	pathwaymech:precedes	RHEA:24286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DAPLYSINESYN-PWY		"[{""reference_id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:23777 before RHEA:24286 in this pathway. Shared intermediate: CHEBI:57535."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_sha256"": ""5ef055a95df3fb050f163fca8a8a1f179d436a4221b12f94f6eaecec8765380f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-lysine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:DAPLYSINESYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-062_03b3fae011c3	RHEA:24286	pathwaymech:precedes	RHEA:34172	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DAPLYSINESYN-PWY		"[{""reference_id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:24286 before RHEA:34172 in this pathway. Shared intermediate: CHEBI:537519."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_sha256"": ""5ef055a95df3fb050f163fca8a8a1f179d436a4221b12f94f6eaecec8765380f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-lysine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:DAPLYSINESYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-063_1d62970ff863	RHEA:34172	pathwaymech:precedes	RHEA:35325	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DAPLYSINESYN-PWY		"[{""reference_id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:34172 before RHEA:35325 in this pathway. Shared intermediate: CHEBI:67139."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_sha256"": ""5ef055a95df3fb050f163fca8a8a1f179d436a4221b12f94f6eaecec8765380f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-lysine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:DAPLYSINESYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-064_13cd2529bf94	RHEA:34172	pathwaymech:precedes	RHEA:35333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DAPLYSINESYN-PWY		"[{""reference_id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:34172 before RHEA:35333 in this pathway. Shared intermediate: CHEBI:67139."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_sha256"": ""5ef055a95df3fb050f163fca8a8a1f179d436a4221b12f94f6eaecec8765380f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-lysine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:DAPLYSINESYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-065_96b471cc5e52	RHEA:35325	pathwaymech:precedes	RHEA:17326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DAPLYSINESYN-PWY		"[{""reference_id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:35325 before RHEA:17326 in this pathway. Shared intermediate: CHEBI:16845."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_sha256"": ""5ef055a95df3fb050f163fca8a8a1f179d436a4221b12f94f6eaecec8765380f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-lysine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:DAPLYSINESYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-066_a74575148bd5	RHEA:35333	pathwaymech:precedes	RHEA:17326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DAPLYSINESYN-PWY		"[{""reference_id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:35333 before RHEA:17326 in this pathway. Shared intermediate: CHEBI:16845."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:DAPLYSINESYN-PWY"", ""source_sha256"": ""5ef055a95df3fb050f163fca8a8a1f179d436a4221b12f94f6eaecec8765380f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-lysine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:DAPLYSINESYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-067_c29714a62fdd	UniProtKB:P00561	pathwaymech:enables	RHEA:23777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00561		"[{""reference_id"": ""UniProtKB:P00561"", ""source_assertion"": ""UniProt annotates UniProtKB:P00561 with catalytic activity for the reaction family of RHEA:23777. Annotation evidence: ECO:0000250; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00561"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00561 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00561.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-068_b860c778618d	CHEBI:57926	pathwaymech:regulates	UniProtKB:P00561	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00561		"[{""reference_id"": ""UniProtKB:P00561"", ""source_assertion"": ""UniProt activity-regulation annotation: The enzyme activities are regulated allosterically by L-threonine"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P00561"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00561 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00561.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-069_be3170306a13	UniProtKB:P00562	pathwaymech:enables	RHEA:23777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00562		"[{""reference_id"": ""UniProtKB:P00562"", ""source_assertion"": ""UniProt annotates UniProtKB:P00562 with catalytic activity for the reaction family of RHEA:23777. Annotation evidence: ECO:0000250; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00562"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00562 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00562.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-070_30100f045be0	UniProtKB:P00861	pathwaymech:enables	RHEA:15102	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00861		"[{""reference_id"": ""UniProtKB:P00861"", ""source_assertion"": ""UniProt annotates UniProtKB:P00861 with catalytic activity for the reaction family of RHEA:15102. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00861"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00861 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00861.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-071_f1069400ba9e	UniProtKB:P00861	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00861		"[{""reference_id"": ""UniProtKB:P00861"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P00861 (evidence: ECO:0000269). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P00861"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00861 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00861.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-072_f9741de89e23	UniProtKB:P04036	pathwaymech:enables	RHEA:35325	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P04036		"[{""reference_id"": ""UniProtKB:P04036"", ""source_assertion"": ""UniProt annotates UniProtKB:P04036 with catalytic activity for the reaction family of RHEA:35325. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P04036"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P04036 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P04036.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-073_51654598ed7e	UniProtKB:P04036	pathwaymech:enables	RHEA:35333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P04036		"[{""reference_id"": ""UniProtKB:P04036"", ""source_assertion"": ""UniProt annotates UniProtKB:P04036 with catalytic activity for the reaction family of RHEA:35333. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P04036"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P04036 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P04036.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-074_a77b39820a38	UniProtKB:P04036	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P04036		"[{""reference_id"": ""UniProtKB:P04036"", ""source_assertion"": ""UniProt locates UniProtKB:P04036 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P04036"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P04036 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P04036.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-075_2f1e00f58625	UniProtKB:P08660	pathwaymech:enables	RHEA:23777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08660		"[{""reference_id"": ""UniProtKB:P08660"", ""source_assertion"": ""UniProt annotates UniProtKB:P08660 with catalytic activity for the reaction family of RHEA:23777. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P08660"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P08660 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08660.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-076_4616dd919082	CHEBI:32551	pathwaymech:inhibits	UniProtKB:P08660	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08660		"[{""reference_id"": ""UniProtKB:P08660"", ""source_assertion"": ""UniProt activity-regulation annotation: Synthesis and activity are sensitive to the allosteric inhibitor lysine, one of the end metabolites of the aspartic acid family branched pathway"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P08660"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P08660 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08660.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-077_b9188aadbccf	UniProtKB:P0A6K1	pathwaymech:enables	RHEA:15394	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6K1		"[{""reference_id"": ""UniProtKB:P0A6K1"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A6K1 with catalytic activity for the reaction family of RHEA:15394. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A6K1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6K1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6K1.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-078_01506b7514a5	UniProtKB:P0A6K1	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6K1		"[{""reference_id"": ""UniProtKB:P0A6K1"", ""source_assertion"": ""UniProt locates UniProtKB:P0A6K1 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A6K1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6K1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6K1.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-079_a8e01beffb6f	UniProtKB:P0A6L2	pathwaymech:enables	RHEA:34172	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6L2		"[{""reference_id"": ""UniProtKB:P0A6L2"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A6L2 with catalytic activity for the reaction family of RHEA:34172. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A6L2"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6L2 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6L2.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-080_907fca57f663	CHEBI:32551	pathwaymech:inhibits	UniProtKB:P0A6L2	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6L2		"[{""reference_id"": ""UniProtKB:P0A6L2"", ""source_assertion"": ""UniProt activity-regulation annotation: Is allosterically regulated by the feedback inhibitor (S)-lysine. Is inhibited by pyruvate analogs such as 3-fluoropyruvate, 2-ketobutyrate, glyoxylate, and beta-hydroxypyruvate. Is not inhibited by its substrate, (S)-ASA"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P0A6L2"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6L2 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6L2.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-081_c0187100b0cd	UniProtKB:P0A6L2	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6L2		"[{""reference_id"": ""UniProtKB:P0A6L2"", ""source_assertion"": ""UniProt locates UniProtKB:P0A6L2 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A6L2"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6L2 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6L2.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-082_01b5d5c1427a	UniProtKB:P0A9D8	pathwaymech:enables	RHEA:17326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9D8		"[{""reference_id"": ""UniProtKB:P0A9D8"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A9D8 with catalytic activity for the reaction family of RHEA:17326. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A9D8"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9D8 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9D8.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-083_5ce9b4fb365e	UniProtKB:P0A9D8	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9D8		"[{""reference_id"": ""UniProtKB:P0A9D8"", ""source_assertion"": ""UniProt locates UniProtKB:P0A9D8 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A9D8"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9D8 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9D8.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-084_27990b17f47d	UniProtKB:P0A9Q9	pathwaymech:enables	RHEA:24286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9Q9		"[{""reference_id"": ""UniProtKB:P0A9Q9"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A9Q9 with catalytic activity for the reaction family of RHEA:24286. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A9Q9"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9Q9 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9Q9.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-085_059c246d6fdb	UniProtKB:P0AED7	pathwaymech:enables	RHEA:22609	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AED7		"[{""reference_id"": ""UniProtKB:P0AED7"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AED7 with catalytic activity for the reaction family of RHEA:22609. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AED7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AED7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AED7.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-086_462f1fd94dfb	UniProtKB:P0AED7	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AED7		"[{""reference_id"": ""UniProtKB:P0AED7"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P0AED7 (evidence: ECO:0000269). Binds 2 Zn(2+) or Co(2+) ions per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AED7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AED7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AED7.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-087_57fe6a993e18	UniProtKB:P0AED7	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AED7		"[{""reference_id"": ""UniProtKB:P0AED7"", ""source_assertion"": ""UniProt lists CHEBI:48828 as a cofactor of UniProtKB:P0AED7 (evidence: ECO:0000269). Binds 2 Zn(2+) or Co(2+) ions per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AED7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AED7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AED7.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-088_387787db36d4	UniProtKB:P18335	pathwaymech:enables	RHEA:11962	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P18335		"[{""reference_id"": ""UniProtKB:P18335"", ""source_assertion"": ""UniProt annotates UniProtKB:P18335 with catalytic activity for the reaction family of RHEA:11962. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P18335"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P18335 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P18335.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-089_af68319c848d	UniProtKB:P18335	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P18335		"[{""reference_id"": ""UniProtKB:P18335"", ""source_assertion"": ""UniProt locates UniProtKB:P18335 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255, ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P18335"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P18335 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P18335.json""}]"	""
pathwaymech:MetaCyc_DAPLYSINESYN-PWY_edge-090_d4496ca060a9	UniProtKB:P18335	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P18335		"[{""reference_id"": ""UniProtKB:P18335"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P18335 (evidence: ECO:0000255, ECO:0000305). Binds 1 pyridoxal phosphate per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P18335"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P18335 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P18335.json""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-001_35eb3a85d8bf	gomodel:HOMOCITRATE-SYNTHASE-RXN	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:HOMOCITRATE-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_57287_HOMOCITRATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/0; endpoint types: /individuals/35/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-002_a5379f0fd2f2	gomodel:2-AMINOADIPATE-AMINOTRANSFERASE-RXN	RO:0002233	CHEBI:57499	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:2-AMINOADIPATE-AMINOTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_57499_RXN-7970."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/1; endpoint types: /individuals/112/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-003_bac3334f7981	gomodel:HOMOACONITATE-HYDRATASE-RXN	RO:0002234	CHEBI:15404	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:HOMOACONITATE-HYDRATASE-RXN RO:0002234 gomodel:CHEBI_15404_HOMOACONITATE-HYDRATASE-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/2; endpoint types: /individuals/34/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-004_abfa72b0c438	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001076	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001076 RO:0002234 gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001080."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/3; endpoint types: /individuals/114/type; /individuals/118/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-005_9c2b6e87dca0	gomodel:RXN3O-1983	RO:0002234	CHEBI:58174	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-1983 RO:0002234 gomodel:CHEBI_58174_RXN3O-1983."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/4; endpoint types: /individuals/39/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-006_9c9c8dc3e67f	gomodel:2-AMINOADIPATE-AMINOTRANSFERASE-RXN	RO:0002234	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:2-AMINOADIPATE-AMINOTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_16810_2-AMINOADIPATE-AMINOTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/5; endpoint types: /individuals/112/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-007_1433bd045b01	gomodel:RXN3O-9808	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9808 RO:0002234 gomodel:CHEBI_15377_RXN3O-9808."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/6; endpoint types: /individuals/40/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-008_7ce11310a182	gomodel:HOMOCITRATE-SYNTHASE-RXN	RO:0002233	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:HOMOCITRATE-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_16810_HOMOCITRATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/7; endpoint types: /individuals/35/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-010_1ab5ade545bd	gomodel:HOMOCITRATE-SYNTHASE-RXN	RO:0002233	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:HOMOCITRATE-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_57288_HOMOCITRATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/9; endpoint types: /individuals/35/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-011_b18fb4feaad5	gomodel:HOMOCITRATE-SYNTHASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:HOMOCITRATE-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_15377_HOMOCITRATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/10; endpoint types: /individuals/35/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-012_451cbc7666ce	gomodel:RXN3O-9808	RO:0002233	CHEBI:58672	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9808 RO:0002233 gomodel:CHEBI_58672_2-AMINOADIPATE-AMINOTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/11; endpoint types: /individuals/40/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-013_b608eb3e56e5	gomodel:RXN3O-127	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-127 RO:0002234 gomodel:CHEBI_15377_RXN3O-127."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/12; endpoint types: /individuals/38/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-014_0cb500a6d5aa	gomodel:1.5.1.7-RXN	RO:0002233	CHEBI:57951	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:1.5.1.7-RXN RO:0002233 gomodel:CHEBI_57951_RXN3O-127."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/13; endpoint types: /individuals/111/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-016_bc794fbe6ac3	gomodel:RXN3O-127	RO:0002234	CHEBI:57951	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-127 RO:0002234 gomodel:CHEBI_57951_RXN3O-127."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/15; endpoint types: /individuals/38/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-018_90b8b95af5f9	gomodel:HOMOCITRATE-SYNTHASE-RXN	BFO:0000050	GO:0009085	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:HOMOCITRATE-SYNTHASE-RXN BFO:0000050 gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/YeastPathways_LYSINE-AMINOAD-PWY-2."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/17; endpoint types: /individuals/35/type; /individuals/113/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-019_b478cdeea3fc	gomodel:RXN3O-127	RO:0002233	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-127 RO:0002233 gomodel:CHEBI_29985_RXN3O-127."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/18; endpoint types: /individuals/38/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-020_bce40c316869	gomodel:RXN-7970	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN-7970 RO:0002234 gomodel:CHEBI_16526_RXN-7970."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/19; endpoint types: /individuals/37/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-021_80ca87aafa55	gomodel:HOMOCITRATE-SYNTHASE-RXN	RO:0002234	CHEBI:58884	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:HOMOCITRATE-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_58884_HOMOCITRATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/20; endpoint types: /individuals/35/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-022_47a56e1445b2	gomodel:RXN3O-9808	RO:0002234	CHEBI:58321	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9808 RO:0002234 gomodel:CHEBI_58321_RXN3O-9808."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/21; endpoint types: /individuals/40/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-024_6d7e3e399ab4	gomodel:1.5.1.7-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:1.5.1.7-RXN RO:0002234 gomodel:CHEBI_15378_1.5.1.7-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/23; endpoint types: /individuals/111/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-025_9f105f43039c	gomodel:RXN-7970	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN-7970 RO:0002234 gomodel:CHEBI_57945_RXN-7970."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/24; endpoint types: /individuals/37/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-026_d9651f5018c5	gomodel:2-AMINOADIPATE-AMINOTRANSFERASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:2-AMINOADIPATE-AMINOTRANSFERASE-RXN BFO:0000066 gomodel:reaction_2-AMINOADIPATE-AMINOTRANSFERASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/25; endpoint types: /individuals/112/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-027_ae5147582037	SGD:S000002642	pathwaymech:enables	gomodel:HOMOACONITATE-HYDRATASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:HOMOACONITATE-HYDRATASE-RXN RO:0002333 gomodel:YDR234W-MONOMER_HOMOACONITATE-HYDRATASE-RXN_controller."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/26; endpoint types: /individuals/34/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-028_678129ed3a5d	gomodel:RXN-7970	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN-7970 RO:0002233 gomodel:CHEBI_57540_RXN-7970."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/27; endpoint types: /individuals/37/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-029_5a63bbc9ad91	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001076	RO:0002233	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001076 RO:0002233 gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001077."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/28; endpoint types: /individuals/114/type; /individuals/115/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-030_f766ec908138	SGD:S000001356	pathwaymech:enables	gomodel:RXN-7970	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN-7970 RO:0002333 gomodel:YIL094C-MONOMER_RXN-7970_controller."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/29; endpoint types: /individuals/37/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-031_842c10b051e0	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001076	RO:0002234	CHEBI:58884	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001076 RO:0002234 gomodel:CHEBI_58884_HOMOCITRATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/30; endpoint types: /individuals/114/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-032_82c4a3c61089	gomodel:RXN3O-1983	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-1983 RO:0002234 gomodel:CHEBI_15377_RXN3O-1983."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/31; endpoint types: /individuals/39/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-033_61cb934448c0	gomodel:RXN3O-9808	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9808 RO:0002233 gomodel:CHEBI_57783_RXN3O-9808."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/32; endpoint types: /individuals/40/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-034_d4390f473de4	gomodel:RXN3O-9808	BFO:0000050	GO:0009085	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9808 BFO:0000050 gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/YeastPathways_LYSINE-AMINOAD-PWY-2."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/33; endpoint types: /individuals/40/type; /individuals/113/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-035_588176170808	gomodel:RXN-7970	BFO:0000050	GO:0009085	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN-7970 BFO:0000050 gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/YeastPathways_LYSINE-AMINOAD-PWY-2."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/34; endpoint types: /individuals/37/type; /individuals/113/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-036_0911bdfd59ce	gomodel:1.5.1.7-RXN	BFO:0000050	GO:0009085	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:1.5.1.7-RXN BFO:0000050 gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/YeastPathways_LYSINE-AMINOAD-PWY-2."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/35; endpoint types: /individuals/111/type; /individuals/113/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-037_c3c197dbd25e	gomodel:2-AMINOADIPATE-AMINOTRANSFERASE-RXN	RO:0002234	CHEBI:58672	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:2-AMINOADIPATE-AMINOTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_58672_2-AMINOADIPATE-AMINOTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/36; endpoint types: /individuals/112/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-038_dff4aae5237f	gomodel:RXN3O-127	BFO:0000050	GO:0009085	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-127 BFO:0000050 gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/YeastPathways_LYSINE-AMINOAD-PWY-2."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/37; endpoint types: /individuals/38/type; /individuals/113/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-039_e052cb21cd38	gomodel:RXN3O-9808	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9808 RO:0002234 gomodel:CHEBI_58349_RXN3O-9808."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/38; endpoint types: /individuals/40/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-040_5fdf5a2fac8b	gomodel:HOMOCITRATE-SYNTHASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:HOMOCITRATE-SYNTHASE-RXN BFO:0000066 gomodel:reaction_HOMOCITRATE-SYNTHASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/39; endpoint types: /individuals/35/type; /individuals/106/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-041_b2a8cf0ff8b0	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001076	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001076 RO:0002233 gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001079."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/40; endpoint types: /individuals/114/type; /individuals/117/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-042_806e11f8257d	gomodel:RXN3O-127	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-127 RO:0002233 gomodel:CHEBI_15378_RXN3O-127."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/41; endpoint types: /individuals/38/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-043_e0c7ff33b1f8	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001076	BFO:0000050	GO:0009085	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001076 BFO:0000050 gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/YeastPathways_LYSINE-AMINOAD-PWY-2."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/42; endpoint types: /individuals/114/type; /individuals/113/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-044_86bbf91ea6ee	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001076	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001076 RO:0002234 gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001081."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/43; endpoint types: /individuals/114/type; /individuals/119/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-045_db5e74dc8de4	SGD:S000001473	pathwaymech:enables	gomodel:1.5.1.7-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:1.5.1.7-RXN RO:0002333 gomodel:YIR034C-MONOMER_1.5.1.7-RXN_controller."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/44; endpoint types: /individuals/111/type; /individuals/46/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-046_b09bbf486ab4	gomodel:HOMOACONITATE-HYDRATASE-RXN	BFO:0000050	GO:0009085	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:HOMOACONITATE-HYDRATASE-RXN BFO:0000050 gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/YeastPathways_LYSINE-AMINOAD-PWY-2."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/45; endpoint types: /individuals/34/type; /individuals/113/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-047_96fb1de7e9ab	gomodel:RXN3O-127	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-127 BFO:0000066 gomodel:reaction_RXN3O-127_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/46; endpoint types: /individuals/38/type; /individuals/108/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-049_b0c2ad5271e8	gomodel:2-AMINOADIPATE-AMINOTRANSFERASE-RXN	RO:0002233	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:2-AMINOADIPATE-AMINOTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_29985_2-AMINOADIPATE-AMINOTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/48; endpoint types: /individuals/112/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-050_82437cf6ec70	gomodel:RXN3O-127	RO:0002233	CHEBI:58321	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-127 RO:0002233 gomodel:CHEBI_58321_RXN3O-9808."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/49; endpoint types: /individuals/38/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-051_3b96482e2527	gomodel:RXN-7970	RO:0002234	CHEBI:57499	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN-7970 RO:0002234 gomodel:CHEBI_57499_RXN-7970."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/50; endpoint types: /individuals/37/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-052_cda9aae5869b	SGD:S000002289	pathwaymech:enables	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001076	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001076 RO:0002333 gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001082."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/51; endpoint types: /individuals/114/type; /individuals/120/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-053_2247f3037b35	gomodel:RXN-7970	RO:0002233	CHEBI:15404	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN-7970 RO:0002233 gomodel:CHEBI_15404_HOMOACONITATE-HYDRATASE-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/52; endpoint types: /individuals/37/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-054_ac17d434f617	gomodel:1.5.1.7-RXN	RO:0002234	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:1.5.1.7-RXN RO:0002234 gomodel:CHEBI_16810_1.5.1.7-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/53; endpoint types: /individuals/111/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-055_0cc99a2fd398	gomodel:2-AMINOADIPATE-AMINOTRANSFERASE-RXN	BFO:0000050	GO:0009085	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:2-AMINOADIPATE-AMINOTRANSFERASE-RXN BFO:0000050 gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/YeastPathways_LYSINE-AMINOAD-PWY-2."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/54; endpoint types: /individuals/112/type; /individuals/113/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-056_b72baae1e602	gomodel:RXN3O-9808	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9808 RO:0002233 gomodel:CHEBI_15378_RXN3O-9808."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/55; endpoint types: /individuals/40/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-057_23f94541386e	gomodel:RXN3O-127	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-127 RO:0002234 gomodel:CHEBI_58349_RXN3O-127."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/56; endpoint types: /individuals/38/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-059_68d1506fe382	SGD:S000005333	pathwaymech:enables	gomodel:RXN3O-127	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-127 RO:0002333 gomodel:MONOMER3O-363_RXN3O-127_controller."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/58; endpoint types: /individuals/38/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-060_6bddc6d659c4	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001076	RO:0002233	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001076 RO:0002233 gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/6a4c244800001078."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/59; endpoint types: /individuals/114/type; /individuals/116/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-061_06d1d0d12a23	SGD:S000000319	pathwaymech:enables	gomodel:RXN3O-9808	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9808 RO:0002333 gomodel:YBR115C-MONOMER_RXN3O-9808_controller."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/60; endpoint types: /individuals/40/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-062_cec6df102332	SGD:S000002341	pathwaymech:enables	gomodel:HOMOCITRATE-SYNTHASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:HOMOCITRATE-SYNTHASE-RXN RO:0002333 gomodel:YDL182W-MONOMER_HOMOCITRATE-SYNTHASE-RXN_controller."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/61; endpoint types: /individuals/35/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-063_b96cbcdd8d35	gomodel:1.5.1.7-RXN	RO:0002234	CHEBI:32551	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:1.5.1.7-RXN RO:0002234 gomodel:CHEBI_32551_1.5.1.7-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/62; endpoint types: /individuals/111/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-064_444bf741788e	gomodel:RXN3O-127	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-127 RO:0002233 gomodel:CHEBI_57783_RXN3O-127."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/63; endpoint types: /individuals/38/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-065_cadfdeb7c4a6	gomodel:HOMOCITRATE-SYNTHASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:HOMOCITRATE-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_15378_HOMOCITRATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/64; endpoint types: /individuals/35/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-066_1abd5c021f0f	gomodel:HOMOACONITATE-HYDRATASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:HOMOACONITATE-HYDRATASE-RXN RO:0002233 gomodel:CHEBI_15377_HOMOACONITATE-HYDRATASE-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/65; endpoint types: /individuals/34/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-067_0fdf646ced7b	SGD:S000003170	pathwaymech:enables	gomodel:2-AMINOADIPATE-AMINOTRANSFERASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:2-AMINOADIPATE-AMINOTRANSFERASE-RXN RO:0002333 gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/67c10cc400000549."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/66; endpoint types: /individuals/112/type; /individuals/131/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-068_dc4d8fdccc8c	gomodel:RXN3O-1983	BFO:0000050	GO:0009085	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-1983 BFO:0000050 gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2/YeastPathways_LYSINE-AMINOAD-PWY-2."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/67; endpoint types: /individuals/39/type; /individuals/113/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-069_c507dfc7d9da	gomodel:RXN3O-9808	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9808 BFO:0000066 gomodel:reaction_RXN3O-9808_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/68; endpoint types: /individuals/40/type; /individuals/110/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-070_b7f9363346ae	gomodel:RXN3O-1983	RO:0002233	CHEBI:58884	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:RXN3O-1983 RO:0002233 gomodel:CHEBI_58884_HOMOCITRATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/69; endpoint types: /individuals/39/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-071_1783f84763af	gomodel:1.5.1.7-RXN	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:1.5.1.7-RXN RO:0002234 gomodel:CHEBI_57945_1.5.1.7-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/70; endpoint types: /individuals/111/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-072_bd5a0c2d6ea9	gomodel:1.5.1.7-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:1.5.1.7-RXN RO:0002233 gomodel:CHEBI_15377_1.5.1.7-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/71; endpoint types: /individuals/111/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-073_415917eee18d	gomodel:HOMOACONITATE-HYDRATASE-RXN	RO:0002233	CHEBI:58174	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:HOMOACONITATE-HYDRATASE-RXN RO:0002233 gomodel:CHEBI_58174_RXN3O-1983."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/72; endpoint types: /individuals/34/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_edge-074_26d67502950e	gomodel:1.5.1.7-RXN	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2		"[{""reference_id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_assertion"": ""The model asserts gomodel:1.5.1.7-RXN RO:0002233 gomodel:CHEBI_57540_1.5.1.7-RXN."", ""source_locator"": ""./YeastPathways_LYSINE-AMINOAD-PWY-2.json#/facts/73; endpoint types: /individuals/111/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_LYSINE-AMINOAD-PWY-2"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_LYSINE-AMINOAD-PWY-2.json"", ""title"": ""SGD GO-CAM L-lysine biosynthesis IV model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_location-3351dd7b0aa1_94d51c0ccfc4	SGD:S000002642	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P49367	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P49367"", ""source_assertion"": ""UniProtKB:P49367 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3908/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P49367"", ""source_assertion"": ""UniProtKB:P49367 has the exact SGD cross-reference SGD:S000002642."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3908/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P49367"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P49367 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_location-6976462df38b_abeeeb1c1c97	SGD:S000001356	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40495	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:14576278)	"[{""reference_id"": ""UniProtKB:P40495"", ""source_assertion"": ""UniProtKB:P40495 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1737/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P40495"", ""source_assertion"": ""UniProtKB:P40495 has the exact SGD cross-reference SGD:S000001356."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1737/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40495"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40495 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_location-acaa91a5e755_eed8ae61718a	SGD:S000001473	RO:0001025	GO:0005777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38998	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:26928762); ECO:0000269 (PubMed:28928432)	"[{""reference_id"": ""UniProtKB:P38998"", ""source_assertion"": ""UniProtKB:P38998 annotates location Peroxisome (SL-0204)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1534/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38998"", ""source_assertion"": ""UniProtKB:P38998 has the exact SGD cross-reference SGD:S000001473."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1534/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38998"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38998 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_location-341ce2704a36_b27752f9af41	SGD:S000002289	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12122	Physical protein location from reviewed UniProt. ECO:0000305	"[{""reference_id"": ""UniProtKB:Q12122"", ""source_assertion"": ""UniProtKB:Q12122 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4309/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q12122"", ""source_assertion"": ""UniProtKB:Q12122 has the exact SGD cross-reference SGD:S000002289."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4309/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q12122"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12122 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_location-351d7577066c_e01b2e2ba22e	SGD:S000002341	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P48570	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P48570"", ""source_assertion"": ""UniProtKB:P48570 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3903/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P48570"", ""source_assertion"": ""UniProtKB:P48570 has the exact SGD cross-reference SGD:S000002341."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3903/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P48570"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P48570 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_location-ad4354e8d3df_2aa81eca1d38	SGD:S000003170	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53090	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2112/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 has the exact SGD cross-reference SGD:S000003170."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2112/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53090"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53090 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_assignment-P39533-homocitrate_b2367e2f7d3c	SGD:S000003736	pathwaymech:enables	gomodel:RXN3O-1983	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39533	PMID:23106124 separates homocitrate dehydration (ACO2, with minor ACO1 contribution) from homoaconitate hydration (LYS4).	"[{""reference_id"": ""UniProtKB:P39533"", ""source_assertion"": ""UniProt P39533 assigns reversible (R)-homocitrate dehydration to cis-homoaconitate to ACO2, supported by PMID:23106124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/1568/comments/0""}, {""reference_id"": ""UniProtKB:P39533"", ""source_assertion"": ""UniProt P39533 has the exact SGD cross-reference SGD:S000003736."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/1568/uniProtKBCrossReferences""}]"	"[{""id"": ""UniProtKB:P39533"", ""source_sha256"": ""9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c"", ""source_version"": ""2026_03"", ""title"": ""Reviewed UniProt P39533: catalytic-function assertions"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_assignment-location-P39533-SL-0173_7ff24134fbd2	SGD:S000003736	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39533	Physical protein location; does not place every activity of this enzyme in this compartment. ACO1 is mainly mitochondrial.	"[{""reference_id"": ""UniProtKB:P39533"", ""source_assertion"": ""UniProt P39533 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d] #/results/1568/comments/1/subcellularLocations/0""}]"	"[{""id"": ""UniProtKB:P39533"", ""source_sha256"": ""9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c"", ""source_version"": ""2026_03"", ""title"": ""Reviewed UniProt P39533: catalytic-function assertions"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_assignment-P19414-homocitrate_d328c70ecd18	SGD:S000004295	pathwaymech:enables	gomodel:RXN3O-1983	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P19414	PMID:23106124 separates homocitrate dehydration (ACO2, with minor ACO1 contribution) from homoaconitate hydration (LYS4).	"[{""reference_id"": ""UniProtKB:P19414"", ""source_assertion"": ""UniProt P19414 assigns a minor contribution to reversible (R)-homocitrate dehydration to ACO1, supported by PMID:23106124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/497/comments/0""}, {""reference_id"": ""UniProtKB:P19414"", ""source_assertion"": ""UniProt P19414 has the exact SGD cross-reference SGD:S000004295."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/497/uniProtKBCrossReferences""}]"	"[{""id"": ""UniProtKB:P19414"", ""source_sha256"": ""9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c"", ""source_version"": ""2026_03"", ""title"": ""Reviewed UniProt P19414: catalytic-function assertions"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_assignment-location-P19414-SL-0173_ce38c10a6964	SGD:S000004295	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P19414	Physical protein location; does not place every activity of this enzyme in this compartment. ACO1 is mainly mitochondrial.	"[{""reference_id"": ""UniProtKB:P19414"", ""source_assertion"": ""UniProt P19414 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d] #/results/497/comments/1/subcellularLocations/0""}]"	"[{""id"": ""UniProtKB:P19414"", ""source_sha256"": ""9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c"", ""source_version"": ""2026_03"", ""title"": ""Reviewed UniProt P19414: catalytic-function assertions"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_assignment-location-P19414-SL-0086_c27cb4535939	SGD:S000004295	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P19414	Physical protein location; does not place every activity of this enzyme in this compartment. ACO1 is mainly mitochondrial.	"[{""reference_id"": ""UniProtKB:P19414"", ""source_assertion"": ""UniProt P19414 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d] #/results/497/comments/1/subcellularLocations/1""}]"	"[{""id"": ""UniProtKB:P19414"", ""source_sha256"": ""9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c"", ""source_version"": ""2026_03"", ""title"": ""Reviewed UniProt P19414: catalytic-function assertions"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_cofactor-1c1ee0a98ecb_6524277b85cb	SGD:S000002642	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P49367	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 [4Fe-4S] cluster per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P49367"", ""source_assertion"": ""UniProtKB:P49367 annotates CHEBI:49883 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3908/comments/0/cofactors/0; /results/3908/comments/0/note""}, {""reference_id"": ""UniProtKB:P49367"", ""source_assertion"": ""UniProtKB:P49367 has the exact SGD cross-reference SGD:S000002642."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3908/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P49367"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P49367 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_cofactor-44c68a2de3f2_ab4680605974	SGD:S000001356	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40495	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:17223711); ECO:0000269 (PubMed:19530703) Binds 1 Mg(2+) ion per subunit. UniProt note evidence: ECO:0000269 (PubMed:17223711); ECO:0000269 (PubMed:19530703)	"[{""reference_id"": ""UniProtKB:P40495"", ""source_assertion"": ""UniProtKB:P40495 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1737/comments/0/cofactors/0; /results/1737/comments/0/note""}, {""reference_id"": ""UniProtKB:P40495"", ""source_assertion"": ""UniProtKB:P40495 has the exact SGD cross-reference SGD:S000001356."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1737/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P40495"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40495 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_cofactor-f341161c325f_9869387e0262	SGD:S000002289	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12122	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:O87198)	"[{""reference_id"": ""UniProtKB:Q12122"", ""source_assertion"": ""UniProtKB:Q12122 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4309/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:Q12122"", ""source_assertion"": ""UniProtKB:Q12122 has the exact SGD cross-reference SGD:S000002289."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4309/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q12122"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12122 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_cofactor-223c96521f5d_b8c9a8e1ade2	SGD:S000002289	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12122	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:O87198)	"[{""reference_id"": ""UniProtKB:Q12122"", ""source_assertion"": ""UniProtKB:Q12122 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4309/comments/0/cofactors/1""}, {""reference_id"": ""UniProtKB:Q12122"", ""source_assertion"": ""UniProtKB:Q12122 has the exact SGD cross-reference SGD:S000002289."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4309/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q12122"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12122 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_cofactor-3095c3302987_b4569d10be1a	SGD:S000000319	pathwaymech:has_cofactor	CHEBI:47942	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07702	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The source describes a covalently attached cofactor moiety. Keep that bound-state qualification; no free cosubstrate consumption is inferred. UniProt evidence: ECO:0000269 (PubMed:10320345) Binds 1 phosphopantetheine covalently. UniProt note evidence: ECO:0000269 (PubMed:10320345)	"[{""reference_id"": ""UniProtKB:P07702"", ""source_assertion"": ""UniProtKB:P07702 annotates CHEBI:47942 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/193/comments/0/cofactors/0; /results/193/comments/0/note""}, {""reference_id"": ""UniProtKB:P07702"", ""source_assertion"": ""UniProtKB:P07702 has the exact SGD cross-reference SGD:S000000319."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/193/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P07702"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P07702 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_cofactor-ec0c79b41c00_f2ebba51940f	SGD:S000002341	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P48570	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:O87198)	"[{""reference_id"": ""UniProtKB:P48570"", ""source_assertion"": ""UniProtKB:P48570 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3903/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P48570"", ""source_assertion"": ""UniProtKB:P48570 has the exact SGD cross-reference SGD:S000002341."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3903/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P48570"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P48570 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_cofactor-f90a9e118814_ec711b023e69	SGD:S000002341	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P48570	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:O87198)	"[{""reference_id"": ""UniProtKB:P48570"", ""source_assertion"": ""UniProtKB:P48570 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3903/comments/0/cofactors/1""}, {""reference_id"": ""UniProtKB:P48570"", ""source_assertion"": ""UniProtKB:P48570 has the exact SGD cross-reference SGD:S000002341."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3903/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P48570"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P48570 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_cofactor-46a0dec0bfb8_fc9a91b056a2	SGD:S000003170	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53090	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:23893908)	"[{""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 has the exact SGD cross-reference SGD:S000003170."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53090"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53090 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_cofactor-481201c433a2_b923001b0598	SGD:S000003736	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39533	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P20004) Binds 1 [4Fe-4S] cluster per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P20004)	"[{""reference_id"": ""UniProtKB:P39533"", ""source_assertion"": ""UniProtKB:P39533 annotates CHEBI:49883 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1568/comments/0/cofactors/0; /results/1568/comments/0/note""}, {""reference_id"": ""UniProtKB:P39533"", ""source_assertion"": ""UniProtKB:P39533 has the exact SGD cross-reference SGD:S000003736."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1568/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P39533"", ""source_sha256"": ""9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c"", ""source_version"": ""2026_03"", ""title"": ""Reviewed UniProt P39533: catalytic-function assertions"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_LYSINE-AMINOAD-PWY-2_cofactor-59597f700ba3_7b3b862f00b9	SGD:S000004295	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P19414	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:27738674) Binds 1 [4Fe-4S] cluster per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P20004)	"[{""reference_id"": ""UniProtKB:P19414"", ""source_assertion"": ""UniProtKB:P19414 annotates CHEBI:49883 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/497/comments/0/cofactors/0; /results/497/comments/0/note""}, {""reference_id"": ""UniProtKB:P19414"", ""source_assertion"": ""UniProtKB:P19414 has the exact SGD cross-reference SGD:S000004295."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/497/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P19414"", ""source_sha256"": ""9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c"", ""source_version"": ""2026_03"", ""title"": ""Reviewed UniProt P19414: catalytic-function assertions"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-001_f4aa3b162b19	CHEBI:57292	pathwaymech:consumes	RHEA:22009	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22009		"[{""reference_id"": ""RHEA:22009"", ""source_assertion"": ""Rhea lists CHEBI:57292 on the substrates side of RHEA:22009 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22009']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22009"", ""source_version"": ""139"", ""title"": ""Rhea O-succinylhomoserine-forming homoserine O-succinyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/22009""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-002_d4bee62c2360	CHEBI:57476	pathwaymech:consumes	RHEA:22009	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22009		"[{""reference_id"": ""RHEA:22009"", ""source_assertion"": ""Rhea lists CHEBI:57476 on the substrates side of RHEA:22009 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22009']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22009"", ""source_version"": ""139"", ""title"": ""Rhea O-succinylhomoserine-forming homoserine O-succinyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/22009""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-003_eb9314329cce	RHEA:22009	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22009		"[{""reference_id"": ""RHEA:22009"", ""source_assertion"": ""Rhea lists CHEBI:57287 on the products side of RHEA:22009 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22009']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22009"", ""source_version"": ""139"", ""title"": ""Rhea O-succinylhomoserine-forming homoserine O-succinyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/22009""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-004_b2409ef652ac	RHEA:22009	pathwaymech:produces	CHEBI:57661	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22009		"[{""reference_id"": ""RHEA:22009"", ""source_assertion"": ""Rhea lists CHEBI:57661 on the products side of RHEA:22009 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22009']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22009"", ""source_version"": ""139"", ""title"": ""Rhea O-succinylhomoserine-forming homoserine O-succinyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/22009""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-005_12bcbdff50c5	CHEBI:35235	pathwaymech:consumes	RHEA:20398	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20398		"[{""reference_id"": ""RHEA:20398"", ""source_assertion"": ""Rhea lists CHEBI:35235 on the substrates side of RHEA:20398 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20398']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20398"", ""source_version"": ""139"", ""title"": ""Rhea L,L-cystathionine-forming cystathionine gamma-synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/20398""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-006_905f85c87b56	CHEBI:57661	pathwaymech:consumes	RHEA:20398	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20398		"[{""reference_id"": ""RHEA:20398"", ""source_assertion"": ""Rhea lists CHEBI:57661 on the substrates side of RHEA:20398 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20398']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20398"", ""source_version"": ""139"", ""title"": ""Rhea L,L-cystathionine-forming cystathionine gamma-synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/20398""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-007_00efbc7f6799	RHEA:20398	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20398		"[{""reference_id"": ""RHEA:20398"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:20398 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20398']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20398"", ""source_version"": ""139"", ""title"": ""Rhea L,L-cystathionine-forming cystathionine gamma-synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/20398""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-008_f9c419b154fd	RHEA:20398	pathwaymech:produces	CHEBI:30031	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20398		"[{""reference_id"": ""RHEA:20398"", ""source_assertion"": ""Rhea lists CHEBI:30031 on the products side of RHEA:20398 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20398']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20398"", ""source_version"": ""139"", ""title"": ""Rhea L,L-cystathionine-forming cystathionine gamma-synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/20398""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-009_d685b4f29934	RHEA:20398	pathwaymech:produces	CHEBI:58161	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20398		"[{""reference_id"": ""RHEA:20398"", ""source_assertion"": ""Rhea lists CHEBI:58161 on the products side of RHEA:20398 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20398']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20398"", ""source_version"": ""139"", ""title"": ""Rhea L,L-cystathionine-forming cystathionine gamma-synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/20398""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-010_a5fa5830d828	CHEBI:18608	pathwaymech:consumes	RHEA:11173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11173		"[{""reference_id"": ""RHEA:11173"", ""source_assertion"": ""Rhea lists CHEBI:18608 on the substrates side of RHEA:11173 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11173']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11173"", ""source_version"": ""139"", ""title"": ""Rhea tetrahydrofolate-dependent L-methionine-forming methionine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/11173""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-011_f4d1bde02c20	CHEBI:58199	pathwaymech:consumes	RHEA:11173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11173		"[{""reference_id"": ""RHEA:11173"", ""source_assertion"": ""Rhea lists CHEBI:58199 on the substrates side of RHEA:11173 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11173']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11173"", ""source_version"": ""139"", ""title"": ""Rhea tetrahydrofolate-dependent L-methionine-forming methionine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/11173""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-012_f212ae3df990	RHEA:11173	pathwaymech:produces	CHEBI:57453	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11173		"[{""reference_id"": ""RHEA:11173"", ""source_assertion"": ""Rhea lists CHEBI:57453 on the products side of RHEA:11173 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11173']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11173"", ""source_version"": ""139"", ""title"": ""Rhea tetrahydrofolate-dependent L-methionine-forming methionine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/11173""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-013_ec1d92e88c0e	RHEA:11173	pathwaymech:produces	CHEBI:57844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11173		"[{""reference_id"": ""RHEA:11173"", ""source_assertion"": ""Rhea lists CHEBI:57844 on the products side of RHEA:11173 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11173']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11173"", ""source_version"": ""139"", ""title"": ""Rhea tetrahydrofolate-dependent L-methionine-forming methionine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/11173""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-014_504acc92183b	CHEBI:58199	pathwaymech:consumes	RHEA:21197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21197		"[{""reference_id"": ""RHEA:21197"", ""source_assertion"": ""Rhea lists CHEBI:58199 on the substrates side of RHEA:21197 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21197']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21197"", ""source_version"": ""139"", ""title"": ""Rhea tetrahydropteroyltriglutamate-dependent L-methionine-forming methionine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/21197""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-015_013162bec6e0	CHEBI:58207	pathwaymech:consumes	RHEA:21197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21197		"[{""reference_id"": ""RHEA:21197"", ""source_assertion"": ""Rhea lists CHEBI:58207 on the substrates side of RHEA:21197 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21197']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21197"", ""source_version"": ""139"", ""title"": ""Rhea tetrahydropteroyltriglutamate-dependent L-methionine-forming methionine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/21197""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-016_2ea796ef5f5b	RHEA:21197	pathwaymech:produces	CHEBI:57844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21197		"[{""reference_id"": ""RHEA:21197"", ""source_assertion"": ""Rhea lists CHEBI:57844 on the products side of RHEA:21197 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21197']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21197"", ""source_version"": ""139"", ""title"": ""Rhea tetrahydropteroyltriglutamate-dependent L-methionine-forming methionine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/21197""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-017_d47bfbbcb297	RHEA:21197	pathwaymech:produces	CHEBI:58140	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21197		"[{""reference_id"": ""RHEA:21197"", ""source_assertion"": ""Rhea lists CHEBI:58140 on the products side of RHEA:21197 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21197']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21197"", ""source_version"": ""139"", ""title"": ""Rhea tetrahydropteroyltriglutamate-dependent L-methionine-forming methionine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/21197""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-018_4d8739cea521	CHEBI:58161	pathwaymech:consumes	RHEA:43021	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43021		"[{""reference_id"": ""RHEA:43021"", ""source_assertion"": ""Rhea lists CHEBI:58161 on the substrates side of RHEA:43021 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/43021']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:43021"", ""source_version"": ""139"", ""title"": ""RHEA:43021 authority record"", ""url"": ""https://www.rhea-db.org/rhea/43021""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-019_6f2966b9b661	RHEA:43021	pathwaymech:produces	CHEBI:58199	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43021		"[{""reference_id"": ""RHEA:43021"", ""source_assertion"": ""Rhea lists CHEBI:58199 on the products side of RHEA:43021 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/43021']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:43021"", ""source_version"": ""139"", ""title"": ""RHEA:43021 authority record"", ""url"": ""https://www.rhea-db.org/rhea/43021""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-020_0adce136e9f2	RHEA:43021	pathwaymech:produces	CHEBI:76565	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43021		"[{""reference_id"": ""RHEA:43021"", ""source_assertion"": ""Rhea lists CHEBI:76565 on the products side of RHEA:43021 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/43021']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:43021"", ""source_version"": ""139"", ""title"": ""RHEA:43021 authority record"", ""url"": ""https://www.rhea-db.org/rhea/43021""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-021_532dba7b1c84	CHEBI:76565	pathwaymech:consumes	RHEA:40668	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40668		"[{""reference_id"": ""RHEA:40668"", ""source_assertion"": ""Rhea lists CHEBI:76565 on the substrates side of RHEA:40668 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40668']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:40668"", ""source_version"": ""139"", ""title"": ""RHEA:40668 authority record"", ""url"": ""https://www.rhea-db.org/rhea/40668""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-022_4ac26626947b	RHEA:40668	pathwaymech:produces	CHEBI:44400	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40668		"[{""reference_id"": ""RHEA:40668"", ""source_assertion"": ""Rhea lists CHEBI:44400 on the products side of RHEA:40668 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40668']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:40668"", ""source_version"": ""139"", ""title"": ""RHEA:40668 authority record"", ""url"": ""https://www.rhea-db.org/rhea/40668""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-023_11cd45db153d	CHEBI:15377	pathwaymech:consumes	RHEA:40672	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40672		"[{""reference_id"": ""RHEA:40672"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:40672 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40672']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:40672"", ""source_version"": ""139"", ""title"": ""RHEA:40672 authority record"", ""url"": ""https://www.rhea-db.org/rhea/40672""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-024_a21c940fce45	CHEBI:44400	pathwaymech:consumes	RHEA:40672	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40672		"[{""reference_id"": ""RHEA:40672"", ""source_assertion"": ""Rhea lists CHEBI:44400 on the substrates side of RHEA:40672 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40672']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:40672"", ""source_version"": ""139"", ""title"": ""RHEA:40672 authority record"", ""url"": ""https://www.rhea-db.org/rhea/40672""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-025_86eb01abc9be	RHEA:40672	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40672		"[{""reference_id"": ""RHEA:40672"", ""source_assertion"": ""Rhea lists CHEBI:15361 on the products side of RHEA:40672 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40672']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:40672"", ""source_version"": ""139"", ""title"": ""RHEA:40672 authority record"", ""url"": ""https://www.rhea-db.org/rhea/40672""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-026_24ae3f53497f	RHEA:40672	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40672		"[{""reference_id"": ""RHEA:40672"", ""source_assertion"": ""Rhea lists CHEBI:28938 on the products side of RHEA:40672 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40672']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:40672"", ""source_version"": ""139"", ""title"": ""RHEA:40672 authority record"", ""url"": ""https://www.rhea-db.org/rhea/40672""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-027_863279caf9eb	EC:2.3.1.46	pathwaymech:catalyzes	RHEA:22009	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:10572016|RHEA:22008		"[{""reference_id"": ""RHEA:22008"", ""source_assertion"": ""Rhea associates EC:2.3.1.46 with the reaction family containing RHEA:22009."", ""source_locator"": ""rh:ec""}, {""quote"": ""Enzyme-catalyzed acylation of homoserine: mechanistic characterization of the Escherichia coli metA-encoded homoserine transsuccinylase."", ""reference_id"": ""PMID:10572016"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Born and Blanchard, Biochemistry, 1999"", ""id"": ""PMID:10572016"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/10572016/""}, {""id"": ""RHEA:22008"", ""source_version"": ""139"", ""title"": ""Rhea homoserine O-succinyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/22008""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-028_3d6d82a45fe8	EC:2.5.1.48	pathwaymech:catalyzes	RHEA:20398	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:2405903|RHEA:20397		"[{""reference_id"": ""RHEA:20397"", ""source_assertion"": ""Rhea associates EC:2.5.1.48 with the reaction family containing RHEA:20398."", ""source_locator"": ""rh:ec""}, {""quote"": ""Purification and properties of cystathionine gamma-synthase from overproducing strains of Escherichia coli."", ""reference_id"": ""PMID:2405903"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Holbrook et al., Biochemistry, 1990"", ""id"": ""PMID:2405903"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/2405903/""}, {""id"": ""RHEA:20397"", ""source_version"": ""139"", ""title"": ""Rhea cystathionine gamma-synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/20397""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-029_4ac2a0c2ccd3	UniProtKB:P06721	pathwaymech:catalyzes	RHEA:43021	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HOMOSER-METSYN-PWY|PMID:7049234		"[{""reference_id"": ""MetaCyc:HOMOSER-METSYN-PWY"", ""source_assertion"": ""The native pathway assigns UniProtKB:P06721 activity to the enzymatic step represented by RHEA:43021; this is a component step when the EC definition is an overall reaction."", ""source_locator"": ""Pathway/reaction-layout; Reaction/enzymatic-reaction and component-reaction relationships""}, {""quote"": ""Cloning, purification, and characterization of beta-cystathionase from Escherichia coli."", ""reference_id"": ""PMID:7049234"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""id"": ""MetaCyc:HOMOSER-METSYN-PWY"", ""source_sha256"": ""e117ce01268a3394bb06a1386ed067b0cef09c168cd9c64a92996c925b01acbd"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-methionine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HOMOSER-METSYN-PWY&detail=full""}, {""citation"": ""Dwivedi et al., Biochemistry, 1982"", ""id"": ""PMID:7049234"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/7049234/""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-030_947b5ab8efbe	EC:2.1.1.13	pathwaymech:catalyzes	RHEA:11173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11731805|RHEA:11172		"[{""reference_id"": ""RHEA:11172"", ""source_assertion"": ""Rhea associates EC:2.1.1.13 with the reaction family containing RHEA:11173."", ""source_locator"": ""rh:ec""}, {""quote"": ""Domain alternation switches B(12)-dependent methionine synthase to the activation conformation."", ""reference_id"": ""PMID:11731805"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Bandarian et al., Nature Structural Biology, 2002"", ""id"": ""PMID:11731805"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/11731805/""}, {""id"": ""RHEA:11172"", ""source_version"": ""139"", ""title"": ""Rhea cobalamin-dependent methionine synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/11172""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-031_e8076f4e0fad	EC:2.1.1.14	pathwaymech:catalyzes	RHEA:21197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:8823155|RHEA:21196		"[{""reference_id"": ""RHEA:21196"", ""source_assertion"": ""Rhea associates EC:2.1.1.14 with the reaction family containing RHEA:21197."", ""source_locator"": ""rh:ec""}, {""quote"": ""Cobalamin-independent methionine synthase from Escherichia coli: a zinc metalloenzyme."", ""reference_id"": ""PMID:8823155"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Gonzalez et al., Biochemistry, 1996"", ""id"": ""PMID:8823155"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/8823155/""}, {""id"": ""RHEA:21196"", ""source_version"": ""139"", ""title"": ""Rhea cobalamin-independent methionine synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/21196""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-032_5239d43d167d	RHEA:20398	pathwaymech:precedes	RHEA:43021	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HOMOSER-METSYN-PWY		"[{""reference_id"": ""MetaCyc:HOMOSER-METSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:20398 before RHEA:43021 in this pathway. Shared intermediate: CHEBI:58161."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:HOMOSER-METSYN-PWY"", ""source_sha256"": ""e117ce01268a3394bb06a1386ed067b0cef09c168cd9c64a92996c925b01acbd"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-methionine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HOMOSER-METSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-033_58688701771f	RHEA:22009	pathwaymech:precedes	RHEA:20398	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HOMOSER-METSYN-PWY		"[{""reference_id"": ""MetaCyc:HOMOSER-METSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:22009 before RHEA:20398 in this pathway. Shared intermediate: CHEBI:57661."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:HOMOSER-METSYN-PWY"", ""source_sha256"": ""e117ce01268a3394bb06a1386ed067b0cef09c168cd9c64a92996c925b01acbd"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-methionine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HOMOSER-METSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-034_052eecee5ba3	RHEA:40668	pathwaymech:precedes	RHEA:40672	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HOMOSER-METSYN-PWY		"[{""reference_id"": ""MetaCyc:HOMOSER-METSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:40668 before RHEA:40672 in this pathway. Shared intermediate: CHEBI:44400."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:HOMOSER-METSYN-PWY"", ""source_sha256"": ""e117ce01268a3394bb06a1386ed067b0cef09c168cd9c64a92996c925b01acbd"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-methionine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HOMOSER-METSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-035_e3fca9b06f42	RHEA:43021	pathwaymech:precedes	RHEA:11173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HOMOSER-METSYN-PWY		"[{""reference_id"": ""MetaCyc:HOMOSER-METSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:43021 before RHEA:11173 in this pathway. Shared intermediate: CHEBI:58199."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:HOMOSER-METSYN-PWY"", ""source_sha256"": ""e117ce01268a3394bb06a1386ed067b0cef09c168cd9c64a92996c925b01acbd"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-methionine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HOMOSER-METSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-036_e2749e9d35e2	RHEA:43021	pathwaymech:precedes	RHEA:21197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HOMOSER-METSYN-PWY		"[{""reference_id"": ""MetaCyc:HOMOSER-METSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:43021 before RHEA:21197 in this pathway. Shared intermediate: CHEBI:58199."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:HOMOSER-METSYN-PWY"", ""source_sha256"": ""e117ce01268a3394bb06a1386ed067b0cef09c168cd9c64a92996c925b01acbd"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-methionine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HOMOSER-METSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-037_ebd6043a9c4e	RHEA:43021	pathwaymech:precedes	RHEA:40668	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HOMOSER-METSYN-PWY		"[{""reference_id"": ""MetaCyc:HOMOSER-METSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:43021 before RHEA:40668 in this pathway. Shared intermediate: CHEBI:76565."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:HOMOSER-METSYN-PWY"", ""source_sha256"": ""e117ce01268a3394bb06a1386ed067b0cef09c168cd9c64a92996c925b01acbd"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-methionine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HOMOSER-METSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-038_b1e82cc0f345	UniProtKB:P00935	pathwaymech:enables	RHEA:20398	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00935		"[{""reference_id"": ""UniProtKB:P00935"", ""source_assertion"": ""UniProt annotates UniProtKB:P00935 with catalytic activity for the reaction family of RHEA:20398. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00935"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00935 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00935.json""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-039_74a520c6336a	UniProtKB:P00935	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00935		"[{""reference_id"": ""UniProtKB:P00935"", ""source_assertion"": ""UniProt locates UniProtKB:P00935 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P00935"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00935 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00935.json""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-040_e65de61a81d9	UniProtKB:P00935	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00935		"[{""reference_id"": ""UniProtKB:P00935"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P00935 (evidence: ECO:0000269). Binds 1 pyridoxal phosphate per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P00935"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00935 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00935.json""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-041_6cc794b78582	UniProtKB:P07623	pathwaymech:enables	RHEA:22009	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07623		"[{""reference_id"": ""UniProtKB:P07623"", ""source_assertion"": ""UniProt annotates UniProtKB:P07623 with catalytic activity for the reaction family of RHEA:22009. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P07623"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P07623 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07623.json""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-042_40f44b9c50ab	UniProtKB:P07623	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07623		"[{""reference_id"": ""UniProtKB:P07623"", ""source_assertion"": ""UniProt locates UniProtKB:P07623 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255, ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P07623"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P07623 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07623.json""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-043_740124855d20	UniProtKB:P0AF93	pathwaymech:enables	RHEA:40672	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF93		"[{""reference_id"": ""UniProtKB:P0AF93"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AF93 with catalytic activity for the reaction family of RHEA:40672. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AF93"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AF93 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF93.json""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-044_6b4c54c0e00e	UniProtKB:P0AF93	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF93		"[{""reference_id"": ""UniProtKB:P0AF93"", ""source_assertion"": ""UniProt locates UniProtKB:P0AF93 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0AF93"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AF93 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF93.json""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-045_7a5228ef24e1	UniProtKB:P13009	pathwaymech:enables	RHEA:11173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P13009		"[{""reference_id"": ""UniProtKB:P13009"", ""source_assertion"": ""UniProt annotates UniProtKB:P13009 with catalytic activity for the reaction family of RHEA:11173. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P13009"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P13009 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P13009.json""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-046_624e23541dad	UniProtKB:P13009	pathwaymech:has_cofactor	CHEBI:28115	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P13009		"[{""reference_id"": ""UniProtKB:P13009"", ""source_assertion"": ""UniProt lists CHEBI:28115 as a cofactor of UniProtKB:P13009 (evidence: ECO:0000269). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P13009"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P13009 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P13009.json""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-047_4d9442e20e5b	UniProtKB:P13009	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P13009		"[{""reference_id"": ""UniProtKB:P13009"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P13009 (evidence: ECO:0000269). Binds 1 zinc ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P13009"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P13009 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P13009.json""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-048_397a183b2b24	UniProtKB:P25665	pathwaymech:enables	RHEA:21197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P25665		"[{""reference_id"": ""UniProtKB:P25665"", ""source_assertion"": ""UniProt annotates UniProtKB:P25665 with catalytic activity for the reaction family of RHEA:21197. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P25665"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P25665 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P25665.json""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_edge-049_6891a7aee297	UniProtKB:P25665	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P25665		"[{""reference_id"": ""UniProtKB:P25665"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P25665 (evidence: ECO:0000255). Binds 1 zinc ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P25665"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P25665 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P25665.json""}]"	""
pathwaymech:MetaCyc_HOMOSER-METSYN-PWY_cofactor-34066b59b98c_ef4d1448ce74	UniProtKB:P06721	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06721	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3307782); ECO:0000269 (PubMed:7049234); ECO:0000269 (PubMed:8566238)	"[{""reference_id"": ""UniProtKB:P06721"", ""source_assertion"": ""UniProtKB:P06721 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/2/comments/0/cofactors/0""}]"	"[{""id"": ""UniProtKB:P06721"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB E. coli cystathionine beta-lyase MetC"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06721.json""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-001_30a5baeb4e65	CHEBI:29985	pathwaymech:consumes	RHEA:24293	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24293		"[{""reference_id"": ""RHEA:24293"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the substrates side of RHEA:24293 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24293']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24293"", ""source_version"": ""139"", ""title"": ""Rhea N-acetyl-L-glutamate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24293""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-002_ed969cce5272	CHEBI:57288	pathwaymech:consumes	RHEA:24293	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24293		"[{""reference_id"": ""RHEA:24293"", ""source_assertion"": ""Rhea lists CHEBI:57288 on the substrates side of RHEA:24293 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24293']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24293"", ""source_version"": ""139"", ""title"": ""Rhea N-acetyl-L-glutamate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24293""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-003_e83860896f9c	RHEA:24293	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24293		"[{""reference_id"": ""RHEA:24293"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:24293 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24293']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24293"", ""source_version"": ""139"", ""title"": ""Rhea N-acetyl-L-glutamate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24293""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-004_b99c2a72cb2e	RHEA:24293	pathwaymech:produces	CHEBI:44337	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24293		"[{""reference_id"": ""RHEA:24293"", ""source_assertion"": ""Rhea lists CHEBI:44337 on the products side of RHEA:24293 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24293']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24293"", ""source_version"": ""139"", ""title"": ""Rhea N-acetyl-L-glutamate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24293""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-005_554a163fce57	RHEA:24293	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24293		"[{""reference_id"": ""RHEA:24293"", ""source_assertion"": ""Rhea lists CHEBI:57287 on the products side of RHEA:24293 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24293']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24293"", ""source_version"": ""139"", ""title"": ""Rhea N-acetyl-L-glutamate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24293""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-006_f985d66eeafd	CHEBI:30616	pathwaymech:consumes	RHEA:14630	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14630		"[{""reference_id"": ""RHEA:14630"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:14630 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14630']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14630"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamyl 5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14630""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-007_997c4faa20df	CHEBI:44337	pathwaymech:consumes	RHEA:14630	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14630		"[{""reference_id"": ""RHEA:14630"", ""source_assertion"": ""Rhea lists CHEBI:44337 on the substrates side of RHEA:14630 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14630']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14630"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamyl 5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14630""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-008_1143a2117929	RHEA:14630	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14630		"[{""reference_id"": ""RHEA:14630"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:14630 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14630']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14630"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamyl 5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14630""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-009_543c2df9ecdc	RHEA:14630	pathwaymech:produces	CHEBI:57936	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14630		"[{""reference_id"": ""RHEA:14630"", ""source_assertion"": ""Rhea lists CHEBI:57936 on the products side of RHEA:14630 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14630']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14630"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamyl 5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14630""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-010_447efca76ac6	CHEBI:15378	pathwaymech:consumes	RHEA:21590	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21590		"[{""reference_id"": ""RHEA:21590"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:21590 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21590']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21590"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamate 5-semialdehyde-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21590""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-011_4f797db51cd0	CHEBI:57783	pathwaymech:consumes	RHEA:21590	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21590		"[{""reference_id"": ""RHEA:21590"", ""source_assertion"": ""Rhea lists CHEBI:57783 on the substrates side of RHEA:21590 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21590']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21590"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamate 5-semialdehyde-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21590""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-012_5ffdba6d7391	CHEBI:57936	pathwaymech:consumes	RHEA:21590	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21590		"[{""reference_id"": ""RHEA:21590"", ""source_assertion"": ""Rhea lists CHEBI:57936 on the substrates side of RHEA:21590 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21590']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21590"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamate 5-semialdehyde-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21590""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-013_fb758898e87b	RHEA:21590	pathwaymech:produces	CHEBI:29123	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21590		"[{""reference_id"": ""RHEA:21590"", ""source_assertion"": ""Rhea lists CHEBI:29123 on the products side of RHEA:21590 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21590']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21590"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamate 5-semialdehyde-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21590""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-014_fd590907916f	RHEA:21590	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21590		"[{""reference_id"": ""RHEA:21590"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:21590 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21590']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21590"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamate 5-semialdehyde-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21590""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-015_7db316076c6c	RHEA:21590	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21590		"[{""reference_id"": ""RHEA:21590"", ""source_assertion"": ""Rhea lists CHEBI:58349 on the products side of RHEA:21590 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21590']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21590"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamate 5-semialdehyde-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/21590""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-016_a70406b4a367	CHEBI:29123	pathwaymech:consumes	RHEA:18051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18051		"[{""reference_id"": ""RHEA:18051"", ""source_assertion"": ""Rhea lists CHEBI:29123 on the substrates side of RHEA:18051 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18051']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18051"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-acetyl-L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18051""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-017_f8e2af0cfbdf	CHEBI:29985	pathwaymech:consumes	RHEA:18051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18051		"[{""reference_id"": ""RHEA:18051"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the substrates side of RHEA:18051 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18051']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18051"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-acetyl-L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18051""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-018_119ea2912edc	RHEA:18051	pathwaymech:produces	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18051		"[{""reference_id"": ""RHEA:18051"", ""source_assertion"": ""Rhea lists CHEBI:16810 on the products side of RHEA:18051 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18051']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18051"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-acetyl-L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18051""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-019_2830db460936	RHEA:18051	pathwaymech:produces	CHEBI:57805	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18051		"[{""reference_id"": ""RHEA:18051"", ""source_assertion"": ""Rhea lists CHEBI:57805 on the products side of RHEA:18051 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18051']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18051"", ""source_version"": ""139"", ""title"": ""Rhea N(2)-acetyl-L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18051""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-020_aa1766236d25	CHEBI:15377	pathwaymech:consumes	RHEA:15942	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15942		"[{""reference_id"": ""RHEA:15942"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:15942 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15942']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15942"", ""source_version"": ""139"", ""title"": ""Rhea L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15942""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-021_797f11ac65e9	CHEBI:57805	pathwaymech:consumes	RHEA:15942	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15942		"[{""reference_id"": ""RHEA:15942"", ""source_assertion"": ""Rhea lists CHEBI:57805 on the substrates side of RHEA:15942 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15942']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15942"", ""source_version"": ""139"", ""title"": ""Rhea L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15942""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-022_108be9cf1787	RHEA:15942	pathwaymech:produces	CHEBI:30089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15942		"[{""reference_id"": ""RHEA:15942"", ""source_assertion"": ""Rhea lists CHEBI:30089 on the products side of RHEA:15942 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15942']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15942"", ""source_version"": ""139"", ""title"": ""Rhea L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15942""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-023_ce519df956ca	RHEA:15942	pathwaymech:produces	CHEBI:46911	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15942		"[{""reference_id"": ""RHEA:15942"", ""source_assertion"": ""Rhea lists CHEBI:46911 on the products side of RHEA:15942 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15942']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15942"", ""source_version"": ""139"", ""title"": ""Rhea L-ornithine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15942""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-024_33b6587b4c0a	EC:2.3.1.1	pathwaymech:catalyzes	RHEA:24293	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24292		"[{""reference_id"": ""RHEA:24292"", ""source_assertion"": ""Rhea associates EC:2.3.1.1 with the reaction family containing RHEA:24293."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:24292"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/24292""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-025_a61a1026b526	EC:2.7.2.8	pathwaymech:catalyzes	RHEA:14630	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14629		"[{""reference_id"": ""RHEA:14629"", ""source_assertion"": ""Rhea associates EC:2.7.2.8 with the reaction family containing RHEA:14630."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:14629"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamate kinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/14629""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-026_e80b55d3a334	EC:1.2.1.38	pathwaymech:catalyzes	RHEA:21590	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21588		"[{""reference_id"": ""RHEA:21588"", ""source_assertion"": ""Rhea associates EC:1.2.1.38 with the reaction family containing RHEA:21590."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:21588"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglutamyl-phosphate reductase reaction"", ""url"": ""https://www.rhea-db.org/rhea/21588""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-027_d4afa4be5697	EC:2.6.1.11	pathwaymech:catalyzes	RHEA:18051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18049		"[{""reference_id"": ""RHEA:18049"", ""source_assertion"": ""Rhea associates EC:2.6.1.11 with the reaction family containing RHEA:18051."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:18049"", ""source_version"": ""139"", ""title"": ""Rhea acetylornithine aminotransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/18049""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-028_28d025aeb28f	EC:3.5.1.16	pathwaymech:catalyzes	RHEA:15942	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15941		"[{""reference_id"": ""RHEA:15941"", ""source_assertion"": ""Rhea associates EC:3.5.1.16 with the reaction family containing RHEA:15942."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:15941"", ""source_version"": ""139"", ""title"": ""Rhea acetylornithine deacetylase reaction"", ""url"": ""https://www.rhea-db.org/rhea/15941""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-029_57c859e7568f	RHEA:14630	pathwaymech:precedes	RHEA:21590	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLUTORN-PWY		"[{""reference_id"": ""MetaCyc:GLUTORN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:14630 before RHEA:21590 in this pathway. Shared intermediate: CHEBI:57936."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GLUTORN-PWY"", ""source_sha256"": ""717cb07e72c85572038477c4130f22fa16d964161fc7e82dc069eb9c4a057de2"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-ornithine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLUTORN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-030_00ae64ea9c37	RHEA:18051	pathwaymech:precedes	RHEA:15942	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLUTORN-PWY		"[{""reference_id"": ""MetaCyc:GLUTORN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:18051 before RHEA:15942 in this pathway. Shared intermediate: CHEBI:57805."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GLUTORN-PWY"", ""source_sha256"": ""717cb07e72c85572038477c4130f22fa16d964161fc7e82dc069eb9c4a057de2"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-ornithine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLUTORN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-031_25a8d9f35cf2	RHEA:21590	pathwaymech:precedes	RHEA:18051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLUTORN-PWY		"[{""reference_id"": ""MetaCyc:GLUTORN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:21590 before RHEA:18051 in this pathway. Shared intermediate: CHEBI:29123."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GLUTORN-PWY"", ""source_sha256"": ""717cb07e72c85572038477c4130f22fa16d964161fc7e82dc069eb9c4a057de2"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-ornithine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLUTORN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-032_33fa1ec70062	RHEA:24293	pathwaymech:precedes	RHEA:14630	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLUTORN-PWY		"[{""reference_id"": ""MetaCyc:GLUTORN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:24293 before RHEA:14630 in this pathway. Shared intermediate: CHEBI:44337."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GLUTORN-PWY"", ""source_sha256"": ""717cb07e72c85572038477c4130f22fa16d964161fc7e82dc069eb9c4a057de2"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-ornithine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLUTORN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-033_1bbaa4c4ae22	UniProtKB:P0A6C5	pathwaymech:enables	RHEA:24293	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6C5		"[{""reference_id"": ""UniProtKB:P0A6C5"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A6C5 with catalytic activity for the reaction family of RHEA:24293. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A6C5"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6C5 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6C5.json""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-034_54b2886400ad	CHEBI:32682	pathwaymech:inhibits	UniProtKB:P0A6C5	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6C5		"[{""reference_id"": ""UniProtKB:P0A6C5"", ""source_assertion"": ""UniProt activity-regulation annotation: Feedback inhibition by L-arginine"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P0A6C5"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6C5 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6C5.json""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-035_487c68152648	UniProtKB:P0A6C5	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6C5		"[{""reference_id"": ""UniProtKB:P0A6C5"", ""source_assertion"": ""UniProt locates UniProtKB:P0A6C5 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A6C5"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6C5 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6C5.json""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-036_f95b3f59bfc3	UniProtKB:P0A6C8	pathwaymech:enables	RHEA:14630	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6C8		"[{""reference_id"": ""UniProtKB:P0A6C8"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A6C8 with catalytic activity for the reaction family of RHEA:14630. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A6C8"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6C8 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6C8.json""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-037_60dd80a9c2b3	UniProtKB:P0A6C8	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6C8		"[{""reference_id"": ""UniProtKB:P0A6C8"", ""source_assertion"": ""UniProt locates UniProtKB:P0A6C8 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A6C8"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6C8 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6C8.json""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-038_b64e033fe680	UniProtKB:P11446	pathwaymech:enables	RHEA:21590	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P11446		"[{""reference_id"": ""UniProtKB:P11446"", ""source_assertion"": ""UniProt annotates UniProtKB:P11446 with catalytic activity for the reaction family of RHEA:21590. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P11446"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P11446 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P11446.json""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-039_510f4a948a68	UniProtKB:P11446	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P11446		"[{""reference_id"": ""UniProtKB:P11446"", ""source_assertion"": ""UniProt locates UniProtKB:P11446 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P11446"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P11446 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P11446.json""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-040_9ac46937b0d9	UniProtKB:P18335	pathwaymech:enables	RHEA:18051	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P18335		"[{""reference_id"": ""UniProtKB:P18335"", ""source_assertion"": ""UniProt annotates UniProtKB:P18335 with catalytic activity for the reaction family of RHEA:18051. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P18335"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P18335 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P18335.json""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-041_ea1a225ef1d2	UniProtKB:P18335	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P18335		"[{""reference_id"": ""UniProtKB:P18335"", ""source_assertion"": ""UniProt locates UniProtKB:P18335 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255, ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P18335"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P18335 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P18335.json""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-042_a3195ec55d98	UniProtKB:P18335	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P18335		"[{""reference_id"": ""UniProtKB:P18335"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P18335 (evidence: ECO:0000255, ECO:0000305). Binds 1 pyridoxal phosphate per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P18335"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P18335 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P18335.json""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-043_abb60447b2c4	UniProtKB:P23908	pathwaymech:enables	RHEA:15942	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23908		"[{""reference_id"": ""UniProtKB:P23908"", ""source_assertion"": ""UniProt annotates UniProtKB:P23908 with catalytic activity for the reaction family of RHEA:15942. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P23908"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P23908 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23908.json""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-044_2350490e3e98	UniProtKB:P23908	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23908		"[{""reference_id"": ""UniProtKB:P23908"", ""source_assertion"": ""UniProt locates UniProtKB:P23908 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255, ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P23908"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P23908 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23908.json""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-045_0ac1db7a59ca	UniProtKB:P23908	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23908		"[{""reference_id"": ""UniProtKB:P23908"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P23908 (evidence: ECO:0000255, ECO:0000269). Binds 2 Zn(2+) or Co(2+) ions per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P23908"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P23908 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23908.json""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-046_7f3880e8d77c	UniProtKB:P23908	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23908		"[{""reference_id"": ""UniProtKB:P23908"", ""source_assertion"": ""UniProt lists CHEBI:48828 as a cofactor of UniProtKB:P23908 (evidence: ECO:0000255, ECO:0000269). Binds 2 Zn(2+) or Co(2+) ions per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P23908"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P23908 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23908.json""}]"	""
pathwaymech:MetaCyc_GLUTORN-PWY_edge-047_5d811b6165c5	UniProtKB:P23908	pathwaymech:has_cofactor	CHEBI:57925	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23908		"[{""reference_id"": ""UniProtKB:P23908"", ""source_assertion"": ""UniProt lists CHEBI:57925 as a cofactor of UniProtKB:P23908 (evidence: ECO:0000255). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P23908"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P23908 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23908.json""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-001_a89dffdfa1f1	CHEBI:29748	pathwaymech:consumes	RHEA:13898	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13898		"[{""reference_id"": ""RHEA:13898"", ""source_assertion"": ""Rhea lists CHEBI:29748 on the substrates side of RHEA:13898 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13898']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13898"", ""source_version"": ""139"", ""title"": ""Rhea prephenate-forming chorismate mutase direction"", ""url"": ""https://www.rhea-db.org/rhea/13898""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-002_635b4801607b	RHEA:13898	pathwaymech:produces	CHEBI:29934	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13898		"[{""reference_id"": ""RHEA:13898"", ""source_assertion"": ""Rhea lists CHEBI:29934 on the products side of RHEA:13898 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13898']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13898"", ""source_version"": ""139"", ""title"": ""Rhea prephenate-forming chorismate mutase direction"", ""url"": ""https://www.rhea-db.org/rhea/13898""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-003_477b733d3a55	CHEBI:15378	pathwaymech:consumes	RHEA:21649	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21649		"[{""reference_id"": ""RHEA:21649"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:21649 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21649']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21649"", ""source_version"": ""139"", ""title"": ""Rhea phenylpyruvate-forming prephenate dehydratase direction"", ""url"": ""https://www.rhea-db.org/rhea/21649""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-004_a1a5536a0af7	CHEBI:29934	pathwaymech:consumes	RHEA:21649	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21649		"[{""reference_id"": ""RHEA:21649"", ""source_assertion"": ""Rhea lists CHEBI:29934 on the substrates side of RHEA:21649 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21649']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21649"", ""source_version"": ""139"", ""title"": ""Rhea phenylpyruvate-forming prephenate dehydratase direction"", ""url"": ""https://www.rhea-db.org/rhea/21649""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-005_e2f6b907aced	RHEA:21649	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21649		"[{""reference_id"": ""RHEA:21649"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:21649 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21649']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21649"", ""source_version"": ""139"", ""title"": ""Rhea phenylpyruvate-forming prephenate dehydratase direction"", ""url"": ""https://www.rhea-db.org/rhea/21649""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-006_e9512448a1a5	RHEA:21649	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21649		"[{""reference_id"": ""RHEA:21649"", ""source_assertion"": ""Rhea lists CHEBI:16526 on the products side of RHEA:21649 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21649']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21649"", ""source_version"": ""139"", ""title"": ""Rhea phenylpyruvate-forming prephenate dehydratase direction"", ""url"": ""https://www.rhea-db.org/rhea/21649""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-007_b153893e07c6	RHEA:21649	pathwaymech:produces	CHEBI:18005	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21649		"[{""reference_id"": ""RHEA:21649"", ""source_assertion"": ""Rhea lists CHEBI:18005 on the products side of RHEA:21649 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21649']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21649"", ""source_version"": ""139"", ""title"": ""Rhea phenylpyruvate-forming prephenate dehydratase direction"", ""url"": ""https://www.rhea-db.org/rhea/21649""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-008_7795f028c7bf	CHEBI:18005	pathwaymech:consumes	RHEA:25154	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25154		"[{""reference_id"": ""RHEA:25154"", ""source_assertion"": ""Rhea lists CHEBI:18005 on the substrates side of RHEA:25154 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25154']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25154"", ""source_version"": ""139"", ""title"": ""Rhea L-phenylalanine-forming aminotransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/25154""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-009_c41ff43591a0	CHEBI:29985	pathwaymech:consumes	RHEA:25154	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25154		"[{""reference_id"": ""RHEA:25154"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the substrates side of RHEA:25154 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25154']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25154"", ""source_version"": ""139"", ""title"": ""Rhea L-phenylalanine-forming aminotransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/25154""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-010_1a7b7da60ccd	RHEA:25154	pathwaymech:produces	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25154		"[{""reference_id"": ""RHEA:25154"", ""source_assertion"": ""Rhea lists CHEBI:16810 on the products side of RHEA:25154 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25154']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25154"", ""source_version"": ""139"", ""title"": ""Rhea L-phenylalanine-forming aminotransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/25154""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-011_511affdbc68a	RHEA:25154	pathwaymech:produces	CHEBI:58095	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25154		"[{""reference_id"": ""RHEA:25154"", ""source_assertion"": ""Rhea lists CHEBI:58095 on the products side of RHEA:25154 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25154']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25154"", ""source_version"": ""139"", ""title"": ""Rhea L-phenylalanine-forming aminotransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/25154""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-012_7718f1cec7d2	EC:5.4.99.5	pathwaymech:catalyzes	RHEA:13898	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:4261395|RHEA:13897		"[{""reference_id"": ""RHEA:13897"", ""source_assertion"": ""Rhea associates EC:5.4.99.5 with the reaction family containing RHEA:13898."", ""source_locator"": ""rh:ec""}, {""quote"": ""Chorismate mutase-prephenate dehydratase from Escherichia coli K-12. II. Kinetic properties."", ""reference_id"": ""PMID:4261395"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Dopheide et al., Journal of Biological Chemistry, 1972"", ""id"": ""PMID:4261395"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/4261395/""}, {""id"": ""RHEA:13897"", ""source_version"": ""139"", ""title"": ""Rhea chorismate mutase reaction"", ""url"": ""https://www.rhea-db.org/rhea/13897""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-013_e6082515dfaa	EC:4.2.1.51	pathwaymech:catalyzes	RHEA:21649	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:4261395|RHEA:21648		"[{""reference_id"": ""RHEA:21648"", ""source_assertion"": ""Rhea associates EC:4.2.1.51 with the reaction family containing RHEA:21649."", ""source_locator"": ""rh:ec""}, {""quote"": ""Chorismate mutase-prephenate dehydratase from Escherichia coli K-12. II. Kinetic properties."", ""reference_id"": ""PMID:4261395"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Dopheide et al., Journal of Biological Chemistry, 1972"", ""id"": ""PMID:4261395"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/4261395/""}, {""id"": ""RHEA:21648"", ""source_version"": ""139"", ""title"": ""Rhea prephenate dehydratase reaction"", ""url"": ""https://www.rhea-db.org/rhea/21648""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-014_831ec74c8a62	EC:2.6.1.57	pathwaymech:catalyzes	RHEA:25154	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:236311|RHEA:25152		"[{""reference_id"": ""RHEA:25152"", ""source_assertion"": ""Rhea associates EC:2.6.1.57 with the reaction family containing RHEA:25154."", ""source_locator"": ""rh:ec""}, {""quote"": ""Multispecific aspartate and aromatic amino acid aminotransferases in Escherichia coli."", ""reference_id"": ""PMID:236311"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Mavrides and Orr, Journal of Biological Chemistry, 1975"", ""id"": ""PMID:236311"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/236311/""}, {""id"": ""RHEA:25152"", ""source_version"": ""139"", ""title"": ""Rhea L-phenylalanine aminotransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/25152""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-015_521f612ba5f2	RHEA:13898	pathwaymech:precedes	RHEA:21649	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PHESYN		"[{""reference_id"": ""MetaCyc:PHESYN"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:13898 before RHEA:21649 in this pathway. Shared intermediate: CHEBI:29934."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PHESYN"", ""source_sha256"": ""84ff59822b53dd46b140ee835bfbc647b445be0db048e321725545e268397d32"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-phenylalanine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PHESYN&detail=full""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-016_2091b036b5a2	RHEA:21649	pathwaymech:precedes	RHEA:25154	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PHESYN		"[{""reference_id"": ""MetaCyc:PHESYN"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:21649 before RHEA:25154 in this pathway. Shared intermediate: CHEBI:18005."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PHESYN"", ""source_sha256"": ""84ff59822b53dd46b140ee835bfbc647b445be0db048e321725545e268397d32"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-phenylalanine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PHESYN&detail=full""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-017_062ff3374e39	UniProtKB:P07023	pathwaymech:enables	RHEA:13898	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07023		"[{""reference_id"": ""UniProtKB:P07023"", ""source_assertion"": ""UniProt annotates UniProtKB:P07023 with catalytic activity for the reaction family of RHEA:13898. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P07023"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P07023 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07023.json""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-018_d82598d39dcc	UniProtKB:P07023	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07023		"[{""reference_id"": ""UniProtKB:P07023"", ""source_assertion"": ""UniProt locates UniProtKB:P07023 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P07023"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P07023 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07023.json""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-019_f3c3c5ead703	UniProtKB:P0A9J8	pathwaymech:enables	RHEA:13898	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9J8		"[{""reference_id"": ""UniProtKB:P0A9J8"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A9J8 with catalytic activity for the reaction family of RHEA:13898. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A9J8"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9J8 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9J8.json""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-020_92a282024187	UniProtKB:P0A9J8	pathwaymech:enables	RHEA:21649	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9J8		"[{""reference_id"": ""UniProtKB:P0A9J8"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A9J8 with catalytic activity for the reaction family of RHEA:21649. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A9J8"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9J8 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9J8.json""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-021_6681c89c48aa	CHEBI:58095	pathwaymech:inhibits	UniProtKB:P0A9J8	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9J8		"[{""reference_id"": ""UniProtKB:P0A9J8"", ""source_assertion"": ""UniProt activity-regulation annotation: Both activities are inhibited by L-phenylalanine"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P0A9J8"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9J8 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9J8.json""}]"	""
pathwaymech:MetaCyc_PHESYN_edge-022_785f4924a0ed	UniProtKB:P0A9J8	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9J8		"[{""reference_id"": ""UniProtKB:P0A9J8"", ""source_assertion"": ""UniProt locates UniProtKB:P0A9J8 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A9J8"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9J8 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9J8.json""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-001_a64d73f4dec6	CHEBI:29985	pathwaymech:consumes	RHEA:14878	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14878		"[{""reference_id"": ""RHEA:14878"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the substrates side of RHEA:14878 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14878']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14878"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right glutamate 5-kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/14878""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-002_3fe96ad7d8c6	CHEBI:30616	pathwaymech:consumes	RHEA:14878	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14878		"[{""reference_id"": ""RHEA:14878"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:14878 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14878']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14878"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right glutamate 5-kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/14878""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-003_dce3692c7532	RHEA:14878	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14878		"[{""reference_id"": ""RHEA:14878"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:14878 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14878']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14878"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right glutamate 5-kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/14878""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-004_ca3a737af322	RHEA:14878	pathwaymech:produces	CHEBI:58274	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14878		"[{""reference_id"": ""RHEA:14878"", ""source_assertion"": ""Rhea lists CHEBI:58274 on the products side of RHEA:14878 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14878']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14878"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right glutamate 5-kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/14878""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-005_cb50a5d16f88	CHEBI:15378	pathwaymech:consumes	RHEA:19543	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19543		"[{""reference_id"": ""RHEA:19543"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:19543 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19543']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19543"", ""source_version"": ""139"", ""title"": ""Rhea L-glutamate 5-semialdehyde-producing direction"", ""url"": ""https://www.rhea-db.org/rhea/19543""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-006_52cf8059415f	CHEBI:57783	pathwaymech:consumes	RHEA:19543	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19543		"[{""reference_id"": ""RHEA:19543"", ""source_assertion"": ""Rhea lists CHEBI:57783 on the substrates side of RHEA:19543 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19543']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19543"", ""source_version"": ""139"", ""title"": ""Rhea L-glutamate 5-semialdehyde-producing direction"", ""url"": ""https://www.rhea-db.org/rhea/19543""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-007_a7322d366740	CHEBI:58274	pathwaymech:consumes	RHEA:19543	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19543		"[{""reference_id"": ""RHEA:19543"", ""source_assertion"": ""Rhea lists CHEBI:58274 on the substrates side of RHEA:19543 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19543']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19543"", ""source_version"": ""139"", ""title"": ""Rhea L-glutamate 5-semialdehyde-producing direction"", ""url"": ""https://www.rhea-db.org/rhea/19543""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-008_36812c1e6a3d	RHEA:19543	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19543		"[{""reference_id"": ""RHEA:19543"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:19543 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19543']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19543"", ""source_version"": ""139"", ""title"": ""Rhea L-glutamate 5-semialdehyde-producing direction"", ""url"": ""https://www.rhea-db.org/rhea/19543""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-009_2ab457a5b2b7	RHEA:19543	pathwaymech:produces	CHEBI:58066	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19543		"[{""reference_id"": ""RHEA:19543"", ""source_assertion"": ""Rhea lists CHEBI:58066 on the products side of RHEA:19543 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19543']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19543"", ""source_version"": ""139"", ""title"": ""Rhea L-glutamate 5-semialdehyde-producing direction"", ""url"": ""https://www.rhea-db.org/rhea/19543""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-010_f62a7aa2ab31	RHEA:19543	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19543		"[{""reference_id"": ""RHEA:19543"", ""source_assertion"": ""Rhea lists CHEBI:58349 on the products side of RHEA:19543 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19543']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19543"", ""source_version"": ""139"", ""title"": ""Rhea L-glutamate 5-semialdehyde-producing direction"", ""url"": ""https://www.rhea-db.org/rhea/19543""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-011_eb1277a2f8df	CHEBI:58066	pathwaymech:consumes	RHEA:28235	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28235		"[{""reference_id"": ""RHEA:28235"", ""source_assertion"": ""Rhea lists CHEBI:58066 on the substrates side of RHEA:28235 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28235']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28235"", ""source_version"": ""139"", ""title"": ""Rhea L-glutamate 5-semialdehyde cyclization direction"", ""url"": ""https://www.rhea-db.org/rhea/28235""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-012_f8bb924695af	RHEA:28235	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28235		"[{""reference_id"": ""RHEA:28235"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:28235 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28235']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28235"", ""source_version"": ""139"", ""title"": ""Rhea L-glutamate 5-semialdehyde cyclization direction"", ""url"": ""https://www.rhea-db.org/rhea/28235""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-013_5a10fec3b63f	RHEA:28235	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28235		"[{""reference_id"": ""RHEA:28235"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:28235 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28235']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28235"", ""source_version"": ""139"", ""title"": ""Rhea L-glutamate 5-semialdehyde cyclization direction"", ""url"": ""https://www.rhea-db.org/rhea/28235""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-014_f146f552f8d4	RHEA:28235	pathwaymech:produces	CHEBI:17388	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28235		"[{""reference_id"": ""RHEA:28235"", ""source_assertion"": ""Rhea lists CHEBI:17388 on the products side of RHEA:28235 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28235']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28235"", ""source_version"": ""139"", ""title"": ""Rhea L-glutamate 5-semialdehyde cyclization direction"", ""url"": ""https://www.rhea-db.org/rhea/28235""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-015_8dbd64815ea0	CHEBI:15378	pathwaymech:consumes	RHEA:14111	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14111		"[{""reference_id"": ""RHEA:14111"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:14111 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14111']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14111"", ""source_version"": ""139"", ""title"": ""Rhea L-proline-producing pyrroline-5-carboxylate reductase direction"", ""url"": ""https://www.rhea-db.org/rhea/14111""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-016_ae40dc9fd38b	CHEBI:17388	pathwaymech:consumes	RHEA:14111	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14111		"[{""reference_id"": ""RHEA:14111"", ""source_assertion"": ""Rhea lists CHEBI:17388 on the substrates side of RHEA:14111 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14111']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14111"", ""source_version"": ""139"", ""title"": ""Rhea L-proline-producing pyrroline-5-carboxylate reductase direction"", ""url"": ""https://www.rhea-db.org/rhea/14111""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-017_f6553bcda250	CHEBI:57783	pathwaymech:consumes	RHEA:14111	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14111		"[{""reference_id"": ""RHEA:14111"", ""source_assertion"": ""Rhea lists CHEBI:57783 on the substrates side of RHEA:14111 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14111']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14111"", ""source_version"": ""139"", ""title"": ""Rhea L-proline-producing pyrroline-5-carboxylate reductase direction"", ""url"": ""https://www.rhea-db.org/rhea/14111""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-018_6c02c30aae28	RHEA:14111	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14111		"[{""reference_id"": ""RHEA:14111"", ""source_assertion"": ""Rhea lists CHEBI:58349 on the products side of RHEA:14111 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14111']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14111"", ""source_version"": ""139"", ""title"": ""Rhea L-proline-producing pyrroline-5-carboxylate reductase direction"", ""url"": ""https://www.rhea-db.org/rhea/14111""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-019_3104506a9636	RHEA:14111	pathwaymech:produces	CHEBI:60039	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14111		"[{""reference_id"": ""RHEA:14111"", ""source_assertion"": ""Rhea lists CHEBI:60039 on the products side of RHEA:14111 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14111']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14111"", ""source_version"": ""139"", ""title"": ""Rhea L-proline-producing pyrroline-5-carboxylate reductase direction"", ""url"": ""https://www.rhea-db.org/rhea/14111""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-020_329df72308ed	EC:2.7.2.11	pathwaymech:catalyzes	RHEA:14878	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:6319365|RHEA:14877		"[{""reference_id"": ""RHEA:14877"", ""source_assertion"": ""Rhea associates EC:2.7.2.11 with the reaction family containing RHEA:14878."", ""source_locator"": ""rh:ec""}, {""quote"": ""gamma-Glutamyl kinase, the first enzyme of the proline biosynthetic pathway, was purified to homogeneity from an Escherichia coli strain resistant to the proline analog 3,4-dehydroproline."", ""reference_id"": ""PMID:6319365"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Smith et al., Journal of Bacteriology, 1984"", ""id"": ""PMID:6319365"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/6319365/""}, {""id"": ""RHEA:14877"", ""source_version"": ""139"", ""title"": ""Rhea glutamate 5-kinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/14877""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-021_d718c80d5e56	EC:1.2.1.41	pathwaymech:catalyzes	RHEA:19543	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:7035170|RHEA:19541		"[{""reference_id"": ""RHEA:19541"", ""source_assertion"": ""Rhea associates EC:1.2.1.41 with the reaction family containing RHEA:19543."", ""source_locator"": ""rh:ec""}, {""quote"": ""Glutamate-semialdehyde dehydrogenase, catalysing the reduction in vivo of gamma-glutamyl phosphate to glutamate 5-semialdehyde in the pathway of proline biosynthesis in Escherichia coli, has been purified to homogeneity."", ""reference_id"": ""PMID:7035170"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Hayzer and Leisinger, European Journal of Biochemistry, 1982"", ""id"": ""PMID:7035170"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/7035170/""}, {""id"": ""RHEA:19541"", ""source_version"": ""139"", ""title"": ""Rhea glutamate-5-semialdehyde dehydrogenase reaction"", ""url"": ""https://www.rhea-db.org/rhea/19541""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-022_eaec78b404a6	EC:1.5.1.2	pathwaymech:catalyzes	RHEA:14111	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:6296787|RHEA:14109		"[{""reference_id"": ""RHEA:14109"", ""source_assertion"": ""Rhea associates EC:1.5.1.2 with the reaction family containing RHEA:14111."", ""source_locator"": ""rh:ec""}, {""quote"": ""The sequence of the Escherichia coli proC gene which encodes for delta 1-pyrroline-5-carboxylate (PCA) reductase was determined."", ""reference_id"": ""PMID:6296787"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Deutch et al., Nucleic Acids Research, 1982"", ""id"": ""PMID:6296787"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/6296787/""}, {""id"": ""RHEA:14109"", ""source_version"": ""139"", ""title"": ""Rhea NADPH-dependent pyrroline-5-carboxylate reductase reaction"", ""url"": ""https://www.rhea-db.org/rhea/14109""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-023_3efc65f292d8	RHEA:14878	pathwaymech:precedes	RHEA:19543	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PROSYN-PWY		"[{""reference_id"": ""MetaCyc:PROSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:14878 before RHEA:19543 in this pathway. Shared intermediate: CHEBI:58274."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PROSYN-PWY"", ""source_sha256"": ""44e223be5f5d3eb20a712bae9260542959fadde61606b2023c8f9132a525e816"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-proline biosynthesis I (from L-glutamate) pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PROSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-024_6f6155eadf8f	RHEA:19543	pathwaymech:precedes	RHEA:28235	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PROSYN-PWY		"[{""reference_id"": ""MetaCyc:PROSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:19543 before RHEA:28235 in this pathway. Shared intermediate: CHEBI:58066."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PROSYN-PWY"", ""source_sha256"": ""44e223be5f5d3eb20a712bae9260542959fadde61606b2023c8f9132a525e816"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-proline biosynthesis I (from L-glutamate) pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PROSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-025_90c6f2edf7ce	RHEA:28235	pathwaymech:precedes	RHEA:14111	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PROSYN-PWY		"[{""reference_id"": ""MetaCyc:PROSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:28235 before RHEA:14111 in this pathway. Shared intermediate: CHEBI:17388."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PROSYN-PWY"", ""source_sha256"": ""44e223be5f5d3eb20a712bae9260542959fadde61606b2023c8f9132a525e816"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-proline biosynthesis I (from L-glutamate) pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PROSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-026_1dc5f2cf545c	UniProtKB:P07004	pathwaymech:enables	RHEA:19543	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07004		"[{""reference_id"": ""UniProtKB:P07004"", ""source_assertion"": ""UniProt annotates UniProtKB:P07004 with catalytic activity for the reaction family of RHEA:19543. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P07004"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P07004 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07004.json""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-027_59d2c3dbdc91	UniProtKB:P07004	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07004		"[{""reference_id"": ""UniProtKB:P07004"", ""source_assertion"": ""UniProt locates UniProtKB:P07004 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P07004"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P07004 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07004.json""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-028_c9cb01142b8e	UniProtKB:P0A7B5	pathwaymech:enables	RHEA:14878	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A7B5		"[{""reference_id"": ""UniProtKB:P0A7B5"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A7B5 with catalytic activity for the reaction family of RHEA:14878. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A7B5"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A7B5 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A7B5.json""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-029_b78b4524c7b7	CHEBI:60039	pathwaymech:inhibits	UniProtKB:P0A7B5	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A7B5		"[{""reference_id"": ""UniProtKB:P0A7B5"", ""source_assertion"": ""UniProt activity-regulation annotation: Inhibited by proline and ADP"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P0A7B5"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A7B5 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A7B5.json""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-030_a28c612dcab1	CHEBI:456216	pathwaymech:inhibits	UniProtKB:P0A7B5	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A7B5		"[{""reference_id"": ""UniProtKB:P0A7B5"", ""source_assertion"": ""UniProt activity-regulation annotation: Inhibited by proline and ADP"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P0A7B5"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A7B5 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A7B5.json""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-031_aeacf729b47a	UniProtKB:P0A7B5	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A7B5		"[{""reference_id"": ""UniProtKB:P0A7B5"", ""source_assertion"": ""UniProt locates UniProtKB:P0A7B5 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A7B5"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A7B5 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A7B5.json""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-032_22a71a08a402	UniProtKB:P0A9L8	pathwaymech:enables	RHEA:14111	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9L8		"[{""reference_id"": ""UniProtKB:P0A9L8"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A9L8 with catalytic activity for the reaction family of RHEA:14111. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A9L8"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9L8 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9L8.json""}]"	""
pathwaymech:MetaCyc_PROSYN-PWY_edge-033_b711f12f71aa	UniProtKB:P0A9L8	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9L8		"[{""reference_id"": ""UniProtKB:P0A9L8"", ""source_assertion"": ""UniProt locates UniProtKB:P0A9L8 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255, ECO:0000269."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A9L8"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9L8 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9L8.json""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-001_a5f3954b4248	gomodel:SPONTPRO-RXN	BFO:0000050	GO:0006562	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:SPONTPRO-RXN BFO:0000050 gomodel:YeastPathways_PROUT-PWY/YeastPathways_PROUT-PWY."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/0; endpoint types: /individuals/15/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-002_ce4e0ce54b16	gomodel:RXN-14116	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-14116 RO:0002234 gomodel:CHEBI_57945_RXN-14116."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/1; endpoint types: /individuals/13/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-003_61eb3eece51a	gomodel:RXN-14116	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-14116 RO:0002234 gomodel:CHEBI_15378_RXN-14116."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/2; endpoint types: /individuals/13/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-005_40a0b0081a64	SGD:S000004132	pathwaymech:enables	gomodel:RXN-14903	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-14903 RO:0002333 gomodel:YLR142W-MONOMER_RXN-14903_controller."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/4; endpoint types: /individuals/14/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-006_10f284e4949f	gomodel:SPONTPRO-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:SPONTPRO-RXN RO:0002233 gomodel:CHEBI_15378_SPONTPRO-RXN."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/5; endpoint types: /individuals/15/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-007_4a87988fde97	gomodel:RXN-14903	RO:0002234	CHEBI:17594	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-14903 RO:0002234 gomodel:CHEBI_17594_RXN-14903."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/6; endpoint types: /individuals/14/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-008_fe933b4fff26	gomodel:SPONTPRO-RXN	RO:0002233	CHEBI:17388	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:SPONTPRO-RXN RO:0002233 gomodel:CHEBI_17388_RXN-14903."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/7; endpoint types: /individuals/15/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-009_3d174b70ea72	gomodel:RXN-14116	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-14116 RO:0002233 gomodel:CHEBI_15377_RXN-14116."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/8; endpoint types: /individuals/13/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-010_dc834f518086	gomodel:SPONTPRO-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:SPONTPRO-RXN RO:0002233 gomodel:CHEBI_15377_SPONTPRO-RXN."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/9; endpoint types: /individuals/15/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-012_01d3d43b1892	gomodel:RXN-14116	BFO:0000050	GO:0006562	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-14116 BFO:0000050 gomodel:YeastPathways_PROUT-PWY/YeastPathways_PROUT-PWY."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/11; endpoint types: /individuals/13/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-013_4c2efb7b25dd	gomodel:SPONTPRO-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:SPONTPRO-RXN BFO:0000066 gomodel:reaction_SPONTPRO-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/12; endpoint types: /individuals/15/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-014_2b6d199587f1	gomodel:RXN-14903	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-14903 RO:0002234 gomodel:CHEBI_15378_RXN-14903."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/13; endpoint types: /individuals/14/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-015_e868573ff249	gomodel:RXN-14903	RO:0002233	CHEBI:60039	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-14903 RO:0002233 gomodel:CHEBI_60039_RXN-14903."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/14; endpoint types: /individuals/14/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-016_a54fbca63d42	gomodel:RXN-14903	RO:0002411	gomodel:RXN-14116	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-14903 RO:0002411 gomodel:RXN-14116."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/15; endpoint types: /individuals/14/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-017_09c7f51f00ef	SGD:S000001079	pathwaymech:enables	gomodel:RXN-14116	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-14116 RO:0002333 gomodel:YeastPathways_PROUT-PWY/6690711d00000539."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/16; endpoint types: /individuals/13/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-018_e42162db76d2	gomodel:RXN-14903	RO:0002233	CHEBI:36141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-14903 RO:0002233 gomodel:CHEBI_36141_RXN-14903."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/17; endpoint types: /individuals/14/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-019_b93bebda4111	gomodel:SPONTPRO-RXN	RO:0002234	CHEBI:58066	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:SPONTPRO-RXN RO:0002234 gomodel:CHEBI_58066_SPONTPRO-RXN."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/18; endpoint types: /individuals/15/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-020_9411c0c6d570	gomodel:RXN-14116	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-14116 RO:0002233 gomodel:CHEBI_57540_RXN-14116."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/19; endpoint types: /individuals/13/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-021_f5d1a17492e3	gomodel:RXN-14903	RO:0002234	CHEBI:17388	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-14903 RO:0002234 gomodel:CHEBI_17388_RXN-14903."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/20; endpoint types: /individuals/14/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-022_e3aa31bfe182	gomodel:RXN-14116	RO:0002234	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-14116 RO:0002234 gomodel:CHEBI_29985_RXN-14116."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/21; endpoint types: /individuals/13/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-023_7626d0f408d5	gomodel:RXN-14116	RO:0002233	CHEBI:58066	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-14116 RO:0002233 gomodel:CHEBI_58066_SPONTPRO-RXN."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/22; endpoint types: /individuals/13/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_edge-024_98fbfec05131	gomodel:RXN-14903	BFO:0000050	GO:0006562	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PROUT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN-14903 BFO:0000050 gomodel:YeastPathways_PROUT-PWY/YeastPathways_PROUT-PWY."", ""source_locator"": ""./YeastPathways_PROUT-PWY.json#/facts/23; endpoint types: /individuals/14/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PROUT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PROUT-PWY.json"", ""title"": ""GO-CAM L-proline degradation model YeastPathways_PROUT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_location-ea8376ae6a7e_55357ef4d93b	SGD:S000004132	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09368	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P09368"", ""source_assertion"": ""UniProtKB:P09368 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3256/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P09368"", ""source_assertion"": ""UniProtKB:P09368 has the exact SGD cross-reference SGD:S000004132."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3256/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P09368"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P09368 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_location-31f43829332d_b2dc41c5d78b	SGD:S000001079	RO:0001025	GO:0005743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07275	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11502169)	"[{""reference_id"": ""UniProtKB:P07275"", ""source_assertion"": ""UniProtKB:P07275 annotates location Mitochondrion inner membrane (SL-0168)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3249/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07275"", ""source_assertion"": ""UniProtKB:P07275 has the exact SGD cross-reference SGD:S000001079."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3249/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07275"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07275 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PROUT-PWY_cofactor-d310972850d8_4115436dd46d	SGD:S000004132	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09368	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P09368"", ""source_assertion"": ""UniProtKB:P09368 annotates CHEBI:57692 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3256/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P09368"", ""source_assertion"": ""UniProtKB:P09368 has the exact SGD cross-reference SGD:S000004132."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3256/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P09368"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P09368 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-001_f852ee1ea4b5	CHEBI:17897	pathwaymech:consumes	MetaCyc:RXN-15356	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-15356		"[{""reference_id"": ""MetaCyc:RXN-15356"", ""source_assertion"": ""MetaCyc assigns CHEBI:17897 consumes MetaCyc:RXN-15356 in the spontaneous rhamnulose cyclization."", ""source_locator"": ""Reaction[@frameid='RXN-15356']/left|right; native compound cross-references""}]"	"[{""id"": ""MetaCyc:RXN-15356"", ""source_sha256"": ""15b4a7a238f233f6f2bb18c6f6b7c3a0d1ec18f5976a22254184c50d94c25b08"", ""source_version"": ""22.5"", ""title"": ""MetaCyc:RXN-15356 authority record"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:RXN-15356&detail=full""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-002_fc7ef07fedbb	MetaCyc:RXN-15356	pathwaymech:produces	MetaCyc:CPD-16567	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-15356		"[{""reference_id"": ""MetaCyc:RXN-15356"", ""source_assertion"": ""MetaCyc assigns MetaCyc:RXN-15356 produces MetaCyc:CPD-16567 in the spontaneous rhamnulose cyclization."", ""source_locator"": ""Reaction[@frameid='RXN-15356']/left|right; native compound cross-references""}]"	"[{""id"": ""MetaCyc:RXN-15356"", ""source_sha256"": ""15b4a7a238f233f6f2bb18c6f6b7c3a0d1ec18f5976a22254184c50d94c25b08"", ""source_version"": ""22.5"", ""title"": ""MetaCyc:RXN-15356 authority record"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:RXN-15356&detail=full""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-003_57eeaa5849e4	CHEBI:17897	pathwaymech:consumes	RHEA:20118	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20118		"[{""reference_id"": ""RHEA:20118"", ""source_assertion"": ""Rhea lists CHEBI:17897 on the substrates side of RHEA:20118 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20118']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20118"", ""source_version"": ""139"", ""title"": ""Rhea L-rhamnulose-1-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/20118""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-004_0a65d5d57670	CHEBI:30616	pathwaymech:consumes	RHEA:20118	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20118		"[{""reference_id"": ""RHEA:20118"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:20118 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20118']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20118"", ""source_version"": ""139"", ""title"": ""Rhea L-rhamnulose-1-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/20118""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-005_a9899b90a0c5	RHEA:20118	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20118		"[{""reference_id"": ""RHEA:20118"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:20118 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20118']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20118"", ""source_version"": ""139"", ""title"": ""Rhea L-rhamnulose-1-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/20118""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-006_d0fcd8c9b2ba	RHEA:20118	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20118		"[{""reference_id"": ""RHEA:20118"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:20118 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20118']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20118"", ""source_version"": ""139"", ""title"": ""Rhea L-rhamnulose-1-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/20118""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-007_67f4ce25537e	RHEA:20118	pathwaymech:produces	CHEBI:58313	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20118		"[{""reference_id"": ""RHEA:20118"", ""source_assertion"": ""Rhea lists CHEBI:58313 on the products side of RHEA:20118 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20118']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20118"", ""source_version"": ""139"", ""title"": ""Rhea L-rhamnulose-1-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/20118""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-008_d20ef175ccbd	CHEBI:27907	pathwaymech:consumes	RHEA:25585	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25585		"[{""reference_id"": ""RHEA:25585"", ""source_assertion"": ""Rhea lists CHEBI:27907 on the substrates side of RHEA:25585 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25585']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25585"", ""source_version"": ""139"", ""title"": ""RHEA:25585 authority record"", ""url"": ""https://www.rhea-db.org/rhea/25585""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-009_a1cbb5f12321	RHEA:25585	pathwaymech:produces	CHEBI:27586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25585		"[{""reference_id"": ""RHEA:25585"", ""source_assertion"": ""Rhea lists CHEBI:27586 on the products side of RHEA:25585 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25585']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25585"", ""source_version"": ""139"", ""title"": ""RHEA:25585 authority record"", ""url"": ""https://www.rhea-db.org/rhea/25585""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-010_60dc5d8670eb	CHEBI:62346	pathwaymech:consumes	RHEA:23161	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23161		"[{""reference_id"": ""RHEA:23161"", ""source_assertion"": ""Rhea lists CHEBI:62346 on the substrates side of RHEA:23161 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23161']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23161"", ""source_version"": ""139"", ""title"": ""RHEA:23161 authority record"", ""url"": ""https://www.rhea-db.org/rhea/23161""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-011_3674df7f1280	RHEA:23161	pathwaymech:produces	CHEBI:17897	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23161		"[{""reference_id"": ""RHEA:23161"", ""source_assertion"": ""Rhea lists CHEBI:17897 on the products side of RHEA:23161 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23161']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23161"", ""source_version"": ""139"", ""title"": ""RHEA:23161 authority record"", ""url"": ""https://www.rhea-db.org/rhea/23161""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-012_ed5c5d7c80a0	CHEBI:58313	pathwaymech:consumes	RHEA:19690	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19690		"[{""reference_id"": ""RHEA:19690"", ""source_assertion"": ""Rhea lists CHEBI:58313 on the substrates side of RHEA:19690 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19690']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19690"", ""source_version"": ""139"", ""title"": ""RHEA:19690 authority record"", ""url"": ""https://www.rhea-db.org/rhea/19690""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-013_162efb354a12	RHEA:19690	pathwaymech:produces	CHEBI:18041	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19690		"[{""reference_id"": ""RHEA:19690"", ""source_assertion"": ""Rhea lists CHEBI:18041 on the products side of RHEA:19690 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19690']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19690"", ""source_version"": ""139"", ""title"": ""RHEA:19690 authority record"", ""url"": ""https://www.rhea-db.org/rhea/19690""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-014_36b5aec899aa	RHEA:19690	pathwaymech:produces	CHEBI:57642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19690		"[{""reference_id"": ""RHEA:19690"", ""source_assertion"": ""Rhea lists CHEBI:57642 on the products side of RHEA:19690 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19690']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19690"", ""source_version"": ""139"", ""title"": ""RHEA:19690 authority record"", ""url"": ""https://www.rhea-db.org/rhea/19690""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-015_4468079cc706	EC:5.1.3.32	pathwaymech:catalyzes	RHEA:25585	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25584		"[{""reference_id"": ""RHEA:25584"", ""source_assertion"": ""Rhea associates EC:5.1.3.32 with the reaction family containing RHEA:25585."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:25584"", ""source_version"": ""139"", ""title"": ""Rhea L-rhamnose mutarotase reaction"", ""url"": ""https://www.rhea-db.org/rhea/25584""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-016_2c4e234e8692	EC:5.3.1.14	pathwaymech:catalyzes	RHEA:23161	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23160		"[{""reference_id"": ""RHEA:23160"", ""source_assertion"": ""Rhea associates EC:5.3.1.14 with the reaction family containing RHEA:23161."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:23160"", ""source_version"": ""139"", ""title"": ""Rhea L-rhamnose isomerase reaction"", ""url"": ""https://www.rhea-db.org/rhea/23160""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-017_2261ba0b1233	EC:2.7.1.5	pathwaymech:catalyzes	RHEA:20118	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20117		"[{""reference_id"": ""RHEA:20117"", ""source_assertion"": ""Rhea associates EC:2.7.1.5 with the reaction family containing RHEA:20118."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:20117"", ""source_version"": ""139"", ""title"": ""Rhea generic rhamnulokinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/20117""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-018_c35b472b6d5b	EC:4.1.2.19	pathwaymech:catalyzes	RHEA:19690	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19689		"[{""reference_id"": ""RHEA:19689"", ""source_assertion"": ""Rhea associates EC:4.1.2.19 with the reaction family containing RHEA:19690."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:19689"", ""source_version"": ""139"", ""title"": ""Rhea generic rhamnulose-1-phosphate aldolase reaction"", ""url"": ""https://www.rhea-db.org/rhea/19689""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-019_9ad7663d748d	MetaCyc:RXN-15356	pathwaymech:precedes	RHEA:20118	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RHAMCAT-PWY		"[{""reference_id"": ""MetaCyc:RHAMCAT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places MetaCyc:RXN-15356 before RHEA:20118 in this pathway. The source ordering may bridge anomer-specific and broader substrate classes."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:RHAMCAT-PWY"", ""source_sha256"": ""86cba25f1b5cc26b86ecb496925e20e0ec205ce6b824f3b9bdbb95def16843b5"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-rhamnose degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:RHAMCAT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-020_5b4c19c4ea58	RHEA:20118	pathwaymech:precedes	RHEA:19690	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RHAMCAT-PWY		"[{""reference_id"": ""MetaCyc:RHAMCAT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:20118 before RHEA:19690 in this pathway. Shared intermediate: CHEBI:58313."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:RHAMCAT-PWY"", ""source_sha256"": ""86cba25f1b5cc26b86ecb496925e20e0ec205ce6b824f3b9bdbb95def16843b5"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-rhamnose degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:RHAMCAT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-021_e707b4e2284a	RHEA:23161	pathwaymech:precedes	MetaCyc:RXN-15356	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RHAMCAT-PWY		"[{""reference_id"": ""MetaCyc:RHAMCAT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:23161 before MetaCyc:RXN-15356 in this pathway. The source ordering may bridge anomer-specific and broader substrate classes."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:RHAMCAT-PWY"", ""source_sha256"": ""86cba25f1b5cc26b86ecb496925e20e0ec205ce6b824f3b9bdbb95def16843b5"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-rhamnose degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:RHAMCAT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_RHAMCAT-PWY_edge-022_9ada9dfbb5da	RHEA:25585	pathwaymech:precedes	RHEA:23161	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RHAMCAT-PWY		"[{""reference_id"": ""MetaCyc:RHAMCAT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:25585 before RHEA:23161 in this pathway. The source ordering may bridge anomer-specific and broader substrate classes."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:RHAMCAT-PWY"", ""source_sha256"": ""86cba25f1b5cc26b86ecb496925e20e0ec205ce6b824f3b9bdbb95def16843b5"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-rhamnose degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:RHAMCAT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-001_68e03e035bdb	CHEBI:57540	pathwaymech:consumes	RHEA:12642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12642		"[{""reference_id"": ""RHEA:12642"", ""source_assertion"": ""Rhea lists CHEBI:57540 on the substrates side of RHEA:12642 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12642']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12642"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic phosphoglycerate dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/12642""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-002_5c3271257d14	CHEBI:58272	pathwaymech:consumes	RHEA:12642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12642		"[{""reference_id"": ""RHEA:12642"", ""source_assertion"": ""Rhea lists CHEBI:58272 on the substrates side of RHEA:12642 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12642']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12642"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic phosphoglycerate dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/12642""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-003_005e74c973b6	RHEA:12642	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12642		"[{""reference_id"": ""RHEA:12642"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:12642 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12642']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12642"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic phosphoglycerate dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/12642""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-004_11db5b0677c4	RHEA:12642	pathwaymech:produces	CHEBI:18110	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12642		"[{""reference_id"": ""RHEA:12642"", ""source_assertion"": ""Rhea lists CHEBI:18110 on the products side of RHEA:12642 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12642']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12642"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic phosphoglycerate dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/12642""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-005_cb6f9a45fa13	RHEA:12642	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12642		"[{""reference_id"": ""RHEA:12642"", ""source_assertion"": ""Rhea lists CHEBI:57945 on the products side of RHEA:12642 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12642']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12642"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic phosphoglycerate dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/12642""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-006_2f0b9dabdf52	CHEBI:18110	pathwaymech:consumes	RHEA:14331	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14331		"[{""reference_id"": ""RHEA:14331"", ""source_assertion"": ""Rhea lists CHEBI:18110 on the substrates side of RHEA:14331 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14331']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14331"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic phosphoserine transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/14331""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-007_1ad64b844146	CHEBI:29985	pathwaymech:consumes	RHEA:14331	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14331		"[{""reference_id"": ""RHEA:14331"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the substrates side of RHEA:14331 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14331']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14331"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic phosphoserine transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/14331""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-008_81d1721bf43a	RHEA:14331	pathwaymech:produces	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14331		"[{""reference_id"": ""RHEA:14331"", ""source_assertion"": ""Rhea lists CHEBI:16810 on the products side of RHEA:14331 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14331']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14331"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic phosphoserine transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/14331""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-009_3da7667ea4a1	RHEA:14331	pathwaymech:produces	CHEBI:57524	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14331		"[{""reference_id"": ""RHEA:14331"", ""source_assertion"": ""Rhea lists CHEBI:57524 on the products side of RHEA:14331 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14331']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14331"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic phosphoserine transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/14331""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-010_701ca053ac73	CHEBI:15377	pathwaymech:consumes	RHEA:21209	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21209		"[{""reference_id"": ""RHEA:21209"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:21209 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21209']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21209"", ""source_version"": ""139"", ""title"": ""Rhea L-phosphoserine phosphatase direction"", ""url"": ""https://www.rhea-db.org/rhea/21209""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-011_62b262b3e788	CHEBI:57524	pathwaymech:consumes	RHEA:21209	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21209		"[{""reference_id"": ""RHEA:21209"", ""source_assertion"": ""Rhea lists CHEBI:57524 on the substrates side of RHEA:21209 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21209']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21209"", ""source_version"": ""139"", ""title"": ""Rhea L-phosphoserine phosphatase direction"", ""url"": ""https://www.rhea-db.org/rhea/21209""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-012_82ddad12e74d	RHEA:21209	pathwaymech:produces	CHEBI:33384	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21209		"[{""reference_id"": ""RHEA:21209"", ""source_assertion"": ""Rhea lists CHEBI:33384 on the products side of RHEA:21209 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21209']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21209"", ""source_version"": ""139"", ""title"": ""Rhea L-phosphoserine phosphatase direction"", ""url"": ""https://www.rhea-db.org/rhea/21209""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-013_9cd697bc6c46	RHEA:21209	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21209		"[{""reference_id"": ""RHEA:21209"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:21209 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21209']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21209"", ""source_version"": ""139"", ""title"": ""Rhea L-phosphoserine phosphatase direction"", ""url"": ""https://www.rhea-db.org/rhea/21209""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-014_11db996790a4	EC:1.1.1.95	pathwaymech:catalyzes	RHEA:12642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12641		"[{""reference_id"": ""RHEA:12641"", ""source_assertion"": ""Rhea associates EC:1.1.1.95 with the reaction family containing RHEA:12642."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:12641"", ""source_version"": ""139"", ""title"": ""RHEA:12641 authority record"", ""url"": ""https://www.rhea-db.org/rhea/12641""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-015_792943936fd8	EC:2.6.1.52	pathwaymech:catalyzes	RHEA:14331	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14329		"[{""reference_id"": ""RHEA:14329"", ""source_assertion"": ""Rhea associates EC:2.6.1.52 with the reaction family containing RHEA:14331."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:14329"", ""source_version"": ""139"", ""title"": ""RHEA:14329 authority record"", ""url"": ""https://www.rhea-db.org/rhea/14329""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-016_18144412fc61	EC:3.1.3.3	pathwaymech:catalyzes	RHEA:21209	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21208		"[{""reference_id"": ""RHEA:21208"", ""source_assertion"": ""Rhea associates EC:3.1.3.3 with the reaction family containing RHEA:21209."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:21208"", ""source_version"": ""139"", ""title"": ""RHEA:21208 authority record"", ""url"": ""https://www.rhea-db.org/rhea/21208""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-017_e619ce44e9a5	RHEA:12642	pathwaymech:precedes	RHEA:14331	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:SERSYN-PWY		"[{""reference_id"": ""MetaCyc:SERSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:12642 before RHEA:14331 in this pathway. Shared intermediate: CHEBI:18110."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:SERSYN-PWY"", ""source_sha256"": ""e49def9474b0c802e48e70dee533819be06d16d23b856e8da3210df19d55a74a"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-serine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:SERSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-018_323476523007	RHEA:14331	pathwaymech:precedes	RHEA:21209	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:SERSYN-PWY		"[{""reference_id"": ""MetaCyc:SERSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:14331 before RHEA:21209 in this pathway. Shared intermediate: CHEBI:57524."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:SERSYN-PWY"", ""source_sha256"": ""e49def9474b0c802e48e70dee533819be06d16d23b856e8da3210df19d55a74a"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-serine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:SERSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-019_81738d85b0b1	UniProtKB:P0A9T0	pathwaymech:enables	RHEA:12642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9T0		"[{""reference_id"": ""UniProtKB:P0A9T0"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A9T0 with catalytic activity for the reaction family of RHEA:12642. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A9T0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9T0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9T0.json""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-020_4534fc636783	CHEBI:33384	pathwaymech:inhibits	UniProtKB:P0A9T0	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9T0		"[{""reference_id"": ""UniProtKB:P0A9T0"", ""source_assertion"": ""UniProt activity-regulation annotation: Displays feedback inhibition by L-serine. Inhibited by glycine"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P0A9T0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9T0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9T0.json""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-021_8afabd322519	UniProtKB:P0AGB0	pathwaymech:enables	RHEA:21209	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AGB0		"[{""reference_id"": ""UniProtKB:P0AGB0"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AGB0 with catalytic activity for the reaction family of RHEA:21209. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AGB0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AGB0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AGB0.json""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-022_55c209be7de4	UniProtKB:P0AGB0	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AGB0		"[{""reference_id"": ""UniProtKB:P0AGB0"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P0AGB0 (evidence: ECO:0000269). Binds 1 Mg(2+) ion per subunit. Can also use other divalent metal cations as Mn(2+), Co(2+) and Zn(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AGB0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AGB0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AGB0.json""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-023_7ee6d1e80405	UniProtKB:P0AGB0	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AGB0		"[{""reference_id"": ""UniProtKB:P0AGB0"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P0AGB0 (evidence: ECO:0000269). Binds 1 Mg(2+) ion per subunit. Can also use other divalent metal cations as Mn(2+), Co(2+) and Zn(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AGB0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AGB0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AGB0.json""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-024_2c0c3a917cef	UniProtKB:P0AGB0	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AGB0		"[{""reference_id"": ""UniProtKB:P0AGB0"", ""source_assertion"": ""UniProt lists CHEBI:48828 as a cofactor of UniProtKB:P0AGB0 (evidence: ECO:0000269). Binds 1 Mg(2+) ion per subunit. Can also use other divalent metal cations as Mn(2+), Co(2+) and Zn(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AGB0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AGB0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AGB0.json""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-025_b2a35a2df346	UniProtKB:P0AGB0	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AGB0		"[{""reference_id"": ""UniProtKB:P0AGB0"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P0AGB0 (evidence: ECO:0000269). Binds 1 Mg(2+) ion per subunit. Can also use other divalent metal cations as Mn(2+), Co(2+) and Zn(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AGB0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AGB0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AGB0.json""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-026_17513d91e4f8	UniProtKB:P23721	pathwaymech:enables	RHEA:14331	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23721		"[{""reference_id"": ""UniProtKB:P23721"", ""source_assertion"": ""UniProt annotates UniProtKB:P23721 with catalytic activity for the reaction family of RHEA:14331. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P23721"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P23721 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23721.json""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-027_081015ccc278	UniProtKB:P23721	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23721		"[{""reference_id"": ""UniProtKB:P23721"", ""source_assertion"": ""UniProt locates UniProtKB:P23721 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P23721"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P23721 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23721.json""}]"	""
pathwaymech:MetaCyc_SERSYN-PWY_edge-028_ba9e601e73ea	UniProtKB:P23721	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23721		"[{""reference_id"": ""UniProtKB:P23721"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P23721 (evidence: ECO:0000269). Binds 1 pyridoxal phosphate per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P23721"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P23721 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23721.json""}]"	""
pathwaymech:MetaCyc_HOMOSER-THRESYN-PWY_edge-001_b15b3f5ac03d	CHEBI:30616	pathwaymech:consumes	RHEA:13986	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13986		"[{""reference_id"": ""RHEA:13986"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:13986 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13986']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13986"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic homoserine kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/13986""}]"	""
pathwaymech:MetaCyc_HOMOSER-THRESYN-PWY_edge-002_95ec9dbb653f	CHEBI:57476	pathwaymech:consumes	RHEA:13986	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13986		"[{""reference_id"": ""RHEA:13986"", ""source_assertion"": ""Rhea lists CHEBI:57476 on the substrates side of RHEA:13986 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13986']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13986"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic homoserine kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/13986""}]"	""
pathwaymech:MetaCyc_HOMOSER-THRESYN-PWY_edge-003_f712506a69a5	RHEA:13986	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13986		"[{""reference_id"": ""RHEA:13986"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:13986 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13986']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13986"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic homoserine kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/13986""}]"	""
pathwaymech:MetaCyc_HOMOSER-THRESYN-PWY_edge-004_3a09e0c865e6	RHEA:13986	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13986		"[{""reference_id"": ""RHEA:13986"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:13986 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13986']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13986"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic homoserine kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/13986""}]"	""
pathwaymech:MetaCyc_HOMOSER-THRESYN-PWY_edge-005_9bab48402d8c	RHEA:13986	pathwaymech:produces	CHEBI:57590	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13986		"[{""reference_id"": ""RHEA:13986"", ""source_assertion"": ""Rhea lists CHEBI:57590 on the products side of RHEA:13986 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13986']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13986"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic homoserine kinase direction"", ""url"": ""https://www.rhea-db.org/rhea/13986""}]"	""
pathwaymech:MetaCyc_HOMOSER-THRESYN-PWY_edge-006_2b71fb666843	CHEBI:15377	pathwaymech:consumes	RHEA:10841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10841		"[{""reference_id"": ""RHEA:10841"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:10841 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10841']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10841"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right L-threonine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/10841""}]"	""
pathwaymech:MetaCyc_HOMOSER-THRESYN-PWY_edge-007_9c26bc7ce049	CHEBI:57590	pathwaymech:consumes	RHEA:10841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10841		"[{""reference_id"": ""RHEA:10841"", ""source_assertion"": ""Rhea lists CHEBI:57590 on the substrates side of RHEA:10841 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10841']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10841"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right L-threonine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/10841""}]"	""
pathwaymech:MetaCyc_HOMOSER-THRESYN-PWY_edge-008_8aa2bd829c26	RHEA:10841	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10841		"[{""reference_id"": ""RHEA:10841"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:10841 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10841']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10841"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right L-threonine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/10841""}]"	""
pathwaymech:MetaCyc_HOMOSER-THRESYN-PWY_edge-009_9b0d36111588	RHEA:10841	pathwaymech:produces	CHEBI:57926	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10841		"[{""reference_id"": ""RHEA:10841"", ""source_assertion"": ""Rhea lists CHEBI:57926 on the products side of RHEA:10841 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10841']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10841"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right L-threonine synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/10841""}]"	""
pathwaymech:MetaCyc_HOMOSER-THRESYN-PWY_edge-010_e69af1c23f04	EC:2.7.1.39	pathwaymech:catalyzes	RHEA:13986	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:8973190|RHEA:13985		"[{""reference_id"": ""RHEA:13985"", ""source_assertion"": ""Rhea associates EC:2.7.1.39 with the reaction family containing RHEA:13986."", ""source_locator"": ""rh:ec""}, {""quote"": ""Homoserine kinase, an enzyme in the aspartate pathway of amino acid biosynthesis in Escherichia coli, catalyzes the conversion of L-homoserine to L-homoserine phosphate."", ""reference_id"": ""PMID:8973190"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Huo and Viola, Biochemistry, 1996"", ""id"": ""PMID:8973190"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/8973190/""}, {""id"": ""RHEA:13985"", ""source_version"": ""139"", ""title"": ""RHEA:13985 authority record"", ""url"": ""https://www.rhea-db.org/rhea/13985""}]"	""
pathwaymech:MetaCyc_HOMOSER-THRESYN-PWY_edge-011_bbcf915a93b0	EC:4.2.3.1	pathwaymech:catalyzes	RHEA:10841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10840		"[{""reference_id"": ""RHEA:10840"", ""source_assertion"": ""Rhea associates EC:4.2.3.1 with the reaction family containing RHEA:10841."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:10840"", ""source_version"": ""139"", ""title"": ""Rhea L-threonine synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/10840""}]"	""
pathwaymech:MetaCyc_HOMOSER-THRESYN-PWY_edge-012_d8d256c8f2ed	RHEA:13986	pathwaymech:precedes	RHEA:10841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HOMOSER-THRESYN-PWY		"[{""reference_id"": ""MetaCyc:HOMOSER-THRESYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:13986 before RHEA:10841 in this pathway. Shared intermediate: CHEBI:57590."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:HOMOSER-THRESYN-PWY"", ""source_sha256"": ""47d990ae314434c39015611be76b50fc339ac19f6f8d221ad5598d97277c64f0"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-threonine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:HOMOSER-THRESYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_HOMOSER-THRESYN-PWY_edge-013_a89b6d27c73d	UniProtKB:P00547	pathwaymech:enables	RHEA:13986	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00547		"[{""reference_id"": ""UniProtKB:P00547"", ""source_assertion"": ""UniProt annotates UniProtKB:P00547 with catalytic activity for the reaction family of RHEA:13986. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00547"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00547 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00547.json""}]"	""
pathwaymech:MetaCyc_HOMOSER-THRESYN-PWY_edge-014_79d51eeb45bd	UniProtKB:P00547	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00547		"[{""reference_id"": ""UniProtKB:P00547"", ""source_assertion"": ""UniProt locates UniProtKB:P00547 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P00547"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00547 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00547.json""}]"	""
pathwaymech:MetaCyc_HOMOSER-THRESYN-PWY_edge-015_b930bd9a7327	UniProtKB:P00934	pathwaymech:enables	RHEA:10841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00934		"[{""reference_id"": ""UniProtKB:P00934"", ""source_assertion"": ""UniProt annotates UniProtKB:P00934 with catalytic activity for the reaction family of RHEA:10841. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00934"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00934 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00934.json""}]"	""
pathwaymech:MetaCyc_HOMOSER-THRESYN-PWY_edge-016_8177a2917631	UniProtKB:P00934	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00934		"[{""reference_id"": ""UniProtKB:P00934"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P00934 (evidence: ECO:0000269). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P00934"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00934 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00934.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-001_22c6c334b4cd	CHEBI:57926	pathwaymech:consumes	RHEA:13162	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13162	The directed native Rhea reaction has CHEBI:57926 on its substrates side with coefficient 1.	"[{""reference_id"": ""RHEA:13162"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:57926 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/13162/rh:substrates -> http://rdf.rhea-db.org/13161_L -> http://rdf.rhea-db.org/Participant_13161_compound_3255 -> http://rdf.rhea-db.org/Compound_3255/rh:chebi""}]"	"[{""id"": ""RHEA:13162"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""L-threonine + NAD(+) => (2S)-2-amino-3-oxobutanoate + NADH + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-002_896f66236f9c	CHEBI:57540	pathwaymech:consumes	RHEA:13162	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13162	The directed native Rhea reaction has CHEBI:57540 on its substrates side with coefficient 1.	"[{""reference_id"": ""RHEA:13162"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:57540 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/13162/rh:substrates -> http://rdf.rhea-db.org/13161_L -> http://rdf.rhea-db.org/Participant_13161_compound_3484 -> http://rdf.rhea-db.org/Compound_3484/rh:chebi""}]"	"[{""id"": ""RHEA:13162"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""L-threonine + NAD(+) => (2S)-2-amino-3-oxobutanoate + NADH + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-003_520be4e378b7	RHEA:13162	pathwaymech:produces	CHEBI:78948	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13162	The directed native Rhea reaction has CHEBI:78948 on its products side with coefficient 1.	"[{""reference_id"": ""RHEA:13162"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:78948 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/13162/rh:products -> http://rdf.rhea-db.org/13161_R -> http://rdf.rhea-db.org/Participant_13161_compound_10587 -> http://rdf.rhea-db.org/Compound_10587/rh:chebi""}]"	"[{""id"": ""RHEA:13162"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""L-threonine + NAD(+) => (2S)-2-amino-3-oxobutanoate + NADH + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-004_6f8908cf73b3	RHEA:13162	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13162	The directed native Rhea reaction has CHEBI:57945 on its products side with coefficient 1.	"[{""reference_id"": ""RHEA:13162"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:57945 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/13162/rh:products -> http://rdf.rhea-db.org/13161_R -> http://rdf.rhea-db.org/Participant_13161_compound_1650 -> http://rdf.rhea-db.org/Compound_1650/rh:chebi""}]"	"[{""id"": ""RHEA:13162"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""L-threonine + NAD(+) => (2S)-2-amino-3-oxobutanoate + NADH + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-005_a3eae55599dc	RHEA:13162	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13162	The directed native Rhea reaction has CHEBI:15378 on its products side with coefficient 1.	"[{""reference_id"": ""RHEA:13162"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:15378 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/13162/rh:products -> http://rdf.rhea-db.org/13161_R -> http://rdf.rhea-db.org/Participant_13161_compound_3249 -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:13162"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""L-threonine + NAD(+) => (2S)-2-amino-3-oxobutanoate + NADH + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-006_5a22e7b64936	CHEBI:78948	pathwaymech:consumes	RHEA:25654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25654	The directed native Rhea reaction has CHEBI:78948 on its substrates side with coefficient 1.	"[{""reference_id"": ""RHEA:25654"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:78948 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25654/rh:substrates -> http://rdf.rhea-db.org/25653_L -> http://rdf.rhea-db.org/Participant_25653_compound_10587 -> http://rdf.rhea-db.org/Compound_10587/rh:chebi""}]"	"[{""id"": ""RHEA:25654"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""(2S)-2-amino-3-oxobutanoate + H(+) => aminoacetone + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-007_e3a07f1aaf94	CHEBI:15378	pathwaymech:consumes	RHEA:25654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25654	The directed native Rhea reaction has CHEBI:15378 on its substrates side with coefficient 1.	"[{""reference_id"": ""RHEA:25654"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:15378 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25654/rh:substrates -> http://rdf.rhea-db.org/25653_L -> http://rdf.rhea-db.org/Participant_25653_compound_3249 -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:25654"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""(2S)-2-amino-3-oxobutanoate + H(+) => aminoacetone + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-008_3c7bd6305a8c	RHEA:25654	pathwaymech:produces	CHEBI:58320	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25654	The directed native Rhea reaction has CHEBI:58320 on its products side with coefficient 1.	"[{""reference_id"": ""RHEA:25654"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:58320 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25654/rh:products -> http://rdf.rhea-db.org/25653_R -> http://rdf.rhea-db.org/Participant_25653_compound_1881 -> http://rdf.rhea-db.org/Compound_1881/rh:chebi""}]"	"[{""id"": ""RHEA:25654"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""(2S)-2-amino-3-oxobutanoate + H(+) => aminoacetone + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-009_a9c9e14a5258	RHEA:25654	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25654	The directed native Rhea reaction has CHEBI:16526 on its products side with coefficient 1.	"[{""reference_id"": ""RHEA:25654"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:16526 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25654/rh:products -> http://rdf.rhea-db.org/25653_R -> http://rdf.rhea-db.org/Participant_25653_compound_4391 -> http://rdf.rhea-db.org/Compound_4391/rh:chebi""}]"	"[{""id"": ""RHEA:25654"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""(2S)-2-amino-3-oxobutanoate + H(+) => aminoacetone + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-010_4f81dc7463e5	CHEBI:58320	pathwaymech:consumes	RHEA:28187	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28187	The directed native Rhea reaction has CHEBI:58320 on its substrates side with coefficient 1.	"[{""reference_id"": ""RHEA:28187"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:58320 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/28187/rh:substrates -> http://rdf.rhea-db.org/28186_L -> http://rdf.rhea-db.org/Participant_28186_compound_1881 -> http://rdf.rhea-db.org/Compound_1881/rh:chebi""}]"	"[{""id"": ""RHEA:28187"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""aminoacetone + O2 + H2O => methylglyoxal + H2O2 + NH4(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-011_4402a20b5f7e	CHEBI:15379	pathwaymech:consumes	RHEA:28187	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28187	The directed native Rhea reaction has CHEBI:15379 on its substrates side with coefficient 1.	"[{""reference_id"": ""RHEA:28187"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:15379 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/28187/rh:substrates -> http://rdf.rhea-db.org/28186_L -> http://rdf.rhea-db.org/Participant_28186_compound_1198 -> http://rdf.rhea-db.org/Compound_1198/rh:chebi""}]"	"[{""id"": ""RHEA:28187"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""aminoacetone + O2 + H2O => methylglyoxal + H2O2 + NH4(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-012_733965eb6548	CHEBI:15377	pathwaymech:consumes	RHEA:28187	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28187	The directed native Rhea reaction has CHEBI:15377 on its substrates side with coefficient 1.	"[{""reference_id"": ""RHEA:28187"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:15377 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/28187/rh:substrates -> http://rdf.rhea-db.org/28186_L -> http://rdf.rhea-db.org/Participant_28186_compound_1283 -> http://rdf.rhea-db.org/Compound_1283/rh:chebi""}]"	"[{""id"": ""RHEA:28187"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""aminoacetone + O2 + H2O => methylglyoxal + H2O2 + NH4(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-013_38e0e62d84a0	RHEA:28187	pathwaymech:produces	CHEBI:17158	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28187	The directed native Rhea reaction has CHEBI:17158 on its products side with coefficient 1.	"[{""reference_id"": ""RHEA:28187"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:17158 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/28187/rh:products -> http://rdf.rhea-db.org/28186_R -> http://rdf.rhea-db.org/Participant_28186_compound_4547 -> http://rdf.rhea-db.org/Compound_4547/rh:chebi""}]"	"[{""id"": ""RHEA:28187"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""aminoacetone + O2 + H2O => methylglyoxal + H2O2 + NH4(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-014_ab167ac31ca8	RHEA:28187	pathwaymech:produces	CHEBI:16240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28187	The directed native Rhea reaction has CHEBI:16240 on its products side with coefficient 1.	"[{""reference_id"": ""RHEA:28187"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:16240 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/28187/rh:products -> http://rdf.rhea-db.org/28186_R -> http://rdf.rhea-db.org/Participant_28186_compound_3075 -> http://rdf.rhea-db.org/Compound_3075/rh:chebi""}]"	"[{""id"": ""RHEA:28187"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""aminoacetone + O2 + H2O => methylglyoxal + H2O2 + NH4(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-015_50c889fffd5f	RHEA:28187	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28187	The directed native Rhea reaction has CHEBI:28938 on its products side with coefficient 1.	"[{""reference_id"": ""RHEA:28187"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:28938 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/28187/rh:products -> http://rdf.rhea-db.org/28186_R -> http://rdf.rhea-db.org/Participant_28186_compound_1012 -> http://rdf.rhea-db.org/Compound_1012/rh:chebi""}]"	"[{""id"": ""RHEA:28187"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""aminoacetone + O2 + H2O => methylglyoxal + H2O2 + NH4(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-016_5b1116b13a3c	CHEBI:57926	pathwaymech:consumes	RHEA:70001	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:70001	The directed native Rhea reaction has CHEBI:57926 on its substrates side with coefficient 1. Transport compartment tags are retained in the formal equation; shared ChEBI identity does not collapse the two spatial sides.	"[{""reference_id"": ""RHEA:70001"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:57926 on its substrates side with coefficient 1. Transport compartment tags are retained in the formal equation; shared ChEBI identity does not collapse the two spatial sides."", ""source_locator"": ""http://rdf.rhea-db.org/70001/rh:substrates -> http://rdf.rhea-db.org/69999_R -> http://rdf.rhea-db.org/Participant_69999_compound_3255_out -> http://rdf.rhea-db.org/Compound_3255/rh:chebi""}]"	"[{""id"": ""RHEA:70001"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""L-threonine(out) + Na(+)(out) => L-threonine(in) + Na(+)(in)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-017_7e9523893bec	CHEBI:29101	pathwaymech:consumes	RHEA:70001	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:70001	The directed native Rhea reaction has CHEBI:29101 on its substrates side with coefficient 1. Transport compartment tags are retained in the formal equation; shared ChEBI identity does not collapse the two spatial sides.	"[{""reference_id"": ""RHEA:70001"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:29101 on its substrates side with coefficient 1. Transport compartment tags are retained in the formal equation; shared ChEBI identity does not collapse the two spatial sides."", ""source_locator"": ""http://rdf.rhea-db.org/70001/rh:substrates -> http://rdf.rhea-db.org/69999_R -> http://rdf.rhea-db.org/Participant_69999_compound_2426_out -> http://rdf.rhea-db.org/Compound_2426/rh:chebi""}]"	"[{""id"": ""RHEA:70001"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""L-threonine(out) + Na(+)(out) => L-threonine(in) + Na(+)(in)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-018_ee62d4dc130e	RHEA:70001	pathwaymech:produces	CHEBI:57926	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:70001	The directed native Rhea reaction has CHEBI:57926 on its products side with coefficient 1. Transport compartment tags are retained in the formal equation; shared ChEBI identity does not collapse the two spatial sides.	"[{""reference_id"": ""RHEA:70001"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:57926 on its products side with coefficient 1. Transport compartment tags are retained in the formal equation; shared ChEBI identity does not collapse the two spatial sides."", ""source_locator"": ""http://rdf.rhea-db.org/70001/rh:products -> http://rdf.rhea-db.org/69999_L -> http://rdf.rhea-db.org/Participant_69999_compound_3255_in -> http://rdf.rhea-db.org/Compound_3255/rh:chebi""}]"	"[{""id"": ""RHEA:70001"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""L-threonine(out) + Na(+)(out) => L-threonine(in) + Na(+)(in)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-019_f344185a6448	RHEA:70001	pathwaymech:produces	CHEBI:29101	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:70001	The directed native Rhea reaction has CHEBI:29101 on its products side with coefficient 1. Transport compartment tags are retained in the formal equation; shared ChEBI identity does not collapse the two spatial sides.	"[{""reference_id"": ""RHEA:70001"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:29101 on its products side with coefficient 1. Transport compartment tags are retained in the formal equation; shared ChEBI identity does not collapse the two spatial sides."", ""source_locator"": ""http://rdf.rhea-db.org/70001/rh:products -> http://rdf.rhea-db.org/69999_L -> http://rdf.rhea-db.org/Participant_69999_compound_2426_in -> http://rdf.rhea-db.org/Compound_2426/rh:chebi""}]"	"[{""id"": ""RHEA:70001"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""L-threonine(out) + Na(+)(out) => L-threonine(in) + Na(+)(in)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-020_465dd2069418	CHEBI:57926	pathwaymech:consumes	RHEA:28885	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28885	The directed native Rhea reaction has CHEBI:57926 on its substrates side with coefficient 1. Transport compartment tags are retained in the formal equation; shared ChEBI identity does not collapse the two spatial sides.	"[{""reference_id"": ""RHEA:28885"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:57926 on its substrates side with coefficient 1. Transport compartment tags are retained in the formal equation; shared ChEBI identity does not collapse the two spatial sides."", ""source_locator"": ""http://rdf.rhea-db.org/28885/rh:substrates -> http://rdf.rhea-db.org/28883_R -> http://rdf.rhea-db.org/Participant_28883_compound_3255_out -> http://rdf.rhea-db.org/Compound_3255/rh:chebi""}]"	"[{""id"": ""RHEA:28885"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""L-threonine(out) + H(+)(out) => L-threonine(in) + H(+)(in)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-021_2f9da237523f	CHEBI:15378	pathwaymech:consumes	RHEA:28885	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28885	The directed native Rhea reaction has CHEBI:15378 on its substrates side with coefficient 1. Transport compartment tags are retained in the formal equation; shared ChEBI identity does not collapse the two spatial sides.	"[{""reference_id"": ""RHEA:28885"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:15378 on its substrates side with coefficient 1. Transport compartment tags are retained in the formal equation; shared ChEBI identity does not collapse the two spatial sides."", ""source_locator"": ""http://rdf.rhea-db.org/28885/rh:substrates -> http://rdf.rhea-db.org/28883_R -> http://rdf.rhea-db.org/Participant_28883_compound_3249_out -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:28885"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""L-threonine(out) + H(+)(out) => L-threonine(in) + H(+)(in)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-022_6a0a084be0fd	RHEA:28885	pathwaymech:produces	CHEBI:57926	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28885	The directed native Rhea reaction has CHEBI:57926 on its products side with coefficient 1. Transport compartment tags are retained in the formal equation; shared ChEBI identity does not collapse the two spatial sides.	"[{""reference_id"": ""RHEA:28885"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:57926 on its products side with coefficient 1. Transport compartment tags are retained in the formal equation; shared ChEBI identity does not collapse the two spatial sides."", ""source_locator"": ""http://rdf.rhea-db.org/28885/rh:products -> http://rdf.rhea-db.org/28883_L -> http://rdf.rhea-db.org/Participant_28883_compound_3255_in -> http://rdf.rhea-db.org/Compound_3255/rh:chebi""}]"	"[{""id"": ""RHEA:28885"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""L-threonine(out) + H(+)(out) => L-threonine(in) + H(+)(in)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-023_cd9f87229dc8	RHEA:28885	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28885	The directed native Rhea reaction has CHEBI:15378 on its products side with coefficient 1. Transport compartment tags are retained in the formal equation; shared ChEBI identity does not collapse the two spatial sides.	"[{""reference_id"": ""RHEA:28885"", ""source_assertion"": ""The directed native Rhea reaction has CHEBI:15378 on its products side with coefficient 1. Transport compartment tags are retained in the formal equation; shared ChEBI identity does not collapse the two spatial sides."", ""source_locator"": ""http://rdf.rhea-db.org/28885/rh:products -> http://rdf.rhea-db.org/28883_L -> http://rdf.rhea-db.org/Participant_28883_compound_3249_in -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:28885"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142 (2026-09-02); whole retained RDF original; freshly extracted exact master/directional relation and complete chemical sides"", ""title"": ""L-threonine(out) + H(+)(out) => L-threonine(in) + H(+)(in)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-024_1e8936008f2b	RHEA:13162	BFO:0000050	MetaCyc:THRDLCTCAT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:THRDLCTCAT-PWY|MetaCyc:THREODEHYD-RXN	The complete native three-event pathway includes THREODEHYD-RXN; its mapped directional Rhea event is RHEA:13162. Spontaneous decarboxylation is retained as an elementary event.	"[{""reference_id"": ""MetaCyc:THRDLCTCAT-PWY"", ""source_assertion"": ""The complete native three-event pathway includes THREODEHYD-RXN. Spontaneous decarboxylation remains an elementary event."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list/Reaction[@frameid=\""THREODEHYD-RXN\""]""}, {""reference_id"": ""MetaCyc:THREODEHYD-RXN"", ""source_assertion"": ""The native reaction has a RHEA unification dblink to directional reaction 13162."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\"" and dblink-relationship=\""unification\""]/dblink-oid""}]"	"[{""id"": ""MetaCyc:THRDLCTCAT-PWY"", ""source_sha256"": ""0e001f6deb9a96918006085d71f05393519cbf1c522fbe5523c5b3c285e0505e"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""MetaCyc THRDLCTCAT-PWY: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:THRDLCTCAT-PWY""}, {""id"": ""MetaCyc:THREODEHYD-RXN"", ""source_sha256"": ""ab76fe4eee0cac00deb219b1591bfe076dfe6fe7d6d16df1451da06e22e76726"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""MetaCyc THREODEHYD-RXN: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:THREODEHYD-RXN""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-025_4b14671d7f83	RHEA:25654	BFO:0000050	MetaCyc:THRDLCTCAT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:THRDLCTCAT-PWY|MetaCyc:THREOSPON-RXN	The complete native three-event pathway includes THREOSPON-RXN; its mapped directional Rhea event is RHEA:25654. Spontaneous decarboxylation is retained as an elementary event.	"[{""reference_id"": ""MetaCyc:THRDLCTCAT-PWY"", ""source_assertion"": ""The complete native three-event pathway includes THREOSPON-RXN. Spontaneous decarboxylation remains an elementary event."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list/Reaction[@frameid=\""THREOSPON-RXN\""]""}, {""reference_id"": ""MetaCyc:THREOSPON-RXN"", ""source_assertion"": ""The native reaction has a RHEA unification dblink to directional reaction 25654."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\"" and dblink-relationship=\""unification\""]/dblink-oid""}]"	"[{""id"": ""MetaCyc:THRDLCTCAT-PWY"", ""source_sha256"": ""0e001f6deb9a96918006085d71f05393519cbf1c522fbe5523c5b3c285e0505e"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""MetaCyc THRDLCTCAT-PWY: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:THRDLCTCAT-PWY""}, {""id"": ""MetaCyc:THREOSPON-RXN"", ""source_sha256"": ""7eba46e63f96c8ae1911b1d30085d7ba31f81bf003dea0c9f0d434b1d05425d3"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""MetaCyc THREOSPON-RXN: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:THREOSPON-RXN""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-026_4c59d505890a	RHEA:28187	BFO:0000050	MetaCyc:THRDLCTCAT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:AMACETOXID-RXN|MetaCyc:THRDLCTCAT-PWY	The complete native three-event pathway includes AMACETOXID-RXN; its mapped directional Rhea event is RHEA:28187. Spontaneous decarboxylation is retained as an elementary event.	"[{""reference_id"": ""MetaCyc:THRDLCTCAT-PWY"", ""source_assertion"": ""The complete native three-event pathway includes AMACETOXID-RXN. Spontaneous decarboxylation remains an elementary event."", ""source_locator"": ""/ptools-xml/Pathway/reaction-list/Reaction[@frameid=\""AMACETOXID-RXN\""]""}, {""reference_id"": ""MetaCyc:AMACETOXID-RXN"", ""source_assertion"": ""The native reaction has a RHEA unification dblink to directional reaction 28187."", ""source_locator"": ""/ptools-xml/Reaction/dblink[dblink-db=\""RHEA\"" and dblink-relationship=\""unification\""]/dblink-oid""}]"	"[{""id"": ""MetaCyc:AMACETOXID-RXN"", ""source_sha256"": ""9379f3586ea1076283f2d1b736e5c3585c621cb8535027c79201171ea45419bc"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""MetaCyc AMACETOXID-RXN: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:AMACETOXID-RXN""}, {""id"": ""MetaCyc:THRDLCTCAT-PWY"", ""source_sha256"": ""0e001f6deb9a96918006085d71f05393519cbf1c522fbe5523c5b3c285e0505e"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""MetaCyc THRDLCTCAT-PWY: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:THRDLCTCAT-PWY""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-027_4cc1a5fa0f41	RHEA:13162	pathwaymech:precedes	RHEA:25654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:THRDLCTCAT-PWY	The native route oxidizes threonine before spontaneous decarboxylation of its unstable 2-amino-3-oxo intermediate.	"[{""reference_id"": ""MetaCyc:THRDLCTCAT-PWY"", ""source_assertion"": ""The native route oxidizes threonine before spontaneous decarboxylation of its unstable 2-amino-3-oxo intermediate."", ""source_locator"": ""reaction-layout, reaction-ordering and comment""}]"	"[{""id"": ""MetaCyc:THRDLCTCAT-PWY"", ""source_sha256"": ""0e001f6deb9a96918006085d71f05393519cbf1c522fbe5523c5b3c285e0505e"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""MetaCyc THRDLCTCAT-PWY: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:THRDLCTCAT-PWY""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-028_4f075759386d	RHEA:25654	pathwaymech:precedes	RHEA:28187	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:THRDLCTCAT-PWY	Aminoacetone from spontaneous decarboxylation is the input to terminal oxidation; the E. coli catalyst assignment remains hypothetical.	"[{""reference_id"": ""MetaCyc:THRDLCTCAT-PWY"", ""source_assertion"": ""Aminoacetone from spontaneous decarboxylation is the input to terminal oxidation; the E. coli catalyst assignment remains hypothetical."", ""source_locator"": ""reaction-layout and comment""}]"	"[{""id"": ""MetaCyc:THRDLCTCAT-PWY"", ""source_sha256"": ""0e001f6deb9a96918006085d71f05393519cbf1c522fbe5523c5b3c285e0505e"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""MetaCyc THRDLCTCAT-PWY: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:THRDLCTCAT-PWY""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-029_08c6c9411bb8	MetaCyc:THRDLCTCAT-PWY	BFO:0000050	MetaCyc:THREOCAT-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:THRDLCTCAT-PWY	The native record places the complete degradation-III route in the threonine-metabolism superpathway; the parent is an opaque hierarchy context.	"[{""reference_id"": ""MetaCyc:THRDLCTCAT-PWY"", ""source_assertion"": ""The native record places the complete degradation-III route in the threonine-metabolism superpathway; the parent is an opaque hierarchy context."", ""source_locator"": ""Pathway/super-pathways""}]"	"[{""id"": ""MetaCyc:THRDLCTCAT-PWY"", ""source_sha256"": ""0e001f6deb9a96918006085d71f05393519cbf1c522fbe5523c5b3c285e0505e"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""MetaCyc THRDLCTCAT-PWY: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:THRDLCTCAT-PWY""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-030_62bfd11f8d76	MetaCyc:PWY-5386	RO:0002233	CHEBI:17158	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:THRDLCTCAT-PWY	The native pathway-link connects the methylglyoxal product to methylglyoxal degradation I; no downstream chemistry is imported here.	"[{""reference_id"": ""MetaCyc:THRDLCTCAT-PWY"", ""source_assertion"": ""The native pathway-link connects the methylglyoxal product to methylglyoxal degradation I; no downstream chemistry is imported here."", ""source_locator"": ""/ptools-xml/Pathway/pathway-link[Compound/@frameid=\""METHYL-GLYOXAL\""]/link-target/Pathway[@frameid=\""PWY-5386\""]""}]"	"[{""id"": ""MetaCyc:THRDLCTCAT-PWY"", ""source_sha256"": ""0e001f6deb9a96918006085d71f05393519cbf1c522fbe5523c5b3c285e0505e"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""MetaCyc THRDLCTCAT-PWY: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:THRDLCTCAT-PWY""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-031_884e681bd9c1	PathBank:SMP0000837	RO:0002234	CHEBI:57926	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002118|PathBank:SMP0002118/PWML	The current BioPAX includes a named threonine-biosynthesis SubPathway and its threonine-supply interface. This is a non-elementary upstream connection, not an additional degradation reaction. Neutral PathBank threonine is represented here by Rhea physiological L-threonine with the protonation distinction retained.	"[{""reference_id"": ""PathBank:SMP0002118"", ""source_assertion"": ""The current BioPAX includes a named threonine-biosynthesis SubPathway and its threonine-supply interface. This is a non-elementary upstream connection, not an additional degradation reaction. Neutral PathBank threonine is represented here by Rhea physiological L-threonine with the protonation distinction retained."", ""source_locator"": ""Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0000837\""]/displayName, xref and pathwayComponent; SubPathwayInteractions/528933 participant Compound/PW_C000109""}, {""reference_id"": ""PathBank:SMP0002118/PWML"", ""source_assertion"": ""The intact native SubPathway fragment identifies ID528933/reference581 with Compound109 as output; its visualization places that compound on the Right. The separate BioPAX supplies the SMP0000837 identifier and biological title."", ""source_locator"": ""Original PWML lines 24–39: sub-pathways/sub-pathway[id=528933]/reference-pathway-id=581; sub-pathway-outputs/sub-pathway-output/element-id=109 and element-type=Compound. Lines 9196–9216: sub-pathway-visualizations/sub-pathway-visualization[sub-pathway-id=528933]/sub_pathway_compound_visualizations/sub-pathway-compound-visualization/side=Right""}]"	"[{""id"": ""PathBank:SMP0002118"", ""source_sha256"": ""e022c5945592f63f5b7fc7b099705f765b5d01131e00ac45332331aae9c17cdf"", ""source_version"": ""Current issuing BioPAX retrieved 2026-10-11; root, three chemical events, two catalysts and attached SubPathway/interface retained"", ""title"": ""L-Threonine Degradation to Methylglyoxal: current whole BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002118/download?type=owl_markup""}, {""id"": ""PathBank:SMP0002118/PWML"", ""source_sha256"": ""fba3d72775264d6d548ea5376bc2f8c53ea3558e973f403c192dec7b31224a3a"", ""source_version"": ""Current issuing whole PWML retrieved 2026-10-11; whole document has an unbound option-prefix error at line 8903; intact SubPathway and visualization fragments inspected separately without repairing original bytes"", ""title"": ""SMP0002118 original PWML: upstream SubPathway interface"", ""url"": ""https://pathbank.org/view/SMP0002118/download?type=pwml_markup""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-032_91463f16725a	MetaCyc:THREODEHYD-CPLX	BFO:0000051	UniProtKB:P07913	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:THREODEHYD-MONOMER|MetaCyc:THREODEHYD-CPLX|UniProtKB:P07913	Native component coefficient 4 and reviewed homotetramer annotation identify the Tdh assembly; the guarded functional common name does not add an unreported assembly suffix.	"[{""reference_id"": ""MetaCyc:THREODEHYD-CPLX"", ""source_assertion"": ""Native component coefficient 4 and reviewed homotetramer annotation identify the Tdh assembly; the guarded functional common name does not add an unreported assembly suffix."", ""source_locator"": ""Protein/component[THREODEHYD-MONOMER]/coefficient=4""}, {""reference_id"": ""UniProtKB:P07913"", ""source_assertion"": ""The reviewed entry describes Tdh as a homotetramer."", ""source_locator"": ""comments[SUBUNIT]""}, {""reference_id"": ""EcoCyc:THREODEHYD-MONOMER"", ""source_assertion"": ""The exact native THREODEHYD-MONOMER protein frame has a UNIPROT unification link to P07913; this establishes the named component identity separately from the complex coefficient."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\"" and dblink-relationship=\""unification\""]/dblink-oid""}]"	"[{""id"": ""EcoCyc:THREODEHYD-MONOMER"", ""source_sha256"": ""afa3d4300c7457902236c595dca466cbf37f5e800a73464c87687db2b827a83b"", ""source_version"": ""EcoCyc 27.0 original XML; exact native protein frame and UNIPROT unification link"", ""title"": ""EcoCyc THREODEHYD-MONOMER: native component identity"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:THREODEHYD-MONOMER""}, {""id"": ""MetaCyc:THREODEHYD-CPLX"", ""source_sha256"": ""7662af5ee2d62b3fab6f5e2c0c6f46c4779bf78d6eaa4657da907233e3001944"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""MetaCyc THREODEHYD-CPLX: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:THREODEHYD-CPLX""}, {""id"": ""UniProtKB:P07913"", ""source_sha256"": ""a105aadeca1c8f232cac7d401ff6411125544fbf72dabfeca31fad825b707572"", ""source_version"": ""Issuing UniProt original; entryVersion 204; sequenceVersion 1; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""L-threonine 3-dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07913.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-033_058ebbd018da	MetaCyc:THREODEHYD-CPLX	pathwaymech:catalyzes	RHEA:13162	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:RXN-14249|EcoCyc:THREODEHYD-ENZRXN|UniProtKB:P07913	Tdh supplies the NAD-dependent threonine oxidation step. Native RXN-14249 is a composite of oxidation plus spontaneous decarboxylation, not a fourth elementary reaction.	"[{""reference_id"": ""EcoCyc:THREODEHYD-ENZRXN"", ""source_assertion"": ""The native enzymatic-reaction object links Tdh complex THREODEHYD-CPLX to composite reaction RXN-14249."", ""source_locator"": ""/ptools-xml/Enzymatic-Reaction/enzyme/Protein; /ptools-xml/Enzymatic-Reaction/reaction/Reaction""}, {""reference_id"": ""UniProtKB:P07913"", ""source_assertion"": ""The reviewed Tdh catalytic activity points to RHEA:13161, the master of the selected L-to-R oxidation."", ""source_locator"": ""comments[CATALYTIC ACTIVITY]/reactionCrossReferences""}, {""reference_id"": ""EcoCyc:RXN-14249"", ""source_assertion"": ""RXN-14249 contains THREODEHYD-RXN and THREOSPON-RXN: oxidation plus spontaneous decarboxylation, not a fourth elementary reaction."", ""source_locator"": ""/ptools-xml/Reaction/reaction-list/Reaction""}]"	"[{""id"": ""EcoCyc:RXN-14249"", ""source_sha256"": ""712fd5b073c193bb9a19f60ea7c42af45d836562cd29dd604cd2e69d26bad643"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc RXN-14249: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:RXN-14249""}, {""id"": ""EcoCyc:THREODEHYD-ENZRXN"", ""source_sha256"": ""28c7a60b3169c39a90cb9be7b289babfdc3c46373d3e2816cd73313b11b80159"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc THREODEHYD-ENZRXN: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:THREODEHYD-ENZRXN""}, {""id"": ""UniProtKB:P07913"", ""source_sha256"": ""a105aadeca1c8f232cac7d401ff6411125544fbf72dabfeca31fad825b707572"", ""source_version"": ""Issuing UniProt original; entryVersion 204; sequenceVersion 1; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""L-threonine 3-dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07913.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-034_aabe5e05fe42	NCBIProtein:AAB18566.1	pathwaymech:catalyzes	RHEA:13162	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:24651643	The purified N-terminal His-tagged YiaY/orf382 preparation showed threonine-dependent NADH formation at 340 nm. This supports an alternative oxidation activity; direct intermediate/product measurements and complete-route reconstruction were not reported.	"[{""reference_id"": ""PMID:24651643"", ""source_assertion"": ""The purified N-terminal His-tagged YiaY/orf382 preparation showed threonine-dependent NADH formation at 340 nm. This supports an alternative oxidation activity; direct intermediate/product measurements and complete-route reconstruction were not reported."", ""source_locator"": ""Publisher PDF p. 750, Enzymatic Activity Assays and Activity with Various Hydroxyl-Group-Containing Substrates; p. 752, Exploration of Substrate Spectrum and Fig. 3; p. 753, Metal Ion Binding and Cofactor Dependence""}]"	"[{""id"": ""PMID:24651643"", ""source_sha256"": ""b55e386e2aa17b7d9f51f91a91d8b8b825854200cf91fb49522df874b0305275"", ""source_version"": ""Publisher primary PDF; all eight pages inspected; His-tagged assay preparation distinct from bare sequence reference"", ""title"": ""Identification and characterization of protein encoded by orf382 as L-threonine dehydrogenase."", ""url"": ""https://www.jmb.or.kr/journal/download_pdf.php?doi=10.4014/jmb.1312.12030""}]"	"[{""description"": ""N-terminal 6×His-tagged orf382 amplified from E. coli MG1655 using AAB18566.1 as reference, expressed from pET28a(+) in BL21(DE3) and purified by Ni-NTA. The complete construct sequence was not reported; this assay endpoint does not assert identity with the bare reference or current UniProtKB:P37686 sequence."", ""endpoint"": ""subject"", ""evidence"": [{""reference_id"": ""PMID:24651643"", ""source_assertion"": ""The study cloned MG1655 orf382 using AAB18566.1 as reference, reported no mutation in the sequenced insert, expressed an N-terminal 6×His fusion in BL21(DE3), and purified the recombinant preparation by Ni-NTA."", ""source_locator"": ""Publisher PDF pp. 749–751; Materials and Methods, Molecular Cloning, Protein Expression, Purification, and Enzymatic Activity Assays; Results and Discussion, Molecular Cloning, Protein Expression, and Purification""}], ""kind"": ""experimental_construct""}]"
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-035_41b16027756b	NCBIProtein:AAB18566.1	pathwaymech:has_cofactor	CHEBI:60240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:24651643	EDTA depleted activity and affected structure of the purified construct. Its measured preparation contained 0.424 mol Fe and 0.914 mol Zn per mol protein; these values do not fix native occupancy, iron oxidation state, or a metal stoichiometry for current P37686.	"[{""reference_id"": ""PMID:24651643"", ""source_assertion"": ""EDTA depleted activity and affected structure of the purified construct. Its measured preparation contained 0.424 mol Fe and 0.914 mol Zn per mol protein; these values do not fix native occupancy, iron oxidation state, or a metal stoichiometry for current P37686."", ""source_locator"": ""pp. 752–754; metal content, EDTA treatment and structural analysis""}]"	"[{""id"": ""PMID:24651643"", ""source_sha256"": ""b55e386e2aa17b7d9f51f91a91d8b8b825854200cf91fb49522df874b0305275"", ""source_version"": ""Publisher primary PDF; all eight pages inspected; His-tagged assay preparation distinct from bare sequence reference"", ""title"": ""Identification and characterization of protein encoded by orf382 as L-threonine dehydrogenase."", ""url"": ""https://www.jmb.or.kr/journal/download_pdf.php?doi=10.4014/jmb.1312.12030""}]"	"[{""description"": ""N-terminal 6×His-tagged orf382 amplified from E. coli MG1655 using AAB18566.1 as reference, expressed from pET28a(+) in BL21(DE3) and purified by Ni-NTA. The complete construct sequence was not reported; this assay endpoint does not assert identity with the bare reference or current UniProtKB:P37686 sequence."", ""endpoint"": ""subject"", ""evidence"": [{""reference_id"": ""PMID:24651643"", ""source_assertion"": ""The study cloned MG1655 orf382 using AAB18566.1 as reference, reported no mutation in the sequenced insert, expressed an N-terminal 6×His fusion in BL21(DE3), and purified the recombinant preparation by Ni-NTA."", ""source_locator"": ""Publisher PDF pp. 749–751; Materials and Methods, Molecular Cloning, Protein Expression, Purification, and Enzymatic Activity Assays; Results and Discussion, Molecular Cloning, Protein Expression, and Purification""}], ""kind"": ""experimental_construct""}]"
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-036_a399cf4aa800	CHEBI:4735	pathwaymech:inhibits	NCBIProtein:AAB18566.1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:24651643	EDTA reduced activity and altered structural measurements in the assayed His-tagged YiaY preparation; chelation is an in-vitro treatment, not evidence of an endogenous inhibitor.	"[{""reference_id"": ""PMID:24651643"", ""source_assertion"": ""EDTA reduced activity and altered structural measurements in the assayed His-tagged YiaY preparation; chelation is an in-vitro treatment, not evidence of an endogenous inhibitor."", ""source_locator"": ""pp. 752–754; EDTA treatment and activity/structure comparisons""}]"	"[{""id"": ""PMID:24651643"", ""source_sha256"": ""b55e386e2aa17b7d9f51f91a91d8b8b825854200cf91fb49522df874b0305275"", ""source_version"": ""Publisher primary PDF; all eight pages inspected; His-tagged assay preparation distinct from bare sequence reference"", ""title"": ""Identification and characterization of protein encoded by orf382 as L-threonine dehydrogenase."", ""url"": ""https://www.jmb.or.kr/journal/download_pdf.php?doi=10.4014/jmb.1312.12030""}]"	"[{""description"": ""N-terminal 6×His-tagged orf382 amplified from E. coli MG1655 using AAB18566.1 as reference, expressed from pET28a(+) in BL21(DE3) and purified by Ni-NTA. The complete construct sequence was not reported; this assay endpoint does not assert identity with the bare reference or current UniProtKB:P37686 sequence."", ""endpoint"": ""object"", ""evidence"": [{""reference_id"": ""PMID:24651643"", ""source_assertion"": ""The study cloned MG1655 orf382 using AAB18566.1 as reference, reported no mutation in the sequenced insert, expressed an N-terminal 6×His fusion in BL21(DE3), and purified the recombinant preparation by Ni-NTA."", ""source_locator"": ""Publisher PDF pp. 749–751; Materials and Methods, Molecular Cloning, Protein Expression, Purification, and Enzymatic Activity Assays; Results and Discussion, Molecular Cloning, Protein Expression, and Purification""}], ""kind"": ""experimental_construct""}]"
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-037_d998003aaa96	MetaCyc:AMINEOXID-CPLX	BFO:0000051	UniProtKB:P46883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:AMINEOXID-MONOMER|MetaCyc:AMINEOXID-CPLX|UniProtKB:P46883	The native TynA assembly has two amine-oxidase subunits; the reviewed entry independently describes a homodimer.	"[{""reference_id"": ""MetaCyc:AMINEOXID-CPLX"", ""source_assertion"": ""The native TynA assembly has two amine-oxidase subunits; the reviewed entry independently describes a homodimer."", ""source_locator"": ""Protein/component[AMINEOXID-MONOMER]/coefficient=2""}, {""reference_id"": ""UniProtKB:P46883"", ""source_assertion"": ""TynA is annotated as a homodimer."", ""source_locator"": ""comments[SUBUNIT]""}, {""reference_id"": ""EcoCyc:AMINEOXID-MONOMER"", ""source_assertion"": ""The exact native AMINEOXID-MONOMER protein frame has a UNIPROT unification link to P46883; this establishes the named component identity separately from the complex coefficient."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\"" and dblink-relationship=\""unification\""]/dblink-oid""}]"	"[{""id"": ""EcoCyc:AMINEOXID-MONOMER"", ""source_sha256"": ""57c77aa9b40e1c952f4b264e3d7a55dd111fe6844f745830d9f26c68ea61fb86"", ""source_version"": ""EcoCyc 27.0 original XML; exact native protein frame and UNIPROT unification link"", ""title"": ""EcoCyc AMINEOXID-MONOMER: native component identity"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:AMINEOXID-MONOMER""}, {""id"": ""MetaCyc:AMINEOXID-CPLX"", ""source_sha256"": ""5218154a3acf80ae640e7c6b556942c0a49d702836c336de104da623c46f583e"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""MetaCyc AMINEOXID-CPLX: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:AMINEOXID-CPLX""}, {""id"": ""UniProtKB:P46883"", ""source_sha256"": ""79e7e4a8836d1f449023ae51cd33dd76ef74fbf710af4b3572b4f6bbbee524f9"", ""source_version"": ""Issuing UniProt original; entryVersion 206; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Primary amine oxidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46883.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-038_73de0134d07a	MetaCyc:AMINEOXID-CPLX	pathwaymech:catalyzes	RHEA:28187	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:AMACETOXID-ENZRXN|EcoCyc:THRDLCTCAT-PWY	HYPOTHETICAL TynA assignment: EcoCyc associates this complex with aminoacetone oxidation using EV-AS-NAS. This is not a demonstrated E. coli aminoacetone substrate assay or a reconstructed complete route.	"[{""reference_id"": ""EcoCyc:AMACETOXID-ENZRXN"", ""source_assertion"": ""HYPOTHETICAL TynA assignment: EcoCyc associates this complex with aminoacetone oxidation using EV-AS-NAS. This is not a demonstrated E. coli aminoacetone substrate assay or a reconstructed complete route."", ""source_locator"": ""Enzymatic-Reaction/enzyme, reaction and evidence/Evidence-Code[@frameid=\""EV-AS-NAS\""]""}, {""reference_id"": ""EcoCyc:THRDLCTCAT-PWY"", ""source_assertion"": ""The native pathway comment explicitly calls the amine-oxidase step hypothetical in E. coli."", ""source_locator"": ""Pathway/comment""}]"	"[{""id"": ""EcoCyc:AMACETOXID-ENZRXN"", ""source_sha256"": ""66591474a2865490eba059b2abfe5cbe350ba5e12f96952c256b1d10980a671a"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc AMACETOXID-ENZRXN: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:AMACETOXID-ENZRXN""}, {""id"": ""EcoCyc:THRDLCTCAT-PWY"", ""source_sha256"": ""c6dd9a962b7c73d32e4e1aa464cbf400fb85425b4cdb4dd1ef3cd37f257cf830"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc THRDLCTCAT-PWY: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:THRDLCTCAT-PWY""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-039_cea7296a1cce	MetaCyc:THREODEHYD-CPLX	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07913	Tdh localization is a reviewed cytoplasmic annotation with HAMAP inference, distinct from a direct localization assay.	"[{""reference_id"": ""UniProtKB:P07913"", ""source_assertion"": ""Tdh localization is a reviewed cytoplasmic annotation with HAMAP inference, distinct from a direct localization assay."", ""source_locator"": ""comments[SUBCELLULAR LOCATION]""}]"	"[{""id"": ""UniProtKB:P07913"", ""source_sha256"": ""a105aadeca1c8f232cac7d401ff6411125544fbf72dabfeca31fad825b707572"", ""source_version"": ""Issuing UniProt original; entryVersion 204; sequenceVersion 1; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""L-threonine 3-dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07913.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-040_b2a16e4c02a4	MetaCyc:AMINEOXID-CPLX	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P46883	The reviewed TynA protein is periplasmic. No aminoacetone export mechanism linking it to cytoplasmic Tdh is asserted.	"[{""reference_id"": ""UniProtKB:P46883"", ""source_assertion"": ""The reviewed TynA protein is periplasmic. No aminoacetone export mechanism linking it to cytoplasmic Tdh is asserted."", ""source_locator"": ""comments[SUBCELLULAR LOCATION]""}]"	"[{""id"": ""UniProtKB:P46883"", ""source_sha256"": ""79e7e4a8836d1f449023ae51cd33dd76ef74fbf710af4b3572b4f6bbbee524f9"", ""source_version"": ""Issuing UniProt original; entryVersion 206; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Primary amine oxidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46883.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-041_70d433058ba9	MetaCyc:AMINEOXID-CPLX	pathwaymech:has_cofactor	CHEBI:23378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P46883	One copper ion per subunit is annotated from experimental TynA studies.	"[{""reference_id"": ""UniProtKB:P46883"", ""source_assertion"": ""One copper ion per subunit is annotated from experimental TynA studies."", ""source_locator"": ""comments[COFACTOR], cofactorCrossReference and evidence codes""}]"	"[{""id"": ""UniProtKB:P46883"", ""source_sha256"": ""79e7e4a8836d1f449023ae51cd33dd76ef74fbf710af4b3572b4f6bbbee524f9"", ""source_version"": ""Issuing UniProt original; entryVersion 206; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Primary amine oxidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46883.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-042_e6a26f0df091	MetaCyc:AMINEOXID-CPLX	pathwaymech:has_cofactor	CHEBI:29108	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P46883	Two calcium ions per subunit are annotated from experimental TynA studies.	"[{""reference_id"": ""UniProtKB:P46883"", ""source_assertion"": ""Two calcium ions per subunit are annotated from experimental TynA studies."", ""source_locator"": ""comments[COFACTOR], cofactorCrossReference and evidence codes""}]"	"[{""id"": ""UniProtKB:P46883"", ""source_sha256"": ""79e7e4a8836d1f449023ae51cd33dd76ef74fbf710af4b3572b4f6bbbee524f9"", ""source_version"": ""Issuing UniProt original; entryVersion 206; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Primary amine oxidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46883.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-043_e546a90d7889	MetaCyc:AMINEOXID-CPLX	pathwaymech:has_cofactor	CHEBI:79027	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P46883	One topaquinone residue per subunit is annotated. Maturation and substoichiometric overexpression preparations are distinct from an assumed fully matured molecule.	"[{""reference_id"": ""UniProtKB:P46883"", ""source_assertion"": ""One topaquinone residue per subunit is annotated. Maturation and substoichiometric overexpression preparations are distinct from an assumed fully matured molecule."", ""source_locator"": ""comments[COFACTOR], cofactorCrossReference and evidence codes""}]"	"[{""id"": ""UniProtKB:P46883"", ""source_sha256"": ""79e7e4a8836d1f449023ae51cd33dd76ef74fbf710af4b3572b4f6bbbee524f9"", ""source_version"": ""Issuing UniProt original; entryVersion 206; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Primary amine oxidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46883.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-044_5a9c9e8d0a4a	MetaCyc:AMINEOXID-CPLX	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P46883	Zinc cofactor use is explicitly inferred by similarity to P12807; it is not a direct E. coli substrate-specific measurement.	"[{""reference_id"": ""UniProtKB:P46883"", ""source_assertion"": ""Zinc cofactor use is explicitly inferred by similarity to P12807; it is not a direct E. coli substrate-specific measurement."", ""source_locator"": ""comments[COFACTOR], cofactorCrossReference and evidence codes""}]"	"[{""id"": ""UniProtKB:P46883"", ""source_sha256"": ""79e7e4a8836d1f449023ae51cd33dd76ef74fbf710af4b3572b4f6bbbee524f9"", ""source_version"": ""Issuing UniProt original; entryVersion 206; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Primary amine oxidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46883.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-045_77c1501a3354	MetaCyc:AMINEOXID-CPLX	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P46883	Manganese binding (one per subunit) is explicitly inferred by similarity to Q43077; no direct E. coli occupancy measurement is claimed.	"[{""reference_id"": ""UniProtKB:P46883"", ""source_assertion"": ""Manganese binding (one per subunit) is explicitly inferred by similarity to Q43077; no direct E. coli occupancy measurement is claimed."", ""source_locator"": ""comments[COFACTOR], cofactorCrossReference and evidence codes""}]"	"[{""id"": ""UniProtKB:P46883"", ""source_sha256"": ""79e7e4a8836d1f449023ae51cd33dd76ef74fbf710af4b3572b4f6bbbee524f9"", ""source_version"": ""Issuing UniProt original; entryVersion 206; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Primary amine oxidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46883.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-046_f84f95aa04c8	PubChem:78645	pathwaymech:inhibits	MetaCyc:AMINEOXID-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9048544|UniProtKB:P46883	2-Hydrazinopyridine inhibits TynA in the cited structural/biochemical work. This protein-level inhibition does not validate hypothetical aminoacetone turnover.	"[{""reference_id"": ""UniProtKB:P46883"", ""source_assertion"": ""2-Hydrazinopyridine inhibits TynA in the cited structural/biochemical work. This protein-level inhibition does not validate hypothetical aminoacetone turnover."", ""source_locator"": ""comments[ACTIVITY REGULATION], PMID9048544""}, {""reference_id"": ""PMID:9048544"", ""source_assertion"": ""The accessible primary abstract concerns E. coli copper amine oxidase structures, including its inhibitor complex; full-text assay details were not inspected."", ""source_locator"": ""issuing primary abstract""}]"	"[{""id"": ""PMID:9048544"", ""source_sha256"": ""1c6e10d361009bf940c5984183c9ce30212e10e03162e29569fe04963436fa19"", ""source_version"": ""Europe PMC issuing primary-article core abstract; retrieved 2026-10-11; no full-text claim from this body"", ""title"": ""Catalytic mechanism of the quinoenzyme amine oxidase from Escherichia coli: exploring the reductive half-reaction."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9048544/""}, {""id"": ""UniProtKB:P46883"", ""source_sha256"": ""79e7e4a8836d1f449023ae51cd33dd76ef74fbf710af4b3572b4f6bbbee524f9"", ""source_version"": ""Issuing UniProt original; entryVersion 206; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Primary amine oxidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46883.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-047_4d72e3043237	MetaCyc:THREODEHYD-CPLX	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:2007567|UniProtKB:P07913	The reviewed entry reports two Zn(2+) per Tdh subunit and distinguishes a proposed structural site from a less tightly bound catalytic site.	"[{""reference_id"": ""UniProtKB:P07913"", ""source_assertion"": ""The reviewed entry reports two Zn(2+) per Tdh subunit and distinguishes a proposed structural site from a less tightly bound catalytic site."", ""source_locator"": ""comments[COFACTOR] note and evidence PMID2007567/9784233""}, {""reference_id"": ""PMID:2007567"", ""source_assertion"": ""The primary abstract reports one Zn(2+) per subunit in the isolated preparation, whereas the current reviewed annotation says two. These are retained as distinct occupancy claims, not reconciled by assuming an unmeasured site."", ""source_locator"": ""issuing primary abstract: neutron activation and atomic absorption analyses""}]"	"[{""id"": ""PMID:2007567"", ""source_sha256"": ""74c0972630ca6fcf4030e88b3d2110e579192862a935425a5ea16c21bd5760e2"", ""source_version"": ""Europe PMC issuing primary-article core abstract; retrieved 2026-10-11; no full-text claim from this body"", ""title"": ""L-threonine dehydrogenase from Escherichia coli. Identification of an active site cysteine residue and metal ion studies."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/2007567/""}, {""id"": ""UniProtKB:P07913"", ""source_sha256"": ""a105aadeca1c8f232cac7d401ff6411125544fbf72dabfeca31fad825b707572"", ""source_version"": ""Issuing UniProt original; entryVersion 204; sequenceVersion 1; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""L-threonine 3-dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07913.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-048_f1e3eefbfcf4	MetaCyc:THREODEHYD-CPLX	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07913	Co(2+) substitutes for zinc in the cited in-vitro Tdh preparation; this is not evidence for routine cobalt occupancy in vivo.	"[{""reference_id"": ""UniProtKB:P07913"", ""source_assertion"": ""Co(2+) substitutes for zinc in the cited in-vitro Tdh preparation; this is not evidence for routine cobalt occupancy in vivo."", ""source_locator"": ""comments[COFACTOR] note and evidence PMID2007567/9784233""}]"	"[{""id"": ""UniProtKB:P07913"", ""source_sha256"": ""a105aadeca1c8f232cac7d401ff6411125544fbf72dabfeca31fad825b707572"", ""source_version"": ""Issuing UniProt original; entryVersion 204; sequenceVersion 1; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""L-threonine 3-dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07913.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-049_601ff1fc66d4	MetaCyc:THREODEHYD-CPLX	pathwaymech:has_cofactor	CHEBI:48775	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:22411989|UniProtKB:P07913	The older reviewed annotation reports Cd(2+) exchange for zinc. The 2012 purified-enzyme study found no Cd-supported activity; preserve this preparation/assay conflict rather than asserting universal cadmium activation.	"[{""reference_id"": ""UniProtKB:P07913"", ""source_assertion"": ""The reviewed cofactor note reports Cd(2+) exchange for zinc in the older studies."", ""source_locator"": ""comments[COFACTOR]/note; PMID2007567 and PMID9784233 evidence""}, {""reference_id"": ""PMID:22411989"", ""source_assertion"": ""In the 2012 purified-enzyme metal-reconstitution comparison neither TDH nor PDF was active with Cd(II). This differs from the older Cd-exchange annotation; it does not establish universal cadmium activation."", ""source_locator"": ""//p[contains(., \""Neither enzyme was active with Mg(II), Ca(II), or Cd(II)\"")]; Results, initial metal-activity comparison; Table 1 context""}]"	"[{""id"": ""PMID:22411989"", ""source_sha256"": ""ca425303766bfd5e0861d96870a145db46f6a9453f3df28ac3d9b497f7e60fe6"", ""source_version"": ""Complete PMC primary HTML; main Methods/Results/Discussion inspected; linked supplemental Table S1/purification details not yet accessible"", ""title"": ""Mononuclear iron enzymes are primary targets of hydrogen peroxide stress."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3346116/""}, {""id"": ""UniProtKB:P07913"", ""source_sha256"": ""a105aadeca1c8f232cac7d401ff6411125544fbf72dabfeca31fad825b707572"", ""source_version"": ""Issuing UniProt original; entryVersion 204; sequenceVersion 1; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""L-threonine 3-dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07913.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-050_a9f84d888a98	MetaCyc:THREODEHYD-CPLX	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:22411989	Fe(II)-reconstituted purified Tdh was active. Native intracellular iron use was inferred from oxidative sensitivity/reconstitution; it was not established by direct active-site occupancy measurement.	"[{""reference_id"": ""PMID:22411989"", ""source_assertion"": ""Fe(II)-reconstituted purified Tdh was active. Native intracellular iron use was inferred from oxidative sensitivity/reconstitution; it was not established by direct active-site occupancy measurement."", ""source_locator"": ""Experimental Procedures, metal loading; Results first section/Table 1; Discussion Protection of Mononuclear Enzymes by Imported Manganese""}]"	"[{""id"": ""PMID:22411989"", ""source_sha256"": ""ca425303766bfd5e0861d96870a145db46f6a9453f3df28ac3d9b497f7e60fe6"", ""source_version"": ""Complete PMC primary HTML; main Methods/Results/Discussion inspected; linked supplemental Table S1/purification details not yet accessible"", ""title"": ""Mononuclear iron enzymes are primary targets of hydrogen peroxide stress."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3346116/""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-051_864ea0ef88c5	MetaCyc:THREODEHYD-CPLX	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:22411989	Mn(II)-reconstituted purified Tdh retained catalytic activity but bound threonine poorly. Intracellular manganese protection does not establish active-site occupancy or continuous pathway flux.	"[{""reference_id"": ""PMID:22411989"", ""source_assertion"": ""Mn(II)-reconstituted purified Tdh retained catalytic activity but bound threonine poorly. Intracellular manganese protection does not establish active-site occupancy or continuous pathway flux."", ""source_locator"": ""Experimental Procedures, metal loading; Results first section/Table 1; Discussion Protection of Mononuclear Enzymes by Imported Manganese""}]"	"[{""id"": ""PMID:22411989"", ""source_sha256"": ""ca425303766bfd5e0861d96870a145db46f6a9453f3df28ac3d9b497f7e60fe6"", ""source_version"": ""Complete PMC primary HTML; main Methods/Results/Discussion inspected; linked supplemental Table S1/purification details not yet accessible"", ""title"": ""Mononuclear iron enzymes are primary targets of hydrogen peroxide stress."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3346116/""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-052_fed73dd4ebc3	CHEBI:4735	pathwaymech:inhibits	MetaCyc:THREODEHYD-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:22411989|UniProtKB:P07913	EDTA inhibits Tdh in vitro and was used to remove exchangeable metals; apoenzyme instability and assay metal replacement limit interpretation as a simple native regulatory switch.	"[{""reference_id"": ""UniProtKB:P07913"", ""source_assertion"": ""EDTA inhibits Tdh in vitro and was used to remove exchangeable metals; apoenzyme instability and assay metal replacement limit interpretation as a simple native regulatory switch."", ""source_locator"": ""comments[ACTIVITY REGULATION]""}, {""reference_id"": ""PMID:22411989"", ""source_assertion"": ""Purified Tdh was chelated with EDTA before metal loading; the diluted apoenzyme rapidly became nonreactivatable."", ""source_locator"": ""Experimental Procedures, Protein Purification and In Vitro Studies of Enzyme Oxidation""}]"	"[{""id"": ""PMID:22411989"", ""source_sha256"": ""ca425303766bfd5e0861d96870a145db46f6a9453f3df28ac3d9b497f7e60fe6"", ""source_version"": ""Complete PMC primary HTML; main Methods/Results/Discussion inspected; linked supplemental Table S1/purification details not yet accessible"", ""title"": ""Mononuclear iron enzymes are primary targets of hydrogen peroxide stress."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3346116/""}, {""id"": ""UniProtKB:P07913"", ""source_sha256"": ""a105aadeca1c8f232cac7d401ff6411125544fbf72dabfeca31fad825b707572"", ""source_version"": ""Issuing UniProt original; entryVersion 204; sequenceVersion 1; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""L-threonine 3-dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07913.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-053_01e2529be194	CHEBI:16240	pathwaymech:inhibits	MetaCyc:THREODEHYD-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:22411989	Hydrogen peroxide rapidly inactivated iron-loaded Tdh and reduced measured activity in the specified stressed cells. Early damage could be rescued; prolonged stress caused increasing nonreactivatable loss.	"[{""reference_id"": ""PMID:22411989"", ""source_assertion"": ""Hydrogen peroxide rapidly inactivated iron-loaded Tdh and reduced measured activity in the specified stressed cells. Early damage could be rescued; prolonged stress caused increasing nonreactivatable loss."", ""source_locator"": ""Results; Figures 1, 3 and 5""}]"	"[{""id"": ""PMID:22411989"", ""source_sha256"": ""ca425303766bfd5e0861d96870a145db46f6a9453f3df28ac3d9b497f7e60fe6"", ""source_version"": ""Complete PMC primary HTML; main Methods/Results/Discussion inspected; linked supplemental Table S1/purification details not yet accessible"", ""title"": ""Mononuclear iron enzymes are primary targets of hydrogen peroxide stress."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3346116/""}]"	"[{""description"": ""Tdh assayed after in-vitro Fe(II) loading or in the specified peroxide-stressed E. coli preparations. Metal state and peroxide exposure are part of this claim; a fixed native metal occupancy or complete assay-construct sequence is not asserted."", ""endpoint"": ""object"", ""evidence"": [{""reference_id"": ""PMID:22411989"", ""source_assertion"": ""The work compared metal-reconstituted purified Tdh with extracts/cells of catalase- or peroxide-scavenging-deficient strains."", ""source_locator"": ""Experimental Procedures, In Vitro/In Vivo Studies of Enzyme Oxidation; Figures 1–3""}], ""kind"": ""molecular_state""}]"
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-054_c8f02ad64216	CHEBI:18320	pathwaymech:activates	MetaCyc:THREODEHYD-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:22411989	DTT together with added metal restored activity after limited peroxide exposure in vitro. This is measured rescue of an oxidized preparation, not an endogenous activator or rescue after all prolonged damage.	"[{""reference_id"": ""PMID:22411989"", ""source_assertion"": ""DTT together with added metal restored activity after limited peroxide exposure in vitro. This is measured rescue of an oxidized preparation, not an endogenous activator or rescue after all prolonged damage."", ""source_locator"": ""Experimental Procedures, In Vitro Studies; Results/Figure 3""}]"	"[{""id"": ""PMID:22411989"", ""source_sha256"": ""ca425303766bfd5e0861d96870a145db46f6a9453f3df28ac3d9b497f7e60fe6"", ""source_version"": ""Complete PMC primary HTML; main Methods/Results/Discussion inspected; linked supplemental Table S1/purification details not yet accessible"", ""title"": ""Mononuclear iron enzymes are primary targets of hydrogen peroxide stress."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3346116/""}]"	"[{""description"": ""Tdh assayed after in-vitro Fe(II) loading or in the specified peroxide-stressed E. coli preparations. Metal state and peroxide exposure are part of this claim; a fixed native metal occupancy or complete assay-construct sequence is not asserted."", ""endpoint"": ""object"", ""evidence"": [{""reference_id"": ""PMID:22411989"", ""source_assertion"": ""The work compared metal-reconstituted purified Tdh with extracts/cells of catalase- or peroxide-scavenging-deficient strains."", ""source_locator"": ""Experimental Procedures, In Vitro/In Vivo Studies of Enzyme Oxidation; Figures 1–3""}], ""kind"": ""molecular_state""}]"
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-055_973212f931a1	CHEBI:63213	pathwaymech:activates	MetaCyc:THREODEHYD-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:22411989	TCEP together with added metal restored activity after limited peroxide exposure in vitro. This is measured rescue of an oxidized preparation, not an endogenous activator or rescue after all prolonged damage.	"[{""reference_id"": ""PMID:22411989"", ""source_assertion"": ""TCEP together with added metal restored activity after limited peroxide exposure in vitro. This is measured rescue of an oxidized preparation, not an endogenous activator or rescue after all prolonged damage."", ""source_locator"": ""Experimental Procedures, In Vitro Studies; Results/Figure 3""}]"	"[{""id"": ""PMID:22411989"", ""source_sha256"": ""ca425303766bfd5e0861d96870a145db46f6a9453f3df28ac3d9b497f7e60fe6"", ""source_version"": ""Complete PMC primary HTML; main Methods/Results/Discussion inspected; linked supplemental Table S1/purification details not yet accessible"", ""title"": ""Mononuclear iron enzymes are primary targets of hydrogen peroxide stress."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3346116/""}]"	"[{""description"": ""Tdh assayed after in-vitro Fe(II) loading or in the specified peroxide-stressed E. coli preparations. Metal state and peroxide exposure are part of this claim; a fixed native metal occupancy or complete assay-construct sequence is not asserted."", ""endpoint"": ""object"", ""evidence"": [{""reference_id"": ""PMID:22411989"", ""source_assertion"": ""The work compared metal-reconstituted purified Tdh with extracts/cells of catalase- or peroxide-scavenging-deficient strains."", ""source_locator"": ""Experimental Procedures, In Vitro/In Vivo Studies of Enzyme Oxidation; Figures 1–3""}], ""kind"": ""molecular_state""}]"
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-056_cf0e412d32be	EcoCyc:CPLX0-1521	BFO:0000051	UniProtKB:P0ABT2	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-1521|EcoCyc:EG11415-MONOMER	The native EcoCyc complex lists this protein component with coefficient 12. This assembly annotation does not establish that every promoter assay used this oligomeric state.	"[{""reference_id"": ""EcoCyc:CPLX0-1521"", ""source_assertion"": ""The native EcoCyc complex lists this protein component with coefficient 12. This assembly annotation does not establish that every promoter assay used this oligomeric state."", ""source_locator"": ""Protein/component and coefficient""}, {""reference_id"": ""EcoCyc:EG11415-MONOMER"", ""source_assertion"": ""The exact native EG11415-MONOMER protein frame has a UNIPROT unification link to P0ABT2; this establishes the named component identity separately from the complex coefficient."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\"" and dblink-relationship=\""unification\""]/dblink-oid""}]"	"[{""id"": ""EcoCyc:CPLX0-1521"", ""source_sha256"": ""39d9767ea3ffaed4fd9548eee3574bfe4bba942cbd049d19a329f8381833f9fc"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc CPLX0-1521: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:CPLX0-1521""}, {""id"": ""EcoCyc:EG11415-MONOMER"", ""source_sha256"": ""c5345b329c9acda98260e66bfcc5c00ccd14c510153fb38546ac98d509921d07"", ""source_version"": ""EcoCyc 27.0 original XML; exact native protein frame and UNIPROT unification link"", ""title"": ""EcoCyc EG11415-MONOMER: native component identity"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:EG11415-MONOMER""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-057_5ab995a8805b	EcoCyc:CPLX0-7756	BFO:0000051	UniProtKB:P0AF63	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-7756|EcoCyc:EG11212-MONOMER	The native EcoCyc complex lists this protein component with coefficient 2. This assembly annotation does not establish that every promoter assay used this oligomeric state.	"[{""reference_id"": ""EcoCyc:CPLX0-7756"", ""source_assertion"": ""The native EcoCyc complex lists this protein component with coefficient 2. This assembly annotation does not establish that every promoter assay used this oligomeric state."", ""source_locator"": ""Protein/component and coefficient""}, {""reference_id"": ""EcoCyc:EG11212-MONOMER"", ""source_assertion"": ""The exact native EG11212-MONOMER protein frame has a UNIPROT unification link to P0AF63; this establishes the named component identity separately from the complex coefficient."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\"" and dblink-relationship=\""unification\""]/dblink-oid""}]"	"[{""id"": ""EcoCyc:CPLX0-7756"", ""source_sha256"": ""953e56c15ec4cbe402acdc22dd30dc18f4d79e0e7ba97b110d2595ffa457e1cf"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc CPLX0-7756: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:CPLX0-7756""}, {""id"": ""EcoCyc:EG11212-MONOMER"", ""source_sha256"": ""27a2c643d03769fceb6d45145e7c12356e587af70801913db51bc0ef802de5d6"", ""source_version"": ""EcoCyc 27.0 original XML; exact native protein frame and UNIPROT unification link"", ""title"": ""EcoCyc EG11212-MONOMER: native component identity"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:EG11212-MONOMER""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-058_b04363dad7ab	EcoCyc:CPLX0-7797	BFO:0000051	UniProtKB:P0A9E5	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-7797|EcoCyc:PD00197	The native EcoCyc complex lists this protein component with coefficient 2. This assembly annotation does not establish that every promoter assay used this oligomeric state.	"[{""reference_id"": ""EcoCyc:CPLX0-7797"", ""source_assertion"": ""The native EcoCyc complex lists this protein component with coefficient 2. This assembly annotation does not establish that every promoter assay used this oligomeric state."", ""source_locator"": ""Protein/component and coefficient""}, {""reference_id"": ""EcoCyc:PD00197"", ""source_assertion"": ""The exact native PD00197 protein frame has a UNIPROT unification link to P0A9E5; this establishes the named component identity separately from the complex coefficient."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\"" and dblink-relationship=\""unification\""]/dblink-oid""}]"	"[{""id"": ""EcoCyc:CPLX0-7797"", ""source_sha256"": ""dbc83229f049a23bdb15689c1ae8ba13def540b5eb6434874812ee26edd01a5d"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc CPLX0-7797: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:CPLX0-7797""}, {""id"": ""EcoCyc:PD00197"", ""source_sha256"": ""97fa8ecdc640c4cc36cb0ce4417a405b40bfc06e0afb4ea129e6a35701941497"", ""source_version"": ""EcoCyc 27.0 original XML; exact native protein frame and UNIPROT unification link"", ""title"": ""EcoCyc PD00197: native component identity"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:PD00197""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-059_e3f6ba518e18	EcoCyc:CPLX0-7797	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-7797|UniProtKB:P0A9E5	The reviewed FNR entry assigns one [4Fe-4S] cluster per subunit; anaerobic cluster acquisition favors its active dimer, whereas oxygen disrupts this state.	"[{""reference_id"": ""UniProtKB:P0A9E5"", ""source_assertion"": ""The reviewed FNR entry assigns one [4Fe-4S] cluster per subunit."", ""source_locator"": ""results[0]/comments[COFACTOR]""}, {""reference_id"": ""EcoCyc:CPLX0-7797"", ""source_assertion"": ""The native FNR complex comment describes anaerobic [4Fe-4S] acquisition and dimer activation; oxygen converts the cluster and promotes dimer disassembly."", ""source_locator"": ""/ptools-xml/Protein/comment; paragraph beginning \""The cellular concentration of FNR\""""}]"	"[{""id"": ""EcoCyc:CPLX0-7797"", ""source_sha256"": ""dbc83229f049a23bdb15689c1ae8ba13def540b5eb6434874812ee26edd01a5d"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc CPLX0-7797: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:CPLX0-7797""}, {""id"": ""UniProtKB:P0A9E5"", ""source_sha256"": ""151ea39575605a228684f5f811c0443bb8dfd650c93d5f93b34a6e830c8d60aa"", ""source_version"": ""Issuing UniProt original; entryVersion 145; sequenceVersion 1; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""Fumarate and nitrate reduction regulatory protein"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A83333%29%20AND%20%28gene_exact%3Afnr%29&format=json&size=25""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-060_881bc63e4014	EcoCyc:CPLX0-7756	pathwaymech:has_cofactor	CHEBI:190135	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-7756|UniProtKB:P0AF63	The reviewed E. coli NsrR annotation assigns a [2Fe-2S] cluster with curator inference. Native commentary cites some physical-state work in S. coelicolor; this is not a direct E. coli tynA-promoter metal assay.	"[{""reference_id"": ""UniProtKB:P0AF63"", ""source_assertion"": ""The reviewed E. coli NsrR entry assigns a [2Fe-2S] cluster with curator inference ECO:0000305."", ""source_locator"": ""results[0]/comments[COFACTOR]""}, {""reference_id"": ""EcoCyc:CPLX0-7756"", ""source_assertion"": ""Native NsrR commentary describes homodimer/DNA-binding physical-state work in S. coelicolor; it is not a direct E. coli tynA-promoter metal assay."", ""source_locator"": ""/ptools-xml/Protein/comment; paragraph beginning \""The binding site for NsrR\"" and citing PMID18989365""}]"	"[{""id"": ""EcoCyc:CPLX0-7756"", ""source_sha256"": ""953e56c15ec4cbe402acdc22dd30dc18f4d79e0e7ba97b110d2595ffa457e1cf"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc CPLX0-7756: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:CPLX0-7756""}, {""id"": ""UniProtKB:P0AF63"", ""source_sha256"": ""9e07826a5a802a71b4ba4135599ec5bcd92a47990a5ee0450bc3dae22b639184"", ""source_version"": ""Issuing UniProt original; entryVersion 140; sequenceVersion 1; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""HTH-type transcriptional repressor NsrR"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A83333%29%20AND%20%28gene_exact%3AnsrR%29&format=json&size=25""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-061_97a27404a675	UniProtKB:P0A769	pathwaymech:regulates	MetaCyc:THREODEHYD-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:22411989	MntH supported retention of measured Tdh activity under the study's chronic peroxide-stress conditions. This is indirect protection through manganese import/iron handling, not direct Tdh binding or measured complete pathway flux.	"[{""reference_id"": ""PMID:22411989"", ""source_assertion"": ""MntH supported retention of measured Tdh activity under the study's chronic peroxide-stress conditions. This is indirect protection through manganese import/iron handling, not direct Tdh binding or measured complete pathway flux."", ""source_locator"": ""Results/Figures 7 and 9; Discussion Protection of Mononuclear Enzymes by Imported Manganese""}]"	"[{""id"": ""PMID:22411989"", ""source_sha256"": ""ca425303766bfd5e0861d96870a145db46f6a9453f3df28ac3d9b497f7e60fe6"", ""source_version"": ""Complete PMC primary HTML; main Methods/Results/Discussion inspected; linked supplemental Table S1/purification details not yet accessible"", ""title"": ""Mononuclear iron enzymes are primary targets of hydrogen peroxide stress."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3346116/""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-062_d0aedb5d0c16	EcoCyc:CPLX0-1521	pathwaymech:regulates	MetaCyc:THREODEHYD-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:22411989	Dps supported retention of measured Tdh activity under the study's chronic peroxide-stress conditions. This is indirect protection through manganese import/iron handling, not direct Tdh binding or measured complete pathway flux.	"[{""reference_id"": ""PMID:22411989"", ""source_assertion"": ""Dps supported retention of measured Tdh activity under the study's chronic peroxide-stress conditions. This is indirect protection through manganese import/iron handling, not direct Tdh binding or measured complete pathway flux."", ""source_locator"": ""Results/Figures 7 and 9; Discussion Protection of Mononuclear Enzymes by Imported Manganese""}]"	"[{""id"": ""PMID:22411989"", ""source_sha256"": ""ca425303766bfd5e0861d96870a145db46f6a9453f3df28ac3d9b497f7e60fe6"", ""source_version"": ""Complete PMC primary HTML; main Methods/Results/Discussion inspected; linked supplemental Table S1/purification details not yet accessible"", ""title"": ""Mononuclear iron enzymes are primary targets of hydrogen peroxide stress."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3346116/""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-063_970695584bf4	CHEBI:29035	pathwaymech:regulates	MetaCyc:THREODEHYD-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:22411989	Supplemental manganese protected measured Tdh activity in peroxide-stressed cells, including the Dps-deficient comparison. The authors explicitly did not physically demonstrate intracellular active-site manganese.	"[{""reference_id"": ""PMID:22411989"", ""source_assertion"": ""Supplemental manganese protected measured Tdh activity in peroxide-stressed cells, including the Dps-deficient comparison. The authors explicitly did not physically demonstrate intracellular active-site manganese."", ""source_locator"": ""Figures 7/9B and Discussion Protection of Mononuclear Enzymes by Imported Manganese""}]"	"[{""id"": ""PMID:22411989"", ""source_sha256"": ""ca425303766bfd5e0861d96870a145db46f6a9453f3df28ac3d9b497f7e60fe6"", ""source_version"": ""Complete PMC primary HTML; main Methods/Results/Discussion inspected; linked supplemental Table S1/purification details not yet accessible"", ""title"": ""Mononuclear iron enzymes are primary targets of hydrogen peroxide stress."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3346116/""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-064_f746bbb0eb10	UniProtKB:P0AGE4	pathwaymech:catalyzes	RHEA:70001	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AGE4	SstT is assigned the physiological inward sodium/threonine symport direction. The purified 2002 experiment measured serine uptake and threonine competition; it did not directly measure threonine transport kinetics.	"[{""reference_id"": ""UniProtKB:P0AGE4"", ""source_assertion"": ""SstT is assigned the physiological inward sodium/threonine symport direction. The purified 2002 experiment measured serine uptake and threonine competition; it did not directly measure threonine transport kinetics."", ""source_locator"": ""comments[CATALYTIC ACTIVITY]/physiologicalReactions and FUNCTION""}]"	"[{""id"": ""UniProtKB:P0AGE4"", ""source_sha256"": ""7f4d92e73f3fafe6ecc404ed4558d4399a2fb8acdbf212e5c9c923d9aaba8a5e"", ""source_version"": ""Issuing UniProt original; entryVersion 132; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Serine/threonine transporter SstT"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AGE4.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-065_763d36f3b488	UniProtKB:P0AGE4	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AGE4	The reviewed transporter is located in the cell inner membrane.	"[{""reference_id"": ""UniProtKB:P0AGE4"", ""source_assertion"": ""The reviewed transporter is located in the cell inner membrane."", ""source_locator"": ""comments[SUBCELLULAR LOCATION]""}]"	"[{""id"": ""UniProtKB:P0AGE4"", ""source_sha256"": ""7f4d92e73f3fafe6ecc404ed4558d4399a2fb8acdbf212e5c9c923d9aaba8a5e"", ""source_version"": ""Issuing UniProt original; entryVersion 132; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Serine/threonine transporter SstT"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AGE4.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-066_c38e56aaf620	RHEA:70001	RO:0002413	RHEA:13162	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:THRDLCTCAT-PWY	Threonine uptake can supply the oxidation substrate in the relevant physiological context; this connection does not assert concurrent expression or demonstrated complete-route flux.	"[{""reference_id"": ""EcoCyc:THRDLCTCAT-PWY"", ""source_assertion"": ""Threonine uptake can supply the oxidation substrate in the relevant physiological context; this connection does not assert concurrent expression or demonstrated complete-route flux."", ""source_locator"": ""/ptools-xml/Pathway/comment; paragraph beginning \""E. coli has three systems that can transport threonine\"", naming YGJU-MONOMER, ABC-15-CPLX and TDCC-MONOMER""}]"	"[{""id"": ""EcoCyc:THRDLCTCAT-PWY"", ""source_sha256"": ""c6dd9a962b7c73d32e4e1aa464cbf400fb85425b4cdb4dd1ef3cd37f257cf830"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc THRDLCTCAT-PWY: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:THRDLCTCAT-PWY""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-067_e8fc7871dc20	UniProtKB:P0AAD8	pathwaymech:catalyzes	RHEA:28885	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AAD8	TdcC is assigned physiological inward proton/threonine symport. Its anaerobically induced uptake context does not imply simultaneous aerobic terminal aminoacetone oxidation.	"[{""reference_id"": ""UniProtKB:P0AAD8"", ""source_assertion"": ""TdcC is assigned physiological inward proton/threonine symport. Its anaerobically induced uptake context does not imply simultaneous aerobic terminal aminoacetone oxidation."", ""source_locator"": ""comments[CATALYTIC ACTIVITY]/physiologicalReactions and FUNCTION""}]"	"[{""id"": ""UniProtKB:P0AAD8"", ""source_sha256"": ""8da0289e1e40808804d0fb3106b9078c8e133ee98a47223883dd4e7a74752ff6"", ""source_version"": ""Issuing UniProt original; entryVersion 130; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Threonine/serine transporter TdcC"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AAD8.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-068_c6829f8cd4b8	UniProtKB:P0AAD8	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AAD8	The reviewed transporter is located in the cell inner membrane.	"[{""reference_id"": ""UniProtKB:P0AAD8"", ""source_assertion"": ""The reviewed transporter is located in the cell inner membrane."", ""source_locator"": ""comments[SUBCELLULAR LOCATION]""}]"	"[{""id"": ""UniProtKB:P0AAD8"", ""source_sha256"": ""8da0289e1e40808804d0fb3106b9078c8e133ee98a47223883dd4e7a74752ff6"", ""source_version"": ""Issuing UniProt original; entryVersion 130; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Threonine/serine transporter TdcC"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AAD8.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-069_af2e508a1fea	RHEA:28885	RO:0002413	RHEA:13162	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:THRDLCTCAT-PWY	Threonine uptake can supply the oxidation substrate in the relevant physiological context; this connection does not assert concurrent expression or demonstrated complete-route flux.	"[{""reference_id"": ""EcoCyc:THRDLCTCAT-PWY"", ""source_assertion"": ""Threonine uptake can supply the oxidation substrate in the relevant physiological context; this connection does not assert concurrent expression or demonstrated complete-route flux."", ""source_locator"": ""/ptools-xml/Pathway/comment; paragraph beginning \""E. coli has three systems that can transport threonine\"", naming YGJU-MONOMER, ABC-15-CPLX and TDCC-MONOMER""}]"	"[{""id"": ""EcoCyc:THRDLCTCAT-PWY"", ""source_sha256"": ""c6dd9a962b7c73d32e4e1aa464cbf400fb85425b4cdb4dd1ef3cd37f257cf830"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc THRDLCTCAT-PWY: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:THRDLCTCAT-PWY""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-070_d1596803153c	MetaCyc:ABC-15-CPLX	pathwaymech:enables	GO:0015195	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:ABC-15-CPLX	The LIV-I transporter is reported to take up threonine in addition to its principal branched-chain substrates. Its ATP-dependent transport context is retained without inventing a threonine-specific ATP-hydrolysis stoichiometry.	"[{""reference_id"": ""EcoCyc:ABC-15-CPLX"", ""source_assertion"": ""The LIV-I transporter is reported to take up threonine in addition to its principal branched-chain substrates. Its ATP-dependent transport context is retained without inventing a threonine-specific ATP-hydrolysis stoichiometry."", ""source_locator"": ""Protein/comment; components and linked transport activities""}]"	"[{""id"": ""EcoCyc:ABC-15-CPLX"", ""source_sha256"": ""e809605fff79e5e63cc02ddb50956a14d2cba55103df3db15dddab5cfa6b0125"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc ABC-15-CPLX: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:ABC-15-CPLX""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-071_f31c7e4c48e7	MetaCyc:ABC-15-CPLX	BFO:0000051	UniProtKB:P22731	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:ABC-15-CPLX|EcoCyc:LIVF-MONOMER	The native LIV-I complex includes this exact LivF/LivG/LivH/LivM/LivJ component with coefficient 1. LivJ is retained; the alternative LivK binding protein is not substituted.	"[{""reference_id"": ""EcoCyc:ABC-15-CPLX"", ""source_assertion"": ""The native LIV-I complex includes this exact LivF/LivG/LivH/LivM/LivJ component with coefficient 1. LivJ is retained; the alternative LivK binding protein is not substituted."", ""source_locator"": ""Protein/component/coefficient""}, {""reference_id"": ""EcoCyc:LIVF-MONOMER"", ""source_assertion"": ""The exact native LIVF-MONOMER protein frame has a UNIPROT unification link to P22731; this establishes the named component identity separately from the complex coefficient."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\"" and dblink-relationship=\""unification\""]/dblink-oid""}]"	"[{""id"": ""EcoCyc:ABC-15-CPLX"", ""source_sha256"": ""e809605fff79e5e63cc02ddb50956a14d2cba55103df3db15dddab5cfa6b0125"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc ABC-15-CPLX: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:ABC-15-CPLX""}, {""id"": ""EcoCyc:LIVF-MONOMER"", ""source_sha256"": ""d69e06ce5fc34eafd2eb99bd486f93af2b16f767f3c16e66dbd9992261a7dd09"", ""source_version"": ""EcoCyc 27.0 original XML; exact native protein frame and UNIPROT unification link"", ""title"": ""EcoCyc LIVF-MONOMER: native component identity"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:LIVF-MONOMER""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-072_9ff56d17a0af	MetaCyc:ABC-15-CPLX	BFO:0000051	UniProtKB:P0A9S7	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:ABC-15-CPLX|EcoCyc:LIVG-MONOMER	The native LIV-I complex includes this exact LivF/LivG/LivH/LivM/LivJ component with coefficient 1. LivJ is retained; the alternative LivK binding protein is not substituted.	"[{""reference_id"": ""EcoCyc:ABC-15-CPLX"", ""source_assertion"": ""The native LIV-I complex includes this exact LivF/LivG/LivH/LivM/LivJ component with coefficient 1. LivJ is retained; the alternative LivK binding protein is not substituted."", ""source_locator"": ""Protein/component/coefficient""}, {""reference_id"": ""EcoCyc:LIVG-MONOMER"", ""source_assertion"": ""The exact native LIVG-MONOMER protein frame has a UNIPROT unification link to P0A9S7; this establishes the named component identity separately from the complex coefficient."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\"" and dblink-relationship=\""unification\""]/dblink-oid""}]"	"[{""id"": ""EcoCyc:ABC-15-CPLX"", ""source_sha256"": ""e809605fff79e5e63cc02ddb50956a14d2cba55103df3db15dddab5cfa6b0125"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc ABC-15-CPLX: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:ABC-15-CPLX""}, {""id"": ""EcoCyc:LIVG-MONOMER"", ""source_sha256"": ""1872495afad72be5439bc3065a6a0def2d03e37c0694bec8382451e8da7f7cf1"", ""source_version"": ""EcoCyc 27.0 original XML; exact native protein frame and UNIPROT unification link"", ""title"": ""EcoCyc LIVG-MONOMER: native component identity"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:LIVG-MONOMER""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-073_cdf94cf5b937	MetaCyc:ABC-15-CPLX	BFO:0000051	UniProtKB:P0AEX7	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:ABC-15-CPLX|EcoCyc:LIVH-MONOMER	The native LIV-I complex includes this exact LivF/LivG/LivH/LivM/LivJ component with coefficient 1. LivJ is retained; the alternative LivK binding protein is not substituted.	"[{""reference_id"": ""EcoCyc:ABC-15-CPLX"", ""source_assertion"": ""The native LIV-I complex includes this exact LivF/LivG/LivH/LivM/LivJ component with coefficient 1. LivJ is retained; the alternative LivK binding protein is not substituted."", ""source_locator"": ""Protein/component/coefficient""}, {""reference_id"": ""EcoCyc:LIVH-MONOMER"", ""source_assertion"": ""The exact native LIVH-MONOMER protein frame has a UNIPROT unification link to P0AEX7; this establishes the named component identity separately from the complex coefficient."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\"" and dblink-relationship=\""unification\""]/dblink-oid""}]"	"[{""id"": ""EcoCyc:ABC-15-CPLX"", ""source_sha256"": ""e809605fff79e5e63cc02ddb50956a14d2cba55103df3db15dddab5cfa6b0125"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc ABC-15-CPLX: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:ABC-15-CPLX""}, {""id"": ""EcoCyc:LIVH-MONOMER"", ""source_sha256"": ""6f16e8f50f2ba082ae6fe6e143f592ce49e8989c37cc1e8f592eea9856fcf1d3"", ""source_version"": ""EcoCyc 27.0 original XML; exact native protein frame and UNIPROT unification link"", ""title"": ""EcoCyc LIVH-MONOMER: native component identity"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:LIVH-MONOMER""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-074_e85c838dd0b1	MetaCyc:ABC-15-CPLX	BFO:0000051	UniProtKB:P22729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:ABC-15-CPLX|EcoCyc:LIVM-MONOMER	The native LIV-I complex includes this exact LivF/LivG/LivH/LivM/LivJ component with coefficient 1. LivJ is retained; the alternative LivK binding protein is not substituted.	"[{""reference_id"": ""EcoCyc:ABC-15-CPLX"", ""source_assertion"": ""The native LIV-I complex includes this exact LivF/LivG/LivH/LivM/LivJ component with coefficient 1. LivJ is retained; the alternative LivK binding protein is not substituted."", ""source_locator"": ""Protein/component/coefficient""}, {""reference_id"": ""EcoCyc:LIVM-MONOMER"", ""source_assertion"": ""The exact native LIVM-MONOMER protein frame has a UNIPROT unification link to P22729; this establishes the named component identity separately from the complex coefficient."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\"" and dblink-relationship=\""unification\""]/dblink-oid""}]"	"[{""id"": ""EcoCyc:ABC-15-CPLX"", ""source_sha256"": ""e809605fff79e5e63cc02ddb50956a14d2cba55103df3db15dddab5cfa6b0125"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc ABC-15-CPLX: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:ABC-15-CPLX""}, {""id"": ""EcoCyc:LIVM-MONOMER"", ""source_sha256"": ""04558bf612a1220787606a937203f70ba0a63f73d36b7b9e4675c8a113a3de41"", ""source_version"": ""EcoCyc 27.0 original XML; exact native protein frame and UNIPROT unification link"", ""title"": ""EcoCyc LIVM-MONOMER: native component identity"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:LIVM-MONOMER""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-075_7c7c278c6471	MetaCyc:ABC-15-CPLX	BFO:0000051	UniProtKB:P0AD96	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:ABC-15-CPLX|EcoCyc:LIVJ-MONOMER	The native LIV-I complex includes this exact LivF/LivG/LivH/LivM/LivJ component with coefficient 1. LivJ is retained; the alternative LivK binding protein is not substituted.	"[{""reference_id"": ""EcoCyc:ABC-15-CPLX"", ""source_assertion"": ""The native LIV-I complex includes this exact LivF/LivG/LivH/LivM/LivJ component with coefficient 1. LivJ is retained; the alternative LivK binding protein is not substituted."", ""source_locator"": ""Protein/component/coefficient""}, {""reference_id"": ""EcoCyc:LIVJ-MONOMER"", ""source_assertion"": ""The exact native LIVJ-MONOMER protein frame has a UNIPROT unification link to P0AD96; this establishes the named component identity separately from the complex coefficient."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\"" and dblink-relationship=\""unification\""]/dblink-oid""}]"	"[{""id"": ""EcoCyc:ABC-15-CPLX"", ""source_sha256"": ""e809605fff79e5e63cc02ddb50956a14d2cba55103df3db15dddab5cfa6b0125"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc ABC-15-CPLX: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:ABC-15-CPLX""}, {""id"": ""EcoCyc:LIVJ-MONOMER"", ""source_sha256"": ""3d6bf39a5ed4d7edd4bc27e286ea4e51d35827e514424dfd8fee49c7bcc519fa"", ""source_version"": ""EcoCyc 27.0 original XML; exact native protein frame and UNIPROT unification link"", ""title"": ""EcoCyc LIVJ-MONOMER: native component identity"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:LIVJ-MONOMER""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-076_137cfdad451b	UniProtKB:P0AEX7	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AEX7	The reviewed Liv component has this membrane/periplasmic localization; binding-protein and permease roles remain distinct.	"[{""reference_id"": ""UniProtKB:P0AEX7"", ""source_assertion"": ""The reviewed Liv component has this membrane/periplasmic localization; binding-protein and permease roles remain distinct."", ""source_locator"": ""comments[SUBCELLULAR LOCATION] and FUNCTION""}]"	"[{""id"": ""UniProtKB:P0AEX7"", ""source_sha256"": ""dadc81da20c0b5222b1d73fe844a443f9941cdbb7f127e08b2391b1ad3175127"", ""source_version"": ""Issuing UniProt original; entryVersion 131; sequenceVersion 1; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""High-affinity branched-chain amino acid transport system permease protein LivH"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AEX7.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-077_ab191456e036	UniProtKB:P22729	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P22729	The reviewed Liv component has this membrane/periplasmic localization; binding-protein and permease roles remain distinct.	"[{""reference_id"": ""UniProtKB:P22729"", ""source_assertion"": ""The reviewed Liv component has this membrane/periplasmic localization; binding-protein and permease roles remain distinct."", ""source_locator"": ""comments[SUBCELLULAR LOCATION] and FUNCTION""}]"	"[{""id"": ""UniProtKB:P22729"", ""source_sha256"": ""8579aced6306df9ae9a07c649eece8a76b0c15bb18b668d4e59173208739de22"", ""source_version"": ""Issuing UniProt original; entryVersion 161; sequenceVersion 2; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""High-affinity branched-chain amino acid transport system permease protein LivM"", ""url"": ""https://rest.uniprot.org/uniprotkb/P22729.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-078_0eb2279c4cdf	UniProtKB:P0AD96	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AD96	The reviewed Liv component has this membrane/periplasmic localization; binding-protein and permease roles remain distinct.	"[{""reference_id"": ""UniProtKB:P0AD96"", ""source_assertion"": ""The reviewed Liv component has this membrane/periplasmic localization; binding-protein and permease roles remain distinct."", ""source_locator"": ""comments[SUBCELLULAR LOCATION] and FUNCTION""}]"	"[{""id"": ""UniProtKB:P0AD96"", ""source_sha256"": ""24f1315b58a9a15b1d214b3ab90e10cda4c2ed4f6a757d6dbc1e10f76fa22684"", ""source_version"": ""Issuing UniProt original; entryVersion 137; sequenceVersion 1; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""Leu/Ile/Val-binding protein"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AD96.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-079_4e3263178045	GO:0015195	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:ABC-15-CPLX	LIV-I is an ATP-dependent uptake system containing the LivF/LivG ATP-binding subunits. This nonstoichiometric activity edge does not assert a complete threonine-specific ATP equation.	"[{""reference_id"": ""EcoCyc:ABC-15-CPLX"", ""source_assertion"": ""LIV-I is an ATP-dependent uptake system containing the LivF/LivG ATP-binding subunits. This nonstoichiometric activity edge does not assert a complete threonine-specific ATP equation."", ""source_locator"": ""Protein/comment and native linked transport activities""}]"	"[{""id"": ""EcoCyc:ABC-15-CPLX"", ""source_sha256"": ""e809605fff79e5e63cc02ddb50956a14d2cba55103df3db15dddab5cfa6b0125"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc ABC-15-CPLX: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:ABC-15-CPLX""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-080_4c116cd667b8	GO:0015195	RO:0002233	CHEBI:57926	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:ABC-15-CPLX	Threonine is a reported LIV-I uptake substrate; the shared chemical node denotes its identity, not a new extracellular chemical species.	"[{""reference_id"": ""EcoCyc:ABC-15-CPLX"", ""source_assertion"": ""Threonine is a reported LIV-I uptake substrate; the shared chemical node denotes its identity, not a new extracellular chemical species."", ""source_locator"": ""Protein/comment: LIV-I substrate scope""}]"	"[{""id"": ""EcoCyc:ABC-15-CPLX"", ""source_sha256"": ""e809605fff79e5e63cc02ddb50956a14d2cba55103df3db15dddab5cfa6b0125"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc ABC-15-CPLX: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:ABC-15-CPLX""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-081_1636074997af	GO:0015195	RO:0002413	RHEA:13162	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:ABC-15-CPLX	LIV-I uptake can supply threonine to the core oxidation; its conditional expression and ATP requirement do not demonstrate complete degradation-III flux.	"[{""reference_id"": ""EcoCyc:ABC-15-CPLX"", ""source_assertion"": ""LIV-I uptake can supply threonine to the core oxidation; its conditional expression and ATP requirement do not demonstrate complete degradation-III flux."", ""source_locator"": ""Protein/comment; pathway threonine input""}]"	"[{""id"": ""EcoCyc:ABC-15-CPLX"", ""source_sha256"": ""e809605fff79e5e63cc02ddb50956a14d2cba55103df3db15dddab5cfa6b0125"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc ABC-15-CPLX: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:ABC-15-CPLX""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-082_87af6e057c8f	Entrez:948139	pathwaymech:enables	UniProtKB:P07913	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Entrez:948139|UniProtKB:P07913	The issuing gene and reviewed protein records identify this gene-product relation in the MG1655 reference. Experimental derivative strain scope is stated separately on regulatory edges.	"[{""reference_id"": ""Entrez:948139"", ""source_assertion"": ""The issuing gene and reviewed protein records identify this gene-product relation in the MG1655 reference. Experimental derivative strain scope is stated separately on regulatory edges."", ""source_locator"": ""/Entrezgene-Set/Entrezgene/Entrezgene_locus/Gene-commentary/Gene-commentary_products/Gene-commentary/Gene-commentary_source/Other-source/Other-source_src/Dbtag[Dbtag_db=\""UniProtKB/Swiss-Prot\""]/Dbtag_tag/Object-id/Object-id_str; Entrezgene_gene/Gene-ref/Gene-ref_locus""}, {""reference_id"": ""UniProtKB:P07913"", ""source_assertion"": ""The reviewed entry includes this GeneID association."", ""source_locator"": ""uniProtKBCrossReferences[GeneID]""}]"	"[{""id"": ""Entrez:948139"", ""source_sha256"": ""fc4d1c66db725508693ff82a0d6b5e428f6fe8954b3fa35f4147e5a5b6aadedb"", ""source_version"": ""Retrieved 2026-10-12; exact MG1655 gene original, native locus name"", ""title"": ""NCBI Gene 948139: tdh"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=gene&id=948139&rettype=xml""}, {""id"": ""UniProtKB:P07913"", ""source_sha256"": ""a105aadeca1c8f232cac7d401ff6411125544fbf72dabfeca31fad825b707572"", ""source_version"": ""Issuing UniProt original; entryVersion 204; sequenceVersion 1; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""L-threonine 3-dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07913.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-083_47250b24f3ad	Entrez:945939	pathwaymech:enables	UniProtKB:P46883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Entrez:945939|UniProtKB:P46883	The issuing gene and reviewed protein records identify this gene-product relation in the MG1655 reference. Experimental derivative strain scope is stated separately on regulatory edges.	"[{""reference_id"": ""Entrez:945939"", ""source_assertion"": ""The issuing gene and reviewed protein records identify this gene-product relation in the MG1655 reference. Experimental derivative strain scope is stated separately on regulatory edges."", ""source_locator"": ""/Entrezgene-Set/Entrezgene/Entrezgene_locus/Gene-commentary/Gene-commentary_products/Gene-commentary/Gene-commentary_source/Other-source/Other-source_src/Dbtag[Dbtag_db=\""UniProtKB/Swiss-Prot\""]/Dbtag_tag/Object-id/Object-id_str; Entrezgene_gene/Gene-ref/Gene-ref_locus""}, {""reference_id"": ""UniProtKB:P46883"", ""source_assertion"": ""The reviewed entry includes this GeneID association."", ""source_locator"": ""uniProtKBCrossReferences[GeneID]""}]"	"[{""id"": ""Entrez:945939"", ""source_sha256"": ""d02406233f4aa2da977011476e7aec5cfaa24e32f95a5a0c934c8258e76faef3"", ""source_version"": ""Retrieved 2026-10-12; exact MG1655 gene original, native locus name"", ""title"": ""NCBI Gene 945939: tynA"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=gene&id=945939&rettype=xml""}, {""id"": ""UniProtKB:P46883"", ""source_sha256"": ""79e7e4a8836d1f449023ae51cd33dd76ef74fbf710af4b3572b4f6bbbee524f9"", ""source_version"": ""Issuing UniProt original; entryVersion 206; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Primary amine oxidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46883.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-084_b15ccacb31f5	Entrez:945941	pathwaymech:enables	UniProtKB:Q47129	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Entrez:945941|UniProtKB:Q47129	The issuing gene and reviewed protein records identify this gene-product relation in the MG1655 reference. Experimental derivative strain scope is stated separately on regulatory edges.	"[{""reference_id"": ""Entrez:945941"", ""source_assertion"": ""The issuing gene and reviewed protein records identify this gene-product relation in the MG1655 reference. Experimental derivative strain scope is stated separately on regulatory edges."", ""source_locator"": ""/Entrezgene-Set/Entrezgene/Entrezgene_locus/Gene-commentary/Gene-commentary_products/Gene-commentary/Gene-commentary_source/Other-source/Other-source_src/Dbtag[Dbtag_db=\""UniProtKB/Swiss-Prot\""]/Dbtag_tag/Object-id/Object-id_str; Entrezgene_gene/Gene-ref/Gene-ref_locus""}, {""reference_id"": ""UniProtKB:Q47129"", ""source_assertion"": ""The reviewed entry includes this GeneID association."", ""source_locator"": ""uniProtKBCrossReferences[GeneID]""}]"	"[{""id"": ""Entrez:945941"", ""source_sha256"": ""811dddd1a627041db5b82189ae0fcda0422800ce2af8c3400713ca8f483ab475"", ""source_version"": ""Retrieved 2026-10-12; exact MG1655 gene original, native locus name"", ""title"": ""NCBI Gene 945941: feaR"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=gene&id=945941&rettype=xml""}, {""id"": ""UniProtKB:Q47129"", ""source_sha256"": ""08c03accabf3884d2910efade982888bd6d072e56c285e22baf1fbad5aeb8658"", ""source_version"": ""Issuing UniProt original; entryVersion 165; sequenceVersion 1; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""Transcriptional activator FeaR"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q47129.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-085_bf9a1d9904d7	Entrez:947971	pathwaymech:enables	UniProtKB:P0AD96	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Entrez:947971|UniProtKB:P0AD96	The issuing gene and reviewed protein records identify this gene-product relation in the MG1655 reference. Experimental derivative strain scope is stated separately on regulatory edges.	"[{""reference_id"": ""Entrez:947971"", ""source_assertion"": ""The issuing gene and reviewed protein records identify this gene-product relation in the MG1655 reference. Experimental derivative strain scope is stated separately on regulatory edges."", ""source_locator"": ""/Entrezgene-Set/Entrezgene/Entrezgene_locus/Gene-commentary/Gene-commentary_products/Gene-commentary/Gene-commentary_source/Other-source/Other-source_src/Dbtag[Dbtag_db=\""UniProtKB/Swiss-Prot\""]/Dbtag_tag/Object-id/Object-id_str; Entrezgene_gene/Gene-ref/Gene-ref_locus""}, {""reference_id"": ""UniProtKB:P0AD96"", ""source_assertion"": ""The reviewed entry includes this GeneID association."", ""source_locator"": ""uniProtKBCrossReferences[GeneID]""}]"	"[{""id"": ""Entrez:947971"", ""source_sha256"": ""780957db8dcc900a4a683ab1151a35b880903aeefd3c20ea6e4d23ef33b62276"", ""source_version"": ""Retrieved 2026-10-12; exact MG1655 gene original, native locus name"", ""title"": ""NCBI Gene 947971: livJ"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=gene&id=947971&rettype=xml""}, {""id"": ""UniProtKB:P0AD96"", ""source_sha256"": ""24f1315b58a9a15b1d214b3ab90e10cda4c2ed4f6a757d6dbc1e10f76fa22684"", ""source_version"": ""Issuing UniProt original; entryVersion 137; sequenceVersion 1; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""Leu/Ile/Val-binding protein"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AD96.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-086_7d142dbef904	Entrez:947961	pathwaymech:enables	UniProtKB:P22731	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Entrez:947961|UniProtKB:P22731	The issuing gene and reviewed protein records identify this gene-product relation in the MG1655 reference. Experimental derivative strain scope is stated separately on regulatory edges.	"[{""reference_id"": ""Entrez:947961"", ""source_assertion"": ""The issuing gene and reviewed protein records identify this gene-product relation in the MG1655 reference. Experimental derivative strain scope is stated separately on regulatory edges."", ""source_locator"": ""/Entrezgene-Set/Entrezgene/Entrezgene_locus/Gene-commentary/Gene-commentary_products/Gene-commentary/Gene-commentary_source/Other-source/Other-source_src/Dbtag[Dbtag_db=\""UniProtKB/Swiss-Prot\""]/Dbtag_tag/Object-id/Object-id_str; Entrezgene_gene/Gene-ref/Gene-ref_locus""}, {""reference_id"": ""UniProtKB:P22731"", ""source_assertion"": ""The reviewed entry includes this GeneID association."", ""source_locator"": ""uniProtKBCrossReferences[GeneID]""}]"	"[{""id"": ""Entrez:947961"", ""source_sha256"": ""7edfee24038440a7775ccc70bdcd0770776d35b37f3872955a95a343d08a9cd0"", ""source_version"": ""Retrieved 2026-10-12; exact MG1655 gene original, native locus name"", ""title"": ""NCBI Gene 947961: livF"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=gene&id=947961&rettype=xml""}, {""id"": ""UniProtKB:P22731"", ""source_sha256"": ""9cd48346af8c9e35e0dbb12d47ec0ed5aec026dee564c8d2b10a9a608ee5e27f"", ""source_version"": ""Issuing UniProt original; entryVersion 177; sequenceVersion 2; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""High-affinity branched-chain amino acid transport ATP-binding protein LivF"", ""url"": ""https://rest.uniprot.org/uniprotkb/P22731.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-087_d2e738b60316	Entrez:947967	pathwaymech:enables	UniProtKB:P0A9S7	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Entrez:947967|UniProtKB:P0A9S7	The issuing gene and reviewed protein records identify this gene-product relation in the MG1655 reference. Experimental derivative strain scope is stated separately on regulatory edges.	"[{""reference_id"": ""Entrez:947967"", ""source_assertion"": ""The issuing gene and reviewed protein records identify this gene-product relation in the MG1655 reference. Experimental derivative strain scope is stated separately on regulatory edges."", ""source_locator"": ""/Entrezgene-Set/Entrezgene/Entrezgene_locus/Gene-commentary/Gene-commentary_products/Gene-commentary/Gene-commentary_source/Other-source/Other-source_src/Dbtag[Dbtag_db=\""UniProtKB/Swiss-Prot\""]/Dbtag_tag/Object-id/Object-id_str; Entrezgene_gene/Gene-ref/Gene-ref_locus""}, {""reference_id"": ""UniProtKB:P0A9S7"", ""source_assertion"": ""The reviewed entry includes this GeneID association."", ""source_locator"": ""uniProtKBCrossReferences[GeneID]""}]"	"[{""id"": ""Entrez:947967"", ""source_sha256"": ""c5ffa3897ba07cf16199e50adca94cc5f195ab2d0066ccf0243f53fc9f90a289"", ""source_version"": ""Retrieved 2026-10-12; exact MG1655 gene original, native locus name"", ""title"": ""NCBI Gene 947967: livG"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=gene&id=947967&rettype=xml""}, {""id"": ""UniProtKB:P0A9S7"", ""source_sha256"": ""ee375afb207d58e08affa88e4b8dca260c576ec6afe59370392e1e84cd05e65b"", ""source_version"": ""Issuing UniProt original; entryVersion 130; sequenceVersion 1; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""High-affinity branched-chain amino acid transport ATP-binding protein LivG"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9S7.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-088_3de53c93d3c2	Entrez:947965	pathwaymech:enables	UniProtKB:P0AEX7	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Entrez:947965|UniProtKB:P0AEX7	The issuing gene and reviewed protein records identify this gene-product relation in the MG1655 reference. Experimental derivative strain scope is stated separately on regulatory edges.	"[{""reference_id"": ""Entrez:947965"", ""source_assertion"": ""The issuing gene and reviewed protein records identify this gene-product relation in the MG1655 reference. Experimental derivative strain scope is stated separately on regulatory edges."", ""source_locator"": ""/Entrezgene-Set/Entrezgene/Entrezgene_locus/Gene-commentary/Gene-commentary_products/Gene-commentary/Gene-commentary_source/Other-source/Other-source_src/Dbtag[Dbtag_db=\""UniProtKB/Swiss-Prot\""]/Dbtag_tag/Object-id/Object-id_str; Entrezgene_gene/Gene-ref/Gene-ref_locus""}, {""reference_id"": ""UniProtKB:P0AEX7"", ""source_assertion"": ""The reviewed entry includes this GeneID association."", ""source_locator"": ""uniProtKBCrossReferences[GeneID]""}]"	"[{""id"": ""Entrez:947965"", ""source_sha256"": ""21b16ae2caec8db045aa34cabaf59fce067b3cafec8e23441189e692ed592046"", ""source_version"": ""Retrieved 2026-10-12; exact MG1655 gene original, native locus name"", ""title"": ""NCBI Gene 947965: livH"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=gene&id=947965&rettype=xml""}, {""id"": ""UniProtKB:P0AEX7"", ""source_sha256"": ""dadc81da20c0b5222b1d73fe844a443f9941cdbb7f127e08b2391b1ad3175127"", ""source_version"": ""Issuing UniProt original; entryVersion 131; sequenceVersion 1; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""High-affinity branched-chain amino acid transport system permease protein LivH"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AEX7.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-089_fb754d5c9b36	Entrez:947966	pathwaymech:enables	UniProtKB:P22729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Entrez:947966|UniProtKB:P22729	The issuing gene and reviewed protein records identify this gene-product relation in the MG1655 reference. Experimental derivative strain scope is stated separately on regulatory edges.	"[{""reference_id"": ""Entrez:947966"", ""source_assertion"": ""The issuing gene and reviewed protein records identify this gene-product relation in the MG1655 reference. Experimental derivative strain scope is stated separately on regulatory edges."", ""source_locator"": ""/Entrezgene-Set/Entrezgene/Entrezgene_locus/Gene-commentary/Gene-commentary_products/Gene-commentary/Gene-commentary_source/Other-source/Other-source_src/Dbtag[Dbtag_db=\""UniProtKB/Swiss-Prot\""]/Dbtag_tag/Object-id/Object-id_str; Entrezgene_gene/Gene-ref/Gene-ref_locus""}, {""reference_id"": ""UniProtKB:P22729"", ""source_assertion"": ""The reviewed entry includes this GeneID association."", ""source_locator"": ""uniProtKBCrossReferences[GeneID]""}]"	"[{""id"": ""Entrez:947966"", ""source_sha256"": ""4243199e2aea0acd70693d67b0f92601046ea57f50396c445a35dcb87ee62442"", ""source_version"": ""Retrieved 2026-10-12; exact MG1655 gene original, native locus name"", ""title"": ""NCBI Gene 947966: livM"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=gene&id=947966&rettype=xml""}, {""id"": ""UniProtKB:P22729"", ""source_sha256"": ""8579aced6306df9ae9a07c649eece8a76b0c15bb18b668d4e59173208739de22"", ""source_version"": ""Issuing UniProt original; entryVersion 161; sequenceVersion 2; annotation date 2026-09-02; whole response digest (query responses are identified in source ledger)"", ""title"": ""High-affinity branched-chain amino acid transport system permease protein LivM"", ""url"": ""https://rest.uniprot.org/uniprotkb/P22729.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-090_8ffc344047e4	UniProtKB:P0ACJ0	pathwaymech:inhibits	Entrez:948139	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:TU00225|PMID:1917830	In BW3912-derived reporters, Lrp repressed tdh expression. This primary polarity takes precedence over the native TU00225 mode+ annotation, which is retained as a source conflict. Direct tdh-promoter binding was not established by the cited ilvIH binding assay.	"[{""reference_id"": ""PMID:1917830"", ""source_assertion"": ""In BW3912-derived reporters, Lrp repressed tdh expression. This primary polarity takes precedence over the native TU00225 mode+ annotation, which is retained as a source conflict. Direct tdh-promoter binding was not established by the cited ilvIH binding assay."", ""source_locator"": ""pp. 5948–5950, Tables 2/4 and promoter analyses""}, {""reference_id"": ""EcoCyc:TU00225"", ""source_assertion"": ""The native TU lists positive Lrp/Lrp-leucine modes; this conflicts with the inspected primary repression results and is not silently adopted."", ""source_locator"": ""Transcription-Unit/component Promoter/regulates; REG0-5455 and REG0-5454 mode+""}]"	"[{""id"": ""EcoCyc:TU00225"", ""source_sha256"": ""5bd4611d495a7b87bd04eae508d2bda95082abf0dd1737e1f870a62c1e8f4171"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc TU00225: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:TU00225""}, {""id"": ""PMID:1917830"", ""source_sha256"": ""2e3f9a5e943f332fc54160e7806bb3a3c0d0252734e4a99d654673c2b9c9cc65"", ""source_version"": ""Complete PMC original HTML and separately bound scanned pages; full pp. 5944–5953 inspected including primary Tables 2/4"", ""title"": ""The tdh and serA operons of Escherichia coli: mutational analysis of the regulatory elements of leucine-responsive genes."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC208338/""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-091_d47c5c91c607	CHEBI:15603	pathwaymech:activates	Entrez:948139	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:1917830	Leucine increased tdh reporter expression in the study's Lrp-dependent context; this is transcriptional induction, not direct allosteric activation of Tdh.	"[{""reference_id"": ""PMID:1917830"", ""source_assertion"": ""Leucine increased tdh reporter expression in the study's Lrp-dependent context; this is transcriptional induction, not direct allosteric activation of Tdh."", ""source_locator"": ""Tables 2/4 and Discussion""}]"	"[{""id"": ""PMID:1917830"", ""source_sha256"": ""2e3f9a5e943f332fc54160e7806bb3a3c0d0252734e4a99d654673c2b9c9cc65"", ""source_version"": ""Complete PMC original HTML and separately bound scanned pages; full pp. 5944–5953 inspected including primary Tables 2/4"", ""title"": ""The tdh and serA operons of Escherichia coli: mutational analysis of the regulatory elements of leucine-responsive genes."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC208338/""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-092_a26b1c672e75	EcoCyc:MONOMER0-155	BFO:0000051	UniProtKB:P0ACJ0	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:MONOMER0-155|EcoCyc:PD00353	The native Lrp-leucine frame includes the Lrp protein; component multiplicity is not specified. No occupancy or oligomer size is inferred from this membership.	"[{""reference_id"": ""EcoCyc:MONOMER0-155"", ""source_assertion"": ""The native Lrp-leucine frame includes the Lrp protein; component multiplicity is not specified. No occupancy or oligomer size is inferred from this membership."", ""source_locator"": ""Protein/component[PD00353]""}, {""reference_id"": ""EcoCyc:PD00353"", ""source_assertion"": ""The exact native PD00353 protein frame has a UNIPROT unification link to P0ACJ0; this establishes the named component identity separately from the complex coefficient."", ""source_locator"": ""/ptools-xml/Protein/dblink[dblink-db=\""UNIPROT\"" and dblink-relationship=\""unification\""]/dblink-oid""}]"	"[{""id"": ""EcoCyc:MONOMER0-155"", ""source_sha256"": ""18e2da79d6a676f7bc7c45816616a0dba6bf4f1af8b2df425fa9d67ef40d4dbf"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc MONOMER0-155: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:MONOMER0-155""}, {""id"": ""EcoCyc:PD00353"", ""source_sha256"": ""c35732fc9607c245ee01f74936da5183891e05cf76669be6c7b6c38b7da401d5"", ""source_version"": ""EcoCyc 27.0 original XML; exact native protein frame and UNIPROT unification link"", ""title"": ""EcoCyc PD00353: native component identity"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:PD00353""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-093_88abd4b8baa5	EcoCyc:MONOMER0-155	BFO:0000051	CHEBI:15603	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:MONOMER0-155	The native Lrp-leucine frame includes L-leucine without a component coefficient; no binding stoichiometry is imposed.	"[{""reference_id"": ""EcoCyc:MONOMER0-155"", ""source_assertion"": ""The native Lrp-leucine frame includes L-leucine without a component coefficient; no binding stoichiometry is imposed."", ""source_locator"": ""Protein/component[Compound LEU]; no coefficient""}]"	"[{""id"": ""EcoCyc:MONOMER0-155"", ""source_sha256"": ""18e2da79d6a676f7bc7c45816616a0dba6bf4f1af8b2df425fa9d67ef40d4dbf"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc MONOMER0-155: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:MONOMER0-155""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-094_afb4703a1c88	UniProtKB:P0ACJ0	pathwaymech:inhibits	Entrez:947971	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:1729203	Primary livJ/livKHMGF reporter experiments support Lrp-dependent transcriptional repression enhanced by leucine. The named CV/EG/SH derivatives are not all MG1655; direct promoter binding was unresolved. Transport behavior under Lrp overexpression was not a simple copy of reporter polarity.	"[{""reference_id"": ""PMID:1729203"", ""source_assertion"": ""Primary livJ/livKHMGF reporter experiments support Lrp-dependent transcriptional repression enhanced by leucine. The named CV/EG/SH derivatives are not all MG1655; direct promoter binding was unresolved. Transport behavior under Lrp overexpression was not a simple copy of reporter polarity."", ""source_locator"": ""pp. 108–114, Table 1, Figures 4/6 and Discussion; livJ versus livKHMGF operon scope""}]"	"[{""id"": ""PMID:1729203"", ""source_sha256"": ""e3cd256dd74d346ae251b774ada0e3bd1dd57d0fee3ab21f72051093167faa5f"", ""source_version"": ""Complete PMC original HTML plus separately bound original page scans/OCR; main text pp. 108–114, strain table, results and discussion; reference-only p. 115 not inspected"", ""title"": ""Lrp, a leucine-responsive protein, regulates branched-chain amino acid transport genes in Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC205683/""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-095_450ecce55d1e	UniProtKB:P0ACJ0	pathwaymech:inhibits	Entrez:947961	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:1729203	Primary livJ/livKHMGF reporter experiments support Lrp-dependent transcriptional repression enhanced by leucine. The named CV/EG/SH derivatives are not all MG1655; direct promoter binding was unresolved. Transport behavior under Lrp overexpression was not a simple copy of reporter polarity.	"[{""reference_id"": ""PMID:1729203"", ""source_assertion"": ""Primary livJ/livKHMGF reporter experiments support Lrp-dependent transcriptional repression enhanced by leucine. The named CV/EG/SH derivatives are not all MG1655; direct promoter binding was unresolved. Transport behavior under Lrp overexpression was not a simple copy of reporter polarity."", ""source_locator"": ""pp. 108–114, Table 1, Figures 4/6 and Discussion; livJ versus livKHMGF operon scope""}]"	"[{""id"": ""PMID:1729203"", ""source_sha256"": ""e3cd256dd74d346ae251b774ada0e3bd1dd57d0fee3ab21f72051093167faa5f"", ""source_version"": ""Complete PMC original HTML plus separately bound original page scans/OCR; main text pp. 108–114, strain table, results and discussion; reference-only p. 115 not inspected"", ""title"": ""Lrp, a leucine-responsive protein, regulates branched-chain amino acid transport genes in Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC205683/""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-096_babcfd79b8ae	UniProtKB:P0ACJ0	pathwaymech:inhibits	Entrez:947967	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:1729203	Primary livJ/livKHMGF reporter experiments support Lrp-dependent transcriptional repression enhanced by leucine. The named CV/EG/SH derivatives are not all MG1655; direct promoter binding was unresolved. Transport behavior under Lrp overexpression was not a simple copy of reporter polarity.	"[{""reference_id"": ""PMID:1729203"", ""source_assertion"": ""Primary livJ/livKHMGF reporter experiments support Lrp-dependent transcriptional repression enhanced by leucine. The named CV/EG/SH derivatives are not all MG1655; direct promoter binding was unresolved. Transport behavior under Lrp overexpression was not a simple copy of reporter polarity."", ""source_locator"": ""pp. 108–114, Table 1, Figures 4/6 and Discussion; livJ versus livKHMGF operon scope""}]"	"[{""id"": ""PMID:1729203"", ""source_sha256"": ""e3cd256dd74d346ae251b774ada0e3bd1dd57d0fee3ab21f72051093167faa5f"", ""source_version"": ""Complete PMC original HTML plus separately bound original page scans/OCR; main text pp. 108–114, strain table, results and discussion; reference-only p. 115 not inspected"", ""title"": ""Lrp, a leucine-responsive protein, regulates branched-chain amino acid transport genes in Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC205683/""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-097_6430acfb8717	UniProtKB:P0ACJ0	pathwaymech:inhibits	Entrez:947965	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:1729203	Primary livJ/livKHMGF reporter experiments support Lrp-dependent transcriptional repression enhanced by leucine. The named CV/EG/SH derivatives are not all MG1655; direct promoter binding was unresolved. Transport behavior under Lrp overexpression was not a simple copy of reporter polarity.	"[{""reference_id"": ""PMID:1729203"", ""source_assertion"": ""Primary livJ/livKHMGF reporter experiments support Lrp-dependent transcriptional repression enhanced by leucine. The named CV/EG/SH derivatives are not all MG1655; direct promoter binding was unresolved. Transport behavior under Lrp overexpression was not a simple copy of reporter polarity."", ""source_locator"": ""pp. 108–114, Table 1, Figures 4/6 and Discussion; livJ versus livKHMGF operon scope""}]"	"[{""id"": ""PMID:1729203"", ""source_sha256"": ""e3cd256dd74d346ae251b774ada0e3bd1dd57d0fee3ab21f72051093167faa5f"", ""source_version"": ""Complete PMC original HTML plus separately bound original page scans/OCR; main text pp. 108–114, strain table, results and discussion; reference-only p. 115 not inspected"", ""title"": ""Lrp, a leucine-responsive protein, regulates branched-chain amino acid transport genes in Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC205683/""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-098_29bc38e948f2	UniProtKB:P0ACJ0	pathwaymech:inhibits	Entrez:947966	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:1729203	Primary livJ/livKHMGF reporter experiments support Lrp-dependent transcriptional repression enhanced by leucine. The named CV/EG/SH derivatives are not all MG1655; direct promoter binding was unresolved. Transport behavior under Lrp overexpression was not a simple copy of reporter polarity.	"[{""reference_id"": ""PMID:1729203"", ""source_assertion"": ""Primary livJ/livKHMGF reporter experiments support Lrp-dependent transcriptional repression enhanced by leucine. The named CV/EG/SH derivatives are not all MG1655; direct promoter binding was unresolved. Transport behavior under Lrp overexpression was not a simple copy of reporter polarity."", ""source_locator"": ""pp. 108–114, Table 1, Figures 4/6 and Discussion; livJ versus livKHMGF operon scope""}]"	"[{""id"": ""PMID:1729203"", ""source_sha256"": ""e3cd256dd74d346ae251b774ada0e3bd1dd57d0fee3ab21f72051093167faa5f"", ""source_version"": ""Complete PMC original HTML plus separately bound original page scans/OCR; main text pp. 108–114, strain table, results and discussion; reference-only p. 115 not inspected"", ""title"": ""Lrp, a leucine-responsive protein, regulates branched-chain amino acid transport genes in Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC205683/""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-099_ca55ae23e47b	UniProtKB:Q47129	pathwaymech:activates	Entrez:945939	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:24013633	MG1655 reporter and genetic experiments support FeaR-dependent tynA expression in the tested aromatic-amine carbon/nitrogen conditions. Isolated His-tagged FeaR DNA-binding-domain experiments do not establish direct ligand binding by full-length FeaR or aminoacetone induction.	"[{""reference_id"": ""PMID:24013633"", ""source_assertion"": ""MG1655 reporter and genetic experiments support FeaR-dependent tynA expression in the tested aromatic-amine carbon/nitrogen conditions. Isolated His-tagged FeaR DNA-binding-domain experiments do not establish direct ligand binding by full-length FeaR or aminoacetone induction."", ""source_locator"": ""Methods 2.1–2.4; Results 3.1–3.7; Discussion""}]"	"[{""id"": ""PMID:24013633"", ""source_sha256"": ""0533edcd01824ad3bc3e96cd6dd47ec61a2824e2d6e4fef5330a59779a37feae"", ""source_version"": ""Complete PMC primary HTML; Methods 2.1–2.4, Results 3.1–3.7 and Discussion inspected"", ""title"": ""Finely Tuned Regulation of the Aromatic Amine Degradation Pathway in Escherichia coli"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3811602/""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-100_95ebefcc53d2	EcoCyc:CPLX0-7797	pathwaymech:activates	Entrez:945939	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:AMINEOXID-CPLX|PMID:24013633	The native complex comment reports FNR-associated tynA transcriptional activation in anaerobic profiling (PMID12754220). The inspected 2013 aromatic-amine study found no anaerobic induction under its conditions; this context conflict does not establish direct promoter binding or anaerobic oxidase flux.	"[{""reference_id"": ""MetaCyc:AMINEOXID-CPLX"", ""source_assertion"": ""The native complex comment reports FNR-associated tynA transcriptional activation in anaerobic profiling (PMID12754220). The inspected 2013 aromatic-amine study found no anaerobic induction under its conditions; this context conflict does not establish direct promoter binding or anaerobic oxidase flux."", ""source_locator"": ""/ptools-xml/Protein/comment; final paragraph beginning \""Under anaerobiosis, FNR activates\"" and citing PMID12754220""}, {""reference_id"": ""PMID:24013633"", ""source_assertion"": ""No anaerobic induction was observed in the tested aromatic-amine reporter conditions."", ""source_locator"": ""Results/Discussion, oxygen dependence""}]"	"[{""id"": ""MetaCyc:AMINEOXID-CPLX"", ""source_sha256"": ""5218154a3acf80ae640e7c6b556942c0a49d702836c336de104da623c46f583e"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""MetaCyc AMINEOXID-CPLX: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:AMINEOXID-CPLX""}, {""id"": ""PMID:24013633"", ""source_sha256"": ""0533edcd01824ad3bc3e96cd6dd47ec61a2824e2d6e4fef5330a59779a37feae"", ""source_version"": ""Complete PMC primary HTML; Methods 2.1–2.4, Results 3.1–3.7 and Discussion inspected"", ""title"": ""Finely Tuned Regulation of the Aromatic Amine Degradation Pathway in Escherichia coli"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3811602/""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-101_4eb54c424586	UniProtKB:P0AF63	pathwaymech:inhibits	Entrez:945939	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:TU0-42552	The native TU reports tynA repression in the NsrR start-codon-enhanced expression context. The accessible primary abstracts do not resolve exact direct binding at tynA; the suspicious native coordinate is not reinterpreted as a validated local site.	"[{""reference_id"": ""EcoCyc:TU0-42552"", ""source_assertion"": ""The native TU reports tynA repression in the NsrR start-codon-enhanced expression context. The accessible primary abstracts do not resolve exact direct binding at tynA; the suspicious native coordinate is not reinterpreted as a validated local site."", ""source_locator"": ""Transcription-Unit/comment; PMID26239124 and PMID19656291 paragraphs""}]"	"[{""id"": ""EcoCyc:TU0-42552"", ""source_sha256"": ""106980f6268f92fd7419333021b450848ac9c2381e431c4553273946cd1ae8d4"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc TU0-42552: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:TU0-42552""}]"	"[{""description"": ""NsrR protein expressed in the cited GUG-to-AUG translation-start construct. This is a start-codon/expression-context change, not an asserted amino-acid substitution. Exact whole construct sequence and native tynA-site geometry were not established in the accessible material."", ""endpoint"": ""subject"", ""evidence"": [{""reference_id"": ""EcoCyc:TU0-42552"", ""source_assertion"": ""The native annotation specifically reports tynA repression when the nsrR start codon was changed from GUG to AUG."", ""source_locator"": ""Transcription-Unit/comment; PMID26239124 paragraph""}], ""kind"": ""experimental_construct""}]"
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-102_10d6684dbfd2	CHEBI:16828	pathwaymech:inhibits	UniProtKB:P0AGE4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9852024	Growth with 5 mM tryptophan reduced measured serine transport and sstT RNA in the reported strains/constructs. The proposed effector could be tryptophan or its metabolite; this is expression control, not direct inhibition or proof that tryptophan is transported.	"[{""reference_id"": ""PMID:9852024"", ""source_assertion"": ""Growth with 5 mM tryptophan reduced measured serine transport and sstT RNA in the reported strains/constructs. The proposed effector could be tryptophan or its metabolite; this is expression control, not direct inhibition or proof that tryptophan is transported."", ""source_locator"": ""final main-text paragraph; Northern blot and uptake observations""}]"	"[{""id"": ""PMID:9852024"", ""source_sha256"": ""3aaa726c4f609cd859447faa204666bd58772dbacb4b7ee0a2398178a515e0c8"", ""source_version"": ""Complete PMC primary HTML; all main text and figures/captions inspected; source W3133-2/WAT9 constructs carry reported Thr301"", ""title"": ""Cloning and expression of the gene for the Na+-coupled serine transporter from Escherichia coli and characteristics of the transporter"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC107783/""}]"	"[{""description"": ""W3133-2 SstT cloned into low-copy pMST3/pMST321 and assayed in WAT9, with the primary report identifying Thr301 where the current P0AGE4 reference has Ala301. Other residue identity is not assumed; this expression/uptake result is not a native MG1655 sequence assay."", ""endpoint"": ""object"", ""evidence"": [{""reference_id"": ""PMID:9852024"", ""source_assertion"": ""The source used W3133-2 DNA and WAT9 transformants; its deduced SstT sequence had Thr301 instead of the then-reference Ala301."", ""source_locator"": ""main text: cloning, sequencing and Figure 1; tryptophan-expression paragraph""}], ""kind"": ""experimental_construct""}]"
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-103_8fed4537e1cf	CHEBI:28545	pathwaymech:activates	UniProtKB:P0AGE4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12097162|UniProtKB:P0AGE4	The reviewed activity-regulation annotation assigns valinomycin activation and monensin inhibition to SstT. These effects concern the cited serine-uptake assay; unspecified monensin is not assigned to monensin A.	"[{""reference_id"": ""UniProtKB:P0AGE4"", ""source_assertion"": ""The reviewed activity-regulation annotation assigns valinomycin activation and monensin inhibition to SstT. These effects concern the cited serine-uptake assay; unspecified monensin is not assigned to monensin A."", ""source_locator"": ""comments[ACTIVITY REGULATION]; cited PMID12097162""}, {""reference_id"": ""PMID:12097162"", ""source_assertion"": ""The primary abstract describes C-terminal eight-His SstT from pTSTH, Ni-NTA purification and reconstituted proteoliposomes. Serine uptake was measured; threonine competed. The first 20 residues matched the deduced sequence after excision of initiating methionine."", ""source_locator"": ""issuing primary abstract: construction, purification, N-terminal sequencing and reconstitution""}]"	"[{""id"": ""PMID:12097162"", ""source_sha256"": ""fac670c1918bab618dd18e82c3a31b74ce5c0affe82bd81fcdcc3ac8e69110a9"", ""source_version"": ""Europe PMC issuing primary-article core abstract; retrieved 2026-10-11; no full-text claim from this body"", ""title"": ""Purification, reconstitution, and characterization of Na(+)/serine symporter, SstT, of Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12097162/""}, {""id"": ""UniProtKB:P0AGE4"", ""source_sha256"": ""7f4d92e73f3fafe6ecc404ed4558d4399a2fb8acdbf212e5c9c923d9aaba8a5e"", ""source_version"": ""Issuing UniProt original; entryVersion 132; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Serine/threonine transporter SstT"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AGE4.json""}]"	"[{""description"": ""SstT carrying eight successive C-terminal histidines, overproduced from pTSTH under the trc promoter, Ni-NTA purified and reconstituted in liposomes. The reported 20-residue N terminus lacked initiating methionine; full construct identity with current P0AGE4 or the older Thr301 variant is not assumed."", ""endpoint"": ""object"", ""evidence"": [{""reference_id"": ""PMID:12097162"", ""source_assertion"": ""The study added eight histidine codons at the sstT 3′ end, purified the fusion by Ni-NTA and reconstituted it into liposomes; only its first 20 N-terminal residues were experimentally sequenced."", ""source_locator"": ""issuing primary abstract""}], ""kind"": ""experimental_construct""}]"
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-104_05646273da6c	CHEBI:3259	pathwaymech:inhibits	UniProtKB:P0AAD8	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:2115866|UniProtKB:P0AAD8	CCCP strongly inhibited threonine uptake in the anaerobically induced MC4100/TH16-derived TdcC assays; the result supports dependence on proton motive force. Historical TdcC was reported as 431 residues, whereas current P0AAD8 is 443; the complete assayed sequence is not established. This does not identify an engineered truncation or a distinct assayed variant.	"[{""reference_id"": ""PMID:2115866"", ""source_assertion"": ""CCCP strongly inhibited threonine uptake in the anaerobically induced MC4100/TH16-derived TdcC assays; the result supports dependence on proton motive force."", ""source_locator"": ""Original article p. 4291, Characterization of transport system and energetic-inhibitor experiments""}, {""reference_id"": ""PMID:2115866"", ""source_assertion"": ""The primary Discussion describes TdcC as 431 residues; the whole-cell uptake assays are distinct from the separate PhoA/LacZ topology fusions. The complete sequence of the transport-assayed material is not established."", ""source_locator"": ""Original article p. 4291 Fig. 5 and transport experiments; p. 4292 Discussion and separate Fig. 6 fusion experiments""}, {""reference_id"": ""UniProtKB:P0AAD8"", ""source_assertion"": ""Current P0AAD8 is 443 residues and records historical sequence conflicts at residue 70 and residues 431–443. This does not prove that the historical transport preparation was a distinct physical variant."", ""source_locator"": ""sequence/length; features[type=\""Sequence conflict\""]/location and description""}]"	"[{""id"": ""PMID:2115866"", ""source_sha256"": ""e1b2f521022df82e661dd037db4bbde2560111d95fb9d86ac93617cb46ff9a4c"", ""source_version"": ""Complete PMC original HTML plus separately bound original page scans/OCR; main text pp. 4288–4293, methods, results and captions; reference-only p. 4294 not inspected"", ""title"": ""A novel membrane-associated threonine permease encoded by the tdcC gene of Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC213253/""}, {""id"": ""UniProtKB:P0AAD8"", ""source_sha256"": ""8da0289e1e40808804d0fb3106b9078c8e133ee98a47223883dd4e7a74752ff6"", ""source_version"": ""Issuing UniProt original; entryVersion 130; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Threonine/serine transporter TdcC"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AAD8.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-105_62a6c3acf65b	CHEBI:33191	pathwaymech:inhibits	UniProtKB:P0AAD8	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:2115866|UniProtKB:P0AAD8	KCN partially inhibited threonine uptake in the anaerobically induced TdcC assays. Sodium/monensin effects differed from the SstT system; this is an energetic whole-cell treatment, not a purified transporter binding assay. Historical TdcC was reported as 431 residues, whereas current P0AAD8 is 443; the complete assayed sequence is not established. This does not identify an engineered truncation or a distinct assayed variant.	"[{""reference_id"": ""PMID:2115866"", ""source_assertion"": ""KCN partially inhibited threonine uptake in the anaerobically induced TdcC assays. Sodium/monensin effects differed from the SstT system; this is an energetic whole-cell treatment, not a purified transporter binding assay."", ""source_locator"": ""Original article p. 4291, Characterization of transport system and energetic-inhibitor experiments""}, {""reference_id"": ""PMID:2115866"", ""source_assertion"": ""The primary Discussion describes TdcC as 431 residues; the whole-cell uptake assays are distinct from the separate PhoA/LacZ topology fusions. The complete sequence of the transport-assayed material is not established."", ""source_locator"": ""Original article p. 4291 Fig. 5 and transport experiments; p. 4292 Discussion and separate Fig. 6 fusion experiments""}, {""reference_id"": ""UniProtKB:P0AAD8"", ""source_assertion"": ""Current P0AAD8 is 443 residues and records historical sequence conflicts at residue 70 and residues 431–443. This does not prove that the historical transport preparation was a distinct physical variant."", ""source_locator"": ""sequence/length; features[type=\""Sequence conflict\""]/location and description""}]"	"[{""id"": ""PMID:2115866"", ""source_sha256"": ""e1b2f521022df82e661dd037db4bbde2560111d95fb9d86ac93617cb46ff9a4c"", ""source_version"": ""Complete PMC original HTML plus separately bound original page scans/OCR; main text pp. 4288–4293, methods, results and captions; reference-only p. 4294 not inspected"", ""title"": ""A novel membrane-associated threonine permease encoded by the tdcC gene of Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC213253/""}, {""id"": ""UniProtKB:P0AAD8"", ""source_sha256"": ""8da0289e1e40808804d0fb3106b9078c8e133ee98a47223883dd4e7a74752ff6"", ""source_version"": ""Issuing UniProt original; entryVersion 130; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Threonine/serine transporter TdcC"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AAD8.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-106_56dfe18fd8d1	CHEBI:17115	pathwaymech:inhibits	UniProtKB:P0AAD8	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:2115866|UniProtKB:P0AAD8	Excess L-serine strongly reduced radiolabeled threonine uptake in the TdcC-expressing cell assay; competition does not imply an allosteric inhibitor. Historical TdcC was reported as 431 residues, whereas current P0AAD8 is 443; the complete assayed sequence is not established. This does not identify an engineered truncation or a distinct assayed variant.	"[{""reference_id"": ""PMID:2115866"", ""source_assertion"": ""Excess L-serine strongly reduced radiolabeled threonine uptake in the TdcC-expressing cell assay; competition does not imply an allosteric inhibitor."", ""source_locator"": ""Original article p. 4291, Characterization of transport system and Table 1; anaerobically induced TH16(pEC61), 0.5 mM competitor (50-fold)""}, {""reference_id"": ""PMID:2115866"", ""source_assertion"": ""The primary Discussion describes TdcC as 431 residues; the whole-cell uptake assays are distinct from the separate PhoA/LacZ topology fusions. The complete sequence of the transport-assayed material is not established."", ""source_locator"": ""Original article p. 4291 Fig. 5 and transport experiments; p. 4292 Discussion and separate Fig. 6 fusion experiments""}, {""reference_id"": ""UniProtKB:P0AAD8"", ""source_assertion"": ""Current P0AAD8 is 443 residues and records historical sequence conflicts at residue 70 and residues 431–443. This does not prove that the historical transport preparation was a distinct physical variant."", ""source_locator"": ""sequence/length; features[type=\""Sequence conflict\""]/location and description""}]"	"[{""id"": ""PMID:2115866"", ""source_sha256"": ""e1b2f521022df82e661dd037db4bbde2560111d95fb9d86ac93617cb46ff9a4c"", ""source_version"": ""Complete PMC original HTML plus separately bound original page scans/OCR; main text pp. 4288–4293, methods, results and captions; reference-only p. 4294 not inspected"", ""title"": ""A novel membrane-associated threonine permease encoded by the tdcC gene of Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC213253/""}, {""id"": ""UniProtKB:P0AAD8"", ""source_sha256"": ""8da0289e1e40808804d0fb3106b9078c8e133ee98a47223883dd4e7a74752ff6"", ""source_version"": ""Issuing UniProt original; entryVersion 130; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Threonine/serine transporter TdcC"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AAD8.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-107_98e2f81a603d	CHEBI:15603	pathwaymech:inhibits	UniProtKB:P0AAD8	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:2115866|UniProtKB:P0AAD8	Excess L-leucine reduced TdcC-associated threonine uptake by about half in the cell competition assay. This differs from the transcriptional Lrp/leucine claims. Historical TdcC was reported as 431 residues, whereas current P0AAD8 is 443; the complete assayed sequence is not established. This does not identify an engineered truncation or a distinct assayed variant.	"[{""reference_id"": ""PMID:2115866"", ""source_assertion"": ""Excess L-leucine reduced TdcC-associated threonine uptake by about half in the cell competition assay. This differs from the transcriptional Lrp/leucine claims."", ""source_locator"": ""Original article p. 4291, Characterization of transport system and Table 1; anaerobically induced TH16(pEC61), 0.5 mM competitor (50-fold)""}, {""reference_id"": ""PMID:2115866"", ""source_assertion"": ""The primary Discussion describes TdcC as 431 residues; the whole-cell uptake assays are distinct from the separate PhoA/LacZ topology fusions. The complete sequence of the transport-assayed material is not established."", ""source_locator"": ""Original article p. 4291 Fig. 5 and transport experiments; p. 4292 Discussion and separate Fig. 6 fusion experiments""}, {""reference_id"": ""UniProtKB:P0AAD8"", ""source_assertion"": ""Current P0AAD8 is 443 residues and records historical sequence conflicts at residue 70 and residues 431–443. This does not prove that the historical transport preparation was a distinct physical variant."", ""source_locator"": ""sequence/length; features[type=\""Sequence conflict\""]/location and description""}]"	"[{""id"": ""PMID:2115866"", ""source_sha256"": ""e1b2f521022df82e661dd037db4bbde2560111d95fb9d86ac93617cb46ff9a4c"", ""source_version"": ""Complete PMC original HTML plus separately bound original page scans/OCR; main text pp. 4288–4293, methods, results and captions; reference-only p. 4294 not inspected"", ""title"": ""A novel membrane-associated threonine permease encoded by the tdcC gene of Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC213253/""}, {""id"": ""UniProtKB:P0AAD8"", ""source_sha256"": ""8da0289e1e40808804d0fb3106b9078c8e133ee98a47223883dd4e7a74752ff6"", ""source_version"": ""Issuing UniProt original; entryVersion 130; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Threonine/serine transporter TdcC"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AAD8.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-108_af77da56f9e3	CHEBI:15699	pathwaymech:inhibits	UniProtKB:P0AAD8	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:2115866|UniProtKB:P0AAD8	Excess homoserine reduced TdcC-associated threonine uptake in the primary competition experiment; this is whole-cell substrate competition. Historical TdcC was reported as 431 residues, whereas current P0AAD8 is 443; the complete assayed sequence is not established. This does not identify an engineered truncation or a distinct assayed variant.	"[{""reference_id"": ""PMID:2115866"", ""source_assertion"": ""Excess homoserine reduced TdcC-associated threonine uptake in the primary competition experiment; this is whole-cell substrate competition."", ""source_locator"": ""Original article p. 4291, Characterization of transport system and Table 1; anaerobically induced TH16(pEC61), 0.5 mM competitor (50-fold)""}, {""reference_id"": ""PMID:2115866"", ""source_assertion"": ""The primary Discussion describes TdcC as 431 residues; the whole-cell uptake assays are distinct from the separate PhoA/LacZ topology fusions. The complete sequence of the transport-assayed material is not established."", ""source_locator"": ""Original article p. 4291 Fig. 5 and transport experiments; p. 4292 Discussion and separate Fig. 6 fusion experiments""}, {""reference_id"": ""UniProtKB:P0AAD8"", ""source_assertion"": ""Current P0AAD8 is 443 residues and records historical sequence conflicts at residue 70 and residues 431–443. This does not prove that the historical transport preparation was a distinct physical variant."", ""source_locator"": ""sequence/length; features[type=\""Sequence conflict\""]/location and description""}]"	"[{""id"": ""PMID:2115866"", ""source_sha256"": ""e1b2f521022df82e661dd037db4bbde2560111d95fb9d86ac93617cb46ff9a4c"", ""source_version"": ""Complete PMC original HTML plus separately bound original page scans/OCR; main text pp. 4288–4293, methods, results and captions; reference-only p. 4294 not inspected"", ""title"": ""A novel membrane-associated threonine permease encoded by the tdcC gene of Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC213253/""}, {""id"": ""UniProtKB:P0AAD8"", ""source_sha256"": ""8da0289e1e40808804d0fb3106b9078c8e133ee98a47223883dd4e7a74752ff6"", ""source_version"": ""Issuing UniProt original; entryVersion 130; sequenceVersion 1; annotation date 2026-06-10; whole response digest (query responses are identified in source ledger)"", ""title"": ""Threonine/serine transporter TdcC"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AAD8.json""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-109_c8e5b7db0f59	CHEBI:747879	pathwaymech:inhibits	MetaCyc:THREODEHYD-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:2007567	Iodoacetate modification of one cysteine per Tdh subunit caused complete activity loss; the isolated peptide placed it at Cys38. The pinned ChEBI native label is misspelled iodoacetacte, while its definition/structure identify iodoacetate.	"[{""reference_id"": ""PMID:2007567"", ""source_assertion"": ""Iodoacetate modification of one cysteine per Tdh subunit caused complete activity loss; the isolated peptide placed it at Cys38. The pinned ChEBI native label is misspelled iodoacetacte, while its definition/structure identify iodoacetate."", ""source_locator"": ""issuing primary abstract: active-site cysteine modification and metal removal""}]"	"[{""id"": ""PMID:2007567"", ""source_sha256"": ""74c0972630ca6fcf4030e88b3d2110e579192862a935425a5ea16c21bd5760e2"", ""source_version"": ""Europe PMC issuing primary-article core abstract; retrieved 2026-10-11; no full-text claim from this body"", ""title"": ""L-threonine dehydrogenase from Escherichia coli. Identification of an active site cysteine residue and metal ion studies."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/2007567/""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-110_d8162905faf1	CHEBI:44975	pathwaymech:inhibits	MetaCyc:THREODEHYD-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:2007567	Removing Tdh-associated zinc with 1,10-phenanthroline correlated with declining activity and eventually yielded an unstable protein; this is a chelation experiment, not an endogenous control.	"[{""reference_id"": ""PMID:2007567"", ""source_assertion"": ""Removing Tdh-associated zinc with 1,10-phenanthroline correlated with declining activity and eventually yielded an unstable protein; this is a chelation experiment, not an endogenous control."", ""source_locator"": ""issuing primary abstract: active-site cysteine modification and metal removal""}]"	"[{""id"": ""PMID:2007567"", ""source_sha256"": ""74c0972630ca6fcf4030e88b3d2110e579192862a935425a5ea16c21bd5760e2"", ""source_version"": ""Europe PMC issuing primary-article core abstract; retrieved 2026-10-11; no full-text claim from this body"", ""title"": ""L-threonine dehydrogenase from Escherichia coli. Identification of an active site cysteine residue and metal ion studies."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/2007567/""}]"	""
pathwaymech:MetaCyc_THRDLCTCAT-PWY_thr-iii-111_2cf1730d7847	CHEBI:15379	pathwaymech:inhibits	EcoCyc:CPLX0-7797	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	EcoCyc:CPLX0-7797	The native FNR comment describes oxygen-mediated oxidation of the active [4Fe-4S] form to a [2Fe-2S] form and loss of the active dimer. This bounds the anaerobic regulatory context; it is not direct TynA inhibition.	"[{""reference_id"": ""EcoCyc:CPLX0-7797"", ""source_assertion"": ""The native FNR comment describes oxygen-mediated oxidation of the active [4Fe-4S] form to a [2Fe-2S] form and loss of the active dimer. This bounds the anaerobic regulatory context; it is not direct TynA inhibition."", ""source_locator"": ""Protein/comment: oxygen, iron-sulfur cluster and dimerization paragraph""}]"	"[{""id"": ""EcoCyc:CPLX0-7797"", ""source_sha256"": ""dbc83229f049a23bdb15689c1ae8ba13def540b5eb6434874812ee26edd01a5d"", ""source_version"": ""EcoCyc 27.0 original XML; retrieved 2026-10-11/12; exact native frame scope"", ""title"": ""EcoCyc CPLX0-7797: native definition"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=ECOLI:CPLX0-7797""}]"	"[{""description"": ""Active [4Fe-4S]-containing FNR dimer under anaerobic conditions; oxygen changes this molecular state. The native complex frame is retained without claiming that its identity fixes every experimental metal/redox state."", ""endpoint"": ""object"", ""evidence"": [{""reference_id"": ""EcoCyc:CPLX0-7797"", ""source_assertion"": ""Anaerobic [4Fe-4S] acquisition promotes the active FNR dimer; oxygen oxidizes the cluster and inactivates it."", ""source_locator"": ""Protein/comment: second paragraph""}], ""kind"": ""molecular_state""}]"
pathwaymech:MetaCyc_TRPSYN-PWY_edge-001_4f7e62750a25	CHEBI:29748	pathwaymech:consumes	RHEA:21733	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21733		"[{""reference_id"": ""RHEA:21733"", ""source_assertion"": ""Rhea lists CHEBI:29748 on the substrates side of RHEA:21733 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21733']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21733"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic anthranilate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/21733""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-002_83f06c9612c2	CHEBI:58359	pathwaymech:consumes	RHEA:21733	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21733		"[{""reference_id"": ""RHEA:21733"", ""source_assertion"": ""Rhea lists CHEBI:58359 on the substrates side of RHEA:21733 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21733']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21733"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic anthranilate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/21733""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-003_2022531109b4	RHEA:21733	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21733		"[{""reference_id"": ""RHEA:21733"", ""source_assertion"": ""Rhea lists CHEBI:15361 on the products side of RHEA:21733 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21733']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21733"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic anthranilate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/21733""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-004_2212b705d27d	RHEA:21733	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21733		"[{""reference_id"": ""RHEA:21733"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:21733 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21733']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21733"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic anthranilate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/21733""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-005_302052439c93	RHEA:21733	pathwaymech:produces	CHEBI:16567	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21733		"[{""reference_id"": ""RHEA:21733"", ""source_assertion"": ""Rhea lists CHEBI:16567 on the products side of RHEA:21733 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21733']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21733"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic anthranilate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/21733""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-006_ff03a210778f	RHEA:21733	pathwaymech:produces	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21733		"[{""reference_id"": ""RHEA:21733"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the products side of RHEA:21733 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21733']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21733"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic anthranilate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/21733""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-007_a64ee7c22fb1	CHEBI:16567	pathwaymech:consumes	RHEA:11770	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11770		"[{""reference_id"": ""RHEA:11770"", ""source_assertion"": ""Rhea lists CHEBI:16567 on the substrates side of RHEA:11770 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11770']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11770"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic anthranilate phosphoribosyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/11770""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-008_f2703a5a2bd3	CHEBI:58017	pathwaymech:consumes	RHEA:11770	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11770		"[{""reference_id"": ""RHEA:11770"", ""source_assertion"": ""Rhea lists CHEBI:58017 on the substrates side of RHEA:11770 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11770']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11770"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic anthranilate phosphoribosyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/11770""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-009_246e0b387760	RHEA:11770	pathwaymech:produces	CHEBI:18277	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11770		"[{""reference_id"": ""RHEA:11770"", ""source_assertion"": ""Rhea lists CHEBI:18277 on the products side of RHEA:11770 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11770']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11770"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic anthranilate phosphoribosyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/11770""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-010_5b02877bdc96	RHEA:11770	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11770		"[{""reference_id"": ""RHEA:11770"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:11770 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11770']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11770"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic anthranilate phosphoribosyltransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/11770""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-011_dbef369853e2	CHEBI:18277	pathwaymech:consumes	RHEA:21541	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21541		"[{""reference_id"": ""RHEA:21541"", ""source_assertion"": ""Rhea lists CHEBI:18277 on the substrates side of RHEA:21541 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21541']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21541"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosylanthranilate isomerase direction"", ""url"": ""https://www.rhea-db.org/rhea/21541""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-012_8d9398ee70ee	RHEA:21541	pathwaymech:produces	CHEBI:58613	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21541		"[{""reference_id"": ""RHEA:21541"", ""source_assertion"": ""Rhea lists CHEBI:58613 on the products side of RHEA:21541 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21541']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21541"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosylanthranilate isomerase direction"", ""url"": ""https://www.rhea-db.org/rhea/21541""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-013_a5507a6b25c8	CHEBI:15378	pathwaymech:consumes	RHEA:23477	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23477		"[{""reference_id"": ""RHEA:23477"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:23477 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23477']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23477"", ""source_version"": ""139"", ""title"": ""Rhea indole-3-glycerol-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23477""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-014_b28974182251	CHEBI:58613	pathwaymech:consumes	RHEA:23477	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23477		"[{""reference_id"": ""RHEA:23477"", ""source_assertion"": ""Rhea lists CHEBI:58613 on the substrates side of RHEA:23477 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23477']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23477"", ""source_version"": ""139"", ""title"": ""Rhea indole-3-glycerol-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23477""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-015_e61d1a4f5ff9	RHEA:23477	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23477		"[{""reference_id"": ""RHEA:23477"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:23477 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23477']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23477"", ""source_version"": ""139"", ""title"": ""Rhea indole-3-glycerol-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23477""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-016_7d768a0789f7	RHEA:23477	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23477		"[{""reference_id"": ""RHEA:23477"", ""source_assertion"": ""Rhea lists CHEBI:16526 on the products side of RHEA:23477 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23477']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23477"", ""source_version"": ""139"", ""title"": ""Rhea indole-3-glycerol-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23477""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-017_d261775c7640	RHEA:23477	pathwaymech:produces	CHEBI:58866	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23477		"[{""reference_id"": ""RHEA:23477"", ""source_assertion"": ""Rhea lists CHEBI:58866 on the products side of RHEA:23477 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23477']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23477"", ""source_version"": ""139"", ""title"": ""Rhea indole-3-glycerol-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23477""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-018_f862eb5fae3d	CHEBI:58866	pathwaymech:consumes	RHEA:14082	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14082		"[{""reference_id"": ""RHEA:14082"", ""source_assertion"": ""Rhea lists CHEBI:58866 on the substrates side of RHEA:14082 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14082']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14082"", ""source_version"": ""139"", ""title"": ""RHEA:14082 authority record"", ""url"": ""https://www.rhea-db.org/rhea/14082""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-019_b367e88a78ff	RHEA:14082	pathwaymech:produces	CHEBI:16881	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14082		"[{""reference_id"": ""RHEA:14082"", ""source_assertion"": ""Rhea lists CHEBI:16881 on the products side of RHEA:14082 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14082']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14082"", ""source_version"": ""139"", ""title"": ""RHEA:14082 authority record"", ""url"": ""https://www.rhea-db.org/rhea/14082""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-020_4202f45f802c	RHEA:14082	pathwaymech:produces	CHEBI:59776	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14082		"[{""reference_id"": ""RHEA:14082"", ""source_assertion"": ""Rhea lists CHEBI:59776 on the products side of RHEA:14082 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14082']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14082"", ""source_version"": ""139"", ""title"": ""RHEA:14082 authority record"", ""url"": ""https://www.rhea-db.org/rhea/14082""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-021_1cd2a05860c1	CHEBI:16881	pathwaymech:consumes	RHEA:26435	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26435		"[{""reference_id"": ""RHEA:26435"", ""source_assertion"": ""Rhea lists CHEBI:16881 on the substrates side of RHEA:26435 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/26435']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:26435"", ""source_version"": ""139"", ""title"": ""RHEA:26435 authority record"", ""url"": ""https://www.rhea-db.org/rhea/26435""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-022_6eec6f55f804	CHEBI:33384	pathwaymech:consumes	RHEA:26435	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26435		"[{""reference_id"": ""RHEA:26435"", ""source_assertion"": ""Rhea lists CHEBI:33384 on the substrates side of RHEA:26435 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/26435']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:26435"", ""source_version"": ""139"", ""title"": ""RHEA:26435 authority record"", ""url"": ""https://www.rhea-db.org/rhea/26435""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-023_999126da762c	RHEA:26435	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26435		"[{""reference_id"": ""RHEA:26435"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:26435 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/26435']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:26435"", ""source_version"": ""139"", ""title"": ""RHEA:26435 authority record"", ""url"": ""https://www.rhea-db.org/rhea/26435""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-024_b97f864c89b7	RHEA:26435	pathwaymech:produces	CHEBI:57912	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26435		"[{""reference_id"": ""RHEA:26435"", ""source_assertion"": ""Rhea lists CHEBI:57912 on the products side of RHEA:26435 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/26435']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:26435"", ""source_version"": ""139"", ""title"": ""RHEA:26435 authority record"", ""url"": ""https://www.rhea-db.org/rhea/26435""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-025_8de47edf7dfc	EC:4.1.3.27	pathwaymech:catalyzes	RHEA:21733	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:4886289|RHEA:21732		"[{""reference_id"": ""RHEA:21732"", ""source_assertion"": ""Rhea associates EC:4.1.3.27 with the reaction family containing RHEA:21733."", ""source_locator"": ""rh:ec""}, {""quote"": ""Anthranilate synthetase, an enzyme specified by the tryptophan operon of Escherichia coli: purification and characterization of component I."", ""reference_id"": ""PMID:4886289"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Ito et al., Journal of Bacteriology, 1969"", ""id"": ""PMID:4886289"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/4886289/""}, {""id"": ""RHEA:21732"", ""source_version"": ""139"", ""title"": ""Rhea anthranilate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/21732""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-026_6bef1756672f	EC:2.4.2.18	pathwaymech:catalyzes	RHEA:11770	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:4886290|RHEA:11768		"[{""reference_id"": ""RHEA:11768"", ""source_assertion"": ""Rhea associates EC:2.4.2.18 with the reaction family containing RHEA:11770."", ""source_locator"": ""rh:ec""}, {""quote"": ""Anthranilate synthetase, an enzyme specified by the tryptophan operon of Escherichia coli: Comparative studies on the complex and the subunits."", ""reference_id"": ""PMID:4886290"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Ito and Yanofsky, Journal of Bacteriology, 1969"", ""id"": ""PMID:4886290"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/4886290/""}, {""id"": ""RHEA:11768"", ""source_version"": ""139"", ""title"": ""Rhea anthranilate phosphoribosyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/11768""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-027_c86ebc405104	EC:5.3.1.24	pathwaymech:catalyzes	RHEA:21541	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:3298981|RHEA:21540		"[{""reference_id"": ""RHEA:21540"", ""source_assertion"": ""Rhea associates EC:5.3.1.24 with the reaction family containing RHEA:21541."", ""source_locator"": ""rh:ec""}, {""quote"": ""Phosphoribosylanthranilate isomerase-indoleglycerol-phosphate synthase from Escherichia coli."", ""reference_id"": ""PMID:3298981"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Kirschner et al., Methods in Enzymology, 1987"", ""id"": ""PMID:3298981"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/3298981/""}, {""id"": ""RHEA:21540"", ""source_version"": ""139"", ""title"": ""Rhea phosphoribosylanthranilate isomerase reaction"", ""url"": ""https://www.rhea-db.org/rhea/21540""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-028_60856a3c79c6	EC:4.1.1.48	pathwaymech:catalyzes	RHEA:23477	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:5332729|RHEA:23476		"[{""reference_id"": ""RHEA:23476"", ""source_assertion"": ""Rhea associates EC:4.1.1.48 with the reaction family containing RHEA:23477."", ""source_locator"": ""rh:ec""}, {""quote"": ""Indole-3-glycerol phosphate synthetase of Escherichia coli, an enzyme of the tryptophan operon."", ""reference_id"": ""PMID:5332729"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Creighton and Yanofsky, Journal of Biological Chemistry, 1966"", ""id"": ""PMID:5332729"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/5332729/""}, {""id"": ""RHEA:23476"", ""source_version"": ""139"", ""title"": ""Rhea indole-3-glycerol-phosphate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/23476""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-029_77ec10a5916d	EC:4.2.1.20	pathwaymech:catalyzes	RHEA:14082	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:TRPSYN-PWY|PMID:16590328		"[{""reference_id"": ""MetaCyc:TRPSYN-PWY"", ""source_assertion"": ""The native pathway assigns EC:4.2.1.20 activity to the enzymatic step represented by RHEA:14082; this is a component step when the EC definition is an overall reaction."", ""source_locator"": ""Pathway/reaction-layout; Reaction/enzymatic-reaction and component-reaction relationships""}, {""quote"": ""ON THE SEPARATION OF THE TRYPTOPHAN SYNTHETASE OF ESCHERICHIA COLI INTO TWO PROTEIN COMPONENTS."", ""reference_id"": ""PMID:16590328"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""id"": ""MetaCyc:TRPSYN-PWY"", ""source_sha256"": ""a9e129230ce0322ab45953efb7867edbe2c9286ef59afd51f554f851f9602b5f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-tryptophan biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:TRPSYN-PWY&detail=full""}, {""citation"": ""Crawford and Yanofsky, Proceedings of the National Academy of Sciences, 1958"", ""id"": ""PMID:16590328"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/16590328/""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-030_6a04e027d6c9	EC:4.2.1.20	pathwaymech:catalyzes	RHEA:26435	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:TRPSYN-PWY|PMID:16590328		"[{""reference_id"": ""MetaCyc:TRPSYN-PWY"", ""source_assertion"": ""The native pathway assigns EC:4.2.1.20 activity to the enzymatic step represented by RHEA:26435; this is a component step when the EC definition is an overall reaction."", ""source_locator"": ""Pathway/reaction-layout; Reaction/enzymatic-reaction and component-reaction relationships""}, {""quote"": ""ON THE SEPARATION OF THE TRYPTOPHAN SYNTHETASE OF ESCHERICHIA COLI INTO TWO PROTEIN COMPONENTS."", ""reference_id"": ""PMID:16590328"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""id"": ""MetaCyc:TRPSYN-PWY"", ""source_sha256"": ""a9e129230ce0322ab45953efb7867edbe2c9286ef59afd51f554f851f9602b5f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-tryptophan biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:TRPSYN-PWY&detail=full""}, {""citation"": ""Crawford and Yanofsky, Proceedings of the National Academy of Sciences, 1958"", ""id"": ""PMID:16590328"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/16590328/""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-031_deb753eb3eb1	RHEA:11770	pathwaymech:precedes	RHEA:21541	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:TRPSYN-PWY		"[{""reference_id"": ""MetaCyc:TRPSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:11770 before RHEA:21541 in this pathway. Shared intermediate: CHEBI:18277."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:TRPSYN-PWY"", ""source_sha256"": ""a9e129230ce0322ab45953efb7867edbe2c9286ef59afd51f554f851f9602b5f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-tryptophan biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:TRPSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-032_420d442ce823	RHEA:14082	pathwaymech:precedes	RHEA:26435	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:TRPSYN-PWY		"[{""reference_id"": ""MetaCyc:TRPSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:14082 before RHEA:26435 in this pathway. Shared intermediate: CHEBI:16881."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:TRPSYN-PWY"", ""source_sha256"": ""a9e129230ce0322ab45953efb7867edbe2c9286ef59afd51f554f851f9602b5f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-tryptophan biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:TRPSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-033_cb1b9cd25f66	RHEA:21541	pathwaymech:precedes	RHEA:23477	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:TRPSYN-PWY		"[{""reference_id"": ""MetaCyc:TRPSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:21541 before RHEA:23477 in this pathway. Shared intermediate: CHEBI:58613."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:TRPSYN-PWY"", ""source_sha256"": ""a9e129230ce0322ab45953efb7867edbe2c9286ef59afd51f554f851f9602b5f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-tryptophan biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:TRPSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-034_6d8b0f160046	RHEA:21733	pathwaymech:precedes	RHEA:11770	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:TRPSYN-PWY		"[{""reference_id"": ""MetaCyc:TRPSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:21733 before RHEA:11770 in this pathway. Shared intermediate: CHEBI:16567."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:TRPSYN-PWY"", ""source_sha256"": ""a9e129230ce0322ab45953efb7867edbe2c9286ef59afd51f554f851f9602b5f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-tryptophan biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:TRPSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-035_2853dc4019c8	RHEA:23477	pathwaymech:precedes	RHEA:14082	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:TRPSYN-PWY		"[{""reference_id"": ""MetaCyc:TRPSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:23477 before RHEA:14082 in this pathway. Shared intermediate: CHEBI:58866."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:TRPSYN-PWY"", ""source_sha256"": ""a9e129230ce0322ab45953efb7867edbe2c9286ef59afd51f554f851f9602b5f"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-tryptophan biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:TRPSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-036_2d5a1c322434	UniProtKB:P00895	pathwaymech:enables	RHEA:21733	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00895		"[{""reference_id"": ""UniProtKB:P00895"", ""source_assertion"": ""UniProt annotates UniProtKB:P00895 with catalytic activity for the reaction family of RHEA:21733. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00895"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00895 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00895.json""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-037_e3d7db2a3efc	CHEBI:57912	pathwaymech:inhibits	UniProtKB:P00895	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00895		"[{""reference_id"": ""UniProtKB:P00895"", ""source_assertion"": ""UniProt activity-regulation annotation: Cooperatively feedback inhibited by tryptophan"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P00895"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00895 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00895.json""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-038_c280c30e9671	UniProtKB:P00895	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00895		"[{""reference_id"": ""UniProtKB:P00895"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P00895 (evidence: ECO:0000250). Binds 1 Mg(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P00895"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00895 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00895.json""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-039_0fc8a072c8d5	UniProtKB:P00904	pathwaymech:enables	RHEA:21733	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00904		"[{""reference_id"": ""UniProtKB:P00904"", ""source_assertion"": ""UniProt annotates UniProtKB:P00904 with catalytic activity for the reaction family of RHEA:21733. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00904"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00904 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00904.json""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-040_baa083952919	UniProtKB:P00904	pathwaymech:enables	RHEA:11770	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00904		"[{""reference_id"": ""UniProtKB:P00904"", ""source_assertion"": ""UniProt annotates UniProtKB:P00904 with catalytic activity for the reaction family of RHEA:11770. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00904"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00904 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00904.json""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-041_7fff39f532ee	CHEBI:57912	pathwaymech:inhibits	UniProtKB:P00904	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00904		"[{""reference_id"": ""UniProtKB:P00904"", ""source_assertion"": ""UniProt activity-regulation annotation: Cooperatively feedback inhibited by tryptophan"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P00904"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00904 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00904.json""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-042_c6b23a9b732a	UniProtKB:P00909	pathwaymech:enables	RHEA:21541	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00909		"[{""reference_id"": ""UniProtKB:P00909"", ""source_assertion"": ""UniProt annotates UniProtKB:P00909 with catalytic activity for the reaction family of RHEA:21541. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00909"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00909 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00909.json""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-043_d5c5fe9fd079	UniProtKB:P00909	pathwaymech:enables	RHEA:23477	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00909		"[{""reference_id"": ""UniProtKB:P00909"", ""source_assertion"": ""UniProt annotates UniProtKB:P00909 with catalytic activity for the reaction family of RHEA:23477. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00909"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00909 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00909.json""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-044_20bf13a628ff	UniProtKB:P0A877	pathwaymech:enables	RHEA:14082	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A877		"[{""reference_id"": ""UniProtKB:P0A877"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A877 with catalytic activity for the overall reaction containing the native MetaCyc enzymatic component RHEA:14082. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A877"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A877 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A877.json""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-045_3da743a64243	UniProtKB:P0A877	pathwaymech:enables	RHEA:26435	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A877		"[{""reference_id"": ""UniProtKB:P0A877"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A877 with catalytic activity for the overall reaction containing the native MetaCyc enzymatic component RHEA:26435. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A877"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A877 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A877.json""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-046_e7f8022dbc03	UniProtKB:P0A879	pathwaymech:enables	RHEA:14082	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A879		"[{""reference_id"": ""UniProtKB:P0A879"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A879 with catalytic activity for the overall reaction containing the native MetaCyc enzymatic component RHEA:14082. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A879"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A879 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A879.json""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-047_8731e3dd23ca	UniProtKB:P0A879	pathwaymech:enables	RHEA:26435	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A879		"[{""reference_id"": ""UniProtKB:P0A879"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A879 with catalytic activity for the overall reaction containing the native MetaCyc enzymatic component RHEA:26435. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A879"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A879 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A879.json""}]"	""
pathwaymech:MetaCyc_TRPSYN-PWY_edge-048_8bcd124754fa	UniProtKB:P0A879	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A879		"[{""reference_id"": ""UniProtKB:P0A879"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P0A879 (evidence: curated annotation). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0A879"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A879 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A879.json""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-001_fcb1023b11bb	gomodel:YeastPathways_PWY-5651/6a4c244800001147	RO:0002234	CHEBI:15740	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5651/6a4c244800001147 RO:0002234 gomodel:YeastPathways_PWY-5651/6a4c244800001149."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/0; endpoint types: /individuals/70/type; /individuals/72/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-002_7178fe9a2c77	gomodel:YeastPathways_PWY-5651/6a4c244800001147	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5651/6a4c244800001147 RO:0002233 gomodel:YeastPathways_PWY-5651/6a4c244800001148."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/1; endpoint types: /individuals/70/type; /individuals/71/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-003_be80eba9108e	gomodel:RXN-8665	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:RXN-8665 BFO:0000066 gomodel:reaction_RXN-8665_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/2; endpoint types: /individuals/22/type; /individuals/66/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-004_68b3a308b60b	gomodel:1.13.11.6-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:1.13.11.6-RXN RO:0002234 gomodel:CHEBI_15378_1.13.11.6-RXN."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/3; endpoint types: /individuals/67/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-005_29b820000a63	gomodel:KYNURENINE-3-MONOOXYGENASE-RXN	RO:0002234	CHEBI:58125	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:KYNURENINE-3-MONOOXYGENASE-RXN RO:0002234 gomodel:CHEBI_58125_KYNURENINE-3-MONOOXYGENASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/4; endpoint types: /individuals/21/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-006_c9b2afcdedfa	gomodel:3-HYDROXY-KYNURENINASE-RXN	BFO:0000050	GO:0006569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:3-HYDROXY-KYNURENINASE-RXN BFO:0000050 gomodel:YeastPathways_PWY-5651/YeastPathways_PWY-5651."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/5; endpoint types: /individuals/68/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-007_f52e04ef0f05	gomodel:3-HYDROXY-KYNURENINASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:3-HYDROXY-KYNURENINASE-RXN BFO:0000066 gomodel:reaction_3-HYDROXY-KYNURENINASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/6; endpoint types: /individuals/68/type; /individuals/63/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-009_896b0aa217e0	gomodel:3-HYDROXY-KYNURENINASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:3-HYDROXY-KYNURENINASE-RXN RO:0002233 gomodel:CHEBI_15377_3-HYDROXY-KYNURENINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/8; endpoint types: /individuals/68/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-010_f3b149b6566d	gomodel:YeastPathways_PWY-5651/6a4c244800001147	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5651/6a4c244800001147 RO:0002234 gomodel:YeastPathways_PWY-5651/6a4c244800001150."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/9; endpoint types: /individuals/70/type; /individuals/73/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-011_1b72f76fa902	gomodel:KYNURENINE-3-MONOOXYGENASE-RXN	BFO:0000050	GO:0006569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:KYNURENINE-3-MONOOXYGENASE-RXN BFO:0000050 gomodel:YeastPathways_PWY-5651/YeastPathways_PWY-5651."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/10; endpoint types: /individuals/21/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-012_1313568fb391	SGD:S000003786	pathwaymech:enables	gomodel:1.13.11.6-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:1.13.11.6-RXN RO:0002333 gomodel:YJR025C-MONOMER_1.13.11.6-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/11; endpoint types: /individuals/67/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-013_3997c8dc8c5e	gomodel:1.13.11.6-RXN	RO:0002234	CHEBI:994	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:1.13.11.6-RXN RO:0002234 gomodel:CHEBI_994_1.13.11.6-RXN."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/12; endpoint types: /individuals/67/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-014_e7565cc002ef	gomodel:3-HYDROXY-KYNURENINASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:3-HYDROXY-KYNURENINASE-RXN RO:0002234 gomodel:CHEBI_15378_3-HYDROXY-KYNURENINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/13; endpoint types: /individuals/68/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-015_3986c3efe0e4	SGD:S000000194	pathwaymech:enables	gomodel:KYNURENINE-3-MONOOXYGENASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:KYNURENINE-3-MONOOXYGENASE-RXN RO:0002333 gomodel:YBL098W-MONOMER_KYNURENINE-3-MONOOXYGENASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/14; endpoint types: /individuals/21/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-016_2451ecbf82a8	gomodel:3-HYDROXY-KYNURENINASE-RXN	RO:0002233	CHEBI:58125	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:3-HYDROXY-KYNURENINASE-RXN RO:0002233 gomodel:CHEBI_58125_KYNURENINE-3-MONOOXYGENASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/15; endpoint types: /individuals/68/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-017_bdfaeda7d9f8	gomodel:RXN-8665	RO:0002233	CHEBI:57912	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:RXN-8665 RO:0002233 gomodel:CHEBI_57912_RXN-8665."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/16; endpoint types: /individuals/22/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-019_b9d5e5724cfd	gomodel:RXN-8665	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:RXN-8665 RO:0002233 gomodel:CHEBI_15379_RXN-8665."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/18; endpoint types: /individuals/22/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-020_3fdd45537d02	gomodel:1.13.11.6-RXN	BFO:0000050	GO:0006569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:1.13.11.6-RXN BFO:0000050 gomodel:YeastPathways_PWY-5651/YeastPathways_PWY-5651."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/19; endpoint types: /individuals/67/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-021_6d98a133f090	SGD:S000003839	pathwaymech:enables	gomodel:RXN-8665	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:RXN-8665 RO:0002333 gomodel:YJR078W-MONOMER_RXN-8665_controller."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/20; endpoint types: /individuals/22/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-022_9873296d0cc0	gomodel:KYNURENINE-3-MONOOXYGENASE-RXN	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:KYNURENINE-3-MONOOXYGENASE-RXN RO:0002233 gomodel:CHEBI_57783_KYNURENINE-3-MONOOXYGENASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/21; endpoint types: /individuals/21/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-023_d8eb401cb093	gomodel:YeastPathways_PWY-5651/6a4c244800001147	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5651/6a4c244800001147 BFO:0000066 gomodel:YeastPathways_PWY-5651/6a4c244800001153."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/22; endpoint types: /individuals/70/type; /individuals/75/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-025_2ee9f0a04366	gomodel:RXN-8665	BFO:0000050	GO:0006569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:RXN-8665 BFO:0000050 gomodel:YeastPathways_PWY-5651/YeastPathways_PWY-5651."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/24; endpoint types: /individuals/22/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-026_0d282a29e622	SGD:S000002836	pathwaymech:enables	gomodel:YeastPathways_PWY-5651/6a4c244800001147	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q04066|gomodel:YeastPathways_PWY-5651	PMID:18205391 experimentally rejects BNA3 as formylkynurenine formamidase and identifies BNA7. The independently represented BNA7 reaction is retained.	"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5651/6a4c244800001147 RO:0002333 gomodel:YeastPathways_PWY-5651/6a4c244800001152."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/25; endpoint types: /individuals/70/type; /individuals/74/type""}, {""reference_id"": ""UniProtKB:Q04066"", ""source_assertion"": ""UniProt Q04066 assigns N-formyl-L-kynurenine hydrolysis to BNA7, with experimental support from PMID:18205391."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/4112/comments/0""}]"	"[{""id"": ""UniProtKB:Q04066"", ""source_sha256"": ""9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c"", ""source_version"": ""2026_03"", ""title"": ""Reviewed UniProt Q04066: catalytic-function assertions"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-027_15a2e74745e1	gomodel:KYNURENINE-3-MONOOXYGENASE-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:KYNURENINE-3-MONOOXYGENASE-RXN RO:0002233 gomodel:CHEBI_15378_KYNURENINE-3-MONOOXYGENASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/26; endpoint types: /individuals/21/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-028_e8b445da6d2c	gomodel:1.13.11.6-RXN	RO:0002233	CHEBI:36559	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:1.13.11.6-RXN RO:0002233 gomodel:CHEBI_36559_3-HYDROXY-KYNURENINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/27; endpoint types: /individuals/67/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-030_42ee01044234	gomodel:KYNURENINE-3-MONOOXYGENASE-RXN	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:KYNURENINE-3-MONOOXYGENASE-RXN RO:0002233 gomodel:CHEBI_15379_KYNURENINE-3-MONOOXYGENASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/29; endpoint types: /individuals/21/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-031_1466f27792f0	gomodel:3-HYDROXY-KYNURENINASE-RXN	RO:0002234	CHEBI:36559	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:3-HYDROXY-KYNURENINASE-RXN RO:0002234 gomodel:CHEBI_36559_3-HYDROXY-KYNURENINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/30; endpoint types: /individuals/68/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-035_8d2c1b661dc3	gomodel:KYNURENINE-3-MONOOXYGENASE-RXN	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:KYNURENINE-3-MONOOXYGENASE-RXN RO:0002234 gomodel:CHEBI_58349_KYNURENINE-3-MONOOXYGENASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/34; endpoint types: /individuals/21/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-036_04390e02db77	gomodel:YeastPathways_PWY-5651/6a4c244800001147	RO:0002233	CHEBI:58629	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5651/6a4c244800001147 RO:0002233 gomodel:CHEBI_58629_RXN-8665."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/35; endpoint types: /individuals/70/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-037_e94f9fde4abe	SGD:S000004221	pathwaymech:enables	gomodel:3-HYDROXY-KYNURENINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:3-HYDROXY-KYNURENINASE-RXN RO:0002333 gomodel:YLR231C-MONOMER_3-HYDROXY-KYNURENINASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/36; endpoint types: /individuals/68/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-038_e999f929f6ad	gomodel:KYNURENINE-3-MONOOXYGENASE-RXN	RO:0002233	CHEBI:57959	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:KYNURENINE-3-MONOOXYGENASE-RXN RO:0002233 gomodel:CHEBI_57959_ARYLFORMAMIDASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/37; endpoint types: /individuals/21/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-041_057b423b8543	gomodel:1.13.11.6-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:1.13.11.6-RXN BFO:0000066 gomodel:reaction_1.13.11.6-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/40; endpoint types: /individuals/67/type; /individuals/62/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-042_226924aca25f	gomodel:3-HYDROXY-KYNURENINASE-RXN	RO:0002234	CHEBI:57972	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:3-HYDROXY-KYNURENINASE-RXN RO:0002234 gomodel:CHEBI_57972_3-HYDROXY-KYNURENINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/41; endpoint types: /individuals/68/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-043_3a25670f05a3	gomodel:1.13.11.6-RXN	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:1.13.11.6-RXN RO:0002233 gomodel:CHEBI_15379_1.13.11.6-RXN."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/42; endpoint types: /individuals/67/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-044_8e114232688f	gomodel:KYNURENINE-3-MONOOXYGENASE-RXN	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:KYNURENINE-3-MONOOXYGENASE-RXN RO:0002234 gomodel:CHEBI_15377_KYNURENINE-3-MONOOXYGENASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/43; endpoint types: /individuals/21/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-045_181e8c849f37	gomodel:YeastPathways_PWY-5651/6a4c244800001147	BFO:0000050	GO:0006569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5651/6a4c244800001147 BFO:0000050 gomodel:YeastPathways_PWY-5651/YeastPathways_PWY-5651."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/44; endpoint types: /individuals/70/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-046_4ca4d4ec75bf	gomodel:RXN-8665	RO:0002234	CHEBI:58629	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:RXN-8665 RO:0002234 gomodel:CHEBI_58629_RXN-8665."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/45; endpoint types: /individuals/22/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_edge-047_4f5642a40833	gomodel:YeastPathways_PWY-5651/6a4c244800001147	RO:0002234	CHEBI:57959	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5651		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5651"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5651/6a4c244800001147 RO:0002234 gomodel:CHEBI_57959_ARYLFORMAMIDASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5651.json#/facts/46; endpoint types: /individuals/70/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5651"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY-5651.json"", ""title"": ""GO-CAM L-tryptophan degradation model YeastPathways_PWY-5651"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_location-48cbb8390a67_d9a6448e9bed	SGD:S000003786	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47096	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03019); ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P47096"", ""source_assertion"": ""UniProtKB:P47096 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1960/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P47096"", ""source_assertion"": ""UniProtKB:P47096 has the exact SGD cross-reference SGD:S000003786."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1960/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P47096"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47096 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_location-272322ebd032_b0f1c31b7fe0	SGD:S000003786	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47096	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P47096"", ""source_assertion"": ""UniProtKB:P47096 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1960/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P47096"", ""source_assertion"": ""UniProtKB:P47096 has the exact SGD cross-reference SGD:S000003786."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1960/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P47096"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47096 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_location-815c04a28bf2_e92baf8fd8d5	SGD:S000000194	RO:0001025	GO:0005741	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38169	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03018); ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:14576278); ECO:0000269 (PubMed:16407407)	"[{""reference_id"": ""UniProtKB:P38169"", ""source_assertion"": ""UniProtKB:P38169 annotates location Mitochondrion outer membrane (SL-0172)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1305/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38169"", ""source_assertion"": ""UniProtKB:P38169 has the exact SGD cross-reference SGD:S000000194."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1305/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38169"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38169 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_location-e46b6915d6ad_6c2718319d95	SGD:S000004221	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q05979	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03017); ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q05979"", ""source_assertion"": ""UniProtKB:Q05979 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2700/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q05979"", ""source_assertion"": ""UniProtKB:Q05979 has the exact SGD cross-reference SGD:S000004221."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2700/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q05979"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q05979 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_location-4261ed5b3e5f_a65db9f0297e	SGD:S000004221	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q05979	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q05979"", ""source_assertion"": ""UniProtKB:Q05979 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2700/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q05979"", ""source_assertion"": ""UniProtKB:Q05979 has the exact SGD cross-reference SGD:S000004221."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2700/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q05979"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q05979 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_cofactor-aad2d86e86e3_eefc320f49f5	SGD:S000003786	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47096	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P47096"", ""source_assertion"": ""UniProtKB:P47096 annotates CHEBI:29033 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1960/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P47096"", ""source_assertion"": ""UniProtKB:P47096 has the exact SGD cross-reference SGD:S000003786."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1960/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P47096"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47096 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_cofactor-cdba6ef334fc_07eaa36dab68	SGD:S000000194	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38169	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:29429898)	"[{""reference_id"": ""UniProtKB:P38169"", ""source_assertion"": ""UniProtKB:P38169 annotates CHEBI:57692 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1305/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P38169"", ""source_assertion"": ""UniProtKB:P38169 has the exact SGD cross-reference SGD:S000000194."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1305/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38169"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38169 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_cofactor-ca929e808ce7_c9c9f689d0df	SGD:S000003839	pathwaymech:has_cofactor	CHEBI:30413	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47125	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 heme group per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P47125"", ""source_assertion"": ""UniProtKB:P47125 annotates CHEBI:30413 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3878/comments/0/cofactors/0; /results/3878/comments/0/note""}, {""reference_id"": ""UniProtKB:P47125"", ""source_assertion"": ""UniProtKB:P47125 has the exact SGD cross-reference SGD:S000003839."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3878/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P47125"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P47125 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5651_cofactor-6a3f18ce590a_f82a048c0267	SGD:S000004221	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q05979	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03017)	"[{""reference_id"": ""UniProtKB:Q05979"", ""source_assertion"": ""UniProtKB:Q05979 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2700/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:Q05979"", ""source_assertion"": ""UniProtKB:Q05979 has the exact SGD cross-reference SGD:S000004221."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2700/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q05979"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q05979 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-001_3a8e445a94ad	CHEBI:29748	pathwaymech:consumes	RHEA:13898	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13898		"[{""reference_id"": ""RHEA:13898"", ""source_assertion"": ""Rhea lists CHEBI:29748 on the substrates side of RHEA:13898 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13898']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13898"", ""source_version"": ""139"", ""title"": ""Rhea prephenate-forming chorismate mutase direction"", ""url"": ""https://www.rhea-db.org/rhea/13898""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-002_2326bc7b4610	RHEA:13898	pathwaymech:produces	CHEBI:29934	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13898		"[{""reference_id"": ""RHEA:13898"", ""source_assertion"": ""Rhea lists CHEBI:29934 on the products side of RHEA:13898 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13898']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13898"", ""source_version"": ""139"", ""title"": ""Rhea prephenate-forming chorismate mutase direction"", ""url"": ""https://www.rhea-db.org/rhea/13898""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-003_d6d277600f8b	CHEBI:29934	pathwaymech:consumes	RHEA:13870	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13870		"[{""reference_id"": ""RHEA:13870"", ""source_assertion"": ""Rhea lists CHEBI:29934 on the substrates side of RHEA:13870 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13870']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13870"", ""source_version"": ""139"", ""title"": ""Rhea 4-hydroxyphenylpyruvate-forming prephenate dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/13870""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-004_5714b0c406e5	CHEBI:57540	pathwaymech:consumes	RHEA:13870	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13870		"[{""reference_id"": ""RHEA:13870"", ""source_assertion"": ""Rhea lists CHEBI:57540 on the substrates side of RHEA:13870 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13870']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13870"", ""source_version"": ""139"", ""title"": ""Rhea 4-hydroxyphenylpyruvate-forming prephenate dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/13870""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-005_0a4757f3448e	RHEA:13870	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13870		"[{""reference_id"": ""RHEA:13870"", ""source_assertion"": ""Rhea lists CHEBI:16526 on the products side of RHEA:13870 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13870']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13870"", ""source_version"": ""139"", ""title"": ""Rhea 4-hydroxyphenylpyruvate-forming prephenate dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/13870""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-006_7b49a88b7fb8	RHEA:13870	pathwaymech:produces	CHEBI:36242	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13870		"[{""reference_id"": ""RHEA:13870"", ""source_assertion"": ""Rhea lists CHEBI:36242 on the products side of RHEA:13870 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13870']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13870"", ""source_version"": ""139"", ""title"": ""Rhea 4-hydroxyphenylpyruvate-forming prephenate dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/13870""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-007_82dceb728fd3	RHEA:13870	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13870		"[{""reference_id"": ""RHEA:13870"", ""source_assertion"": ""Rhea lists CHEBI:57945 on the products side of RHEA:13870 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13870']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13870"", ""source_version"": ""139"", ""title"": ""Rhea 4-hydroxyphenylpyruvate-forming prephenate dehydrogenase direction"", ""url"": ""https://www.rhea-db.org/rhea/13870""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-008_170299c84d4f	CHEBI:29985	pathwaymech:consumes	RHEA:15095	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15095		"[{""reference_id"": ""RHEA:15095"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the substrates side of RHEA:15095 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15095']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15095"", ""source_version"": ""139"", ""title"": ""Rhea L-tyrosine-forming aminotransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/15095""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-009_364fc6524bb3	CHEBI:36242	pathwaymech:consumes	RHEA:15095	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15095		"[{""reference_id"": ""RHEA:15095"", ""source_assertion"": ""Rhea lists CHEBI:36242 on the substrates side of RHEA:15095 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15095']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15095"", ""source_version"": ""139"", ""title"": ""Rhea L-tyrosine-forming aminotransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/15095""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-010_35724b872d4d	RHEA:15095	pathwaymech:produces	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15095		"[{""reference_id"": ""RHEA:15095"", ""source_assertion"": ""Rhea lists CHEBI:16810 on the products side of RHEA:15095 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15095']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15095"", ""source_version"": ""139"", ""title"": ""Rhea L-tyrosine-forming aminotransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/15095""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-011_403b23c2c85e	RHEA:15095	pathwaymech:produces	CHEBI:58315	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15095		"[{""reference_id"": ""RHEA:15095"", ""source_assertion"": ""Rhea lists CHEBI:58315 on the products side of RHEA:15095 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15095']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15095"", ""source_version"": ""139"", ""title"": ""Rhea L-tyrosine-forming aminotransferase direction"", ""url"": ""https://www.rhea-db.org/rhea/15095""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-012_41907d5d82b1	EC:5.4.99.5	pathwaymech:catalyzes	RHEA:13898	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12581215|RHEA:13897		"[{""reference_id"": ""RHEA:13897"", ""source_assertion"": ""Rhea associates EC:5.4.99.5 with the reaction family containing RHEA:13898."", ""source_locator"": ""rh:ec""}, {""quote"": ""Mapping of chorismate mutase and prephenate dehydrogenase domains in the Escherichia coli T-protein."", ""reference_id"": ""PMID:12581215"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Chen et al., European Journal of Biochemistry, 2003"", ""id"": ""PMID:12581215"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12581215/""}, {""id"": ""RHEA:13897"", ""source_version"": ""139"", ""title"": ""Rhea chorismate mutase reaction"", ""url"": ""https://www.rhea-db.org/rhea/13897""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-013_898b9698e086	EC:1.3.1.12	pathwaymech:catalyzes	RHEA:13870	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12581215|RHEA:13869		"[{""reference_id"": ""RHEA:13869"", ""source_assertion"": ""Rhea associates EC:1.3.1.12 with the reaction family containing RHEA:13870."", ""source_locator"": ""rh:ec""}, {""quote"": ""Mapping of chorismate mutase and prephenate dehydrogenase domains in the Escherichia coli T-protein."", ""reference_id"": ""PMID:12581215"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Chen et al., European Journal of Biochemistry, 2003"", ""id"": ""PMID:12581215"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12581215/""}, {""id"": ""RHEA:13869"", ""source_version"": ""139"", ""title"": ""Rhea prephenate dehydrogenase reaction"", ""url"": ""https://www.rhea-db.org/rhea/13869""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-014_89353cee25e5	EC:2.6.1.57	pathwaymech:catalyzes	RHEA:15095	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:236311|RHEA:15093		"[{""reference_id"": ""RHEA:15093"", ""source_assertion"": ""Rhea associates EC:2.6.1.57 with the reaction family containing RHEA:15095."", ""source_locator"": ""rh:ec""}, {""quote"": ""Multispecific aspartate and aromatic amino acid aminotransferases in Escherichia coli."", ""reference_id"": ""PMID:236311"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Mavrides and Orr, Journal of Biological Chemistry, 1975"", ""id"": ""PMID:236311"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/236311/""}, {""id"": ""RHEA:15093"", ""source_version"": ""139"", ""title"": ""Rhea L-tyrosine aminotransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/15093""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-015_8732321d709b	RHEA:13870	pathwaymech:precedes	RHEA:15095	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:TYRSYN		"[{""reference_id"": ""MetaCyc:TYRSYN"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:13870 before RHEA:15095 in this pathway. Shared intermediate: CHEBI:36242."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:TYRSYN"", ""source_sha256"": ""b8fba132c29627f1f45cd25198f29efa1ff9762aaf283ec0928d21324373e5fe"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-tyrosine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:TYRSYN&detail=full""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-016_12cfce4180a3	RHEA:13898	pathwaymech:precedes	RHEA:13870	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:TYRSYN		"[{""reference_id"": ""MetaCyc:TYRSYN"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:13898 before RHEA:13870 in this pathway. Shared intermediate: CHEBI:29934."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:TYRSYN"", ""source_sha256"": ""b8fba132c29627f1f45cd25198f29efa1ff9762aaf283ec0928d21324373e5fe"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-tyrosine biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:TYRSYN&detail=full""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-017_7cd9009054a8	UniProtKB:P07023	pathwaymech:enables	RHEA:13898	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07023		"[{""reference_id"": ""UniProtKB:P07023"", ""source_assertion"": ""UniProt annotates UniProtKB:P07023 with catalytic activity for the reaction family of RHEA:13898. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P07023"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P07023 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07023.json""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-018_5a742e71bea4	UniProtKB:P07023	pathwaymech:enables	RHEA:13870	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07023		"[{""reference_id"": ""UniProtKB:P07023"", ""source_assertion"": ""UniProt annotates UniProtKB:P07023 with catalytic activity for the reaction family of RHEA:13870. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P07023"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P07023 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07023.json""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-019_01d177a43b03	UniProtKB:P07023	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07023		"[{""reference_id"": ""UniProtKB:P07023"", ""source_assertion"": ""UniProt locates UniProtKB:P07023 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P07023"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P07023 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07023.json""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-020_1364599cb98b	UniProtKB:P0A9J8	pathwaymech:enables	RHEA:13898	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9J8		"[{""reference_id"": ""UniProtKB:P0A9J8"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A9J8 with catalytic activity for the reaction family of RHEA:13898. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A9J8"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9J8 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9J8.json""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-021_b09e7f3f7536	CHEBI:58095	pathwaymech:inhibits	UniProtKB:P0A9J8	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9J8		"[{""reference_id"": ""UniProtKB:P0A9J8"", ""source_assertion"": ""UniProt activity-regulation annotation: Both activities are inhibited by L-phenylalanine"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P0A9J8"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9J8 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9J8.json""}]"	""
pathwaymech:MetaCyc_TYRSYN_edge-022_1b089ac04722	UniProtKB:P0A9J8	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9J8		"[{""reference_id"": ""UniProtKB:P0A9J8"", ""source_assertion"": ""UniProt locates UniProtKB:P0A9J8 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A9J8"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9J8 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9J8.json""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-001_73ef19c0b710	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710	BFO:0000050	GO:0006572	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710 BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/0; endpoint types: /individuals/104/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-002_bbc1e43df20d	gomodel:RXN3O-4157	RO:0002413	gomodel:4.1.1.80-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4157 RO:0002413 gomodel:4.1.1.80-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/1; endpoint types: /individuals/16/type; /individuals/47/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-003_f51272486e94	SGD:S000003170	pathwaymech:enables	gomodel:TYROSINE-AMINOTRANSFERASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002333 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000639."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/2; endpoint types: /individuals/17/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-004_706cd91b8621	gomodel:4.1.1.80-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:4.1.1.80-RXN RO:0002233 gomodel:CHEBI_15378_4.1.1.80-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/3; endpoint types: /individuals/47/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-005_1b6941345eef	gomodel:RXN3O-4113	BFO:0000050	GO:0006572	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4113 BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/4; endpoint types: /individuals/15/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-006_d38995f8ec70	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688	RO:0002234	CHEBI:1879	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000692."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/5; endpoint types: /individuals/91/type; /individuals/95/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-007_053ec888b3b0	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000679."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/6; endpoint types: /individuals/84/type; /individuals/86/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-008_ff173a1d52e1	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000691."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/7; endpoint types: /individuals/91/type; /individuals/94/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-009_bed5c175a822	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661	RO:0002413	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/8; endpoint types: /individuals/69/type; /individuals/84/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-010_2d24e56c206c	gomodel:RXN3O-4157	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4157 BFO:0000066 gomodel:reaction_RXN3O-4157_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/9; endpoint types: /individuals/16/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-011_3c34988e6e80	SGD:S000004688	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688 RO:0002333 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000747."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/10; endpoint types: /individuals/91/type; /individuals/137/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-012_b993c7c44c7c	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644	RO:0002413	gomodel:RXN3O-4113	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002413 gomodel:RXN3O-4113."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/11; endpoint types: /individuals/54/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-013_84ad32f9967f	gomodel:TYROSINE-AMINOTRANSFERASE-RXN	RO:0002234	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_29985_TYROSINE-AMINOTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/12; endpoint types: /individuals/17/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-014_87d8044303c4	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677 BFO:0000066 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000687."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/13; endpoint types: /individuals/84/type; /individuals/90/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-015_f95b222c8ad6	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000702."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/14; endpoint types: /individuals/97/type; /individuals/100/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-016_f6db6dbedcb0	SGD:S000000349	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710 RO:0002333 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000719."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/15; endpoint types: /individuals/104/type; /individuals/109/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-017_ed2fe932fd94	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 BFO:0000066 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000666."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/16; endpoint types: /individuals/69/type; /individuals/73/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-018_08af2bc1c388	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000700."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/17; endpoint types: /individuals/97/type; /individuals/98/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-019_fafc8d7761c4	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661	RO:0002233	CHEBI:36242	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002233 gomodel:CHEBI_36242_RXN3O-4157."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/18; endpoint types: /individuals/69/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-020_029606f4c88d	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710	RO:0002234	CHEBI:1879	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000714."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/19; endpoint types: /individuals/104/type; /individuals/108/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-021_ad97b6e7d431	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000663."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/20; endpoint types: /individuals/69/type; /individuals/71/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-022_3788a6820392	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000713."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/21; endpoint types: /individuals/104/type; /individuals/107/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-023_95af34b1dde0	gomodel:4.1.1.80-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:4.1.1.80-RXN BFO:0000066 gomodel:reaction_4.1.1.80-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/22; endpoint types: /individuals/47/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-024_aefe66c868b9	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000711."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/23; endpoint types: /individuals/104/type; /individuals/105/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-025_1360d5be722c	SGD:S000004918	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677 RO:0002333 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000683."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/24; endpoint types: /individuals/84/type; /individuals/89/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-026_ac063887db9a	gomodel:RXN3O-4157	RO:0002234	CHEBI:36242	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4157 RO:0002234 gomodel:CHEBI_36242_RXN3O-4157."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/25; endpoint types: /individuals/16/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-027_2bf6597aef75	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661	RO:0002413	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/26; endpoint types: /individuals/69/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-028_cbe3337a5734	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661	RO:0002413	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/27; endpoint types: /individuals/69/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-029_e46cd339b423	gomodel:RXN3O-4113	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4113 BFO:0000066 gomodel:reaction_RXN3O-4113_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/28; endpoint types: /individuals/15/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-030_fae4edda82e3	SGD:S000001179	pathwaymech:enables	gomodel:RXN3O-4157	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4157 RO:0002333 gomodel:YHR137W-MONOMER_RXN3O-4157_controller."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/29; endpoint types: /individuals/16/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-031_fa3734c081ed	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000712."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/30; endpoint types: /individuals/104/type; /individuals/106/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-032_55d6d67c5990	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644	RO:0002233	CHEBI:36242	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002233 gomodel:CHEBI_36242_RXN3O-4157."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/31; endpoint types: /individuals/54/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-033_2735065c382b	gomodel:4.1.1.80-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:4.1.1.80-RXN RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/32; endpoint types: /individuals/47/type; /individuals/97/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-034_b04a2aafce5e	gomodel:RXN3O-4157	BFO:0000050	GO:0006572	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4157 BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/33; endpoint types: /individuals/16/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-035_77c55b188e30	gomodel:TYROSINE-AMINOTRANSFERASE-RXN	BFO:0000050	GO:0006572	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/34; endpoint types: /individuals/17/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-036_169f4946244f	gomodel:4.1.1.80-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:4.1.1.80-RXN RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/35; endpoint types: /individuals/47/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-037_bb5a277b7681	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644	RO:0002413	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/36; endpoint types: /individuals/54/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-038_38a42ac4a6a1	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710	RO:0002233	CHEBI:15621	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710 RO:0002233 gomodel:CHEBI_15621_4.1.1.80-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/37; endpoint types: /individuals/104/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-039_3e6855046ccd	gomodel:RXN3O-4113	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4113 RO:0002233 gomodel:CHEBI_15378_RXN3O-4113."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/38; endpoint types: /individuals/15/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-040_26e574619948	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677	BFO:0000050	GO:0006572	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677 BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/39; endpoint types: /individuals/84/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-041_687000825e68	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661	RO:0002413	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/40; endpoint types: /individuals/69/type; /individuals/97/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-042_5468ff07e706	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644	RO:0002413	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/41; endpoint types: /individuals/54/type; /individuals/97/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-043_741ff52dd71f	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644	RO:0002413	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/42; endpoint types: /individuals/54/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-044_16c40b8ede66	gomodel:4.1.1.80-RXN	BFO:0000050	GO:0006572	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:4.1.1.80-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/43; endpoint types: /individuals/47/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-045_08855ed82ce8	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000680."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/44; endpoint types: /individuals/84/type; /individuals/87/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-046_85c84fa36f52	gomodel:TYROSINE-AMINOTRANSFERASE-RXN	RO:0002233	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_16810_TYROSINE-AMINOTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/45; endpoint types: /individuals/17/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-047_58292fe92db8	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710 BFO:0000066 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000720."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/46; endpoint types: /individuals/104/type; /individuals/110/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-048_9cacf5c674f7	gomodel:TYROSINE-AMINOTRANSFERASE-RXN	RO:0002234	CHEBI:36242	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_36242_TYROSINE-AMINOTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/47; endpoint types: /individuals/17/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-049_08f8fb9fd338	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000689."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/48; endpoint types: /individuals/91/type; /individuals/92/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-050_494a66861ad0	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000646."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/49; endpoint types: /individuals/54/type; /individuals/56/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-051_af4b4aa6d060	gomodel:RXN3O-4113	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4113 RO:0002234 gomodel:CHEBI_57540_RXN3O-4113."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/50; endpoint types: /individuals/15/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-052_94d95a7076e2	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000645."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/51; endpoint types: /individuals/54/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-053_0cfe47f86391	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644	BFO:0000050	GO:0006572	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/52; endpoint types: /individuals/54/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-054_ea2a70aa2673	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000678."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/53; endpoint types: /individuals/84/type; /individuals/85/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-055_4b7ea41eae87	SGD:S000005446	pathwaymech:enables	gomodel:RXN3O-4113	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4113 RO:0002333 gomodel:YOL086C-MONOMER_RXN3O-4113_controller."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/54; endpoint types: /individuals/15/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-056_498b1937dc40	gomodel:4.1.1.80-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:4.1.1.80-RXN RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/55; endpoint types: /individuals/47/type; /individuals/84/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-057_907428b0af53	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699	BFO:0000050	GO:0006572	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699 BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/56; endpoint types: /individuals/97/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-058_7b90e8127b9b	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644	RO:0002234	CHEBI:15621	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002234 gomodel:CHEBI_15621_4.1.1.80-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/57; endpoint types: /individuals/54/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-059_9302cd5f72cc	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688	BFO:0000050	GO:0006572	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688 BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/58; endpoint types: /individuals/91/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-060_9015f9ff89de	SGD:S000004034	pathwaymech:enables	gomodel:4.1.1.80-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:4.1.1.80-RXN RO:0002333 gomodel:YeastPathways_PWY3O-4108/6690711d00000256."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/59; endpoint types: /individuals/47/type; /individuals/156/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-061_6fdedbf844df	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699	RO:0002233	CHEBI:15621	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699 RO:0002233 gomodel:CHEBI_15621_4.1.1.80-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/60; endpoint types: /individuals/97/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-062_c771599dfe6b	gomodel:RXN3O-4157	RO:0002233	CHEBI:58315	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4157 RO:0002233 gomodel:CHEBI_58315_RXN3O-4157."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/61; endpoint types: /individuals/16/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-063_f21beef4d12d	SGD:S000003225	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699 RO:0002333 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000706."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/62; endpoint types: /individuals/97/type; /individuals/102/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-064_9243333c9191	SGD:S000003319	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002333 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000665."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/63; endpoint types: /individuals/69/type; /individuals/72/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-065_8e0cec99b4ee	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699	RO:0002234	CHEBI:1879	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000703."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/64; endpoint types: /individuals/97/type; /individuals/101/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-066_2a11ae73a8ad	gomodel:RXN3O-4157	RO:0002234	CHEBI:57972	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4157 RO:0002234 gomodel:CHEBI_57972_RXN3O-4157."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/65; endpoint types: /individuals/16/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-067_fb19e3c5b63a	gomodel:RXN3O-4113	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4113 RO:0002233 gomodel:CHEBI_57945_RXN3O-4113."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/66; endpoint types: /individuals/15/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-068_42726d655385	gomodel:TYROSINE-AMINOTRANSFERASE-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/67; endpoint types: /individuals/17/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-069_e7cb26780157	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000701."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/68; endpoint types: /individuals/97/type; /individuals/99/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-070_32f50a7f011c	gomodel:4.1.1.80-RXN	RO:0002233	CHEBI:36242	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:4.1.1.80-RXN RO:0002233 gomodel:CHEBI_36242_RXN3O-4157."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/69; endpoint types: /individuals/47/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-071_c92e93d2031b	gomodel:TYROSINE-AMINOTRANSFERASE-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/70; endpoint types: /individuals/17/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-072_114667dab5d5	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677	RO:0002233	CHEBI:15621	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677 RO:0002233 gomodel:CHEBI_15621_4.1.1.80-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/71; endpoint types: /individuals/84/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-073_338f58e1a4fc	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000690."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/72; endpoint types: /individuals/91/type; /individuals/93/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-075_56952c868d52	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661	RO:0002413	gomodel:RXN3O-4113	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002413 gomodel:RXN3O-4113."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/74; endpoint types: /individuals/69/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-076_8635f6a53f55	gomodel:4.1.1.80-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:4.1.1.80-RXN RO:0002234 gomodel:CHEBI_16526_4.1.1.80-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/75; endpoint types: /individuals/47/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-077_bdd89ffd9081	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688	RO:0002233	CHEBI:15621	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688 RO:0002233 gomodel:CHEBI_15621_4.1.1.80-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/76; endpoint types: /individuals/91/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-078_5ffc40110b4d	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000662."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/77; endpoint types: /individuals/69/type; /individuals/70/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-079_cb9161b16d63	gomodel:4.1.1.80-RXN	RO:0002234	CHEBI:15621	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:4.1.1.80-RXN RO:0002234 gomodel:CHEBI_15621_4.1.1.80-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/78; endpoint types: /individuals/47/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-081_a70d5b6d4bb7	gomodel:RXN3O-4113	RO:0002234	CHEBI:1879	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4113 RO:0002234 gomodel:CHEBI_1879_RXN3O-4113."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/80; endpoint types: /individuals/15/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-082_c2d2d1b1f27a	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 BFO:0000066 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000650."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/81; endpoint types: /individuals/54/type; /individuals/58/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-083_cf7c0a5bd12b	gomodel:RXN3O-4113	RO:0002233	CHEBI:15621	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4113 RO:0002233 gomodel:CHEBI_15621_4.1.1.80-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/82; endpoint types: /individuals/15/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-084_f5f74b2b0441	gomodel:TYROSINE-AMINOTRANSFERASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN BFO:0000066 gomodel:reaction_TYROSINE-AMINOTRANSFERASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/83; endpoint types: /individuals/17/type; /individuals/46/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-085_7b5d88db3730	gomodel:RXN3O-4157	RO:0002233	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4157 RO:0002233 gomodel:CHEBI_15361_RXN3O-4157."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/84; endpoint types: /individuals/16/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-086_943903ac1a4b	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661	RO:0002234	CHEBI:15621	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002234 gomodel:CHEBI_15621_4.1.1.80-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/85; endpoint types: /individuals/69/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-087_dec7c9e120c5	SGD:S000004124	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002333 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000649."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/86; endpoint types: /individuals/54/type; /individuals/57/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-088_40b1a4ccafba	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644	RO:0002413	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/87; endpoint types: /individuals/54/type; /individuals/84/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-089_9926b6f922f8	gomodel:4.1.1.80-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:4.1.1.80-RXN RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/88; endpoint types: /individuals/47/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-090_fde2e6eca38c	gomodel:RXN3O-4157	RO:0002413	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4157 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/89; endpoint types: /individuals/16/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-091_ae3018d928c1	gomodel:TYROSINE-AMINOTRANSFERASE-RXN	RO:0002413	gomodel:4.1.1.80-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002413 gomodel:4.1.1.80-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/90; endpoint types: /individuals/17/type; /individuals/47/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-092_bc7dddde6225	gomodel:TYROSINE-AMINOTRANSFERASE-RXN	RO:0002233	CHEBI:58315	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_58315_TYROSINE-AMINOTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/91; endpoint types: /individuals/17/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-093_56f29ef53d7e	gomodel:RXN3O-4157	RO:0002413	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4157 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/92; endpoint types: /individuals/16/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-094_aa5b2dfdbd57	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661	BFO:0000050	GO:0006572	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/93; endpoint types: /individuals/69/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-095_fe6ddd3cc91a	gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677	RO:0002234	CHEBI:1879	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000681."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/94; endpoint types: /individuals/84/type; /individuals/88/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_edge-096_1a0140d7c1fd	gomodel:4.1.1.80-RXN	RO:0002413	gomodel:RXN3O-4113	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4108		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_assertion"": ""The model asserts gomodel:4.1.1.80-RXN RO:0002413 gomodel:RXN3O-4113."", ""source_locator"": ""./YeastPathways_PWY3O-4108.json#/facts/95; endpoint types: /individuals/47/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4108"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json"", ""title"": ""SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_location-ad4354e8d3df_243e28e9d104	SGD:S000003170	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53090	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2112/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 has the exact SGD cross-reference SGD:S000003170."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2112/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53090"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53090 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_location-36703d5e93fc_7380f1315d3b	SGD:S000004688	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07246	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:1101965); ECO:0000269 (PubMed:2188098); ECO:0000269 (PubMed:2943982)	"[{""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_location-b5d74d4cb0f4_aad765aebfc2	SGD:S000004688	RO:0001025	GO:0005743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07246	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	"[{""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 annotates location Mitochondrion inner membrane (SL-0168)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_location-07b1015cc728_27ac0c19f7f6	SGD:S000000349	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38113	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38113"", ""source_assertion"": ""UniProtKB:P38113 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3563/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38113"", ""source_assertion"": ""UniProtKB:P38113 has the exact SGD cross-reference SGD:S000000349."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3563/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38113"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38113 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_location-83d9f7cee755_27f65d09724a	SGD:S000004918	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00331	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:2937632)	"[{""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00331"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00331 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_location-21257d2833bc_21fb4bafd2f7	SGD:S000001179	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38840	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1469/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 has the exact SGD cross-reference SGD:S000001179."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1469/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38840"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38840 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_location-7f1495b92dc9_ca1768032f0a	SGD:S000005446	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00330	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	"[{""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00330"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00330 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_location-e48c97df72e4_2716edfcc8bc	SGD:S000004034	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06169	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P06169"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06169 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_location-d8ee7aa94925_d0c477b7e4b1	SGD:S000004034	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06169	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P06169"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06169 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_location-c3e54c00840d_1a3298654531	SGD:S000003225	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10127	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/302/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/302/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P10127"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P10127 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_location-ea1ab3242c76_d76793ab1f71	SGD:S000003319	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26263	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/742/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/742/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P26263"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P26263 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_location-9ea10c14185b_6bb55e7b5e39	SGD:S000004124	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16467	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P16467"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16467 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_location-19eb0ec36ddd_7e9e1f10e964	SGD:S000004124	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16467	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P16467"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16467 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_cofactor-46a0dec0bfb8_056006e40ed6	SGD:S000003170	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53090	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:23893908)	"[{""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 has the exact SGD cross-reference SGD:S000003170."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53090"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53090 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_cofactor-738cd0b35ac6_f8cee33157f4	SGD:S000004688	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07246	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	"[{""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/comments/0/cofactors/0; /results/161/comments/0/note""}, {""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P07246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_cofactor-339a304fe175_4015ff06ed85	SGD:S000000349	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38113	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	"[{""reference_id"": ""UniProtKB:P38113"", ""source_assertion"": ""UniProtKB:P38113 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3563/comments/0/cofactors/0; /results/3563/comments/0/note""}, {""reference_id"": ""UniProtKB:P38113"", ""source_assertion"": ""UniProtKB:P38113 has the exact SGD cross-reference SGD:S000000349."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3563/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38113"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38113 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_cofactor-ea44646ed080_07371d038e1f	SGD:S000004918	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00331	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	"[{""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/comments/0/cofactors/0; /results/23/comments/0/note""}, {""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00331"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00331 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_cofactor-eb2a9050a8eb_c0b0bd7eee94	SGD:S000001179	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38840	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:O84395)	"[{""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1469/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 has the exact SGD cross-reference SGD:S000001179."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1469/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38840"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38840 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_cofactor-d020d7cd99ba_e5d551a97529	SGD:S000005446	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00330	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849)	"[{""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/comments/0/cofactors/0; /results/22/comments/0/note""}, {""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00330"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00330 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_cofactor-81ce8a7e7be7_9ac145043d0e	SGD:S000004034	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06169	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10651824) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000269 (PubMed:10651824)	"[{""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/comments/0/cofactors/0; /results/127/comments/0/note""}, {""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P06169"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06169 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_cofactor-5cf6d8babbe2_e5db86544880	SGD:S000004034	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06169	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10651824) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000269 (PubMed:10651824)	"[{""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/comments/1/cofactors/0; /results/127/comments/1/note""}, {""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P06169"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06169 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_cofactor-a5e2dcd48dc5_5a79501c4efe	SGD:S000003225	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10127	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3282541) Zinc. May bind iron when zinc levels are limiting. UniProt note evidence: ECO:0000269 (PubMed:3282541)	"[{""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/comments/0/cofactors/0; /results/302/comments/0/note""}, {""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P10127"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P10127 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_cofactor-ae583f346b28_72b37485215f	SGD:S000003225	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10127	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3282541) Zinc. May bind iron when zinc levels are limiting. UniProt note evidence: ECO:0000269 (PubMed:3282541)	"[{""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 annotates CHEBI:29033 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/comments/0/cofactors/1; /results/302/comments/0/note""}, {""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P10127"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P10127 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_cofactor-437eea628a9f_2b3fabcd17b4	SGD:S000003319	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26263	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/comments/0/cofactors/0; /results/742/comments/0/note""}, {""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P26263"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P26263 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_cofactor-be7459c89012_e658967cece0	SGD:S000003319	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26263	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/comments/1/cofactors/0; /results/742/comments/1/note""}, {""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P26263"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P26263 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_cofactor-93748e431c03_839f151fe79c	SGD:S000004124	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16467	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/comments/0/cofactors/0; /results/439/comments/0/note""}, {""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P16467"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16467 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4108_cofactor-43ef6e61857d_f21b9b1f09c8	SGD:S000004124	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16467	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/comments/1/cofactors/0; /results/439/comments/1/note""}, {""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P16467"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16467 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-001_e09e0aca4d8e	CHEBI:15361	pathwaymech:consumes	RHEA:25250	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25250		"[{""reference_id"": ""RHEA:25250"", ""source_assertion"": ""Rhea lists CHEBI:15361 on the substrates side of RHEA:25250 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25250']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25250"", ""source_version"": ""139"", ""title"": ""Rhea acetolactate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/25250""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-002_bce019d35e1f	CHEBI:15378	pathwaymech:consumes	RHEA:25250	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25250		"[{""reference_id"": ""RHEA:25250"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:25250 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25250']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25250"", ""source_version"": ""139"", ""title"": ""Rhea acetolactate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/25250""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-003_3fc8b268b1e9	RHEA:25250	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25250		"[{""reference_id"": ""RHEA:25250"", ""source_assertion"": ""Rhea lists CHEBI:16526 on the products side of RHEA:25250 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25250']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25250"", ""source_version"": ""139"", ""title"": ""Rhea acetolactate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/25250""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-004_ed4a9b25545c	RHEA:25250	pathwaymech:produces	CHEBI:58476	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25250		"[{""reference_id"": ""RHEA:25250"", ""source_assertion"": ""Rhea lists CHEBI:58476 on the products side of RHEA:25250 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25250']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25250"", ""source_version"": ""139"", ""title"": ""Rhea acetolactate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/25250""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-005_aa284feb1cff	CHEBI:15378	pathwaymech:consumes	RHEA:22070	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22070		"[{""reference_id"": ""RHEA:22070"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:22070 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22070']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22070"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic acetohydroxy acid isomeroreductase direction"", ""url"": ""https://www.rhea-db.org/rhea/22070""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-006_97b63ff7480a	CHEBI:57783	pathwaymech:consumes	RHEA:22070	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22070		"[{""reference_id"": ""RHEA:22070"", ""source_assertion"": ""Rhea lists CHEBI:57783 on the substrates side of RHEA:22070 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22070']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22070"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic acetohydroxy acid isomeroreductase direction"", ""url"": ""https://www.rhea-db.org/rhea/22070""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-007_13f3c98a2352	CHEBI:58476	pathwaymech:consumes	RHEA:22070	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22070		"[{""reference_id"": ""RHEA:22070"", ""source_assertion"": ""Rhea lists CHEBI:58476 on the substrates side of RHEA:22070 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22070']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22070"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic acetohydroxy acid isomeroreductase direction"", ""url"": ""https://www.rhea-db.org/rhea/22070""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-008_ebe6d7f6a433	RHEA:22070	pathwaymech:produces	CHEBI:49072	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22070		"[{""reference_id"": ""RHEA:22070"", ""source_assertion"": ""Rhea lists CHEBI:49072 on the products side of RHEA:22070 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22070']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22070"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic acetohydroxy acid isomeroreductase direction"", ""url"": ""https://www.rhea-db.org/rhea/22070""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-009_7f9b8a4075fb	RHEA:22070	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22070		"[{""reference_id"": ""RHEA:22070"", ""source_assertion"": ""Rhea lists CHEBI:58349 on the products side of RHEA:22070 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22070']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22070"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic acetohydroxy acid isomeroreductase direction"", ""url"": ""https://www.rhea-db.org/rhea/22070""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-010_b35e8018a469	CHEBI:49072	pathwaymech:consumes	RHEA:24810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24810		"[{""reference_id"": ""RHEA:24810"", ""source_assertion"": ""Rhea lists CHEBI:49072 on the substrates side of RHEA:24810 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24810']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24810"", ""source_version"": ""139"", ""title"": ""Rhea dihydroxy-acid-to-3-methyl-2-oxobutanoate direction"", ""url"": ""https://www.rhea-db.org/rhea/24810""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-011_f02f205c112d	RHEA:24810	pathwaymech:produces	CHEBI:11851	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24810		"[{""reference_id"": ""RHEA:24810"", ""source_assertion"": ""Rhea lists CHEBI:11851 on the products side of RHEA:24810 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24810']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24810"", ""source_version"": ""139"", ""title"": ""Rhea dihydroxy-acid-to-3-methyl-2-oxobutanoate direction"", ""url"": ""https://www.rhea-db.org/rhea/24810""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-012_80094fdd30db	RHEA:24810	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24810		"[{""reference_id"": ""RHEA:24810"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:24810 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24810']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24810"", ""source_version"": ""139"", ""title"": ""Rhea dihydroxy-acid-to-3-methyl-2-oxobutanoate direction"", ""url"": ""https://www.rhea-db.org/rhea/24810""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-013_74f7edd070f3	CHEBI:11851	pathwaymech:consumes	RHEA:24815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24815		"[{""reference_id"": ""RHEA:24815"", ""source_assertion"": ""Rhea lists CHEBI:11851 on the substrates side of RHEA:24815 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24815']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24815"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic L-valine transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/24815""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-014_376489e62e0f	CHEBI:29985	pathwaymech:consumes	RHEA:24815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24815		"[{""reference_id"": ""RHEA:24815"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the substrates side of RHEA:24815 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24815']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24815"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic L-valine transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/24815""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-015_96946bbbae7a	RHEA:24815	pathwaymech:produces	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24815		"[{""reference_id"": ""RHEA:24815"", ""source_assertion"": ""Rhea lists CHEBI:16810 on the products side of RHEA:24815 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24815']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24815"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic L-valine transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/24815""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-016_2d9b3ffec4e8	RHEA:24815	pathwaymech:produces	CHEBI:57762	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24815		"[{""reference_id"": ""RHEA:24815"", ""source_assertion"": ""Rhea lists CHEBI:57762 on the products side of RHEA:24815 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24815']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24815"", ""source_version"": ""139"", ""title"": ""Rhea biosynthetic L-valine transaminase direction"", ""url"": ""https://www.rhea-db.org/rhea/24815""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-017_40fa3bba53a5	EC:2.2.1.6	pathwaymech:catalyzes	RHEA:25250	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:3301814|RHEA:25249		"[{""reference_id"": ""RHEA:25249"", ""source_assertion"": ""Rhea associates EC:2.2.1.6 with the reaction family containing RHEA:25250."", ""source_locator"": ""rh:ec""}, {""quote"": ""Physiological implications of the specificity of acetohydroxy acid synthase isozymes of enteric bacteria."", ""reference_id"": ""PMID:3301814"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Barak et al., Journal of Bacteriology, 1987"", ""id"": ""PMID:3301814"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/3301814/""}, {""id"": ""RHEA:25249"", ""source_version"": ""139"", ""title"": ""Rhea acetolactate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/25249""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-018_cd0c0a811a3f	EC:1.1.1.86	pathwaymech:catalyzes	RHEA:22070	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:27136273|RHEA:22068		"[{""reference_id"": ""RHEA:22068"", ""source_assertion"": ""Rhea associates EC:1.1.1.86 with the reaction family containing RHEA:22070."", ""source_locator"": ""rh:ec""}, {""quote"": ""Ketol-acid reductoisomerase (KARI) is a Mg(2+) -dependent enzyme in the branched-chain amino acid biosynthesis pathway."", ""reference_id"": ""PMID:27136273"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Tadrowski et al., Chemistry - A European Journal, 2016"", ""id"": ""PMID:27136273"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/27136273/""}, {""id"": ""RHEA:22068"", ""source_version"": ""139"", ""title"": ""Rhea acetohydroxy acid isomeroreductase reaction"", ""url"": ""https://www.rhea-db.org/rhea/22068""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-019_84a648b4ac91	EC:4.2.1.9	pathwaymech:catalyzes	RHEA:24810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:13727223|RHEA:24809		"[{""reference_id"": ""RHEA:24809"", ""source_assertion"": ""Rhea associates EC:4.2.1.9 with the reaction family containing RHEA:24810."", ""source_locator"": ""rh:ec""}, {""quote"": ""Dihydroxy acid dehydrase: an enzyme involved in the biosynthesis of isoleucine and valine."", ""reference_id"": ""PMID:13727223"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Myers, Journal of Biological Chemistry, 1961"", ""id"": ""PMID:13727223"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/13727223/""}, {""id"": ""RHEA:24809"", ""source_version"": ""139"", ""title"": ""Rhea dihydroxy-acid dehydratase reaction"", ""url"": ""https://www.rhea-db.org/rhea/24809""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-020_9ad424dd293a	EC:2.6.1.42	pathwaymech:catalyzes	RHEA:24815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:378964|RHEA:24813		"[{""reference_id"": ""RHEA:24813"", ""source_assertion"": ""Rhea associates EC:2.6.1.42 with the reaction family containing RHEA:24815."", ""source_locator"": ""rh:ec""}, {""quote"": ""Transaminase B from Escherichia coli: quaternary structure, amino-terminal sequence, substrate specificity, and absence of a separate valine-alpha-ketoglutarate activity."", ""reference_id"": ""PMID:378964"", ""source_locator"": ""PubMed ArticleTitle""}]"	"[{""citation"": ""Lee-Peng et al., Journal of Bacteriology, 1979"", ""id"": ""PMID:378964"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/378964/""}, {""id"": ""RHEA:24813"", ""source_version"": ""139"", ""title"": ""Rhea branched-chain-amino-acid transaminase reaction"", ""url"": ""https://www.rhea-db.org/rhea/24813""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-021_7569fbde4001	RHEA:22070	pathwaymech:precedes	RHEA:24810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:VALSYN-PWY		"[{""reference_id"": ""MetaCyc:VALSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:22070 before RHEA:24810 in this pathway. Shared intermediate: CHEBI:49072."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:VALSYN-PWY"", ""source_sha256"": ""1e61b5fb6e2924d4125717c8e5900d62191d6ad4d1c148ef75fedc4efa0d255e"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-valine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:VALSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-022_9320527a2446	RHEA:24810	pathwaymech:precedes	RHEA:24815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:VALSYN-PWY		"[{""reference_id"": ""MetaCyc:VALSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:24810 before RHEA:24815 in this pathway. Shared intermediate: CHEBI:11851."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:VALSYN-PWY"", ""source_sha256"": ""1e61b5fb6e2924d4125717c8e5900d62191d6ad4d1c148ef75fedc4efa0d255e"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-valine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:VALSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-023_10606483c914	RHEA:25250	pathwaymech:precedes	RHEA:22070	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:VALSYN-PWY		"[{""reference_id"": ""MetaCyc:VALSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:25250 before RHEA:22070 in this pathway. Shared intermediate: CHEBI:58476."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:VALSYN-PWY"", ""source_sha256"": ""1e61b5fb6e2924d4125717c8e5900d62191d6ad4d1c148ef75fedc4efa0d255e"", ""source_version"": ""22.5"", ""title"": ""MetaCyc L-valine biosynthesis pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:VALSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-024_2300b9dae713	UniProtKB:P00893	pathwaymech:enables	RHEA:25250	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00893		"[{""reference_id"": ""UniProtKB:P00893"", ""source_assertion"": ""UniProt annotates UniProtKB:P00893 with catalytic activity for the reaction family of RHEA:25250. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00893"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00893 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00893.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-025_a2b3acfd61f3	CHEBI:57762	pathwaymech:inhibits	UniProtKB:P00893	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00893		"[{""reference_id"": ""UniProtKB:P00893"", ""source_assertion"": ""UniProt activity-regulation annotation: Sensitive to valine inhibition"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P00893"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00893 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00893.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-026_c7d460ee7418	UniProtKB:P00893	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00893		"[{""reference_id"": ""UniProtKB:P00893"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P00893 (evidence: ECO:0000250). Binds 1 Mg(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P00893"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00893 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00893.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-027_3eb0e7312166	UniProtKB:P00893	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00893		"[{""reference_id"": ""UniProtKB:P00893"", ""source_assertion"": ""UniProt lists CHEBI:58937 as a cofactor of UniProtKB:P00893 (evidence: ECO:0000250). Binds 1 thiamine pyrophosphate per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P00893"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00893 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00893.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-028_c55a823187f5	UniProtKB:P00894	pathwaymech:enables	RHEA:25250	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00894		"[{""reference_id"": ""UniProtKB:P00894"", ""source_assertion"": ""UniProt annotates UniProtKB:P00894 with catalytic activity for the reaction family of RHEA:25250. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00894"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00894 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00894.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-029_2e8196cf7052	CHEBI:57762	pathwaymech:inhibits	UniProtKB:P00894	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00894		"[{""reference_id"": ""UniProtKB:P00894"", ""source_assertion"": ""UniProt activity-regulation annotation: Sensitive to valine inhibition"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P00894"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00894 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00894.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-030_ab3f217ce853	UniProtKB:P05791	pathwaymech:enables	RHEA:24810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05791		"[{""reference_id"": ""UniProtKB:P05791"", ""source_assertion"": ""UniProt annotates UniProtKB:P05791 with catalytic activity for the reaction family of RHEA:24810. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P05791"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05791 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05791.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-031_3c5ec629768d	UniProtKB:P05791	pathwaymech:has_cofactor	CHEBI:30408	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05791		"[{""reference_id"": ""UniProtKB:P05791"", ""source_assertion"": ""UniProt lists CHEBI:30408 as a cofactor of UniProtKB:P05791 (evidence: ECO:0000255). Cluster nuclearity is left unspecified: the current UniProt annotation infers [2Fe-2S], while its caution cites older E. coli [4Fe-4S] evidence and a later M. tuberculosis result."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P05791"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05791 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05791.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-032_bc1e7bc15c6d	UniProtKB:P05791	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05791		"[{""reference_id"": ""UniProtKB:P05791"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P05791 (evidence: ECO:0000255). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P05791"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05791 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05791.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-033_d05ae0cc53cb	UniProtKB:P05793	pathwaymech:enables	RHEA:22070	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05793		"[{""reference_id"": ""UniProtKB:P05793"", ""source_assertion"": ""UniProt annotates UniProtKB:P05793 with catalytic activity for the reaction family of RHEA:22070. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P05793"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05793 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05793.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-034_857fa9a74868	UniProtKB:P05793	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05793		"[{""reference_id"": ""UniProtKB:P05793"", ""source_assertion"": ""UniProt locates UniProtKB:P05793 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P05793"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05793 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05793.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-035_808cb6ef4fdd	UniProtKB:P05793	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05793		"[{""reference_id"": ""UniProtKB:P05793"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P05793 (evidence: ECO:0000255, ECO:0000269). Binds 2 magnesium ions per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P05793"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05793 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05793.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-036_3c64803e881e	UniProtKB:P08142	pathwaymech:enables	RHEA:25250	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08142		"[{""reference_id"": ""UniProtKB:P08142"", ""source_assertion"": ""UniProt annotates UniProtKB:P08142 with catalytic activity for the reaction family of RHEA:25250. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P08142"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P08142 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08142.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-037_6bd5db956b37	UniProtKB:P08142	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08142		"[{""reference_id"": ""UniProtKB:P08142"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P08142 (evidence: ECO:0000250). Binds 1 Mg(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P08142"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P08142 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08142.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-038_a8c26f6e6f02	UniProtKB:P08142	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08142		"[{""reference_id"": ""UniProtKB:P08142"", ""source_assertion"": ""UniProt lists CHEBI:58937 as a cofactor of UniProtKB:P08142 (evidence: ECO:0000250). Binds 1 thiamine pyrophosphate per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P08142"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P08142 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08142.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-039_2fb67cd8693d	UniProtKB:P0AB80	pathwaymech:enables	RHEA:24815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AB80		"[{""reference_id"": ""UniProtKB:P0AB80"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AB80 with catalytic activity for the reaction family of RHEA:24815. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AB80"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AB80 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AB80.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-040_6250cae1e5de	UniProtKB:P0AB80	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AB80		"[{""reference_id"": ""UniProtKB:P0AB80"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P0AB80 (evidence: curated annotation). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AB80"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AB80 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AB80.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-041_24f96ef1f71c	UniProtKB:P0ADF8	pathwaymech:enables	RHEA:25250	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ADF8		"[{""reference_id"": ""UniProtKB:P0ADF8"", ""source_assertion"": ""UniProt annotates UniProtKB:P0ADF8 with catalytic activity for the reaction family of RHEA:25250. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0ADF8"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0ADF8 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ADF8.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-042_caf74d8c4bde	UniProtKB:P0ADG1	pathwaymech:enables	RHEA:25250	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ADG1		"[{""reference_id"": ""UniProtKB:P0ADG1"", ""source_assertion"": ""UniProt annotates UniProtKB:P0ADG1 with catalytic activity for the reaction family of RHEA:25250. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0ADG1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0ADG1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ADG1.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-043_fec6fb0013ea	UniProtKB:P0ADG1	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ADG1		"[{""reference_id"": ""UniProtKB:P0ADG1"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P0ADG1 (evidence: ECO:0000250). Binds 1 Mg(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0ADG1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0ADG1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ADG1.json""}]"	""
pathwaymech:MetaCyc_VALSYN-PWY_edge-044_bb61fca0f92c	UniProtKB:P0ADG1	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ADG1		"[{""reference_id"": ""UniProtKB:P0ADG1"", ""source_assertion"": ""UniProt lists CHEBI:58937 as a cofactor of UniProtKB:P0ADG1 (evidence: ECO:0000250). Binds 1 thiamine pyrophosphate per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0ADG1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0ADG1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ADG1.json""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-001_77c3c01395d6	gomodel:RXN3O-4108	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4108 BFO:0000066 gomodel:reaction_RXN3O-4108_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/0; endpoint types: /individuals/10/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-002_8caa717aefcc	gomodel:YeastPathways_PWY3O-4112/6a4c244800001255	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001255 BFO:0000066 gomodel:YeastPathways_PWY3O-4112/6a4c244800001261."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/1; endpoint types: /individuals/99/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-003_ecd132fc7e38	gomodel:YeastPathways_PWY3O-4112/6a4c244800001240	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001240 BFO:0000066 gomodel:YeastPathways_PWY3O-4112/6a4c244800001247."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/2; endpoint types: /individuals/86/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-004_64187a7e265b	gomodel:YeastPathways_PWY3O-4112/6a4c244800001224	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001224 RO:0002233 gomodel:YeastPathways_PWY3O-4112/6a4c244800001225."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/3; endpoint types: /individuals/73/type; /individuals/74/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-005_11f6ee79c529	SGD:S000005446	pathwaymech:enables	gomodel:RXN3O-4109	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4109 RO:0002333 gomodel:YOL086C-MONOMER_RXN3O-4109_controller."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/4; endpoint types: /individuals/11/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-006_07b071b19154	gomodel:YeastPathways_PWY3O-4112/6a4c244800001224	BFO:0000050	GO:0006552	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001224 BFO:0000050 gomodel:YeastPathways_PWY3O-4112/YeastPathways_PWY3O-4112."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/5; endpoint types: /individuals/73/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-007_f8e36156071e	gomodel:YeastPathways_PWY3O-4112/6a4c244800001175	RO:0002233	CHEBI:57427	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001175 RO:0002233 gomodel:YeastPathways_PWY3O-4112/6a4c244800001177."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/6; endpoint types: /individuals/34/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-008_6d29acef9edb	gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN	RO:0002234	CHEBI:17865	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN RO:0002234 gomodel:CHEBI_17865_BRANCHED-CHAINAMINOTRANSFERLEU-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/7; endpoint types: /individuals/0/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-009_e3246e0f437f	gomodel:RXN3O-4109	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4109 RO:0002233 gomodel:CHEBI_57945_RXN3O-4109."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/8; endpoint types: /individuals/11/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-010_b4acd88f60fb	gomodel:YeastPathways_PWY3O-4112/6a4c244800001189	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001189 RO:0002233 gomodel:YeastPathways_PWY3O-4112/6a4c244800001190."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/9; endpoint types: /individuals/47/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-011_248fd8c21de8	gomodel:YeastPathways_PWY3O-4112/6a4c244800001240	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001240 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001243."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/10; endpoint types: /individuals/86/type; /individuals/89/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-012_f0a7c868d1e9	gomodel:YeastPathways_PWY3O-4112/6a4c244800001240	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001240 RO:0002233 gomodel:YeastPathways_PWY3O-4112/6a4c244800001241."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/11; endpoint types: /individuals/86/type; /individuals/87/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-013_424e3f6773c6	gomodel:RXN3O-4108	RO:0002233	CHEBI:17865	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4108 RO:0002233 gomodel:CHEBI_17865_BRANCHED-CHAINAMINOTRANSFERLEU-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/12; endpoint types: /individuals/10/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-014_4e573527f618	gomodel:YeastPathways_PWY3O-4112/6a4c244800001189	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001189 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001192."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/13; endpoint types: /individuals/47/type; /individuals/50/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-015_7f32f9592236	gomodel:YeastPathways_PWY3O-4112/6a4c244800001175	RO:0002234	CHEBI:17865	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001175 RO:0002234 gomodel:CHEBI_17865_BRANCHED-CHAINAMINOTRANSFERLEU-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/14; endpoint types: /individuals/34/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-016_f9f12021ba4b	gomodel:YeastPathways_PWY3O-4112/6a4c244800001255	BFO:0000050	GO:0006552	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001255 BFO:0000050 gomodel:YeastPathways_PWY3O-4112/YeastPathways_PWY3O-4112."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/15; endpoint types: /individuals/99/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-017_a83e2cf2c37f	gomodel:YeastPathways_PWY3O-4112/6a4c244800001255	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001255 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001258."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/16; endpoint types: /individuals/99/type; /individuals/102/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-018_e16f7e82b15a	gomodel:YeastPathways_PWY3O-4112/6a4c244800001255	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001255 RO:0002233 gomodel:YeastPathways_PWY3O-4112/6a4c244800001256."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/17; endpoint types: /individuals/99/type; /individuals/100/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-019_2b892614d917	gomodel:RXN3O-4108	RO:0002234	CHEBI:16638	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4108 RO:0002234 gomodel:CHEBI_16638_RXN3O-4108."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/18; endpoint types: /individuals/10/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-020_6424329dcaf9	gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN	RO:0002233	CHEBI:57427	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN RO:0002233 gomodel:CHEBI_57427_BRANCHED-CHAINAMINOTRANSFERLEU-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/19; endpoint types: /individuals/0/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-021_f82409280310	gomodel:YeastPathways_PWY3O-4112/6a4c244800001207	RO:0002234	CHEBI:15837	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001207 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001209."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/20; endpoint types: /individuals/60/type; /individuals/62/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-022_a33796345be6	SGD:S000002788	pathwaymech:enables	gomodel:RXN3O-4108	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4108 RO:0002333 gomodel:YeastPathways_PWY3O-4112/6690711d00000770."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/21; endpoint types: /individuals/10/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-023_6ab96a17d97e	gomodel:YeastPathways_PWY3O-4112/6a4c244800001207	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001207 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001210."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/22; endpoint types: /individuals/60/type; /individuals/63/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-024_3af9c1cb1fc0	gomodel:YeastPathways_PWY3O-4112/6a4c244800001224	RO:0002234	CHEBI:15837	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001224 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001226."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/23; endpoint types: /individuals/73/type; /individuals/75/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-025_1eb02e9f8034	gomodel:YeastPathways_PWY3O-4112/6a4c244800001189	RO:0002234	CHEBI:15837	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001189 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001191."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/24; endpoint types: /individuals/47/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-026_04aab7d1bdfa	gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN	BFO:0000050	GO:0006552	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4112/YeastPathways_PWY3O-4112."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/25; endpoint types: /individuals/0/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-027_e63799ca4be9	gomodel:YeastPathways_PWY3O-4112/6a4c244800001189	BFO:0000050	GO:0006552	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001189 BFO:0000050 gomodel:YeastPathways_PWY3O-4112/YeastPathways_PWY3O-4112."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/26; endpoint types: /individuals/47/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-028_f4f1236bf8f8	SGD:S000003909	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4112/6a4c244800001175	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001175 RO:0002333 gomodel:YeastPathways_PWY3O-4112/6a4c244800001179."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/27; endpoint types: /individuals/34/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-029_450f322290be	gomodel:YeastPathways_PWY3O-4112/6a4c244800001175	BFO:0000050	GO:0006552	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001175 BFO:0000050 gomodel:YeastPathways_PWY3O-4112/YeastPathways_PWY3O-4112."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/28; endpoint types: /individuals/34/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-030_57e0a60578ca	gomodel:YeastPathways_PWY3O-4112/6a4c244800001189	RO:0002233	CHEBI:16638	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001189 RO:0002233 gomodel:CHEBI_16638_RXN3O-4108."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/29; endpoint types: /individuals/47/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-031_e8e063ebd01a	gomodel:YeastPathways_PWY3O-4112/6a4c244800001175	RO:0002234	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001175 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001178."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/30; endpoint types: /individuals/34/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-032_cf53f6606fd3	gomodel:RXN3O-4108	BFO:0000050	GO:0006552	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4108 BFO:0000050 gomodel:YeastPathways_PWY3O-4112/YeastPathways_PWY3O-4112."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/31; endpoint types: /individuals/10/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-033_901f3d3c3ac2	gomodel:YeastPathways_PWY3O-4112/6a4c244800001175	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001175 BFO:0000066 gomodel:YeastPathways_PWY3O-4112/6a4c244800001181."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/32; endpoint types: /individuals/34/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-034_1af9ec93d98f	gomodel:RXN3O-4109	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4109 BFO:0000066 gomodel:reaction_RXN3O-4109_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/33; endpoint types: /individuals/11/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-035_ea65f34024b1	gomodel:YeastPathways_PWY3O-4112/6a4c244800001175	RO:0002233	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001175 RO:0002233 gomodel:YeastPathways_PWY3O-4112/6a4c244800001176."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/34; endpoint types: /individuals/34/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-036_6ecdaad9e8f4	SGD:S000002327	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4112/6a4c244800001255	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001255 RO:0002333 gomodel:YeastPathways_PWY3O-4112/6a4c244800001260."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/35; endpoint types: /individuals/99/type; /individuals/103/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-037_8419a4239b67	gomodel:RXN3O-4108	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4108 RO:0002234 gomodel:CHEBI_16526_RXN3O-4108."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/36; endpoint types: /individuals/10/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-039_0737565318e2	gomodel:YeastPathways_PWY3O-4112/6a4c244800001240	BFO:0000050	GO:0006552	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001240 BFO:0000050 gomodel:YeastPathways_PWY3O-4112/YeastPathways_PWY3O-4112."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/38; endpoint types: /individuals/86/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-040_c478221c63b2	gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN	RO:0002233	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN RO:0002233 gomodel:CHEBI_16810_BRANCHED-CHAINAMINOTRANSFERLEU-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/39; endpoint types: /individuals/0/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-041_43c347d920d5	gomodel:YeastPathways_PWY3O-4112/6a4c244800001240	RO:0002233	CHEBI:16638	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001240 RO:0002233 gomodel:CHEBI_16638_RXN3O-4108."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/40; endpoint types: /individuals/86/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-042_75b63197d447	gomodel:YeastPathways_PWY3O-4112/6a4c244800001240	RO:0002234	CHEBI:15837	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001240 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001242."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/41; endpoint types: /individuals/86/type; /individuals/88/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-043_b0739badf6b9	gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN	RO:0002234	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN RO:0002234 gomodel:CHEBI_29985_BRANCHED-CHAINAMINOTRANSFERLEU-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/42; endpoint types: /individuals/0/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-044_8e641965fa21	SGD:S000001251	pathwaymech:enables	gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN RO:0002333 gomodel:YHR208W-MONOMER_BRANCHED-CHAINAMINOTRANSFERLEU-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/43; endpoint types: /individuals/0/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-045_e02a6383bca0	SGD:S000004688	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4112/6a4c244800001207	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001207 RO:0002333 gomodel:YeastPathways_PWY3O-4112/6a4c244800001215."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/44; endpoint types: /individuals/60/type; /individuals/64/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-046_c320c65ca3eb	gomodel:RXN3O-4109	RO:0002234	CHEBI:15837	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4109 RO:0002234 gomodel:CHEBI_15837_RXN3O-4109."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/45; endpoint types: /individuals/11/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-047_6d647f6c6da4	gomodel:RXN3O-4109	BFO:0000050	GO:0006552	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4109 BFO:0000050 gomodel:YeastPathways_PWY3O-4112/YeastPathways_PWY3O-4112."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/46; endpoint types: /individuals/11/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-048_e802e470576e	gomodel:YeastPathways_PWY3O-4112/6a4c244800001207	BFO:0000050	GO:0006552	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001207 BFO:0000050 gomodel:YeastPathways_PWY3O-4112/YeastPathways_PWY3O-4112."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/47; endpoint types: /individuals/60/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-049_4d7e9e0e0f5d	gomodel:YeastPathways_PWY3O-4112/6a4c244800001255	RO:0002234	CHEBI:15837	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001255 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001257."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/48; endpoint types: /individuals/99/type; /individuals/101/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-050_5611291038a5	gomodel:RXN3O-4109	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4109 RO:0002234 gomodel:CHEBI_57540_RXN3O-4109."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/49; endpoint types: /individuals/11/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-051_6e7d1a289520	gomodel:YeastPathways_PWY3O-4112/6a4c244800001255	RO:0002233	CHEBI:16638	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001255 RO:0002233 gomodel:CHEBI_16638_RXN3O-4108."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/50; endpoint types: /individuals/99/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-052_eae90720ada2	gomodel:YeastPathways_PWY3O-4112/6a4c244800001207	RO:0002233	CHEBI:16638	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001207 RO:0002233 gomodel:CHEBI_16638_RXN3O-4108."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/51; endpoint types: /individuals/60/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-053_87bfb0b9725c	gomodel:YeastPathways_PWY3O-4112/6a4c244800001189	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001189 BFO:0000066 gomodel:YeastPathways_PWY3O-4112/6a4c244800001199."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/52; endpoint types: /individuals/47/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-054_c4447fd371de	SGD:S000003225	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4112/6a4c244800001224	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001224 RO:0002333 gomodel:YeastPathways_PWY3O-4112/6a4c244800001231."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/53; endpoint types: /individuals/73/type; /individuals/77/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-055_f329a6132e26	gomodel:YeastPathways_PWY3O-4112/6a4c244800001224	RO:0002233	CHEBI:16638	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001224 RO:0002233 gomodel:CHEBI_16638_RXN3O-4108."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/54; endpoint types: /individuals/73/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-056_c5da1139ad7b	SGD:S000000349	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4112/6a4c244800001240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001240 RO:0002333 gomodel:YeastPathways_PWY3O-4112/6a4c244800001245."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/55; endpoint types: /individuals/86/type; /individuals/90/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-058_cf6bb2d85b89	gomodel:YeastPathways_PWY3O-4112/6a4c244800001207	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001207 RO:0002233 gomodel:YeastPathways_PWY3O-4112/6a4c244800001208."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/57; endpoint types: /individuals/60/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-060_9161dfc52e5b	gomodel:RXN3O-4109	RO:0002233	CHEBI:16638	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4109 RO:0002233 gomodel:CHEBI_16638_RXN3O-4108."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/59; endpoint types: /individuals/11/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-061_b75c31f54967	SGD:S000004918	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4112/6a4c244800001189	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001189 RO:0002333 gomodel:YeastPathways_PWY3O-4112/6a4c244800001198."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/60; endpoint types: /individuals/47/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_edge-062_2b40dd07f409	gomodel:YeastPathways_PWY3O-4112/6a4c244800001224	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4112		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001224 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001227."", ""source_locator"": ""./YeastPathways_PWY3O-4112.json#/facts/61; endpoint types: /individuals/73/type; /individuals/76/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4112"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json"", ""title"": ""SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_location-7f1495b92dc9_15b7e30fcc24	SGD:S000005446	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00330	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	"[{""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00330"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00330 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_location-48b2842e8c03_a680358af91e	SGD:S000002788	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06408	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2752/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 has the exact SGD cross-reference SGD:S000002788."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2752/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q06408"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06408 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_location-5a706de09f76_e09347f77b79	SGD:S000003909	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47176	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:21267457); ECO:0000269 (PubMed:8798704)	"[{""reference_id"": ""UniProtKB:P47176"", ""source_assertion"": ""UniProtKB:P47176 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1987/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P47176"", ""source_assertion"": ""UniProtKB:P47176 has the exact SGD cross-reference SGD:S000003909."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1987/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P47176"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47176 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_location-b80b4f1b750d_84c5b27b5591	SGD:S000002327	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32771	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32771"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32771 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_location-091fe2fe90d3_cb35767534f7	SGD:S000002327	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32771	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961)	"[{""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32771"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32771 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_location-f9bd1202481b_bd7c8da2a36b	SGD:S000001251	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38891	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:21267457); ECO:0000269 (PubMed:8798704)	"[{""reference_id"": ""UniProtKB:P38891"", ""source_assertion"": ""UniProtKB:P38891 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1497/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38891"", ""source_assertion"": ""UniProtKB:P38891 has the exact SGD cross-reference SGD:S000001251."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1497/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38891"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38891 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_location-36703d5e93fc_64063e715014	SGD:S000004688	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07246	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:1101965); ECO:0000269 (PubMed:2188098); ECO:0000269 (PubMed:2943982)	"[{""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_location-b5d74d4cb0f4_8fdf56c89fd1	SGD:S000004688	RO:0001025	GO:0005743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07246	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	"[{""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 annotates location Mitochondrion inner membrane (SL-0168)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_location-c3e54c00840d_27eecfd9a7d9	SGD:S000003225	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10127	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/302/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/302/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P10127"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P10127 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_location-07b1015cc728_541b500b2a50	SGD:S000000349	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38113	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38113"", ""source_assertion"": ""UniProtKB:P38113 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3563/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38113"", ""source_assertion"": ""UniProtKB:P38113 has the exact SGD cross-reference SGD:S000000349."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3563/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38113"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38113 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_location-83d9f7cee755_223c4bb25d03	SGD:S000004918	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00331	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:2937632)	"[{""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00331"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00331 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_cofactor-d020d7cd99ba_59e1d0aabbbc	SGD:S000005446	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00330	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849)	"[{""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/comments/0/cofactors/0; /results/22/comments/0/note""}, {""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00330"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00330 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_cofactor-94921f5c2d4f_2db460be7a52	SGD:S000002788	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06408	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/comments/0/cofactors/0; /results/2752/comments/0/note""}, {""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 has the exact SGD cross-reference SGD:S000002788."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q06408"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06408 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_cofactor-2aff8723af5a_2a30018d55cb	SGD:S000002788	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06408	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/comments/1/cofactors/0; /results/2752/comments/1/note""}, {""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 has the exact SGD cross-reference SGD:S000002788."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q06408"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06408 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_cofactor-41b7855c2473_5d0624f8fac7	SGD:S000003909	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47176	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P47176"", ""source_assertion"": ""UniProtKB:P47176 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1987/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P47176"", ""source_assertion"": ""UniProtKB:P47176 has the exact SGD cross-reference SGD:S000003909."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1987/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P47176"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47176 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_cofactor-5ec0450d58bc_e5588d4e907a	SGD:S000002327	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32771	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06525) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06525)	"[{""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/990/comments/0/cofactors/0; /results/990/comments/0/note""}, {""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/990/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32771"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32771 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_cofactor-2ed218c0aed2_18fbb6e28273	SGD:S000001251	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38891	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: Disputed growth phenotypes do not address PLP binding; retain the similarity-based PLP annotation. UniProt evidence: ECO:0000250 (UniProtKB:P0AB80)	"[{""reference_id"": ""UniProtKB:P38891"", ""source_assertion"": ""UniProtKB:P38891 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1497/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P38891"", ""source_assertion"": ""UniProtKB:P38891 has the exact SGD cross-reference SGD:S000001251."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1497/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38891"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38891 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_cofactor-738cd0b35ac6_b179caf3464c	SGD:S000004688	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07246	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	"[{""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/comments/0/cofactors/0; /results/161/comments/0/note""}, {""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P07246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_cofactor-a5e2dcd48dc5_566d209c8585	SGD:S000003225	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10127	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3282541) Zinc. May bind iron when zinc levels are limiting. UniProt note evidence: ECO:0000269 (PubMed:3282541)	"[{""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/comments/0/cofactors/0; /results/302/comments/0/note""}, {""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P10127"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P10127 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_cofactor-ae583f346b28_0c68e32c9e50	SGD:S000003225	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10127	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3282541) Zinc. May bind iron when zinc levels are limiting. UniProt note evidence: ECO:0000269 (PubMed:3282541)	"[{""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 annotates CHEBI:29033 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/comments/0/cofactors/1; /results/302/comments/0/note""}, {""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P10127"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P10127 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_cofactor-339a304fe175_45abce5909e4	SGD:S000000349	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38113	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	"[{""reference_id"": ""UniProtKB:P38113"", ""source_assertion"": ""UniProtKB:P38113 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3563/comments/0/cofactors/0; /results/3563/comments/0/note""}, {""reference_id"": ""UniProtKB:P38113"", ""source_assertion"": ""UniProtKB:P38113 has the exact SGD cross-reference SGD:S000000349."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3563/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38113"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38113 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4112_cofactor-ea44646ed080_74d0a5a669c6	SGD:S000004918	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00331	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	"[{""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/comments/0/cofactors/0; /results/23/comments/0/note""}, {""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00331"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00331 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MIBiG_BGC0002072_causal-review-1_1f8630f2c9fe	NCBIProtein:AKL64828.1	pathwaymech:enables	MIBiG:BGC0002072	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:28919037	Genetic requirement for pathway output; this does not assert a specific starter-substrate reaction.	"[{""reference_id"": ""PMID:28919037"", ""source_assertion"": ""Deleting lnyI eliminates detectable linearmycins A, B and C; complementation restores production."", ""source_locator"": ""Results: lnyI deletion and complementation; HPLC profiles""}]"	"[{""id"": ""PMID:28919037"", ""title"": ""A Link between Linearmycin Biosynthesis and Extracellular Vesicle Genesis Connects Specialized Metabolism and Bacterial Membrane Physiology"", ""url"": ""https://doi.org/10.1016/j.chembiol.2017.08.008""}]"	""
pathwaymech:MIBiG_BGC0002072_causal-review-2_a5e1e501f515	MIBiG:BGC0002072	pathwaymech:produces	CHEBI:202459	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:28919037		"[{""reference_id"": ""PMID:28919037"", ""source_assertion"": ""Linearmycin A was detected among Streptomyces sp. Mg1 linearmycin products in the production and mutant experiments."", ""source_locator"": ""Results: linearmycin identification and lnyI mutant/complement HPLC profiles""}]"	"[{""id"": ""PMID:28919037"", ""title"": ""A Link between Linearmycin Biosynthesis and Extracellular Vesicle Genesis Connects Specialized Metabolism and Bacterial Membrane Physiology"", ""url"": ""https://doi.org/10.1016/j.chembiol.2017.08.008""}]"	""
pathwaymech:MIBiG_BGC0002072_causal-review-3_2fa282fbe566	MIBiG:BGC0002072	pathwaymech:produces	CHEBI:202416	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:28919037		"[{""reference_id"": ""PMID:28919037"", ""source_assertion"": ""Linearmycin B was detected among Streptomyces sp. Mg1 linearmycin products in the production and mutant experiments."", ""source_locator"": ""Results: linearmycin identification and lnyI mutant/complement HPLC profiles""}]"	"[{""id"": ""PMID:28919037"", ""title"": ""A Link between Linearmycin Biosynthesis and Extracellular Vesicle Genesis Connects Specialized Metabolism and Bacterial Membrane Physiology"", ""url"": ""https://doi.org/10.1016/j.chembiol.2017.08.008""}]"	""
pathwaymech:MIBiG_BGC0002072_causal-review-4_b05d36723b54	MIBiG:BGC0002072	pathwaymech:produces	CHEBI:210490	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:28919037		"[{""reference_id"": ""PMID:28919037"", ""source_assertion"": ""Linearmycin C was detected among Streptomyces sp. Mg1 linearmycin products in the production and mutant experiments."", ""source_locator"": ""Results: linearmycin identification and lnyI mutant/complement HPLC profiles""}]"	"[{""id"": ""PMID:28919037"", ""title"": ""A Link between Linearmycin Biosynthesis and Extracellular Vesicle Genesis Connects Specialized Metabolism and Bacterial Membrane Physiology"", ""url"": ""https://doi.org/10.1016/j.chembiol.2017.08.008""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-001_9b3bc2355867	gomodel:6882d2b800000609/6882d2b800000646	pathwaymech:enables	gomodel:6882d2b800000609/6882d2b800000645	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000645 RO:0002333 gomodel:6882d2b800000609/6882d2b800000646."", ""source_locator"": ""./6882d2b800000609.json#/facts/0; endpoint types: /individuals/31/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-002_7e281ab2a516	gomodel:6882d2b800000609/6882d2b800000638	BFO:0000050	GO:0009245	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000638 BFO:0000050 gomodel:6882d2b800000609/6882d2b800000640."", ""source_locator"": ""./6882d2b800000609.json#/facts/1; endpoint types: /individuals/24/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-003_96fcf74d255f	gomodel:6882d2b800000609/6882d2b800000632	BFO:0000050	GO:0009245	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000632 BFO:0000050 gomodel:6882d2b800000609/6882d2b800000636."", ""source_locator"": ""./6882d2b800000609.json#/facts/2; endpoint types: /individuals/18/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-004_fd457b73b21e	gomodel:6882d2b800000609/6882d2b800000639	pathwaymech:enables	gomodel:6882d2b800000609/6882d2b800000638	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000638 RO:0002333 gomodel:6882d2b800000609/6882d2b800000639."", ""source_locator"": ""./6882d2b800000609.json#/facts/3; endpoint types: /individuals/24/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-005_a0a289f20637	gomodel:6882d2b800000609/6882d2b800000652	BFO:0000066	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000652 BFO:0000066 gomodel:6882d2b800000609/6882d2b800000655."", ""source_locator"": ""./6882d2b800000609.json#/facts/4; endpoint types: /individuals/38/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-006_bad6621afbd8	gomodel:6882d2b800000609/6882d2b800000632	BFO:0000066	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000632 BFO:0000066 gomodel:6882d2b800000609/6882d2b800000665."", ""source_locator"": ""./6882d2b800000609.json#/facts/5; endpoint types: /individuals/18/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-007_de89bbb9365a	gomodel:6882d2b800000609/6882d2b800000638	BFO:0000066	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000638 BFO:0000066 gomodel:6882d2b800000609/6882d2b800000663."", ""source_locator"": ""./6882d2b800000609.json#/facts/6; endpoint types: /individuals/24/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-008_a672eb47f55c	gomodel:6882d2b800000609/6882d2b800000610	BFO:0000050	GO:0009245	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000610 BFO:0000050 gomodel:6882d2b800000609/69c59f8a00000884."", ""source_locator"": ""./6882d2b800000609.json#/facts/7; endpoint types: /individuals/10/type; /individuals/67/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-009_bf4279a0a15d	gomodel:6882d2b800000609/6882d2b800000627	BFO:0000050	GO:0009245	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000627 BFO:0000050 gomodel:6882d2b800000609/6882d2b800000629."", ""source_locator"": ""./6882d2b800000609.json#/facts/8; endpoint types: /individuals/13/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-010_f382e82f0a82	gomodel:6882d2b800000609/6882d2b800000652	RO:0002233	CHEBI:176343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000652 RO:0002233 gomodel:6882d2b800000609/6882d2b800000675."", ""source_locator"": ""./6882d2b800000609.json#/facts/9; endpoint types: /individuals/38/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-011_3c5085cf2c54	gomodel:6882d2b800000609/6882d2b800000632	RO:0002233	CHEBI:137740	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000632 RO:0002233 gomodel:6882d2b800000609/6882d2b800000672."", ""source_locator"": ""./6882d2b800000609.json#/facts/10; endpoint types: /individuals/18/type; /individuals/58/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-012_1e2d26426387	gomodel:6882d2b800000609/6882d2b800000627	BFO:0000066	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000627 BFO:0000066 gomodel:6882d2b800000609/6882d2b800000667."", ""source_locator"": ""./6882d2b800000609.json#/facts/11; endpoint types: /individuals/13/type; /individuals/53/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-013_88f6eca4a525	gomodel:6882d2b800000609/6882d2b800000632	RO:0002234	CHEBI:78847	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000632 RO:0002234 gomodel:6882d2b800000609/6882d2b800000673."", ""source_locator"": ""./6882d2b800000609.json#/facts/12; endpoint types: /individuals/18/type; /individuals/59/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-014_673337c9ce98	gomodel:6882d2b800000609/6882d2b800000645	BFO:0000050	GO:0009245	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000645 BFO:0000050 gomodel:6882d2b800000609/6882d2b800000647."", ""source_locator"": ""./6882d2b800000609.json#/facts/13; endpoint types: /individuals/31/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-015_3f4134a96728	gomodel:6882d2b800000609/6882d2b800000627	RO:0002234	CHEBI:137740	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000627 RO:0002234 gomodel:6882d2b800000609/6882d2b800000672."", ""source_locator"": ""./6882d2b800000609.json#/facts/14; endpoint types: /individuals/13/type; /individuals/58/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-016_a0e48f050756	gomodel:6882d2b800000609/6882d2b800000645	RO:0002233	CHEBI:57957	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000645 RO:0002233 gomodel:6882d2b800000609/6882d2b800000674."", ""source_locator"": ""./6882d2b800000609.json#/facts/15; endpoint types: /individuals/31/type; /individuals/60/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-017_f2ffc15290f4	gomodel:6882d2b800000609/6882d2b800000611	pathwaymech:enables	gomodel:6882d2b800000609/6882d2b800000610	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000610 RO:0002333 gomodel:6882d2b800000609/6882d2b800000611."", ""source_locator"": ""./6882d2b800000609.json#/facts/16; endpoint types: /individuals/10/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-018_b7d755cb0a48	gomodel:6882d2b800000609/6882d2b800000652	BFO:0000050	GO:0009245	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000652 BFO:0000050 gomodel:6882d2b800000609/6882d2b800000654."", ""source_locator"": ""./6882d2b800000609.json#/facts/17; endpoint types: /individuals/38/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-019_a9afec2b219f	gomodel:6882d2b800000609/6882d2b800000627	RO:0002233	CHEBI:173225	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000627 RO:0002233 gomodel:6882d2b800000609/6882d2b800000671."", ""source_locator"": ""./6882d2b800000609.json#/facts/18; endpoint types: /individuals/13/type; /individuals/57/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-020_79571e4fd39b	gomodel:6882d2b800000609/6882d2b800000645	BFO:0000066	GO:0019897	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000645 BFO:0000066 gomodel:6882d2b800000609/6882d2b800000661."", ""source_locator"": ""./6882d2b800000609.json#/facts/19; endpoint types: /individuals/31/type; /individuals/47/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-021_eaab7816c785	gomodel:6882d2b800000609/6882d2b800000645	RO:0002234	CHEBI:176343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000645 RO:0002234 gomodel:6882d2b800000609/6882d2b800000675."", ""source_locator"": ""./6882d2b800000609.json#/facts/20; endpoint types: /individuals/31/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-022_a7f8b24c57d8	gomodel:6882d2b800000609/6882d2b800000638	RO:0002234	CHEBI:57957	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000638 RO:0002234 gomodel:6882d2b800000609/6882d2b800000674."", ""source_locator"": ""./6882d2b800000609.json#/facts/21; endpoint types: /individuals/24/type; /individuals/60/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-023_65e82d2ff105	gomodel:6882d2b800000609/6882d2b800000633	pathwaymech:enables	gomodel:6882d2b800000609/6882d2b800000632	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000632 RO:0002333 gomodel:6882d2b800000609/6882d2b800000633."", ""source_locator"": ""./6882d2b800000609.json#/facts/22; endpoint types: /individuals/18/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-024_1913e3007aa1	gomodel:6882d2b800000609/6882d2b800000652	RO:0002234	CHEBI:176425	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000652 RO:0002234 gomodel:6882d2b800000609/6882d2b800000678."", ""source_locator"": ""./6882d2b800000609.json#/facts/23; endpoint types: /individuals/38/type; /individuals/62/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-025_69749d091d3d	gomodel:6882d2b800000609/6882d2b800000653	pathwaymech:enables	gomodel:6882d2b800000609/6882d2b800000652	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000652 RO:0002333 gomodel:6882d2b800000609/6882d2b800000653."", ""source_locator"": ""./6882d2b800000609.json#/facts/24; endpoint types: /individuals/38/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-026_0f1b312ad37a	gomodel:6882d2b800000609/6882d2b800000638	RO:0002233	CHEBI:78847	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000638 RO:0002233 gomodel:6882d2b800000609/6882d2b800000673."", ""source_locator"": ""./6882d2b800000609.json#/facts/25; endpoint types: /individuals/24/type; /individuals/59/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-027_e726f0b8d545	gomodel:6882d2b800000609/6882d2b800000610	RO:0002233	CHEBI:16264	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000610 RO:0002233 gomodel:6882d2b800000609/6882d2b800000681."", ""source_locator"": ""./6882d2b800000609.json#/facts/26; endpoint types: /individuals/10/type; /individuals/65/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-028_98e40392f77c	gomodel:6882d2b800000609/6882d2b800000610	RO:0002234	CHEBI:173225	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000610 RO:0002234 gomodel:6882d2b800000609/6882d2b800000671."", ""source_locator"": ""./6882d2b800000609.json#/facts/27; endpoint types: /individuals/10/type; /individuals/57/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-029_1093ed0f199c	gomodel:6882d2b800000609/6882d2b800000610	BFO:0000066	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000610 BFO:0000066 gomodel:6882d2b800000609/6882d2b800000669."", ""source_locator"": ""./6882d2b800000609.json#/facts/28; endpoint types: /individuals/10/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_edge-030_97a2b0388653	gomodel:6882d2b800000609/6882d2b800000628	pathwaymech:enables	gomodel:6882d2b800000609/6882d2b800000627	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:6882d2b800000609		"[{""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The model asserts gomodel:6882d2b800000609/6882d2b800000627 RO:0002333 gomodel:6882d2b800000609/6882d2b800000628."", ""source_locator"": ""./6882d2b800000609.json#/facts/29; endpoint types: /individuals/13/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_cofactor-3a4351d53560_c8bf98735f73	gomodel:6882d2b800000609/6882d2b800000639	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P43341|gomodel:6882d2b800000609	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_00575); ECO:0000305 (PubMed:12000770) Binds 2 Mn(2+) ions per subunit in a binuclear metal center. UniProt note evidence: ECO:0000255 (HAMAP-Rule:MF_00575)	"[{""reference_id"": ""UniProtKB:P43341"", ""source_assertion"": ""UniProtKB:P43341 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A83333+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_biocyc%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:754f9ed81673546fc431e009c1b979e9ce6db9cd2cc9b24ef62b5fdd1c3204e7] #/results/1299/comments/0/cofactors/0; /results/1299/comments/0/note""}, {""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The native individual gomodel:6882d2b800000609/6882d2b800000639 has type EcoCyc:EG12666-MONOMER."", ""source_locator"": ""./6882d2b800000609.json#/individuals/25/type/0""}, {""reference_id"": ""UniProtKB:P43341"", ""source_assertion"": ""Reviewed UniProtKB:P43341 has the exact BioCyc cross-reference EcoCyc:EG12666-MONOMER; this joins the native model protein to its cofactor annotation."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A83333+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_biocyc%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:754f9ed81673546fc431e009c1b979e9ce6db9cd2cc9b24ef62b5fdd1c3204e7] #/results/1299/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P43341"", ""source_sha256"": ""754f9ed81673546fc431e009c1b979e9ce6db9cd2cc9b24ef62b5fdd1c3204e7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P43341 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A83333+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_biocyc%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}, {""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_cofactor-31f1f5d6c232_377cd85702d1	gomodel:6882d2b800000609/6882d2b800000628	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A725|gomodel:6882d2b800000609	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_00388); ECO:0000269 (PubMed:10026271); ECO:0000269 (PubMed:20709752) Can use either Fe(2+) or Zn(2+). The metal cofactor can switch between Fe(2+) and Zn(2+) in response to metal availability. Metal switching may be important for regulating the LpxC activity upon changes in environmental conditions. Has a significantly higher affinity for Zn(2+), but exhibits higher activity with Fe(2+) (PubMed:20136146, PubMed:20709752). Can also use Co(2+), Ni(2+) and, to a lesser extent, Mn(2+) (PubMed:10026271). UniProt note evidence: ECO:0000269 (PubMed:10026271); ECO:0000269 (PubMed:20136146); ECO:0000269 (PubMed:20709752)	"[{""reference_id"": ""UniProtKB:P0A725"", ""source_assertion"": ""UniProtKB:P0A725 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A83333+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_biocyc%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:754f9ed81673546fc431e009c1b979e9ce6db9cd2cc9b24ef62b5fdd1c3204e7] #/results/258/comments/0/cofactors/0; /results/258/comments/0/note""}, {""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The native individual gomodel:6882d2b800000609/6882d2b800000628 has type EcoCyc:UDPACYLGLCNACDEACETYL-MONOMER."", ""source_locator"": ""./6882d2b800000609.json#/individuals/14/type/0""}, {""reference_id"": ""UniProtKB:P0A725"", ""source_assertion"": ""Reviewed UniProtKB:P0A725 has the exact BioCyc cross-reference EcoCyc:UDPACYLGLCNACDEACETYL-MONOMER; this joins the native model protein to its cofactor annotation."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A83333+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_biocyc%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:754f9ed81673546fc431e009c1b979e9ce6db9cd2cc9b24ef62b5fdd1c3204e7] #/results/258/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P0A725"", ""source_sha256"": ""754f9ed81673546fc431e009c1b979e9ce6db9cd2cc9b24ef62b5fdd1c3204e7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P0A725 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A83333+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_biocyc%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}, {""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_6882d2b800000609_cofactor-96d15ab0f869_e860149bcf4e	gomodel:6882d2b800000609/6882d2b800000628	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A725|gomodel:6882d2b800000609	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:20136146); ECO:0000269 (PubMed:20709752) Can use either Fe(2+) or Zn(2+). The metal cofactor can switch between Fe(2+) and Zn(2+) in response to metal availability. Metal switching may be important for regulating the LpxC activity upon changes in environmental conditions. Has a significantly higher affinity for Zn(2+), but exhibits higher activity with Fe(2+) (PubMed:20136146, PubMed:20709752). Can also use Co(2+), Ni(2+) and, to a lesser extent, Mn(2+) (PubMed:10026271). UniProt note evidence: ECO:0000269 (PubMed:10026271); ECO:0000269 (PubMed:20136146); ECO:0000269 (PubMed:20709752)	"[{""reference_id"": ""UniProtKB:P0A725"", ""source_assertion"": ""UniProtKB:P0A725 annotates CHEBI:29033 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A83333+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_biocyc%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:754f9ed81673546fc431e009c1b979e9ce6db9cd2cc9b24ef62b5fdd1c3204e7] #/results/258/comments/0/cofactors/1; /results/258/comments/0/note""}, {""reference_id"": ""gomodel:6882d2b800000609"", ""source_assertion"": ""The native individual gomodel:6882d2b800000609/6882d2b800000628 has type EcoCyc:UDPACYLGLCNACDEACETYL-MONOMER."", ""source_locator"": ""./6882d2b800000609.json#/individuals/14/type/0""}, {""reference_id"": ""UniProtKB:P0A725"", ""source_assertion"": ""Reviewed UniProtKB:P0A725 has the exact BioCyc cross-reference EcoCyc:UDPACYLGLCNACDEACETYL-MONOMER; this joins the native model protein to its cofactor annotation."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A83333+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_biocyc%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:754f9ed81673546fc431e009c1b979e9ce6db9cd2cc9b24ef62b5fdd1c3204e7] #/results/258/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P0A725"", ""source_sha256"": ""754f9ed81673546fc431e009c1b979e9ce6db9cd2cc9b24ef62b5fdd1c3204e7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P0A725 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A83333+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_biocyc%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}, {""id"": ""gomodel:6882d2b800000609"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./6882d2b800000609.json"", ""title"": ""GO-CAM lipid IV(A) biosynthesis pathway model 6882d2b800000609"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-001_429f2cb83e3c	RHEA-COMP:9636	pathwaymech:consumes	RHEA:17666	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17666		"[{""reference_id"": ""RHEA:17666"", ""source_assertion"": ""RHEA:17666 assigns RHEA-COMP:9636 to substrates, coefficient 1. Whole carrier states are retained where the source uses a generic polypeptide."", ""source_locator"": ""http://rdf.rhea-db.org/17666 rh:substrates; http://rdf.rhea-db.org/17665_L rh:contains1 http://rdf.rhea-db.org/Participant_17665_compound_9636; rh:compound http://rdf.rhea-db.org/Compound_9636""}]"	"[{""id"": ""RHEA:17666"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 17666"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-002_9b73e210960e	RHEA-COMP:9752	pathwaymech:consumes	RHEA:17666	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17666		"[{""reference_id"": ""RHEA:17666"", ""source_assertion"": ""RHEA:17666 assigns RHEA-COMP:9752 to substrates, coefficient 1. Whole carrier states are retained where the source uses a generic polypeptide."", ""source_locator"": ""http://rdf.rhea-db.org/17666 rh:substrates; http://rdf.rhea-db.org/17665_L rh:contains1 http://rdf.rhea-db.org/Participant_17665_compound_9752; rh:compound http://rdf.rhea-db.org/Compound_9752""}]"	"[{""id"": ""RHEA:17666"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 17666"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-003_cbdae486ddf6	RHEA:17666	pathwaymech:produces	RHEA-COMP:9928	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17666		"[{""reference_id"": ""RHEA:17666"", ""source_assertion"": ""RHEA:17666 assigns RHEA-COMP:9928 to products, coefficient 1. Whole carrier states are retained where the source uses a generic polypeptide."", ""source_locator"": ""http://rdf.rhea-db.org/17666 rh:products; http://rdf.rhea-db.org/17665_R rh:contains1 http://rdf.rhea-db.org/Participant_17665_compound_9928; rh:compound http://rdf.rhea-db.org/Compound_9928""}]"	"[{""id"": ""RHEA:17666"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 17666"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-004_1a87fd396c80	RHEA:17666	pathwaymech:produces	RHEA-COMP:9685	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17666		"[{""reference_id"": ""RHEA:17666"", ""source_assertion"": ""RHEA:17666 assigns RHEA-COMP:9685 to products, coefficient 1. Whole carrier states are retained where the source uses a generic polypeptide."", ""source_locator"": ""http://rdf.rhea-db.org/17666 rh:products; http://rdf.rhea-db.org/17665_R rh:contains1 http://rdf.rhea-db.org/Participant_17665_compound_9685; rh:compound http://rdf.rhea-db.org/Compound_9685""}]"	"[{""id"": ""RHEA:17666"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 17666"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-005_87b737f39072	RHEA:17666	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17666		"[{""reference_id"": ""RHEA:17666"", ""source_assertion"": ""RHEA:17666 assigns CHEBI:15378 to products, coefficient 1. Whole carrier states are retained where the source uses a generic polypeptide."", ""source_locator"": ""http://rdf.rhea-db.org/17666 rh:products; http://rdf.rhea-db.org/17665_R rh:contains1 http://rdf.rhea-db.org/Participant_17665_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249""}]"	"[{""id"": ""RHEA:17666"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 17666"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-006_4620dc64f1d1	RHEA-COMP:14568	pathwaymech:consumes	RHEA:16586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16586	Current Rhea net equation, including its Fe(III)/ferredoxin convention; this is not a measured physiological electron balance. MetaCyc 22.5 instead releases Fe(II), consumes reduced ferredoxin and uses six hydrons. The complete source discrepancy is retained in the curation ledger.	"[{""reference_id"": ""RHEA:16586"", ""source_assertion"": ""RHEA:16586 assigns RHEA-COMP:14568 to substrates, coefficient 1. Whole carrier states are retained where the source uses a generic polypeptide."", ""source_locator"": ""http://rdf.rhea-db.org/16586 rh:substrates; http://rdf.rhea-db.org/16585_L rh:contains1 http://rdf.rhea-db.org/Participant_16585_compound_14568; rh:compound http://rdf.rhea-db.org/Compound_14568""}]"	"[{""id"": ""RHEA:16586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 16586"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-007_0d9c03bc204b	RHEA-COMP:9928	pathwaymech:consumes	RHEA:16586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16586	Current Rhea net equation, including its Fe(III)/ferredoxin convention; this is not a measured physiological electron balance. MetaCyc 22.5 instead releases Fe(II), consumes reduced ferredoxin and uses six hydrons. The complete source discrepancy is retained in the curation ledger.	"[{""reference_id"": ""RHEA:16586"", ""source_assertion"": ""RHEA:16586 assigns RHEA-COMP:9928 to substrates, coefficient 1. Whole carrier states are retained where the source uses a generic polypeptide."", ""source_locator"": ""http://rdf.rhea-db.org/16586 rh:substrates; http://rdf.rhea-db.org/16585_L rh:contains1 http://rdf.rhea-db.org/Participant_16585_compound_9928; rh:compound http://rdf.rhea-db.org/Compound_9928""}]"	"[{""id"": ""RHEA:16586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 16586"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-008_804361ca2d7b	RHEA-COMP:10000	pathwaymech:consumes	RHEA:16586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16586	Current Rhea net equation, including its Fe(III)/ferredoxin convention; this is not a measured physiological electron balance. MetaCyc 22.5 instead releases Fe(II), consumes reduced ferredoxin and uses six hydrons. The complete source discrepancy is retained in the curation ledger.	"[{""reference_id"": ""RHEA:16586"", ""source_assertion"": ""RHEA:16586 assigns RHEA-COMP:10000 to substrates, coefficient 2. Whole carrier states are retained where the source uses a generic polypeptide."", ""source_locator"": ""http://rdf.rhea-db.org/16586 rh:substrates; http://rdf.rhea-db.org/16585_L rh:contains2 http://rdf.rhea-db.org/Participant_16585_compound_10000; rh:compound http://rdf.rhea-db.org/Compound_10000""}]"	"[{""id"": ""RHEA:16586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 16586"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-009_0f6edbb274d9	CHEBI:59789	pathwaymech:consumes	RHEA:16586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16586	Current Rhea net equation, including its Fe(III)/ferredoxin convention; this is not a measured physiological electron balance. MetaCyc 22.5 instead releases Fe(II), consumes reduced ferredoxin and uses six hydrons. The complete source discrepancy is retained in the curation ledger.	"[{""reference_id"": ""RHEA:16586"", ""source_assertion"": ""RHEA:16586 assigns CHEBI:59789 to substrates, coefficient 2. Whole carrier states are retained where the source uses a generic polypeptide."", ""source_locator"": ""http://rdf.rhea-db.org/16586 rh:substrates; http://rdf.rhea-db.org/16585_L rh:contains2 http://rdf.rhea-db.org/Participant_16585_compound_6127; rh:compound http://rdf.rhea-db.org/Compound_6127""}]"	"[{""id"": ""RHEA:16586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 16586"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-010_0703fc5f452a	CHEBI:15378	pathwaymech:consumes	RHEA:16586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16586	Current Rhea net equation, including its Fe(III)/ferredoxin convention; this is not a measured physiological electron balance. MetaCyc 22.5 instead releases Fe(II), consumes reduced ferredoxin and uses six hydrons. The complete source discrepancy is retained in the curation ledger.	"[{""reference_id"": ""RHEA:16586"", ""source_assertion"": ""RHEA:16586 assigns CHEBI:15378 to substrates, coefficient 4. Whole carrier states are retained where the source uses a generic polypeptide."", ""source_locator"": ""http://rdf.rhea-db.org/16586 rh:substrates; http://rdf.rhea-db.org/16585_L rh:contains4 http://rdf.rhea-db.org/Participant_16585_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249""}]"	"[{""id"": ""RHEA:16586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 16586"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-011_4fb0e18d6a05	RHEA:16586	pathwaymech:produces	RHEA-COMP:14569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16586	Current Rhea net equation, including its Fe(III)/ferredoxin convention; this is not a measured physiological electron balance. MetaCyc 22.5 instead releases Fe(II), consumes reduced ferredoxin and uses six hydrons. The complete source discrepancy is retained in the curation ledger.	"[{""reference_id"": ""RHEA:16586"", ""source_assertion"": ""RHEA:16586 assigns RHEA-COMP:14569 to products, coefficient 1. Whole carrier states are retained where the source uses a generic polypeptide."", ""source_locator"": ""http://rdf.rhea-db.org/16586 rh:products; http://rdf.rhea-db.org/16585_R rh:contains1 http://rdf.rhea-db.org/Participant_16585_compound_14569; rh:compound http://rdf.rhea-db.org/Compound_14569""}]"	"[{""id"": ""RHEA:16586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 16586"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-012_574006daa13d	RHEA:16586	pathwaymech:produces	RHEA-COMP:10475	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16586	Current Rhea net equation, including its Fe(III)/ferredoxin convention; this is not a measured physiological electron balance. MetaCyc 22.5 instead releases Fe(II), consumes reduced ferredoxin and uses six hydrons. The complete source discrepancy is retained in the curation ledger.	"[{""reference_id"": ""RHEA:16586"", ""source_assertion"": ""RHEA:16586 assigns RHEA-COMP:10475 to products, coefficient 1. Whole carrier states are retained where the source uses a generic polypeptide."", ""source_locator"": ""http://rdf.rhea-db.org/16586 rh:products; http://rdf.rhea-db.org/16585_R rh:contains1 http://rdf.rhea-db.org/Participant_16585_compound_10475; rh:compound http://rdf.rhea-db.org/Compound_10475""}]"	"[{""id"": ""RHEA:16586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 16586"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-013_b1823c561e25	RHEA:16586	pathwaymech:produces	CHEBI:29034	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16586	Current Rhea net equation, including its Fe(III)/ferredoxin convention; this is not a measured physiological electron balance. MetaCyc 22.5 instead releases Fe(II), consumes reduced ferredoxin and uses six hydrons. The complete source discrepancy is retained in the curation ledger.	"[{""reference_id"": ""RHEA:16586"", ""source_assertion"": ""RHEA:16586 assigns CHEBI:29034 to products, coefficient 4. Whole carrier states are retained where the source uses a generic polypeptide."", ""source_locator"": ""http://rdf.rhea-db.org/16586 rh:products; http://rdf.rhea-db.org/16585_R rh:contains4 http://rdf.rhea-db.org/Participant_16585_compound_4615; rh:compound http://rdf.rhea-db.org/Compound_4615""}]"	"[{""id"": ""RHEA:16586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 16586"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-014_27f2bda67118	RHEA:16586	pathwaymech:produces	CHEBI:29919	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16586	Current Rhea net equation, including its Fe(III)/ferredoxin convention; this is not a measured physiological electron balance. MetaCyc 22.5 instead releases Fe(II), consumes reduced ferredoxin and uses six hydrons. The complete source discrepancy is retained in the curation ledger.	"[{""reference_id"": ""RHEA:16586"", ""source_assertion"": ""RHEA:16586 assigns CHEBI:29919 to products, coefficient 2. Whole carrier states are retained where the source uses a generic polypeptide."", ""source_locator"": ""http://rdf.rhea-db.org/16586 rh:products; http://rdf.rhea-db.org/16585_R rh:contains2 http://rdf.rhea-db.org/Participant_16585_compound_3841; rh:compound http://rdf.rhea-db.org/Compound_3841""}]"	"[{""id"": ""RHEA:16586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 16586"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-015_122de46f29ef	RHEA:16586	pathwaymech:produces	CHEBI:17319	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16586	Current Rhea net equation, including its Fe(III)/ferredoxin convention; this is not a measured physiological electron balance. MetaCyc 22.5 instead releases Fe(II), consumes reduced ferredoxin and uses six hydrons. The complete source discrepancy is retained in the curation ledger.	"[{""reference_id"": ""RHEA:16586"", ""source_assertion"": ""RHEA:16586 assigns CHEBI:17319 to products, coefficient 2. Whole carrier states are retained where the source uses a generic polypeptide."", ""source_locator"": ""http://rdf.rhea-db.org/16586 rh:products; http://rdf.rhea-db.org/16585_R rh:contains2 http://rdf.rhea-db.org/Participant_16585_compound_2028; rh:compound http://rdf.rhea-db.org/Compound_2028""}]"	"[{""id"": ""RHEA:16586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 16586"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-016_ef193db946b8	RHEA:16586	pathwaymech:produces	CHEBI:57844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16586	Current Rhea net equation, including its Fe(III)/ferredoxin convention; this is not a measured physiological electron balance. MetaCyc 22.5 instead releases Fe(II), consumes reduced ferredoxin and uses six hydrons. The complete source discrepancy is retained in the curation ledger.	"[{""reference_id"": ""RHEA:16586"", ""source_assertion"": ""RHEA:16586 assigns CHEBI:57844 to products, coefficient 2. Whole carrier states are retained where the source uses a generic polypeptide."", ""source_locator"": ""http://rdf.rhea-db.org/16586 rh:products; http://rdf.rhea-db.org/16585_R rh:contains2 http://rdf.rhea-db.org/Participant_16585_compound_2530; rh:compound http://rdf.rhea-db.org/Compound_2530""}]"	"[{""id"": ""RHEA:16586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 16586"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-017_dcc91d6f2935	RHEA:16586	pathwaymech:produces	RHEA-COMP:10001	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16586	Current Rhea net equation, including its Fe(III)/ferredoxin convention; this is not a measured physiological electron balance. MetaCyc 22.5 instead releases Fe(II), consumes reduced ferredoxin and uses six hydrons. The complete source discrepancy is retained in the curation ledger.	"[{""reference_id"": ""RHEA:16586"", ""source_assertion"": ""RHEA:16586 assigns RHEA-COMP:10001 to products, coefficient 2. Whole carrier states are retained where the source uses a generic polypeptide."", ""source_locator"": ""http://rdf.rhea-db.org/16586 rh:products; http://rdf.rhea-db.org/16585_R rh:contains2 http://rdf.rhea-db.org/Participant_16585_compound_10001; rh:compound http://rdf.rhea-db.org/Compound_10001""}]"	"[{""id"": ""RHEA:16586"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 16586"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-018_306c12f07578	UniProtKB:P60720	pathwaymech:catalyzes	RHEA:17666	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12591875|PMID:15642479|PMID:16342964|RHEA:17666|UniProtKB:P60720	The protein node includes the experimentally annotated active monomer; a separate stable external homotrimer identity was not established. Selecting physiological transfer does not deny the measured reverse reaction.	"[{""reference_id"": ""UniProtKB:P60720"", ""source_assertion"": ""K-12 LipB FUNCTION supports octanoyl transfer with experimental citations 15642479/16342964; the separate RHEA:17665 catalytic annotation is HAMAP ECO:0000255. SUBUNIT reports active monomer and homotrimer with ECO:0000269 PMID:15642479."", ""source_locator"": ""/organism/taxonId; /comments/0; /comments/1; /comments/4""}, {""reference_id"": ""PMID:12591875"", ""source_assertion"": ""Purified E. coli LipB transfers octanoyl or lipoyl groups from ACP thioesters to a pyruvate-dehydrogenase lipoyl domain. The upstream TTG start yields functional protein; the historically assigned ATG yields an inactive truncated form."", ""source_locator"": ""/resultList/result[id=\""12591875\""]/abstractText""}, {""reference_id"": ""PMID:15642479"", ""source_assertion"": ""The primary abstract reports purified LipB transfer of octanoyl-ACP to apo-H protein, with apparent Km values for both substrates. It does not separately document the oligomer comparison in the inspected abstract."", ""source_locator"": ""/resultList/result[id=\""15642479\""]/abstractText""}, {""reference_id"": ""PMID:16342964"", ""source_assertion"": ""An isolated octanoyl-C169 LipB thioester transfers its acyl group to an E. coli PDH domain or back to ACP; the paper supports an acyl-enzyme mechanism and reversibility in vitro."", ""source_locator"": ""/resultList/result[id=\""16342964\""]/abstractText""}, {""reference_id"": ""RHEA:17666"", ""source_assertion"": ""RHEA:17665 links directional member RHEA:17666; the selected left-to-right member is the physiological octanoyl transfer."", ""source_locator"": ""http://rdf.rhea-db.org/17665 rh:directionalReaction http://rdf.rhea-db.org/17666""}]"	"[{""id"": ""PMID:12591875"", ""source_sha256"": ""a472b6d22088bb8303fa27ab19f3d4e4c8a1e3030a21e8b36f1fba0d7e702da7"", ""source_version"": ""2003; primary indexed abstract inspected via Europe PMC core JSON, not full article; digest covers retained response"", ""title"": ""The Escherichia coli lipB gene encodes lipoyl (octanoyl)-acyl carrier protein:protein transferase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12591875/""}, {""id"": ""PMID:15642479"", ""source_sha256"": ""feeb415dc45af7e45640ef7f025ac748d60d8d925c37538fcb81a5d502fa15dd"", ""source_version"": ""2005; primary indexed abstract inspected via Europe PMC core JSON, not full article; digest covers retained response"", ""title"": ""Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/15642479/""}, {""id"": ""PMID:16342964"", ""source_sha256"": ""b33094913a12253642bb60d6ace6773250732e89ef69285b05e18b17c4f8335c"", ""source_version"": ""2005; primary indexed abstract inspected via Europe PMC core JSON, not full article; digest covers retained response"", ""title"": ""The reaction of LipB, the octanoyl-[acyl carrier protein]:protein N-octanoyltransferase of lipoic acid synthesis, proceeds through an acyl-enzyme intermediate."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/16342964/""}, {""id"": ""RHEA:17666"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 17666"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P60720"", ""source_sha256"": ""ad34e89fdedc2381f53895fbb1f7c2eaee6a3ca20e1899f97eab0a5bdc3012ca"", ""source_version"": ""UniProt 2026_03; full current entry retrieved 2026-10-11 UTC"", ""title"": ""Octanoyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60720.json""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-019_10d7a309e14d	MetaCyc:CPLX0-782	pathwaymech:catalyzes	RHEA:16586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN0-949|PMID:14700636|PMID:15157071|PMID:15740115|UniProtKB:P60716	The catalyst is the native annotated dimer, not an assertion that only dimers can function. Current UniProt also allows monomers. The 2004 two-polypeptide mechanistic interpretation is qualified by the 2005 same-polypeptide sulfur result; neither proves every formal Rhea redox participant in vivo.	"[{""reference_id"": ""MetaCyc:RXN0-949"", ""source_assertion"": ""RXN0-949 lists ENZRXN0-1087 with catalyst CPLX0-782 and explicitly unifies RHEA:16586. Core octanoyl-to-dihydrolipoyl chemistry agrees, while formal iron/ferredoxin/hydron conventions differ from Rhea 142."", ""source_locator"": ""Reaction[@frameid=\""RXN0-949\""]/enzymatic-reaction; dblink[dblink-db=\""RHEA\""]; left; right""}, {""reference_id"": ""UniProtKB:P60716"", ""source_assertion"": ""Reviewed K-12 LipA supports sulfur insertion into protein-bound octanoyl groups, not free octanoate. Its catalytic activity links RHEA:16585 with HAMAP inference and experimental PMID:15157071."", ""source_locator"": ""/organism/taxonId; /comments/0; /comments/1""}, {""reference_id"": ""PMID:14700636"", ""source_assertion"": ""Restoring LipA converted a deuterated octanoyl PDH domain to a lipoylated domain. Octanoyl-domain and octanoyl-PDH substrates also underwent sulfur insertion in vitro."", ""source_locator"": ""/resultList/result[id=\""14700636\""]/abstractText""}, {""reference_id"": ""PMID:15157071"", ""source_assertion"": ""Octanoylated glycine-cleavage H protein is a LipA substrate. Deuterium transfer and two SAM cleavages per formed lipoyl group support radical attack on the protein-bound chain."", ""source_locator"": ""/resultList/result[id=\""15157071\""]/abstractText""}, {""reference_id"": ""PMID:15740115"", ""source_assertion"": ""The primary experiment identifies LipA itself as the sulfur source and finds that both sulfur atoms of a lipoyl group derive from the same polypeptide."", ""source_locator"": ""/resultList/result[id=\""15740115\""]/abstractText""}]"	"[{""id"": ""MetaCyc:RXN0-949"", ""source_sha256"": ""6cf86334548c16e9c79ce3baac56d57b97826812a1f9c450b4bcb289df1ee383"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""lipoyl synthase reaction; native redox convention"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-949""}, {""id"": ""PMID:14700636"", ""source_sha256"": ""e11ccc42fbf832f87e65fb77cbd34056dfc7a35de461fc14910ee27be68aac6b"", ""source_version"": ""2003; primary indexed abstract inspected via Europe PMC core JSON, not full article; digest covers retained response"", ""title"": ""Assembly of the covalent linkage between lipoic acid and its cognate enzymes."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/14700636/""}, {""id"": ""PMID:15157071"", ""source_sha256"": ""1b3e264d65e394390d51627c27424f8a262d4e854e106d8e09fa420766a5a536"", ""source_version"": ""2004; primary indexed abstract inspected via Europe PMC core JSON, not full article; digest covers retained response"", ""title"": ""Lipoyl synthase requires two equivalents of S-adenosyl-L-methionine to synthesize one equivalent of lipoic acid."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/15157071/""}, {""id"": ""PMID:15740115"", ""source_sha256"": ""47015d23a8fc45f71d702a6e14814045ff4301c9a0bc8c1bbe2906406a12d735"", ""source_version"": ""2005; primary indexed abstract inspected via Europe PMC core JSON, not full article; digest covers retained response"", ""title"": ""Mechanistic investigations of lipoic acid biosynthesis in Escherichia coli: both sulfur atoms in lipoic acid are contributed by the same lipoyl synthase polypeptide."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/15740115/""}, {""id"": ""UniProtKB:P60716"", ""source_sha256"": ""c50683fac74d9e13ccfb51dd3e8b5c8e5e80752e3efa3287a921b27561473905"", ""source_version"": ""UniProt 2026_03; full current entry retrieved 2026-10-11 UTC"", ""title"": ""Lipoyl synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60716.json""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-020_aa4721907862	UniProtKB:P60716	BFO:0000050	MetaCyc:CPLX0-782	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-782|MetaCyc:EG11306-MONOMER|UniProtKB:P60716	Two subunits in this native dimer. The record retains the source assembly without rejecting the monomer alternative.	"[{""reference_id"": ""MetaCyc:CPLX0-782"", ""source_assertion"": ""CPLX0-782 contains two copies of EG11306-MONOMER."", ""source_locator"": ""Protein[@frameid=\""CPLX0-782\""]/component/Protein; component/coefficient""}, {""reference_id"": ""MetaCyc:EG11306-MONOMER"", ""source_assertion"": ""EG11306-MONOMER has explicit UNIPROT P60716 unification and MG1655 native taxonomy."", ""source_locator"": ""Protein[@frameid=\""EG11306-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]; species/Organism""}, {""reference_id"": ""UniProtKB:P60716"", ""source_assertion"": ""SUBUNIT states monomer or homodimer without an explicit evidence code; it does not establish a uniquely required oligomer."", ""source_locator"": ""/comments/5""}]"	"[{""id"": ""MetaCyc:CPLX0-782"", ""source_sha256"": ""c518f4e6a9c35e933d20bea27eee5c9f8c07bb0165d81b8383f0e9e2b25f8e0f"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""lipoyl synthase native dimer"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-782""}, {""id"": ""MetaCyc:EG11306-MONOMER"", ""source_sha256"": ""9c6f8441af500be9320be4a4c7c579157f8ebf3f37853a8c8e8025dc8080b634"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""LipA native subunit"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:EG11306-MONOMER""}, {""id"": ""UniProtKB:P60716"", ""source_sha256"": ""c50683fac74d9e13ccfb51dd3e8b5c8e5e80752e3efa3287a921b27561473905"", ""source_version"": ""UniProt 2026_03; full current entry retrieved 2026-10-11 UTC"", ""title"": ""Lipoyl synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60716.json""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-021_745737485719	UniProtKB:P60716	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:15362861|UniProtKB:P60716	CHEBI:49883 denotes the cluster class, not a fixed oxidation state. Rhea whole-carrier nodes separately retain the formal cluster states used in the reaction equation.	"[{""reference_id"": ""UniProtKB:P60716"", ""source_assertion"": ""COFACTOR assigns CHEBI:49883 and two [4Fe-4S] clusters per subunit, with HAMAP ECO:0000255 and experimental ECO:0000269 PMID:15362861."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}, {""reference_id"": ""PMID:15362861"", ""source_assertion"": ""E. coli LipA accommodates two distinct [4Fe-4S] clusters per polypeptide. Mutational and spectroscopic experiments distinguish the two cysteine-binding motifs and their requirement for turnover."", ""source_locator"": ""/resultList/result[id=\""15362861\""]/abstractText""}]"	"[{""id"": ""PMID:15362861"", ""source_sha256"": ""a67a361c544956852f079e4ed3471c9ebce25db4cc65002efe94d2cdf090da3c"", ""source_version"": ""2004; primary indexed abstract inspected via Europe PMC core JSON, not full article; digest covers retained response"", ""title"": ""Escherichia coli lipoyl synthase binds two distinct [4Fe-4S] clusters per polypeptide."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/15362861/""}, {""id"": ""UniProtKB:P60716"", ""source_sha256"": ""c50683fac74d9e13ccfb51dd3e8b5c8e5e80752e3efa3287a921b27561473905"", ""source_version"": ""UniProt 2026_03; full current entry retrieved 2026-10-11 UTC"", ""title"": ""Lipoyl synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60716.json""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-022_6e5005799c04	UniProtKB:P60720	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P60720		"[{""reference_id"": ""UniProtKB:P60720"", ""source_assertion"": ""SUBCELLULAR LOCATION annotates cytoplasm via HAMAP MF_00013, ECO:0000255; this is inferred localization, not an inspected fractionation experiment."", ""source_locator"": ""/comments/5/subcellularLocations""}]"	"[{""id"": ""UniProtKB:P60720"", ""source_sha256"": ""ad34e89fdedc2381f53895fbb1f7c2eaee6a3ca20e1899f97eab0a5bdc3012ca"", ""source_version"": ""UniProt 2026_03; full current entry retrieved 2026-10-11 UTC"", ""title"": ""Octanoyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60720.json""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-023_ac69b96361ce	UniProtKB:P60716	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P60716		"[{""reference_id"": ""UniProtKB:P60716"", ""source_assertion"": ""SUBCELLULAR LOCATION annotates cytoplasm via HAMAP MF_00206, ECO:0000255; this is inferred localization, not an inspected fractionation experiment."", ""source_locator"": ""/comments/6/subcellularLocations""}]"	"[{""id"": ""UniProtKB:P60716"", ""source_sha256"": ""c50683fac74d9e13ccfb51dd3e8b5c8e5e80752e3efa3287a921b27561473905"", ""source_version"": ""UniProt 2026_03; full current entry retrieved 2026-10-11 UTC"", ""title"": ""Lipoyl synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P60716.json""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-024_d27bfce1141c	RHEA:17666	BFO:0000050	MetaCyc:PWY0-501	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-501|MetaCyc:RXN0-947		"[{""reference_id"": ""MetaCyc:PWY0-501"", ""source_assertion"": ""PWY0-501 explicitly lists RXN0-947 and selects its L2R layout. The pathway has exactly two reaction-list members."", ""source_locator"": ""Pathway[@frameid=\""PWY0-501\""]/reaction-list; reaction-layout""}, {""reference_id"": ""MetaCyc:RXN0-947"", ""source_assertion"": ""RXN0-947 explicitly unifies RHEA:17666."", ""source_locator"": ""Reaction[@frameid=\""RXN0-947\""]/dblink[dblink-db=\""RHEA\""]""}]"	"[{""id"": ""MetaCyc:PWY0-501"", ""source_sha256"": ""a94cb0070944764fa0d8140597ce9c8f9cfa2bd4667772ed95d47e1dfa18343b"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""lipoate biosynthesis and incorporation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-501""}, {""id"": ""MetaCyc:RXN0-947"", ""source_sha256"": ""5771ba18461be457ae5d89f0ef60e651c2fc7a49a4b94c9baaae88fcfe6ebd7b"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""octanoyl transfer"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-947""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-025_cf9b07e46660	RHEA:16586	BFO:0000050	MetaCyc:PWY0-501	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-501|MetaCyc:RXN0-949		"[{""reference_id"": ""MetaCyc:PWY0-501"", ""source_assertion"": ""PWY0-501 explicitly lists RXN0-949 and selects its L2R layout. The pathway has exactly two reaction-list members."", ""source_locator"": ""Pathway[@frameid=\""PWY0-501\""]/reaction-list; reaction-layout""}, {""reference_id"": ""MetaCyc:RXN0-949"", ""source_assertion"": ""RXN0-949 explicitly unifies RHEA:16586. For LipA this is a route/core-chemistry bridge; versioned formal redox differences remain documented."", ""source_locator"": ""Reaction[@frameid=\""RXN0-949\""]/dblink[dblink-db=\""RHEA\""]""}]"	"[{""id"": ""MetaCyc:PWY0-501"", ""source_sha256"": ""a94cb0070944764fa0d8140597ce9c8f9cfa2bd4667772ed95d47e1dfa18343b"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""lipoate biosynthesis and incorporation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-501""}, {""id"": ""MetaCyc:RXN0-949"", ""source_sha256"": ""6cf86334548c16e9c79ce3baac56d57b97826812a1f9c450b4bcb289df1ee383"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""lipoyl synthase reaction; native redox convention"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-949""}]"	""
pathwaymech:MetaCyc_PWY0-501_lipoate-edge-026_08724d77b510	RHEA:17666	RO:0002413	RHEA:16586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-501|RHEA:17666	The route is assembly on the target protein. Neither free lipoate synthesis nor LplA-dependent salvage is appended.	"[{""reference_id"": ""MetaCyc:PWY0-501"", ""source_assertion"": ""RXN0-949 explicitly follows RXN0-947; both layouts share Octanoylated-domains."", ""source_locator"": ""Pathway[@frameid=\""PWY0-501\""]/reaction-ordering; reaction-layout""}, {""reference_id"": ""RHEA:17666"", ""source_assertion"": ""The LipB product whole state RHEA-COMP:9928 is the identical octanoyl-protein state consumed by RHEA:16586."", ""source_locator"": ""http://rdf.rhea-db.org/17665_R rh:contains1; http://rdf.rhea-db.org/16585_L rh:contains1; rh:compound http://rdf.rhea-db.org/Compound_9928""}]"	"[{""id"": ""MetaCyc:PWY0-501"", ""source_sha256"": ""a94cb0070944764fa0d8140597ce9c8f9cfa2bd4667772ed95d47e1dfa18343b"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""lipoate biosynthesis and incorporation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-501""}, {""id"": ""RHEA:17666"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; exact triples identified in edge locators"", ""title"": ""Rhea directional reaction 17666"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-001_712cd095b2ea	gomodel:YeastPathways_PWY3O-1743/6a4c244800000448	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1743/6a4c244800000448 RO:0002234 gomodel:YeastPathways_PWY3O-1743/6a4c244800000451."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/0; endpoint types: /individuals/24/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-002_b1439b9245c5	gomodel:YeastPathways_PWY3O-1743/6a4c244800000448	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1743/6a4c244800000448 RO:0002234 gomodel:YeastPathways_PWY3O-1743/6a4c244800000452."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/1; endpoint types: /individuals/24/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-003_3f19836f935e	gomodel:RXN3O-9791	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9791 RO:0002233 gomodel:CHEBI_30616_RXN3O-9791."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/2; endpoint types: /individuals/7/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-004_fcf465919ba0	gomodel:MANNPISOM-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:MANNPISOM-RXN BFO:0000066 gomodel:reaction_MANNPISOM-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/3; endpoint types: /individuals/6/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-005_687775256892	gomodel:YeastPathways_PWY3O-1743/6a4c244800000457	RO:0002234	CHEBI:48066	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1743/6a4c244800000457 RO:0002234 gomodel:CHEBI_48066_RXN3O-9791."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/4; endpoint types: /individuals/31/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-006_4ee4de430426	gomodel:MANNPISOM-RXN	RO:0002234	CHEBI:57634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:MANNPISOM-RXN RO:0002234 gomodel:CHEBI_57634_MANNPISOM-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/5; endpoint types: /individuals/6/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-007_e2c57dbe425f	gomodel:RXN3O-9791	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9791 RO:0002234 gomodel:CHEBI_15378_RXN3O-9791."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/6; endpoint types: /individuals/7/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-008_30050a7bc39e	gomodel:YeastPathways_PWY3O-1743/6a4c244800000448	RO:0002233	CHEBI:4208	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1743/6a4c244800000448 RO:0002233 gomodel:YeastPathways_PWY3O-1743/6a4c244800000450."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/7; endpoint types: /individuals/24/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-009_2f52543b50a7	SGD:S000000545	pathwaymech:enables	gomodel:RXN3O-9791	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9791 RO:0002333 gomodel:YCL040W-MONOMER_RXN3O-9791_controller."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/8; endpoint types: /individuals/7/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-010_f7f1ee9510df	gomodel:RXN3O-9791	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9791 BFO:0000066 gomodel:reaction_RXN3O-9791_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/9; endpoint types: /individuals/7/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-011_6f82f5023026	gomodel:YeastPathways_PWY3O-1743/6a4c244800000457	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1743/6a4c244800000457 RO:0002233 gomodel:YeastPathways_PWY3O-1743/6a4c244800000459."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/10; endpoint types: /individuals/31/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-012_75de840fabee	gomodel:MANNPISOM-RXN	BFO:0000050	GO:0019309	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:MANNPISOM-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-1743/YeastPathways_PWY3O-1743."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/11; endpoint types: /individuals/6/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-013_f98baa96e3f5	gomodel:YeastPathways_PWY3O-1743/6a4c244800000448	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1743/6a4c244800000448 RO:0002233 gomodel:YeastPathways_PWY3O-1743/6a4c244800000449."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/12; endpoint types: /individuals/24/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-014_0c16f0a8607c	gomodel:RXN3O-9791	RO:0002233	CHEBI:4208	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9791 RO:0002233 gomodel:CHEBI_4208_RXN3O-9791."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/13; endpoint types: /individuals/7/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-015_a21ce0f85b44	gomodel:YeastPathways_PWY3O-1743/6a4c244800000457	RO:0002233	CHEBI:4208	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1743/6a4c244800000457 RO:0002233 gomodel:YeastPathways_PWY3O-1743/6a4c244800000458."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/14; endpoint types: /individuals/31/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-016_d8881fdad05a	gomodel:YeastPathways_PWY3O-1743/6a4c244800000457	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1743/6a4c244800000457 BFO:0000066 gomodel:YeastPathways_PWY3O-1743/6a4c244800000465."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/15; endpoint types: /individuals/31/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-017_8d75c431d4be	gomodel:MANNPISOM-RXN	RO:0002233	CHEBI:48066	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:MANNPISOM-RXN RO:0002233 gomodel:CHEBI_48066_RXN3O-9791."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/16; endpoint types: /individuals/6/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-018_2ff9ec9f4b85	gomodel:YeastPathways_PWY3O-1743/6a4c244800000448	RO:0002234	CHEBI:48066	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1743/6a4c244800000448 RO:0002234 gomodel:CHEBI_48066_RXN3O-9791."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/17; endpoint types: /individuals/24/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-019_aae1d3ea39fc	gomodel:YeastPathways_PWY3O-1743/6a4c244800000457	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1743/6a4c244800000457 RO:0002234 gomodel:YeastPathways_PWY3O-1743/6a4c244800000461."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/18; endpoint types: /individuals/31/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-020_fb85d45b08af	gomodel:YeastPathways_PWY3O-1743/6a4c244800000457	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1743/6a4c244800000457 RO:0002234 gomodel:YeastPathways_PWY3O-1743/6a4c244800000460."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/19; endpoint types: /individuals/31/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-021_4816aa5b5ba3	gomodel:RXN3O-9791	BFO:0000050	GO:0019309	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9791 BFO:0000050 gomodel:YeastPathways_PWY3O-1743/YeastPathways_PWY3O-1743."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/20; endpoint types: /individuals/7/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-022_2d51d988e3bb	SGD:S000000805	pathwaymech:enables	gomodel:MANNPISOM-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:MANNPISOM-RXN RO:0002333 gomodel:YER003C-MONOMER_MANNPISOM-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/21; endpoint types: /individuals/6/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-023_84a2b86256d2	SGD:S000001949	pathwaymech:enables	gomodel:YeastPathways_PWY3O-1743/6a4c244800000448	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1743/6a4c244800000448 RO:0002333 gomodel:YeastPathways_PWY3O-1743/6a4c244800000453."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/22; endpoint types: /individuals/24/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-024_394000a4245d	gomodel:YeastPathways_PWY3O-1743/6a4c244800000457	BFO:0000050	GO:0019309	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1743/6a4c244800000457 BFO:0000050 gomodel:YeastPathways_PWY3O-1743/YeastPathways_PWY3O-1743."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/23; endpoint types: /individuals/31/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-025_101b76ef4df0	gomodel:RXN3O-9791	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9791 RO:0002234 gomodel:CHEBI_456216_RXN3O-9791."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/24; endpoint types: /individuals/7/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-026_eb28222fb568	gomodel:RXN3O-9791	RO:0002234	CHEBI:48066	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9791 RO:0002234 gomodel:CHEBI_48066_RXN3O-9791."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/25; endpoint types: /individuals/7/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-027_273baf647b60	SGD:S000003222	pathwaymech:enables	gomodel:YeastPathways_PWY3O-1743/6a4c244800000457	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1743/6a4c244800000457 RO:0002333 gomodel:YeastPathways_PWY3O-1743/6a4c244800000462."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/26; endpoint types: /individuals/31/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-028_786266e6bb8a	gomodel:YeastPathways_PWY3O-1743/6a4c244800000448	BFO:0000050	GO:0019309	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1743/6a4c244800000448 BFO:0000050 gomodel:YeastPathways_PWY3O-1743/YeastPathways_PWY3O-1743."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/27; endpoint types: /individuals/24/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_edge-029_64c000724045	gomodel:YeastPathways_PWY3O-1743/6a4c244800000448	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1743		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-1743/6a4c244800000448 BFO:0000066 gomodel:YeastPathways_PWY3O-1743/6a4c244800000456."", ""source_locator"": ""./YeastPathways_PWY3O-1743.json#/facts/28; endpoint types: /individuals/24/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1743"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-1743.json"", ""title"": ""SGD GO-CAM mannose degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_location-b0affdb6241d_7d91f00c8b7f	SGD:S000000805	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P29952	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P29952"", ""source_assertion"": ""UniProtKB:P29952 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/822/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P29952"", ""source_assertion"": ""UniProtKB:P29952 has the exact SGD cross-reference SGD:S000000805."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/822/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P29952"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P29952 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1743_cofactor-37cbae61fe33_09e1d20cec2a	SGD:S000000805	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P29952	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified Binds 1 zinc ion per subunit.	"[{""reference_id"": ""UniProtKB:P29952"", ""source_assertion"": ""UniProtKB:P29952 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/822/comments/0/cofactors/0; /results/822/comments/0/note""}, {""reference_id"": ""UniProtKB:P29952"", ""source_assertion"": ""UniProtKB:P29952 has the exact SGD cross-reference SGD:S000000805."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/822/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P29952"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P29952 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-001_1ca60d34ebe4	gomodel:R147-RXN	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R147-RXN RO:0002233 gomodel:CHEBI_15379_R147-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/0; endpoint types: /individuals/23/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-002_54e23a80b300	gomodel:YeastPathways_PWY3O-64/6a4c244800001410	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001410 BFO:0000066 gomodel:YeastPathways_PWY3O-64/6a4c244800001417."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/1; endpoint types: /individuals/84/type; /individuals/89/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-003_29d1bcfe457a	gomodel:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN	RO:0002234	CHEBI:16708	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN RO:0002234 gomodel:CHEBI_16708_5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/2; endpoint types: /individuals/67/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-004_02e6b219b5fb	gomodel:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN	BFO:0000050	GO:0071267	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-64/YeastPathways_PWY3O-64."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/3; endpoint types: /individuals/67/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-005_4fdc14bd0d29	gomodel:R147-RXN	RO:0002234	CHEBI:16723	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R147-RXN RO:0002234 gomodel:CHEBI_16723_R147-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/4; endpoint types: /individuals/23/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-006_9f936d46c3d1	gomodel:R15-RXN	RO:0002233	CHEBI:16723	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R15-RXN RO:0002233 gomodel:CHEBI_16723_R147-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/5; endpoint types: /individuals/24/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-007_08fd5a6265d8	gomodel:3.1.3.77-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:3.1.3.77-RXN RO:0002234 gomodel:CHEBI_15378_3.1.3.77-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/6; endpoint types: /individuals/66/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-008_d6ab5bbcef16	gomodel:R147-RXN	BFO:0000050	GO:0071267	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R147-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-64/YeastPathways_PWY3O-64."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/7; endpoint types: /individuals/23/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-009_5c39e916a49d	gomodel:YeastPathways_PWY3O-64/6a4c244800001425	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001425 BFO:0000066 gomodel:YeastPathways_PWY3O-64/6a4c244800001431."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/8; endpoint types: /individuals/97/type; /individuals/102/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-010_69d5c2e5d5a9	SGD:S000003170	pathwaymech:enables	gomodel:YeastPathways_PWY3O-64/6a4c244800001410	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001410 RO:0002333 gomodel:YeastPathways_PWY3O-64/6a4c244800001414."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/9; endpoint types: /individuals/84/type; /individuals/88/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-011_161e2a2c0022	gomodel:R15-RXN	RO:0002234	CHEBI:35910	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R15-RXN RO:0002234 gomodel:CHEBI_35910_R15-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/10; endpoint types: /individuals/24/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-012_3c07c71380bb	gomodel:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN	RO:0002233	CHEBI:17509	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN RO:0002233 gomodel:CHEBI_17509_5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/11; endpoint types: /individuals/67/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-013_5a90aac056f0	gomodel:YeastPathways_PWY3O-64/6a4c244800001410	RO:0002234	CHEBI:57844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001410 RO:0002234 gomodel:YeastPathways_PWY3O-64/6a4c244800001413."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/12; endpoint types: /individuals/84/type; /individuals/87/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-014_9b6caa22f78b	gomodel:YeastPathways_PWY3O-64/6a4c244800001394	RO:0002233	CHEBI:83813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001394 RO:0002233 gomodel:YeastPathways_PWY3O-64/6a4c244800001395."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/13; endpoint types: /individuals/71/type; /individuals/72/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-015_f4971dea6929	gomodel:YeastPathways_PWY3O-64/6a4c244800001410	RO:0002234	CHEBI:35910	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001410 RO:0002234 gomodel:YeastPathways_PWY3O-64/6a4c244800001412."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/14; endpoint types: /individuals/84/type; /individuals/86/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-016_fb5f71110cf3	gomodel:R147-RXN	RO:0002234	CHEBI:15740	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R147-RXN RO:0002234 gomodel:CHEBI_15740_R147-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/15; endpoint types: /individuals/23/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-017_02bce6edce13	SGD:S000004007	pathwaymech:enables	gomodel:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN RO:0002333 gomodel:MONOMER3O-157_5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/16; endpoint types: /individuals/67/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-018_06e9f90c2963	gomodel:YeastPathways_PWY3O-64/6a4c244800001425	RO:0002234	CHEBI:57844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001425 RO:0002234 gomodel:YeastPathways_PWY3O-64/6a4c244800001428."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/17; endpoint types: /individuals/97/type; /individuals/100/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-019_39623fff2a18	gomodel:3.1.3.77-RXN	BFO:0000050	GO:0071267	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:3.1.3.77-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-64/YeastPathways_PWY3O-64."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/18; endpoint types: /individuals/66/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-020_c9ea6808aa9b	gomodel:YeastPathways_PWY3O-64/6a4c244800001425	RO:0002233	CHEBI:83813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001425 RO:0002233 gomodel:YeastPathways_PWY3O-64/6a4c244800001426."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/19; endpoint types: /individuals/97/type; /individuals/98/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-021_8d7303d62bca	gomodel:3.1.3.77-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:3.1.3.77-RXN BFO:0000066 gomodel:reaction_3.1.3.77-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/20; endpoint types: /individuals/66/type; /individuals/60/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-022_673d3be05646	gomodel:R145-RXN	RO:0002233	CHEBI:58548	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R145-RXN RO:0002233 gomodel:CHEBI_58548_5.3.1.23-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/21; endpoint types: /individuals/22/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-023_94c2267cb632	gomodel:R147-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R147-RXN BFO:0000066 gomodel:reaction_R147-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/22; endpoint types: /individuals/23/type; /individuals/64/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-024_39078f2f3078	gomodel:R145-RXN	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R145-RXN RO:0002234 gomodel:CHEBI_15377_R145-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/23; endpoint types: /individuals/22/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-025_274a3622fd83	gomodel:YeastPathways_PWY3O-64/6a4c244800001410	BFO:0000050	GO:0071267	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001410 BFO:0000050 gomodel:YeastPathways_PWY3O-64/YeastPathways_PWY3O-64."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/24; endpoint types: /individuals/84/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-026_c5b8ca119111	gomodel:YeastPathways_PWY3O-64/6a4c244800001425	RO:0002233	CHEBI:16723	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001425 RO:0002233 gomodel:CHEBI_16723_R147-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/25; endpoint types: /individuals/97/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-027_f84a269d8ded	gomodel:R145-RXN	BFO:0000050	GO:0071267	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R145-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-64/YeastPathways_PWY3O-64."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/26; endpoint types: /individuals/22/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-028_187ce008fdb2	gomodel:R15-RXN	RO:0002234	CHEBI:57844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R15-RXN RO:0002234 gomodel:CHEBI_57844_R15-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/27; endpoint types: /individuals/24/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-029_c1671eb9e508	gomodel:YeastPathways_PWY3O-64/6a4c244800001410	RO:0002233	CHEBI:16723	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001410 RO:0002233 gomodel:CHEBI_16723_R147-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/28; endpoint types: /individuals/84/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-030_ed3e67bf4499	gomodel:3.1.3.77-RXN	RO:0002233	CHEBI:58828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:3.1.3.77-RXN RO:0002233 gomodel:CHEBI_58828_R145-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/29; endpoint types: /individuals/66/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-031_97223e573ab8	gomodel:R15-RXN	RO:0002233	CHEBI:83813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R15-RXN RO:0002233 gomodel:CHEBI_83813_R15-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/30; endpoint types: /individuals/24/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-032_fe5b0032f205	SGD:S000003785	pathwaymech:enables	gomodel:R145-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R145-RXN RO:0002333 gomodel:MONOMER3O-169_R145-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/31; endpoint types: /individuals/22/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-033_14df831a90f7	gomodel:R147-RXN	RO:0002233	CHEBI:58795	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R147-RXN RO:0002233 gomodel:CHEBI_58795_3.1.3.77-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/32; endpoint types: /individuals/23/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-034_88131d8d2486	SGD:S000006322	pathwaymech:enables	gomodel:5.3.1.23-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:5.3.1.23-RXN RO:0002333 gomodel:YeastPathways_PWY3O-64/6690711d00000278."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/33; endpoint types: /individuals/68/type; /individuals/110/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-036_ca282ecdfbb0	gomodel:5.3.1.23-RXN	RO:0002234	CHEBI:58548	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:5.3.1.23-RXN RO:0002234 gomodel:CHEBI_58548_5.3.1.23-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/35; endpoint types: /individuals/68/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-037_4a5d56115543	gomodel:R145-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R145-RXN BFO:0000066 gomodel:reaction_R145-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/36; endpoint types: /individuals/22/type; /individuals/63/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-038_5b11cd9e4c08	gomodel:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN	RO:0002234	CHEBI:58533	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN RO:0002234 gomodel:CHEBI_58533_5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/37; endpoint types: /individuals/67/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-039_5d28f7e1b9df	gomodel:3.1.3.77-RXN	RO:0002234	CHEBI:58795	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:3.1.3.77-RXN RO:0002234 gomodel:CHEBI_58795_3.1.3.77-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/38; endpoint types: /individuals/66/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-040_ced2be61073a	gomodel:YeastPathways_PWY3O-64/6a4c244800001394	RO:0002234	CHEBI:57844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001394 RO:0002234 gomodel:YeastPathways_PWY3O-64/6a4c244800001396."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/39; endpoint types: /individuals/71/type; /individuals/73/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-041_597cc7980197	gomodel:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN	RO:0002233	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN RO:0002233 gomodel:CHEBI_43474_5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/40; endpoint types: /individuals/67/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-042_3c8751a74dca	gomodel:5.3.1.23-RXN	RO:0002233	CHEBI:58533	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:5.3.1.23-RXN RO:0002233 gomodel:CHEBI_58533_5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/41; endpoint types: /individuals/68/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-043_e8922ecaa3ad	gomodel:YeastPathways_PWY3O-64/6a4c244800001394	RO:0002233	CHEBI:16723	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001394 RO:0002233 gomodel:CHEBI_16723_R147-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/42; endpoint types: /individuals/71/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-044_9c78e275f131	SGD:S000001251	pathwaymech:enables	gomodel:R15-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R15-RXN RO:0002333 gomodel:YHR208W-MONOMER_R15-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/43; endpoint types: /individuals/24/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-045_4b08803540b5	gomodel:YeastPathways_PWY3O-64/6a4c244800001394	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001394 BFO:0000066 gomodel:YeastPathways_PWY3O-64/6a4c244800001402."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/44; endpoint types: /individuals/71/type; /individuals/76/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-046_9aeb7d391990	gomodel:YeastPathways_PWY3O-64/6a4c244800001425	RO:0002234	CHEBI:35910	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001425 RO:0002234 gomodel:YeastPathways_PWY3O-64/6a4c244800001427."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/45; endpoint types: /individuals/97/type; /individuals/99/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-047_4bdec186fcba	gomodel:3.1.3.77-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:3.1.3.77-RXN RO:0002233 gomodel:CHEBI_15377_3.1.3.77-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/46; endpoint types: /individuals/66/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-048_bd9e4bd87ec5	SGD:S000000764	pathwaymech:enables	gomodel:3.1.3.77-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:3.1.3.77-RXN RO:0002333 gomodel:MONOMER3O-175_3.1.3.77-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/47; endpoint types: /individuals/66/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-049_761035837ff3	gomodel:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN BFO:0000066 gomodel:reaction_5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/48; endpoint types: /individuals/67/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-050_a08af018e784	gomodel:R145-RXN	RO:0002234	CHEBI:58828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R145-RXN RO:0002234 gomodel:CHEBI_58828_R145-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/49; endpoint types: /individuals/22/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-051_4d9ec161daa5	SGD:S000003909	pathwaymech:enables	gomodel:YeastPathways_PWY3O-64/6a4c244800001394	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001394 RO:0002333 gomodel:YeastPathways_PWY3O-64/6a4c244800001401."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/50; endpoint types: /individuals/71/type; /individuals/75/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-052_b91b656e8383	gomodel:5.3.1.23-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:5.3.1.23-RXN BFO:0000066 gomodel:reaction_5.3.1.23-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/51; endpoint types: /individuals/68/type; /individuals/62/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-053_366e4fa756b8	gomodel:R15-RXN	BFO:0000050	GO:0071267	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R15-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-64/YeastPathways_PWY3O-64."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/52; endpoint types: /individuals/24/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-054_4c6acbac4462	gomodel:YeastPathways_PWY3O-64/6a4c244800001425	BFO:0000050	GO:0071267	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001425 BFO:0000050 gomodel:YeastPathways_PWY3O-64/YeastPathways_PWY3O-64."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/53; endpoint types: /individuals/97/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-055_62133969bb33	gomodel:5.3.1.23-RXN	BFO:0000050	GO:0071267	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:5.3.1.23-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-64/YeastPathways_PWY3O-64."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/54; endpoint types: /individuals/68/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-056_9b0ad4e8a5af	gomodel:R147-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R147-RXN RO:0002234 gomodel:CHEBI_15378_R147-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/55; endpoint types: /individuals/23/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-057_9f10769aa3b2	gomodel:3.1.3.77-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:3.1.3.77-RXN RO:0002234 gomodel:CHEBI_43474_3.1.3.77-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/56; endpoint types: /individuals/66/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-058_0dc7b71d0ff7	SGD:S000001179	pathwaymech:enables	gomodel:YeastPathways_PWY3O-64/6a4c244800001425	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001425 RO:0002333 gomodel:YeastPathways_PWY3O-64/6a4c244800001430."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/57; endpoint types: /individuals/97/type; /individuals/101/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-059_4916d7750fcc	SGD:S000004611	pathwaymech:enables	gomodel:R147-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:R147-RXN RO:0002333 gomodel:MONOMER3O-186_R147-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/58; endpoint types: /individuals/23/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-060_f7908e08bb12	gomodel:YeastPathways_PWY3O-64/6a4c244800001394	BFO:0000050	GO:0071267	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001394 BFO:0000050 gomodel:YeastPathways_PWY3O-64/YeastPathways_PWY3O-64."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/59; endpoint types: /individuals/71/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-061_da153ac12074	gomodel:YeastPathways_PWY3O-64/6a4c244800001394	RO:0002234	CHEBI:35910	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001394 RO:0002234 gomodel:YeastPathways_PWY3O-64/6a4c244800001397."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/60; endpoint types: /individuals/71/type; /individuals/74/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_edge-062_30c0c0a3c033	gomodel:YeastPathways_PWY3O-64/6a4c244800001410	RO:0002233	CHEBI:83813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-64		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-64/6a4c244800001410 RO:0002233 gomodel:YeastPathways_PWY3O-64/6a4c244800001411."", ""source_locator"": ""./YeastPathways_PWY3O-64.json#/facts/61; endpoint types: /individuals/84/type; /individuals/85/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-64"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-64.json"", ""title"": ""SGD GO-CAM methionine salvage pathway - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_location-ad4354e8d3df_74cb64334461	SGD:S000003170	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53090	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2112/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 has the exact SGD cross-reference SGD:S000003170."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2112/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53090"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53090 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_location-d5d5362a8cec_bd1b8085d4f2	SGD:S000004007	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q07938	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:Q07938"", ""source_assertion"": ""UniProtKB:Q07938 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2845/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q07938"", ""source_assertion"": ""UniProtKB:Q07938 has the exact SGD cross-reference SGD:S000004007."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2845/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q07938"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q07938 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_location-ca636a54a937_c22d58a14a33	SGD:S000004007	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q07938	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:Q07938"", ""source_assertion"": ""UniProtKB:Q07938 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2845/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q07938"", ""source_assertion"": ""UniProtKB:Q07938 has the exact SGD cross-reference SGD:S000004007."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2845/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q07938"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q07938 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_location-9aa1acbccbd3_dc89ee712005	SGD:S000003785	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47095	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03116); ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P47095"", ""source_assertion"": ""UniProtKB:P47095 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3872/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P47095"", ""source_assertion"": ""UniProtKB:P47095 has the exact SGD cross-reference SGD:S000003785."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3872/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P47095"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47095 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_location-bc2402c10581_2ee4739505b7	SGD:S000006322	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06489	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03119); ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q06489"", ""source_assertion"": ""UniProtKB:Q06489 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4195/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q06489"", ""source_assertion"": ""UniProtKB:Q06489 has the exact SGD cross-reference SGD:S000006322."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4195/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q06489"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06489 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_location-0beff1ff9b41_785583054361	SGD:S000006322	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06489	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03119); ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q06489"", ""source_assertion"": ""UniProtKB:Q06489 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4195/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q06489"", ""source_assertion"": ""UniProtKB:Q06489 has the exact SGD cross-reference SGD:S000006322."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4195/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q06489"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06489 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_location-f9bd1202481b_b98af13cf4e4	SGD:S000001251	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38891	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:21267457); ECO:0000269 (PubMed:8798704)	"[{""reference_id"": ""UniProtKB:P38891"", ""source_assertion"": ""UniProtKB:P38891 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1497/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38891"", ""source_assertion"": ""UniProtKB:P38891 has the exact SGD cross-reference SGD:S000001251."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1497/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38891"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38891 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_location-f014a6b9d817_bc8efaa7ef5a	SGD:S000000764	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32626	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03117); ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P32626"", ""source_assertion"": ""UniProtKB:P32626 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3436/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32626"", ""source_assertion"": ""UniProtKB:P32626 has the exact SGD cross-reference SGD:S000000764."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3436/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32626"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32626 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_location-6ff8c461ffb0_1b4e6b61e11a	SGD:S000000764	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32626	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03117); ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P32626"", ""source_assertion"": ""UniProtKB:P32626 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3436/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32626"", ""source_assertion"": ""UniProtKB:P32626 has the exact SGD cross-reference SGD:S000000764."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3436/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32626"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32626 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_location-5a706de09f76_4a3466d9214b	SGD:S000003909	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47176	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:21267457); ECO:0000269 (PubMed:8798704)	"[{""reference_id"": ""UniProtKB:P47176"", ""source_assertion"": ""UniProtKB:P47176 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1987/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P47176"", ""source_assertion"": ""UniProtKB:P47176 has the exact SGD cross-reference SGD:S000003909."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1987/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P47176"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47176 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_location-21257d2833bc_d6ffc3faf850	SGD:S000001179	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38840	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1469/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 has the exact SGD cross-reference SGD:S000001179."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1469/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38840"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38840 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_location-0b714ee735cc_0d328f84aeae	SGD:S000004611	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q03677	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:Q03677"", ""source_assertion"": ""UniProtKB:Q03677 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2528/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q03677"", ""source_assertion"": ""UniProtKB:Q03677 has the exact SGD cross-reference SGD:S000004611."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2528/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q03677"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q03677 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_location-67b5d491adc1_4cfb4b51ec24	SGD:S000004611	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q03677	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:Q03677"", ""source_assertion"": ""UniProtKB:Q03677 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2528/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q03677"", ""source_assertion"": ""UniProtKB:Q03677 has the exact SGD cross-reference SGD:S000004611."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2528/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q03677"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q03677 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_cofactor-46a0dec0bfb8_5db4c929e32b	SGD:S000003170	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53090	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:23893908)	"[{""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 has the exact SGD cross-reference SGD:S000003170."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53090"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53090 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_cofactor-e17b4a8c33d3_7013e814cdc5	SGD:S000003785	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47095	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03116) Binds 1 zinc ion per subunit. UniProt note evidence: ECO:0000255 (HAMAP-Rule:MF_03116)	"[{""reference_id"": ""UniProtKB:P47095"", ""source_assertion"": ""UniProtKB:P47095 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3872/comments/0/cofactors/0; /results/3872/comments/0/note""}, {""reference_id"": ""UniProtKB:P47095"", ""source_assertion"": ""UniProtKB:P47095 has the exact SGD cross-reference SGD:S000003785."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3872/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P47095"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47095 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_cofactor-2ed218c0aed2_9e2fd494945c	SGD:S000001251	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38891	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: Disputed growth phenotypes do not address PLP binding; retain the similarity-based PLP annotation. UniProt evidence: ECO:0000250 (UniProtKB:P0AB80)	"[{""reference_id"": ""UniProtKB:P38891"", ""source_assertion"": ""UniProtKB:P38891 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1497/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P38891"", ""source_assertion"": ""UniProtKB:P38891 has the exact SGD cross-reference SGD:S000001251."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1497/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38891"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38891 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_cofactor-3d9f00edd8b4_5bc57060f1fc	SGD:S000000764	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32626	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified Binds 1 Mg(2+) ion per subunit.	"[{""reference_id"": ""UniProtKB:P32626"", ""source_assertion"": ""UniProtKB:P32626 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3436/comments/0/cofactors/0; /results/3436/comments/0/note""}, {""reference_id"": ""UniProtKB:P32626"", ""source_assertion"": ""UniProtKB:P32626 has the exact SGD cross-reference SGD:S000000764."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3436/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32626"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32626 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_cofactor-41b7855c2473_d3943c729cbf	SGD:S000003909	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47176	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P47176"", ""source_assertion"": ""UniProtKB:P47176 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1987/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P47176"", ""source_assertion"": ""UniProtKB:P47176 has the exact SGD cross-reference SGD:S000003909."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1987/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P47176"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47176 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_cofactor-eb2a9050a8eb_38c89459c1ec	SGD:S000001179	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38840	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:O84395)	"[{""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1469/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 has the exact SGD cross-reference SGD:S000001179."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1469/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38840"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38840 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_cofactor-569fd3802b8c_8e0dd4857e9a	SGD:S000004611	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q03677	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: ADI1 metal identity changes the chemical products. These are alternatives, not simultaneous requirements of one reaction. Iron-bound ADI1 supports the methionine-salvage branch producing 2-keto-4-methylthiobutyrate. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03154) Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate. UniProt note evidence: ECO:0000255 (HAMAP-Rule:MF_03154)	"[{""reference_id"": ""UniProtKB:Q03677"", ""source_assertion"": ""UniProtKB:Q03677 annotates CHEBI:29033 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2528/comments/0/cofactors/0; /results/2528/comments/0/note""}, {""reference_id"": ""UniProtKB:Q03677"", ""source_assertion"": ""UniProtKB:Q03677 has the exact SGD cross-reference SGD:S000004611."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2528/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q03677"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q03677 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-64_cofactor-e00ab4939c85_45f4a7474029	SGD:S000004611	pathwaymech:has_cofactor	CHEBI:49786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q03677	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: ADI1 metal identity changes the chemical products. These are alternatives, not simultaneous requirements of one reaction. Nickel-bound ADI1 supports an alternative branch producing 3-(methylsulfanyl)propanoate; this does not assert nickel is required for the methionine-salvage reaction. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03154) Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate. UniProt note evidence: ECO:0000255 (HAMAP-Rule:MF_03154)	"[{""reference_id"": ""UniProtKB:Q03677"", ""source_assertion"": ""UniProtKB:Q03677 annotates CHEBI:49786 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2528/comments/0/cofactors/1; /results/2528/comments/0/note""}, {""reference_id"": ""UniProtKB:Q03677"", ""source_assertion"": ""UniProtKB:Q03677 has the exact SGD cross-reference SGD:S000004611."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2528/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q03677"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q03677 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-001_a9f1dcf1fa6b	CHEBI:59776	pathwaymech:consumes	RHEA:12606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12606		"[{""reference_id"": ""RHEA:12606"", ""source_assertion"": ""Rhea RHEA:12606 places CHEBI:59776 on its substrates side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12606']/rh:substrates; http://rdf.rhea-db.org/12605_L/rh:contains1; http://rdf.rhea-db.org/Participant_12605_compound_6062/rh:compound; http://rdf.rhea-db.org/Compound_6062/rh:accession""}]"	"[{""id"": ""RHEA:12606"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 12606: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/12606""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-002_877e94cc26d5	CHEBI:15361	pathwaymech:consumes	RHEA:12606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12606		"[{""reference_id"": ""RHEA:12606"", ""source_assertion"": ""Rhea RHEA:12606 places CHEBI:15361 on its substrates side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12606']/rh:substrates; http://rdf.rhea-db.org/12605_L/rh:contains1; http://rdf.rhea-db.org/Participant_12605_compound_3719/rh:compound; http://rdf.rhea-db.org/Compound_3719/rh:accession""}]"	"[{""id"": ""RHEA:12606"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 12606: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/12606""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-003_fff9548257dd	CHEBI:15378	pathwaymech:consumes	RHEA:12606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12606		"[{""reference_id"": ""RHEA:12606"", ""source_assertion"": ""Rhea RHEA:12606 places CHEBI:15378 on its substrates side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12606']/rh:substrates; http://rdf.rhea-db.org/12605_L/rh:contains1; http://rdf.rhea-db.org/Participant_12605_compound_3249/rh:compound; http://rdf.rhea-db.org/Compound_3249/rh:accession""}]"	"[{""id"": ""RHEA:12606"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 12606: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/12606""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-004_d001a2bf8c6a	RHEA:12606	pathwaymech:produces	CHEBI:57792	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12606		"[{""reference_id"": ""RHEA:12606"", ""source_assertion"": ""Rhea RHEA:12606 places CHEBI:57792 on its products side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12606']/rh:products; http://rdf.rhea-db.org/12605_R/rh:contains1; http://rdf.rhea-db.org/Participant_12605_compound_2654/rh:compound; http://rdf.rhea-db.org/Compound_2654/rh:accession""}]"	"[{""id"": ""RHEA:12606"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 12606: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/12606""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-005_c87ed9e89588	RHEA:12606	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12606		"[{""reference_id"": ""RHEA:12606"", ""source_assertion"": ""Rhea RHEA:12606 places CHEBI:16526 on its products side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12606']/rh:products; http://rdf.rhea-db.org/12605_R/rh:contains1; http://rdf.rhea-db.org/Participant_12605_compound_4391/rh:compound; http://rdf.rhea-db.org/Compound_4391/rh:accession""}]"	"[{""id"": ""RHEA:12606"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 12606: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/12606""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-006_c8039cf3d5f2	UniProtKB:P77488	pathwaymech:catalyzes	RHEA:12606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77488		"[{""reference_id"": ""UniProtKB:P77488"", ""source_assertion"": ""UniProt UniProtKB:P77488 assigns catalytic activity to RHEA:12605, the reaction family of RHEA:12606; organism NCBITaxon:83333. Annotation evidence: ECO:0000269."", ""source_locator"": ""results[primaryAccession='P77488'].comments[1].reaction""}]"	"[{""id"": ""UniProtKB:P77488"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB P77488: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77488.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-007_78f92f80772a	CHEBI:57792	pathwaymech:consumes	RHEA:13719	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13719		"[{""reference_id"": ""RHEA:13719"", ""source_assertion"": ""Rhea RHEA:13719 places CHEBI:57792 on its substrates side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13719']/rh:substrates; http://rdf.rhea-db.org/13717_R/rh:contains1; http://rdf.rhea-db.org/Participant_13717_compound_2654/rh:compound; http://rdf.rhea-db.org/Compound_2654/rh:accession""}]"	"[{""id"": ""RHEA:13719"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 13719: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/13719""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-008_52a518b0b00b	CHEBI:57783	pathwaymech:consumes	RHEA:13719	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13719		"[{""reference_id"": ""RHEA:13719"", ""source_assertion"": ""Rhea RHEA:13719 places CHEBI:57783 on its substrates side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13719']/rh:substrates; http://rdf.rhea-db.org/13717_R/rh:contains1; http://rdf.rhea-db.org/Participant_13717_compound_3438/rh:compound; http://rdf.rhea-db.org/Compound_3438/rh:accession""}]"	"[{""id"": ""RHEA:13719"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 13719: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/13719""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-009_bfa9281367c3	CHEBI:15378	pathwaymech:consumes	RHEA:13719	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13719		"[{""reference_id"": ""RHEA:13719"", ""source_assertion"": ""Rhea RHEA:13719 places CHEBI:15378 on its substrates side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13719']/rh:substrates; http://rdf.rhea-db.org/13717_R/rh:contains1; http://rdf.rhea-db.org/Participant_13717_compound_3249/rh:compound; http://rdf.rhea-db.org/Compound_3249/rh:accession""}]"	"[{""id"": ""RHEA:13719"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 13719: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/13719""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-010_043872c4e833	RHEA:13719	pathwaymech:produces	CHEBI:58262	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13719		"[{""reference_id"": ""RHEA:13719"", ""source_assertion"": ""Rhea RHEA:13719 places CHEBI:58262 on its products side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13719']/rh:products; http://rdf.rhea-db.org/13717_L/rh:contains1; http://rdf.rhea-db.org/Participant_13717_compound_3223/rh:compound; http://rdf.rhea-db.org/Compound_3223/rh:accession""}]"	"[{""id"": ""RHEA:13719"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 13719: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/13719""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-011_17e04695f740	RHEA:13719	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13719		"[{""reference_id"": ""RHEA:13719"", ""source_assertion"": ""Rhea RHEA:13719 places CHEBI:58349 on its products side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13719']/rh:products; http://rdf.rhea-db.org/13717_L/rh:contains1; http://rdf.rhea-db.org/Participant_13717_compound_5188/rh:compound; http://rdf.rhea-db.org/Compound_5188/rh:accession""}]"	"[{""id"": ""RHEA:13719"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 13719: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/13719""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-012_12406359771f	UniProtKB:P45568	pathwaymech:catalyzes	RHEA:13719	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P45568		"[{""reference_id"": ""UniProtKB:P45568"", ""source_assertion"": ""UniProt UniProtKB:P45568 assigns catalytic activity to RHEA:13717, the reaction family of RHEA:13719; organism NCBITaxon:83333. Annotation evidence: ECO:0000269."", ""source_locator"": ""results[primaryAccession='P45568'].comments[1].reaction""}]"	"[{""id"": ""UniProtKB:P45568"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB P45568: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/P45568.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-013_29da7a6eda64	CHEBI:58262	pathwaymech:consumes	RHEA:13430	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13430		"[{""reference_id"": ""RHEA:13430"", ""source_assertion"": ""Rhea RHEA:13430 places CHEBI:58262 on its substrates side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13430']/rh:substrates; http://rdf.rhea-db.org/13429_L/rh:contains1; http://rdf.rhea-db.org/Participant_13429_compound_3223/rh:compound; http://rdf.rhea-db.org/Compound_3223/rh:accession""}]"	"[{""id"": ""RHEA:13430"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 13430: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/13430""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-014_860f058b5614	CHEBI:37563	pathwaymech:consumes	RHEA:13430	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13430		"[{""reference_id"": ""RHEA:13430"", ""source_assertion"": ""Rhea RHEA:13430 places CHEBI:37563 on its substrates side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13430']/rh:substrates; http://rdf.rhea-db.org/13429_L/rh:contains1; http://rdf.rhea-db.org/Participant_13429_compound_6434/rh:compound; http://rdf.rhea-db.org/Compound_6434/rh:accession""}]"	"[{""id"": ""RHEA:13430"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 13430: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/13430""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-015_2e97d57d6aeb	CHEBI:15378	pathwaymech:consumes	RHEA:13430	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13430		"[{""reference_id"": ""RHEA:13430"", ""source_assertion"": ""Rhea RHEA:13430 places CHEBI:15378 on its substrates side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13430']/rh:substrates; http://rdf.rhea-db.org/13429_L/rh:contains1; http://rdf.rhea-db.org/Participant_13429_compound_3249/rh:compound; http://rdf.rhea-db.org/Compound_3249/rh:accession""}]"	"[{""id"": ""RHEA:13430"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 13430: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/13430""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-016_3d85ad32957b	RHEA:13430	pathwaymech:produces	CHEBI:57823	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13430		"[{""reference_id"": ""RHEA:13430"", ""source_assertion"": ""Rhea RHEA:13430 places CHEBI:57823 on its products side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13430']/rh:products; http://rdf.rhea-db.org/13429_R/rh:contains1; http://rdf.rhea-db.org/Participant_13429_compound_1305/rh:compound; http://rdf.rhea-db.org/Compound_1305/rh:accession""}]"	"[{""id"": ""RHEA:13430"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 13430: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/13430""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-017_e9b3a8606608	RHEA:13430	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13430		"[{""reference_id"": ""RHEA:13430"", ""source_assertion"": ""Rhea RHEA:13430 places CHEBI:33019 on its products side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13430']/rh:products; http://rdf.rhea-db.org/13429_R/rh:contains1; http://rdf.rhea-db.org/Participant_13429_compound_2106/rh:compound; http://rdf.rhea-db.org/Compound_2106/rh:accession""}]"	"[{""id"": ""RHEA:13430"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 13430: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/13430""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-018_3e5a5b4cc36d	UniProtKB:Q46893	pathwaymech:catalyzes	RHEA:13430	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q46893		"[{""reference_id"": ""UniProtKB:Q46893"", ""source_assertion"": ""UniProt UniProtKB:Q46893 assigns catalytic activity to RHEA:13429, the reaction family of RHEA:13430; organism NCBITaxon:83333. Annotation evidence: no evidence code supplied on this source field."", ""source_locator"": ""results[primaryAccession='Q46893'].comments[1].reaction""}]"	"[{""id"": ""UniProtKB:Q46893"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB Q46893: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q46893.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-019_d5f8e0e99cdf	CHEBI:57823	pathwaymech:consumes	RHEA:18438	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18438		"[{""reference_id"": ""RHEA:18438"", ""source_assertion"": ""Rhea RHEA:18438 places CHEBI:57823 on its substrates side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18438']/rh:substrates; http://rdf.rhea-db.org/18437_L/rh:contains1; http://rdf.rhea-db.org/Participant_18437_compound_1305/rh:compound; http://rdf.rhea-db.org/Compound_1305/rh:accession""}]"	"[{""id"": ""RHEA:18438"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 18438: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/18438""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-020_4dff3e4edd70	CHEBI:30616	pathwaymech:consumes	RHEA:18438	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18438		"[{""reference_id"": ""RHEA:18438"", ""source_assertion"": ""Rhea RHEA:18438 places CHEBI:30616 on its substrates side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18438']/rh:substrates; http://rdf.rhea-db.org/18437_L/rh:contains1; http://rdf.rhea-db.org/Participant_18437_compound_6372/rh:compound; http://rdf.rhea-db.org/Compound_6372/rh:accession""}]"	"[{""id"": ""RHEA:18438"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 18438: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/18438""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-021_b394063ce195	RHEA:18438	pathwaymech:produces	CHEBI:57919	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18438		"[{""reference_id"": ""RHEA:18438"", ""source_assertion"": ""Rhea RHEA:18438 places CHEBI:57919 on its products side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18438']/rh:products; http://rdf.rhea-db.org/18437_R/rh:contains1; http://rdf.rhea-db.org/Participant_18437_compound_1085/rh:compound; http://rdf.rhea-db.org/Compound_1085/rh:accession""}]"	"[{""id"": ""RHEA:18438"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 18438: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/18438""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-022_7d6290fa3cfd	RHEA:18438	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18438		"[{""reference_id"": ""RHEA:18438"", ""source_assertion"": ""Rhea RHEA:18438 places CHEBI:456216 on its products side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18438']/rh:products; http://rdf.rhea-db.org/18437_R/rh:contains1; http://rdf.rhea-db.org/Participant_18437_compound_2710/rh:compound; http://rdf.rhea-db.org/Compound_2710/rh:accession""}]"	"[{""id"": ""RHEA:18438"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 18438: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/18438""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-023_5f381c44fa56	RHEA:18438	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18438		"[{""reference_id"": ""RHEA:18438"", ""source_assertion"": ""Rhea RHEA:18438 places CHEBI:15378 on its products side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18438']/rh:products; http://rdf.rhea-db.org/18437_R/rh:contains1; http://rdf.rhea-db.org/Participant_18437_compound_3249/rh:compound; http://rdf.rhea-db.org/Compound_3249/rh:accession""}]"	"[{""id"": ""RHEA:18438"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 18438: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/18438""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-024_f6925a505c33	UniProtKB:P62615	pathwaymech:catalyzes	RHEA:18438	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P62615		"[{""reference_id"": ""UniProtKB:P62615"", ""source_assertion"": ""UniProt UniProtKB:P62615 assigns catalytic activity to RHEA:18437, the reaction family of RHEA:18438; organism NCBITaxon:83333. Annotation evidence: ECO:0000269."", ""source_locator"": ""results[primaryAccession='P62615'].comments[1].reaction""}]"	"[{""id"": ""UniProtKB:P62615"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB P62615: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/P62615.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-025_06a740c8430b	CHEBI:57919	pathwaymech:consumes	RHEA:23865	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23865		"[{""reference_id"": ""RHEA:23865"", ""source_assertion"": ""Rhea RHEA:23865 places CHEBI:57919 on its substrates side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23865']/rh:substrates; http://rdf.rhea-db.org/23864_L/rh:contains1; http://rdf.rhea-db.org/Participant_23864_compound_1085/rh:compound; http://rdf.rhea-db.org/Compound_1085/rh:accession""}]"	"[{""id"": ""RHEA:23865"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 23865: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/23865""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-026_fa807034996d	RHEA:23865	pathwaymech:produces	CHEBI:58483	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23865		"[{""reference_id"": ""RHEA:23865"", ""source_assertion"": ""Rhea RHEA:23865 places CHEBI:58483 on its products side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23865']/rh:products; http://rdf.rhea-db.org/23864_R/rh:contains1; http://rdf.rhea-db.org/Participant_23864_compound_2953/rh:compound; http://rdf.rhea-db.org/Compound_2953/rh:accession""}]"	"[{""id"": ""RHEA:23865"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 23865: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/23865""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-027_1712e0a8ff8d	RHEA:23865	pathwaymech:produces	CHEBI:60377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23865		"[{""reference_id"": ""RHEA:23865"", ""source_assertion"": ""Rhea RHEA:23865 places CHEBI:60377 on its products side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23865']/rh:products; http://rdf.rhea-db.org/23864_R/rh:contains1; http://rdf.rhea-db.org/Participant_23864_compound_3543/rh:compound; http://rdf.rhea-db.org/Compound_3543/rh:accession""}]"	"[{""id"": ""RHEA:23865"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 23865: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/23865""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-028_5e38d1386556	UniProtKB:P62617	pathwaymech:catalyzes	RHEA:23865	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P62617		"[{""reference_id"": ""UniProtKB:P62617"", ""source_assertion"": ""UniProt UniProtKB:P62617 assigns catalytic activity to RHEA:23864, the reaction family of RHEA:23865; organism NCBITaxon:83333. Annotation evidence: ECO:0000255, ECO:0000269."", ""source_locator"": ""results[primaryAccession='P62617'].comments[1].reaction""}]"	"[{""id"": ""UniProtKB:P62617"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB P62617: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/P62617.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-029_f04fe63e5ca8	CHEBI:58483	pathwaymech:consumes	RHEA:43606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43606	Chemical-side projection only: source generic electron-carrier states are not represented. This edge does not establish a balanced complete reaction or the physiological donor identity.	"[{""reference_id"": ""RHEA:43606"", ""source_assertion"": ""Rhea RHEA:43606 places CHEBI:58483 on its substrates side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/43606']/rh:substrates; http://rdf.rhea-db.org/43604_R/rh:contains1; http://rdf.rhea-db.org/Participant_43604_compound_2953/rh:compound; http://rdf.rhea-db.org/Compound_2953/rh:accession""}]"	"[{""id"": ""RHEA:43606"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 43606: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/43606""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-030_d16807f034d1	RHEA:43606	pathwaymech:produces	CHEBI:128753	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43606	Chemical-side projection only: source generic electron-carrier states are not represented. This edge does not establish a balanced complete reaction or the physiological donor identity.	"[{""reference_id"": ""RHEA:43606"", ""source_assertion"": ""Rhea RHEA:43606 places CHEBI:128753 on its products side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/43606']/rh:products; http://rdf.rhea-db.org/43604_L/rh:contains1; http://rdf.rhea-db.org/Participant_43604_compound_2971/rh:compound; http://rdf.rhea-db.org/Compound_2971/rh:accession""}]"	"[{""id"": ""RHEA:43606"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 43606: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/43606""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-031_9e83db850fd3	RHEA:43606	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43606	Chemical-side projection only: source generic electron-carrier states are not represented. This edge does not establish a balanced complete reaction or the physiological donor identity.	"[{""reference_id"": ""RHEA:43606"", ""source_assertion"": ""Rhea RHEA:43606 places CHEBI:15377 on its products side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/43606']/rh:products; http://rdf.rhea-db.org/43604_L/rh:contains1; http://rdf.rhea-db.org/Participant_43604_compound_1283/rh:compound; http://rdf.rhea-db.org/Compound_1283/rh:accession""}]"	"[{""id"": ""RHEA:43606"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 43606: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/43606""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-032_c850ee5d8130	RHEA:43606	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43606	Chemical-side projection only: source generic electron-carrier states are not represented. This edge does not establish a balanced complete reaction or the physiological donor identity.	"[{""reference_id"": ""RHEA:43606"", ""source_assertion"": ""Rhea RHEA:43606 places CHEBI:15378 on its products side; coefficient 2."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/43606']/rh:products; http://rdf.rhea-db.org/43604_L/rh:contains2; http://rdf.rhea-db.org/Participant_43604_compound_3249/rh:compound; http://rdf.rhea-db.org/Compound_3249/rh:accession""}]"	"[{""id"": ""RHEA:43606"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 43606: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/43606""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-033_836778c77e91	UniProtKB:P62620	pathwaymech:catalyzes	RHEA:43606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P62620		"[{""reference_id"": ""UniProtKB:P62620"", ""source_assertion"": ""UniProt UniProtKB:P62620 assigns catalytic activity to RHEA:43604, the reaction family of RHEA:43606; organism NCBITaxon:83333. Annotation evidence: ECO:0000255, ECO:0000269."", ""source_locator"": ""results[primaryAccession='P62620'].comments[1].reaction""}]"	"[{""id"": ""UniProtKB:P62620"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB P62620: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/P62620.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-034_7a55c7be1064	CHEBI:128753	pathwaymech:consumes	RHEA:24490	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24490	Chemical-side projection only: source generic electron-carrier states are not represented. This edge does not establish a balanced complete reaction or the physiological donor identity.	"[{""reference_id"": ""RHEA:24490"", ""source_assertion"": ""Rhea RHEA:24490 places CHEBI:128753 on its substrates side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24490']/rh:substrates; http://rdf.rhea-db.org/24488_R/rh:contains1; http://rdf.rhea-db.org/Participant_24488_compound_2971/rh:compound; http://rdf.rhea-db.org/Compound_2971/rh:accession""}]"	"[{""id"": ""RHEA:24490"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 24490: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/24490""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-035_bbbee14f0ad5	CHEBI:15378	pathwaymech:consumes	RHEA:24490	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24490	Chemical-side projection only: source generic electron-carrier states are not represented. This edge does not establish a balanced complete reaction or the physiological donor identity.	"[{""reference_id"": ""RHEA:24490"", ""source_assertion"": ""Rhea RHEA:24490 places CHEBI:15378 on its substrates side; coefficient 2."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24490']/rh:substrates; http://rdf.rhea-db.org/24488_R/rh:contains2; http://rdf.rhea-db.org/Participant_24488_compound_3249/rh:compound; http://rdf.rhea-db.org/Compound_3249/rh:accession""}]"	"[{""id"": ""RHEA:24490"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 24490: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/24490""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-036_e10961b01c9b	RHEA:24490	pathwaymech:produces	CHEBI:128769	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24490	Chemical-side projection only: source generic electron-carrier states are not represented. This edge does not establish a balanced complete reaction or the physiological donor identity.	"[{""reference_id"": ""RHEA:24490"", ""source_assertion"": ""Rhea RHEA:24490 places CHEBI:128769 on its products side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24490']/rh:products; http://rdf.rhea-db.org/24488_L/rh:contains1; http://rdf.rhea-db.org/Participant_24488_compound_4425/rh:compound; http://rdf.rhea-db.org/Compound_4425/rh:accession""}]"	"[{""id"": ""RHEA:24490"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 24490: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/24490""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-037_dbcef40ff668	RHEA:24490	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24490	Chemical-side projection only: source generic electron-carrier states are not represented. This edge does not establish a balanced complete reaction or the physiological donor identity.	"[{""reference_id"": ""RHEA:24490"", ""source_assertion"": ""Rhea RHEA:24490 places CHEBI:15377 on its products side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24490']/rh:products; http://rdf.rhea-db.org/24488_L/rh:contains1; http://rdf.rhea-db.org/Participant_24488_compound_1283/rh:compound; http://rdf.rhea-db.org/Compound_1283/rh:accession""}]"	"[{""id"": ""RHEA:24490"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 24490: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/24490""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-038_a806cd972448	UniProtKB:P62623	pathwaymech:catalyzes	RHEA:24490	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P62623	The supported IspH chemical conversion is retained. Its UniProt/Rhea generic ferredoxin equation does not establish the E. coli physiological donor; flavodoxin-dependent activation was observed in PMID:12571359.	"[{""reference_id"": ""UniProtKB:P62623"", ""source_assertion"": ""UniProt UniProtKB:P62623 assigns catalytic activity to RHEA:24488, the reaction family of RHEA:24490; organism NCBITaxon:83333. Annotation evidence: ECO:0000269."", ""source_locator"": ""results[primaryAccession='P62623'].comments[1].reaction""}]"	"[{""id"": ""UniProtKB:P62623"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB P62623: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/P62623.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-039_4e2eec0a3826	CHEBI:128753	pathwaymech:consumes	RHEA:24827	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24827	Chemical-side projection only: source generic electron-carrier states are not represented. This edge does not establish a balanced complete reaction or the physiological donor identity.	"[{""reference_id"": ""RHEA:24827"", ""source_assertion"": ""Rhea RHEA:24827 places CHEBI:128753 on its substrates side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24827']/rh:substrates; http://rdf.rhea-db.org/24825_R/rh:contains1; http://rdf.rhea-db.org/Participant_24825_compound_2971/rh:compound; http://rdf.rhea-db.org/Compound_2971/rh:accession""}]"	"[{""id"": ""RHEA:24827"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 24827: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/24827""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-040_7e12f5a8ad3d	CHEBI:15378	pathwaymech:consumes	RHEA:24827	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24827	Chemical-side projection only: source generic electron-carrier states are not represented. This edge does not establish a balanced complete reaction or the physiological donor identity.	"[{""reference_id"": ""RHEA:24827"", ""source_assertion"": ""Rhea RHEA:24827 places CHEBI:15378 on its substrates side; coefficient 2."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24827']/rh:substrates; http://rdf.rhea-db.org/24825_R/rh:contains2; http://rdf.rhea-db.org/Participant_24825_compound_3249/rh:compound; http://rdf.rhea-db.org/Compound_3249/rh:accession""}]"	"[{""id"": ""RHEA:24827"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 24827: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/24827""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-041_34a6cf02c8ba	RHEA:24827	pathwaymech:produces	CHEBI:57623	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24827	Chemical-side projection only: source generic electron-carrier states are not represented. This edge does not establish a balanced complete reaction or the physiological donor identity.	"[{""reference_id"": ""RHEA:24827"", ""source_assertion"": ""Rhea RHEA:24827 places CHEBI:57623 on its products side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24827']/rh:products; http://rdf.rhea-db.org/24825_L/rh:contains1; http://rdf.rhea-db.org/Participant_24825_compound_1833/rh:compound; http://rdf.rhea-db.org/Compound_1833/rh:accession""}]"	"[{""id"": ""RHEA:24827"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 24827: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/24827""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-042_c9f6c74d6976	RHEA:24827	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24827	Chemical-side projection only: source generic electron-carrier states are not represented. This edge does not establish a balanced complete reaction or the physiological donor identity.	"[{""reference_id"": ""RHEA:24827"", ""source_assertion"": ""Rhea RHEA:24827 places CHEBI:15377 on its products side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24827']/rh:products; http://rdf.rhea-db.org/24825_L/rh:contains1; http://rdf.rhea-db.org/Participant_24825_compound_1283/rh:compound; http://rdf.rhea-db.org/Compound_1283/rh:accession""}]"	"[{""id"": ""RHEA:24827"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 24827: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/24827""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-043_a9d04f83e259	UniProtKB:P62623	pathwaymech:catalyzes	RHEA:24827	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P62623	The supported IspH chemical conversion is retained. Its UniProt/Rhea generic ferredoxin equation does not establish the E. coli physiological donor; flavodoxin-dependent activation was observed in PMID:12571359.	"[{""reference_id"": ""UniProtKB:P62623"", ""source_assertion"": ""UniProt UniProtKB:P62623 assigns catalytic activity to RHEA:24825, the reaction family of RHEA:24827; organism NCBITaxon:83333. Annotation evidence: ECO:0000269."", ""source_locator"": ""results[primaryAccession='P62623'].comments[2].reaction""}]"	"[{""id"": ""UniProtKB:P62623"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB P62623: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/P62623.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-044_699c685a33cf	CHEBI:128769	pathwaymech:consumes	RHEA:23285	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23285		"[{""reference_id"": ""RHEA:23285"", ""source_assertion"": ""Rhea RHEA:23285 places CHEBI:128769 on its substrates side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23285']/rh:substrates; http://rdf.rhea-db.org/23284_L/rh:contains1; http://rdf.rhea-db.org/Participant_23284_compound_4425/rh:compound; http://rdf.rhea-db.org/Compound_4425/rh:accession""}]"	"[{""id"": ""RHEA:23285"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 23285: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/23285""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-045_f0d9d6ee2b86	RHEA:23285	pathwaymech:produces	CHEBI:57623	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23285		"[{""reference_id"": ""RHEA:23285"", ""source_assertion"": ""Rhea RHEA:23285 places CHEBI:57623 on its products side; coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23285']/rh:products; http://rdf.rhea-db.org/23284_R/rh:contains1; http://rdf.rhea-db.org/Participant_23284_compound_1833/rh:compound; http://rdf.rhea-db.org/Compound_1833/rh:accession""}]"	"[{""id"": ""RHEA:23285"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); exact input is the complete official rhea.rdf.gz archive"", ""title"": ""Rhea 23285: source-oriented reaction definition"", ""url"": ""https://www.rhea-db.org/rhea/23285""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-046_8e224c65d58d	UniProtKB:Q46822	pathwaymech:catalyzes	RHEA:23285	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q46822	Additional IPP/DMAPP interconversion. IspH already produces both products; this is not an obligatory DMAPP-forming step. Left-to-right is the source-selected orientation, not a claim of irreversibility.	"[{""reference_id"": ""UniProtKB:Q46822"", ""source_assertion"": ""UniProt UniProtKB:Q46822 assigns catalytic activity to RHEA:23284, the reaction family of RHEA:23285; organism NCBITaxon:83333. Annotation evidence: ECO:0000269."", ""source_locator"": ""results[primaryAccession='Q46822'].comments[1].reaction""}]"	"[{""id"": ""UniProtKB:Q46822"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB Q46822: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q46822.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-047_2e5e775a8fb9	RHEA:43606	pathwaymech:precedes	RHEA:24490	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:NONMEVIPP-PWY	Native pathway ordering projected to the reviewed reaction mappings.	"[{""reference_id"": ""MetaCyc:NONMEVIPP-PWY"", ""source_assertion"": ""MetaCyc NONMEVIPP-PWY lists RXN-15878 as a predecessor reaction of ISPH2-RXN. The reviewed reaction mappings are RHEA:43606 and RHEA:24490, respectively."", ""source_locator"": ""Pathway[@frameid='NONMEVIPP-PWY']/reaction-ordering[Reaction/@frameid='ISPH2-RXN']/predecessor-reactions/Reaction[@frameid='RXN-15878']""}]"	"[{""id"": ""MetaCyc:NONMEVIPP-PWY"", ""source_sha256"": ""979f165dc2dbc2bb49906d4335cad3db7d207b5b4a878ff05f9f57f4ad8c1744"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-10"", ""title"": ""MetaCyc methylerythritol phosphate pathway I, native pathway definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:NONMEVIPP-PWY""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-048_fd3684277d1f	RHEA:43606	pathwaymech:precedes	RHEA:24827	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:NONMEVIPP-PWY	Native pathway ordering projected to the reviewed reaction mappings.	"[{""reference_id"": ""MetaCyc:NONMEVIPP-PWY"", ""source_assertion"": ""MetaCyc NONMEVIPP-PWY lists RXN-15878 as a predecessor reaction of RXN0-884. The reviewed reaction mappings are RHEA:43606 and RHEA:24827, respectively."", ""source_locator"": ""Pathway[@frameid='NONMEVIPP-PWY']/reaction-ordering[Reaction/@frameid='RXN0-884']/predecessor-reactions/Reaction[@frameid='RXN-15878']""}]"	"[{""id"": ""MetaCyc:NONMEVIPP-PWY"", ""source_sha256"": ""979f165dc2dbc2bb49906d4335cad3db7d207b5b4a878ff05f9f57f4ad8c1744"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-10"", ""title"": ""MetaCyc methylerythritol phosphate pathway I, native pathway definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:NONMEVIPP-PWY""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-049_26bdf93f63d7	RHEA:23865	pathwaymech:precedes	RHEA:43606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:NONMEVIPP-PWY	Native pathway ordering projected to the reviewed reaction mappings.	"[{""reference_id"": ""MetaCyc:NONMEVIPP-PWY"", ""source_assertion"": ""MetaCyc NONMEVIPP-PWY lists RXN0-302 as a predecessor reaction of RXN-15878. The reviewed reaction mappings are RHEA:23865 and RHEA:43606, respectively."", ""source_locator"": ""Pathway[@frameid='NONMEVIPP-PWY']/reaction-ordering[Reaction/@frameid='RXN-15878']/predecessor-reactions/Reaction[@frameid='RXN0-302']""}]"	"[{""id"": ""MetaCyc:NONMEVIPP-PWY"", ""source_sha256"": ""979f165dc2dbc2bb49906d4335cad3db7d207b5b4a878ff05f9f57f4ad8c1744"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-10"", ""title"": ""MetaCyc methylerythritol phosphate pathway I, native pathway definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:NONMEVIPP-PWY""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-050_cb3fb8631d52	RHEA:13719	pathwaymech:precedes	RHEA:13430	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:NONMEVIPP-PWY	Native pathway ordering projected to the reviewed reaction mappings.	"[{""reference_id"": ""MetaCyc:NONMEVIPP-PWY"", ""source_assertion"": ""MetaCyc NONMEVIPP-PWY lists DXPREDISOM-RXN as a predecessor reaction of 2.7.7.60-RXN. The reviewed reaction mappings are RHEA:13719 and RHEA:13430, respectively."", ""source_locator"": ""Pathway[@frameid='NONMEVIPP-PWY']/reaction-ordering[Reaction/@frameid='2.7.7.60-RXN']/predecessor-reactions/Reaction[@frameid='DXPREDISOM-RXN']""}]"	"[{""id"": ""MetaCyc:NONMEVIPP-PWY"", ""source_sha256"": ""979f165dc2dbc2bb49906d4335cad3db7d207b5b4a878ff05f9f57f4ad8c1744"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-10"", ""title"": ""MetaCyc methylerythritol phosphate pathway I, native pathway definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:NONMEVIPP-PWY""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-051_0336e4f6c5a3	RHEA:12606	pathwaymech:precedes	RHEA:13719	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:NONMEVIPP-PWY	Native pathway ordering projected to the reviewed reaction mappings.	"[{""reference_id"": ""MetaCyc:NONMEVIPP-PWY"", ""source_assertion"": ""MetaCyc NONMEVIPP-PWY lists DXS-RXN as a predecessor reaction of DXPREDISOM-RXN. The reviewed reaction mappings are RHEA:12606 and RHEA:13719, respectively."", ""source_locator"": ""Pathway[@frameid='NONMEVIPP-PWY']/reaction-ordering[Reaction/@frameid='DXPREDISOM-RXN']/predecessor-reactions/Reaction[@frameid='DXS-RXN']""}]"	"[{""id"": ""MetaCyc:NONMEVIPP-PWY"", ""source_sha256"": ""979f165dc2dbc2bb49906d4335cad3db7d207b5b4a878ff05f9f57f4ad8c1744"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-10"", ""title"": ""MetaCyc methylerythritol phosphate pathway I, native pathway definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:NONMEVIPP-PWY""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-052_69a58e453bd4	RHEA:13430	pathwaymech:precedes	RHEA:18438	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:NONMEVIPP-PWY	Native pathway ordering projected to the reviewed reaction mappings.	"[{""reference_id"": ""MetaCyc:NONMEVIPP-PWY"", ""source_assertion"": ""MetaCyc NONMEVIPP-PWY lists 2.7.7.60-RXN as a predecessor reaction of 2.7.1.148-RXN. The reviewed reaction mappings are RHEA:13430 and RHEA:18438, respectively."", ""source_locator"": ""Pathway[@frameid='NONMEVIPP-PWY']/reaction-ordering[Reaction/@frameid='2.7.1.148-RXN']/predecessor-reactions/Reaction[@frameid='2.7.7.60-RXN']""}]"	"[{""id"": ""MetaCyc:NONMEVIPP-PWY"", ""source_sha256"": ""979f165dc2dbc2bb49906d4335cad3db7d207b5b4a878ff05f9f57f4ad8c1744"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-10"", ""title"": ""MetaCyc methylerythritol phosphate pathway I, native pathway definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:NONMEVIPP-PWY""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-053_6b4f5dd27527	RHEA:18438	pathwaymech:precedes	RHEA:23865	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:NONMEVIPP-PWY	Native pathway ordering projected to the reviewed reaction mappings.	"[{""reference_id"": ""MetaCyc:NONMEVIPP-PWY"", ""source_assertion"": ""MetaCyc NONMEVIPP-PWY lists 2.7.1.148-RXN as a predecessor reaction of RXN0-302. The reviewed reaction mappings are RHEA:18438 and RHEA:23865, respectively."", ""source_locator"": ""Pathway[@frameid='NONMEVIPP-PWY']/reaction-ordering[Reaction/@frameid='RXN0-302']/predecessor-reactions/Reaction[@frameid='2.7.1.148-RXN']""}]"	"[{""id"": ""MetaCyc:NONMEVIPP-PWY"", ""source_sha256"": ""979f165dc2dbc2bb49906d4335cad3db7d207b5b4a878ff05f9f57f4ad8c1744"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-10"", ""title"": ""MetaCyc methylerythritol phosphate pathway I, native pathway definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:NONMEVIPP-PWY""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-054_639d528cba3b	RHEA:24490	pathwaymech:precedes	RHEA:23285	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:NONMEVIPP-PWY	Native ordering places optional Idi after the IPP-forming IspH branch; the separate IspH DMAPP-producing branch is retained and does not require Idi.	"[{""reference_id"": ""MetaCyc:NONMEVIPP-PWY"", ""source_assertion"": ""MetaCyc NONMEVIPP-PWY lists ISPH2-RXN as a predecessor reaction of IPPISOM-RXN. The reviewed reaction mappings are RHEA:24490 and RHEA:23285, respectively."", ""source_locator"": ""Pathway[@frameid='NONMEVIPP-PWY']/reaction-ordering[Reaction/@frameid='IPPISOM-RXN']/predecessor-reactions/Reaction[@frameid='ISPH2-RXN']""}]"	"[{""id"": ""MetaCyc:NONMEVIPP-PWY"", ""source_sha256"": ""979f165dc2dbc2bb49906d4335cad3db7d207b5b4a878ff05f9f57f4ad8c1744"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-10"", ""title"": ""MetaCyc methylerythritol phosphate pathway I, native pathway definition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:NONMEVIPP-PWY""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-055_053c3715b0f2	UniProtKB:P77488	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77488	Binds 1 Mg(2+) ion per subunit.	"[{""reference_id"": ""UniProtKB:P77488"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P77488. Annotation evidence: ECO:0000269."", ""source_locator"": ""results[primaryAccession='P77488'].comments[2].cofactors[0] and note""}]"	"[{""id"": ""UniProtKB:P77488"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB P77488: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77488.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-056_0834ef577dd9	UniProtKB:P77488	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77488	Binds 1 thiamine pyrophosphate per subunit.	"[{""reference_id"": ""UniProtKB:P77488"", ""source_assertion"": ""UniProt lists CHEBI:58937 as a cofactor of UniProtKB:P77488. Annotation evidence: ECO:0000269."", ""source_locator"": ""results[primaryAccession='P77488'].comments[3].cofactors[0] and note""}]"	"[{""id"": ""UniProtKB:P77488"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB P77488: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77488.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-057_38fa30f28af9	UniProtKB:P45568	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P45568	Divalent cation. Prefers Mg(2+), Mn(2+) or Co(2+). These listed metal possibilities do not assert that all three metals are simultaneously required.	"[{""reference_id"": ""UniProtKB:P45568"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P45568. Annotation evidence: ECO:0000269."", ""source_locator"": ""results[primaryAccession='P45568'].comments[2].cofactors[0] and note""}]"	"[{""id"": ""UniProtKB:P45568"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB P45568: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/P45568.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-058_218c4dabfa59	UniProtKB:P45568	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P45568	Divalent cation. Prefers Mg(2+), Mn(2+) or Co(2+). These listed metal possibilities do not assert that all three metals are simultaneously required.	"[{""reference_id"": ""UniProtKB:P45568"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P45568. Annotation evidence: ECO:0000269."", ""source_locator"": ""results[primaryAccession='P45568'].comments[2].cofactors[1] and note""}]"	"[{""id"": ""UniProtKB:P45568"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB P45568: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/P45568.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-059_551b5bb7a7b6	UniProtKB:P45568	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P45568	Divalent cation. Prefers Mg(2+), Mn(2+) or Co(2+). These listed metal possibilities do not assert that all three metals are simultaneously required.	"[{""reference_id"": ""UniProtKB:P45568"", ""source_assertion"": ""UniProt lists CHEBI:48828 as a cofactor of UniProtKB:P45568. Annotation evidence: ECO:0000269."", ""source_locator"": ""results[primaryAccession='P45568'].comments[2].cofactors[2] and note""}]"	"[{""id"": ""UniProtKB:P45568"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB P45568: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/P45568.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-060_f483b1fa2a4a	UniProtKB:Q46893	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q46893	These listed metal possibilities do not assert that all three metals are simultaneously required. The source field supplies no evidence code; no direct experimental claim is inferred.	"[{""reference_id"": ""UniProtKB:Q46893"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:Q46893. Annotation evidence: no evidence code supplied on this source field."", ""source_locator"": ""results[primaryAccession='Q46893'].comments[2].cofactors[0] and note""}]"	"[{""id"": ""UniProtKB:Q46893"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB Q46893: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q46893.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-061_97763a35f4d1	UniProtKB:Q46893	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q46893	These listed metal possibilities do not assert that all three metals are simultaneously required. The source field supplies no evidence code; no direct experimental claim is inferred.	"[{""reference_id"": ""UniProtKB:Q46893"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:Q46893. Annotation evidence: no evidence code supplied on this source field."", ""source_locator"": ""results[primaryAccession='Q46893'].comments[2].cofactors[1] and note""}]"	"[{""id"": ""UniProtKB:Q46893"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB Q46893: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q46893.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-062_ddb4e11c852d	UniProtKB:Q46893	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q46893	These listed metal possibilities do not assert that all three metals are simultaneously required. The source field supplies no evidence code; no direct experimental claim is inferred.	"[{""reference_id"": ""UniProtKB:Q46893"", ""source_assertion"": ""UniProt lists CHEBI:48828 as a cofactor of UniProtKB:Q46893. Annotation evidence: no evidence code supplied on this source field."", ""source_locator"": ""results[primaryAccession='Q46893'].comments[2].cofactors[2] and note""}]"	"[{""id"": ""UniProtKB:Q46893"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB Q46893: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q46893.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-063_46c5ec46d8f8	UniProtKB:P62617	pathwaymech:has_cofactor	CHEBI:60240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P62617	Binds 1 divalent metal cation per subunit.	"[{""reference_id"": ""UniProtKB:P62617"", ""source_assertion"": ""UniProt lists CHEBI:60240 as a cofactor of UniProtKB:P62617. Annotation evidence: ECO:0000255, ECO:0000269."", ""source_locator"": ""results[primaryAccession='P62617'].comments[3].cofactors[0] and note""}]"	"[{""id"": ""UniProtKB:P62617"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB P62617: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/P62617.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-064_1b322b991262	UniProtKB:P62620	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P62620	Binds 1 [4Fe-4S] cluster.	"[{""reference_id"": ""UniProtKB:P62620"", ""source_assertion"": ""UniProt lists CHEBI:49883 as a cofactor of UniProtKB:P62620. Annotation evidence: ECO:0000255, ECO:0000269."", ""source_locator"": ""results[primaryAccession='P62620'].comments[2].cofactors[0] and note""}]"	"[{""id"": ""UniProtKB:P62620"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB P62620: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/P62620.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-065_30284cd9d354	UniProtKB:P62623	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P62623	Was shown to bind 1 [3Fe-4S] cluster per subunit (PubMed:15469281, PubMed:19569147, PubMed:20080550). However, it initially contains a [4Fe-4S] cluster which easily degrades into a [3Fe-4S] form in the presence of oxygen (PubMed:12706830, PubMed:20080550, PubMed:22137895, PubMed:22687151).	"[{""reference_id"": ""UniProtKB:P62623"", ""source_assertion"": ""UniProt lists CHEBI:49883 as a cofactor of UniProtKB:P62623. Annotation evidence: ECO:0000269."", ""source_locator"": ""results[primaryAccession='P62623'].comments[3].cofactors[0] and note""}]"	"[{""id"": ""UniProtKB:P62623"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB P62623: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/P62623.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-066_966fd9077f40	UniProtKB:Q46822	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q46822	Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.	"[{""reference_id"": ""UniProtKB:Q46822"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:Q46822. Annotation evidence: ECO:0000269."", ""source_locator"": ""results[primaryAccession='Q46822'].comments[2].cofactors[0] and note""}]"	"[{""id"": ""UniProtKB:Q46822"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB Q46822: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q46822.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-067_d6943d3cb904	UniProtKB:Q46822	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q46822	Binds 1 Mn(2+) ion per subunit.	"[{""reference_id"": ""UniProtKB:Q46822"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:Q46822. Annotation evidence: ECO:0000269."", ""source_locator"": ""results[primaryAccession='Q46822'].comments[3].cofactors[0] and note""}]"	"[{""id"": ""UniProtKB:Q46822"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB Q46822: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q46822.json""}]"	""
pathwaymech:MetaCyc_NONMEVIPP-PWY_edge-068_fdac5ee575b2	UniProtKB:Q46822	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q46822	Contextual localization of Idi only; does not establish localization or exclusivity for other pathway proteins.	"[{""reference_id"": ""UniProtKB:Q46822"", ""source_assertion"": ""UniProt lists cytoplasm (SL-0086) and explicitly cross-references GO:0005737 for Q46822. The GO location cross-reference has evidence IEA:UniProtKB-SubCell."", ""source_locator"": ""results[primaryAccession='Q46822'].uniProtKBCrossReferences[database='GO'][id='GO:0005737'].properties; comments[7].subcellularLocations""}]"	"[{""id"": ""UniProtKB:Q46822"", ""source_sha256"": ""f4b9963571d05122d6a5327dac5e0dcb3893ff688190ba9a394c99d7902e27fb"", ""source_version"": ""retrieved 2026-10-10; digest scope is the complete eight-entry batch JSON"", ""title"": ""UniProtKB Q46822: Escherichia coli K-12 enzyme annotation"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q46822.json""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-001_89340c803d0d	gomodel:YeastPathways_PWY-901/6a46ef0600000777	BFO:0000050	GO:0051596	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-901/6a46ef0600000777 BFO:0000050 gomodel:YeastPathways_PWY-901/YeastPathways_PWY-901."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/0; endpoint types: /individuals/26/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-002_e8e6b4ee8356	gomodel:YeastPathways_PWY-901/6a46ef0600000777	RO:0002234	CHEBI:57925	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-901/6a46ef0600000777 RO:0002234 gomodel:YeastPathways_PWY-901/6a46ef0600000781."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/1; endpoint types: /individuals/26/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-003_5c6f82b73e05	gomodel:YeastPathways_PWY-901/6a46ef0600000777	RO:0002234	CHEBI:16004	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-901/6a46ef0600000777 RO:0002234 gomodel:YeastPathways_PWY-901/6a46ef0600000780."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/2; endpoint types: /individuals/26/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-004_bb3cd40904c7	gomodel:GLYOXII-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:GLYOXII-RXN RO:0002234 gomodel:CHEBI_15378_GLYOXII-RXN."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/3; endpoint types: /individuals/8/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-005_16765fe3c473	gomodel:GLYOXI-RXN	RO:0002233	CHEBI:57925	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:GLYOXI-RXN RO:0002233 gomodel:CHEBI_57925_GLYOXI-RXN."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/4; endpoint types: /individuals/7/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-006_76a92a4ca559	gomodel:GLYOXI-RXN	RO:0002233	CHEBI:17158	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:GLYOXI-RXN RO:0002233 gomodel:CHEBI_17158_GLYOXI-RXN."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/5; endpoint types: /individuals/7/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-007_8c64f4a95806	gomodel:GLYOXII-RXN	RO:0002233	CHEBI:57474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:GLYOXII-RXN RO:0002233 gomodel:CHEBI_57474_GLYOXI-RXN."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/6; endpoint types: /individuals/8/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-008_439f887dbe92	SGD:S000002680	pathwaymech:enables	gomodel:GLYOXII-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:GLYOXII-RXN RO:0002333 gomodel:YDR272W-MONOMER_GLYOXII-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/7; endpoint types: /individuals/8/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-010_af76ee66a99c	gomodel:YeastPathways_PWY-901/6a46ef0600000777	RO:0002233	CHEBI:57474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-901/6a46ef0600000777 RO:0002233 gomodel:CHEBI_57474_GLYOXI-RXN."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/9; endpoint types: /individuals/26/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-011_5e809951f418	gomodel:YeastPathways_PWY-901/6a46ef0600000777	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-901/6a46ef0600000777 RO:0002233 gomodel:YeastPathways_PWY-901/6a46ef0600000778."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/10; endpoint types: /individuals/26/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-012_6e36eb23fa57	SGD:S000004463	pathwaymech:enables	gomodel:GLYOXI-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:GLYOXI-RXN RO:0002333 gomodel:YML004C-MONOMER_GLYOXI-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/11; endpoint types: /individuals/7/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-013_efaae0c9f439	gomodel:GLYOXII-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:GLYOXII-RXN RO:0002233 gomodel:CHEBI_15377_GLYOXII-RXN."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/12; endpoint types: /individuals/8/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-014_4373762cc918	gomodel:GLYOXII-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:GLYOXII-RXN BFO:0000066 gomodel:reaction_GLYOXII-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/13; endpoint types: /individuals/8/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-015_40e2efa2ddc2	gomodel:GLYOXI-RXN	RO:0002234	CHEBI:57474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:GLYOXI-RXN RO:0002234 gomodel:CHEBI_57474_GLYOXI-RXN."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/14; endpoint types: /individuals/7/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-016_ffc60e429996	gomodel:YeastPathways_PWY-901/6a46ef0600000777	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-901/6a46ef0600000777 RO:0002234 gomodel:YeastPathways_PWY-901/6a46ef0600000779."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/15; endpoint types: /individuals/26/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-017_8677646e1e76	gomodel:GLYOXI-RXN	BFO:0000050	GO:0051596	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:GLYOXI-RXN BFO:0000050 gomodel:YeastPathways_PWY-901/YeastPathways_PWY-901."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/16; endpoint types: /individuals/7/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-018_ce3211d65863	gomodel:GLYOXI-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:GLYOXI-RXN BFO:0000066 gomodel:reaction_GLYOXI-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/17; endpoint types: /individuals/7/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-019_d2317a1cf4bc	gomodel:GLYOXII-RXN	RO:0002234	CHEBI:16004	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:GLYOXII-RXN RO:0002234 gomodel:CHEBI_16004_GLYOXII-RXN."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/18; endpoint types: /individuals/8/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-020_cbbfce13b959	gomodel:GLYOXII-RXN	BFO:0000050	GO:0051596	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:GLYOXII-RXN BFO:0000050 gomodel:YeastPathways_PWY-901/YeastPathways_PWY-901."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/19; endpoint types: /individuals/8/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-021_a44cfd7c9944	gomodel:GLYOXII-RXN	RO:0002234	CHEBI:57925	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:GLYOXII-RXN RO:0002234 gomodel:CHEBI_57925_GLYOXII-RXN."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/20; endpoint types: /individuals/8/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_edge-022_bd923aa33d1f	SGD:S000005566	pathwaymech:enables	gomodel:YeastPathways_PWY-901/6a46ef0600000777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-901		"[{""reference_id"": ""gomodel:YeastPathways_PWY-901"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-901/6a46ef0600000777 RO:0002333 gomodel:YeastPathways_PWY-901/6a46ef0600000783."", ""source_locator"": ""./YeastPathways_PWY-901.json#/facts/21; endpoint types: /individuals/26/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-901"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-901.json"", ""title"": ""SGD GO-CAM methylglyoxal catabolism pathway PWY-901"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_location-3bb6137d35ec_5e6abfcfec34	SGD:S000002680	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q05584	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:9261170)	"[{""reference_id"": ""UniProtKB:Q05584"", ""source_assertion"": ""UniProtKB:Q05584 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2679/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q05584"", ""source_assertion"": ""UniProtKB:Q05584 has the exact SGD cross-reference SGD:S000002680."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2679/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q05584"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q05584 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_location-86edfc2d0c6a_76f96e6770a5	SGD:S000005566	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12320	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:9261170)	"[{""reference_id"": ""UniProtKB:Q12320"", ""source_assertion"": ""UniProtKB:Q12320 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3059/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q12320"", ""source_assertion"": ""UniProtKB:Q12320 has the exact SGD cross-reference SGD:S000005566."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3059/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q12320"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12320 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_cofactor-3263ffaee847_b00a570e8baa	SGD:S000002680	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q05584	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The caution concerns identities of older glyoxalase preparations, not the current GLO2 zinc annotation; retain the explicit inference from a human homolog. UniProt evidence: ECO:0000250 (UniProtKB:Q16775) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:Q16775)	"[{""reference_id"": ""UniProtKB:Q05584"", ""source_assertion"": ""UniProtKB:Q05584 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2679/comments/0/cofactors/0; /results/2679/comments/0/note""}, {""reference_id"": ""UniProtKB:Q05584"", ""source_assertion"": ""UniProtKB:Q05584 has the exact SGD cross-reference SGD:S000002680."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2679/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q05584"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q05584 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_cofactor-701d2ba34569_62bf86d497f2	SGD:S000004463	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P50107	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q04760) Binds 1 zinc ion per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:Q04760)	"[{""reference_id"": ""UniProtKB:P50107"", ""source_assertion"": ""UniProtKB:P50107 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2053/comments/0/cofactors/0; /results/2053/comments/0/note""}, {""reference_id"": ""UniProtKB:P50107"", ""source_assertion"": ""UniProtKB:P50107 has the exact SGD cross-reference SGD:S000004463."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2053/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P50107"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P50107 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-901_cofactor-33012249bd91_9f6ed0e9ba49	SGD:S000005566	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12320	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The caution concerns identities of older glyoxalase preparations, not the current GLO4 zinc annotation; retain the explicit inference from a human homolog. UniProt evidence: ECO:0000250 (UniProtKB:Q16775) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:Q16775)	"[{""reference_id"": ""UniProtKB:Q12320"", ""source_assertion"": ""UniProtKB:Q12320 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3059/comments/0/cofactors/0; /results/3059/comments/0/note""}, {""reference_id"": ""UniProtKB:Q12320"", ""source_assertion"": ""UniProtKB:Q12320 has the exact SGD cross-reference SGD:S000005566."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3059/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q12320"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12320 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-001_cc52f920b8f8	CHEBI:17158	pathwaymech:consumes	RHEA:19071	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19069	Coefficient 1 in the selected physiological direction. Charge and stereochemistry follow the exact Rhea chemical; quinone/quinol nodes are corresponding substituted chemical classes, not a chain-length-specific pair.	"[{""reference_id"": ""RHEA:19069"", ""source_assertion"": ""RHEA:19071 substrates contain CHEBI:17158 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/19071 rh:substrates; http://rdf.rhea-db.org/19069_R rh:contains1 http://rdf.rhea-db.org/Participant_19069_compound_4547; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:19069"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 19069: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-002_147621c04b29	CHEBI:57925	pathwaymech:consumes	RHEA:19071	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19069	Coefficient 1 in the selected physiological direction. Charge and stereochemistry follow the exact Rhea chemical; quinone/quinol nodes are corresponding substituted chemical classes, not a chain-length-specific pair.	"[{""reference_id"": ""RHEA:19069"", ""source_assertion"": ""RHEA:19071 substrates contain CHEBI:57925 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/19071 rh:substrates; http://rdf.rhea-db.org/19069_R rh:contains1 http://rdf.rhea-db.org/Participant_19069_compound_4810; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:19069"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 19069: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-003_77ecfa8996f3	RHEA:19071	pathwaymech:produces	CHEBI:57474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19069	Coefficient 1 in the selected physiological direction. Charge and stereochemistry follow the exact Rhea chemical; quinone/quinol nodes are corresponding substituted chemical classes, not a chain-length-specific pair.	"[{""reference_id"": ""RHEA:19069"", ""source_assertion"": ""RHEA:19071 products contain CHEBI:57474 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/19071 rh:products; http://rdf.rhea-db.org/19069_L rh:contains1 http://rdf.rhea-db.org/Participant_19069_compound_1514; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:19069"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 19069: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-004_0592d3818b29	CHEBI:57474	pathwaymech:consumes	RHEA:25246	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25245	Coefficient 1 in the selected physiological direction. Charge and stereochemistry follow the exact Rhea chemical; quinone/quinol nodes are corresponding substituted chemical classes, not a chain-length-specific pair.	"[{""reference_id"": ""RHEA:25245"", ""source_assertion"": ""RHEA:25246 substrates contain CHEBI:57474 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25246 rh:substrates; http://rdf.rhea-db.org/25245_L rh:contains1 http://rdf.rhea-db.org/Participant_25245_compound_1514; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:25245"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 25245: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-005_f2543b541fdb	CHEBI:15377	pathwaymech:consumes	RHEA:25246	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25245	Coefficient 1 in the selected physiological direction. Charge and stereochemistry follow the exact Rhea chemical; quinone/quinol nodes are corresponding substituted chemical classes, not a chain-length-specific pair.	"[{""reference_id"": ""RHEA:25245"", ""source_assertion"": ""RHEA:25246 substrates contain CHEBI:15377 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25246 rh:substrates; http://rdf.rhea-db.org/25245_L rh:contains1 http://rdf.rhea-db.org/Participant_25245_compound_1283; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:25245"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 25245: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-006_f5d24dcb0545	RHEA:25246	pathwaymech:produces	CHEBI:16004	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25245	Coefficient 1 in the selected physiological direction. Charge and stereochemistry follow the exact Rhea chemical; quinone/quinol nodes are corresponding substituted chemical classes, not a chain-length-specific pair.	"[{""reference_id"": ""RHEA:25245"", ""source_assertion"": ""RHEA:25246 products contain CHEBI:16004 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25246 rh:products; http://rdf.rhea-db.org/25245_R rh:contains1 http://rdf.rhea-db.org/Participant_25245_compound_2842; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:25245"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 25245: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-007_58d336129e16	RHEA:25246	pathwaymech:produces	CHEBI:57925	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25245	Coefficient 1 in the selected physiological direction. Charge and stereochemistry follow the exact Rhea chemical; quinone/quinol nodes are corresponding substituted chemical classes, not a chain-length-specific pair.	"[{""reference_id"": ""RHEA:25245"", ""source_assertion"": ""RHEA:25246 products contain CHEBI:57925 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25246 rh:products; http://rdf.rhea-db.org/25245_R rh:contains1 http://rdf.rhea-db.org/Participant_25245_compound_4810; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:25245"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 25245: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-008_42f06bf24504	RHEA:25246	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25245	Coefficient 1 in the selected physiological direction. Charge and stereochemistry follow the exact Rhea chemical; quinone/quinol nodes are corresponding substituted chemical classes, not a chain-length-specific pair.	"[{""reference_id"": ""RHEA:25245"", ""source_assertion"": ""RHEA:25246 products contain CHEBI:15378 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25246 rh:products; http://rdf.rhea-db.org/25245_R rh:contains1 http://rdf.rhea-db.org/Participant_25245_compound_3249; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:25245"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 25245: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-009_cc71e23034b3	CHEBI:16004	pathwaymech:consumes	RHEA:51469	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51468	Coefficient 1 in the selected physiological direction. Charge and stereochemistry follow the exact Rhea chemical; quinone/quinol nodes are corresponding substituted chemical classes, not a chain-length-specific pair.	"[{""reference_id"": ""RHEA:51468"", ""source_assertion"": ""RHEA:51469 substrates contain CHEBI:16004 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/51469 rh:substrates; http://rdf.rhea-db.org/51468_L rh:contains1 http://rdf.rhea-db.org/Participant_51468_compound_2842; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:51468"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 51468: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-010_3029f440e74b	CHEBI:132124	pathwaymech:consumes	RHEA:51469	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51468	Coefficient 1 in the selected physiological direction. Charge and stereochemistry follow the exact Rhea chemical; quinone/quinol nodes are corresponding substituted chemical classes, not a chain-length-specific pair.	"[{""reference_id"": ""RHEA:51468"", ""source_assertion"": ""RHEA:51469 substrates contain CHEBI:132124 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/51469 rh:substrates; http://rdf.rhea-db.org/51468_L rh:contains1 http://rdf.rhea-db.org/Participant_51468_compound_13027; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:51468"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 51468: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-011_7bdee54c4113	RHEA:51469	pathwaymech:produces	CHEBI:24646	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51468	Coefficient 1 in the selected physiological direction. Charge and stereochemistry follow the exact Rhea chemical; quinone/quinol nodes are corresponding substituted chemical classes, not a chain-length-specific pair.	"[{""reference_id"": ""RHEA:51468"", ""source_assertion"": ""RHEA:51469 products contain CHEBI:24646 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/51469 rh:products; http://rdf.rhea-db.org/51468_R rh:contains1 http://rdf.rhea-db.org/Participant_51468_compound_13026; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:51468"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 51468: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-012_fc6668b57707	RHEA:51469	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51468	Coefficient 1 in the selected physiological direction. Charge and stereochemistry follow the exact Rhea chemical; quinone/quinol nodes are corresponding substituted chemical classes, not a chain-length-specific pair.	"[{""reference_id"": ""RHEA:51468"", ""source_assertion"": ""RHEA:51469 products contain CHEBI:15361 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/51469 rh:products; http://rdf.rhea-db.org/51468_R rh:contains1 http://rdf.rhea-db.org/Participant_51468_compound_3719; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:51468"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 51468: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-013_944f6449bd91	UniProtKB:P0AC81	BFO:0000050	MetaCyc:GLYOXI-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLYOXI-CPLX|MetaCyc:GLYOXI-MONOMER|PMID:9628737	Two GloA chains form the homodimer; subunit membership does not assert that an isolated chain catalyzes the net reaction.	"[{""reference_id"": ""MetaCyc:GLYOXI-CPLX"", ""source_assertion"": ""GLYOXI-CPLX contains GLYOXI-MONOMER with coefficient 2."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""GLYOXI-CPLX\""]/component[Protein/@frameid=\""GLYOXI-MONOMER\""]/coefficient""}, {""reference_id"": ""MetaCyc:GLYOXI-MONOMER"", ""source_assertion"": ""GLYOXI-MONOMER has an explicit UniProt unification cross-reference P0AC81."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""GLYOXI-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]""}, {""quote"": ""gel filtration analysis indicated GlxI to be a homodimer of 30 kDa."", ""reference_id"": ""PMID:9628737""}]"	"[{""id"": ""MetaCyc:GLYOXI-CPLX"", ""source_sha256"": ""5ba519e1ab67d57aa28f7e64770a6d68bcd2b3877f828246e74613aacc324f04"", ""source_version"": ""MetaCyc 22.5; native XML retrieved 2026-10-11 UTC"", ""title"": ""glyoxalase I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GLYOXI-CPLX""}, {""id"": ""MetaCyc:GLYOXI-MONOMER"", ""source_sha256"": ""0cd1f7ab34b314eff314d1411eb8ebd1260baa75c8104239c0f972a2fff71b44"", ""source_version"": ""MetaCyc 22.5; native XML retrieved 2026-10-11 UTC"", ""title"": ""glyoxalase I subunit"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GLYOXI-MONOMER""}, {""id"": ""PMID:9628737"", ""source_sha256"": ""035d5dcc535259902b93994cab8ab347eb5677a9b0f4950d3a46326c29747fbf"", ""source_version"": ""Europe PMC indexed primary abstract/metadata response retrieved 2026-10-11 UTC; not publisher full text"", ""title"": ""Overproduction and characterization of a dimeric non-zinc glyoxalase I from Escherichia coli: evidence for optimal activation by nickel ions."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9628737/""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-014_c1ade77ba587	MetaCyc:GLYOXI-CPLX	pathwaymech:catalyzes	RHEA:19071	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLYOXI-CPLX|PathBank:SMP0002125|RHEA:19069|UniProtKB:P0AC81	GloA isomerizes the hemithioacetal formed spontaneously from methylglyoxal and glutathione. The Rhea net equation folds the preceding spontaneous equilibrium into the conversion; it is not evidence that GloA catalyzes initial condensation.	"[{""reference_id"": ""MetaCyc:GLYOXI-CPLX"", ""source_assertion"": ""The complex catalyzes GLYOXI-ENZRXN, whose reaction is GLYOXI-RXN."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""GLYOXI-CPLX\""]/catalyzes/Enzymatic-Reaction[@frameid=\""GLYOXI-ENZRXN\""]""}, {""reference_id"": ""UniProtKB:P0AC81"", ""source_assertion"": ""FUNCTION specifies spontaneous hemithioacetal formation followed by GloA isomerization; catalytic annotation names RHEA:19069 with ECO:0000269/PMID10913283."", ""source_locator"": ""/comments/0; /comments/1/reaction""}, {""reference_id"": ""RHEA:19069"", ""source_assertion"": ""RHEA:19071 is the right-to-left directional member of master RHEA:19069, producing (R)-S-lactoylglutathione."", ""source_locator"": ""http://rdf.rhea-db.org/19069 rh:directionalReaction; http://rdf.rhea-db.org/19071 rh:substrates/rh:products""}, {""reference_id"": ""PathBank:SMP0002125"", ""source_assertion"": ""Native ReactionCatalysis/6107 assigns glyoxalase I complex ProteinComplex/4108 to Reactions/6149; the complex contains two Protein/6205 chains, whose reference identifies P0AC81."", ""source_locator"": ""PW002113.owl#ReactionCatalysis/6107; #ProteinComplex/4108; #Protein/6205/Stoichiometry/2.0; #ProteinReference/6205""}]"	"[{""id"": ""MetaCyc:GLYOXI-CPLX"", ""source_sha256"": ""5ba519e1ab67d57aa28f7e64770a6d68bcd2b3877f828246e74613aacc324f04"", ""source_version"": ""MetaCyc 22.5; native XML retrieved 2026-10-11 UTC"", ""title"": ""glyoxalase I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GLYOXI-CPLX""}, {""id"": ""PathBank:SMP0002125"", ""source_sha256"": ""4acbf2083dba4aa1be7bdd7a1b5e11f7d93694fa919e56a0f6b0fdc104b32193"", ""source_version"": ""Primary archive Last-Modified 2019-08-16; SHA256 covers member PW002113.owl, not ZIP"", ""title"": ""Methylglyoxal Degradation I"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:19069"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 19069: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0AC81"", ""source_sha256"": ""45b8af31cd9ff71ebaa84bdace95022b9105f21de9d8bc6efe7fcdfc81035740"", ""source_version"": ""UniProt 2026_03, release date 2026-09-02; full JSON retrieved 2026-10-11 UTC"", ""title"": ""Lactoylglutathione lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AC81.json""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-015_51cf302a9bbe	UniProtKB:P0AC84	pathwaymech:catalyzes	RHEA:25246	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:17196158|PMID:25670698|PathBank:SMP0002125|RHEA:25245|UniProtKB:P0AC84	Monomeric GloB hydrolyzes the R-specific thioester. This is the source map’s GloB branch; GloC provides an experimentally supported accessory isoenzyme but is not required to invent an additional chemical step.	"[{""reference_id"": ""UniProtKB:P0AC84"", ""source_assertion"": ""The specific (R)-S-lactoylglutathione hydrolysis is RHEA:25245 (ECO:0000269/PMID17196158,25670698); SUBUNIT says monomer (ECO:0000269/PMID17196158)."", ""source_locator"": ""/comments/2/reaction; /comments/7""}, {""reference_id"": ""RHEA:25245"", ""source_assertion"": ""RHEA:25246 is the left-to-right directional member of RHEA:25245."", ""source_locator"": ""http://rdf.rhea-db.org/25245 rh:directionalReaction; http://rdf.rhea-db.org/25246 rh:substrates/rh:products""}, {""quote"": ""Glyoxalase II (Glx II) hydrolyzes the thioester into d-lactate and free glutathione."", ""reference_id"": ""PMID:17196158""}, {""reference_id"": ""PathBank:SMP0002125"", ""source_assertion"": ""Native ReactionCatalysis/6108 assigns Protein/6206 (UniProt P0AC84) to Reactions/6150. Its L-lactate label/xref is contradicted by the independently inspected R-specific enzyme chemistry."", ""source_locator"": ""PW002113.owl#ReactionCatalysis/6108; #ProteinReference/6206; #Reactions/6150; #CompoundReference/PW_C000122""}, {""quote"": ""The two isoenzymes have additive effects and ensure maximal MG degradation."", ""reference_id"": ""PMID:25670698""}]"	"[{""id"": ""PMID:17196158"", ""source_sha256"": ""5db1a0aa36cf6100e39b8aa40047521371854a22947b3e8970130646e4ca071a"", ""source_version"": ""Europe PMC indexed primary abstract/metadata response retrieved 2026-10-11 UTC; not publisher full text"", ""title"": ""Escherichia coli glyoxalase II is a binuclear zinc-dependent metalloenzyme."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/17196158/""}, {""id"": ""PMID:25670698"", ""source_sha256"": ""a2fc2b0206d1578ea60e8390bfa46bbdb1fa8ba1aeeafb645f1107f45788655a"", ""source_version"": ""Europe PMC indexed primary abstract/metadata response retrieved 2026-10-11 UTC; not publisher full text"", ""title"": ""Deciphering the role of the type II glyoxalase isoenzyme YcbL (GlxII-2) in Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/25670698/""}, {""id"": ""PathBank:SMP0002125"", ""source_sha256"": ""4acbf2083dba4aa1be7bdd7a1b5e11f7d93694fa919e56a0f6b0fdc104b32193"", ""source_version"": ""Primary archive Last-Modified 2019-08-16; SHA256 covers member PW002113.owl, not ZIP"", ""title"": ""Methylglyoxal Degradation I"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:25245"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 25245: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0AC84"", ""source_sha256"": ""cb45f73fafd008ac848b645ca5e13883803feb767179f78d92540540cdee9f7c"", ""source_version"": ""UniProt 2026_03, release date 2026-09-02; full JSON retrieved 2026-10-11 UTC"", ""title"": ""Hydroxyacylglutathione hydrolase GloB"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AC84.json""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-016_9e6148f11883	UniProtKB:P06149	pathwaymech:catalyzes	RHEA:51469	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:3013300|PathBank:SMP0002125|RHEA:51468|UniProtKB:P06149	Respiratory Dld oxidizes D-(R)-lactate using enzyme-bound FAD and a quinone acceptor. The generic Rhea class is faithful to current annotation; no UQ6 specificity, NAD dependence or direct proton pumping by Dld is inferred. The inspected 1986 reconstitution used ubiquinone-8; its electron-transfer step was not electrogenic.	"[{""reference_id"": ""UniProtKB:P06149"", ""source_assertion"": ""Dld catalytic annotation names RHEA:51468: (R)-lactate + a quinone = a quinol + pyruvate; ECO:0000269/PMID3013300,7578233 and ECO:0000255/HAMAP MF_02092."", ""source_locator"": ""/comments/1/reaction""}, {""reference_id"": ""RHEA:51468"", ""source_assertion"": ""RHEA:51469 is the left-to-right directional member of RHEA:51468, using the exact ChEBI quinone and quinol classes."", ""source_locator"": ""http://rdf.rhea-db.org/51468 rh:directionalReaction; http://rdf.rhea-db.org/51469 rh:substrates/rh:products""}, {""reference_id"": ""PathBank:SMP0002125"", ""source_assertion"": ""Native ReactionCatalysis/6109 assigns Protein/5893 (UniProt P06149) to Reactions/6151. The L-lactate and UQ6 assignments are not imported as exact Rhea equivalences."", ""source_locator"": ""PW002113.owl#ReactionCatalysis/6109; #ProteinReference/5893; #Reactions/6151""}, {""quote"": ""proteoliposomes reconstituted with purified D-lactate dehydrogenase, ubiquinone 8, and purified cytochrome o"", ""reference_id"": ""PMID:3013300""}]"	"[{""id"": ""PMID:3013300"", ""source_sha256"": ""9716a91b72ccbc8e0e86334087d0436db715b9a4011bc847f01b51663262147a"", ""source_version"": ""Europe PMC indexed primary abstract/metadata response retrieved 2026-10-11 UTC; not publisher full text; source abstract truncated at 250 words"", ""title"": ""D-lactate oxidation and generation of the proton electrochemical gradient in membrane vesicles from Escherichia coli GR19N and in proteoliposomes reconstituted with purified D-lactate dehydrogenase and cytochrome o oxidase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/3013300/""}, {""id"": ""PathBank:SMP0002125"", ""source_sha256"": ""4acbf2083dba4aa1be7bdd7a1b5e11f7d93694fa919e56a0f6b0fdc104b32193"", ""source_version"": ""Primary archive Last-Modified 2019-08-16; SHA256 covers member PW002113.owl, not ZIP"", ""title"": ""Methylglyoxal Degradation I"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:51468"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 51468: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P06149"", ""source_sha256"": ""60f583cad209142f1903bf985c55046590561c1e6d2ef7330e9d49bdd989ffcb"", ""source_version"": ""UniProt 2026_03, release date 2026-09-02; full JSON retrieved 2026-10-11 UTC"", ""title"": ""Quinone-dependent D-lactate dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06149.json""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-017_9a52d8ebec95	MetaCyc:GLYOXI-CPLX	pathwaymech:has_cofactor	CHEBI:49786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:10913283|PMID:9628737|UniProtKB:P0AC81	Ni2+ activates E. coli GloA, whereas Zn2+ does not. Current annotation of the 2000 structures reports one Ni per subunit/two per dimer; the 1998 solution study reported one Ni per dimer. These are differing measurements, not a universal physiological occupancy. Co2+ and Cd2+ also activated protein-metal complexes in the structural study.	"[{""reference_id"": ""UniProtKB:P0AC81"", ""source_assertion"": ""COFACTOR: Ni2+ (ECO:0000269/PMID10913283); note reports one nickel per subunit/two between dimer subunits and inactivity with Zn2+."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}, {""quote"": ""the Escherichia coli enzyme is inactive in the presence of Zn(2+) and is maximally active with Ni(2+)."", ""reference_id"": ""PMID:10913283""}, {""reference_id"": ""PMID:9628737"", ""source_assertion"": ""The indexed abstract reports one nickel ion per dimeric enzyme by inductively coupled plasma and atomic absorption analyses; this differs from the later structured annotation."", ""source_locator"": ""/resultList/result[0]/abstractText, metal-analysis sentences""}]"	"[{""id"": ""PMID:10913283"", ""source_sha256"": ""8f5b4fc79cb48e8bc231dc75091cee265d896f66ab260b615e5e1e170f0d5688"", ""source_version"": ""Europe PMC indexed primary abstract/metadata response retrieved 2026-10-11 UTC; not publisher full text"", ""title"": ""Determination of the structure of Escherichia coli glyoxalase I suggests a structural basis for differential metal activation."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/10913283/""}, {""id"": ""PMID:9628737"", ""source_sha256"": ""035d5dcc535259902b93994cab8ab347eb5677a9b0f4950d3a46326c29747fbf"", ""source_version"": ""Europe PMC indexed primary abstract/metadata response retrieved 2026-10-11 UTC; not publisher full text"", ""title"": ""Overproduction and characterization of a dimeric non-zinc glyoxalase I from Escherichia coli: evidence for optimal activation by nickel ions."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9628737/""}, {""id"": ""UniProtKB:P0AC81"", ""source_sha256"": ""45b8af31cd9ff71ebaa84bdace95022b9105f21de9d8bc6efe7fcdfc81035740"", ""source_version"": ""UniProt 2026_03, release date 2026-09-02; full JSON retrieved 2026-10-11 UTC"", ""title"": ""Lactoylglutathione lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AC81.json""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-018_cb1c1e2dbaa3	UniProtKB:P0AC84	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AC84	Current annotation reports two Zn2+ ions per GloB monomer. Mn2+ and Co2+ substitute in reconstitution experiments; this is not a claim of in vivo metal substitution. Neither GloA nickel dependence nor other organisms’ mixed metals are transferred to GloB.	"[{""reference_id"": ""UniProtKB:P0AC84"", ""source_assertion"": ""GloB binds two Zn2+ ions per subunit (ECO:0000269/PMID17196158); Mn2+ and Co2+ can replace zinc in reconstitution experiments."", ""source_locator"": ""/comments/3/cofactors; /comments/3/note""}]"	"[{""id"": ""UniProtKB:P0AC84"", ""source_sha256"": ""cb45f73fafd008ac848b645ca5e13883803feb767179f78d92540540cdee9f7c"", ""source_version"": ""UniProt 2026_03, release date 2026-09-02; full JSON retrieved 2026-10-11 UTC"", ""title"": ""Hydroxyacylglutathione hydrolase GloB"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AC84.json""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-019_1dab81a3eff5	UniProtKB:P06149	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:10944213|UniProtKB:P06149	FAD is bound to Dld and cycles redox state during turnover; it is not a freely consumed substrate in the net quinone reaction. The ChEBI charge state follows current UniProt grounding.	"[{""reference_id"": ""UniProtKB:P06149"", ""source_assertion"": ""COFACTOR identifies FAD/CHEBI:57692 with experimental support from PMID10944213,4575624,4582730,7578233, alongside HAMAP inference."", ""source_locator"": ""/comments/2/cofactors""}, {""quote"": ""a noncovalently bound FAD cofactor"", ""reference_id"": ""PMID:10944213""}]"	"[{""id"": ""PMID:10944213"", ""source_sha256"": ""cfdbd6444a83c415b84af14a485f5b84d12bbeeee5f112df53f2b5095ab14683"", ""source_version"": ""Europe PMC indexed primary abstract/metadata response retrieved 2026-10-11 UTC; not publisher full text"", ""title"": ""The crystal structure of D-lactate dehydrogenase, a peripheral membrane respiratory enzyme."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/10944213/""}, {""id"": ""UniProtKB:P06149"", ""source_sha256"": ""60f583cad209142f1903bf985c55046590561c1e6d2ef7330e9d49bdd989ffcb"", ""source_version"": ""UniProt 2026_03, release date 2026-09-02; full JSON retrieved 2026-10-11 UTC"", ""title"": ""Quinone-dependent D-lactate dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06149.json""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-020_96b2b83b7566	UniProtKB:P06149	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:10944213|UniProtKB:P06149	Dld is a peripheral enzyme on the cytoplasmic side of the E. coli inner (plasma) membrane. The edge does not encode integral topology or a universal location for the whole pathway.	"[{""reference_id"": ""UniProtKB:P06149"", ""source_assertion"": ""SUBCELLULAR LOCATION: cell inner membrane, peripheral membrane protein, cytoplasmic side; experimental citations include PMID1092688,4575624,4582730 alongside HAMAP."", ""source_locator"": ""/comments/5/subcellularLocations/0""}, {""quote"": ""located on the cytoplasmic side of the inner membrane"", ""reference_id"": ""PMID:10944213""}]"	"[{""id"": ""PMID:10944213"", ""source_sha256"": ""cfdbd6444a83c415b84af14a485f5b84d12bbeeee5f112df53f2b5095ab14683"", ""source_version"": ""Europe PMC indexed primary abstract/metadata response retrieved 2026-10-11 UTC; not publisher full text"", ""title"": ""The crystal structure of D-lactate dehydrogenase, a peripheral membrane respiratory enzyme."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/10944213/""}, {""id"": ""UniProtKB:P06149"", ""source_sha256"": ""60f583cad209142f1903bf985c55046590561c1e6d2ef7330e9d49bdd989ffcb"", ""source_version"": ""UniProt 2026_03, release date 2026-09-02; full JSON retrieved 2026-10-11 UTC"", ""title"": ""Quinone-dependent D-lactate dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06149.json""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-021_0f73f6c1f4ba	RHEA:19071	BFO:0000050	MetaCyc:PWY-5386	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLYOXI-RXN|MetaCyc:PWY-5386|RHEA:19069	Native reaction membership plus an independently grounded selected Rhea direction. The Dld bridge uses matching catalyst and chemistry, not a fabricated exact-match cross-reference.	"[{""reference_id"": ""MetaCyc:PWY-5386"", ""source_assertion"": ""PWY-5386 explicitly lists GLYOXI-RXN; its reaction-layout selects R2L."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-5386\""]/reaction-list; reaction-layout[Reaction/@frameid=\""GLYOXI-RXN\""]""}, {""reference_id"": ""MetaCyc:GLYOXI-RXN"", ""source_assertion"": ""GLYOXI-RXN has native Rhea unification cross-reference 19072; this is the bidirectional family member, not the selected directed accession."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""GLYOXI-RXN\""]/dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:19069"", ""source_assertion"": ""Master RHEA:19069 explicitly has bidirectionalReaction RHEA:19072 and directionalReaction RHEA:19071."", ""source_locator"": ""http://rdf.rhea-db.org/19069 rh:bidirectionalReaction http://rdf.rhea-db.org/19072; rh:directionalReaction http://rdf.rhea-db.org/19071""}]"	"[{""id"": ""MetaCyc:GLYOXI-RXN"", ""source_sha256"": ""6a7a1b978ba143de4326aaea171f1ffaf14f52bb5506db8825a084248a8a1d31"", ""source_version"": ""MetaCyc 22.5; native XML retrieved 2026-10-11 UTC"", ""title"": ""lactoylglutathione lyase reaction"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GLYOXI-RXN""}, {""id"": ""MetaCyc:PWY-5386"", ""source_sha256"": ""00ff04c1d2806dfa130b6f17082ed158a762b771d5955112927dec4730c8a918"", ""source_version"": ""MetaCyc 22.5; native XML retrieved 2026-10-11 UTC"", ""title"": ""methylglyoxal degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5386""}, {""id"": ""RHEA:19069"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 19069: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-022_17543d04025d	RHEA:25246	BFO:0000050	MetaCyc:PWY-5386	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLYOXII-RXN|MetaCyc:PWY-5386|RHEA:25245	Native reaction membership plus an independently grounded selected Rhea direction. The Dld bridge uses matching catalyst and chemistry, not a fabricated exact-match cross-reference.	"[{""reference_id"": ""MetaCyc:PWY-5386"", ""source_assertion"": ""PWY-5386 explicitly lists GLYOXII-RXN; its reaction-layout selects L2R."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-5386\""]/reaction-list; reaction-layout[Reaction/@frameid=\""GLYOXII-RXN\""]""}, {""reference_id"": ""MetaCyc:GLYOXII-RXN"", ""source_assertion"": ""GLYOXII-RXN has native Rhea unification cross-reference 25245; this is the master, not the selected directed accession."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""GLYOXII-RXN\""]/dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:25245"", ""source_assertion"": ""Master RHEA:25245 explicitly has directionalReaction RHEA:25246."", ""source_locator"": ""http://rdf.rhea-db.org/25245 rh:directionalReaction http://rdf.rhea-db.org/25246""}]"	"[{""id"": ""MetaCyc:GLYOXII-RXN"", ""source_sha256"": ""d1805c8958b7e0bdc1e2a0ce520efdb1a14afc556aee7213d5d892eae93f8594"", ""source_version"": ""MetaCyc 22.5; native XML retrieved 2026-10-11 UTC"", ""title"": ""hydroxyacylglutathione hydrolase reaction"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GLYOXII-RXN""}, {""id"": ""MetaCyc:PWY-5386"", ""source_sha256"": ""00ff04c1d2806dfa130b6f17082ed158a762b771d5955112927dec4730c8a918"", ""source_version"": ""MetaCyc 22.5; native XML retrieved 2026-10-11 UTC"", ""title"": ""methylglyoxal degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5386""}, {""id"": ""RHEA:25245"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 25245: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-023_0a195a2f9100	RHEA:51469	BFO:0000050	MetaCyc:PWY-5386	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DLACTDEHYDROGFAD-RXN|MetaCyc:PWY-5386|RHEA:51468|UniProtKB:P06149	Native reaction membership plus an independently grounded selected Rhea direction. The Dld bridge uses matching catalyst and chemistry, not a fabricated exact-match cross-reference.	"[{""reference_id"": ""MetaCyc:PWY-5386"", ""source_assertion"": ""PWY-5386 explicitly lists DLACTDEHYDROGFAD-RXN; its reaction-layout selects L2R."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-5386\""]/reaction-list; reaction-layout[Reaction/@frameid=\""DLACTDEHYDROGFAD-RXN\""]""}, {""reference_id"": ""MetaCyc:DLACTDEHYDROGFAD-RXN"", ""source_assertion"": ""Native reaction consumes D-LACTATE and Ubiquinones, producing PYRUVATE and Ubiquinols; it has no explicit Rhea dblink."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""DLACTDEHYDROGFAD-RXN\""]/left; /right""}, {""reference_id"": ""UniProtKB:P06149"", ""source_assertion"": ""The native Dld controller P06149 is independently assigned RHEA:51468; the current Rhea reaction uses broader quinone/quinol classes."", ""source_locator"": ""/comments/1/reaction; /uniProtKBCrossReferences[database=\""BioCyc\""]""}, {""reference_id"": ""RHEA:51468"", ""source_assertion"": ""Master RHEA:51468 explicitly has directionalReaction RHEA:51469."", ""source_locator"": ""http://rdf.rhea-db.org/51468 rh:directionalReaction http://rdf.rhea-db.org/51469""}]"	"[{""id"": ""MetaCyc:DLACTDEHYDROGFAD-RXN"", ""source_sha256"": ""d65dae1c6dd8d365c188b805c26016db5b9ba08893ac5dcb89fb02433208f33c"", ""source_version"": ""MetaCyc 22.5; native XML retrieved 2026-10-11 UTC"", ""title"": ""D-lactate dehydrogenase reaction"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DLACTDEHYDROGFAD-RXN""}, {""id"": ""MetaCyc:PWY-5386"", ""source_sha256"": ""00ff04c1d2806dfa130b6f17082ed158a762b771d5955112927dec4730c8a918"", ""source_version"": ""MetaCyc 22.5; native XML retrieved 2026-10-11 UTC"", ""title"": ""methylglyoxal degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5386""}, {""id"": ""RHEA:51468"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 51468: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P06149"", ""source_sha256"": ""60f583cad209142f1903bf985c55046590561c1e6d2ef7330e9d49bdd989ffcb"", ""source_version"": ""UniProt 2026_03, release date 2026-09-02; full JSON retrieved 2026-10-11 UTC"", ""title"": ""Quinone-dependent D-lactate dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P06149.json""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-024_7a8396ba7de2	RHEA:19071	RO:0002413	RHEA:25246	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19069|RHEA:25245|UniProtKB:P0AC84	The R-specific lactoylglutathione product is the GloB substrate; glutathione is regenerated by hydrolysis.	"[{""reference_id"": ""RHEA:19069"", ""source_assertion"": ""RHEA:19071 produces CHEBI:57474."", ""source_locator"": ""http://rdf.rhea-db.org/19071 rh:products; http://rdf.rhea-db.org/19069_L rh:contains1""}, {""reference_id"": ""RHEA:25245"", ""source_assertion"": ""RHEA:25246 consumes CHEBI:57474 and produces CHEBI:57925."", ""source_locator"": ""http://rdf.rhea-db.org/25246 rh:substrates/rh:products""}, {""reference_id"": ""UniProtKB:P0AC84"", ""source_assertion"": ""FUNCTION identifies the hydrolysis of (R)-S-lactoylglutathione to (R)-lactate and glutathione, with ECO:0000269 primary citations."", ""source_locator"": ""/comments/0""}]"	"[{""id"": ""RHEA:19069"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 19069: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:25245"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 25245: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0AC84"", ""source_sha256"": ""cb45f73fafd008ac848b645ca5e13883803feb767179f78d92540540cdee9f7c"", ""source_version"": ""UniProt 2026_03, release date 2026-09-02; full JSON retrieved 2026-10-11 UTC"", ""title"": ""Hydroxyacylglutathione hydrolase GloB"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AC84.json""}]"	""
pathwaymech:MetaCyc_PWY-5386_mg1-edge-025_bc66ef2deddd	RHEA:25246	RO:0002413	RHEA:51469	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:37850128|RHEA:25245|RHEA:51468	GloB-derived D-lactate feeds Dld oxidation to pyruvate. The 2022 physiological test used MG1655-derived SIJ488 glycolysis mutants on glycerol; it does not prove identical basal flux in every K-12 condition or GloB exclusivity over GloC.	"[{""reference_id"": ""RHEA:25245"", ""source_assertion"": ""RHEA:25246 produces CHEBI:16004, the R-specific lactate."", ""source_locator"": ""http://rdf.rhea-db.org/25246 rh:products; http://rdf.rhea-db.org/25245_R rh:contains1""}, {""reference_id"": ""RHEA:51468"", ""source_assertion"": ""RHEA:51469 consumes CHEBI:16004 and produces pyruvate."", ""source_locator"": ""http://rdf.rhea-db.org/51469 rh:substrates/rh:products""}, {""quote"": ""the absence of GloA or Dld completely abolished growth on glycerol"", ""reference_id"": ""PMID:37850128""}]"	"[{""id"": ""PMID:37850128"", ""source_sha256"": ""b589694256fb3da774f5d71bd56b10bcefef06ea74772d22e1cb0e20ffe3480d"", ""source_version"": ""Published 2022, DOI 10.34133/2022/9859643; Europe PMC full-text JATS retrieved 2026-10-11 UTC"", ""title"": ""Activating Silent Glycolysis Bypasses in Escherichia coli"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10521649/fullTextXML""}, {""id"": ""RHEA:25245"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 25245: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:51468"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 (2026-09-02); SHA256 covers full compressed RDF, selected subjects retained in research projection"", ""title"": ""Rhea 51468: reaction family and selected direction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5453_mg3-edge-001_49c2cfb9f6e0	CHEBI:17158	pathwaymech:consumes	RHEA:27988	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27988		"[{""reference_id"": ""RHEA:27988"", ""source_assertion"": ""Rhea RHEA:27988 assigns CHEBI:17158 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27988']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27986_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27986_compound_4547']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27988"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27988 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5453_mg3-edge-002_e0941e9db6a5	CHEBI:57783	pathwaymech:consumes	RHEA:27988	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27988		"[{""reference_id"": ""RHEA:27988"", ""source_assertion"": ""Rhea RHEA:27988 assigns CHEBI:57783 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27988']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27986_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27986_compound_3438']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27988"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27988 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5453_mg3-edge-003_4984032c34b2	CHEBI:15378	pathwaymech:consumes	RHEA:27988	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27988		"[{""reference_id"": ""RHEA:27988"", ""source_assertion"": ""Rhea RHEA:27988 assigns CHEBI:15378 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27988']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27986_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27986_compound_3249']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27988"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27988 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5453_mg3-edge-004_951888e47061	RHEA:27988	pathwaymech:produces	CHEBI:27957	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27988		"[{""reference_id"": ""RHEA:27988"", ""source_assertion"": ""Rhea RHEA:27988 assigns CHEBI:27957 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27988']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27986_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27986_compound_6312']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27988"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27988 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5453_mg3-edge-005_1652d573e28f	RHEA:27988	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27988		"[{""reference_id"": ""RHEA:27988"", ""source_assertion"": ""Rhea RHEA:27988 assigns CHEBI:58349 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27988']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27986_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27986_compound_5188']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27988"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27988 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5453_mg3-edge-006_b9b6fd3f1285	CHEBI:27957	pathwaymech:consumes	RHEA:28668	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28668		"[{""reference_id"": ""RHEA:28668"", ""source_assertion"": ""Rhea RHEA:28668 assigns CHEBI:27957 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28668']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28667_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28667_compound_6312']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28668"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28668 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5453_mg3-edge-007_444aa3594289	CHEBI:57945	pathwaymech:consumes	RHEA:28668	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28668		"[{""reference_id"": ""RHEA:28668"", ""source_assertion"": ""Rhea RHEA:28668 assigns CHEBI:57945 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28668']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28667_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28667_compound_1650']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28668"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28668 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5453_mg3-edge-008_b2390813fb3f	CHEBI:15378	pathwaymech:consumes	RHEA:28668	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28668		"[{""reference_id"": ""RHEA:28668"", ""source_assertion"": ""Rhea RHEA:28668 assigns CHEBI:15378 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28668']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28667_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28667_compound_3249']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28668"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28668 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5453_mg3-edge-009_859f3271e4d8	RHEA:28668	pathwaymech:produces	CHEBI:29002	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28668	The (S) product is the current Rhea/UniProt and native pathway annotation. The inspected 2005 NMR study did not resolve diol enantiomers. Engineered AG1 R-diol production in PMID:10049880 was assigned to a lactaldehyde route and does not directly test this exact GldA acetol step.	"[{""reference_id"": ""RHEA:28668"", ""source_assertion"": ""Rhea RHEA:28668 assigns CHEBI:29002 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28668']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28667_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28667_compound_5131']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28668"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28668 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5453_mg3-edge-010_db928ca0cd54	RHEA:28668	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28668		"[{""reference_id"": ""RHEA:28668"", ""source_assertion"": ""Rhea RHEA:28668 assigns CHEBI:57540 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28668']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28667_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28667_compound_3484']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28668"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28668 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5453_mg3-edge-011_2bb62597fe8d	UniProtKB:Q46851	pathwaymech:enables	RHEA:27988	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:16077126|UniProtKB:Q46851	Functional Gpr/YghZ activity is represented without asserting a monomeric physical catalyst. Current UniProt reports tetrameric and octameric assemblies in different studies. Its methylglyoxal activity is much less efficient than its L-glyceraldehyde 3-phosphate reductase activity; this is not an exclusive substrate or physiological-role claim.	"[{""reference_id"": ""PMID:16077126"", ""source_assertion"": ""Purified YghZ converts methylglyoxal to acetol with NADPH by NMR. NADH activity was below 3% of NADPH activity; the reverse acetol-to-methylglyoxal reaction was not detected under the assay conditions."", ""source_locator"": ""PMC1196063: Results, Reduction of methylglyoxal to acetol by purified E. coli AKRs; Figure 3B; Table 2""}, {""reference_id"": ""UniProtKB:Q46851"", ""source_assertion"": ""Reviewed Q46851 assigns hydroxyacetone/NADP versus methylglyoxal/NADPH chemistry to RHEA:27986, citing ECO:0000269 PMID:16077126 and ECO:0000305 PMID:12583903."", ""source_locator"": ""/comments/2/reaction; /genes/0; /primaryAccession""}]"	"[{""id"": ""PMID:16077126"", ""source_sha256"": ""7edca4dd5ce4a7ab4903200f3bacbdbc3d35a276cc7a241e7cecd4d3992cd574"", ""source_version"": ""Primary full text; retrieved 2026-10-10"", ""title"": ""Conversion of methylglyoxal to acetol by Escherichia coli aldo-keto reductases."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1196063/?pdf=render""}, {""id"": ""UniProtKB:Q46851"", ""source_sha256"": ""b42926fbe3b36065ea7e2ebe7e67c6d787b7be9ae2edf95187f20fd4b95e126e"", ""source_version"": ""2026_03; response release header and entry retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB Q46851"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q46851.json""}]"	""
pathwaymech:MetaCyc_PWY-5453_mg3-edge-012_2c082840d13e	MetaCyc:GLYCDEH-CPLX	pathwaymech:catalyzes	RHEA:28668	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-8632|UniProtKB:P0A9S5	The (S) product is the current Rhea/UniProt and native pathway annotation. The inspected 2005 NMR study did not resolve diol enantiomers. Engineered AG1 R-diol production in PMID:10049880 was assigned to a lactaldehyde route and does not directly test this exact GldA acetol step. This retains a reviewed enzyme-function assertion; the cited older experiments were not all inspected as full texts. NADH is the selected branch, not a claim that no NADPH-supported activity exists.	"[{""reference_id"": ""MetaCyc:RXN-8632"", ""source_assertion"": ""RXN-8632 has ENZRXN0-6324 with GLYCDEH-CPLX as enzyme, a RHEA:28667 cross-reference and acetol/NADH/proton opposite (S)-propane-1,2-diol/NAD. PWY-5453 selects the reduction direction."", ""source_locator"": ""Reaction[@frameid=\""RXN-8632\""]/enzymatic-reaction/Enzymatic-Reaction[@frameid=\""ENZRXN0-6324\""]/enzyme; left; right; dblink""}, {""reference_id"": ""UniProtKB:P0A9S5"", ""source_assertion"": ""Reviewed GldA explicitly assigns hydroxyacetone + NADH + H(+) = (S)-propane-1,2-diol + NAD(+) to RHEA:28667, with ECO:0000269 citations 18179582,3920199,40950,6365902."", ""source_locator"": ""/comments/2/reaction; /primaryAccession""}]"	"[{""id"": ""MetaCyc:RXN-8632"", ""source_sha256"": ""c7366709561952a9ed759276b844325c2b0c5f4a54a8e30928123c671bcd11d6"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc RXN-8632"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8632""}, {""id"": ""UniProtKB:P0A9S5"", ""source_sha256"": ""faee284ee8a8c21d95764d891e90e9154d22c2fda5c891c59f0d890ffb577a49"", ""source_version"": ""2026_03; response release header and entry retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P0A9S5"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9S5.json""}]"	""
pathwaymech:MetaCyc_PWY-5453_mg3-edge-013_e74714501def	UniProtKB:P0A9S5	BFO:0000050	MetaCyc:GLYCDEH-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLYCDEH-CPLX|MetaCyc:GLYCDEH-MONOMER|PMID:30839292	The native octamer coefficient is condition-dependent. This edge records component membership only; it does not assert that all catalysis requires an octamer or excludes tetramers/dimers.	"[{""reference_id"": ""MetaCyc:GLYCDEH-CPLX"", ""source_assertion"": ""GLYCDEH-CPLX contains GLYCDEH-MONOMER with coefficient 8 and explicitly notes an active dimer. This supports membership without an invariant assembly stoichiometry."", ""source_locator"": ""Protein[@frameid=\""GLYCDEH-CPLX\""]/component; comment""}, {""reference_id"": ""MetaCyc:GLYCDEH-MONOMER"", ""source_assertion"": ""The native GLYCDEH-MONOMER has the exact UniProt cross-reference P0A9S5."", ""source_locator"": ""Protein[@frameid=\""GLYCDEH-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}, {""reference_id"": ""PMID:30839292"", ""source_assertion"": ""Purified E. coli GldA eluted as a homogeneous tetramer in 5% glycerol; the authors contrast reported dimer/octamer mixtures without glycerol."", ""source_locator"": ""PMC6404857: Results and discussion 3.1, Protein purification; Figure 1b""}]"	"[{""id"": ""MetaCyc:GLYCDEH-CPLX"", ""source_sha256"": ""8f0f6b3c38dbb2084640908e907ab4ac7ff90ac8edb741f766f72202a6f1f5f3"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc GLYCDEH-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GLYCDEH-CPLX""}, {""id"": ""MetaCyc:GLYCDEH-MONOMER"", ""source_sha256"": ""e0a12822cfb2df8e66728d61b9a1006bc37f73edfa64e6bf1d3167be384bcad8"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc GLYCDEH-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GLYCDEH-MONOMER""}, {""id"": ""PMID:30839292"", ""source_sha256"": ""40df653530af56649dbfb283428b1e8d9fce15b945ce649c1db8ae7223e0e53e"", ""source_version"": ""Primary full text; retrieved 2026-10-10"", ""title"": ""Structure of glycerol dehydrogenase (GldA) from Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC6404857/?pdf=render""}]"	""
pathwaymech:MetaCyc_PWY-5453_mg3-edge-014_8ba3b2fc5d06	UniProtKB:P0A9S5	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:30839292|UniProtKB:P0A9S5	The crystal demonstrates bound zinc; it is not an apo-enzyme metal-reconstitution assay for acetol reduction. NAD+ in the 2019 structural illustration was modeled from another structure, not observed in that crystal.	"[{""reference_id"": ""UniProtKB:P0A9S5"", ""source_assertion"": ""Reviewed GldA names Zn(2+) as cofactor with ECO:0000305 PMID:30839292; its note says one zinc ion per subunit with ECO:0000269 for the same paper."", ""source_locator"": ""/comments/4/cofactors/0; /comments/4/note""}, {""reference_id"": ""PMID:30839292"", ""source_assertion"": ""The E. coli GldA structure contains active-site Zn2+ coordinated by His254, His271 and Asp171 and interacting with glycerol."", ""source_locator"": ""PMC6404857: Results and discussion 3.3, Overall structural details; Figure 3""}]"	"[{""id"": ""PMID:30839292"", ""source_sha256"": ""40df653530af56649dbfb283428b1e8d9fce15b945ce649c1db8ae7223e0e53e"", ""source_version"": ""Primary full text; retrieved 2026-10-10"", ""title"": ""Structure of glycerol dehydrogenase (GldA) from Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC6404857/?pdf=render""}, {""id"": ""UniProtKB:P0A9S5"", ""source_sha256"": ""faee284ee8a8c21d95764d891e90e9154d22c2fda5c891c59f0d890ffb577a49"", ""source_version"": ""2026_03; response release header and entry retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P0A9S5"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9S5.json""}]"	""
pathwaymech:MetaCyc_PWY-5453_mg3-edge-015_a35ae75e990e	RHEA:27988	BFO:0000050	MetaCyc:PWY-5453	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5453|MetaCyc:RXN0-4281		"[{""reference_id"": ""MetaCyc:PWY-5453"", ""source_assertion"": ""PWY-5453 lists RXN0-4281 in methylglyoxal degradation III and chooses its reductive direction in reaction-layout. The graph restricts the multispecies definition to the supported E. coli branch."", ""source_locator"": ""Pathway[@frameid=\""PWY-5453\""]/reaction-list/Reaction[@frameid=\""RXN0-4281\""]; reaction-layout; species""}, {""reference_id"": ""MetaCyc:RXN0-4281"", ""source_assertion"": ""Native RXN0-4281 provides the exact chemical sides and Rhea master cross-reference for the selected directional reaction."", ""source_locator"": ""Reaction/left; right; reaction-direction; dblink[dblink-db=\""RHEA\""]""}]"	"[{""id"": ""MetaCyc:PWY-5453"", ""source_sha256"": ""b2797839b180a1ff3be49882b2cb658b7fd0e826a972d29339fec76605beea07"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc PWY-5453"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5453""}, {""id"": ""MetaCyc:RXN0-4281"", ""source_sha256"": ""748b17d09a5e855078b1df9ae68568e2cefcee8e5b363b8341d78e590265c835"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc RXN0-4281"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-4281""}]"	""
pathwaymech:MetaCyc_PWY-5453_mg3-edge-016_8376ee8867fd	RHEA:28668	BFO:0000050	MetaCyc:PWY-5453	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5453|MetaCyc:RXN-8632		"[{""reference_id"": ""MetaCyc:PWY-5453"", ""source_assertion"": ""PWY-5453 lists RXN-8632 in methylglyoxal degradation III and chooses its reductive direction in reaction-layout. The graph restricts the multispecies definition to the supported E. coli branch."", ""source_locator"": ""Pathway[@frameid=\""PWY-5453\""]/reaction-list/Reaction[@frameid=\""RXN-8632\""]; reaction-layout; species""}, {""reference_id"": ""MetaCyc:RXN-8632"", ""source_assertion"": ""Native RXN-8632 provides the exact chemical sides and Rhea master cross-reference for the selected directional reaction."", ""source_locator"": ""Reaction/left; right; reaction-direction; dblink[dblink-db=\""RHEA\""]""}]"	"[{""id"": ""MetaCyc:PWY-5453"", ""source_sha256"": ""b2797839b180a1ff3be49882b2cb658b7fd0e826a972d29339fec76605beea07"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc PWY-5453"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5453""}, {""id"": ""MetaCyc:RXN-8632"", ""source_sha256"": ""c7366709561952a9ed759276b844325c2b0c5f4a54a8e30928123c671bcd11d6"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc RXN-8632"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8632""}]"	""
pathwaymech:MetaCyc_PWY-5453_mg3-edge-017_4fd2aad60315	RHEA:27988	RO:0002413	RHEA:28668	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5453|PMID:16077126	This is the annotated acetol-connected two-enzyme route. The 2005 diol observation is from engineered MG-accumulating CK281 derivatives or crude extracts, not a purified two-enzyme reconstitution or proof of unrestricted MG1655 flux.	"[{""reference_id"": ""MetaCyc:PWY-5453"", ""source_assertion"": ""PWY-5453 orders RXN0-4281 before RXN-8632, with acetol as the shared intermediate and both reactions selected in the reductive direction."", ""source_locator"": ""Pathway[@frameid=\""PWY-5453\""]/reaction-ordering[Reaction[@frameid=\""RXN-8632\""]]/predecessor-reactions; reaction-layout""}, {""reference_id"": ""PMID:16077126"", ""source_assertion"": ""The MG-accumulating strain and crude extracts produced acetol followed by small amounts of 1,2-propanediol; purified AKRs produced acetol but no detectable diol."", ""source_locator"": ""PMC1196063: Results, Detection of acetol from methylglyoxal-producing E. coli cells; Figure 2; MG-reducing activity in crude extracts; Figure 3B""}]"	"[{""id"": ""MetaCyc:PWY-5453"", ""source_sha256"": ""b2797839b180a1ff3be49882b2cb658b7fd0e826a972d29339fec76605beea07"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc PWY-5453"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5453""}, {""id"": ""PMID:16077126"", ""source_sha256"": ""7edca4dd5ce4a7ab4903200f3bacbdbc3d35a276cc7a241e7cecd4d3992cd574"", ""source_version"": ""Primary full text; retrieved 2026-10-10"", ""title"": ""Conversion of methylglyoxal to acetol by Escherichia coli aldo-keto reductases."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1196063/?pdf=render""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-001_6c91dda2b6e0	CHEBI:68684	pathwaymech:consumes	RHEA:34680	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34680		"[{""reference_id"": ""RHEA:34680"", ""source_assertion"": ""Rhea places CHEBI:68684 on the substrates side of directed RHEA:34680, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34680\""]/rh:substrates; http://rdf.rhea-db.org/34679_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_34679_compound_7585/rh:compound -> http://rdf.rhea-db.org/Compound_7585/rh:chebi""}]"	"[{""id"": ""RHEA:34680"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34680 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-002_9419b5bdd954	CHEBI:30616	pathwaymech:consumes	RHEA:34680	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34680		"[{""reference_id"": ""RHEA:34680"", ""source_assertion"": ""Rhea places CHEBI:30616 on the substrates side of directed RHEA:34680, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34680\""]/rh:substrates; http://rdf.rhea-db.org/34679_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_34679_compound_6372/rh:compound -> http://rdf.rhea-db.org/Compound_6372/rh:chebi""}]"	"[{""id"": ""RHEA:34680"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34680 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-003_db9c8e5361d0	RHEA:34680	pathwaymech:produces	CHEBI:68823	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34680		"[{""reference_id"": ""RHEA:34680"", ""source_assertion"": ""Rhea places CHEBI:68823 on the products side of directed RHEA:34680, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34680\""]/rh:products; http://rdf.rhea-db.org/34679_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_34679_compound_9342/rh:compound -> http://rdf.rhea-db.org/Compound_9342/rh:chebi""}]"	"[{""id"": ""RHEA:34680"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34680 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-004_6fcbc7821db3	RHEA:34680	pathwaymech:produces	CHEBI:16708	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34680		"[{""reference_id"": ""RHEA:34680"", ""source_assertion"": ""Rhea places CHEBI:16708 on the products side of directed RHEA:34680, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34680\""]/rh:products; http://rdf.rhea-db.org/34679_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_34679_compound_4174/rh:compound -> http://rdf.rhea-db.org/Compound_4174/rh:chebi""}]"	"[{""id"": ""RHEA:34680"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34680 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-005_b34a82d5e314	CHEBI:68823	pathwaymech:consumes	RHEA:34684	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34684		"[{""reference_id"": ""RHEA:34684"", ""source_assertion"": ""Rhea places CHEBI:68823 on the substrates side of directed RHEA:34684, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34684\""]/rh:substrates; http://rdf.rhea-db.org/34683_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_34683_compound_9342/rh:compound -> http://rdf.rhea-db.org/Compound_9342/rh:chebi""}]"	"[{""id"": ""RHEA:34684"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34684 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-006_01375be594df	CHEBI:15377	pathwaymech:consumes	RHEA:34684	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34684		"[{""reference_id"": ""RHEA:34684"", ""source_assertion"": ""Rhea places CHEBI:15377 on the substrates side of directed RHEA:34684, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34684\""]/rh:substrates; http://rdf.rhea-db.org/34683_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_34683_compound_1283/rh:compound -> http://rdf.rhea-db.org/Compound_1283/rh:chebi""}]"	"[{""id"": ""RHEA:34684"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34684 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-007_82e055eb0476	RHEA:34684	pathwaymech:produces	CHEBI:68686	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34684		"[{""reference_id"": ""RHEA:34684"", ""source_assertion"": ""Rhea places CHEBI:68686 on the products side of directed RHEA:34684, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34684\""]/rh:products; http://rdf.rhea-db.org/34683_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_34683_compound_7596/rh:compound -> http://rdf.rhea-db.org/Compound_7596/rh:chebi""}]"	"[{""id"": ""RHEA:34684"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34684 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-008_fb3fab5a0867	RHEA:34684	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34684		"[{""reference_id"": ""RHEA:34684"", ""source_assertion"": ""Rhea places CHEBI:33019 on the products side of directed RHEA:34684, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34684\""]/rh:products; http://rdf.rhea-db.org/34683_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_34683_compound_2106/rh:compound -> http://rdf.rhea-db.org/Compound_2106/rh:chebi""}]"	"[{""id"": ""RHEA:34684"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34684 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-009_5dd995655b26	RHEA:34684	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34684		"[{""reference_id"": ""RHEA:34684"", ""source_assertion"": ""Rhea places CHEBI:15378 on the products side of directed RHEA:34684, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34684\""]/rh:products; http://rdf.rhea-db.org/34683_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_34683_compound_3249/rh:compound -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:34684"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34684 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-010_9c87ab7a3612	CHEBI:68686	pathwaymech:consumes	RHEA:34708	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34708		"[{""reference_id"": ""RHEA:34708"", ""source_assertion"": ""Rhea places CHEBI:68686 on the substrates side of directed RHEA:34708, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34708\""]/rh:substrates; http://rdf.rhea-db.org/34707_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_34707_compound_7596/rh:compound -> http://rdf.rhea-db.org/Compound_7596/rh:chebi""}]"	"[{""id"": ""RHEA:34708"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34708 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-011_cea431b5fe5a	CHEBI:17499	pathwaymech:consumes	RHEA:34708	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34708	The Rhea AH2/A pair is generic. The reconstitution used dithionite; no physiological donor or carrier identity is asserted.	"[{""reference_id"": ""RHEA:34708"", ""source_assertion"": ""Rhea places CHEBI:17499 on the substrates side of directed RHEA:34708, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34708\""]/rh:substrates; http://rdf.rhea-db.org/34707_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_34707_compound_1304/rh:compound -> http://rdf.rhea-db.org/Compound_1304/rh:chebi""}]"	"[{""id"": ""RHEA:34708"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34708 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-012_a85c717f0846	CHEBI:59789	pathwaymech:consumes	RHEA:34708	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34708	Coefficient 1 belongs to the Rhea activation-associated reference equation. It does not establish a fixed SAM-to-methylphosphonate turnover ratio in the functioning complex.	"[{""reference_id"": ""RHEA:34708"", ""source_assertion"": ""Rhea places CHEBI:59789 on the substrates side of directed RHEA:34708, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34708\""]/rh:substrates; http://rdf.rhea-db.org/34707_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_34707_compound_6127/rh:compound -> http://rdf.rhea-db.org/Compound_6127/rh:chebi""}]"	"[{""id"": ""RHEA:34708"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34708 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-013_9dcf0363323f	RHEA:34708	pathwaymech:produces	CHEBI:68687	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34708		"[{""reference_id"": ""RHEA:34708"", ""source_assertion"": ""Rhea places CHEBI:68687 on the products side of directed RHEA:34708, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34708\""]/rh:products; http://rdf.rhea-db.org/34707_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_34707_compound_7601/rh:compound -> http://rdf.rhea-db.org/Compound_7601/rh:chebi""}]"	"[{""id"": ""RHEA:34708"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34708 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-014_6a4eade50ba0	RHEA:34708	pathwaymech:produces	CHEBI:16183	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34708		"[{""reference_id"": ""RHEA:34708"", ""source_assertion"": ""Rhea places CHEBI:16183 on the products side of directed RHEA:34708, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34708\""]/rh:products; http://rdf.rhea-db.org/34707_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_34707_compound_3576/rh:compound -> http://rdf.rhea-db.org/Compound_3576/rh:chebi""}]"	"[{""id"": ""RHEA:34708"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34708 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-015_07adff79e675	RHEA:34708	pathwaymech:produces	CHEBI:17319	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34708	Coefficient 1 belongs to the Rhea activation-associated reference equation. It does not establish a fixed SAM-to-methylphosphonate turnover ratio in the functioning complex.	"[{""reference_id"": ""RHEA:34708"", ""source_assertion"": ""Rhea places CHEBI:17319 on the products side of directed RHEA:34708, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34708\""]/rh:products; http://rdf.rhea-db.org/34707_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_34707_compound_2028/rh:compound -> http://rdf.rhea-db.org/Compound_2028/rh:chebi""}]"	"[{""id"": ""RHEA:34708"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34708 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-016_5d21cb59ae07	RHEA:34708	pathwaymech:produces	CHEBI:57844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34708	Coefficient 1 belongs to the Rhea activation-associated reference equation. It does not establish a fixed SAM-to-methylphosphonate turnover ratio in the functioning complex.	"[{""reference_id"": ""RHEA:34708"", ""source_assertion"": ""Rhea places CHEBI:57844 on the products side of directed RHEA:34708, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34708\""]/rh:products; http://rdf.rhea-db.org/34707_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_34707_compound_2530/rh:compound -> http://rdf.rhea-db.org/Compound_2530/rh:chebi""}]"	"[{""id"": ""RHEA:34708"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34708 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-017_00065f0b0751	RHEA:34708	pathwaymech:produces	CHEBI:13193	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34708	The Rhea AH2/A pair is generic. The reconstitution used dithionite; no physiological donor or carrier identity is asserted.	"[{""reference_id"": ""RHEA:34708"", ""source_assertion"": ""Rhea places CHEBI:13193 on the products side of directed RHEA:34708, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34708\""]/rh:products; http://rdf.rhea-db.org/34707_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_34707_compound_3512/rh:compound -> http://rdf.rhea-db.org/Compound_3512/rh:chebi""}]"	"[{""id"": ""RHEA:34708"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34708 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-018_bcd25e5715ee	RHEA:34708	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34708		"[{""reference_id"": ""RHEA:34708"", ""source_assertion"": ""Rhea places CHEBI:15378 on the products side of directed RHEA:34708, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34708\""]/rh:products; http://rdf.rhea-db.org/34707_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_34707_compound_3249/rh:compound -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:34708"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34708 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-019_8f9a361ec502	CHEBI:68687	pathwaymech:consumes	RHEA:34796	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34796		"[{""reference_id"": ""RHEA:34796"", ""source_assertion"": ""Rhea places CHEBI:68687 on the substrates side of directed RHEA:34796, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34796\""]/rh:substrates; http://rdf.rhea-db.org/34795_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_34795_compound_7601/rh:compound -> http://rdf.rhea-db.org/Compound_7601/rh:chebi""}]"	"[{""id"": ""RHEA:34796"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34796 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-020_22aa0f8ae70f	CHEBI:15377	pathwaymech:consumes	RHEA:34796	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34796		"[{""reference_id"": ""RHEA:34796"", ""source_assertion"": ""Rhea places CHEBI:15377 on the substrates side of directed RHEA:34796, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34796\""]/rh:substrates; http://rdf.rhea-db.org/34795_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_34795_compound_1283/rh:compound -> http://rdf.rhea-db.org/Compound_1283/rh:chebi""}]"	"[{""id"": ""RHEA:34796"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34796 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-021_183db5d7868e	RHEA:34796	pathwaymech:produces	CHEBI:68688	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34796		"[{""reference_id"": ""RHEA:34796"", ""source_assertion"": ""Rhea places CHEBI:68688 on the products side of directed RHEA:34796, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34796\""]/rh:products; http://rdf.rhea-db.org/34795_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_34795_compound_7560/rh:compound -> http://rdf.rhea-db.org/Compound_7560/rh:chebi""}]"	"[{""id"": ""RHEA:34796"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34796 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-022_b743e35f61cc	RHEA:34796	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34796		"[{""reference_id"": ""RHEA:34796"", ""source_assertion"": ""Rhea places CHEBI:15378 on the products side of directed RHEA:34796, with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34796\""]/rh:products; http://rdf.rhea-db.org/34795_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_34795_compound_3249/rh:compound -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:34796"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34796 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-023_ffe0e2363483	PathBank:SMP0002077/ProteinComplex/4049	BFO:0000051	UniProtKB:P16686	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002077	This is PathBank’s PhnG/H/I/L assembly for the first reconstructed reaction. No subunit copy number or equivalence to the later full C-P lyase complex is asserted.	"[{""reference_id"": ""PathBank:SMP0002077"", ""source_assertion"": ""Native ProteinComplex/4049 lists Protein/10370 as a component; its ProteinReference resolves through a UniProt xref to P16686."", ""source_locator"": ""bp:Complex[@rdf:ID=\""ProteinComplex/4049\""]/bp:component[@rdf:resource=\""#Protein/10370\""]; ProteinReference/10370/bp:xref""}]"	"[{""id"": ""PathBank:SMP0002077"", ""source_sha256"": ""66e835939e82188e3c976f0eda7ab68fa3d6fd8064bb18b1c4df439abec4cc62"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002065.owl"", ""title"": ""PathBank Methylphosphonate Degradation I, native BioPAX member PW002065.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-024_994406dcf43b	PathBank:SMP0002077/ProteinComplex/4049	BFO:0000051	UniProtKB:P16679	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002077	This is PathBank’s PhnG/H/I/L assembly for the first reconstructed reaction. No subunit copy number or equivalence to the later full C-P lyase complex is asserted.	"[{""reference_id"": ""PathBank:SMP0002077"", ""source_assertion"": ""Native ProteinComplex/4049 lists Protein/10369 as a component; its ProteinReference resolves through a UniProt xref to P16679."", ""source_locator"": ""bp:Complex[@rdf:ID=\""ProteinComplex/4049\""]/bp:component[@rdf:resource=\""#Protein/10369\""]; ProteinReference/10369/bp:xref""}]"	"[{""id"": ""PathBank:SMP0002077"", ""source_sha256"": ""66e835939e82188e3c976f0eda7ab68fa3d6fd8064bb18b1c4df439abec4cc62"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002065.owl"", ""title"": ""PathBank Methylphosphonate Degradation I, native BioPAX member PW002065.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-025_a831635fe8d5	PathBank:SMP0002077/ProteinComplex/4049	BFO:0000051	UniProtKB:P16685	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002077	This is PathBank’s PhnG/H/I/L assembly for the first reconstructed reaction. No subunit copy number or equivalence to the later full C-P lyase complex is asserted.	"[{""reference_id"": ""PathBank:SMP0002077"", ""source_assertion"": ""Native ProteinComplex/4049 lists Protein/10371 as a component; its ProteinReference resolves through a UniProt xref to P16685."", ""source_locator"": ""bp:Complex[@rdf:ID=\""ProteinComplex/4049\""]/bp:component[@rdf:resource=\""#Protein/10371\""]; ProteinReference/10371/bp:xref""}]"	"[{""id"": ""PathBank:SMP0002077"", ""source_sha256"": ""66e835939e82188e3c976f0eda7ab68fa3d6fd8064bb18b1c4df439abec4cc62"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002065.owl"", ""title"": ""PathBank Methylphosphonate Degradation I, native BioPAX member PW002065.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-026_1cca80e6b15b	PathBank:SMP0002077/ProteinComplex/4049	BFO:0000051	UniProtKB:P16687	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002077	This is PathBank’s PhnG/H/I/L assembly for the first reconstructed reaction. No subunit copy number or equivalence to the later full C-P lyase complex is asserted.	"[{""reference_id"": ""PathBank:SMP0002077"", ""source_assertion"": ""Native ProteinComplex/4049 lists Protein/10372 as a component; its ProteinReference resolves through a UniProt xref to P16687."", ""source_locator"": ""bp:Complex[@rdf:ID=\""ProteinComplex/4049\""]/bp:component[@rdf:resource=\""#Protein/10372\""]; ProteinReference/10372/bp:xref""}]"	"[{""id"": ""PathBank:SMP0002077"", ""source_sha256"": ""66e835939e82188e3c976f0eda7ab68fa3d6fd8064bb18b1c4df439abec4cc62"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002065.owl"", ""title"": ""PathBank Methylphosphonate Degradation I, native BioPAX member PW002065.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-027_e0dca51e057e	PathBank:SMP0002077/ProteinComplex/4049	pathwaymech:catalyzes	RHEA:34680	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:22089136|PathBank:SMP0002077|RHEA:34680|UniProtKB:P16687	The four proteins support the complete first reaction. PhnI alone has a separate nucleosidase activity, which is not this pathway reaction; no individual accessory subunit is asserted to catalyze the overall transformation alone. The reconstructed reaction used MgATP. This assay condition does not establish a specific magnesium-binding site or obligatory cofactor relation for the assembly, and no magnesium independence is asserted.	"[{""reference_id"": ""PathBank:SMP0002077"", ""source_assertion"": ""Catalysis ReactionCatalysis/6000 identifies ProteinComplex/4049 as controller of Reactions/6035, the ATP+methylphosphonate reaction with EC 2.7.8.37."", ""source_locator"": ""bp:Catalysis[@rdf:ID=\""ReactionCatalysis/6000\""]/bp:controller,bp:controlled; bp:BiochemicalReaction[@rdf:ID=\""Reactions/6035\""]/bp:eCNumber""}, {""reference_id"": ""UniProtKB:P16687"", ""source_assertion"": ""PhnI FUNCTION requires PhnG, PhnH and PhnL for ribose-triphosphate transfer; CATALYTIC ACTIVITY assigns that transformation to RHEA:34679 with ECO:0000269 (PMID:22089136)."", ""source_locator"": ""comments[commentType=\""FUNCTION\""]; comments[commentType=\""CATALYTIC ACTIVITY\""].reaction[reactionCrossReferences.id=\""RHEA:34679\""]""}, {""reference_id"": ""RHEA:34680"", ""source_assertion"": ""Rhea master 34679 specifies 34680 as its left-to-right directional reaction."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34679\""]/rh:directionalReaction; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34680\""]/rh:substrates,rh:products""}, {""quote"": ""PhnI, in the presence of PhnG, PhnH, and PhnL"", ""reference_id"": ""PMID:22089136"", ""source_locator"": ""PMC3245791 BioC passage offset 4703""}, {""quote"": ""methylphosphonate reacts with MgATP"", ""reference_id"": ""PMID:22089136"", ""source_locator"": ""Abstract""}]"	"[{""id"": ""PMID:22089136"", ""title"": ""Intermediates in the transformation of phosphonates to phosphate by bacteria."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/22089136/""}, {""id"": ""PathBank:SMP0002077"", ""source_sha256"": ""66e835939e82188e3c976f0eda7ab68fa3d6fd8064bb18b1c4df439abec4cc62"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002065.owl"", ""title"": ""PathBank Methylphosphonate Degradation I, native BioPAX member PW002065.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:34680"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34680 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P16687"", ""source_sha256"": ""cf6eb26d4a4206420af2ad14d50aa214b66957dc4721f02374abb04b580e3826"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P16687, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P16687.json""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-028_8efae131bd57	UniProtKB:P16689	pathwaymech:catalyzes	RHEA:34684	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34684|UniProtKB:P16689	The primary PhnM assay contained MgCl2 and ZnCl2. Their presence in that assay is retained as a condition, without claiming both are independently established obligatory cofactors.	"[{""reference_id"": ""UniProtKB:P16689"", ""source_assertion"": ""UniProt CATALYTIC ACTIVITY assigns this protein to RHEA:34683 with ECO:0000269; the selected catabolic direction is RHEA:34684."", ""source_locator"": ""comments[commentType=\""CATALYTIC ACTIVITY\""].reaction[reactionCrossReferences.id=\""RHEA:34683\""]""}, {""reference_id"": ""RHEA:34684"", ""source_assertion"": ""Rhea master 34683 identifies 34684 as its left-to-right directional reaction."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34683\""]/rh:directionalReaction; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34684\""]/rh:substrates,rh:products""}]"	"[{""id"": ""RHEA:34684"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34684 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P16689"", ""source_sha256"": ""ed17b332cca349cf95b3cad5164777c3760aba7d9653e8fa35262cc36b4b1622"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P16689, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P16689.json""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-029_dee9dc80ff27	UniProtKB:P16688	pathwaymech:catalyzes	RHEA:34708	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34708|UniProtKB:P16688	The source reconstitution used anaerobic conditions, an iron-sulfur cluster, SAM, dithionite and cleavage of the GST tag. Later mechanistic work distinguishes radical activation from repeated substrate turnover.	"[{""reference_id"": ""UniProtKB:P16688"", ""source_assertion"": ""UniProt CATALYTIC ACTIVITY assigns this protein to RHEA:34707 with ECO:0000269; the selected catabolic direction is RHEA:34708."", ""source_locator"": ""comments[commentType=\""CATALYTIC ACTIVITY\""].reaction[reactionCrossReferences.id=\""RHEA:34707\""]""}, {""reference_id"": ""RHEA:34708"", ""source_assertion"": ""Rhea master 34707 identifies 34708 as its left-to-right directional reaction."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34707\""]/rh:directionalReaction; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34708\""]/rh:substrates,rh:products""}]"	"[{""id"": ""RHEA:34708"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34708 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P16688"", ""source_sha256"": ""23a26095adfc24be8778e4dd102a8d8ddbc277e5b1195d8607fcc64706b4ff3a"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P16688, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P16688.json""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-030_fb85dcee5e93	UniProtKB:P16692	pathwaymech:catalyzes	RHEA:34796	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21341651|RHEA:34796|UniProtKB:P16692	The physiological cyclic ribose-phosphate substrate was established in PMID:21341651; the earlier PMID:19366688 characterized structure and metal-dependent phosphodiesterase activity with other substrates.	"[{""reference_id"": ""UniProtKB:P16692"", ""source_assertion"": ""UniProt CATALYTIC ACTIVITY assigns this protein to RHEA:34795 with ECO:0000269; the selected catabolic direction is RHEA:34796."", ""source_locator"": ""comments[commentType=\""CATALYTIC ACTIVITY\""].reaction[reactionCrossReferences.id=\""RHEA:34795\""]""}, {""reference_id"": ""RHEA:34796"", ""source_assertion"": ""Rhea master 34795 identifies 34796 as its left-to-right directional reaction."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34795\""]/rh:directionalReaction; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34796\""]/rh:substrates,rh:products""}, {""quote"": ""regiospecifically converted by PhnP to α-D-ribosyl 1,5-bisphosphate"", ""reference_id"": ""PMID:21341651"", ""source_locator"": ""Abstract, synthesized 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate experiment""}]"	"[{""id"": ""PMID:21341651"", ""title"": ""Physiological role of phnP-specified phosphoribosyl cyclic phosphodiesterase in catabolism of organophosphonic acids by the carbon-phosphorus lyase pathway."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/21341651/""}, {""id"": ""RHEA:34796"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34796 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P16692"", ""source_sha256"": ""901bc7968a2cff2e7678da8872439eeb21942fa514d1607d317bca5557bb093d"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P16692, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P16692.json""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-032_a476da5e0e32	UniProtKB:P16688	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:22089136|UniProtKB:P16688	CHEBI:49883 identifies the cluster class rather than its oxidation state. The catalytically active reduced state and anaerobic reconstitution conditions are explicit here; Zn observed at this site in aerobic structures is not substituted for the active Fe-S cluster.	"[{""reference_id"": ""UniProtKB:P16688"", ""source_assertion"": ""UniProt lists one [4Fe-4S] cluster per PhnJ subunit with ECO:0000269 from PMID:22089136."", ""source_locator"": ""comments[commentType=\""COFACTOR\""].cofactors[cofactorCrossReference.id=\""CHEBI:49883\""]; note.texts""}, {""quote"": ""requires a reduced [4Fe-4S]-cluster and SAM"", ""reference_id"": ""PMID:22089136"", ""source_locator"": ""PMC3245791 BioC passage offset 9520""}]"	"[{""id"": ""PMID:22089136"", ""title"": ""Intermediates in the transformation of phosphonates to phosphate by bacteria."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/22089136/""}, {""id"": ""UniProtKB:P16688"", ""source_sha256"": ""23a26095adfc24be8778e4dd102a8d8ddbc277e5b1195d8607fcc64706b4ff3a"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P16688, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P16688.json""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-033_662cae0d525e	UniProtKB:P16692	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19366688|UniProtKB:P16692	The source metal-preference experiment used bis(p-nitrophenyl)phosphate. Ni2+ also supported activity; this edge does not assert exclusive Mn2+ usage or transfer that substrate-specific comparison to every physiological condition.	"[{""reference_id"": ""UniProtKB:P16692"", ""source_assertion"": ""UniProt reports binding of two manganese ions per PhnP subunit with ECO:0000269 from PMID:19366688."", ""source_locator"": ""comments[commentType=\""COFACTOR\""].cofactors[cofactorCrossReference.id=\""CHEBI:29035\""]; note.texts""}, {""quote"": ""distinct preference for Mn(2+) and Ni(2+) for catalysis"", ""reference_id"": ""PMID:19366688"", ""source_locator"": ""Abstract, metal dependence with bis(p-nitrophenyl)phosphate""}]"	"[{""id"": ""PMID:19366688"", ""title"": ""Structure of PhnP, a phosphodiesterase of the carbon-phosphorus lyase pathway for phosphonate degradation."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/19366688/""}, {""id"": ""UniProtKB:P16692"", ""source_sha256"": ""901bc7968a2cff2e7678da8872439eeb21942fa514d1607d317bca5557bb093d"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P16692, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P16692.json""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-034_ff7e64163314	UniProtKB:P16692	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19366688|UniProtKB:P16692	The zinc site is remote from the catalytic metal center and was assigned a structural role. Zinc gave poor activity in the catalytic metal-substitution assay; this is not a claim that Zn2+ substitutes equivalently for catalytic manganese.	"[{""reference_id"": ""UniProtKB:P16692"", ""source_assertion"": ""UniProt reports binding of one zinc ion per PhnP subunit with ECO:0000269 from PMID:19366688."", ""source_locator"": ""comments[commentType=\""COFACTOR\""].cofactors[cofactorCrossReference.id=\""CHEBI:29105\""]; note.texts""}, {""quote"": ""This second metal ion site appears to stabilize a structural motif."", ""reference_id"": ""PMID:19366688"", ""source_locator"": ""Abstract, remote Zn2+ binding site""}]"	"[{""id"": ""PMID:19366688"", ""title"": ""Structure of PhnP, a phosphodiesterase of the carbon-phosphorus lyase pathway for phosphonate degradation."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/19366688/""}, {""id"": ""UniProtKB:P16692"", ""source_sha256"": ""901bc7968a2cff2e7678da8872439eeb21942fa514d1607d317bca5557bb093d"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P16692, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P16692.json""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-035_ceb174a3ed7d	RHEA:34680	BFO:0000050	PathBank:SMP0002077	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002077|RHEA:34680|UniProtKB:P16687	Manual reaction correspondence combines matching native transformation/EC, protein catalytic annotation, and exact Rhea sides. PathBank supplies no native Rhea cross-reference.	"[{""reference_id"": ""PathBank:SMP0002077"", ""source_assertion"": ""The native SMP0002077 Pathway explicitly includes Reactions/6035; that reaction carries EC 2.7.8.37."", ""source_locator"": ""bp:Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002077\""]/bp:pathwayComponent[@rdf:resource=\""#Reactions/6035\""]; bp:BiochemicalReaction[@rdf:ID=\""Reactions/6035\""]/bp:eCNumber""}, {""reference_id"": ""UniProtKB:P16687"", ""source_assertion"": ""The corresponding E. coli protein annotation assigns EC 2.7.8.37 and RHEA:34679 to this transformation. Native PathBank membership and this independent reaction grounding are separate assertions."", ""source_locator"": ""comments[commentType=\""CATALYTIC ACTIVITY\""].reaction[ecNumber=\""2.7.8.37\""]; reactionCrossReferences""}, {""reference_id"": ""RHEA:34680"", ""source_assertion"": ""Rhea defines directed RHEA:34680 from master RHEA:34679; its charge-balanced participants are retained instead of the older PathBank charge forms."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34679\""]/rh:directionalReaction; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34680\""]/rh:substrates,rh:products""}]"	"[{""id"": ""PathBank:SMP0002077"", ""source_sha256"": ""66e835939e82188e3c976f0eda7ab68fa3d6fd8064bb18b1c4df439abec4cc62"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002065.owl"", ""title"": ""PathBank Methylphosphonate Degradation I, native BioPAX member PW002065.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:34680"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34680 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P16687"", ""source_sha256"": ""cf6eb26d4a4206420af2ad14d50aa214b66957dc4721f02374abb04b580e3826"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P16687, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P16687.json""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-036_2a4abe9f84bc	RHEA:34684	BFO:0000050	PathBank:SMP0002077	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002077|RHEA:34684|UniProtKB:P16689	Manual reaction correspondence combines matching native transformation/EC, protein catalytic annotation, and exact Rhea sides. PathBank supplies no native Rhea cross-reference.	"[{""reference_id"": ""PathBank:SMP0002077"", ""source_assertion"": ""The native SMP0002077 Pathway explicitly includes Reactions/6036; that reaction carries EC 3.6.1.63."", ""source_locator"": ""bp:Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002077\""]/bp:pathwayComponent[@rdf:resource=\""#Reactions/6036\""]; bp:BiochemicalReaction[@rdf:ID=\""Reactions/6036\""]/bp:eCNumber""}, {""reference_id"": ""UniProtKB:P16689"", ""source_assertion"": ""The corresponding E. coli protein annotation assigns EC 3.6.1.63 and RHEA:34683 to this transformation. Native PathBank membership and this independent reaction grounding are separate assertions."", ""source_locator"": ""comments[commentType=\""CATALYTIC ACTIVITY\""].reaction[ecNumber=\""3.6.1.63\""]; reactionCrossReferences""}, {""reference_id"": ""RHEA:34684"", ""source_assertion"": ""Rhea defines directed RHEA:34684 from master RHEA:34683; its charge-balanced participants are retained instead of the older PathBank charge forms."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34683\""]/rh:directionalReaction; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34684\""]/rh:substrates,rh:products""}]"	"[{""id"": ""PathBank:SMP0002077"", ""source_sha256"": ""66e835939e82188e3c976f0eda7ab68fa3d6fd8064bb18b1c4df439abec4cc62"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002065.owl"", ""title"": ""PathBank Methylphosphonate Degradation I, native BioPAX member PW002065.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:34684"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34684 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P16689"", ""source_sha256"": ""ed17b332cca349cf95b3cad5164777c3760aba7d9653e8fa35262cc36b4b1622"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P16689, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P16689.json""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-037_f28b804d6037	RHEA:34708	BFO:0000050	PathBank:SMP0002077	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002077|RHEA:34708|UniProtKB:P16688	Manual reaction correspondence combines matching native transformation/EC, protein catalytic annotation, and exact Rhea sides. PathBank supplies no native Rhea cross-reference. PhnJ’s Rhea equation additionally includes the radical-activation reagents and products absent from the native minimal equation.	"[{""reference_id"": ""PathBank:SMP0002077"", ""source_assertion"": ""The native SMP0002077 Pathway explicitly includes Reactions/6037; that reaction carries EC 4.7.1.1."", ""source_locator"": ""bp:Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002077\""]/bp:pathwayComponent[@rdf:resource=\""#Reactions/6037\""]; bp:BiochemicalReaction[@rdf:ID=\""Reactions/6037\""]/bp:eCNumber""}, {""reference_id"": ""UniProtKB:P16688"", ""source_assertion"": ""The corresponding E. coli protein annotation assigns EC 4.7.1.1 and RHEA:34707 to this transformation. Native PathBank membership and this independent reaction grounding are separate assertions."", ""source_locator"": ""comments[commentType=\""CATALYTIC ACTIVITY\""].reaction[ecNumber=\""4.7.1.1\""]; reactionCrossReferences""}, {""reference_id"": ""RHEA:34708"", ""source_assertion"": ""Rhea defines directed RHEA:34708 from master RHEA:34707; its charge-balanced participants are retained instead of the older PathBank charge forms."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34707\""]/rh:directionalReaction; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34708\""]/rh:substrates,rh:products""}]"	"[{""id"": ""PathBank:SMP0002077"", ""source_sha256"": ""66e835939e82188e3c976f0eda7ab68fa3d6fd8064bb18b1c4df439abec4cc62"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002065.owl"", ""title"": ""PathBank Methylphosphonate Degradation I, native BioPAX member PW002065.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:34708"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34708 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P16688"", ""source_sha256"": ""23a26095adfc24be8778e4dd102a8d8ddbc277e5b1195d8607fcc64706b4ff3a"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P16688, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P16688.json""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-038_a6c755c730af	RHEA:34796	BFO:0000050	PathBank:SMP0002077	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002077|RHEA:34796|UniProtKB:P16692	Manual reaction correspondence combines matching native transformation/EC, protein catalytic annotation, and exact Rhea sides. PathBank supplies no native Rhea cross-reference.	"[{""reference_id"": ""PathBank:SMP0002077"", ""source_assertion"": ""The native SMP0002077 Pathway explicitly includes Reactions/6038; that reaction carries EC 3.1.4.55."", ""source_locator"": ""bp:Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002077\""]/bp:pathwayComponent[@rdf:resource=\""#Reactions/6038\""]; bp:BiochemicalReaction[@rdf:ID=\""Reactions/6038\""]/bp:eCNumber""}, {""reference_id"": ""UniProtKB:P16692"", ""source_assertion"": ""The corresponding E. coli protein annotation assigns EC 3.1.4.55 and RHEA:34795 to this transformation. Native PathBank membership and this independent reaction grounding are separate assertions."", ""source_locator"": ""comments[commentType=\""CATALYTIC ACTIVITY\""].reaction[ecNumber=\""3.1.4.55\""]; reactionCrossReferences""}, {""reference_id"": ""RHEA:34796"", ""source_assertion"": ""Rhea defines directed RHEA:34796 from master RHEA:34795; its charge-balanced participants are retained instead of the older PathBank charge forms."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34795\""]/rh:directionalReaction; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34796\""]/rh:substrates,rh:products""}]"	"[{""id"": ""PathBank:SMP0002077"", ""source_sha256"": ""66e835939e82188e3c976f0eda7ab68fa3d6fd8064bb18b1c4df439abec4cc62"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002065.owl"", ""title"": ""PathBank Methylphosphonate Degradation I, native BioPAX member PW002065.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:34796"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34796 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P16692"", ""source_sha256"": ""901bc7968a2cff2e7678da8872439eeb21942fa514d1607d317bca5557bb093d"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P16692, Escherichia coli K-12"", ""url"": ""https://rest.uniprot.org/uniprotkb/P16692.json""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-039_45dd11d011df	RHEA:34680	RO:0002413	RHEA:34684	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34680|RHEA:34684	Material transfer through the identified ribose intermediate establishes the reaction sequence. Native pathwayOrder contains membership links, not nextStep ordering assertions.	"[{""reference_id"": ""RHEA:34680"", ""source_assertion"": ""The products of RHEA:34680 include CHEBI:68823."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34680\""]/rh:products; rh:contains1/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:34684"", ""source_assertion"": ""The substrates of RHEA:34684 include CHEBI:68823."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34684\""]/rh:substrates; rh:contains1/rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:34680"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34680 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:34684"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34684 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-040_200d7cc30529	RHEA:34684	RO:0002413	RHEA:34708	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34684|RHEA:34708	Material transfer through the identified ribose intermediate establishes the reaction sequence. Native pathwayOrder contains membership links, not nextStep ordering assertions.	"[{""reference_id"": ""RHEA:34684"", ""source_assertion"": ""The products of RHEA:34684 include CHEBI:68686."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34684\""]/rh:products; rh:contains1/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:34708"", ""source_assertion"": ""The substrates of RHEA:34708 include CHEBI:68686."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34708\""]/rh:substrates; rh:contains1/rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:34684"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34684 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:34708"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34708 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002077_methylphosphonate-edge-041_c0f258fe5ce6	RHEA:34708	RO:0002413	RHEA:34796	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34708|RHEA:34796	Material transfer through the identified ribose intermediate establishes the reaction sequence. Native pathwayOrder contains membership links, not nextStep ordering assertions.	"[{""reference_id"": ""RHEA:34708"", ""source_assertion"": ""The products of RHEA:34708 include CHEBI:68687."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34708\""]/rh:products; rh:contains1/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:34796"", ""source_assertion"": ""The substrates of RHEA:34796 include CHEBI:68687."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/34796\""]/rh:substrates; rh:contains1/rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:34708"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34708 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:34796"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 34796 directed methylphosphonate pathway reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-001_8084bbdbed66	CHEBI:49016	pathwaymech:consumes	RHEA:43053	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43053		"[{""reference_id"": ""RHEA:43053"", ""source_assertion"": ""Rhea places CHEBI:49016 on the substrates side of directed RHEA:43053, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43053/rh:substrates; http://rdf.rhea-db.org/43052_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_43052_compound_6054/rh:compound -> http://rdf.rhea-db.org/Compound_6054/rh:chebi""}]"	"[{""id"": ""RHEA:43053"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 43053 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-002_2870f25e2cae	CHEBI:30616	pathwaymech:consumes	RHEA:43053	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43053		"[{""reference_id"": ""RHEA:43053"", ""source_assertion"": ""Rhea places CHEBI:30616 on the substrates side of directed RHEA:43053, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43053/rh:substrates; http://rdf.rhea-db.org/43052_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_43052_compound_6372/rh:compound -> http://rdf.rhea-db.org/Compound_6372/rh:chebi""}]"	"[{""id"": ""RHEA:43053"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 43053 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-003_45559072a1a7	CHEBI:57287	pathwaymech:consumes	RHEA:43053	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43053		"[{""reference_id"": ""RHEA:43053"", ""source_assertion"": ""Rhea places CHEBI:57287 on the substrates side of directed RHEA:43053, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43053/rh:substrates; http://rdf.rhea-db.org/43052_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_43052_compound_1264/rh:compound -> http://rdf.rhea-db.org/Compound_1264/rh:chebi""}]"	"[{""id"": ""RHEA:43053"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 43053 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-004_5f7c2ff6f439	RHEA:43053	pathwaymech:produces	CHEBI:82815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43053		"[{""reference_id"": ""RHEA:43053"", ""source_assertion"": ""Rhea places CHEBI:82815 on the products side of directed RHEA:43053, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43053/rh:products; http://rdf.rhea-db.org/43052_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_43052_compound_10325/rh:compound -> http://rdf.rhea-db.org/Compound_10325/rh:chebi""}]"	"[{""id"": ""RHEA:43053"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 43053 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-005_043d37c1c5fb	RHEA:43053	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43053		"[{""reference_id"": ""RHEA:43053"", ""source_assertion"": ""Rhea places CHEBI:456215 on the products side of directed RHEA:43053, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43053/rh:products; http://rdf.rhea-db.org/43052_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_43052_compound_2590/rh:compound -> http://rdf.rhea-db.org/Compound_2590/rh:chebi""}]"	"[{""id"": ""RHEA:43053"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 43053 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-006_529f2ae06363	RHEA:43053	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43053		"[{""reference_id"": ""RHEA:43053"", ""source_assertion"": ""Rhea places CHEBI:33019 on the products side of directed RHEA:43053, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43053/rh:products; http://rdf.rhea-db.org/43052_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_43052_compound_2106/rh:compound -> http://rdf.rhea-db.org/Compound_2106/rh:chebi""}]"	"[{""id"": ""RHEA:43053"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 43053 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-007_85a4de368859	CHEBI:82815	pathwaymech:consumes	RHEA:52613	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:52613		"[{""reference_id"": ""RHEA:52613"", ""source_assertion"": ""Rhea places CHEBI:82815 on the substrates side of directed RHEA:52613, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/52613/rh:substrates; http://rdf.rhea-db.org/52612_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_52612_compound_10325/rh:compound -> http://rdf.rhea-db.org/Compound_10325/rh:chebi""}]"	"[{""id"": ""RHEA:52613"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 52613 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-008_811b21bbfcad	RHEA-COMP:10685	pathwaymech:consumes	RHEA:52613	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-12572|RHEA:52613|UniProtKB:Q5LLW7	This whole generic carrier state is the curated database acceptor-class convention, not a specific DSS-3 protein. Primary assays establish MMPA-CoA oxidation with artificial acceptors; the physiological flavoprotein partner remains unresolved. Carrier-bound FAD is not a substitute node for the carrier.	"[{""reference_id"": ""RHEA:52613"", ""source_assertion"": ""Rhea places RHEA-COMP:10685 on the substrates side of directed RHEA:52613, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/52613/rh:substrates; http://rdf.rhea-db.org/52612_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_52612_compound_10685/rh:compound -> http://rdf.rhea-db.org/Compound_10685/rh:id, rh:name, rdfs:subClassOf""}, {""reference_id"": ""MetaCyc:RXN-12572"", ""source_assertion"": ""The native reaction explicitly places the generic protein class ETF-Oxidized on its left side; it does not identify a strain-specific ETF protein."", ""source_locator"": ""Reaction[@frameid=\""RXN-12572\""]/left/Protein[@frameid=\""ETF-Oxidized\""]""}, {""reference_id"": ""UniProtKB:Q5LLW7"", ""source_assertion"": ""The reviewed catalytic-activity entry cross-references RHEA:52612 and both generic ETF components. Its attached 2011 citation does not experimentally identify the physiological carrier."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences; comments[1].reaction.evidences""}]"	"[{""id"": ""MetaCyc:RXN-12572"", ""source_sha256"": ""04a0a61426eab155a17af1b5a19e857e62027bab4a3725321686cc17ad859ef4"", ""source_version"": ""MetaCyc 22.5; original native XML"", ""title"": ""MetaCyc RXN-12572 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-12572""}, {""id"": ""RHEA:52613"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 52613 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:Q5LLW7"", ""source_sha256"": ""20c9da5a16f07742e977babfb463eb67c1b243b1b4ddc70b03e34375119092c5"", ""source_version"": ""2026_03 (2026-09-02)"", ""title"": ""UniProtKB Q5LLW7, Ruegeria pomeroyi DSS-3"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q5LLW7.json""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-009_8df3508362e7	CHEBI:15378	pathwaymech:consumes	RHEA:52613	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:52613		"[{""reference_id"": ""RHEA:52613"", ""source_assertion"": ""Rhea places CHEBI:15378 on the substrates side of directed RHEA:52613, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/52613/rh:substrates; http://rdf.rhea-db.org/52612_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_52612_compound_3249/rh:compound -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:52613"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 52613 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-010_4a6fc267b020	RHEA:52613	pathwaymech:produces	CHEBI:84994	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:52613		"[{""reference_id"": ""RHEA:52613"", ""source_assertion"": ""Rhea places CHEBI:84994 on the products side of directed RHEA:52613, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/52613/rh:products; http://rdf.rhea-db.org/52612_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_52612_compound_11096/rh:compound -> http://rdf.rhea-db.org/Compound_11096/rh:chebi""}]"	"[{""id"": ""RHEA:52613"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 52613 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-011_b62a0f0ba4bf	RHEA:52613	pathwaymech:produces	RHEA-COMP:10686	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-12572|RHEA:52613|UniProtKB:Q5LLW7	This whole generic carrier state is the curated database acceptor-class convention, not a specific DSS-3 protein. Primary assays establish MMPA-CoA oxidation with artificial acceptors; the physiological flavoprotein partner remains unresolved. Carrier-bound FAD is not a substitute node for the carrier.	"[{""reference_id"": ""RHEA:52613"", ""source_assertion"": ""Rhea places RHEA-COMP:10686 on the products side of directed RHEA:52613, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/52613/rh:products; http://rdf.rhea-db.org/52612_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_52612_compound_10686/rh:compound -> http://rdf.rhea-db.org/Compound_10686/rh:id, rh:name, rdfs:subClassOf""}, {""reference_id"": ""MetaCyc:RXN-12572"", ""source_assertion"": ""The native reaction explicitly places the generic protein class ETF-Reduced on its right side; it does not identify a strain-specific ETF protein."", ""source_locator"": ""Reaction[@frameid=\""RXN-12572\""]/right/Protein[@frameid=\""ETF-Reduced\""]""}, {""reference_id"": ""UniProtKB:Q5LLW7"", ""source_assertion"": ""The reviewed catalytic-activity entry cross-references RHEA:52612 and both generic ETF components. Its attached 2011 citation does not experimentally identify the physiological carrier."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences; comments[1].reaction.evidences""}]"	"[{""id"": ""MetaCyc:RXN-12572"", ""source_sha256"": ""04a0a61426eab155a17af1b5a19e857e62027bab4a3725321686cc17ad859ef4"", ""source_version"": ""MetaCyc 22.5; original native XML"", ""title"": ""MetaCyc RXN-12572 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-12572""}, {""id"": ""RHEA:52613"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 52613 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:Q5LLW7"", ""source_sha256"": ""20c9da5a16f07742e977babfb463eb67c1b243b1b4ddc70b03e34375119092c5"", ""source_version"": ""2026_03 (2026-09-02)"", ""title"": ""UniProtKB Q5LLW7, Ruegeria pomeroyi DSS-3"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q5LLW7.json""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-012_aeeaa75f9b44	CHEBI:84994	pathwaymech:consumes	RHEA:45145	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45145	This is a side of the single terminal net reaction. DmdD catalyzes hydration and hydrolysis; methanethiol elimination and subsequent decarboxylation are spontaneous or expected spontaneous steps within that net conversion.	"[{""reference_id"": ""RHEA:45145"", ""source_assertion"": ""Rhea places CHEBI:84994 on the substrates side of directed RHEA:45145, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/45145/rh:substrates; http://rdf.rhea-db.org/45144_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_45144_compound_11096/rh:compound -> http://rdf.rhea-db.org/Compound_11096/rh:chebi""}]"	"[{""id"": ""RHEA:45145"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 45145 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-013_ada6200493e2	CHEBI:15377	pathwaymech:consumes	RHEA:45145	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45145	This is a side of the single terminal net reaction. DmdD catalyzes hydration and hydrolysis; methanethiol elimination and subsequent decarboxylation are spontaneous or expected spontaneous steps within that net conversion.	"[{""reference_id"": ""RHEA:45145"", ""source_assertion"": ""Rhea places CHEBI:15377 on the substrates side of directed RHEA:45145, with coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/45145/rh:substrates; http://rdf.rhea-db.org/45144_L/rh:contains2 -> http://rdf.rhea-db.org/Participant_45144_compound_1283/rh:compound -> http://rdf.rhea-db.org/Compound_1283/rh:chebi""}]"	"[{""id"": ""RHEA:45145"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 45145 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-014_ebf7d9c5f74c	RHEA:45145	pathwaymech:produces	CHEBI:16007	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45145	This is a side of the single terminal net reaction. DmdD catalyzes hydration and hydrolysis; methanethiol elimination and subsequent decarboxylation are spontaneous or expected spontaneous steps within that net conversion.	"[{""reference_id"": ""RHEA:45145"", ""source_assertion"": ""Rhea places CHEBI:16007 on the products side of directed RHEA:45145, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/45145/rh:products; http://rdf.rhea-db.org/45144_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_45144_compound_2831/rh:compound -> http://rdf.rhea-db.org/Compound_2831/rh:chebi""}]"	"[{""id"": ""RHEA:45145"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 45145 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-015_7fcd49558043	RHEA:45145	pathwaymech:produces	CHEBI:15343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45145	This is a side of the single terminal net reaction. DmdD catalyzes hydration and hydrolysis; methanethiol elimination and subsequent decarboxylation are spontaneous or expected spontaneous steps within that net conversion.	"[{""reference_id"": ""RHEA:45145"", ""source_assertion"": ""Rhea places CHEBI:15343 on the products side of directed RHEA:45145, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/45145/rh:products; http://rdf.rhea-db.org/45144_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_45144_compound_3952/rh:compound -> http://rdf.rhea-db.org/Compound_3952/rh:chebi""}]"	"[{""id"": ""RHEA:45145"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 45145 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-016_f97228ce7a73	RHEA:45145	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45145	This is a side of the single terminal net reaction. DmdD catalyzes hydration and hydrolysis; methanethiol elimination and subsequent decarboxylation are spontaneous or expected spontaneous steps within that net conversion.	"[{""reference_id"": ""RHEA:45145"", ""source_assertion"": ""Rhea places CHEBI:16526 on the products side of directed RHEA:45145, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/45145/rh:products; http://rdf.rhea-db.org/45144_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_45144_compound_4391/rh:compound -> http://rdf.rhea-db.org/Compound_4391/rh:chebi""}]"	"[{""id"": ""RHEA:45145"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 45145 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-017_673cc29c9e8d	RHEA:45145	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45145	This is a side of the single terminal net reaction. DmdD catalyzes hydration and hydrolysis; methanethiol elimination and subsequent decarboxylation are spontaneous or expected spontaneous steps within that net conversion.	"[{""reference_id"": ""RHEA:45145"", ""source_assertion"": ""Rhea places CHEBI:57287 on the products side of directed RHEA:45145, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/45145/rh:products; http://rdf.rhea-db.org/45144_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_45144_compound_1264/rh:compound -> http://rdf.rhea-db.org/Compound_1264/rh:chebi""}]"	"[{""id"": ""RHEA:45145"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 45145 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-018_a478efb306a2	UniProtKB:Q5LRT0	pathwaymech:enables	RHEA:43053	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-19462|MetaCyc:MONOMER-16783|PMID:21562561|PMID:24443527|UniProtKB:Q5LRT0	DmdB2 (SPO2045) enables MMPA activation as a functional gene-product role. Purified recombinant DSS-3 enzyme was a homodimer by gel filtration; this edge does not assert monomer sufficiency. DmdB1 is a separately characterized isozyme outside this native catalyst projection.	"[{""reference_id"": ""MetaCyc:ENZRXN-19462"", ""source_assertion"": ""The native enzymatic-reaction object assigns MONOMER-16783 to RXN-12571."", ""source_locator"": ""Enzymatic-Reaction[@frameid=\""ENZRXN-19462\""]/enzyme/Protein; reaction/Reaction""}, {""reference_id"": ""MetaCyc:MONOMER-16783"", ""source_assertion"": ""The native protein frame cross-references UniProt Q5LRT0; this establishes the gene-product identity, not a monomeric active assembly."", ""source_locator"": ""Protein[@frameid=\""MONOMER-16783\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}, {""reference_id"": ""UniProtKB:Q5LRT0"", ""source_assertion"": ""The reviewed catalytic-activity annotation assigns RHEA:43052 with experimental evidence ECO:0000269. The selected forward direction is independently read from Rhea."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences; comments[1].reaction.evidences""}, {""reference_id"": ""PMID:21562561"", ""source_assertion"": ""Partially purified native MMPA-CoA ligase identified SPO2045; recombinant expression confirmed activity, with ATP consumption and AMP production."", ""source_locator"": ""Printed p.208, MMPA-CoA ligase purification and recombinant expression paragraphs; Figure 1 p.209""}, {""reference_id"": ""PMID:24443527"", ""source_assertion"": ""SPO2045 is RPO_DmdB2. Purified recombinant DmdB2 has MMPA-CoA ligase activity and a native gel-filtration mass consistent with a dimer."", ""source_locator"": ""Figure 2 caption; Results, DmdBs are dimers with MMPA-CoA ligase activity, section sec3-1; Table 1""}, {""reference_id"": ""UniProtKB:Q5LRT0"", ""source_assertion"": ""The reviewed entry identifies Ruegeria pomeroyi strain ATCC 700808 / DSM 15171 / DSS-3 and taxon 246200."", ""source_locator"": ""organism.scientificName; organism.taxonId; genes""}]"	"[{""id"": ""MetaCyc:ENZRXN-19462"", ""source_sha256"": ""9ef650c2ce9d5b8aecedbc260459675e5101bfce5c7b5e0215726f0d08e75162"", ""source_version"": ""MetaCyc 22.5; original native XML"", ""title"": ""MetaCyc ENZRXN-19462 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-19462""}, {""id"": ""MetaCyc:MONOMER-16783"", ""source_sha256"": ""b8b21fa96005b526587c1ce1f96c64fadb9d4e8369eb30c3a77972ec72dd2695"", ""source_version"": ""MetaCyc 22.5; original native XML"", ""title"": ""MetaCyc MONOMER-16783 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-16783""}, {""id"": ""PMID:21562561"", ""source_sha256"": ""4c7829ec5ff3abf7d4a01828190df05847b1616ca96b6775ef0fe653b5c848e5"", ""source_version"": ""Nature 473, 208-211 (2011); complete six-page author-hosted original PDF"", ""title"": ""Novel pathway for assimilation of dimethylsulphoniopropionate widespread in marine bacteria."", ""url"": ""https://hahana.soest.hawaii.edu/cmoreserver/summercourse/2011/documents/moran_06-06-11/Reisch_et_al_2011.pdf""}, {""id"": ""PMID:24443527"", ""source_sha256"": ""40e9df9c743b322d635f5643fffd75876cd409c099ff1bcce73ff1443b1468b7"", ""source_version"": ""Original full-text PMC HTML retrieved 2026-10-11"", ""title"": ""Regulatory and Functional Diversity of Methylmercaptopropionate Coenzyme A Ligases from the Dimethylsulfoniopropionate Demethylation Pathway in Ruegeria pomeroyi DSS-3 and Other Proteobacteria"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3957724/?pdf=render""}, {""id"": ""UniProtKB:Q5LRT0"", ""source_sha256"": ""62d4d47351ec102bc7ba7e930f622ce1d14854e2dcab5ff8ab8c82b865dbca0c"", ""source_version"": ""2026_03 (2026-09-02)"", ""title"": ""UniProtKB Q5LRT0, Ruegeria pomeroyi DSS-3"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q5LRT0.json""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-019_077ed9e36fe3	UniProtKB:Q5LLW7	pathwaymech:enables	RHEA:52613	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-19463|MetaCyc:MONOMER-16784|PMID:21562561|PMID:34818101|UniProtKB:Q5LLW7	DmdC1 (SPO3804) enables the oxidation in its experimentally supported homodimeric context. Current Rhea specifies a generic ETF acceptor class; this role does not claim that the exact carrier was tested. The 2022 study used recombinant DSS-3 enzyme and artificial electron acceptors.	"[{""reference_id"": ""MetaCyc:ENZRXN-19463"", ""source_assertion"": ""The native enzymatic-reaction object assigns MONOMER-16784 to RXN-12572."", ""source_locator"": ""Enzymatic-Reaction[@frameid=\""ENZRXN-19463\""]/enzyme/Protein; reaction/Reaction""}, {""reference_id"": ""MetaCyc:MONOMER-16784"", ""source_assertion"": ""The native protein frame cross-references UniProt Q5LLW7; this establishes the gene-product identity, not a monomeric active assembly."", ""source_locator"": ""Protein[@frameid=\""MONOMER-16784\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}, {""reference_id"": ""UniProtKB:Q5LLW7"", ""source_assertion"": ""The reviewed catalytic-activity annotation assigns RHEA:52612 with experimental evidence ECO:0000269. The selected forward direction is independently read from Rhea."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences; comments[1].reaction.evidences""}, {""reference_id"": ""PMID:21562561"", ""source_assertion"": ""Recombinant SPO3804 catalyzed MMPA-CoA oxidation. The dmdC mutant could not grow on MMPA, and SPO3804 complementation restored growth. Artificial electron acceptors supported the assay."", ""source_locator"": ""Printed pp.208-209, MMPA-CoA dehydrogenation, recombinant expression and dmdC disruption/complementation paragraphs""}, {""reference_id"": ""PMID:34818101"", ""source_assertion"": ""The cloned DSS-3 SPO3804 enzyme forms a homodimer. Oxidation required PMS plus DCPIP or INT; free FAD, FMN and NADP+ alone did not support activity. An uncharacterized in vivo flavoprotein is inferred."", ""source_locator"": ""Results, Properties of RPO_DmdC1 dehydrogenase, section s2-3 paragraphs 1-2; Materials and Methods, Plasmid construction and expression of recombinant protein, section s3-1""}, {""reference_id"": ""UniProtKB:Q5LLW7"", ""source_assertion"": ""The reviewed entry identifies Ruegeria pomeroyi strain ATCC 700808 / DSM 15171 / DSS-3 and taxon 246200."", ""source_locator"": ""organism.scientificName; organism.taxonId; genes""}]"	"[{""id"": ""MetaCyc:ENZRXN-19463"", ""source_sha256"": ""0d8138606fdafd25140131f08dfaf7da1d3199a30df6583ec3f08ee60bfc1745"", ""source_version"": ""MetaCyc 22.5; original native XML"", ""title"": ""MetaCyc ENZRXN-19463 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-19463""}, {""id"": ""MetaCyc:MONOMER-16784"", ""source_sha256"": ""26535ceabf3e251b4b4f2a5d0a6223c738ffda7988573c72a2a34f35b1a333bc"", ""source_version"": ""MetaCyc 22.5; original native XML"", ""title"": ""MetaCyc MONOMER-16784 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-16784""}, {""id"": ""PMID:21562561"", ""source_sha256"": ""4c7829ec5ff3abf7d4a01828190df05847b1616ca96b6775ef0fe653b5c848e5"", ""source_version"": ""Nature 473, 208-211 (2011); complete six-page author-hosted original PDF"", ""title"": ""Novel pathway for assimilation of dimethylsulphoniopropionate widespread in marine bacteria."", ""url"": ""https://hahana.soest.hawaii.edu/cmoreserver/summercourse/2011/documents/moran_06-06-11/Reisch_et_al_2011.pdf""}, {""id"": ""PMID:34818101"", ""source_sha256"": ""a7ddc96bc82751021b67b1bcea1f68d1596cf82e90e499b9bd7bee7358f2e7e6"", ""source_version"": ""Original full-text PMC HTML retrieved 2026-10-11"", ""title"": ""Substrate Specificity of the 3-Methylmercaptopropionyl Coenzyme A Dehydrogenase (DmdC1) from Ruegeria pomeroyi DSS-3"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC8824276/?pdf=render""}, {""id"": ""UniProtKB:Q5LLW7"", ""source_sha256"": ""20c9da5a16f07742e977babfb463eb67c1b243b1b4ddc70b03e34375119092c5"", ""source_version"": ""2026_03 (2026-09-02)"", ""title"": ""UniProtKB Q5LLW7, Ruegeria pomeroyi DSS-3"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q5LLW7.json""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-020_f53b0ba7db06	UniProtKB:Q5LLW6	pathwaymech:enables	RHEA:45145	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-19464|MetaCyc:MONOMER-16785|PMID:21562561|PMID:23704947|UniProtKB:Q5LLW6	DmdD (SPO3805) enables the observed net cleavage as a homohexamer (dimer of trimers), not an isolated monomer. The net equation includes spontaneous methanethiol elimination after hydration and expected spontaneous malonate-semialdehyde decarboxylation. It is not duplicated by component reaction nodes.	"[{""reference_id"": ""MetaCyc:ENZRXN-19464"", ""source_assertion"": ""The native enzymatic-reaction object assigns MONOMER-16785 to RXN-12573."", ""source_locator"": ""Enzymatic-Reaction[@frameid=\""ENZRXN-19464\""]/enzyme/Protein; reaction/Reaction""}, {""reference_id"": ""MetaCyc:MONOMER-16785"", ""source_assertion"": ""The native protein frame cross-references UniProt Q5LLW6; this establishes the gene-product identity, not a monomeric active assembly."", ""source_locator"": ""Protein[@frameid=\""MONOMER-16785\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}, {""reference_id"": ""UniProtKB:Q5LLW6"", ""source_assertion"": ""The reviewed catalytic-activity annotation assigns RHEA:45144 with experimental evidence ECO:0000269. The selected forward direction is independently read from Rhea."", ""source_locator"": ""comments[1].reaction.reactionCrossReferences; comments[1].reaction.evidences""}, {""reference_id"": ""PMID:21562561"", ""source_assertion"": ""Purified DmdD/SPO3805 and recombinant expression establish MTA-CoA cleavage; stoichiometric CoA and methanethiol and approximately 90% theoretical acetaldehyde were obtained. Lost carbon was presumed to be CO2."", ""source_locator"": ""Printed pp.208-209, DmdD purification and product-identification paragraphs; Figure 1""}, {""reference_id"": ""PMID:23704947"", ""source_assertion"": ""DmdD is a homohexamer with two trimers and intersubunit active sites. The mechanism assigns enzymatic hydration and thioester hydrolysis; methanethiol release is spontaneous and final decarboxylation is expected spontaneous."", ""source_locator"": ""Results and Discussion, The hexamer of DmdD (s2b), and Catalytic mechanism of DmdD (s2g); Figure 6""}, {""reference_id"": ""UniProtKB:Q5LLW6"", ""source_assertion"": ""The reviewed entry identifies Ruegeria pomeroyi strain ATCC 700808 / DSM 15171 / DSS-3 and taxon 246200."", ""source_locator"": ""organism.scientificName; organism.taxonId; genes""}]"	"[{""id"": ""MetaCyc:ENZRXN-19464"", ""source_sha256"": ""f2d5f52729685fef1fe2ce07d06c4dbc56dd6ef54720478fc1fe8b5996c70f94"", ""source_version"": ""MetaCyc 22.5; original native XML"", ""title"": ""MetaCyc ENZRXN-19464 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-19464""}, {""id"": ""MetaCyc:MONOMER-16785"", ""source_sha256"": ""cfdd05a5d1c900a38b15b45544c4c6d0e652124d53f0a0b09fa31e38a6e698c0"", ""source_version"": ""MetaCyc 22.5; original native XML"", ""title"": ""MetaCyc MONOMER-16785 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-16785""}, {""id"": ""PMID:21562561"", ""source_sha256"": ""4c7829ec5ff3abf7d4a01828190df05847b1616ca96b6775ef0fe653b5c848e5"", ""source_version"": ""Nature 473, 208-211 (2011); complete six-page author-hosted original PDF"", ""title"": ""Novel pathway for assimilation of dimethylsulphoniopropionate widespread in marine bacteria."", ""url"": ""https://hahana.soest.hawaii.edu/cmoreserver/summercourse/2011/documents/moran_06-06-11/Reisch_et_al_2011.pdf""}, {""id"": ""PMID:23704947"", ""source_sha256"": ""e4a46902318434ca8d53e870579a494dea723bf59a32220ef0fb590025e7d9d5"", ""source_version"": ""PLOS ONE 8:e63870 (2013); original full-text JATS"", ""title"": ""Crystal Structure of DmdD, a Crotonase Superfamily Enzyme That Catalyzes the Hydration and Hydrolysis of Methylthioacryloyl-CoA"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3660561/fullTextXML""}, {""id"": ""UniProtKB:Q5LLW6"", ""source_sha256"": ""f9fc8676edbce8e3b01c2bc534b1dd60cdf2896ac9795110a9fecd1dc8e5c9a2"", ""source_version"": ""2026_03 (2026-09-02)"", ""title"": ""UniProtKB Q5LLW6, Ruegeria pomeroyi DSS-3"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q5LLW6.json""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-021_d2ed1f6c2b19	UniProtKB:Q5LRT0	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:24443527|UniProtKB:Q5LRT0	Magnesium dependence is reported for ligase activity. The sources do not establish an independent protein-binding stoichiometry or separate MgATP and free-ion mechanisms.	"[{""reference_id"": ""UniProtKB:Q5LRT0"", ""source_assertion"": ""The Mg(2+) cofactor annotation is inferred by similarity, ECO:0000250 from Q5SKN9."", ""source_locator"": ""comments[2].cofactors[0].cofactorCrossReference; comments[2].cofactors[0].evidences""}, {""reference_id"": ""PMID:24443527"", ""source_assertion"": ""The primary DmdB study explicitly states that Mg2+ was required for activity; divalent cations were consequently not tested in the salt-response experiment."", ""source_locator"": ""Results, DmdBs show various activities in the presence of salts, section sec3-2 paragraph 1""}]"	"[{""id"": ""PMID:24443527"", ""source_sha256"": ""40e9df9c743b322d635f5643fffd75876cd409c099ff1bcce73ff1443b1468b7"", ""source_version"": ""Original full-text PMC HTML retrieved 2026-10-11"", ""title"": ""Regulatory and Functional Diversity of Methylmercaptopropionate Coenzyme A Ligases from the Dimethylsulfoniopropionate Demethylation Pathway in Ruegeria pomeroyi DSS-3 and Other Proteobacteria"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3957724/?pdf=render""}, {""id"": ""UniProtKB:Q5LRT0"", ""source_sha256"": ""62d4d47351ec102bc7ba7e930f622ce1d14854e2dcab5ff8ab8c82b865dbca0c"", ""source_version"": ""2026_03 (2026-09-02)"", ""title"": ""UniProtKB Q5LRT0, Ruegeria pomeroyi DSS-3"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q5LRT0.json""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-022_496e56aeaa01	UniProtKB:Q5LLW7	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q5LLW7	The enzyme-bound FAD assignment is similarity-scoped and distinct from the generic whole ETF substrate. Free FAD did not act as the sole electron acceptor in the DSS-3 DmdC1 assay; cross-species DmdC activity with free FAD is not transferred here.	"[{""reference_id"": ""UniProtKB:Q5LLW7"", ""source_assertion"": ""FAD cofactor assignment is ECO:0000250, inferred by similarity to A3SI50; it is not a directly measured DSS-3 occupancy or stoichiometry."", ""source_locator"": ""comments[2].cofactors[0].cofactorCrossReference; comments[2].cofactors[0].evidences""}]"	"[{""id"": ""UniProtKB:Q5LLW7"", ""source_sha256"": ""20c9da5a16f07742e977babfb463eb67c1b243b1b4ddc70b03e34375119092c5"", ""source_version"": ""2026_03 (2026-09-02)"", ""title"": ""UniProtKB Q5LLW7, Ruegeria pomeroyi DSS-3"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q5LLW7.json""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-023_ce8b0fc4e9b9	CHEBI:16457	pathwaymech:inhibits	UniProtKB:Q5LRT0	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:24443527|UniProtKB:Q5LRT0	The physiological regulatory model is proposed from measured in vitro inhibition and cellular DMSP context; no direct regulator binding or universal in vivo flux assertion is made.	"[{""reference_id"": ""PMID:24443527"", ""source_assertion"": ""DMSP strongly inhibits RPO_DmdB2, with the plotted concentration response measured using purified recombinant enzyme. This is an in vitro enzyme effect, not a transcription-factor claim."", ""source_locator"": ""Results, DMSP inhibition of marine DmdBs, section sec3-5; Figure 3""}, {""reference_id"": ""UniProtKB:Q5LRT0"", ""source_assertion"": ""The DmdB2 activity-regulation annotation states inhibition by DMSP, with experimental evidence ECO:0000269 from PMID:24443527."", ""source_locator"": ""comments[3].texts[0]""}]"	"[{""id"": ""PMID:24443527"", ""source_sha256"": ""40e9df9c743b322d635f5643fffd75876cd409c099ff1bcce73ff1443b1468b7"", ""source_version"": ""Original full-text PMC HTML retrieved 2026-10-11"", ""title"": ""Regulatory and Functional Diversity of Methylmercaptopropionate Coenzyme A Ligases from the Dimethylsulfoniopropionate Demethylation Pathway in Ruegeria pomeroyi DSS-3 and Other Proteobacteria"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3957724/?pdf=render""}, {""id"": ""UniProtKB:Q5LRT0"", ""source_sha256"": ""62d4d47351ec102bc7ba7e930f622ce1d14854e2dcab5ff8ab8c82b865dbca0c"", ""source_version"": ""2026_03 (2026-09-02)"", ""title"": ""UniProtKB Q5LRT0, Ruegeria pomeroyi DSS-3"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q5LRT0.json""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-024_7f8bddb7e18e	CHEBI:49016	pathwaymech:activates	UniProtKB:Q5LRT0	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:24443527|UniProtKB:Q5LRT0	Conditional relief of DMSP inhibition, not unqualified stimulation in the absence of inhibitor. MMPA is also the substrate of the activation reaction.	"[{""reference_id"": ""PMID:24443527"", ""source_assertion"": ""MMPA above 2 mM relieves DMSP inhibition of RPO_DmdB2; about 80% activity is regained at 8 mM MMPA. ADP relief belongs to DmdB1 and is not transferred to DmdB2."", ""source_locator"": ""Results, ADP and MMPA relieved inhibition by DMSP in R. pomeroyi DSS-3, section sec3-6 paragraph 1; Figure 5B""}, {""reference_id"": ""UniProtKB:Q5LRT0"", ""source_assertion"": ""The DmdB2 annotation records MMPA-dependent relief of DMSP inhibition, with ECO:0000269 from PMID:24443527."", ""source_locator"": ""comments[3].texts[0]""}]"	"[{""id"": ""PMID:24443527"", ""source_sha256"": ""40e9df9c743b322d635f5643fffd75876cd409c099ff1bcce73ff1443b1468b7"", ""source_version"": ""Original full-text PMC HTML retrieved 2026-10-11"", ""title"": ""Regulatory and Functional Diversity of Methylmercaptopropionate Coenzyme A Ligases from the Dimethylsulfoniopropionate Demethylation Pathway in Ruegeria pomeroyi DSS-3 and Other Proteobacteria"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3957724/?pdf=render""}, {""id"": ""UniProtKB:Q5LRT0"", ""source_sha256"": ""62d4d47351ec102bc7ba7e930f622ce1d14854e2dcab5ff8ab8c82b865dbca0c"", ""source_version"": ""2026_03 (2026-09-02)"", ""title"": ""UniProtKB Q5LRT0, Ruegeria pomeroyi DSS-3"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q5LRT0.json""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-025_5298883bd493	RHEA:43053	BFO:0000050	MetaCyc:PWY-6048	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6048|MetaCyc:RXN-12571|RHEA:43053		"[{""reference_id"": ""MetaCyc:PWY-6048"", ""source_assertion"": ""The exact native pathway reaction-list includes RXN-12571. This is one of three complete native members."", ""source_locator"": ""Pathway[@frameid=\""PWY-6048\""]/reaction-list/Reaction""}, {""reference_id"": ""MetaCyc:RXN-12571"", ""source_assertion"": ""The native reaction is physiologically left-to-right and assigns ENZRXN-19462 as its enzymatic reaction."", ""source_locator"": ""Reaction[@frameid=\""RXN-12571\""]/reaction-direction; enzymatic-reaction/Enzymatic-Reaction""}, {""reference_id"": ""RHEA:43053"", ""source_assertion"": ""Rhea master 43052 explicitly links directed reaction 43053 through rh:directionalReaction."", ""source_locator"": ""http://rdf.rhea-db.org/43052/rh:directionalReaction -> http://rdf.rhea-db.org/43053""}, {""reference_id"": ""MetaCyc:RXN-12571"", ""source_assertion"": ""The native reaction directly cross-references RHEA:43053."", ""source_locator"": ""Reaction[@frameid=\""RXN-12571\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}]"	"[{""id"": ""MetaCyc:PWY-6048"", ""source_sha256"": ""66907b705dff00145f524446dc1674f348e27e4632469b4d9accb0f91a3df88e"", ""source_version"": ""MetaCyc 22.5; original native XML"", ""title"": ""MetaCyc PWY-6048 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6048""}, {""id"": ""MetaCyc:RXN-12571"", ""source_sha256"": ""9d5fd03006dff999a5b7f6c48cb7275d92cea6db197fff96ac934a9decf89dad"", ""source_version"": ""MetaCyc 22.5; original native XML"", ""title"": ""MetaCyc RXN-12571 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-12571""}, {""id"": ""RHEA:43053"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 43053 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-026_b023a665ac40	RHEA:52613	BFO:0000050	MetaCyc:PWY-6048	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6048|MetaCyc:RXN-12572|RHEA:52613|UniProtKB:Q5LLW7		"[{""reference_id"": ""MetaCyc:PWY-6048"", ""source_assertion"": ""The exact native pathway reaction-list includes RXN-12572. This is one of three complete native members."", ""source_locator"": ""Pathway[@frameid=\""PWY-6048\""]/reaction-list/Reaction""}, {""reference_id"": ""MetaCyc:RXN-12572"", ""source_assertion"": ""The native reaction is physiologically left-to-right and assigns ENZRXN-19463 as its enzymatic reaction."", ""source_locator"": ""Reaction[@frameid=\""RXN-12572\""]/reaction-direction; enzymatic-reaction/Enzymatic-Reaction""}, {""reference_id"": ""RHEA:52613"", ""source_assertion"": ""Rhea master 52612 explicitly links directed reaction 52613 through rh:directionalReaction."", ""source_locator"": ""http://rdf.rhea-db.org/52612/rh:directionalReaction -> http://rdf.rhea-db.org/52613""}, {""reference_id"": ""UniProtKB:Q5LLW7"", ""source_assertion"": ""The native protein crosswalk resolves the reviewed DmdC entry, whose current catalytic-activity annotation links RHEA:52612. The older native reaction itself does not carry this Rhea cross-reference."", ""source_locator"": ""primaryAccession; comments[1].reaction.reactionCrossReferences""}]"	"[{""id"": ""MetaCyc:PWY-6048"", ""source_sha256"": ""66907b705dff00145f524446dc1674f348e27e4632469b4d9accb0f91a3df88e"", ""source_version"": ""MetaCyc 22.5; original native XML"", ""title"": ""MetaCyc PWY-6048 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6048""}, {""id"": ""MetaCyc:RXN-12572"", ""source_sha256"": ""04a0a61426eab155a17af1b5a19e857e62027bab4a3725321686cc17ad859ef4"", ""source_version"": ""MetaCyc 22.5; original native XML"", ""title"": ""MetaCyc RXN-12572 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-12572""}, {""id"": ""RHEA:52613"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 52613 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:Q5LLW7"", ""source_sha256"": ""20c9da5a16f07742e977babfb463eb67c1b243b1b4ddc70b03e34375119092c5"", ""source_version"": ""2026_03 (2026-09-02)"", ""title"": ""UniProtKB Q5LLW7, Ruegeria pomeroyi DSS-3"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q5LLW7.json""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-027_c63ae13aba79	RHEA:45145	BFO:0000050	MetaCyc:PWY-6048	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6048|MetaCyc:RXN-12573|RHEA:45145	The selected terminal Rhea net includes all four native component transformations and is represented once.	"[{""reference_id"": ""MetaCyc:PWY-6048"", ""source_assertion"": ""The exact native pathway reaction-list includes RXN-12573. This is one of three complete native members."", ""source_locator"": ""Pathway[@frameid=\""PWY-6048\""]/reaction-list/Reaction""}, {""reference_id"": ""MetaCyc:RXN-12573"", ""source_assertion"": ""The native reaction is physiologically left-to-right and assigns ENZRXN-19464 as its enzymatic reaction."", ""source_locator"": ""Reaction[@frameid=\""RXN-12573\""]/reaction-direction; enzymatic-reaction/Enzymatic-Reaction""}, {""reference_id"": ""RHEA:45145"", ""source_assertion"": ""Rhea master 45144 explicitly links directed reaction 45145 through rh:directionalReaction."", ""source_locator"": ""http://rdf.rhea-db.org/45144/rh:directionalReaction -> http://rdf.rhea-db.org/45145""}, {""reference_id"": ""MetaCyc:RXN-12573"", ""source_assertion"": ""The native reaction directly cross-references RHEA:45145."", ""source_locator"": ""Reaction[@frameid=\""RXN-12573\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}]"	"[{""id"": ""MetaCyc:PWY-6048"", ""source_sha256"": ""66907b705dff00145f524446dc1674f348e27e4632469b4d9accb0f91a3df88e"", ""source_version"": ""MetaCyc 22.5; original native XML"", ""title"": ""MetaCyc PWY-6048 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6048""}, {""id"": ""MetaCyc:RXN-12573"", ""source_sha256"": ""27918686fc7d6b0a3489b723a0ba9ecb4128046fa9057fde3ef0affb799dfa24"", ""source_version"": ""MetaCyc 22.5; original native XML"", ""title"": ""MetaCyc RXN-12573 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-12573""}, {""id"": ""RHEA:45145"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 45145 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-028_586cb31bee91	RHEA:43053	RO:0002413	RHEA:52613	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6048|RHEA:43053|RHEA:52613	The shared chemical is CHEBI:82815; this is material continuity, not an assumed regulatory relation.	"[{""reference_id"": ""MetaCyc:PWY-6048"", ""source_assertion"": ""The native reaction-list contains all three activation, oxidation and cleavage transformations. Exact ChEBI intermediate continuity is established separately from both current Rhea sides."", ""source_locator"": ""Pathway[@frameid=\""PWY-6048\""]/reaction-list/Reaction""}, {""reference_id"": ""RHEA:43053"", ""source_assertion"": ""Rhea places CHEBI:82815 on the products side of directed RHEA:43053, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43053/rh:products; http://rdf.rhea-db.org/43052_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_43052_compound_10325/rh:compound -> http://rdf.rhea-db.org/Compound_10325/rh:chebi""}, {""reference_id"": ""RHEA:52613"", ""source_assertion"": ""Rhea places CHEBI:82815 on the substrates side of directed RHEA:52613, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/52613/rh:substrates; http://rdf.rhea-db.org/52612_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_52612_compound_10325/rh:compound -> http://rdf.rhea-db.org/Compound_10325/rh:chebi""}]"	"[{""id"": ""MetaCyc:PWY-6048"", ""source_sha256"": ""66907b705dff00145f524446dc1674f348e27e4632469b4d9accb0f91a3df88e"", ""source_version"": ""MetaCyc 22.5; original native XML"", ""title"": ""MetaCyc PWY-6048 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6048""}, {""id"": ""RHEA:43053"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 43053 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:52613"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 52613 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6048_methylthiopropanoate-edge-029_991618636e66	RHEA:52613	RO:0002413	RHEA:45145	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6048|RHEA:45145|RHEA:52613	The shared chemical is CHEBI:84994; this is material continuity, not an assumed regulatory relation.	"[{""reference_id"": ""MetaCyc:PWY-6048"", ""source_assertion"": ""The native reaction-list contains all three activation, oxidation and cleavage transformations. Exact ChEBI intermediate continuity is established separately from both current Rhea sides."", ""source_locator"": ""Pathway[@frameid=\""PWY-6048\""]/reaction-list/Reaction""}, {""reference_id"": ""RHEA:52613"", ""source_assertion"": ""Rhea places CHEBI:84994 on the products side of directed RHEA:52613, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/52613/rh:products; http://rdf.rhea-db.org/52612_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_52612_compound_11096/rh:compound -> http://rdf.rhea-db.org/Compound_11096/rh:chebi""}, {""reference_id"": ""RHEA:45145"", ""source_assertion"": ""Rhea places CHEBI:84994 on the substrates side of directed RHEA:45145, with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/45145/rh:substrates; http://rdf.rhea-db.org/45144_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_45144_compound_11096/rh:compound -> http://rdf.rhea-db.org/Compound_11096/rh:chebi""}]"	"[{""id"": ""MetaCyc:PWY-6048"", ""source_sha256"": ""66907b705dff00145f524446dc1674f348e27e4632469b4d9accb0f91a3df88e"", ""source_version"": ""MetaCyc 22.5; original native XML"", ""title"": ""MetaCyc PWY-6048 native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6048""}, {""id"": ""RHEA:45145"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 45145 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:52613"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02); complete compressed RDF body"", ""title"": ""Rhea 52613 directed MMPA cleavage reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-001_faca82ba2879	gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_57287_HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/0; endpoint types: /individuals/28/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-002_ad75384c5839	gomodel:MEVALONATE-KINASE-RXN	RO:0002233	CHEBI:36464	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:MEVALONATE-KINASE-RXN RO:0002233 gomodel:CHEBI_36464_1.1.1.34-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/1; endpoint types: /individuals/30/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-003_3d3b7c6d6cf2	SGD:S000005949	pathwaymech:enables	gomodel:ACETYL-COA-ACETYLTRANSFER-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:ACETYL-COA-ACETYLTRANSFER-RXN RO:0002333 gomodel:YPL028W-MONOMER_ACETYL-COA-ACETYLTRANSFER-RXN_controller."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/2; endpoint types: /individuals/0/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-004_1d88638c947a	gomodel:1.1.1.34-RXN	RO:0002233	CHEBI:43074	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:1.1.1.34-RXN RO:0002233 gomodel:CHEBI_43074_HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/3; endpoint types: /individuals/94/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-005_64acd9895cc2	gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_15378_HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/4; endpoint types: /individuals/28/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-006_02304ae05844	SGD:S000004821	pathwaymech:enables	gomodel:MEVALONATE-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:MEVALONATE-KINASE-RXN RO:0002333 gomodel:YMR208W-MONOMER_MEVALONATE-KINASE-RXN_controller."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/5; endpoint types: /individuals/30/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-007_a0ac07c9ba0d	gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN	RO:0002234	CHEBI:128769	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_128769_DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/6; endpoint types: /individuals/27/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-008_2e37452230a1	gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN	RO:0002233	CHEBI:57557	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN RO:0002233 gomodel:CHEBI_57557_PHOSPHOMEVALONATE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/7; endpoint types: /individuals/27/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-009_2300e397c48a	gomodel:PHOSPHOMEVALONATE-KINASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOMEVALONATE-KINASE-RXN BFO:0000066 gomodel:reaction_PHOSPHOMEVALONATE-KINASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/8; endpoint types: /individuals/31/type; /individuals/93/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-010_e66ef2f27c84	gomodel:ACETYL-COA-ACETYLTRANSFER-RXN	BFO:0000050	GO:0008299	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:ACETYL-COA-ACETYLTRANSFER-RXN BFO:0000050 gomodel:YeastPathways_IPPSYN-PWY/YeastPathways_IPPSYN-PWY."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/9; endpoint types: /individuals/0/type; /individuals/95/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-011_8c758e2d2d8b	gomodel:PHOSPHOMEVALONATE-KINASE-RXN	RO:0002234	CHEBI:57557	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOMEVALONATE-KINASE-RXN RO:0002234 gomodel:CHEBI_57557_PHOSPHOMEVALONATE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/10; endpoint types: /individuals/31/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-012_cc1edb2f973c	gomodel:IPPISOM-RXN	BFO:0000050	GO:0008299	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:IPPISOM-RXN BFO:0000050 gomodel:YeastPathways_IPPSYN-PWY/YeastPathways_IPPSYN-PWY."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/11; endpoint types: /individuals/29/type; /individuals/95/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-013_91b67fb8b2e0	gomodel:MEVALONATE-KINASE-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:MEVALONATE-KINASE-RXN RO:0002234 gomodel:CHEBI_456216_MEVALONATE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/12; endpoint types: /individuals/30/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-014_df0f8ca308b9	gomodel:ACETYL-COA-ACETYLTRANSFER-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:ACETYL-COA-ACETYLTRANSFER-RXN BFO:0000066 gomodel:reaction_ACETYL-COA-ACETYLTRANSFER-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/13; endpoint types: /individuals/0/type; /individuals/88/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-016_8beea72362d9	SGD:S000005326	pathwaymech:enables	gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN RO:0002333 gomodel:YNR043W-MONOMER_DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN_controller."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/15; endpoint types: /individuals/27/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-017_fc1c33995e76	gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN	RO:0002234	CHEBI:43074	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_43074_HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/16; endpoint types: /individuals/28/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-018_19317a7ec572	gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN	BFO:0000050	GO:0008299	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN BFO:0000050 gomodel:YeastPathways_IPPSYN-PWY/YeastPathways_IPPSYN-PWY."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/17; endpoint types: /individuals/27/type; /individuals/95/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-019_2c5fb86c8841	gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN BFO:0000066 gomodel:reaction_HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/18; endpoint types: /individuals/28/type; /individuals/90/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-020_568bb8b53be2	gomodel:1.1.1.34-RXN	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:1.1.1.34-RXN RO:0002234 gomodel:CHEBI_57287_1.1.1.34-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/19; endpoint types: /individuals/94/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-021_d5478cc5d819	SGD:S000006038	pathwaymech:enables	gomodel:IPPISOM-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:IPPISOM-RXN RO:0002333 gomodel:YPL117C-MONOMER_IPPISOM-RXN_controller."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/20; endpoint types: /individuals/29/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-022_c10bc7c33da4	gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_43474_DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/21; endpoint types: /individuals/27/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-023_571dae6db9ac	gomodel:MEVALONATE-KINASE-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:MEVALONATE-KINASE-RXN RO:0002233 gomodel:CHEBI_30616_MEVALONATE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/22; endpoint types: /individuals/30/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-024_c2a90b6c814b	gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN	RO:0002233	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_57288_HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/23; endpoint types: /individuals/28/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-025_6a9f69bab429	gomodel:PHOSPHOMEVALONATE-KINASE-RXN	RO:0002233	CHEBI:58146	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOMEVALONATE-KINASE-RXN RO:0002233 gomodel:CHEBI_58146_MEVALONATE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/24; endpoint types: /individuals/31/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-026_dd0e81b048ac	SGD:S000004442	pathwaymech:enables	gomodel:1.1.1.34-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:1.1.1.34-RXN RO:0002333 gomodel:YLR450W-MONOMER_1.1.1.34-RXN_controller."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/25; endpoint types: /individuals/94/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-027_4140ca3b9da8	gomodel:MEVALONATE-KINASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:MEVALONATE-KINASE-RXN RO:0002234 gomodel:CHEBI_15378_MEVALONATE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/26; endpoint types: /individuals/30/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-028_b1409db5692f	gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN	RO:0002233	CHEBI:57286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_57286_ACETYL-COA-ACETYLTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/27; endpoint types: /individuals/28/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-029_45d8ef8579bb	SGD:S000004833	pathwaymech:enables	gomodel:PHOSPHOMEVALONATE-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOMEVALONATE-KINASE-RXN RO:0002333 gomodel:YMR220W-MONOMER_PHOSPHOMEVALONATE-KINASE-RXN_controller."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/28; endpoint types: /individuals/31/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-030_99741f3d2708	gomodel:PHOSPHOMEVALONATE-KINASE-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOMEVALONATE-KINASE-RXN RO:0002233 gomodel:CHEBI_30616_PHOSPHOMEVALONATE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/29; endpoint types: /individuals/31/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-031_2daf952568ed	gomodel:IPPISOM-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:IPPISOM-RXN BFO:0000066 gomodel:reaction_IPPISOM-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/30; endpoint types: /individuals/29/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-032_d9eb057b0402	gomodel:ACETYL-COA-ACETYLTRANSFER-RXN	RO:0002234	CHEBI:57286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:ACETYL-COA-ACETYLTRANSFER-RXN RO:0002234 gomodel:CHEBI_57286_ACETYL-COA-ACETYLTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/31; endpoint types: /individuals/0/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-033_6bb3436946e6	gomodel:PHOSPHOMEVALONATE-KINASE-RXN	BFO:0000050	GO:0008299	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOMEVALONATE-KINASE-RXN BFO:0000050 gomodel:YeastPathways_IPPSYN-PWY/YeastPathways_IPPSYN-PWY."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/32; endpoint types: /individuals/31/type; /individuals/95/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-034_2e1a43a976c2	SGD:S000004540	pathwaymech:enables	gomodel:1.1.1.34-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:1.1.1.34-RXN RO:0002333 gomodel:YML075C-MONOMER_1.1.1.34-RXN_controller."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/33; endpoint types: /individuals/94/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-035_8c2253e17c95	gomodel:PHOSPHOMEVALONATE-KINASE-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:PHOSPHOMEVALONATE-KINASE-RXN RO:0002234 gomodel:CHEBI_456216_PHOSPHOMEVALONATE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/34; endpoint types: /individuals/31/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-036_378147fbf4d6	gomodel:ACETYL-COA-ACETYLTRANSFER-RXN	RO:0002233	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:ACETYL-COA-ACETYLTRANSFER-RXN RO:0002233 gomodel:CHEBI_57288_ACETYL-COA-ACETYLTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/35; endpoint types: /individuals/0/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-037_b726bba73e62	gomodel:1.1.1.34-RXN	RO:0002234	CHEBI:36464	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:1.1.1.34-RXN RO:0002234 gomodel:CHEBI_36464_1.1.1.34-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/36; endpoint types: /individuals/94/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-038_ac0b9a005c81	gomodel:IPPISOM-RXN	RO:0002233	CHEBI:128769	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:IPPISOM-RXN RO:0002233 gomodel:CHEBI_128769_DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/37; endpoint types: /individuals/29/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-039_aa2322ad4a5d	gomodel:1.1.1.34-RXN	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:1.1.1.34-RXN RO:0002234 gomodel:CHEBI_58349_1.1.1.34-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/38; endpoint types: /individuals/94/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-040_29911a970878	gomodel:1.1.1.34-RXN	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:1.1.1.34-RXN RO:0002233 gomodel:CHEBI_57783_1.1.1.34-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/39; endpoint types: /individuals/94/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-041_ccc1b5f1c0a6	gomodel:1.1.1.34-RXN	BFO:0000050	GO:0008299	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:1.1.1.34-RXN BFO:0000050 gomodel:YeastPathways_IPPSYN-PWY/YeastPathways_IPPSYN-PWY."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/40; endpoint types: /individuals/94/type; /individuals/95/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-042_d8d795310290	gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_456216_DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/41; endpoint types: /individuals/27/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-043_016e3f9f8caa	gomodel:ACETYL-COA-ACETYLTRANSFER-RXN	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:ACETYL-COA-ACETYLTRANSFER-RXN RO:0002234 gomodel:CHEBI_57287_ACETYL-COA-ACETYLTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/42; endpoint types: /individuals/0/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-044_1a2ff252fc1b	gomodel:IPPISOM-RXN	RO:0002234	CHEBI:57623	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:IPPISOM-RXN RO:0002234 gomodel:CHEBI_57623_IPPISOM-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/43; endpoint types: /individuals/29/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-045_9b96c24f615d	gomodel:1.1.1.34-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:1.1.1.34-RXN RO:0002233 gomodel:CHEBI_15378_1.1.1.34-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/44; endpoint types: /individuals/94/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-046_da4603724405	gomodel:MEVALONATE-KINASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:MEVALONATE-KINASE-RXN BFO:0000066 gomodel:reaction_MEVALONATE-KINASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/45; endpoint types: /individuals/30/type; /individuals/92/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-047_27c56e08afb4	gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN BFO:0000066 gomodel:reaction_DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/46; endpoint types: /individuals/27/type; /individuals/89/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-048_6e690d5e26a8	gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN	BFO:0000050	GO:0008299	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN BFO:0000050 gomodel:YeastPathways_IPPSYN-PWY/YeastPathways_IPPSYN-PWY."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/47; endpoint types: /individuals/28/type; /individuals/95/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-049_8d82ae94a505	SGD:S000004595	pathwaymech:enables	gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN RO:0002333 gomodel:YML126C-MONOMER_HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN_controller."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/48; endpoint types: /individuals/28/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-050_2c874cc96eb3	gomodel:MEVALONATE-KINASE-RXN	BFO:0000050	GO:0008299	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:MEVALONATE-KINASE-RXN BFO:0000050 gomodel:YeastPathways_IPPSYN-PWY/YeastPathways_IPPSYN-PWY."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/49; endpoint types: /individuals/30/type; /individuals/95/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-051_9b8dcd2290ee	gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_16526_DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/50; endpoint types: /individuals/27/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-052_708eb5318a51	gomodel:MEVALONATE-KINASE-RXN	RO:0002234	CHEBI:58146	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:MEVALONATE-KINASE-RXN RO:0002234 gomodel:CHEBI_58146_MEVALONATE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/51; endpoint types: /individuals/30/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-053_c608bec5f8d3	gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_15377_HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/52; endpoint types: /individuals/28/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_edge-054_0e2d1944701c	gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_IPPSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN RO:0002233 gomodel:CHEBI_30616_DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_IPPSYN-PWY.json#/facts/53; endpoint types: /individuals/27/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_IPPSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json"", ""title"": ""SGD GO-CAM mevalonate pathway model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_location-0805ea80ed30_5212cd890e55	SGD:S000005949	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41338	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:5571830)	"[{""reference_id"": ""UniProtKB:P41338"", ""source_assertion"": ""UniProtKB:P41338 annotates location Cytoplasm, cytosol (SL-0091)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1800/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P41338"", ""source_assertion"": ""UniProtKB:P41338 has the exact SGD cross-reference SGD:S000005949."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1800/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P41338"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41338 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_location-4225850d44ad_5b95de8b44a0	SGD:S000004821	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07277	Physical protein location from reviewed UniProt. ECO:0000305 (PubMed:1645230)	"[{""reference_id"": ""UniProtKB:P07277"", ""source_assertion"": ""UniProtKB:P07277 annotates location Cytoplasm, cytosol (SL-0091)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/183/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07277"", ""source_assertion"": ""UniProtKB:P07277 has the exact SGD cross-reference SGD:S000004821."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/183/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07277"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07277 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_location-ef91d336c5e1_f7ece41bdcb3	SGD:S000006038	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15496	Physical protein location from reviewed UniProt. ECO:0000305	"[{""reference_id"": ""UniProtKB:P15496"", ""source_assertion"": ""UniProtKB:P15496 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/417/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P15496"", ""source_assertion"": ""UniProtKB:P15496 has the exact SGD cross-reference SGD:S000006038."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/417/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P15496"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P15496 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_location-0d20eb3ad577_f5632bee1170	SGD:S000004442	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P12684	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:8744950) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P12684"", ""source_assertion"": ""UniProtKB:P12684 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/347/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P12684"", ""source_assertion"": ""UniProtKB:P12684 has the exact SGD cross-reference SGD:S000004442."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/347/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P12684"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P12684 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_location-0889dab48415_06e3e0087e32	SGD:S000004442	RO:0001025	GO:0005635	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P12684	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P12684"", ""source_assertion"": ""UniProtKB:P12684 annotates location Nucleus envelope (SL-0178)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/347/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P12684"", ""source_assertion"": ""UniProtKB:P12684 has the exact SGD cross-reference SGD:S000004442."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/347/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P12684"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P12684 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_location-22ffdd18424b_3afd9f2db5fe	SGD:S000004833	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P24521	Physical protein location from reviewed UniProt. ECO:0000305 (PubMed:1846667)	"[{""reference_id"": ""UniProtKB:P24521"", ""source_assertion"": ""UniProtKB:P24521 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3348/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P24521"", ""source_assertion"": ""UniProtKB:P24521 has the exact SGD cross-reference SGD:S000004833."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3348/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P24521"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P24521 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_location-085d82bf8d40_3af28ea7d216	SGD:S000004540	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P12683	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:8744950) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P12683"", ""source_assertion"": ""UniProtKB:P12683 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/346/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P12683"", ""source_assertion"": ""UniProtKB:P12683 has the exact SGD cross-reference SGD:S000004540."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/346/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P12683"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P12683 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_location-a60fdd6fbbe8_a44781153766	SGD:S000004540	RO:0001025	GO:0005635	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P12683	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P12683"", ""source_assertion"": ""UniProtKB:P12683 annotates location Nucleus envelope (SL-0178)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/346/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P12683"", ""source_assertion"": ""UniProtKB:P12683 has the exact SGD cross-reference SGD:S000004540."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/346/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P12683"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P12683 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_cofactor-f1f229eca1b9_b5d167634b76	SGD:S000004821	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07277	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P17256)	"[{""reference_id"": ""UniProtKB:P07277"", ""source_assertion"": ""UniProtKB:P07277 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/183/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P07277"", ""source_assertion"": ""UniProtKB:P07277 has the exact SGD cross-reference SGD:S000004821."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/183/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P07277"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07277 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_IPPSYN-PWY_cofactor-7a2ce58769da_50874eab23a4	SGD:S000006038	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15496	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q46822) Binds 1 Mg(2+) ion per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:Q46822)	"[{""reference_id"": ""UniProtKB:P15496"", ""source_assertion"": ""UniProtKB:P15496 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/417/comments/0/cofactors/0; /results/417/comments/0/note""}, {""reference_id"": ""UniProtKB:P15496"", ""source_assertion"": ""UniProtKB:P15496 has the exact SGD cross-reference SGD:S000006038."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/417/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P15496"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P15496 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-001_86978cd176bc	RHEA-COMP:12158	pathwaymech:consumes	RHEA:17458	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17457	Coefficient 1 in the selected biosynthetic direction. This is the whole protein carrier state; its chemically modified residue is not a free metabolite.	"[{""reference_id"": ""RHEA:17457"", ""source_assertion"": ""RHEA:17458 substrates contain RHEA-COMP:12158 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17458 rh:substrates; http://rdf.rhea-db.org/17457_L rh:contains1 http://rdf.rhea-db.org/Participant_17457_compound_12158; rh:compound http://rdf.rhea-db.org/Compound_12158""}]"	"[{""id"": ""RHEA:17457"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 17457"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-002_14d0752f4adb	CHEBI:35235	pathwaymech:consumes	RHEA:17458	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17457	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:17457"", ""source_assertion"": ""RHEA:17458 substrates contain CHEBI:35235 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17458 rh:substrates; http://rdf.rhea-db.org/17457_L rh:contains1 http://rdf.rhea-db.org/Participant_17457_compound_2467; rh:compound http://rdf.rhea-db.org/Compound_2467""}]"	"[{""id"": ""RHEA:17457"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 17457"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-003_f4786c701fd6	RHEA:17458	pathwaymech:produces	RHEA-COMP:12157	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17457	Coefficient 1 in the selected biosynthetic direction. This is the whole protein carrier state; its chemically modified residue is not a free metabolite.	"[{""reference_id"": ""RHEA:17457"", ""source_assertion"": ""RHEA:17458 products contain RHEA-COMP:12157 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17458 rh:products; http://rdf.rhea-db.org/17457_R rh:contains1 http://rdf.rhea-db.org/Participant_17457_compound_12157; rh:compound http://rdf.rhea-db.org/Compound_12157""}]"	"[{""id"": ""RHEA:17457"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 17457"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-004_c28850d3f2cb	RHEA:17458	pathwaymech:produces	CHEBI:57972	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17457	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:17457"", ""source_assertion"": ""RHEA:17458 products contain CHEBI:57972 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17458 rh:products; http://rdf.rhea-db.org/17457_R rh:contains1 http://rdf.rhea-db.org/Participant_17457_compound_3361; rh:compound http://rdf.rhea-db.org/Compound_3361""}]"	"[{""id"": ""RHEA:17457"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 17457"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-005_4b8445e1e541	RHEA-COMP:19907	pathwaymech:consumes	RHEA:26334	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26333	Coefficient 2 in the selected biosynthetic direction. This is the whole protein carrier state; its chemically modified residue is not a free metabolite.	"[{""reference_id"": ""RHEA:26333"", ""source_assertion"": ""RHEA:26334 substrates contain RHEA-COMP:19907 with coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/26334 rh:substrates; http://rdf.rhea-db.org/26333_L rh:contains2 http://rdf.rhea-db.org/Participant_26333_compound_19907; rh:compound http://rdf.rhea-db.org/Compound_19907""}]"	"[{""id"": ""RHEA:26333"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 26333"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-006_153d5ea70753	CHEBI:59648	pathwaymech:consumes	RHEA:26334	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26333	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:26333"", ""source_assertion"": ""RHEA:26334 substrates contain CHEBI:59648 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26334 rh:substrates; http://rdf.rhea-db.org/26333_L rh:contains1 http://rdf.rhea-db.org/Participant_26333_compound_5980; rh:compound http://rdf.rhea-db.org/Compound_5980""}]"	"[{""id"": ""RHEA:26333"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 26333"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-007_5ade25922452	CHEBI:15377	pathwaymech:consumes	RHEA:26334	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26333	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:26333"", ""source_assertion"": ""RHEA:26334 substrates contain CHEBI:15377 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26334 rh:substrates; http://rdf.rhea-db.org/26333_L rh:contains1 http://rdf.rhea-db.org/Participant_26333_compound_1283; rh:compound http://rdf.rhea-db.org/Compound_1283""}]"	"[{""id"": ""RHEA:26333"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 26333"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-008_126d1e44e41e	RHEA:26334	pathwaymech:produces	CHEBI:58698	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26333	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:26333"", ""source_assertion"": ""RHEA:26334 products contain CHEBI:58698 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26334 rh:products; http://rdf.rhea-db.org/26333_R rh:contains1 http://rdf.rhea-db.org/Participant_26333_compound_3616; rh:compound http://rdf.rhea-db.org/Compound_3616""}]"	"[{""id"": ""RHEA:26333"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 26333"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-009_f7460961cc51	RHEA:26334	pathwaymech:produces	RHEA-COMP:12202	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26333	Coefficient 2 in the selected biosynthetic direction. This is the whole protein carrier state; its chemically modified residue is not a free metabolite.	"[{""reference_id"": ""RHEA:26333"", ""source_assertion"": ""RHEA:26334 products contain RHEA-COMP:12202 with coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/26334 rh:products; http://rdf.rhea-db.org/26333_R rh:contains2 http://rdf.rhea-db.org/Participant_26333_compound_12202; rh:compound http://rdf.rhea-db.org/Compound_12202""}]"	"[{""id"": ""RHEA:26333"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 26333"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-010_60f66d618d59	RHEA:26334	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26333	Coefficient 2 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:26333"", ""source_assertion"": ""RHEA:26334 products contain CHEBI:15378 with coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/26334 rh:products; http://rdf.rhea-db.org/26333_R rh:contains2 http://rdf.rhea-db.org/Participant_26333_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249""}]"	"[{""id"": ""RHEA:26333"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 26333"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-011_b7a32fe76bff	CHEBI:58698	pathwaymech:consumes	RHEA:31332	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31331	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:31331"", ""source_assertion"": ""RHEA:31332 substrates contain CHEBI:58698 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31332 rh:substrates; http://rdf.rhea-db.org/31331_L rh:contains1 http://rdf.rhea-db.org/Participant_31331_compound_3616; rh:compound http://rdf.rhea-db.org/Compound_3616""}]"	"[{""id"": ""RHEA:31331"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 31331"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-012_a0ea54a68103	CHEBI:30616	pathwaymech:consumes	RHEA:31332	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31331	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:31331"", ""source_assertion"": ""RHEA:31332 substrates contain CHEBI:30616 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31332 rh:substrates; http://rdf.rhea-db.org/31331_L rh:contains1 http://rdf.rhea-db.org/Participant_31331_compound_6372; rh:compound http://rdf.rhea-db.org/Compound_6372""}]"	"[{""id"": ""RHEA:31331"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 31331"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-013_4768f90b7e18	CHEBI:15378	pathwaymech:consumes	RHEA:31332	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31331	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:31331"", ""source_assertion"": ""RHEA:31332 substrates contain CHEBI:15378 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31332 rh:substrates; http://rdf.rhea-db.org/31331_L rh:contains1 http://rdf.rhea-db.org/Participant_31331_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249""}]"	"[{""id"": ""RHEA:31331"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 31331"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-014_ac177ccf1784	RHEA:31332	pathwaymech:produces	CHEBI:62727	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31331	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:31331"", ""source_assertion"": ""RHEA:31332 products contain CHEBI:62727 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31332 rh:products; http://rdf.rhea-db.org/31331_R rh:contains1 http://rdf.rhea-db.org/Participant_31331_compound_6867; rh:compound http://rdf.rhea-db.org/Compound_6867""}]"	"[{""id"": ""RHEA:31331"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 31331"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-015_4b7ed4b24f43	RHEA:31332	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31331	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:31331"", ""source_assertion"": ""RHEA:31332 products contain CHEBI:33019 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31332 rh:products; http://rdf.rhea-db.org/31331_R rh:contains1 http://rdf.rhea-db.org/Participant_31331_compound_2106; rh:compound http://rdf.rhea-db.org/Compound_2106""}]"	"[{""id"": ""RHEA:31331"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 31331"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-016_913aec4864f9	CHEBI:62727	pathwaymech:consumes	RHEA:35048	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35047	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:35047"", ""source_assertion"": ""RHEA:35048 substrates contain CHEBI:62727 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/35048 rh:substrates; http://rdf.rhea-db.org/35047_L rh:contains1 http://rdf.rhea-db.org/Participant_35047_compound_6867; rh:compound http://rdf.rhea-db.org/Compound_6867""}]"	"[{""id"": ""RHEA:35047"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 35047"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-017_904d2d5cce5f	CHEBI:36264	pathwaymech:consumes	RHEA:35048	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35047	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:35047"", ""source_assertion"": ""RHEA:35048 substrates contain CHEBI:36264 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/35048 rh:substrates; http://rdf.rhea-db.org/35047_L rh:contains1 http://rdf.rhea-db.org/Participant_35047_compound_5442; rh:compound http://rdf.rhea-db.org/Compound_5442""}]"	"[{""id"": ""RHEA:35047"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 35047"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-018_646c1c04fc14	RHEA:35048	pathwaymech:produces	CHEBI:71302	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35047	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:35047"", ""source_assertion"": ""RHEA:35048 products contain CHEBI:71302 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/35048 rh:products; http://rdf.rhea-db.org/35047_R rh:contains1 http://rdf.rhea-db.org/Participant_35047_compound_7664; rh:compound http://rdf.rhea-db.org/Compound_7664""}]"	"[{""id"": ""RHEA:35047"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 35047"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-019_6d2973227754	RHEA:35048	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35047	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:35047"", ""source_assertion"": ""RHEA:35048 products contain CHEBI:456215 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/35048 rh:products; http://rdf.rhea-db.org/35047_R rh:contains1 http://rdf.rhea-db.org/Participant_35047_compound_2590; rh:compound http://rdf.rhea-db.org/Compound_2590""}]"	"[{""id"": ""RHEA:35047"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 35047"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-020_b5df80eed51f	RHEA:35048	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:35047	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:35047"", ""source_assertion"": ""RHEA:35048 products contain CHEBI:15378 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/35048 rh:products; http://rdf.rhea-db.org/35047_R rh:contains1 http://rdf.rhea-db.org/Participant_35047_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249""}]"	"[{""id"": ""RHEA:35047"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 35047"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-021_781dc6f209bb	RHEA-COMP:12202	pathwaymech:consumes	RHEA:43617	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43616	Coefficient 1 in the selected biosynthetic direction. This is the whole protein carrier state; its chemically modified residue is not a free metabolite.	"[{""reference_id"": ""RHEA:43616"", ""source_assertion"": ""RHEA:43617 substrates contain RHEA-COMP:12202 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43617 rh:substrates; http://rdf.rhea-db.org/43616_L rh:contains1 http://rdf.rhea-db.org/Participant_43616_compound_12202; rh:compound http://rdf.rhea-db.org/Compound_12202""}]"	"[{""id"": ""RHEA:43616"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 43616"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-022_01dc7ffee1d4	CHEBI:30616	pathwaymech:consumes	RHEA:43617	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43616	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:43616"", ""source_assertion"": ""RHEA:43617 substrates contain CHEBI:30616 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43617 rh:substrates; http://rdf.rhea-db.org/43616_L rh:contains1 http://rdf.rhea-db.org/Participant_43616_compound_6372; rh:compound http://rdf.rhea-db.org/Compound_6372""}]"	"[{""id"": ""RHEA:43616"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 43616"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-023_85b11dea9379	CHEBI:15378	pathwaymech:consumes	RHEA:43617	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43616	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:43616"", ""source_assertion"": ""RHEA:43617 substrates contain CHEBI:15378 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43617 rh:substrates; http://rdf.rhea-db.org/43616_L rh:contains1 http://rdf.rhea-db.org/Participant_43616_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249""}]"	"[{""id"": ""RHEA:43616"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 43616"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-024_11f6b86c3536	RHEA:43617	pathwaymech:produces	RHEA-COMP:12159	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43616	Coefficient 1 in the selected biosynthetic direction. This is the whole protein carrier state; its chemically modified residue is not a free metabolite.	"[{""reference_id"": ""RHEA:43616"", ""source_assertion"": ""RHEA:43617 products contain RHEA-COMP:12159 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43617 rh:products; http://rdf.rhea-db.org/43616_R rh:contains1 http://rdf.rhea-db.org/Participant_43616_compound_12159; rh:compound http://rdf.rhea-db.org/Compound_12159""}]"	"[{""id"": ""RHEA:43616"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 43616"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-025_80d0bd871e1d	RHEA:43617	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43616	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:43616"", ""source_assertion"": ""RHEA:43617 products contain CHEBI:33019 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43617 rh:products; http://rdf.rhea-db.org/43616_R rh:contains1 http://rdf.rhea-db.org/Participant_43616_compound_2106; rh:compound http://rdf.rhea-db.org/Compound_2106""}]"	"[{""id"": ""RHEA:43616"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 43616"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-026_42cb0b1881b9	RHEA-COMP:12159	pathwaymech:consumes	RHEA:48613	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:48612	Coefficient 1 in the selected biosynthetic direction. This is the whole protein carrier state; its chemically modified residue is not a free metabolite.	"[{""reference_id"": ""RHEA:48612"", ""source_assertion"": ""RHEA:48613 substrates contain RHEA-COMP:12159 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/48613 rh:substrates; http://rdf.rhea-db.org/48612_L rh:contains1 http://rdf.rhea-db.org/Participant_48612_compound_12159; rh:compound http://rdf.rhea-db.org/Compound_12159""}]"	"[{""id"": ""RHEA:48612"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 48612"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-027_cc08342f1b30	RHEA-COMP:12157	pathwaymech:consumes	RHEA:48613	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:48612	Coefficient 1 in the selected biosynthetic direction. This is the whole protein carrier state; its chemically modified residue is not a free metabolite.	"[{""reference_id"": ""RHEA:48612"", ""source_assertion"": ""RHEA:48613 substrates contain RHEA-COMP:12157 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/48613 rh:substrates; http://rdf.rhea-db.org/48612_L rh:contains1 http://rdf.rhea-db.org/Participant_48612_compound_12157; rh:compound http://rdf.rhea-db.org/Compound_12157""}]"	"[{""id"": ""RHEA:48612"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 48612"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-028_1bd2a549067c	CHEBI:17499	pathwaymech:consumes	RHEA:48613	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:48612	Coefficient 1 in the selected biosynthetic direction. The net redox donor/acceptor remains generic; these sources do not identify the physiological electron donor.	"[{""reference_id"": ""RHEA:48612"", ""source_assertion"": ""RHEA:48613 substrates contain CHEBI:17499 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/48613 rh:substrates; http://rdf.rhea-db.org/48612_L rh:contains1 http://rdf.rhea-db.org/Participant_48612_compound_1304; rh:compound http://rdf.rhea-db.org/Compound_1304""}]"	"[{""id"": ""RHEA:48612"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 48612"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-029_324c7024fe66	RHEA:48613	pathwaymech:produces	RHEA-COMP:19907	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:48612	Coefficient 1 in the selected biosynthetic direction. This is the whole protein carrier state; its chemically modified residue is not a free metabolite.	"[{""reference_id"": ""RHEA:48612"", ""source_assertion"": ""RHEA:48613 products contain RHEA-COMP:19907 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/48613 rh:products; http://rdf.rhea-db.org/48612_R rh:contains1 http://rdf.rhea-db.org/Participant_48612_compound_19907; rh:compound http://rdf.rhea-db.org/Compound_19907""}]"	"[{""id"": ""RHEA:48612"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 48612"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-030_27aa9438a8b2	RHEA:48613	pathwaymech:produces	RHEA-COMP:12158	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:48612	Coefficient 1 in the selected biosynthetic direction. This is the whole protein carrier state; its chemically modified residue is not a free metabolite.	"[{""reference_id"": ""RHEA:48612"", ""source_assertion"": ""RHEA:48613 products contain RHEA-COMP:12158 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/48613 rh:products; http://rdf.rhea-db.org/48612_R rh:contains1 http://rdf.rhea-db.org/Participant_48612_compound_12158; rh:compound http://rdf.rhea-db.org/Compound_12158""}]"	"[{""id"": ""RHEA:48612"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 48612"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-031_2f843c41a6d5	RHEA:48613	pathwaymech:produces	CHEBI:13193	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:48612	Coefficient 1 in the selected biosynthetic direction. The net redox donor/acceptor remains generic; these sources do not identify the physiological electron donor.	"[{""reference_id"": ""RHEA:48612"", ""source_assertion"": ""RHEA:48613 products contain CHEBI:13193 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/48613 rh:products; http://rdf.rhea-db.org/48612_R rh:contains1 http://rdf.rhea-db.org/Participant_48612_compound_3512; rh:compound http://rdf.rhea-db.org/Compound_3512""}]"	"[{""id"": ""RHEA:48612"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 48612"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-032_7d127a934a56	RHEA:48613	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:48612	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:48612"", ""source_assertion"": ""RHEA:48613 products contain CHEBI:456215 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/48613 rh:products; http://rdf.rhea-db.org/48612_R rh:contains1 http://rdf.rhea-db.org/Participant_48612_compound_2590; rh:compound http://rdf.rhea-db.org/Compound_2590""}]"	"[{""id"": ""RHEA:48612"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 48612"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-033_ee2cbf46ed58	RHEA:48613	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:48612	Coefficient 2 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:48612"", ""source_assertion"": ""RHEA:48613 products contain CHEBI:15378 with coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/48613 rh:products; http://rdf.rhea-db.org/48612_R rh:contains2 http://rdf.rhea-db.org/Participant_48612_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249""}]"	"[{""id"": ""RHEA:48612"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 48612"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-034_351b1688d23d	CHEBI:37565	pathwaymech:consumes	RHEA:49577	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:49576	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:49576"", ""source_assertion"": ""RHEA:49577 substrates contain CHEBI:37565 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/49577 rh:substrates; http://rdf.rhea-db.org/49576_L rh:contains1 http://rdf.rhea-db.org/Participant_49576_compound_6355; rh:compound http://rdf.rhea-db.org/Compound_6355""}]"	"[{""id"": ""RHEA:49576"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 49576"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-035_579273380e2f	CHEBI:17499	pathwaymech:consumes	RHEA:49577	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:49576	Coefficient 1 in the selected biosynthetic direction. The net redox donor/acceptor remains generic; these sources do not identify the physiological electron donor.	"[{""reference_id"": ""RHEA:49576"", ""source_assertion"": ""RHEA:49577 substrates contain CHEBI:17499 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/49577 rh:substrates; http://rdf.rhea-db.org/49576_L rh:contains1 http://rdf.rhea-db.org/Participant_49576_compound_1304; rh:compound http://rdf.rhea-db.org/Compound_1304""}]"	"[{""id"": ""RHEA:49576"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 49576"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-036_58f2b41a5f79	CHEBI:59789	pathwaymech:consumes	RHEA:49577	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:49576	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:49576"", ""source_assertion"": ""RHEA:49577 substrates contain CHEBI:59789 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/49577 rh:substrates; http://rdf.rhea-db.org/49576_L rh:contains1 http://rdf.rhea-db.org/Participant_49576_compound_6127; rh:compound http://rdf.rhea-db.org/Compound_6127""}]"	"[{""id"": ""RHEA:49576"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 49576"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-037_655e03b0f740	RHEA:49577	pathwaymech:produces	CHEBI:131766	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:49576	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:49576"", ""source_assertion"": ""RHEA:49577 products contain CHEBI:131766 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/49577 rh:products; http://rdf.rhea-db.org/49576_R rh:contains1 http://rdf.rhea-db.org/Participant_49576_compound_12441; rh:compound http://rdf.rhea-db.org/Compound_12441""}]"	"[{""id"": ""RHEA:49576"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 49576"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-038_d91eb0b6012e	RHEA:49577	pathwaymech:produces	CHEBI:17319	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:49576	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:49576"", ""source_assertion"": ""RHEA:49577 products contain CHEBI:17319 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/49577 rh:products; http://rdf.rhea-db.org/49576_R rh:contains1 http://rdf.rhea-db.org/Participant_49576_compound_2028; rh:compound http://rdf.rhea-db.org/Compound_2028""}]"	"[{""id"": ""RHEA:49576"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 49576"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-039_4b7afe659451	RHEA:49577	pathwaymech:produces	CHEBI:57844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:49576	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:49576"", ""source_assertion"": ""RHEA:49577 products contain CHEBI:57844 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/49577 rh:products; http://rdf.rhea-db.org/49576_R rh:contains1 http://rdf.rhea-db.org/Participant_49576_compound_2530; rh:compound http://rdf.rhea-db.org/Compound_2530""}]"	"[{""id"": ""RHEA:49576"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 49576"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-040_1f9dcd89110c	RHEA:49577	pathwaymech:produces	CHEBI:13193	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:49576	Coefficient 1 in the selected biosynthetic direction. The net redox donor/acceptor remains generic; these sources do not identify the physiological electron donor.	"[{""reference_id"": ""RHEA:49576"", ""source_assertion"": ""RHEA:49577 products contain CHEBI:13193 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/49577 rh:products; http://rdf.rhea-db.org/49576_R rh:contains1 http://rdf.rhea-db.org/Participant_49576_compound_3512; rh:compound http://rdf.rhea-db.org/Compound_3512""}]"	"[{""id"": ""RHEA:49576"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 49576"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-041_36d8601ccd22	RHEA:49577	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:49576	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:49576"", ""source_assertion"": ""RHEA:49577 products contain CHEBI:15378 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/49577 rh:products; http://rdf.rhea-db.org/49576_R rh:contains1 http://rdf.rhea-db.org/Participant_49576_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249""}]"	"[{""id"": ""RHEA:49576"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 49576"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-042_b123b336f226	CHEBI:131766	pathwaymech:consumes	RHEA:49581	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:49580	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:49580"", ""source_assertion"": ""RHEA:49581 substrates contain CHEBI:131766 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/49581 rh:substrates; http://rdf.rhea-db.org/49580_L rh:contains1 http://rdf.rhea-db.org/Participant_49580_compound_12441; rh:compound http://rdf.rhea-db.org/Compound_12441""}]"	"[{""id"": ""RHEA:49580"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 49580"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-043_eae5a558f467	RHEA:49581	pathwaymech:produces	CHEBI:59648	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:49580	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:49580"", ""source_assertion"": ""RHEA:49581 products contain CHEBI:59648 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/49581 rh:products; http://rdf.rhea-db.org/49580_R rh:contains1 http://rdf.rhea-db.org/Participant_49580_compound_5980; rh:compound http://rdf.rhea-db.org/Compound_5980""}]"	"[{""id"": ""RHEA:49580"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 49580"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-044_afcfca0a9bab	RHEA:49581	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:49580	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:49580"", ""source_assertion"": ""RHEA:49581 products contain CHEBI:33019 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/49581 rh:products; http://rdf.rhea-db.org/49580_R rh:contains1 http://rdf.rhea-db.org/Participant_49580_compound_2106; rh:compound http://rdf.rhea-db.org/Compound_2106""}]"	"[{""id"": ""RHEA:49580"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 49580"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-045_9315bbcc4cf8	RHEA:49577	BFO:0000050	MetaCyc:PWY-6823	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:131766|MetaCyc:CPD-19179|MetaCyc:PWY-6823|MetaCyc:RXN-8340|RHEA:49576|UniProtKB:P30745	The native pathway reaction is represented in its biosynthetic direction using exact current Rhea chemistry. Native RXN-8340 has a stale RHEA:26378 cross-reference, which denotes the combined GTP-to-cPMP transformation. Its actual cyclic-GTP product and EC 4.1.99.22, together with current MoaA annotation, support the separate cyclase step here.	"[{""reference_id"": ""MetaCyc:PWY-6823"", ""source_assertion"": ""PWY-6823 includes RXN-8340 in its eight-reaction molybdenum-cofactor route."", ""source_locator"": ""/ptools-xml/*[@frameid='PWY-6823']/reaction-list/Reaction[@frameid=\""RXN-8340\""]""}, {""reference_id"": ""RHEA:49576"", ""source_assertion"": ""RHEA:49576 has directional reaction RHEA:49577, selected left-to-right for biosynthesis."", ""source_locator"": ""http://rdf.rhea-db.org/49576 rh:directionalReaction http://rdf.rhea-db.org/49577; http://rdf.rhea-db.org/49577 rh:substrates/rh:products""}, {""reference_id"": ""MetaCyc:RXN-8340"", ""source_assertion"": ""RXN-8340 consumes GTP and produces CPD-19179; EC 4.1.99.22 describes GTP cyclization. Its RHEA:26378 cross-reference is not used as an identity equivalence."", ""source_locator"": ""/ptools-xml/*[@frameid='RXN-8340']/left; right; ec-number; dblink""}, {""reference_id"": ""MetaCyc:CPD-19179"", ""source_assertion"": ""CPD-19179 names (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate; its CML gives C10H12N5O14P3 and charge -4."", ""source_locator"": ""/ptools-xml/Compound[@frameid='CPD-19179']/common-name; cml/molecule/formula; cml/molecule/@formalCharge""}, {""reference_id"": ""UniProtKB:P30745"", ""source_assertion"": ""The reviewed MoaA annotation links EC 4.1.99.22 to RHEA:49576 with ECO:0000255 (HAMAP MF_01225)."", ""source_locator"": ""$.comments[2].reaction""}, {""reference_id"": ""CHEBI:131766"", ""source_assertion"": ""ChEBI:131766 explicitly cross-references metacyc.compound:CPD-19179 and identifies the (8S) cyclic GTP structure, formula C10H12N5O14P3, charge -4."", ""source_locator"": ""ChEBI 255 Semantic SQL statements: subject CHEBI:131766; oio:hasDbXref = metacyc.compound:CPD-19179; rdfs:label; chemrof:generalized_empirical_formula; chemrof:charge""}]"	"[{""id"": ""CHEBI:131766"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL snapshot; SHA-256 of complete preserved database file"", ""title"": ""(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate(4-)"", ""url"": ""https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:131766""}, {""id"": ""MetaCyc:CPD-19179"", ""source_sha256"": ""2374460541bcbe38dfc4994919fc22be9f3771e1926065d625ade502e1bb4d7b"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""CPD-19179"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-19179""}, {""id"": ""MetaCyc:PWY-6823"", ""source_sha256"": ""93a2e4fa02ba082e4094d65e423f3132701a687a6856aa4cf958e685172d477f"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""molybdenum cofactor biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6823""}, {""id"": ""MetaCyc:RXN-8340"", ""source_sha256"": ""d8015bf747296a864b09076c96650d848af1a47dab83529c9f4b36d2df935d9f"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""RXN-8340"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8340""}, {""id"": ""RHEA:49576"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 49576"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P30745"", ""source_sha256"": ""4110615d7d4172284952aa5de98d4cc9a790c5682830a15a013d84fc6d1bc0af"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""GTP 3',8-cyclase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30745.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-046_279b1c1295ed	RHEA:49581	BFO:0000050	MetaCyc:PWY-6823	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6823|MetaCyc:RXN-17809|RHEA:49580	The native pathway reaction is represented in its biosynthetic direction using exact current Rhea chemistry.	"[{""reference_id"": ""MetaCyc:PWY-6823"", ""source_assertion"": ""PWY-6823 includes RXN-17809 in its eight-reaction molybdenum-cofactor route."", ""source_locator"": ""/ptools-xml/*[@frameid='PWY-6823']/reaction-list/Reaction[@frameid=\""RXN-17809\""]""}, {""reference_id"": ""RHEA:49580"", ""source_assertion"": ""RHEA:49580 has directional reaction RHEA:49581, selected left-to-right for biosynthesis."", ""source_locator"": ""http://rdf.rhea-db.org/49580 rh:directionalReaction http://rdf.rhea-db.org/49581; http://rdf.rhea-db.org/49581 rh:substrates/rh:products""}, {""reference_id"": ""MetaCyc:RXN-17809"", ""source_assertion"": ""RXN-17809 explicitly cross-references RHEA:49581; its native left-to-right reaction is selected."", ""source_locator"": ""/ptools-xml/*[@frameid='RXN-17809']/reaction-direction; dblink[dblink-db=\""RHEA\""]""}]"	"[{""id"": ""MetaCyc:PWY-6823"", ""source_sha256"": ""93a2e4fa02ba082e4094d65e423f3132701a687a6856aa4cf958e685172d477f"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""molybdenum cofactor biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6823""}, {""id"": ""MetaCyc:RXN-17809"", ""source_sha256"": ""f522fad1fa46dbe635f820f293f439c49c280fae4c5a88d651f80006edc1b8df"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""RXN-17809"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-17809""}, {""id"": ""RHEA:49580"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 49580"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-047_dd23fbf208ae	RHEA:17458	BFO:0000050	MetaCyc:PWY-6823	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6823|MetaCyc:RXN0-308|RHEA:17457	The native pathway reaction is represented in its biosynthetic direction using exact current Rhea chemistry.	"[{""reference_id"": ""MetaCyc:PWY-6823"", ""source_assertion"": ""PWY-6823 includes RXN0-308 in its eight-reaction molybdenum-cofactor route."", ""source_locator"": ""/ptools-xml/*[@frameid='PWY-6823']/reaction-list/Reaction[@frameid=\""RXN0-308\""]""}, {""reference_id"": ""RHEA:17457"", ""source_assertion"": ""RHEA:17457 has directional reaction RHEA:17458, selected left-to-right for biosynthesis."", ""source_locator"": ""http://rdf.rhea-db.org/17457 rh:directionalReaction http://rdf.rhea-db.org/17458; http://rdf.rhea-db.org/17458 rh:substrates/rh:products""}, {""reference_id"": ""MetaCyc:RXN0-308"", ""source_assertion"": ""RXN0-308 explicitly cross-references RHEA:17458; its native left-to-right reaction is selected."", ""source_locator"": ""/ptools-xml/*[@frameid='RXN0-308']/reaction-direction; dblink[dblink-db=\""RHEA\""]""}]"	"[{""id"": ""MetaCyc:PWY-6823"", ""source_sha256"": ""93a2e4fa02ba082e4094d65e423f3132701a687a6856aa4cf958e685172d477f"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""molybdenum cofactor biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6823""}, {""id"": ""MetaCyc:RXN0-308"", ""source_sha256"": ""b7cfc31659f90f5637ad8ae269cc09868a47e8c7205b2e18398fadaa6331723c"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""RXN0-308"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-308""}, {""id"": ""RHEA:17457"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 17457"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-048_d03cbc9836b4	RHEA:43617	BFO:0000050	MetaCyc:PWY-6823	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6823|MetaCyc:RXN-11361|RHEA:43616	The native pathway reaction is represented in its biosynthetic direction using exact current Rhea chemistry.	"[{""reference_id"": ""MetaCyc:PWY-6823"", ""source_assertion"": ""PWY-6823 includes RXN-11361 in its eight-reaction molybdenum-cofactor route."", ""source_locator"": ""/ptools-xml/*[@frameid='PWY-6823']/reaction-list/Reaction[@frameid=\""RXN-11361\""]""}, {""reference_id"": ""RHEA:43616"", ""source_assertion"": ""RHEA:43616 has directional reaction RHEA:43617, selected left-to-right for biosynthesis."", ""source_locator"": ""http://rdf.rhea-db.org/43616 rh:directionalReaction http://rdf.rhea-db.org/43617; http://rdf.rhea-db.org/43617 rh:substrates/rh:products""}, {""reference_id"": ""MetaCyc:RXN-11361"", ""source_assertion"": ""RXN-11361 explicitly cross-references RHEA:43617; its native left-to-right reaction is selected."", ""source_locator"": ""/ptools-xml/*[@frameid='RXN-11361']/reaction-direction; dblink[dblink-db=\""RHEA\""]""}]"	"[{""id"": ""MetaCyc:PWY-6823"", ""source_sha256"": ""93a2e4fa02ba082e4094d65e423f3132701a687a6856aa4cf958e685172d477f"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""molybdenum cofactor biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6823""}, {""id"": ""MetaCyc:RXN-11361"", ""source_sha256"": ""f37a3040bb9343118821909dadae887b89e585aa4c4cfd4eeada5d9046368938"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""RXN-11361"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11361""}, {""id"": ""RHEA:43616"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 43616"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-049_2d5e8f56bf0c	RHEA:48613	BFO:0000050	MetaCyc:PWY-6823	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6823|MetaCyc:RXN-12473|RHEA:48612	The native pathway reaction is represented in its biosynthetic direction using exact current Rhea chemistry.	"[{""reference_id"": ""MetaCyc:PWY-6823"", ""source_assertion"": ""PWY-6823 includes RXN-12473 in its eight-reaction molybdenum-cofactor route."", ""source_locator"": ""/ptools-xml/*[@frameid='PWY-6823']/reaction-list/Reaction[@frameid=\""RXN-12473\""]""}, {""reference_id"": ""RHEA:48612"", ""source_assertion"": ""RHEA:48612 has directional reaction RHEA:48613, selected left-to-right for biosynthesis."", ""source_locator"": ""http://rdf.rhea-db.org/48612 rh:directionalReaction http://rdf.rhea-db.org/48613; http://rdf.rhea-db.org/48613 rh:substrates/rh:products""}, {""reference_id"": ""MetaCyc:RXN-12473"", ""source_assertion"": ""RXN-12473 explicitly cross-references RHEA:48613; its native left-to-right reaction is selected."", ""source_locator"": ""/ptools-xml/*[@frameid='RXN-12473']/reaction-direction; dblink[dblink-db=\""RHEA\""]""}]"	"[{""id"": ""MetaCyc:PWY-6823"", ""source_sha256"": ""93a2e4fa02ba082e4094d65e423f3132701a687a6856aa4cf958e685172d477f"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""molybdenum cofactor biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6823""}, {""id"": ""MetaCyc:RXN-12473"", ""source_sha256"": ""527c2ed585f80ca8afaa9fb74905ae0c8396d06eeb0961b1886c3d4b89884a8e"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""RXN-12473"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-12473""}, {""id"": ""RHEA:48612"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 48612"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-050_70b045b28c14	RHEA:26334	BFO:0000050	MetaCyc:PWY-6823	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6823|MetaCyc:RXN-8342|RHEA:26333	The native pathway reaction is represented in its biosynthetic direction using exact current Rhea chemistry. The older native equation releases four protons; current Rhea releases two for its defined carrier and ionic forms.	"[{""reference_id"": ""MetaCyc:PWY-6823"", ""source_assertion"": ""PWY-6823 includes RXN-8342 in its eight-reaction molybdenum-cofactor route."", ""source_locator"": ""/ptools-xml/*[@frameid='PWY-6823']/reaction-list/Reaction[@frameid=\""RXN-8342\""]""}, {""reference_id"": ""RHEA:26333"", ""source_assertion"": ""RHEA:26333 has directional reaction RHEA:26334, selected left-to-right for biosynthesis."", ""source_locator"": ""http://rdf.rhea-db.org/26333 rh:directionalReaction http://rdf.rhea-db.org/26334; http://rdf.rhea-db.org/26334 rh:substrates/rh:products""}, {""reference_id"": ""MetaCyc:RXN-8342"", ""source_assertion"": ""RXN-8342 explicitly cross-references RHEA:26334; its native left-to-right reaction is selected."", ""source_locator"": ""/ptools-xml/*[@frameid='RXN-8342']/reaction-direction; dblink[dblink-db=\""RHEA\""]""}]"	"[{""id"": ""MetaCyc:PWY-6823"", ""source_sha256"": ""93a2e4fa02ba082e4094d65e423f3132701a687a6856aa4cf958e685172d477f"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""molybdenum cofactor biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6823""}, {""id"": ""MetaCyc:RXN-8342"", ""source_sha256"": ""a154daf6a1f8f970d6d8c269aa85d9cde5cf5737a54d77ab176885025601504d"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""RXN-8342"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8342""}, {""id"": ""RHEA:26333"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 26333"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-051_c738cebc68ed	RHEA:31332	BFO:0000050	MetaCyc:PWY-6823	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6823|MetaCyc:RXN-8344|RHEA:31331	The native pathway reaction is represented in its biosynthetic direction using exact current Rhea chemistry.	"[{""reference_id"": ""MetaCyc:PWY-6823"", ""source_assertion"": ""PWY-6823 includes RXN-8344 in its eight-reaction molybdenum-cofactor route."", ""source_locator"": ""/ptools-xml/*[@frameid='PWY-6823']/reaction-list/Reaction[@frameid=\""RXN-8344\""]""}, {""reference_id"": ""RHEA:31331"", ""source_assertion"": ""RHEA:31331 has directional reaction RHEA:31332, selected left-to-right for biosynthesis."", ""source_locator"": ""http://rdf.rhea-db.org/31331 rh:directionalReaction http://rdf.rhea-db.org/31332; http://rdf.rhea-db.org/31332 rh:substrates/rh:products""}, {""reference_id"": ""MetaCyc:RXN-8344"", ""source_assertion"": ""RXN-8344 explicitly cross-references RHEA:31332; its native left-to-right reaction is selected."", ""source_locator"": ""/ptools-xml/*[@frameid='RXN-8344']/reaction-direction; dblink[dblink-db=\""RHEA\""]""}]"	"[{""id"": ""MetaCyc:PWY-6823"", ""source_sha256"": ""93a2e4fa02ba082e4094d65e423f3132701a687a6856aa4cf958e685172d477f"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""molybdenum cofactor biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6823""}, {""id"": ""MetaCyc:RXN-8344"", ""source_sha256"": ""865a1c24aab4ae074c783130181f74f750114d90bf7260b54584a39af3a7de95"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""RXN-8344"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8344""}, {""id"": ""RHEA:31331"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 31331"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-052_430decc41dee	RHEA:35048	BFO:0000050	MetaCyc:PWY-6823	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-8123|MetaCyc:PWY-6823|MetaCyc:RXN-8348|RHEA:35047	The native pathway reaction is represented in its biosynthetic direction using exact current Rhea chemistry. The older native product is MoO2-MPT, whereas current Rhea specifies Mo(VI)O2(OH)-MPT; their water/proton accounting is different and is not treated as identical chemistry.	"[{""reference_id"": ""MetaCyc:PWY-6823"", ""source_assertion"": ""PWY-6823 includes RXN-8348 in its eight-reaction molybdenum-cofactor route."", ""source_locator"": ""/ptools-xml/*[@frameid='PWY-6823']/reaction-list/Reaction[@frameid=\""RXN-8348\""]""}, {""reference_id"": ""RHEA:35047"", ""source_assertion"": ""RHEA:35047 has directional reaction RHEA:35048, selected left-to-right for biosynthesis."", ""source_locator"": ""http://rdf.rhea-db.org/35047 rh:directionalReaction http://rdf.rhea-db.org/35048; http://rdf.rhea-db.org/35048 rh:substrates/rh:products""}, {""reference_id"": ""MetaCyc:RXN-8348"", ""source_assertion"": ""RXN-8348 explicitly cross-references RHEA:35048; its native left-to-right reaction is selected."", ""source_locator"": ""/ptools-xml/*[@frameid='RXN-8348']/reaction-direction; dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""MetaCyc:CPD-8123"", ""source_assertion"": ""CPD-8123 links CHEBI:71302 but its native CML represents MoO2-MPT with formula C10H10MoN5O8PS2 and charge -2. The graph uses the current Rhea chemical form instead."", ""source_locator"": ""/ptools-xml/*[@frameid='CPD-8123']/cml/molecule/@formalCharge; cml/molecule/formula; dblink""}]"	"[{""id"": ""MetaCyc:CPD-8123"", ""source_sha256"": ""e15a9085c4a8b37712698e00767a684a35314095010977b6281336e65dd4b3b6"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""CPD-8123"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-8123""}, {""id"": ""MetaCyc:PWY-6823"", ""source_sha256"": ""93a2e4fa02ba082e4094d65e423f3132701a687a6856aa4cf958e685172d477f"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""molybdenum cofactor biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6823""}, {""id"": ""MetaCyc:RXN-8348"", ""source_sha256"": ""225331bf53efc4d1648c0e861f73f75f5cefa10997def6249a39739f6b2db497"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""RXN-8348"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8348""}, {""id"": ""RHEA:35047"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 of the complete compressed RDF distribution"", ""title"": ""Rhea reaction 35047"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-053_37cd8bc9b0e9	UniProtKB:P30745	pathwaymech:enables	RHEA:49577	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:EG11595-MONOMER|MetaCyc:ENZRXN-19108|UniProtKB:P30745	The K-12 MoaA cyclase assignment is inferred by HAMAP. The inspected purified-enzyme cyclase work used Staphylococcus aureus MoaA; E. coli expression hosts do not make those experiments direct evidence for the K-12 enzyme. Current monomer/homodimer annotation does not establish an isolated monomer requirement.	"[{""reference_id"": ""UniProtKB:P30745"", ""source_assertion"": ""P30745 is annotated for RHEA:49576 by ECO:0000255, HAMAP MF_01225."", ""source_locator"": ""$.comments[2].reaction""}, {""reference_id"": ""MetaCyc:EG11595-MONOMER"", ""source_assertion"": ""The E. coli MoaA frame links UniProt P30745 and catalyzes ENZRXN-19108."", ""source_locator"": ""/ptools-xml/*[@frameid='EG11595-MONOMER']/dblink; catalyzes""}, {""reference_id"": ""MetaCyc:ENZRXN-19108"", ""source_assertion"": ""ENZRXN-19108 assigns EG11595-MONOMER to RXN-8340."", ""source_locator"": ""/ptools-xml/*[@frameid='ENZRXN-19108']/enzyme; reaction""}]"	"[{""id"": ""MetaCyc:EG11595-MONOMER"", ""source_sha256"": ""9f6bab09cc79f22370fa88967f85c871dd2def680e5d675f01e0f8954ac9b9f0"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""EG11595-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:EG11595-MONOMER""}, {""id"": ""MetaCyc:ENZRXN-19108"", ""source_sha256"": ""f0e7efd4865d7e4625c42b119c4cd40df743c17f2515d04b82ac4add82147257"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""ENZRXN-19108"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-19108""}, {""id"": ""UniProtKB:P30745"", ""source_sha256"": ""4110615d7d4172284952aa5de98d4cc9a790c5682830a15a013d84fc6d1bc0af"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""GTP 3',8-cyclase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30745.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-054_22683384fa9a	MetaCyc:CPLX-8331	pathwaymech:catalyzes	RHEA:49581	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8331|PMID:25941396|UniProtKB:P0A738	MoaC converts the cyclized GTP intermediate into cPMP. Direct E. coli kinetic, structural and complementation experiments support this distinct second step; anaerobic nitrate respiration was a complementation readout, not a claim that all pathway steps require an anaerobic cell.	"[{""reference_id"": ""MetaCyc:CPLX-8331"", ""source_assertion"": ""The MoaC complex catalyzes RXN-17809."", ""source_locator"": ""/ptools-xml/*[@frameid='CPLX-8331']/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:P0A738"", ""source_assertion"": ""P0A738 is annotated for RHEA:49580 with ECO:0000269 (PMID:25941396), alongside HAMAP ECO:0000255."", ""source_locator"": ""$.comments[1].reaction""}, {""reference_id"": ""PMID:25941396"", ""source_assertion"": ""E. coli MoaC variants were purified and tested with isolated cyclic GTP; wild-type MoaC rescued E. coli delta-moaC under anaerobic nitrate respiration."", ""source_locator"": ""Results; Figure 1E-G; Materials and Methods""}]"	"[{""id"": ""MetaCyc:CPLX-8331"", ""source_sha256"": ""7ff6e3a299e8515a5b20c3ba132b817cf2c9f2ff07da70519075fb1a263d3ff1"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""cyclic pyranopterin monophosphate synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8331""}, {""id"": ""PMID:25941396"", ""source_sha256"": ""6c3bb72b0356d6234da2cdeb14490f54434148b0604c49c8ec3a8dc26385d916"", ""source_version"": ""PMC full article HTML; retrieved 2026-10-11; digest of actual HTML body"", ""title"": ""Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC4443348/""}, {""id"": ""UniProtKB:P0A738"", ""source_sha256"": ""c89d6bae648be74997ada784d6b2d4f483158827fe5ded10f0443520816adac0"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""Cyclic pyranopterin monophosphate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A738.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-055_094dc6a3b5ce	MetaCyc:CPLX0-248	pathwaymech:catalyzes	RHEA:17458	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-248|MetaCyc:RXN0-308|UniProtKB:P0A6B7	IscS mobilizes cysteine sulfur through its own cysteinyl persulfide. This explicit carrier-state reaction is supported by the native reaction; the broader UniProt sulfur-acceptor reaction is not substituted for it.	"[{""reference_id"": ""MetaCyc:CPLX0-248"", ""source_assertion"": ""The IscS complex catalyzes RXN0-308."", ""source_locator"": ""/ptools-xml/*[@frameid='CPLX0-248']/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:P0A6B7"", ""source_assertion"": ""The reviewed IscS function removes sulfur from cysteine to form alanine and delivers sulfur to multiple partners; multiple ECO:0000269 citations support this role."", ""source_locator"": ""$.comments[0].texts""}, {""reference_id"": ""MetaCyc:RXN0-308"", ""source_assertion"": ""RXN0-308 links the cysteine-desulfurase carrier-state reaction to RHEA:17458."", ""source_locator"": ""/ptools-xml/*[@frameid='RXN0-308']/left; right; dblink[dblink-db=\""RHEA\""]""}]"	"[{""id"": ""MetaCyc:CPLX0-248"", ""source_sha256"": ""e8ae4d9a6ee046d433c646e83b317624ea3f4467b5e58f0c844a242129aacf6e"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""cysteine desulfurase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-248""}, {""id"": ""MetaCyc:RXN0-308"", ""source_sha256"": ""b7cfc31659f90f5637ad8ae269cc09868a47e8c7205b2e18398fadaa6331723c"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""RXN0-308"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-308""}, {""id"": ""UniProtKB:P0A6B7"", ""source_sha256"": ""a0d3b03558f20344c51483645cc0686eec98b255dcfe98c218bbb32d698ebc62"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""Cysteine desulfurase IscS"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6B7.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-056_21f17a1fc991	MetaCyc:CPLX0-8164	pathwaymech:catalyzes	RHEA:43617	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8164|UniProtKB:P12282	The MoeB homodimer adenylates the MoaD C terminus. A transient MoeB2-MoaD2 complex forms during activation; this does not assert catalysis without the MoaD substrate or a MoeB-bound sulfur intermediate.	"[{""reference_id"": ""MetaCyc:CPLX0-8164"", ""source_assertion"": ""The MoeB complex catalyzes RXN-11361."", ""source_locator"": ""/ptools-xml/*[@frameid='CPLX0-8164']/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:P12282"", ""source_assertion"": ""P12282 is annotated for MoaD adenylation, RHEA:43616, with ECO:0000269 (PMID:11463785)."", ""source_locator"": ""$.comments[1].reaction""}, {""reference_id"": ""UniProtKB:P12282"", ""source_assertion"": ""MoeB is a homodimer and forms a stable two-MoeB/two-MoaD complex during MoaD adenylation; ECO:0000269 (PMID:11463785)."", ""source_locator"": ""$.comments[4].texts""}]"	"[{""id"": ""MetaCyc:CPLX0-8164"", ""source_sha256"": ""d97e337e390fdeacbc0016d2fac8c223c46094ec0d341f976d06d5d8734a19a3"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""molybdopterin-synthase adenylyltransferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8164""}, {""id"": ""UniProtKB:P12282"", ""source_sha256"": ""06be591cf9b38c6a04b9e6ece19e9b62ec4869708f5eaa00a4fc6fed9066d64c"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""Molybdopterin-synthase adenylyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P12282.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-057_4e6246498dc6	UniProtKB:P0A6B7	pathwaymech:enables	RHEA:48613	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-12473|PMID:19946146	IscS provides sulfur for the net thiocarboxylation of adenylated MoaD in the reconstituted MoeB/MoaD system. The graph retains the generic reductant and does not assert that isolated IscS carries out every elementary step. Alternative cysteine desulfurases can donate sulfur in vitro.	"[{""quote"": ""IscS is the specific cysteine desulfurase transferring the sulfur to the MoaD protein."", ""reference_id"": ""PMID:19946146""}, {""reference_id"": ""MetaCyc:RXN-12473"", ""source_assertion"": ""RXN-12473 consumes a cysteine-desulfurase persulfide and adenylated MoaD and produces thiocarboxylated MoaD."", ""source_locator"": ""/ptools-xml/*[@frameid='RXN-12473']/left; right""}]"	"[{""id"": ""MetaCyc:RXN-12473"", ""source_sha256"": ""527c2ed585f80ca8afaa9fb74905ae0c8396d06eeb0961b1886c3d4b89884a8e"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""RXN-12473"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-12473""}, {""id"": ""PMID:19946146"", ""source_sha256"": ""9f16b2158946f923fc0fc75db922535351058a334ec6601248c295f4d9b7425b"", ""source_version"": ""PMC full article HTML; retrieved 2026-10-11; digest of actual HTML body"", ""title"": ""IscS functions as a primary sulfur-donating enzyme by interacting specifically with MoeB and MoaD in the biosynthesis of molybdopterin in Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2807287/""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-058_864c149ceee7	UniProtKB:P78067	pathwaymech:enables	RHEA:48613	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:G6952-MONOMER|PMID:21856748	YnjE enhanced cPMP-to-MPT production in a defined IscS/MoeB/MoaD-containing reconstitution. This is an enhancing functional role in the net sulfur-transfer process, not proof of YnjE alone catalyzing the whole reaction or being universally required in vivo. No uniform cellular compartment is assigned.	"[{""quote"": ""YnjE was shown to enhance the rate of the conversion of added cyclic pyranopterin monophosphate to MPT."", ""reference_id"": ""PMID:21856748""}, {""reference_id"": ""MetaCyc:G6952-MONOMER"", ""source_assertion"": ""The YnjE frame links UniProt P78067 and its proposed MoaD sulfurtransferase role; primary PMID:21856748 is cited."", ""source_locator"": ""/ptools-xml/*[@frameid='G6952-MONOMER']/dblink; catalyzes; comment""}]"	"[{""id"": ""MetaCyc:G6952-MONOMER"", ""source_sha256"": ""3729db042cd55efe5b90369b96a99f4881d6a9b46d510b1a52c86de99d7bee72"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""G6952-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G6952-MONOMER""}, {""id"": ""PMID:21856748"", ""source_sha256"": ""844c6971552a2528c9f80eb7bee8c3bf7256992ee572077746e504e1f3ac9435"", ""source_version"": ""Europe PMC indexed primary abstract and metadata; retrieved 2026-10-11; not a full-text digest"", ""title"": ""The identification of a novel protein involved in molybdenum cofactor biosynthesis in Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21856748%20AND%20SRC:MED&format=xml&resultType=core""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-059_dd050627346e	UniProtKB:P30748	pathwaymech:enables	MetaCyc:PWY-6823	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P30748	MoaD carries the sulfur incorporated into the pterin and cycles between free, adenylated and thiocarboxylated forms and the MoeB/MoaE assemblies. Whole Rhea carrier classes express these states; the unmodified sequence accession is not itself a chemically specific carrier state.	"[{""reference_id"": ""UniProtKB:P30748"", ""source_assertion"": ""MoaD participates in sulfur transfer from precursor Z to molybdopterin; ECO:0000269 (PMID:17223713)."", ""source_locator"": ""$.comments[0].texts""}, {""reference_id"": ""UniProtKB:P30748"", ""source_assertion"": ""MoaD shuttles between MoaD2-MoaE2 and MoaD2-MoeB2 complexes during catalysis; ECO:0000269 (PMID:11135669 and PMID:12571227)."", ""source_locator"": ""$.comments[2].texts""}]"	"[{""id"": ""UniProtKB:P30748"", ""source_sha256"": ""b49d242ca7e2f40919e9ca801d3e763ef640899d7c25af9b7f2060473fe024b9"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""Molybdopterin synthase sulfur carrier subunit"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30748.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-060_0691faea6d7d	MetaCyc:CPLX0-2502	pathwaymech:catalyzes	RHEA:26334	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-2502|PMID:12571226|UniProtKB:P30749	The MoaD2-MoaE2 synthase incorporates two sulfur atoms into cPMP. The two thiocarboxylated MoaD equivalents are explicit, and the carrier is regenerated for another activation cycle.	"[{""reference_id"": ""MetaCyc:CPLX0-2502"", ""source_assertion"": ""The MoaD/MoaE complex catalyzes RXN-8342."", ""source_locator"": ""/ptools-xml/*[@frameid='CPLX0-2502']/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:P30749"", ""source_assertion"": ""MoaE is annotated for RHEA:26333, consuming two thiocarboxylated MoaD equivalents; ECO:0000269 (PMID:12571226)."", ""source_locator"": ""$.comments[1].reaction""}, {""quote"": ""a dimer of dimers containing the MoaD and MoaE proteins"", ""reference_id"": ""PMID:12571226""}]"	"[{""id"": ""MetaCyc:CPLX0-2502"", ""source_sha256"": ""317ff2de15556b73f985a00f76ad1c3a263c3807f8cf84acce5a190986efe1cb"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""molybdopterin synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-2502""}, {""id"": ""PMID:12571226"", ""source_sha256"": ""aaaa22d59fba194fee4fe08e900022f472955be688f24d803b44063c57e14518"", ""source_version"": ""Europe PMC indexed primary abstract and metadata; retrieved 2026-10-11; not a full-text digest"", ""title"": ""Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12571226%20AND%20SRC:MED&format=xml&resultType=core""}, {""id"": ""UniProtKB:P30749"", ""source_sha256"": ""a31a83eb3fbfb04809577d6de3bf21a60d4d05e0cc20c0ea87c6214a7a9c7e50"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""Molybdopterin synthase catalytic subunit"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30749.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-061_8c14c6956587	MetaCyc:CPLX0-8163	pathwaymech:catalyzes	RHEA:31332	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8163|UniProtKB:P0AF03	Mog adenylates molybdopterin before molybdate insertion. ATP/magnesium assay conditions do not independently establish a separate bound-magnesium cofactor assignment for Mog.	"[{""reference_id"": ""MetaCyc:CPLX0-8163"", ""source_assertion"": ""The Mog complex catalyzes RXN-8344."", ""source_locator"": ""/ptools-xml/*[@frameid='CPLX0-8163']/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:P0AF03"", ""source_assertion"": ""P0AF03 is annotated for RHEA:31331 with ECO:0000269 (PMID:15632135)."", ""source_locator"": ""$.comments[1].reaction""}]"	"[{""id"": ""MetaCyc:CPLX0-8163"", ""source_sha256"": ""2a7ca9881245b7206f71bdb110b66807e06c0488b9b80e66cd6f9cb8dc38ab89"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""molybdopterin adenylyltransferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8163""}, {""id"": ""UniProtKB:P0AF03"", ""source_sha256"": ""b5ba930f3656b6430bb87632bb717446c8ea4701122a4d9778e5b86f0b320823"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""Molybdopterin adenylyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF03.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-062_6e732b6aedca	MetaCyc:CPLX0-8045	pathwaymech:catalyzes	RHEA:35048	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8045|PMID:15632135|UniProtKB:P12281	MoeA inserts molybdate into adenylyl-molybdopterin. The purified E. coli system used human apo-sulfite oxidase as a cofactor readout, not as the E. coli catalyst. This endpoint precedes guanylylation/cytidylylation and downstream cofactor loading.	"[{""reference_id"": ""MetaCyc:CPLX0-8045"", ""source_assertion"": ""The MoeA complex catalyzes RXN-8348."", ""source_locator"": ""/ptools-xml/*[@frameid='CPLX0-8045']/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:P12281"", ""source_assertion"": ""P12281 is annotated for RHEA:35047 with ECO:0000269 (PMID:15632135)."", ""source_locator"": ""$.comments[1].reaction""}, {""quote"": ""Escherichia coli MoeA and MogA are required in vivo for the final step of molybdenum cofactor biosynthesis"", ""reference_id"": ""PMID:15632135""}]"	"[{""id"": ""MetaCyc:CPLX0-8045"", ""source_sha256"": ""ebdb60f4362986ba49f9fddfb25a61e86c0bf454d63f729944e2ed0c7af5b267"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""molybdopterin molybdotransferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8045""}, {""id"": ""PMID:15632135"", ""source_sha256"": ""021e4185f0e09fcc02f5e0cb052c5379a6531b34ba859b35efab0bdda2ece415"", ""source_version"": ""Europe PMC indexed primary abstract and metadata; retrieved 2026-10-11; not a full-text digest"", ""title"": ""In vitro molybdenum ligation to molybdopterin using purified components."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15632135%20AND%20SRC:MED&format=xml&resultType=core""}, {""id"": ""UniProtKB:P12281"", ""source_sha256"": ""acb939ed73d6e19e7f3fd9009704637018bc482b141cfe9cb5ab1330e89dc87d"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""Molybdopterin molybdenumtransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P12281.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-063_1472e190ee31	UniProtKB:P0A738	BFO:0000050	MetaCyc:CPLX-8331	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8331|MetaCyc:EG11666-MONOMER|PMID:25941396|UniProtKB:P0A738	Native assembly stoichiometry: 6 copies of this subunit. The native complex is curated for MG1655, within the selected K-12 scope. Transient catalytic states and alternative partner assemblies are described separately.	"[{""reference_id"": ""MetaCyc:CPLX-8331"", ""source_assertion"": ""CPLX-8331 contains 6 copies of EG11666-MONOMER."", ""source_locator"": ""/ptools-xml/*[@frameid='CPLX-8331']/component[Protein/@frameid=\""EG11666-MONOMER\""]/coefficient""}, {""reference_id"": ""MetaCyc:EG11666-MONOMER"", ""source_assertion"": ""EG11666-MONOMER links the selected E. coli protein to UniProt P0A738."", ""source_locator"": ""/ptools-xml/*[@frameid='EG11666-MONOMER']/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:P0A738"", ""source_assertion"": ""The reviewed SUBUNIT comment supports the 6-copy P0A738 component in this assembly; its cited experimental evidence is retained."", ""source_locator"": ""$.comments[4].texts""}, {""quote"": ""The hexameric structure (a trimer of homodimers)"", ""reference_id"": ""PMID:25941396""}]"	"[{""id"": ""MetaCyc:CPLX-8331"", ""source_sha256"": ""7ff6e3a299e8515a5b20c3ba132b817cf2c9f2ff07da70519075fb1a263d3ff1"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""cyclic pyranopterin monophosphate synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8331""}, {""id"": ""MetaCyc:EG11666-MONOMER"", ""source_sha256"": ""69286a8ba10d3bd007170549310ea27ccdd4ca0d67274700d1471ea5bf2620e2"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""EG11666-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:EG11666-MONOMER""}, {""id"": ""PMID:25941396"", ""source_sha256"": ""6c3bb72b0356d6234da2cdeb14490f54434148b0604c49c8ec3a8dc26385d916"", ""source_version"": ""PMC full article HTML; retrieved 2026-10-11; digest of actual HTML body"", ""title"": ""Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC4443348/""}, {""id"": ""UniProtKB:P0A738"", ""source_sha256"": ""c89d6bae648be74997ada784d6b2d4f483158827fe5ded10f0443520816adac0"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""Cyclic pyranopterin monophosphate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A738.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-064_e25ec978d64c	UniProtKB:P30748	BFO:0000050	MetaCyc:CPLX0-2502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-2502|MetaCyc:EG11597-MONOMER|UniProtKB:P30748	Native assembly stoichiometry: 2 copies of this subunit. The native complex is curated for MG1655, within the selected K-12 scope. Transient catalytic states and alternative partner assemblies are described separately.	"[{""reference_id"": ""MetaCyc:CPLX0-2502"", ""source_assertion"": ""CPLX0-2502 contains 2 copies of EG11597-MONOMER."", ""source_locator"": ""/ptools-xml/*[@frameid='CPLX0-2502']/component[Protein/@frameid=\""EG11597-MONOMER\""]/coefficient""}, {""reference_id"": ""MetaCyc:EG11597-MONOMER"", ""source_assertion"": ""EG11597-MONOMER links the selected E. coli protein to UniProt P30748."", ""source_locator"": ""/ptools-xml/*[@frameid='EG11597-MONOMER']/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:P30748"", ""source_assertion"": ""The reviewed SUBUNIT comment supports the 2-copy P30748 component in this assembly; its cited experimental evidence is retained."", ""source_locator"": ""$.comments[2].texts""}]"	"[{""id"": ""MetaCyc:CPLX0-2502"", ""source_sha256"": ""317ff2de15556b73f985a00f76ad1c3a263c3807f8cf84acce5a190986efe1cb"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""molybdopterin synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-2502""}, {""id"": ""MetaCyc:EG11597-MONOMER"", ""source_sha256"": ""4f082fbab591303702994ac66c1b50387624a89f0998b4c9841e2a465d397d99"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""EG11597-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:EG11597-MONOMER""}, {""id"": ""UniProtKB:P30748"", ""source_sha256"": ""b49d242ca7e2f40919e9ca801d3e763ef640899d7c25af9b7f2060473fe024b9"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""Molybdopterin synthase sulfur carrier subunit"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30748.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-065_cd9bdddf4fc9	UniProtKB:P30749	BFO:0000050	MetaCyc:CPLX0-2502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-2502|MetaCyc:EG11598-MONOMER|UniProtKB:P30749	Native assembly stoichiometry: 2 copies of this subunit. The native complex is curated for MG1655, within the selected K-12 scope. Transient catalytic states and alternative partner assemblies are described separately.	"[{""reference_id"": ""MetaCyc:CPLX0-2502"", ""source_assertion"": ""CPLX0-2502 contains 2 copies of EG11598-MONOMER."", ""source_locator"": ""/ptools-xml/*[@frameid='CPLX0-2502']/component[Protein/@frameid=\""EG11598-MONOMER\""]/coefficient""}, {""reference_id"": ""MetaCyc:EG11598-MONOMER"", ""source_assertion"": ""EG11598-MONOMER links the selected E. coli protein to UniProt P30749."", ""source_locator"": ""/ptools-xml/*[@frameid='EG11598-MONOMER']/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:P30749"", ""source_assertion"": ""The reviewed SUBUNIT comment supports the 2-copy P30749 component in this assembly; its cited experimental evidence is retained."", ""source_locator"": ""$.comments[3].texts""}]"	"[{""id"": ""MetaCyc:CPLX0-2502"", ""source_sha256"": ""317ff2de15556b73f985a00f76ad1c3a263c3807f8cf84acce5a190986efe1cb"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""molybdopterin synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-2502""}, {""id"": ""MetaCyc:EG11598-MONOMER"", ""source_sha256"": ""f308cd2f2f7c5c28e001ff896a6a78651b47819f045eb38885c4af1a4b0b50a8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""EG11598-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:EG11598-MONOMER""}, {""id"": ""UniProtKB:P30749"", ""source_sha256"": ""a31a83eb3fbfb04809577d6de3bf21a60d4d05e0cc20c0ea87c6214a7a9c7e50"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""Molybdopterin synthase catalytic subunit"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30749.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-066_1224d7f032d3	UniProtKB:P12282	BFO:0000050	MetaCyc:CPLX0-8164	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8164|MetaCyc:EG10154-MONOMER|UniProtKB:P12282	Native assembly stoichiometry: 2 copies of this subunit. The native complex is curated for MG1655, within the selected K-12 scope. Transient catalytic states and alternative partner assemblies are described separately.	"[{""reference_id"": ""MetaCyc:CPLX0-8164"", ""source_assertion"": ""CPLX0-8164 contains 2 copies of EG10154-MONOMER."", ""source_locator"": ""/ptools-xml/*[@frameid='CPLX0-8164']/component[Protein/@frameid=\""EG10154-MONOMER\""]/coefficient""}, {""reference_id"": ""MetaCyc:EG10154-MONOMER"", ""source_assertion"": ""EG10154-MONOMER links the selected E. coli protein to UniProt P12282."", ""source_locator"": ""/ptools-xml/*[@frameid='EG10154-MONOMER']/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:P12282"", ""source_assertion"": ""The reviewed SUBUNIT comment supports the 2-copy P12282 component in this assembly; its cited experimental evidence is retained."", ""source_locator"": ""$.comments[4].texts""}]"	"[{""id"": ""MetaCyc:CPLX0-8164"", ""source_sha256"": ""d97e337e390fdeacbc0016d2fac8c223c46094ec0d341f976d06d5d8734a19a3"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""molybdopterin-synthase adenylyltransferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8164""}, {""id"": ""MetaCyc:EG10154-MONOMER"", ""source_sha256"": ""ac7aa43dec44034cc37d2ccf5c533afb7c5c612342dd2ddd7a4eb4a2fbf0617e"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""EG10154-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:EG10154-MONOMER""}, {""id"": ""UniProtKB:P12282"", ""source_sha256"": ""06be591cf9b38c6a04b9e6ece19e9b62ec4869708f5eaa00a4fc6fed9066d64c"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""Molybdopterin-synthase adenylyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P12282.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-067_03e000960536	UniProtKB:P0AF03	BFO:0000050	MetaCyc:CPLX0-8163	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8163|MetaCyc:EG11511-MONOMER|UniProtKB:P0AF03	Native assembly stoichiometry: 3 copies of this subunit. The native complex is curated for MG1655, within the selected K-12 scope. Transient catalytic states and alternative partner assemblies are described separately.	"[{""reference_id"": ""MetaCyc:CPLX0-8163"", ""source_assertion"": ""CPLX0-8163 contains 3 copies of EG11511-MONOMER."", ""source_locator"": ""/ptools-xml/*[@frameid='CPLX0-8163']/component[Protein/@frameid=\""EG11511-MONOMER\""]/coefficient""}, {""reference_id"": ""MetaCyc:EG11511-MONOMER"", ""source_assertion"": ""EG11511-MONOMER links the selected E. coli protein to UniProt P0AF03."", ""source_locator"": ""/ptools-xml/*[@frameid='EG11511-MONOMER']/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:P0AF03"", ""source_assertion"": ""The reviewed SUBUNIT comment supports the 3-copy P0AF03 component in this assembly; its cited experimental evidence is retained."", ""source_locator"": ""$.comments[3].texts""}]"	"[{""id"": ""MetaCyc:CPLX0-8163"", ""source_sha256"": ""2a7ca9881245b7206f71bdb110b66807e06c0488b9b80e66cd6f9cb8dc38ab89"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""molybdopterin adenylyltransferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8163""}, {""id"": ""MetaCyc:EG11511-MONOMER"", ""source_sha256"": ""2754f8d8676ca1c58a726dc4f0810e7a626409ffcdb1fa4364db5c34cb56250e"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""EG11511-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:EG11511-MONOMER""}, {""id"": ""UniProtKB:P0AF03"", ""source_sha256"": ""b5ba930f3656b6430bb87632bb717446c8ea4701122a4d9778e5b86f0b320823"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""Molybdopterin adenylyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF03.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-068_a72387cb0498	UniProtKB:P12281	BFO:0000050	MetaCyc:CPLX0-8045	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8045|MetaCyc:EG10153-MONOMER|UniProtKB:P12281	Native assembly stoichiometry: 2 copies of this subunit. The native complex is curated for MG1655, within the selected K-12 scope. Transient catalytic states and alternative partner assemblies are described separately.	"[{""reference_id"": ""MetaCyc:CPLX0-8045"", ""source_assertion"": ""CPLX0-8045 contains 2 copies of EG10153-MONOMER."", ""source_locator"": ""/ptools-xml/*[@frameid='CPLX0-8045']/component[Protein/@frameid=\""EG10153-MONOMER\""]/coefficient""}, {""reference_id"": ""MetaCyc:EG10153-MONOMER"", ""source_assertion"": ""EG10153-MONOMER links the selected E. coli protein to UniProt P12281."", ""source_locator"": ""/ptools-xml/*[@frameid='EG10153-MONOMER']/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:P12281"", ""source_assertion"": ""The reviewed SUBUNIT comment supports the 2-copy P12281 component in this assembly; its cited experimental evidence is retained."", ""source_locator"": ""$.comments[4].texts""}]"	"[{""id"": ""MetaCyc:CPLX0-8045"", ""source_sha256"": ""ebdb60f4362986ba49f9fddfb25a61e86c0bf454d63f729944e2ed0c7af5b267"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""molybdopterin molybdotransferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8045""}, {""id"": ""MetaCyc:EG10153-MONOMER"", ""source_sha256"": ""64298639fe9abbf522831c9fb3011423878d7e62571f7385cd5824625d6961a5"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""EG10153-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:EG10153-MONOMER""}, {""id"": ""UniProtKB:P12281"", ""source_sha256"": ""acb939ed73d6e19e7f3fd9009704637018bc482b141cfe9cb5ab1330e89dc87d"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""Molybdopterin molybdenumtransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P12281.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-069_dfc3dd3a6636	UniProtKB:P0A6B7	BFO:0000050	MetaCyc:CPLX0-248	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-248|MetaCyc:G7325-MONOMER|UniProtKB:P0A6B7	Native assembly stoichiometry: 2 copies of this subunit. The native complex is curated for MG1655, within the selected K-12 scope. Transient catalytic states and alternative partner assemblies are described separately.	"[{""reference_id"": ""MetaCyc:CPLX0-248"", ""source_assertion"": ""CPLX0-248 contains 2 copies of G7325-MONOMER."", ""source_locator"": ""/ptools-xml/*[@frameid='CPLX0-248']/component[Protein/@frameid=\""G7325-MONOMER\""]/coefficient""}, {""reference_id"": ""MetaCyc:G7325-MONOMER"", ""source_assertion"": ""G7325-MONOMER links the selected E. coli protein to UniProt P0A6B7."", ""source_locator"": ""/ptools-xml/*[@frameid='G7325-MONOMER']/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""UniProtKB:P0A6B7"", ""source_assertion"": ""The reviewed SUBUNIT comment supports the 2-copy P0A6B7 component in this assembly; its cited experimental evidence is retained."", ""source_locator"": ""$.comments[6].texts""}]"	"[{""id"": ""MetaCyc:CPLX0-248"", ""source_sha256"": ""e8ae4d9a6ee046d433c646e83b317624ea3f4467b5e58f0c844a242129aacf6e"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""cysteine desulfurase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-248""}, {""id"": ""MetaCyc:G7325-MONOMER"", ""source_sha256"": ""557d0dc9060ac3d794d97c59d4b91b5cad3845874d9e77f28f714ef87a6266d1"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""G7325-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G7325-MONOMER""}, {""id"": ""UniProtKB:P0A6B7"", ""source_sha256"": ""a0d3b03558f20344c51483645cc0686eec98b255dcfe98c218bbb32d698ebc62"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""Cysteine desulfurase IscS"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6B7.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-070_dadeb31959fd	UniProtKB:P30745	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P30745	Two [4Fe-4S] clusters are inferred for K-12 MoaA by HAMAP. SAM-dependent chemistry and oxygen-sensitive enzyme preparation are distinguished from a blanket anaerobic-growth requirement.	"[{""reference_id"": ""UniProtKB:P30745"", ""source_assertion"": ""The cofactor comment assigns two [4Fe-4S] clusters, CHEBI:49883, with ECO:0000255 (HAMAP MF_01225)."", ""source_locator"": ""$.comments[3].cofactors; $.comments[3].note""}]"	"[{""id"": ""UniProtKB:P30745"", ""source_sha256"": ""4110615d7d4172284952aa5de98d4cc9a790c5682830a15a013d84fc6d1bc0af"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""GTP 3',8-cyclase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30745.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-071_8364f621bcc5	UniProtKB:P12282	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P12282	The reviewed MoeB annotation assigns one zinc ion per subunit. This is distinct from magnesium supplied with ATP in activation assays.	"[{""reference_id"": ""UniProtKB:P12282"", ""source_assertion"": ""The cofactor comment assigns CHEBI:29105, one zinc ion per subunit, with ECO:0000269 (PMID:11463785)."", ""source_locator"": ""$.comments[2].cofactors; $.comments[2].note""}]"	"[{""id"": ""UniProtKB:P12282"", ""source_sha256"": ""06be591cf9b38c6a04b9e6ece19e9b62ec4869708f5eaa00a4fc6fed9066d64c"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""Molybdopterin-synthase adenylyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P12282.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-072_511eda3545e7	UniProtKB:P12281	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P12281	The reviewed MoeA annotation assigns one bound magnesium ion per subunit from structural evidence; it is not inferred merely from MgATP assay conditions.	"[{""reference_id"": ""UniProtKB:P12281"", ""source_assertion"": ""The cofactor comment assigns CHEBI:18420, one magnesium ion per subunit, with ECO:0000269 (PMID:11428898)."", ""source_locator"": ""$.comments[2].cofactors; $.comments[2].note""}]"	"[{""id"": ""UniProtKB:P12281"", ""source_sha256"": ""acb939ed73d6e19e7f3fd9009704637018bc482b141cfe9cb5ab1330e89dc87d"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""Molybdopterin molybdenumtransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P12281.json""}]"	""
pathwaymech:MetaCyc_PWY-6823_moco-edge-073_0b3e3e3482c2	UniProtKB:P0A6B7	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6B7	IscS uses pyridoxal phosphate for cysteine desulfuration.	"[{""reference_id"": ""UniProtKB:P0A6B7"", ""source_assertion"": ""The cofactor comment explicitly identifies CHEBI:597326 with ECO:0000269 (PMID:10600118 and PMID:12860127) and HAMAP ECO:0000255."", ""source_locator"": ""$.comments[2].cofactors""}]"	"[{""id"": ""UniProtKB:P0A6B7"", ""source_sha256"": ""a0d3b03558f20344c51483645cc0686eec98b255dcfe98c218bbb32d698ebc62"", ""source_version"": ""UniProtKB 2026_03; retrieved 2026-10-11"", ""title"": ""Cysteine desulfurase IscS"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6B7.json""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-1_66c368a02abe	CHEBI:58243	pathwaymech:consumes	Reactome:R-MTU-936655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction1 places physical entity SmallMolecule1 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction1/bp:left/#SmallMolecule1; #BiochemicalReaction1/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-2_3f916194811d	Reactome:R-MTU-936674	pathwaymech:consumes	Reactome:R-MTU-936655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction1 places physical entity Protein1 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction1/bp:left/#Protein1; #BiochemicalReaction1/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-3_13bc3f82d346	Reactome:R-MTU-936655	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction1 places physical entity SmallMolecule2 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction1/bp:right/#SmallMolecule2; #BiochemicalReaction1/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-4_aa28f9150149	Reactome:R-MTU-936655	pathwaymech:produces	Reactome:R-MTU-1222293	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction1 places physical entity Protein2 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction1/bp:right/#Protein2; #BiochemicalReaction1/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-5_121d10382dd5	Reactome:R-MTU-936655	pathwaymech:produces	CHEBI:48854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction1 places physical entity SmallMolecule3 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction1/bp:right/#SmallMolecule3; #BiochemicalReaction1/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-6_b52463bbce2e	Reactome:R-MTU-936655	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction1 places physical entity SmallMolecule4 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction1/bp:right/#SmallMolecule4; #BiochemicalReaction1/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-7_982df4f742c3	Reactome:R-MTU-936655	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""All physical entities on both sides of BioPAX BiochemicalReaction1 have the same cellular location."", ""source_locator"": ""#BiochemicalReaction1/bp:left|bp:right; physicalEntity/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-8_23581886da30	CHEBI:15378	pathwaymech:consumes	Reactome:R-MTU-936703	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction2 places physical entity SmallMolecule2 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction2/bp:left/#SmallMolecule2; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-9_ed619cbfcf7c	CHEBI:48854	pathwaymech:consumes	Reactome:R-MTU-936703	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction2 places physical entity SmallMolecule3 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction2/bp:left/#SmallMolecule3; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-10_73cf7902ce54	Reactome:R-MTU-937263	pathwaymech:consumes	Reactome:R-MTU-936703	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction2 places physical entity Complex2 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction2/bp:left/#Complex2; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-11_9941b33d529b	Reactome:R-MTU-936703	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction2 places physical entity SmallMolecule6 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction2/bp:right/#SmallMolecule6; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-12_80010af3f914	Reactome:R-MTU-936703	pathwaymech:produces	CHEBI:15138	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction2 places physical entity SmallMolecule7 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction2/bp:right/#SmallMolecule7; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-13_f995c20a4bb0	Reactome:R-MTU-936703	pathwaymech:produces	Reactome:R-MTU-937267	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction2 places physical entity Complex3 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction2/bp:right/#Complex3; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-14_59a6e64140da	Reactome:R-MTU-936703	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""All physical entities on both sides of BioPAX BiochemicalReaction2 have the same cellular location."", ""source_locator"": ""#BiochemicalReaction2/bp:left|bp:right; physicalEntity/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-15_3ccc837c28f9	CHEBI:57288	pathwaymech:consumes	Reactome:R-MTU-936615	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction3 places physical entity SmallMolecule10 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction3/bp:left/#SmallMolecule10; #BiochemicalReaction3/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-16_11368377693b	CHEBI:33384	pathwaymech:consumes	Reactome:R-MTU-936615	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction3 places physical entity SmallMolecule11 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction3/bp:left/#SmallMolecule11; #BiochemicalReaction3/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-17_912fd860f454	Reactome:R-MTU-936615	pathwaymech:produces	CHEBI:17981	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction3 places physical entity SmallMolecule12 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction3/bp:right/#SmallMolecule12; #BiochemicalReaction3/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-18_5c8a87108fe9	Reactome:R-MTU-936615	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction3 places physical entity SmallMolecule13 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction3/bp:right/#SmallMolecule13; #BiochemicalReaction3/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-19_e56ca009b19c	Reactome:R-MTU-936615	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""All physical entities on both sides of BioPAX BiochemicalReaction3 have the same cellular location."", ""source_locator"": ""#BiochemicalReaction3/bp:left|bp:right; physicalEntity/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-20_add43a1ae6d5	CHEBI:15138	pathwaymech:consumes	Reactome:R-MTU-936642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction4 places physical entity SmallMolecule7 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction4/bp:left/#SmallMolecule7; #BiochemicalReaction4/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-21_111b0ae738e9	CHEBI:17981	pathwaymech:consumes	Reactome:R-MTU-936642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction4 places physical entity SmallMolecule12 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction4/bp:left/#SmallMolecule12; #BiochemicalReaction4/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-22_9d85314882b9	Reactome:R-MTU-936642	pathwaymech:produces	CHEBI:15366	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction4 places physical entity SmallMolecule14 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction4/bp:right/#SmallMolecule14; #BiochemicalReaction4/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-23_d853f3dd7fe3	Reactome:R-MTU-936642	pathwaymech:produces	CHEBI:35235	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX BiochemicalReaction4 places physical entity SmallMolecule15 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction4/bp:right/#SmallMolecule15; #BiochemicalReaction4/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-24_bab8d76b0618	Reactome:R-MTU-936642	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""All physical entities on both sides of BioPAX BiochemicalReaction4 have the same cellular location."", ""source_locator"": ""#BiochemicalReaction4/bp:left|bp:right; physicalEntity/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-30_9954d0cc2598	Reactome:R-MTU-936704	pathwaymech:catalyzes	Reactome:R-MTU-936655	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX Catalysis1 names Complex1 as its catalytic controller."", ""source_locator"": ""#Catalysis1/bp:controller/#Complex1; bp:controlled/#BiochemicalReaction1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-31_af515863c7ca	Reactome:R-MTU-936607	pathwaymech:catalyzes	Reactome:R-MTU-936703	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721	Reactome assigns this Sir holoenzyme to sulfite reduction. PMID17644602 assayed purified M. tuberculosis SirA with methyl viologen; its deletion physiology was in M. smegmatis, not direct validation of this particular ferredoxin pair.	"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX Catalysis2 names Complex4 as its catalytic controller."", ""source_locator"": ""#Catalysis2/bp:controller/#Complex4; bp:controlled/#BiochemicalReaction2""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-32_219f6971a166	Reactome:R-MTU-936604	pathwaymech:catalyzes	Reactome:R-MTU-936615	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:23483228|Reactome:R-MTU-936721	Direct recombinant H37Rv CysE characterization supersedes the source comment that direct biochemical evidence was unavailable.	"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX Catalysis3 names Protein6 as its catalytic controller."", ""source_locator"": ""#Catalysis3/bp:controller/#Protein6; bp:controlled/#BiochemicalReaction3""}, {""quote"": ""The serine acetyltransferase activity of M. tuberculosis CysE protein was detected."", ""reference_id"": ""PMID:23483228""}]"	"[{""id"": ""PMID:23483228"", ""source_sha256"": ""97e00c0aec96dd72808582420e5c68f8227c47df88a94564291c901f5bc74c02"", ""title"": ""Identification and characterization of serine acetyltransferase encoded by the Mycobacterium tuberculosis Rv2335 gene"", ""url"": ""https://www.spandidos-publications.com/10.3892/ijmm.2013.1298?text=fulltext""}, {""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-33_8158ed45eb70	Reactome:R-MTU-936755	pathwaymech:catalyzes	Reactome:R-MTU-936642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX Catalysis4 names Complex5 as its catalytic controller."", ""source_locator"": ""#Catalysis4/bp:controller/#Complex5; bp:controlled/#BiochemicalReaction4""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-35_f088c7f67665	CHEBI:15138	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity SmallMolecule7 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule7/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-36_4e84c7d38928	CHEBI:15377	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity SmallMolecule6 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule6/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-37_894d1ac54a73	CHEBI:456215	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity SmallMolecule4 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule4/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-38_cd01ed569e6d	CHEBI:48854	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity SmallMolecule3 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule3/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-39_fe8bb5c04807	CHEBI:15378	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity SmallMolecule2 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule2/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-40_320cf9833931	CHEBI:35235	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity SmallMolecule15 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule15/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-41_3fa5592773c2	CHEBI:15366	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity SmallMolecule14 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule14/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-42_36f0eed9e0fb	CHEBI:57287	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity SmallMolecule13 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule13/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-43_cb071fff3c49	CHEBI:17981	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity SmallMolecule12 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule12/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-44_b156480a4265	CHEBI:33384	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity SmallMolecule11 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule11/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-45_c7ca7c7597af	CHEBI:57288	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity SmallMolecule10 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule10/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-46_8bdd7fb3e496	CHEBI:58243	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity SmallMolecule1 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule1/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-48_2c1bf125fff9	Reactome:R-MTU-936604	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity Protein6 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Protein6/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-49_5027869d9120	Reactome:R-MTU-1222293	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity Protein2 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Protein2/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-50_c2f13dbbf2b0	Reactome:R-MTU-936674	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity Protein1 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Protein1/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-51_480f32934c1a	Reactome:R-MTU-936755	BFO:0000051	Reactome:R-MTU-936587	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX complex Complex5 explicitly includes physical entity Protein7."", ""source_locator"": ""#Complex5/bp:component/#Protein7""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-52_2e864d29eaa5	Reactome:R-MTU-936755	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity Complex5 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Complex5/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-53_f646fccbe9b3	Reactome:R-MTU-936587	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity Protein7 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Protein7/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-54_823ebbd51e82	Reactome:R-MTU-936607	BFO:0000051	CHEBI:28599	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX complex Complex4 explicitly includes physical entity SmallMolecule9."", ""source_locator"": ""#Complex4/bp:component/#SmallMolecule9""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-55_f7e6bc88e77f	Reactome:R-MTU-936607	BFO:0000051	Reactome:R-ALL-70986	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX complex Complex4 explicitly includes physical entity PhysicalEntity1."", ""source_locator"": ""#Complex4/bp:component/#PhysicalEntity1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-56_711cea36f0fa	Reactome:R-MTU-936607	BFO:0000051	Reactome:R-MTU-936705	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX complex Complex4 explicitly includes physical entity Protein5."", ""source_locator"": ""#Complex4/bp:component/#Protein5""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-57_37a6cdf0fad7	Reactome:R-MTU-936607	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity Complex4 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Complex4/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-58_61f4e3b08689	Reactome:R-MTU-936705	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity Protein5 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Protein5/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-59_609738204f18	Reactome:R-ALL-70986	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity PhysicalEntity1 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#PhysicalEntity1/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-60_bfa5e09f0fb5	CHEBI:28599	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity SmallMolecule9 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule9/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-61_56ebf875fd3d	Reactome:R-MTU-937267	BFO:0000051	Reactome:R-MTU-937262	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX complex Complex3 explicitly includes physical entity Protein4."", ""source_locator"": ""#Complex3/bp:component/#Protein4""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-62_2d5d06a21206	Reactome:R-MTU-937267	BFO:0000051	CHEBI:33722	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721|UniProtKB:P9WNE7	Retained as partial source composition, without the source cluster stoichiometry. UniProt P9WNE7 annotates one [4Fe-4S] and one [3Fe-4S] cluster by similarity; this edge does not assert complete composition.	"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX complex Complex3 explicitly includes physical entity SmallMolecule8."", ""source_locator"": ""#Complex3/bp:component/#SmallMolecule8""}, {""reference_id"": ""UniProtKB:P9WNE7"", ""source_assertion"": ""The COFACTOR annotations list one [4Fe-4S] and one [3Fe-4S] cluster, each with ECO:0000250 similarity evidence. They do not establish the charge of each cluster in this native source state."", ""source_locator"": ""$.results[12].comments[1:3]""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}, {""id"": ""UniProtKB:P9WNE7"", ""source_sha256"": ""9d5fc21a10f70ef21cf95ffb126f8e850f11441b59f377c0311d11cd3012ab54"", ""source_version"": ""retrieved 2026-10-07; release not exposed"", ""title"": ""UniProtKB P9WNE7 ferredoxin cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=accession%3AP71745+OR+accession%3AP71746+OR+accession%3AP95231+OR+accession%3AP9WHS1+OR+accession%3AP9WIK1+OR+accession%3AP9WIK3+OR+accession%3AP9WJ03+OR+accession%3AP9WKJ1+OR+accession%3AP9WMN7+OR+accession%3AP9WNE7+OR+accession%3AP9WNM5+OR+accession%3AP9WP53+OR+accession%3AP9WP55+OR+accession%3AP9WQM1+OR+accession%3AQ79FV4&format=json&size=500""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-64_639d1c55b3e9	Reactome:R-MTU-937267	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity Complex3 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Complex3/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-65_9e9b3bab4b59	CHEBI:33723	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity SmallMolecule5 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule5/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-66_fd4dccb56def	CHEBI:33722	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity SmallMolecule8 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule8/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-67_e0f82e6d5b74	Reactome:R-MTU-937262	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity Protein4 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Protein4/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-68_a79529820ae6	Reactome:R-MTU-937263	BFO:0000051	Reactome:R-MTU-937262	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX complex Complex2 explicitly includes physical entity Protein4."", ""source_locator"": ""#Complex2/bp:component/#Protein4""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-69_d0f2a38f9572	Reactome:R-MTU-937263	BFO:0000051	CHEBI:33723	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721|UniProtKB:P9WNE7	Retained as partial source composition, without the source cluster stoichiometry. UniProt P9WNE7 annotates one [4Fe-4S] and one [3Fe-4S] cluster by similarity; this edge does not assert complete composition.	"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX complex Complex2 explicitly includes physical entity SmallMolecule5."", ""source_locator"": ""#Complex2/bp:component/#SmallMolecule5""}, {""reference_id"": ""UniProtKB:P9WNE7"", ""source_assertion"": ""The COFACTOR annotations list one [4Fe-4S] and one [3Fe-4S] cluster, each with ECO:0000250 similarity evidence. They do not establish the charge of each cluster in this native source state."", ""source_locator"": ""$.results[12].comments[1:3]""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}, {""id"": ""UniProtKB:P9WNE7"", ""source_sha256"": ""9d5fc21a10f70ef21cf95ffb126f8e850f11441b59f377c0311d11cd3012ab54"", ""source_version"": ""retrieved 2026-10-07; release not exposed"", ""title"": ""UniProtKB P9WNE7 ferredoxin cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=accession%3AP71745+OR+accession%3AP71746+OR+accession%3AP95231+OR+accession%3AP9WHS1+OR+accession%3AP9WIK1+OR+accession%3AP9WIK3+OR+accession%3AP9WJ03+OR+accession%3AP9WKJ1+OR+accession%3AP9WMN7+OR+accession%3AP9WNE7+OR+accession%3AP9WNM5+OR+accession%3AP9WP53+OR+accession%3AP9WP55+OR+accession%3AP9WQM1+OR+accession%3AQ79FV4&format=json&size=500""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-70_e39c267008be	Reactome:R-MTU-937263	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity Complex2 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Complex2/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-71_262d20cb834b	Reactome:R-MTU-936704	BFO:0000051	Reactome:R-ALL-70986	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX complex Complex1 explicitly includes physical entity PhysicalEntity1."", ""source_locator"": ""#Complex1/bp:component/#PhysicalEntity1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-72_d2306f7fdf4d	Reactome:R-MTU-936704	BFO:0000051	Reactome:R-MTU-936694	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX complex Complex1 explicitly includes physical entity Protein3."", ""source_locator"": ""#Complex1/bp:component/#Protein3""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-73_fdfaf65f116e	Reactome:R-MTU-936704	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity Complex1 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Complex1/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_biopax-edge-74_34b100745eeb	Reactome:R-MTU-936694	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721		"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX physical entity Protein3 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Protein3/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_curated-flow-1_e11578dbc6e4	Reactome:R-MTU-936655	RO:0002413	Reactome:R-MTU-936703	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721	Source-ordered material transfer through CHEBI:48854; no regulatory sign or stoichiometric coefficient is asserted.	"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX PathwayStep1 explicitly lists PathwayStep2 as nextStep; the linked reactions produce and consume the same source physical entity."", ""source_locator"": ""#PathwayStep1/bp:nextStep/#PathwayStep2; #BiochemicalReaction1/bp:right/#SmallMolecule3; #BiochemicalReaction1/bp:conversionDirection; #BiochemicalReaction2/bp:left/#SmallMolecule3; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_curated-flow-2_dac55782489c	Reactome:R-MTU-936703	RO:0002413	Reactome:R-MTU-936642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721	Source-ordered material transfer through CHEBI:15138; no regulatory sign or stoichiometric coefficient is asserted.	"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX PathwayStep2 explicitly lists PathwayStep4 as nextStep; the linked reactions produce and consume the same source physical entity."", ""source_locator"": ""#PathwayStep2/bp:nextStep/#PathwayStep4; #BiochemicalReaction2/bp:right/#SmallMolecule7; #BiochemicalReaction2/bp:conversionDirection; #BiochemicalReaction4/bp:left/#SmallMolecule7; #BiochemicalReaction4/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936721_curated-flow-3_feced6b71119	Reactome:R-MTU-936615	RO:0002413	Reactome:R-MTU-936642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936721	Source-ordered material transfer through CHEBI:17981; no regulatory sign or stoichiometric coefficient is asserted.	"[{""reference_id"": ""Reactome:R-MTU-936721"", ""source_assertion"": ""BioPAX PathwayStep3 explicitly lists PathwayStep4 as nextStep; the linked reactions produce and consume the same source physical entity."", ""source_locator"": ""#PathwayStep3/bp:nextStep/#PathwayStep4; #BiochemicalReaction3/bp:right/#SmallMolecule12; #BiochemicalReaction3/bp:conversionDirection; #BiochemicalReaction4/bp:left/#SmallMolecule12; #BiochemicalReaction4/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936721"", ""source_sha256"": ""810756282671ad39c8be2ddf04e500fb53b33fe6a5f5ad51ecb955b263efe5e4"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936721"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936721""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-5_896216f8e9ea	Reactome:R-MTU-936718	pathwaymech:consumes	Reactome:R-MTU-936665	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX BiochemicalReaction2 places physical entity Protein2 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction2/bp:left/#Protein2; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-6_b94facd47a05	CHEBI:57524	pathwaymech:consumes	Reactome:R-MTU-936665	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX BiochemicalReaction2 places physical entity SmallMolecule2 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction2/bp:left/#SmallMolecule2; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-7_d62d33cff1a8	Reactome:R-MTU-936665	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX BiochemicalReaction2 places physical entity SmallMolecule3 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction2/bp:right/#SmallMolecule3; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-8_b18e9e4e9d75	Reactome:R-MTU-936665	pathwaymech:produces	Reactome:R-MTU-936690	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX BiochemicalReaction2 places physical entity Protein4 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction2/bp:right/#Protein4; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-9_b73cd51ecae9	Reactome:R-MTU-936665	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""All physical entities on both sides of BioPAX BiochemicalReaction2 have the same cellular location."", ""source_locator"": ""#BiochemicalReaction2/bp:left|bp:right; physicalEntity/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-10_649c68c783bd	CHEBI:15377	pathwaymech:consumes	Reactome:R-MTU-936747	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX BiochemicalReaction3 places physical entity SmallMolecule4 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction3/bp:left/#SmallMolecule4; #BiochemicalReaction3/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-11_9676be1a1be3	Reactome:R-MTU-936690	pathwaymech:consumes	Reactome:R-MTU-936747	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX BiochemicalReaction3 places physical entity Protein4 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction3/bp:left/#Protein4; #BiochemicalReaction3/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-12_050beefdc99c	Reactome:R-MTU-936747	pathwaymech:produces	Reactome:R-MTU-936619	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX BiochemicalReaction3 places physical entity Protein1 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction3/bp:right/#Protein1; #BiochemicalReaction3/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-13_0cfcfbbde759	Reactome:R-MTU-936747	pathwaymech:produces	CHEBI:35235	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX BiochemicalReaction3 places physical entity SmallMolecule5 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction3/bp:right/#SmallMolecule5; #BiochemicalReaction3/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-14_d01b05dc3b5c	Reactome:R-MTU-936747	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""All physical entities on both sides of BioPAX BiochemicalReaction3 have the same cellular location."", ""source_locator"": ""#BiochemicalReaction3/bp:left|bp:right; physicalEntity/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-16_ab0371249e4e	Reactome:R-MTU-936569	pathwaymech:catalyzes	Reactome:R-MTU-936665	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX Catalysis2 names Complex1 as its catalytic controller."", ""source_locator"": ""#Catalysis2/bp:controller/#Complex1; bp:controlled/#BiochemicalReaction2""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-17_39967adb40aa	Reactome:R-MTU-936637	pathwaymech:catalyzes	Reactome:R-MTU-936747	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX Catalysis3 names Complex2 as its catalytic controller."", ""source_locator"": ""#Catalysis3/bp:controller/#Complex2; bp:controlled/#BiochemicalReaction3""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-18_68d0bc2abca7	CHEBI:35235	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX physical entity SmallMolecule5 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule5/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-19_942bbde1d221	CHEBI:15377	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX physical entity SmallMolecule4 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule4/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-20_e33103db7af7	CHEBI:43474	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX physical entity SmallMolecule3 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule3/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-21_41be0a0f30b5	CHEBI:57524	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX physical entity SmallMolecule2 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule2/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-23_f4007061cea3	Reactome:R-MTU-936690	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX physical entity Protein4 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Protein4/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-25_69e67f5af7e3	Reactome:R-MTU-936718	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX physical entity Protein2 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Protein2/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-26_d6dccf9fd822	Reactome:R-MTU-936619	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX physical entity Protein1 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Protein1/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-27_52d655c942ad	Reactome:R-MTU-936637	BFO:0000051	Reactome:R-MTU-936660	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX complex Complex2 explicitly includes physical entity Protein6."", ""source_locator"": ""#Complex2/bp:component/#Protein6""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-28_44d59110b794	Reactome:R-MTU-936637	BFO:0000051	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX complex Complex2 explicitly includes physical entity SmallMolecule6."", ""source_locator"": ""#Complex2/bp:component/#SmallMolecule6""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-29_7709655dab48	Reactome:R-MTU-936637	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX physical entity Complex2 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Complex2/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-30_d3defa66914a	CHEBI:29105	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX physical entity SmallMolecule6 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#SmallMolecule6/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-31_0ff0508d0d8f	Reactome:R-MTU-936660	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX physical entity Protein6 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Protein6/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-32_88357e64074f	Reactome:R-MTU-936569	BFO:0000051	Reactome:R-MTU-936710	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX complex Complex1 explicitly includes physical entity Protein5."", ""source_locator"": ""#Complex1/bp:component/#Protein5""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-33_620dfa50cf9f	Reactome:R-MTU-936569	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX physical entity Complex1 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Complex1/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_biopax-edge-34_7afa2a1e6f72	Reactome:R-MTU-936710	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654		"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX physical entity Protein5 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Protein5/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936654_curated-flow-1_4f5d038957d3	Reactome:R-MTU-936665	RO:0002413	Reactome:R-MTU-936747	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936654	Source-ordered material transfer through Reactome:R-MTU-936690; no regulatory sign or stoichiometric coefficient is asserted.	"[{""reference_id"": ""Reactome:R-MTU-936654"", ""source_assertion"": ""BioPAX PathwayStep2 explicitly lists PathwayStep3 as nextStep; the linked reactions produce and consume the same source physical entity."", ""source_locator"": ""#PathwayStep2/bp:nextStep/#PathwayStep3; #BiochemicalReaction2/bp:right/#Protein4; #BiochemicalReaction2/bp:conversionDirection; #BiochemicalReaction3/bp:left/#Protein4; #BiochemicalReaction3/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936654"", ""source_sha256"": ""81265e1ab996bdf4c4126a380f285189dd7cd41e6e68e228fa56d2d09c40ff56"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936654"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936654""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-1_b5969129e908	Reactome:R-MTU-936726	pathwaymech:consumes	Reactome:R-MTU-936667	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction1 places physical entity Protein1 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction1/bp:left/#Protein1; #BiochemicalReaction1/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-2_7941070b85f7	Reactome:R-ALL-427648	pathwaymech:consumes	Reactome:R-MTU-936667	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction1 places physical entity SmallMolecule1 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction1/bp:left/#SmallMolecule1; #BiochemicalReaction1/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-3_4f8511b0e490	Reactome:R-MTU-936667	pathwaymech:produces	Reactome:R-MTU-936589	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction1 places physical entity Complex1 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction1/bp:right/#Complex1; #BiochemicalReaction1/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-4_e15643b3afa4	CHEBI:30616	pathwaymech:consumes	Reactome:R-MTU-936631	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction2 places physical entity SmallMolecule2 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction2/bp:left/#SmallMolecule2; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-5_95514723ed26	CHEBI:15377	pathwaymech:consumes	Reactome:R-MTU-936631	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction2 places physical entity SmallMolecule3 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction2/bp:left/#SmallMolecule3; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-6_dd080bd80b13	Reactome:R-MTU-936589	pathwaymech:consumes	Reactome:R-MTU-936631	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction2 places physical entity Complex1 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction2/bp:left/#Complex1; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-7_64f676c887d2	Reactome:R-MTU-936631	pathwaymech:produces	Reactome:R-MTU-936726	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction2 places physical entity Protein1 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction2/bp:right/#Protein1; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-8_e31b979e4195	Reactome:R-MTU-936631	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction2 places physical entity SmallMolecule4 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction2/bp:right/#SmallMolecule4; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-9_0c5b5ffaa219	Reactome:R-MTU-936631	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction2 places physical entity SmallMolecule5 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction2/bp:right/#SmallMolecule5; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-10_ff69c26db4f3	Reactome:R-MTU-936631	pathwaymech:produces	Reactome:R-ALL-174375	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction2 places physical entity SmallMolecule6 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction2/bp:right/#SmallMolecule6; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-11_ed21772d008e	CHEBI:30616	pathwaymech:consumes	Reactome:R-MTU-936729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction3 places physical entity SmallMolecule2 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction3/bp:left/#SmallMolecule2; #BiochemicalReaction3/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-12_c7552246f957	Reactome:R-ALL-174375	pathwaymech:consumes	Reactome:R-MTU-936729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction3 places physical entity SmallMolecule6 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction3/bp:left/#SmallMolecule6; #BiochemicalReaction3/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-13_c3a0cf8f048e	Reactome:R-MTU-936729	pathwaymech:produces	CHEBI:58243	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction3 places physical entity SmallMolecule7 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction3/bp:right/#SmallMolecule7; #BiochemicalReaction3/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-14_dcd349216db0	Reactome:R-MTU-936729	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction3 places physical entity SmallMolecule8 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction3/bp:right/#SmallMolecule8; #BiochemicalReaction3/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-15_b35465151423	Reactome:R-MTU-936729	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""All physical entities on both sides of BioPAX BiochemicalReaction3 have the same cellular location."", ""source_locator"": ""#BiochemicalReaction3/bp:left|bp:right; physicalEntity/bp:cellularLocation/#CellularLocationVocabulary3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-16_ad652c716642	CHEBI:30616	pathwaymech:consumes	Reactome:R-MTU-936583	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction4 places physical entity SmallMolecule2 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction4/bp:left/#SmallMolecule2; #BiochemicalReaction4/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-17_97b3da21396b	CHEBI:58243	pathwaymech:consumes	Reactome:R-MTU-936583	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction4 places physical entity SmallMolecule7 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction4/bp:left/#SmallMolecule7; #BiochemicalReaction4/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-18_704d2d80a72f	CHEBI:15377	pathwaymech:consumes	Reactome:R-MTU-936729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WNM5	Corrected placement of the GTP-hydrolysis component from APS kinase to the coupled APS-synthesis event. This qualitative edge does not specify a stoichiometric coefficient.	"[{""reference_id"": ""UniProtKB:P9WNM5"", ""source_assertion"": ""The structured FUNCTION annotation couples CysN GTP hydrolysis to CysD-mediated APS synthesis (ECO:0000250). This edge assigns the reactant CHEBI:15377 of that hydrolysis component to the APS-synthesis event."", ""source_locator"": ""$.results[5].comments[0].texts[0]""}]"	"[{""id"": ""UniProtKB:P9WNM5"", ""source_sha256"": ""9d5fc21a10f70ef21cf95ffb126f8e850f11441b59f377c0311d11cd3012ab54"", ""source_version"": ""retrieved 2026-10-07; release not exposed"", ""title"": ""UniProtKB P9WNM5 bifunctional CysNC function and catalytic-activity annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=accession%3AP71745+OR+accession%3AP71746+OR+accession%3AP95231+OR+accession%3AP9WHS1+OR+accession%3AP9WIK1+OR+accession%3AP9WIK3+OR+accession%3AP9WJ03+OR+accession%3AP9WKJ1+OR+accession%3AP9WMN7+OR+accession%3AP9WNE7+OR+accession%3AP9WNM5+OR+accession%3AP9WP53+OR+accession%3AP9WP55+OR+accession%3AP9WQM1+OR+accession%3AQ79FV4&format=json&size=500""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-19_ab9a8dba0409	CHEBI:37565	pathwaymech:consumes	Reactome:R-MTU-936729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:15615729|UniProtKB:P9WNM5	Corrected placement of the GTP-hydrolysis component from APS kinase to the coupled APS-synthesis event. This qualitative edge does not specify a stoichiometric coefficient.	"[{""reference_id"": ""UniProtKB:P9WNM5"", ""source_assertion"": ""The structured FUNCTION annotation couples CysN GTP hydrolysis to CysD-mediated APS synthesis (ECO:0000250). This edge assigns the reactant CHEBI:37565 of that hydrolysis component to the APS-synthesis event."", ""source_locator"": ""$.results[5].comments[0].texts[0]""}, {""quote"": ""The stoichiometry of GTP hydrolysis and APS synthesis is 1:1"", ""reference_id"": ""PMID:15615729""}]"	"[{""id"": ""PMID:15615729"", ""title"": ""The trifunctional sulfate-activating complex (SAC) of Mycobacterium tuberculosis""}, {""id"": ""UniProtKB:P9WNM5"", ""source_sha256"": ""9d5fc21a10f70ef21cf95ffb126f8e850f11441b59f377c0311d11cd3012ab54"", ""source_version"": ""retrieved 2026-10-07; release not exposed"", ""title"": ""UniProtKB P9WNM5 bifunctional CysNC function and catalytic-activity annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=accession%3AP71745+OR+accession%3AP71746+OR+accession%3AP95231+OR+accession%3AP9WHS1+OR+accession%3AP9WIK1+OR+accession%3AP9WIK3+OR+accession%3AP9WJ03+OR+accession%3AP9WKJ1+OR+accession%3AP9WMN7+OR+accession%3AP9WNE7+OR+accession%3AP9WNM5+OR+accession%3AP9WP53+OR+accession%3AP9WP55+OR+accession%3AP9WQM1+OR+accession%3AQ79FV4&format=json&size=500""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-20_a41a99364393	Reactome:R-MTU-936583	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction4 places physical entity SmallMolecule4 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction4/bp:right/#SmallMolecule4; #BiochemicalReaction4/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-21_d9bc6cab0b14	Reactome:R-MTU-936583	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WNM5	Qualitative hydron product supported by the APS kinase reaction. Reactome source multiplicity of two is not retained. APS-synthesis proton consumption and coupled GTP-hydrolysis proton production are netted; this graph has no explicit stoichiometric model.	"[{""reference_id"": ""UniProtKB:P9WNM5"", ""source_assertion"": ""The CATALYTIC ACTIVITY reaction for EC:2.7.1.25 lists APS and ATP as reactants and PAPS, ADP and H(+) as products (RHEA:24152)."", ""source_locator"": ""$.results[5].comments[3].reaction""}]"	"[{""id"": ""UniProtKB:P9WNM5"", ""source_sha256"": ""9d5fc21a10f70ef21cf95ffb126f8e850f11441b59f377c0311d11cd3012ab54"", ""source_version"": ""retrieved 2026-10-07; release not exposed"", ""title"": ""UniProtKB P9WNM5 bifunctional CysNC function and catalytic-activity annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=accession%3AP71745+OR+accession%3AP71746+OR+accession%3AP95231+OR+accession%3AP9WHS1+OR+accession%3AP9WIK1+OR+accession%3AP9WIK3+OR+accession%3AP9WJ03+OR+accession%3AP9WKJ1+OR+accession%3AP9WMN7+OR+accession%3AP9WNE7+OR+accession%3AP9WNM5+OR+accession%3AP9WP53+OR+accession%3AP9WP55+OR+accession%3AP9WQM1+OR+accession%3AQ79FV4&format=json&size=500""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-22_87b2497756ad	Reactome:R-MTU-936729	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WNM5	Corrected placement of the GTP-hydrolysis component from APS kinase to the coupled APS-synthesis event. This qualitative edge does not specify a stoichiometric coefficient.	"[{""reference_id"": ""UniProtKB:P9WNM5"", ""source_assertion"": ""The structured FUNCTION annotation couples CysN GTP hydrolysis to CysD-mediated APS synthesis (ECO:0000250). This edge assigns the product CHEBI:43474 of that hydrolysis component to the APS-synthesis event."", ""source_locator"": ""$.results[5].comments[0].texts[0]""}]"	"[{""id"": ""UniProtKB:P9WNM5"", ""source_sha256"": ""9d5fc21a10f70ef21cf95ffb126f8e850f11441b59f377c0311d11cd3012ab54"", ""source_version"": ""retrieved 2026-10-07; release not exposed"", ""title"": ""UniProtKB P9WNM5 bifunctional CysNC function and catalytic-activity annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=accession%3AP71745+OR+accession%3AP71746+OR+accession%3AP95231+OR+accession%3AP9WHS1+OR+accession%3AP9WIK1+OR+accession%3AP9WIK3+OR+accession%3AP9WJ03+OR+accession%3AP9WKJ1+OR+accession%3AP9WMN7+OR+accession%3AP9WNE7+OR+accession%3AP9WNM5+OR+accession%3AP9WP53+OR+accession%3AP9WP55+OR+accession%3AP9WQM1+OR+accession%3AQ79FV4&format=json&size=500""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-23_d2d76b409b2f	Reactome:R-MTU-936583	pathwaymech:produces	CHEBI:58339	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction4 places physical entity SmallMolecule11 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction4/bp:right/#SmallMolecule11; #BiochemicalReaction4/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-24_cec4f0b72350	Reactome:R-MTU-936729	pathwaymech:produces	CHEBI:58189	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WNM5	Corrected placement of the GTP-hydrolysis component from APS kinase to the coupled APS-synthesis event. This qualitative edge does not specify a stoichiometric coefficient.	"[{""reference_id"": ""UniProtKB:P9WNM5"", ""source_assertion"": ""The structured FUNCTION annotation couples CysN GTP hydrolysis to CysD-mediated APS synthesis (ECO:0000250). This edge assigns the product CHEBI:58189 of that hydrolysis component to the APS-synthesis event."", ""source_locator"": ""$.results[5].comments[0].texts[0]""}]"	"[{""id"": ""UniProtKB:P9WNM5"", ""source_sha256"": ""9d5fc21a10f70ef21cf95ffb126f8e850f11441b59f377c0311d11cd3012ab54"", ""source_version"": ""retrieved 2026-10-07; release not exposed"", ""title"": ""UniProtKB P9WNM5 bifunctional CysNC function and catalytic-activity annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=accession%3AP71745+OR+accession%3AP71746+OR+accession%3AP95231+OR+accession%3AP9WHS1+OR+accession%3AP9WIK1+OR+accession%3AP9WIK3+OR+accession%3AP9WJ03+OR+accession%3AP9WKJ1+OR+accession%3AP9WMN7+OR+accession%3AP9WNE7+OR+accession%3AP9WNM5+OR+accession%3AP9WP53+OR+accession%3AP9WP55+OR+accession%3AP9WQM1+OR+accession%3AQ79FV4&format=json&size=500""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-25_644e5ad41d9a	Reactome:R-MTU-936583	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""All physical entities on both sides of BioPAX BiochemicalReaction4 have the same cellular location."", ""source_locator"": ""#BiochemicalReaction4/bp:left|bp:right; physicalEntity/bp:cellularLocation/#CellularLocationVocabulary3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-26_864278c39390	CHEBI:15377	pathwaymech:consumes	Reactome:R-MTU-936659	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction5 places physical entity SmallMolecule3 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction5/bp:left/#SmallMolecule3; #BiochemicalReaction5/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-27_775b143f6a57	CHEBI:58339	pathwaymech:consumes	Reactome:R-MTU-936659	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction5 places physical entity SmallMolecule11 on its left side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction5/bp:left/#SmallMolecule11; #BiochemicalReaction5/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-28_d0637f7a7dbd	Reactome:R-MTU-936659	pathwaymech:produces	CHEBI:58243	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction5 places physical entity SmallMolecule7 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction5/bp:right/#SmallMolecule7; #BiochemicalReaction5/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-29_eccb1c371d73	Reactome:R-MTU-936659	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX BiochemicalReaction5 places physical entity SmallMolecule5 on its right side; conversion direction is LEFT-TO-RIGHT; displayed orientation is LEFT-TO-RIGHT."", ""source_locator"": ""#BiochemicalReaction5/bp:right/#SmallMolecule5; #BiochemicalReaction5/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-30_e76d699ee022	Reactome:R-MTU-936659	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""All physical entities on both sides of BioPAX BiochemicalReaction5 have the same cellular location."", ""source_locator"": ""#BiochemicalReaction5/bp:left|bp:right; physicalEntity/bp:cellularLocation/#CellularLocationVocabulary3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-31_e344219f66fe	Reactome:R-MTU-936707	pathwaymech:catalyzes	Reactome:R-MTU-936631	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX Catalysis1 names Complex2 as its catalytic controller."", ""source_locator"": ""#Catalysis1/bp:controller/#Complex2; bp:controlled/#BiochemicalReaction2""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-32_ceadc5aa3770	Reactome:R-MTU-936606	pathwaymech:catalyzes	Reactome:R-MTU-936729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX Catalysis2 names Complex3 as its catalytic controller."", ""source_locator"": ""#Catalysis2/bp:controller/#Complex3; bp:controlled/#BiochemicalReaction3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-33_b92e24c431c8	Reactome:R-MTU-936606	pathwaymech:catalyzes	Reactome:R-MTU-936583	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX Catalysis3 names Complex3 as its catalytic controller."", ""source_locator"": ""#Catalysis3/bp:controller/#Complex3; bp:controlled/#BiochemicalReaction4""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-34_5c302d74b7a7	Reactome:R-MTU-936691	pathwaymech:catalyzes	Reactome:R-MTU-936659	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635	Source CysQ PAPS hydrolysis assignment has qualitative biochemical support (PMID18454554). PAP, not PAPS, was quantitatively characterized; membrane localization and oligomer context are retained as Reactome assertions.	"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX Catalysis4 names Complex4 as its catalytic controller."", ""source_locator"": ""#Catalysis4/bp:controller/#Complex4; bp:controlled/#BiochemicalReaction5""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-35_f1dd2d550115	CHEBI:37565	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity SmallMolecule9 is assigned to cellular location CellularLocationVocabulary3."", ""source_locator"": ""#SmallMolecule9/bp:cellularLocation/#CellularLocationVocabulary3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-36_62f25a1e9f6a	CHEBI:33019	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity SmallMolecule8 is assigned to cellular location CellularLocationVocabulary3."", ""source_locator"": ""#SmallMolecule8/bp:cellularLocation/#CellularLocationVocabulary3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-37_a34f3dcc18ef	CHEBI:58243	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity SmallMolecule7 is assigned to cellular location CellularLocationVocabulary3."", ""source_locator"": ""#SmallMolecule7/bp:cellularLocation/#CellularLocationVocabulary3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-38_360e404a6287	Reactome:R-ALL-174375	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity SmallMolecule6 is assigned to cellular location CellularLocationVocabulary3."", ""source_locator"": ""#SmallMolecule6/bp:cellularLocation/#CellularLocationVocabulary3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-39_367858bec301	CHEBI:43474	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity SmallMolecule5 is assigned to cellular location CellularLocationVocabulary3."", ""source_locator"": ""#SmallMolecule5/bp:cellularLocation/#CellularLocationVocabulary3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-40_1ce3412af2f1	CHEBI:456216	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity SmallMolecule4 is assigned to cellular location CellularLocationVocabulary3."", ""source_locator"": ""#SmallMolecule4/bp:cellularLocation/#CellularLocationVocabulary3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-41_40f9cfd7f105	CHEBI:15377	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity SmallMolecule3 is assigned to cellular location CellularLocationVocabulary3."", ""source_locator"": ""#SmallMolecule3/bp:cellularLocation/#CellularLocationVocabulary3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-42_96a13a87d73d	CHEBI:30616	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity SmallMolecule2 is assigned to cellular location CellularLocationVocabulary3."", ""source_locator"": ""#SmallMolecule2/bp:cellularLocation/#CellularLocationVocabulary3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-43_5a4736747bd1	CHEBI:58189	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity SmallMolecule12 is assigned to cellular location CellularLocationVocabulary3."", ""source_locator"": ""#SmallMolecule12/bp:cellularLocation/#CellularLocationVocabulary3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-44_b45dfc5db471	CHEBI:58339	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity SmallMolecule11 is assigned to cellular location CellularLocationVocabulary3."", ""source_locator"": ""#SmallMolecule11/bp:cellularLocation/#CellularLocationVocabulary3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-45_11a31e71b124	CHEBI:15378	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity SmallMolecule10 is assigned to cellular location CellularLocationVocabulary3."", ""source_locator"": ""#SmallMolecule10/bp:cellularLocation/#CellularLocationVocabulary3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-46_0dfd218e4f70	Reactome:R-ALL-427648	RO:0001025	GO:0005576	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity SmallMolecule1 is assigned to cellular location CellularLocationVocabulary2."", ""source_locator"": ""#SmallMolecule1/bp:cellularLocation/#CellularLocationVocabulary2""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-47_b172bcd78266	Reactome:R-MTU-936726	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity Protein1 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Protein1/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-48_4409687c773b	Reactome:R-MTU-936691	BFO:0000051	Reactome:R-MTU-936671	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX complex Complex4 explicitly includes physical entity Complex5."", ""source_locator"": ""#Complex4/bp:component/#Complex5""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-49_90695d848bca	Reactome:R-MTU-936691	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity Complex4 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Complex4/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-50_74db84e47ab5	Reactome:R-MTU-936671	BFO:0000051	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX complex Complex5 explicitly includes physical entity SmallMolecule13."", ""source_locator"": ""#Complex5/bp:component/#SmallMolecule13""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-51_d95709280cbd	Reactome:R-MTU-936671	BFO:0000051	Reactome:R-MTU-936577	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX complex Complex5 explicitly includes physical entity Protein7."", ""source_locator"": ""#Complex5/bp:component/#Protein7""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-52_27f23ab8f996	Reactome:R-MTU-936671	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity Complex5 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Complex5/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-53_43f4be0f3e9c	Reactome:R-MTU-936577	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity Protein7 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Protein7/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-54_475db6642a04	CHEBI:18420	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity SmallMolecule13 is assigned to cellular location CellularLocationVocabulary3."", ""source_locator"": ""#SmallMolecule13/bp:cellularLocation/#CellularLocationVocabulary3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-55_dca9de81d3ca	Reactome:R-MTU-936606	BFO:0000051	Reactome:R-MTU-936597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX complex Complex3 explicitly includes physical entity Protein5."", ""source_locator"": ""#Complex3/bp:component/#Protein5""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-56_290e56f2d5bf	Reactome:R-MTU-936606	BFO:0000051	Reactome:R-MTU-936698	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX complex Complex3 explicitly includes physical entity Protein6."", ""source_locator"": ""#Complex3/bp:component/#Protein6""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-57_168cd27ee385	Reactome:R-MTU-936606	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity Complex3 is assigned to cellular location CellularLocationVocabulary3."", ""source_locator"": ""#Complex3/bp:cellularLocation/#CellularLocationVocabulary3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-58_e5fab2783dd3	Reactome:R-MTU-936698	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity Protein6 is assigned to cellular location CellularLocationVocabulary3."", ""source_locator"": ""#Protein6/bp:cellularLocation/#CellularLocationVocabulary3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-59_29af6d7c4828	Reactome:R-MTU-936597	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity Protein5 is assigned to cellular location CellularLocationVocabulary3."", ""source_locator"": ""#Protein5/bp:cellularLocation/#CellularLocationVocabulary3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-60_10ffd7fd744e	Reactome:R-MTU-936707	BFO:0000051	Reactome:R-MTU-936743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX complex Complex2 explicitly includes physical entity Protein2."", ""source_locator"": ""#Complex2/bp:component/#Protein2""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-61_be179d682334	Reactome:R-MTU-936707	BFO:0000051	Reactome:R-MTU-936656	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX complex Complex2 explicitly includes physical entity Protein3."", ""source_locator"": ""#Complex2/bp:component/#Protein3""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-62_0d7586c69639	Reactome:R-MTU-936707	BFO:0000051	Reactome:R-MTU-936681	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX complex Complex2 explicitly includes physical entity Protein4."", ""source_locator"": ""#Complex2/bp:component/#Protein4""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-63_311afeb8d3ce	Reactome:R-MTU-936707	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity Complex2 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Complex2/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-64_0b8966d12011	Reactome:R-MTU-936681	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity Protein4 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Protein4/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-65_18b9bc78ce18	Reactome:R-MTU-936656	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity Protein3 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Protein3/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-66_e12c66adbae0	Reactome:R-MTU-936743	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity Protein2 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Protein2/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-67_651bb6429aa7	Reactome:R-MTU-936589	BFO:0000051	Reactome:R-MTU-936726	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX complex Complex1 explicitly includes physical entity Protein1."", ""source_locator"": ""#Complex1/bp:component/#Protein1""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-68_8179ed155a43	Reactome:R-MTU-936589	BFO:0000051	Reactome:R-ALL-427648	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX complex Complex1 explicitly includes physical entity SmallMolecule1."", ""source_locator"": ""#Complex1/bp:component/#SmallMolecule1""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_biopax-edge-69_8e65d1ca6d0b	Reactome:R-MTU-936589	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635		"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX physical entity Complex1 is assigned to cellular location CellularLocationVocabulary1."", ""source_locator"": ""#Complex1/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_curated-flow-1_60458b37f531	Reactome:R-MTU-936667	RO:0002413	Reactome:R-MTU-936631	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635	Source-ordered material transfer through Reactome:R-MTU-936589; no regulatory sign or stoichiometric coefficient is asserted.	"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX PathwayStep1 explicitly lists PathwayStep2 as nextStep; the linked reactions produce and consume the same source physical entity."", ""source_locator"": ""#PathwayStep1/bp:nextStep/#PathwayStep2; #BiochemicalReaction1/bp:right/#Complex1; #BiochemicalReaction1/bp:conversionDirection; #BiochemicalReaction2/bp:left/#Complex1; #BiochemicalReaction2/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_curated-flow-2_a369c1562911	Reactome:R-MTU-936631	RO:0002413	Reactome:R-MTU-936729	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635	Source-ordered material transfer through Reactome:R-ALL-174375; no regulatory sign or stoichiometric coefficient is asserted.	"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX PathwayStep2 explicitly lists PathwayStep3 as nextStep; the linked reactions produce and consume the same source physical entity."", ""source_locator"": ""#PathwayStep2/bp:nextStep/#PathwayStep3; #BiochemicalReaction2/bp:right/#SmallMolecule6; #BiochemicalReaction2/bp:conversionDirection; #BiochemicalReaction3/bp:left/#SmallMolecule6; #BiochemicalReaction3/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-936635_curated-flow-3_a4b91cfa0461	Reactome:R-MTU-936729	RO:0002413	Reactome:R-MTU-936583	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-936635	Source-ordered material transfer through CHEBI:58243; no regulatory sign or stoichiometric coefficient is asserted.	"[{""reference_id"": ""Reactome:R-MTU-936635"", ""source_assertion"": ""BioPAX PathwayStep3 explicitly lists PathwayStep4 as nextStep; the linked reactions produce and consume the same source physical entity."", ""source_locator"": ""#PathwayStep3/bp:nextStep/#PathwayStep4; #BiochemicalReaction3/bp:right/#SmallMolecule7; #BiochemicalReaction3/bp:conversionDirection; #BiochemicalReaction4/bp:left/#SmallMolecule7; #BiochemicalReaction4/bp:conversionDirection""}]"	"[{""id"": ""Reactome:R-MTU-936635"", ""source_sha256"": ""3064b8669aaddd154b89541727131af9f24bdc1980c9bc737c3e56d4533d0b71"", ""source_version"": ""Reactome release 97"", ""title"": ""BioPAX source pathway Reactome:R-MTU-936635"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/936635""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-1_8f21bfa0f389	CHEBI:58885	pathwaymech:consumes	Reactome:R-MTU-868622	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX BiochemicalReaction1 lists UDP-Glc on its left side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction1/bp:left/#SmallMolecule1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-2_b6c7d9f995c9	CHEBI:58225	pathwaymech:consumes	Reactome:R-MTU-868622	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX BiochemicalReaction1 lists G6P on its left side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction1/bp:left/#SmallMolecule2""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-3_536a115b1cf2	Reactome:R-MTU-868622	pathwaymech:produces	CHEBI:18283	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX BiochemicalReaction1 lists αα-T6P on its right side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction1/bp:right/#SmallMolecule3""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-4_1fe68bf25094	Reactome:R-MTU-868622	pathwaymech:produces	CHEBI:58223	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX BiochemicalReaction1 lists UDP on its right side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction1/bp:right/#SmallMolecule4""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-5_b41bd09ac6cc	Reactome:R-MTU-868622	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX BiochemicalReaction1 lists H+ on its right side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction1/bp:right/#SmallMolecule5""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-6_b5f63fbb0e30	Reactome:R-MTU-868622	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""The physical participants of BioPAX BiochemicalReaction1 are assigned to the cytosol."", ""source_locator"": ""#BiochemicalReaction1; participating physicalEntity/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-7_34864ae44a1d	CHEBI:18283	pathwaymech:consumes	Reactome:R-MTU-868608	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX BiochemicalReaction2 lists αα-T6P on its left side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction2/bp:left/#SmallMolecule3""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-8_d73a713cc31b	CHEBI:15377	pathwaymech:consumes	Reactome:R-MTU-868608	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX BiochemicalReaction2 lists H2O on its left side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction2/bp:left/#SmallMolecule6""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-9_cb14b79af4ca	Reactome:R-MTU-868608	pathwaymech:produces	CHEBI:16551	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX BiochemicalReaction2 lists alpha,alpha-trehalose on its right side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction2/bp:right/#SmallMolecule7""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-10_01cd51f17569	Reactome:R-MTU-868608	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX BiochemicalReaction2 lists Pi on its right side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction2/bp:right/#SmallMolecule8""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-11_b9fdf4477273	Reactome:R-MTU-868608	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""The physical participants of BioPAX BiochemicalReaction2 are assigned to the cytosol."", ""source_locator"": ""#BiochemicalReaction2; participating physicalEntity/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-12_00840c5d52f0	Reactome:R-MTU-868709	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""The physical participants of BioPAX BiochemicalReaction3 are assigned to the cytosol."", ""source_locator"": ""#BiochemicalReaction3; participating physicalEntity/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-13_ef9f05ba3b86	CHEBI:15444	pathwaymech:consumes	Reactome:R-MTU-868658	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX BiochemicalReaction4 lists (1,4-alpha-glycosyl)n on its left side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction4/bp:left/#SmallMolecule11""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-14_8ac0b3fab583	Reactome:R-MTU-868658	pathwaymech:produces	CHEBI:134401	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX BiochemicalReaction4 lists glucanotrehalose on its right side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction4/bp:right/#SmallMolecule12""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-15_6f5fcc8ba1c7	Reactome:R-MTU-868658	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""The physical participants of BioPAX BiochemicalReaction4 are assigned to the cytosol."", ""source_locator"": ""#BiochemicalReaction4; participating physicalEntity/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-16_3520b595a3b0	CHEBI:134401	pathwaymech:consumes	Reactome:R-MTU-868657	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX BiochemicalReaction5 lists glucanotrehalose on its left side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction5/bp:left/#SmallMolecule12""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-17_3b0a0fae9f59	CHEBI:15377	pathwaymech:consumes	Reactome:R-MTU-868657	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX BiochemicalReaction5 lists H2O on its left side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction5/bp:left/#SmallMolecule6""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-18_d76e1acf634f	Reactome:R-MTU-868657	pathwaymech:produces	CHEBI:15444	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX BiochemicalReaction5 lists (1->4)-alpha-D-glucan on its right side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction5/bp:right/#SmallMolecule13""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-19_cf0b95bcd261	Reactome:R-MTU-868657	pathwaymech:produces	CHEBI:16551	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX BiochemicalReaction5 lists alpha,alpha-trehalose on its right side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction5/bp:right/#SmallMolecule7""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-20_f140371500b7	Reactome:R-MTU-868657	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""The physical participants of BioPAX BiochemicalReaction5 are assigned to the cytosol."", ""source_locator"": ""#BiochemicalReaction5; participating physicalEntity/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-21_3d8db8583c2d	Reactome:R-MTU-868690	pathwaymech:catalyzes	Reactome:R-MTU-868622	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX Catalysis1 identifies OtsA tetramer as the controller of BiochemicalReaction1."", ""source_locator"": ""#Catalysis1/bp:controller/#Complex1; bp:controlled/#BiochemicalReaction1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-22_ae53a67103a6	Reactome:R-MTU-868623	pathwaymech:catalyzes	Reactome:R-MTU-868608	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX Catalysis2 identifies OtsB-Mg2+ as the controller of BiochemicalReaction2."", ""source_locator"": ""#Catalysis2/bp:controller/#Complex2; bp:controlled/#BiochemicalReaction2""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-23_220bbcdfa4a6	UniProtKB:P9WQ19	pathwaymech:catalyzes	Reactome:R-MTU-868709	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX Catalysis3 identifies TreS as the controller of BiochemicalReaction3."", ""source_locator"": ""#Catalysis3/bp:controller/#Protein3; bp:controlled/#BiochemicalReaction3""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-24_30da311e2c21	UniProtKB:P9WQ21	pathwaymech:catalyzes	Reactome:R-MTU-868658	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX Catalysis4 identifies TreY as the controller of BiochemicalReaction4."", ""source_locator"": ""#Catalysis4/bp:controller/#Protein4; bp:controlled/#BiochemicalReaction4""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-25_7ec4c63e2076	UniProtKB:P9WQ23	pathwaymech:catalyzes	Reactome:R-MTU-868657	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX Catalysis5 identifies TreZ as the controller of BiochemicalReaction5."", ""source_locator"": ""#Catalysis5/bp:controller/#Protein5; bp:controlled/#BiochemicalReaction5""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-26_80ef0fb3e63c	CHEBI:58885	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX SmallMolecule1 assigns UDP-Glc to the cytosol."", ""source_locator"": ""#SmallMolecule1/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-27_43bd8f330010	CHEBI:58225	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX SmallMolecule2 assigns G6P to the cytosol."", ""source_locator"": ""#SmallMolecule2/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-28_8b2b42099d97	CHEBI:18283	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX SmallMolecule3 assigns αα-T6P to the cytosol."", ""source_locator"": ""#SmallMolecule3/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-29_37d96557cb16	CHEBI:58223	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX SmallMolecule4 assigns UDP to the cytosol."", ""source_locator"": ""#SmallMolecule4/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-30_983c9c5b0fba	CHEBI:15378	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX SmallMolecule5 assigns H+ to the cytosol."", ""source_locator"": ""#SmallMolecule5/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-31_f916864fcedb	CHEBI:15377	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX SmallMolecule6 assigns H2O to the cytosol."", ""source_locator"": ""#SmallMolecule6/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-32_d2233b50bce6	CHEBI:16551	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX SmallMolecule7 assigns alpha,alpha-trehalose to the cytosol."", ""source_locator"": ""#SmallMolecule7/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-33_81f7316746e1	CHEBI:43474	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX SmallMolecule8 assigns Pi to the cytosol."", ""source_locator"": ""#SmallMolecule8/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-34_620cbbb8e63b	CHEBI:18420	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX SmallMolecule9 assigns Mg2+ to the cytosol."", ""source_locator"": ""#SmallMolecule9/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-35_9113759a77e4	CHEBI:15444	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX SmallMolecule11 assigns (1,4-alpha-glycosyl)n to the cytosol."", ""source_locator"": ""#SmallMolecule11/bp:cellularLocation/#CellularLocationVocabulary1""}, {""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX SmallMolecule13 assigns (1->4)-alpha-D-glucan to the cytosol."", ""source_locator"": ""#SmallMolecule13/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-36_01dba92a0eae	CHEBI:134401	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX SmallMolecule12 assigns glucanotrehalose to the cytosol."", ""source_locator"": ""#SmallMolecule12/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-37_4474336ce2bf	UniProtKB:P9WN11	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX Protein1 assigns OtsA to the cytosol."", ""source_locator"": ""#Protein1/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-38_a204d9591b52	UniProtKB:P9WFZ5	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX Protein2 assigns OtsB to the cytosol."", ""source_locator"": ""#Protein2/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-39_b6fc21a09f4c	UniProtKB:P9WQ19	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX Protein3 assigns TreS to the cytosol."", ""source_locator"": ""#Protein3/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-40_2fdf15c060a9	UniProtKB:P9WQ21	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX Protein4 assigns TreY to the cytosol."", ""source_locator"": ""#Protein4/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-41_b9e7844c3401	UniProtKB:P9WQ23	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX Protein5 assigns TreZ to the cytosol."", ""source_locator"": ""#Protein5/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-42_397d7dda355e	Reactome:R-MTU-868690	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX Complex1 assigns OtsA tetramer to the cytosol."", ""source_locator"": ""#Complex1/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-43_5f896bf5f5be	Reactome:R-MTU-868690	BFO:0000051	UniProtKB:P9WN11	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX Complex1 includes OtsA as a component of OtsA tetramer."", ""source_locator"": ""#Complex1/bp:component/#Protein1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-44_5251dffad462	Reactome:R-MTU-868623	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX Complex2 assigns OtsB-Mg2+ to the cytosol."", ""source_locator"": ""#Complex2/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-45_72a1f2cc8f14	Reactome:R-MTU-868623	BFO:0000051	UniProtKB:P9WFZ5	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX Complex2 includes OtsB as a component of OtsB-Mg2+."", ""source_locator"": ""#Complex2/bp:component/#Protein2""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-46_34d99b5ea7cd	Reactome:R-MTU-868623	BFO:0000051	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-868688		"[{""reference_id"": ""Reactome:R-MTU-868688"", ""source_assertion"": ""BioPAX Complex2 includes Mg2+ as a component of OtsB-Mg2+."", ""source_locator"": ""#Complex2/bp:component/#SmallMolecule9""}]"	"[{""id"": ""Reactome:R-MTU-868688"", ""source_sha256"": ""f758c6c82c2f242dbfd90bb477f90bc722d1ee99537d26666b5a67d9ac9252fc"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-868688 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/868688""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-47_8535fba92cba	CHEBI:16551	pathwaymech:consumes	Reactome:R-MTU-868709	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:23601637	Physiological direction differs from the older maltose-to-trehalose Reactome diagram.	"[{""reference_id"": ""PMID:23601637"", ""source_assertion"": ""Genetic and NMR experiments support mycobacterial TreS flux from trehalose to alpha-maltose; the biochemical reaction is reversible."", ""source_locator"": ""Results: TreS reaction products and physiological direction; Figure 3""}]"	"[{""id"": ""PMID:23601637"", ""title"": ""Flux through Trehalose Synthase Flows from Trehalose to the Alpha Anomer of Maltose in Mycobacteria"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3918855/""}]"	""
pathwaymech:Reactome_R-MTU-868688_causal-review-48_ccd953a53b58	Reactome:R-MTU-868709	pathwaymech:produces	CHEBI:18167	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:23601637	Physiological direction differs from the older maltose-to-trehalose Reactome diagram.	"[{""reference_id"": ""PMID:23601637"", ""source_assertion"": ""Genetic and NMR experiments support mycobacterial TreS flux from trehalose to alpha-maltose; the biochemical reaction is reversible."", ""source_locator"": ""Results: TreS reaction products and physiological direction; Figure 3""}]"	"[{""id"": ""PMID:23601637"", ""title"": ""Flux through Trehalose Synthase Flows from Trehalose to the Alpha Anomer of Maltose in Mycobacteria"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3918855/""}]"	""
pathwaymech:Reactome_R-MTU-868688_cofactor-e3a2ca822621_79e0d0216e3b	UniProtKB:P9WFZ5	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WFZ5	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:15158675); ECO:0000269 (PubMed:15703182)	"[{""reference_id"": ""UniProtKB:P9WFZ5"", ""source_assertion"": ""UniProtKB:P9WFZ5 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/30/comments/0/cofactors/0""}]"	"[{""id"": ""UniProtKB:P9WFZ5"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P9WFZ5 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:Reactome_R-MTU-868688_cofactor-8dcf4bdfdcc7_3cf60b0572bd	UniProtKB:P9WFZ5	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WFZ5	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:15158675); ECO:0000269 (PubMed:15703182)	"[{""reference_id"": ""UniProtKB:P9WFZ5"", ""source_assertion"": ""UniProtKB:P9WFZ5 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/30/comments/0/cofactors/1""}]"	"[{""id"": ""UniProtKB:P9WFZ5"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P9WFZ5 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-1_85d82e7195d4	Reactome:R-MTU-879331	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""The physical participants of BioPAX BiochemicalReaction1 are assigned to the cytosol."", ""source_locator"": ""#BiochemicalReaction1; participating physicalEntity/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-2_4d08093e5067	Reactome:R-MTU-879298	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""The physical participants of BioPAX BiochemicalReaction2 are assigned to the cytosol."", ""source_locator"": ""#BiochemicalReaction2; participating physicalEntity/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-3_4abefc1a37a6	CHEBI:58892	pathwaymech:consumes	Reactome:R-MTU-879274	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299	Chemical form reconciled with the curated MshA/MshB/MshC reaction definitions; native BioPAX topology retained.	"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX BiochemicalReaction3 lists GlcNAc-Ins-P on its left side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction3/bp:left/#SmallMolecule5""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-4_9a6d3ef0cac5	CHEBI:15377	pathwaymech:consumes	Reactome:R-MTU-879274	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX BiochemicalReaction3 lists H2O on its left side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction3/bp:left/#SmallMolecule7""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-5_89623419fbc6	Reactome:R-MTU-879274	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX BiochemicalReaction3 lists Pi on its right side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction3/bp:right/#SmallMolecule8""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-6_96c73daf3ad1	Reactome:R-MTU-879274	pathwaymech:produces	CHEBI:52442	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX BiochemicalReaction3 lists GlcNAc-Ins on its right side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction3/bp:right/#SmallMolecule9""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-7_95fdad8758fe	Reactome:R-MTU-879274	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""The physical participants of BioPAX BiochemicalReaction3 are assigned to the cytosol."", ""source_locator"": ""#BiochemicalReaction3; participating physicalEntity/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-8_345bc97a942e	CHEBI:15377	pathwaymech:consumes	Reactome:R-MTU-879327	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX BiochemicalReaction4 lists H2O on its left side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction4/bp:left/#SmallMolecule7""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-9_d14c5423315e	CHEBI:52442	pathwaymech:consumes	Reactome:R-MTU-879327	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX BiochemicalReaction4 lists GlcNAc-Ins on its left side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction4/bp:left/#SmallMolecule9""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-10_1d835ddeb5aa	Reactome:R-MTU-879327	pathwaymech:produces	CHEBI:58886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299	Chemical form reconciled with the curated MshA/MshB/MshC reaction definitions; native BioPAX topology retained.	"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX BiochemicalReaction4 lists GlcNI on its right side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction4/bp:right/#SmallMolecule10""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-11_8e7aa9808c7f	Reactome:R-MTU-879327	pathwaymech:produces	CHEBI:30089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299	Chemical form reconciled with the curated MshA/MshB/MshC reaction definitions; native BioPAX topology retained.	"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX BiochemicalReaction4 lists CH3COO- on its right side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction4/bp:right/#SmallMolecule11""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-12_3b2663e641d1	Reactome:R-MTU-879327	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""The physical participants of BioPAX BiochemicalReaction4 are assigned to the cytosol."", ""source_locator"": ""#BiochemicalReaction4; participating physicalEntity/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-13_0e5eba8089a9	Reactome:R-MTU-879319	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""The physical participants of BioPAX BiochemicalReaction5 are assigned to the cytosol."", ""source_locator"": ""#BiochemicalReaction5; participating physicalEntity/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-14_6751038b7661	Reactome:R-MTU-879248	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""The physical participants of BioPAX BiochemicalReaction6 are assigned to the cytosol."", ""source_locator"": ""#BiochemicalReaction6; participating physicalEntity/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-15_61c5583aee1e	Reactome:R-MTU-879258	pathwaymech:catalyzes	Reactome:R-MTU-879331	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Catalysis1 identifies Ino1-Zn2+ as the controller of BiochemicalReaction1."", ""source_locator"": ""#Catalysis1/bp:controller/#Complex1; bp:controlled/#BiochemicalReaction1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-16_baf9d2066753	UniProtKB:P9WMY7	pathwaymech:catalyzes	Reactome:R-MTU-879298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Catalysis2 identifies MshA as the controller of BiochemicalReaction2."", ""source_locator"": ""#Catalysis2/bp:controller/#Protein2; bp:controlled/#BiochemicalReaction2""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-17_ab73770fa357	Reactome:R-MTU-879260	pathwaymech:catalyzes	Reactome:R-MTU-879327	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299	The native zinc-bound Mca assembly represents the aerobic purified form; Fe2+ is favored under physiological anaerobic conditions (PMID:26044118).	"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Catalysis4 identifies mca:Zn2+ as the controller of BiochemicalReaction4."", ""source_locator"": ""#Catalysis4/bp:controller/#Complex2; bp:controlled/#BiochemicalReaction4""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-18_5f2916c21afa	Reactome:R-MTU-879241	pathwaymech:catalyzes	Reactome:R-MTU-879319	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Catalysis5 identifies MshC-Zn2+ as the controller of BiochemicalReaction5."", ""source_locator"": ""#Catalysis5/bp:controller/#Complex3; bp:controlled/#BiochemicalReaction5""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-19_abd02e0fcbf8	UniProtKB:P9WJM7	pathwaymech:catalyzes	Reactome:R-MTU-879248	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Catalysis6 identifies MshD as the controller of BiochemicalReaction6."", ""source_locator"": ""#Catalysis6/bp:controller/#Protein6; bp:controlled/#BiochemicalReaction6""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-20_318f410f12c0	CHEBI:29105	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX SmallMolecule3 assigns Zn2+ to the cytosol."", ""source_locator"": ""#SmallMolecule3/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-21_7fceb55c74a2	CHEBI:57705	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX SmallMolecule4 assigns UDP-GlcNAc to the cytosol."", ""source_locator"": ""#SmallMolecule4/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-22_99364f8f5a14	CHEBI:58892	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299	Chemical form reconciled with the curated MshA/MshB/MshC reaction definitions; native BioPAX topology retained.	"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX SmallMolecule5 assigns GlcNAc-Ins-P to the cytosol."", ""source_locator"": ""#SmallMolecule5/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-23_dcd0a1e2a25c	CHEBI:58223	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX SmallMolecule6 assigns UDP to the cytosol."", ""source_locator"": ""#SmallMolecule6/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-24_dcebab66ab9d	CHEBI:15377	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX SmallMolecule7 assigns H2O to the cytosol."", ""source_locator"": ""#SmallMolecule7/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-25_99488749bc67	CHEBI:43474	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX SmallMolecule8 assigns Pi to the cytosol."", ""source_locator"": ""#SmallMolecule8/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-26_1a61247bbed8	CHEBI:52442	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX SmallMolecule9 assigns GlcNAc-Ins to the cytosol."", ""source_locator"": ""#SmallMolecule9/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-27_ed70add70cf9	CHEBI:58886	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299	Chemical form reconciled with the curated MshA/MshB/MshC reaction definitions; native BioPAX topology retained.	"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX SmallMolecule10 assigns GlcNI to the cytosol."", ""source_locator"": ""#SmallMolecule10/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-28_4afd0a66cf56	CHEBI:30089	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299	Chemical form reconciled with the curated MshA/MshB/MshC reaction definitions; native BioPAX topology retained.	"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX SmallMolecule11 assigns CH3COO- to the cytosol."", ""source_locator"": ""#SmallMolecule11/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-29_db2c00df62bb	CHEBI:35235	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX SmallMolecule12 assigns L-Cys to the cytosol."", ""source_locator"": ""#SmallMolecule12/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-30_758f10325b99	CHEBI:30616	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX SmallMolecule13 assigns ATP to the cytosol."", ""source_locator"": ""#SmallMolecule13/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-31_336fdfeece5c	CHEBI:456215	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX SmallMolecule14 assigns AMP to the cytosol."", ""source_locator"": ""#SmallMolecule14/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-32_e467e1736c8b	CHEBI:33019	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX SmallMolecule16 assigns PPi to the cytosol."", ""source_locator"": ""#SmallMolecule16/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-33_6bb631d70521	CHEBI:57288	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX SmallMolecule17 assigns Ac-CoA to the cytosol."", ""source_locator"": ""#SmallMolecule17/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-34_155d58beccfc	CHEBI:57287	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX SmallMolecule18 assigns CoA-SH to the cytosol."", ""source_locator"": ""#SmallMolecule18/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-35_9f0bc12eab0d	CHEBI:16768	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX SmallMolecule19 assigns MSH to the cytosol."", ""source_locator"": ""#SmallMolecule19/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-36_75bd0f21d832	UniProtKB:P9WKI1	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Protein1 assigns Ino1 to the cytosol."", ""source_locator"": ""#Protein1/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-37_7b0d939e195b	UniProtKB:P9WMY7	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Protein2 assigns MshA to the cytosol."", ""source_locator"": ""#Protein2/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-38_d0cd35a8ee30	UniProtKB:P9WJN1	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Protein4 assigns mca to the cytosol."", ""source_locator"": ""#Protein4/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-39_1ab77d4508e4	UniProtKB:P9WJM9	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Protein5 assigns MshC to the cytosol."", ""source_locator"": ""#Protein5/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-40_a594be1e841d	UniProtKB:P9WJM7	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Protein6 assigns MshD to the cytosol."", ""source_locator"": ""#Protein6/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-41_1a24aa0429fc	Reactome:R-MTU-879258	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Complex1 assigns Ino1-Zn2+ to the cytosol."", ""source_locator"": ""#Complex1/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-42_3dc3dab7b176	Reactome:R-MTU-879258	BFO:0000051	UniProtKB:P9WKI1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Complex1 includes Ino1 as a component of Ino1-Zn2+."", ""source_locator"": ""#Complex1/bp:component/#Protein1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-43_545be3f9dd8c	Reactome:R-MTU-879258	BFO:0000051	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Complex1 includes Zn2+ as a component of Ino1-Zn2+."", ""source_locator"": ""#Complex1/bp:component/#SmallMolecule3""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-44_b18e6815081d	Reactome:R-MTU-879260	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Complex2 assigns mca:Zn2+ to the cytosol."", ""source_locator"": ""#Complex2/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-45_25ed55eea98c	Reactome:R-MTU-879260	BFO:0000051	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Complex2 includes Zn2+ as a component of mca:Zn2+."", ""source_locator"": ""#Complex2/bp:component/#SmallMolecule3""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-46_6227d6c1c67b	Reactome:R-MTU-879260	BFO:0000051	UniProtKB:P9WJN1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Complex2 includes mca as a component of mca:Zn2+."", ""source_locator"": ""#Complex2/bp:component/#Protein4""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-47_728731ef5477	Reactome:R-MTU-879241	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Complex3 assigns MshC-Zn2+ to the cytosol."", ""source_locator"": ""#Complex3/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-48_47bb21da18df	Reactome:R-MTU-879241	BFO:0000051	UniProtKB:P9WJM9	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Complex3 includes MshC as a component of MshC-Zn2+."", ""source_locator"": ""#Complex3/bp:component/#Protein5""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-49_ef6a7c82f185	Reactome:R-MTU-879241	BFO:0000051	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879299		"[{""reference_id"": ""Reactome:R-MTU-879299"", ""source_assertion"": ""BioPAX Complex3 includes Zn2+ as a component of MshC-Zn2+."", ""source_locator"": ""#Complex3/bp:component/#SmallMolecule3""}]"	"[{""id"": ""Reactome:R-MTU-879299"", ""source_sha256"": ""829fcc780929497974de225375e291fe62b5c22b66cfb88a8e17d11d59646cae"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879299 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879299""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-50_29321144c5c9	CHEBI:61548	pathwaymech:consumes	Reactome:R-MTU-879331	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WKI1		"[{""reference_id"": ""UniProtKB:P9WKI1"", ""source_assertion"": ""RHEA:10716 identifies CHEBI:61548 as a substrate."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:10716]""}]"	"[{""id"": ""UniProtKB:P9WKI1"", ""title"": ""Curated catalytic reaction RHEA:10716 for P9WKI1"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WKI1""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-51_95b822943268	Reactome:R-MTU-879331	pathwaymech:produces	CHEBI:58401	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WKI1		"[{""reference_id"": ""UniProtKB:P9WKI1"", ""source_assertion"": ""RHEA:10716 identifies CHEBI:58401 as a product."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:10716]""}]"	"[{""id"": ""UniProtKB:P9WKI1"", ""title"": ""Curated catalytic reaction RHEA:10716 for P9WKI1"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WKI1""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-52_2baa8f259257	CHEBI:58401	pathwaymech:consumes	Reactome:R-MTU-879298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WMY7		"[{""reference_id"": ""UniProtKB:P9WMY7"", ""source_assertion"": ""RHEA:26188 identifies CHEBI:58401 as a substrate."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26188]""}]"	"[{""id"": ""UniProtKB:P9WMY7"", ""title"": ""Curated catalytic reaction RHEA:26188 for P9WMY7"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WMY7""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-53_a2c2343f4f2e	CHEBI:57705	pathwaymech:consumes	Reactome:R-MTU-879298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WMY7		"[{""reference_id"": ""UniProtKB:P9WMY7"", ""source_assertion"": ""RHEA:26188 identifies CHEBI:57705 as a substrate."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26188]""}]"	"[{""id"": ""UniProtKB:P9WMY7"", ""title"": ""Curated catalytic reaction RHEA:26188 for P9WMY7"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WMY7""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-54_6f56d248e6ac	Reactome:R-MTU-879298	pathwaymech:produces	CHEBI:58892	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WMY7		"[{""reference_id"": ""UniProtKB:P9WMY7"", ""source_assertion"": ""RHEA:26188 identifies CHEBI:58892 as a product."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26188]""}]"	"[{""id"": ""UniProtKB:P9WMY7"", ""title"": ""Curated catalytic reaction RHEA:26188 for P9WMY7"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WMY7""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-55_09e45cabe537	Reactome:R-MTU-879298	pathwaymech:produces	CHEBI:58223	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WMY7		"[{""reference_id"": ""UniProtKB:P9WMY7"", ""source_assertion"": ""RHEA:26188 identifies CHEBI:58223 as a product."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26188]""}]"	"[{""id"": ""UniProtKB:P9WMY7"", ""title"": ""Curated catalytic reaction RHEA:26188 for P9WMY7"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WMY7""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-56_362e38f249a5	Reactome:R-MTU-879298	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WMY7		"[{""reference_id"": ""UniProtKB:P9WMY7"", ""source_assertion"": ""RHEA:26188 identifies CHEBI:15378 as a product."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26188]""}]"	"[{""id"": ""UniProtKB:P9WMY7"", ""title"": ""Curated catalytic reaction RHEA:26188 for P9WMY7"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WMY7""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-57_954025586f1b	CHEBI:58886	pathwaymech:consumes	Reactome:R-MTU-879319	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJM9		"[{""reference_id"": ""UniProtKB:P9WJM9"", ""source_assertion"": ""RHEA:26176 identifies CHEBI:58886 as a substrate."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26176]""}]"	"[{""id"": ""UniProtKB:P9WJM9"", ""title"": ""Curated catalytic reaction RHEA:26176 for P9WJM9"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJM9""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-58_7116b94b7944	CHEBI:35235	pathwaymech:consumes	Reactome:R-MTU-879319	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJM9		"[{""reference_id"": ""UniProtKB:P9WJM9"", ""source_assertion"": ""RHEA:26176 identifies CHEBI:35235 as a substrate."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26176]""}]"	"[{""id"": ""UniProtKB:P9WJM9"", ""title"": ""Curated catalytic reaction RHEA:26176 for P9WJM9"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJM9""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-59_388bf594f1cc	CHEBI:30616	pathwaymech:consumes	Reactome:R-MTU-879319	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJM9		"[{""reference_id"": ""UniProtKB:P9WJM9"", ""source_assertion"": ""RHEA:26176 identifies CHEBI:30616 as a substrate."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26176]""}]"	"[{""id"": ""UniProtKB:P9WJM9"", ""title"": ""Curated catalytic reaction RHEA:26176 for P9WJM9"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJM9""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-60_2d1a98cfefb3	Reactome:R-MTU-879319	pathwaymech:produces	CHEBI:58887	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJM9		"[{""reference_id"": ""UniProtKB:P9WJM9"", ""source_assertion"": ""RHEA:26176 identifies CHEBI:58887 as a product."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26176]""}]"	"[{""id"": ""UniProtKB:P9WJM9"", ""title"": ""Curated catalytic reaction RHEA:26176 for P9WJM9"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJM9""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-61_19113b27fd9c	Reactome:R-MTU-879319	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJM9		"[{""reference_id"": ""UniProtKB:P9WJM9"", ""source_assertion"": ""RHEA:26176 identifies CHEBI:456215 as a product."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26176]""}]"	"[{""id"": ""UniProtKB:P9WJM9"", ""title"": ""Curated catalytic reaction RHEA:26176 for P9WJM9"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJM9""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-62_91d7dbd32281	Reactome:R-MTU-879319	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJM9		"[{""reference_id"": ""UniProtKB:P9WJM9"", ""source_assertion"": ""RHEA:26176 identifies CHEBI:33019 as a product."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26176]""}]"	"[{""id"": ""UniProtKB:P9WJM9"", ""title"": ""Curated catalytic reaction RHEA:26176 for P9WJM9"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJM9""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-63_ee5dd795760e	Reactome:R-MTU-879319	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJM9		"[{""reference_id"": ""UniProtKB:P9WJM9"", ""source_assertion"": ""RHEA:26176 identifies CHEBI:15378 as a product."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26176]""}]"	"[{""id"": ""UniProtKB:P9WJM9"", ""title"": ""Curated catalytic reaction RHEA:26176 for P9WJM9"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJM9""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-64_b2c3548d2f0b	CHEBI:58887	pathwaymech:consumes	Reactome:R-MTU-879248	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJM7		"[{""reference_id"": ""UniProtKB:P9WJM7"", ""source_assertion"": ""RHEA:26172 identifies CHEBI:58887 as a substrate."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26172]""}]"	"[{""id"": ""UniProtKB:P9WJM7"", ""title"": ""Curated catalytic reaction RHEA:26172 for P9WJM7"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJM7""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-65_6651d56278ce	CHEBI:57288	pathwaymech:consumes	Reactome:R-MTU-879248	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJM7		"[{""reference_id"": ""UniProtKB:P9WJM7"", ""source_assertion"": ""RHEA:26172 identifies CHEBI:57288 as a substrate."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26172]""}]"	"[{""id"": ""UniProtKB:P9WJM7"", ""title"": ""Curated catalytic reaction RHEA:26172 for P9WJM7"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJM7""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-66_6c35f89dc496	Reactome:R-MTU-879248	pathwaymech:produces	CHEBI:16768	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJM7		"[{""reference_id"": ""UniProtKB:P9WJM7"", ""source_assertion"": ""RHEA:26172 identifies CHEBI:16768 as a product."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26172]""}]"	"[{""id"": ""UniProtKB:P9WJM7"", ""title"": ""Curated catalytic reaction RHEA:26172 for P9WJM7"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJM7""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-67_8274feb36b7c	Reactome:R-MTU-879248	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJM7		"[{""reference_id"": ""UniProtKB:P9WJM7"", ""source_assertion"": ""RHEA:26172 identifies CHEBI:57287 as a product."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26172]""}]"	"[{""id"": ""UniProtKB:P9WJM7"", ""title"": ""Curated catalytic reaction RHEA:26172 for P9WJM7"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJM7""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-68_a3cb3c48e34a	Reactome:R-MTU-879248	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJM7		"[{""reference_id"": ""UniProtKB:P9WJM7"", ""source_assertion"": ""RHEA:26172 identifies CHEBI:15378 as a product."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26172]""}]"	"[{""id"": ""UniProtKB:P9WJM7"", ""title"": ""Curated catalytic reaction RHEA:26172 for P9WJM7"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJM7""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-69_c5b81e744b45	CHEBI:52442	pathwaymech:consumes	RHEA:26180	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJN3		"[{""reference_id"": ""UniProtKB:P9WJN3"", ""source_assertion"": ""MshB catalyzes GlcNAc-Ins deacetylation to glucosaminyl-inositol and acetate (RHEA:26180)."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26180]""}]"	"[{""id"": ""UniProtKB:P9WJN3"", ""source_version"": ""UniProt entry retrieved 2026-10-05"", ""title"": ""MshB mycothiol-biosynthesis deacetylase"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJN3""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-70_9be2b48690f0	CHEBI:15377	pathwaymech:consumes	RHEA:26180	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJN3		"[{""reference_id"": ""UniProtKB:P9WJN3"", ""source_assertion"": ""MshB catalyzes GlcNAc-Ins deacetylation to glucosaminyl-inositol and acetate (RHEA:26180)."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26180]""}]"	"[{""id"": ""UniProtKB:P9WJN3"", ""source_version"": ""UniProt entry retrieved 2026-10-05"", ""title"": ""MshB mycothiol-biosynthesis deacetylase"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJN3""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-71_786f0f4de23f	RHEA:26180	pathwaymech:produces	CHEBI:58886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJN3		"[{""reference_id"": ""UniProtKB:P9WJN3"", ""source_assertion"": ""MshB catalyzes GlcNAc-Ins deacetylation to glucosaminyl-inositol and acetate (RHEA:26180)."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26180]""}]"	"[{""id"": ""UniProtKB:P9WJN3"", ""source_version"": ""UniProt entry retrieved 2026-10-05"", ""title"": ""MshB mycothiol-biosynthesis deacetylase"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJN3""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-72_443d5a7f804d	RHEA:26180	pathwaymech:produces	CHEBI:30089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJN3		"[{""reference_id"": ""UniProtKB:P9WJN3"", ""source_assertion"": ""MshB catalyzes GlcNAc-Ins deacetylation to glucosaminyl-inositol and acetate (RHEA:26180)."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26180]""}]"	"[{""id"": ""UniProtKB:P9WJN3"", ""source_version"": ""UniProt entry retrieved 2026-10-05"", ""title"": ""MshB mycothiol-biosynthesis deacetylase"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJN3""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-73_a5b0cd2a045e	UniProtKB:P9WJN3	pathwaymech:catalyzes	RHEA:26180	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJN3		"[{""reference_id"": ""UniProtKB:P9WJN3"", ""source_assertion"": ""MshB catalyzes GlcNAc-Ins deacetylation to glucosaminyl-inositol and acetate (RHEA:26180)."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:26180]""}]"	"[{""id"": ""UniProtKB:P9WJN3"", ""source_version"": ""UniProt entry retrieved 2026-10-05"", ""title"": ""MshB mycothiol-biosynthesis deacetylase"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJN3""}]"	""
pathwaymech:Reactome_R-MTU-879299_causal-review-74_a5ceb65f9779	CHEBI:29105	pathwaymech:enables	RHEA:26180	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJN3		"[{""reference_id"": ""UniProtKB:P9WJN3"", ""source_assertion"": ""MshB binds one zinc ion per subunit."", ""source_locator"": ""comments[commentType=COFACTOR]; evidence PMID:12958317, PMID:16630724""}]"	"[{""id"": ""UniProtKB:P9WJN3"", ""source_version"": ""UniProt entry retrieved 2026-10-05"", ""title"": ""MshB mycothiol-biosynthesis deacetylase"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJN3""}]"	""
pathwaymech:Reactome_R-MTU-879299_cofactor-cc1effaaf727_a26839fde021	UniProtKB:P9WKI1	pathwaymech:has_cofactor	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WKI1	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q8A7J8)	"[{""reference_id"": ""UniProtKB:P9WKI1"", ""source_assertion"": ""UniProtKB:P9WKI1 annotates CHEBI:57540 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/40/comments/0/cofactors/0""}]"	"[{""id"": ""UniProtKB:P9WKI1"", ""title"": ""Curated catalytic reaction RHEA:10716 for P9WKI1"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WKI1""}]"	""
pathwaymech:Reactome_R-MTU-879299_cofactor-94cc0fadb93c_2790a1f68484	UniProtKB:P9WJN1	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJN1	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_01482); ECO:0000269 (PubMed:26044118) Appears to be a Fe(2+)-dependent enzyme under physiological anaerobic conditions (PubMed:26044118). Binds Zn(2+) under aerobic conditions; this experimental artifact could become biologically relevant under oxidatively stressed conditions, such as those encountered inside activated macrophages (PubMed:14556638, PubMed:26044118). UniProt note evidence: ECO:0000269 (PubMed:14556638); ECO:0000269 (PubMed:26044118)	"[{""reference_id"": ""UniProtKB:P9WJN1"", ""source_assertion"": ""UniProtKB:P9WJN1 annotates CHEBI:29033 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/32/comments/0/cofactors/0; /results/32/comments/0/note""}]"	"[{""id"": ""UniProtKB:P9WJN1"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P9WJN1 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:Reactome_R-MTU-879299_cofactor-0cbc2ed0c71d_c4eecdac81fc	UniProtKB:P9WJM9	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJM9	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 zinc ion per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P9WJM9"", ""source_assertion"": ""UniProtKB:P9WJM9 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/44/comments/0/cofactors/0; /results/44/comments/0/note""}]"	"[{""id"": ""UniProtKB:P9WJM9"", ""title"": ""Curated catalytic reaction RHEA:26176 for P9WJM9"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJM9""}]"	""
pathwaymech:Reactome_R-MTU-879299_cofactor-48fbd5527adb_fba608f9ead1	UniProtKB:P9WJN3	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJN3	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:12958317); ECO:0000269 (PubMed:16630724) Binds 1 zinc ion per subunit. UniProt note evidence: ECO:0000269 (PubMed:12958317); ECO:0000269 (PubMed:16630724)	"[{""reference_id"": ""UniProtKB:P9WJN3"", ""source_assertion"": ""UniProtKB:P9WJN3 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AH6LB59+OR+accession%3AH6LB60+OR+accession%3AH6LB61+OR+accession%3AH6LB62+OR+accession%3AH6LB64+OR+accession%3AH6LB65+OR+accession%3AH6LBE7+OR+accession%3AH6LBX4+OR+accession%3AH6LBX5+OR+accession%3AH6LBX6+OR+accession%3AH6LD21+OR+accession%3AH6LFG3+OR+accession%3AH6LFG4+OR+accession%3AH6LJY6+OR+accession%3AP9WJN3&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:58c69edf7b795ede960dadfaf0093c56d2e871e90536ef0184f021222ecc1321] #/results/0/comments/0/cofactors/0; /results/0/comments/0/note""}]"	"[{""id"": ""UniProtKB:P9WJN3"", ""source_version"": ""UniProt entry retrieved 2026-10-05"", ""title"": ""MshB mycothiol-biosynthesis deacetylase"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJN3""}]"	""
pathwaymech:Reactome_R-MTU-879325_causal-review-1_6ca4c5a0f176	CHEBI:15377	pathwaymech:consumes	Reactome:R-MTU-879281	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879325		"[{""reference_id"": ""Reactome:R-MTU-879325"", ""source_assertion"": ""BioPAX BiochemicalReaction1 lists H2O on its left side with LEFT-TO-RIGHT conversionDirection."", ""source_locator"": ""#BiochemicalReaction1/bp:left/#SmallMolecule2""}]"	"[{""id"": ""Reactome:R-MTU-879325"", ""source_sha256"": ""fa5ca6c86df3e09e7c865b24a9cf5be02a0d17820455dd7aebf8be31d5930639"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879325 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879325""}]"	""
pathwaymech:Reactome_R-MTU-879325_causal-review-2_de6deb8791d3	Reactome:R-MTU-879281	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879325		"[{""reference_id"": ""Reactome:R-MTU-879325"", ""source_assertion"": ""The physical participants of BioPAX BiochemicalReaction1 are assigned to the cytosol."", ""source_locator"": ""#BiochemicalReaction1; participating physicalEntity/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879325"", ""source_sha256"": ""fa5ca6c86df3e09e7c865b24a9cf5be02a0d17820455dd7aebf8be31d5930639"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879325 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879325""}]"	""
pathwaymech:Reactome_R-MTU-879325_causal-review-3_a99fa204b61f	Reactome:R-MTU-879260	pathwaymech:catalyzes	Reactome:R-MTU-879281	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879325	The native zinc-bound Mca assembly represents the aerobic purified form; Fe2+ is favored under physiological anaerobic conditions (PMID:26044118).	"[{""reference_id"": ""Reactome:R-MTU-879325"", ""source_assertion"": ""BioPAX Catalysis1 identifies mca:Zn2+ as the controller of BiochemicalReaction1."", ""source_locator"": ""#Catalysis1/bp:controller/#Complex1; bp:controlled/#BiochemicalReaction1""}]"	"[{""id"": ""Reactome:R-MTU-879325"", ""source_sha256"": ""fa5ca6c86df3e09e7c865b24a9cf5be02a0d17820455dd7aebf8be31d5930639"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879325 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879325""}]"	""
pathwaymech:Reactome_R-MTU-879325_causal-review-4_b614d7c9104a	CHEBI:15377	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879325		"[{""reference_id"": ""Reactome:R-MTU-879325"", ""source_assertion"": ""BioPAX SmallMolecule2 assigns H2O to the cytosol."", ""source_locator"": ""#SmallMolecule2/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879325"", ""source_sha256"": ""fa5ca6c86df3e09e7c865b24a9cf5be02a0d17820455dd7aebf8be31d5930639"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879325 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879325""}]"	""
pathwaymech:Reactome_R-MTU-879325_causal-review-5_5a87412381a2	CHEBI:29105	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879325		"[{""reference_id"": ""Reactome:R-MTU-879325"", ""source_assertion"": ""BioPAX SmallMolecule5 assigns Zn2+ to the cytosol."", ""source_locator"": ""#SmallMolecule5/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879325"", ""source_sha256"": ""fa5ca6c86df3e09e7c865b24a9cf5be02a0d17820455dd7aebf8be31d5930639"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879325 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879325""}]"	""
pathwaymech:Reactome_R-MTU-879325_causal-review-6_68ba535c7249	UniProtKB:P9WJN1	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879325		"[{""reference_id"": ""Reactome:R-MTU-879325"", ""source_assertion"": ""BioPAX Protein1 assigns mca to the cytosol."", ""source_locator"": ""#Protein1/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879325"", ""source_sha256"": ""fa5ca6c86df3e09e7c865b24a9cf5be02a0d17820455dd7aebf8be31d5930639"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879325 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879325""}]"	""
pathwaymech:Reactome_R-MTU-879325_causal-review-7_d95f2788e375	Reactome:R-MTU-879260	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879325		"[{""reference_id"": ""Reactome:R-MTU-879325"", ""source_assertion"": ""BioPAX Complex1 assigns mca:Zn2+ to the cytosol."", ""source_locator"": ""#Complex1/bp:cellularLocation/#CellularLocationVocabulary1""}]"	"[{""id"": ""Reactome:R-MTU-879325"", ""source_sha256"": ""fa5ca6c86df3e09e7c865b24a9cf5be02a0d17820455dd7aebf8be31d5930639"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879325 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879325""}]"	""
pathwaymech:Reactome_R-MTU-879325_causal-review-8_59f175689709	Reactome:R-MTU-879260	BFO:0000051	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879325		"[{""reference_id"": ""Reactome:R-MTU-879325"", ""source_assertion"": ""BioPAX Complex1 includes Zn2+ as a component of mca:Zn2+."", ""source_locator"": ""#Complex1/bp:component/#SmallMolecule5""}]"	"[{""id"": ""Reactome:R-MTU-879325"", ""source_sha256"": ""fa5ca6c86df3e09e7c865b24a9cf5be02a0d17820455dd7aebf8be31d5930639"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879325 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879325""}]"	""
pathwaymech:Reactome_R-MTU-879325_causal-review-9_0822428aff89	Reactome:R-MTU-879260	BFO:0000051	UniProtKB:P9WJN1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	Reactome:R-MTU-879325		"[{""reference_id"": ""Reactome:R-MTU-879325"", ""source_assertion"": ""BioPAX Complex1 includes mca as a component of mca:Zn2+."", ""source_locator"": ""#Complex1/bp:component/#Protein1""}]"	"[{""id"": ""Reactome:R-MTU-879325"", ""source_sha256"": ""fa5ca6c86df3e09e7c865b24a9cf5be02a0d17820455dd7aebf8be31d5930639"", ""source_version"": ""Reactome BioPAX 97"", ""title"": ""R-MTU-879325 native structured pathway source"", ""url"": ""https://reactome.org/ReactomeRESTfulAPI/RESTfulWS/biopaxExporter/Level3/879325""}]"	""
pathwaymech:Reactome_R-MTU-879325_causal-review-10_a259b5495470	CHEBI:59633	pathwaymech:consumes	Reactome:R-MTU-879281	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJN1		"[{""reference_id"": ""UniProtKB:P9WJN1"", ""source_assertion"": ""Mca hydrolyzes a mycothiol S-conjugate to an S-substituted N-acetyl-L-cysteinate and glucosaminyl-inositol (RHEA:36543); the substrate is not unconjugated mycothiol."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:36543]""}]"	"[{""id"": ""UniProtKB:P9WJN1"", ""source_version"": ""UniProt entry retrieved 2026-10-05"", ""title"": ""Mycothiol S-conjugate amidase Mca; curated catalytic reaction RHEA:36543"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJN1""}]"	""
pathwaymech:Reactome_R-MTU-879325_causal-review-11_a2f5b54a6438	Reactome:R-MTU-879281	pathwaymech:produces	CHEBI:58718	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJN1		"[{""reference_id"": ""UniProtKB:P9WJN1"", ""source_assertion"": ""Mca hydrolyzes a mycothiol S-conjugate to an S-substituted N-acetyl-L-cysteinate and glucosaminyl-inositol (RHEA:36543); the substrate is not unconjugated mycothiol."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:36543]""}]"	"[{""id"": ""UniProtKB:P9WJN1"", ""source_version"": ""UniProt entry retrieved 2026-10-05"", ""title"": ""Mycothiol S-conjugate amidase Mca; curated catalytic reaction RHEA:36543"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJN1""}]"	""
pathwaymech:Reactome_R-MTU-879325_causal-review-12_4a2c081573a1	Reactome:R-MTU-879281	pathwaymech:produces	CHEBI:58886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJN1		"[{""reference_id"": ""UniProtKB:P9WJN1"", ""source_assertion"": ""Mca hydrolyzes a mycothiol S-conjugate to an S-substituted N-acetyl-L-cysteinate and glucosaminyl-inositol (RHEA:36543); the substrate is not unconjugated mycothiol."", ""source_locator"": ""comments[commentType=CATALYTIC ACTIVITY].reaction[RHEA:36543]""}]"	"[{""id"": ""UniProtKB:P9WJN1"", ""source_version"": ""UniProt entry retrieved 2026-10-05"", ""title"": ""Mycothiol S-conjugate amidase Mca; curated catalytic reaction RHEA:36543"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJN1""}]"	""
pathwaymech:Reactome_R-MTU-879325_causal-review-13_1bfe23e8ba36	CHEBI:29033	pathwaymech:enables	Reactome:R-MTU-879281	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:26044118	Cofactor assignment is conditional: anaerobic Fe2+ form; the retained Reactome Zn2+ complex is the aerobic form.	"[{""reference_id"": ""PMID:26044118"", ""source_assertion"": ""Mca purified under anaerobic conditions contains stoichiometric Fe2+; the authors favor Fe2+-dependent activity under physiological conditions."", ""source_locator"": ""Abstract: anaerobic versus aerobic Halo-Mca pull-down experiments""}]"	"[{""id"": ""PMID:26044118"", ""title"": ""Identity of cofactor bound to mycothiol conjugate amidase (Mca) influenced by expression and purification conditions"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/26044118/""}]"	""
pathwaymech:Reactome_R-MTU-879325_cofactor-94cc0fadb93c_760447609167	UniProtKB:P9WJN1	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P9WJN1	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_01482); ECO:0000269 (PubMed:26044118) Appears to be a Fe(2+)-dependent enzyme under physiological anaerobic conditions (PubMed:26044118). Binds Zn(2+) under aerobic conditions; this experimental artifact could become biologically relevant under oxidatively stressed conditions, such as those encountered inside activated macrophages (PubMed:14556638, PubMed:26044118). UniProt note evidence: ECO:0000269 (PubMed:14556638); ECO:0000269 (PubMed:26044118)	"[{""reference_id"": ""UniProtKB:P9WJN1"", ""source_assertion"": ""UniProtKB:P9WJN1 annotates CHEBI:29033 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/32/comments/0/cofactors/0; /results/32/comments/0/note""}]"	"[{""id"": ""UniProtKB:P9WJN1"", ""source_version"": ""UniProt entry retrieved 2026-10-05"", ""title"": ""Mycothiol S-conjugate amidase Mca; curated catalytic reaction RHEA:36543"", ""url"": ""https://www.uniprot.org/uniprotkb/P9WJN1""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-001_e3c230a2db9f	gomodel:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN	RO:0002234	CHEBI:58401	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_58401_MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/0; endpoint types: /individuals/5/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-002_20a765b4d629	gomodel:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN	BFO:0000050	GO:0006021	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN BFO:0000050 gomodel:YeastPathways_PWY-2301/YeastPathways_PWY-2301."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/1; endpoint types: /individuals/6/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-003_808b15a7b419	gomodel:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN	RO:0002234	CHEBI:17268	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN RO:0002234 gomodel:CHEBI_17268_MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/2; endpoint types: /individuals/6/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-004_09f2996c6677	gomodel:YeastPathways_PWY-2301/6a2b236300005397	RO:0002233	CHEBI:58401	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-2301/6a2b236300005397 RO:0002233 gomodel:CHEBI_58401_MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/3; endpoint types: /individuals/20/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-005_3c410c2148e0	gomodel:YeastPathways_PWY-2301/6a2b236300005397	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-2301/6a2b236300005397 BFO:0000066 gomodel:YeastPathways_PWY-2301/6a2b236300005403."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/4; endpoint types: /individuals/20/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-006_648cd874883b	SGD:S000003689	pathwaymech:enables	gomodel:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN RO:0002333 gomodel:YeastPathways_PWY-2301/654d809000001026."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/5; endpoint types: /individuals/5/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-007_24d69e4047e8	gomodel:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN	RO:0002233	CHEBI:58401	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN RO:0002233 gomodel:CHEBI_58401_MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/6; endpoint types: /individuals/6/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-008_a6dc8340755d	gomodel:YeastPathways_PWY-2301/6a2b236300005397	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-2301/6a2b236300005397 RO:0002234 gomodel:YeastPathways_PWY-2301/6a2b236300005400."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/7; endpoint types: /individuals/20/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-009_8b18a4d2b23b	gomodel:YeastPathways_PWY-2301/6a2b236300005397	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-2301/6a2b236300005397 RO:0002233 gomodel:YeastPathways_PWY-2301/6a2b236300005398."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/8; endpoint types: /individuals/20/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-010_4e285f8e7905	gomodel:YeastPathways_PWY-2301/6a2b236300005397	RO:0002234	CHEBI:17268	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-2301/6a2b236300005397 RO:0002234 gomodel:YeastPathways_PWY-2301/6a2b236300005399."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/9; endpoint types: /individuals/20/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-011_2fc99b6c50c1	gomodel:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN RO:0002233 gomodel:CHEBI_15377_MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/10; endpoint types: /individuals/6/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-012_2b1416b4b184	gomodel:YeastPathways_PWY-2301/6a2b236300005397	BFO:0000050	GO:0006021	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-2301/6a2b236300005397 BFO:0000050 gomodel:YeastPathways_PWY-2301/YeastPathways_PWY-2301."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/11; endpoint types: /individuals/20/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-013_508bce9c28dc	gomodel:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN BFO:0000066 gomodel:reaction_MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/12; endpoint types: /individuals/6/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-014_24a89004834a	gomodel:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN RO:0002234 gomodel:CHEBI_43474_MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/13; endpoint types: /individuals/6/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-015_4456c83c2828	gomodel:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN	RO:0002233	CHEBI:4170	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_4170_MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/14; endpoint types: /individuals/5/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-016_0442dd66dcf5	gomodel:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN	BFO:0000050	GO:0006021	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN BFO:0000050 gomodel:YeastPathways_PWY-2301/YeastPathways_PWY-2301."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/15; endpoint types: /individuals/5/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-017_06809e80ad4b	gomodel:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN BFO:0000066 gomodel:reaction_MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/16; endpoint types: /individuals/5/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-018_e82593cfeeaf	SGD:S000002695	pathwaymech:enables	gomodel:YeastPathways_PWY-2301/6a2b236300005397	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-2301/6a2b236300005397 RO:0002333 gomodel:YeastPathways_PWY-2301/6a2b236300005401."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/17; endpoint types: /individuals/20/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_edge-019_e65975cfb49a	SGD:S000001088	pathwaymech:enables	gomodel:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-2301		"[{""reference_id"": ""gomodel:YeastPathways_PWY-2301"", ""source_assertion"": ""The model asserts gomodel:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN RO:0002333 gomodel:YHR046C-MONOMER_MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-2301.json#/facts/18; endpoint types: /individuals/6/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-2301"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-2301.json"", ""title"": ""GO-CAM myo-inositol biosynthesis model YeastPathways_PWY-2301"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_location-81e87f71ac03_5a0300132507	SGD:S000003689	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P11986	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P11986"", ""source_assertion"": ""UniProtKB:P11986 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/341/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P11986"", ""source_assertion"": ""UniProtKB:P11986 has the exact SGD cross-reference SGD:S000003689."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/341/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P11986"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P11986 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_location-e7a26860ae9f_40a49ab19ab9	SGD:S000001088	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38710	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38710"", ""source_assertion"": ""UniProtKB:P38710 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1417/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38710"", ""source_assertion"": ""UniProtKB:P38710 has the exact SGD cross-reference SGD:S000001088."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1417/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38710"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38710 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_location-64bda3d62f6b_05307e4b8b62	SGD:S000001088	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38710	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38710"", ""source_assertion"": ""UniProtKB:P38710 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1417/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38710"", ""source_assertion"": ""UniProtKB:P38710 has the exact SGD cross-reference SGD:S000001088."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1417/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38710"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38710 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_cofactor-49696fa98d23_731c96395a52	SGD:S000003689	pathwaymech:has_cofactor	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P11986	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:11779862); ECO:0000269 (PubMed:12832758); ECO:0000269 (PubMed:12836703); ECO:0000269 (PubMed:14684747); ECO:0000269 (Reference:Ref.6)	"[{""reference_id"": ""UniProtKB:P11986"", ""source_assertion"": ""UniProtKB:P11986 annotates CHEBI:57540 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/341/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P11986"", ""source_assertion"": ""UniProtKB:P11986 has the exact SGD cross-reference SGD:S000003689."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/341/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P11986"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P11986 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_cofactor-07dfa3a89aea_f5d248abc26c	SGD:S000002695	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q05533	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:Q05533"", ""source_assertion"": ""UniProtKB:Q05533 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4150/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:Q05533"", ""source_assertion"": ""UniProtKB:Q05533 has the exact SGD cross-reference SGD:S000002695."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4150/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q05533"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB Q05533 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-2301_cofactor-0901c1c8d7b7_59288d24b98a	SGD:S000001088	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38710	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P38710"", ""source_assertion"": ""UniProtKB:P38710 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1417/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P38710"", ""source_assertion"": ""UniProtKB:P38710 has the exact SGD cross-reference SGD:S000001088."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1417/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38710"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38710 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-001_8e225680a3b1	MetaCyc:DHBAMPLIG-RXN	BFO:0000050	MetaCyc:PWY-8383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-8383	Complete native member: DHB adenylation.	"[{""reference_id"": ""MetaCyc:PWY-8383"", ""source_assertion"": ""The native pathway directly includes DHBAMPLIG-RXN among nine reaction members. PWY-5901 is separately linked precursor supply, not a nested member."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-8383\""]/reaction-list/Reaction[@frameid=\""DHBAMPLIG-RXN\""]; /ptools-xml/Pathway/pathway-link""}]"	"[{""id"": ""MetaCyc:PWY-8383"", ""source_sha256"": ""5dff3f18293a1a0ef8087b4956f2cb03023dd912e6d64055a388e5e3d7f15881"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-8383"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PWY-8383""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-002_d9d143cde020	MetaCyc:RXN-23310	BFO:0000050	MetaCyc:PWY-8383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-8383	Complete native member: DHB loading onto MxcF.	"[{""reference_id"": ""MetaCyc:PWY-8383"", ""source_assertion"": ""The native pathway directly includes RXN-23310 among nine reaction members. PWY-5901 is separately linked precursor supply, not a nested member."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-8383\""]/reaction-list/Reaction[@frameid=\""RXN-23310\""]; /ptools-xml/Pathway/pathway-link""}]"	"[{""id"": ""MetaCyc:PWY-8383"", ""source_sha256"": ""5dff3f18293a1a0ef8087b4956f2cb03023dd912e6d64055a388e5e3d7f15881"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-8383"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PWY-8383""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-003_aabed141b362	MetaCyc:RXN-22679	BFO:0000050	MetaCyc:PWY-8383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-8383	Complete native member: L-lysine adenylation.	"[{""reference_id"": ""MetaCyc:PWY-8383"", ""source_assertion"": ""The native pathway directly includes RXN-22679 among nine reaction members. PWY-5901 is separately linked precursor supply, not a nested member."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-8383\""]/reaction-list/Reaction[@frameid=\""RXN-22679\""]; /ptools-xml/Pathway/pathway-link""}]"	"[{""id"": ""MetaCyc:PWY-8383"", ""source_sha256"": ""5dff3f18293a1a0ef8087b4956f2cb03023dd912e6d64055a388e5e3d7f15881"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-8383"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PWY-8383""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-004_74fc28669ef2	MetaCyc:RXN-23308	BFO:0000050	MetaCyc:PWY-8383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-8383	Complete native member: L-lysine loading onto MxcG.	"[{""reference_id"": ""MetaCyc:PWY-8383"", ""source_assertion"": ""The native pathway directly includes RXN-23308 among nine reaction members. PWY-5901 is separately linked precursor supply, not a nested member."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-8383\""]/reaction-list/Reaction[@frameid=\""RXN-23308\""]; /ptools-xml/Pathway/pathway-link""}]"	"[{""id"": ""MetaCyc:PWY-8383"", ""source_sha256"": ""5dff3f18293a1a0ef8087b4956f2cb03023dd912e6d64055a388e5e3d7f15881"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-8383"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PWY-8383""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-005_984a91aef1eb	MetaCyc:RXN-23316	BFO:0000050	MetaCyc:PWY-8383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-8383|PMID:11562468	Complete native member: first DHB condensation (native N6-first convention). N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""MetaCyc:PWY-8383"", ""source_assertion"": ""The native pathway directly includes RXN-23316 among nine reaction members. PWY-5901 is separately linked precursor supply, not a nested member."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-8383\""]/reaction-list/Reaction[@frameid=\""RXN-23316\""]; /ptools-xml/Pathway/pathway-link""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""MetaCyc:PWY-8383"", ""source_sha256"": ""5dff3f18293a1a0ef8087b4956f2cb03023dd912e6d64055a388e5e3d7f15881"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-8383"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PWY-8383""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-006_838ed224fcce	MetaCyc:RXN-23312	BFO:0000050	MetaCyc:PWY-8383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-8383|PMID:11562468	Complete native member: second DHB condensation. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""MetaCyc:PWY-8383"", ""source_assertion"": ""The native pathway directly includes RXN-23312 among nine reaction members. PWY-5901 is separately linked precursor supply, not a nested member."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-8383\""]/reaction-list/Reaction[@frameid=\""RXN-23312\""]; /ptools-xml/Pathway/pathway-link""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""MetaCyc:PWY-8383"", ""source_sha256"": ""5dff3f18293a1a0ef8087b4956f2cb03023dd912e6d64055a388e5e3d7f15881"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-8383"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PWY-8383""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-007_ebe5664b07da	MetaCyc:RXN-23313	BFO:0000050	MetaCyc:PWY-8383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-8383	Complete native member: reductive carrier release to the aldehyde.	"[{""reference_id"": ""MetaCyc:PWY-8383"", ""source_assertion"": ""The native pathway directly includes RXN-23313 among nine reaction members. PWY-5901 is separately linked precursor supply, not a nested member."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-8383\""]/reaction-list/Reaction[@frameid=\""RXN-23313\""]; /ptools-xml/Pathway/pathway-link""}]"	"[{""id"": ""MetaCyc:PWY-8383"", ""source_sha256"": ""5dff3f18293a1a0ef8087b4956f2cb03023dd912e6d64055a388e5e3d7f15881"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-8383"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PWY-8383""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-008_9001dcb1b921	MetaCyc:RXN-23314	BFO:0000050	MetaCyc:PWY-8383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-8383	Complete native member: aldehyde reduction to myxochelin A.	"[{""reference_id"": ""MetaCyc:PWY-8383"", ""source_assertion"": ""The native pathway directly includes RXN-23314 among nine reaction members. PWY-5901 is separately linked precursor supply, not a nested member."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-8383\""]/reaction-list/Reaction[@frameid=\""RXN-23314\""]; /ptools-xml/Pathway/pathway-link""}]"	"[{""id"": ""MetaCyc:PWY-8383"", ""source_sha256"": ""5dff3f18293a1a0ef8087b4956f2cb03023dd912e6d64055a388e5e3d7f15881"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-8383"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PWY-8383""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-009_8a00189383b5	MetaCyc:RXN-23315	BFO:0000050	MetaCyc:PWY-8383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-8383	Complete native member: aldehyde transamination to myxochelin B.	"[{""reference_id"": ""MetaCyc:PWY-8383"", ""source_assertion"": ""The native pathway directly includes RXN-23315 among nine reaction members. PWY-5901 is separately linked precursor supply, not a nested member."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-8383\""]/reaction-list/Reaction[@frameid=\""RXN-23315\""]; /ptools-xml/Pathway/pathway-link""}]"	"[{""id"": ""MetaCyc:PWY-8383"", ""source_sha256"": ""5dff3f18293a1a0ef8087b4956f2cb03023dd912e6d64055a388e5e3d7f15881"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-8383"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PWY-8383""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-010_0f0fcc494451	CHEBI:30616	pathwaymech:consumes	MetaCyc:DHBAMPLIG-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:ATP|MetaCyc:DHBAMPLIG-RXN|RHEA:20230	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_assertion"": ""The original left side contains ATP with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""DHBAMPLIG-RXN\""]/left[*[@frameid=\""ATP\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:ATP"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""ATP\""]/inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:30616\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}, {""reference_id"": ""RHEA:20230"", ""source_assertion"": ""The current Rhea forward reaction independently preserves this exact chemical identity and unit coefficient, including diphosphate(3-) and one consumed hydron. It matches the selected native first reaction."", ""source_locator"": ""RDF RHEA:20230/substrates -> http://rdf.rhea-db.org/20229_L/contains1 -> http://rdf.rhea-db.org/Participant_20229_compound_6372/compound -> http://rdf.rhea-db.org/Compound_6372/accession""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI ATP(4-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:ATP"", ""source_sha256"": ""1fc4246b67bb2e45cf6e04a6dfa5e1079da4b8301b11edc6ddb63ba7da2f0615"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native ATP"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:ATP""}, {""id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_sha256"": ""87918421a3ef2314109444083e25ed14907e147bf9b87ff34c5c14b614db8a04"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native DHBAMPLIG-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:DHBAMPLIG-RXN""}, {""id"": ""RHEA:20230"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original gzip RDF; five compound side chains verified against native DHBAMPLIG-RXN"", ""title"": ""Rhea 142 forward 2,3-dihydroxybenzoate adenylation"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-011_077d4d398c2e	CHEBI:36654	pathwaymech:consumes	MetaCyc:DHBAMPLIG-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:36654|MetaCyc:2-3-DIHYDROXYBENZOATE|MetaCyc:DHBAMPLIG-RXN|RHEA:20230	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_assertion"": ""The original left side contains 2-3-DIHYDROXYBENZOATE with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""DHBAMPLIG-RXN\""]/left[*[@frameid=\""2-3-DIHYDROXYBENZOATE\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:2-3-DIHYDROXYBENZOATE"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""2-3-DIHYDROXYBENZOATE\""]/inchi""}, {""reference_id"": ""CHEBI:36654"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:36654\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}, {""reference_id"": ""RHEA:20230"", ""source_assertion"": ""The current Rhea forward reaction independently preserves this exact chemical identity and unit coefficient, including diphosphate(3-) and one consumed hydron. It matches the selected native first reaction."", ""source_locator"": ""RDF RHEA:20230/substrates -> http://rdf.rhea-db.org/20229_L/contains1 -> http://rdf.rhea-db.org/Participant_20229_compound_3751/compound -> http://rdf.rhea-db.org/Compound_3751/accession""}]"	"[{""id"": ""CHEBI:36654"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI 2,3-dihydroxybenzoate"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:2-3-DIHYDROXYBENZOATE"", ""source_sha256"": ""0196374ab6441132e8872323c1ce0850cb4ed692a9ddae71969e6cf7bebdeba0"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native 2-3-DIHYDROXYBENZOATE"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:2-3-DIHYDROXYBENZOATE""}, {""id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_sha256"": ""87918421a3ef2314109444083e25ed14907e147bf9b87ff34c5c14b614db8a04"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native DHBAMPLIG-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:DHBAMPLIG-RXN""}, {""id"": ""RHEA:20230"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original gzip RDF; five compound side chains verified against native DHBAMPLIG-RXN"", ""title"": ""Rhea 142 forward 2,3-dihydroxybenzoate adenylation"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-012_4bb568312feb	CHEBI:15378	pathwaymech:consumes	MetaCyc:DHBAMPLIG-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:DHBAMPLIG-RXN|MetaCyc:PROTON|RHEA:20230	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_assertion"": ""The original left side contains PROTON with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""DHBAMPLIG-RXN\""]/left[*[@frameid=\""PROTON\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""PROTON\""]/inchi""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:15378\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}, {""reference_id"": ""RHEA:20230"", ""source_assertion"": ""The current Rhea forward reaction independently preserves this exact chemical identity and unit coefficient, including diphosphate(3-) and one consumed hydron. It matches the selected native first reaction."", ""source_locator"": ""RDF RHEA:20230/substrates -> http://rdf.rhea-db.org/20229_L/contains1 -> http://rdf.rhea-db.org/Participant_20229_compound_3249/compound -> http://rdf.rhea-db.org/Compound_3249/accession""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI hydron"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_sha256"": ""87918421a3ef2314109444083e25ed14907e147bf9b87ff34c5c14b614db8a04"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native DHBAMPLIG-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:DHBAMPLIG-RXN""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""22115ac465b8f70fb4d34d11e93120cafb805cbc00c2391f21a5a27f1563602f"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PROTON"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PROTON""}, {""id"": ""RHEA:20230"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original gzip RDF; five compound side chains verified against native DHBAMPLIG-RXN"", ""title"": ""Rhea 142 forward 2,3-dihydroxybenzoate adenylation"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-013_f2d438a9db0e	MetaCyc:DHBAMPLIG-RXN	pathwaymech:produces	CHEBI:57417	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:57417|MetaCyc:CPD-62|MetaCyc:DHBAMPLIG-RXN|RHEA:20230	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_assertion"": ""The original right side contains CPD-62 with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""DHBAMPLIG-RXN\""]/right[*[@frameid=\""CPD-62\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-62"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""CPD-62\""]/inchi""}, {""reference_id"": ""CHEBI:57417"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:57417\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}, {""reference_id"": ""RHEA:20230"", ""source_assertion"": ""The current Rhea forward reaction independently preserves this exact chemical identity and unit coefficient, including diphosphate(3-) and one consumed hydron. It matches the selected native first reaction."", ""source_locator"": ""RDF RHEA:20230/products -> http://rdf.rhea-db.org/20229_R/contains1 -> http://rdf.rhea-db.org/Participant_20229_compound_2580/compound -> http://rdf.rhea-db.org/Compound_2580/accession""}]"	"[{""id"": ""CHEBI:57417"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI 2,3-dihydroxybenzoyl 5'-adenylate(1-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:CPD-62"", ""source_sha256"": ""3b87f560cdeb3cc068e155056c79eb9482a917b76c93f4cf69ca273366a83c87"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native CPD-62"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPD-62""}, {""id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_sha256"": ""87918421a3ef2314109444083e25ed14907e147bf9b87ff34c5c14b614db8a04"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native DHBAMPLIG-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:DHBAMPLIG-RXN""}, {""id"": ""RHEA:20230"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original gzip RDF; five compound side chains verified against native DHBAMPLIG-RXN"", ""title"": ""Rhea 142 forward 2,3-dihydroxybenzoate adenylation"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-014_da803d340672	MetaCyc:DHBAMPLIG-RXN	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:33019|MetaCyc:DHBAMPLIG-RXN|MetaCyc:PPI|RHEA:20230	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_assertion"": ""The original right side contains PPI with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""DHBAMPLIG-RXN\""]/right[*[@frameid=\""PPI\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:PPI"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""PPI\""]/inchi""}, {""reference_id"": ""CHEBI:33019"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:33019\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}, {""reference_id"": ""RHEA:20230"", ""source_assertion"": ""The current Rhea forward reaction independently preserves this exact chemical identity and unit coefficient, including diphosphate(3-) and one consumed hydron. It matches the selected native first reaction."", ""source_locator"": ""RDF RHEA:20230/products -> http://rdf.rhea-db.org/20229_R/contains1 -> http://rdf.rhea-db.org/Participant_20229_compound_2106/compound -> http://rdf.rhea-db.org/Compound_2106/accession""}]"	"[{""id"": ""CHEBI:33019"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI diphosphate(3-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_sha256"": ""87918421a3ef2314109444083e25ed14907e147bf9b87ff34c5c14b614db8a04"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native DHBAMPLIG-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:DHBAMPLIG-RXN""}, {""id"": ""MetaCyc:PPI"", ""source_sha256"": ""f05985a2eb421b0377d549dff696bd292908326a80e6f19b18a45a54bac40290"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PPI"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PPI""}, {""id"": ""RHEA:20230"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142 complete original gzip RDF; five compound side chains verified against native DHBAMPLIG-RXN"", ""title"": ""Rhea 142 forward 2,3-dihydroxybenzoate adenylation"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-015_5320610ba22b	CHEBI:57417	pathwaymech:consumes	MetaCyc:RXN-23310	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:57417|MetaCyc:CPD-62|MetaCyc:RXN-23310	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-23310"", ""source_assertion"": ""The original left side contains CPD-62 with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23310\""]/left[*[@frameid=\""CPD-62\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-62"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""CPD-62\""]/inchi""}, {""reference_id"": ""CHEBI:57417"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:57417\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:57417"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI 2,3-dihydroxybenzoyl 5'-adenylate(1-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:CPD-62"", ""source_sha256"": ""3b87f560cdeb3cc068e155056c79eb9482a917b76c93f4cf69ca273366a83c87"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native CPD-62"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPD-62""}, {""id"": ""MetaCyc:RXN-23310"", ""source_sha256"": ""93240fea2e11613e9a624aadb68aa9c0691ef41e05d155c84e9dfc5629a367c9"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23310"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23310""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-016_3b667cbb7c03	MetaCyc:MxcF	pathwaymech:consumes	MetaCyc:RXN-23310	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:MxcF|MetaCyc:RXN-23310	Coefficient: 1. Whole carrier reactive class, not a free acyl group or a fixed number of native protein molecules.	"[{""reference_id"": ""MetaCyc:RXN-23310"", ""source_assertion"": ""The original left side contains MxcF with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23310\""]/left[*[@frameid=\""MxcF\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:MxcF"", ""source_assertion"": ""The original typed Protein class names this whole Mxc carrier reactive state. It does not supply a full molecular formula, engineered construct sequence or measured assembly stoichiometry."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""MxcF\""]/common-name""}]"	"[{""id"": ""MetaCyc:MxcF"", ""source_sha256"": ""166fc987341594d992c90774a2aa486355e901cbb63b6bdb1c21759f69babe9c"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native MxcF"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:MxcF""}, {""id"": ""MetaCyc:RXN-23310"", ""source_sha256"": ""93240fea2e11613e9a624aadb68aa9c0691ef41e05d155c84e9dfc5629a367c9"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23310"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23310""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-017_978cc2ca8bc2	MetaCyc:RXN-23310	pathwaymech:produces	MetaCyc:23-DHB-MxcF	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:23-DHB-MxcF|MetaCyc:RXN-23310	Coefficient: 1. Whole carrier reactive class, not a free acyl group or a fixed number of native protein molecules.	"[{""reference_id"": ""MetaCyc:RXN-23310"", ""source_assertion"": ""The original right side contains 23-DHB-MxcF with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23310\""]/right[*[@frameid=\""23-DHB-MxcF\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:23-DHB-MxcF"", ""source_assertion"": ""The original typed Protein class names this whole Mxc carrier reactive state. It does not supply a full molecular formula, engineered construct sequence or measured assembly stoichiometry."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""23-DHB-MxcF\""]/common-name""}]"	"[{""id"": ""MetaCyc:23-DHB-MxcF"", ""source_sha256"": ""7510aefad9ea7dc25a28574c4fd68cffb52ef611d3c3e413a62867e52359b12e"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native 23-DHB-MxcF"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:23-DHB-MxcF""}, {""id"": ""MetaCyc:RXN-23310"", ""source_sha256"": ""93240fea2e11613e9a624aadb68aa9c0691ef41e05d155c84e9dfc5629a367c9"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23310"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23310""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-018_cf916e9771fa	MetaCyc:RXN-23310	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:456215|MetaCyc:AMP|MetaCyc:RXN-23310	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-23310"", ""source_assertion"": ""The original right side contains AMP with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23310\""]/right[*[@frameid=\""AMP\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:AMP"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""AMP\""]/inchi""}, {""reference_id"": ""CHEBI:456215"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:456215\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:456215"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI adenosine 5'-monophosphate(2-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:AMP"", ""source_sha256"": ""d9ff83dc0e72ac41b27ef552592c61a8f682c26fb131a127789d3093f5614286"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native AMP"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:AMP""}, {""id"": ""MetaCyc:RXN-23310"", ""source_sha256"": ""93240fea2e11613e9a624aadb68aa9c0691ef41e05d155c84e9dfc5629a367c9"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23310"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23310""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-019_820600adf5da	MetaCyc:RXN-23310	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-23310	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-23310"", ""source_assertion"": ""The original right side contains PROTON with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23310\""]/right[*[@frameid=\""PROTON\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""PROTON\""]/inchi""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:15378\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI hydron"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""22115ac465b8f70fb4d34d11e93120cafb805cbc00c2391f21a5a27f1563602f"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PROTON"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PROTON""}, {""id"": ""MetaCyc:RXN-23310"", ""source_sha256"": ""93240fea2e11613e9a624aadb68aa9c0691ef41e05d155c84e9dfc5629a367c9"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23310"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23310""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-020_17730d996f50	CHEBI:32551	pathwaymech:consumes	MetaCyc:RXN-22679	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:32551|MetaCyc:LYS|MetaCyc:RXN-22679	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-22679"", ""source_assertion"": ""The original left side contains LYS with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-22679\""]/left[*[@frameid=\""LYS\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:LYS"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""LYS\""]/inchi""}, {""reference_id"": ""CHEBI:32551"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:32551\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:32551"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI L-lysinium(1+)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:LYS"", ""source_sha256"": ""a0b1902ad46eb1609cb84ab8ff8313f83a3700a06f687501b7dc9027eedd226d"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native LYS"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:LYS""}, {""id"": ""MetaCyc:RXN-22679"", ""source_sha256"": ""02dff777c34ed90d031dc418c88070660ec60ba79055f76b1f3e1718524ee36e"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-22679"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-22679""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-021_45b3591dd214	CHEBI:30616	pathwaymech:consumes	MetaCyc:RXN-22679	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:ATP|MetaCyc:RXN-22679	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-22679"", ""source_assertion"": ""The original left side contains ATP with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-22679\""]/left[*[@frameid=\""ATP\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:ATP"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""ATP\""]/inchi""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:30616\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI ATP(4-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:ATP"", ""source_sha256"": ""1fc4246b67bb2e45cf6e04a6dfa5e1079da4b8301b11edc6ddb63ba7da2f0615"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native ATP"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:ATP""}, {""id"": ""MetaCyc:RXN-22679"", ""source_sha256"": ""02dff777c34ed90d031dc418c88070660ec60ba79055f76b1f3e1718524ee36e"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-22679"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-22679""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-022_92bc8b499aa8	CHEBI:15378	pathwaymech:consumes	MetaCyc:RXN-22679	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-22679	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-22679"", ""source_assertion"": ""The original left side contains PROTON with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-22679\""]/left[*[@frameid=\""PROTON\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""PROTON\""]/inchi""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:15378\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI hydron"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""22115ac465b8f70fb4d34d11e93120cafb805cbc00c2391f21a5a27f1563602f"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PROTON"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PROTON""}, {""id"": ""MetaCyc:RXN-22679"", ""source_sha256"": ""02dff777c34ed90d031dc418c88070660ec60ba79055f76b1f3e1718524ee36e"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-22679"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-22679""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-023_7927e4751a54	MetaCyc:RXN-22679	pathwaymech:produces	CHEBI:176581	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:176581|MetaCyc:CPD-24910|MetaCyc:RXN-22679	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-22679"", ""source_assertion"": ""The original right side contains CPD-24910 with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-22679\""]/right[*[@frameid=\""CPD-24910\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-24910"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""CPD-24910\""]/inchi""}, {""reference_id"": ""CHEBI:176581"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:176581\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:176581"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI L-lysyl-5'-AMP(1+)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:CPD-24910"", ""source_sha256"": ""67d0129470b9ffcf8b9991426121f50da7feafc7381e62f804421932ca63c144"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native CPD-24910"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPD-24910""}, {""id"": ""MetaCyc:RXN-22679"", ""source_sha256"": ""02dff777c34ed90d031dc418c88070660ec60ba79055f76b1f3e1718524ee36e"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-22679"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-22679""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-024_701a22d1bfbd	MetaCyc:RXN-22679	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:33019|MetaCyc:PPI|MetaCyc:RXN-22679	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-22679"", ""source_assertion"": ""The original right side contains PPI with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-22679\""]/right[*[@frameid=\""PPI\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:PPI"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""PPI\""]/inchi""}, {""reference_id"": ""CHEBI:33019"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:33019\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:33019"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI diphosphate(3-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:PPI"", ""source_sha256"": ""f05985a2eb421b0377d549dff696bd292908326a80e6f19b18a45a54bac40290"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PPI"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PPI""}, {""id"": ""MetaCyc:RXN-22679"", ""source_sha256"": ""02dff777c34ed90d031dc418c88070660ec60ba79055f76b1f3e1718524ee36e"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-22679"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-22679""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-025_3cc18dd31f27	CHEBI:176581	pathwaymech:consumes	MetaCyc:RXN-23308	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:176581|MetaCyc:CPD-24910|MetaCyc:RXN-23308	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-23308"", ""source_assertion"": ""The original left side contains CPD-24910 with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23308\""]/left[*[@frameid=\""CPD-24910\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-24910"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""CPD-24910\""]/inchi""}, {""reference_id"": ""CHEBI:176581"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:176581\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:176581"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI L-lysyl-5'-AMP(1+)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:CPD-24910"", ""source_sha256"": ""67d0129470b9ffcf8b9991426121f50da7feafc7381e62f804421932ca63c144"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native CPD-24910"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPD-24910""}, {""id"": ""MetaCyc:RXN-23308"", ""source_sha256"": ""f6df3f410be328f11f9e88ca965ae746be735054fea2438ba267b7effd9986ea"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23308"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23308""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-026_25b1df1380b0	MetaCyc:MxcG	pathwaymech:consumes	MetaCyc:RXN-23308	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:MxcG|MetaCyc:RXN-23308	Coefficient: 1. Whole carrier reactive class, not a free acyl group or a fixed number of native protein molecules.	"[{""reference_id"": ""MetaCyc:RXN-23308"", ""source_assertion"": ""The original left side contains MxcG with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23308\""]/left[*[@frameid=\""MxcG\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:MxcG"", ""source_assertion"": ""The original typed Protein class names this whole Mxc carrier reactive state. It does not supply a full molecular formula, engineered construct sequence or measured assembly stoichiometry."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""MxcG\""]/common-name""}]"	"[{""id"": ""MetaCyc:MxcG"", ""source_sha256"": ""5a4ff2e74291faecb0786e2e9a0ea96c1803a2a408a2cfed33009144c11f92c6"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native MxcG"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:MxcG""}, {""id"": ""MetaCyc:RXN-23308"", ""source_sha256"": ""f6df3f410be328f11f9e88ca965ae746be735054fea2438ba267b7effd9986ea"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23308"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23308""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-027_26b125a738a6	MetaCyc:RXN-23308	pathwaymech:produces	MetaCyc:Lysyl-MxcG	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Lysyl-MxcG|MetaCyc:RXN-23308	Coefficient: 1. Whole carrier reactive class, not a free acyl group or a fixed number of native protein molecules.	"[{""reference_id"": ""MetaCyc:RXN-23308"", ""source_assertion"": ""The original right side contains Lysyl-MxcG with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23308\""]/right[*[@frameid=\""Lysyl-MxcG\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:Lysyl-MxcG"", ""source_assertion"": ""The original typed Protein class names this whole Mxc carrier reactive state. It does not supply a full molecular formula, engineered construct sequence or measured assembly stoichiometry."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""Lysyl-MxcG\""]/common-name""}]"	"[{""id"": ""MetaCyc:Lysyl-MxcG"", ""source_sha256"": ""af2137d7749d50bae5358ab332b97b5e7ebf76787a7a8e7d06fd198462e9a4f0"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native Lysyl-MxcG"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:Lysyl-MxcG""}, {""id"": ""MetaCyc:RXN-23308"", ""source_sha256"": ""f6df3f410be328f11f9e88ca965ae746be735054fea2438ba267b7effd9986ea"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23308"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23308""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-028_67f7afc05e57	MetaCyc:RXN-23308	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:456215|MetaCyc:AMP|MetaCyc:RXN-23308	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-23308"", ""source_assertion"": ""The original right side contains AMP with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23308\""]/right[*[@frameid=\""AMP\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:AMP"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""AMP\""]/inchi""}, {""reference_id"": ""CHEBI:456215"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:456215\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:456215"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI adenosine 5'-monophosphate(2-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:AMP"", ""source_sha256"": ""d9ff83dc0e72ac41b27ef552592c61a8f682c26fb131a127789d3093f5614286"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native AMP"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:AMP""}, {""id"": ""MetaCyc:RXN-23308"", ""source_sha256"": ""f6df3f410be328f11f9e88ca965ae746be735054fea2438ba267b7effd9986ea"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23308"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23308""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-029_ea4d4bb26e37	MetaCyc:RXN-23308	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-23308	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-23308"", ""source_assertion"": ""The original right side contains PROTON with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23308\""]/right[*[@frameid=\""PROTON\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""PROTON\""]/inchi""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:15378\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI hydron"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""22115ac465b8f70fb4d34d11e93120cafb805cbc00c2391f21a5a27f1563602f"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PROTON"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PROTON""}, {""id"": ""MetaCyc:RXN-23308"", ""source_sha256"": ""f6df3f410be328f11f9e88ca965ae746be735054fea2438ba267b7effd9986ea"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23308"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23308""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-030_60862509990e	MetaCyc:23-DHB-MxcF	pathwaymech:consumes	MetaCyc:RXN-23316	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:23-DHB-MxcF|MetaCyc:RXN-23316|PMID:11562468	Coefficient: 1. Whole carrier reactive class, not a free acyl group or a fixed number of native protein molecules. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""MetaCyc:RXN-23316"", ""source_assertion"": ""The original left side contains 23-DHB-MxcF with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23316\""]/left[*[@frameid=\""23-DHB-MxcF\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:23-DHB-MxcF"", ""source_assertion"": ""The original typed Protein class names this whole Mxc carrier reactive state. It does not supply a full molecular formula, engineered construct sequence or measured assembly stoichiometry."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""23-DHB-MxcF\""]/common-name""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""MetaCyc:23-DHB-MxcF"", ""source_sha256"": ""7510aefad9ea7dc25a28574c4fd68cffb52ef611d3c3e413a62867e52359b12e"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native 23-DHB-MxcF"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:23-DHB-MxcF""}, {""id"": ""MetaCyc:RXN-23316"", ""source_sha256"": ""1d524ccbb2d2d749e3398e2b829ca4484340786e29d038f36d46f7837fd4fe23"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23316"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23316""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-031_791fa2e9a5fe	MetaCyc:Lysyl-MxcG	pathwaymech:consumes	MetaCyc:RXN-23316	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Lysyl-MxcG|MetaCyc:RXN-23316|PMID:11562468	Coefficient: 1. Whole carrier reactive class, not a free acyl group or a fixed number of native protein molecules. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""MetaCyc:RXN-23316"", ""source_assertion"": ""The original left side contains Lysyl-MxcG with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23316\""]/left[*[@frameid=\""Lysyl-MxcG\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:Lysyl-MxcG"", ""source_assertion"": ""The original typed Protein class names this whole Mxc carrier reactive state. It does not supply a full molecular formula, engineered construct sequence or measured assembly stoichiometry."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""Lysyl-MxcG\""]/common-name""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""MetaCyc:Lysyl-MxcG"", ""source_sha256"": ""af2137d7749d50bae5358ab332b97b5e7ebf76787a7a8e7d06fd198462e9a4f0"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native Lysyl-MxcG"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:Lysyl-MxcG""}, {""id"": ""MetaCyc:RXN-23316"", ""source_sha256"": ""1d524ccbb2d2d749e3398e2b829ca4484340786e29d038f36d46f7837fd4fe23"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23316"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23316""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-032_4dd0234b1da6	MetaCyc:RXN-23316	pathwaymech:produces	MetaCyc:N-23-DHB-Lysyl-MxcG	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:N-23-DHB-Lysyl-MxcG|MetaCyc:RXN-23316|PMID:11562468	Coefficient: 1. Whole carrier reactive class, not a free acyl group or a fixed number of native protein molecules. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""MetaCyc:RXN-23316"", ""source_assertion"": ""The original right side contains N-23-DHB-Lysyl-MxcG with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23316\""]/right[*[@frameid=\""N-23-DHB-Lysyl-MxcG\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:N-23-DHB-Lysyl-MxcG"", ""source_assertion"": ""The original typed Protein class names this whole Mxc carrier reactive state. It does not supply a full molecular formula, engineered construct sequence or measured assembly stoichiometry."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""N-23-DHB-Lysyl-MxcG\""]/common-name""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""MetaCyc:N-23-DHB-Lysyl-MxcG"", ""source_sha256"": ""d3241e22ed8ce56bcb86cb2c63ca629544dc995ed1bc189836f41d6b8b83d5ac"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native N-23-DHB-Lysyl-MxcG"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:N-23-DHB-Lysyl-MxcG""}, {""id"": ""MetaCyc:RXN-23316"", ""source_sha256"": ""1d524ccbb2d2d749e3398e2b829ca4484340786e29d038f36d46f7837fd4fe23"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23316"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23316""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-033_b4cfc90a32ea	MetaCyc:RXN-23316	pathwaymech:produces	MetaCyc:MxcF	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:MxcF|MetaCyc:RXN-23316|PMID:11562468	Coefficient: 1. Whole carrier reactive class, not a free acyl group or a fixed number of native protein molecules. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""MetaCyc:RXN-23316"", ""source_assertion"": ""The original right side contains MxcF with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23316\""]/right[*[@frameid=\""MxcF\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:MxcF"", ""source_assertion"": ""The original typed Protein class names this whole Mxc carrier reactive state. It does not supply a full molecular formula, engineered construct sequence or measured assembly stoichiometry."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""MxcF\""]/common-name""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""MetaCyc:MxcF"", ""source_sha256"": ""166fc987341594d992c90774a2aa486355e901cbb63b6bdb1c21759f69babe9c"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native MxcF"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:MxcF""}, {""id"": ""MetaCyc:RXN-23316"", ""source_sha256"": ""1d524ccbb2d2d749e3398e2b829ca4484340786e29d038f36d46f7837fd4fe23"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23316"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23316""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-034_92cb945e68c6	MetaCyc:RXN-23316	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-23316|PMID:11562468	Coefficient: 1. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""MetaCyc:RXN-23316"", ""source_assertion"": ""The original right side contains PROTON with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23316\""]/right[*[@frameid=\""PROTON\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""PROTON\""]/inchi""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:15378\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI hydron"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""22115ac465b8f70fb4d34d11e93120cafb805cbc00c2391f21a5a27f1563602f"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PROTON"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PROTON""}, {""id"": ""MetaCyc:RXN-23316"", ""source_sha256"": ""1d524ccbb2d2d749e3398e2b829ca4484340786e29d038f36d46f7837fd4fe23"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23316"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23316""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-035_7504ffda6777	MetaCyc:23-DHB-MxcF	pathwaymech:consumes	MetaCyc:RXN-23312	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:23-DHB-MxcF|MetaCyc:RXN-23312|PMID:11562468	Coefficient: 1. Whole carrier reactive class, not a free acyl group or a fixed number of native protein molecules. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""MetaCyc:RXN-23312"", ""source_assertion"": ""The original left side contains 23-DHB-MxcF with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23312\""]/left[*[@frameid=\""23-DHB-MxcF\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:23-DHB-MxcF"", ""source_assertion"": ""The original typed Protein class names this whole Mxc carrier reactive state. It does not supply a full molecular formula, engineered construct sequence or measured assembly stoichiometry."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""23-DHB-MxcF\""]/common-name""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""MetaCyc:23-DHB-MxcF"", ""source_sha256"": ""7510aefad9ea7dc25a28574c4fd68cffb52ef611d3c3e413a62867e52359b12e"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native 23-DHB-MxcF"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:23-DHB-MxcF""}, {""id"": ""MetaCyc:RXN-23312"", ""source_sha256"": ""9e135b1f855f618eb0a32e00edc968a94fc01505061b090d1d5f0591e7649c01"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23312"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23312""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-036_d6afa6fb7d53	MetaCyc:N-23-DHB-Lysyl-MxcG	pathwaymech:consumes	MetaCyc:RXN-23312	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:N-23-DHB-Lysyl-MxcG|MetaCyc:RXN-23312|PMID:11562468	Coefficient: 1. Whole carrier reactive class, not a free acyl group or a fixed number of native protein molecules. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""MetaCyc:RXN-23312"", ""source_assertion"": ""The original left side contains N-23-DHB-Lysyl-MxcG with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23312\""]/left[*[@frameid=\""N-23-DHB-Lysyl-MxcG\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:N-23-DHB-Lysyl-MxcG"", ""source_assertion"": ""The original typed Protein class names this whole Mxc carrier reactive state. It does not supply a full molecular formula, engineered construct sequence or measured assembly stoichiometry."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""N-23-DHB-Lysyl-MxcG\""]/common-name""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""MetaCyc:N-23-DHB-Lysyl-MxcG"", ""source_sha256"": ""d3241e22ed8ce56bcb86cb2c63ca629544dc995ed1bc189836f41d6b8b83d5ac"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native N-23-DHB-Lysyl-MxcG"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:N-23-DHB-Lysyl-MxcG""}, {""id"": ""MetaCyc:RXN-23312"", ""source_sha256"": ""9e135b1f855f618eb0a32e00edc968a94fc01505061b090d1d5f0591e7649c01"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23312"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23312""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-037_25792bb3ed73	MetaCyc:RXN-23312	pathwaymech:produces	MetaCyc:N-N-di23-DHB-Lysyl-MxcG	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:N-N-di23-DHB-Lysyl-MxcG|MetaCyc:RXN-23312|PMID:11562468	Coefficient: 1. Whole carrier reactive class, not a free acyl group or a fixed number of native protein molecules. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""MetaCyc:RXN-23312"", ""source_assertion"": ""The original right side contains N-N-di23-DHB-Lysyl-MxcG with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23312\""]/right[*[@frameid=\""N-N-di23-DHB-Lysyl-MxcG\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:N-N-di23-DHB-Lysyl-MxcG"", ""source_assertion"": ""The original typed Protein class names this whole Mxc carrier reactive state. It does not supply a full molecular formula, engineered construct sequence or measured assembly stoichiometry."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""N-N-di23-DHB-Lysyl-MxcG\""]/common-name""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""MetaCyc:N-N-di23-DHB-Lysyl-MxcG"", ""source_sha256"": ""9d2e32df193e97fff79dfb6307352426fc7d7658d593241478f9888d0858988c"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native N-N-di23-DHB-Lysyl-MxcG"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:N-N-di23-DHB-Lysyl-MxcG""}, {""id"": ""MetaCyc:RXN-23312"", ""source_sha256"": ""9e135b1f855f618eb0a32e00edc968a94fc01505061b090d1d5f0591e7649c01"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23312"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23312""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-038_71945b46d402	MetaCyc:RXN-23312	pathwaymech:produces	MetaCyc:MxcF	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:MxcF|MetaCyc:RXN-23312|PMID:11562468	Coefficient: 1. Whole carrier reactive class, not a free acyl group or a fixed number of native protein molecules. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""MetaCyc:RXN-23312"", ""source_assertion"": ""The original right side contains MxcF with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23312\""]/right[*[@frameid=\""MxcF\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:MxcF"", ""source_assertion"": ""The original typed Protein class names this whole Mxc carrier reactive state. It does not supply a full molecular formula, engineered construct sequence or measured assembly stoichiometry."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""MxcF\""]/common-name""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""MetaCyc:MxcF"", ""source_sha256"": ""166fc987341594d992c90774a2aa486355e901cbb63b6bdb1c21759f69babe9c"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native MxcF"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:MxcF""}, {""id"": ""MetaCyc:RXN-23312"", ""source_sha256"": ""9e135b1f855f618eb0a32e00edc968a94fc01505061b090d1d5f0591e7649c01"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23312"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23312""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-039_71e350ab4b26	MetaCyc:RXN-23312	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-23312|PMID:11562468	Coefficient: 1. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""MetaCyc:RXN-23312"", ""source_assertion"": ""The original right side contains PROTON with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23312\""]/right[*[@frameid=\""PROTON\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""PROTON\""]/inchi""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:15378\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI hydron"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""22115ac465b8f70fb4d34d11e93120cafb805cbc00c2391f21a5a27f1563602f"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PROTON"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PROTON""}, {""id"": ""MetaCyc:RXN-23312"", ""source_sha256"": ""9e135b1f855f618eb0a32e00edc968a94fc01505061b090d1d5f0591e7649c01"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23312"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23312""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-040_e2b65d226b06	MetaCyc:N-N-di23-DHB-Lysyl-MxcG	pathwaymech:consumes	MetaCyc:RXN-23313	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:N-N-di23-DHB-Lysyl-MxcG|MetaCyc:RXN-23313	Coefficient: 1. Whole carrier reactive class, not a free acyl group or a fixed number of native protein molecules.	"[{""reference_id"": ""MetaCyc:RXN-23313"", ""source_assertion"": ""The original left side contains N-N-di23-DHB-Lysyl-MxcG with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23313\""]/left[*[@frameid=\""N-N-di23-DHB-Lysyl-MxcG\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:N-N-di23-DHB-Lysyl-MxcG"", ""source_assertion"": ""The original typed Protein class names this whole Mxc carrier reactive state. It does not supply a full molecular formula, engineered construct sequence or measured assembly stoichiometry."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""N-N-di23-DHB-Lysyl-MxcG\""]/common-name""}]"	"[{""id"": ""MetaCyc:N-N-di23-DHB-Lysyl-MxcG"", ""source_sha256"": ""9d2e32df193e97fff79dfb6307352426fc7d7658d593241478f9888d0858988c"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native N-N-di23-DHB-Lysyl-MxcG"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:N-N-di23-DHB-Lysyl-MxcG""}, {""id"": ""MetaCyc:RXN-23313"", ""source_sha256"": ""58ee147cf9663d49a8983e20634258902792c8538013c634d932ea87b2ede4c3"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23313"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23313""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-041_b62c893edf13	CHEBI:57783	pathwaymech:consumes	MetaCyc:RXN-23313	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:57783|MetaCyc:NADPH|MetaCyc:RXN-23313	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-23313"", ""source_assertion"": ""The original left side contains NADPH with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23313\""]/left[*[@frameid=\""NADPH\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:NADPH"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""NADPH\""]/inchi""}, {""reference_id"": ""CHEBI:57783"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:57783\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:57783"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI NADPH(4-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:NADPH"", ""source_sha256"": ""8825cd892778e531c881eb5fce5315e076547885e450dfed924bd38fab3fe9fc"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native NADPH"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NADPH""}, {""id"": ""MetaCyc:RXN-23313"", ""source_sha256"": ""58ee147cf9663d49a8983e20634258902792c8538013c634d932ea87b2ede4c3"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23313"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23313""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-042_7ea2fe283a1e	CHEBI:15378	pathwaymech:consumes	MetaCyc:RXN-23313	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-23313	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-23313"", ""source_assertion"": ""The original left side contains PROTON with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23313\""]/left[*[@frameid=\""PROTON\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""PROTON\""]/inchi""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:15378\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI hydron"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""22115ac465b8f70fb4d34d11e93120cafb805cbc00c2391f21a5a27f1563602f"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PROTON"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PROTON""}, {""id"": ""MetaCyc:RXN-23313"", ""source_sha256"": ""58ee147cf9663d49a8983e20634258902792c8538013c634d932ea87b2ede4c3"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23313"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23313""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-043_6f59bef67763	MetaCyc:RXN-23313	pathwaymech:produces	MetaCyc:CPD-25916	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-25916|MetaCyc:RXN-23313	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-23313"", ""source_assertion"": ""The original right side contains CPD-25916 with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23313\""]/right[*[@frameid=\""CPD-25916\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-25916"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""CPD-25916\""]/inchi""}]"	"[{""id"": ""MetaCyc:CPD-25916"", ""source_sha256"": ""5b0c288fedef5f2c616d77a2bab4b60707d8fa132970044d997013283dbd6fff"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native CPD-25916"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPD-25916""}, {""id"": ""MetaCyc:RXN-23313"", ""source_sha256"": ""58ee147cf9663d49a8983e20634258902792c8538013c634d932ea87b2ede4c3"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23313"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23313""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-044_def96d4326f7	MetaCyc:RXN-23313	pathwaymech:produces	MetaCyc:MxcG	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:MxcG|MetaCyc:RXN-23313	Coefficient: 1. Whole carrier reactive class, not a free acyl group or a fixed number of native protein molecules.	"[{""reference_id"": ""MetaCyc:RXN-23313"", ""source_assertion"": ""The original right side contains MxcG with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23313\""]/right[*[@frameid=\""MxcG\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:MxcG"", ""source_assertion"": ""The original typed Protein class names this whole Mxc carrier reactive state. It does not supply a full molecular formula, engineered construct sequence or measured assembly stoichiometry."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""MxcG\""]/common-name""}]"	"[{""id"": ""MetaCyc:MxcG"", ""source_sha256"": ""5a4ff2e74291faecb0786e2e9a0ea96c1803a2a408a2cfed33009144c11f92c6"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native MxcG"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:MxcG""}, {""id"": ""MetaCyc:RXN-23313"", ""source_sha256"": ""58ee147cf9663d49a8983e20634258902792c8538013c634d932ea87b2ede4c3"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23313"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23313""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-045_d046a56b5fd8	MetaCyc:RXN-23313	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:58349|MetaCyc:NADP|MetaCyc:RXN-23313	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-23313"", ""source_assertion"": ""The original right side contains NADP with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23313\""]/right[*[@frameid=\""NADP\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:NADP"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""NADP\""]/inchi""}, {""reference_id"": ""CHEBI:58349"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:58349\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:58349"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI NADP(3-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:NADP"", ""source_sha256"": ""df6f036b713aaa8dfdf09651eb39b8ce3f7e06e380740c226883065f49a571a7"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native NADP"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NADP""}, {""id"": ""MetaCyc:RXN-23313"", ""source_sha256"": ""58ee147cf9663d49a8983e20634258902792c8538013c634d932ea87b2ede4c3"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23313"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23313""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-046_603e7ad333fd	MetaCyc:CPD-25916	pathwaymech:consumes	MetaCyc:RXN-23314	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-25916|MetaCyc:RXN-23314	Coefficient: 1.  Native right-to-left flux reduces the aldehyde; the printed left side is the oxidation product side.	"[{""reference_id"": ""MetaCyc:RXN-23314"", ""source_assertion"": ""The original right side contains CPD-25916 with coefficient 1; native direction is PHYSIOL-RIGHT-TO-LEFT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23314\""]/right[*[@frameid=\""CPD-25916\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-25916"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""CPD-25916\""]/inchi""}]"	"[{""id"": ""MetaCyc:CPD-25916"", ""source_sha256"": ""5b0c288fedef5f2c616d77a2bab4b60707d8fa132970044d997013283dbd6fff"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native CPD-25916"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPD-25916""}, {""id"": ""MetaCyc:RXN-23314"", ""source_sha256"": ""64acdd14d9e27fda70747a5cd18ff67b83b034022dbb544de0ee560f7e5454e9"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23314"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23314""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-047_859bdd0d6c19	CHEBI:57783	pathwaymech:consumes	MetaCyc:RXN-23314	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:57783|MetaCyc:NADPH|MetaCyc:RXN-23314	Coefficient: 1.  Native right-to-left flux reduces the aldehyde; the printed left side is the oxidation product side.	"[{""reference_id"": ""MetaCyc:RXN-23314"", ""source_assertion"": ""The original right side contains NADPH with coefficient 1; native direction is PHYSIOL-RIGHT-TO-LEFT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23314\""]/right[*[@frameid=\""NADPH\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:NADPH"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""NADPH\""]/inchi""}, {""reference_id"": ""CHEBI:57783"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:57783\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:57783"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI NADPH(4-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:NADPH"", ""source_sha256"": ""8825cd892778e531c881eb5fce5315e076547885e450dfed924bd38fab3fe9fc"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native NADPH"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NADPH""}, {""id"": ""MetaCyc:RXN-23314"", ""source_sha256"": ""64acdd14d9e27fda70747a5cd18ff67b83b034022dbb544de0ee560f7e5454e9"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23314"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23314""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-048_c1b1bb5fccf7	CHEBI:15378	pathwaymech:consumes	MetaCyc:RXN-23314	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-23314	Coefficient: 1.  Native right-to-left flux reduces the aldehyde; the printed left side is the oxidation product side.	"[{""reference_id"": ""MetaCyc:RXN-23314"", ""source_assertion"": ""The original right side contains PROTON with coefficient 1; native direction is PHYSIOL-RIGHT-TO-LEFT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23314\""]/right[*[@frameid=\""PROTON\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""PROTON\""]/inchi""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:15378\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI hydron"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""22115ac465b8f70fb4d34d11e93120cafb805cbc00c2391f21a5a27f1563602f"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PROTON"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PROTON""}, {""id"": ""MetaCyc:RXN-23314"", ""source_sha256"": ""64acdd14d9e27fda70747a5cd18ff67b83b034022dbb544de0ee560f7e5454e9"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23314"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23314""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-049_bec3ae9bf031	MetaCyc:RXN-23314	pathwaymech:produces	MetaCyc:CPD-25904	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-25904|MetaCyc:RXN-23314	Coefficient: 1. The exact native stereospecific product is retained; stereounspecified CHEBI:31877 is not an exact mapping. Native right-to-left flux reduces the aldehyde; the printed left side is the oxidation product side.	"[{""reference_id"": ""MetaCyc:RXN-23314"", ""source_assertion"": ""The original left side contains CPD-25904 with coefficient 1; native direction is PHYSIOL-RIGHT-TO-LEFT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23314\""]/left[*[@frameid=\""CPD-25904\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-25904"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""CPD-25904\""]/inchi""}]"	"[{""id"": ""MetaCyc:CPD-25904"", ""source_sha256"": ""80882b924222997f49d0e442444c98f09db110334bdd33aaac25419b81bffaa1"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native CPD-25904"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPD-25904""}, {""id"": ""MetaCyc:RXN-23314"", ""source_sha256"": ""64acdd14d9e27fda70747a5cd18ff67b83b034022dbb544de0ee560f7e5454e9"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23314"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23314""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-050_8af691504ca3	MetaCyc:RXN-23314	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:58349|MetaCyc:NADP|MetaCyc:RXN-23314	Coefficient: 1.  Native right-to-left flux reduces the aldehyde; the printed left side is the oxidation product side.	"[{""reference_id"": ""MetaCyc:RXN-23314"", ""source_assertion"": ""The original left side contains NADP with coefficient 1; native direction is PHYSIOL-RIGHT-TO-LEFT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23314\""]/left[*[@frameid=\""NADP\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:NADP"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""NADP\""]/inchi""}, {""reference_id"": ""CHEBI:58349"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:58349\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:58349"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI NADP(3-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:NADP"", ""source_sha256"": ""df6f036b713aaa8dfdf09651eb39b8ce3f7e06e380740c226883065f49a571a7"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native NADP"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NADP""}, {""id"": ""MetaCyc:RXN-23314"", ""source_sha256"": ""64acdd14d9e27fda70747a5cd18ff67b83b034022dbb544de0ee560f7e5454e9"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23314"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23314""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-051_a9f284c7a84a	MetaCyc:CPD-25916	pathwaymech:consumes	MetaCyc:RXN-23315	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-25916|MetaCyc:RXN-23315	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-23315"", ""source_assertion"": ""The original left side contains CPD-25916 with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23315\""]/left[*[@frameid=\""CPD-25916\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-25916"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""CPD-25916\""]/inchi""}]"	"[{""id"": ""MetaCyc:CPD-25916"", ""source_sha256"": ""5b0c288fedef5f2c616d77a2bab4b60707d8fa132970044d997013283dbd6fff"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native CPD-25916"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPD-25916""}, {""id"": ""MetaCyc:RXN-23315"", ""source_sha256"": ""1a6b7e23e6fc72435bc79bfa4f9b004a880545d4cba1f85c1da9bfe9333fe7a7"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23315"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23315""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-052_7fb4dbf25788	CHEBI:29985	pathwaymech:consumes	MetaCyc:RXN-23315	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:29985|MetaCyc:GLT|MetaCyc:RXN-23315	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-23315"", ""source_assertion"": ""The original left side contains GLT with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23315\""]/left[*[@frameid=\""GLT\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:GLT"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""GLT\""]/inchi""}, {""reference_id"": ""CHEBI:29985"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:29985\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:29985"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI L-glutamate(1-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:GLT"", ""source_sha256"": ""e29868a0fcf6892d361d7ba708065c0f5df20c7c028674274920010d4729a533"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native GLT"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:GLT""}, {""id"": ""MetaCyc:RXN-23315"", ""source_sha256"": ""1a6b7e23e6fc72435bc79bfa4f9b004a880545d4cba1f85c1da9bfe9333fe7a7"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23315"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23315""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-053_769adc9137ea	MetaCyc:RXN-23315	pathwaymech:produces	CHEBI:7061	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:7061|MetaCyc:CPD-25905|MetaCyc:RXN-23315	Coefficient: 1. CHEBI:7061 full structural identity is used; its inconsistent hydroxy/reduction definition is excluded.	"[{""reference_id"": ""MetaCyc:RXN-23315"", ""source_assertion"": ""The original right side contains CPD-25905 with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23315\""]/right[*[@frameid=\""CPD-25905\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-25905"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""CPD-25905\""]/inchi""}, {""reference_id"": ""CHEBI:7061"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:7061\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:7061"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI myxochelin B"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:CPD-25905"", ""source_sha256"": ""1e631282961ef9c52120a78201db4b5014896578c5a51c18c01a578d5a8ade3a"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native CPD-25905"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:CPD-25905""}, {""id"": ""MetaCyc:RXN-23315"", ""source_sha256"": ""1a6b7e23e6fc72435bc79bfa4f9b004a880545d4cba1f85c1da9bfe9333fe7a7"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23315"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23315""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-054_cb3f9b84dfd5	MetaCyc:RXN-23315	pathwaymech:produces	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:16810|MetaCyc:2-KETOGLUTARATE|MetaCyc:RXN-23315	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-23315"", ""source_assertion"": ""The original right side contains 2-KETOGLUTARATE with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23315\""]/right[*[@frameid=\""2-KETOGLUTARATE\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:2-KETOGLUTARATE"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""2-KETOGLUTARATE\""]/inchi""}, {""reference_id"": ""CHEBI:16810"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:16810\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:16810"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI 2-oxoglutarate(2-)"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:2-KETOGLUTARATE"", ""source_sha256"": ""23246fa1176f753df61d4d23211e7a177f0929c80c17afa03a7f8398732c2f6a"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native 2-KETOGLUTARATE"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:2-KETOGLUTARATE""}, {""id"": ""MetaCyc:RXN-23315"", ""source_sha256"": ""1a6b7e23e6fc72435bc79bfa4f9b004a880545d4cba1f85c1da9bfe9333fe7a7"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23315"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23315""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-055_9a3b70ced9fa	MetaCyc:RXN-23315	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-23315	Coefficient: 1.	"[{""reference_id"": ""MetaCyc:RXN-23315"", ""source_assertion"": ""The original right side contains PROTON with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23315\""]/right[*[@frameid=\""PROTON\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native compound supplies its explicit Standard InChI, fixing the source chemical structure and protonation used in this equation."", ""source_locator"": ""/ptools-xml/Compound[@frameid=\""PROTON\""]/inchi""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""The issuing ChEBI Standard InChI exactly matches the native compound, including stated stereochemistry and protonation. The identifier is selected by structure; descriptive definitions are not biochemical evidence."", ""source_locator"": ""statements WHERE subject=\""CHEBI:15378\"" AND predicate IN (\""rdfs:label\"",\""chemrof:inchi_string\"",\""chemrof:generalized_empirical_formula\"",\""chemrof:charge\"")""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; hash covers original complete uncompressed Semantic SQL database"", ""title"": ""ChEBI hydron"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""22115ac465b8f70fb4d34d11e93120cafb805cbc00c2391f21a5a27f1563602f"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native PROTON"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PROTON""}, {""id"": ""MetaCyc:RXN-23315"", ""source_sha256"": ""1a6b7e23e6fc72435bc79bfa4f9b004a880545d4cba1f85c1da9bfe9333fe7a7"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23315"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23315""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-056_395f47adff07	UniProtKB:Q9F638	pathwaymech:enables	MetaCyc:DHBAMPLIG-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:MONOMER-124161|NCBIProtein:AAG31128.1|PMID:11562468|UniProtKB:Q9F638	Native gene-product/activity relation supported by source annotation and qualified recombinant reconstitution. No fixed E:F:G:L assembly is asserted.	"[{""reference_id"": ""NCBIProtein:AAG31128.1"", ""source_assertion"": ""The mxcE CDS in AF299336.1 supplies AAG31128.1, 543 residues, from Sg a15. Its native translation is exactly identical to the selected UniProt sequence; engineered tags and processing are separate."", ""source_locator"": ""//GBFeature[GBFeature_key=\""CDS\""][GBFeature_quals/GBQualifier[GBQualifier_name=\""gene\""]/GBQualifier_value=\""mxcE\""]/GBFeature_quals; //GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}, {""reference_id"": ""UniProtKB:Q9F638"", ""source_assertion"": ""The entry provides the selected full native sequence and versioned EMBL protein cross-reference. This unreviewed species-level annotation is not itself an experimental assay."", ""source_locator"": ""/primaryAccession; /sequence; /uniProtKBCrossReferences; /entryType; /organism""}, {""reference_id"": ""MetaCyc:MONOMER-124161"", ""source_assertion"": ""The MxcE source object links Q9F638/AAG31128.1 and its composite DHB activation/loading activity RXN-23311. It is the myxochelin controller; the VibE controller of shared DHBAMPLIG-RXN is not transferred."", ""source_locator"": ""/ptools-xml/Protein/catalyzes/Enzymatic-Reaction/reaction; /ptools-xml/Protein/dblink""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Discussion assigns DHB adenylation and loading onto the MxcF aryl-carrier domain to MxcE. The primary E/F/G reconstitution confirms pathway activity, rather than separately measuring each native half-reaction."", ""source_locator"": ""//*[@id=\""sec11\""]/p[5]; //*[@id=\""sec9\""]/p[1]""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""E/F/G genes were amplified from Sg a15 DNA using AF299336 primers. Intein-chitin constructs carry C-terminal extensions; purification and processing distinguish assayed proteins from exact bare native sequences."", ""source_locator"": ""//*[@id=\""sec2\""]/p[1]; //*[@id=\""sec3\""]/p[1]""}]"	"[{""id"": ""MetaCyc:MONOMER-124161"", ""source_sha256"": ""112efb20fdfb4144cf132820d6b8c69507fcd8439ba956b68490dc9c242d5f12"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native MONOMER-124161"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:MONOMER-124161""}, {""id"": ""NCBIProtein:AAG31128.1"", ""source_sha256"": ""e9ef9bc9825dda8aa6e027cc381faf09a287571ebdff2f582a143a7797226ed6"", ""source_version"": ""Original versioned AF299336.1 GenBank XML; reference digest covers whole nucleotide record, exact CDS qualifier selected"", ""title"": ""AAG31128.1 mxcE native translation in Sg a15 AF299336.1"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=nuccore&id=AF299336.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}, {""id"": ""UniProtKB:Q9F638"", ""source_sha256"": ""c5f3b2e3c4d3b379a913023df6a1983b31d7ef822093014522ecff0062625228"", ""source_version"": ""Original individual UniProt JSON; unreviewed species-level entry; exact native sequence separately bridged to AF299336.1"", ""title"": ""UniProtKB Q9F638 mxcE"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9F638.json""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-057_1a40b6f85094	UniProtKB:Q9F638	pathwaymech:enables	MetaCyc:RXN-23310	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:MONOMER-124161|NCBIProtein:AAG31128.1|PMID:11562468|UniProtKB:Q9F638	Native gene-product/activity relation supported by source annotation and qualified recombinant reconstitution. No fixed E:F:G:L assembly is asserted.	"[{""reference_id"": ""NCBIProtein:AAG31128.1"", ""source_assertion"": ""The mxcE CDS in AF299336.1 supplies AAG31128.1, 543 residues, from Sg a15. Its native translation is exactly identical to the selected UniProt sequence; engineered tags and processing are separate."", ""source_locator"": ""//GBFeature[GBFeature_key=\""CDS\""][GBFeature_quals/GBQualifier[GBQualifier_name=\""gene\""]/GBQualifier_value=\""mxcE\""]/GBFeature_quals; //GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}, {""reference_id"": ""UniProtKB:Q9F638"", ""source_assertion"": ""The entry provides the selected full native sequence and versioned EMBL protein cross-reference. This unreviewed species-level annotation is not itself an experimental assay."", ""source_locator"": ""/primaryAccession; /sequence; /uniProtKBCrossReferences; /entryType; /organism""}, {""reference_id"": ""MetaCyc:MONOMER-124161"", ""source_assertion"": ""The MxcE source object links Q9F638/AAG31128.1 and its composite DHB activation/loading activity RXN-23311. It is the myxochelin controller; the VibE controller of shared DHBAMPLIG-RXN is not transferred."", ""source_locator"": ""/ptools-xml/Protein/catalyzes/Enzymatic-Reaction/reaction; /ptools-xml/Protein/dblink""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Discussion assigns DHB adenylation and loading onto the MxcF aryl-carrier domain to MxcE. The primary E/F/G reconstitution confirms pathway activity, rather than separately measuring each native half-reaction."", ""source_locator"": ""//*[@id=\""sec11\""]/p[5]; //*[@id=\""sec9\""]/p[1]""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""E/F/G genes were amplified from Sg a15 DNA using AF299336 primers. Intein-chitin constructs carry C-terminal extensions; purification and processing distinguish assayed proteins from exact bare native sequences."", ""source_locator"": ""//*[@id=\""sec2\""]/p[1]; //*[@id=\""sec3\""]/p[1]""}]"	"[{""id"": ""MetaCyc:MONOMER-124161"", ""source_sha256"": ""112efb20fdfb4144cf132820d6b8c69507fcd8439ba956b68490dc9c242d5f12"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native MONOMER-124161"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:MONOMER-124161""}, {""id"": ""NCBIProtein:AAG31128.1"", ""source_sha256"": ""e9ef9bc9825dda8aa6e027cc381faf09a287571ebdff2f582a143a7797226ed6"", ""source_version"": ""Original versioned AF299336.1 GenBank XML; reference digest covers whole nucleotide record, exact CDS qualifier selected"", ""title"": ""AAG31128.1 mxcE native translation in Sg a15 AF299336.1"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=nuccore&id=AF299336.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}, {""id"": ""UniProtKB:Q9F638"", ""source_sha256"": ""c5f3b2e3c4d3b379a913023df6a1983b31d7ef822093014522ecff0062625228"", ""source_version"": ""Original individual UniProt JSON; unreviewed species-level entry; exact native sequence separately bridged to AF299336.1"", ""title"": ""UniProtKB Q9F638 mxcE"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9F638.json""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-058_594d75eb7c48	UniProtKB:Q9F636	pathwaymech:enables	MetaCyc:RXN-22679	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:MONOMER-124162|NCBIProtein:AAG31130.1|PMID:11562468|UniProtKB:Q9F636	Native gene-product/activity relation supported by source annotation and qualified recombinant reconstitution. No fixed E:F:G:L assembly is asserted.	"[{""reference_id"": ""NCBIProtein:AAG31130.1"", ""source_assertion"": ""The mxcG CDS in AF299336.1 supplies AAG31130.1, 1456 residues, from Sg a15. Its native translation is exactly identical to the selected UniProt sequence; engineered tags and processing are separate."", ""source_locator"": ""//GBFeature[GBFeature_key=\""CDS\""][GBFeature_quals/GBQualifier[GBQualifier_name=\""gene\""]/GBQualifier_value=\""mxcG\""]/GBFeature_quals; //GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}, {""reference_id"": ""UniProtKB:Q9F636"", ""source_assertion"": ""The entry provides the selected full native sequence and versioned EMBL protein cross-reference. This unreviewed species-level annotation is not itself an experimental assay."", ""source_locator"": ""/primaryAccession; /sequence; /uniProtKBCrossReferences; /entryType; /organism""}, {""reference_id"": ""MetaCyc:MONOMER-124162"", ""source_assertion"": ""The MxcG object links Q9F636/AAG31130.1 and assigns lysine loading, iterative condensation, carrier reduction and aldehyde reduction to its domains."", ""source_locator"": ""/ptools-xml/Protein/catalyzes; /ptools-xml/Protein/comment; /ptools-xml/Protein/dblink""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""The reconstituted E/F/G preparation forms A. Discussion assigns lysine activation/loading and two condensations to MxcG, and terminal two-stage reduction to its reductase domain. NADH also supports formation more slowly than NADPH."", ""source_locator"": ""//*[@id=\""sec9\""]/p[1]; //*[@id=\""sec11\""]/p[3]; //*[@id=\""sec11\""]/p[5]""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""E/F/G genes were amplified from Sg a15 DNA using AF299336 primers. Intein-chitin constructs carry C-terminal extensions; purification and processing distinguish assayed proteins from exact bare native sequences."", ""source_locator"": ""//*[@id=\""sec2\""]/p[1]; //*[@id=\""sec3\""]/p[1]""}]"	"[{""id"": ""MetaCyc:MONOMER-124162"", ""source_sha256"": ""342f5a8a0da825da6aba706feecff75be81bb2d3518cd834b5811ebb412d8c79"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native MONOMER-124162"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:MONOMER-124162""}, {""id"": ""NCBIProtein:AAG31130.1"", ""source_sha256"": ""e9ef9bc9825dda8aa6e027cc381faf09a287571ebdff2f582a143a7797226ed6"", ""source_version"": ""Original versioned AF299336.1 GenBank XML; reference digest covers whole nucleotide record, exact CDS qualifier selected"", ""title"": ""AAG31130.1 mxcG native translation in Sg a15 AF299336.1"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=nuccore&id=AF299336.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}, {""id"": ""UniProtKB:Q9F636"", ""source_sha256"": ""b2c2489d9c5bf61e4b46b4f8a81a48af8f8dd3024afe7f08970b914de549d215"", ""source_version"": ""Original individual UniProt JSON; unreviewed species-level entry; exact native sequence separately bridged to AF299336.1"", ""title"": ""UniProtKB Q9F636 mxcG"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9F636.json""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-059_77f4fe155688	UniProtKB:Q9F636	pathwaymech:enables	MetaCyc:RXN-23308	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:MONOMER-124162|NCBIProtein:AAG31130.1|PMID:11562468|UniProtKB:Q9F636	Native gene-product/activity relation supported by source annotation and qualified recombinant reconstitution. No fixed E:F:G:L assembly is asserted.	"[{""reference_id"": ""NCBIProtein:AAG31130.1"", ""source_assertion"": ""The mxcG CDS in AF299336.1 supplies AAG31130.1, 1456 residues, from Sg a15. Its native translation is exactly identical to the selected UniProt sequence; engineered tags and processing are separate."", ""source_locator"": ""//GBFeature[GBFeature_key=\""CDS\""][GBFeature_quals/GBQualifier[GBQualifier_name=\""gene\""]/GBQualifier_value=\""mxcG\""]/GBFeature_quals; //GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}, {""reference_id"": ""UniProtKB:Q9F636"", ""source_assertion"": ""The entry provides the selected full native sequence and versioned EMBL protein cross-reference. This unreviewed species-level annotation is not itself an experimental assay."", ""source_locator"": ""/primaryAccession; /sequence; /uniProtKBCrossReferences; /entryType; /organism""}, {""reference_id"": ""MetaCyc:MONOMER-124162"", ""source_assertion"": ""The MxcG object links Q9F636/AAG31130.1 and assigns lysine loading, iterative condensation, carrier reduction and aldehyde reduction to its domains."", ""source_locator"": ""/ptools-xml/Protein/catalyzes; /ptools-xml/Protein/comment; /ptools-xml/Protein/dblink""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""The reconstituted E/F/G preparation forms A. Discussion assigns lysine activation/loading and two condensations to MxcG, and terminal two-stage reduction to its reductase domain. NADH also supports formation more slowly than NADPH."", ""source_locator"": ""//*[@id=\""sec9\""]/p[1]; //*[@id=\""sec11\""]/p[3]; //*[@id=\""sec11\""]/p[5]""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""E/F/G genes were amplified from Sg a15 DNA using AF299336 primers. Intein-chitin constructs carry C-terminal extensions; purification and processing distinguish assayed proteins from exact bare native sequences."", ""source_locator"": ""//*[@id=\""sec2\""]/p[1]; //*[@id=\""sec3\""]/p[1]""}]"	"[{""id"": ""MetaCyc:MONOMER-124162"", ""source_sha256"": ""342f5a8a0da825da6aba706feecff75be81bb2d3518cd834b5811ebb412d8c79"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native MONOMER-124162"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:MONOMER-124162""}, {""id"": ""NCBIProtein:AAG31130.1"", ""source_sha256"": ""e9ef9bc9825dda8aa6e027cc381faf09a287571ebdff2f582a143a7797226ed6"", ""source_version"": ""Original versioned AF299336.1 GenBank XML; reference digest covers whole nucleotide record, exact CDS qualifier selected"", ""title"": ""AAG31130.1 mxcG native translation in Sg a15 AF299336.1"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=nuccore&id=AF299336.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}, {""id"": ""UniProtKB:Q9F636"", ""source_sha256"": ""b2c2489d9c5bf61e4b46b4f8a81a48af8f8dd3024afe7f08970b914de549d215"", ""source_version"": ""Original individual UniProt JSON; unreviewed species-level entry; exact native sequence separately bridged to AF299336.1"", ""title"": ""UniProtKB Q9F636 mxcG"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9F636.json""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-060_8fd267db05ed	UniProtKB:Q9F636	pathwaymech:enables	MetaCyc:RXN-23316	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:MONOMER-124162|NCBIProtein:AAG31130.1|PMID:11562468|UniProtKB:Q9F636	Native gene-product/activity relation supported by source annotation and qualified recombinant reconstitution. No fixed E:F:G:L assembly is asserted. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""NCBIProtein:AAG31130.1"", ""source_assertion"": ""The mxcG CDS in AF299336.1 supplies AAG31130.1, 1456 residues, from Sg a15. Its native translation is exactly identical to the selected UniProt sequence; engineered tags and processing are separate."", ""source_locator"": ""//GBFeature[GBFeature_key=\""CDS\""][GBFeature_quals/GBQualifier[GBQualifier_name=\""gene\""]/GBQualifier_value=\""mxcG\""]/GBFeature_quals; //GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}, {""reference_id"": ""UniProtKB:Q9F636"", ""source_assertion"": ""The entry provides the selected full native sequence and versioned EMBL protein cross-reference. This unreviewed species-level annotation is not itself an experimental assay."", ""source_locator"": ""/primaryAccession; /sequence; /uniProtKBCrossReferences; /entryType; /organism""}, {""reference_id"": ""MetaCyc:MONOMER-124162"", ""source_assertion"": ""The MxcG object links Q9F636/AAG31130.1 and assigns lysine loading, iterative condensation, carrier reduction and aldehyde reduction to its domains."", ""source_locator"": ""/ptools-xml/Protein/catalyzes; /ptools-xml/Protein/comment; /ptools-xml/Protein/dblink""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""The reconstituted E/F/G preparation forms A. Discussion assigns lysine activation/loading and two condensations to MxcG, and terminal two-stage reduction to its reductase domain. NADH also supports formation more slowly than NADPH."", ""source_locator"": ""//*[@id=\""sec9\""]/p[1]; //*[@id=\""sec11\""]/p[3]; //*[@id=\""sec11\""]/p[5]""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""E/F/G genes were amplified from Sg a15 DNA using AF299336 primers. Intein-chitin constructs carry C-terminal extensions; purification and processing distinguish assayed proteins from exact bare native sequences."", ""source_locator"": ""//*[@id=\""sec2\""]/p[1]; //*[@id=\""sec3\""]/p[1]""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""MetaCyc:MONOMER-124162"", ""source_sha256"": ""342f5a8a0da825da6aba706feecff75be81bb2d3518cd834b5811ebb412d8c79"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native MONOMER-124162"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:MONOMER-124162""}, {""id"": ""NCBIProtein:AAG31130.1"", ""source_sha256"": ""e9ef9bc9825dda8aa6e027cc381faf09a287571ebdff2f582a143a7797226ed6"", ""source_version"": ""Original versioned AF299336.1 GenBank XML; reference digest covers whole nucleotide record, exact CDS qualifier selected"", ""title"": ""AAG31130.1 mxcG native translation in Sg a15 AF299336.1"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=nuccore&id=AF299336.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}, {""id"": ""UniProtKB:Q9F636"", ""source_sha256"": ""b2c2489d9c5bf61e4b46b4f8a81a48af8f8dd3024afe7f08970b914de549d215"", ""source_version"": ""Original individual UniProt JSON; unreviewed species-level entry; exact native sequence separately bridged to AF299336.1"", ""title"": ""UniProtKB Q9F636 mxcG"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9F636.json""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-061_ac15e86be6e8	UniProtKB:Q9F636	pathwaymech:enables	MetaCyc:RXN-23312	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:MONOMER-124162|NCBIProtein:AAG31130.1|PMID:11562468|UniProtKB:Q9F636	Native gene-product/activity relation supported by source annotation and qualified recombinant reconstitution. No fixed E:F:G:L assembly is asserted. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""NCBIProtein:AAG31130.1"", ""source_assertion"": ""The mxcG CDS in AF299336.1 supplies AAG31130.1, 1456 residues, from Sg a15. Its native translation is exactly identical to the selected UniProt sequence; engineered tags and processing are separate."", ""source_locator"": ""//GBFeature[GBFeature_key=\""CDS\""][GBFeature_quals/GBQualifier[GBQualifier_name=\""gene\""]/GBQualifier_value=\""mxcG\""]/GBFeature_quals; //GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}, {""reference_id"": ""UniProtKB:Q9F636"", ""source_assertion"": ""The entry provides the selected full native sequence and versioned EMBL protein cross-reference. This unreviewed species-level annotation is not itself an experimental assay."", ""source_locator"": ""/primaryAccession; /sequence; /uniProtKBCrossReferences; /entryType; /organism""}, {""reference_id"": ""MetaCyc:MONOMER-124162"", ""source_assertion"": ""The MxcG object links Q9F636/AAG31130.1 and assigns lysine loading, iterative condensation, carrier reduction and aldehyde reduction to its domains."", ""source_locator"": ""/ptools-xml/Protein/catalyzes; /ptools-xml/Protein/comment; /ptools-xml/Protein/dblink""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""The reconstituted E/F/G preparation forms A. Discussion assigns lysine activation/loading and two condensations to MxcG, and terminal two-stage reduction to its reductase domain. NADH also supports formation more slowly than NADPH."", ""source_locator"": ""//*[@id=\""sec9\""]/p[1]; //*[@id=\""sec11\""]/p[3]; //*[@id=\""sec11\""]/p[5]""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""E/F/G genes were amplified from Sg a15 DNA using AF299336 primers. Intein-chitin constructs carry C-terminal extensions; purification and processing distinguish assayed proteins from exact bare native sequences."", ""source_locator"": ""//*[@id=\""sec2\""]/p[1]; //*[@id=\""sec3\""]/p[1]""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""MetaCyc:MONOMER-124162"", ""source_sha256"": ""342f5a8a0da825da6aba706feecff75be81bb2d3518cd834b5811ebb412d8c79"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native MONOMER-124162"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:MONOMER-124162""}, {""id"": ""NCBIProtein:AAG31130.1"", ""source_sha256"": ""e9ef9bc9825dda8aa6e027cc381faf09a287571ebdff2f582a143a7797226ed6"", ""source_version"": ""Original versioned AF299336.1 GenBank XML; reference digest covers whole nucleotide record, exact CDS qualifier selected"", ""title"": ""AAG31130.1 mxcG native translation in Sg a15 AF299336.1"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=nuccore&id=AF299336.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}, {""id"": ""UniProtKB:Q9F636"", ""source_sha256"": ""b2c2489d9c5bf61e4b46b4f8a81a48af8f8dd3024afe7f08970b914de549d215"", ""source_version"": ""Original individual UniProt JSON; unreviewed species-level entry; exact native sequence separately bridged to AF299336.1"", ""title"": ""UniProtKB Q9F636 mxcG"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9F636.json""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-062_e6f49c1043dc	UniProtKB:Q9F636	pathwaymech:enables	MetaCyc:RXN-23313	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/ja8025278|MetaCyc:MONOMER-124162|NCBIProtein:AAG31130.1|PMID:11562468|UniProtKB:Q9F636	Native gene-product/activity relation supported by source annotation and qualified recombinant reconstitution. No fixed E:F:G:L assembly is asserted.	"[{""reference_id"": ""NCBIProtein:AAG31130.1"", ""source_assertion"": ""The mxcG CDS in AF299336.1 supplies AAG31130.1, 1456 residues, from Sg a15. Its native translation is exactly identical to the selected UniProt sequence; engineered tags and processing are separate."", ""source_locator"": ""//GBFeature[GBFeature_key=\""CDS\""][GBFeature_quals/GBQualifier[GBQualifier_name=\""gene\""]/GBQualifier_value=\""mxcG\""]/GBFeature_quals; //GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}, {""reference_id"": ""UniProtKB:Q9F636"", ""source_assertion"": ""The entry provides the selected full native sequence and versioned EMBL protein cross-reference. This unreviewed species-level annotation is not itself an experimental assay."", ""source_locator"": ""/primaryAccession; /sequence; /uniProtKBCrossReferences; /entryType; /organism""}, {""reference_id"": ""MetaCyc:MONOMER-124162"", ""source_assertion"": ""The MxcG object links Q9F636/AAG31130.1 and assigns lysine loading, iterative condensation, carrier reduction and aldehyde reduction to its domains."", ""source_locator"": ""/ptools-xml/Protein/catalyzes; /ptools-xml/Protein/comment; /ptools-xml/Protein/dblink""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""The reconstituted E/F/G preparation forms A. Discussion assigns lysine activation/loading and two condensations to MxcG, and terminal two-stage reduction to its reductase domain. NADH also supports formation more slowly than NADPH."", ""source_locator"": ""//*[@id=\""sec9\""]/p[1]; //*[@id=\""sec11\""]/p[3]; //*[@id=\""sec11\""]/p[5]""}, {""reference_id"": ""DOI:10.1021/ja8025278"", ""source_assertion"": ""The complete enzyme preparation produces A and B; low amounts of free aldehyde were detected and characterized by LC-MS/MS and PFBHA derivatization."", ""source_locator"": ""S2-S3 Reconstitution in vitro; S3 Detection of the aldehyde intermediate; S4 Figure S-3""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""E/F/G genes were amplified from Sg a15 DNA using AF299336 primers. Intein-chitin constructs carry C-terminal extensions; purification and processing distinguish assayed proteins from exact bare native sequences."", ""source_locator"": ""//*[@id=\""sec2\""]/p[1]; //*[@id=\""sec3\""]/p[1]""}]"	"[{""id"": ""DOI:10.1021/ja8025278"", ""source_sha256"": ""3e242f7d232af6b285fc1bc7b4d97cda4b85a03714332a50437e55917c9238fd"", ""source_version"": ""2008 original official four-page supporting information, DOI-linked ACS Figshare; main body not acquired locally"", ""title"": ""Myxochelin biosynthesis: direct evidence for two- and four-electron reduction of a carrier protein-bound thioester. — Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/4631935""}, {""id"": ""MetaCyc:MONOMER-124162"", ""source_sha256"": ""342f5a8a0da825da6aba706feecff75be81bb2d3518cd834b5811ebb412d8c79"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native MONOMER-124162"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:MONOMER-124162""}, {""id"": ""NCBIProtein:AAG31130.1"", ""source_sha256"": ""e9ef9bc9825dda8aa6e027cc381faf09a287571ebdff2f582a143a7797226ed6"", ""source_version"": ""Original versioned AF299336.1 GenBank XML; reference digest covers whole nucleotide record, exact CDS qualifier selected"", ""title"": ""AAG31130.1 mxcG native translation in Sg a15 AF299336.1"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=nuccore&id=AF299336.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}, {""id"": ""UniProtKB:Q9F636"", ""source_sha256"": ""b2c2489d9c5bf61e4b46b4f8a81a48af8f8dd3024afe7f08970b914de549d215"", ""source_version"": ""Original individual UniProt JSON; unreviewed species-level entry; exact native sequence separately bridged to AF299336.1"", ""title"": ""UniProtKB Q9F636 mxcG"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9F636.json""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-063_6c8528fc4928	UniProtKB:Q9F636	pathwaymech:enables	MetaCyc:RXN-23314	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/ja8025278|MetaCyc:MONOMER-124162|NCBIProtein:AAG31130.1|PMID:11562468|UniProtKB:Q9F636	Native gene-product/activity relation supported by source annotation and qualified recombinant reconstitution. No fixed E:F:G:L assembly is asserted.	"[{""reference_id"": ""NCBIProtein:AAG31130.1"", ""source_assertion"": ""The mxcG CDS in AF299336.1 supplies AAG31130.1, 1456 residues, from Sg a15. Its native translation is exactly identical to the selected UniProt sequence; engineered tags and processing are separate."", ""source_locator"": ""//GBFeature[GBFeature_key=\""CDS\""][GBFeature_quals/GBQualifier[GBQualifier_name=\""gene\""]/GBQualifier_value=\""mxcG\""]/GBFeature_quals; //GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}, {""reference_id"": ""UniProtKB:Q9F636"", ""source_assertion"": ""The entry provides the selected full native sequence and versioned EMBL protein cross-reference. This unreviewed species-level annotation is not itself an experimental assay."", ""source_locator"": ""/primaryAccession; /sequence; /uniProtKBCrossReferences; /entryType; /organism""}, {""reference_id"": ""MetaCyc:MONOMER-124162"", ""source_assertion"": ""The MxcG object links Q9F636/AAG31130.1 and assigns lysine loading, iterative condensation, carrier reduction and aldehyde reduction to its domains."", ""source_locator"": ""/ptools-xml/Protein/catalyzes; /ptools-xml/Protein/comment; /ptools-xml/Protein/dblink""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""The reconstituted E/F/G preparation forms A. Discussion assigns lysine activation/loading and two condensations to MxcG, and terminal two-stage reduction to its reductase domain. NADH also supports formation more slowly than NADPH."", ""source_locator"": ""//*[@id=\""sec9\""]/p[1]; //*[@id=\""sec11\""]/p[3]; //*[@id=\""sec11\""]/p[5]""}, {""reference_id"": ""DOI:10.1021/ja8025278"", ""source_assertion"": ""The complete enzyme preparation produces A and B; low amounts of free aldehyde were detected and characterized by LC-MS/MS and PFBHA derivatization."", ""source_locator"": ""S2-S3 Reconstitution in vitro; S3 Detection of the aldehyde intermediate; S4 Figure S-3""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""E/F/G genes were amplified from Sg a15 DNA using AF299336 primers. Intein-chitin constructs carry C-terminal extensions; purification and processing distinguish assayed proteins from exact bare native sequences."", ""source_locator"": ""//*[@id=\""sec2\""]/p[1]; //*[@id=\""sec3\""]/p[1]""}]"	"[{""id"": ""DOI:10.1021/ja8025278"", ""source_sha256"": ""3e242f7d232af6b285fc1bc7b4d97cda4b85a03714332a50437e55917c9238fd"", ""source_version"": ""2008 original official four-page supporting information, DOI-linked ACS Figshare; main body not acquired locally"", ""title"": ""Myxochelin biosynthesis: direct evidence for two- and four-electron reduction of a carrier protein-bound thioester. — Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/4631935""}, {""id"": ""MetaCyc:MONOMER-124162"", ""source_sha256"": ""342f5a8a0da825da6aba706feecff75be81bb2d3518cd834b5811ebb412d8c79"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native MONOMER-124162"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:MONOMER-124162""}, {""id"": ""NCBIProtein:AAG31130.1"", ""source_sha256"": ""e9ef9bc9825dda8aa6e027cc381faf09a287571ebdff2f582a143a7797226ed6"", ""source_version"": ""Original versioned AF299336.1 GenBank XML; reference digest covers whole nucleotide record, exact CDS qualifier selected"", ""title"": ""AAG31130.1 mxcG native translation in Sg a15 AF299336.1"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=nuccore&id=AF299336.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}, {""id"": ""UniProtKB:Q9F636"", ""source_sha256"": ""b2c2489d9c5bf61e4b46b4f8a81a48af8f8dd3024afe7f08970b914de549d215"", ""source_version"": ""Original individual UniProt JSON; unreviewed species-level entry; exact native sequence separately bridged to AF299336.1"", ""title"": ""UniProtKB Q9F636 mxcG"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9F636.json""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-064_c053dd8fe768	UniProtKB:Q9F631	pathwaymech:enables	MetaCyc:RXN-23315	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/ja8025278|MetaCyc:MONOMER-124163|NCBIProtein:AAG31135.1|UniProtKB:Q9F631	Native gene-product/activity relation supported by source annotation and qualified recombinant reconstitution. No fixed E:F:G:L assembly is asserted. The 2008 tagged preparation is linked through the cited earlier plasmid; its complete engineered sequence was not independently reconstructed.	"[{""reference_id"": ""NCBIProtein:AAG31135.1"", ""source_assertion"": ""The mxcL CDS in AF299336.1 supplies AAG31135.1, 420 residues, from Sg a15. Its native translation is exactly identical to the selected UniProt sequence; engineered tags and processing are separate."", ""source_locator"": ""//GBFeature[GBFeature_key=\""CDS\""][GBFeature_quals/GBQualifier[GBQualifier_name=\""gene\""]/GBQualifier_value=\""mxcL\""]/GBFeature_quals; //GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}, {""reference_id"": ""UniProtKB:Q9F631"", ""source_assertion"": ""The entry provides the selected full native sequence and versioned EMBL protein cross-reference. This unreviewed species-level annotation is not itself an experimental assay."", ""source_locator"": ""/primaryAccession; /sequence; /uniProtKBCrossReferences; /entryType; /organism""}, {""reference_id"": ""MetaCyc:MONOMER-124163"", ""source_assertion"": ""The source links Q9F631/AAG31135.1 in Sg a15 to the MxcL aminotransferase and ENZRXN-31013/RXN-23315. It describes the later recombinant E/F/G/L reconstitution; the 2001 paper only proposed this function."", ""source_locator"": ""/ptools-xml/Protein/catalyzes/Enzymatic-Reaction/reaction; /ptools-xml/Protein/comment; /ptools-xml/Protein/dblink""}, {""reference_id"": ""DOI:10.1021/ja8025278"", ""source_assertion"": ""His6-MxcL was amplified from pCBP-MxcL and expressed in E. coli. E/F/G/L with glutamate produces A and B; free aldehyde is detected. The earlier pCBP construct is cited, not fully sequenced in this supplement."", ""source_locator"": ""S1 Cloning of mxcL; S1-S2 Overexpression and purification; S2-S3 Reconstitution in vitro; S3-S4 aldehyde analysis""}]"	"[{""id"": ""DOI:10.1021/ja8025278"", ""source_sha256"": ""3e242f7d232af6b285fc1bc7b4d97cda4b85a03714332a50437e55917c9238fd"", ""source_version"": ""2008 original official four-page supporting information, DOI-linked ACS Figshare; main body not acquired locally"", ""title"": ""Myxochelin biosynthesis: direct evidence for two- and four-electron reduction of a carrier protein-bound thioester. — Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/4631935""}, {""id"": ""MetaCyc:MONOMER-124163"", ""source_sha256"": ""854c991b72cf3c44e322285184d41d01a67fea9c3cc76a67d384fd47b0bccc04"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native MONOMER-124163"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:MONOMER-124163""}, {""id"": ""NCBIProtein:AAG31135.1"", ""source_sha256"": ""e9ef9bc9825dda8aa6e027cc381faf09a287571ebdff2f582a143a7797226ed6"", ""source_version"": ""Original versioned AF299336.1 GenBank XML; reference digest covers whole nucleotide record, exact CDS qualifier selected"", ""title"": ""AAG31135.1 mxcL native translation in Sg a15 AF299336.1"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=nuccore&id=AF299336.1&rettype=gb&retmode=xml""}, {""id"": ""UniProtKB:Q9F631"", ""source_sha256"": ""765ce863b32783358d80c3fb01311aead45aea73de63b57a23fc8692598f290d"", ""source_version"": ""Original individual UniProt JSON; unreviewed species-level entry; exact native sequence separately bridged to AF299336.1"", ""title"": ""UniProtKB Q9F631 mxcL"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9F631.json""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-065_d39ac5583b4a	UniProtKB:Q9F637	pathwaymech:enables	MetaCyc:RXN-23316	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAG31129.1|PMID:11562468|UniProtKB:Q9F637	Carrier contribution, not independent condensation catalysis or a fixed physical stoichiometry. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""NCBIProtein:AAG31129.1"", ""source_assertion"": ""The mxcF CDS in AF299336.1 supplies AAG31129.1, 311 residues, from Sg a15. Its native translation is exactly identical to the selected UniProt sequence; engineered tags and processing are separate."", ""source_locator"": ""//GBFeature[GBFeature_key=\""CDS\""][GBFeature_quals/GBQualifier[GBQualifier_name=\""gene\""]/GBQualifier_value=\""mxcF\""]/GBFeature_quals; //GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}, {""reference_id"": ""UniProtKB:Q9F637"", ""source_assertion"": ""The entry provides the selected full native sequence and versioned EMBL protein cross-reference. This unreviewed species-level annotation is not itself an experimental assay."", ""source_locator"": ""/primaryAccession; /sequence; /uniProtKBCrossReferences; /entryType; /organism""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""The MxcF aryl-carrier delivers activated DHB twice. The paper leaves reuse of one physical carrier versus two separately loaded carriers unresolved."", ""source_locator"": ""//*[@id=\""sec11\""]/p[5]""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""NCBIProtein:AAG31129.1"", ""source_sha256"": ""e9ef9bc9825dda8aa6e027cc381faf09a287571ebdff2f582a143a7797226ed6"", ""source_version"": ""Original versioned AF299336.1 GenBank XML; reference digest covers whole nucleotide record, exact CDS qualifier selected"", ""title"": ""AAG31129.1 mxcF native translation in Sg a15 AF299336.1"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=nuccore&id=AF299336.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}, {""id"": ""UniProtKB:Q9F637"", ""source_sha256"": ""d69d7a23ea2fcfea4209243c91cc80ee0292081f196b3f51d78c75fef9be4ab3"", ""source_version"": ""Original individual UniProt JSON; unreviewed species-level entry; exact native sequence separately bridged to AF299336.1"", ""title"": ""UniProtKB Q9F637 mxcF"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9F637.json""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-066_064a28ebafea	UniProtKB:Q9F637	pathwaymech:enables	MetaCyc:RXN-23312	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAG31129.1|PMID:11562468|UniProtKB:Q9F637	Carrier contribution, not independent condensation catalysis or a fixed physical stoichiometry. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""NCBIProtein:AAG31129.1"", ""source_assertion"": ""The mxcF CDS in AF299336.1 supplies AAG31129.1, 311 residues, from Sg a15. Its native translation is exactly identical to the selected UniProt sequence; engineered tags and processing are separate."", ""source_locator"": ""//GBFeature[GBFeature_key=\""CDS\""][GBFeature_quals/GBQualifier[GBQualifier_name=\""gene\""]/GBQualifier_value=\""mxcF\""]/GBFeature_quals; //GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}, {""reference_id"": ""UniProtKB:Q9F637"", ""source_assertion"": ""The entry provides the selected full native sequence and versioned EMBL protein cross-reference. This unreviewed species-level annotation is not itself an experimental assay."", ""source_locator"": ""/primaryAccession; /sequence; /uniProtKBCrossReferences; /entryType; /organism""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""The MxcF aryl-carrier delivers activated DHB twice. The paper leaves reuse of one physical carrier versus two separately loaded carriers unresolved."", ""source_locator"": ""//*[@id=\""sec11\""]/p[5]""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""NCBIProtein:AAG31129.1"", ""source_sha256"": ""e9ef9bc9825dda8aa6e027cc381faf09a287571ebdff2f582a143a7797226ed6"", ""source_version"": ""Original versioned AF299336.1 GenBank XML; reference digest covers whole nucleotide record, exact CDS qualifier selected"", ""title"": ""AAG31129.1 mxcF native translation in Sg a15 AF299336.1"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=nuccore&id=AF299336.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}, {""id"": ""UniProtKB:Q9F637"", ""source_sha256"": ""d69d7a23ea2fcfea4209243c91cc80ee0292081f196b3f51d78c75fef9be4ab3"", ""source_version"": ""Original individual UniProt JSON; unreviewed species-level entry; exact native sequence separately bridged to AF299336.1"", ""title"": ""UniProtKB Q9F637 mxcF"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9F637.json""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-067_0a4f18ede0c5	UniProtKB:Q9F637	pathwaymech:has_cofactor	CHEBI:47942	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAG31129.1|PMID:11562468|UniProtKB:Q9F637	Covalent carrier prosthetic-group role. Heterologous MtaA maturation is supporting context outside the nine-member route; its identity is not transferred to a native activation edge.	"[{""reference_id"": ""UniProtKB:Q9F637"", ""source_assertion"": ""The current unreviewed entry annotates covalent phosphopantetheine association with ECO:0000256 rule-based evidence, not an independent native-strain binding assay."", ""source_locator"": ""/comments/1/cofactors""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""MtaA coexpression increases MxcF and separately expressed PCPG mass by about 340 Da. This directly supports phosphopantetheinylation of these constructs, not measured full-length MxcG occupancy or an identified native Sg a15 PPTase."", ""source_locator"": ""//*[@id=\""sec8\""]/p[1]; //*[@id=\""sec5\""]/p[1]""}, {""reference_id"": ""NCBIProtein:AAG31129.1"", ""source_assertion"": ""The mxcF CDS in AF299336.1 supplies AAG31129.1, 311 residues, from Sg a15. Its native translation is exactly identical to the selected UniProt sequence; engineered tags and processing are separate."", ""source_locator"": ""//GBFeature[GBFeature_key=\""CDS\""][GBFeature_quals/GBQualifier[GBQualifier_name=\""gene\""]/GBQualifier_value=\""mxcF\""]/GBFeature_quals; //GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}, {""reference_id"": ""UniProtKB:Q9F637"", ""source_assertion"": ""The entry provides the selected full native sequence and versioned EMBL protein cross-reference. This unreviewed species-level annotation is not itself an experimental assay."", ""source_locator"": ""/primaryAccession; /sequence; /uniProtKBCrossReferences; /entryType; /organism""}]"	"[{""id"": ""NCBIProtein:AAG31129.1"", ""source_sha256"": ""e9ef9bc9825dda8aa6e027cc381faf09a287571ebdff2f582a143a7797226ed6"", ""source_version"": ""Original versioned AF299336.1 GenBank XML; reference digest covers whole nucleotide record, exact CDS qualifier selected"", ""title"": ""AAG31129.1 mxcF native translation in Sg a15 AF299336.1"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=nuccore&id=AF299336.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}, {""id"": ""UniProtKB:Q9F637"", ""source_sha256"": ""d69d7a23ea2fcfea4209243c91cc80ee0292081f196b3f51d78c75fef9be4ab3"", ""source_version"": ""Original individual UniProt JSON; unreviewed species-level entry; exact native sequence separately bridged to AF299336.1"", ""title"": ""UniProtKB Q9F637 mxcF"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9F637.json""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-068_6170328f4d44	UniProtKB:Q9F636	pathwaymech:has_cofactor	CHEBI:47942	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAG31130.1|PMID:11562468|UniProtKB:Q9F636	Covalent carrier prosthetic-group role. Heterologous MtaA maturation is supporting context outside the nine-member route; its identity is not transferred to a native activation edge.	"[{""reference_id"": ""UniProtKB:Q9F636"", ""source_assertion"": ""The current unreviewed entry annotates covalent phosphopantetheine association with ECO:0000256 rule-based evidence, not an independent native-strain binding assay."", ""source_locator"": ""/comments/0/cofactors""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""MtaA coexpression increases MxcF and separately expressed PCPG mass by about 340 Da. This directly supports phosphopantetheinylation of these constructs, not measured full-length MxcG occupancy or an identified native Sg a15 PPTase."", ""source_locator"": ""//*[@id=\""sec8\""]/p[1]; //*[@id=\""sec5\""]/p[1]""}, {""reference_id"": ""NCBIProtein:AAG31130.1"", ""source_assertion"": ""The mxcG CDS in AF299336.1 supplies AAG31130.1, 1456 residues, from Sg a15. Its native translation is exactly identical to the selected UniProt sequence; engineered tags and processing are separate."", ""source_locator"": ""//GBFeature[GBFeature_key=\""CDS\""][GBFeature_quals/GBQualifier[GBQualifier_name=\""gene\""]/GBQualifier_value=\""mxcG\""]/GBFeature_quals; //GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}, {""reference_id"": ""UniProtKB:Q9F636"", ""source_assertion"": ""The entry provides the selected full native sequence and versioned EMBL protein cross-reference. This unreviewed species-level annotation is not itself an experimental assay."", ""source_locator"": ""/primaryAccession; /sequence; /uniProtKBCrossReferences; /entryType; /organism""}]"	"[{""id"": ""NCBIProtein:AAG31130.1"", ""source_sha256"": ""e9ef9bc9825dda8aa6e027cc381faf09a287571ebdff2f582a143a7797226ed6"", ""source_version"": ""Original versioned AF299336.1 GenBank XML; reference digest covers whole nucleotide record, exact CDS qualifier selected"", ""title"": ""AAG31130.1 mxcG native translation in Sg a15 AF299336.1"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=nuccore&id=AF299336.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}, {""id"": ""UniProtKB:Q9F636"", ""source_sha256"": ""b2c2489d9c5bf61e4b46b4f8a81a48af8f8dd3024afe7f08970b914de549d215"", ""source_version"": ""Original individual UniProt JSON; unreviewed species-level entry; exact native sequence separately bridged to AF299336.1"", ""title"": ""UniProtKB Q9F636 mxcG"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9F636.json""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-069_0fe4306ab628	UniProtKB:Q9F631	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/ja8025278|NCBIProtein:AAG31135.1|UniProtKB:Q9F631	PLP-dependent aminotransferase model with direct tagged-preparation spectroscopy and separately inferred native annotation; no cofactor stoichiometry claimed.	"[{""reference_id"": ""UniProtKB:Q9F631"", ""source_assertion"": ""The unreviewed entry annotates pyridoxal 5-prime-phosphate with ECO:0000256 ARBA evidence. This is distinct from the experimental tagged-preparation spectroscopy."", ""source_locator"": ""/comments/0/cofactors""}, {""reference_id"": ""DOI:10.1021/ja8025278"", ""source_assertion"": ""His6-MxcL incubated with PLP was buffer-exchanged before spectroscopy; addition of glutamate changes the PLP/PMP-associated UV spectrum."", ""source_locator"": ""S2 Spectrophotometric measurement of PLP-bound MxcL and Figure S-1""}, {""reference_id"": ""NCBIProtein:AAG31135.1"", ""source_assertion"": ""The mxcL CDS in AF299336.1 supplies AAG31135.1, 420 residues, from Sg a15. Its native translation is exactly identical to the selected UniProt sequence; engineered tags and processing are separate."", ""source_locator"": ""//GBFeature[GBFeature_key=\""CDS\""][GBFeature_quals/GBQualifier[GBQualifier_name=\""gene\""]/GBQualifier_value=\""mxcL\""]/GBFeature_quals; //GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}, {""reference_id"": ""UniProtKB:Q9F631"", ""source_assertion"": ""The entry provides the selected full native sequence and versioned EMBL protein cross-reference. This unreviewed species-level annotation is not itself an experimental assay."", ""source_locator"": ""/primaryAccession; /sequence; /uniProtKBCrossReferences; /entryType; /organism""}]"	"[{""id"": ""DOI:10.1021/ja8025278"", ""source_sha256"": ""3e242f7d232af6b285fc1bc7b4d97cda4b85a03714332a50437e55917c9238fd"", ""source_version"": ""2008 original official four-page supporting information, DOI-linked ACS Figshare; main body not acquired locally"", ""title"": ""Myxochelin biosynthesis: direct evidence for two- and four-electron reduction of a carrier protein-bound thioester. — Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/4631935""}, {""id"": ""NCBIProtein:AAG31135.1"", ""source_sha256"": ""e9ef9bc9825dda8aa6e027cc381faf09a287571ebdff2f582a143a7797226ed6"", ""source_version"": ""Original versioned AF299336.1 GenBank XML; reference digest covers whole nucleotide record, exact CDS qualifier selected"", ""title"": ""AAG31135.1 mxcL native translation in Sg a15 AF299336.1"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=nuccore&id=AF299336.1&rettype=gb&retmode=xml""}, {""id"": ""UniProtKB:Q9F631"", ""source_sha256"": ""765ce863b32783358d80c3fb01311aead45aea73de63b57a23fc8692598f290d"", ""source_version"": ""Original individual UniProt JSON; unreviewed species-level entry; exact native sequence separately bridged to AF299336.1"", ""title"": ""UniProtKB Q9F631 mxcL"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9F631.json""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-070_93cf40aab6f7	MetaCyc:DHBAMPLIG-RXN	RO:0002413	MetaCyc:RXN-23310	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DHBAMPLIG-RXN|MetaCyc:RXN-23310	Shared material: CHEBI:57417. This does not establish physical channeling or simultaneous carrier occupancy.	"[{""reference_id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_assertion"": ""The original right side contains CPD-62 with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""DHBAMPLIG-RXN\""]/right[*[@frameid=\""CPD-62\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:RXN-23310"", ""source_assertion"": ""The original left side contains CPD-62 with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23310\""]/left[*[@frameid=\""CPD-62\""]]; /ptools-xml/Reaction/reaction-direction""}]"	"[{""id"": ""MetaCyc:DHBAMPLIG-RXN"", ""source_sha256"": ""87918421a3ef2314109444083e25ed14907e147bf9b87ff34c5c14b614db8a04"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native DHBAMPLIG-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:DHBAMPLIG-RXN""}, {""id"": ""MetaCyc:RXN-23310"", ""source_sha256"": ""93240fea2e11613e9a624aadb68aa9c0691ef41e05d155c84e9dfc5629a367c9"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23310"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23310""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-071_0b8bf125b010	MetaCyc:RXN-22679	RO:0002413	MetaCyc:RXN-23308	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-22679|MetaCyc:RXN-23308	Shared material: CHEBI:176581. This does not establish physical channeling or simultaneous carrier occupancy.	"[{""reference_id"": ""MetaCyc:RXN-22679"", ""source_assertion"": ""The original right side contains CPD-24910 with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-22679\""]/right[*[@frameid=\""CPD-24910\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:RXN-23308"", ""source_assertion"": ""The original left side contains CPD-24910 with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23308\""]/left[*[@frameid=\""CPD-24910\""]]; /ptools-xml/Reaction/reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-22679"", ""source_sha256"": ""02dff777c34ed90d031dc418c88070660ec60ba79055f76b1f3e1718524ee36e"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-22679"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-22679""}, {""id"": ""MetaCyc:RXN-23308"", ""source_sha256"": ""f6df3f410be328f11f9e88ca965ae746be735054fea2438ba267b7effd9986ea"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23308"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23308""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-072_ddc76900b762	MetaCyc:RXN-23310	RO:0002413	MetaCyc:RXN-23316	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-23310|MetaCyc:RXN-23316|PMID:11562468	Shared material: MetaCyc:23-DHB-MxcF. This does not establish physical channeling or simultaneous carrier occupancy. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""MetaCyc:RXN-23310"", ""source_assertion"": ""The original right side contains 23-DHB-MxcF with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23310\""]/right[*[@frameid=\""23-DHB-MxcF\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:RXN-23316"", ""source_assertion"": ""The original left side contains 23-DHB-MxcF with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23316\""]/left[*[@frameid=\""23-DHB-MxcF\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""MetaCyc:RXN-23310"", ""source_sha256"": ""93240fea2e11613e9a624aadb68aa9c0691ef41e05d155c84e9dfc5629a367c9"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23310"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23310""}, {""id"": ""MetaCyc:RXN-23316"", ""source_sha256"": ""1d524ccbb2d2d749e3398e2b829ca4484340786e29d038f36d46f7837fd4fe23"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23316"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23316""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-073_b998da7f3052	MetaCyc:RXN-23310	RO:0002413	MetaCyc:RXN-23312	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-23310|MetaCyc:RXN-23312|PMID:11562468	Shared material: MetaCyc:23-DHB-MxcF. This does not establish physical channeling or simultaneous carrier occupancy. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""MetaCyc:RXN-23310"", ""source_assertion"": ""The original right side contains 23-DHB-MxcF with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23310\""]/right[*[@frameid=\""23-DHB-MxcF\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:RXN-23312"", ""source_assertion"": ""The original left side contains 23-DHB-MxcF with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23312\""]/left[*[@frameid=\""23-DHB-MxcF\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""MetaCyc:RXN-23310"", ""source_sha256"": ""93240fea2e11613e9a624aadb68aa9c0691ef41e05d155c84e9dfc5629a367c9"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23310"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23310""}, {""id"": ""MetaCyc:RXN-23312"", ""source_sha256"": ""9e135b1f855f618eb0a32e00edc968a94fc01505061b090d1d5f0591e7649c01"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23312"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23312""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-074_73309c025689	MetaCyc:RXN-23308	RO:0002413	MetaCyc:RXN-23316	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-23308|MetaCyc:RXN-23316|PMID:11562468	Shared material: MetaCyc:Lysyl-MxcG. This does not establish physical channeling or simultaneous carrier occupancy. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""MetaCyc:RXN-23308"", ""source_assertion"": ""The original right side contains Lysyl-MxcG with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23308\""]/right[*[@frameid=\""Lysyl-MxcG\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:RXN-23316"", ""source_assertion"": ""The original left side contains Lysyl-MxcG with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23316\""]/left[*[@frameid=\""Lysyl-MxcG\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""MetaCyc:RXN-23308"", ""source_sha256"": ""f6df3f410be328f11f9e88ca965ae746be735054fea2438ba267b7effd9986ea"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23308"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23308""}, {""id"": ""MetaCyc:RXN-23316"", ""source_sha256"": ""1d524ccbb2d2d749e3398e2b829ca4484340786e29d038f36d46f7837fd4fe23"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23316"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23316""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-075_ad6f14993ae2	MetaCyc:RXN-23316	RO:0002413	MetaCyc:RXN-23312	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-23312|MetaCyc:RXN-23316|PMID:11562468	Shared material: MetaCyc:N-23-DHB-Lysyl-MxcG. This does not establish physical channeling or simultaneous carrier occupancy. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""MetaCyc:RXN-23316"", ""source_assertion"": ""The original right side contains N-23-DHB-Lysyl-MxcG with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23316\""]/right[*[@frameid=\""N-23-DHB-Lysyl-MxcG\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:RXN-23312"", ""source_assertion"": ""The original left side contains N-23-DHB-Lysyl-MxcG with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23312\""]/left[*[@frameid=\""N-23-DHB-Lysyl-MxcG\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""MetaCyc:RXN-23312"", ""source_sha256"": ""9e135b1f855f618eb0a32e00edc968a94fc01505061b090d1d5f0591e7649c01"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23312"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23312""}, {""id"": ""MetaCyc:RXN-23316"", ""source_sha256"": ""1d524ccbb2d2d749e3398e2b829ca4484340786e29d038f36d46f7837fd4fe23"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23316"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23316""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-076_2635caf1ac7e	MetaCyc:RXN-23312	RO:0002413	MetaCyc:RXN-23313	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-23312|MetaCyc:RXN-23313|PMID:11562468	Shared material: MetaCyc:N-N-di23-DHB-Lysyl-MxcG. This does not establish physical channeling or simultaneous carrier occupancy. N6-first is the selected native database convention; the first amidated lysine nitrogen is experimentally unresolved, not demonstrated to be N6 or exclusive.	"[{""reference_id"": ""MetaCyc:RXN-23312"", ""source_assertion"": ""The original right side contains N-N-di23-DHB-Lysyl-MxcG with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23312\""]/right[*[@frameid=\""N-N-di23-DHB-Lysyl-MxcG\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:RXN-23313"", ""source_assertion"": ""The original left side contains N-N-di23-DHB-Lysyl-MxcG with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23313\""]/left[*[@frameid=\""N-N-di23-DHB-Lysyl-MxcG\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""PMID:11562468"", ""source_assertion"": ""Figure 5C states that it is not known which lysine amide forms first. It supports both condensations but does not experimentally establish the selected native N6-first intermediate."", ""source_locator"": ""//*[@id=\""F5\""]/figcaption/p""}]"	"[{""id"": ""MetaCyc:RXN-23312"", ""source_sha256"": ""9e135b1f855f618eb0a32e00edc968a94fc01505061b090d1d5f0591e7649c01"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23312"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23312""}, {""id"": ""MetaCyc:RXN-23313"", ""source_sha256"": ""58ee147cf9663d49a8983e20634258902792c8538013c634d932ea87b2ede4c3"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23313"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23313""}, {""id"": ""PMID:11562468"", ""source_sha256"": ""bb6c753d74cc5d2461d994162ae1c9b65710dc912cda322b50f801b64c8821e2"", ""source_version"": ""2001 original full PNAS article in PMC HTML; retrieved 2026-10-11"", ""title"": ""In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC58696/""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-077_0b0e71cca54e	MetaCyc:RXN-23313	RO:0002413	MetaCyc:RXN-23314	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/ja8025278|MetaCyc:RXN-23313|MetaCyc:RXN-23314	Shared material: MetaCyc:CPD-25916. This does not establish physical channeling or simultaneous carrier occupancy.	"[{""reference_id"": ""MetaCyc:RXN-23313"", ""source_assertion"": ""The original right side contains CPD-25916 with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23313\""]/right[*[@frameid=\""CPD-25916\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:RXN-23314"", ""source_assertion"": ""The original right side contains CPD-25916 with coefficient 1; native direction is PHYSIOL-RIGHT-TO-LEFT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23314\""]/right[*[@frameid=\""CPD-25916\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""DOI:10.1021/ja8025278"", ""source_assertion"": ""Low amounts of a free aldehyde intermediate were detected by LC-MS/MS and PFBHA derivatization in the complete reconstitution. Both product branches are retained."", ""source_locator"": ""S3 Detection of the aldehyde intermediate; S4 Figure S-3""}]"	"[{""id"": ""DOI:10.1021/ja8025278"", ""source_sha256"": ""3e242f7d232af6b285fc1bc7b4d97cda4b85a03714332a50437e55917c9238fd"", ""source_version"": ""2008 original official four-page supporting information, DOI-linked ACS Figshare; main body not acquired locally"", ""title"": ""Myxochelin biosynthesis: direct evidence for two- and four-electron reduction of a carrier protein-bound thioester. — Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/4631935""}, {""id"": ""MetaCyc:RXN-23313"", ""source_sha256"": ""58ee147cf9663d49a8983e20634258902792c8538013c634d932ea87b2ede4c3"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23313"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23313""}, {""id"": ""MetaCyc:RXN-23314"", ""source_sha256"": ""64acdd14d9e27fda70747a5cd18ff67b83b034022dbb544de0ee560f7e5454e9"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23314"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23314""}]"	""
pathwaymech:MetaCyc_PWY-8383_myxochelin-edge-078_f9f63326960a	MetaCyc:RXN-23313	RO:0002413	MetaCyc:RXN-23315	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/ja8025278|MetaCyc:RXN-23313|MetaCyc:RXN-23315	Shared material: MetaCyc:CPD-25916. This does not establish physical channeling or simultaneous carrier occupancy.	"[{""reference_id"": ""MetaCyc:RXN-23313"", ""source_assertion"": ""The original right side contains CPD-25916 with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected output in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23313\""]/right[*[@frameid=\""CPD-25916\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""MetaCyc:RXN-23315"", ""source_assertion"": ""The original left side contains CPD-25916 with coefficient 1; native direction is PHYSIOL-LEFT-TO-RIGHT. This is the selected input in pathway flux."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-23315\""]/left[*[@frameid=\""CPD-25916\""]]; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""DOI:10.1021/ja8025278"", ""source_assertion"": ""Low amounts of a free aldehyde intermediate were detected by LC-MS/MS and PFBHA derivatization in the complete reconstitution. Both product branches are retained."", ""source_locator"": ""S3 Detection of the aldehyde intermediate; S4 Figure S-3""}]"	"[{""id"": ""DOI:10.1021/ja8025278"", ""source_sha256"": ""3e242f7d232af6b285fc1bc7b4d97cda4b85a03714332a50437e55917c9238fd"", ""source_version"": ""2008 original official four-page supporting information, DOI-linked ACS Figshare; main body not acquired locally"", ""title"": ""Myxochelin biosynthesis: direct evidence for two- and four-electron reduction of a carrier protein-bound thioester. — Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/4631935""}, {""id"": ""MetaCyc:RXN-23313"", ""source_sha256"": ""58ee147cf9663d49a8983e20634258902792c8538013c634d932ea87b2ede4c3"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23313"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23313""}, {""id"": ""MetaCyc:RXN-23315"", ""source_sha256"": ""1a6b7e23e6fc72435bc79bfa4f9b004a880545d4cba1f85c1da9bfe9333fe7a7"", ""source_version"": ""MetaCyc 27.0 original XML; retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-23315"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-23315""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-001_ee6c1567dadf	CHEBI:15377	pathwaymech:consumes	RHEA:22937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22937		"[{""reference_id"": ""RHEA:22937"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:22937 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22937']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22937"", ""source_version"": ""139"", ""title"": ""Rhea D-glucosamine-6-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22937""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-002_e93cbe7c9a89	CHEBI:57513	pathwaymech:consumes	RHEA:22937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22937		"[{""reference_id"": ""RHEA:22937"", ""source_assertion"": ""Rhea lists CHEBI:57513 on the substrates side of RHEA:22937 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22937']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22937"", ""source_version"": ""139"", ""title"": ""Rhea D-glucosamine-6-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22937""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-003_19ba2b4e3608	RHEA:22937	pathwaymech:produces	CHEBI:30089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22937		"[{""reference_id"": ""RHEA:22937"", ""source_assertion"": ""Rhea lists CHEBI:30089 on the products side of RHEA:22937 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22937']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22937"", ""source_version"": ""139"", ""title"": ""Rhea D-glucosamine-6-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22937""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-004_1ecd169b3b12	RHEA:22937	pathwaymech:produces	CHEBI:58725	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22937		"[{""reference_id"": ""RHEA:22937"", ""source_assertion"": ""Rhea lists CHEBI:58725 on the products side of RHEA:22937 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22937']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22937"", ""source_version"": ""139"", ""title"": ""Rhea D-glucosamine-6-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22937""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-005_6f4235a87cfc	CHEBI:15377	pathwaymech:consumes	RHEA:12173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12173		"[{""reference_id"": ""RHEA:12173"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:12173 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12173']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12173"", ""source_version"": ""139"", ""title"": ""RHEA:12173 authority record"", ""url"": ""https://www.rhea-db.org/rhea/12173""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-006_8d6ca0a18dfc	CHEBI:75989	pathwaymech:consumes	RHEA:12173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12173		"[{""reference_id"": ""RHEA:12173"", ""source_assertion"": ""Rhea lists CHEBI:75989 on the substrates side of RHEA:12173 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12173']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12173"", ""source_version"": ""139"", ""title"": ""RHEA:12173 authority record"", ""url"": ""https://www.rhea-db.org/rhea/12173""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-007_ac0757cf455a	RHEA:12173	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12173		"[{""reference_id"": ""RHEA:12173"", ""source_assertion"": ""Rhea lists CHEBI:28938 on the products side of RHEA:12173 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12173']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12173"", ""source_version"": ""139"", ""title"": ""RHEA:12173 authority record"", ""url"": ""https://www.rhea-db.org/rhea/12173""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-008_e3cab6b72372	RHEA:12173	pathwaymech:produces	CHEBI:57634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12173		"[{""reference_id"": ""RHEA:12173"", ""source_assertion"": ""Rhea lists CHEBI:57634 on the products side of RHEA:12173 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12173']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12173"", ""source_version"": ""139"", ""title"": ""RHEA:12173 authority record"", ""url"": ""https://www.rhea-db.org/rhea/12173""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-009_178eba36779d	EC:3.5.1.25	pathwaymech:catalyzes	RHEA:22937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22936		"[{""reference_id"": ""RHEA:22936"", ""source_assertion"": ""Rhea associates EC:3.5.1.25 with the reaction family containing RHEA:22937."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:22936"", ""source_version"": ""139"", ""title"": ""Rhea N-acetylglucosamine-6-phosphate deacetylase reaction"", ""url"": ""https://www.rhea-db.org/rhea/22936""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-010_01ca6dd75ee9	EC:3.5.99.6	pathwaymech:catalyzes	RHEA:12173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12172		"[{""reference_id"": ""RHEA:12172"", ""source_assertion"": ""Rhea associates EC:3.5.99.6 with the reaction family containing RHEA:12173."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:12172"", ""source_version"": ""139"", ""title"": ""Rhea glucosamine-6-phosphate deaminase reaction"", ""url"": ""https://www.rhea-db.org/rhea/12172""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-011_b5f04ae0c7f0	RHEA:22937	pathwaymech:precedes	RHEA:12173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GLUAMCAT-PWY		"[{""reference_id"": ""MetaCyc:GLUAMCAT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:22937 before RHEA:12173 in this pathway. The source ordering may bridge anomer-specific and broader substrate classes."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:GLUAMCAT-PWY"", ""source_sha256"": ""11452cd9c22c0e02e920a9ca35a34de859024477093384c036cfe92366a58856"", ""source_version"": ""22.5"", ""title"": ""MetaCyc N-acetylglucosamine degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:GLUAMCAT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-012_7290d0cdc947	UniProtKB:P0A759	pathwaymech:enables	RHEA:12173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A759		"[{""reference_id"": ""UniProtKB:P0A759"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A759 with catalytic activity for the reaction family of RHEA:12173. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A759"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A759 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A759.json""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-013_becfbc3f9dc8	CHEBI:57513	pathwaymech:activates	UniProtKB:P0A759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A759		"[{""reference_id"": ""UniProtKB:P0A759"", ""source_assertion"": ""UniProt activity-regulation annotation: Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P). Competitively inhibited by 2-amino-2-deoxy-D-glucitol-6-phosphate (GlcN-ol-6P)"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P0A759"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A759 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A759.json""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-014_637d99d26c28	UniProtKB:P0AF18	pathwaymech:enables	RHEA:22937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF18		"[{""reference_id"": ""UniProtKB:P0AF18"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AF18 with catalytic activity for the reaction family of RHEA:22937. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AF18"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AF18 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF18.json""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-015_b91148474c27	CHEBI:58725	pathwaymech:inhibits	UniProtKB:P0AF18	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF18		"[{""reference_id"": ""UniProtKB:P0AF18"", ""source_assertion"": ""UniProt activity-regulation annotation: Inhibited by high substrate concentration and by products glucosamine 6-phosphate and acetate. Completely inactivated by the treatment with 5,5'-dithio-bis(2-nitrobenzoate) or 2,2'-dithio-pyridine (2-DPDS). Inhibited by 1,10-phenanthroline and EDTA"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P0AF18"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AF18 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF18.json""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-016_26b16c811606	CHEBI:30089	pathwaymech:inhibits	UniProtKB:P0AF18	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF18		"[{""reference_id"": ""UniProtKB:P0AF18"", ""source_assertion"": ""UniProt activity-regulation annotation: Inhibited by high substrate concentration and by products glucosamine 6-phosphate and acetate. Completely inactivated by the treatment with 5,5'-dithio-bis(2-nitrobenzoate) or 2,2'-dithio-pyridine (2-DPDS). Inhibited by 1,10-phenanthroline and EDTA"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P0AF18"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AF18 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF18.json""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-017_a285fab92247	UniProtKB:P0AF18	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF18		"[{""reference_id"": ""UniProtKB:P0AF18"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P0AF18 (evidence: ECO:0000269). Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AF18"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AF18 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF18.json""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-018_40cd353eaab3	UniProtKB:P0AF18	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF18		"[{""reference_id"": ""UniProtKB:P0AF18"", ""source_assertion"": ""UniProt lists CHEBI:48828 as a cofactor of UniProtKB:P0AF18 (evidence: ECO:0000269). Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AF18"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AF18 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF18.json""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-019_3ad265502490	UniProtKB:P0AF18	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF18		"[{""reference_id"": ""UniProtKB:P0AF18"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P0AF18 (evidence: ECO:0000269). Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AF18"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AF18 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF18.json""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-020_fa9cecfb0b64	UniProtKB:P0AF18	pathwaymech:has_cofactor	CHEBI:48775	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF18		"[{""reference_id"": ""UniProtKB:P0AF18"", ""source_assertion"": ""UniProt lists CHEBI:48775 as a cofactor of UniProtKB:P0AF18 (evidence: ECO:0000269). Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AF18"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AF18 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF18.json""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-021_d69182b37fda	UniProtKB:P0AF18	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF18		"[{""reference_id"": ""UniProtKB:P0AF18"", ""source_assertion"": ""UniProt lists CHEBI:29033 as a cofactor of UniProtKB:P0AF18 (evidence: ECO:0000269). Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AF18"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AF18 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF18.json""}]"	""
pathwaymech:MetaCyc_GLUAMCAT-PWY_edge-022_2f161aca023a	UniProtKB:P0AF18	pathwaymech:has_cofactor	CHEBI:49786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF18		"[{""reference_id"": ""UniProtKB:P0AF18"", ""source_assertion"": ""UniProt lists CHEBI:49786 as a cofactor of UniProtKB:P0AF18 (evidence: ECO:0000269). Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AF18"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AF18 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF18.json""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-001_131786aafa20	gomodel:RXN-5721	RO:0002233	CHEBI:994	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:RXN-5721 RO:0002233 gomodel:CHEBI_994_RXN-5721."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/0; endpoint types: /individuals/24/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-002_316c9791971f	gomodel:NAD-SYNTH-GLN-RXN	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NAD-SYNTH-GLN-RXN RO:0002234 gomodel:CHEBI_57540_NAD-SYNTH-GLN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/1; endpoint types: /individuals/21/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-003_b7d3ab22cef4	gomodel:NAD-SYNTH-GLN-RXN	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NAD-SYNTH-GLN-RXN RO:0002234 gomodel:CHEBI_456215_NAD-SYNTH-GLN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/2; endpoint types: /individuals/21/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-004_520d343f64ba	gomodel:YeastPathways_PWY-5653/6a4c244800000432	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5653/6a4c244800000432 RO:0002233 gomodel:YeastPathways_PWY-5653/6a4c244800000434."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/3; endpoint types: /individuals/62/type; /individuals/64/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-005_400e659e3fdb	gomodel:YeastPathways_PWY-5653/6a4c244800000432	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5653/6a4c244800000432 RO:0002233 gomodel:YeastPathways_PWY-5653/6a4c244800000433."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/4; endpoint types: /individuals/62/type; /individuals/63/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-006_a76c460a1967	gomodel:QUINOPRIBOTRANS-RXN	BFO:0000050	GO:0009435	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:QUINOPRIBOTRANS-RXN BFO:0000050 gomodel:YeastPathways_PWY-5653/YeastPathways_PWY-5653."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/5; endpoint types: /individuals/23/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-007_58ce5746057a	gomodel:RXN-5721	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:RXN-5721 RO:0002234 gomodel:CHEBI_15377_RXN-5721."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/6; endpoint types: /individuals/24/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-008_65a982b2a2f2	gomodel:NAD-SYNTH-GLN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NAD-SYNTH-GLN-RXN RO:0002234 gomodel:CHEBI_15378_NAD-SYNTH-GLN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/7; endpoint types: /individuals/21/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-009_a884b5a4380e	gomodel:NICONUCADENYLYLTRAN-RXN	RO:0002233	CHEBI:57502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NICONUCADENYLYLTRAN-RXN RO:0002233 gomodel:CHEBI_57502_QUINOPRIBOTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/8; endpoint types: /individuals/22/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-010_8fe08ac6e7d6	gomodel:RXN-5721	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:RXN-5721 BFO:0000066 gomodel:reaction_RXN-5721_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/9; endpoint types: /individuals/24/type; /individuals/60/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-011_7c21340d0126	SGD:S000001116	pathwaymech:enables	gomodel:NAD-SYNTH-GLN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NAD-SYNTH-GLN-RXN RO:0002333 gomodel:MONOMER3O-845_NAD-SYNTH-GLN-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/10; endpoint types: /individuals/21/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-012_ac543f4c509c	gomodel:NICONUCADENYLYLTRAN-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NICONUCADENYLYLTRAN-RXN RO:0002234 gomodel:CHEBI_29888_NICONUCADENYLYLTRAN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/11; endpoint types: /individuals/22/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-013_fdac1edaea4a	gomodel:NAD-SYNTH-GLN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NAD-SYNTH-GLN-RXN RO:0002233 gomodel:CHEBI_30616_NAD-SYNTH-GLN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/12; endpoint types: /individuals/21/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-014_770d094b640a	gomodel:QUINOPRIBOTRANS-RXN	RO:0002233	CHEBI:16675	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:QUINOPRIBOTRANS-RXN RO:0002233 gomodel:CHEBI_16675_RXN-5721."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/13; endpoint types: /individuals/23/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-015_a2a3a6fe63cc	gomodel:QUINOPRIBOTRANS-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:QUINOPRIBOTRANS-RXN BFO:0000066 gomodel:reaction_QUINOPRIBOTRANS-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/14; endpoint types: /individuals/23/type; /individuals/59/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-016_c4d1e2001956	gomodel:QUINOPRIBOTRANS-RXN	RO:0002234	CHEBI:57502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:QUINOPRIBOTRANS-RXN RO:0002234 gomodel:CHEBI_57502_QUINOPRIBOTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/15; endpoint types: /individuals/23/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-017_284fe0481fb5	gomodel:NAD-SYNTH-GLN-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NAD-SYNTH-GLN-RXN RO:0002233 gomodel:CHEBI_15377_NAD-SYNTH-GLN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/16; endpoint types: /individuals/21/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-018_81bb3c943f5e	gomodel:NICONUCADENYLYLTRAN-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NICONUCADENYLYLTRAN-RXN RO:0002233 gomodel:CHEBI_15378_NICONUCADENYLYLTRAN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/17; endpoint types: /individuals/22/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-019_8ecf57ad02ab	gomodel:NAD-SYNTH-GLN-RXN	RO:0002233	CHEBI:58359	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NAD-SYNTH-GLN-RXN RO:0002233 gomodel:CHEBI_58359_NAD-SYNTH-GLN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/18; endpoint types: /individuals/21/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-020_49fc18eff07c	gomodel:YeastPathways_PWY-5653/6a4c244800000432	BFO:0000050	GO:0009435	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5653/6a4c244800000432 BFO:0000050 gomodel:YeastPathways_PWY-5653/YeastPathways_PWY-5653."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/19; endpoint types: /individuals/62/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-021_1156f3614348	gomodel:RXN-5721	BFO:0000050	GO:0009435	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:RXN-5721 BFO:0000050 gomodel:YeastPathways_PWY-5653/YeastPathways_PWY-5653."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/20; endpoint types: /individuals/24/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-022_7dbf82ee2ad8	SGD:S000001943	pathwaymech:enables	gomodel:QUINOPRIBOTRANS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:QUINOPRIBOTRANS-RXN RO:0002333 gomodel:YFR047C-MONOMER_QUINOPRIBOTRANS-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/21; endpoint types: /individuals/23/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-024_ea91435691cc	gomodel:YeastPathways_PWY-5653/6a4c244800000432	RO:0002233	CHEBI:57502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5653/6a4c244800000432 RO:0002233 gomodel:CHEBI_57502_QUINOPRIBOTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/23; endpoint types: /individuals/62/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-025_d2630ed86d0c	SGD:S000003242	pathwaymech:enables	gomodel:YeastPathways_PWY-5653/6a4c244800000432	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5653/6a4c244800000432 RO:0002333 gomodel:YeastPathways_PWY-5653/6a4c244800000436."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/24; endpoint types: /individuals/62/type; /individuals/66/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-026_4a6edd29a751	gomodel:NAD-SYNTH-GLN-RXN	RO:0002234	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NAD-SYNTH-GLN-RXN RO:0002234 gomodel:CHEBI_29985_NAD-SYNTH-GLN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/25; endpoint types: /individuals/21/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-027_be011aa8cd89	gomodel:NICONUCADENYLYLTRAN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NICONUCADENYLYLTRAN-RXN BFO:0000066 gomodel:reaction_NICONUCADENYLYLTRAN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/26; endpoint types: /individuals/22/type; /individuals/58/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-028_37fe265f3f13	gomodel:YeastPathways_PWY-5653/6a4c244800000432	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5653/6a4c244800000432 RO:0002234 gomodel:YeastPathways_PWY-5653/6a4c244800000435."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/27; endpoint types: /individuals/62/type; /individuals/65/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-029_39f68474ed67	gomodel:NAD-SYNTH-GLN-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NAD-SYNTH-GLN-RXN RO:0002234 gomodel:CHEBI_29888_NAD-SYNTH-GLN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/28; endpoint types: /individuals/21/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-030_0686fe468d11	gomodel:NICONUCADENYLYLTRAN-RXN	RO:0002234	CHEBI:58437	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NICONUCADENYLYLTRAN-RXN RO:0002234 gomodel:CHEBI_58437_NICONUCADENYLYLTRAN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/29; endpoint types: /individuals/22/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-031_c90fe6ee590b	gomodel:NICONUCADENYLYLTRAN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NICONUCADENYLYLTRAN-RXN RO:0002233 gomodel:CHEBI_30616_NICONUCADENYLYLTRAN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/30; endpoint types: /individuals/22/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-032_5e337a100de6	gomodel:QUINOPRIBOTRANS-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:QUINOPRIBOTRANS-RXN RO:0002233 gomodel:CHEBI_15378_QUINOPRIBOTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/31; endpoint types: /individuals/23/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-033_1eef11e7fdcc	gomodel:NAD-SYNTH-GLN-RXN	BFO:0000050	GO:0009435	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NAD-SYNTH-GLN-RXN BFO:0000050 gomodel:YeastPathways_PWY-5653/YeastPathways_PWY-5653."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/32; endpoint types: /individuals/21/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-034_9946cdf318a8	gomodel:NICONUCADENYLYLTRAN-RXN	BFO:0000050	GO:0009435	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NICONUCADENYLYLTRAN-RXN BFO:0000050 gomodel:YeastPathways_PWY-5653/YeastPathways_PWY-5653."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/33; endpoint types: /individuals/22/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-035_719e8e17e90c	gomodel:YeastPathways_PWY-5653/6a4c244800000432	RO:0002234	CHEBI:58437	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5653/6a4c244800000432 RO:0002234 gomodel:CHEBI_58437_NICONUCADENYLYLTRAN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/34; endpoint types: /individuals/62/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-036_79c7f8e4dcf0	gomodel:QUINOPRIBOTRANS-RXN	RO:0002233	CHEBI:58017	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:QUINOPRIBOTRANS-RXN RO:0002233 gomodel:CHEBI_58017_QUINOPRIBOTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/35; endpoint types: /individuals/23/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-037_8cc525306bd2	SGD:S000004320	pathwaymech:enables	gomodel:NICONUCADENYLYLTRAN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NICONUCADENYLYLTRAN-RXN RO:0002333 gomodel:YLR328W-MONOMER_NICONUCADENYLYLTRAN-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/36; endpoint types: /individuals/22/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-038_5e3df46c6519	gomodel:NAD-SYNTH-GLN-RXN	RO:0002233	CHEBI:58437	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NAD-SYNTH-GLN-RXN RO:0002233 gomodel:CHEBI_58437_NICONUCADENYLYLTRAN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/37; endpoint types: /individuals/21/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-039_f50ffa69eae2	gomodel:NAD-SYNTH-GLN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:NAD-SYNTH-GLN-RXN BFO:0000066 gomodel:reaction_NAD-SYNTH-GLN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/38; endpoint types: /individuals/21/type; /individuals/57/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-040_aa947ab2762c	gomodel:QUINOPRIBOTRANS-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:QUINOPRIBOTRANS-RXN RO:0002234 gomodel:CHEBI_16526_QUINOPRIBOTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/39; endpoint types: /individuals/23/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-041_326374b720ac	gomodel:RXN-5721	RO:0002234	CHEBI:16675	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:RXN-5721 RO:0002234 gomodel:CHEBI_16675_RXN-5721."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/40; endpoint types: /individuals/24/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_edge-042_939c6ba4fbf5	gomodel:QUINOPRIBOTRANS-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5653		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5653"", ""source_assertion"": ""The model asserts gomodel:QUINOPRIBOTRANS-RXN RO:0002234 gomodel:CHEBI_29888_QUINOPRIBOTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY-5653.json#/facts/41; endpoint types: /individuals/23/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5653"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-5653.json"", ""title"": ""GO-CAM NAD biosynthesis model YeastPathways_PWY-5653"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_location-854342448e1f_a20dbdb5906d	SGD:S000001943	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P43619	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P43619"", ""source_assertion"": ""UniProtKB:P43619 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3843/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P43619"", ""source_assertion"": ""UniProtKB:P43619 has the exact SGD cross-reference SGD:S000001943."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3843/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P43619"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P43619 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_location-98ab1d63f61f_10364435cde0	SGD:S000001943	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P43619	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P43619"", ""source_assertion"": ""UniProtKB:P43619 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3843/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P43619"", ""source_assertion"": ""UniProtKB:P43619 has the exact SGD cross-reference SGD:S000001943."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3843/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P43619"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P43619 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_location-e5c3511bf090_2538a0d3abac	SGD:S000003242	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53204	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11884393)	"[{""reference_id"": ""UniProtKB:P53204"", ""source_assertion"": ""UniProtKB:P53204 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2159/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53204"", ""source_assertion"": ""UniProtKB:P53204 has the exact SGD cross-reference SGD:S000003242."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2159/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53204"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53204 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_location-468dc09ff1ce_a76fa5b83b22	SGD:S000004320	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06178	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q06178"", ""source_assertion"": ""UniProtKB:Q06178 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2726/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q06178"", ""source_assertion"": ""UniProtKB:Q06178 has the exact SGD cross-reference SGD:S000004320."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2726/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q06178"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06178 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_location-cd3f40d8ca41_30879dc360b7	SGD:S000004320	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06178	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q06178"", ""source_assertion"": ""UniProtKB:Q06178 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2726/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q06178"", ""source_assertion"": ""UniProtKB:Q06178 has the exact SGD cross-reference SGD:S000004320."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2726/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q06178"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06178 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_cofactor-d2f2e51cfdb3_d7d27cddf522	SGD:S000003242	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53204	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:12597897) Divalent metal cation. UniProt note evidence: ECO:0000269 (PubMed:12597897)	"[{""reference_id"": ""UniProtKB:P53204"", ""source_assertion"": ""UniProtKB:P53204 annotates CHEBI:48828 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2159/comments/0/cofactors/0; /results/2159/comments/0/note""}, {""reference_id"": ""UniProtKB:P53204"", ""source_assertion"": ""UniProtKB:P53204 has the exact SGD cross-reference SGD:S000003242."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2159/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53204"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53204 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5653_cofactor-def4425deb9f_2271facb8e77	SGD:S000004320	pathwaymech:has_cofactor	CHEBI:49786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06178	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10428462) Divalent metal cation. UniProt note evidence: ECO:0000269 (PubMed:10428462)	"[{""reference_id"": ""UniProtKB:Q06178"", ""source_assertion"": ""UniProtKB:Q06178 annotates CHEBI:49786 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2726/comments/0/cofactors/0; /results/2726/comments/0/note""}, {""reference_id"": ""UniProtKB:Q06178"", ""source_assertion"": ""UniProtKB:Q06178 has the exact SGD cross-reference SGD:S000004320."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2726/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q06178"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06178 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-001_3e72b753f058	CHEBI:15379	pathwaymech:consumes	RHEA:25877	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25877		"[{""reference_id"": ""RHEA:25877"", ""source_assertion"": ""Rhea lists CHEBI:15379 on the substrates side of RHEA:25877 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25877']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25877"", ""source_version"": ""139"", ""title"": ""Rhea iminosuccinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25877""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-002_145610ac3840	CHEBI:29991	pathwaymech:consumes	RHEA:25877	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25877		"[{""reference_id"": ""RHEA:25877"", ""source_assertion"": ""Rhea lists CHEBI:29991 on the substrates side of RHEA:25877 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25877']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25877"", ""source_version"": ""139"", ""title"": ""Rhea iminosuccinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25877""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-003_18b3350cb737	RHEA:25877	pathwaymech:produces	CHEBI:16240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25877		"[{""reference_id"": ""RHEA:25877"", ""source_assertion"": ""Rhea lists CHEBI:16240 on the products side of RHEA:25877 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25877']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25877"", ""source_version"": ""139"", ""title"": ""Rhea iminosuccinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25877""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-004_85878db8aaca	RHEA:25877	pathwaymech:produces	CHEBI:77875	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25877		"[{""reference_id"": ""RHEA:25877"", ""source_assertion"": ""Rhea lists CHEBI:77875 on the products side of RHEA:25877 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25877']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25877"", ""source_version"": ""139"", ""title"": ""Rhea iminosuccinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25877""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-005_a05da357743d	CHEBI:57642	pathwaymech:consumes	RHEA:25889	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25889		"[{""reference_id"": ""RHEA:25889"", ""source_assertion"": ""Rhea lists CHEBI:57642 on the substrates side of RHEA:25889 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25889']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25889"", ""source_version"": ""139"", ""title"": ""Rhea quinolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25889""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-006_da7d55efad4f	CHEBI:77875	pathwaymech:consumes	RHEA:25889	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25889		"[{""reference_id"": ""RHEA:25889"", ""source_assertion"": ""Rhea lists CHEBI:77875 on the substrates side of RHEA:25889 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25889']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25889"", ""source_version"": ""139"", ""title"": ""Rhea quinolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25889""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-007_dd7d944201a1	RHEA:25889	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25889		"[{""reference_id"": ""RHEA:25889"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:25889 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25889']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25889"", ""source_version"": ""139"", ""title"": ""Rhea quinolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25889""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-008_464be3a16eb8	RHEA:25889	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25889		"[{""reference_id"": ""RHEA:25889"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:25889 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25889']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25889"", ""source_version"": ""139"", ""title"": ""Rhea quinolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25889""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-009_36657e42db32	RHEA:25889	pathwaymech:produces	CHEBI:29959	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25889		"[{""reference_id"": ""RHEA:25889"", ""source_assertion"": ""Rhea lists CHEBI:29959 on the products side of RHEA:25889 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25889']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25889"", ""source_version"": ""139"", ""title"": ""Rhea quinolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25889""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-010_26b46f9161fa	RHEA:25889	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25889		"[{""reference_id"": ""RHEA:25889"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:25889 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25889']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25889"", ""source_version"": ""139"", ""title"": ""Rhea quinolinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25889""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-011_c854449ef388	CHEBI:15378	pathwaymech:consumes	RHEA:12735	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12735		"[{""reference_id"": ""RHEA:12735"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:12735 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12735']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12735"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate beta-D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12735""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-012_7222dc96f33f	CHEBI:29959	pathwaymech:consumes	RHEA:12735	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12735		"[{""reference_id"": ""RHEA:12735"", ""source_assertion"": ""Rhea lists CHEBI:29959 on the substrates side of RHEA:12735 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12735']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12735"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate beta-D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12735""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-013_56ba55769d27	CHEBI:58017	pathwaymech:consumes	RHEA:12735	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12735		"[{""reference_id"": ""RHEA:12735"", ""source_assertion"": ""Rhea lists CHEBI:58017 on the substrates side of RHEA:12735 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12735']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12735"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate beta-D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12735""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-014_b721312ceeb9	RHEA:12735	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12735		"[{""reference_id"": ""RHEA:12735"", ""source_assertion"": ""Rhea lists CHEBI:16526 on the products side of RHEA:12735 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12735']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12735"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate beta-D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12735""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-015_be4c53e172b1	RHEA:12735	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12735		"[{""reference_id"": ""RHEA:12735"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:12735 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12735']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12735"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate beta-D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12735""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-016_04783367c4ac	RHEA:12735	pathwaymech:produces	CHEBI:57502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12735		"[{""reference_id"": ""RHEA:12735"", ""source_assertion"": ""Rhea lists CHEBI:57502 on the products side of RHEA:12735 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12735']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12735"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate beta-D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12735""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-017_e4f4949be595	CHEBI:15378	pathwaymech:consumes	RHEA:22861	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22861		"[{""reference_id"": ""RHEA:22861"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:22861 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22861']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22861"", ""source_version"": ""139"", ""title"": ""Rhea deamido-NAD-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22861""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-018_ef842deef45d	CHEBI:30616	pathwaymech:consumes	RHEA:22861	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22861		"[{""reference_id"": ""RHEA:22861"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:22861 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22861']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22861"", ""source_version"": ""139"", ""title"": ""Rhea deamido-NAD-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22861""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-019_366b2e0d0931	CHEBI:57502	pathwaymech:consumes	RHEA:22861	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22861		"[{""reference_id"": ""RHEA:22861"", ""source_assertion"": ""Rhea lists CHEBI:57502 on the substrates side of RHEA:22861 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22861']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22861"", ""source_version"": ""139"", ""title"": ""Rhea deamido-NAD-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22861""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-020_a5708127fe9c	RHEA:22861	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22861		"[{""reference_id"": ""RHEA:22861"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:22861 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22861']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22861"", ""source_version"": ""139"", ""title"": ""Rhea deamido-NAD-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22861""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-021_a727cfe74422	RHEA:22861	pathwaymech:produces	CHEBI:58437	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22861		"[{""reference_id"": ""RHEA:22861"", ""source_assertion"": ""Rhea lists CHEBI:58437 on the products side of RHEA:22861 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22861']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22861"", ""source_version"": ""139"", ""title"": ""Rhea deamido-NAD-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22861""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-022_81223eacad80	CHEBI:28938	pathwaymech:consumes	RHEA:21189	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21189		"[{""reference_id"": ""RHEA:21189"", ""source_assertion"": ""Rhea lists CHEBI:28938 on the substrates side of RHEA:21189 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21189']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21189"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming ammonia-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/21189""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-023_2d3780283c80	CHEBI:30616	pathwaymech:consumes	RHEA:21189	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21189		"[{""reference_id"": ""RHEA:21189"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:21189 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21189']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21189"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming ammonia-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/21189""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-024_04490dd70a33	CHEBI:58437	pathwaymech:consumes	RHEA:21189	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21189		"[{""reference_id"": ""RHEA:21189"", ""source_assertion"": ""Rhea lists CHEBI:58437 on the substrates side of RHEA:21189 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21189']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21189"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming ammonia-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/21189""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-025_379545cd181e	RHEA:21189	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21189		"[{""reference_id"": ""RHEA:21189"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:21189 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21189']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21189"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming ammonia-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/21189""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-026_408ad9cf2a37	RHEA:21189	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21189		"[{""reference_id"": ""RHEA:21189"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:21189 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21189']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21189"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming ammonia-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/21189""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-027_a3a5b72d5dc9	RHEA:21189	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21189		"[{""reference_id"": ""RHEA:21189"", ""source_assertion"": ""Rhea lists CHEBI:456215 on the products side of RHEA:21189 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21189']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21189"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming ammonia-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/21189""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-028_1f677ad1e489	RHEA:21189	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21189		"[{""reference_id"": ""RHEA:21189"", ""source_assertion"": ""Rhea lists CHEBI:57540 on the products side of RHEA:21189 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21189']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:21189"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming ammonia-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/21189""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-029_47830fa92a48	CHEBI:15377	pathwaymech:consumes	RHEA:24385	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24385		"[{""reference_id"": ""RHEA:24385"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:24385 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24385']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24385"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming glutamine-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/24385""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-030_9a06055798b9	CHEBI:30616	pathwaymech:consumes	RHEA:24385	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24385		"[{""reference_id"": ""RHEA:24385"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:24385 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24385']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24385"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming glutamine-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/24385""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-031_d35560897fe4	CHEBI:58359	pathwaymech:consumes	RHEA:24385	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24385		"[{""reference_id"": ""RHEA:24385"", ""source_assertion"": ""Rhea lists CHEBI:58359 on the substrates side of RHEA:24385 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24385']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24385"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming glutamine-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/24385""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-032_95f71b096834	CHEBI:58437	pathwaymech:consumes	RHEA:24385	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24385		"[{""reference_id"": ""RHEA:24385"", ""source_assertion"": ""Rhea lists CHEBI:58437 on the substrates side of RHEA:24385 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24385']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24385"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming glutamine-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/24385""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-033_da9bb39d13fa	RHEA:24385	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24385		"[{""reference_id"": ""RHEA:24385"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:24385 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24385']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24385"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming glutamine-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/24385""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-034_802b862b5e8d	RHEA:24385	pathwaymech:produces	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24385		"[{""reference_id"": ""RHEA:24385"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the products side of RHEA:24385 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24385']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24385"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming glutamine-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/24385""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-035_0a849ace3e86	RHEA:24385	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24385		"[{""reference_id"": ""RHEA:24385"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:24385 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24385']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24385"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming glutamine-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/24385""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-036_1724a19386b1	RHEA:24385	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24385		"[{""reference_id"": ""RHEA:24385"", ""source_assertion"": ""Rhea lists CHEBI:456215 on the products side of RHEA:24385 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24385']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24385"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming glutamine-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/24385""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-037_56cc138ebb4b	RHEA:24385	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24385		"[{""reference_id"": ""RHEA:24385"", ""source_assertion"": ""Rhea lists CHEBI:57540 on the products side of RHEA:24385 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24385']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24385"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming glutamine-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/24385""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-038_43783542d2b2	EC:1.4.3.16	pathwaymech:catalyzes	RHEA:25877	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25876		"[{""reference_id"": ""RHEA:25876"", ""source_assertion"": ""Rhea associates EC:1.4.3.16 with the reaction family containing RHEA:25877."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:25876"", ""source_version"": ""139"", ""title"": ""Rhea L-aspartate oxidase reaction"", ""url"": ""https://www.rhea-db.org/rhea/25876""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-039_4e69db756c95	EC:2.5.1.72	pathwaymech:catalyzes	RHEA:25889	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25888		"[{""reference_id"": ""RHEA:25888"", ""source_assertion"": ""Rhea associates EC:2.5.1.72 with the reaction family containing RHEA:25889."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:25888"", ""source_version"": ""139"", ""title"": ""Rhea quinolinate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/25888""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-040_1348e5bd5d44	EC:2.4.2.19	pathwaymech:catalyzes	RHEA:12735	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12733		"[{""reference_id"": ""RHEA:12733"", ""source_assertion"": ""Rhea associates EC:2.4.2.19 with the reaction family containing RHEA:12735."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:12733"", ""source_version"": ""139"", ""title"": ""Rhea quinolinate phosphoribosyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/12733""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-041_fa28c25766f4	EC:2.7.7.18	pathwaymech:catalyzes	RHEA:22861	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22860		"[{""reference_id"": ""RHEA:22860"", ""source_assertion"": ""Rhea associates EC:2.7.7.18 with the reaction family containing RHEA:22861."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:22860"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate-nucleotide adenylyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/22860""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-042_f9a73eaabfb2	EC:6.3.1.5	pathwaymech:catalyzes	RHEA:21189	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21188		"[{""reference_id"": ""RHEA:21188"", ""source_assertion"": ""Rhea associates EC:6.3.1.5 with the reaction family containing RHEA:21189."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:21188"", ""source_version"": ""139"", ""title"": ""Rhea ammonia-dependent NAD synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/21188""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-043_cf9d7084418b	EC:6.3.5.1	pathwaymech:catalyzes	RHEA:24385	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24384		"[{""reference_id"": ""RHEA:24384"", ""source_assertion"": ""Rhea associates EC:6.3.5.1 with the reaction family containing RHEA:24385."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:24384"", ""source_version"": ""139"", ""title"": ""Rhea glutamine-dependent NAD synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/24384""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-044_6f8ea3a78b12	RHEA:12735	pathwaymech:precedes	RHEA:22861	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PYRIDNUCSYN-PWY		"[{""reference_id"": ""MetaCyc:PYRIDNUCSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:12735 before RHEA:22861 in this pathway. Shared intermediate: CHEBI:57502."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PYRIDNUCSYN-PWY"", ""source_sha256"": ""30f2101c8309de3c581a8c7de456be41f82c0ead3a96cb6a06c8ee7acf119f29"", ""source_version"": ""22.5"", ""title"": ""MetaCyc NAD de novo biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PYRIDNUCSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-045_c4e23496af92	RHEA:22861	pathwaymech:precedes	RHEA:21189	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PYRIDNUCSYN-PWY		"[{""reference_id"": ""MetaCyc:PYRIDNUCSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:22861 before RHEA:21189 in this pathway. Shared intermediate: CHEBI:58437."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PYRIDNUCSYN-PWY"", ""source_sha256"": ""30f2101c8309de3c581a8c7de456be41f82c0ead3a96cb6a06c8ee7acf119f29"", ""source_version"": ""22.5"", ""title"": ""MetaCyc NAD de novo biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PYRIDNUCSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-046_8445d85b7108	RHEA:22861	pathwaymech:precedes	RHEA:24385	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PYRIDNUCSYN-PWY		"[{""reference_id"": ""MetaCyc:PYRIDNUCSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:22861 before RHEA:24385 in this pathway. Shared intermediate: CHEBI:58437."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PYRIDNUCSYN-PWY"", ""source_sha256"": ""30f2101c8309de3c581a8c7de456be41f82c0ead3a96cb6a06c8ee7acf119f29"", ""source_version"": ""22.5"", ""title"": ""MetaCyc NAD de novo biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PYRIDNUCSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-047_27b7634c4b81	RHEA:25877	pathwaymech:precedes	RHEA:25889	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PYRIDNUCSYN-PWY		"[{""reference_id"": ""MetaCyc:PYRIDNUCSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:25877 before RHEA:25889 in this pathway. Shared intermediate: CHEBI:77875."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PYRIDNUCSYN-PWY"", ""source_sha256"": ""30f2101c8309de3c581a8c7de456be41f82c0ead3a96cb6a06c8ee7acf119f29"", ""source_version"": ""22.5"", ""title"": ""MetaCyc NAD de novo biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PYRIDNUCSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSYN-PWY_edge-048_06a9c110e7d7	RHEA:25889	pathwaymech:precedes	RHEA:12735	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PYRIDNUCSYN-PWY		"[{""reference_id"": ""MetaCyc:PYRIDNUCSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:25889 before RHEA:12735 in this pathway. Shared intermediate: CHEBI:29959."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PYRIDNUCSYN-PWY"", ""source_sha256"": ""30f2101c8309de3c581a8c7de456be41f82c0ead3a96cb6a06c8ee7acf119f29"", ""source_version"": ""22.5"", ""title"": ""MetaCyc NAD de novo biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PYRIDNUCSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-001_ea3602f5fb97	CHEBI:15377	pathwaymech:consumes	RHEA:11801	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11801		"[{""reference_id"": ""RHEA:11801"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:11801 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11801']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11801"", ""source_version"": ""139"", ""title"": ""Rhea beta-nicotinamide D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/11801""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-002_2493ceaf6994	CHEBI:57540	pathwaymech:consumes	RHEA:11801	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11801		"[{""reference_id"": ""RHEA:11801"", ""source_assertion"": ""Rhea lists CHEBI:57540 on the substrates side of RHEA:11801 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11801']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11801"", ""source_version"": ""139"", ""title"": ""Rhea beta-nicotinamide D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/11801""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-003_1e0fa8bc6e36	RHEA:11801	pathwaymech:produces	CHEBI:14649	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11801		"[{""reference_id"": ""RHEA:11801"", ""source_assertion"": ""Rhea lists CHEBI:14649 on the products side of RHEA:11801 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11801']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11801"", ""source_version"": ""139"", ""title"": ""Rhea beta-nicotinamide D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/11801""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-004_ba7ea49e2a26	RHEA:11801	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11801		"[{""reference_id"": ""RHEA:11801"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:11801 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11801']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11801"", ""source_version"": ""139"", ""title"": ""Rhea beta-nicotinamide D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/11801""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-005_2299608f38c7	RHEA:11801	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11801		"[{""reference_id"": ""RHEA:11801"", ""source_assertion"": ""Rhea lists CHEBI:456215 on the products side of RHEA:11801 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11801']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11801"", ""source_version"": ""139"", ""title"": ""Rhea beta-nicotinamide D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/11801""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-006_07d4ee6d31a9	CHEBI:14649	pathwaymech:consumes	RHEA:23141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23141		"[{""reference_id"": ""RHEA:23141"", ""source_assertion"": ""Rhea lists CHEBI:14649 on the substrates side of RHEA:23141 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23141']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23141"", ""source_version"": ""139"", ""title"": ""Rhea nicotinamide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23141""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-007_43cd114a6149	CHEBI:15377	pathwaymech:consumes	RHEA:23141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23141		"[{""reference_id"": ""RHEA:23141"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:23141 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23141']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23141"", ""source_version"": ""139"", ""title"": ""Rhea nicotinamide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23141""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-008_164182d8a66e	RHEA:23141	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23141		"[{""reference_id"": ""RHEA:23141"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:23141 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23141']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23141"", ""source_version"": ""139"", ""title"": ""Rhea nicotinamide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23141""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-009_606b96db5628	RHEA:23141	pathwaymech:produces	CHEBI:17154	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23141		"[{""reference_id"": ""RHEA:23141"", ""source_assertion"": ""Rhea lists CHEBI:17154 on the products side of RHEA:23141 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23141']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23141"", ""source_version"": ""139"", ""title"": ""Rhea nicotinamide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23141""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-010_08aac206bd00	RHEA:23141	pathwaymech:produces	CHEBI:78346	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23141		"[{""reference_id"": ""RHEA:23141"", ""source_assertion"": ""Rhea lists CHEBI:78346 on the products side of RHEA:23141 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23141']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23141"", ""source_version"": ""139"", ""title"": ""Rhea nicotinamide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/23141""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-011_b54f57cdf481	CHEBI:15377	pathwaymech:consumes	RHEA:14546	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14546		"[{""reference_id"": ""RHEA:14546"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:14546 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14546']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14546"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14546""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-012_61e0613051bc	CHEBI:17154	pathwaymech:consumes	RHEA:14546	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14546		"[{""reference_id"": ""RHEA:14546"", ""source_assertion"": ""Rhea lists CHEBI:17154 on the substrates side of RHEA:14546 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14546']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14546"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14546""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-013_d2c446b168e5	RHEA:14546	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14546		"[{""reference_id"": ""RHEA:14546"", ""source_assertion"": ""Rhea lists CHEBI:28938 on the products side of RHEA:14546 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14546']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14546"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14546""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-014_ce9f19303a57	RHEA:14546	pathwaymech:produces	CHEBI:32544	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14546		"[{""reference_id"": ""RHEA:14546"", ""source_assertion"": ""Rhea lists CHEBI:32544 on the products side of RHEA:14546 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14546']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14546"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/14546""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-015_5cf359fa02e6	CHEBI:15377	pathwaymech:consumes	RHEA:36164	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:36164		"[{""reference_id"": ""RHEA:36164"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:36164 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/36164']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:36164"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate beta-D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/36164""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-016_b24dc9b000be	CHEBI:30616	pathwaymech:consumes	RHEA:36164	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:36164		"[{""reference_id"": ""RHEA:36164"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:36164 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/36164']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:36164"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate beta-D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/36164""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-017_33b43e19ffab	CHEBI:32544	pathwaymech:consumes	RHEA:36164	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:36164		"[{""reference_id"": ""RHEA:36164"", ""source_assertion"": ""Rhea lists CHEBI:32544 on the substrates side of RHEA:36164 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/36164']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:36164"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate beta-D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/36164""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-018_a6ab7febc847	CHEBI:58017	pathwaymech:consumes	RHEA:36164	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:36164		"[{""reference_id"": ""RHEA:36164"", ""source_assertion"": ""Rhea lists CHEBI:58017 on the substrates side of RHEA:36164 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/36164']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:36164"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate beta-D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/36164""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-019_d982605e897c	RHEA:36164	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:36164		"[{""reference_id"": ""RHEA:36164"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:36164 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/36164']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:36164"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate beta-D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/36164""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-020_c82c2cc4895c	RHEA:36164	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:36164		"[{""reference_id"": ""RHEA:36164"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:36164 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/36164']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:36164"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate beta-D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/36164""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-021_71296bf57a20	RHEA:36164	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:36164		"[{""reference_id"": ""RHEA:36164"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:36164 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/36164']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:36164"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate beta-D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/36164""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-022_d6158dab4a33	RHEA:36164	pathwaymech:produces	CHEBI:57502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:36164		"[{""reference_id"": ""RHEA:36164"", ""source_assertion"": ""Rhea lists CHEBI:57502 on the products side of RHEA:36164 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/36164']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:36164"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate beta-D-ribonucleotide-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/36164""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-023_d9b385daf3d5	CHEBI:15378	pathwaymech:consumes	RHEA:22861	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22861		"[{""reference_id"": ""RHEA:22861"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:22861 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22861']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22861"", ""source_version"": ""139"", ""title"": ""Rhea deamido-NAD-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22861""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-024_e9346af956ab	CHEBI:30616	pathwaymech:consumes	RHEA:22861	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22861		"[{""reference_id"": ""RHEA:22861"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:22861 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22861']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22861"", ""source_version"": ""139"", ""title"": ""Rhea deamido-NAD-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22861""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-025_e802c78b22f8	CHEBI:57502	pathwaymech:consumes	RHEA:22861	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22861		"[{""reference_id"": ""RHEA:22861"", ""source_assertion"": ""Rhea lists CHEBI:57502 on the substrates side of RHEA:22861 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22861']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22861"", ""source_version"": ""139"", ""title"": ""Rhea deamido-NAD-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22861""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-026_2d65c7973456	RHEA:22861	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22861		"[{""reference_id"": ""RHEA:22861"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:22861 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22861']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22861"", ""source_version"": ""139"", ""title"": ""Rhea deamido-NAD-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22861""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-027_bee7ed6dbd7e	RHEA:22861	pathwaymech:produces	CHEBI:58437	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22861		"[{""reference_id"": ""RHEA:22861"", ""source_assertion"": ""Rhea lists CHEBI:58437 on the products side of RHEA:22861 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22861']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22861"", ""source_version"": ""139"", ""title"": ""Rhea deamido-NAD-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22861""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-028_742973d3e309	CHEBI:15377	pathwaymech:consumes	RHEA:24385	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24385		"[{""reference_id"": ""RHEA:24385"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:24385 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24385']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24385"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming glutamine-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/24385""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-029_cf2702aac8cd	CHEBI:30616	pathwaymech:consumes	RHEA:24385	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24385		"[{""reference_id"": ""RHEA:24385"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:24385 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24385']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24385"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming glutamine-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/24385""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-030_7c3f6f6930a1	CHEBI:58359	pathwaymech:consumes	RHEA:24385	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24385		"[{""reference_id"": ""RHEA:24385"", ""source_assertion"": ""Rhea lists CHEBI:58359 on the substrates side of RHEA:24385 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24385']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24385"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming glutamine-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/24385""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-031_117d18eaf6b0	CHEBI:58437	pathwaymech:consumes	RHEA:24385	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24385		"[{""reference_id"": ""RHEA:24385"", ""source_assertion"": ""Rhea lists CHEBI:58437 on the substrates side of RHEA:24385 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24385']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24385"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming glutamine-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/24385""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-032_c0d2c087e6e5	RHEA:24385	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24385		"[{""reference_id"": ""RHEA:24385"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:24385 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24385']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24385"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming glutamine-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/24385""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-033_52492f6e268b	RHEA:24385	pathwaymech:produces	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24385		"[{""reference_id"": ""RHEA:24385"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the products side of RHEA:24385 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24385']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24385"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming glutamine-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/24385""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-034_3a11b0b79362	RHEA:24385	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24385		"[{""reference_id"": ""RHEA:24385"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:24385 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24385']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24385"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming glutamine-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/24385""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-035_75fa6ea060a0	RHEA:24385	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24385		"[{""reference_id"": ""RHEA:24385"", ""source_assertion"": ""Rhea lists CHEBI:456215 on the products side of RHEA:24385 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24385']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24385"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming glutamine-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/24385""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-036_2214a4f2140a	RHEA:24385	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24385		"[{""reference_id"": ""RHEA:24385"", ""source_assertion"": ""Rhea lists CHEBI:57540 on the products side of RHEA:24385 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24385']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24385"", ""source_version"": ""139"", ""title"": ""Rhea NAD-forming glutamine-dependent direction"", ""url"": ""https://www.rhea-db.org/rhea/24385""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-037_6bafafd68884	EC:3.6.1.22	pathwaymech:catalyzes	RHEA:11801	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11800		"[{""reference_id"": ""RHEA:11800"", ""source_assertion"": ""Rhea associates EC:3.6.1.22 with the reaction family containing RHEA:11801."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:11800"", ""source_version"": ""139"", ""title"": ""Rhea NAD(+) diphosphatase reaction"", ""url"": ""https://www.rhea-db.org/rhea/11800""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-038_f2499884a3d0	EC:3.2.2.14	pathwaymech:catalyzes	RHEA:23141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23140		"[{""reference_id"": ""RHEA:23140"", ""source_assertion"": ""Rhea associates EC:3.2.2.14 with the reaction family containing RHEA:23141."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:23140"", ""source_version"": ""139"", ""title"": ""Rhea NMN nucleosidase reaction"", ""url"": ""https://www.rhea-db.org/rhea/23140""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-039_6e66e1eaa624	EC:3.5.1.19	pathwaymech:catalyzes	RHEA:14546	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14545		"[{""reference_id"": ""RHEA:14545"", ""source_assertion"": ""Rhea associates EC:3.5.1.19 with the reaction family containing RHEA:14546."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:14545"", ""source_version"": ""139"", ""title"": ""Rhea nicotinamidase reaction"", ""url"": ""https://www.rhea-db.org/rhea/14545""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-040_678e8b92b48a	EC:6.3.4.21	pathwaymech:catalyzes	RHEA:36164	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:36163		"[{""reference_id"": ""RHEA:36163"", ""source_assertion"": ""Rhea associates EC:6.3.4.21 with the reaction family containing RHEA:36164."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:36163"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate phosphoribosyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/36163""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-041_d1a5eefa36f8	EC:2.7.7.18	pathwaymech:catalyzes	RHEA:22861	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22860		"[{""reference_id"": ""RHEA:22860"", ""source_assertion"": ""Rhea associates EC:2.7.7.18 with the reaction family containing RHEA:22861."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:22860"", ""source_version"": ""139"", ""title"": ""Rhea nicotinate-nucleotide adenylyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/22860""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-042_b59a126e260c	EC:6.3.5.1	pathwaymech:catalyzes	RHEA:24385	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24384		"[{""reference_id"": ""RHEA:24384"", ""source_assertion"": ""Rhea associates EC:6.3.5.1 with the reaction family containing RHEA:24385."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:24384"", ""source_version"": ""139"", ""title"": ""Rhea glutamine-dependent NAD synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/24384""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-043_280d0c9d87c6	RHEA:11801	pathwaymech:precedes	RHEA:23141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PYRIDNUCSAL-PWY		"[{""reference_id"": ""MetaCyc:PYRIDNUCSAL-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:11801 before RHEA:23141 in this pathway. Shared intermediate: CHEBI:14649."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PYRIDNUCSAL-PWY"", ""source_sha256"": ""d562d66abb786b6a9507a7e638d4be13ab2550e4c777f52c109248a81167cc02"", ""source_version"": ""22.5"", ""title"": ""MetaCyc NAD salvage pathway I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PYRIDNUCSAL-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-044_c3262ead0730	RHEA:14546	pathwaymech:precedes	RHEA:36164	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PYRIDNUCSAL-PWY		"[{""reference_id"": ""MetaCyc:PYRIDNUCSAL-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:14546 before RHEA:36164 in this pathway. Shared intermediate: CHEBI:32544."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PYRIDNUCSAL-PWY"", ""source_sha256"": ""d562d66abb786b6a9507a7e638d4be13ab2550e4c777f52c109248a81167cc02"", ""source_version"": ""22.5"", ""title"": ""MetaCyc NAD salvage pathway I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PYRIDNUCSAL-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-045_cce8ab5a8d75	RHEA:22861	pathwaymech:precedes	RHEA:24385	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PYRIDNUCSAL-PWY		"[{""reference_id"": ""MetaCyc:PYRIDNUCSAL-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:22861 before RHEA:24385 in this pathway. Shared intermediate: CHEBI:58437."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PYRIDNUCSAL-PWY"", ""source_sha256"": ""d562d66abb786b6a9507a7e638d4be13ab2550e4c777f52c109248a81167cc02"", ""source_version"": ""22.5"", ""title"": ""MetaCyc NAD salvage pathway I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PYRIDNUCSAL-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-046_b4c8369686d7	RHEA:23141	pathwaymech:precedes	RHEA:14546	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PYRIDNUCSAL-PWY		"[{""reference_id"": ""MetaCyc:PYRIDNUCSAL-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:23141 before RHEA:14546 in this pathway. Shared intermediate: CHEBI:17154."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PYRIDNUCSAL-PWY"", ""source_sha256"": ""d562d66abb786b6a9507a7e638d4be13ab2550e4c777f52c109248a81167cc02"", ""source_version"": ""22.5"", ""title"": ""MetaCyc NAD salvage pathway I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PYRIDNUCSAL-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-047_b3be0d1c1457	RHEA:24385	pathwaymech:precedes	RHEA:11801	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PYRIDNUCSAL-PWY		"[{""reference_id"": ""MetaCyc:PYRIDNUCSAL-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:24385 before RHEA:11801 in this pathway. The source ordering may bridge anomer-specific and broader substrate classes."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PYRIDNUCSAL-PWY"", ""source_sha256"": ""d562d66abb786b6a9507a7e638d4be13ab2550e4c777f52c109248a81167cc02"", ""source_version"": ""22.5"", ""title"": ""MetaCyc NAD salvage pathway I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PYRIDNUCSAL-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PYRIDNUCSAL-PWY_edge-048_860ae4be53d3	RHEA:36164	pathwaymech:precedes	RHEA:22861	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PYRIDNUCSAL-PWY		"[{""reference_id"": ""MetaCyc:PYRIDNUCSAL-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:36164 before RHEA:22861 in this pathway. Shared intermediate: CHEBI:57502."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PYRIDNUCSAL-PWY"", ""source_sha256"": ""d562d66abb786b6a9507a7e638d4be13ab2550e4c777f52c109248a81167cc02"", ""source_version"": ""22.5"", ""title"": ""MetaCyc NAD salvage pathway I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PYRIDNUCSAL-PWY&detail=full""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-001_e1fda57f6fe8	gomodel:RIBOSYLNICOTINAMIDE-KINASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:RIBOSYLNICOTINAMIDE-KINASE-RXN RO:0002234 gomodel:CHEBI_15378_RIBOSYLNICOTINAMIDE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/0; endpoint types: /individuals/10/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-002_b36c292cd1b7	gomodel:2.7.7.1-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:2.7.7.1-RXN RO:0002233 gomodel:CHEBI_15378_2.7.7.1-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/1; endpoint types: /individuals/28/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-003_c3323a793b5f	gomodel:2.7.7.1-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:2.7.7.1-RXN BFO:0000066 gomodel:reaction_2.7.7.1-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/2; endpoint types: /individuals/28/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-004_7152d6fdadc2	gomodel:YeastPathways_PWY3O-4106/6a46ef0600000917	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4106/6a46ef0600000917 RO:0002233 gomodel:YeastPathways_PWY3O-4106/6a46ef0600000918."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/3; endpoint types: /individuals/30/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-005_30bef944e6ed	gomodel:2.7.7.1-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:2.7.7.1-RXN RO:0002234 gomodel:CHEBI_29888_2.7.7.1-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/4; endpoint types: /individuals/28/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-006_f4b2498a5164	gomodel:RIBOSYLNICOTINAMIDE-KINASE-RXN	RO:0002234	CHEBI:14649	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:RIBOSYLNICOTINAMIDE-KINASE-RXN RO:0002234 gomodel:CHEBI_14649_RIBOSYLNICOTINAMIDE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/5; endpoint types: /individuals/10/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-007_62ba6ad28030	SGD:S000005073	pathwaymech:enables	gomodel:RIBOSYLNICOTINAMIDE-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:RIBOSYLNICOTINAMIDE-KINASE-RXN RO:0002333 gomodel:MONOMER3O-4139_RIBOSYLNICOTINAMIDE-KINASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/6; endpoint types: /individuals/10/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-008_a5c0ca5c425b	gomodel:2.7.7.1-RXN	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:2.7.7.1-RXN RO:0002234 gomodel:CHEBI_57540_2.7.7.1-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/7; endpoint types: /individuals/28/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-009_e9d5d1420140	gomodel:RIBOSYLNICOTINAMIDE-KINASE-RXN	RO:0002233	CHEBI:15927	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:RIBOSYLNICOTINAMIDE-KINASE-RXN RO:0002233 gomodel:CHEBI_15927_RIBOSYLNICOTINAMIDE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/8; endpoint types: /individuals/10/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-010_d6166a5989c8	gomodel:YeastPathways_PWY3O-4106/6a46ef0600000917	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4106/6a46ef0600000917 RO:0002233 gomodel:YeastPathways_PWY3O-4106/6a46ef0600000919."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/9; endpoint types: /individuals/30/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-011_8e0bb555f142	SGD:S000004320	pathwaymech:enables	gomodel:2.7.7.1-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:2.7.7.1-RXN RO:0002333 gomodel:YLR328W-MONOMER_2.7.7.1-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/10; endpoint types: /individuals/28/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-012_98271b3da07a	gomodel:2.7.7.1-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:2.7.7.1-RXN RO:0002233 gomodel:CHEBI_30616_2.7.7.1-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/11; endpoint types: /individuals/28/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-014_121659b7b12e	gomodel:RIBOSYLNICOTINAMIDE-KINASE-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:RIBOSYLNICOTINAMIDE-KINASE-RXN RO:0002233 gomodel:CHEBI_30616_RIBOSYLNICOTINAMIDE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/13; endpoint types: /individuals/10/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-015_9500acaf6b1f	gomodel:RIBOSYLNICOTINAMIDE-KINASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:RIBOSYLNICOTINAMIDE-KINASE-RXN BFO:0000066 gomodel:reaction_RIBOSYLNICOTINAMIDE-KINASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/14; endpoint types: /individuals/10/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-016_296cc823ecd0	gomodel:YeastPathways_PWY3O-4106/6a46ef0600000917	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4106/6a46ef0600000917 RO:0002234 gomodel:YeastPathways_PWY3O-4106/6a46ef0600000921."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/15; endpoint types: /individuals/30/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-017_17f49b8396ec	gomodel:YeastPathways_PWY3O-4106/6a46ef0600000917	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4106/6a46ef0600000917 RO:0002234 gomodel:YeastPathways_PWY3O-4106/6a46ef0600000920."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/16; endpoint types: /individuals/30/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-018_b14966017d10	gomodel:YeastPathways_PWY3O-4106/6a46ef0600000917	RO:0002233	CHEBI:14649	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4106/6a46ef0600000917 RO:0002233 gomodel:CHEBI_14649_RIBOSYLNICOTINAMIDE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/17; endpoint types: /individuals/30/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-019_5affc41989d5	gomodel:2.7.7.1-RXN	BFO:0000050	GO:0034355	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:2.7.7.1-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4106/YeastPathways_PWY3O-4106."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/18; endpoint types: /individuals/28/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-020_6b087ec99a98	gomodel:RIBOSYLNICOTINAMIDE-KINASE-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:RIBOSYLNICOTINAMIDE-KINASE-RXN RO:0002234 gomodel:CHEBI_456216_RIBOSYLNICOTINAMIDE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/19; endpoint types: /individuals/10/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-021_790a08b20293	gomodel:RIBOSYLNICOTINAMIDE-KINASE-RXN	BFO:0000050	GO:0034355	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:RIBOSYLNICOTINAMIDE-KINASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4106/YeastPathways_PWY3O-4106."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/20; endpoint types: /individuals/10/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-022_2b9b8b902b6f	SGD:S000003242	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4106/6a46ef0600000917	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4106/6a46ef0600000917 RO:0002333 gomodel:YeastPathways_PWY3O-4106/6a46ef0600000923."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/21; endpoint types: /individuals/30/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-023_1738869b3559	gomodel:2.7.7.1-RXN	RO:0002233	CHEBI:14649	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:2.7.7.1-RXN RO:0002233 gomodel:CHEBI_14649_RIBOSYLNICOTINAMIDE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/22; endpoint types: /individuals/28/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_edge-024_dc3b2e3897ba	gomodel:YeastPathways_PWY3O-4106/6a46ef0600000917	BFO:0000050	GO:0034355	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4106		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4106/6a46ef0600000917 BFO:0000050 gomodel:YeastPathways_PWY3O-4106/YeastPathways_PWY3O-4106."", ""source_locator"": ""./YeastPathways_PWY3O-4106.json#/facts/23; endpoint types: /individuals/30/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4106"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4106.json"", ""title"": ""SGD GO-CAM NAD salvage pathway IV (from nicotinamide riboside) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_location-468dc09ff1ce_f45e0766cc20	SGD:S000004320	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06178	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q06178"", ""source_assertion"": ""UniProtKB:Q06178 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2726/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q06178"", ""source_assertion"": ""UniProtKB:Q06178 has the exact SGD cross-reference SGD:S000004320."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2726/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q06178"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06178 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_location-cd3f40d8ca41_f83927619b1d	SGD:S000004320	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06178	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q06178"", ""source_assertion"": ""UniProtKB:Q06178 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2726/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q06178"", ""source_assertion"": ""UniProtKB:Q06178 has the exact SGD cross-reference SGD:S000004320."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2726/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q06178"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06178 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_location-e5c3511bf090_9739696916a7	SGD:S000003242	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53204	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11884393)	"[{""reference_id"": ""UniProtKB:P53204"", ""source_assertion"": ""UniProtKB:P53204 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2159/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53204"", ""source_assertion"": ""UniProtKB:P53204 has the exact SGD cross-reference SGD:S000003242."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2159/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53204"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53204 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_cofactor-def4425deb9f_5640137a730f	SGD:S000004320	pathwaymech:has_cofactor	CHEBI:49786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06178	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10428462) Divalent metal cation. UniProt note evidence: ECO:0000269 (PubMed:10428462)	"[{""reference_id"": ""UniProtKB:Q06178"", ""source_assertion"": ""UniProtKB:Q06178 annotates CHEBI:49786 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2726/comments/0/cofactors/0; /results/2726/comments/0/note""}, {""reference_id"": ""UniProtKB:Q06178"", ""source_assertion"": ""UniProtKB:Q06178 has the exact SGD cross-reference SGD:S000004320."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2726/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q06178"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06178 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4106_cofactor-d2f2e51cfdb3_824996fd0caf	SGD:S000003242	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53204	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:12597897) Divalent metal cation. UniProt note evidence: ECO:0000269 (PubMed:12597897)	"[{""reference_id"": ""UniProtKB:P53204"", ""source_assertion"": ""UniProtKB:P53204 annotates CHEBI:48828 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2159/comments/0/cofactors/0; /results/2159/comments/0/note""}, {""reference_id"": ""UniProtKB:P53204"", ""source_assertion"": ""UniProtKB:P53204 has the exact SGD cross-reference SGD:S000003242."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2159/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53204"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53204 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-1_7f3ebfce924c	CHEBI:17154	pathwaymech:consumes	WikiPathways:WP171/id4b00dac6	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id4b00dac6 connects normalized CHEBI:17154 as an input of interaction id4b00dac6."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id4b00dac6']/Graphics; /Pathway/DataNode[@GraphId='d1d']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-2_cf804fd60645	WikiPathways:WP171/id4b00dac6	pathwaymech:produces	CHEBI:32544	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id4b00dac6 connects normalized CHEBI:32544 as an output of interaction id4b00dac6."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id4b00dac6']/Graphics; /Pathway/DataNode[@GraphId='dd772']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-3_6178bb8deffe	CHEBI:58437	pathwaymech:consumes	WikiPathways:WP171/id58e1978f	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id58e1978f connects normalized CHEBI:58437 as an input of interaction id58e1978f."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id58e1978f']/Graphics; /Pathway/DataNode[@GraphId='c5365']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-4_d559fa5329e1	WikiPathways:WP171/id58e1978f	pathwaymech:produces	CHEBI:15846	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id58e1978f connects normalized CHEBI:15846 as an output of interaction id58e1978f."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id58e1978f']/Graphics; /Pathway/DataNode[@GraphId='dc20f']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-5_2d9938ea388c	WikiPathways:WP171/id5b2236e7	pathwaymech:produces	CHEBI:58437	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id5b2236e7 connects normalized CHEBI:58437 as an output of interaction id5b2236e7."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5b2236e7']/Graphics; /Pathway/DataNode[@GraphId='c5365']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-6_7e834e18d836	CHEBI:57502	pathwaymech:consumes	WikiPathways:WP171/id5b2236e7	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id5b2236e7 connects normalized CHEBI:57502 as an input of interaction id5b2236e7."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5b2236e7']/Graphics; /Pathway/DataNode[@GraphId='d3af6']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-7_070178d4f865	CHEBI:32544	pathwaymech:consumes	WikiPathways:WP171/ide26ea2c3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML ide26ea2c3 connects normalized CHEBI:32544 as an input of interaction ide26ea2c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ide26ea2c3']/Graphics; /Pathway/DataNode[@GraphId='dd772']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-8_1ef26de3dcad	WikiPathways:WP171/ide26ea2c3	pathwaymech:produces	CHEBI:57502	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML ide26ea2c3 connects normalized CHEBI:57502 as an output of interaction ide26ea2c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ide26ea2c3']/Graphics; /Pathway/DataNode[@GraphId='d3af6']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-9_d7360d35216f	CHEBI:15846	pathwaymech:consumes	WikiPathways:WP171/idfac03b17	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML idfac03b17 connects normalized CHEBI:15846 as an input of interaction idfac03b17."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idfac03b17']/Graphics; /Pathway/DataNode[@GraphId='dc20f']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-10_4677315b998b	WikiPathways:WP171/idfac03b17	pathwaymech:produces	CHEBI:17154	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML idfac03b17 connects normalized CHEBI:17154 as an output of interaction idfac03b17."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idfac03b17']/Graphics; /Pathway/DataNode[@GraphId='d1d']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-11_091c3c9804c3	SGD:S000002200	pathwaymech:catalyzes	WikiPathways:WP171/idfac03b17	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id163e27f0 connects normalized SGD:S000002200 as a catalyst of interaction idfac03b17."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id163e27f0']/Graphics; /Pathway/DataNode[@GraphId='ccc28']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-12_0a84fe9fa2ed	CHEBI:15377	pathwaymech:consumes	WikiPathways:WP171/ide26ea2c3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id281439dd connects normalized CHEBI:15377 as an input of interaction ide26ea2c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id281439dd']/Graphics; /Pathway/DataNode[@GraphId='d44']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-13_8d41a8f72a9d	CHEBI:58017	pathwaymech:consumes	WikiPathways:WP171/ide26ea2c3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id281439dd connects normalized CHEBI:58017 as an input of interaction ide26ea2c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id281439dd']/Graphics; /Pathway/DataNode[@GraphId='e33']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-14_d8b02661e69f	CHEBI:30616	pathwaymech:consumes	WikiPathways:WP171/ide26ea2c3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id281439dd connects normalized CHEBI:30616 as an input of interaction ide26ea2c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id281439dd']/Graphics; /Pathway/DataNode[@GraphId='f6f']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-15_5d4523b94177	WikiPathways:WP171/ide26ea2c3	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id2d1dd000 connects normalized CHEBI:456216 as an output of interaction ide26ea2c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id2d1dd000']/Graphics; /Pathway/DataNode[@GraphId='a4d']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-16_1185aa0f0a56	WikiPathways:WP171/ide26ea2c3	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id2d1dd000 connects normalized CHEBI:33019 as an output of interaction ide26ea2c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id2d1dd000']/Graphics; /Pathway/DataNode[@GraphId='b8c']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-17_0e58eda4c0ab	WikiPathways:WP171/ide26ea2c3	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id2d1dd000 connects normalized CHEBI:43474 as an output of interaction ide26ea2c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id2d1dd000']/Graphics; /Pathway/DataNode[@GraphId='f29']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-18_da382d79b51b	SGD:S000003005	pathwaymech:catalyzes	WikiPathways:WP171/id4b00dac6	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id32f0a3f9 connects normalized SGD:S000003005 as a catalyst of interaction id4b00dac6."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id32f0a3f9']/Graphics; /Pathway/DataNode[@GraphId='be0']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-19_1dc468629a4c	WikiPathways:WP171/id4b00dac6	pathwaymech:produces	CHEBI:16134	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id3b06e24 connects normalized CHEBI:16134 as an output of interaction id4b00dac6."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id3b06e24']/Graphics; /Pathway/DataNode[@GraphId='d8e']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-20_97c9ef7458db	WikiPathways:WP171/idfac03b17	pathwaymech:produces	CHEBI:83767	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id3b401140 connects normalized CHEBI:83767 as an output of interaction idfac03b17."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id3b401140']/Graphics; /Pathway/DataNode[@GraphId='e89b1']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-21_815b21e08dc9	WikiPathways:WP171/idfac03b17	pathwaymech:produces	CHEBI:29967	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id3b401140 connects normalized CHEBI:29967 as an output of interaction idfac03b17."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id3b401140']/Graphics; /Pathway/DataNode[@GraphId='fbed5']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-22_6234cdc8de05	WikiPathways:WP171/id58e1978f	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id492d684f connects normalized CHEBI:456215 as an output of interaction id58e1978f."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id492d684f']/Graphics; /Pathway/DataNode[@GraphId='a8b']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-23_30ccfe8f1ecd	WikiPathways:WP171/id58e1978f	pathwaymech:produces	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id492d684f connects normalized CHEBI:29985 as an output of interaction id58e1978f."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id492d684f']/Graphics; /Pathway/DataNode[@GraphId='dcf']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-24_b67e4cadbbfd	WikiPathways:WP171/id58e1978f	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id492d684f connects normalized CHEBI:33019 as an output of interaction id58e1978f."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id492d684f']/Graphics; /Pathway/DataNode[@GraphId='ae062']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-25_000ff5f50b92	WikiPathways:WP171/id58e1978f	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id492d684f connects normalized CHEBI:15378 as an output of interaction id58e1978f."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id492d684f']/Graphics; /Pathway/DataNode[@GraphId='a7470']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-26_2e470bbb7c23	SGD:S000005735	pathwaymech:catalyzes	WikiPathways:WP171/ide26ea2c3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id503ead connects normalized SGD:S000005735 as a catalyst of interaction ide26ea2c3."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id503ead']/Graphics; /Pathway/DataNode[@GraphId='b46']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-27_3f728a941bdd	CHEBI:15378	pathwaymech:consumes	WikiPathways:WP171/id5b2236e7	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id515f4de5 connects normalized CHEBI:15378 as an input of interaction id5b2236e7."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id515f4de5']/Graphics; /Pathway/DataNode[@GraphId='bda45']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-28_35968aa48189	CHEBI:30616	pathwaymech:consumes	WikiPathways:WP171/id5b2236e7	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id515f4de5 connects normalized CHEBI:30616 as an input of interaction id5b2236e7."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id515f4de5']/Graphics; /Pathway/DataNode[@GraphId='dba6f']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-29_c82a2f63ddd2	CHEBI:15377	pathwaymech:consumes	WikiPathways:WP171/id58e1978f	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id5c00a7af connects normalized CHEBI:15377 as an input of interaction id58e1978f."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5c00a7af']/Graphics; /Pathway/DataNode[@GraphId='e99']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-30_f05369bd09bd	CHEBI:30616	pathwaymech:consumes	WikiPathways:WP171/id58e1978f	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id5c00a7af connects normalized CHEBI:30616 as an input of interaction id58e1978f."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5c00a7af']/Graphics; /Pathway/DataNode[@GraphId='d8269']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-31_3d3e84f75295	CHEBI:58359	pathwaymech:consumes	WikiPathways:WP171/id58e1978f	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id5c00a7af connects normalized CHEBI:58359 as an input of interaction id58e1978f."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5c00a7af']/Graphics; /Pathway/DataNode[@GraphId='ec262']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-32_fa0439ccf634	CHEBI:15377	pathwaymech:consumes	WikiPathways:WP171/id4b00dac6	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id5df52837 connects normalized CHEBI:15377 as an input of interaction id4b00dac6."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5df52837']/Graphics; /Pathway/DataNode[@GraphId='bfb']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-33_2531e8d6dfbf	CHEBI:15377	pathwaymech:consumes	WikiPathways:WP171/idfac03b17	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id5e896944 connects normalized CHEBI:15377 as an input of interaction idfac03b17."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5e896944']/Graphics; /Pathway/DataNode[@GraphId='d7d']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-34_88f772a4e60c	CHEBI:61930	pathwaymech:consumes	WikiPathways:WP171/idfac03b17	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id5e896944 connects normalized CHEBI:61930 as an input of interaction idfac03b17."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5e896944']/Graphics; /Pathway/DataNode[@GraphId='a42ba']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-35_b4db6bb7d03c	SGD:S000001116	pathwaymech:catalyzes	WikiPathways:WP171/id58e1978f	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id88c19e21 connects normalized SGD:S000001116 as a catalyst of interaction id58e1978f."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id88c19e21']/Graphics; /Pathway/DataNode[@GraphId='d67']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-36_86a8ac09b892	SGD:S000004320	pathwaymech:catalyzes	WikiPathways:WP171/id5b2236e7	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id90fd8be connects normalized SGD:S000004320 as a catalyst of interaction id5b2236e7."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id90fd8be']/Graphics; /Pathway/DataNode[@GraphId='e3b']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-37_aec7057b75e9	SGD:S000003242	pathwaymech:catalyzes	WikiPathways:WP171/id5b2236e7	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML id90fd8be connects normalized SGD:S000003242 as a catalyst of interaction id5b2236e7."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id90fd8be']/Graphics; /Pathway/DataNode[@GraphId='e71']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_causal-review-38_367a71fddb4a	WikiPathways:WP171/id5b2236e7	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP171		"[{""reference_id"": ""WikiPathways:WP171"", ""source_assertion"": ""GPML idb811c195 connects normalized CHEBI:33019 as an output of interaction id5b2236e7."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idb811c195']/Graphics; /Pathway/DataNode[@GraphId='dc83f']""}]"	"[{""id"": ""WikiPathways:WP171"", ""source_sha256"": ""53114cc90a910dfe005edb5ffa7e12d88b5be1bc43850b11f98d4b71a1c731b9"", ""source_version"": ""WP171_r20260911170213"", ""title"": ""WP171 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP171/WP171.gpml""}]"	""
pathwaymech:WikiPathways_WP171_cofactor-def4425deb9f_2a6c47279c32	SGD:S000004320	pathwaymech:has_cofactor	CHEBI:49786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06178	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10428462) Divalent metal cation. UniProt note evidence: ECO:0000269 (PubMed:10428462)	"[{""reference_id"": ""UniProtKB:Q06178"", ""source_assertion"": ""UniProtKB:Q06178 annotates CHEBI:49786 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2726/comments/0/cofactors/0; /results/2726/comments/0/note""}, {""reference_id"": ""UniProtKB:Q06178"", ""source_assertion"": ""UniProtKB:Q06178 has the exact SGD cross-reference SGD:S000004320."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2726/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q06178"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB Q06178 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP171_cofactor-d2f2e51cfdb3_a6b27997b17d	SGD:S000003242	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53204	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:12597897) Divalent metal cation. UniProt note evidence: ECO:0000269 (PubMed:12597897)	"[{""reference_id"": ""UniProtKB:P53204"", ""source_assertion"": ""UniProtKB:P53204 annotates CHEBI:48828 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2159/comments/0/cofactors/0; /results/2159/comments/0/note""}, {""reference_id"": ""UniProtKB:P53204"", ""source_assertion"": ""UniProtKB:P53204 has the exact SGD cross-reference SGD:S000003242."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2159/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53204"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P53204 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP171_cofactor-93c3365a3d22_2a79ee376fde	SGD:S000002200	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06700	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: Historical ADP-ribosyltransferase assignment does not negate the directly evidenced SIR2 zinc annotation. UniProt evidence: ECO:0000269 (PubMed:23307867) Binds 1 zinc ion per subunit. UniProt note evidence: ECO:0000269 (PubMed:23307867)	"[{""reference_id"": ""UniProtKB:P06700"", ""source_assertion"": ""UniProtKB:P06700 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/136/comments/0/cofactors/0; /results/136/comments/0/note""}, {""reference_id"": ""UniProtKB:P06700"", ""source_assertion"": ""UniProtKB:P06700 has the exact SGD cross-reference SGD:S000002200."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/136/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P06700"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P06700 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-001_991a1b1c8a0c	CHEBI:30780	pathwaymech:consumes	RHEA:13170	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13170		"[{""reference_id"": ""RHEA:13170"", ""source_assertion"": ""RHEA:13170 substrates contain CHEBI:30780 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13170']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13169_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13169_compound_2303']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_13169_compound_2303']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_2303']/rh:accession""}]"	"[{""id"": ""RHEA:13170"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 13170"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-002_b41e8d667e51	RHEA:13170	pathwaymech:produces	CHEBI:29806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13170		"[{""reference_id"": ""RHEA:13170"", ""source_assertion"": ""RHEA:13170 products contain CHEBI:29806 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13170']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13169_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13169_compound_3031']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_13169_compound_3031']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3031']/rh:accession""}]"	"[{""id"": ""RHEA:13170"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 13170"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-003_b51c63cdc0b7	CHEBI:57706	pathwaymech:consumes	RHEA:13214	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13214		"[{""reference_id"": ""RHEA:13214"", ""source_assertion"": ""RHEA:13214 substrates contain CHEBI:57706 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13214']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13213_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13213_compound_4279']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_13213_compound_4279']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_4279']/rh:accession""}]"	"[{""id"": ""RHEA:13214"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 13214"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-004_54dc0b3ce6ba	CHEBI:58349	pathwaymech:consumes	RHEA:13214	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13214		"[{""reference_id"": ""RHEA:13214"", ""source_assertion"": ""RHEA:13214 substrates contain CHEBI:58349 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13214']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13213_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13213_compound_5188']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_13213_compound_5188']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_5188']/rh:accession""}]"	"[{""id"": ""RHEA:13214"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 13214"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-005_8379ebc16cd9	CHEBI:15377	pathwaymech:consumes	RHEA:13214	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13214		"[{""reference_id"": ""RHEA:13214"", ""source_assertion"": ""RHEA:13214 substrates contain CHEBI:15377 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13214']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13213_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13213_compound_1283']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_13213_compound_1283']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_1283']/rh:accession""}]"	"[{""id"": ""RHEA:13214"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 13214"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-006_8d981c31bd59	RHEA:13214	pathwaymech:produces	CHEBI:30031	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13214		"[{""reference_id"": ""RHEA:13214"", ""source_assertion"": ""RHEA:13214 products contain CHEBI:30031 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13214']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13213_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13213_compound_2501']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_13213_compound_2501']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_2501']/rh:accession""}]"	"[{""id"": ""RHEA:13214"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 13214"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-007_8063de51ca29	RHEA:13214	pathwaymech:produces	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13214		"[{""reference_id"": ""RHEA:13214"", ""source_assertion"": ""RHEA:13214 products contain CHEBI:57783 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13214']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13213_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13213_compound_3438']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_13213_compound_3438']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3438']/rh:accession""}]"	"[{""id"": ""RHEA:13214"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 13214"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-008_1969bc9f87b5	RHEA:13214	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13214		"[{""reference_id"": ""RHEA:13214"", ""source_assertion"": ""RHEA:13214 products contain CHEBI:15378 with coefficient 2. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13214']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13213_R']/rh:contains2[@rdf:resource='http://rdf.rhea-db.org/Participant_13213_compound_3249']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_13213_compound_3249']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3249']/rh:accession""}]"	"[{""id"": ""RHEA:13214"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 13214"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-009_b9ee8f56228d	CHEBI:16146	pathwaymech:consumes	RHEA:27386	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27386		"[{""reference_id"": ""RHEA:27386"", ""source_assertion"": ""RHEA:27386 substrates contain CHEBI:16146 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27386']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27385_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27385_compound_3670']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_27385_compound_3670']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3670']/rh:accession""}]"	"[{""id"": ""RHEA:27386"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 27386"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-010_446f894945cb	CHEBI:15377	pathwaymech:consumes	RHEA:27386	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27386		"[{""reference_id"": ""RHEA:27386"", ""source_assertion"": ""RHEA:27386 substrates contain CHEBI:15377 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27386']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27385_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27385_compound_1283']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_27385_compound_1283']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_1283']/rh:accession""}]"	"[{""id"": ""RHEA:27386"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 27386"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-011_e70948bde16f	RHEA:27386	pathwaymech:produces	CHEBI:30780	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27386		"[{""reference_id"": ""RHEA:27386"", ""source_assertion"": ""RHEA:27386 products contain CHEBI:30780 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27386']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27385_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27385_compound_2303']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_27385_compound_2303']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_2303']/rh:accession""}]"	"[{""id"": ""RHEA:27386"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 27386"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-012_61f92d9fff9a	RHEA:27386	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27386		"[{""reference_id"": ""RHEA:27386"", ""source_assertion"": ""RHEA:27386 products contain CHEBI:28938 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27386']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27385_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27385_compound_1012']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_27385_compound_1012']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_1012']/rh:accession""}]"	"[{""id"": ""RHEA:27386"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 27386"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-013_3bd756bf3944	CHEBI:16364	pathwaymech:consumes	RHEA:27523	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27523		"[{""reference_id"": ""RHEA:27523"", ""source_assertion"": ""RHEA:27523 substrates contain CHEBI:16364 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27523']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27522_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27522_compound_3377']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_27522_compound_3377']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3377']/rh:accession""}]"	"[{""id"": ""RHEA:27523"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 27523"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-014_d60c572bd1ee	CHEBI:15379	pathwaymech:consumes	RHEA:27523	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27523		"[{""reference_id"": ""RHEA:27523"", ""source_assertion"": ""RHEA:27523 substrates contain CHEBI:15379 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27523']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27522_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27522_compound_1198']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_27522_compound_1198']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_1198']/rh:accession""}]"	"[{""id"": ""RHEA:27523"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 27523"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-015_88741cad7523	RHEA:27523	pathwaymech:produces	CHEBI:59911	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27523		"[{""reference_id"": ""RHEA:27523"", ""source_assertion"": ""RHEA:27523 products contain CHEBI:59911 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27523']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27522_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27522_compound_6228']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_27522_compound_6228']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_6228']/rh:accession""}]"	"[{""id"": ""RHEA:27523"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 27523"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-016_346344e87d78	RHEA:27523	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27523		"[{""reference_id"": ""RHEA:27523"", ""source_assertion"": ""RHEA:27523 products contain CHEBI:15378 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27523']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27522_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27522_compound_3249']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_27522_compound_3249']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3249']/rh:accession""}]"	"[{""id"": ""RHEA:27523"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 27523"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-017_b1c861dcfc2a	CHEBI:59911	pathwaymech:consumes	RHEA:30844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30844		"[{""reference_id"": ""RHEA:30844"", ""source_assertion"": ""RHEA:30844 substrates contain CHEBI:59911 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30844']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/30843_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_30843_compound_6228']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_30843_compound_6228']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_6228']/rh:accession""}]"	"[{""id"": ""RHEA:30844"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 30844"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-018_d23be7edae5a	CHEBI:15377	pathwaymech:consumes	RHEA:30844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30844		"[{""reference_id"": ""RHEA:30844"", ""source_assertion"": ""RHEA:30844 substrates contain CHEBI:15377 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30844']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/30843_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_30843_compound_1283']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_30843_compound_1283']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_1283']/rh:accession""}]"	"[{""id"": ""RHEA:30844"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 30844"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-019_49f1576c2c9f	RHEA:30844	pathwaymech:produces	CHEBI:16146	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30844		"[{""reference_id"": ""RHEA:30844"", ""source_assertion"": ""RHEA:30844 products contain CHEBI:16146 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30844']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/30843_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_30843_compound_3670']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_30843_compound_3670']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3670']/rh:accession""}]"	"[{""id"": ""RHEA:30844"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 30844"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-020_909eccd9ae6e	RHEA:30844	pathwaymech:produces	CHEBI:15740	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30844		"[{""reference_id"": ""RHEA:30844"", ""source_assertion"": ""RHEA:30844 products contain CHEBI:15740 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30844']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/30843_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_30843_compound_3001']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_30843_compound_3001']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3001']/rh:accession""}]"	"[{""id"": ""RHEA:30844"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 30844"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-021_7d7b847f49e5	RHEA:30844	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30844		"[{""reference_id"": ""RHEA:30844"", ""source_assertion"": ""RHEA:30844 products contain CHEBI:15378 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30844']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/30843_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_30843_compound_3249']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_30843_compound_3249']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3249']/rh:accession""}]"	"[{""id"": ""RHEA:30844"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 30844"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-022_0c30c6c6bd41	CHEBI:66893	pathwaymech:consumes	RHEA:33928	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33928		"[{""reference_id"": ""RHEA:33928"", ""source_assertion"": ""RHEA:33928 substrates contain CHEBI:66893 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33928']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/33927_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_33927_compound_7386']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_33927_compound_7386']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_7386']/rh:accession""}]"	"[{""id"": ""RHEA:33928"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 33928"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-023_07cfc3e89315	CHEBI:15379	pathwaymech:consumes	RHEA:33928	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33928		"[{""reference_id"": ""RHEA:33928"", ""source_assertion"": ""RHEA:33928 substrates contain CHEBI:15379 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33928']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/33927_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_33927_compound_1198']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_33927_compound_1198']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_1198']/rh:accession""}]"	"[{""id"": ""RHEA:33928"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 33928"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-024_b9b5fa40c12f	CHEBI:57945	pathwaymech:consumes	RHEA:33928	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33928		"[{""reference_id"": ""RHEA:33928"", ""source_assertion"": ""RHEA:33928 substrates contain CHEBI:57945 with coefficient 2. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33928']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/33927_L']/rh:contains2[@rdf:resource='http://rdf.rhea-db.org/Participant_33927_compound_1650']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_33927_compound_1650']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_1650']/rh:accession""}]"	"[{""id"": ""RHEA:33928"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 33928"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-025_50529c6ec9bf	CHEBI:15378	pathwaymech:consumes	RHEA:33928	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33928		"[{""reference_id"": ""RHEA:33928"", ""source_assertion"": ""RHEA:33928 substrates contain CHEBI:15378 with coefficient 2. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33928']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/33927_L']/rh:contains2[@rdf:resource='http://rdf.rhea-db.org/Participant_33927_compound_3249']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_33927_compound_3249']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3249']/rh:accession""}]"	"[{""id"": ""RHEA:33928"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 33928"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-026_15b1778d610c	RHEA:33928	pathwaymech:produces	CHEBI:16364	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33928		"[{""reference_id"": ""RHEA:33928"", ""source_assertion"": ""RHEA:33928 products contain CHEBI:16364 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33928']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/33927_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_33927_compound_3377']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_33927_compound_3377']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3377']/rh:accession""}]"	"[{""id"": ""RHEA:33928"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 33928"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-027_52583da02c63	RHEA:33928	pathwaymech:produces	CHEBI:57706	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33928		"[{""reference_id"": ""RHEA:33928"", ""source_assertion"": ""RHEA:33928 products contain CHEBI:57706 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33928']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/33927_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_33927_compound_4279']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_33927_compound_4279']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_4279']/rh:accession""}]"	"[{""id"": ""RHEA:33928"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 33928"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-028_3c51137eb4c4	RHEA:33928	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33928		"[{""reference_id"": ""RHEA:33928"", ""source_assertion"": ""RHEA:33928 products contain CHEBI:15377 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33928']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/33927_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_33927_compound_1283']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_33927_compound_1283']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_1283']/rh:accession""}]"	"[{""id"": ""RHEA:33928"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 33928"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-029_7727e5eb49b3	RHEA:33928	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33928		"[{""reference_id"": ""RHEA:33928"", ""source_assertion"": ""RHEA:33928 products contain CHEBI:57540 with coefficient 2. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33928']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/33927_R']/rh:contains2[@rdf:resource='http://rdf.rhea-db.org/Participant_33927_compound_3484']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_33927_compound_3484']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3484']/rh:accession""}]"	"[{""id"": ""RHEA:33928"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 33928"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-030_df965e360d1b	CHEBI:66879	pathwaymech:consumes	RHEA:34216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34216		"[{""reference_id"": ""RHEA:34216"", ""source_assertion"": ""RHEA:34216 substrates contain CHEBI:66879 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34216']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34215_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_34215_compound_7379']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_34215_compound_7379']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_7379']/rh:accession""}]"	"[{""id"": ""RHEA:34216"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 34216"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-031_9cf6ff99daae	CHEBI:58349	pathwaymech:consumes	RHEA:34216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34216		"[{""reference_id"": ""RHEA:34216"", ""source_assertion"": ""RHEA:34216 substrates contain CHEBI:58349 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34216']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34215_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_34215_compound_5188']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_34215_compound_5188']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_5188']/rh:accession""}]"	"[{""id"": ""RHEA:34216"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 34216"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-032_35cff9a13ece	CHEBI:15377	pathwaymech:consumes	RHEA:34216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34216		"[{""reference_id"": ""RHEA:34216"", ""source_assertion"": ""RHEA:34216 substrates contain CHEBI:15377 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34216']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34215_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_34215_compound_1283']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_34215_compound_1283']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_1283']/rh:accession""}]"	"[{""id"": ""RHEA:34216"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 34216"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-033_90babc8f13b3	RHEA:34216	pathwaymech:produces	CHEBI:66942	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34216		"[{""reference_id"": ""RHEA:34216"", ""source_assertion"": ""RHEA:34216 products contain CHEBI:66942 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34216']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34215_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_34215_compound_7458']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_34215_compound_7458']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_7458']/rh:accession""}]"	"[{""id"": ""RHEA:34216"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 34216"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-034_a6fbd4e08ac7	RHEA:34216	pathwaymech:produces	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34216		"[{""reference_id"": ""RHEA:34216"", ""source_assertion"": ""RHEA:34216 products contain CHEBI:57783 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34216']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34215_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_34215_compound_3438']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_34215_compound_3438']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3438']/rh:accession""}]"	"[{""id"": ""RHEA:34216"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 34216"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-035_21589796e976	RHEA:34216	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34216		"[{""reference_id"": ""RHEA:34216"", ""source_assertion"": ""RHEA:34216 products contain CHEBI:15378 with coefficient 2. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34216']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34215_R']/rh:contains2[@rdf:resource='http://rdf.rhea-db.org/Participant_34215_compound_3249']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_34215_compound_3249']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3249']/rh:accession""}]"	"[{""id"": ""RHEA:34216"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 34216"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-036_0d972e494f8b	CHEBI:59806	pathwaymech:consumes	RHEA:73656	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:73656		"[{""reference_id"": ""RHEA:73656"", ""source_assertion"": ""RHEA:73656 substrates contain CHEBI:59806 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/73656']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/73655_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_73655_compound_1764']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_73655_compound_1764']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_1764']/rh:accession""}]"	"[{""id"": ""RHEA:73656"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 73656"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-037_fcd3e228d3ed	RHEA-COMP:14399	pathwaymech:consumes	RHEA:73656	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:73656	Whole generic cytochrome c redox state. Two carrier molecules participate per nicotine or pseudooxynicotine turnover. The S16 realization is CycN; this is not a free iron reactant or a claim about every cytochrome c.	"[{""reference_id"": ""RHEA:73656"", ""source_assertion"": ""RHEA:73656 substrates contain RHEA-COMP:14399 with coefficient 2. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/73656']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/73655_L']/rh:contains2[@rdf:resource='http://rdf.rhea-db.org/Participant_73655_compound_14399']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_73655_compound_14399']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_14399']/rh:accession""}]"	"[{""id"": ""RHEA:73656"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 73656"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-038_d695a1c72612	RHEA:73656	pathwaymech:produces	CHEBI:190393	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:190393|RHEA:73656		"[{""reference_id"": ""RHEA:73656"", ""source_assertion"": ""RHEA:73656 products contain CHEBI:193521 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/73656']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/73655_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_73655_compound_18516']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_73655_compound_18516']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_18516']/rh:accession""}, {""reference_id"": ""CHEBI:190393"", ""source_assertion"": ""ChEBI193521 is deprecated and explicitly replaced by CHEBI190393;190393 retains193521 as an alternative ID and has the same C10H13N2 formula and +1 charge."", ""source_locator"": ""statements[subject=CHEBI:193521,predicate=IAO:0100001,object=CHEBI:190393]; statements[subject=CHEBI:190393,predicate=oio:hasAlternativeId,value=CHEBI:193521]; chemrof formula/charge""}]"	"[{""id"": ""CHEBI:190393"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI255; digest identifies uncompressed Semantic SQL database, not OWL source bytes"", ""title"": ""ChEBI255 explicit N-methylmyosmine replacement"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""RHEA:73656"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 73656"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-039_09961804db02	RHEA:73656	pathwaymech:produces	RHEA-COMP:10350	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:73656	Whole generic cytochrome c redox state. Two carrier molecules participate per nicotine or pseudooxynicotine turnover. The S16 realization is CycN; this is not a free iron reactant or a claim about every cytochrome c.	"[{""reference_id"": ""RHEA:73656"", ""source_assertion"": ""RHEA:73656 products contain RHEA-COMP:10350 with coefficient 2. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/73656']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/73655_R']/rh:contains2[@rdf:resource='http://rdf.rhea-db.org/Participant_73655_compound_10350']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_73655_compound_10350']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_10350']/rh:accession""}]"	"[{""id"": ""RHEA:73656"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 73656"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-040_0195bdc7ffc5	RHEA:73656	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:73656		"[{""reference_id"": ""RHEA:73656"", ""source_assertion"": ""RHEA:73656 products contain CHEBI:15378 with coefficient 2. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/73656']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/73655_R']/rh:contains2[@rdf:resource='http://rdf.rhea-db.org/Participant_73655_compound_3249']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_73655_compound_3249']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3249']/rh:accession""}]"	"[{""id"": ""RHEA:73656"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 73656"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-041_c0c6430fc964	CHEBI:66878	pathwaymech:consumes	RHEA:75352	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:75352		"[{""reference_id"": ""RHEA:75352"", ""source_assertion"": ""RHEA:75352 substrates contain CHEBI:66878 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/75352']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/75351_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_75351_compound_7380']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_75351_compound_7380']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_7380']/rh:accession""}]"	"[{""id"": ""RHEA:75352"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 75352"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-042_3e90b5782adc	CHEBI:15377	pathwaymech:consumes	RHEA:75352	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:75352		"[{""reference_id"": ""RHEA:75352"", ""source_assertion"": ""RHEA:75352 substrates contain CHEBI:15377 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/75352']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/75351_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_75351_compound_1283']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_75351_compound_1283']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_1283']/rh:accession""}]"	"[{""id"": ""RHEA:75352"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 75352"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-043_65fa86548bf6	RHEA-COMP:14399	pathwaymech:consumes	RHEA:75352	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:75352	Whole generic cytochrome c redox state. Two carrier molecules participate per nicotine or pseudooxynicotine turnover. The S16 realization is CycN; this is not a free iron reactant or a claim about every cytochrome c.	"[{""reference_id"": ""RHEA:75352"", ""source_assertion"": ""RHEA:75352 substrates contain RHEA-COMP:14399 with coefficient 2. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/75352']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/75351_L']/rh:contains2[@rdf:resource='http://rdf.rhea-db.org/Participant_75351_compound_14399']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_75351_compound_14399']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_14399']/rh:accession""}]"	"[{""id"": ""RHEA:75352"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 75352"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-044_d5a5a22a6a63	RHEA:75352	pathwaymech:produces	CHEBI:66879	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:75352		"[{""reference_id"": ""RHEA:75352"", ""source_assertion"": ""RHEA:75352 products contain CHEBI:66879 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/75352']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/75351_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_75351_compound_7379']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_75351_compound_7379']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_7379']/rh:accession""}]"	"[{""id"": ""RHEA:75352"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 75352"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-045_2eeab3dbcf15	RHEA:75352	pathwaymech:produces	CHEBI:59338	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:75352		"[{""reference_id"": ""RHEA:75352"", ""source_assertion"": ""RHEA:75352 products contain CHEBI:59338 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/75352']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/75351_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_75351_compound_4446']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_75351_compound_4446']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_4446']/rh:accession""}]"	"[{""id"": ""RHEA:75352"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 75352"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-046_b6955ebcecab	RHEA:75352	pathwaymech:produces	RHEA-COMP:10350	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:75352	Whole generic cytochrome c redox state. Two carrier molecules participate per nicotine or pseudooxynicotine turnover. The S16 realization is CycN; this is not a free iron reactant or a claim about every cytochrome c.	"[{""reference_id"": ""RHEA:75352"", ""source_assertion"": ""RHEA:75352 products contain RHEA-COMP:10350 with coefficient 2. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/75352']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/75351_R']/rh:contains2[@rdf:resource='http://rdf.rhea-db.org/Participant_75351_compound_10350']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_75351_compound_10350']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_10350']/rh:accession""}]"	"[{""id"": ""RHEA:75352"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 75352"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-047_86450a550277	RHEA:75352	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:75352		"[{""reference_id"": ""RHEA:75352"", ""source_assertion"": ""RHEA:75352 products contain CHEBI:15378 with coefficient 2. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/75352']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/75351_R']/rh:contains2[@rdf:resource='http://rdf.rhea-db.org/Participant_75351_compound_3249']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_75351_compound_3249']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3249']/rh:accession""}]"	"[{""id"": ""RHEA:75352"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 75352"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-048_02f44df1d9e6	CHEBI:190393	pathwaymech:consumes	RHEA:75416	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:190393|RHEA:75416		"[{""reference_id"": ""RHEA:75416"", ""source_assertion"": ""RHEA:75416 substrates contain CHEBI:193521 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/75416']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/75415_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_75415_compound_18516']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_75415_compound_18516']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_18516']/rh:accession""}, {""reference_id"": ""CHEBI:190393"", ""source_assertion"": ""ChEBI193521 is deprecated and explicitly replaced by CHEBI190393;190393 retains193521 as an alternative ID and has the same C10H13N2 formula and +1 charge."", ""source_locator"": ""statements[subject=CHEBI:193521,predicate=IAO:0100001,object=CHEBI:190393]; statements[subject=CHEBI:190393,predicate=oio:hasAlternativeId,value=CHEBI:193521]; chemrof formula/charge""}]"	"[{""id"": ""CHEBI:190393"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI255; digest identifies uncompressed Semantic SQL database, not OWL source bytes"", ""title"": ""ChEBI255 explicit N-methylmyosmine replacement"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""RHEA:75416"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 75416"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-049_75623ade01f1	CHEBI:15377	pathwaymech:consumes	RHEA:75416	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:75416		"[{""reference_id"": ""RHEA:75416"", ""source_assertion"": ""RHEA:75416 substrates contain CHEBI:15377 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/75416']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/75415_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_75415_compound_1283']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_75415_compound_1283']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_1283']/rh:accession""}]"	"[{""id"": ""RHEA:75416"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 75416"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-050_d58ac1ff026d	RHEA:75416	pathwaymech:produces	CHEBI:66878	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:75416		"[{""reference_id"": ""RHEA:75416"", ""source_assertion"": ""RHEA:75416 products contain CHEBI:66878 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/75416']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/75415_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_75415_compound_7380']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_75415_compound_7380']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_7380']/rh:accession""}]"	"[{""id"": ""RHEA:75416"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 75416"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-051_76f006e8ded9	CHEBI:66942	pathwaymech:consumes	MetaCyc:RXN-13082	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-14094|MetaCyc:RXN-13082		"[{""reference_id"": ""MetaCyc:RXN-13082"", ""source_assertion"": ""Native left participant CPD-14094 has coefficient 1 in Spm hydroxylation."", ""source_locator"": ""Reaction[@frameid='RXN-13082']/left/Compound[@frameid='CPD-14094']; ../coefficient (omitted coefficient denotes one)""}, {""reference_id"": ""MetaCyc:CPD-14094"", ""source_assertion"": ""The native compound cross-reference is CHEBI:66942; its displayed role is retained without assigning a physiological Spm electron-acceptor species."", ""source_locator"": ""Compound[@frameid='CPD-14094']/dblink[dblink-db='CHEBI']/dblink-oid; common-name""}]"	"[{""id"": ""MetaCyc:CPD-14094"", ""source_sha256"": ""7893f5aa16242a96d198c0f98430dc976de2c6bb793e6e19794e500441fe13c7"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc CPD-14094: 4-oxo-4-(3-pyridyl)-butanoate"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-14094""}, {""id"": ""MetaCyc:RXN-13082"", ""source_sha256"": ""135163b28080c248a0a5727db85b3926ea63fcb51d7ee6e563aa73e7d2340597"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc RXN-13082: RXN-13082"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-13082""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-052_23228811f083	CHEBI:15377	pathwaymech:consumes	MetaCyc:RXN-13082	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-13082		"[{""reference_id"": ""MetaCyc:RXN-13082"", ""source_assertion"": ""Native left participant WATER has coefficient 1 in Spm hydroxylation."", ""source_locator"": ""Reaction[@frameid='RXN-13082']/left/Compound[@frameid='WATER']; ../coefficient (omitted coefficient denotes one)""}]"	"[{""id"": ""MetaCyc:RXN-13082"", ""source_sha256"": ""135163b28080c248a0a5727db85b3926ea63fcb51d7ee6e563aa73e7d2340597"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc RXN-13082: RXN-13082"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-13082""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-053_e2c60eb2f096	CHEBI:15339	pathwaymech:consumes	MetaCyc:RXN-13082	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Acceptor|MetaCyc:RXN-13082	Generic acceptor pair from the native reaction. No specific redox partner, oxygen cosubstrate or measured carrier formula is inferred.	"[{""reference_id"": ""MetaCyc:RXN-13082"", ""source_assertion"": ""Native left participant Acceptor has coefficient 1 in Spm hydroxylation."", ""source_locator"": ""Reaction[@frameid='RXN-13082']/left/Compound[@frameid='Acceptor']; ../coefficient (omitted coefficient denotes one)""}, {""reference_id"": ""MetaCyc:Acceptor"", ""source_assertion"": ""The native compound cross-reference is CHEBI:15339; its displayed role is retained without assigning a physiological Spm electron-acceptor species."", ""source_locator"": ""Compound[@frameid='Acceptor']/dblink[dblink-db='CHEBI']/dblink-oid; common-name""}]"	"[{""id"": ""MetaCyc:Acceptor"", ""source_sha256"": ""ec1f3b9cc8b8fcc9615706ab317adc59d9117883ce6631a30b8c795f4a3fe19f"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc Acceptor: an oxidized electron acceptor"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Acceptor""}, {""id"": ""MetaCyc:RXN-13082"", ""source_sha256"": ""135163b28080c248a0a5727db85b3926ea63fcb51d7ee6e563aa73e7d2340597"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc RXN-13082: RXN-13082"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-13082""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-054_e85b2e8a1dce	MetaCyc:RXN-13082	pathwaymech:produces	CHEBI:66893	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-14096|MetaCyc:RXN-13082		"[{""reference_id"": ""MetaCyc:RXN-13082"", ""source_assertion"": ""Native right participant CPD-14096 has coefficient 1 in Spm hydroxylation."", ""source_locator"": ""Reaction[@frameid='RXN-13082']/right/Compound[@frameid='CPD-14096']; ../coefficient (omitted coefficient denotes one)""}, {""reference_id"": ""MetaCyc:CPD-14096"", ""source_assertion"": ""The native compound cross-reference is CHEBI:66893; its displayed role is retained without assigning a physiological Spm electron-acceptor species."", ""source_locator"": ""Compound[@frameid='CPD-14096']/dblink[dblink-db='CHEBI']/dblink-oid; common-name""}]"	"[{""id"": ""MetaCyc:CPD-14096"", ""source_sha256"": ""d3bc1645f7f10f06955c3bfb63ccf2da3266f36aab19f3cbc7dbe59aebc1b704"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc CPD-14096: 6-hydroxy-3-succinoyl-pyridine"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-14096""}, {""id"": ""MetaCyc:RXN-13082"", ""source_sha256"": ""135163b28080c248a0a5727db85b3926ea63fcb51d7ee6e563aa73e7d2340597"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc RXN-13082: RXN-13082"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-13082""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-055_80e79146339a	MetaCyc:RXN-13082	pathwaymech:produces	CHEBI:17499	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Donor-H2|MetaCyc:RXN-13082	Generic acceptor pair from the native reaction. No specific redox partner, oxygen cosubstrate or measured carrier formula is inferred.	"[{""reference_id"": ""MetaCyc:RXN-13082"", ""source_assertion"": ""Native right participant Donor-H2 has coefficient 1 in Spm hydroxylation."", ""source_locator"": ""Reaction[@frameid='RXN-13082']/right/Compound[@frameid='Donor-H2']; ../coefficient (omitted coefficient denotes one)""}, {""reference_id"": ""MetaCyc:Donor-H2"", ""source_assertion"": ""The native compound cross-reference is CHEBI:17499; its displayed role is retained without assigning a physiological Spm electron-acceptor species."", ""source_locator"": ""Compound[@frameid='Donor-H2']/dblink[dblink-db='CHEBI']/dblink-oid; common-name""}]"	"[{""id"": ""MetaCyc:Donor-H2"", ""source_sha256"": ""a2cad5be6b6ec96bc2fabaa2d1d7fbcf0ef6549b846dce6870dd0879ac2e7bb9"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc Donor-H2: a reduced electron acceptor"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Donor-H2""}, {""id"": ""MetaCyc:RXN-13082"", ""source_sha256"": ""135163b28080c248a0a5727db85b3926ea63fcb51d7ee6e563aa73e7d2340597"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc RXN-13082: RXN-13082"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-13082""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-056_aa5d0eb9bb91	UniProtKB:F8G0P2	pathwaymech:enables	RHEA:73656	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33432238|RHEA:73656|UniProtKB:F8G0P2	Functional assignment; NicA2 is reported as a monomer or homodimer under different solution conditions. This edge does not assert a fixed assembly or oxygen as the physiological electron acceptor.	"[{""reference_id"": ""PMID:33432238"", ""source_assertion"": ""Purified NicA2 transfers the two electrons from nicotine to two CycN molecules; S16 cycN deletion and complementation support the physiological partner."", ""source_locator"": ""PMC7904663 Results P12-P20; Fig.2-5; Methods P27""}, {""reference_id"": ""UniProtKB:F8G0P2"", ""source_assertion"": ""The current accession supplies this exact protein sequence and organism identity; reviewed status and source-specific annotations remain separate from the primary assay."", ""source_locator"": ""/primaryAccession; /entryType; /organism; /sequence; /uniProtKBCrossReferences""}, {""reference_id"": ""RHEA:73656"", ""source_assertion"": ""Rhea master 73655 explicitly has directed member 73656; the forward chemical equation and sides define this selected reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/73655']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/73656']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/73656']/rh:equation; rh:substrates; rh:products""}]"	"[{""id"": ""PMID:33432238"", ""source_sha256"": ""a2aed7a7d4d5202ecad0908dd77a87f73adc9edfce80547504cdc61e87d4ee2b"", ""source_version"": ""Complete primary JATS XML; relevant Results, Methods, figures and source accessions inspected"", ""title"": ""A cytochrome c is the natural electron acceptor for nicotine oxidoreductase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7904663/fullTextXML""}, {""id"": ""RHEA:73656"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 73656"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:F8G0P2"", ""source_sha256"": ""ebf487ac3b45c9804f5e74b7574b9efa4a98477c6f9fda1743b6b9185e8b449b"", ""source_version"": ""UniProt release 2026_03; entry version 57, sequence version 1"", ""title"": ""UniProtKB reviewed (Swiss-Prot) F8G0P2"", ""url"": ""https://rest.uniprot.org/uniprotkb/F8G0P2.json""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-057_ad6c2fa385ca	UniProtKB:F8G0P1	pathwaymech:enables	RHEA:75352	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:35835223|RHEA:75352|UniProtKB:F8G0P1	Functional assignment to the protein gene product. The primary study and current UniProt describe a homodimer, but no HZN6 oxidase complex is assigned to this S16 enzyme.	"[{""reference_id"": ""PMID:35835223"", ""source_assertion"": ""Pnao transfers electrons from pseudooxynicotine to CycN; S16 cycN deletion impairs growth on pseudooxynicotine and complementation restores it."", ""source_locator"": ""PMC9396064 Results p0045-p0050; Fig.5-6; Discussion p0110""}, {""reference_id"": ""UniProtKB:F8G0P1"", ""source_assertion"": ""The current accession supplies this exact protein sequence and organism identity; reviewed status and source-specific annotations remain separate from the primary assay."", ""source_locator"": ""/primaryAccession; /entryType; /organism; /sequence; /uniProtKBCrossReferences""}, {""reference_id"": ""RHEA:75352"", ""source_assertion"": ""Rhea master 75351 explicitly has directed member 75352; the forward chemical equation and sides define this selected reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/75351']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/75352']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/75352']/rh:equation; rh:substrates; rh:products""}]"	"[{""id"": ""PMID:35835223"", ""source_sha256"": ""d7c879b84237ffc553ad714d4a2d746bba878bb74f2d5476035d503d27281a89"", ""source_version"": ""Complete primary JATS XML; relevant Results, Methods, figures and source accessions inspected"", ""title"": ""The enzyme pseudooxynicotine amine oxidase from Pseudomonas putida S16 is not an oxidase, but a dehydrogenase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9396064/fullTextXML""}, {""id"": ""RHEA:75352"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 75352"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:F8G0P1"", ""source_sha256"": ""d6785536436f1b1889450c91375c7430f02340db443aa1252f9711b334f20590"", ""source_version"": ""UniProt release 2026_03; entry version 49, sequence version 1"", ""title"": ""UniProtKB reviewed (Swiss-Prot) F8G0P1"", ""url"": ""https://rest.uniprot.org/uniprotkb/F8G0P1.json""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-058_c830568af491	UniProtKB:F8G0M1	pathwaymech:enables	RHEA:27523	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:22530095|RHEA:27523|UniProtKB:F8G0M1	S16 primary enzyme assay supports function; the current UniProt entry is unreviewed. This edge does not assert an isolated monomer or transfer the N-9 hexamer to S16.	"[{""reference_id"": ""PMID:22530095"", ""source_assertion"": ""Purified S16 Hpo converts 2,5-dihydroxypyridine to N-formylmaleamate; Fe2+ increases activity and the product was identified by LC-MS."", ""source_locator"": ""PMC3332521 Results: Hpo; Fig.2 and Supplementary Fig.3; body paragraph ordinal5""}, {""reference_id"": ""UniProtKB:F8G0M1"", ""source_assertion"": ""The current accession supplies this exact protein sequence and organism identity; reviewed status and source-specific annotations remain separate from the primary assay."", ""source_locator"": ""/primaryAccession; /entryType; /organism; /sequence; /uniProtKBCrossReferences""}, {""reference_id"": ""RHEA:27523"", ""source_assertion"": ""Rhea master 27522 explicitly has directed member 27523; the forward chemical equation and sides define this selected reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27522']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/27523']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27523']/rh:equation; rh:substrates; rh:products""}]"	"[{""id"": ""PMID:22530095"", ""source_sha256"": ""3992e04ad2ee4a89a774dde2b148343b4de0fd8cf7fd82fa96541c71dcdb88ff"", ""source_version"": ""Complete primary JATS XML; relevant Results, Methods, figures and source accessions inspected"", ""title"": ""Genomic analysis of Pseudomonas putida: genes in a genome island are crucial for nicotine degradation"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3332521/fullTextXML""}, {""id"": ""RHEA:27523"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 27523"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:F8G0M1"", ""source_sha256"": ""e57e19733e4a86868519a9db9d03f65ba060a6ddaf3e8c333b4699a846eac942"", ""source_version"": ""UniProt release 2026_03; entry version 48, sequence version 1"", ""title"": ""UniProtKB unreviewed (TrEMBL) F8G0M1"", ""url"": ""https://rest.uniprot.org/uniprotkb/F8G0M1.json""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-059_e95e5b922e1d	UniProtKB:F8G0M2	pathwaymech:enables	RHEA:30844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:22530095|RHEA:30844|UniProtKB:F8G0M2	S16 primary assay and native source support function; the unreviewed sequence exactly matches ADN26550.1 in the study deposit GQ857548. Coupled-assay NAD is not assigned to Nfo.	"[{""reference_id"": ""PMID:22530095"", ""source_assertion"": ""Purified S16 Nfo releases formate from N-formylmaleamate in a coupled assay; the pathway yields maleamate."", ""source_locator"": ""PMC3332521 Results: Nfo, Ami, and Iso; Fig.3A-B; Discussion; body paragraphs7,17""}, {""reference_id"": ""UniProtKB:F8G0M2"", ""source_assertion"": ""The current accession supplies this exact protein sequence and organism identity; reviewed status and source-specific annotations remain separate from the primary assay."", ""source_locator"": ""/primaryAccession; /entryType; /organism; /sequence; /uniProtKBCrossReferences""}, {""reference_id"": ""RHEA:30844"", ""source_assertion"": ""Rhea master 30843 explicitly has directed member 30844; the forward chemical equation and sides define this selected reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30843']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/30844']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/30844']/rh:equation; rh:substrates; rh:products""}]"	"[{""id"": ""PMID:22530095"", ""source_sha256"": ""3992e04ad2ee4a89a774dde2b148343b4de0fd8cf7fd82fa96541c71dcdb88ff"", ""source_version"": ""Complete primary JATS XML; relevant Results, Methods, figures and source accessions inspected"", ""title"": ""Genomic analysis of Pseudomonas putida: genes in a genome island are crucial for nicotine degradation"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3332521/fullTextXML""}, {""id"": ""RHEA:30844"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 30844"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:F8G0M2"", ""source_sha256"": ""f5b8cf06f6f8b7047c8fa2eabd4387e2b19a05351a50c682cb2f046076acdfd2"", ""source_version"": ""UniProt release 2026_03; entry version 71, sequence version 1"", ""title"": ""UniProtKB unreviewed (TrEMBL) F8G0M2"", ""url"": ""https://rest.uniprot.org/uniprotkb/F8G0M2.json""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-060_ced6616438d2	UniProtKB:F8G0M0	pathwaymech:enables	RHEA:27386	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:22530095|RHEA:27386|UniProtKB:F8G0M0	S16 primary assay and native source support function; the unreviewed sequence exactly matches ADN26552.1 in GQ857548. Coupled-assay NADPH is not a pathway substrate for Ami.	"[{""reference_id"": ""PMID:22530095"", ""source_assertion"": ""Purified S16 Ami transforms maleamate to maleate and releases ammonium, measured by a coupled glutamate-dehydrogenase assay."", ""source_locator"": ""PMC3332521 Results: Nfo, Ami, and Iso; Fig.3A,C; body paragraphs7-8""}, {""reference_id"": ""UniProtKB:F8G0M0"", ""source_assertion"": ""The current accession supplies this exact protein sequence and organism identity; reviewed status and source-specific annotations remain separate from the primary assay."", ""source_locator"": ""/primaryAccession; /entryType; /organism; /sequence; /uniProtKBCrossReferences""}, {""reference_id"": ""RHEA:27386"", ""source_assertion"": ""Rhea master 27385 explicitly has directed member 27386; the forward chemical equation and sides define this selected reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27385']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/27386']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27386']/rh:equation; rh:substrates; rh:products""}]"	"[{""id"": ""PMID:22530095"", ""source_sha256"": ""3992e04ad2ee4a89a774dde2b148343b4de0fd8cf7fd82fa96541c71dcdb88ff"", ""source_version"": ""Complete primary JATS XML; relevant Results, Methods, figures and source accessions inspected"", ""title"": ""Genomic analysis of Pseudomonas putida: genes in a genome island are crucial for nicotine degradation"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3332521/fullTextXML""}, {""id"": ""RHEA:27386"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 27386"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:F8G0M0"", ""source_sha256"": ""166411ecda381c854a2901d4e84705682f3bb9d2318a3f858e48c0c96a9e966e"", ""source_version"": ""UniProt release 2026_03; entry version 69, sequence version 1"", ""title"": ""UniProtKB unreviewed (TrEMBL) F8G0M0"", ""url"": ""https://rest.uniprot.org/uniprotkb/F8G0M0.json""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-061_db4109ee935d	UniProtKB:F8G0M4	BFO:0000050	MetaCyc:CPLX-8439	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8439|MetaCyc:MONOMER-17159	Native homodimer membership: 2 identical subunits; does not imply independent subunit catalysis.	"[{""reference_id"": ""MetaCyc:CPLX-8439"", ""source_assertion"": ""Native S16 complex contains 2 copies of MONOMER-17159."", ""source_locator"": ""Protein[@frameid='CPLX-8439']/species; component[Protein/@frameid='MONOMER-17159']/coefficient""}, {""reference_id"": ""MetaCyc:MONOMER-17159"", ""source_assertion"": ""The native monomer has the UniProt unification accession F8G0M4."", ""source_locator"": ""Protein[@frameid='MONOMER-17159']/dblink[dblink-db='UNIPROT']/dblink-oid""}]"	"[{""id"": ""MetaCyc:CPLX-8439"", ""source_sha256"": ""c719524c0b70efa36407c44bcbd9f3a5435cc86eb6b8466f3314c47680c7b806"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc CPLX-8439: 6-hydroxy-3-succinoyl-pyridine hydroxylase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8439""}, {""id"": ""MetaCyc:MONOMER-17159"", ""source_sha256"": ""b541a91a99b192463d7cc04d5a4ae76cfffe72bfb408091577a6306f6eaf5f5a"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc MONOMER-17159: 6-hydroxy-3-succinoyl-pyridine hydroxylase monomer"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-17159""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-062_820910efc940	MetaCyc:CPLX-8439	pathwaymech:catalyzes	RHEA:33928	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8439|RHEA:33928|UniProtKB:F8G0M4	Selected forward pathway flux is represented. HspB source and current Rhea retain the unusual two-NADH equation.	"[{""reference_id"": ""MetaCyc:CPLX-8439"", ""source_assertion"": ""The native S16 frame reports a homodimer and links CPLX-8439 through ENZRXN-20030 to RXN-13081; the normalized equation is supported separately by current UniProt and Rhea."", ""source_locator"": ""Protein[@frameid='CPLX-8439']/component; species; comment; catalyzes/Enzymatic-Reaction[@frameid='ENZRXN-20030']/reaction/Reaction[@frameid='RXN-13081']""}, {""reference_id"": ""RHEA:33928"", ""source_assertion"": ""Rhea master 33927 explicitly has directed member 33928; the forward chemical equation and sides define this selected reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33927']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/33928']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/33928']/rh:equation; rh:substrates; rh:products""}, {""reference_id"": ""UniProtKB:F8G0M4"", ""source_assertion"": ""Reviewed HspB assigns RHEA:33927, with two NADH in the normalized reaction, and reports a homodimer."", ""source_locator"": ""/comments[commentType=CATALYTIC ACTIVITY]/reaction; /comments[commentType=SUBUNIT]""}]"	"[{""id"": ""MetaCyc:CPLX-8439"", ""source_sha256"": ""c719524c0b70efa36407c44bcbd9f3a5435cc86eb6b8466f3314c47680c7b806"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc CPLX-8439: 6-hydroxy-3-succinoyl-pyridine hydroxylase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8439""}, {""id"": ""RHEA:33928"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 33928"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:F8G0M4"", ""source_sha256"": ""84ceb1632d706ffdddae9428be5d8c694666342d9c0ece6ee901c206916d373c"", ""source_version"": ""UniProt release 2026_03; entry version 54, sequence version 1"", ""title"": ""UniProtKB reviewed (Swiss-Prot) F8G0M4"", ""url"": ""https://rest.uniprot.org/uniprotkb/F8G0M4.json""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-063_088e3058cfd4	UniProtKB:F8G0M3	BFO:0000050	MetaCyc:CPLX-8990	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8990|MetaCyc:MONOMER-19246	Native homodimer membership: 2 identical subunits; does not imply independent subunit catalysis.	"[{""reference_id"": ""MetaCyc:CPLX-8990"", ""source_assertion"": ""Native S16 complex contains 2 copies of MONOMER-19246."", ""source_locator"": ""Protein[@frameid='CPLX-8990']/species; component[Protein/@frameid='MONOMER-19246']/coefficient""}, {""reference_id"": ""MetaCyc:MONOMER-19246"", ""source_assertion"": ""The native monomer has the UniProt unification accession F8G0M3."", ""source_locator"": ""Protein[@frameid='MONOMER-19246']/dblink[dblink-db='UNIPROT']/dblink-oid""}]"	"[{""id"": ""MetaCyc:CPLX-8990"", ""source_sha256"": ""b8ca5eb428c93e795cac962ef5a27584c06f5cfe57bf77718eb2431913a752b1"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc CPLX-8990: maleate isomerase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8990""}, {""id"": ""MetaCyc:MONOMER-19246"", ""source_sha256"": ""db1c37666afd070605013a1b6fd743989a3627443d8b886916b12f426a626bc2"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc MONOMER-19246: maleate isomerase monomer"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-19246""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-064_eb40c2a6e67a	MetaCyc:CPLX-8990	pathwaymech:catalyzes	RHEA:13170	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8990|PMID:22530095|RHEA:13170	Selected forward pathway flux is represented. Native maleate isomerization is reversible; the primary assay used a thiol reagent, which is not asserted as an endogenous stoichiometric reactant.	"[{""reference_id"": ""MetaCyc:CPLX-8990"", ""source_assertion"": ""The native S16 enzyme description reports the complete biochemical reaction and homodimeric assembly."", ""source_locator"": ""Protein[@frameid='CPLX-8990']/comment; component; species""}, {""reference_id"": ""RHEA:13170"", ""source_assertion"": ""Rhea master 13169 explicitly has directed member 13170; the forward chemical equation and sides define this selected reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13169']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/13170']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13170']/rh:equation; rh:substrates; rh:products""}, {""reference_id"": ""PMID:22530095"", ""source_assertion"": ""Purified S16 Iso converts maleate to fumarate; HPLC and kinetic assays were performed in the presence of 1-thioglycerol."", ""source_locator"": ""PMC3332521 Results Nfo, Ami, and Iso; Fig.3E-F; Methods Determination of Iso activity (body paragraph26)""}]"	"[{""id"": ""MetaCyc:CPLX-8990"", ""source_sha256"": ""b8ca5eb428c93e795cac962ef5a27584c06f5cfe57bf77718eb2431913a752b1"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc CPLX-8990: maleate isomerase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8990""}, {""id"": ""PMID:22530095"", ""source_sha256"": ""3992e04ad2ee4a89a774dde2b148343b4de0fd8cf7fd82fa96541c71dcdb88ff"", ""source_version"": ""Complete primary JATS XML; relevant Results, Methods, figures and source accessions inspected"", ""title"": ""Genomic analysis of Pseudomonas putida: genes in a genome island are crucial for nicotine degradation"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3332521/fullTextXML""}, {""id"": ""RHEA:13170"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 13170"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-065_073f51218d80	MetaCyc:MONOMER-19251	BFO:0000050	MetaCyc:CPLX-8991	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8991|MetaCyc:MONOMER-19251	Source-defined three-subunit composition. The 2013 genetic/complementation evidence does not measure a purified native assembly stoichiometry.	"[{""reference_id"": ""MetaCyc:CPLX-8991"", ""source_assertion"": ""The native S16 complex lists one MONOMER-19251 component."", ""source_locator"": ""Protein[@frameid='CPLX-8991']/component[Protein/@frameid='MONOMER-19251']/coefficient; species""}, {""reference_id"": ""MetaCyc:MONOMER-19251"", ""source_assertion"": ""This exact native protein frame identifies the S16 Spm subunit."", ""source_locator"": ""Protein/species; common-name; gene""}]"	"[{""id"": ""MetaCyc:CPLX-8991"", ""source_sha256"": ""b26342249b25a942c82cccdd7bfa67b88d24a28578a1b95707826684dae7fb4d"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc CPLX-8991: 3-succinoylpyridine monooxygenase complex"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8991""}, {""id"": ""MetaCyc:MONOMER-19251"", ""source_sha256"": ""875e65ee6223c776966de36d4a3ad01b85f5ef46e5d8dab0fb27352800b11804"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc MONOMER-19251: 3-succinoylpyridine monooxygenase oxygenase subunit"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-19251""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-066_334179717e04	MetaCyc:MONOMER-19252	BFO:0000050	MetaCyc:CPLX-8991	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8991|MetaCyc:MONOMER-19252	Source-defined three-subunit composition. The 2013 genetic/complementation evidence does not measure a purified native assembly stoichiometry.	"[{""reference_id"": ""MetaCyc:CPLX-8991"", ""source_assertion"": ""The native S16 complex lists one MONOMER-19252 component."", ""source_locator"": ""Protein[@frameid='CPLX-8991']/component[Protein/@frameid='MONOMER-19252']/coefficient; species""}, {""reference_id"": ""MetaCyc:MONOMER-19252"", ""source_assertion"": ""This exact native protein frame identifies the S16 Spm subunit."", ""source_locator"": ""Protein/species; common-name; gene""}]"	"[{""id"": ""MetaCyc:CPLX-8991"", ""source_sha256"": ""b26342249b25a942c82cccdd7bfa67b88d24a28578a1b95707826684dae7fb4d"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc CPLX-8991: 3-succinoylpyridine monooxygenase complex"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8991""}, {""id"": ""MetaCyc:MONOMER-19252"", ""source_sha256"": ""0545f0466d42d40d9a38571b705c26808074c37440f7ce3f36f809d4a00fdf6c"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc MONOMER-19252: 3-succinoylpyridine monooxygenase ferredoxin dehydrogenase subunit"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-19252""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-067_fb964d028f1a	MetaCyc:MONOMER-19253	BFO:0000050	MetaCyc:CPLX-8991	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8991|MetaCyc:MONOMER-19253	Source-defined three-subunit composition. The 2013 genetic/complementation evidence does not measure a purified native assembly stoichiometry.	"[{""reference_id"": ""MetaCyc:CPLX-8991"", ""source_assertion"": ""The native S16 complex lists one MONOMER-19253 component."", ""source_locator"": ""Protein[@frameid='CPLX-8991']/component[Protein/@frameid='MONOMER-19253']/coefficient; species""}, {""reference_id"": ""MetaCyc:MONOMER-19253"", ""source_assertion"": ""This exact native protein frame identifies the S16 Spm subunit."", ""source_locator"": ""Protein/species; common-name; gene""}]"	"[{""id"": ""MetaCyc:CPLX-8991"", ""source_sha256"": ""b26342249b25a942c82cccdd7bfa67b88d24a28578a1b95707826684dae7fb4d"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc CPLX-8991: 3-succinoylpyridine monooxygenase complex"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8991""}, {""id"": ""MetaCyc:MONOMER-19253"", ""source_sha256"": ""2e4678acc871189cd037b376b4949b08a81adaef2c12ff23533f8e8f9aad240f"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc MONOMER-19253: 3-succinoylpyridine monooxygenase ferredoxin subunit"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-19253""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-068_f8deaeab16cf	MetaCyc:CPLX-8991	pathwaymech:enables	MetaCyc:RXN-13082	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-23743|PMID:24204321	Genetic/complementation assignment, not a claim that a purified SpmABC complex was kinetically characterized or its physiological electron acceptor identified.	"[{""reference_id"": ""PMID:24204321"", ""source_assertion"": ""S16 spmABC disruption prevents succinoylpyridine conversion; complementation restores hydroxylation to HSP and growth on nicotine."", ""source_locator"": ""PMC3812094 Results: Identification of the key enzyme responsible for SP hydroxylation; Fig.5; Discussion""}, {""reference_id"": ""MetaCyc:ENZRXN-23743"", ""source_assertion"": ""The native enzymatic reaction assigns CPLX-8991 to RXN-13082 with reaction-blocked-in-mutant evidence."", ""source_locator"": ""Enzymatic-Reaction/reaction; enzyme; evidence/Evidence-Code""}]"	"[{""id"": ""MetaCyc:ENZRXN-23743"", ""source_sha256"": ""af817cdd8f9dc880bbcd18e671fefb2f0f148df2ba80d91aeff799d01e3c20ca"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc ENZRXN-23743: 3-succinoylpyridine monooxygenase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-23743""}, {""id"": ""PMID:24204321"", ""source_sha256"": ""8e34eaa3e528e674a94ea47b9ef1cff68ce73b97e4a806d8544b13442734bfe0"", ""source_version"": ""Complete primary JATS XML; relevant Results, Methods, figures and source accessions inspected"", ""title"": ""Systematic Unraveling of the Unsolved Pathway of Nicotine Degradation in Pseudomonas\n"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3812094/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-069_7928b31329eb	RHEA:73656	RO:0002233	UniProtKB:A0A0E3ELC2	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.2210/pdb7TLX/pdb|NCBIProtein:WP_080563818.1|PMID:33432238|UniProtKB:A0A0E3ELC2	Concrete S16 protein realization of the generic cytochrome carrier in the chemical equation. This nonstoichiometric role edge adds no further molecule; no stable NicA2-CycN complex or downstream CycN oxidant is asserted.	"[{""reference_id"": ""PMID:33432238"", ""source_assertion"": ""S16 CycN is the experimentally supported physiological electron-accepting protein for this activity."", ""source_locator"": ""PMC7904663 Results P12-P20; Fig.2-5""}, {""reference_id"": ""UniProtKB:A0A0E3ELC2"", ""source_assertion"": ""The unreviewed entry has 132 amino acids and explicitly links WP_080563818.1 and PDB7TLX (residues28-132). Its merged taxon is303."", ""source_locator"": ""/sequence; /uniProtKBCrossReferences[database=RefSeq,id=WP_080563818.1]; /uniProtKBCrossReferences[database=PDB,id=7TLX]""}, {""reference_id"": ""DOI:10.2210/pdb7TLX/pdb"", ""source_assertion"": ""Entity1 is sourced from S16 (taxon1042876); its105-aa mature sequence and explicit SIFTS alignment match UniProt A0A0E3ELC2 residues28-132."", ""source_locator"": ""/entity_src_gen; /entity_poly/pdbx_seq_one_letter_code_can; /rcsb_polymer_entity_align""}, {""reference_id"": ""NCBIProtein:WP_080563818.1"", ""source_assertion"": ""The full132-aa RefSeq sequence is identical to A0A0E3ELC2 in the reproducible sequence comparison."", ""source_locator"": ""FASTA header WP_080563818.1; complete amino-acid sequence""}]"	"[{""id"": ""DOI:10.2210/pdb7TLX/pdb"", ""source_sha256"": ""df9fbc375a0032b3a2ca9fe86aedab26b0701cf51a68ebc2af714599bcc659b5"", ""source_version"": ""RCSB native author-deposited polymer-entity JSON; retrieved2026-10-11"", ""title"": ""PDB7TLX polymer entity1: S16 mature CycN sequence and source organism"", ""url"": ""https://data.rcsb.org/rest/v1/core/polymer_entity/7TLX/1""}, {""id"": ""NCBIProtein:WP_080563818.1"", ""source_sha256"": ""5a0a775fd06527e8870699bfb5a4517613c4c09533a274c07738f30e1088737f"", ""source_version"": ""Native FASTA retrieved2026-10-11; MULTISPECIES Pseudomonas designation"", ""title"": ""NCBI RefSeq WP_080563818.1 cytochrome c protein sequence"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=WP_080563818.1&rettype=fasta&retmode=text""}, {""id"": ""PMID:33432238"", ""source_sha256"": ""a2aed7a7d4d5202ecad0908dd77a87f73adc9edfce80547504cdc61e87d4ee2b"", ""source_version"": ""Complete primary JATS XML; relevant Results, Methods, figures and source accessions inspected"", ""title"": ""A cytochrome c is the natural electron acceptor for nicotine oxidoreductase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7904663/fullTextXML""}, {""id"": ""UniProtKB:A0A0E3ELC2"", ""source_sha256"": ""c283c70c8900d3f544dc096a4a12204b1aab70c0eba8222469e064f2cef07fba"", ""source_version"": ""UniProt release 2026_03; entry version 31, sequence version 1"", ""title"": ""UniProtKB unreviewed (TrEMBL) A0A0E3ELC2"", ""url"": ""https://rest.uniprot.org/uniprotkb/A0A0E3ELC2.json""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-070_80363813744d	RHEA:75352	RO:0002233	UniProtKB:A0A0E3ELC2	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.2210/pdb7TLX/pdb|NCBIProtein:WP_080563818.1|PMID:35835223|UniProtKB:A0A0E3ELC2	Concrete S16 protein realization of the generic cytochrome carrier in the chemical equation. This nonstoichiometric role edge adds no further molecule; no stable NicA2-CycN complex or downstream CycN oxidant is asserted.	"[{""reference_id"": ""PMID:35835223"", ""source_assertion"": ""S16 CycN is the experimentally supported physiological electron-accepting protein for this activity."", ""source_locator"": ""PMC9396064 Results p0045-p0060; Fig.5-7; Discussion p0110""}, {""reference_id"": ""UniProtKB:A0A0E3ELC2"", ""source_assertion"": ""The unreviewed entry has 132 amino acids and explicitly links WP_080563818.1 and PDB7TLX (residues28-132). Its merged taxon is303."", ""source_locator"": ""/sequence; /uniProtKBCrossReferences[database=RefSeq,id=WP_080563818.1]; /uniProtKBCrossReferences[database=PDB,id=7TLX]""}, {""reference_id"": ""DOI:10.2210/pdb7TLX/pdb"", ""source_assertion"": ""Entity1 is sourced from S16 (taxon1042876); its105-aa mature sequence and explicit SIFTS alignment match UniProt A0A0E3ELC2 residues28-132."", ""source_locator"": ""/entity_src_gen; /entity_poly/pdbx_seq_one_letter_code_can; /rcsb_polymer_entity_align""}, {""reference_id"": ""NCBIProtein:WP_080563818.1"", ""source_assertion"": ""The full132-aa RefSeq sequence is identical to A0A0E3ELC2 in the reproducible sequence comparison."", ""source_locator"": ""FASTA header WP_080563818.1; complete amino-acid sequence""}]"	"[{""id"": ""DOI:10.2210/pdb7TLX/pdb"", ""source_sha256"": ""df9fbc375a0032b3a2ca9fe86aedab26b0701cf51a68ebc2af714599bcc659b5"", ""source_version"": ""RCSB native author-deposited polymer-entity JSON; retrieved2026-10-11"", ""title"": ""PDB7TLX polymer entity1: S16 mature CycN sequence and source organism"", ""url"": ""https://data.rcsb.org/rest/v1/core/polymer_entity/7TLX/1""}, {""id"": ""NCBIProtein:WP_080563818.1"", ""source_sha256"": ""5a0a775fd06527e8870699bfb5a4517613c4c09533a274c07738f30e1088737f"", ""source_version"": ""Native FASTA retrieved2026-10-11; MULTISPECIES Pseudomonas designation"", ""title"": ""NCBI RefSeq WP_080563818.1 cytochrome c protein sequence"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=WP_080563818.1&rettype=fasta&retmode=text""}, {""id"": ""PMID:35835223"", ""source_sha256"": ""d7c879b84237ffc553ad714d4a2d746bba878bb74f2d5476035d503d27281a89"", ""source_version"": ""Complete primary JATS XML; relevant Results, Methods, figures and source accessions inspected"", ""title"": ""The enzyme pseudooxynicotine amine oxidase from Pseudomonas putida S16 is not an oxidase, but a dehydrogenase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9396064/fullTextXML""}, {""id"": ""UniProtKB:A0A0E3ELC2"", ""source_sha256"": ""c283c70c8900d3f544dc096a4a12204b1aab70c0eba8222469e064f2cef07fba"", ""source_version"": ""UniProt release 2026_03; entry version 31, sequence version 1"", ""title"": ""UniProtKB unreviewed (TrEMBL) A0A0E3ELC2"", ""url"": ""https://rest.uniprot.org/uniprotkb/A0A0E3ELC2.json""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-071_88da88c0c434	RHEA:73656	BFO:0000050	MetaCyc:PWY-6993	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6993|RHEA:73656	Native carbon transformation retained; physiological cytochrome-dependent stoichiometry follows the later primary study and current Rhea/UniProt, replacing the older unspecified-acceptor or oxygen/H2O2 representation.	"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The complete native pathway includes RXN-13076, represented here by RHEA:73656."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-list/Reaction[@frameid='RXN-13076']; reaction-layout[Reaction/@frameid='RXN-13076']""}, {""reference_id"": ""RHEA:73656"", ""source_assertion"": ""Rhea master 73655 explicitly has directed member 73656; the forward chemical equation and sides define this selected reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/73655']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/73656']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/73656']/rh:equation; rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""RHEA:73656"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 73656"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-072_9361f5fbb55d	RHEA:75416	BFO:0000050	MetaCyc:PWY-6993	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6993|PMID:33432238|RHEA:75416	Spontaneous hydration; no catalyst or molecular-activity category is asserted.	"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The complete native pathway includes RXN-13077, represented here by RHEA:75416."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-list/Reaction[@frameid='RXN-13077']; reaction-layout[Reaction/@frameid='RXN-13077']""}, {""reference_id"": ""RHEA:75416"", ""source_assertion"": ""Rhea master 75415 explicitly has directed member 75416; the forward chemical equation and sides define this selected reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/75415']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/75416']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/75416']/rh:equation; rh:substrates; rh:products""}, {""reference_id"": ""PMID:33432238"", ""source_assertion"": ""N-methylmyosmine undergoes spontaneous hydrolysis to pseudooxynicotine."", ""source_locator"": ""PMC7904663 Introduction P5""}]"	"[{""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""PMID:33432238"", ""source_sha256"": ""a2aed7a7d4d5202ecad0908dd77a87f73adc9edfce80547504cdc61e87d4ee2b"", ""source_version"": ""Complete primary JATS XML; relevant Results, Methods, figures and source accessions inspected"", ""title"": ""A cytochrome c is the natural electron acceptor for nicotine oxidoreductase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7904663/fullTextXML""}, {""id"": ""RHEA:75416"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 75416"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-073_ecf785b98321	RHEA:75352	BFO:0000050	MetaCyc:PWY-6993	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6993|RHEA:75352	Native carbon transformation retained; physiological cytochrome-dependent stoichiometry follows the later primary study and current Rhea/UniProt, replacing the older unspecified-acceptor or oxygen/H2O2 representation.	"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The complete native pathway includes RXN-13088, represented here by RHEA:75352."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-list/Reaction[@frameid='RXN-13088']; reaction-layout[Reaction/@frameid='RXN-13088']""}, {""reference_id"": ""RHEA:75352"", ""source_assertion"": ""Rhea master 75351 explicitly has directed member 75352; the forward chemical equation and sides define this selected reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/75351']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/75352']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/75352']/rh:equation; rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""RHEA:75352"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 75352"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-074_29260efc0d95	RHEA:34216	BFO:0000050	MetaCyc:PWY-6993	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8441|MetaCyc:PWY-6993|PMID:24204321|RHEA:34216	Full native NADP-dependent aldehyde oxidation retained. S16 Sapd expression/deletion data support a role, but direct NADP specificity was characterized for HZN6 Sap. No HZN6 tetramer or guessed S16 accession is imported.	"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The complete native pathway includes RXN-13089, represented here by RHEA:34216."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-list/Reaction[@frameid='RXN-13089']; reaction-layout[Reaction/@frameid='RXN-13089']""}, {""reference_id"": ""RHEA:34216"", ""source_assertion"": ""Rhea master 34215 explicitly has directed member 34216; the forward chemical equation and sides define this selected reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34215']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/34216']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34216']/rh:equation; rh:substrates; rh:products""}, {""reference_id"": ""MetaCyc:CPLX-8441"", ""source_assertion"": ""The purified NADP-specific aldehyde dehydrogenase is from HZN6, where it forms a tetramer; this is not an S16 assembly assignment."", ""source_locator"": ""Protein/species; component; comment""}, {""reference_id"": ""PMID:24204321"", ""source_assertion"": ""S16 Sapd PPS_4079 is induced during nicotine growth; its deletion slows growth but does not prevent growth on nicotine."", ""source_locator"": ""PMC3812094 Results s2a proteomics; s2e Functional analysis of mfs and sapd; Fig.3 and Supplementary Fig.4""}]"	"[{""id"": ""MetaCyc:CPLX-8441"", ""source_sha256"": ""ee82760fc2e1580fc17923506586fc3d5b18f35a4a929e8ed066ba9d4c4e6146"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc CPLX-8441: 3-succinoylsemialdehyde-pyridine dehydrogenase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8441""}, {""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""PMID:24204321"", ""source_sha256"": ""8e34eaa3e528e674a94ea47b9ef1cff68ce73b97e4a806d8544b13442734bfe0"", ""source_version"": ""Complete primary JATS XML; relevant Results, Methods, figures and source accessions inspected"", ""title"": ""Systematic Unraveling of the Unsolved Pathway of Nicotine Degradation in Pseudomonas\n"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3812094/fullTextXML""}, {""id"": ""RHEA:34216"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 34216"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-075_dbf9bb6a01e3	MetaCyc:RXN-13082	BFO:0000050	MetaCyc:PWY-6993	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6993		"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The complete native pathway includes RXN-13082, represented here by MetaCyc:RXN-13082."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-list/Reaction[@frameid='RXN-13082']; reaction-layout[Reaction/@frameid='RXN-13082']""}]"	"[{""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-076_16ab65bdb176	RHEA:33928	BFO:0000050	MetaCyc:PWY-6993	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6993|RHEA:33928		"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The complete native pathway includes RXN-13081, represented here by RHEA:33928."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-list/Reaction[@frameid='RXN-13081']; reaction-layout[Reaction/@frameid='RXN-13081']""}, {""reference_id"": ""RHEA:33928"", ""source_assertion"": ""Rhea master 33927 explicitly has directed member 33928; the forward chemical equation and sides define this selected reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33927']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/33928']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/33928']/rh:equation; rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""RHEA:33928"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 33928"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-077_40b97f50f3ff	RHEA:27523	BFO:0000050	MetaCyc:PWY-6993	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6993|RHEA:27523		"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The complete native pathway includes 1.13.11.9-RXN, represented here by RHEA:27523."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-list/Reaction[@frameid='1.13.11.9-RXN']; reaction-layout[Reaction/@frameid='1.13.11.9-RXN']""}, {""reference_id"": ""RHEA:27523"", ""source_assertion"": ""Rhea master 27522 explicitly has directed member 27523; the forward chemical equation and sides define this selected reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27522']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/27523']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27523']/rh:equation; rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""RHEA:27523"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 27523"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-078_d88d7739676e	RHEA:30844	BFO:0000050	MetaCyc:PWY-6993	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6993|RHEA:30844		"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The complete native pathway includes RXN-11318, represented here by RHEA:30844."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-list/Reaction[@frameid='RXN-11318']; reaction-layout[Reaction/@frameid='RXN-11318']""}, {""reference_id"": ""RHEA:30844"", ""source_assertion"": ""Rhea master 30843 explicitly has directed member 30844; the forward chemical equation and sides define this selected reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30843']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/30844']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/30844']/rh:equation; rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""RHEA:30844"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 30844"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-079_76e6b09a7a8f	RHEA:27386	BFO:0000050	MetaCyc:PWY-6993	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6993|RHEA:27386		"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The complete native pathway includes RXN-646, represented here by RHEA:27386."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-list/Reaction[@frameid='RXN-646']; reaction-layout[Reaction/@frameid='RXN-646']""}, {""reference_id"": ""RHEA:27386"", ""source_assertion"": ""Rhea master 27385 explicitly has directed member 27386; the forward chemical equation and sides define this selected reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27385']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/27386']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27386']/rh:equation; rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""RHEA:27386"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 27386"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-080_d69dee6e7eec	RHEA:13170	BFO:0000050	MetaCyc:PWY-6993	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6993|RHEA:13170		"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The complete native pathway includes MALEATE-ISOMERASE-RXN, represented here by RHEA:13170."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-list/Reaction[@frameid='MALEATE-ISOMERASE-RXN']; reaction-layout[Reaction/@frameid='MALEATE-ISOMERASE-RXN']""}, {""reference_id"": ""RHEA:13170"", ""source_assertion"": ""Rhea master 13169 explicitly has directed member 13170; the forward chemical equation and sides define this selected reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13169']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/13170']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13170']/rh:equation; rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""RHEA:13170"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 13170"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-081_202bcc48fc77	RHEA:13214	BFO:0000050	MetaCyc:PWY-6993	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6993|RHEA:13214	The native pathway includes this NADP-dependent succinate-semialdehyde branch. Inspected native enzyme frames are from other organisms; an exact S16 catalyst and direct S16 cofactor-specific assay remain unresolved.	"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The complete native pathway includes SUCCSEMIALDDEHYDROG-RXN, represented here by RHEA:13214."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-list/Reaction[@frameid='SUCCSEMIALDDEHYDROG-RXN']; reaction-layout[Reaction/@frameid='SUCCSEMIALDDEHYDROG-RXN']""}, {""reference_id"": ""RHEA:13214"", ""source_assertion"": ""Rhea master 13213 explicitly has directed member 13214; the forward chemical equation and sides define this selected reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13213']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/13214']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13214']/rh:equation; rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""RHEA:13214"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 13214"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-082_46311328e2ee	RHEA:73656	RO:0002413	RHEA:75416	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:190393|MetaCyc:PWY-6993|RHEA:73656|RHEA:75416	Direct carbon-intermediate transfer via CHEBI:190393. Carrier recycling and shared water/cofactor pools do not generate additional pathway-order edges.	"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The native pathway orders RXN-13076 before RXN-13077 and supplies the corresponding native compound layout; current chemical identity is supported separately by the reaction-side evidence."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-ordering[Reaction/@frameid='RXN-13077']/predecessor-reactions/Reaction[@frameid='RXN-13076']; reaction-layout""}, {""reference_id"": ""RHEA:73656"", ""source_assertion"": ""RHEA:73656 products contain CHEBI:193521 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/73656']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/73655_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_73655_compound_18516']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_73655_compound_18516']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_18516']/rh:accession""}, {""reference_id"": ""CHEBI:190393"", ""source_assertion"": ""ChEBI193521 is deprecated and explicitly replaced by CHEBI190393;190393 retains193521 as an alternative ID and has the same C10H13N2 formula and +1 charge."", ""source_locator"": ""statements[subject=CHEBI:193521,predicate=IAO:0100001,object=CHEBI:190393]; statements[subject=CHEBI:190393,predicate=oio:hasAlternativeId,value=CHEBI:193521]; chemrof formula/charge""}, {""reference_id"": ""RHEA:75416"", ""source_assertion"": ""RHEA:75416 substrates contain CHEBI:193521 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/75416']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/75415_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_75415_compound_18516']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_75415_compound_18516']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_18516']/rh:accession""}, {""reference_id"": ""CHEBI:190393"", ""source_assertion"": ""ChEBI193521 is deprecated and explicitly replaced by CHEBI190393;190393 retains193521 as an alternative ID and has the same C10H13N2 formula and +1 charge."", ""source_locator"": ""statements[subject=CHEBI:193521,predicate=IAO:0100001,object=CHEBI:190393]; statements[subject=CHEBI:190393,predicate=oio:hasAlternativeId,value=CHEBI:193521]; chemrof formula/charge""}]"	"[{""id"": ""CHEBI:190393"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI255; digest identifies uncompressed Semantic SQL database, not OWL source bytes"", ""title"": ""ChEBI255 explicit N-methylmyosmine replacement"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""RHEA:73656"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 73656"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:75416"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 75416"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-083_fc14af0e6164	RHEA:75416	RO:0002413	RHEA:75352	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6993|RHEA:75352|RHEA:75416	Direct carbon-intermediate transfer via CHEBI:66878. Carrier recycling and shared water/cofactor pools do not generate additional pathway-order edges.	"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The native pathway orders RXN-13077 before RXN-13088 and supplies the corresponding native compound layout; current chemical identity is supported separately by the reaction-side evidence."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-ordering[Reaction/@frameid='RXN-13088']/predecessor-reactions/Reaction[@frameid='RXN-13077']; reaction-layout""}, {""reference_id"": ""RHEA:75416"", ""source_assertion"": ""RHEA:75416 products contain CHEBI:66878 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/75416']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/75415_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_75415_compound_7380']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_75415_compound_7380']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_7380']/rh:accession""}, {""reference_id"": ""RHEA:75352"", ""source_assertion"": ""RHEA:75352 substrates contain CHEBI:66878 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/75352']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/75351_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_75351_compound_7380']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_75351_compound_7380']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_7380']/rh:accession""}]"	"[{""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""RHEA:75352"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 75352"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:75416"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 75416"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-084_52243f952cf9	RHEA:75352	RO:0002413	RHEA:34216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6993|RHEA:34216|RHEA:75352	Direct carbon-intermediate transfer via CHEBI:66879. Carrier recycling and shared water/cofactor pools do not generate additional pathway-order edges.	"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The native pathway orders RXN-13088 before RXN-13089 and supplies the corresponding native compound layout; current chemical identity is supported separately by the reaction-side evidence."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-ordering[Reaction/@frameid='RXN-13089']/predecessor-reactions/Reaction[@frameid='RXN-13088']; reaction-layout""}, {""reference_id"": ""RHEA:75352"", ""source_assertion"": ""RHEA:75352 products contain CHEBI:66879 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/75352']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/75351_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_75351_compound_7379']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_75351_compound_7379']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_7379']/rh:accession""}, {""reference_id"": ""RHEA:34216"", ""source_assertion"": ""RHEA:34216 substrates contain CHEBI:66879 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34216']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34215_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_34215_compound_7379']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_34215_compound_7379']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_7379']/rh:accession""}]"	"[{""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""RHEA:34216"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 34216"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:75352"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 75352"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-085_8fdc4073eaa6	RHEA:34216	RO:0002413	MetaCyc:RXN-13082	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-14094|MetaCyc:PWY-6993|MetaCyc:RXN-13082|RHEA:34216	Direct carbon-intermediate transfer via CHEBI:66942. Carrier recycling and shared water/cofactor pools do not generate additional pathway-order edges.	"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The native pathway orders RXN-13089 before RXN-13082 and supplies the corresponding native compound layout; current chemical identity is supported separately by the reaction-side evidence."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-ordering[Reaction/@frameid='RXN-13082']/predecessor-reactions/Reaction[@frameid='RXN-13089']; reaction-layout""}, {""reference_id"": ""RHEA:34216"", ""source_assertion"": ""RHEA:34216 products contain CHEBI:66942 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/34216']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/34215_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_34215_compound_7458']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_34215_compound_7458']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_7458']/rh:accession""}, {""reference_id"": ""MetaCyc:RXN-13082"", ""source_assertion"": ""Native left participant CPD-14094 has coefficient 1 in Spm hydroxylation."", ""source_locator"": ""Reaction[@frameid='RXN-13082']/left/Compound[@frameid='CPD-14094']; ../coefficient (omitted coefficient denotes one)""}, {""reference_id"": ""MetaCyc:CPD-14094"", ""source_assertion"": ""The native compound cross-reference is CHEBI:66942; its displayed role is retained without assigning a physiological Spm electron-acceptor species."", ""source_locator"": ""Compound[@frameid='CPD-14094']/dblink[dblink-db='CHEBI']/dblink-oid; common-name""}]"	"[{""id"": ""MetaCyc:CPD-14094"", ""source_sha256"": ""7893f5aa16242a96d198c0f98430dc976de2c6bb793e6e19794e500441fe13c7"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc CPD-14094: 4-oxo-4-(3-pyridyl)-butanoate"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-14094""}, {""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""MetaCyc:RXN-13082"", ""source_sha256"": ""135163b28080c248a0a5727db85b3926ea63fcb51d7ee6e563aa73e7d2340597"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc RXN-13082: RXN-13082"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-13082""}, {""id"": ""RHEA:34216"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 34216"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-086_d72a56da018e	MetaCyc:RXN-13082	RO:0002413	RHEA:33928	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPD-14096|MetaCyc:PWY-6993|MetaCyc:RXN-13082|RHEA:33928	Direct carbon-intermediate transfer via CHEBI:66893. Carrier recycling and shared water/cofactor pools do not generate additional pathway-order edges.	"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The native pathway orders RXN-13082 before RXN-13081 and supplies the corresponding native compound layout; current chemical identity is supported separately by the reaction-side evidence."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-ordering[Reaction/@frameid='RXN-13081']/predecessor-reactions/Reaction[@frameid='RXN-13082']; reaction-layout""}, {""reference_id"": ""MetaCyc:RXN-13082"", ""source_assertion"": ""Native right participant CPD-14096 has coefficient 1 in Spm hydroxylation."", ""source_locator"": ""Reaction[@frameid='RXN-13082']/right/Compound[@frameid='CPD-14096']; ../coefficient (omitted coefficient denotes one)""}, {""reference_id"": ""MetaCyc:CPD-14096"", ""source_assertion"": ""The native compound cross-reference is CHEBI:66893; its displayed role is retained without assigning a physiological Spm electron-acceptor species."", ""source_locator"": ""Compound[@frameid='CPD-14096']/dblink[dblink-db='CHEBI']/dblink-oid; common-name""}, {""reference_id"": ""RHEA:33928"", ""source_assertion"": ""RHEA:33928 substrates contain CHEBI:66893 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33928']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/33927_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_33927_compound_7386']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_33927_compound_7386']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_7386']/rh:accession""}]"	"[{""id"": ""MetaCyc:CPD-14096"", ""source_sha256"": ""d3bc1645f7f10f06955c3bfb63ccf2da3266f36aab19f3cbc7dbe59aebc1b704"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc CPD-14096: 6-hydroxy-3-succinoyl-pyridine"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-14096""}, {""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""MetaCyc:RXN-13082"", ""source_sha256"": ""135163b28080c248a0a5727db85b3926ea63fcb51d7ee6e563aa73e7d2340597"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc RXN-13082: RXN-13082"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-13082""}, {""id"": ""RHEA:33928"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 33928"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-087_db5006764558	RHEA:33928	RO:0002413	RHEA:27523	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6993|RHEA:27523|RHEA:33928	Direct carbon-intermediate transfer via CHEBI:16364. Carrier recycling and shared water/cofactor pools do not generate additional pathway-order edges.	"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The native pathway orders RXN-13081 before 1.13.11.9-RXN and supplies the corresponding native compound layout; current chemical identity is supported separately by the reaction-side evidence."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-ordering[Reaction/@frameid='1.13.11.9-RXN']/predecessor-reactions/Reaction[@frameid='RXN-13081']; reaction-layout""}, {""reference_id"": ""RHEA:33928"", ""source_assertion"": ""RHEA:33928 products contain CHEBI:16364 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33928']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/33927_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_33927_compound_3377']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_33927_compound_3377']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3377']/rh:accession""}, {""reference_id"": ""RHEA:27523"", ""source_assertion"": ""RHEA:27523 substrates contain CHEBI:16364 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27523']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27522_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27522_compound_3377']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_27522_compound_3377']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3377']/rh:accession""}]"	"[{""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""RHEA:27523"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 27523"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:33928"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 33928"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-088_76cd83fe2e5b	RHEA:27523	RO:0002413	RHEA:30844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6993|RHEA:27523|RHEA:30844	Direct carbon-intermediate transfer via CHEBI:59911. Carrier recycling and shared water/cofactor pools do not generate additional pathway-order edges.	"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The native pathway orders 1.13.11.9-RXN before RXN-11318 and supplies the corresponding native compound layout; current chemical identity is supported separately by the reaction-side evidence."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-ordering[Reaction/@frameid='RXN-11318']/predecessor-reactions/Reaction[@frameid='1.13.11.9-RXN']; reaction-layout""}, {""reference_id"": ""RHEA:27523"", ""source_assertion"": ""RHEA:27523 products contain CHEBI:59911 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27523']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27522_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27522_compound_6228']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_27522_compound_6228']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_6228']/rh:accession""}, {""reference_id"": ""RHEA:30844"", ""source_assertion"": ""RHEA:30844 substrates contain CHEBI:59911 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30844']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/30843_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_30843_compound_6228']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_30843_compound_6228']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_6228']/rh:accession""}]"	"[{""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""RHEA:27523"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 27523"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:30844"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 30844"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-089_e3fb0b3c685e	RHEA:30844	RO:0002413	RHEA:27386	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6993|RHEA:27386|RHEA:30844	Direct carbon-intermediate transfer via CHEBI:16146. Carrier recycling and shared water/cofactor pools do not generate additional pathway-order edges.	"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The native pathway orders RXN-11318 before RXN-646 and supplies the corresponding native compound layout; current chemical identity is supported separately by the reaction-side evidence."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-ordering[Reaction/@frameid='RXN-646']/predecessor-reactions/Reaction[@frameid='RXN-11318']; reaction-layout""}, {""reference_id"": ""RHEA:30844"", ""source_assertion"": ""RHEA:30844 products contain CHEBI:16146 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30844']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/30843_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_30843_compound_3670']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_30843_compound_3670']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3670']/rh:accession""}, {""reference_id"": ""RHEA:27386"", ""source_assertion"": ""RHEA:27386 substrates contain CHEBI:16146 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27386']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27385_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27385_compound_3670']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_27385_compound_3670']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_3670']/rh:accession""}]"	"[{""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""RHEA:27386"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 27386"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:30844"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 30844"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-090_3cb2de961195	RHEA:27386	RO:0002413	RHEA:13170	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6993|RHEA:13170|RHEA:27386	Direct carbon-intermediate transfer via CHEBI:30780. Carrier recycling and shared water/cofactor pools do not generate additional pathway-order edges.	"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The native pathway orders RXN-646 before MALEATE-ISOMERASE-RXN and supplies the corresponding native compound layout; current chemical identity is supported separately by the reaction-side evidence."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-ordering[Reaction/@frameid='MALEATE-ISOMERASE-RXN']/predecessor-reactions/Reaction[@frameid='RXN-646']; reaction-layout""}, {""reference_id"": ""RHEA:27386"", ""source_assertion"": ""RHEA:27386 products contain CHEBI:30780 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27386']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27385_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27385_compound_2303']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_27385_compound_2303']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_2303']/rh:accession""}, {""reference_id"": ""RHEA:13170"", ""source_assertion"": ""RHEA:13170 substrates contain CHEBI:30780 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13170']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13169_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13169_compound_2303']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_13169_compound_2303']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_2303']/rh:accession""}]"	"[{""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""RHEA:13170"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 13170"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:27386"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 27386"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-091_69c4f09587ce	RHEA:33928	RO:0002413	RHEA:13214	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6993|RHEA:13214|RHEA:33928	Direct carbon-intermediate transfer via CHEBI:57706. Carrier recycling and shared water/cofactor pools do not generate additional pathway-order edges.	"[{""reference_id"": ""MetaCyc:PWY-6993"", ""source_assertion"": ""The native pathway orders RXN-13081 before SUCCSEMIALDDEHYDROG-RXN and supplies the corresponding native compound layout; current chemical identity is supported separately by the reaction-side evidence."", ""source_locator"": ""Pathway[@frameid='PWY-6993']/reaction-ordering[Reaction/@frameid='SUCCSEMIALDDEHYDROG-RXN']/predecessor-reactions/Reaction[@frameid='RXN-13081']; reaction-layout""}, {""reference_id"": ""RHEA:33928"", ""source_assertion"": ""RHEA:33928 products contain CHEBI:57706 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33928']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/33927_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_33927_compound_4279']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_33927_compound_4279']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_4279']/rh:accession""}, {""reference_id"": ""RHEA:13214"", ""source_assertion"": ""RHEA:13214 substrates contain CHEBI:57706 with coefficient 1. Whole cytochrome states are retained when the participant is generic protein."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13214']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13213_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13213_compound_4279']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Participant_13213_compound_4279']/rh:compound; rdf:Description[@rdf:about='http://rdf.rhea-db.org/Compound_4279']/rh:accession""}]"	"[{""id"": ""MetaCyc:PWY-6993"", ""source_sha256"": ""f3fdd212ea8a22f80d23fd62fb2f47b54b367445deeeffd8954fdf121ea860e8"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-6993: nicotine degradation II (pyrrolidine pathway)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6993""}, {""id"": ""RHEA:13214"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 13214"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:33928"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete RDF with exact family and reaction-side projection"", ""title"": ""Rhea directed reaction 33928"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-092_b8f573eb5b85	UniProtKB:F8G0P2	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:F8G0P2	FAD prosthetic cofactor; does not add free FAD/FADH2 turnover to the pathway equation. HspB FAD assignment retains ECO:0000305; NicA2 and Pnao retain their experimental annotations.	"[{""reference_id"": ""UniProtKB:F8G0P2"", ""source_assertion"": ""The current protein entry annotates FAD binding with source-specific experimental or curator-inferred evidence; FAD remains protein bound."", ""source_locator"": ""/comments[commentType=COFACTOR]/cofactors; note""}]"	"[{""id"": ""UniProtKB:F8G0P2"", ""source_sha256"": ""ebf487ac3b45c9804f5e74b7574b9efa4a98477c6f9fda1743b6b9185e8b449b"", ""source_version"": ""UniProt release 2026_03; entry version 57, sequence version 1"", ""title"": ""UniProtKB reviewed (Swiss-Prot) F8G0P2"", ""url"": ""https://rest.uniprot.org/uniprotkb/F8G0P2.json""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-093_7d7e6a68e25c	UniProtKB:F8G0P1	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:F8G0P1	FAD prosthetic cofactor; does not add free FAD/FADH2 turnover to the pathway equation. HspB FAD assignment retains ECO:0000305; NicA2 and Pnao retain their experimental annotations.	"[{""reference_id"": ""UniProtKB:F8G0P1"", ""source_assertion"": ""The current protein entry annotates FAD binding with source-specific experimental or curator-inferred evidence; FAD remains protein bound."", ""source_locator"": ""/comments[commentType=COFACTOR]/cofactors; note""}]"	"[{""id"": ""UniProtKB:F8G0P1"", ""source_sha256"": ""d6785536436f1b1889450c91375c7430f02340db443aa1252f9711b334f20590"", ""source_version"": ""UniProt release 2026_03; entry version 49, sequence version 1"", ""title"": ""UniProtKB reviewed (Swiss-Prot) F8G0P1"", ""url"": ""https://rest.uniprot.org/uniprotkb/F8G0P1.json""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-094_9857715dd531	UniProtKB:F8G0M4	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:F8G0M4	FAD prosthetic cofactor; does not add free FAD/FADH2 turnover to the pathway equation. HspB FAD assignment retains ECO:0000305; NicA2 and Pnao retain their experimental annotations.	"[{""reference_id"": ""UniProtKB:F8G0M4"", ""source_assertion"": ""The current protein entry annotates FAD binding with source-specific experimental or curator-inferred evidence; FAD remains protein bound."", ""source_locator"": ""/comments[commentType=COFACTOR]/cofactors; note""}]"	"[{""id"": ""UniProtKB:F8G0M4"", ""source_sha256"": ""84ceb1632d706ffdddae9428be5d8c694666342d9c0ece6ee901c206916d373c"", ""source_version"": ""UniProt release 2026_03; entry version 54, sequence version 1"", ""title"": ""UniProtKB reviewed (Swiss-Prot) F8G0M4"", ""url"": ""https://rest.uniprot.org/uniprotkb/F8G0M4.json""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-095_c2a3cc04b08b	UniProtKB:F8G0M1	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:22530095	Ferrous-iron activity requirement from the primary assay; physiological metal occupancy and a structural binding site were not measured here.	"[{""reference_id"": ""PMID:22530095"", ""source_assertion"": ""Ferrous iron markedly increased Hpo activity among the tested metals; the assay contained 0.025 mM Fe2+."", ""source_locator"": ""PMC3332521 Results Hpo; Fig.2D; Methods Determination of Hpo activity; body paragraphs5,17,24""}]"	"[{""id"": ""PMID:22530095"", ""source_sha256"": ""3992e04ad2ee4a89a774dde2b148343b4de0fd8cf7fd82fa96541c71dcdb88ff"", ""source_version"": ""Complete primary JATS XML; relevant Results, Methods, figures and source accessions inspected"", ""title"": ""Genomic analysis of Pseudomonas putida: genes in a genome island are crucial for nicotine degradation"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3332521/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-096_d75ace20f0f6	MetaCyc:CPLX-8991	pathwaymech:has_cofactor	MetaCyc:CPD0-1882	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-23743|PMID:24204321	Proposed Mo-MCD association, not a purified cofactor determination. The native chemical identity is preserved because its formula/charge differs from its current ChEBI cross-reference; no oxidation-state equivalence is asserted.	"[{""reference_id"": ""MetaCyc:ENZRXN-23743"", ""source_assertion"": ""The native source assigns cytidylyl molybdenum cofactor to the SpmABC enzymatic reaction."", ""source_locator"": ""Enzymatic-Reaction/cofactor/Compound[@frameid=CPD0-1882]""}, {""reference_id"": ""PMID:24204321"", ""source_assertion"": ""The authors propose a Mo-MCD-containing Spm hydroxylase from family similarity and failed active expression in E. coli."", ""source_locator"": ""PMC3812094 Discussion, paragraph beginning In the last few years""}]"	"[{""id"": ""MetaCyc:ENZRXN-23743"", ""source_sha256"": ""af817cdd8f9dc880bbcd18e671fefb2f0f148df2ba80d91aeff799d01e3c20ca"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""MetaCyc ENZRXN-23743: 3-succinoylpyridine monooxygenase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-23743""}, {""id"": ""PMID:24204321"", ""source_sha256"": ""8e34eaa3e528e674a94ea47b9ef1cff68ce73b97e4a806d8544b13442734bfe0"", ""source_version"": ""Complete primary JATS XML; relevant Results, Methods, figures and source accessions inspected"", ""title"": ""Systematic Unraveling of the Unsolved Pathway of Nicotine Degradation in Pseudomonas\n"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3812094/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-097_6128024acee6	UniProtKB:F8G0P2	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:35835223	Predicted native localization, not direct S16 fractionation or exclusive localization. Recombinant periplasmic expression of CycN does not by itself establish native localization.	"[{""reference_id"": ""PMID:35835223"", ""source_assertion"": ""NicA2, Pnao and CycN are predicted to contain N-terminal signal sequences for periplasmic export."", ""source_locator"": ""PMC9396064 Introduction p0015""}]"	"[{""id"": ""PMID:35835223"", ""source_sha256"": ""d7c879b84237ffc553ad714d4a2d746bba878bb74f2d5476035d503d27281a89"", ""source_version"": ""Complete primary JATS XML; relevant Results, Methods, figures and source accessions inspected"", ""title"": ""The enzyme pseudooxynicotine amine oxidase from Pseudomonas putida S16 is not an oxidase, but a dehydrogenase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9396064/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-098_2edcf62aa0e5	UniProtKB:F8G0P1	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:35835223	Predicted native localization, not direct S16 fractionation or exclusive localization. Recombinant periplasmic expression of CycN does not by itself establish native localization.	"[{""reference_id"": ""PMID:35835223"", ""source_assertion"": ""NicA2, Pnao and CycN are predicted to contain N-terminal signal sequences for periplasmic export."", ""source_locator"": ""PMC9396064 Introduction p0015""}]"	"[{""id"": ""PMID:35835223"", ""source_sha256"": ""d7c879b84237ffc553ad714d4a2d746bba878bb74f2d5476035d503d27281a89"", ""source_version"": ""Complete primary JATS XML; relevant Results, Methods, figures and source accessions inspected"", ""title"": ""The enzyme pseudooxynicotine amine oxidase from Pseudomonas putida S16 is not an oxidase, but a dehydrogenase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9396064/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-6993_nic-edge-099_f87473fe2ff2	UniProtKB:A0A0E3ELC2	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:35835223	Predicted native localization, not direct S16 fractionation or exclusive localization. Recombinant periplasmic expression of CycN does not by itself establish native localization.	"[{""reference_id"": ""PMID:35835223"", ""source_assertion"": ""NicA2, Pnao and CycN are predicted to contain N-terminal signal sequences for periplasmic export."", ""source_locator"": ""PMC9396064 Introduction p0015""}]"	"[{""id"": ""PMID:35835223"", ""source_sha256"": ""d7c879b84237ffc553ad714d4a2d746bba878bb74f2d5476035d503d27281a89"", ""source_version"": ""Complete primary JATS XML; relevant Results, Methods, figures and source accessions inspected"", ""title"": ""The enzyme pseudooxynicotine amine oxidase from Pseudomonas putida S16 is not an oxidase, but a dehydrogenase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9396064/fullTextXML""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-001_2580e1ce5e96	MetaCyc:DENITRIFICATION-PWY	BFO:0000051	MetaCyc:RXN-11236	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DENITRIFICATION-PWY	Complete native route member; source reaction direction is retained separately from the pathway L2R traversal.	"[{""reference_id"": ""MetaCyc:DENITRIFICATION-PWY"", ""source_assertion"": ""The pathway explicitly lists RXN-11236 and assigns L2R traversal."", ""source_locator"": ""XPath /ptools-xml/Pathway/reaction-list/Reaction[@frameid=\""RXN-11236\""]; /ptools-xml/Pathway/reaction-layout[Reaction/@frameid=\""RXN-11236\""]/direction""}]"	"[{""id"": ""MetaCyc:DENITRIFICATION-PWY"", ""source_sha256"": ""9a11dcba9fba820b150fa11cea42a9d1163739fdab59274bbe634714b612785a"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrate reduction I (denitrification)"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:DENITRIFICATION-PWY""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-002_4fa84aa21c08	MetaCyc:DENITRIFICATION-PWY	BFO:0000051	MetaCyc:TRANS-RXN0-239	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DENITRIFICATION-PWY|PMID:16391109	Native nitrate/nitrite antiport convention is retained as a complete source-defined step. PAO1 transport function is experimentally supported, but strict antiport versus uniport and its exact catalyst assignment remain unresolved.	"[{""reference_id"": ""MetaCyc:DENITRIFICATION-PWY"", ""source_assertion"": ""The pathway explicitly lists TRANS-RXN0-239 and assigns L2R traversal."", ""source_locator"": ""XPath /ptools-xml/Pathway/reaction-list/Reaction[@frameid=\""TRANS-RXN0-239\""]; /ptools-xml/Pathway/reaction-layout[Reaction/@frameid=\""TRANS-RXN0-239\""]/direction""}, {""reference_id"": ""PMID:16391109"", ""source_assertion"": ""The authors explicitly state that antiport versus uniport remains to be conclusively experimentally proven."", ""source_locator"": ""XPath //article/section[2]/section/section[4]/p[5]""}]"	"[{""id"": ""MetaCyc:DENITRIFICATION-PWY"", ""source_sha256"": ""9a11dcba9fba820b150fa11cea42a9d1163739fdab59274bbe634714b612785a"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrate reduction I (denitrification)"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:DENITRIFICATION-PWY""}, {""id"": ""PMID:16391109"", ""source_sha256"": ""1faa67e8157884747e253b3aef423e8d6f9038e7e4921e3793e3afc2e25ed132"", ""source_version"": ""Original PMC primary HTML; full article inspected; retrieved 2026-10-11"", ""title"": ""Involvement of NarK1 and NarK2 Proteins in Transport of Nitrate and Nitrite in the Denitrifying Bacterium Pseudomonas aeruginosa PAO1"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1352271/""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-003_64dd00d5c122	MetaCyc:DENITRIFICATION-PWY	BFO:0000051	MetaCyc:RXN-15838	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DENITRIFICATION-PWY	Complete native route member; source reaction direction is retained separately from the pathway L2R traversal.	"[{""reference_id"": ""MetaCyc:DENITRIFICATION-PWY"", ""source_assertion"": ""The pathway explicitly lists RXN-15838 and assigns L2R traversal."", ""source_locator"": ""XPath /ptools-xml/Pathway/reaction-list/Reaction[@frameid=\""RXN-15838\""]; /ptools-xml/Pathway/reaction-layout[Reaction/@frameid=\""RXN-15838\""]/direction""}]"	"[{""id"": ""MetaCyc:DENITRIFICATION-PWY"", ""source_sha256"": ""9a11dcba9fba820b150fa11cea42a9d1163739fdab59274bbe634714b612785a"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrate reduction I (denitrification)"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:DENITRIFICATION-PWY""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-004_2aee370ddf69	MetaCyc:DENITRIFICATION-PWY	BFO:0000051	MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DENITRIFICATION-PWY	Complete native route member; source reaction direction is retained separately from the pathway L2R traversal.	"[{""reference_id"": ""MetaCyc:DENITRIFICATION-PWY"", ""source_assertion"": ""The pathway explicitly lists NITRIC-OXIDE-REDUCTASE-RXN and assigns L2R traversal."", ""source_locator"": ""XPath /ptools-xml/Pathway/reaction-list/Reaction[@frameid=\""NITRIC-OXIDE-REDUCTASE-RXN\""]; /ptools-xml/Pathway/reaction-layout[Reaction/@frameid=\""NITRIC-OXIDE-REDUCTASE-RXN\""]/direction""}]"	"[{""id"": ""MetaCyc:DENITRIFICATION-PWY"", ""source_sha256"": ""9a11dcba9fba820b150fa11cea42a9d1163739fdab59274bbe634714b612785a"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrate reduction I (denitrification)"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:DENITRIFICATION-PWY""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-005_3a9fb0088c88	MetaCyc:DENITRIFICATION-PWY	BFO:0000051	MetaCyc:RXN-12130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DENITRIFICATION-PWY	Complete native route member; source reaction direction is retained separately from the pathway L2R traversal.	"[{""reference_id"": ""MetaCyc:DENITRIFICATION-PWY"", ""source_assertion"": ""The pathway explicitly lists RXN-12130 and assigns L2R traversal."", ""source_locator"": ""XPath /ptools-xml/Pathway/reaction-list/Reaction[@frameid=\""RXN-12130\""]; /ptools-xml/Pathway/reaction-layout[Reaction/@frameid=\""RXN-12130\""]/direction""}]"	"[{""id"": ""MetaCyc:DENITRIFICATION-PWY"", ""source_sha256"": ""9a11dcba9fba820b150fa11cea42a9d1163739fdab59274bbe634714b612785a"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrate reduction I (denitrification)"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:DENITRIFICATION-PWY""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-006_1d1807794e7e	MetaCyc:ETR-Quinols	pathwaymech:consumes	MetaCyc:RXN-11236	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ETR-Quinols|MetaCyc:RXN-11236	Coefficient 1; membrane electron-transfer class; side not specified. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-11236"", ""source_assertion"": ""The left side contains coefficient 1 of ETR-Quinols; no side compartment is specified."", ""source_locator"": ""XPath /ptools-xml/Reaction/left[1]""}, {""reference_id"": ""MetaCyc:ETR-Quinols"", ""source_assertion"": ""The issuing native object identifies this whole class as an electron-transfer quinol; no unique molecular formula or sequence is asserted."", ""source_locator"": ""XPath /ptools-xml/Compound/common-name""}]"	"[{""id"": ""MetaCyc:ETR-Quinols"", ""source_sha256"": ""54a13f0a05daf0662fb763a97f7a8fb2542e09561ee8e310514b4ebb94903007"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""an electron-transfer quinol"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:ETR-Quinols""}, {""id"": ""MetaCyc:RXN-11236"", ""source_sha256"": ""6da8edb0079cd32cee8668e80f6af61602c5c18dddd38e5d812fe3421dbae047"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-11236"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-11236""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-007_329f490f362d	CHEBI:17632	pathwaymech:consumes	MetaCyc:RXN-11236	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:17632|MetaCyc:NITRATE|MetaCyc:RXN-11236	Coefficient 1; cytoplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-11236"", ""source_assertion"": ""The left side contains coefficient 1 of NITRATE in CCO-IN."", ""source_locator"": ""XPath /ptools-xml/Reaction/left[2]""}, {""reference_id"": ""MetaCyc:NITRATE"", ""source_assertion"": ""The native NITRATE object has InChI InChI=1S/NO3/c2-1(3)4/q-1."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:17632"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula NO3, charge -1."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:17632; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:17632"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""nitrate"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:NITRATE"", ""source_sha256"": ""88035a8ef9ce4eb27070cb691f0197ded9e7d58f1deb6c3d6ade5a845247511f"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrate"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NITRATE""}, {""id"": ""MetaCyc:RXN-11236"", ""source_sha256"": ""6da8edb0079cd32cee8668e80f6af61602c5c18dddd38e5d812fe3421dbae047"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-11236"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-11236""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-008_90ad3535e2cf	CHEBI:15378	pathwaymech:consumes	MetaCyc:RXN-11236	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-11236	Coefficient 2; cytoplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-11236"", ""source_assertion"": ""The left side contains coefficient 2 of PROTON in CCO-IN."", ""source_locator"": ""XPath /ptools-xml/Reaction/left[3]""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native PROTON object has InChI InChI=1S/p+1."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula H, charge 1."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:15378; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""hydron"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""22115ac465b8f70fb4d34d11e93120cafb805cbc00c2391f21a5a27f1563602f"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""H+"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PROTON""}, {""id"": ""MetaCyc:RXN-11236"", ""source_sha256"": ""6da8edb0079cd32cee8668e80f6af61602c5c18dddd38e5d812fe3421dbae047"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-11236"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-11236""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-009_903227f2b807	MetaCyc:RXN-11236	pathwaymech:produces	MetaCyc:ETR-Quinones	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ETR-Quinones|MetaCyc:RXN-11236	Coefficient 1; membrane electron-transfer class; side not specified. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-11236"", ""source_assertion"": ""The right side contains coefficient 1 of ETR-Quinones; no side compartment is specified."", ""source_locator"": ""XPath /ptools-xml/Reaction/right[1]""}, {""reference_id"": ""MetaCyc:ETR-Quinones"", ""source_assertion"": ""The issuing native object identifies this whole class as an electron-transfer quinone; no unique molecular formula or sequence is asserted."", ""source_locator"": ""XPath /ptools-xml/Compound/common-name""}]"	"[{""id"": ""MetaCyc:ETR-Quinones"", ""source_sha256"": ""e9469359b1a0213b18304692727e68ba9b9ab459133b357a085b2cecbd8bc7e8"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""an electron-transfer quinone"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:ETR-Quinones""}, {""id"": ""MetaCyc:RXN-11236"", ""source_sha256"": ""6da8edb0079cd32cee8668e80f6af61602c5c18dddd38e5d812fe3421dbae047"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-11236"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-11236""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-010_ddde7c155e5a	MetaCyc:RXN-11236	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-11236	Coefficient 2; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-11236"", ""source_assertion"": ""The right side contains coefficient 2 of PROTON in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/right[2]""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native PROTON object has InChI InChI=1S/p+1."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula H, charge 1."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:15378; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""hydron"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""22115ac465b8f70fb4d34d11e93120cafb805cbc00c2391f21a5a27f1563602f"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""H+"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PROTON""}, {""id"": ""MetaCyc:RXN-11236"", ""source_sha256"": ""6da8edb0079cd32cee8668e80f6af61602c5c18dddd38e5d812fe3421dbae047"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-11236"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-11236""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-011_b09b41ee4447	MetaCyc:RXN-11236	pathwaymech:produces	CHEBI:16301	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:16301|MetaCyc:NITRITE|MetaCyc:RXN-11236	Coefficient 1; cytoplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-11236"", ""source_assertion"": ""The right side contains coefficient 1 of NITRITE in CCO-IN."", ""source_locator"": ""XPath /ptools-xml/Reaction/right[3]""}, {""reference_id"": ""MetaCyc:NITRITE"", ""source_assertion"": ""The native NITRITE object has InChI InChI=1S/HNO2/c2-1-3/h(H,2,3)/p-1."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:16301"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula NO2, charge -1."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:16301; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:16301"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""nitrite"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:NITRITE"", ""source_sha256"": ""ff43e11bd0ed78b0f1464af713b5976fced522f06b91cc176d718a816ae8f119"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrite"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NITRITE""}, {""id"": ""MetaCyc:RXN-11236"", ""source_sha256"": ""6da8edb0079cd32cee8668e80f6af61602c5c18dddd38e5d812fe3421dbae047"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-11236"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-11236""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-012_f919e1a0d432	MetaCyc:RXN-11236	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15377|MetaCyc:RXN-11236|MetaCyc:WATER	Coefficient 1; cytoplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-11236"", ""source_assertion"": ""The right side contains coefficient 1 of WATER in CCO-IN."", ""source_locator"": ""XPath /ptools-xml/Reaction/right[4]""}, {""reference_id"": ""MetaCyc:WATER"", ""source_assertion"": ""The native WATER object has InChI InChI=1S/H2O/h1H2."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:15377"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula H2O, charge 0."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:15377; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:15377"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""water"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:RXN-11236"", ""source_sha256"": ""6da8edb0079cd32cee8668e80f6af61602c5c18dddd38e5d812fe3421dbae047"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-11236"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-11236""}, {""id"": ""MetaCyc:WATER"", ""source_sha256"": ""29201d5730308535e65744b47f9f6e0eb3ef9ffdcdd2eb442888a34da8a8c366"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""H2O"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:WATER""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-013_aa403ba88b36	MetaCyc:TRANS-RXN0-239	RO:0002233	CHEBI:17632	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:17632|MetaCyc:NITRATE|MetaCyc:TRANS-RXN0-239	Coefficient 1; periplasmic side. Native compartmental equation and class identity retained. Formal antiport convention; exact PAO1 mode/catalyst is unassigned, not experimentally established stoichiometry.	"[{""reference_id"": ""MetaCyc:TRANS-RXN0-239"", ""source_assertion"": ""The left side contains coefficient 1 of NITRATE in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/left[1]""}, {""reference_id"": ""MetaCyc:NITRATE"", ""source_assertion"": ""The native NITRATE object has InChI InChI=1S/NO3/c2-1(3)4/q-1."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:17632"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula NO3, charge -1."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:17632; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:17632"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""nitrate"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:NITRATE"", ""source_sha256"": ""88035a8ef9ce4eb27070cb691f0197ded9e7d58f1deb6c3d6ade5a845247511f"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrate"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NITRATE""}, {""id"": ""MetaCyc:TRANS-RXN0-239"", ""source_sha256"": ""602f3c57783eaadf24024142ab4b7b44064ed001f05f776239462deb1a9e9837"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrate:nitrite antiport"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:TRANS-RXN0-239""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-014_c36aea5f20cc	MetaCyc:TRANS-RXN0-239	RO:0002233	CHEBI:16301	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:16301|MetaCyc:NITRITE|MetaCyc:TRANS-RXN0-239	Coefficient 1; cytoplasmic side. Native compartmental equation and class identity retained. Formal antiport convention; exact PAO1 mode/catalyst is unassigned, not experimentally established stoichiometry.	"[{""reference_id"": ""MetaCyc:TRANS-RXN0-239"", ""source_assertion"": ""The left side contains coefficient 1 of NITRITE in CCO-IN."", ""source_locator"": ""XPath /ptools-xml/Reaction/left[2]""}, {""reference_id"": ""MetaCyc:NITRITE"", ""source_assertion"": ""The native NITRITE object has InChI InChI=1S/HNO2/c2-1-3/h(H,2,3)/p-1."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:16301"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula NO2, charge -1."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:16301; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:16301"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""nitrite"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:NITRITE"", ""source_sha256"": ""ff43e11bd0ed78b0f1464af713b5976fced522f06b91cc176d718a816ae8f119"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrite"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NITRITE""}, {""id"": ""MetaCyc:TRANS-RXN0-239"", ""source_sha256"": ""602f3c57783eaadf24024142ab4b7b44064ed001f05f776239462deb1a9e9837"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrate:nitrite antiport"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:TRANS-RXN0-239""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-015_a99fed397539	MetaCyc:TRANS-RXN0-239	RO:0002234	CHEBI:17632	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:17632|MetaCyc:NITRATE|MetaCyc:TRANS-RXN0-239	Coefficient 1; cytoplasmic side. Native compartmental equation and class identity retained. Formal antiport convention; exact PAO1 mode/catalyst is unassigned, not experimentally established stoichiometry.	"[{""reference_id"": ""MetaCyc:TRANS-RXN0-239"", ""source_assertion"": ""The right side contains coefficient 1 of NITRATE in CCO-IN."", ""source_locator"": ""XPath /ptools-xml/Reaction/right[1]""}, {""reference_id"": ""MetaCyc:NITRATE"", ""source_assertion"": ""The native NITRATE object has InChI InChI=1S/NO3/c2-1(3)4/q-1."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:17632"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula NO3, charge -1."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:17632; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:17632"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""nitrate"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:NITRATE"", ""source_sha256"": ""88035a8ef9ce4eb27070cb691f0197ded9e7d58f1deb6c3d6ade5a845247511f"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrate"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NITRATE""}, {""id"": ""MetaCyc:TRANS-RXN0-239"", ""source_sha256"": ""602f3c57783eaadf24024142ab4b7b44064ed001f05f776239462deb1a9e9837"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrate:nitrite antiport"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:TRANS-RXN0-239""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-016_9f18e039076e	MetaCyc:TRANS-RXN0-239	RO:0002234	CHEBI:16301	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:16301|MetaCyc:NITRITE|MetaCyc:TRANS-RXN0-239	Coefficient 1; periplasmic side. Native compartmental equation and class identity retained. Formal antiport convention; exact PAO1 mode/catalyst is unassigned, not experimentally established stoichiometry.	"[{""reference_id"": ""MetaCyc:TRANS-RXN0-239"", ""source_assertion"": ""The right side contains coefficient 1 of NITRITE in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/right[2]""}, {""reference_id"": ""MetaCyc:NITRITE"", ""source_assertion"": ""The native NITRITE object has InChI InChI=1S/HNO2/c2-1-3/h(H,2,3)/p-1."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:16301"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula NO2, charge -1."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:16301; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:16301"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""nitrite"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:NITRITE"", ""source_sha256"": ""ff43e11bd0ed78b0f1464af713b5976fced522f06b91cc176d718a816ae8f119"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrite"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NITRITE""}, {""id"": ""MetaCyc:TRANS-RXN0-239"", ""source_sha256"": ""602f3c57783eaadf24024142ab4b7b44064ed001f05f776239462deb1a9e9837"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrate:nitrite antiport"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:TRANS-RXN0-239""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-017_996b7143624d	CHEBI:16301	pathwaymech:consumes	MetaCyc:RXN-15838	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:16301|MetaCyc:NITRITE|MetaCyc:RXN-15838	Coefficient 1; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-15838"", ""source_assertion"": ""The left side contains coefficient 1 of NITRITE in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/left[1]""}, {""reference_id"": ""MetaCyc:NITRITE"", ""source_assertion"": ""The native NITRITE object has InChI InChI=1S/HNO2/c2-1-3/h(H,2,3)/p-1."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:16301"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula NO2, charge -1."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:16301; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:16301"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""nitrite"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:NITRITE"", ""source_sha256"": ""ff43e11bd0ed78b0f1464af713b5976fced522f06b91cc176d718a816ae8f119"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrite"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NITRITE""}, {""id"": ""MetaCyc:RXN-15838"", ""source_sha256"": ""6fa3147ceb148eab4c076f4a9af4b0e2eb89985070ce5ae4799abd12e1883e20"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-15838"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-15838""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-018_87625268cb6d	MetaCyc:Reduced-cytochromes-c551	pathwaymech:consumes	MetaCyc:RXN-15838	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-15838|MetaCyc:Reduced-cytochromes-c551	Coefficient 1; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-15838"", ""source_assertion"": ""The left side contains coefficient 1 of Reduced-cytochromes-c551 in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/left[2]""}, {""reference_id"": ""MetaCyc:Reduced-cytochromes-c551"", ""source_assertion"": ""The issuing native object identifies this whole class as a reduced cytochrome c551; no unique molecular formula or sequence is asserted."", ""source_locator"": ""XPath /ptools-xml/Protein/common-name""}]"	"[{""id"": ""MetaCyc:RXN-15838"", ""source_sha256"": ""6fa3147ceb148eab4c076f4a9af4b0e2eb89985070ce5ae4799abd12e1883e20"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-15838"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-15838""}, {""id"": ""MetaCyc:Reduced-cytochromes-c551"", ""source_sha256"": ""8173045aba9230de2b907e824a692ab1aa4f7805319a26af7e7d99917000bcc4"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""a reduced cytochrome c551"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:Reduced-cytochromes-c551""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-019_218a83123ca9	CHEBI:15378	pathwaymech:consumes	MetaCyc:RXN-15838	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-15838	Coefficient 2; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-15838"", ""source_assertion"": ""The left side contains coefficient 2 of PROTON in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/left[3]""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native PROTON object has InChI InChI=1S/p+1."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula H, charge 1."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:15378; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""hydron"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""22115ac465b8f70fb4d34d11e93120cafb805cbc00c2391f21a5a27f1563602f"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""H+"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PROTON""}, {""id"": ""MetaCyc:RXN-15838"", ""source_sha256"": ""6fa3147ceb148eab4c076f4a9af4b0e2eb89985070ce5ae4799abd12e1883e20"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-15838"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-15838""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-020_011a80ebdd82	MetaCyc:RXN-15838	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15377|MetaCyc:RXN-15838|MetaCyc:WATER	Coefficient 1; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-15838"", ""source_assertion"": ""The right side contains coefficient 1 of WATER in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/right[1]""}, {""reference_id"": ""MetaCyc:WATER"", ""source_assertion"": ""The native WATER object has InChI InChI=1S/H2O/h1H2."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:15377"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula H2O, charge 0."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:15377; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:15377"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""water"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:RXN-15838"", ""source_sha256"": ""6fa3147ceb148eab4c076f4a9af4b0e2eb89985070ce5ae4799abd12e1883e20"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-15838"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-15838""}, {""id"": ""MetaCyc:WATER"", ""source_sha256"": ""29201d5730308535e65744b47f9f6e0eb3ef9ffdcdd2eb442888a34da8a8c366"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""H2O"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:WATER""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-021_105dbf75f9e3	MetaCyc:RXN-15838	pathwaymech:produces	CHEBI:16480	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:16480|MetaCyc:NITRIC-OXIDE|MetaCyc:RXN-15838	Coefficient 1; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-15838"", ""source_assertion"": ""The right side contains coefficient 1 of NITRIC-OXIDE in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/right[2]""}, {""reference_id"": ""MetaCyc:NITRIC-OXIDE"", ""source_assertion"": ""The native NITRIC-OXIDE object has InChI InChI=1S/NO/c1-2."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:16480"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula NO, charge 0."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:16480; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:16480"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""nitric oxide"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:NITRIC-OXIDE"", ""source_sha256"": ""968802112e77b75d29b05e4cf34149a218dcf8f507284c24360dbcc9b7ee5791"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitric oxide"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NITRIC-OXIDE""}, {""id"": ""MetaCyc:RXN-15838"", ""source_sha256"": ""6fa3147ceb148eab4c076f4a9af4b0e2eb89985070ce5ae4799abd12e1883e20"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-15838"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-15838""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-022_5e171b175f74	MetaCyc:RXN-15838	pathwaymech:produces	MetaCyc:Oxidized-cytochromes-c551	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Oxidized-cytochromes-c551|MetaCyc:RXN-15838	Coefficient 1; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-15838"", ""source_assertion"": ""The right side contains coefficient 1 of Oxidized-cytochromes-c551 in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/right[3]""}, {""reference_id"": ""MetaCyc:Oxidized-cytochromes-c551"", ""source_assertion"": ""The issuing native object identifies this whole class as an oxidized cytochrome c551; no unique molecular formula or sequence is asserted."", ""source_locator"": ""XPath /ptools-xml/Protein/common-name""}]"	"[{""id"": ""MetaCyc:Oxidized-cytochromes-c551"", ""source_sha256"": ""7283f474d053e902de1b544f8caed0d1fba3b1d6308a7be2ee6d97bee2c459dd"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""an oxidized cytochrome c551"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:Oxidized-cytochromes-c551""}, {""id"": ""MetaCyc:RXN-15838"", ""source_sha256"": ""6fa3147ceb148eab4c076f4a9af4b0e2eb89985070ce5ae4799abd12e1883e20"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-15838"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-15838""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-023_2cb3161e88f2	MetaCyc:Cytochromes-C-Reduced	pathwaymech:consumes	MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Cytochromes-C-Reduced|MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN	Coefficient 2; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN"", ""source_assertion"": ""The left side contains coefficient 2 of Cytochromes-C-Reduced in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/left[1]""}, {""reference_id"": ""MetaCyc:Cytochromes-C-Reduced"", ""source_assertion"": ""The issuing native object identifies this whole class as a reduced c-type cytochrome; no unique molecular formula or sequence is asserted."", ""source_locator"": ""XPath /ptools-xml/Protein/common-name""}]"	"[{""id"": ""MetaCyc:Cytochromes-C-Reduced"", ""source_sha256"": ""5c8dc58b9eef0d468bf5b4f649232a9c260cdb76bac9e2f0dc5745c686dec9ee"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""a reduced c-type cytochrome"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:Cytochromes-C-Reduced""}, {""id"": ""MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN"", ""source_sha256"": ""e112669b8190c419273b131c6cbb4bb52bbc0024dfb060789d95dc9767ce558d"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""NITRIC-OXIDE-REDUCTASE-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NITRIC-OXIDE-REDUCTASE-RXN""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-024_f29648324cd2	CHEBI:16480	pathwaymech:consumes	MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:16480|MetaCyc:NITRIC-OXIDE|MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN	Coefficient 2; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN"", ""source_assertion"": ""The left side contains coefficient 2 of NITRIC-OXIDE in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/left[2]""}, {""reference_id"": ""MetaCyc:NITRIC-OXIDE"", ""source_assertion"": ""The native NITRIC-OXIDE object has InChI InChI=1S/NO/c1-2."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:16480"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula NO, charge 0."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:16480; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:16480"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""nitric oxide"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:NITRIC-OXIDE"", ""source_sha256"": ""968802112e77b75d29b05e4cf34149a218dcf8f507284c24360dbcc9b7ee5791"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitric oxide"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NITRIC-OXIDE""}, {""id"": ""MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN"", ""source_sha256"": ""e112669b8190c419273b131c6cbb4bb52bbc0024dfb060789d95dc9767ce558d"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""NITRIC-OXIDE-REDUCTASE-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NITRIC-OXIDE-REDUCTASE-RXN""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-025_1d8ebdcab46d	CHEBI:15378	pathwaymech:consumes	MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN|MetaCyc:PROTON	Coefficient 2; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN"", ""source_assertion"": ""The left side contains coefficient 2 of PROTON in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/left[3]""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native PROTON object has InChI InChI=1S/p+1."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula H, charge 1."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:15378; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""hydron"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN"", ""source_sha256"": ""e112669b8190c419273b131c6cbb4bb52bbc0024dfb060789d95dc9767ce558d"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""NITRIC-OXIDE-REDUCTASE-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NITRIC-OXIDE-REDUCTASE-RXN""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""22115ac465b8f70fb4d34d11e93120cafb805cbc00c2391f21a5a27f1563602f"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""H+"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PROTON""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-026_2df660f45d16	MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN	pathwaymech:produces	CHEBI:17045	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:17045|MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN|MetaCyc:NITROUS-OXIDE	Coefficient 1; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN"", ""source_assertion"": ""The right side contains coefficient 1 of NITROUS-OXIDE in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/right[1]""}, {""reference_id"": ""MetaCyc:NITROUS-OXIDE"", ""source_assertion"": ""The native NITROUS-OXIDE object has InChI InChI=1S/N2O/c1-2-3."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:17045"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula N2O, charge 0."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:17045; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:17045"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""dinitrogen oxide"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN"", ""source_sha256"": ""e112669b8190c419273b131c6cbb4bb52bbc0024dfb060789d95dc9767ce558d"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""NITRIC-OXIDE-REDUCTASE-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NITRIC-OXIDE-REDUCTASE-RXN""}, {""id"": ""MetaCyc:NITROUS-OXIDE"", ""source_sha256"": ""4d229457dfba7651e75a518b36df05b5226bcb174a337cd16facc3b21660877a"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrous oxide"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NITROUS-OXIDE""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-027_9ceb8272af03	MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN	pathwaymech:produces	MetaCyc:Cytochromes-C-Oxidized	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Cytochromes-C-Oxidized|MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN	Coefficient 2; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN"", ""source_assertion"": ""The right side contains coefficient 2 of Cytochromes-C-Oxidized in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/right[2]""}, {""reference_id"": ""MetaCyc:Cytochromes-C-Oxidized"", ""source_assertion"": ""The issuing native object identifies this whole class as an oxidized c-type cytochrome; no unique molecular formula or sequence is asserted."", ""source_locator"": ""XPath /ptools-xml/Protein/common-name""}]"	"[{""id"": ""MetaCyc:Cytochromes-C-Oxidized"", ""source_sha256"": ""73fc0b11fc4e2739f287d197fa9a84b0eddb4d5d7d85757220c00a1b99f569af"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""an oxidized c-type cytochrome"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:Cytochromes-C-Oxidized""}, {""id"": ""MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN"", ""source_sha256"": ""e112669b8190c419273b131c6cbb4bb52bbc0024dfb060789d95dc9767ce558d"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""NITRIC-OXIDE-REDUCTASE-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NITRIC-OXIDE-REDUCTASE-RXN""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-028_99dd00e30b95	MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15377|MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN|MetaCyc:WATER	Coefficient 1; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN"", ""source_assertion"": ""The right side contains coefficient 1 of WATER in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/right[3]""}, {""reference_id"": ""MetaCyc:WATER"", ""source_assertion"": ""The native WATER object has InChI InChI=1S/H2O/h1H2."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:15377"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula H2O, charge 0."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:15377; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:15377"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""water"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN"", ""source_sha256"": ""e112669b8190c419273b131c6cbb4bb52bbc0024dfb060789d95dc9767ce558d"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""NITRIC-OXIDE-REDUCTASE-RXN"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NITRIC-OXIDE-REDUCTASE-RXN""}, {""id"": ""MetaCyc:WATER"", ""source_sha256"": ""29201d5730308535e65744b47f9f6e0eb3ef9ffdcdd2eb442888a34da8a8c366"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""H2O"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:WATER""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-029_aa559f0e3938	MetaCyc:Cytochromes-C-Reduced	pathwaymech:consumes	MetaCyc:RXN-12130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Cytochromes-C-Reduced|MetaCyc:RXN-12130	Coefficient 2; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-12130"", ""source_assertion"": ""The left side contains coefficient 2 of Cytochromes-C-Reduced in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/left[1]""}, {""reference_id"": ""MetaCyc:Cytochromes-C-Reduced"", ""source_assertion"": ""The issuing native object identifies this whole class as a reduced c-type cytochrome; no unique molecular formula or sequence is asserted."", ""source_locator"": ""XPath /ptools-xml/Protein/common-name""}]"	"[{""id"": ""MetaCyc:Cytochromes-C-Reduced"", ""source_sha256"": ""5c8dc58b9eef0d468bf5b4f649232a9c260cdb76bac9e2f0dc5745c686dec9ee"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""a reduced c-type cytochrome"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:Cytochromes-C-Reduced""}, {""id"": ""MetaCyc:RXN-12130"", ""source_sha256"": ""8713c9400dfbed65fa94ae17795b1fe69928d231491ea4d8747ec18bab7ac3bb"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-12130"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-12130""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-030_b818dd4ec3f8	CHEBI:17045	pathwaymech:consumes	MetaCyc:RXN-12130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:17045|MetaCyc:NITROUS-OXIDE|MetaCyc:RXN-12130	Coefficient 1; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-12130"", ""source_assertion"": ""The left side contains coefficient 1 of NITROUS-OXIDE in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/left[2]""}, {""reference_id"": ""MetaCyc:NITROUS-OXIDE"", ""source_assertion"": ""The native NITROUS-OXIDE object has InChI InChI=1S/N2O/c1-2-3."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:17045"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula N2O, charge 0."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:17045; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:17045"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""dinitrogen oxide"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:NITROUS-OXIDE"", ""source_sha256"": ""4d229457dfba7651e75a518b36df05b5226bcb174a337cd16facc3b21660877a"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrous oxide"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NITROUS-OXIDE""}, {""id"": ""MetaCyc:RXN-12130"", ""source_sha256"": ""8713c9400dfbed65fa94ae17795b1fe69928d231491ea4d8747ec18bab7ac3bb"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-12130"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-12130""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-031_0b746c29bd74	CHEBI:15378	pathwaymech:consumes	MetaCyc:RXN-12130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-12130	Coefficient 2; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-12130"", ""source_assertion"": ""The left side contains coefficient 2 of PROTON in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/left[3]""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native PROTON object has InChI InChI=1S/p+1."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula H, charge 1."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:15378; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""hydron"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""22115ac465b8f70fb4d34d11e93120cafb805cbc00c2391f21a5a27f1563602f"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""H+"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:PROTON""}, {""id"": ""MetaCyc:RXN-12130"", ""source_sha256"": ""8713c9400dfbed65fa94ae17795b1fe69928d231491ea4d8747ec18bab7ac3bb"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-12130"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-12130""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-032_eeef0acb5c5a	MetaCyc:RXN-12130	pathwaymech:produces	MetaCyc:Cytochromes-C-Oxidized	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Cytochromes-C-Oxidized|MetaCyc:RXN-12130	Coefficient 2; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-12130"", ""source_assertion"": ""The right side contains coefficient 2 of Cytochromes-C-Oxidized in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/right[1]""}, {""reference_id"": ""MetaCyc:Cytochromes-C-Oxidized"", ""source_assertion"": ""The issuing native object identifies this whole class as an oxidized c-type cytochrome; no unique molecular formula or sequence is asserted."", ""source_locator"": ""XPath /ptools-xml/Protein/common-name""}]"	"[{""id"": ""MetaCyc:Cytochromes-C-Oxidized"", ""source_sha256"": ""73fc0b11fc4e2739f287d197fa9a84b0eddb4d5d7d85757220c00a1b99f569af"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""an oxidized c-type cytochrome"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:Cytochromes-C-Oxidized""}, {""id"": ""MetaCyc:RXN-12130"", ""source_sha256"": ""8713c9400dfbed65fa94ae17795b1fe69928d231491ea4d8747ec18bab7ac3bb"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-12130"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-12130""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-033_3ea56712afcd	MetaCyc:RXN-12130	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15377|MetaCyc:RXN-12130|MetaCyc:WATER	Coefficient 1; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-12130"", ""source_assertion"": ""The right side contains coefficient 1 of WATER in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/right[2]""}, {""reference_id"": ""MetaCyc:WATER"", ""source_assertion"": ""The native WATER object has InChI InChI=1S/H2O/h1H2."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:15377"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula H2O, charge 0."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:15377; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:15377"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""water"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:RXN-12130"", ""source_sha256"": ""8713c9400dfbed65fa94ae17795b1fe69928d231491ea4d8747ec18bab7ac3bb"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-12130"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-12130""}, {""id"": ""MetaCyc:WATER"", ""source_sha256"": ""29201d5730308535e65744b47f9f6e0eb3ef9ffdcdd2eb442888a34da8a8c366"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""H2O"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:WATER""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-034_2b072caaff0f	MetaCyc:RXN-12130	pathwaymech:produces	CHEBI:17997	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:17997|MetaCyc:NITROGEN-MOLECULE|MetaCyc:RXN-12130	Coefficient 1; periplasmic side. Native compartmental equation and class identity retained.	"[{""reference_id"": ""MetaCyc:RXN-12130"", ""source_assertion"": ""The right side contains coefficient 1 of NITROGEN-MOLECULE in CCO-OUT."", ""source_locator"": ""XPath /ptools-xml/Reaction/right[3]""}, {""reference_id"": ""MetaCyc:NITROGEN-MOLECULE"", ""source_assertion"": ""The native NITROGEN-MOLECULE object has InChI InChI=1S/N2/c1-2."", ""source_locator"": ""XPath /ptools-xml/Compound/inchi""}, {""reference_id"": ""CHEBI:17997"", ""source_assertion"": ""The selected ChEBI structure has the same InChI; formula N2, charge 0."", ""source_locator"": ""Semantic SQL statements: subject=CHEBI:17997; chemrof:inchi_string, chemrof:generalized_empirical_formula, chemrof:charge""}]"	"[{""id"": ""CHEBI:17997"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""dinitrogen"", ""url"": ""http://purl.obolibrary.org/obo/chebi/255/chebi.owl""}, {""id"": ""MetaCyc:NITROGEN-MOLECULE"", ""source_sha256"": ""02bfc9749bd4457fa07ea8f0de0a79affcf8cbad7a4340efba40759f168219c3"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""N2"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:NITROGEN-MOLECULE""}, {""id"": ""MetaCyc:RXN-12130"", ""source_sha256"": ""8713c9400dfbed65fa94ae17795b1fe69928d231491ea4d8747ec18bab7ac3bb"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""RXN-12130"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:RXN-12130""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-035_7b3b3ac4d753	MetaCyc:RXN-11236	pathwaymech:precedes	MetaCyc:TRANS-RXN0-239	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DENITRIFICATION-PWY	Source-defined reaction ordering; transport is coupled to nitrate reduction and no exclusive temporal separation or in vivo flux is inferred.	"[{""reference_id"": ""MetaCyc:DENITRIFICATION-PWY"", ""source_assertion"": ""The reaction-ordering object identifies RXN-11236 as a predecessor of TRANS-RXN0-239."", ""source_locator"": ""XPath /ptools-xml/Pathway/reaction-ordering[Reaction/@frameid=\""TRANS-RXN0-239\""]""}]"	"[{""id"": ""MetaCyc:DENITRIFICATION-PWY"", ""source_sha256"": ""9a11dcba9fba820b150fa11cea42a9d1163739fdab59274bbe634714b612785a"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrate reduction I (denitrification)"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:DENITRIFICATION-PWY""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-036_cfa62de591ea	MetaCyc:TRANS-RXN0-239	pathwaymech:precedes	MetaCyc:RXN-15838	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DENITRIFICATION-PWY	Source-defined reaction ordering; transport is coupled to nitrate reduction and no exclusive temporal separation or in vivo flux is inferred.	"[{""reference_id"": ""MetaCyc:DENITRIFICATION-PWY"", ""source_assertion"": ""The reaction-ordering object identifies TRANS-RXN0-239 as a predecessor of RXN-15838."", ""source_locator"": ""XPath /ptools-xml/Pathway/reaction-ordering[Reaction/@frameid=\""RXN-15838\""]""}]"	"[{""id"": ""MetaCyc:DENITRIFICATION-PWY"", ""source_sha256"": ""9a11dcba9fba820b150fa11cea42a9d1163739fdab59274bbe634714b612785a"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrate reduction I (denitrification)"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:DENITRIFICATION-PWY""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-037_57b9f3e87db1	MetaCyc:RXN-15838	pathwaymech:precedes	MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DENITRIFICATION-PWY	Source-defined reaction ordering; transport is coupled to nitrate reduction and no exclusive temporal separation or in vivo flux is inferred.	"[{""reference_id"": ""MetaCyc:DENITRIFICATION-PWY"", ""source_assertion"": ""The reaction-ordering object identifies RXN-15838 as a predecessor of NITRIC-OXIDE-REDUCTASE-RXN."", ""source_locator"": ""XPath /ptools-xml/Pathway/reaction-ordering[Reaction/@frameid=\""NITRIC-OXIDE-REDUCTASE-RXN\""]""}]"	"[{""id"": ""MetaCyc:DENITRIFICATION-PWY"", ""source_sha256"": ""9a11dcba9fba820b150fa11cea42a9d1163739fdab59274bbe634714b612785a"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrate reduction I (denitrification)"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:DENITRIFICATION-PWY""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-038_fef90d2ba72d	MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN	pathwaymech:precedes	MetaCyc:RXN-12130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DENITRIFICATION-PWY	Source-defined reaction ordering; transport is coupled to nitrate reduction and no exclusive temporal separation or in vivo flux is inferred.	"[{""reference_id"": ""MetaCyc:DENITRIFICATION-PWY"", ""source_assertion"": ""The reaction-ordering object identifies NITRIC-OXIDE-REDUCTASE-RXN as a predecessor of RXN-12130."", ""source_locator"": ""XPath /ptools-xml/Pathway/reaction-ordering[Reaction/@frameid=\""RXN-12130\""]""}]"	"[{""id"": ""MetaCyc:DENITRIFICATION-PWY"", ""source_sha256"": ""9a11dcba9fba820b150fa11cea42a9d1163739fdab59274bbe634714b612785a"", ""source_version"": ""Original MetaCyc 27.0 XML; Pathway Tools 27.0; retrieved 2026-10-11; direct object scope"", ""title"": ""nitrate reduction I (denitrification)"", ""url"": ""https://bf2i-artsymbiocyc.insa-lyon.fr/getxml?id=META:DENITRIFICATION-PWY""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-039_2249540f66a9	UniProtKB:G3XCX1	pathwaymech:enables	MetaCyc:RXN-11236	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:16391109|UniProtKB:G3XCX1	Gene-product component of the Nar respiratory ensemble, not isolated-subunit catalysis. Current activity is ARBA inference; the source vectorial proton convention is not derived from that chemical-class annotation.	"[{""reference_id"": ""UniProtKB:G3XCX1"", ""source_assertion"": ""This current UniProtKB unreviewed (TrEMBL) entry assigns G3XCX1 to taxon 208964, narG / PA3875, with a 1261-residue sequence. It does not establish sequence identity to every historical preparation."", ""source_locator"": ""JSON pointer /primaryAccession; /organism/taxonId; /genes; /sequence""}, {""reference_id"": ""UniProtKB:G3XCX1"", ""source_assertion"": ""The unreviewed catalytic annotation cites Rhea 56144 with ECO:0000256 ARBA evidence; it supports the nitrate/quinol reaction class."", ""source_locator"": ""JSON pointer /comments/0""}, {""reference_id"": ""PMID:16391109"", ""source_assertion"": ""PAO1 narG mutant showed no nitrate uptake, connecting intracellular nitrite generation with uptake; this is physiological coupling, not a purified subunit assay."", ""source_locator"": ""XPath //article/section[2]/section/section[4]/p[3]""}]"	"[{""id"": ""PMID:16391109"", ""source_sha256"": ""1faa67e8157884747e253b3aef423e8d6f9038e7e4921e3793e3afc2e25ed132"", ""source_version"": ""Original PMC primary HTML; full article inspected; retrieved 2026-10-11"", ""title"": ""Involvement of NarK1 and NarK2 Proteins in Transport of Nitrate and Nitrite in the Denitrifying Bacterium Pseudomonas aeruginosa PAO1"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1352271/""}, {""id"": ""UniProtKB:G3XCX1"", ""source_sha256"": ""6e171d54814ec625096a9e49156dadf2b4638fb7fe4ddf1e954e7ad950d45771"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB unreviewed (TrEMBL); entryAudit {\""entryVersion\"": 84, \""firstPublicDate\"": \""2011-11-16\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2011-11-16\"", \""sequenceVersion\"": 1}"", ""title"": ""nitrate reductase (quinone)"", ""url"": ""https://rest.uniprot.org/uniprotkb/G3XCX1.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-040_8852a2a9744d	UniProtKB:G3XD87	pathwaymech:enables	MetaCyc:RXN-11236	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:16391109|UniProtKB:G3XD87	Gene-product component of the Nar respiratory ensemble, not isolated-subunit catalysis. Current activity is ARBA inference; the source vectorial proton convention is not derived from that chemical-class annotation.	"[{""reference_id"": ""UniProtKB:G3XD87"", ""source_assertion"": ""This current UniProtKB unreviewed (TrEMBL) entry assigns G3XD87 to taxon 208964, narH / PA3874, with a 513-residue sequence. It does not establish sequence identity to every historical preparation."", ""source_locator"": ""JSON pointer /primaryAccession; /organism/taxonId; /genes; /sequence""}, {""reference_id"": ""UniProtKB:G3XD87"", ""source_assertion"": ""The unreviewed catalytic annotation cites Rhea 56144 with ECO:0000256 ARBA evidence; it supports the nitrate/quinol reaction class."", ""source_locator"": ""JSON pointer /comments/0""}, {""reference_id"": ""PMID:16391109"", ""source_assertion"": ""PAO1 narG mutant showed no nitrate uptake, connecting intracellular nitrite generation with uptake; this is physiological coupling, not a purified subunit assay."", ""source_locator"": ""XPath //article/section[2]/section/section[4]/p[3]""}]"	"[{""id"": ""PMID:16391109"", ""source_sha256"": ""1faa67e8157884747e253b3aef423e8d6f9038e7e4921e3793e3afc2e25ed132"", ""source_version"": ""Original PMC primary HTML; full article inspected; retrieved 2026-10-11"", ""title"": ""Involvement of NarK1 and NarK2 Proteins in Transport of Nitrate and Nitrite in the Denitrifying Bacterium Pseudomonas aeruginosa PAO1"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1352271/""}, {""id"": ""UniProtKB:G3XD87"", ""source_sha256"": ""32782faec4c5b0d4d0b94615aefd75286544b564912c7335619b42a8a8099aaa"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB unreviewed (TrEMBL); entryAudit {\""entryVersion\"": 67, \""firstPublicDate\"": \""2011-11-16\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2011-11-16\"", \""sequenceVersion\"": 1}"", ""title"": ""nitrate reductase (quinone)"", ""url"": ""https://rest.uniprot.org/uniprotkb/G3XD87.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-041_c17f59674a3a	UniProtKB:G3XD18	pathwaymech:enables	MetaCyc:RXN-11236	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:16391109|UniProtKB:G3XD18	Gene-product component of the Nar respiratory ensemble, not isolated-subunit catalysis. Current activity is ARBA inference; the source vectorial proton convention is not derived from that chemical-class annotation.	"[{""reference_id"": ""UniProtKB:G3XD18"", ""source_assertion"": ""This current UniProtKB unreviewed (TrEMBL) entry assigns G3XD18 to taxon 208964, narI / PA3872, with a 227-residue sequence. It does not establish sequence identity to every historical preparation."", ""source_locator"": ""JSON pointer /primaryAccession; /organism/taxonId; /genes; /sequence""}, {""reference_id"": ""UniProtKB:G3XD18"", ""source_assertion"": ""The unreviewed catalytic annotation cites Rhea 56144 with ECO:0000256 ARBA evidence; it supports the nitrate/quinol reaction class."", ""source_locator"": ""JSON pointer /comments/0""}, {""reference_id"": ""PMID:16391109"", ""source_assertion"": ""PAO1 narG mutant showed no nitrate uptake, connecting intracellular nitrite generation with uptake; this is physiological coupling, not a purified subunit assay."", ""source_locator"": ""XPath //article/section[2]/section/section[4]/p[3]""}]"	"[{""id"": ""PMID:16391109"", ""source_sha256"": ""1faa67e8157884747e253b3aef423e8d6f9038e7e4921e3793e3afc2e25ed132"", ""source_version"": ""Original PMC primary HTML; full article inspected; retrieved 2026-10-11"", ""title"": ""Involvement of NarK1 and NarK2 Proteins in Transport of Nitrate and Nitrite in the Denitrifying Bacterium Pseudomonas aeruginosa PAO1"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1352271/""}, {""id"": ""UniProtKB:G3XD18"", ""source_sha256"": ""fd5235ea80703da6c53ddf9d8df535ddaec824b572dbd1bf451964aae89c1fbc"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB unreviewed (TrEMBL); entryAudit {\""entryVersion\"": 66, \""firstPublicDate\"": \""2011-11-16\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2011-11-16\"", \""sequenceVersion\"": 1}"", ""title"": ""nitrate reductase (quinone)"", ""url"": ""https://rest.uniprot.org/uniprotkb/G3XD18.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-042_f65f3a45b36e	UniProtKB:P24474	pathwaymech:enables	MetaCyc:RXN-15838	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:25386171|UniProtKB:P24474	Current NirS nitrite-reductase activity with source c551 donor convention; the protein is reported as a homodimer, but no other-species MetaCyc complex ID is transferred.	"[{""reference_id"": ""UniProtKB:P24474"", ""source_assertion"": ""This current UniProtKB reviewed (Swiss-Prot) entry assigns P24474 to taxon 208964, nirS / PA0519, with a 568-residue sequence. It does not establish sequence identity to every historical preparation."", ""source_locator"": ""JSON pointer /primaryAccession; /organism/taxonId; /genes; /sequence""}, {""reference_id"": ""UniProtKB:P24474"", ""source_assertion"": ""The reviewed entry records nitrite-reductase catalytic activity (Rhea 15233) and homodimeric subunit organization. The Rhea class uses generic cytochrome c, broader than native c551."", ""source_locator"": ""JSON pointer /comments/0; /comments/4""}, {""reference_id"": ""PMID:25386171"", ""source_assertion"": ""The study distinguishes PAO0001 reporter PAO1 from Holloway PAO1 wild-type and its nirS-N and nosZ deletion mutants; these are physiological strain preparations, not sequence-exact recombinant NirS assays."", ""source_locator"": ""XPath /article/body/sec[2]/sec[1]/p[1]""}]"	"[{""id"": ""PMID:25386171"", ""source_sha256"": ""47813db7b761f3b16b41e6a538829e62b40a2dcbbee167c4b35b2b4aa1677d0e"", ""source_version"": ""Original full primary JATS from Europe PMC; retrieved 2026-10-11"", ""title"": ""Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4208399/fullTextXML""}, {""id"": ""UniProtKB:P24474"", ""source_sha256"": ""4218a827c8a1211550989ac226ca149a82b180ea00f944f06b725b8db82c5421"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 177, \""firstPublicDate\"": \""1992-03-01\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""1992-03-01\"", \""sequenceVersion\"": 1}"", ""title"": ""Nitrite reductase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P24474.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-043_dd45672992db	UniProtKB:Q59647	pathwaymech:enables	MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1126/science.1195591|DOI:10.2210/pdb3o0r/pdb|PMID:21109633|UniProtKB:Q59647	Subunit function in the NorBC ensemble, not isolated-subunit catalysis. Current NorB proton-pump prose is excluded. RCSB 3O0R PAO1 preparations differ from current sequences (NorB lacks current R301; NorC K100 versus N100), so no exact construct equivalence is asserted.	"[{""reference_id"": ""UniProtKB:Q59647"", ""source_assertion"": ""This current UniProtKB reviewed (Swiss-Prot) entry assigns Q59647 to taxon 208964, norB / PA0524, with a 466-residue sequence. It does not establish sequence identity to every historical preparation."", ""source_locator"": ""JSON pointer /primaryAccession; /organism/taxonId; /genes; /sequence""}, {""reference_id"": ""UniProtKB:Q59647"", ""source_assertion"": ""The reviewed entry describes a heterodimer consisting of a large cytochrome b subunit and a small cytochrome c subunit."", ""source_locator"": ""JSON pointer /comments/3""}, {""reference_id"": ""UniProtKB:Q59647"", ""source_assertion"": ""The catalytic annotation is Rhea 30211, a cytochrome-c NO/N2O reaction class; reduction proceeds in its reverse direction."", ""source_locator"": ""JSON pointer /comments/1""}, {""reference_id"": ""PMID:21109633"", ""source_assertion"": ""The primary abstract reports a P. aeruginosa NOR structure, an FeB center with three His and one Glu ligands, and no D- or K-proton pathway; extracellular proton delivery is proposed."", ""source_locator"": ""XPath //result[id=\""21109633\""]/abstractText""}, {""reference_id"": ""DOI:10.2210/pdb3o0r/pdb"", ""source_assertion"": ""The mmCIF assigns entity 3, NorB, a 465-residue sequence and natural PAO1 source."", ""source_locator"": ""CIF category _entity_poly.; _entity_src_nat.""}, {""reference_id"": ""UniProtKB:Q59647"", ""source_assertion"": ""The inferred FUNCTION annotation (ECO:0000250) states proton-pump activity. This source statement is retained as a conflict and is not adopted as a transport or energy-coupling assertion."", ""source_locator"": ""JSON pointer /comments/0""}, {""reference_id"": ""DOI:10.1126/science.1195591"", ""source_assertion"": ""The structural discussion states that no obvious D/K proton-pumping channel or hydrogen-bond network connects cytoplasm and periplasm, consistent with cNOR lacking proton-pumping ability."", ""source_locator"": ""Original author-uploaded main article, Science 330 pp.1666–1670 (2010), final structural discussion paragraph beginning “Considering the regions of cNOR”; Figure 4 context; web-inspected text, no local full-text body""}]"	"[{""id"": ""DOI:10.1126/science.1195591"", ""source_version"": ""Original author-uploaded main article inspected through web on 2026-10-11; publisher PDF/SI returned 403 and author download failed; no local full-text digest claimed"", ""title"": ""Structural Basis of Biological N2O Generation by Bacterial Nitric Oxide Reductase"", ""url"": ""https://www.researchgate.net/publication/49637682_Structural_Basis_of_Biological_N_2_O_Generation_by_Bacterial_Nitric_Oxide_Reductase""}, {""id"": ""DOI:10.2210/pdb3o0r/pdb"", ""source_sha256"": ""e7aebd9b2278186159b4af8120f302df9a0c9c38269ae96862b916217cae2c05"", ""source_version"": ""Original complete PDB mmCIF; revision 2.0, 2026-08-12; source natural PAO1, sequence differences retained"", ""title"": ""Crystal structure of nitric oxide reductase from Pseudomonas aeruginosa in complex with antibody fragment"", ""url"": ""https://files.rcsb.org/download/3O0R.cif""}, {""id"": ""PMID:21109633"", ""source_sha256"": ""98130f6f6588aacc8ad3dfd4627ae45b0dab5bc051f8fb4b7046fb1c1266d4ed"", ""source_version"": ""Original Europe PMC indexed primary abstract/metadata; not full article"", ""title"": ""Structural basis of biological N2O generation by bacterial nitric oxide reductase."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15504726%20OR%20EXT_ID:9331415%20OR%20EXT_ID:7711073%20OR%20EXT_ID:21109633&format=xml&resultType=core&pageSize=100""}, {""id"": ""UniProtKB:Q59647"", ""source_sha256"": ""8e8fc5e36e910dfa71fc3a5b5e9a038e36997dd3e616ef894e0abf5339fd11f5"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 155, \""firstPublicDate\"": \""1997-11-01\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""1996-11-01\"", \""sequenceVersion\"": 1}"", ""title"": ""Nitric oxide reductase subunit B"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q59647.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-044_ca6d0ab1fc09	UniProtKB:Q59646	pathwaymech:enables	MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.2210/pdb3o0r/pdb|PMID:21109633|UniProtKB:Q59646	Subunit function in the NorBC ensemble, not isolated-subunit catalysis. Current NorB proton-pump prose is excluded. RCSB 3O0R PAO1 preparations differ from current sequences (NorB lacks current R301; NorC K100 versus N100), so no exact construct equivalence is asserted.	"[{""reference_id"": ""UniProtKB:Q59646"", ""source_assertion"": ""This current UniProtKB reviewed (Swiss-Prot) entry assigns Q59646 to taxon 208964, norC / PA0523, with a 146-residue sequence. It does not establish sequence identity to every historical preparation."", ""source_locator"": ""JSON pointer /primaryAccession; /organism/taxonId; /genes; /sequence""}, {""reference_id"": ""UniProtKB:Q59646"", ""source_assertion"": ""The reviewed entry describes a heterodimer consisting of a large cytochrome b subunit and a small cytochrome c subunit."", ""source_locator"": ""JSON pointer /comments/1""}, {""reference_id"": ""PMID:21109633"", ""source_assertion"": ""The primary abstract reports a P. aeruginosa NOR structure, an FeB center with three His and one Glu ligands, and no D- or K-proton pathway; extracellular proton delivery is proposed."", ""source_locator"": ""XPath //result[id=\""21109633\""]/abstractText""}, {""reference_id"": ""DOI:10.2210/pdb3o0r/pdb"", ""source_assertion"": ""The mmCIF assigns entity 4, NorC, a 146-residue sequence including K100 and natural PAO1 source."", ""source_locator"": ""CIF category _entity_poly.; _entity_src_nat.""}]"	"[{""id"": ""DOI:10.2210/pdb3o0r/pdb"", ""source_sha256"": ""e7aebd9b2278186159b4af8120f302df9a0c9c38269ae96862b916217cae2c05"", ""source_version"": ""Original complete PDB mmCIF; revision 2.0, 2026-08-12; source natural PAO1, sequence differences retained"", ""title"": ""Crystal structure of nitric oxide reductase from Pseudomonas aeruginosa in complex with antibody fragment"", ""url"": ""https://files.rcsb.org/download/3O0R.cif""}, {""id"": ""PMID:21109633"", ""source_sha256"": ""98130f6f6588aacc8ad3dfd4627ae45b0dab5bc051f8fb4b7046fb1c1266d4ed"", ""source_version"": ""Original Europe PMC indexed primary abstract/metadata; not full article"", ""title"": ""Structural basis of biological N2O generation by bacterial nitric oxide reductase."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15504726%20OR%20EXT_ID:9331415%20OR%20EXT_ID:7711073%20OR%20EXT_ID:21109633&format=xml&resultType=core&pageSize=100""}, {""id"": ""UniProtKB:Q59646"", ""source_sha256"": ""37d2906f62695578ee11081bd28c00eba6976d93b45ecac1c75b2e42ccc79d41"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 160, \""firstPublicDate\"": \""1998-12-15\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2007-01-23\"", \""sequenceVersion\"": 3}"", ""title"": ""Nitric oxide reductase subunit C"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q59646.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-045_14f9956ccb2a	UniProtKB:Q9HYL2	pathwaymech:enables	MetaCyc:RXN-12130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:25386171|PMID:30093706|UniProtKB:Q9HYL2	NosZ activity is annotated by HAMAP; PAO1 deletion physiology independently supports terminal N2O reduction. Generic c-type electron donor is a source reaction convention, not a uniquely identified physiological partner.	"[{""reference_id"": ""UniProtKB:Q9HYL2"", ""source_assertion"": ""This current UniProtKB reviewed (Swiss-Prot) entry assigns Q9HYL2 to taxon 208964, nosZ / PA3392, with a 636-residue sequence. It does not establish sequence identity to every historical preparation."", ""source_locator"": ""JSON pointer /primaryAccession; /organism/taxonId; /genes; /sequence""}, {""reference_id"": ""UniProtKB:Q9HYL2"", ""source_assertion"": ""The entry assigns nitrous-oxide reductase activity (Rhea 43108) using ECO:0000255 HAMAP-Rule MF_00716."", ""source_locator"": ""JSON pointer /comments/1""}, {""reference_id"": ""PMID:30093706"", ""source_assertion"": ""The PAO1 nosZ deletion strain accumulates N2O during denitrification; NosZ loss is the engineered physiological block."", ""source_locator"": ""XPath /article/body/sec[2]/sec[1]/p[2]""}, {""reference_id"": ""PMID:25386171"", ""source_assertion"": ""The nosZ mutant accumulates N2O under anoxia, whereas wild-type PAO1 produces less than 10 micromolar N2O under the experimental nitrate concentrations."", ""source_locator"": ""XPath /article/body/sec[3]/sec[4]/p""}]"	"[{""id"": ""PMID:25386171"", ""source_sha256"": ""47813db7b761f3b16b41e6a538829e62b40a2dcbbee167c4b35b2b4aa1677d0e"", ""source_version"": ""Original full primary JATS from Europe PMC; retrieved 2026-10-11"", ""title"": ""Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4208399/fullTextXML""}, {""id"": ""PMID:30093706"", ""source_sha256"": ""999c5fb6ab0f282291411c42857b331fb484200e879c02a45d2873bfcab39b61"", ""source_version"": ""Original full primary JATS from Europe PMC; retrieved 2026-10-11"", ""title"": ""Significant enhancement of nitrous oxide energy yields from wastewater achieved by bioaugmentation with a recombinant strain of Pseudomonas aeruginosa"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6085377/fullTextXML""}, {""id"": ""UniProtKB:Q9HYL2"", ""source_sha256"": ""a29d06aeae242834d252bc9485c95937ab764387415bfa215abf87a38d0b719e"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 150, \""firstPublicDate\"": \""2001-01-11\"", \""lastAnnotationUpdateDate\"": \""2026-06-10\"", \""lastSequenceUpdateDate\"": \""2001-01-11\"", \""sequenceVersion\"": 1}"", ""title"": ""Nitrous-oxide reductase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9HYL2.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-046_6f3971acc0a5	UniProtKB:Q9HXD4	pathwaymech:enables	MetaCyc:DENITRIFICATION-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:16391109|UniProtKB:Q9HXD4	Nitrate/nitrite transport contribution to the complete pathway; this edge does not assign strict 1:1 antiport or isolated exact transport stoichiometry. NarK2 has the dominant phenotype and NarK1 a smaller contribution in the tested PAO1 conditions.	"[{""reference_id"": ""UniProtKB:Q9HXD4"", ""source_assertion"": ""This current UniProtKB unreviewed (TrEMBL) entry assigns Q9HXD4 to taxon 208964, narK2 / PA3876, with a 468-residue sequence. It does not establish sequence identity to every historical preparation."", ""source_locator"": ""JSON pointer /primaryAccession; /organism/taxonId; /genes; /sequence""}, {""reference_id"": ""PMID:16391109"", ""source_assertion"": ""PAO1 narK1 deletion only slightly affected anaerobic growth, while narK2 and double deletion were severely compromised; all mutants retained nitrate-reductase activity."", ""source_locator"": ""XPath //article/section[2]/section/section[4]/p[2]""}, {""reference_id"": ""PMID:16391109"", ""source_assertion"": ""The authors explicitly leave antiport versus uniport experimentally unresolved."", ""source_locator"": ""XPath //article/section[2]/section/section[4]/p[5]""}]"	"[{""id"": ""PMID:16391109"", ""source_sha256"": ""1faa67e8157884747e253b3aef423e8d6f9038e7e4921e3793e3afc2e25ed132"", ""source_version"": ""Original PMC primary HTML; full article inspected; retrieved 2026-10-11"", ""title"": ""Involvement of NarK1 and NarK2 Proteins in Transport of Nitrate and Nitrite in the Denitrifying Bacterium Pseudomonas aeruginosa PAO1"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1352271/""}, {""id"": ""UniProtKB:Q9HXD4"", ""source_sha256"": ""8556e161e7ecc529d8c37031e844ba14454d4e9f27665d2ad2ab9603820599fd"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB unreviewed (TrEMBL); entryAudit {\""entryVersion\"": 117, \""firstPublicDate\"": \""2001-03-01\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2001-03-01\"", \""sequenceVersion\"": 1}"", ""title"": ""Nitrate/nitrite transporter"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9HXD4.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-047_7723d9ad5b7e	UniProtKB:G3XD60	pathwaymech:enables	MetaCyc:DENITRIFICATION-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:16391109|UniProtKB:G3XD60	Nitrate/nitrite transport contribution to the complete pathway; this edge does not assign strict 1:1 antiport or isolated exact transport stoichiometry. NarK2 has the dominant phenotype and NarK1 a smaller contribution in the tested PAO1 conditions.	"[{""reference_id"": ""UniProtKB:G3XD60"", ""source_assertion"": ""This current UniProtKB unreviewed (TrEMBL) entry assigns G3XD60 to taxon 208964, narK1 / PA3877, with a 431-residue sequence. It does not establish sequence identity to every historical preparation."", ""source_locator"": ""JSON pointer /primaryAccession; /organism/taxonId; /genes; /sequence""}, {""reference_id"": ""PMID:16391109"", ""source_assertion"": ""PAO1 narK1 deletion only slightly affected anaerobic growth, while narK2 and double deletion were severely compromised; all mutants retained nitrate-reductase activity."", ""source_locator"": ""XPath //article/section[2]/section/section[4]/p[2]""}, {""reference_id"": ""PMID:16391109"", ""source_assertion"": ""The authors explicitly leave antiport versus uniport experimentally unresolved."", ""source_locator"": ""XPath //article/section[2]/section/section[4]/p[5]""}]"	"[{""id"": ""PMID:16391109"", ""source_sha256"": ""1faa67e8157884747e253b3aef423e8d6f9038e7e4921e3793e3afc2e25ed132"", ""source_version"": ""Original PMC primary HTML; full article inspected; retrieved 2026-10-11"", ""title"": ""Involvement of NarK1 and NarK2 Proteins in Transport of Nitrate and Nitrite in the Denitrifying Bacterium Pseudomonas aeruginosa PAO1"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1352271/""}, {""id"": ""UniProtKB:G3XD60"", ""source_sha256"": ""8893eea1324dacbac408cfe7f4851268f34cbe1e65817734923442ca66856eb7"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB unreviewed (TrEMBL); entryAudit {\""entryVersion\"": 66, \""firstPublicDate\"": \""2011-11-16\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2011-11-16\"", \""sequenceVersion\"": 1}"", ""title"": ""Nitrite extrusion protein 1"", ""url"": ""https://rest.uniprot.org/uniprotkb/G3XD60.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-048_59559b13aa28	UniProtKB:P00099	pathwaymech:enables	MetaCyc:RXN-15838	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00099	NirM electron-donor contribution to nitrite reduction, not catalytic nitrite-reductase assignment. The whole c551 redox classes remain distinct from the sequence entry.	"[{""reference_id"": ""UniProtKB:P00099"", ""source_assertion"": ""This current UniProtKB reviewed (Swiss-Prot) entry assigns P00099 to taxon 208964, nirM / PA0518, with a 104-residue sequence. It does not establish sequence identity to every historical preparation."", ""source_locator"": ""JSON pointer /primaryAccession; /organism/taxonId; /genes; /sequence""}, {""reference_id"": ""UniProtKB:P00099"", ""source_assertion"": ""The reviewed entry identifies cytochrome c-551 as an electron donor for cytochrome cd1 in nitrite and nitrate respiration."", ""source_locator"": ""JSON pointer /comments/0""}]"	"[{""id"": ""UniProtKB:P00099"", ""source_sha256"": ""d127745a3b8e559188927b2c30b1695a8b8649f30d3239a4d49ac5b838d4e8aa"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 175, \""firstPublicDate\"": \""1986-07-21\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""1990-04-01\"", \""sequenceVersion\"": 2}"", ""title"": ""Cytochrome c-551"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00099.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-049_a28a1f206b65	UniProtKB:G3XCX1	pathwaymech:has_cofactor	CHEBI:60539	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:G3XCX1	Current entry annotation of Mo-bisMGD; ECO:0000256 ARBA. Issuing cofactor-state identifier is retained without asserting a fixed redox state throughout catalysis or direct measurement in every PAO1 preparation.	"[{""reference_id"": ""UniProtKB:G3XCX1"", ""source_assertion"": ""The exact annotation records Mo-bisMGD with ECO:0000256 ARBA; the selected ChEBI cofactor identifier is the entry-assigned ligand identity."", ""source_locator"": ""JSON pointer /comments/1""}]"	"[{""id"": ""UniProtKB:G3XCX1"", ""source_sha256"": ""6e171d54814ec625096a9e49156dadf2b4638fb7fe4ddf1e954e7ad950d45771"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB unreviewed (TrEMBL); entryAudit {\""entryVersion\"": 84, \""firstPublicDate\"": \""2011-11-16\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2011-11-16\"", \""sequenceVersion\"": 1}"", ""title"": ""nitrate reductase (quinone)"", ""url"": ""https://rest.uniprot.org/uniprotkb/G3XCX1.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-050_59271110b891	UniProtKB:G3XCX1	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:G3XCX1	Current entry annotation of [4Fe-4S]; ECO:0000256 ARBA. Issuing cofactor-state identifier is retained without asserting a fixed redox state throughout catalysis or direct measurement in every PAO1 preparation.	"[{""reference_id"": ""UniProtKB:G3XCX1"", ""source_assertion"": ""The exact annotation records [4Fe-4S] with ECO:0000256 ARBA; the selected ChEBI cofactor identifier is the entry-assigned ligand identity."", ""source_locator"": ""JSON pointer /comments/2""}]"	"[{""id"": ""UniProtKB:G3XCX1"", ""source_sha256"": ""6e171d54814ec625096a9e49156dadf2b4638fb7fe4ddf1e954e7ad950d45771"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB unreviewed (TrEMBL); entryAudit {\""entryVersion\"": 84, \""firstPublicDate\"": \""2011-11-16\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2011-11-16\"", \""sequenceVersion\"": 1}"", ""title"": ""nitrate reductase (quinone)"", ""url"": ""https://rest.uniprot.org/uniprotkb/G3XCX1.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-051_087f2a94c715	UniProtKB:G3XD87	pathwaymech:has_cofactor	CHEBI:21137	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:G3XD87	Current entry annotation of [3Fe-4S]; ECO:0000256 ARBA. Issuing cofactor-state identifier is retained without asserting a fixed redox state throughout catalysis or direct measurement in every PAO1 preparation.	"[{""reference_id"": ""UniProtKB:G3XD87"", ""source_assertion"": ""The exact annotation records [3Fe-4S] with ECO:0000256 ARBA; the selected ChEBI cofactor identifier is the entry-assigned ligand identity."", ""source_locator"": ""JSON pointer /comments/1""}]"	"[{""id"": ""UniProtKB:G3XD87"", ""source_sha256"": ""32782faec4c5b0d4d0b94615aefd75286544b564912c7335619b42a8a8099aaa"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB unreviewed (TrEMBL); entryAudit {\""entryVersion\"": 67, \""firstPublicDate\"": \""2011-11-16\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2011-11-16\"", \""sequenceVersion\"": 1}"", ""title"": ""nitrate reductase (quinone)"", ""url"": ""https://rest.uniprot.org/uniprotkb/G3XD87.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-052_fe4d3f7aeaf3	UniProtKB:G3XD87	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:G3XD87	Current entry annotation of [4Fe-4S]; ECO:0000256 ARBA. Issuing cofactor-state identifier is retained without asserting a fixed redox state throughout catalysis or direct measurement in every PAO1 preparation.	"[{""reference_id"": ""UniProtKB:G3XD87"", ""source_assertion"": ""The exact annotation records [4Fe-4S] with ECO:0000256 ARBA; the selected ChEBI cofactor identifier is the entry-assigned ligand identity."", ""source_locator"": ""JSON pointer /comments/2""}]"	"[{""id"": ""UniProtKB:G3XD87"", ""source_sha256"": ""32782faec4c5b0d4d0b94615aefd75286544b564912c7335619b42a8a8099aaa"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB unreviewed (TrEMBL); entryAudit {\""entryVersion\"": 67, \""firstPublicDate\"": \""2011-11-16\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2011-11-16\"", \""sequenceVersion\"": 1}"", ""title"": ""nitrate reductase (quinone)"", ""url"": ""https://rest.uniprot.org/uniprotkb/G3XD87.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-053_ba075e9fafbf	UniProtKB:G3XD18	pathwaymech:has_cofactor	CHEBI:60344	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:G3XD18	Current entry annotation of heme b; ECO:0000256 PIRSR. Issuing cofactor-state identifier is retained without asserting a fixed redox state throughout catalysis or direct measurement in every PAO1 preparation.	"[{""reference_id"": ""UniProtKB:G3XD18"", ""source_assertion"": ""The exact annotation records heme b with ECO:0000256 PIRSR; the selected ChEBI cofactor identifier is the entry-assigned ligand identity."", ""source_locator"": ""JSON pointer /features/6""}]"	"[{""id"": ""UniProtKB:G3XD18"", ""source_sha256"": ""fd5235ea80703da6c53ddf9d8df535ddaec824b572dbd1bf451964aae89c1fbc"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB unreviewed (TrEMBL); entryAudit {\""entryVersion\"": 66, \""firstPublicDate\"": \""2011-11-16\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2011-11-16\"", \""sequenceVersion\"": 1}"", ""title"": ""nitrate reductase (quinone)"", ""url"": ""https://rest.uniprot.org/uniprotkb/G3XD18.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-054_30abc9098e33	UniProtKB:P24474	pathwaymech:has_cofactor	CHEBI:61717	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P24474	Current entry annotation of heme c; ECO:0000269 PMID9331415. Issuing cofactor-state identifier is retained without asserting a fixed redox state throughout catalysis or direct measurement in every PAO1 preparation.	"[{""reference_id"": ""UniProtKB:P24474"", ""source_assertion"": ""The exact annotation records heme c with ECO:0000269 PMID9331415; the selected ChEBI cofactor identifier is the entry-assigned ligand identity."", ""source_locator"": ""JSON pointer /comments/2""}]"	"[{""id"": ""UniProtKB:P24474"", ""source_sha256"": ""4218a827c8a1211550989ac226ca149a82b180ea00f944f06b725b8db82c5421"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 177, \""firstPublicDate\"": \""1992-03-01\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""1992-03-01\"", \""sequenceVersion\"": 1}"", ""title"": ""Nitrite reductase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P24474.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-055_9cd5a91c809b	UniProtKB:P24474	pathwaymech:has_cofactor	CHEBI:60549	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P24474	Current entry annotation of heme d1; ECO:0000269 PMID9331415 and PDB mapping. Issuing cofactor-state identifier is retained without asserting a fixed redox state throughout catalysis or direct measurement in every PAO1 preparation.	"[{""reference_id"": ""UniProtKB:P24474"", ""source_assertion"": ""The exact annotation records heme d1 with ECO:0000269 PMID9331415 and PDB mapping; the selected ChEBI cofactor identifier is the entry-assigned ligand identity."", ""source_locator"": ""JSON pointer /features/11""}]"	"[{""id"": ""UniProtKB:P24474"", ""source_sha256"": ""4218a827c8a1211550989ac226ca149a82b180ea00f944f06b725b8db82c5421"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 177, \""firstPublicDate\"": \""1992-03-01\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""1992-03-01\"", \""sequenceVersion\"": 1}"", ""title"": ""Nitrite reductase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P24474.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-056_7058d1696a5d	UniProtKB:Q59647	pathwaymech:has_cofactor	CHEBI:60344	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q59647	Current entry annotation of heme b; ECO:0000305 curator inference. Issuing cofactor-state identifier is retained without asserting a fixed redox state throughout catalysis or direct measurement in every PAO1 preparation.	"[{""reference_id"": ""UniProtKB:Q59647"", ""source_assertion"": ""The exact annotation records heme b with ECO:0000305 curator inference; the selected ChEBI cofactor identifier is the entry-assigned ligand identity."", ""source_locator"": ""JSON pointer /features/13""}]"	"[{""id"": ""UniProtKB:Q59647"", ""source_sha256"": ""8e8fc5e36e910dfa71fc3a5b5e9a038e36997dd3e616ef894e0abf5339fd11f5"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 155, \""firstPublicDate\"": \""1997-11-01\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""1996-11-01\"", \""sequenceVersion\"": 1}"", ""title"": ""Nitric oxide reductase subunit B"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q59647.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-057_dbfeac5b5b1c	UniProtKB:Q59647	pathwaymech:has_cofactor	CHEBI:24875	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q59647	Current entry annotation of non-heme Fe cation; ECO:0000305 curator inference. Issuing cofactor-state identifier is retained without asserting a fixed redox state throughout catalysis or direct measurement in every PAO1 preparation.	"[{""reference_id"": ""UniProtKB:Q59647"", ""source_assertion"": ""The exact annotation records non-heme Fe cation with ECO:0000305 curator inference; the selected ChEBI cofactor identifier is the entry-assigned ligand identity."", ""source_locator"": ""JSON pointer /features/14""}]"	"[{""id"": ""UniProtKB:Q59647"", ""source_sha256"": ""8e8fc5e36e910dfa71fc3a5b5e9a038e36997dd3e616ef894e0abf5339fd11f5"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 155, \""firstPublicDate\"": \""1997-11-01\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""1996-11-01\"", \""sequenceVersion\"": 1}"", ""title"": ""Nitric oxide reductase subunit B"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q59647.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-058_9a5928d0c663	UniProtKB:Q59646	pathwaymech:has_cofactor	CHEBI:61717	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q59646	Current entry annotation of heme c; ECO:0000255 PROSITE. Issuing cofactor-state identifier is retained without asserting a fixed redox state throughout catalysis or direct measurement in every PAO1 preparation.	"[{""reference_id"": ""UniProtKB:Q59646"", ""source_assertion"": ""The exact annotation records heme c with ECO:0000255 PROSITE; the selected ChEBI cofactor identifier is the entry-assigned ligand identity."", ""source_locator"": ""JSON pointer /features/3""}]"	"[{""id"": ""UniProtKB:Q59646"", ""source_sha256"": ""37d2906f62695578ee11081bd28c00eba6976d93b45ecac1c75b2e42ccc79d41"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 160, \""firstPublicDate\"": \""1998-12-15\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2007-01-23\"", \""sequenceVersion\"": 3}"", ""title"": ""Nitric oxide reductase subunit C"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q59646.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-059_0510d4f70c40	UniProtKB:Q9HYL2	pathwaymech:has_cofactor	CHEBI:47357	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q9HYL2	Current entry annotation of CuA binuclear copper center; ECO:0000255 HAMAP. Issuing cofactor-state identifier is retained without asserting a fixed redox state throughout catalysis or direct measurement in every PAO1 preparation.	"[{""reference_id"": ""UniProtKB:Q9HYL2"", ""source_assertion"": ""The exact annotation records CuA binuclear copper center with ECO:0000255 HAMAP; the selected ChEBI cofactor identifier is the entry-assigned ligand identity."", ""source_locator"": ""JSON pointer /comments/2""}]"	"[{""id"": ""UniProtKB:Q9HYL2"", ""source_sha256"": ""a29d06aeae242834d252bc9485c95937ab764387415bfa215abf87a38d0b719e"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 150, \""firstPublicDate\"": \""2001-01-11\"", \""lastAnnotationUpdateDate\"": \""2026-06-10\"", \""lastSequenceUpdateDate\"": \""2001-01-11\"", \""sequenceVersion\"": 1}"", ""title"": ""Nitrous-oxide reductase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9HYL2.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-060_0bec35aac91d	UniProtKB:Q9HYL2	pathwaymech:has_cofactor	CHEBI:33730	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q9HYL2	Current entry annotation of CuZ [4Cu-S] cluster; ECO:0000255 HAMAP. Issuing cofactor-state identifier is retained without asserting a fixed redox state throughout catalysis or direct measurement in every PAO1 preparation.	"[{""reference_id"": ""UniProtKB:Q9HYL2"", ""source_assertion"": ""The exact annotation records CuZ [4Cu-S] cluster with ECO:0000255 HAMAP; the selected ChEBI cofactor identifier is the entry-assigned ligand identity."", ""source_locator"": ""JSON pointer /comments/3""}]"	"[{""id"": ""UniProtKB:Q9HYL2"", ""source_sha256"": ""a29d06aeae242834d252bc9485c95937ab764387415bfa215abf87a38d0b719e"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 150, \""firstPublicDate\"": \""2001-01-11\"", \""lastAnnotationUpdateDate\"": \""2026-06-10\"", \""lastSequenceUpdateDate\"": \""2001-01-11\"", \""sequenceVersion\"": 1}"", ""title"": ""Nitrous-oxide reductase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9HYL2.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-061_a694483971f6	UniProtKB:Q9HYL2	pathwaymech:has_cofactor	CHEBI:29108	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q9HYL2	Current entry annotation of Ca2+; ECO:0000255 HAMAP. Issuing cofactor-state identifier is retained without asserting a fixed redox state throughout catalysis or direct measurement in every PAO1 preparation.	"[{""reference_id"": ""UniProtKB:Q9HYL2"", ""source_assertion"": ""The exact annotation records Ca2+ with ECO:0000255 HAMAP; the selected ChEBI cofactor identifier is the entry-assigned ligand identity."", ""source_locator"": ""JSON pointer /comments/4""}]"	"[{""id"": ""UniProtKB:Q9HYL2"", ""source_sha256"": ""a29d06aeae242834d252bc9485c95937ab764387415bfa215abf87a38d0b719e"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 150, \""firstPublicDate\"": \""2001-01-11\"", \""lastAnnotationUpdateDate\"": \""2026-06-10\"", \""lastSequenceUpdateDate\"": \""2001-01-11\"", \""sequenceVersion\"": 1}"", ""title"": ""Nitrous-oxide reductase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9HYL2.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-062_932555f26aa6	UniProtKB:P00099	pathwaymech:has_cofactor	CHEBI:61717	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00099	Covalently attached heme c; the whole redox carrier is retained separately. Current heme annotation does not assert a permanently reduced in vivo state.	"[{""reference_id"": ""UniProtKB:P00099"", ""source_assertion"": ""The entry states that one heme c group is covalently bound per subunit."", ""source_locator"": ""JSON pointer /comments/3""}, {""reference_id"": ""UniProtKB:P00099"", ""source_assertion"": ""The current cytochrome c-551 heme-binding feature assigns CHEBI:61717."", ""source_locator"": ""JSON pointer /features/2""}]"	"[{""id"": ""UniProtKB:P00099"", ""source_sha256"": ""d127745a3b8e559188927b2c30b1695a8b8649f30d3239a4d49ac5b838d4e8aa"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 175, \""firstPublicDate\"": \""1986-07-21\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""1990-04-01\"", \""sequenceVersion\"": 2}"", ""title"": ""Cytochrome c-551"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00099.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-063_05430a0031c7	UniProtKB:P23926	pathwaymech:regulates	MetaCyc:DENITRIFICATION-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:17400734|UniProtKB:P23926	Expression-level regulatory support under tested PAO1 nitrate/anaerobic conditions; no direct catalytic activation/inhibition or IHF CHA-A2 strain transfer is inferred.	"[{""reference_id"": ""UniProtKB:P23926"", ""source_assertion"": ""This current UniProtKB reviewed (Swiss-Prot) entry assigns P23926 to taxon 208964, anr / PA1544, with a 244-residue sequence. It does not establish sequence identity to every historical preparation."", ""source_locator"": ""JSON pointer /primaryAccession; /organism/taxonId; /genes; /sequence""}, {""reference_id"": ""PMID:17400734"", ""source_assertion"": ""Anr is essential for anaerobic narK1 promoter activity; promoter motif mutation and complementation support the expression effect."", ""source_locator"": ""XPath //article/section[2]/section/section[4]/p[position() >= 1 and position() <= 2]""}]"	"[{""id"": ""PMID:17400734"", ""source_sha256"": ""7150f45d2c45df096fc514697d412bea71e38993fc6b787eddcec48a2fd1425f"", ""source_version"": ""Original PMC primary HTML; full article inspected; retrieved 2026-10-11"", ""title"": ""The Anaerobic Regulatory Network Required for Pseudomonas aeruginosa Nitrate Respiration"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1913380/""}, {""id"": ""UniProtKB:P23926"", ""source_sha256"": ""67ecfca36c26334660b3996199dfc593ae762b1f1f7f717f2d716fef31a715f7"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 152, \""firstPublicDate\"": \""1992-03-01\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""1992-03-01\"", \""sequenceVersion\"": 1}"", ""title"": ""Transcriptional activator protein anr"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23926.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-064_bcafce16bfd4	UniProtKB:G3XCW6	pathwaymech:regulates	MetaCyc:DENITRIFICATION-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:17400734|UniProtKB:G3XCW6	Expression-level regulatory support under tested PAO1 nitrate/anaerobic conditions; no direct catalytic activation/inhibition or IHF CHA-A2 strain transfer is inferred.	"[{""reference_id"": ""UniProtKB:G3XCW6"", ""source_assertion"": ""This current UniProtKB unreviewed (TrEMBL) entry assigns G3XCW6 to taxon 208964, dnr / PA0527, with a 227-residue sequence. It does not establish sequence identity to every historical preparation."", ""source_locator"": ""JSON pointer /primaryAccession; /organism/taxonId; /genes; /sequence""}, {""reference_id"": ""PMID:17400734"", ""source_assertion"": ""Dnr deletion decreases anaerobic narK1 promoter activity and complementation supports an enhancing expression role."", ""source_locator"": ""XPath //article/section[2]/section/section[4]/p[1]""}]"	"[{""id"": ""PMID:17400734"", ""source_sha256"": ""7150f45d2c45df096fc514697d412bea71e38993fc6b787eddcec48a2fd1425f"", ""source_version"": ""Original PMC primary HTML; full article inspected; retrieved 2026-10-11"", ""title"": ""The Anaerobic Regulatory Network Required for Pseudomonas aeruginosa Nitrate Respiration"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1913380/""}, {""id"": ""UniProtKB:G3XCW6"", ""source_sha256"": ""d6eda39d66971a97701ee01b781b0f7aa25fde559d874172e6530ce67f7465fe"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB unreviewed (TrEMBL); entryAudit {\""entryVersion\"": 85, \""firstPublicDate\"": \""2011-11-16\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2011-11-16\"", \""sequenceVersion\"": 1}"", ""title"": ""Transcriptional regulator Dnr"", ""url"": ""https://rest.uniprot.org/uniprotkb/G3XCW6.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-065_1f9556a09ecb	UniProtKB:Q9HXD3	pathwaymech:regulates	MetaCyc:DENITRIFICATION-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:17400734|UniProtKB:Q9HXD3	Expression-level regulatory support under tested PAO1 nitrate/anaerobic conditions; no direct catalytic activation/inhibition or IHF CHA-A2 strain transfer is inferred.	"[{""reference_id"": ""UniProtKB:Q9HXD3"", ""source_assertion"": ""This current UniProtKB unreviewed (TrEMBL) entry assigns Q9HXD3 to taxon 208964, narL / PA3879, with a 219-residue sequence. It does not establish sequence identity to every historical preparation."", ""source_locator"": ""JSON pointer /primaryAccession; /organism/taxonId; /genes; /sequence""}, {""reference_id"": ""PMID:17400734"", ""source_assertion"": ""NarL deletion lowers narK1 promoter activity, complementation nearly restores it, and selected promoter-site mutations abolish reporter activity."", ""source_locator"": ""XPath //article/section[2]/section/section[4]/p[2]""}]"	"[{""id"": ""PMID:17400734"", ""source_sha256"": ""7150f45d2c45df096fc514697d412bea71e38993fc6b787eddcec48a2fd1425f"", ""source_version"": ""Original PMC primary HTML; full article inspected; retrieved 2026-10-11"", ""title"": ""The Anaerobic Regulatory Network Required for Pseudomonas aeruginosa Nitrate Respiration"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC1913380/""}, {""id"": ""UniProtKB:Q9HXD3"", ""source_sha256"": ""23593855bcf277a2ceaef3369711f16b288e884dd3e7f59b3f0ec0195108b982"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB unreviewed (TrEMBL); entryAudit {\""entryVersion\"": 152, \""firstPublicDate\"": \""2001-03-01\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2001-03-01\"", \""sequenceVersion\"": 1}"", ""title"": ""Two-component response regulator NarL"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9HXD3.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-066_a7e0b42faa73	UniProtKB:P24474	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P24474	Current entry localization; inferred/rule-based scope remains as in the cited source. Membrane role does not itself demonstrate proton pumping.	"[{""reference_id"": ""UniProtKB:P24474"", ""source_assertion"": ""The subcellular-location annotation places the protein in the periplasm."", ""source_locator"": ""JSON pointer /comments/5""}]"	"[{""id"": ""UniProtKB:P24474"", ""source_sha256"": ""4218a827c8a1211550989ac226ca149a82b180ea00f944f06b725b8db82c5421"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 177, \""firstPublicDate\"": \""1992-03-01\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""1992-03-01\"", \""sequenceVersion\"": 1}"", ""title"": ""Nitrite reductase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P24474.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-067_b27f455e1052	UniProtKB:Q59647	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q59647	Current entry localization; inferred/rule-based scope remains as in the cited source. Membrane role does not itself demonstrate proton pumping.	"[{""reference_id"": ""UniProtKB:Q59647"", ""source_assertion"": ""The subcellular-location annotation places the protein in the cell/inner membrane."", ""source_locator"": ""JSON pointer /comments/4""}]"	"[{""id"": ""UniProtKB:Q59647"", ""source_sha256"": ""8e8fc5e36e910dfa71fc3a5b5e9a038e36997dd3e616ef894e0abf5339fd11f5"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 155, \""firstPublicDate\"": \""1997-11-01\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""1996-11-01\"", \""sequenceVersion\"": 1}"", ""title"": ""Nitric oxide reductase subunit B"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q59647.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-068_d2be6fd45861	UniProtKB:Q59646	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q59646	Current entry localization; inferred/rule-based scope remains as in the cited source. Membrane role does not itself demonstrate proton pumping.	"[{""reference_id"": ""UniProtKB:Q59646"", ""source_assertion"": ""The subcellular-location annotation places the protein in the cell/inner membrane."", ""source_locator"": ""JSON pointer /comments/2""}]"	"[{""id"": ""UniProtKB:Q59646"", ""source_sha256"": ""37d2906f62695578ee11081bd28c00eba6976d93b45ecac1c75b2e42ccc79d41"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 160, \""firstPublicDate\"": \""1998-12-15\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2007-01-23\"", \""sequenceVersion\"": 3}"", ""title"": ""Nitric oxide reductase subunit C"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q59646.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-069_88e6e295eac1	UniProtKB:Q9HYL2	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q9HYL2	Current entry localization; inferred/rule-based scope remains as in the cited source. Membrane role does not itself demonstrate proton pumping.	"[{""reference_id"": ""UniProtKB:Q9HYL2"", ""source_assertion"": ""The subcellular-location annotation places the protein in the periplasm."", ""source_locator"": ""JSON pointer /comments/7""}]"	"[{""id"": ""UniProtKB:Q9HYL2"", ""source_sha256"": ""a29d06aeae242834d252bc9485c95937ab764387415bfa215abf87a38d0b719e"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 150, \""firstPublicDate\"": \""2001-01-11\"", \""lastAnnotationUpdateDate\"": \""2026-06-10\"", \""lastSequenceUpdateDate\"": \""2001-01-11\"", \""sequenceVersion\"": 1}"", ""title"": ""Nitrous-oxide reductase"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9HYL2.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-070_0c335a6571e2	UniProtKB:G3XCX1	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:G3XCX1	Current entry localization; inferred/rule-based scope remains as in the cited source. Membrane role does not itself demonstrate proton pumping.	"[{""reference_id"": ""UniProtKB:G3XCX1"", ""source_assertion"": ""The subcellular-location annotation places the protein in the cell/inner membrane."", ""source_locator"": ""JSON pointer /comments/3""}]"	"[{""id"": ""UniProtKB:G3XCX1"", ""source_sha256"": ""6e171d54814ec625096a9e49156dadf2b4638fb7fe4ddf1e954e7ad950d45771"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB unreviewed (TrEMBL); entryAudit {\""entryVersion\"": 84, \""firstPublicDate\"": \""2011-11-16\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2011-11-16\"", \""sequenceVersion\"": 1}"", ""title"": ""nitrate reductase (quinone)"", ""url"": ""https://rest.uniprot.org/uniprotkb/G3XCX1.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-071_645711937784	UniProtKB:G3XD87	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:G3XD87	Current entry localization; inferred/rule-based scope remains as in the cited source. Membrane role does not itself demonstrate proton pumping.	"[{""reference_id"": ""UniProtKB:G3XD87"", ""source_assertion"": ""The subcellular-location annotation places the protein in the cell/inner membrane."", ""source_locator"": ""JSON pointer /comments/4""}]"	"[{""id"": ""UniProtKB:G3XD87"", ""source_sha256"": ""32782faec4c5b0d4d0b94615aefd75286544b564912c7335619b42a8a8099aaa"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB unreviewed (TrEMBL); entryAudit {\""entryVersion\"": 67, \""firstPublicDate\"": \""2011-11-16\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2011-11-16\"", \""sequenceVersion\"": 1}"", ""title"": ""nitrate reductase (quinone)"", ""url"": ""https://rest.uniprot.org/uniprotkb/G3XD87.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-072_2b1086f1afe1	UniProtKB:G3XD18	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:G3XD18	Current entry localization; inferred/rule-based scope remains as in the cited source. Membrane role does not itself demonstrate proton pumping.	"[{""reference_id"": ""UniProtKB:G3XD18"", ""source_assertion"": ""The subcellular-location annotation places the protein in the cell/inner membrane."", ""source_locator"": ""JSON pointer /comments/3""}]"	"[{""id"": ""UniProtKB:G3XD18"", ""source_sha256"": ""fd5235ea80703da6c53ddf9d8df535ddaec824b572dbd1bf451964aae89c1fbc"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB unreviewed (TrEMBL); entryAudit {\""entryVersion\"": 66, \""firstPublicDate\"": \""2011-11-16\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2011-11-16\"", \""sequenceVersion\"": 1}"", ""title"": ""nitrate reductase (quinone)"", ""url"": ""https://rest.uniprot.org/uniprotkb/G3XD18.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-073_b8a8ecc21298	UniProtKB:Q9HXD4	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q9HXD4	Current entry localization; inferred/rule-based scope remains as in the cited source. Membrane role does not itself demonstrate proton pumping.	"[{""reference_id"": ""UniProtKB:Q9HXD4"", ""source_assertion"": ""The subcellular-location annotation places the protein in the cell/inner membrane."", ""source_locator"": ""JSON pointer /comments/0""}]"	"[{""id"": ""UniProtKB:Q9HXD4"", ""source_sha256"": ""8556e161e7ecc529d8c37031e844ba14454d4e9f27665d2ad2ab9603820599fd"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB unreviewed (TrEMBL); entryAudit {\""entryVersion\"": 117, \""firstPublicDate\"": \""2001-03-01\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2001-03-01\"", \""sequenceVersion\"": 1}"", ""title"": ""Nitrate/nitrite transporter"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q9HXD4.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-074_633cebd82051	UniProtKB:G3XD60	RO:0001025	GO:0016020	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0016020|UniProtKB:G3XD60	Generic membrane localization and multipass topology are inferred by ARBA (ECO:0000256). The current entry does not specify the inner/plasma membrane; no direct localization assay or proton-pumping role is inferred.	"[{""reference_id"": ""UniProtKB:G3XD60"", ""source_assertion"": ""The entry annotates Membrane and Multi-pass membrane protein with ECO:0000256 ARBA00004141. Its GO cross-reference is GO:0016020 membrane, with IEA:UniProtKB-SubCell; this does not specify the inner/plasma membrane."", ""source_locator"": ""JSON pointer /comments/0; /uniProtKBCrossReferences/18""}, {""reference_id"": ""GO:0016020"", ""source_assertion"": ""The issuing active GO cellular-component term is membrane, defined as a lipid bilayer with embedded or attached proteins and complexes. This generic term does not assert plasma-membrane specificity."", ""source_locator"": ""Semantic SQL statements: subject=GO:0016020; rdfs:label, IAO:0000115, oio:hasOBONamespace""}]"	"[{""id"": ""GO:0016020"", ""source_sha256"": ""018a7ef0a5bd1c0767abc3d71b413264a25be7579533daf5349f739cd9a122cd"", ""source_version"": ""GO 2026-07-26; SHA256 covers original complete uncompressed Semantic SQL database"", ""title"": ""membrane"", ""url"": ""http://purl.obolibrary.org/obo/go/releases/2026-07-26/extensions/go-plus.ofn""}, {""id"": ""UniProtKB:G3XD60"", ""source_sha256"": ""8893eea1324dacbac408cfe7f4851268f34cbe1e65817734923442ca66856eb7"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB unreviewed (TrEMBL); entryAudit {\""entryVersion\"": 66, \""firstPublicDate\"": \""2011-11-16\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""2011-11-16\"", \""sequenceVersion\"": 1}"", ""title"": ""Nitrite extrusion protein 1"", ""url"": ""https://rest.uniprot.org/uniprotkb/G3XD60.json""}]"	""
pathwaymech:MetaCyc_DENITRIFICATION-PWY_denitrification-edge-075_c23350cc5233	UniProtKB:P00099	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00099	Current entry localization; inferred/rule-based scope remains as in the cited source. Membrane role does not itself demonstrate proton pumping.	"[{""reference_id"": ""UniProtKB:P00099"", ""source_assertion"": ""The subcellular-location annotation places the protein in the periplasm."", ""source_locator"": ""JSON pointer /comments/2""}]"	"[{""id"": ""UniProtKB:P00099"", ""source_sha256"": ""d127745a3b8e559188927b2c30b1695a8b8649f30d3239a4d49ac5b838d4e8aa"", ""source_version"": ""Original UniProt JSON retrieved 2026-10-11; UniProtKB reviewed (Swiss-Prot); entryAudit {\""entryVersion\"": 175, \""firstPublicDate\"": \""1986-07-21\"", \""lastAnnotationUpdateDate\"": \""2026-09-02\"", \""lastSequenceUpdateDate\"": \""1990-04-01\"", \""sequenceVersion\"": 2}"", ""title"": ""Cytochrome c-551"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00099.json""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_edge-001_8effe5b8af83	SGD:S000003780	pathwaymech:enables	gomodel:RXN-9666	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-5268		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_assertion"": ""The model asserts gomodel:RXN-9666 RO:0002333 gomodel:YeastPathways_PWY3O-5268/67c10cc400000524."", ""source_locator"": ""./YeastPathways_PWY3O-5268.json#/facts/0; endpoint types: /individuals/11/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-03-04; member ./YeastPathways_PWY3O-5268.json"", ""title"": ""GO-CAM oleate biosynthesis model YeastPathways_PWY3O-5268"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_edge-002_3700ece9698b	gomodel:1.14.19.1-RXN	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-5268		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_assertion"": ""The model asserts gomodel:1.14.19.1-RXN RO:0002234 gomodel:CHEBI_15377_1.14.19.1-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-5268.json#/facts/1; endpoint types: /individuals/30/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-03-04; member ./YeastPathways_PWY3O-5268.json"", ""title"": ""GO-CAM oleate biosynthesis model YeastPathways_PWY3O-5268"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_edge-003_3748882bf53b	gomodel:1.14.19.1-RXN	RO:0002233	CHEBI:57394	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-5268		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_assertion"": ""The model asserts gomodel:1.14.19.1-RXN RO:0002233 gomodel:CHEBI_57394_1.14.19.1-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-5268.json#/facts/2; endpoint types: /individuals/30/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-03-04; member ./YeastPathways_PWY3O-5268.json"", ""title"": ""GO-CAM oleate biosynthesis model YeastPathways_PWY3O-5268"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_edge-004_afd781281ec8	gomodel:RXN-9666	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-5268		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_assertion"": ""The model asserts gomodel:RXN-9666 RO:0002234 gomodel:CHEBI_57287_RXN-9666."", ""source_locator"": ""./YeastPathways_PWY3O-5268.json#/facts/3; endpoint types: /individuals/11/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-03-04; member ./YeastPathways_PWY3O-5268.json"", ""title"": ""GO-CAM oleate biosynthesis model YeastPathways_PWY3O-5268"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_edge-005_95f4caadbcf4	gomodel:1.14.19.1-RXN	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-5268		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_assertion"": ""The model asserts gomodel:1.14.19.1-RXN RO:0002233 gomodel:CHEBI_15379_1.14.19.1-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-5268.json#/facts/4; endpoint types: /individuals/30/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-03-04; member ./YeastPathways_PWY3O-5268.json"", ""title"": ""GO-CAM oleate biosynthesis model YeastPathways_PWY3O-5268"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_edge-006_f0b96855dc09	gomodel:RXN-9666	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-5268		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_assertion"": ""The model asserts gomodel:RXN-9666 RO:0002234 gomodel:CHEBI_15378_RXN-9666."", ""source_locator"": ""./YeastPathways_PWY3O-5268.json#/facts/5; endpoint types: /individuals/11/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-03-04; member ./YeastPathways_PWY3O-5268.json"", ""title"": ""GO-CAM oleate biosynthesis model YeastPathways_PWY3O-5268"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_edge-008_f6e43537bdc7	gomodel:RXN-9666	BFO:0000050	GO:0006636	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-5268		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_assertion"": ""The model asserts gomodel:RXN-9666 BFO:0000050 gomodel:YeastPathways_PWY3O-5268/YeastPathways_PWY3O-5268."", ""source_locator"": ""./YeastPathways_PWY3O-5268.json#/facts/7; endpoint types: /individuals/11/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-03-04; member ./YeastPathways_PWY3O-5268.json"", ""title"": ""GO-CAM oleate biosynthesis model YeastPathways_PWY3O-5268"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_edge-009_7dc7c3817209	gomodel:1.14.19.1-RXN	RO:0002233	gomodel:FERROCYTOCHROME-B5_1.14.19.1-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-5268		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_assertion"": ""The model asserts gomodel:1.14.19.1-RXN RO:0002233 gomodel:FERROCYTOCHROME-B5_1.14.19.1-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-5268.json#/facts/8; endpoint types: /individuals/30/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-03-04; member ./YeastPathways_PWY3O-5268.json"", ""title"": ""GO-CAM oleate biosynthesis model YeastPathways_PWY3O-5268"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_edge-010_ce9af5c14a14	gomodel:1.14.19.1-RXN	BFO:0000050	GO:0006636	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-5268		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_assertion"": ""The model asserts gomodel:1.14.19.1-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-5268/YeastPathways_PWY3O-5268."", ""source_locator"": ""./YeastPathways_PWY3O-5268.json#/facts/9; endpoint types: /individuals/30/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-03-04; member ./YeastPathways_PWY3O-5268.json"", ""title"": ""GO-CAM oleate biosynthesis model YeastPathways_PWY3O-5268"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_edge-012_4429ca00130a	gomodel:1.14.19.1-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-5268		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_assertion"": ""The model asserts gomodel:1.14.19.1-RXN RO:0002233 gomodel:CHEBI_15378_1.14.19.1-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-5268.json#/facts/11; endpoint types: /individuals/30/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-03-04; member ./YeastPathways_PWY3O-5268.json"", ""title"": ""GO-CAM oleate biosynthesis model YeastPathways_PWY3O-5268"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_edge-013_12b61d59e5d7	gomodel:RXN-9666	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-5268		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_assertion"": ""The model asserts gomodel:RXN-9666 RO:0002233 gomodel:CHEBI_15377_RXN-9666."", ""source_locator"": ""./YeastPathways_PWY3O-5268.json#/facts/12; endpoint types: /individuals/11/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-03-04; member ./YeastPathways_PWY3O-5268.json"", ""title"": ""GO-CAM oleate biosynthesis model YeastPathways_PWY3O-5268"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_edge-014_7be9ba249432	gomodel:RXN-9666	RO:0002234	CHEBI:30823	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-5268		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_assertion"": ""The model asserts gomodel:RXN-9666 RO:0002234 gomodel:CHEBI_30823_RXN-9666."", ""source_locator"": ""./YeastPathways_PWY3O-5268.json#/facts/13; endpoint types: /individuals/11/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-03-04; member ./YeastPathways_PWY3O-5268.json"", ""title"": ""GO-CAM oleate biosynthesis model YeastPathways_PWY3O-5268"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_edge-015_3faf06698f19	SGD:S000003023	pathwaymech:enables	gomodel:1.14.19.1-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-5268		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_assertion"": ""The model asserts gomodel:1.14.19.1-RXN RO:0002333 gomodel:YGL055W-MONOMER_1.14.19.1-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-5268.json#/facts/14; endpoint types: /individuals/30/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-03-04; member ./YeastPathways_PWY3O-5268.json"", ""title"": ""GO-CAM oleate biosynthesis model YeastPathways_PWY3O-5268"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_edge-016_ebcbc083eb98	gomodel:1.14.19.1-RXN	RO:0002234	gomodel:FERRICYTOCHROME-B5_1.14.19.1-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-5268		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_assertion"": ""The model asserts gomodel:1.14.19.1-RXN RO:0002234 gomodel:FERRICYTOCHROME-B5_1.14.19.1-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-5268.json#/facts/15; endpoint types: /individuals/30/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-03-04; member ./YeastPathways_PWY3O-5268.json"", ""title"": ""GO-CAM oleate biosynthesis model YeastPathways_PWY3O-5268"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_edge-017_fb0cb98ea171	gomodel:RXN-9666	RO:0002233	CHEBI:57387	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-5268		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_assertion"": ""The model asserts gomodel:RXN-9666 RO:0002233 gomodel:CHEBI_57387_1.14.19.1-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-5268.json#/facts/16; endpoint types: /individuals/11/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-03-04; member ./YeastPathways_PWY3O-5268.json"", ""title"": ""GO-CAM oleate biosynthesis model YeastPathways_PWY3O-5268"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_edge-018_ca833646c5f7	gomodel:1.14.19.1-RXN	RO:0002234	CHEBI:57387	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-5268		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_assertion"": ""The model asserts gomodel:1.14.19.1-RXN RO:0002234 gomodel:CHEBI_57387_1.14.19.1-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-5268.json#/facts/17; endpoint types: /individuals/30/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-5268"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-03-04; member ./YeastPathways_PWY3O-5268.json"", ""title"": ""GO-CAM oleate biosynthesis model YeastPathways_PWY3O-5268"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_location-3677ecc5d882_c9c1049df3c7	SGD:S000003780	RO:0001025	GO:0005777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41903	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10092594)	"[{""reference_id"": ""UniProtKB:P41903"", ""source_assertion"": ""UniProtKB:P41903 annotates location Peroxisome (SL-0204)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1826/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P41903"", ""source_assertion"": ""UniProtKB:P41903 has the exact SGD cross-reference SGD:S000003780."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1826/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P41903"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41903 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_location-8c643760a52d_eb084e8c2817	SGD:S000003023	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P21147	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:26928762) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P21147"", ""source_assertion"": ""UniProtKB:P21147 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/539/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P21147"", ""source_assertion"": ""UniProtKB:P21147 has the exact SGD cross-reference SGD:S000003023."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/539/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P21147"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P21147 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-5268_cofactor-896cc10c6831_b49d4692c0ac	SGD:S000003023	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P21147	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P13516) Expected to bind 2 Fe(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P13516)	"[{""reference_id"": ""UniProtKB:P21147"", ""source_assertion"": ""UniProtKB:P21147 annotates CHEBI:29033 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/539/comments/0/cofactors/0; /results/539/comments/0/note""}, {""reference_id"": ""UniProtKB:P21147"", ""source_assertion"": ""UniProtKB:P21147 has the exact SGD cross-reference SGD:S000003023."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/539/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P21147"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P21147 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_edge-001_fbbb9d49f334	gomodel:RXN-10664	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1801		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_assertion"": ""The model asserts gomodel:RXN-10664 RO:0002234 gomodel:CHEBI_15377_RXN-10664."", ""source_locator"": ""./YeastPathways_PWY3O-1801.json#/facts/0; endpoint types: /individuals/12/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-1801.json"", ""title"": ""GO-CAM palmitoleate biosynthesis model YeastPathways_PWY3O-1801"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_edge-002_70a99d4ee73f	gomodel:RXN-10662	BFO:0000050	GO:0006636	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1801		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_assertion"": ""The model asserts gomodel:RXN-10662 BFO:0000050 gomodel:YeastPathways_PWY3O-1801/YeastPathways_PWY3O-1801."", ""source_locator"": ""./YeastPathways_PWY3O-1801.json#/facts/1; endpoint types: /individuals/11/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-1801.json"", ""title"": ""GO-CAM palmitoleate biosynthesis model YeastPathways_PWY3O-1801"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_edge-003_6095aeb36f41	gomodel:RXN-10664	RO:0002234	CHEBI:61540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1801		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_assertion"": ""The model asserts gomodel:RXN-10664 RO:0002234 gomodel:CHEBI_61540_RXN-10664."", ""source_locator"": ""./YeastPathways_PWY3O-1801.json#/facts/2; endpoint types: /individuals/12/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-1801.json"", ""title"": ""GO-CAM palmitoleate biosynthesis model YeastPathways_PWY3O-1801"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_edge-004_9cd34c7bb497	gomodel:RXN-10662	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1801		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_assertion"": ""The model asserts gomodel:RXN-10662 RO:0002234 gomodel:CHEBI_15378_RXN-10662."", ""source_locator"": ""./YeastPathways_PWY3O-1801.json#/facts/3; endpoint types: /individuals/11/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-1801.json"", ""title"": ""GO-CAM palmitoleate biosynthesis model YeastPathways_PWY3O-1801"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_edge-005_5008dd6a16df	gomodel:RXN-10664	RO:0002234	gomodel:FERRICYTOCHROME-B5_RXN-10664	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1801		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_assertion"": ""The model asserts gomodel:RXN-10664 RO:0002234 gomodel:FERRICYTOCHROME-B5_RXN-10664."", ""source_locator"": ""./YeastPathways_PWY3O-1801.json#/facts/4; endpoint types: /individuals/12/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-1801.json"", ""title"": ""GO-CAM palmitoleate biosynthesis model YeastPathways_PWY3O-1801"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_edge-006_5baeef29082d	gomodel:RXN-10662	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1801		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_assertion"": ""The model asserts gomodel:RXN-10662 RO:0002233 gomodel:CHEBI_15377_RXN-10662."", ""source_locator"": ""./YeastPathways_PWY3O-1801.json#/facts/5; endpoint types: /individuals/11/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-1801.json"", ""title"": ""GO-CAM palmitoleate biosynthesis model YeastPathways_PWY3O-1801"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_edge-007_b1da9bb5830d	gomodel:RXN-10662	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1801		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_assertion"": ""The model asserts gomodel:RXN-10662 RO:0002234 gomodel:CHEBI_57287_RXN-10662."", ""source_locator"": ""./YeastPathways_PWY3O-1801.json#/facts/6; endpoint types: /individuals/11/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-1801.json"", ""title"": ""GO-CAM palmitoleate biosynthesis model YeastPathways_PWY3O-1801"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_edge-008_03a34d5d8bbd	gomodel:RXN-10664	RO:0002413	gomodel:RXN-10662	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1801		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_assertion"": ""The model asserts gomodel:RXN-10664 RO:0002413 gomodel:RXN-10662."", ""source_locator"": ""./YeastPathways_PWY3O-1801.json#/facts/7; endpoint types: /individuals/12/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-1801.json"", ""title"": ""GO-CAM palmitoleate biosynthesis model YeastPathways_PWY3O-1801"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_edge-010_63bb66c6a2ad	gomodel:RXN-10664	RO:0002233	gomodel:FERROCYTOCHROME-B5_RXN-10664	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1801		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_assertion"": ""The model asserts gomodel:RXN-10664 RO:0002233 gomodel:FERROCYTOCHROME-B5_RXN-10664."", ""source_locator"": ""./YeastPathways_PWY3O-1801.json#/facts/9; endpoint types: /individuals/12/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-1801.json"", ""title"": ""GO-CAM palmitoleate biosynthesis model YeastPathways_PWY3O-1801"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_edge-011_cf53ae9d8da9	gomodel:RXN-10664	RO:0002233	CHEBI:57379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1801		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_assertion"": ""The model asserts gomodel:RXN-10664 RO:0002233 gomodel:CHEBI_57379_RXN-10664."", ""source_locator"": ""./YeastPathways_PWY3O-1801.json#/facts/10; endpoint types: /individuals/12/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-1801.json"", ""title"": ""GO-CAM palmitoleate biosynthesis model YeastPathways_PWY3O-1801"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_edge-013_fc5f0bab87d8	gomodel:RXN-10662	RO:0002234	CHEBI:32372	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1801		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_assertion"": ""The model asserts gomodel:RXN-10662 RO:0002234 gomodel:CHEBI_32372_RXN-10662."", ""source_locator"": ""./YeastPathways_PWY3O-1801.json#/facts/12; endpoint types: /individuals/11/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-1801.json"", ""title"": ""GO-CAM palmitoleate biosynthesis model YeastPathways_PWY3O-1801"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_edge-014_4e234720f852	SGD:S000003023	pathwaymech:enables	gomodel:RXN-10664	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1801		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_assertion"": ""The model asserts gomodel:RXN-10664 RO:0002333 gomodel:YGL055W-MONOMER_RXN-10664_controller."", ""source_locator"": ""./YeastPathways_PWY3O-1801.json#/facts/13; endpoint types: /individuals/12/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-1801.json"", ""title"": ""GO-CAM palmitoleate biosynthesis model YeastPathways_PWY3O-1801"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_edge-015_39e6c58d81f4	gomodel:RXN-10664	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1801		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_assertion"": ""The model asserts gomodel:RXN-10664 RO:0002233 gomodel:CHEBI_15379_RXN-10664."", ""source_locator"": ""./YeastPathways_PWY3O-1801.json#/facts/14; endpoint types: /individuals/12/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-1801.json"", ""title"": ""GO-CAM palmitoleate biosynthesis model YeastPathways_PWY3O-1801"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_edge-016_1699636c8317	gomodel:RXN-10662	RO:0002233	CHEBI:61540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1801		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_assertion"": ""The model asserts gomodel:RXN-10662 RO:0002233 gomodel:CHEBI_61540_RXN-10664."", ""source_locator"": ""./YeastPathways_PWY3O-1801.json#/facts/15; endpoint types: /individuals/11/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-1801.json"", ""title"": ""GO-CAM palmitoleate biosynthesis model YeastPathways_PWY3O-1801"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_edge-017_14594281a64a	SGD:S000003780	pathwaymech:enables	gomodel:RXN-10662	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1801		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_assertion"": ""The model asserts gomodel:RXN-10662 RO:0002333 gomodel:YeastPathways_PWY3O-1801/6690711d00000541."", ""source_locator"": ""./YeastPathways_PWY3O-1801.json#/facts/16; endpoint types: /individuals/11/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-1801.json"", ""title"": ""GO-CAM palmitoleate biosynthesis model YeastPathways_PWY3O-1801"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_edge-018_c52cbb60de11	gomodel:RXN-10664	BFO:0000050	GO:0006636	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1801		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_assertion"": ""The model asserts gomodel:RXN-10664 BFO:0000050 gomodel:YeastPathways_PWY3O-1801/YeastPathways_PWY3O-1801."", ""source_locator"": ""./YeastPathways_PWY3O-1801.json#/facts/17; endpoint types: /individuals/12/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-1801.json"", ""title"": ""GO-CAM palmitoleate biosynthesis model YeastPathways_PWY3O-1801"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_edge-019_8783a0f3d674	gomodel:RXN-10664	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-1801		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_assertion"": ""The model asserts gomodel:RXN-10664 RO:0002233 gomodel:CHEBI_15378_RXN-10664."", ""source_locator"": ""./YeastPathways_PWY3O-1801.json#/facts/18; endpoint types: /individuals/12/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-1801"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-1801.json"", ""title"": ""GO-CAM palmitoleate biosynthesis model YeastPathways_PWY3O-1801"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_location-8c643760a52d_2e220f1e2087	SGD:S000003023	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P21147	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:26928762) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P21147"", ""source_assertion"": ""UniProtKB:P21147 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/539/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P21147"", ""source_assertion"": ""UniProtKB:P21147 has the exact SGD cross-reference SGD:S000003023."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/539/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P21147"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P21147 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_location-3677ecc5d882_1ef95ed4d49b	SGD:S000003780	RO:0001025	GO:0005777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41903	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10092594)	"[{""reference_id"": ""UniProtKB:P41903"", ""source_assertion"": ""UniProtKB:P41903 annotates location Peroxisome (SL-0204)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1826/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P41903"", ""source_assertion"": ""UniProtKB:P41903 has the exact SGD cross-reference SGD:S000003780."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1826/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P41903"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41903 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-1801_cofactor-896cc10c6831_f56e7fbbf041	SGD:S000003023	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P21147	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P13516) Expected to bind 2 Fe(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P13516)	"[{""reference_id"": ""UniProtKB:P21147"", ""source_assertion"": ""UniProtKB:P21147 annotates CHEBI:29033 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/539/comments/0/cofactors/0; /results/539/comments/0/note""}, {""reference_id"": ""UniProtKB:P21147"", ""source_assertion"": ""UniProtKB:P21147 has the exact SGD cross-reference SGD:S000003023."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/539/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P21147"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P21147 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-001_c43708f2d09a	CHEBI:58121	pathwaymech:consumes	RHEA:14659	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14659		"[{""reference_id"": ""RHEA:14659"", ""source_assertion"": ""Rhea lists CHEBI:58121 on the substrates side of RHEA:14659 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14659']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14659"", ""source_version"": ""139"", ""title"": ""RHEA:14659 authority record"", ""url"": ""https://www.rhea-db.org/rhea/14659""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-002_4f07bdec4961	RHEA:14659	pathwaymech:produces	CHEBI:58273	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14659		"[{""reference_id"": ""RHEA:14659"", ""source_assertion"": ""Rhea lists CHEBI:58273 on the products side of RHEA:14659 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14659']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14659"", ""source_version"": ""139"", ""title"": ""RHEA:14659 authority record"", ""url"": ""https://www.rhea-db.org/rhea/14659""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-003_006d256bc6ce	CHEBI:58121	pathwaymech:consumes	RHEA:13678	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13678		"[{""reference_id"": ""RHEA:13678"", ""source_assertion"": ""Rhea lists CHEBI:58121 on the substrates side of RHEA:13678 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13678']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13678"", ""source_version"": ""139"", ""title"": ""RHEA:13678 authority record"", ""url"": ""https://www.rhea-db.org/rhea/13678""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-004_7551147eaec8	RHEA:13678	pathwaymech:produces	CHEBI:57737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13678		"[{""reference_id"": ""RHEA:13678"", ""source_assertion"": ""Rhea lists CHEBI:57737 on the products side of RHEA:13678 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13678']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13678"", ""source_version"": ""139"", ""title"": ""RHEA:13678 authority record"", ""url"": ""https://www.rhea-db.org/rhea/13678""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-005_8b2bcf69f75e	CHEBI:57737	pathwaymech:consumes	RHEA:10510	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10510		"[{""reference_id"": ""RHEA:10510"", ""source_assertion"": ""Rhea lists CHEBI:57737 on the substrates side of RHEA:10510 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10510']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10510"", ""source_version"": ""139"", ""title"": ""RHEA:10510 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10510""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-006_81dc9a80d303	CHEBI:58273	pathwaymech:consumes	RHEA:10510	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10510		"[{""reference_id"": ""RHEA:10510"", ""source_assertion"": ""Rhea lists CHEBI:58273 on the substrates side of RHEA:10510 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10510']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10510"", ""source_version"": ""139"", ""title"": ""RHEA:10510 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10510""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-007_a76b7643584d	RHEA:10510	pathwaymech:produces	CHEBI:57483	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10510		"[{""reference_id"": ""RHEA:10510"", ""source_assertion"": ""Rhea lists CHEBI:57483 on the products side of RHEA:10510 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10510']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10510"", ""source_version"": ""139"", ""title"": ""RHEA:10510 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10510""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-008_cdf92aac9fe4	RHEA:10510	pathwaymech:produces	CHEBI:59776	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10510		"[{""reference_id"": ""RHEA:10510"", ""source_assertion"": ""Rhea lists CHEBI:59776 on the products side of RHEA:10510 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10510']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10510"", ""source_version"": ""139"", ""title"": ""RHEA:10510 authority record"", ""url"": ""https://www.rhea-db.org/rhea/10510""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-009_1773834795ce	CHEBI:57483	pathwaymech:consumes	RHEA:17054	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17054		"[{""reference_id"": ""RHEA:17054"", ""source_assertion"": ""Rhea lists CHEBI:57483 on the substrates side of RHEA:17054 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17054']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17054"", ""source_version"": ""139"", ""title"": ""RHEA:17054 authority record"", ""url"": ""https://www.rhea-db.org/rhea/17054""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-010_cf68c1912bf4	CHEBI:59776	pathwaymech:consumes	RHEA:17054	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17054		"[{""reference_id"": ""RHEA:17054"", ""source_assertion"": ""Rhea lists CHEBI:59776 on the substrates side of RHEA:17054 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17054']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17054"", ""source_version"": ""139"", ""title"": ""RHEA:17054 authority record"", ""url"": ""https://www.rhea-db.org/rhea/17054""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-011_bffefe38bcc5	RHEA:17054	pathwaymech:produces	CHEBI:16897	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17054		"[{""reference_id"": ""RHEA:17054"", ""source_assertion"": ""Rhea lists CHEBI:16897 on the products side of RHEA:17054 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17054']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17054"", ""source_version"": ""139"", ""title"": ""RHEA:17054 authority record"", ""url"": ""https://www.rhea-db.org/rhea/17054""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-012_30e527a91993	RHEA:17054	pathwaymech:produces	CHEBI:57634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17054		"[{""reference_id"": ""RHEA:17054"", ""source_assertion"": ""Rhea lists CHEBI:57634 on the products side of RHEA:17054 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/17054']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17054"", ""source_version"": ""139"", ""title"": ""RHEA:17054 authority record"", ""url"": ""https://www.rhea-db.org/rhea/17054""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-013_4090808f1fda	CHEBI:16897	pathwaymech:consumes	RHEA:27627	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27627		"[{""reference_id"": ""RHEA:27627"", ""source_assertion"": ""Rhea lists CHEBI:16897 on the substrates side of RHEA:27627 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27627']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27627"", ""source_version"": ""139"", ""title"": ""RHEA:27627 authority record"", ""url"": ""https://www.rhea-db.org/rhea/27627""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-014_a49a155a936f	CHEBI:57737	pathwaymech:consumes	RHEA:27627	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27627		"[{""reference_id"": ""RHEA:27627"", ""source_assertion"": ""Rhea lists CHEBI:57737 on the substrates side of RHEA:27627 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27627']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27627"", ""source_version"": ""139"", ""title"": ""RHEA:27627 authority record"", ""url"": ""https://www.rhea-db.org/rhea/27627""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-015_492fa15500be	RHEA:27627	pathwaymech:produces	CHEBI:57634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27627		"[{""reference_id"": ""RHEA:27627"", ""source_assertion"": ""Rhea lists CHEBI:57634 on the products side of RHEA:27627 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27627']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27627"", ""source_version"": ""139"", ""title"": ""RHEA:27627 authority record"", ""url"": ""https://www.rhea-db.org/rhea/27627""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-016_3c21bcc26f7c	RHEA:27627	pathwaymech:produces	CHEBI:59776	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27627		"[{""reference_id"": ""RHEA:27627"", ""source_assertion"": ""Rhea lists CHEBI:59776 on the products side of RHEA:27627 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27627']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27627"", ""source_version"": ""139"", ""title"": ""RHEA:27627 authority record"", ""url"": ""https://www.rhea-db.org/rhea/27627""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-017_097a0048e16b	EC:5.3.1.6	pathwaymech:catalyzes	RHEA:14659	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14657		"[{""reference_id"": ""RHEA:14657"", ""source_assertion"": ""Rhea associates EC:5.3.1.6 with the reaction family containing RHEA:14659."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:14657"", ""source_version"": ""139"", ""title"": ""Rhea ribose-5-phosphate isomerase reaction"", ""url"": ""https://www.rhea-db.org/rhea/14657""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-018_a5b9d44cac19	EC:5.1.3.1	pathwaymech:catalyzes	RHEA:13678	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13677		"[{""reference_id"": ""RHEA:13677"", ""source_assertion"": ""Rhea associates EC:5.1.3.1 with the reaction family containing RHEA:13678."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:13677"", ""source_version"": ""139"", ""title"": ""Rhea ribulose-phosphate 3-epimerase reaction"", ""url"": ""https://www.rhea-db.org/rhea/13677""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-019_2deb9fa7645f	EC:2.2.1.1	pathwaymech:catalyzes	RHEA:10510	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10508		"[{""reference_id"": ""RHEA:10508"", ""source_assertion"": ""Rhea associates EC:2.2.1.1 with the reaction family containing RHEA:10510."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:10508"", ""source_version"": ""139"", ""title"": ""Rhea transketolase sedoheptulose-7-phosphate reaction"", ""url"": ""https://www.rhea-db.org/rhea/10508""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-020_79793a24f1a0	EC:2.2.1.2	pathwaymech:catalyzes	RHEA:17054	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17053		"[{""reference_id"": ""RHEA:17053"", ""source_assertion"": ""Rhea associates EC:2.2.1.2 with the reaction family containing RHEA:17054."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:17053"", ""source_version"": ""139"", ""title"": ""Rhea transaldolase reaction"", ""url"": ""https://www.rhea-db.org/rhea/17053""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-021_e17f2eb6ce5b	EC:2.2.1.1	pathwaymech:catalyzes	RHEA:27627	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27626		"[{""reference_id"": ""RHEA:27626"", ""source_assertion"": ""Rhea associates EC:2.2.1.1 with the reaction family containing RHEA:27627."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:27626"", ""source_version"": ""139"", ""title"": ""Rhea transketolase fructose-6-phosphate reaction"", ""url"": ""https://www.rhea-db.org/rhea/27626""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-022_f8be9932d884	RHEA:10510	pathwaymech:precedes	RHEA:17054	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:NONOXIPENT-PWY		"[{""reference_id"": ""MetaCyc:NONOXIPENT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:10510 before RHEA:17054 in this pathway. Shared intermediate: CHEBI:57483, CHEBI:59776."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:NONOXIPENT-PWY"", ""source_sha256"": ""52ec2a5a95b9594522b084c16b3579a15d6e49512e6daed4e2e76627cf18b5d6"", ""source_version"": ""22.5"", ""title"": ""MetaCyc pentose phosphate pathway (non-oxidative branch) I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:NONOXIPENT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-023_d502dbf3ff88	RHEA:13678	pathwaymech:precedes	RHEA:10510	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:NONOXIPENT-PWY		"[{""reference_id"": ""MetaCyc:NONOXIPENT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:13678 before RHEA:10510 in this pathway. Shared intermediate: CHEBI:57737."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:NONOXIPENT-PWY"", ""source_sha256"": ""52ec2a5a95b9594522b084c16b3579a15d6e49512e6daed4e2e76627cf18b5d6"", ""source_version"": ""22.5"", ""title"": ""MetaCyc pentose phosphate pathway (non-oxidative branch) I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:NONOXIPENT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-024_e60614d9b2ae	RHEA:13678	pathwaymech:precedes	RHEA:27627	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:NONOXIPENT-PWY		"[{""reference_id"": ""MetaCyc:NONOXIPENT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:13678 before RHEA:27627 in this pathway. Shared intermediate: CHEBI:57737."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:NONOXIPENT-PWY"", ""source_sha256"": ""52ec2a5a95b9594522b084c16b3579a15d6e49512e6daed4e2e76627cf18b5d6"", ""source_version"": ""22.5"", ""title"": ""MetaCyc pentose phosphate pathway (non-oxidative branch) I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:NONOXIPENT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-025_bd86f515f747	RHEA:14659	pathwaymech:precedes	RHEA:10510	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:NONOXIPENT-PWY		"[{""reference_id"": ""MetaCyc:NONOXIPENT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:14659 before RHEA:10510 in this pathway. Shared intermediate: CHEBI:58273."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:NONOXIPENT-PWY"", ""source_sha256"": ""52ec2a5a95b9594522b084c16b3579a15d6e49512e6daed4e2e76627cf18b5d6"", ""source_version"": ""22.5"", ""title"": ""MetaCyc pentose phosphate pathway (non-oxidative branch) I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:NONOXIPENT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-026_998120209382	RHEA:17054	pathwaymech:precedes	RHEA:27627	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:NONOXIPENT-PWY		"[{""reference_id"": ""MetaCyc:NONOXIPENT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:17054 before RHEA:27627 in this pathway. Shared intermediate: CHEBI:16897."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:NONOXIPENT-PWY"", ""source_sha256"": ""52ec2a5a95b9594522b084c16b3579a15d6e49512e6daed4e2e76627cf18b5d6"", ""source_version"": ""22.5"", ""title"": ""MetaCyc pentose phosphate pathway (non-oxidative branch) I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:NONOXIPENT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-027_314174de3acc	UniProtKB:P0A7Z0	pathwaymech:enables	RHEA:14659	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A7Z0		"[{""reference_id"": ""UniProtKB:P0A7Z0"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A7Z0 with catalytic activity for the reaction family of RHEA:14659. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A7Z0"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A7Z0 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A7Z0.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-028_5db0c1b6ab38	UniProtKB:P0A867	pathwaymech:enables	RHEA:17054	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A867		"[{""reference_id"": ""UniProtKB:P0A867"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A867 with catalytic activity for the reaction family of RHEA:17054. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A867"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A867 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A867.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-029_a8cbb7424735	UniProtKB:P0A867	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A867		"[{""reference_id"": ""UniProtKB:P0A867"", ""source_assertion"": ""UniProt locates UniProtKB:P0A867 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A867"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A867 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A867.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-030_710214003177	UniProtKB:P0A870	pathwaymech:enables	RHEA:17054	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A870		"[{""reference_id"": ""UniProtKB:P0A870"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A870 with catalytic activity for the reaction family of RHEA:17054. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A870"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A870 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A870.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-031_a53f8f4abdbe	UniProtKB:P0A870	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A870		"[{""reference_id"": ""UniProtKB:P0A870"", ""source_assertion"": ""UniProt locates UniProtKB:P0A870 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A870"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A870 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A870.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-032_3c7924258c85	UniProtKB:P0AG07	pathwaymech:enables	RHEA:13678	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AG07		"[{""reference_id"": ""UniProtKB:P0AG07"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AG07 with catalytic activity for the reaction family of RHEA:13678. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AG07"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AG07 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AG07.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-033_23c55c5d7bb1	UniProtKB:P0AG07	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AG07		"[{""reference_id"": ""UniProtKB:P0AG07"", ""source_assertion"": ""UniProt lists CHEBI:48828 as a cofactor of UniProtKB:P0AG07 (evidence: ECO:0000269). Binds 1 divalent metal cation per subunit. Active with Co(2+), Fe(2+), Mn(2+) and Zn(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AG07"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AG07 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AG07.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-034_c50b69150572	UniProtKB:P0AG07	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AG07		"[{""reference_id"": ""UniProtKB:P0AG07"", ""source_assertion"": ""UniProt lists CHEBI:29033 as a cofactor of UniProtKB:P0AG07 (evidence: ECO:0000269). Binds 1 divalent metal cation per subunit. Active with Co(2+), Fe(2+), Mn(2+) and Zn(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AG07"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AG07 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AG07.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-035_cbf10ef5f07b	UniProtKB:P0AG07	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AG07		"[{""reference_id"": ""UniProtKB:P0AG07"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P0AG07 (evidence: ECO:0000269). Binds 1 divalent metal cation per subunit. Active with Co(2+), Fe(2+), Mn(2+) and Zn(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AG07"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AG07 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AG07.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-036_49a85235f0aa	UniProtKB:P0AG07	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AG07		"[{""reference_id"": ""UniProtKB:P0AG07"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P0AG07 (evidence: ECO:0000269). Binds 1 divalent metal cation per subunit. Active with Co(2+), Fe(2+), Mn(2+) and Zn(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AG07"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AG07 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AG07.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-037_ca1f3caa8364	UniProtKB:P27302	pathwaymech:enables	RHEA:10510	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P27302		"[{""reference_id"": ""UniProtKB:P27302"", ""source_assertion"": ""UniProt annotates UniProtKB:P27302 with catalytic activity for the reaction family of RHEA:10510. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P27302"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P27302 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P27302.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-038_fcae498c1df4	UniProtKB:P27302	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P27302		"[{""reference_id"": ""UniProtKB:P27302"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P27302 (evidence: ECO:0000269). Binds 1 Mg(2+) ion per subunit (PubMed:7607225, Ref.14). Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+) (PubMed:7607225)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P27302"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P27302 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P27302.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-039_b4d15e8ca50f	UniProtKB:P27302	pathwaymech:has_cofactor	CHEBI:29108	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P27302		"[{""reference_id"": ""UniProtKB:P27302"", ""source_assertion"": ""UniProt lists CHEBI:29108 as a cofactor of UniProtKB:P27302 (evidence: ECO:0000269). Binds 1 Mg(2+) ion per subunit (PubMed:7607225, Ref.14). Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+) (PubMed:7607225)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P27302"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P27302 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P27302.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-040_eed0aa736fb2	UniProtKB:P27302	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P27302		"[{""reference_id"": ""UniProtKB:P27302"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P27302 (evidence: ECO:0000269). Binds 1 Mg(2+) ion per subunit (PubMed:7607225, Ref.14). Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+) (PubMed:7607225)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P27302"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P27302 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P27302.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-041_cdcf14ddc1bd	UniProtKB:P27302	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P27302		"[{""reference_id"": ""UniProtKB:P27302"", ""source_assertion"": ""UniProt lists CHEBI:48828 as a cofactor of UniProtKB:P27302 (evidence: ECO:0000269). Binds 1 Mg(2+) ion per subunit (PubMed:7607225, Ref.14). Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+) (PubMed:7607225)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P27302"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P27302 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P27302.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-042_cf73bd36627c	UniProtKB:P27302	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P27302		"[{""reference_id"": ""UniProtKB:P27302"", ""source_assertion"": ""UniProt lists CHEBI:58937 as a cofactor of UniProtKB:P27302 (evidence: ECO:0000269). Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P27302"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P27302 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P27302.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-043_159300168807	UniProtKB:P33570	pathwaymech:enables	RHEA:10510	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33570		"[{""reference_id"": ""UniProtKB:P33570"", ""source_assertion"": ""UniProt annotates UniProtKB:P33570 with catalytic activity for the reaction family of RHEA:10510. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P33570"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P33570 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33570.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-044_09b2fa3dcb26	UniProtKB:P33570	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33570		"[{""reference_id"": ""UniProtKB:P33570"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P33570 (evidence: ECO:0000250). Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P33570"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P33570 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33570.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-045_5035c906615a	UniProtKB:P33570	pathwaymech:has_cofactor	CHEBI:29108	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33570		"[{""reference_id"": ""UniProtKB:P33570"", ""source_assertion"": ""UniProt lists CHEBI:29108 as a cofactor of UniProtKB:P33570 (evidence: ECO:0000250). Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P33570"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P33570 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33570.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-046_5608684fe911	UniProtKB:P33570	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33570		"[{""reference_id"": ""UniProtKB:P33570"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P33570 (evidence: ECO:0000250). Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P33570"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P33570 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33570.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-047_022f2fcf7bf2	UniProtKB:P33570	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33570		"[{""reference_id"": ""UniProtKB:P33570"", ""source_assertion"": ""UniProt lists CHEBI:48828 as a cofactor of UniProtKB:P33570 (evidence: ECO:0000250). Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P33570"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P33570 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33570.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-048_c6698e477d94	UniProtKB:P33570	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33570		"[{""reference_id"": ""UniProtKB:P33570"", ""source_assertion"": ""UniProt lists CHEBI:58937 as a cofactor of UniProtKB:P33570 (evidence: ECO:0000250). Binds 1 thiamine pyrophosphate per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P33570"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P33570 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33570.json""}]"	""
pathwaymech:MetaCyc_NONOXIPENT-PWY_edge-049_0f092aedb35b	UniProtKB:P37351	pathwaymech:enables	RHEA:14659	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37351		"[{""reference_id"": ""UniProtKB:P37351"", ""source_assertion"": ""UniProt annotates UniProtKB:P37351 with catalytic activity for the reaction family of RHEA:14659. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P37351"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P37351 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37351.json""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-001_50a5b3cc43ee	CHEBI:58349	pathwaymech:consumes	RHEA:15842	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15842		"[{""reference_id"": ""RHEA:15842"", ""source_assertion"": ""Rhea lists CHEBI:58349 on the substrates side of RHEA:15842 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15842']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15842"", ""source_version"": ""139"", ""title"": ""Rhea 6-phospho-D-glucono-1,5-lactone-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15842""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-002_a18a9f9fe22d	CHEBI:61548	pathwaymech:consumes	RHEA:15842	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15842		"[{""reference_id"": ""RHEA:15842"", ""source_assertion"": ""Rhea lists CHEBI:61548 on the substrates side of RHEA:15842 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15842']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15842"", ""source_version"": ""139"", ""title"": ""Rhea 6-phospho-D-glucono-1,5-lactone-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15842""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-003_a4e421ed0dec	RHEA:15842	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15842		"[{""reference_id"": ""RHEA:15842"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:15842 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15842']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15842"", ""source_version"": ""139"", ""title"": ""Rhea 6-phospho-D-glucono-1,5-lactone-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15842""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-004_c789122f97f6	RHEA:15842	pathwaymech:produces	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15842		"[{""reference_id"": ""RHEA:15842"", ""source_assertion"": ""Rhea lists CHEBI:57783 on the products side of RHEA:15842 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15842']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15842"", ""source_version"": ""139"", ""title"": ""Rhea 6-phospho-D-glucono-1,5-lactone-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15842""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-005_61884ebf693a	RHEA:15842	pathwaymech:produces	CHEBI:57955	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15842		"[{""reference_id"": ""RHEA:15842"", ""source_assertion"": ""Rhea lists CHEBI:57955 on the products side of RHEA:15842 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15842']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15842"", ""source_version"": ""139"", ""title"": ""Rhea 6-phospho-D-glucono-1,5-lactone-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15842""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-006_26ea3764d96e	CHEBI:15377	pathwaymech:consumes	RHEA:12557	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12557		"[{""reference_id"": ""RHEA:12557"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:12557 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12557']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12557"", ""source_version"": ""139"", ""title"": ""Rhea 6-phospho-D-gluconate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12557""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-007_7aa4011173bf	CHEBI:57955	pathwaymech:consumes	RHEA:12557	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12557		"[{""reference_id"": ""RHEA:12557"", ""source_assertion"": ""Rhea lists CHEBI:57955 on the substrates side of RHEA:12557 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12557']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12557"", ""source_version"": ""139"", ""title"": ""Rhea 6-phospho-D-gluconate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12557""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-008_a5a0ada57f93	RHEA:12557	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12557		"[{""reference_id"": ""RHEA:12557"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:12557 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12557']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12557"", ""source_version"": ""139"", ""title"": ""Rhea 6-phospho-D-gluconate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12557""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-009_401923ca9285	RHEA:12557	pathwaymech:produces	CHEBI:58759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12557		"[{""reference_id"": ""RHEA:12557"", ""source_assertion"": ""Rhea lists CHEBI:58759 on the products side of RHEA:12557 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12557']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12557"", ""source_version"": ""139"", ""title"": ""Rhea 6-phospho-D-gluconate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12557""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-010_e264cace4e1f	CHEBI:58349	pathwaymech:consumes	RHEA:10117	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10117		"[{""reference_id"": ""RHEA:10117"", ""source_assertion"": ""Rhea lists CHEBI:58349 on the substrates side of RHEA:10117 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10117']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10117"", ""source_version"": ""139"", ""title"": ""Rhea D-ribulose 5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10117""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-011_53d8652f2a64	CHEBI:58759	pathwaymech:consumes	RHEA:10117	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10117		"[{""reference_id"": ""RHEA:10117"", ""source_assertion"": ""Rhea lists CHEBI:58759 on the substrates side of RHEA:10117 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10117']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10117"", ""source_version"": ""139"", ""title"": ""Rhea D-ribulose 5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10117""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-012_cfe8fc5ddaaf	RHEA:10117	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10117		"[{""reference_id"": ""RHEA:10117"", ""source_assertion"": ""Rhea lists CHEBI:16526 on the products side of RHEA:10117 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10117']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10117"", ""source_version"": ""139"", ""title"": ""Rhea D-ribulose 5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10117""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-013_5c8e245ee11b	RHEA:10117	pathwaymech:produces	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10117		"[{""reference_id"": ""RHEA:10117"", ""source_assertion"": ""Rhea lists CHEBI:57783 on the products side of RHEA:10117 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10117']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10117"", ""source_version"": ""139"", ""title"": ""Rhea D-ribulose 5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10117""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-014_70f0bcf4b4b2	RHEA:10117	pathwaymech:produces	CHEBI:58121	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10117		"[{""reference_id"": ""RHEA:10117"", ""source_assertion"": ""Rhea lists CHEBI:58121 on the products side of RHEA:10117 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10117']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10117"", ""source_version"": ""139"", ""title"": ""Rhea D-ribulose 5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10117""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-015_a0e19202c5dd	EC:1.1.1.49	pathwaymech:catalyzes	RHEA:15842	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15841		"[{""reference_id"": ""RHEA:15841"", ""source_assertion"": ""Rhea associates EC:1.1.1.49 with the reaction family containing RHEA:15842."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:15841"", ""source_version"": ""139"", ""title"": ""Rhea glucose-6-phosphate dehydrogenase reaction"", ""url"": ""https://www.rhea-db.org/rhea/15841""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-016_9109fa6b5a5e	EC:3.1.1.31	pathwaymech:catalyzes	RHEA:12557	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12556		"[{""reference_id"": ""RHEA:12556"", ""source_assertion"": ""Rhea associates EC:3.1.1.31 with the reaction family containing RHEA:12557."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:12556"", ""source_version"": ""139"", ""title"": ""Rhea 6-phosphogluconolactonase reaction"", ""url"": ""https://www.rhea-db.org/rhea/12556""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-017_8158cff7b416	EC:1.1.1.44	pathwaymech:catalyzes	RHEA:10117	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10116		"[{""reference_id"": ""RHEA:10116"", ""source_assertion"": ""Rhea associates EC:1.1.1.44 with the reaction family containing RHEA:10117."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:10116"", ""source_version"": ""139"", ""title"": ""Rhea 6-phosphogluconate dehydrogenase reaction"", ""url"": ""https://www.rhea-db.org/rhea/10116""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-018_4dc2c2512454	RHEA:12557	pathwaymech:precedes	RHEA:10117	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:OXIDATIVEPENT-PWY		"[{""reference_id"": ""MetaCyc:OXIDATIVEPENT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:12557 before RHEA:10117 in this pathway. Shared intermediate: CHEBI:58759."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:OXIDATIVEPENT-PWY"", ""source_sha256"": ""716f68f1713011024b6998d8d9c15d69c3d293ef4c3c9e0bb4cbae2dac003fb8"", ""source_version"": ""22.5"", ""title"": ""MetaCyc pentose phosphate pathway (oxidative branch) I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:OXIDATIVEPENT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-019_ead8c9934fd1	RHEA:15842	pathwaymech:precedes	RHEA:12557	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:OXIDATIVEPENT-PWY		"[{""reference_id"": ""MetaCyc:OXIDATIVEPENT-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:15842 before RHEA:12557 in this pathway. Shared intermediate: CHEBI:57955."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:OXIDATIVEPENT-PWY"", ""source_sha256"": ""716f68f1713011024b6998d8d9c15d69c3d293ef4c3c9e0bb4cbae2dac003fb8"", ""source_version"": ""22.5"", ""title"": ""MetaCyc pentose phosphate pathway (oxidative branch) I"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:OXIDATIVEPENT-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-020_f7ad8737f384	UniProtKB:P00350	pathwaymech:enables	RHEA:10117	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00350		"[{""reference_id"": ""UniProtKB:P00350"", ""source_assertion"": ""UniProt annotates UniProtKB:P00350 with catalytic activity for the reaction family of RHEA:10117. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00350"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00350 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00350.json""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-021_dbf009ddd61e	UniProtKB:P0AC53	pathwaymech:enables	RHEA:15842	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AC53		"[{""reference_id"": ""UniProtKB:P0AC53"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AC53 with catalytic activity for the reaction family of RHEA:15842. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AC53"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AC53 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AC53.json""}]"	""
pathwaymech:MetaCyc_OXIDATIVEPENT-PWY_edge-022_860d5ca12263	UniProtKB:P52697	pathwaymech:enables	RHEA:12557	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P52697		"[{""reference_id"": ""UniProtKB:P52697"", ""source_assertion"": ""UniProt annotates UniProtKB:P52697 with catalytic activity for the reaction family of RHEA:12557. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P52697"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P52697 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P52697.json""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-1_edc5eccfab39	CHEBI:20995	pathwaymech:consumes	WikiPathways:WP5060/ac9d2	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML ac9d2 connects normalized CHEBI:20995 as an input of interaction ac9d2."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ac9d2']/Graphics; /Pathway/DataNode[@GraphId='a5f2a']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-2_a2dd87d1020e	WikiPathways:WP5060/ac9d2	pathwaymech:produces	CHEBI:15946	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML ac9d2 connects normalized CHEBI:15946 as an output of interaction ac9d2."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ac9d2']/Graphics; /Pathway/DataNode[@GraphId='e83ae']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-3_d11f3e6bac38	CHEBI:18199	pathwaymech:consumes	WikiPathways:WP5060/adda4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML adda4 connects normalized CHEBI:18199 as an input of interaction adda4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='adda4']/Graphics; /Pathway/DataNode[@GraphId='e7be7']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-4_7e085e98f4f3	WikiPathways:WP5060/adda4	pathwaymech:produces	CHEBI:61543	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML adda4 connects normalized CHEBI:61543 as an output of interaction adda4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='adda4']/Graphics; /Pathway/DataNode[@GraphId='b5141']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-5_e0fca110a508	CHEBI:15946	pathwaymech:consumes	WikiPathways:WP5060/af0e7	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML af0e7 connects normalized CHEBI:15946 as an input of interaction af0e7."", ""source_locator"": ""/Pathway/Interaction[@GraphId='af0e7']/Graphics; /Pathway/DataNode[@GraphId='e83ae']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-6_6997be54b271	WikiPathways:WP5060/af0e7	pathwaymech:produces	CHEBI:20995	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML af0e7 connects normalized CHEBI:20995 as an output of interaction af0e7."", ""source_locator"": ""/Pathway/Interaction[@GraphId='af0e7']/Graphics; /Pathway/DataNode[@GraphId='a5f2a']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-7_4953f9130e91	CHEBI:40666	pathwaymech:consumes	WikiPathways:WP5060/af315	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML af315 connects normalized CHEBI:40666 as an input of interaction af315."", ""source_locator"": ""/Pathway/Interaction[@GraphId='af315']/Graphics; /Pathway/DataNode[@GraphId='a8855']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-8_dbfb42287808	WikiPathways:WP5060/af315	pathwaymech:produces	CHEBI:47968	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML af315 connects normalized CHEBI:47968 as an output of interaction af315."", ""source_locator"": ""/Pathway/Interaction[@GraphId='af315']/Graphics; /Pathway/DataNode[@GraphId='f14a1']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-9_ce9c5daf7409	WikiPathways:WP5060/de8b0	pathwaymech:consumes	WikiPathways:WP5060/b423c	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML b423c connects normalized WikiPathways:WP5060/de8b0 as an input of interaction b423c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='b423c']/Graphics; /Pathway/DataNode[@GraphId='de8b0']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-10_be42424c9186	WikiPathways:WP5060/b423c	pathwaymech:produces	CHEBI:61564	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML b423c connects normalized CHEBI:61564 as an output of interaction b423c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='b423c']/Graphics; /Pathway/DataNode[@GraphId='ed65e']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-11_c33e1ddeeffe	WikiPathways:WP5060/e9564	pathwaymech:consumes	WikiPathways:WP5060/b5af5	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML b5af5 connects normalized WikiPathways:WP5060/e9564 as an input of interaction b5af5."", ""source_locator"": ""/Pathway/Interaction[@GraphId='b5af5']/Graphics; /Pathway/DataNode[@GraphId='e9564']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-12_599620a54d3d	WikiPathways:WP5060/b5af5	pathwaymech:produces	WikiPathways:WP5060/e9564	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML b5af5 connects normalized WikiPathways:WP5060/e9564 as an output of interaction b5af5."", ""source_locator"": ""/Pathway/Interaction[@GraphId='b5af5']/Graphics; /Pathway/DataNode[@GraphId='c345c']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-13_bb6e0208594e	CHEBI:28639	pathwaymech:consumes	WikiPathways:WP5060/b8180	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML b8180 connects normalized CHEBI:28639 as an input of interaction b8180."", ""source_locator"": ""/Pathway/Interaction[@GraphId='b8180']/Graphics; /Pathway/DataNode[@GraphId='c0dd7']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-14_091601ec45ed	WikiPathways:WP5060/b8180	pathwaymech:produces	CHEBI:18199	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML b8180 connects normalized CHEBI:18199 as an output of interaction b8180."", ""source_locator"": ""/Pathway/Interaction[@GraphId='b8180']/Graphics; /Pathway/DataNode[@GraphId='e7be7']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-15_70edc5c7cdc7	CHEBI:68483	pathwaymech:consumes	WikiPathways:WP5060/b8d40	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML b8d40 connects normalized CHEBI:68483 as an input of interaction b8d40."", ""source_locator"": ""/Pathway/Interaction[@GraphId='b8d40']/Graphics; /Pathway/DataNode[@GraphId='c4246']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-16_0fe89861fa6f	WikiPathways:WP5060/b8d40	pathwaymech:produces	CHEBI:70765	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML b8d40 connects normalized CHEBI:70765 as an output of interaction b8d40."", ""source_locator"": ""/Pathway/Interaction[@GraphId='b8d40']/Graphics; /Pathway/DataNode[@GraphId='db31c']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-17_b174e231c38d	CHEBI:174383	pathwaymech:consumes	WikiPathways:WP5060/bcf55	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML bcf55 connects normalized CHEBI:174383 as an input of interaction bcf55."", ""source_locator"": ""/Pathway/Interaction[@GraphId='bcf55']/Graphics; /Pathway/DataNode[@GraphId='e2e4d']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-18_8e49b0a54bc9	WikiPathways:WP5060/bcf55	pathwaymech:produces	CHEBI:16446	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML bcf55 connects normalized CHEBI:16446 as an output of interaction bcf55."", ""source_locator"": ""/Pathway/Interaction[@GraphId='bcf55']/Graphics; /Pathway/DataNode[@GraphId='e0ff9']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-19_4e3feb347f6f	CHEBI:506227	pathwaymech:consumes	WikiPathways:WP5060/c0f79	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML c0f79 connects normalized CHEBI:506227 as an input of interaction c0f79."", ""source_locator"": ""/Pathway/Interaction[@GraphId='c0f79']/Graphics; /Pathway/DataNode[@GraphId='c45e3']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-20_372b93223331	WikiPathways:WP5060/c0f79	pathwaymech:produces	CHEBI:15784	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML c0f79 connects normalized CHEBI:15784 as an output of interaction c0f79."", ""source_locator"": ""/Pathway/Interaction[@GraphId='c0f79']/Graphics; /Pathway/DataNode[@GraphId='b0b99']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-21_c367dee613db	CHEBI:15784	pathwaymech:consumes	WikiPathways:WP5060/c131c	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML c131c connects normalized CHEBI:15784 as an input of interaction c131c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='c131c']/Graphics; /Pathway/DataNode[@GraphId='b0b99']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-22_17b010d16b25	WikiPathways:WP5060/c131c	pathwaymech:produces	CHEBI:20995	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML c131c connects normalized CHEBI:20995 as an output of interaction c131c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='c131c']/Graphics; /Pathway/DataNode[@GraphId='a5f2a']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-23_30c59b8f296c	CHEBI:15570	pathwaymech:consumes	WikiPathways:WP5060/cdc0a	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML cdc0a connects normalized CHEBI:15570 as an input of interaction cdc0a."", ""source_locator"": ""/Pathway/Interaction[@GraphId='cdc0a']/Graphics; /Pathway/DataNode[@GraphId='ce380']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-24_3461240d54cd	WikiPathways:WP5060/cdc0a	pathwaymech:produces	CHEBI:16576	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML cdc0a connects normalized CHEBI:16576 as an output of interaction cdc0a."", ""source_locator"": ""/Pathway/Interaction[@GraphId='cdc0a']/Graphics; /Pathway/DataNode[@GraphId='abc1f']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-25_92ee7624c895	CHEBI:70765	pathwaymech:consumes	WikiPathways:WP5060/d013c	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML d013c connects normalized CHEBI:70765 as an input of interaction d013c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='d013c']/Graphics; /Pathway/DataNode[@GraphId='db31c']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-26_23559fe924c4	WikiPathways:WP5060/d013c	pathwaymech:produces	CHEBI:16932	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML d013c connects normalized CHEBI:16932 as an output of interaction d013c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='d013c']/Graphics; /Pathway/DataNode[@GraphId='a6683']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-27_d20c27184bcd	CHEBI:29985	pathwaymech:consumes	WikiPathways:WP5060/d5182	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060	The source has arrowheads on both endpoints; the displayed orientation is one direction of a reversible conversion.	"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML d5182 connects normalized CHEBI:29985 as an input of interaction d5182."", ""source_locator"": ""/Pathway/Interaction[@GraphId='d5182']/Graphics; /Pathway/DataNode[@GraphId='ff05c']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-28_14527412d137	WikiPathways:WP5060/d5182	pathwaymech:produces	CHEBI:29986	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060	The source has arrowheads on both endpoints; the displayed orientation is one direction of a reversible conversion.	"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML d5182 connects normalized CHEBI:29986 as an output of interaction d5182."", ""source_locator"": ""/Pathway/Interaction[@GraphId='d5182']/Graphics; /Pathway/DataNode[@GraphId='b18c7']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-29_9d7785d2f74d	CHEBI:28138	pathwaymech:consumes	WikiPathways:WP5060/d89b1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML d89b1 connects normalized CHEBI:28138 as an input of interaction d89b1."", ""source_locator"": ""/Pathway/Interaction[@GraphId='d89b1']/Graphics; /Pathway/DataNode[@GraphId='d1db8']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-30_c71c8120465b	WikiPathways:WP5060/d89b1	pathwaymech:produces	CHEBI:8005	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML d89b1 connects normalized CHEBI:8005 as an output of interaction d89b1."", ""source_locator"": ""/Pathway/Interaction[@GraphId='d89b1']/Graphics; /Pathway/DataNode[@GraphId='b806f']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-31_548ffeaff175	CHEBI:16264	pathwaymech:consumes	WikiPathways:WP5060/e2f23	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML e2f23 connects normalized CHEBI:16264 as an input of interaction e2f23."", ""source_locator"": ""/Pathway/Interaction[@GraphId='e2f23']/Graphics; /Pathway/DataNode[@GraphId='b6d47']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-32_1e54d45e61ae	WikiPathways:WP5060/e2f23	pathwaymech:produces	CHEBI:68483	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML e2f23 connects normalized CHEBI:68483 as an output of interaction e2f23."", ""source_locator"": ""/Pathway/Interaction[@GraphId='e2f23']/Graphics; /Pathway/DataNode[@GraphId='c4246']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-33_e4e4f277e693	CHEBI:61564	pathwaymech:consumes	WikiPathways:WP5060/e8b23	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML e8b23 connects normalized CHEBI:61564 as an input of interaction e8b23."", ""source_locator"": ""/Pathway/Interaction[@GraphId='e8b23']/Graphics; /Pathway/DataNode[@GraphId='ed65e']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-34_abab453b8ea7	WikiPathways:WP5060/e8b23	pathwaymech:produces	CHEBI:28639	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML e8b23 connects normalized CHEBI:28639 as an output of interaction e8b23."", ""source_locator"": ""/Pathway/Interaction[@GraphId='e8b23']/Graphics; /Pathway/DataNode[@GraphId='c0dd7']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-35_f7fe5fb4570d	CHEBI:47965	pathwaymech:consumes	WikiPathways:WP5060/eab24	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML eab24 connects normalized CHEBI:47965 as an input of interaction eab24."", ""source_locator"": ""/Pathway/Interaction[@GraphId='eab24']/Graphics; /Pathway/DataNode[@GraphId='a0d71']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-36_9e521e34f1f4	WikiPathways:WP5060/eab24	pathwaymech:produces	CHEBI:47968	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML eab24 connects normalized CHEBI:47968 as an output of interaction eab24."", ""source_locator"": ""/Pathway/Interaction[@GraphId='eab24']/Graphics; /Pathway/DataNode[@GraphId='f14a1']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-37_f19a6e26aa60	CHEBI:16932	pathwaymech:consumes	WikiPathways:WP5060/eb85c	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML eb85c connects normalized CHEBI:16932 as an input of interaction eb85c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='eb85c']/Graphics; /Pathway/DataNode[@GraphId='a6683']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-38_2bdde36a7e60	WikiPathways:WP5060/eb85c	pathwaymech:produces	CHEBI:16970	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML eb85c connects normalized CHEBI:16970 as an output of interaction eb85c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='eb85c']/Graphics; /Pathway/DataNode[@GraphId='b2fd6']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-39_f616b06ae2f5	CHEBI:20995	pathwaymech:consumes	WikiPathways:WP5060/ebc50	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060	The source has arrowheads on both endpoints; the displayed orientation is one direction of a reversible conversion.	"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML ebc50 connects normalized CHEBI:20995 as an input of interaction ebc50."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ebc50']/Graphics; /Pathway/DataNode[@GraphId='a5f2a']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-40_f815db90aa5c	WikiPathways:WP5060/ebc50	pathwaymech:produces	CHEBI:174383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060	The source has arrowheads on both endpoints; the displayed orientation is one direction of a reversible conversion.	"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML ebc50 connects normalized CHEBI:174383 as an output of interaction ebc50."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ebc50']/Graphics; /Pathway/DataNode[@GraphId='e2e4d']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-41_aca162a91c0b	CHEBI:16970	pathwaymech:consumes	WikiPathways:WP5060/eff80	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML eff80 connects normalized CHEBI:16970 as an input of interaction eff80."", ""source_locator"": ""/Pathway/Interaction[@GraphId='eff80']/Graphics; /Pathway/DataNode[@GraphId='b2fd6']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-42_89ad763994be	WikiPathways:WP5060/eff80	pathwaymech:produces	CHEBI:28639	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML eff80 connects normalized CHEBI:28639 as an output of interaction eff80."", ""source_locator"": ""/Pathway/Interaction[@GraphId='eff80']/Graphics; /Pathway/DataNode[@GraphId='c0dd7']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-43_bf995b3dfef7	CHEBI:8005	pathwaymech:consumes	WikiPathways:WP5060/f4fde	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML f4fde connects normalized CHEBI:8005 as an input of interaction f4fde."", ""source_locator"": ""/Pathway/Interaction[@GraphId='f4fde']/Graphics; /Pathway/DataNode[@GraphId='b806f']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-44_4a6f6acbc101	WikiPathways:WP5060/f4fde	pathwaymech:produces	WikiPathways:WP5060/e9564	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML f4fde connects normalized WikiPathways:WP5060/e9564 as an output of interaction f4fde."", ""source_locator"": ""/Pathway/Interaction[@GraphId='f4fde']/Graphics; /Pathway/DataNode[@GraphId='e9564']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-45_66db9e83eebe	CHEBI:61543	pathwaymech:consumes	WikiPathways:WP5060/f53c7	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML f53c7 connects normalized CHEBI:61543 as an input of interaction f53c7."", ""source_locator"": ""/Pathway/Interaction[@GraphId='f53c7']/Graphics; /Pathway/DataNode[@GraphId='b5141']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-46_c09a84e972ec	WikiPathways:WP5060/f53c7	pathwaymech:produces	CHEBI:28138	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML f53c7 connects normalized CHEBI:28138 as an output of interaction f53c7."", ""source_locator"": ""/Pathway/Interaction[@GraphId='f53c7']/Graphics; /Pathway/DataNode[@GraphId='d1db8']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-47_04931c13e659	CHEBI:16446	pathwaymech:consumes	WikiPathways:WP5060/f628a	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML f628a connects normalized CHEBI:16446 as an input of interaction f628a."", ""source_locator"": ""/Pathway/Interaction[@GraphId='f628a']/Graphics; /Pathway/DataNode[@GraphId='e0ff9']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-48_dc276ff47311	WikiPathways:WP5060/f628a	pathwaymech:produces	CHEBI:16264	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML f628a connects normalized CHEBI:16264 as an output of interaction f628a."", ""source_locator"": ""/Pathway/Interaction[@GraphId='f628a']/Graphics; /Pathway/DataNode[@GraphId='b6d47']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-49_3cee3978e099	CHEBI:17047	pathwaymech:consumes	WikiPathways:WP5060/fb09e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML fb09e connects normalized CHEBI:17047 as an input of interaction fb09e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='fb09e']/Graphics; /Pathway/DataNode[@GraphId='ebd59']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-50_7b6852dd2d4f	WikiPathways:WP5060/fb09e	pathwaymech:produces	CHEBI:16141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML fb09e connects normalized CHEBI:16141 as an output of interaction fb09e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='fb09e']/Graphics; /Pathway/DataNode[@GraphId='fb1b0']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-51_b69d92a69c57	WikiPathways:WP5060/e9564	pathwaymech:consumes	WikiPathways:WP5060/ffa50	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML ffa50 connects normalized WikiPathways:WP5060/e9564 as an input of interaction ffa50."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ffa50']/Graphics; /Pathway/DataNode[@GraphId='c345c']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-52_c722500be97a	WikiPathways:WP5060/ffa50	pathwaymech:produces	WikiPathways:WP5060/a45c7	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML ffa50 connects normalized WikiPathways:WP5060/a45c7 as an output of interaction ffa50."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ffa50']/Graphics; /Pathway/DataNode[@GraphId='a45c7']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-53_8652698fd430	CHEBI:16977	pathwaymech:consumes	WikiPathways:WP5060/id535c37a4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060	The source has arrowheads on both endpoints; the displayed orientation is one direction of a reversible conversion.	"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML id535c37a4 connects normalized CHEBI:16977 as an input of interaction id535c37a4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id535c37a4']/Graphics; /Pathway/DataNode[@GraphId='eb48f']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-54_70a161c338b1	WikiPathways:WP5060/id535c37a4	pathwaymech:produces	CHEBI:15570	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060	The source has arrowheads on both endpoints; the displayed orientation is one direction of a reversible conversion.	"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML id535c37a4 connects normalized CHEBI:15570 as an output of interaction id535c37a4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id535c37a4']/Graphics; /Pathway/DataNode[@GraphId='ce380']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-55_a0240e515a8d	WikiPathways:WP5060/a45c7	pathwaymech:consumes	WikiPathways:WP5060/id92720196	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML id92720196 connects normalized WikiPathways:WP5060/a45c7 as an input of interaction id92720196."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id92720196']/Graphics; /Pathway/DataNode[@GraphId='a45c7']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-56_4780c8e031a0	WikiPathways:WP5060/id92720196	pathwaymech:produces	CHEBI:40666	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML id92720196 connects normalized CHEBI:40666 as an output of interaction id92720196."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id92720196']/Graphics; /Pathway/DataNode[@GraphId='a8855']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-57_497d1531f461	CHEBI:47968	pathwaymech:consumes	WikiPathways:WP5060/idb435b98e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML idb435b98e connects normalized CHEBI:47968 as an input of interaction idb435b98e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idb435b98e']/Graphics; /Pathway/DataNode[@GraphId='f14a1']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-58_7d4a1b7a9d88	WikiPathways:WP5060/idb435b98e	pathwaymech:produces	CHEBI:15784	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML idb435b98e connects normalized CHEBI:15784 as an output of interaction idb435b98e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idb435b98e']/Graphics; /Pathway/DataNode[@GraphId='b0b99']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-59_07ba53688ab1	UniProtKB:P76008	pathwaymech:catalyzes	WikiPathways:WP5060/b423c	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML id366132eb connects normalized UniProtKB:P76008 as a catalyst of interaction b423c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id366132eb']/Graphics; /Pathway/DataNode[@GraphId='fe081']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-60_b46bf415da99	UniProtKB:P0A6B4	pathwaymech:catalyzes	WikiPathways:WP5060/id535c37a4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML id486e1789 connects normalized UniProtKB:P0A6B4 as a catalyst of interaction id535c37a4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id486e1789']/Graphics; /Pathway/DataNode[@GraphId='f66da']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-61_3ff2d25134fd	UniProtKB:P75949	pathwaymech:catalyzes	WikiPathways:WP5060/ffa50	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML id5e9b20de connects normalized UniProtKB:P75949 as a catalyst of interaction ffa50."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5e9b20de']/Graphics; /Pathway/DataNode[@GraphId='a415b']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-62_d3ed263a7405	WikiPathways:WP5060/id92720196	pathwaymech:produces	WikiPathways:WP5060/de8b0	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML id61d3aad3 connects normalized WikiPathways:WP5060/de8b0 as an output of interaction id92720196."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id61d3aad3']/Graphics; /Pathway/DataNode[@GraphId='de8b0']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-63_029e86c80dfb	UniProtKB:P13016	pathwaymech:catalyzes	WikiPathways:WP5060/id92720196	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML id62b52135 connects normalized UniProtKB:P13016 as a catalyst of interaction id92720196."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id62b52135']/Graphics; /Pathway/DataNode[@GraphId='d25a8']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-64_d4bae0ea8d52	UniProtKB:Q2TL65	pathwaymech:catalyzes	WikiPathways:WP5060/d89b1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML id95f5144b connects normalized UniProtKB:Q2TL65 as a catalyst of interaction d89b1."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id95f5144b']/Graphics; /Pathway/DataNode[@GraphId='cce2b']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-65_1332f0a0bd04	CHEBI:70765	pathwaymech:consumes	WikiPathways:WP5060/e8b23	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML idb83aac52 connects normalized CHEBI:70765 as an input of interaction e8b23."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idb83aac52']/Graphics; /Pathway/DataNode[@GraphId='db31c']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-66_c43f75f7bd43	CHEBI:28300	pathwaymech:consumes	WikiPathways:WP5060/af0e7	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML idc67f0bc2 connects normalized CHEBI:28300 as an input of interaction af0e7."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idc67f0bc2']/Graphics; /Pathway/DataNode[@GraphId='d4cbd']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-67_ac941f0cf4d5	WikiPathways:WP5060/ffa50	pathwaymech:produces	CHEBI:506227	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML idcd2e130d connects normalized CHEBI:506227 as an output of interaction ffa50."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idcd2e130d']/Graphics; /Pathway/DataNode[@GraphId='c45e3']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-68_7cca23f64b0d	UniProtKB:P0AD68	pathwaymech:catalyzes	WikiPathways:WP5060/d89b1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML iddc402d25 connects normalized UniProtKB:P0AD68 as a catalyst of interaction d89b1."", ""source_locator"": ""/Pathway/Interaction[@GraphId='iddc402d25']/Graphics; /Pathway/DataNode[@GraphId='d937f']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-69_e22b78790d5b	UniProtKB:P17169	pathwaymech:catalyzes	WikiPathways:WP5060/af0e7	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML a73c0 connects normalized UniProtKB:P17169 as a catalyst of interaction af0e7."", ""source_locator"": ""/Pathway/Interaction[@GraphId='a73c0']/Graphics; /Pathway/DataNode[@GraphId='abfd4']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-70_ab613eda9c4e	UniProtKB:P0A6W3	pathwaymech:catalyzes	WikiPathways:WP5060/adda4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML e5322 connects normalized UniProtKB:P0A6W3 as a catalyst of interaction adda4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='e5322']/Graphics; /Pathway/DataNode[@GraphId='a7bb4']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-71_2a9418b225f8	CHEBI:46398	pathwaymech:consumes	WikiPathways:WP5060/f628a	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML e8fbc connects normalized CHEBI:46398 as an input of interaction f628a."", ""source_locator"": ""/Pathway/Interaction[@GraphId='e8fbc']/Graphics; /Pathway/DataNode[@GraphId='b9b67']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-72_791b650c4872	CHEBI:16488	pathwaymech:consumes	WikiPathways:WP5060/eff80	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML eac8f connects normalized CHEBI:16488 as an input of interaction eff80."", ""source_locator"": ""/Pathway/Interaction[@GraphId='eac8f']/Graphics; /Pathway/DataNode[@GraphId='eb5c4']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-73_22be95e16b16	CHEBI:16977	pathwaymech:consumes	WikiPathways:WP5060/d013c	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML d076f connects normalized CHEBI:16977 as an input of interaction d013c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='d076f']/Graphics; /Pathway/DataNode[@GraphId='f7d60']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-74_23cbd3a51209	UniProtKB:P07862	pathwaymech:catalyzes	WikiPathways:WP5060/cdc0a	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML e8b24 connects normalized UniProtKB:P07862 as a catalyst of interaction cdc0a."", ""source_locator"": ""/Pathway/Interaction[@GraphId='e8b24']/Graphics; /Pathway/DataNode[@GraphId='ee00f']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-75_f8ba48bccaf5	UniProtKB:P0AF16	pathwaymech:enables	WikiPathways:WP5060/d89b1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML b80a0 connects normalized UniProtKB:P0AF16 as an enabling enzyme component of interaction d89b1."", ""source_locator"": ""/Pathway/Interaction[@GraphId='b80a0']/Graphics; /Pathway/DataNode[@GraphId='c74ae']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-76_4b9827f987e1	CHEBI:16141	pathwaymech:consumes	WikiPathways:WP5060/adda4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML f27ff connects normalized CHEBI:16141 as an input of interaction adda4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='f27ff']/Graphics; /Pathway/DataNode[@GraphId='fb1b0']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-77_a0d7f6a7da3e	UniProtKB:P02918	pathwaymech:catalyzes	WikiPathways:WP5060/d89b1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML eaf5c connects normalized UniProtKB:P02918 as a catalyst of interaction d89b1."", ""source_locator"": ""/Pathway/Interaction[@GraphId='eaf5c']/Graphics; /Pathway/DataNode[@GraphId='f3e57']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-78_5d2154c5157a	UniProtKB:P14900	pathwaymech:catalyzes	WikiPathways:WP5060/eb85c	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML c3287 connects normalized UniProtKB:P14900 as a catalyst of interaction eb85c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='c3287']/Graphics; /Pathway/DataNode[@GraphId='c490a']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-79_a7111950a042	UniProtKB:P17952	pathwaymech:catalyzes	WikiPathways:WP5060/d013c	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML c5421 connects normalized UniProtKB:P17952 as a catalyst of interaction d013c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='c5421']/Graphics; /Pathway/DataNode[@GraphId='be995']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-80_2ebd38f16833	UniProtKB:P0A749	pathwaymech:catalyzes	WikiPathways:WP5060/e2f23	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML d5859 connects normalized UniProtKB:P0A749 as a catalyst of interaction e2f23."", ""source_locator"": ""/Pathway/Interaction[@GraphId='d5859']/Graphics; /Pathway/DataNode[@GraphId='b957f']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-81_c843d06732d5	UniProtKB:P08373	pathwaymech:catalyzes	WikiPathways:WP5060/b8d40	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML a1f97 connects normalized UniProtKB:P08373 as a catalyst of interaction b8d40."", ""source_locator"": ""/Pathway/Interaction[@GraphId='a1f97']/Graphics; /Pathway/DataNode[@GraphId='ccbe3']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-82_31b0e9406070	CHEBI:29986	pathwaymech:consumes	WikiPathways:WP5060/eb85c	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML a2a7d connects normalized CHEBI:29986 as an input of interaction eb85c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='a2a7d']/Graphics; /Pathway/DataNode[@GraphId='b18c7']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-83_768ac4a4f54c	UniProtKB:P22634	pathwaymech:catalyzes	WikiPathways:WP5060/d5182	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML e65f6 connects normalized UniProtKB:P22634 as a catalyst of interaction d5182."", ""source_locator"": ""/Pathway/Interaction[@GraphId='e65f6']/Graphics; /Pathway/DataNode[@GraphId='f39e3']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-84_924815d9e3d8	UniProtKB:P22188	pathwaymech:catalyzes	WikiPathways:WP5060/eff80	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML b5eed connects normalized UniProtKB:P22188 as a catalyst of interaction eff80."", ""source_locator"": ""/Pathway/Interaction[@GraphId='b5eed']/Graphics; /Pathway/DataNode[@GraphId='f7f2e']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-85_1b0c7ffc7076	CHEBI:16576	pathwaymech:consumes	WikiPathways:WP5060/b8180	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML ca472 connects normalized CHEBI:16576 as an input of interaction b8180."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ca472']/Graphics; /Pathway/DataNode[@GraphId='abc1f']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-86_6b1f895b6019	UniProtKB:P60932	pathwaymech:catalyzes	WikiPathways:WP5060/fb09e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML e1c23 connects normalized UniProtKB:P60932 as a catalyst of interaction fb09e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='e1c23']/Graphics; /Pathway/DataNode[@GraphId='baff9']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-87_fe532937d27b	UniProtKB:P17443	pathwaymech:catalyzes	WikiPathways:WP5060/f53c7	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML e2e96 connects normalized UniProtKB:P17443 as a catalyst of interaction f53c7."", ""source_locator"": ""/Pathway/Interaction[@GraphId='e2e96']/Graphics; /Pathway/DataNode[@GraphId='f9f7a']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-88_5afca91e3eaa	UniProtKB:P76577	pathwaymech:catalyzes	WikiPathways:WP5060/d89b1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML f68a1 connects normalized UniProtKB:P76577 as a catalyst of interaction d89b1."", ""source_locator"": ""/Pathway/Interaction[@GraphId='f68a1']/Graphics; /Pathway/DataNode[@GraphId='abaac']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-89_69e2cb2f3211	UniProtKB:P0ACC7	pathwaymech:catalyzes	WikiPathways:WP5060/f628a	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML cfa25 connects normalized UniProtKB:P0ACC7 as a catalyst of interaction f628a."", ""source_locator"": ""/Pathway/Interaction[@GraphId='cfa25']/Graphics; /Pathway/DataNode[@GraphId='d088e']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-90_4bd56384d83c	CHEBI:15351	pathwaymech:consumes	WikiPathways:WP5060/bcf55	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML d0579 connects normalized CHEBI:15351 as an input of interaction bcf55."", ""source_locator"": ""/Pathway/Interaction[@GraphId='d0579']/Graphics; /Pathway/DataNode[@GraphId='c9312']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-91_c80a93ec74c6	CHEBI:58702	pathwaymech:consumes	WikiPathways:WP5060/e2f23	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML f3504 connects normalized CHEBI:58702 as an input of interaction e2f23."", ""source_locator"": ""/Pathway/Interaction[@GraphId='f3504']/Graphics; /Pathway/DataNode[@GraphId='b9c50']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-92_985896b033ae	UniProtKB:P46022	pathwaymech:catalyzes	WikiPathways:WP5060/d89b1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML bebbb connects normalized UniProtKB:P46022 as a catalyst of interaction d89b1."", ""source_locator"": ""/Pathway/Interaction[@GraphId='bebbb']/Graphics; /Pathway/DataNode[@GraphId='ccfb0']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-93_37e3bb36c35d	UniProtKB:P11880	pathwaymech:catalyzes	WikiPathways:WP5060/b8180	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML ca145 connects normalized UniProtKB:P11880 as a catalyst of interaction b8180."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ca145']/Graphics; /Pathway/DataNode[@GraphId='e1e13']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-94_23e403bc76a6	UniProtKB:P0ABG4	pathwaymech:catalyzes	WikiPathways:WP5060/d89b1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML ea2ce connects normalized UniProtKB:P0ABG4 as a catalyst of interaction d89b1."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ea2ce']/Graphics; /Pathway/DataNode[@GraphId='efb9c']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-95_619aa2b265cf	UniProtKB:P02919	pathwaymech:catalyzes	WikiPathways:WP5060/d89b1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML d24b8 connects normalized UniProtKB:P02919 as a catalyst of interaction d89b1."", ""source_locator"": ""/Pathway/Interaction[@GraphId='d24b8']/Graphics; /Pathway/DataNode[@GraphId='bba64']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-96_5c0e57c440e1	CHEBI:16474	pathwaymech:consumes	WikiPathways:WP5060/b8d40	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML ccc5e connects normalized CHEBI:16474 as an input of interaction b8d40."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ccc5e']/Graphics; /Pathway/DataNode[@GraphId='f223e']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-97_e1e7b8273bc0	UniProtKB:P31120	pathwaymech:catalyzes	WikiPathways:WP5060/ebc50	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML c9642 connects normalized UniProtKB:P31120 as a catalyst of interaction ebc50."", ""source_locator"": ""/Pathway/Interaction[@GraphId='c9642']/Graphics; /Pathway/DataNode[@GraphId='e1221']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-98_7ebe5972e5b9	UniProtKB:P0ACC7	pathwaymech:catalyzes	WikiPathways:WP5060/bcf55	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML eb928 connects normalized UniProtKB:P0ACC7 as a catalyst of interaction bcf55."", ""source_locator"": ""/Pathway/Interaction[@GraphId='eb928']/Graphics; /Pathway/DataNode[@GraphId='d2a68']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-99_3d246bb6e4e2	UniProtKB:P0AE16	pathwaymech:catalyzes	WikiPathways:WP5060/b5af5	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML c0868 connects normalized UniProtKB:P0AE16 as a catalyst of interaction b5af5."", ""source_locator"": ""/Pathway/Interaction[@GraphId='c0868']/Graphics; /Pathway/DataNode[@GraphId='ce1e6']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-100_988544af9c05	UniProtKB:P0AF18	pathwaymech:catalyzes	WikiPathways:WP5060/c131c	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML df53a connects normalized UniProtKB:P0AF18 as a catalyst of interaction c131c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='df53a']/Graphics; /Pathway/DataNode[@GraphId='f1e91']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-101_73a95288682c	UniProtKB:P76535	pathwaymech:catalyzes	WikiPathways:WP5060/idb435b98e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML e6b4e connects normalized UniProtKB:P76535 as a catalyst of interaction idb435b98e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='e6b4e']/Graphics; /Pathway/DataNode[@GraphId='a4c89']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-102_a0496b409606	UniProtKB:P77570	pathwaymech:catalyzes	WikiPathways:WP5060/af315	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML f671e connects normalized UniProtKB:P77570 as a catalyst of interaction af315."", ""source_locator"": ""/Pathway/Interaction[@GraphId='f671e']/Graphics; /Pathway/DataNode[@GraphId='d3c21']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-103_364c91cdff77	UniProtKB:P77272	pathwaymech:catalyzes	WikiPathways:WP5060/eab24	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML c18d0 connects normalized UniProtKB:P77272 as a catalyst of interaction eab24."", ""source_locator"": ""/Pathway/Interaction[@GraphId='c18d0']/Graphics; /Pathway/DataNode[@GraphId='adec4']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-104_0fd107b0b879	UniProtKB:P75959	pathwaymech:catalyzes	WikiPathways:WP5060/c0f79	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML f1a29 connects normalized UniProtKB:P75959 as a catalyst of interaction c0f79."", ""source_locator"": ""/Pathway/Interaction[@GraphId='f1a29']/Graphics; /Pathway/DataNode[@GraphId='d5433']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-105_5c5c81bcea4a	UniProtKB:P0A759	pathwaymech:catalyzes	WikiPathways:WP5060/ac9d2	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML ecc1f connects normalized UniProtKB:P0A759 as a catalyst of interaction ac9d2."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ecc1f']/Graphics; /Pathway/DataNode[@GraphId='ca4dd']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-106_cc7d999e7fa0	UniProtKB:P37773	pathwaymech:catalyzes	WikiPathways:WP5060/e8b23	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML d6bb0 connects normalized UniProtKB:P37773 as a catalyst of interaction e8b23."", ""source_locator"": ""/Pathway/Interaction[@GraphId='d6bb0']/Graphics; /Pathway/DataNode[@GraphId='a948d']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-107_11437677b20d	UniProtKB:P29012	pathwaymech:catalyzes	WikiPathways:WP5060/id535c37a4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML b569e connects normalized UniProtKB:P29012 as a catalyst of interaction id535c37a4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='b569e']/Graphics; /Pathway/DataNode[@GraphId='a7a3b']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_causal-review-108_2426238f09c2	WikiPathways:WP5060/b423c	pathwaymech:produces	CHEBI:15570	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP5060		"[{""reference_id"": ""WikiPathways:WP5060"", ""source_assertion"": ""GPML de69c connects normalized CHEBI:15570 as an output of interaction b423c."", ""source_locator"": ""/Pathway/Interaction[@GraphId='de69c']/Graphics; /Pathway/DataNode[@GraphId='a68a3']""}]"	"[{""id"": ""WikiPathways:WP5060"", ""source_sha256"": ""89ff3159afa8467e032b242c748fc0127c4c5f4d0a936ca0669ad8d45ae3a16e"", ""source_version"": ""WP5060_r142449"", ""title"": ""WP5060 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP5060/WP5060.gpml""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-f980dfd5e226_ce774e4c52b0	UniProtKB:P0ACC7	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ACC7	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:17473010) Binds 1 Mg(2+) ion per subunit (PubMed:17473010). Can also use Co(2+) ion to a lesser extent (PubMed:11329257). UniProt note evidence: ECO:0000269 (PubMed:11329257); ECO:0000269 (PubMed:17473010)	"[{""reference_id"": ""UniProtKB:P0ACC7"", ""source_assertion"": ""UniProtKB:P0ACC7 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/10/comments/0/cofactors/0; /results/10/comments/0/note""}]"	"[{""id"": ""UniProtKB:P0ACC7"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P0ACC7 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-730175633563_1c3295eedc4b	UniProtKB:P0ACC7	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ACC7	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:11329257) Binds 1 Mg(2+) ion per subunit (PubMed:17473010). Can also use Co(2+) ion to a lesser extent (PubMed:11329257). UniProt note evidence: ECO:0000269 (PubMed:11329257); ECO:0000269 (PubMed:17473010)	"[{""reference_id"": ""UniProtKB:P0ACC7"", ""source_assertion"": ""UniProtKB:P0ACC7 annotates CHEBI:48828 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/10/comments/0/cofactors/1; /results/10/comments/0/note""}]"	"[{""id"": ""UniProtKB:P0ACC7"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P0ACC7 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-759a73319cd8_c4f0cbc34d11	UniProtKB:P31120	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31120	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) ion per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P31120"", ""source_assertion"": ""UniProtKB:P31120 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/22/comments/0/cofactors/0; /results/22/comments/0/note""}]"	"[{""id"": ""UniProtKB:P31120"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P31120 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-c6b0f1b4d9d2_ac67d30d14de	UniProtKB:P22188	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P22188	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_00208)	"[{""reference_id"": ""UniProtKB:P22188"", ""source_assertion"": ""UniProtKB:P22188 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/20/comments/0/cofactors/0""}]"	"[{""id"": ""UniProtKB:P22188"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P22188 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-eb35f741d10c_f9f1f5678a9b	UniProtKB:P14900	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P14900	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000305 (PubMed:1765076)	"[{""reference_id"": ""UniProtKB:P14900"", ""source_assertion"": ""UniProtKB:P14900 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/16/comments/0/cofactors/0""}]"	"[{""id"": ""UniProtKB:P14900"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P14900 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-36fe62f439e2_3f5d68da6755	UniProtKB:P08373	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08373	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P08373"", ""source_assertion"": ""UniProtKB:P08373 annotates CHEBI:57692 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/4/comments/0/cofactors/0""}]"	"[{""id"": ""UniProtKB:P08373"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P08373 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-43626192c680_c4c1bdd999ba	UniProtKB:P0A6W3	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6W3	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_00038); ECO:0000269 (PubMed:215212) Replacement of Mg(2+) by Mn(2+) restores only 10% of the activity. UniProt note evidence: ECO:0000269 (PubMed:215212)	"[{""reference_id"": ""UniProtKB:P0A6W3"", ""source_assertion"": ""UniProtKB:P0A6W3 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/6/comments/0/cofactors/0; /results/6/comments/0/note""}]"	"[{""id"": ""UniProtKB:P0A6W3"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P0A6W3 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-ac99c0b401aa_31126a91a25f	UniProtKB:P07862	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07862	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 2 magnesium or manganese ions per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P07862"", ""source_assertion"": ""UniProtKB:P07862 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/3/comments/0/cofactors/0; /results/3/comments/0/note""}]"	"[{""id"": ""UniProtKB:P07862"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P07862 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-c93684965276_163b64a75a5b	UniProtKB:P07862	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07862	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 2 magnesium or manganese ions per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P07862"", ""source_assertion"": ""UniProtKB:P07862 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/3/comments/0/cofactors/1; /results/3/comments/0/note""}]"	"[{""id"": ""UniProtKB:P07862"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P07862 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-5e6c07e8ae3e_dba680e654e3	UniProtKB:P29012	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P29012	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P29012"", ""source_assertion"": ""UniProtKB:P29012 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/43/comments/0/cofactors/0""}]"	"[{""id"": ""UniProtKB:P29012"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P29012 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-0027a250b21a_eea263a004ad	UniProtKB:P0A6B4	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6B4	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:18434499)	"[{""reference_id"": ""UniProtKB:P0A6B4"", ""source_assertion"": ""UniProtKB:P0A6B4 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/5/comments/0/cofactors/0""}]"	"[{""id"": ""UniProtKB:P0A6B4"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P0A6B4 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-c625464647c8_d9c47b6de266	UniProtKB:P37773	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37773	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_02020); ECO:0000269 (PubMed:17384195)	"[{""reference_id"": ""UniProtKB:P37773"", ""source_assertion"": ""UniProtKB:P37773 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/23/comments/0/cofactors/0""}]"	"[{""id"": ""UniProtKB:P37773"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P37773 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-382edfa732b2_64d84616b7b9	UniProtKB:P0AF18	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF18	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048) Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+). UniProt note evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048)	"[{""reference_id"": ""UniProtKB:P0AF18"", ""source_assertion"": ""UniProtKB:P0AF18 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/14/comments/0/cofactors/0; /results/14/comments/0/note""}]"	"[{""id"": ""UniProtKB:P0AF18"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P0AF18 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-002bfe3b1c1d_9d38c02a42a3	UniProtKB:P0AF18	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF18	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048) Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+). UniProt note evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048)	"[{""reference_id"": ""UniProtKB:P0AF18"", ""source_assertion"": ""UniProtKB:P0AF18 annotates CHEBI:48828 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/14/comments/0/cofactors/1; /results/14/comments/0/note""}]"	"[{""id"": ""UniProtKB:P0AF18"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P0AF18 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-05c07d39f230_70f3d421a629	UniProtKB:P0AF18	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF18	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048) Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+). UniProt note evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048)	"[{""reference_id"": ""UniProtKB:P0AF18"", ""source_assertion"": ""UniProtKB:P0AF18 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/14/comments/0/cofactors/2; /results/14/comments/0/note""}]"	"[{""id"": ""UniProtKB:P0AF18"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P0AF18 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-aae09477d803_c205d94ede7a	UniProtKB:P0AF18	pathwaymech:has_cofactor	CHEBI:48775	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF18	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048) Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+). UniProt note evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048)	"[{""reference_id"": ""UniProtKB:P0AF18"", ""source_assertion"": ""UniProtKB:P0AF18 annotates CHEBI:48775 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/14/comments/0/cofactors/3; /results/14/comments/0/note""}]"	"[{""id"": ""UniProtKB:P0AF18"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P0AF18 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-4f265d5f4a30_15de9a0452dd	UniProtKB:P0AF18	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF18	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048) Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+). UniProt note evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048)	"[{""reference_id"": ""UniProtKB:P0AF18"", ""source_assertion"": ""UniProtKB:P0AF18 annotates CHEBI:29033 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/14/comments/0/cofactors/4; /results/14/comments/0/note""}]"	"[{""id"": ""UniProtKB:P0AF18"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P0AF18 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-e63d0ba9e044_75609ad80590	UniProtKB:P0AF18	pathwaymech:has_cofactor	CHEBI:49786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AF18	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048) Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+). UniProt note evidence: ECO:0000269 (PubMed:16630633); ECO:0000269 (PubMed:17567047); ECO:0000269 (PubMed:17567048)	"[{""reference_id"": ""UniProtKB:P0AF18"", ""source_assertion"": ""UniProtKB:P0AF18 annotates CHEBI:49786 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/14/comments/0/cofactors/5; /results/14/comments/0/note""}]"	"[{""id"": ""UniProtKB:P0AF18"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P0AF18 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP5060_cofactor-057b6020b49c_d32a97f84842	UniProtKB:P13016	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P13016	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P82974) Zn(2+) is required for amidase activity. UniProt note evidence: ECO:0000250 (UniProtKB:P82974)	"[{""reference_id"": ""UniProtKB:P13016"", ""source_assertion"": ""UniProtKB:P13016 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c] #/results/35/comments/0/cofactors/0; /results/35/comments/0/note""}]"	"[{""id"": ""UniProtKB:P13016"", ""source_sha256"": ""f2a2d9df603885068af58d89787438192b8c396d89a4cc931ac7bbab93a74c5c"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P13016 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=accession%3AP02918+OR+accession%3AP02919+OR+accession%3AP06721+OR+accession%3AP07862+OR+accession%3AP08373+OR+accession%3AP0A6B4+OR+accession%3AP0A6W3+OR+accession%3AP0A749+OR+accession%3AP0A759+OR+accession%3AP0ABG4+OR+accession%3AP0ACC7+OR+accession%3AP0AD68+OR+accession%3AP0AE16+OR+accession%3AP0AF16+OR+accession%3AP0AF18+OR+accession%3AP11880+OR+accession%3AP13016+OR+accession%3AP14900+OR+accession%3AP17169+OR+accession%3AP17443+OR+accession%3AP17952+OR+accession%3AP22188+OR+accession%3AP22634+OR+accession%3AP29012+OR+accession%3AP31120+OR+accession%3AP37773+OR+accession%3AP46022+OR+accession%3AP60932+OR+accession%3AP75949+OR+accession%3AP75959+OR+accession%3AP76008+OR+accession%3AP76535+OR+accession%3AP76577+OR+accession%3AP77272+OR+accession%3AP77570+OR+accession%3AP95189+OR+accession%3AP9WFZ5+OR+accession%3AP9WJM7+OR+accession%3AP9WJM9+OR+accession%3AP9WJN1+OR+accession%3AP9WKI1+OR+accession%3AP9WMY7+OR+accession%3AP9WN11+OR+accession%3AP9WQ19+OR+accession%3AP9WQ21+OR+accession%3AP9WQ23+OR+accession%3AQ2TL65&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_edge-001_d8b65a0576db	gomodel:AMP-DEPHOSPHORYLATION-RXN	RO:0002234	CHEBI:16335	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION		"[{""reference_id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_assertion"": ""The model asserts gomodel:AMP-DEPHOSPHORYLATION-RXN RO:0002234 gomodel:CHEBI_16335_AMP-DEPHOSPHORYLATION-RXN."", ""source_locator"": ""./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json#/facts/0; endpoint types: /individuals/0/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json"", ""title"": ""GO-CAM periplasmic NAD degradation model YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_edge-003_bd5695ead129	gomodel:NADPYROPHOSPHAT-RXN	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION		"[{""reference_id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_assertion"": ""The model asserts gomodel:NADPYROPHOSPHAT-RXN RO:0002234 gomodel:CHEBI_456215_NADPYROPHOSPHAT-RXN."", ""source_locator"": ""./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json#/facts/2; endpoint types: /individuals/9/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json"", ""title"": ""GO-CAM periplasmic NAD degradation model YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_edge-004_acde2ae1d0ed	gomodel:AMP-DEPHOSPHORYLATION-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION		"[{""reference_id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_assertion"": ""The model asserts gomodel:AMP-DEPHOSPHORYLATION-RXN RO:0002233 gomodel:CHEBI_15377_AMP-DEPHOSPHORYLATION-RXN."", ""source_locator"": ""./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json#/facts/3; endpoint types: /individuals/0/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json"", ""title"": ""GO-CAM periplasmic NAD degradation model YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_edge-005_1ee6735acc4f	SGD:S000003035	pathwaymech:enables	gomodel:NADPYROPHOSPHAT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION		"[{""reference_id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_assertion"": ""The model asserts gomodel:NADPYROPHOSPHAT-RXN RO:0002333 gomodel:YGL067W-MONOMER_NADPYROPHOSPHAT-RXN_controller."", ""source_locator"": ""./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json#/facts/4; endpoint types: /individuals/9/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json"", ""title"": ""GO-CAM periplasmic NAD degradation model YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_edge-006_b32ec0ad5557	gomodel:NADPYROPHOSPHAT-RXN	BFO:0000050	GO:0019677	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION		"[{""reference_id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_assertion"": ""The model asserts gomodel:NADPYROPHOSPHAT-RXN BFO:0000050 gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION/YeastPathways_PERIPLASMA-NAD-DEGRADATION."", ""source_locator"": ""./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json#/facts/5; endpoint types: /individuals/9/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json"", ""title"": ""GO-CAM periplasmic NAD degradation model YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_edge-007_786d33e2a14a	gomodel:NADPYROPHOSPHAT-RXN	RO:0002234	CHEBI:14649	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION		"[{""reference_id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_assertion"": ""The model asserts gomodel:NADPYROPHOSPHAT-RXN RO:0002234 gomodel:CHEBI_14649_NADPYROPHOSPHAT-RXN."", ""source_locator"": ""./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json#/facts/6; endpoint types: /individuals/9/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json"", ""title"": ""GO-CAM periplasmic NAD degradation model YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_edge-008_c9c7f4912faf	gomodel:AMP-DEPHOSPHORYLATION-RXN	BFO:0000050	GO:0019677	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION		"[{""reference_id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_assertion"": ""The model asserts gomodel:AMP-DEPHOSPHORYLATION-RXN BFO:0000050 gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION/YeastPathways_PERIPLASMA-NAD-DEGRADATION."", ""source_locator"": ""./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json#/facts/7; endpoint types: /individuals/0/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json"", ""title"": ""GO-CAM periplasmic NAD degradation model YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_edge-009_eea7f71621db	gomodel:NADPYROPHOSPHAT-RXN	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION		"[{""reference_id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_assertion"": ""The model asserts gomodel:NADPYROPHOSPHAT-RXN RO:0002233 gomodel:CHEBI_57540_NADPYROPHOSPHAT-RXN."", ""source_locator"": ""./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json#/facts/8; endpoint types: /individuals/9/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json"", ""title"": ""GO-CAM periplasmic NAD degradation model YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_edge-010_a22651ddc060	gomodel:NADPYROPHOSPHAT-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION		"[{""reference_id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_assertion"": ""The model asserts gomodel:NADPYROPHOSPHAT-RXN RO:0002234 gomodel:CHEBI_15378_NADPYROPHOSPHAT-RXN."", ""source_locator"": ""./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json#/facts/9; endpoint types: /individuals/9/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json"", ""title"": ""GO-CAM periplasmic NAD degradation model YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_edge-011_c17cfec48819	SGD:S000001245	pathwaymech:enables	gomodel:AMP-DEPHOSPHORYLATION-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION		"[{""reference_id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_assertion"": ""The model asserts gomodel:AMP-DEPHOSPHORYLATION-RXN RO:0002333 gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION/6a4c244800003007."", ""source_locator"": ""./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json#/facts/10; endpoint types: /individuals/0/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json"", ""title"": ""GO-CAM periplasmic NAD degradation model YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_edge-013_4e8443216fef	gomodel:AMP-DEPHOSPHORYLATION-RXN	RO:0002233	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION		"[{""reference_id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_assertion"": ""The model asserts gomodel:AMP-DEPHOSPHORYLATION-RXN RO:0002233 gomodel:CHEBI_456215_NADPYROPHOSPHAT-RXN."", ""source_locator"": ""./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json#/facts/12; endpoint types: /individuals/0/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json"", ""title"": ""GO-CAM periplasmic NAD degradation model YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_edge-014_bd8274443714	gomodel:NADPYROPHOSPHAT-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION		"[{""reference_id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_assertion"": ""The model asserts gomodel:NADPYROPHOSPHAT-RXN RO:0002233 gomodel:CHEBI_15377_NADPYROPHOSPHAT-RXN."", ""source_locator"": ""./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json#/facts/13; endpoint types: /individuals/9/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json"", ""title"": ""GO-CAM periplasmic NAD degradation model YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_edge-015_b2ed216a505d	gomodel:AMP-DEPHOSPHORYLATION-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION		"[{""reference_id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_assertion"": ""The model asserts gomodel:AMP-DEPHOSPHORYLATION-RXN RO:0002234 gomodel:CHEBI_43474_AMP-DEPHOSPHORYLATION-RXN."", ""source_locator"": ""./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json#/facts/14; endpoint types: /individuals/0/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-14; member ./YeastPathways_PERIPLASMA-NAD-DEGRADATION.json"", ""title"": ""GO-CAM periplasmic NAD degradation model YeastPathways_PERIPLASMA-NAD-DEGRADATION"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_location-1b052ba808b7_c5950a8b202d	SGD:S000003035	RO:0001025	GO:0005777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53164	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11361135)	"[{""reference_id"": ""UniProtKB:P53164"", ""source_assertion"": ""UniProtKB:P53164 annotates location Peroxisome (SL-0204)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2140/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53164"", ""source_assertion"": ""UniProtKB:P53164 has the exact SGD cross-reference SGD:S000003035."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2140/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53164"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53164 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_location-183a0f557e78_05e4dae53555	SGD:S000001245	RO:0001025	GO:0005576	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38887	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:35123996)	"[{""reference_id"": ""UniProtKB:P38887"", ""source_assertion"": ""UniProtKB:P38887 annotates location Secreted (SL-0243)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1493/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38887"", ""source_assertion"": ""UniProtKB:P38887 has the exact SGD cross-reference SGD:S000001245."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1493/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38887"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38887 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_location-73875ebcc726_c52d4bca4978	SGD:S000001245	RO:0001025	GO:0005773	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38887	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38887"", ""source_assertion"": ""UniProtKB:P38887 annotates location Vacuole (SL-0272)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1493/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38887"", ""source_assertion"": ""UniProtKB:P38887 has the exact SGD cross-reference SGD:S000001245."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1493/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38887"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38887 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_cofactor-68451c2ad295_b8374af83967	SGD:S000003035	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53164	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q9DCN1) Binds 3 Mg(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:Q9DCN1)	"[{""reference_id"": ""UniProtKB:P53164"", ""source_assertion"": ""UniProtKB:P53164 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2140/comments/0/cofactors/0; /results/2140/comments/0/note""}, {""reference_id"": ""UniProtKB:P53164"", ""source_assertion"": ""UniProtKB:P53164 has the exact SGD cross-reference SGD:S000003035."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2140/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53164"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53164 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_cofactor-2796f5bbf4d9_724f99a4ea54	SGD:S000003035	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53164	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q9DCN1) Binds 1 zinc ion per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:Q9DCN1)	"[{""reference_id"": ""UniProtKB:P53164"", ""source_assertion"": ""UniProtKB:P53164 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2140/comments/1/cofactors/0; /results/2140/comments/1/note""}, {""reference_id"": ""UniProtKB:P53164"", ""source_assertion"": ""UniProtKB:P53164 has the exact SGD cross-reference SGD:S000003035."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2140/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53164"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53164 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PERIPLASMA-NAD-DEGRADATION_cofactor-c9b4e60918e0_0a162d200850	SGD:S000001245	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38887	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P21589)	"[{""reference_id"": ""UniProtKB:P38887"", ""source_assertion"": ""UniProtKB:P38887 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1493/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P38887"", ""source_assertion"": ""UniProtKB:P38887 has the exact SGD cross-reference SGD:S000001245."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1493/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38887"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38887 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-001_202fa22c5c93	RHEA-COMP:17557	pathwaymech:consumes	RHEA:48405	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:48405	This is a whole generic aryl-carrier state, not free phosphopantetheine or an exact AsbD sequence. Chemical class coefficients do not specify enzyme assembly stoichiometry.	"[{""reference_id"": ""RHEA:48405"", ""source_assertion"": ""RHEA:48405 assigns RHEA-COMP:17557 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/48405 rh:substrates http://rdf.rhea-db.org/48404_L; http://rdf.rhea-db.org/48404_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_48404_compound_17557; rh:compound http://rdf.rhea-db.org/Compound_17557; rh:name and rh:reactivePart""}]"	"[{""id"": ""RHEA:48405"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 48405"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-002_b141460d3861	CHEBI:57287	pathwaymech:consumes	RHEA:48405	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:48405		"[{""reference_id"": ""RHEA:48405"", ""source_assertion"": ""RHEA:48405 assigns CHEBI:57287 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/48405 rh:substrates http://rdf.rhea-db.org/48404_L; http://rdf.rhea-db.org/48404_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_48404_compound_1264; rh:compound http://rdf.rhea-db.org/Compound_1264; rh:chebi""}]"	"[{""id"": ""RHEA:48405"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 48405"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-003_d48b4995b119	RHEA:48405	pathwaymech:produces	RHEA-COMP:15903	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:48405	This is a whole generic aryl-carrier state, not free phosphopantetheine or an exact AsbD sequence. Chemical class coefficients do not specify enzyme assembly stoichiometry.	"[{""reference_id"": ""RHEA:48405"", ""source_assertion"": ""RHEA:48405 assigns RHEA-COMP:15903 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/48405 rh:products http://rdf.rhea-db.org/48404_R; http://rdf.rhea-db.org/48404_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_48404_compound_15903; rh:compound http://rdf.rhea-db.org/Compound_15903; rh:name and rh:reactivePart""}]"	"[{""id"": ""RHEA:48405"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 48405"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-004_031671c9bd5a	RHEA:48405	pathwaymech:produces	CHEBI:58343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:48405		"[{""reference_id"": ""RHEA:48405"", ""source_assertion"": ""RHEA:48405 assigns CHEBI:58343 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/48405 rh:products http://rdf.rhea-db.org/48404_R; http://rdf.rhea-db.org/48404_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_48404_compound_1731; rh:compound http://rdf.rhea-db.org/Compound_1731; rh:chebi""}]"	"[{""id"": ""RHEA:48405"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 48405"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-005_2101c41c8647	RHEA:48405	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:48405		"[{""reference_id"": ""RHEA:48405"", ""source_assertion"": ""RHEA:48405 assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/48405 rh:products http://rdf.rhea-db.org/48404_R; http://rdf.rhea-db.org/48404_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_48404_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:48405"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 48405"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-006_0a783dbee069	CHEBI:16630	pathwaymech:consumes	RHEA:24849	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24849		"[{""reference_id"": ""RHEA:24849"", ""source_assertion"": ""RHEA:24849 assigns CHEBI:16630 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/24849 rh:substrates http://rdf.rhea-db.org/24848_L; http://rdf.rhea-db.org/24848_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_24848_compound_3489; rh:compound http://rdf.rhea-db.org/Compound_3489; rh:chebi""}]"	"[{""id"": ""RHEA:24849"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 24849"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-007_c3dfae4e45c4	RHEA:24849	pathwaymech:produces	CHEBI:36241	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24849		"[{""reference_id"": ""RHEA:24849"", ""source_assertion"": ""RHEA:24849 assigns CHEBI:36241 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/24849 rh:products http://rdf.rhea-db.org/24848_R; http://rdf.rhea-db.org/24848_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_24848_compound_3099; rh:compound http://rdf.rhea-db.org/Compound_3099; rh:chebi""}]"	"[{""id"": ""RHEA:24849"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 24849"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-008_208d81c5cced	RHEA:24849	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24849		"[{""reference_id"": ""RHEA:24849"", ""source_assertion"": ""RHEA:24849 assigns CHEBI:15377 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/24849 rh:products http://rdf.rhea-db.org/24848_R; http://rdf.rhea-db.org/24848_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_24848_compound_1283; rh:compound http://rdf.rhea-db.org/Compound_1283; rh:chebi""}]"	"[{""id"": ""RHEA:24849"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 24849"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-009_b9c02d47f7e2	CHEBI:36241	pathwaymech:consumes	RHEA:62469	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:62469		"[{""reference_id"": ""RHEA:62469"", ""source_assertion"": ""RHEA:62469 assigns CHEBI:36241 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/62469 rh:substrates http://rdf.rhea-db.org/62468_L; http://rdf.rhea-db.org/62468_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_62468_compound_3099; rh:compound http://rdf.rhea-db.org/Compound_3099; rh:chebi""}]"	"[{""id"": ""RHEA:62469"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62469"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-010_96946154ad3b	CHEBI:30616	pathwaymech:consumes	RHEA:62469	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:62469		"[{""reference_id"": ""RHEA:62469"", ""source_assertion"": ""RHEA:62469 assigns CHEBI:30616 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/62469 rh:substrates http://rdf.rhea-db.org/62468_L; http://rdf.rhea-db.org/62468_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_62468_compound_6372; rh:compound http://rdf.rhea-db.org/Compound_6372; rh:chebi""}]"	"[{""id"": ""RHEA:62469"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62469"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-011_c54b431699b4	CHEBI:15378	pathwaymech:consumes	RHEA:62469	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:62469		"[{""reference_id"": ""RHEA:62469"", ""source_assertion"": ""RHEA:62469 assigns CHEBI:15378 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/62469 rh:substrates http://rdf.rhea-db.org/62468_L; http://rdf.rhea-db.org/62468_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_62468_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:62469"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62469"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-012_92702ba3758c	RHEA:62469	pathwaymech:produces	CHEBI:144942	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:62469		"[{""reference_id"": ""RHEA:62469"", ""source_assertion"": ""RHEA:62469 assigns CHEBI:144942 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/62469 rh:products http://rdf.rhea-db.org/62468_R; http://rdf.rhea-db.org/62468_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_62468_compound_16102; rh:compound http://rdf.rhea-db.org/Compound_16102; rh:chebi""}]"	"[{""id"": ""RHEA:62469"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62469"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-013_3ccb8fdb5889	RHEA:62469	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:62469		"[{""reference_id"": ""RHEA:62469"", ""source_assertion"": ""RHEA:62469 assigns CHEBI:33019 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/62469 rh:products http://rdf.rhea-db.org/62468_R; http://rdf.rhea-db.org/62468_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_62468_compound_2106; rh:compound http://rdf.rhea-db.org/Compound_2106; rh:chebi""}]"	"[{""id"": ""RHEA:62469"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62469"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-014_37857e343501	CHEBI:144942	pathwaymech:consumes	RHEA:62477	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:62477		"[{""reference_id"": ""RHEA:62477"", ""source_assertion"": ""RHEA:62477 assigns CHEBI:144942 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/62477 rh:substrates http://rdf.rhea-db.org/62476_L; http://rdf.rhea-db.org/62476_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_62476_compound_16102; rh:compound http://rdf.rhea-db.org/Compound_16102; rh:chebi""}]"	"[{""id"": ""RHEA:62477"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62477"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-015_9ad1fe851b8f	RHEA-COMP:15903	pathwaymech:consumes	RHEA:62477	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:62477	This is a whole generic aryl-carrier state, not free phosphopantetheine or an exact AsbD sequence. Chemical class coefficients do not specify enzyme assembly stoichiometry.	"[{""reference_id"": ""RHEA:62477"", ""source_assertion"": ""RHEA:62477 assigns RHEA-COMP:15903 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/62477 rh:substrates http://rdf.rhea-db.org/62476_L; http://rdf.rhea-db.org/62476_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_62476_compound_15903; rh:compound http://rdf.rhea-db.org/Compound_15903; rh:name and rh:reactivePart""}]"	"[{""id"": ""RHEA:62477"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62477"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-016_151e8ddb7deb	RHEA:62477	pathwaymech:produces	RHEA-COMP:15941	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:62477	This is a whole generic aryl-carrier state, not free phosphopantetheine or an exact AsbD sequence. Chemical class coefficients do not specify enzyme assembly stoichiometry.	"[{""reference_id"": ""RHEA:62477"", ""source_assertion"": ""RHEA:62477 assigns RHEA-COMP:15941 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/62477 rh:products http://rdf.rhea-db.org/62476_R; http://rdf.rhea-db.org/62476_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_62476_compound_15941; rh:compound http://rdf.rhea-db.org/Compound_15941; rh:name and rh:reactivePart""}]"	"[{""id"": ""RHEA:62477"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62477"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-017_3a3a030032d0	RHEA:62477	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:62477		"[{""reference_id"": ""RHEA:62477"", ""source_assertion"": ""RHEA:62477 assigns CHEBI:456215 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/62477 rh:products http://rdf.rhea-db.org/62476_R; http://rdf.rhea-db.org/62476_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_62476_compound_2590; rh:compound http://rdf.rhea-db.org/Compound_2590; rh:chebi""}]"	"[{""id"": ""RHEA:62477"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62477"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-018_a099b8ad928c	RHEA:62477	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:62477		"[{""reference_id"": ""RHEA:62477"", ""source_assertion"": ""RHEA:62477 assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/62477 rh:products http://rdf.rhea-db.org/62476_R; http://rdf.rhea-db.org/62476_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_62476_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:62477"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62477"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-019_d8a8ccf78994	CHEBI:57834	pathwaymech:consumes	RHEA:63809	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63809		"[{""reference_id"": ""RHEA:63809"", ""source_assertion"": ""RHEA:63809 assigns CHEBI:57834 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63809 rh:substrates http://rdf.rhea-db.org/63808_L; http://rdf.rhea-db.org/63808_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63808_compound_2557; rh:compound http://rdf.rhea-db.org/Compound_2557; rh:chebi""}]"	"[{""id"": ""RHEA:63809"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63809"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-020_247db73c8742	CHEBI:16947	pathwaymech:consumes	RHEA:63809	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63809		"[{""reference_id"": ""RHEA:63809"", ""source_assertion"": ""RHEA:63809 assigns CHEBI:16947 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63809 rh:substrates http://rdf.rhea-db.org/63808_L; http://rdf.rhea-db.org/63808_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63808_compound_5244; rh:compound http://rdf.rhea-db.org/Compound_5244; rh:chebi""}]"	"[{""id"": ""RHEA:63809"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63809"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-021_2cd4080e51a1	CHEBI:30616	pathwaymech:consumes	RHEA:63809	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63809		"[{""reference_id"": ""RHEA:63809"", ""source_assertion"": ""RHEA:63809 assigns CHEBI:30616 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63809 rh:substrates http://rdf.rhea-db.org/63808_L; http://rdf.rhea-db.org/63808_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63808_compound_6372; rh:compound http://rdf.rhea-db.org/Compound_6372; rh:chebi""}]"	"[{""id"": ""RHEA:63809"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63809"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-022_60d184fc2988	RHEA:63809	pathwaymech:produces	CHEBI:149586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63809	The issued native/ChEBI intermediate does not specify absolute citrate-derived stereochemistry. The graph preserves that class and does not assert racemic physiology or acceptance of all stereoisomers.	"[{""reference_id"": ""RHEA:63809"", ""source_assertion"": ""RHEA:63809 assigns CHEBI:149586 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63809 rh:products http://rdf.rhea-db.org/63808_R; http://rdf.rhea-db.org/63808_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63808_compound_16439; rh:compound http://rdf.rhea-db.org/Compound_16439; rh:chebi""}]"	"[{""id"": ""RHEA:63809"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63809"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-023_3cf72d37d648	RHEA:63809	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63809		"[{""reference_id"": ""RHEA:63809"", ""source_assertion"": ""RHEA:63809 assigns CHEBI:456215 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63809 rh:products http://rdf.rhea-db.org/63808_R; http://rdf.rhea-db.org/63808_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63808_compound_2590; rh:compound http://rdf.rhea-db.org/Compound_2590; rh:chebi""}]"	"[{""id"": ""RHEA:63809"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63809"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-024_9bf050604b07	RHEA:63809	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63809		"[{""reference_id"": ""RHEA:63809"", ""source_assertion"": ""RHEA:63809 assigns CHEBI:33019 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63809 rh:products http://rdf.rhea-db.org/63808_R; http://rdf.rhea-db.org/63808_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63808_compound_2106; rh:compound http://rdf.rhea-db.org/Compound_2106; rh:chebi""}]"	"[{""id"": ""RHEA:63809"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63809"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-025_db57eb06197e	RHEA:63809	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63809		"[{""reference_id"": ""RHEA:63809"", ""source_assertion"": ""RHEA:63809 assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63809 rh:products http://rdf.rhea-db.org/63808_R; http://rdf.rhea-db.org/63808_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63808_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:63809"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63809"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-026_599cd329e939	CHEBI:149586	pathwaymech:consumes	RHEA:63813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63813	The issued native/ChEBI intermediate does not specify absolute citrate-derived stereochemistry. The graph preserves that class and does not assert racemic physiology or acceptance of all stereoisomers.	"[{""reference_id"": ""RHEA:63813"", ""source_assertion"": ""RHEA:63813 assigns CHEBI:149586 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63813 rh:substrates http://rdf.rhea-db.org/63812_L; http://rdf.rhea-db.org/63812_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63812_compound_16439; rh:compound http://rdf.rhea-db.org/Compound_16439; rh:chebi""}]"	"[{""id"": ""RHEA:63813"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63813"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-027_99e8dfeb82f4	CHEBI:57834	pathwaymech:consumes	RHEA:63813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63813		"[{""reference_id"": ""RHEA:63813"", ""source_assertion"": ""RHEA:63813 assigns CHEBI:57834 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63813 rh:substrates http://rdf.rhea-db.org/63812_L; http://rdf.rhea-db.org/63812_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63812_compound_2557; rh:compound http://rdf.rhea-db.org/Compound_2557; rh:chebi""}]"	"[{""id"": ""RHEA:63813"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63813"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-028_9b4e7c4978ae	CHEBI:30616	pathwaymech:consumes	RHEA:63813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63813		"[{""reference_id"": ""RHEA:63813"", ""source_assertion"": ""RHEA:63813 assigns CHEBI:30616 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63813 rh:substrates http://rdf.rhea-db.org/63812_L; http://rdf.rhea-db.org/63812_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63812_compound_6372; rh:compound http://rdf.rhea-db.org/Compound_6372; rh:chebi""}]"	"[{""id"": ""RHEA:63813"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63813"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-029_f2e4719d9bb6	RHEA:63813	pathwaymech:produces	CHEBI:149592	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63813		"[{""reference_id"": ""RHEA:63813"", ""source_assertion"": ""RHEA:63813 assigns CHEBI:149592 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63813 rh:products http://rdf.rhea-db.org/63812_R; http://rdf.rhea-db.org/63812_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63812_compound_16440; rh:compound http://rdf.rhea-db.org/Compound_16440; rh:chebi""}]"	"[{""id"": ""RHEA:63813"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63813"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-030_056625508a57	RHEA:63813	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63813		"[{""reference_id"": ""RHEA:63813"", ""source_assertion"": ""RHEA:63813 assigns CHEBI:456215 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63813 rh:products http://rdf.rhea-db.org/63812_R; http://rdf.rhea-db.org/63812_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63812_compound_2590; rh:compound http://rdf.rhea-db.org/Compound_2590; rh:chebi""}]"	"[{""id"": ""RHEA:63813"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63813"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-031_b736e0df423a	RHEA:63813	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63813		"[{""reference_id"": ""RHEA:63813"", ""source_assertion"": ""RHEA:63813 assigns CHEBI:33019 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63813 rh:products http://rdf.rhea-db.org/63812_R; http://rdf.rhea-db.org/63812_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63812_compound_2106; rh:compound http://rdf.rhea-db.org/Compound_2106; rh:chebi""}]"	"[{""id"": ""RHEA:63813"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63813"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-032_337ad2440194	RHEA:63813	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63813		"[{""reference_id"": ""RHEA:63813"", ""source_assertion"": ""RHEA:63813 assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63813 rh:products http://rdf.rhea-db.org/63812_R; http://rdf.rhea-db.org/63812_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63812_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:63813"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63813"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-033_9b18f86a8046	CHEBI:149586	pathwaymech:consumes	RHEA:64029	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:64029	The issued native/ChEBI intermediate does not specify absolute citrate-derived stereochemistry. The graph preserves that class and does not assert racemic physiology or acceptance of all stereoisomers.	"[{""reference_id"": ""RHEA:64029"", ""source_assertion"": ""RHEA:64029 assigns CHEBI:149586 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/64029 rh:substrates http://rdf.rhea-db.org/64028_L; http://rdf.rhea-db.org/64028_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_64028_compound_16439; rh:compound http://rdf.rhea-db.org/Compound_16439; rh:chebi""}]"	"[{""id"": ""RHEA:64029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 64029"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-034_aca7729f514c	RHEA-COMP:15941	pathwaymech:consumes	RHEA:64029	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:64029	This is a whole generic aryl-carrier state, not free phosphopantetheine or an exact AsbD sequence. Chemical class coefficients do not specify enzyme assembly stoichiometry.	"[{""reference_id"": ""RHEA:64029"", ""source_assertion"": ""RHEA:64029 assigns RHEA-COMP:15941 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/64029 rh:substrates http://rdf.rhea-db.org/64028_L; http://rdf.rhea-db.org/64028_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_64028_compound_15941; rh:compound http://rdf.rhea-db.org/Compound_15941; rh:name and rh:reactivePart""}]"	"[{""id"": ""RHEA:64029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 64029"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-035_4e5710bd1057	RHEA:64029	pathwaymech:produces	CHEBI:149593	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:64029	The issued native/ChEBI intermediate does not specify absolute citrate-derived stereochemistry. The graph preserves that class and does not assert racemic physiology or acceptance of all stereoisomers.	"[{""reference_id"": ""RHEA:64029"", ""source_assertion"": ""RHEA:64029 assigns CHEBI:149593 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/64029 rh:products http://rdf.rhea-db.org/64028_R; http://rdf.rhea-db.org/64028_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_64028_compound_16442; rh:compound http://rdf.rhea-db.org/Compound_16442; rh:chebi""}]"	"[{""id"": ""RHEA:64029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 64029"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-036_a853d3b12b65	RHEA:64029	pathwaymech:produces	RHEA-COMP:15903	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:64029	This is a whole generic aryl-carrier state, not free phosphopantetheine or an exact AsbD sequence. Chemical class coefficients do not specify enzyme assembly stoichiometry.	"[{""reference_id"": ""RHEA:64029"", ""source_assertion"": ""RHEA:64029 assigns RHEA-COMP:15903 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/64029 rh:products http://rdf.rhea-db.org/64028_R; http://rdf.rhea-db.org/64028_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_64028_compound_15903; rh:compound http://rdf.rhea-db.org/Compound_15903; rh:name and rh:reactivePart""}]"	"[{""id"": ""RHEA:64029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 64029"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-037_8105eed13508	RHEA:64029	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:64029		"[{""reference_id"": ""RHEA:64029"", ""source_assertion"": ""RHEA:64029 assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/64029 rh:products http://rdf.rhea-db.org/64028_R; http://rdf.rhea-db.org/64028_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_64028_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:64029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 64029"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-038_8e97c1cb4668	CHEBI:149593	pathwaymech:consumes	RHEA:63817	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63817	The issued native/ChEBI intermediate does not specify absolute citrate-derived stereochemistry. The graph preserves that class and does not assert racemic physiology or acceptance of all stereoisomers.	"[{""reference_id"": ""RHEA:63817"", ""source_assertion"": ""RHEA:63817 assigns CHEBI:149593 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63817 rh:substrates http://rdf.rhea-db.org/63816_L; http://rdf.rhea-db.org/63816_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63816_compound_16442; rh:compound http://rdf.rhea-db.org/Compound_16442; rh:chebi""}]"	"[{""id"": ""RHEA:63817"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63817"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-039_a3dbf3f2f75a	CHEBI:57834	pathwaymech:consumes	RHEA:63817	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63817		"[{""reference_id"": ""RHEA:63817"", ""source_assertion"": ""RHEA:63817 assigns CHEBI:57834 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63817 rh:substrates http://rdf.rhea-db.org/63816_L; http://rdf.rhea-db.org/63816_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63816_compound_2557; rh:compound http://rdf.rhea-db.org/Compound_2557; rh:chebi""}]"	"[{""id"": ""RHEA:63817"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63817"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-040_93fcda11c52e	CHEBI:30616	pathwaymech:consumes	RHEA:63817	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63817		"[{""reference_id"": ""RHEA:63817"", ""source_assertion"": ""RHEA:63817 assigns CHEBI:30616 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63817 rh:substrates http://rdf.rhea-db.org/63816_L; http://rdf.rhea-db.org/63816_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63816_compound_6372; rh:compound http://rdf.rhea-db.org/Compound_6372; rh:chebi""}]"	"[{""id"": ""RHEA:63817"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63817"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-041_b18ee0358eb5	RHEA:63817	pathwaymech:produces	CHEBI:149594	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63817	The issued native/ChEBI intermediate does not specify absolute citrate-derived stereochemistry. The graph preserves that class and does not assert racemic physiology or acceptance of all stereoisomers.	"[{""reference_id"": ""RHEA:63817"", ""source_assertion"": ""RHEA:63817 assigns CHEBI:149594 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63817 rh:products http://rdf.rhea-db.org/63816_R; http://rdf.rhea-db.org/63816_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63816_compound_16441; rh:compound http://rdf.rhea-db.org/Compound_16441; rh:chebi""}]"	"[{""id"": ""RHEA:63817"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63817"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-042_af36787993a0	RHEA:63817	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63817		"[{""reference_id"": ""RHEA:63817"", ""source_assertion"": ""RHEA:63817 assigns CHEBI:456215 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63817 rh:products http://rdf.rhea-db.org/63816_R; http://rdf.rhea-db.org/63816_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63816_compound_2590; rh:compound http://rdf.rhea-db.org/Compound_2590; rh:chebi""}]"	"[{""id"": ""RHEA:63817"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63817"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-043_405b902f8904	RHEA:63817	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63817		"[{""reference_id"": ""RHEA:63817"", ""source_assertion"": ""RHEA:63817 assigns CHEBI:33019 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63817 rh:products http://rdf.rhea-db.org/63816_R; http://rdf.rhea-db.org/63816_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63816_compound_2106; rh:compound http://rdf.rhea-db.org/Compound_2106; rh:chebi""}]"	"[{""id"": ""RHEA:63817"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63817"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-044_a39123e83778	RHEA:63817	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63817		"[{""reference_id"": ""RHEA:63817"", ""source_assertion"": ""RHEA:63817 assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63817 rh:products http://rdf.rhea-db.org/63816_R; http://rdf.rhea-db.org/63816_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63816_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:63817"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63817"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-045_1c8e8d840142	CHEBI:149592	pathwaymech:consumes	RHEA:64025	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:64025		"[{""reference_id"": ""RHEA:64025"", ""source_assertion"": ""RHEA:64025 assigns CHEBI:149592 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/64025 rh:substrates http://rdf.rhea-db.org/64024_L; http://rdf.rhea-db.org/64024_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_64024_compound_16440; rh:compound http://rdf.rhea-db.org/Compound_16440; rh:chebi""}]"	"[{""id"": ""RHEA:64025"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 64025"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-046_b4f1da2d33ad	RHEA-COMP:15941	pathwaymech:consumes	RHEA:64025	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:64025	This is a whole generic aryl-carrier state, not free phosphopantetheine or an exact AsbD sequence. Chemical class coefficients do not specify enzyme assembly stoichiometry.	"[{""reference_id"": ""RHEA:64025"", ""source_assertion"": ""RHEA:64025 assigns RHEA-COMP:15941 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/64025 rh:substrates http://rdf.rhea-db.org/64024_L; http://rdf.rhea-db.org/64024_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_64024_compound_15941; rh:compound http://rdf.rhea-db.org/Compound_15941; rh:name and rh:reactivePart""}]"	"[{""id"": ""RHEA:64025"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 64025"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-047_8d192ec4caf2	RHEA:64025	pathwaymech:produces	CHEBI:149594	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:64025	The issued native/ChEBI intermediate does not specify absolute citrate-derived stereochemistry. The graph preserves that class and does not assert racemic physiology or acceptance of all stereoisomers.	"[{""reference_id"": ""RHEA:64025"", ""source_assertion"": ""RHEA:64025 assigns CHEBI:149594 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/64025 rh:products http://rdf.rhea-db.org/64024_R; http://rdf.rhea-db.org/64024_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_64024_compound_16441; rh:compound http://rdf.rhea-db.org/Compound_16441; rh:chebi""}]"	"[{""id"": ""RHEA:64025"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 64025"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-048_3b02a63fa596	RHEA:64025	pathwaymech:produces	RHEA-COMP:15903	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:64025	This is a whole generic aryl-carrier state, not free phosphopantetheine or an exact AsbD sequence. Chemical class coefficients do not specify enzyme assembly stoichiometry.	"[{""reference_id"": ""RHEA:64025"", ""source_assertion"": ""RHEA:64025 assigns RHEA-COMP:15903 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/64025 rh:products http://rdf.rhea-db.org/64024_R; http://rdf.rhea-db.org/64024_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_64024_compound_15903; rh:compound http://rdf.rhea-db.org/Compound_15903; rh:name and rh:reactivePart""}]"	"[{""id"": ""RHEA:64025"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 64025"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-049_cbc0b02bf525	RHEA:64025	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:64025		"[{""reference_id"": ""RHEA:64025"", ""source_assertion"": ""RHEA:64025 assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/64025 rh:products http://rdf.rhea-db.org/64024_R; http://rdf.rhea-db.org/64024_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_64024_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:64025"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 64025"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-050_5fc4e7972842	CHEBI:149594	pathwaymech:consumes	MetaCyc:RXN-10679	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:149594|MetaCyc:CPD-11481|MetaCyc:RXN-10679	The authentic native reaction and CPD-9985 product are selected. Native and ChEBI:142778 have equal formula/charge but different spermidine-arm connectivity; no exact equation or product equivalence to RHEA:63821 is asserted. Its independently specified carrier side supports the holo output only. The issued native/ChEBI intermediate does not specify absolute citrate-derived stereochemistry. The graph preserves that class and does not assert racemic physiology or acceptance of all stereoisomers.	"[{""reference_id"": ""MetaCyc:RXN-10679"", ""source_assertion"": ""The native terminal equation places CPD-11481 on its left side with unit coefficient and physiological left-to-right direction."", ""source_locator"": ""Reaction[@frameid=\""RXN-10679\""]/left/*[@frameid=\""CPD-11481\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-11481"", ""source_assertion"": ""The native compound supplies its own InChI, formula C27H48N6O8 and charge +2; the native reaction does not supply a ChEBI identifier."", ""source_locator"": ""Compound[@frameid=\""CPD-11481\""]/inchi; cml/molecule""}, {""reference_id"": ""CHEBI:149594"", ""source_assertion"": ""The independently issued chemical has formula C27H48N6O8, charge +2 and the same InChI as the native terminal substrate. This bridge is checked independently of the rejected terminal product mapping."", ""source_locator"": ""statements[subject=CHEBI:149594,predicate=chemrof:inchi_string|chemrof:generalized_empirical_formula|chemrof:charge]""}]"	"[{""id"": ""CHEBI:149594"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; digest covers complete uncompressed Semantic SQL database"", ""title"": ""ChEBI terminal substrate structural identity"", ""url"": ""https://ftp.ebi.ac.uk/pub/databases/chebi/ontology/""}, {""id"": ""MetaCyc:CPD-11481"", ""source_sha256"": ""f0411076122880dfc4500e6d649f27e0f36b5cf4f9bf1f5612cb69751bda3c4d"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native CPD-11481"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-11481""}, {""id"": ""MetaCyc:RXN-10679"", ""source_sha256"": ""8be52d7f87ddb9b1371436d745bb5266519b7e9d1c8ec0f160477465f0832ba5"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-10679"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10679""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-051_f08b52b511df	RHEA-COMP:15941	pathwaymech:consumes	MetaCyc:RXN-10679	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-10679|RHEA:63821	The authentic native reaction and CPD-9985 product are selected. Native and ChEBI:142778 have equal formula/charge but different spermidine-arm connectivity; no exact equation or product equivalence to RHEA:63821 is asserted. Its independently specified carrier side supports the holo output only. This is a whole generic aryl-carrier state, not free phosphopantetheine or an exact AsbD sequence. Chemical class coefficients do not specify enzyme assembly stoichiometry.	"[{""reference_id"": ""MetaCyc:RXN-10679"", ""source_assertion"": ""The native terminal equation places 34-DHB-AsbD-Proteins on its left side with unit coefficient and physiological left-to-right direction."", ""source_locator"": ""Reaction[@frameid=\""RXN-10679\""]/left/*[@frameid=\""34-DHB-AsbD-Proteins\""]; reaction-direction""}, {""reference_id"": ""RHEA:63821"", ""source_assertion"": ""The compared current terminal reaction explicitly assigns RHEA-COMP:15941 to its substrates; this carrier assertion is retained independently of its rejected ChEBI product connectivity."", ""source_locator"": ""http://rdf.rhea-db.org/63821 rh:substrates http://rdf.rhea-db.org/63820_L; http://rdf.rhea-db.org/63820_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63820_compound_15941; rh:compound http://rdf.rhea-db.org/Compound_15941""}]"	"[{""id"": ""MetaCyc:RXN-10679"", ""source_sha256"": ""8be52d7f87ddb9b1371436d745bb5266519b7e9d1c8ec0f160477465f0832ba5"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-10679"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10679""}, {""id"": ""RHEA:63821"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF; conflicting small-molecule product not selected"", ""title"": ""Rhea terminal reaction, compared carrier facts only"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-052_0f0e46c8f502	MetaCyc:RXN-10679	pathwaymech:produces	MetaCyc:CPD-9985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:142778|MetaCyc:CPD-9985|MetaCyc:RXN-10679|PMID:22408253	The authentic native reaction and CPD-9985 product are selected. Native and ChEBI:142778 have equal formula/charge but different spermidine-arm connectivity; no exact equation or product equivalence to RHEA:63821 is asserted. Its independently specified carrier side supports the holo output only.	"[{""reference_id"": ""MetaCyc:RXN-10679"", ""source_assertion"": ""The native terminal equation places CPD-9985 on its right side with unit coefficient and physiological left-to-right direction."", ""source_locator"": ""Reaction[@frameid=\""RXN-10679\""]/right/*[@frameid=\""CPD-9985\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-9985"", ""source_assertion"": ""The native InChI connects each aromatic amide to the central amine through three carbons and each citrate amide through four. Formula C34H51N6O11 and charge +1 alone do not distinguish the conflicting constitutional isomer."", ""source_locator"": ""Compound[@frameid=\""CPD-9985\""]/inchi; cml/molecule/@formalCharge; cml/molecule/formula""}, {""reference_id"": ""PMID:22408253"", ""source_assertion"": ""Figure 1A/C depicts the native three-carbon aromatic-amide arms and four-carbon citrate-amide arms."", ""source_locator"": ""PMC3346087 Figure 1A and 1C""}, {""reference_id"": ""CHEBI:142778"", ""source_assertion"": ""The inspected ChEBI InChI instead has four-carbon aromatic-amide and three-carbon citrate-amide arms. This conflicting structure is not the product selected here."", ""source_locator"": ""Native InChI field, connectivity layer /c""}]"	"[{""id"": ""CHEBI:142778"", ""source_sha256"": ""3055415ebba0339caa9d2a28754ec9b75313b17a7659337fa651304e61774cd8"", ""source_version"": ""Original ChEBI HTML retrieved 2026-10-11; structure agrees with inspected ChEBI 255, but conflicts with native product connectivity"", ""title"": ""ChEBI petrobactin structure compared and rejected for this terminal product"", ""url"": ""https://www.ebi.ac.uk/chebi/CHEBI:142778""}, {""id"": ""MetaCyc:CPD-9985"", ""source_sha256"": ""ee71ebdbcea1360f1be11cdbfe84102a11a4dbddaaff57af68ff71fcfba1cfd3"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native CPD-9985"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-9985""}, {""id"": ""MetaCyc:RXN-10679"", ""source_sha256"": ""8be52d7f87ddb9b1371436d745bb5266519b7e9d1c8ec0f160477465f0832ba5"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-10679"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10679""}, {""id"": ""PMID:22408253"", ""source_sha256"": ""7ae61fa9d99e34932566cddd2541d93b9cab886eb3d8ce5d21e73e8eebdebfa8"", ""source_version"": ""Original full article in PMC HTML retrieved 2026-10-11"", ""title"": ""Functional and Structural Analysis of the Siderophore Synthetase AsbB through Reconstitution of the Petrobactin Biosynthetic Pathway from Bacillus anthracis"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3346087/""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-053_a999323690aa	MetaCyc:RXN-10679	pathwaymech:produces	RHEA-COMP:15903	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Aryl-Carrier-Proteins|MetaCyc:RXN-10679|PMID:22408253|RHEA:63821	The authentic native reaction and CPD-9985 product are selected. Native and ChEBI:142778 have equal formula/charge but different spermidine-arm connectivity; no exact equation or product equivalence to RHEA:63821 is asserted. Its independently specified carrier side supports the holo output only. This is a whole generic aryl-carrier state, not free phosphopantetheine or an exact AsbD sequence. Chemical class coefficients do not specify enzyme assembly stoichiometry.	"[{""reference_id"": ""MetaCyc:RXN-10679"", ""source_assertion"": ""The native terminal equation places Aryl-Carrier-Proteins on its right side with unit coefficient and physiological left-to-right direction."", ""source_locator"": ""Reaction[@frameid=\""RXN-10679\""]/right/*[@frameid=\""Aryl-Carrier-Proteins\""]; reaction-direction""}, {""reference_id"": ""RHEA:63821"", ""source_assertion"": ""The compared current terminal reaction explicitly assigns RHEA-COMP:15903 to its products; this carrier assertion is retained independently of its rejected ChEBI product connectivity."", ""source_locator"": ""http://rdf.rhea-db.org/63821 rh:products http://rdf.rhea-db.org/63820_R; http://rdf.rhea-db.org/63820_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63820_compound_15903; rh:compound http://rdf.rhea-db.org/Compound_15903""}, {""reference_id"": ""MetaCyc:Aryl-Carrier-Proteins"", ""source_assertion"": ""The native output is the broader aryl-carrier protein class; it is not asserted identical to the narrower Rhea holo state."", ""source_locator"": ""Protein[@frameid=\""Aryl-Carrier-Proteins\""]/parent; common-name""}, {""reference_id"": ""PMID:22408253"", ""source_assertion"": ""Figure 1C depicts release of AsbD-SH after the terminal aromatic transfer, supporting the unloaded phosphopantetheine-bearing carrier state."", ""source_locator"": ""PMC3346087 Figure 1C, terminal AsbE arrow""}]"	"[{""id"": ""MetaCyc:Aryl-Carrier-Proteins"", ""source_sha256"": ""9195b7a331b7e580eba86480bd26dcff44970affcb9db0b01198d4cd12ba84fa"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native Aryl-Carrier-Proteins"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Aryl-Carrier-Proteins""}, {""id"": ""MetaCyc:RXN-10679"", ""source_sha256"": ""8be52d7f87ddb9b1371436d745bb5266519b7e9d1c8ec0f160477465f0832ba5"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-10679"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10679""}, {""id"": ""PMID:22408253"", ""source_sha256"": ""7ae61fa9d99e34932566cddd2541d93b9cab886eb3d8ce5d21e73e8eebdebfa8"", ""source_version"": ""Original full article in PMC HTML retrieved 2026-10-11"", ""title"": ""Functional and Structural Analysis of the Siderophore Synthetase AsbB through Reconstitution of the Petrobactin Biosynthetic Pathway from Bacillus anthracis"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3346087/""}, {""id"": ""RHEA:63821"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF; conflicting small-molecule product not selected"", ""title"": ""Rhea terminal reaction, compared carrier facts only"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-054_43c78fcd1119	MetaCyc:RXN-10679	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-10679	The authentic native reaction and CPD-9985 product are selected. Native and ChEBI:142778 have equal formula/charge but different spermidine-arm connectivity; no exact equation or product equivalence to RHEA:63821 is asserted. Its independently specified carrier side supports the holo output only.	"[{""reference_id"": ""MetaCyc:RXN-10679"", ""source_assertion"": ""The native terminal equation places PROTON on its right side with unit coefficient and physiological left-to-right direction."", ""source_locator"": ""Reaction[@frameid=\""RXN-10679\""]/right/*[@frameid=\""PROTON\""]; reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-10679"", ""source_sha256"": ""8be52d7f87ddb9b1371436d745bb5266519b7e9d1c8ec0f160477465f0832ba5"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-10679"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10679""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-055_3c275ce2aaf0	MetaCyc:CPLX-7874	pathwaymech:catalyzes	RHEA:24849	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7874|PMID:18955706	The native species-level complex is applied to the experimentally sourced Sterne AsbF dimer. Exact tagged constructs are not equated to the unmodified gene product.	"[{""reference_id"": ""MetaCyc:CPLX-7874"", ""source_assertion"": ""The native dimer catalyzes DHSHIKIMATE-DEHYDRO-RXN and contains two copies of MONOMER-14940."", ""source_locator"": ""Protein[@frameid=\""CPLX-7874\""]/catalyzes; component/Protein; component/coefficient""}, {""reference_id"": ""PMID:18955706"", ""source_assertion"": ""Purified AsbF converted 3-dehydroshikimate to 3,4-dihydroxybenzoate; structural and solution measurements support a dimer."", ""source_locator"": ""PMC2579390 Results/sec3/p[2]; sec5/p[2]""}]"	"[{""id"": ""MetaCyc:CPLX-7874"", ""source_sha256"": ""5896a9ab1cae231197f76ba3da527cf34b98958c5e09a53502371842ac4bb3a8"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native CPLX-7874"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7874""}, {""id"": ""PMID:18955706"", ""source_sha256"": ""7c083d2a8097c0be99f1b2a219b02b7171b60defb8e67abd65ffe4c71e6a4b40"", ""source_version"": ""Original full article in PMC HTML retrieved 2026-10-11"", ""title"": ""Structural and functional analysis of AsbF: Origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2579390/""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-056_76984391bd5d	NCBIProtein:AAT54155.1	pathwaymech:enables	RHEA:62469	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAT54155.1|PMID:17346033|UniProtKB:Q81RQ7	AsbC gene-product role; the original Sterne translation equals the current reviewed sequence. The two native component transformations are retained without additionally counting the overlapping Rhea net reaction. Exact tagged constructs and a fixed oligomeric state are not established here.	"[{""reference_id"": ""NCBIProtein:AAT54155.1"", ""source_assertion"": ""AAT54155.1 is the original versioned Sterne gene product for the selected AsbC role; its source feature binds strain Sterne and taxon:260799. Native identity does not assert exact engineered-construct equality."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""AAT54155.1\""]/GBSeq_feature-table/GBFeature[GBFeature_key=\""source\""]/GBFeature_quals; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q81RQ7"", ""source_assertion"": ""The reviewed species-level AsbC entry assigns the corresponding biochemical activity with ECO:0000269 citations. Its source annotation is used with the separately checked Sterne sequence correspondence, not as exact tagged-construct identity."", ""source_locator"": ""/comments/2/reaction/name; reactionCrossReferences; evidences""}, {""reference_id"": ""PMID:17346033"", ""source_assertion"": ""The inspected abstract reports AsbC adenylation of 3,4-dihydroxybenzoate and subsequent transfer to AsbD. The complete original paper was not available."", ""source_locator"": ""resultList/result[id=\""17346033\""]/abstractText""}]"	"[{""id"": ""NCBIProtein:AAT54155.1"", ""source_sha256"": ""e67b0c1bae9128c5c1688e1d358003f1bac3ff5b2a0e03685d4ebe29ca72bc20"", ""source_version"": ""Original NCBI GenPept six-entry batch retrieved 2026-10-11; digest covers complete unmodified batch"", ""title"": ""AMP-binding protein [Bacillus anthracis str. Sterne]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAT54153.1,AAT54154.1,AAT54155.1,AAT54156.1,AAT54157.1,AAT54158.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:17346033"", ""source_sha256"": ""26b83f8176ad47257f0d82855e9dde65ac3c358b57f754a40358919808a5a245"", ""source_version"": ""Europe PMC original indexed abstract only, retrieved 2026-10-11; original full article unavailable through inspected routes"", ""title"": ""Characterization and analysis of early enzymes for petrobactin biosynthesis in Bacillus anthracis."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17346033&format=json&resultType=core""}, {""id"": ""UniProtKB:Q81RQ7"", ""source_sha256"": ""0ea212f8bdf3310a20e8bd99e72557909506af2304234a5ddad9dd0abcddae09"", ""source_version"": ""UniProt 2026_03; complete original reviewed entry retrieved 2026-10-11"", ""title"": ""UniProtKB reviewed Q81RQ7"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q81RQ7.json""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-057_d1f01e78b729	NCBIProtein:AAT54155.1	pathwaymech:enables	RHEA:62477	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAT54155.1|PMID:17346033|UniProtKB:Q81RQ7	AsbC gene-product role; the original Sterne translation equals the current reviewed sequence. The two native component transformations are retained without additionally counting the overlapping Rhea net reaction. Exact tagged constructs and a fixed oligomeric state are not established here.	"[{""reference_id"": ""NCBIProtein:AAT54155.1"", ""source_assertion"": ""AAT54155.1 is the original versioned Sterne gene product for the selected AsbC role; its source feature binds strain Sterne and taxon:260799. Native identity does not assert exact engineered-construct equality."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""AAT54155.1\""]/GBSeq_feature-table/GBFeature[GBFeature_key=\""source\""]/GBFeature_quals; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q81RQ7"", ""source_assertion"": ""The reviewed species-level AsbC entry assigns the corresponding biochemical activity with ECO:0000269 citations. Its source annotation is used with the separately checked Sterne sequence correspondence, not as exact tagged-construct identity."", ""source_locator"": ""/comments/3/reaction/name; reactionCrossReferences; evidences""}, {""reference_id"": ""PMID:17346033"", ""source_assertion"": ""The inspected abstract reports AsbC adenylation of 3,4-dihydroxybenzoate and subsequent transfer to AsbD. The complete original paper was not available."", ""source_locator"": ""resultList/result[id=\""17346033\""]/abstractText""}]"	"[{""id"": ""NCBIProtein:AAT54155.1"", ""source_sha256"": ""e67b0c1bae9128c5c1688e1d358003f1bac3ff5b2a0e03685d4ebe29ca72bc20"", ""source_version"": ""Original NCBI GenPept six-entry batch retrieved 2026-10-11; digest covers complete unmodified batch"", ""title"": ""AMP-binding protein [Bacillus anthracis str. Sterne]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAT54153.1,AAT54154.1,AAT54155.1,AAT54156.1,AAT54157.1,AAT54158.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:17346033"", ""source_sha256"": ""26b83f8176ad47257f0d82855e9dde65ac3c358b57f754a40358919808a5a245"", ""source_version"": ""Europe PMC original indexed abstract only, retrieved 2026-10-11; original full article unavailable through inspected routes"", ""title"": ""Characterization and analysis of early enzymes for petrobactin biosynthesis in Bacillus anthracis."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17346033&format=json&resultType=core""}, {""id"": ""UniProtKB:Q81RQ7"", ""source_sha256"": ""0ea212f8bdf3310a20e8bd99e72557909506af2304234a5ddad9dd0abcddae09"", ""source_version"": ""UniProt 2026_03; complete original reviewed entry retrieved 2026-10-11"", ""title"": ""UniProtKB reviewed Q81RQ7"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q81RQ7.json""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-058_137c7b35a2b3	NCBIProtein:AAT54153.1	pathwaymech:enables	RHEA:63809	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAT54153.1|PMID:22408253|UniProtKB:Q81RQ9	AsbA gene-product activity does not assert monomer sufficiency. The original Sterne translation equals the current reviewed sequence. Magnesium-dependent assay context is retained without an independently established metal-binding cofactor relation. AsbB can partly substitute in vitro, so this edge does not assert universal AsbA indispensability.	"[{""reference_id"": ""NCBIProtein:AAT54153.1"", ""source_assertion"": ""AAT54153.1 is the original versioned Sterne gene product for the selected AsbA role; its source feature binds strain Sterne and taxon:260799. Native identity does not assert exact engineered-construct equality."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""AAT54153.1\""]/GBSeq_feature-table/GBFeature[GBFeature_key=\""source\""]/GBFeature_quals; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q81RQ9"", ""source_assertion"": ""The reviewed species-level AsbA entry assigns the corresponding biochemical activity with ECO:0000269 citations. Its source annotation is used with the separately checked Sterne sequence correspondence, not as exact tagged-construct identity."", ""source_locator"": ""/comments/1/reaction/name; reactionCrossReferences; evidences""}, {""reference_id"": ""PMID:22408253"", ""source_assertion"": ""The Sterne-derived AsbA preparation supplied the first citrate-spermidine ligation; later AsbE transfer branches are supported in the same study."", ""source_locator"": ""PMC3346087 Results/sec21/p[1]; sec22/p[3]; Figure 1C""}]"	"[{""id"": ""NCBIProtein:AAT54153.1"", ""source_sha256"": ""e67b0c1bae9128c5c1688e1d358003f1bac3ff5b2a0e03685d4ebe29ca72bc20"", ""source_version"": ""Original NCBI GenPept six-entry batch retrieved 2026-10-11; digest covers complete unmodified batch"", ""title"": ""siderophore biosynthesis protein, putative [Bacillus anthracis str. Sterne]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAT54153.1,AAT54154.1,AAT54155.1,AAT54156.1,AAT54157.1,AAT54158.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:22408253"", ""source_sha256"": ""7ae61fa9d99e34932566cddd2541d93b9cab886eb3d8ce5d21e73e8eebdebfa8"", ""source_version"": ""Original full article in PMC HTML retrieved 2026-10-11"", ""title"": ""Functional and Structural Analysis of the Siderophore Synthetase AsbB through Reconstitution of the Petrobactin Biosynthetic Pathway from Bacillus anthracis"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3346087/""}, {""id"": ""UniProtKB:Q81RQ9"", ""source_sha256"": ""7a8c98cdc94e908bdd22899a8a7ee1cab6c6eed90516765b250ab9cbdf13d554"", ""source_version"": ""UniProt 2026_03; complete original reviewed entry retrieved 2026-10-11"", ""title"": ""UniProtKB reviewed Q81RQ9"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q81RQ9.json""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-059_a812eba03a89	NCBIProtein:AAT54154.1	pathwaymech:enables	RHEA:63813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAT54154.1|PMID:22408253|UniProtKB:Q81RQ8	The versioned Sterne AsbB translation is 610 residues; current reviewed Q81RQ8 has two additional N-terminal residues. The primary supports a dimeric preparation,; its gene-product enables relation does not establish monomer sufficiency. Exact recombinant construct equality is not established.	"[{""reference_id"": ""NCBIProtein:AAT54154.1"", ""source_assertion"": ""AAT54154.1 is the original versioned Sterne gene product for the selected AsbB role; its source feature binds strain Sterne and taxon:260799. Native identity does not assert exact engineered-construct equality."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""AAT54154.1\""]/GBSeq_feature-table/GBFeature[GBFeature_key=\""source\""]/GBFeature_quals; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q81RQ8"", ""source_assertion"": ""The reviewed species-level AsbB entry assigns the corresponding biochemical activity with ECO:0000269 citations. Its source annotation is used with the separately checked Sterne sequence correspondence, not as exact tagged-construct identity."", ""source_locator"": ""/comments/1/reaction/name; reactionCrossReferences; evidences""}, {""reference_id"": ""PMID:22408253"", ""source_assertion"": ""Sterne AsbB accepts the two citryl intermediates. Its homodimer is supported by crystallography and size exclusion."", ""source_locator"": ""PMC3346087 Results/sec22/p[2-3]; sec23/p[3]; sec25/p[1]; Figure 1C""}]"	"[{""id"": ""NCBIProtein:AAT54154.1"", ""source_sha256"": ""e67b0c1bae9128c5c1688e1d358003f1bac3ff5b2a0e03685d4ebe29ca72bc20"", ""source_version"": ""Original NCBI GenPept six-entry batch retrieved 2026-10-11; digest covers complete unmodified batch"", ""title"": ""siderophore biosynthesis protein, putative [Bacillus anthracis str. Sterne]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAT54153.1,AAT54154.1,AAT54155.1,AAT54156.1,AAT54157.1,AAT54158.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:22408253"", ""source_sha256"": ""7ae61fa9d99e34932566cddd2541d93b9cab886eb3d8ce5d21e73e8eebdebfa8"", ""source_version"": ""Original full article in PMC HTML retrieved 2026-10-11"", ""title"": ""Functional and Structural Analysis of the Siderophore Synthetase AsbB through Reconstitution of the Petrobactin Biosynthetic Pathway from Bacillus anthracis"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3346087/""}, {""id"": ""UniProtKB:Q81RQ8"", ""source_sha256"": ""04c3f98d6f0acdcc678d7a4a80e63107562ce0d897d0a7686543e90c8fa40267"", ""source_version"": ""UniProt 2026_03; complete original reviewed entry retrieved 2026-10-11"", ""title"": ""UniProtKB reviewed Q81RQ8"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q81RQ8.json""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-060_3ee67df2af86	NCBIProtein:AAT54157.1	pathwaymech:enables	RHEA:64029	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAT54157.1|PMID:22408253|UniProtKB:Q81RQ5	The versioned Sterne AsbE translation is 331 residues; current reviewed Q81RQ5 matches its suffix after four residues. The role is grounded in the Sterne source and primary functional assignment, not full-sequence equality to the current annotation. Its fixed assembly is unresolved.	"[{""reference_id"": ""NCBIProtein:AAT54157.1"", ""source_assertion"": ""AAT54157.1 is the original versioned Sterne gene product for the selected AsbE role; its source feature binds strain Sterne and taxon:260799. Native identity does not assert exact engineered-construct equality."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""AAT54157.1\""]/GBSeq_feature-table/GBFeature[GBFeature_key=\""source\""]/GBFeature_quals; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q81RQ5"", ""source_assertion"": ""The reviewed species-level AsbE entry assigns the corresponding biochemical activity with ECO:0000269 citations. Its source annotation is used with the separately checked Sterne sequence correspondence, not as exact tagged-construct identity."", ""source_locator"": ""/comments/1/reaction/name; reactionCrossReferences; evidences""}, {""reference_id"": ""PMID:22408253"", ""source_assertion"": ""Sterne-derived AsbC/D/E preparations supported both aromatic-transfer branches and terminal product formation."", ""source_locator"": ""PMC3346087 Results/sec21/p[1]; sec28/p[2-3]; Figure 1C and Figure 7""}]"	"[{""id"": ""NCBIProtein:AAT54157.1"", ""source_sha256"": ""e67b0c1bae9128c5c1688e1d358003f1bac3ff5b2a0e03685d4ebe29ca72bc20"", ""source_version"": ""Original NCBI GenPept six-entry batch retrieved 2026-10-11; digest covers complete unmodified batch"", ""title"": ""hypothetical protein BAS1842 [Bacillus anthracis str. Sterne]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAT54153.1,AAT54154.1,AAT54155.1,AAT54156.1,AAT54157.1,AAT54158.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:22408253"", ""source_sha256"": ""7ae61fa9d99e34932566cddd2541d93b9cab886eb3d8ce5d21e73e8eebdebfa8"", ""source_version"": ""Original full article in PMC HTML retrieved 2026-10-11"", ""title"": ""Functional and Structural Analysis of the Siderophore Synthetase AsbB through Reconstitution of the Petrobactin Biosynthetic Pathway from Bacillus anthracis"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3346087/""}, {""id"": ""UniProtKB:Q81RQ5"", ""source_sha256"": ""df66c3ffa2d5d566a32ec151c60607d918adb7f60555123ad19e2f5326d219c6"", ""source_version"": ""UniProt 2026_03; complete original reviewed entry retrieved 2026-10-11"", ""title"": ""UniProtKB reviewed Q81RQ5"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q81RQ5.json""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-061_33b730b56463	NCBIProtein:AAT54154.1	pathwaymech:enables	RHEA:63817	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAT54154.1|PMID:22408253|UniProtKB:Q81RQ8	The versioned Sterne AsbB translation is 610 residues; current reviewed Q81RQ8 has two additional N-terminal residues. The primary supports a dimeric preparation,; its gene-product enables relation does not establish monomer sufficiency. Exact recombinant construct equality is not established.	"[{""reference_id"": ""NCBIProtein:AAT54154.1"", ""source_assertion"": ""AAT54154.1 is the original versioned Sterne gene product for the selected AsbB role; its source feature binds strain Sterne and taxon:260799. Native identity does not assert exact engineered-construct equality."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""AAT54154.1\""]/GBSeq_feature-table/GBFeature[GBFeature_key=\""source\""]/GBFeature_quals; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q81RQ8"", ""source_assertion"": ""The reviewed species-level AsbB entry assigns the corresponding biochemical activity with ECO:0000269 citations. Its source annotation is used with the separately checked Sterne sequence correspondence, not as exact tagged-construct identity."", ""source_locator"": ""/comments/2/reaction/name; reactionCrossReferences; evidences""}, {""reference_id"": ""PMID:22408253"", ""source_assertion"": ""Sterne AsbB accepts the two citryl intermediates. Its homodimer is supported by crystallography and size exclusion."", ""source_locator"": ""PMC3346087 Results/sec22/p[2-3]; sec23/p[3]; sec25/p[1]; Figure 1C""}]"	"[{""id"": ""NCBIProtein:AAT54154.1"", ""source_sha256"": ""e67b0c1bae9128c5c1688e1d358003f1bac3ff5b2a0e03685d4ebe29ca72bc20"", ""source_version"": ""Original NCBI GenPept six-entry batch retrieved 2026-10-11; digest covers complete unmodified batch"", ""title"": ""siderophore biosynthesis protein, putative [Bacillus anthracis str. Sterne]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAT54153.1,AAT54154.1,AAT54155.1,AAT54156.1,AAT54157.1,AAT54158.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:22408253"", ""source_sha256"": ""7ae61fa9d99e34932566cddd2541d93b9cab886eb3d8ce5d21e73e8eebdebfa8"", ""source_version"": ""Original full article in PMC HTML retrieved 2026-10-11"", ""title"": ""Functional and Structural Analysis of the Siderophore Synthetase AsbB through Reconstitution of the Petrobactin Biosynthetic Pathway from Bacillus anthracis"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3346087/""}, {""id"": ""UniProtKB:Q81RQ8"", ""source_sha256"": ""04c3f98d6f0acdcc678d7a4a80e63107562ce0d897d0a7686543e90c8fa40267"", ""source_version"": ""UniProt 2026_03; complete original reviewed entry retrieved 2026-10-11"", ""title"": ""UniProtKB reviewed Q81RQ8"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q81RQ8.json""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-062_0d6f248bed65	NCBIProtein:AAT54157.1	pathwaymech:enables	RHEA:64025	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAT54157.1|PMID:22408253|UniProtKB:Q81RQ5	The versioned Sterne AsbE translation is 331 residues; current reviewed Q81RQ5 matches its suffix after four residues. The role is grounded in the Sterne source and primary functional assignment, not full-sequence equality to the current annotation. Its fixed assembly is unresolved. The bis(spermidine) branch uses the current database single-transfer step; the primary observed final product and proposed successive transfers because the monoaryl intermediate did not accumulate.	"[{""reference_id"": ""NCBIProtein:AAT54157.1"", ""source_assertion"": ""AAT54157.1 is the original versioned Sterne gene product for the selected AsbE role; its source feature binds strain Sterne and taxon:260799. Native identity does not assert exact engineered-construct equality."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""AAT54157.1\""]/GBSeq_feature-table/GBFeature[GBFeature_key=\""source\""]/GBFeature_quals; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q81RQ5"", ""source_assertion"": ""The reviewed species-level AsbE entry assigns the corresponding biochemical activity with ECO:0000269 citations. Its source annotation is used with the separately checked Sterne sequence correspondence, not as exact tagged-construct identity."", ""source_locator"": ""/comments/2/reaction/name; reactionCrossReferences; evidences""}, {""reference_id"": ""PMID:22408253"", ""source_assertion"": ""Sterne-derived AsbC/D/E preparations supported both aromatic-transfer branches and terminal product formation."", ""source_locator"": ""PMC3346087 Results/sec21/p[1]; sec28/p[2-3]; Figure 1C and Figure 7""}]"	"[{""id"": ""NCBIProtein:AAT54157.1"", ""source_sha256"": ""e67b0c1bae9128c5c1688e1d358003f1bac3ff5b2a0e03685d4ebe29ca72bc20"", ""source_version"": ""Original NCBI GenPept six-entry batch retrieved 2026-10-11; digest covers complete unmodified batch"", ""title"": ""hypothetical protein BAS1842 [Bacillus anthracis str. Sterne]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAT54153.1,AAT54154.1,AAT54155.1,AAT54156.1,AAT54157.1,AAT54158.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:22408253"", ""source_sha256"": ""7ae61fa9d99e34932566cddd2541d93b9cab886eb3d8ce5d21e73e8eebdebfa8"", ""source_version"": ""Original full article in PMC HTML retrieved 2026-10-11"", ""title"": ""Functional and Structural Analysis of the Siderophore Synthetase AsbB through Reconstitution of the Petrobactin Biosynthetic Pathway from Bacillus anthracis"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3346087/""}, {""id"": ""UniProtKB:Q81RQ5"", ""source_sha256"": ""df66c3ffa2d5d566a32ec151c60607d918adb7f60555123ad19e2f5326d219c6"", ""source_version"": ""UniProt 2026_03; complete original reviewed entry retrieved 2026-10-11"", ""title"": ""UniProtKB reviewed Q81RQ5"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q81RQ5.json""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-063_043063e1deea	NCBIProtein:AAT54157.1	pathwaymech:enables	MetaCyc:RXN-10679	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAT54157.1|PMID:22408253|UniProtKB:Q81RQ5	The versioned Sterne AsbE translation is 331 residues; current reviewed Q81RQ5 matches its suffix after four residues. The role is grounded in the Sterne source and primary functional assignment, not full-sequence equality to the current annotation. Its fixed assembly is unresolved. The authentic native terminal product is retained despite the current ChEBI connectivity conflict.	"[{""reference_id"": ""NCBIProtein:AAT54157.1"", ""source_assertion"": ""AAT54157.1 is the original versioned Sterne gene product for the selected AsbE role; its source feature binds strain Sterne and taxon:260799. Native identity does not assert exact engineered-construct equality."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""AAT54157.1\""]/GBSeq_feature-table/GBFeature[GBFeature_key=\""source\""]/GBFeature_quals; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q81RQ5"", ""source_assertion"": ""The reviewed species-level AsbE entry assigns the corresponding biochemical activity with ECO:0000269 citations. Its source annotation is used with the separately checked Sterne sequence correspondence, not as exact tagged-construct identity."", ""source_locator"": ""/comments/3/reaction/name; reactionCrossReferences; evidences""}, {""reference_id"": ""PMID:22408253"", ""source_assertion"": ""Sterne-derived AsbC/D/E preparations supported both aromatic-transfer branches and terminal product formation."", ""source_locator"": ""PMC3346087 Results/sec21/p[1]; sec28/p[2-3]; Figure 1C and Figure 7""}]"	"[{""id"": ""NCBIProtein:AAT54157.1"", ""source_sha256"": ""e67b0c1bae9128c5c1688e1d358003f1bac3ff5b2a0e03685d4ebe29ca72bc20"", ""source_version"": ""Original NCBI GenPept six-entry batch retrieved 2026-10-11; digest covers complete unmodified batch"", ""title"": ""hypothetical protein BAS1842 [Bacillus anthracis str. Sterne]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAT54153.1,AAT54154.1,AAT54155.1,AAT54156.1,AAT54157.1,AAT54158.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:22408253"", ""source_sha256"": ""7ae61fa9d99e34932566cddd2541d93b9cab886eb3d8ce5d21e73e8eebdebfa8"", ""source_version"": ""Original full article in PMC HTML retrieved 2026-10-11"", ""title"": ""Functional and Structural Analysis of the Siderophore Synthetase AsbB through Reconstitution of the Petrobactin Biosynthetic Pathway from Bacillus anthracis"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3346087/""}, {""id"": ""UniProtKB:Q81RQ5"", ""source_sha256"": ""df66c3ffa2d5d566a32ec151c60607d918adb7f60555123ad19e2f5326d219c6"", ""source_version"": ""UniProt 2026_03; complete original reviewed entry retrieved 2026-10-11"", ""title"": ""UniProtKB reviewed Q81RQ5"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q81RQ5.json""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-064_82e97b006e95	RHEA:48405	BFO:0000050	MetaCyc:PWY-6289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6289|RHEA:48405	The original native object and current reaction are bridged by separately inspected chemical structures and carrier-class definitions; no absent native Rhea cross-reference is invented.	"[{""reference_id"": ""MetaCyc:PWY-6289"", ""source_assertion"": ""The native pathway explicitly contains RXN-19493 and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-6289\""]/reaction-list/Reaction[@frameid=\""RXN-19493\""]; reaction-layout[Reaction/@frameid=\""RXN-19493\""]/direction""}, {""reference_id"": ""RHEA:48405"", ""source_assertion"": ""Rhea master 48404 explicitly links directed reaction 48405; its independently inspected chemical sides implement the selected native transformation."", ""source_locator"": ""http://rdf.rhea-db.org/48404 rh:directionalReaction http://rdf.rhea-db.org/48405; http://rdf.rhea-db.org/48405 rh:substrates/rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6289"", ""source_sha256"": ""3fed3ca9d42aea344bd65ad211faa4dee23d3b9cd41ed50c1792804df98cfc7c"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-6289"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6289""}, {""id"": ""RHEA:48405"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 48405"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-065_ca5cc40e0ba1	RHEA:24849	BFO:0000050	MetaCyc:PWY-6289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6289|RHEA:24849	The original native object and current reaction are bridged by separately inspected chemical structures and carrier-class definitions; no absent native Rhea cross-reference is invented.	"[{""reference_id"": ""MetaCyc:PWY-6289"", ""source_assertion"": ""The native pathway explicitly contains DHSHIKIMATE-DEHYDRO-RXN and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-6289\""]/reaction-list/Reaction[@frameid=\""DHSHIKIMATE-DEHYDRO-RXN\""]; reaction-layout[Reaction/@frameid=\""DHSHIKIMATE-DEHYDRO-RXN\""]/direction""}, {""reference_id"": ""RHEA:24849"", ""source_assertion"": ""Rhea master 24848 explicitly links directed reaction 24849; its independently inspected chemical sides implement the selected native transformation."", ""source_locator"": ""http://rdf.rhea-db.org/24848 rh:directionalReaction http://rdf.rhea-db.org/24849; http://rdf.rhea-db.org/24849 rh:substrates/rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6289"", ""source_sha256"": ""3fed3ca9d42aea344bd65ad211faa4dee23d3b9cd41ed50c1792804df98cfc7c"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-6289"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6289""}, {""id"": ""RHEA:24849"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 24849"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-066_9f625835425c	RHEA:62469	BFO:0000050	MetaCyc:PWY-6289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6289|RHEA:62469	The original native object and current reaction are bridged by separately inspected chemical structures and carrier-class definitions; no absent native Rhea cross-reference is invented.	"[{""reference_id"": ""MetaCyc:PWY-6289"", ""source_assertion"": ""The native pathway explicitly contains RXN-10675 and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-6289\""]/reaction-list/Reaction[@frameid=\""RXN-10675\""]; reaction-layout[Reaction/@frameid=\""RXN-10675\""]/direction""}, {""reference_id"": ""RHEA:62469"", ""source_assertion"": ""Rhea master 62468 explicitly links directed reaction 62469; its independently inspected chemical sides implement the selected native transformation."", ""source_locator"": ""http://rdf.rhea-db.org/62468 rh:directionalReaction http://rdf.rhea-db.org/62469; http://rdf.rhea-db.org/62469 rh:substrates/rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6289"", ""source_sha256"": ""3fed3ca9d42aea344bd65ad211faa4dee23d3b9cd41ed50c1792804df98cfc7c"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-6289"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6289""}, {""id"": ""RHEA:62469"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62469"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-067_c480c8ee84f8	RHEA:62477	BFO:0000050	MetaCyc:PWY-6289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6289|RHEA:62477	The original native object and current reaction are bridged by separately inspected chemical structures and carrier-class definitions; no absent native Rhea cross-reference is invented.	"[{""reference_id"": ""MetaCyc:PWY-6289"", ""source_assertion"": ""The native pathway explicitly contains RXN-10676 and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-6289\""]/reaction-list/Reaction[@frameid=\""RXN-10676\""]; reaction-layout[Reaction/@frameid=\""RXN-10676\""]/direction""}, {""reference_id"": ""RHEA:62477"", ""source_assertion"": ""Rhea master 62476 explicitly links directed reaction 62477; its independently inspected chemical sides implement the selected native transformation."", ""source_locator"": ""http://rdf.rhea-db.org/62476 rh:directionalReaction http://rdf.rhea-db.org/62477; http://rdf.rhea-db.org/62477 rh:substrates/rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6289"", ""source_sha256"": ""3fed3ca9d42aea344bd65ad211faa4dee23d3b9cd41ed50c1792804df98cfc7c"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-6289"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6289""}, {""id"": ""RHEA:62477"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62477"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-068_227d1d19eb40	RHEA:63809	BFO:0000050	MetaCyc:PWY-6289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6289|RHEA:63809	The original native object and current reaction are bridged by separately inspected chemical structures and carrier-class definitions; no absent native Rhea cross-reference is invented.	"[{""reference_id"": ""MetaCyc:PWY-6289"", ""source_assertion"": ""The native pathway explicitly contains RXN-10680 and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-6289\""]/reaction-list/Reaction[@frameid=\""RXN-10680\""]; reaction-layout[Reaction/@frameid=\""RXN-10680\""]/direction""}, {""reference_id"": ""RHEA:63809"", ""source_assertion"": ""Rhea master 63808 explicitly links directed reaction 63809; its independently inspected chemical sides implement the selected native transformation."", ""source_locator"": ""http://rdf.rhea-db.org/63808 rh:directionalReaction http://rdf.rhea-db.org/63809; http://rdf.rhea-db.org/63809 rh:substrates/rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6289"", ""source_sha256"": ""3fed3ca9d42aea344bd65ad211faa4dee23d3b9cd41ed50c1792804df98cfc7c"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-6289"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6289""}, {""id"": ""RHEA:63809"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63809"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-069_2166684be562	RHEA:63813	BFO:0000050	MetaCyc:PWY-6289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6289|RHEA:63813	The original native object and current reaction are bridged by separately inspected chemical structures and carrier-class definitions; no absent native Rhea cross-reference is invented.	"[{""reference_id"": ""MetaCyc:PWY-6289"", ""source_assertion"": ""The native pathway explicitly contains RXN-10681 and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-6289\""]/reaction-list/Reaction[@frameid=\""RXN-10681\""]; reaction-layout[Reaction/@frameid=\""RXN-10681\""]/direction""}, {""reference_id"": ""RHEA:63813"", ""source_assertion"": ""Rhea master 63812 explicitly links directed reaction 63813; its independently inspected chemical sides implement the selected native transformation."", ""source_locator"": ""http://rdf.rhea-db.org/63812 rh:directionalReaction http://rdf.rhea-db.org/63813; http://rdf.rhea-db.org/63813 rh:substrates/rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6289"", ""source_sha256"": ""3fed3ca9d42aea344bd65ad211faa4dee23d3b9cd41ed50c1792804df98cfc7c"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-6289"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6289""}, {""id"": ""RHEA:63813"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63813"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-070_db6d35e7bab3	RHEA:64029	BFO:0000050	MetaCyc:PWY-6289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6289|RHEA:64029	The original native object and current reaction are bridged by separately inspected chemical structures and carrier-class definitions; no absent native Rhea cross-reference is invented.	"[{""reference_id"": ""MetaCyc:PWY-6289"", ""source_assertion"": ""The native pathway explicitly contains RXN-10677 and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-6289\""]/reaction-list/Reaction[@frameid=\""RXN-10677\""]; reaction-layout[Reaction/@frameid=\""RXN-10677\""]/direction""}, {""reference_id"": ""RHEA:64029"", ""source_assertion"": ""Rhea master 64028 explicitly links directed reaction 64029; its independently inspected chemical sides implement the selected native transformation."", ""source_locator"": ""http://rdf.rhea-db.org/64028 rh:directionalReaction http://rdf.rhea-db.org/64029; http://rdf.rhea-db.org/64029 rh:substrates/rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6289"", ""source_sha256"": ""3fed3ca9d42aea344bd65ad211faa4dee23d3b9cd41ed50c1792804df98cfc7c"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-6289"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6289""}, {""id"": ""RHEA:64029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 64029"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-071_e6ae6ef1320c	RHEA:63817	BFO:0000050	MetaCyc:PWY-6289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6289|RHEA:63817	The original native object and current reaction are bridged by separately inspected chemical structures and carrier-class definitions; no absent native Rhea cross-reference is invented.	"[{""reference_id"": ""MetaCyc:PWY-6289"", ""source_assertion"": ""The native pathway explicitly contains RXN-10678 and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-6289\""]/reaction-list/Reaction[@frameid=\""RXN-10678\""]; reaction-layout[Reaction/@frameid=\""RXN-10678\""]/direction""}, {""reference_id"": ""RHEA:63817"", ""source_assertion"": ""Rhea master 63816 explicitly links directed reaction 63817; its independently inspected chemical sides implement the selected native transformation."", ""source_locator"": ""http://rdf.rhea-db.org/63816 rh:directionalReaction http://rdf.rhea-db.org/63817; http://rdf.rhea-db.org/63817 rh:substrates/rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6289"", ""source_sha256"": ""3fed3ca9d42aea344bd65ad211faa4dee23d3b9cd41ed50c1792804df98cfc7c"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-6289"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6289""}, {""id"": ""RHEA:63817"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63817"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-072_b99a76b31474	RHEA:64025	BFO:0000050	MetaCyc:PWY-6289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6289|RHEA:64025	The original native object and current reaction are bridged by separately inspected chemical structures and carrier-class definitions; no absent native Rhea cross-reference is invented.	"[{""reference_id"": ""MetaCyc:PWY-6289"", ""source_assertion"": ""The native pathway explicitly contains RXN-10682 and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-6289\""]/reaction-list/Reaction[@frameid=\""RXN-10682\""]; reaction-layout[Reaction/@frameid=\""RXN-10682\""]/direction""}, {""reference_id"": ""RHEA:64025"", ""source_assertion"": ""Rhea master 64024 explicitly links directed reaction 64025; its independently inspected chemical sides implement the selected native transformation."", ""source_locator"": ""http://rdf.rhea-db.org/64024 rh:directionalReaction http://rdf.rhea-db.org/64025; http://rdf.rhea-db.org/64025 rh:substrates/rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6289"", ""source_sha256"": ""3fed3ca9d42aea344bd65ad211faa4dee23d3b9cd41ed50c1792804df98cfc7c"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-6289"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6289""}, {""id"": ""RHEA:64025"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 64025"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-073_77bb0e343414	MetaCyc:RXN-10679	BFO:0000050	MetaCyc:PWY-6289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6289|MetaCyc:RXN-10679	The authentic native reaction and CPD-9985 product are selected. Native and ChEBI:142778 have equal formula/charge but different spermidine-arm connectivity; no exact equation or product equivalence to RHEA:63821 is asserted. Its independently specified carrier side supports the holo output only.	"[{""reference_id"": ""MetaCyc:PWY-6289"", ""source_assertion"": ""The native pathway explicitly contains RXN-10679 and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-6289\""]/reaction-list/Reaction[@frameid=\""RXN-10679\""]; reaction-layout[Reaction/@frameid=\""RXN-10679\""]/direction""}, {""reference_id"": ""MetaCyc:RXN-10679"", ""source_assertion"": ""The authentic native reaction selects physiological left-to-right terminal transfer to CPD-9985."", ""source_locator"": ""Reaction[@frameid=\""RXN-10679\""]/reaction-direction; left; right""}]"	"[{""id"": ""MetaCyc:PWY-6289"", ""source_sha256"": ""3fed3ca9d42aea344bd65ad211faa4dee23d3b9cd41ed50c1792804df98cfc7c"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native PWY-6289"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6289""}, {""id"": ""MetaCyc:RXN-10679"", ""source_sha256"": ""8be52d7f87ddb9b1371436d745bb5266519b7e9d1c8ec0f160477465f0832ba5"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-10679"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10679""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-074_196110d2821c	NCBIProtein:AAT54153.1	BFO:0000050	NCBITaxon:260799	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAT54153.1		"[{""reference_id"": ""NCBIProtein:AAT54153.1"", ""source_assertion"": ""The source feature explicitly records strain Sterne and taxon:260799."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""AAT54153.1\""]/GBSeq_feature-table/GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}]"	"[{""id"": ""NCBIProtein:AAT54153.1"", ""source_sha256"": ""e67b0c1bae9128c5c1688e1d358003f1bac3ff5b2a0e03685d4ebe29ca72bc20"", ""source_version"": ""Original NCBI GenPept six-entry batch retrieved 2026-10-11; digest covers complete unmodified batch"", ""title"": ""siderophore biosynthesis protein, putative [Bacillus anthracis str. Sterne]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAT54153.1,AAT54154.1,AAT54155.1,AAT54156.1,AAT54157.1,AAT54158.1&rettype=gb&retmode=xml""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-075_0ce3f77f3779	NCBIProtein:AAT54154.1	BFO:0000050	NCBITaxon:260799	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAT54154.1		"[{""reference_id"": ""NCBIProtein:AAT54154.1"", ""source_assertion"": ""The source feature explicitly records strain Sterne and taxon:260799."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""AAT54154.1\""]/GBSeq_feature-table/GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}]"	"[{""id"": ""NCBIProtein:AAT54154.1"", ""source_sha256"": ""e67b0c1bae9128c5c1688e1d358003f1bac3ff5b2a0e03685d4ebe29ca72bc20"", ""source_version"": ""Original NCBI GenPept six-entry batch retrieved 2026-10-11; digest covers complete unmodified batch"", ""title"": ""siderophore biosynthesis protein, putative [Bacillus anthracis str. Sterne]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAT54153.1,AAT54154.1,AAT54155.1,AAT54156.1,AAT54157.1,AAT54158.1&rettype=gb&retmode=xml""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-076_a7c1d00e6a3e	NCBIProtein:AAT54155.1	BFO:0000050	NCBITaxon:260799	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAT54155.1		"[{""reference_id"": ""NCBIProtein:AAT54155.1"", ""source_assertion"": ""The source feature explicitly records strain Sterne and taxon:260799."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""AAT54155.1\""]/GBSeq_feature-table/GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}]"	"[{""id"": ""NCBIProtein:AAT54155.1"", ""source_sha256"": ""e67b0c1bae9128c5c1688e1d358003f1bac3ff5b2a0e03685d4ebe29ca72bc20"", ""source_version"": ""Original NCBI GenPept six-entry batch retrieved 2026-10-11; digest covers complete unmodified batch"", ""title"": ""AMP-binding protein [Bacillus anthracis str. Sterne]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAT54153.1,AAT54154.1,AAT54155.1,AAT54156.1,AAT54157.1,AAT54158.1&rettype=gb&retmode=xml""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-077_0b7ff4724b9c	NCBIProtein:AAT54156.1	BFO:0000050	NCBITaxon:260799	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAT54156.1		"[{""reference_id"": ""NCBIProtein:AAT54156.1"", ""source_assertion"": ""The source feature explicitly records strain Sterne and taxon:260799."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""AAT54156.1\""]/GBSeq_feature-table/GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}]"	"[{""id"": ""NCBIProtein:AAT54156.1"", ""source_sha256"": ""e67b0c1bae9128c5c1688e1d358003f1bac3ff5b2a0e03685d4ebe29ca72bc20"", ""source_version"": ""Original NCBI GenPept six-entry batch retrieved 2026-10-11; digest covers complete unmodified batch"", ""title"": ""hypothetical protein BAS1841 [Bacillus anthracis str. Sterne]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAT54153.1,AAT54154.1,AAT54155.1,AAT54156.1,AAT54157.1,AAT54158.1&rettype=gb&retmode=xml""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-078_bd32741f1c63	NCBIProtein:AAT54157.1	BFO:0000050	NCBITaxon:260799	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAT54157.1		"[{""reference_id"": ""NCBIProtein:AAT54157.1"", ""source_assertion"": ""The source feature explicitly records strain Sterne and taxon:260799."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""AAT54157.1\""]/GBSeq_feature-table/GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}]"	"[{""id"": ""NCBIProtein:AAT54157.1"", ""source_sha256"": ""e67b0c1bae9128c5c1688e1d358003f1bac3ff5b2a0e03685d4ebe29ca72bc20"", ""source_version"": ""Original NCBI GenPept six-entry batch retrieved 2026-10-11; digest covers complete unmodified batch"", ""title"": ""hypothetical protein BAS1842 [Bacillus anthracis str. Sterne]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAT54153.1,AAT54154.1,AAT54155.1,AAT54156.1,AAT54157.1,AAT54158.1&rettype=gb&retmode=xml""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-079_0d224e554e2a	NCBIProtein:AAT54158.1	BFO:0000050	NCBITaxon:260799	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAT54158.1		"[{""reference_id"": ""NCBIProtein:AAT54158.1"", ""source_assertion"": ""The source feature explicitly records strain Sterne and taxon:260799."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""AAT54158.1\""]/GBSeq_feature-table/GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}]"	"[{""id"": ""NCBIProtein:AAT54158.1"", ""source_sha256"": ""e67b0c1bae9128c5c1688e1d358003f1bac3ff5b2a0e03685d4ebe29ca72bc20"", ""source_version"": ""Original NCBI GenPept six-entry batch retrieved 2026-10-11; digest covers complete unmodified batch"", ""title"": ""conserved hypothetical protein [Bacillus anthracis str. Sterne]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAT54153.1,AAT54154.1,AAT54155.1,AAT54156.1,AAT54157.1,AAT54158.1&rettype=gb&retmode=xml""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-080_1db65716c906	MetaCyc:CPLX-7874	BFO:0000051	NCBIProtein:AAT54158.1	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-7874|MetaCyc:MONOMER-14940|NCBIProtein:AAT54158.1|PMID:18955706|UniProtKB:Q81RQ4	Two AsbF subunits per source-defined dimer. The source Sterne translation and current reviewed Q81RQ4 sequence compare exactly; generic carrier-state counts elsewhere are not subunit counts.	"[{""reference_id"": ""MetaCyc:CPLX-7874"", ""source_assertion"": ""The native complex component is MONOMER-14940 with coefficient 2."", ""source_locator"": ""Protein[@frameid=\""CPLX-7874\""]/component/Protein; component/coefficient""}, {""reference_id"": ""MetaCyc:MONOMER-14940"", ""source_assertion"": ""The native AsbF monomer cross-references UniProt Q81RQ4."", ""source_locator"": ""Protein[@frameid=\""MONOMER-14940\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}, {""reference_id"": ""NCBIProtein:AAT54158.1"", ""source_assertion"": ""The original entry supplies the versioned Sterne AsbF sequence used in the independent comparison; it does not identify every experimental tag."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""AAT54158.1\""]/GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q81RQ4"", ""source_assertion"": ""The reviewed full sequence supplies the independent exact comparison for the native AsbF component."", ""source_locator"": ""/primaryAccession; /sequence/value""}, {""quote"": ""also supports a dimeric state of the enzyme in solution"", ""reference_id"": ""PMID:18955706"", ""source_locator"": ""PMC2579390 Results/sec5/p[2]""}]"	"[{""id"": ""MetaCyc:CPLX-7874"", ""source_sha256"": ""5896a9ab1cae231197f76ba3da527cf34b98958c5e09a53502371842ac4bb3a8"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native CPLX-7874"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-7874""}, {""id"": ""MetaCyc:MONOMER-14940"", ""source_sha256"": ""89aa0d279eb93c52af6b17c405d76a51811e67222c06ce250bb852c9487d522a"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native MONOMER-14940"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-14940""}, {""id"": ""NCBIProtein:AAT54158.1"", ""source_sha256"": ""e67b0c1bae9128c5c1688e1d358003f1bac3ff5b2a0e03685d4ebe29ca72bc20"", ""source_version"": ""Original NCBI GenPept six-entry batch retrieved 2026-10-11; digest covers complete unmodified batch"", ""title"": ""conserved hypothetical protein [Bacillus anthracis str. Sterne]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAT54153.1,AAT54154.1,AAT54155.1,AAT54156.1,AAT54157.1,AAT54158.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:18955706"", ""source_sha256"": ""7c083d2a8097c0be99f1b2a219b02b7171b60defb8e67abd65ffe4c71e6a4b40"", ""source_version"": ""Original full article in PMC HTML retrieved 2026-10-11"", ""title"": ""Structural and functional analysis of AsbF: Origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2579390/""}, {""id"": ""UniProtKB:Q81RQ4"", ""source_sha256"": ""31562441b3dfffd0875991b366b829d3c20dd1b530b74a4a2405e22b2aa99483"", ""source_version"": ""UniProt 2026_03; complete original reviewed entry retrieved 2026-10-11"", ""title"": ""UniProtKB reviewed Q81RQ4"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q81RQ4.json""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-081_06fcac7509f1	MetaCyc:CPLX-7874	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:18955706|UniProtKB:Q81RQ4	Manganese is the experimentally preferred bound metal in the inspected preparation; the edge does not assert exclusive physiological metal use.	"[{""reference_id"": ""UniProtKB:Q81RQ4"", ""source_assertion"": ""The reviewed COFACTOR comment assigns Mn(2+) with ECO:0000269, citing PMID:18955706."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}, {""reference_id"": ""PMID:18955706"", ""source_assertion"": ""Metal rescue and structural analysis support manganese binding; other divalent metals can reactivate the preparation."", ""source_locator"": ""PMC2579390 Results/sec4/p[1]; sec5/p[2]""}]"	"[{""id"": ""PMID:18955706"", ""source_sha256"": ""7c083d2a8097c0be99f1b2a219b02b7171b60defb8e67abd65ffe4c71e6a4b40"", ""source_version"": ""Original full article in PMC HTML retrieved 2026-10-11"", ""title"": ""Structural and functional analysis of AsbF: Origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2579390/""}, {""id"": ""UniProtKB:Q81RQ4"", ""source_sha256"": ""31562441b3dfffd0875991b366b829d3c20dd1b530b74a4a2405e22b2aa99483"", ""source_version"": ""UniProt 2026_03; complete original reviewed entry retrieved 2026-10-11"", ""title"": ""UniProtKB reviewed Q81RQ4"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q81RQ4.json""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-082_f066d6e9e15c	NCBIProtein:AAT54156.1	BFO:0000050	MetaCyc:PWY-6289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:AAT54156.1|PMID:17346033|UniProtKB:Q81RQ6	The selected versioned Sterne AsbD protein participates in petrobactin biosynthesis. This contextual participation does not assert an exact identity between AsbD and every member of the generic carrier classes.	"[{""reference_id"": ""NCBIProtein:AAT54156.1"", ""source_assertion"": ""The versioned Sterne carrier protein supplies the selected AsbD gene-product identity."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""AAT54156.1\""]/GBSeq_feature-table; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q81RQ6"", ""source_assertion"": ""The reviewed carrier entry assigns aryl-carrier function and phosphopantetheinyl activation of Ser-40 with ECO:0000269."", ""source_locator"": ""/comments/0/texts; /comments/2/texts""}, {""reference_id"": ""PMID:17346033"", ""source_assertion"": ""The abstract identifies AsbD as the carrier receiving the AsbC-activated aromatic unit."", ""source_locator"": ""resultList/result[id=\""17346033\""]/abstractText""}]"	"[{""id"": ""NCBIProtein:AAT54156.1"", ""source_sha256"": ""e67b0c1bae9128c5c1688e1d358003f1bac3ff5b2a0e03685d4ebe29ca72bc20"", ""source_version"": ""Original NCBI GenPept six-entry batch retrieved 2026-10-11; digest covers complete unmodified batch"", ""title"": ""hypothetical protein BAS1841 [Bacillus anthracis str. Sterne]"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAT54153.1,AAT54154.1,AAT54155.1,AAT54156.1,AAT54157.1,AAT54158.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:17346033"", ""source_sha256"": ""26b83f8176ad47257f0d82855e9dde65ac3c358b57f754a40358919808a5a245"", ""source_version"": ""Europe PMC original indexed abstract only, retrieved 2026-10-11; original full article unavailable through inspected routes"", ""title"": ""Characterization and analysis of early enzymes for petrobactin biosynthesis in Bacillus anthracis."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17346033&format=json&resultType=core""}, {""id"": ""UniProtKB:Q81RQ6"", ""source_sha256"": ""ea893c52b70f6ec5676acb2fda596b45f69c7aefa64699c6e8994e3b7360d09f"", ""source_version"": ""UniProt 2026_03; complete original reviewed entry retrieved 2026-10-11"", ""title"": ""UniProtKB reviewed Q81RQ6"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q81RQ6.json""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-083_fbc7507bc2df	RHEA:48405	RO:0002413	RHEA:62477	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:48405|RHEA:62477	The independently sourced sides identify the shared intermediate. These convergent branches are supported in vitro; the graph does not choose a unique intracellular flux order. This is a whole generic aryl-carrier state, not free phosphopantetheine or an exact AsbD sequence. Chemical class coefficients do not specify enzyme assembly stoichiometry.	"[{""reference_id"": ""RHEA:48405"", ""source_assertion"": ""RHEA:48405 assigns RHEA-COMP:15903 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/48405 rh:products http://rdf.rhea-db.org/48404_R; http://rdf.rhea-db.org/48404_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_48404_compound_15903; rh:compound http://rdf.rhea-db.org/Compound_15903; rh:name and rh:reactivePart""}, {""reference_id"": ""RHEA:62477"", ""source_assertion"": ""RHEA:62477 assigns RHEA-COMP:15903 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/62477 rh:substrates http://rdf.rhea-db.org/62476_L; http://rdf.rhea-db.org/62476_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_62476_compound_15903; rh:compound http://rdf.rhea-db.org/Compound_15903; rh:name and rh:reactivePart""}]"	"[{""id"": ""RHEA:48405"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 48405"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:62477"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62477"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-084_00b557dc7ba0	RHEA:24849	RO:0002413	RHEA:62469	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24849|RHEA:62469	The independently sourced sides identify the shared intermediate. These convergent branches are supported in vitro; the graph does not choose a unique intracellular flux order.	"[{""reference_id"": ""RHEA:24849"", ""source_assertion"": ""RHEA:24849 assigns CHEBI:36241 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/24849 rh:products http://rdf.rhea-db.org/24848_R; http://rdf.rhea-db.org/24848_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_24848_compound_3099; rh:compound http://rdf.rhea-db.org/Compound_3099; rh:chebi""}, {""reference_id"": ""RHEA:62469"", ""source_assertion"": ""RHEA:62469 assigns CHEBI:36241 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/62469 rh:substrates http://rdf.rhea-db.org/62468_L; http://rdf.rhea-db.org/62468_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_62468_compound_3099; rh:compound http://rdf.rhea-db.org/Compound_3099; rh:chebi""}]"	"[{""id"": ""RHEA:24849"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 24849"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:62469"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62469"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-085_d37ad07893c0	RHEA:62469	RO:0002413	RHEA:62477	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:62469|RHEA:62477	The independently sourced sides identify the shared intermediate. These convergent branches are supported in vitro; the graph does not choose a unique intracellular flux order.	"[{""reference_id"": ""RHEA:62469"", ""source_assertion"": ""RHEA:62469 assigns CHEBI:144942 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/62469 rh:products http://rdf.rhea-db.org/62468_R; http://rdf.rhea-db.org/62468_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_62468_compound_16102; rh:compound http://rdf.rhea-db.org/Compound_16102; rh:chebi""}, {""reference_id"": ""RHEA:62477"", ""source_assertion"": ""RHEA:62477 assigns CHEBI:144942 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/62477 rh:substrates http://rdf.rhea-db.org/62476_L; http://rdf.rhea-db.org/62476_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_62476_compound_16102; rh:compound http://rdf.rhea-db.org/Compound_16102; rh:chebi""}]"	"[{""id"": ""RHEA:62469"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62469"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:62477"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62477"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-086_0288e20686cb	RHEA:63809	RO:0002413	RHEA:63813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63809|RHEA:63813	The independently sourced sides identify the shared intermediate. These convergent branches are supported in vitro; the graph does not choose a unique intracellular flux order.	"[{""reference_id"": ""RHEA:63809"", ""source_assertion"": ""RHEA:63809 assigns CHEBI:149586 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63809 rh:products http://rdf.rhea-db.org/63808_R; http://rdf.rhea-db.org/63808_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63808_compound_16439; rh:compound http://rdf.rhea-db.org/Compound_16439; rh:chebi""}, {""reference_id"": ""RHEA:63813"", ""source_assertion"": ""RHEA:63813 assigns CHEBI:149586 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63813 rh:substrates http://rdf.rhea-db.org/63812_L; http://rdf.rhea-db.org/63812_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63812_compound_16439; rh:compound http://rdf.rhea-db.org/Compound_16439; rh:chebi""}]"	"[{""id"": ""RHEA:63809"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63809"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:63813"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63813"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-087_439586e83870	RHEA:63809	RO:0002413	RHEA:64029	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63809|RHEA:64029	The independently sourced sides identify the shared intermediate. These convergent branches are supported in vitro; the graph does not choose a unique intracellular flux order.	"[{""reference_id"": ""RHEA:63809"", ""source_assertion"": ""RHEA:63809 assigns CHEBI:149586 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63809 rh:products http://rdf.rhea-db.org/63808_R; http://rdf.rhea-db.org/63808_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63808_compound_16439; rh:compound http://rdf.rhea-db.org/Compound_16439; rh:chebi""}, {""reference_id"": ""RHEA:64029"", ""source_assertion"": ""RHEA:64029 assigns CHEBI:149586 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/64029 rh:substrates http://rdf.rhea-db.org/64028_L; http://rdf.rhea-db.org/64028_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_64028_compound_16439; rh:compound http://rdf.rhea-db.org/Compound_16439; rh:chebi""}]"	"[{""id"": ""RHEA:63809"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63809"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:64029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 64029"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-088_309e78697d12	RHEA:64029	RO:0002413	RHEA:63817	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63817|RHEA:64029	The independently sourced sides identify the shared intermediate. These convergent branches are supported in vitro; the graph does not choose a unique intracellular flux order.	"[{""reference_id"": ""RHEA:64029"", ""source_assertion"": ""RHEA:64029 assigns CHEBI:149593 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/64029 rh:products http://rdf.rhea-db.org/64028_R; http://rdf.rhea-db.org/64028_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_64028_compound_16442; rh:compound http://rdf.rhea-db.org/Compound_16442; rh:chebi""}, {""reference_id"": ""RHEA:63817"", ""source_assertion"": ""RHEA:63817 assigns CHEBI:149593 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63817 rh:substrates http://rdf.rhea-db.org/63816_L; http://rdf.rhea-db.org/63816_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63816_compound_16442; rh:compound http://rdf.rhea-db.org/Compound_16442; rh:chebi""}]"	"[{""id"": ""RHEA:63817"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63817"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:64029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 64029"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-089_60f21c460e22	RHEA:63813	RO:0002413	RHEA:64025	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:63813|RHEA:64025	The independently sourced sides identify the shared intermediate. These convergent branches are supported in vitro; the graph does not choose a unique intracellular flux order.	"[{""reference_id"": ""RHEA:63813"", ""source_assertion"": ""RHEA:63813 assigns CHEBI:149592 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63813 rh:products http://rdf.rhea-db.org/63812_R; http://rdf.rhea-db.org/63812_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63812_compound_16440; rh:compound http://rdf.rhea-db.org/Compound_16440; rh:chebi""}, {""reference_id"": ""RHEA:64025"", ""source_assertion"": ""RHEA:64025 assigns CHEBI:149592 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/64025 rh:substrates http://rdf.rhea-db.org/64024_L; http://rdf.rhea-db.org/64024_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_64024_compound_16440; rh:compound http://rdf.rhea-db.org/Compound_16440; rh:chebi""}]"	"[{""id"": ""RHEA:63813"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63813"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:64025"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 64025"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-090_84e3bb72483e	RHEA:63817	RO:0002413	MetaCyc:RXN-10679	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-10679|RHEA:63817	The independently sourced sides identify the shared intermediate. These convergent branches are supported in vitro; the graph does not choose a unique intracellular flux order.	"[{""reference_id"": ""RHEA:63817"", ""source_assertion"": ""RHEA:63817 assigns CHEBI:149594 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/63817 rh:products http://rdf.rhea-db.org/63816_R; http://rdf.rhea-db.org/63816_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_63816_compound_16441; rh:compound http://rdf.rhea-db.org/Compound_16441; rh:chebi""}, {""reference_id"": ""MetaCyc:RXN-10679"", ""source_assertion"": ""The native terminal equation places CPD-11481 on its left side with unit coefficient and physiological left-to-right direction."", ""source_locator"": ""Reaction[@frameid=\""RXN-10679\""]/left/*[@frameid=\""CPD-11481\""]; reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-10679"", ""source_sha256"": ""8be52d7f87ddb9b1371436d745bb5266519b7e9d1c8ec0f160477465f0832ba5"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-10679"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10679""}, {""id"": ""RHEA:63817"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 63817"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-091_2932551a9a95	RHEA:64025	RO:0002413	MetaCyc:RXN-10679	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-10679|RHEA:64025	The independently sourced sides identify the shared intermediate. These convergent branches are supported in vitro; the graph does not choose a unique intracellular flux order.	"[{""reference_id"": ""RHEA:64025"", ""source_assertion"": ""RHEA:64025 assigns CHEBI:149594 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/64025 rh:products http://rdf.rhea-db.org/64024_R; http://rdf.rhea-db.org/64024_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_64024_compound_16441; rh:compound http://rdf.rhea-db.org/Compound_16441; rh:chebi""}, {""reference_id"": ""MetaCyc:RXN-10679"", ""source_assertion"": ""The native terminal equation places CPD-11481 on its left side with unit coefficient and physiological left-to-right direction."", ""source_locator"": ""Reaction[@frameid=\""RXN-10679\""]/left/*[@frameid=\""CPD-11481\""]; reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-10679"", ""source_sha256"": ""8be52d7f87ddb9b1371436d745bb5266519b7e9d1c8ec0f160477465f0832ba5"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-10679"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10679""}, {""id"": ""RHEA:64025"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 64025"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-092_6553698c8a30	RHEA:62477	RO:0002413	RHEA:64029	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:62477|RHEA:64029	The independently sourced sides identify the shared intermediate. These convergent branches are supported in vitro; the graph does not choose a unique intracellular flux order. This is a whole generic aryl-carrier state, not free phosphopantetheine or an exact AsbD sequence. Chemical class coefficients do not specify enzyme assembly stoichiometry.	"[{""reference_id"": ""RHEA:62477"", ""source_assertion"": ""RHEA:62477 assigns RHEA-COMP:15941 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/62477 rh:products http://rdf.rhea-db.org/62476_R; http://rdf.rhea-db.org/62476_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_62476_compound_15941; rh:compound http://rdf.rhea-db.org/Compound_15941; rh:name and rh:reactivePart""}, {""reference_id"": ""RHEA:64029"", ""source_assertion"": ""RHEA:64029 assigns RHEA-COMP:15941 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/64029 rh:substrates http://rdf.rhea-db.org/64028_L; http://rdf.rhea-db.org/64028_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_64028_compound_15941; rh:compound http://rdf.rhea-db.org/Compound_15941; rh:name and rh:reactivePart""}]"	"[{""id"": ""RHEA:62477"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62477"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:64029"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 64029"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-093_a47c5dd3a633	RHEA:62477	RO:0002413	RHEA:64025	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:62477|RHEA:64025	The independently sourced sides identify the shared intermediate. These convergent branches are supported in vitro; the graph does not choose a unique intracellular flux order. This is a whole generic aryl-carrier state, not free phosphopantetheine or an exact AsbD sequence. Chemical class coefficients do not specify enzyme assembly stoichiometry.	"[{""reference_id"": ""RHEA:62477"", ""source_assertion"": ""RHEA:62477 assigns RHEA-COMP:15941 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/62477 rh:products http://rdf.rhea-db.org/62476_R; http://rdf.rhea-db.org/62476_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_62476_compound_15941; rh:compound http://rdf.rhea-db.org/Compound_15941; rh:name and rh:reactivePart""}, {""reference_id"": ""RHEA:64025"", ""source_assertion"": ""RHEA:64025 assigns RHEA-COMP:15941 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/64025 rh:substrates http://rdf.rhea-db.org/64024_L; http://rdf.rhea-db.org/64024_L http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_64024_compound_15941; rh:compound http://rdf.rhea-db.org/Compound_15941; rh:name and rh:reactivePart""}]"	"[{""id"": ""RHEA:62477"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62477"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:64025"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 64025"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6289_petrobactin-edge-094_4c23992a43d1	RHEA:62477	RO:0002413	MetaCyc:RXN-10679	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-10679|RHEA:62477	The independently sourced sides identify the shared intermediate. These convergent branches are supported in vitro; the graph does not choose a unique intracellular flux order. This is a whole generic aryl-carrier state, not free phosphopantetheine or an exact AsbD sequence. Chemical class coefficients do not specify enzyme assembly stoichiometry.	"[{""reference_id"": ""RHEA:62477"", ""source_assertion"": ""RHEA:62477 assigns RHEA-COMP:15941 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/62477 rh:products http://rdf.rhea-db.org/62476_R; http://rdf.rhea-db.org/62476_R http://rdf.rhea-db.org/contains1 http://rdf.rhea-db.org/Participant_62476_compound_15941; rh:compound http://rdf.rhea-db.org/Compound_15941; rh:name and rh:reactivePart""}, {""reference_id"": ""MetaCyc:RXN-10679"", ""source_assertion"": ""The native terminal equation places 34-DHB-AsbD-Proteins on its left side with unit coefficient and physiological left-to-right direction."", ""source_locator"": ""Reaction[@frameid=\""RXN-10679\""]/left/*[@frameid=\""34-DHB-AsbD-Proteins\""]; reaction-direction""}]"	"[{""id"": ""MetaCyc:RXN-10679"", ""source_sha256"": ""8be52d7f87ddb9b1371436d745bb5266519b7e9d1c8ec0f160477465f0832ba5"", ""source_version"": ""MetaCyc 22.5; original XML retrieved 2026-10-11"", ""title"": ""MetaCyc native RXN-10679"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-10679""}, {""id"": ""RHEA:62477"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA-256 covers complete original gzip RDF"", ""title"": ""Rhea directed reaction 62477"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-001_0ee7168563e8	gomodel:RXN-10814	BFO:0000050	GO:0009094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:RXN-10814 BFO:0000050 gomodel:YeastPathways_PWY3O-4153/YeastPathways_PWY3O-4153."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/0; endpoint types: /individuals/15/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-002_f7a23e6a2cb7	gomodel:2.6.1.58-RXN	RO:0002234	CHEBI:58095	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:2.6.1.58-RXN RO:0002234 gomodel:CHEBI_58095_2.6.1.58-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/1; endpoint types: /individuals/44/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-003_c99ea6e1f324	gomodel:2.6.1.58-RXN	RO:0002233	CHEBI:57972	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:2.6.1.58-RXN RO:0002233 gomodel:CHEBI_57972_2.6.1.58-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/2; endpoint types: /individuals/44/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-004_29f5e041c39b	gomodel:PREPHENATEDEHYDRAT-RXN	BFO:0000050	GO:0009094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:PREPHENATEDEHYDRAT-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4153/YeastPathways_PWY3O-4153."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/3; endpoint types: /individuals/14/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-005_65797677dab5	gomodel:CHORISMATEMUT-RXN	RO:0002234	CHEBI:29934	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:CHORISMATEMUT-RXN RO:0002234 gomodel:CHEBI_29934_CHORISMATEMUT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/4; endpoint types: /individuals/12/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-006_5f4e3e23bcb6	gomodel:RXN-10814	RO:0002233	CHEBI:18005	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:RXN-10814 RO:0002233 gomodel:CHEBI_18005_PREPHENATEDEHYDRAT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/5; endpoint types: /individuals/15/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-007_413299e0883f	gomodel:RXN-10814	RO:0002234	CHEBI:58095	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:RXN-10814 RO:0002234 gomodel:CHEBI_58095_RXN-10814."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/6; endpoint types: /individuals/15/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-008_6ea310e6a6a2	SGD:S000003170	pathwaymech:enables	gomodel:RXN-10814	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:RXN-10814 RO:0002333 gomodel:YeastPathways_PWY3O-4153/6690711d00000281."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/7; endpoint types: /individuals/15/type; /individuals/46/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-009_dd55de4ad2c5	gomodel:RXN-10814	RO:0002234	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:RXN-10814 RO:0002234 gomodel:CHEBI_16810_RXN-10814."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/8; endpoint types: /individuals/15/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-010_b5c8e0c1f9a7	SGD:S000005260	pathwaymech:enables	gomodel:PREPHENATEDEHYDRAT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:PREPHENATEDEHYDRAT-RXN RO:0002333 gomodel:MONOMER3O-279_PREPHENATEDEHYDRAT-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/9; endpoint types: /individuals/14/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-011_b57011eb59de	gomodel:CHORISMATEMUT-RXN	BFO:0000050	GO:0009094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:CHORISMATEMUT-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4153/YeastPathways_PWY3O-4153."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/10; endpoint types: /individuals/12/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-012_f7ab385e12fe	gomodel:CHORISMATEMUT-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:CHORISMATEMUT-RXN BFO:0000066 gomodel:reaction_CHORISMATEMUT-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/11; endpoint types: /individuals/12/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-013_938a151625f2	gomodel:PREPHENATEDEHYDRAT-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:PREPHENATEDEHYDRAT-RXN RO:0002234 gomodel:CHEBI_16526_PREPHENATEDEHYDRAT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/12; endpoint types: /individuals/14/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-014_ec5a1e0ee9e6	gomodel:2.6.1.58-RXN	RO:0002233	CHEBI:18005	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:2.6.1.58-RXN RO:0002233 gomodel:CHEBI_18005_PREPHENATEDEHYDRAT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/13; endpoint types: /individuals/44/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-015_ae3139dfe41a	SGD:S000006264	pathwaymech:enables	gomodel:CHORISMATEMUT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:CHORISMATEMUT-RXN RO:0002333 gomodel:YPR060C-MONOMER_CHORISMATEMUT-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/14; endpoint types: /individuals/12/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-016_6bbbbbdebf3b	gomodel:2.6.1.58-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:2.6.1.58-RXN BFO:0000066 gomodel:reaction_2.6.1.58-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/15; endpoint types: /individuals/44/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-017_ac0d9bdb4147	gomodel:PREPHENATEDEHYDRAT-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:PREPHENATEDEHYDRAT-RXN RO:0002233 gomodel:CHEBI_15378_PREPHENATEDEHYDRAT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/16; endpoint types: /individuals/14/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-018_2f0bc775df6c	gomodel:CHORISMATEMUT-RXN	RO:0002233	CHEBI:29748	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:CHORISMATEMUT-RXN RO:0002233 gomodel:CHEBI_29748_CHORISMATEMUT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/17; endpoint types: /individuals/12/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-019_afa76c647b50	gomodel:2.6.1.58-RXN	BFO:0000050	GO:0009094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:2.6.1.58-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4153/YeastPathways_PWY3O-4153."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/18; endpoint types: /individuals/44/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-020_8aa5c5a6a060	gomodel:PREPHENATEDEHYDRAT-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:PREPHENATEDEHYDRAT-RXN BFO:0000066 gomodel:reaction_PREPHENATEDEHYDRAT-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/19; endpoint types: /individuals/14/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-021_a1a7818b1a2e	gomodel:2.6.1.58-RXN	RO:0002234	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:2.6.1.58-RXN RO:0002234 gomodel:CHEBI_15361_2.6.1.58-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/20; endpoint types: /individuals/44/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-022_5014a0d894fa	gomodel:RXN-10814	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:RXN-10814 BFO:0000066 gomodel:reaction_RXN-10814_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/21; endpoint types: /individuals/15/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-023_bc0bbf44e726	gomodel:PREPHENATEDEHYDRAT-RXN	RO:0002233	CHEBI:29934	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:PREPHENATEDEHYDRAT-RXN RO:0002233 gomodel:CHEBI_29934_CHORISMATEMUT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/22; endpoint types: /individuals/14/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-024_43093ac6a45f	gomodel:PREPHENATEDEHYDRAT-RXN	RO:0002234	CHEBI:18005	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:PREPHENATEDEHYDRAT-RXN RO:0002234 gomodel:CHEBI_18005_PREPHENATEDEHYDRAT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/23; endpoint types: /individuals/14/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-025_0b2a7ee60514	gomodel:PREPHENATEDEHYDRAT-RXN	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:PREPHENATEDEHYDRAT-RXN RO:0002234 gomodel:CHEBI_15377_PREPHENATEDEHYDRAT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/24; endpoint types: /individuals/14/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-026_8b7410441d7c	gomodel:RXN-10814	RO:0002233	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:RXN-10814 RO:0002233 gomodel:CHEBI_29985_RXN-10814."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/25; endpoint types: /individuals/15/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_edge-027_16fc6033fa6f	SGD:S000001179	pathwaymech:enables	gomodel:2.6.1.58-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4153		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_assertion"": ""The model asserts gomodel:2.6.1.58-RXN RO:0002333 gomodel:YHR137W-MONOMER_2.6.1.58-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-4153.json#/facts/26; endpoint types: /individuals/44/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4153"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-08; member ./YeastPathways_PWY3O-4153.json"", ""title"": ""SGD GO-CAM phenylalanine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_location-ad4354e8d3df_fd0f418253ec	SGD:S000003170	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53090	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2112/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 has the exact SGD cross-reference SGD:S000003170."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2112/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53090"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53090 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_location-0fb6a3725c0e_8b358cd9e776	SGD:S000005260	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32452	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P32452"", ""source_assertion"": ""UniProtKB:P32452 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4536/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32452"", ""source_assertion"": ""UniProtKB:P32452 has the exact SGD cross-reference SGD:S000005260."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4536/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32452"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32452 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_location-b3fbf570a53d_da155009e26a	SGD:S000006264	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32178	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12455686)	"[{""reference_id"": ""UniProtKB:P32178"", ""source_assertion"": ""UniProtKB:P32178 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/855/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32178"", ""source_assertion"": ""UniProtKB:P32178 has the exact SGD cross-reference SGD:S000006264."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/855/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32178"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32178 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_location-21257d2833bc_b8b5dc4c83f2	SGD:S000001179	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38840	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1469/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 has the exact SGD cross-reference SGD:S000001179."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1469/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38840"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38840 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_cofactor-46a0dec0bfb8_c641dba5a84f	SGD:S000003170	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53090	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:23893908)	"[{""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 has the exact SGD cross-reference SGD:S000003170."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53090"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53090 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4153_cofactor-eb2a9050a8eb_57bf11b5409f	SGD:S000001179	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38840	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:O84395)	"[{""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1469/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 has the exact SGD cross-reference SGD:S000001179."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1469/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38840"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38840 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-001_4f720f0d43e3	CHEBI:225237	pathwaymech:consumes	RHEA:25266	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25266		"[{""reference_id"": ""RHEA:25266"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:225237 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25266/rh:substrates -> http://rdf.rhea-db.org/25265_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_25265_compound_4466/rh:compound -> http://rdf.rhea-db.org/Compound_4466/rh:chebi""}]"	"[{""id"": ""RHEA:25266"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release2026-09-02; digest covers complete native RDF gzip, selected objects identified in source locators"", ""title"": ""Rhea directed reaction 25266"", ""url"": ""https://www.rhea-db.org/rhea/25266""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-002_4ba020b4445f	CHEBI:15379	pathwaymech:consumes	RHEA:25266	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25266		"[{""reference_id"": ""RHEA:25266"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:15379 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25266/rh:substrates -> http://rdf.rhea-db.org/25265_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_25265_compound_1198/rh:compound -> http://rdf.rhea-db.org/Compound_1198/rh:chebi""}]"	"[{""id"": ""RHEA:25266"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release2026-09-02; digest covers complete native RDF gzip, selected objects identified in source locators"", ""title"": ""Rhea directed reaction 25266"", ""url"": ""https://www.rhea-db.org/rhea/25266""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-003_46d0cbca89ff	CHEBI:15377	pathwaymech:consumes	RHEA:25266	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25266		"[{""reference_id"": ""RHEA:25266"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:15377 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25266/rh:substrates -> http://rdf.rhea-db.org/25265_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_25265_compound_1283/rh:compound -> http://rdf.rhea-db.org/Compound_1283/rh:chebi""}]"	"[{""id"": ""RHEA:25266"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release2026-09-02; digest covers complete native RDF gzip, selected objects identified in source locators"", ""title"": ""Rhea directed reaction 25266"", ""url"": ""https://www.rhea-db.org/rhea/25266""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-004_380c3266dc80	RHEA:25266	pathwaymech:produces	CHEBI:16424	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25266		"[{""reference_id"": ""RHEA:25266"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:16424 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25266/rh:products -> http://rdf.rhea-db.org/25265_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_25265_compound_2222/rh:compound -> http://rdf.rhea-db.org/Compound_2222/rh:chebi""}]"	"[{""id"": ""RHEA:25266"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release2026-09-02; digest covers complete native RDF gzip, selected objects identified in source locators"", ""title"": ""Rhea directed reaction 25266"", ""url"": ""https://www.rhea-db.org/rhea/25266""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-005_d004a80dd079	RHEA:25266	pathwaymech:produces	CHEBI:16240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25266		"[{""reference_id"": ""RHEA:25266"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:16240 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25266/rh:products -> http://rdf.rhea-db.org/25265_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_25265_compound_3075/rh:compound -> http://rdf.rhea-db.org/Compound_3075/rh:chebi""}]"	"[{""id"": ""RHEA:25266"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release2026-09-02; digest covers complete native RDF gzip, selected objects identified in source locators"", ""title"": ""Rhea directed reaction 25266"", ""url"": ""https://www.rhea-db.org/rhea/25266""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-006_eca3e5836b61	RHEA:25266	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25266		"[{""reference_id"": ""RHEA:25266"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:28938 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25266/rh:products -> http://rdf.rhea-db.org/25265_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_25265_compound_1012/rh:compound -> http://rdf.rhea-db.org/Compound_1012/rh:chebi""}]"	"[{""id"": ""RHEA:25266"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release2026-09-02; digest covers complete native RDF gzip, selected objects identified in source locators"", ""title"": ""Rhea directed reaction 25266"", ""url"": ""https://www.rhea-db.org/rhea/25266""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-007_667db3e45266	CHEBI:16424	pathwaymech:consumes	RHEA:21393	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21393		"[{""reference_id"": ""RHEA:21393"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:16424 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/21393/rh:substrates -> http://rdf.rhea-db.org/21392_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_21392_compound_2222/rh:compound -> http://rdf.rhea-db.org/Compound_2222/rh:chebi""}]"	"[{""id"": ""RHEA:21393"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release2026-09-02; digest covers complete native RDF gzip, selected objects identified in source locators"", ""title"": ""Rhea directed reaction 21393"", ""url"": ""https://www.rhea-db.org/rhea/21393""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-008_c4ae6756da3d	CHEBI:57540	pathwaymech:consumes	RHEA:21393	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21393		"[{""reference_id"": ""RHEA:21393"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:57540 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/21393/rh:substrates -> http://rdf.rhea-db.org/21392_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_21392_compound_3484/rh:compound -> http://rdf.rhea-db.org/Compound_3484/rh:chebi""}]"	"[{""id"": ""RHEA:21393"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release2026-09-02; digest covers complete native RDF gzip, selected objects identified in source locators"", ""title"": ""Rhea directed reaction 21393"", ""url"": ""https://www.rhea-db.org/rhea/21393""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-009_5fd845c241a2	CHEBI:15377	pathwaymech:consumes	RHEA:21393	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21393		"[{""reference_id"": ""RHEA:21393"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:15377 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/21393/rh:substrates -> http://rdf.rhea-db.org/21392_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_21392_compound_1283/rh:compound -> http://rdf.rhea-db.org/Compound_1283/rh:chebi""}]"	"[{""id"": ""RHEA:21393"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release2026-09-02; digest covers complete native RDF gzip, selected objects identified in source locators"", ""title"": ""Rhea directed reaction 21393"", ""url"": ""https://www.rhea-db.org/rhea/21393""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-010_3f58099244b8	RHEA:21393	pathwaymech:produces	CHEBI:18401	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21393		"[{""reference_id"": ""RHEA:21393"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:18401 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/21393/rh:products -> http://rdf.rhea-db.org/21392_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_21392_compound_5243/rh:compound -> http://rdf.rhea-db.org/Compound_5243/rh:chebi""}]"	"[{""id"": ""RHEA:21393"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release2026-09-02; digest covers complete native RDF gzip, selected objects identified in source locators"", ""title"": ""Rhea directed reaction 21393"", ""url"": ""https://www.rhea-db.org/rhea/21393""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-011_a80b846b83cf	RHEA:21393	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21393		"[{""reference_id"": ""RHEA:21393"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:57945 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/21393/rh:products -> http://rdf.rhea-db.org/21392_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_21392_compound_1650/rh:compound -> http://rdf.rhea-db.org/Compound_1650/rh:chebi""}]"	"[{""id"": ""RHEA:21393"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release2026-09-02; digest covers complete native RDF gzip, selected objects identified in source locators"", ""title"": ""Rhea directed reaction 21393"", ""url"": ""https://www.rhea-db.org/rhea/21393""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-012_48d68680bbd4	RHEA:21393	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21393		"[{""reference_id"": ""RHEA:21393"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:15378 on its products side with coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/21393/rh:products -> http://rdf.rhea-db.org/21392_R/rh:contains2 -> http://rdf.rhea-db.org/Participant_21392_compound_3249/rh:compound -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:21393"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release2026-09-02; digest covers complete native RDF gzip, selected objects identified in source locators"", ""title"": ""Rhea directed reaction 21393"", ""url"": ""https://www.rhea-db.org/rhea/21393""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-013_79664c149328	MetaCyc:AMINEOXID-CPLX	BFO:0000051	UniProtKB:P46883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:AMINEOXID-CPLX|MetaCyc:AMINEOXID-MONOMER|UniProtKB:P46883		"[{""reference_id"": ""MetaCyc:AMINEOXID-CPLX"", ""source_assertion"": ""The native TynA assembly contains two AMINEOXID-MONOMER subunits."", ""source_locator"": ""Protein[@frameid=\""AMINEOXID-CPLX\""]/component[Protein/@frameid=\""AMINEOXID-MONOMER\""]/coefficient=2""}, {""reference_id"": ""MetaCyc:AMINEOXID-MONOMER"", ""source_assertion"": ""The native subunit has an explicit UniProt unification cross-reference to P46883."", ""source_locator"": ""Protein[@frameid=\""AMINEOXID-MONOMER\""]/dblink[dblink-db=\""UNIPROT\"" and dblink-oid=\""P46883\""]""}, {""reference_id"": ""UniProtKB:P46883"", ""source_assertion"": ""UniProt records a homodimer, with experimental evidence codes tied to PMID10387067,10576737 and9048544."", ""source_locator"": ""comments[commentType=\""SUBUNIT\""]/texts""}]"	"[{""id"": ""MetaCyc:AMINEOXID-CPLX"", ""source_sha256"": ""73c6c78f0646cbbf311175bf806872b91c81a661bcd3edf994642b311125e2f6"", ""source_version"": ""MetaCyc22.5 native META frame; retrieved2026-10-11"", ""title"": ""MetaCyc AMINEOXID-CPLX: copper-containing amine oxidase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:AMINEOXID-CPLX""}, {""id"": ""MetaCyc:AMINEOXID-MONOMER"", ""source_sha256"": ""95d8dc9e2e10bf78d20895004059445407059a59144c74c0b76243fec85e99ea"", ""source_version"": ""MetaCyc22.5 native META frame; retrieved2026-10-11"", ""title"": ""MetaCyc AMINEOXID-MONOMER: copper-containing amine oxidase subunit"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:AMINEOXID-MONOMER""}, {""id"": ""UniProtKB:P46883"", ""source_sha256"": ""79e7e4a8836d1f449023ae51cd33dd76ef74fbf710af4b3572b4f6bbbee524f9"", ""source_version"": ""Retrieved2026-10-11; entryVersion 206; sequenceVersion 1; annotation date 2026-06-10"", ""title"": ""UniProtKB P46883: Primary amine oxidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46883.json""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-014_be1b5096c3ce	MetaCyc:AMINEOXID-CPLX	pathwaymech:catalyzes	RHEA:25266	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:AMINEOXID-CPLX|RHEA:25266|UniProtKB:P46883		"[{""reference_id"": ""MetaCyc:AMINEOXID-CPLX"", ""source_assertion"": ""Native AMINEPHEN-ENZRXN links this assembly to the phenylethylamine oxidation step."", ""source_locator"": ""Protein[@frameid=\""AMINEOXID-CPLX\""]/catalyzes/Enzymatic-Reaction[@frameid=\""AMINEPHEN-ENZRXN\""]/reaction""}, {""reference_id"": ""UniProtKB:P46883"", ""source_assertion"": ""UniProt experimentally annotates TynA phenylethylamine oxidation and maps it to RHEA:25265."", ""source_locator"": ""comments[commentType=\""CATALYTIC ACTIVITY\""]/reaction[reactionCrossReferences/id=\""RHEA:25265\""]""}, {""reference_id"": ""RHEA:25266"", ""source_assertion"": ""Rhea142 explicitly links master RHEA:25265 to directional reaction RHEA:25266."", ""source_locator"": ""http://rdf.rhea-db.org/25265/rh:directionalReaction -> http://rdf.rhea-db.org/25266""}]"	"[{""id"": ""MetaCyc:AMINEOXID-CPLX"", ""source_sha256"": ""73c6c78f0646cbbf311175bf806872b91c81a661bcd3edf994642b311125e2f6"", ""source_version"": ""MetaCyc22.5 native META frame; retrieved2026-10-11"", ""title"": ""MetaCyc AMINEOXID-CPLX: copper-containing amine oxidase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:AMINEOXID-CPLX""}, {""id"": ""RHEA:25266"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release2026-09-02; digest covers complete native RDF gzip, selected objects identified in source locators"", ""title"": ""Rhea directed reaction 25266"", ""url"": ""https://www.rhea-db.org/rhea/25266""}, {""id"": ""UniProtKB:P46883"", ""source_sha256"": ""79e7e4a8836d1f449023ae51cd33dd76ef74fbf710af4b3572b4f6bbbee524f9"", ""source_version"": ""Retrieved2026-10-11; entryVersion 206; sequenceVersion 1; annotation date 2026-06-10"", ""title"": ""UniProtKB P46883: Primary amine oxidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46883.json""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-015_fcd06c28c988	UniProtKB:P80668	pathwaymech:enables	RHEA:21393	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9043126|RHEA:21393|UniProtKB:P80668	Gene-product/activity association; no isolated-monomer catalysis or fixed oligomer stoichiometry is asserted. The native tetramer and UniProt dimer assignments remain explicitly discordant.	"[{""reference_id"": ""UniProtKB:P80668"", ""source_assertion"": ""UniProt associates K-12 FeaB with phenylacetaldehyde oxidation by NAD+ in RHEA:21392."", ""source_locator"": ""comments[commentType=\""CATALYTIC ACTIVITY\""]/reaction[reactionCrossReferences/id=\""RHEA:21392\""]""}, {""reference_id"": ""PMID:9043126"", ""source_assertion"": ""The K-12 study located the PAD gene and assayed purified PAD against phenylacetaldehyde."", ""source_locator"": ""resultList/result[id=\""9043126\""]/abstractText""}, {""reference_id"": ""RHEA:21393"", ""source_assertion"": ""Rhea142 explicitly links master RHEA:21392 to directional reaction RHEA:21393."", ""source_locator"": ""http://rdf.rhea-db.org/21392/rh:directionalReaction -> http://rdf.rhea-db.org/21393""}]"	"[{""id"": ""PMID:9043126"", ""source_sha256"": ""027066086a6672cd06876bd13421104cb6b860872ba312d8587a26916fa55a45"", ""source_version"": ""Europe PMC core primary-article abstract record; retrieved2026-10-11; digest covers complete six-result JSON response"", ""title"": ""2-phenylethylamine catabolism by Escherichia coli K-12: gene organization and expression."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9043126/""}, {""id"": ""RHEA:21393"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release2026-09-02; digest covers complete native RDF gzip, selected objects identified in source locators"", ""title"": ""Rhea directed reaction 21393"", ""url"": ""https://www.rhea-db.org/rhea/21393""}, {""id"": ""UniProtKB:P80668"", ""source_sha256"": ""19d360d722d1c91156ea361975ea9ace1f151edfb109fe06200c4b97242cf307"", ""source_version"": ""Retrieved2026-10-11; entryVersion 175; sequenceVersion 2; annotation date 2026-09-02"", ""title"": ""UniProtKB P80668: Phenylacetaldehyde dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P80668.json""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-016_d15909deae8e	UniProtKB:P46883	pathwaymech:has_cofactor	CHEBI:23378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P46883		"[{""reference_id"": ""UniProtKB:P46883"", ""source_assertion"": ""Copper binding is experimentally annotated; the entry reports one copper ion per subunit."", ""source_locator"": ""comments[commentType=\""COFACTOR\""]/cofactors[cofactorCrossReference/id=\""CHEBI:23378\""]; associated note/texts and ECO:0000269 evidence""}]"	"[{""id"": ""UniProtKB:P46883"", ""source_sha256"": ""79e7e4a8836d1f449023ae51cd33dd76ef74fbf710af4b3572b4f6bbbee524f9"", ""source_version"": ""Retrieved2026-10-11; entryVersion 206; sequenceVersion 1; annotation date 2026-06-10"", ""title"": ""UniProtKB P46883: Primary amine oxidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46883.json""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-017_296a57276c0f	UniProtKB:P46883	pathwaymech:has_cofactor	CHEBI:29108	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P46883		"[{""reference_id"": ""UniProtKB:P46883"", ""source_assertion"": ""Calcium binding is experimentally annotated; the entry reports two calcium ions per subunit."", ""source_locator"": ""comments[commentType=\""COFACTOR\""]/cofactors[cofactorCrossReference/id=\""CHEBI:29108\""]; associated note/texts and ECO:0000269 evidence""}]"	"[{""id"": ""UniProtKB:P46883"", ""source_sha256"": ""79e7e4a8836d1f449023ae51cd33dd76ef74fbf710af4b3572b4f6bbbee524f9"", ""source_version"": ""Retrieved2026-10-11; entryVersion 206; sequenceVersion 1; annotation date 2026-06-10"", ""title"": ""UniProtKB P46883: Primary amine oxidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46883.json""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-018_b8b5ce7f2563	UniProtKB:P46883	pathwaymech:has_cofactor	CHEBI:79027	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P46883		"[{""reference_id"": ""UniProtKB:P46883"", ""source_assertion"": ""One covalently integrated topaquinone residue per subunit is experimentally annotated; this is not a freely consumed small molecule."", ""source_locator"": ""comments[commentType=\""COFACTOR\""]/cofactors[cofactorCrossReference/id=\""CHEBI:79027\""]; associated note/texts and ECO:0000269 evidence""}]"	"[{""id"": ""UniProtKB:P46883"", ""source_sha256"": ""79e7e4a8836d1f449023ae51cd33dd76ef74fbf710af4b3572b4f6bbbee524f9"", ""source_version"": ""Retrieved2026-10-11; entryVersion 206; sequenceVersion 1; annotation date 2026-06-10"", ""title"": ""UniProtKB P46883: Primary amine oxidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46883.json""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-019_21b559a05b81	UniProtKB:P46883	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P46883		"[{""reference_id"": ""UniProtKB:P46883"", ""source_assertion"": ""UniProt locates TynA in the periplasm."", ""source_locator"": ""comments[commentType=\""SUBCELLULAR LOCATION\""]/subcellularLocations/location[value=\""Periplasm\""]""}]"	"[{""id"": ""UniProtKB:P46883"", ""source_sha256"": ""79e7e4a8836d1f449023ae51cd33dd76ef74fbf710af4b3572b4f6bbbee524f9"", ""source_version"": ""Retrieved2026-10-11; entryVersion 206; sequenceVersion 1; annotation date 2026-06-10"", ""title"": ""UniProtKB P46883: Primary amine oxidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46883.json""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-020_c011b533a9fe	RHEA:25266	BFO:0000066	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:23913322		"[{""reference_id"": ""PMID:23913322"", ""source_assertion"": ""The W3110 study identifies the amine oxidase reaction as periplasmic and measures peroxide formation during aerobic PEA use."", ""source_locator"": ""Introduction; Results, E.coli can utilize phenylethylamine as sole carbon or nitrogen source; Fig.1""}]"	"[{""id"": ""PMID:23913322"", ""source_sha256"": ""e2e6227a743b1146c6e5474f0085f1924a779fc3d225728c51b588cdf63a0c30"", ""source_version"": ""Complete PMC primary full-text HTML; retrieved2026-10-11"", ""title"": ""How Escherichia coli Tolerates Profuse Hydrogen Peroxide Formation by a Catabolic Pathway"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3807432/""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-021_5599cf97e8f1	UniProtKB:P80668	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:24013633		"[{""reference_id"": ""PMID:24013633"", ""source_assertion"": ""FeaB is identified as the cytosolic NAD-linked aldehyde dehydrogenase."", ""source_locator"": ""Introduction, first paragraph; Fig.1A""}]"	"[{""id"": ""PMID:24013633"", ""source_sha256"": ""0533edcd01824ad3bc3e96cd6dd47ec61a2824e2d6e4fef5330a59779a37feae"", ""source_version"": ""Complete PMC primary full-text HTML; retrieved2026-10-11"", ""title"": ""Finely Tuned Regulation of the Aromatic Amine Degradation Pathway in Escherichia coli"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3811602/""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-022_c4c396939fc3	RHEA:21393	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:24013633		"[{""reference_id"": ""PMID:24013633"", ""source_assertion"": ""The pathway description places FeaB-mediated aldehyde oxidation in the cytosol."", ""source_locator"": ""Introduction, first paragraph; Fig.1A""}]"	"[{""id"": ""PMID:24013633"", ""source_sha256"": ""0533edcd01824ad3bc3e96cd6dd47ec61a2824e2d6e4fef5330a59779a37feae"", ""source_version"": ""Complete PMC primary full-text HTML; retrieved2026-10-11"", ""title"": ""Finely Tuned Regulation of the Aromatic Amine Degradation Pathway in Escherichia coli"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3811602/""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-023_1e0110f31091	RHEA:25266	RO:0002413	RHEA:21393	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:2PHENDEG-PWY|PMID:3309152	The shared aldehyde is transferred between cellular compartments; no transporter or transport reaction is inferred.	"[{""reference_id"": ""MetaCyc:2PHENDEG-PWY"", ""source_assertion"": ""AMINEPHEN-RXN precedes PHENDEHYD-RXN through shared phenylacetaldehyde in the exact two-step native pathway."", ""source_locator"": ""Pathway[@frameid=\""2PHENDEG-PWY\""]/reaction-ordering; reaction-layout""}, {""reference_id"": ""PMID:3309152"", ""source_assertion"": ""K-12 converts the amine through phenylacetaldehyde to phenylacetate using successive oxidase and NAD-dependent dehydrogenase activities."", ""source_locator"": ""resultList/result[id=\""3309152\""]/abstractText""}]"	"[{""id"": ""MetaCyc:2PHENDEG-PWY"", ""source_sha256"": ""43d0462352157ff9dc7ea48fffb5a4eb66135afd8b8aa421cb8de4a0f284798b"", ""source_version"": ""MetaCyc22.5 native META frame; retrieved2026-10-11"", ""title"": ""MetaCyc 2PHENDEG-PWY: phenylethylamine degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:2PHENDEG-PWY""}, {""id"": ""PMID:3309152"", ""source_sha256"": ""027066086a6672cd06876bd13421104cb6b860872ba312d8587a26916fa55a45"", ""source_version"": ""Europe PMC core primary-article abstract record; retrieved2026-10-11; digest covers complete six-result JSON response"", ""title"": ""2-Phenylethylamine catabolism by Escherichia coli K12."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/3309152/""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-024_1828741eceb2	RHEA:25266	BFO:0000050	MetaCyc:2PHENDEG-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:2PHENDEG-PWY|MetaCyc:AMINEPHEN-RXN		"[{""reference_id"": ""MetaCyc:2PHENDEG-PWY"", ""source_assertion"": ""The complete native reaction-list includes AMINEPHEN-RXN; its pathway layout selects the left-to-right catabolic direction."", ""source_locator"": ""Pathway[@frameid=\""2PHENDEG-PWY\""]/reaction-list; reaction-layout[Reaction/@frameid=\""AMINEPHEN-RXN\""]""}, {""reference_id"": ""MetaCyc:AMINEPHEN-RXN"", ""source_assertion"": ""The native AMINEPHEN-RXN explicitly unifies this reaction with RHEA:25266."", ""source_locator"": ""Reaction[@frameid=\""AMINEPHEN-RXN\""]/dblink[dblink-db=\""RHEA\"" and dblink-oid=\""25266\""]""}]"	"[{""id"": ""MetaCyc:2PHENDEG-PWY"", ""source_sha256"": ""43d0462352157ff9dc7ea48fffb5a4eb66135afd8b8aa421cb8de4a0f284798b"", ""source_version"": ""MetaCyc22.5 native META frame; retrieved2026-10-11"", ""title"": ""MetaCyc 2PHENDEG-PWY: phenylethylamine degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:2PHENDEG-PWY""}, {""id"": ""MetaCyc:AMINEPHEN-RXN"", ""source_sha256"": ""d53b18dff2d2dccd26ac6dd90c7b8f2b8816a49c0549bfb39b3099e3425adff2"", ""source_version"": ""MetaCyc22.5 native META frame; retrieved2026-10-11"", ""title"": ""MetaCyc AMINEPHEN-RXN: phenylethylamine oxidation reaction"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:AMINEPHEN-RXN""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-025_120b4a83a216	RHEA:21393	BFO:0000050	MetaCyc:2PHENDEG-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:2PHENDEG-PWY|MetaCyc:PHENDEHYD-RXN|RHEA:21393		"[{""reference_id"": ""MetaCyc:2PHENDEG-PWY"", ""source_assertion"": ""The complete native reaction-list includes PHENDEHYD-RXN; its pathway layout selects the left-to-right catabolic direction."", ""source_locator"": ""Pathway[@frameid=\""2PHENDEG-PWY\""]/reaction-list; reaction-layout[Reaction/@frameid=\""PHENDEHYD-RXN\""]""}, {""reference_id"": ""MetaCyc:PHENDEHYD-RXN"", ""source_assertion"": ""The native PHENDEHYD-RXN cross-reference identifies bidirectional RHEA:21395. The reaction object is annotated REVERSIBLE."", ""source_locator"": ""Reaction[@frameid=\""PHENDEHYD-RXN\""]/dblink[dblink-db=\""RHEA\"" and dblink-oid=\""21395\""]; reaction-direction""}, {""reference_id"": ""RHEA:21393"", ""source_assertion"": ""Rhea142 links master RHEA:21392 to both bidirectional RHEA:21395 and forward RHEA:21393, preserving the same underlying reaction."", ""source_locator"": ""http://rdf.rhea-db.org/21392/rh:bidirectionalReaction -> http://rdf.rhea-db.org/21395; rh:directionalReaction -> http://rdf.rhea-db.org/21393""}]"	"[{""id"": ""MetaCyc:2PHENDEG-PWY"", ""source_sha256"": ""43d0462352157ff9dc7ea48fffb5a4eb66135afd8b8aa421cb8de4a0f284798b"", ""source_version"": ""MetaCyc22.5 native META frame; retrieved2026-10-11"", ""title"": ""MetaCyc 2PHENDEG-PWY: phenylethylamine degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:2PHENDEG-PWY""}, {""id"": ""MetaCyc:PHENDEHYD-RXN"", ""source_sha256"": ""6180f594e79c03d173878e114e4d2b5beeca89b859c7700844e767aaa9b1a77c"", ""source_version"": ""MetaCyc22.5 native META frame; retrieved2026-10-11"", ""title"": ""MetaCyc PHENDEHYD-RXN: phenylacetaldehyde dehydrogenase reaction"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PHENDEHYD-RXN""}, {""id"": ""RHEA:21393"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea142; release2026-09-02; digest covers complete native RDF gzip, selected objects identified in source locators"", ""title"": ""Rhea directed reaction 21393"", ""url"": ""https://www.rhea-db.org/rhea/21393""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-026_590f9fbfb3a5	MetaCyc:2PHENDEG-PWY	BFO:0000050	NCBITaxon:83333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:3309152|PMID:9043126	K-12 pathway context supported by specific experimental strains; this does not claim constitutive activity in every K-12 derivative.	"[{""reference_id"": ""PMID:3309152"", ""source_assertion"": ""K-12 cultures use this amine-to-phenylacetate route; PAD-defective mutants lose carbon-source utilization but retain nitrogen-source utilization."", ""source_locator"": ""resultList/result[id=\""3309152\""]/abstractText""}, {""reference_id"": ""PMID:9043126"", ""source_assertion"": ""The K-12 PAD, amine-oxidase and positive-regulator genes were mapped and their pathway roles examined."", ""source_locator"": ""resultList/result[id=\""9043126\""]/abstractText""}]"	"[{""id"": ""PMID:3309152"", ""source_sha256"": ""027066086a6672cd06876bd13421104cb6b860872ba312d8587a26916fa55a45"", ""source_version"": ""Europe PMC core primary-article abstract record; retrieved2026-10-11; digest covers complete six-result JSON response"", ""title"": ""2-Phenylethylamine catabolism by Escherichia coli K12."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/3309152/""}, {""id"": ""PMID:9043126"", ""source_sha256"": ""027066086a6672cd06876bd13421104cb6b860872ba312d8587a26916fa55a45"", ""source_version"": ""Europe PMC core primary-article abstract record; retrieved2026-10-11; digest covers complete six-result JSON response"", ""title"": ""2-phenylethylamine catabolism by Escherichia coli K-12: gene organization and expression."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9043126/""}]"	""
pathwaymech:MetaCyc_2PHENDEG-PWY_phenethylamine-edge-027_1e99973257e0	UniProtKB:Q47129	pathwaymech:regulates	MetaCyc:2PHENDEG-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:24013633|UniProtKB:Q47129	Transcriptional regulation under tested nutrient and inducer conditions, not direct allosteric activation of either enzyme.	"[{""reference_id"": ""UniProtKB:Q47129"", ""source_assertion"": ""FeaR is annotated as a positive regulator of tynA/maoA and feaB/padA expression."", ""source_locator"": ""comments[commentType=\""FUNCTION\""]/texts""}, {""reference_id"": ""PMID:24013633"", ""source_assertion"": ""Under carbon limitation with a pathway inducer, FeaR-dependent transcription activates both tynA and feaB; nitrogen limitation induces tynA without the same feaB response."", ""source_locator"": ""Results, Regulation of the feaB and tynA promoters; Discussion; Fig.9""}]"	"[{""id"": ""PMID:24013633"", ""source_sha256"": ""0533edcd01824ad3bc3e96cd6dd47ec61a2824e2d6e4fef5330a59779a37feae"", ""source_version"": ""Complete PMC primary full-text HTML; retrieved2026-10-11"", ""title"": ""Finely Tuned Regulation of the Aromatic Amine Degradation Pathway in Escherichia coli"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3811602/""}, {""id"": ""UniProtKB:Q47129"", ""source_sha256"": ""08c03accabf3884d2910efade982888bd6d072e56c285e22baf1fbad5aeb8658"", ""source_version"": ""Retrieved2026-10-11; entryVersion 165; sequenceVersion 1; annotation date 2026-09-02"", ""title"": ""UniProtKB Q47129: Transcriptional activator FeaR"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q47129.json""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-001_7fa8d7c2226e	CHEBI:225237	pathwaymech:consumes	RHEA:36724	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:36724		"[{""reference_id"": ""RHEA:36724"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:225237 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/36724/rh:substrates -> http://rdf.rhea-db.org/36723_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_36723_compound_4466/rh:compound -> http://rdf.rhea-db.org/Compound_4466/rh:chebi""}]"	"[{""id"": ""RHEA:36724"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; release 2026-09-02; digest covers complete official RDF gzip; exact selected objects in evidence locators"", ""title"": ""Rhea directed reaction 36724"", ""url"": ""https://www.rhea-db.org/rhea/36724""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-002_fb426a35ab5e	CHEBI:13193	pathwaymech:consumes	RHEA:36724	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:36724		"[{""reference_id"": ""RHEA:36724"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:13193 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/36724/rh:substrates -> http://rdf.rhea-db.org/36723_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_36723_compound_3512/rh:compound -> http://rdf.rhea-db.org/Compound_3512/rh:chebi""}]"	"[{""id"": ""RHEA:36724"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; release 2026-09-02; digest covers complete official RDF gzip; exact selected objects in evidence locators"", ""title"": ""Rhea directed reaction 36724"", ""url"": ""https://www.rhea-db.org/rhea/36724""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-003_29c539980815	CHEBI:15377	pathwaymech:consumes	RHEA:36724	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:36724		"[{""reference_id"": ""RHEA:36724"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:15377 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/36724/rh:substrates -> http://rdf.rhea-db.org/36723_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_36723_compound_1283/rh:compound -> http://rdf.rhea-db.org/Compound_1283/rh:chebi""}]"	"[{""id"": ""RHEA:36724"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; release 2026-09-02; digest covers complete official RDF gzip; exact selected objects in evidence locators"", ""title"": ""Rhea directed reaction 36724"", ""url"": ""https://www.rhea-db.org/rhea/36724""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-004_3e6501b23578	RHEA:36724	pathwaymech:produces	CHEBI:16424	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:36724		"[{""reference_id"": ""RHEA:36724"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:16424 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/36724/rh:products -> http://rdf.rhea-db.org/36723_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_36723_compound_2222/rh:compound -> http://rdf.rhea-db.org/Compound_2222/rh:chebi""}]"	"[{""id"": ""RHEA:36724"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; release 2026-09-02; digest covers complete official RDF gzip; exact selected objects in evidence locators"", ""title"": ""Rhea directed reaction 36724"", ""url"": ""https://www.rhea-db.org/rhea/36724""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-005_e05a2d1dc117	RHEA:36724	pathwaymech:produces	CHEBI:17499	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:36724		"[{""reference_id"": ""RHEA:36724"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:17499 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/36724/rh:products -> http://rdf.rhea-db.org/36723_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_36723_compound_1304/rh:compound -> http://rdf.rhea-db.org/Compound_1304/rh:chebi""}]"	"[{""id"": ""RHEA:36724"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; release 2026-09-02; digest covers complete official RDF gzip; exact selected objects in evidence locators"", ""title"": ""Rhea directed reaction 36724"", ""url"": ""https://www.rhea-db.org/rhea/36724""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-006_4d9dd241dacd	RHEA:36724	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:36724		"[{""reference_id"": ""RHEA:36724"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:28938 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/36724/rh:products -> http://rdf.rhea-db.org/36723_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_36723_compound_1012/rh:compound -> http://rdf.rhea-db.org/Compound_1012/rh:chebi""}]"	"[{""id"": ""RHEA:36724"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; release 2026-09-02; digest covers complete official RDF gzip; exact selected objects in evidence locators"", ""title"": ""Rhea directed reaction 36724"", ""url"": ""https://www.rhea-db.org/rhea/36724""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-007_d4169b431cca	CHEBI:16424	pathwaymech:consumes	RHEA:21393	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21393		"[{""reference_id"": ""RHEA:21393"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:16424 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/21393/rh:substrates -> http://rdf.rhea-db.org/21392_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_21392_compound_2222/rh:compound -> http://rdf.rhea-db.org/Compound_2222/rh:chebi""}]"	"[{""id"": ""RHEA:21393"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; release 2026-09-02; digest covers complete official RDF gzip; exact selected objects in evidence locators"", ""title"": ""Rhea directed reaction 21393"", ""url"": ""https://www.rhea-db.org/rhea/21393""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-008_3587a59e5e86	CHEBI:57540	pathwaymech:consumes	RHEA:21393	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21393		"[{""reference_id"": ""RHEA:21393"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:57540 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/21393/rh:substrates -> http://rdf.rhea-db.org/21392_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_21392_compound_3484/rh:compound -> http://rdf.rhea-db.org/Compound_3484/rh:chebi""}]"	"[{""id"": ""RHEA:21393"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; release 2026-09-02; digest covers complete official RDF gzip; exact selected objects in evidence locators"", ""title"": ""Rhea directed reaction 21393"", ""url"": ""https://www.rhea-db.org/rhea/21393""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-009_62362735ea69	CHEBI:15377	pathwaymech:consumes	RHEA:21393	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21393		"[{""reference_id"": ""RHEA:21393"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:15377 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/21393/rh:substrates -> http://rdf.rhea-db.org/21392_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_21392_compound_1283/rh:compound -> http://rdf.rhea-db.org/Compound_1283/rh:chebi""}]"	"[{""id"": ""RHEA:21393"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; release 2026-09-02; digest covers complete official RDF gzip; exact selected objects in evidence locators"", ""title"": ""Rhea directed reaction 21393"", ""url"": ""https://www.rhea-db.org/rhea/21393""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-010_ee3a2ba9eb4d	RHEA:21393	pathwaymech:produces	CHEBI:18401	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21393		"[{""reference_id"": ""RHEA:21393"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:18401 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/21393/rh:products -> http://rdf.rhea-db.org/21392_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_21392_compound_5243/rh:compound -> http://rdf.rhea-db.org/Compound_5243/rh:chebi""}]"	"[{""id"": ""RHEA:21393"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; release 2026-09-02; digest covers complete official RDF gzip; exact selected objects in evidence locators"", ""title"": ""Rhea directed reaction 21393"", ""url"": ""https://www.rhea-db.org/rhea/21393""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-011_04b390c7f505	RHEA:21393	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21393		"[{""reference_id"": ""RHEA:21393"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:57945 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/21393/rh:products -> http://rdf.rhea-db.org/21392_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_21392_compound_1650/rh:compound -> http://rdf.rhea-db.org/Compound_1650/rh:chebi""}]"	"[{""id"": ""RHEA:21393"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; release 2026-09-02; digest covers complete official RDF gzip; exact selected objects in evidence locators"", ""title"": ""Rhea directed reaction 21393"", ""url"": ""https://www.rhea-db.org/rhea/21393""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-012_216584daab39	RHEA:21393	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21393		"[{""reference_id"": ""RHEA:21393"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:15378 on its products side with coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/21393/rh:products -> http://rdf.rhea-db.org/21392_R/rh:contains2 -> http://rdf.rhea-db.org/Participant_21392_compound_3249/rh:compound -> http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:21393"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; release 2026-09-02; digest covers complete official RDF gzip; exact selected objects in evidence locators"", ""title"": ""Rhea directed reaction 21393"", ""url"": ""https://www.rhea-db.org/rhea/21393""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-013_4a97660f8f34	MetaCyc:CPLX-8088	pathwaymech:catalyzes	RHEA:36724	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8088|MetaCyc:RXN-11510	Source-curated activity association. This does not claim that strain-U complex stoichiometry was measured by purification or crystallography.	"[{""reference_id"": ""MetaCyc:CPLX-8088"", ""source_assertion"": ""The strain-U quinohaemoprotein complex is annotated as the enzyme of ENZRXN-17923, which points to RXN-11510."", ""source_locator"": ""Protein[@frameid=\""CPLX-8088\""]/catalyzes/Enzymatic-Reaction[@frameid=\""ENZRXN-17923\""]/reaction""}, {""reference_id"": ""MetaCyc:RXN-11510"", ""source_assertion"": ""RXN-11510 is explicitly unified with forward RHEA:36724 and is annotated LEFT-TO-RIGHT."", ""source_locator"": ""Reaction[@frameid=\""RXN-11510\""]/dblink[dblink-db=\""RHEA\""]; reaction-direction""}]"	"[{""id"": ""MetaCyc:CPLX-8088"", ""source_sha256"": ""33dbcf6026c2b1c58812c4eaf40aa13e6c54a5e6645862aff4cea432497694cd"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""MetaCyc native CPLX-8088"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8088""}, {""id"": ""MetaCyc:RXN-11510"", ""source_sha256"": ""70461e96d89576e98b7cc21058545ccb3552eb571640d3b6c60745153450a243"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""MetaCyc native RXN-11510"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11510""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-014_81b2673ccf5b	UniProtKB:B1N7H3	pathwaymech:enables	RHEA:21393	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-8089|MetaCyc:MONOMER-15732|MetaCyc:PHENDEHYD-RXN|RHEA:21393	Functional gene-product/activity association only: neither an active isolated monomer nor a fixed PeaE or PeaEFG stoichiometry is asserted. Alternative aldehyde oxidation remains possible.	"[{""reference_id"": ""MetaCyc:CPLX-8089"", ""source_assertion"": ""The native source assigns the strain-U peaE product to NAD-dependent phenylacetaldehyde dehydrogenase activity and reports retained activity and growth after peaE deletion."", ""source_locator"": ""Protein[@frameid=\""CPLX-8089\""]/comment; catalyzes/Enzymatic-Reaction[@frameid=\""ENZRXN-17924\""]/reaction""}, {""reference_id"": ""MetaCyc:MONOMER-15732"", ""source_assertion"": ""The native PeaE polypeptide is explicitly unified with UniProtKB:B1N7H3 and is a component of CPLX-8089."", ""source_locator"": ""Protein[@frameid=\""MONOMER-15732\""]/synonym; component-of; dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""MetaCyc:PHENDEHYD-RXN"", ""source_assertion"": ""PHENDEHYD-RXN is annotated REVERSIBLE and cross-references bidirectional RHEA:21395."", ""source_locator"": ""Reaction[@frameid=\""PHENDEHYD-RXN\""]/reaction-direction; dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:21393"", ""source_assertion"": ""Master RHEA:21392 links to forward RHEA:21393 and bidirectional RHEA:21395."", ""source_locator"": ""http://rdf.rhea-db.org/21392/rh:directionalReaction -> http://rdf.rhea-db.org/21393; rh:bidirectionalReaction -> http://rdf.rhea-db.org/21395""}]"	"[{""id"": ""MetaCyc:CPLX-8089"", ""source_sha256"": ""6e0785aba473c99c6017568475e5449d66aa2d129fc9c924dc14f75db5b6fdd2"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""MetaCyc native CPLX-8089"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8089""}, {""id"": ""MetaCyc:MONOMER-15732"", ""source_sha256"": ""f318ecebc9edb14a0e9fedf83da4091d635d5521a45edb809477288176a7ba6c"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""MetaCyc native MONOMER-15732"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-15732""}, {""id"": ""MetaCyc:PHENDEHYD-RXN"", ""source_sha256"": ""6180f594e79c03d173878e114e4d2b5beeca89b859c7700844e767aaa9b1a77c"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""MetaCyc native PHENDEHYD-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PHENDEHYD-RXN""}, {""id"": ""RHEA:21393"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; release 2026-09-02; digest covers complete official RDF gzip; exact selected objects in evidence locators"", ""title"": ""Rhea directed reaction 21393"", ""url"": ""https://www.rhea-db.org/rhea/21393""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-015_976a0f6da1b6	MetaCyc:CPLX-8088	BFO:0000051	UniProtKB:B1N7H2	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1111/j.1462-2920.2007.01464.x|MetaCyc:CPLX-8088|MetaCyc:MONOMER-15729	Native annotated composition, supported at an in silico/source-curation tier; not direct strain-U structural stoichiometry evidence.	"[{""reference_id"": ""MetaCyc:CPLX-8088"", ""source_assertion"": ""The native complex annotates one MONOMER-15729 component (PeaA); this is a curated composition assignment."", ""source_locator"": ""Protein[@frameid=\""CPLX-8088\""]/component[Protein/@frameid=\""MONOMER-15729\""]/coefficient""}, {""reference_id"": ""MetaCyc:MONOMER-15729"", ""source_assertion"": ""The native polypeptide explicitly unifies MONOMER-15729 with UniProtKB:B1N7H2."", ""source_locator"": ""Protein[@frameid=\""MONOMER-15729\""]/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""DOI:10.1111/j.1462-2920.2007.01464.x"", ""source_assertion"": ""BRENDA describes the strain-U heterotrimer assignment as determined by in silico experiments."", ""source_locator"": ""BRENDA reference 686425; Subunits table; EC 1.4.9.1; heterotrimer row""}]"	"[{""id"": ""DOI:10.1111/j.1462-2920.2007.01464.x"", ""source_sha256"": ""6da47734049206f689948a9e2aa4ab2c1debfc7e09a298c8587745b671cca4a1"", ""source_version"": ""BRENDA release 2026.1 (March 2026), source-specific tables retrieved 2026-10-11; DOI identifies the annotated publication; digest covers the BRENDA HTML, not the paper"", ""title"": ""BRENDA annotations of Arias et al. (2008), reference 686425; not primary full text"", ""url"": ""https://brenda-enzymes.info/literature.php?r=686425""}, {""id"": ""MetaCyc:CPLX-8088"", ""source_sha256"": ""33dbcf6026c2b1c58812c4eaf40aa13e6c54a5e6645862aff4cea432497694cd"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""MetaCyc native CPLX-8088"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8088""}, {""id"": ""MetaCyc:MONOMER-15729"", ""source_sha256"": ""b7475993293736b04d74ada38e67e09c0ed3020b7e3fedb4d7255cfceed0272d"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""MetaCyc native MONOMER-15729"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-15729""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-016_e32f80dd93ad	MetaCyc:CPLX-8088	BFO:0000051	UniProtKB:B1N7G9	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1111/j.1462-2920.2007.01464.x|MetaCyc:CPLX-8088|MetaCyc:MONOMER-15730	Native annotated composition, supported at an in silico/source-curation tier; not direct strain-U structural stoichiometry evidence.	"[{""reference_id"": ""MetaCyc:CPLX-8088"", ""source_assertion"": ""The native complex annotates one MONOMER-15730 component (PeaD); this is a curated composition assignment."", ""source_locator"": ""Protein[@frameid=\""CPLX-8088\""]/component[Protein/@frameid=\""MONOMER-15730\""]/coefficient""}, {""reference_id"": ""MetaCyc:MONOMER-15730"", ""source_assertion"": ""The native polypeptide explicitly unifies MONOMER-15730 with UniProtKB:B1N7G9."", ""source_locator"": ""Protein[@frameid=\""MONOMER-15730\""]/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""DOI:10.1111/j.1462-2920.2007.01464.x"", ""source_assertion"": ""BRENDA describes the strain-U heterotrimer assignment as determined by in silico experiments."", ""source_locator"": ""BRENDA reference 686425; Subunits table; EC 1.4.9.1; heterotrimer row""}]"	"[{""id"": ""DOI:10.1111/j.1462-2920.2007.01464.x"", ""source_sha256"": ""6da47734049206f689948a9e2aa4ab2c1debfc7e09a298c8587745b671cca4a1"", ""source_version"": ""BRENDA release 2026.1 (March 2026), source-specific tables retrieved 2026-10-11; DOI identifies the annotated publication; digest covers the BRENDA HTML, not the paper"", ""title"": ""BRENDA annotations of Arias et al. (2008), reference 686425; not primary full text"", ""url"": ""https://brenda-enzymes.info/literature.php?r=686425""}, {""id"": ""MetaCyc:CPLX-8088"", ""source_sha256"": ""33dbcf6026c2b1c58812c4eaf40aa13e6c54a5e6645862aff4cea432497694cd"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""MetaCyc native CPLX-8088"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8088""}, {""id"": ""MetaCyc:MONOMER-15730"", ""source_sha256"": ""a48905121a64174a3d44784cee1cbc5359d5b45e1a2c0b58a3ab90c97a56dfd7"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""MetaCyc native MONOMER-15730"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-15730""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-017_b045c03a3b7e	MetaCyc:CPLX-8088	BFO:0000051	UniProtKB:B1N7H0	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1111/j.1462-2920.2007.01464.x|MetaCyc:CPLX-8088|MetaCyc:MONOMER-15731	Native annotated composition, supported at an in silico/source-curation tier; not direct strain-U structural stoichiometry evidence.	"[{""reference_id"": ""MetaCyc:CPLX-8088"", ""source_assertion"": ""The native complex annotates one MONOMER-15731 component (PeaC); this is a curated composition assignment."", ""source_locator"": ""Protein[@frameid=\""CPLX-8088\""]/component[Protein/@frameid=\""MONOMER-15731\""]/coefficient""}, {""reference_id"": ""MetaCyc:MONOMER-15731"", ""source_assertion"": ""The native polypeptide explicitly unifies MONOMER-15731 with UniProtKB:B1N7H0."", ""source_locator"": ""Protein[@frameid=\""MONOMER-15731\""]/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""DOI:10.1111/j.1462-2920.2007.01464.x"", ""source_assertion"": ""BRENDA describes the strain-U heterotrimer assignment as determined by in silico experiments."", ""source_locator"": ""BRENDA reference 686425; Subunits table; EC 1.4.9.1; heterotrimer row""}]"	"[{""id"": ""DOI:10.1111/j.1462-2920.2007.01464.x"", ""source_sha256"": ""6da47734049206f689948a9e2aa4ab2c1debfc7e09a298c8587745b671cca4a1"", ""source_version"": ""BRENDA release 2026.1 (March 2026), source-specific tables retrieved 2026-10-11; DOI identifies the annotated publication; digest covers the BRENDA HTML, not the paper"", ""title"": ""BRENDA annotations of Arias et al. (2008), reference 686425; not primary full text"", ""url"": ""https://brenda-enzymes.info/literature.php?r=686425""}, {""id"": ""MetaCyc:CPLX-8088"", ""source_sha256"": ""33dbcf6026c2b1c58812c4eaf40aa13e6c54a5e6645862aff4cea432497694cd"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""MetaCyc native CPLX-8088"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8088""}, {""id"": ""MetaCyc:MONOMER-15731"", ""source_sha256"": ""96be854219f535d970c960ac430520eda2b5c6e2133706ec8ffc70dce293f685"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""MetaCyc native MONOMER-15731"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-15731""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-018_5b6cc8499816	UniProtKB:B1N7H1	pathwaymech:enables	MetaCyc:CPLX-8088	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1111/j.1462-2920.2007.01464.x|MetaCyc:CPLX-8088|UniProtKB:B1N7H1	Accessory activity/maturation requirement; not a fourth structural subunit, an individually sufficient catalyst, or a fully specified maturation reaction.	"[{""reference_id"": ""MetaCyc:CPLX-8088"", ""source_assertion"": ""The native source reports that peaB knockout mutations render the quinohaemoprotein enzyme inactive."", ""source_locator"": ""Protein[@frameid=\""CPLX-8088\""]/comment, second paragraph""}, {""reference_id"": ""UniProtKB:B1N7H1"", ""source_assertion"": ""This sequence entry identifies peaB, protein ABR57203.1, from the strain-U nucleotide-sequence submission associated with PMID18177365."", ""source_locator"": ""genes/geneName; references[citation/id=\""18177365\""]/referenceComments[type=\""STRAIN\""]; uniProtKBCrossReferences[database=\""EMBL\""]""}, {""reference_id"": ""DOI:10.1111/j.1462-2920.2007.01464.x"", ""source_assertion"": ""BRENDA identifies PeaB as needed for correct function and post-translational modification of the gamma subunit, not an interacting component during catalytic turnover."", ""source_locator"": ""BRENDA reference 686425; Subunits table; EC 1.4.9.1; additional information row""}]"	"[{""id"": ""DOI:10.1111/j.1462-2920.2007.01464.x"", ""source_sha256"": ""6da47734049206f689948a9e2aa4ab2c1debfc7e09a298c8587745b671cca4a1"", ""source_version"": ""BRENDA release 2026.1 (March 2026), source-specific tables retrieved 2026-10-11; DOI identifies the annotated publication; digest covers the BRENDA HTML, not the paper"", ""title"": ""BRENDA annotations of Arias et al. (2008), reference 686425; not primary full text"", ""url"": ""https://brenda-enzymes.info/literature.php?r=686425""}, {""id"": ""MetaCyc:CPLX-8088"", ""source_sha256"": ""33dbcf6026c2b1c58812c4eaf40aa13e6c54a5e6645862aff4cea432497694cd"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""MetaCyc native CPLX-8088"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-8088""}, {""id"": ""UniProtKB:B1N7H1"", ""source_sha256"": ""a826c9b6006bb70a5527d20d541f103a3805a1846127d45f88e5463ac5b8de2a"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; full individual JSON retrieved 2026-10-11; not a reviewed experimental catalytic annotation"", ""title"": ""UniProtKB B1N7H1 unreviewed sequence identity"", ""url"": ""https://rest.uniprot.org/uniprotkb/B1N7H1.json""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-019_b1acae3b7f9c	MetaCyc:CPLX-8088	pathwaymech:has_cofactor	CHEBI:20252	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:20252|DOI:10.1111/j.1462-2920.2007.01464.x|MetaCyc:PWY-6534|PMID:22235135	Covalently integrated residue, not a freely consumed metabolite. The free CTQ compound CHEBI:73670 linked by old MetaCyc is not substituted for the bound residue.	"[{""reference_id"": ""MetaCyc:PWY-6534"", ""source_assertion"": ""The native pathway describes its quinohaemoprotein amine dehydrogenase as using cysteine tryptophylquinone (CTQ)."", ""source_locator"": ""Pathway[@frameid=\""PWY-6534\""]/comment, first paragraph""}, {""reference_id"": ""DOI:10.1111/j.1462-2920.2007.01464.x"", ""source_assertion"": ""BRENDA annotates CTQ as a redox cofactor of this enzyme."", ""source_locator"": ""BRENDA reference 686425; Cofactor table; EC 1.4.9.1""}, {""reference_id"": ""CHEBI:20252"", ""source_assertion"": ""ChEBI defines this entity as an amino-acid residue derived from cysteine tryptophylquinone."", ""source_locator"": ""CHEBI:20252; rdfs:label; IAO:0000115""}, {""reference_id"": ""PMID:22235135"", ""source_assertion"": ""The Introduction identifies CTQ as a post-translationally derived gamma-subunit cofactor of QHNDH. The experiments in this paper concern P. denitrificans Pd1222, not strain U."", ""source_locator"": ""PMC3307263; Introduction (sec1), first paragraph; Experimental Procedures (sec2), Materials and Bacterial Strains""}]"	"[{""id"": ""CHEBI:20252"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255; digest covers the full uncompressed SemanticSQL database, not the issuing webpage; exact label/definition locators queried 2026-10-11"", ""title"": ""ChEBI cysteine tryptophylquinone residue"", ""url"": ""https://www.ebi.ac.uk/chebi/CHEBI:20252""}, {""id"": ""DOI:10.1111/j.1462-2920.2007.01464.x"", ""source_sha256"": ""6da47734049206f689948a9e2aa4ab2c1debfc7e09a298c8587745b671cca4a1"", ""source_version"": ""BRENDA release 2026.1 (March 2026), source-specific tables retrieved 2026-10-11; DOI identifies the annotated publication; digest covers the BRENDA HTML, not the paper"", ""title"": ""BRENDA annotations of Arias et al. (2008), reference 686425; not primary full text"", ""url"": ""https://brenda-enzymes.info/literature.php?r=686425""}, {""id"": ""MetaCyc:PWY-6534"", ""source_sha256"": ""9de2bd81bc996b12453b943e2d1f3b46116f2bf6fd54bd332b13fa352f773446"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""MetaCyc native PWY-6534"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6534""}, {""id"": ""PMID:22235135"", ""source_sha256"": ""9edaf848378464c54a850028e66789612dacee793f5b8d32a86f9ba719f569c9"", ""source_version"": ""2012 primary full HTML inspected; used for protein-derived cofactor class and comparative biogenesis scope, not strain-U experimental confirmation; retrieved 2026-10-11"", ""title"": ""An Unusual Subtilisin-like Serine Protease Is Essential for Biogenesis of Quinohemoprotein Amine Dehydrogenase"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3307263/""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-020_d2c8c2a87543	MetaCyc:CPLX-8088	pathwaymech:has_cofactor	CHEBI:30413	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1111/j.1462-2920.2007.01464.x	Source-curated cofactor assignment; generic heme class preserves the unspecified iron oxidation state. No strain-U experimental stoichiometry measurement is claimed.	"[{""reference_id"": ""DOI:10.1111/j.1462-2920.2007.01464.x"", ""source_assertion"": ""BRENDA annotates two hemes acting as redox-active groups in addition to CTQ."", ""source_locator"": ""BRENDA reference 686425; Cofactor table; EC 1.4.9.1; cysteine tryptophylquinone row""}]"	"[{""id"": ""DOI:10.1111/j.1462-2920.2007.01464.x"", ""source_sha256"": ""6da47734049206f689948a9e2aa4ab2c1debfc7e09a298c8587745b671cca4a1"", ""source_version"": ""BRENDA release 2026.1 (March 2026), source-specific tables retrieved 2026-10-11; DOI identifies the annotated publication; digest covers the BRENDA HTML, not the paper"", ""title"": ""BRENDA annotations of Arias et al. (2008), reference 686425; not primary full text"", ""url"": ""https://brenda-enzymes.info/literature.php?r=686425""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-021_8ab4862d46ff	RHEA:36724	BFO:0000050	MetaCyc:PWY-6534	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6534|MetaCyc:RXN-11510		"[{""reference_id"": ""MetaCyc:PWY-6534"", ""source_assertion"": ""The complete native reaction-list includes RXN-11510; its pathway layout selects the left-to-right catabolic direction."", ""source_locator"": ""Pathway[@frameid=\""PWY-6534\""]/reaction-list; reaction-layout[Reaction/@frameid=\""RXN-11510\""]""}, {""reference_id"": ""MetaCyc:RXN-11510"", ""source_assertion"": ""RXN-11510 is explicitly unified with forward RHEA:36724 and is annotated LEFT-TO-RIGHT."", ""source_locator"": ""Reaction[@frameid=\""RXN-11510\""]/dblink[dblink-db=\""RHEA\""]; reaction-direction""}]"	"[{""id"": ""MetaCyc:PWY-6534"", ""source_sha256"": ""9de2bd81bc996b12453b943e2d1f3b46116f2bf6fd54bd332b13fa352f773446"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""MetaCyc native PWY-6534"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6534""}, {""id"": ""MetaCyc:RXN-11510"", ""source_sha256"": ""70461e96d89576e98b7cc21058545ccb3552eb571640d3b6c60745153450a243"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""MetaCyc native RXN-11510"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11510""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-022_f098061b33ed	RHEA:21393	BFO:0000050	MetaCyc:PWY-6534	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PHENDEHYD-RXN|MetaCyc:PWY-6534|RHEA:21393		"[{""reference_id"": ""MetaCyc:PWY-6534"", ""source_assertion"": ""The complete native reaction-list includes PHENDEHYD-RXN; its pathway layout selects the left-to-right catabolic direction."", ""source_locator"": ""Pathway[@frameid=\""PWY-6534\""]/reaction-list; reaction-layout[Reaction/@frameid=\""PHENDEHYD-RXN\""]""}, {""reference_id"": ""MetaCyc:PHENDEHYD-RXN"", ""source_assertion"": ""PHENDEHYD-RXN is annotated REVERSIBLE and cross-references bidirectional RHEA:21395."", ""source_locator"": ""Reaction[@frameid=\""PHENDEHYD-RXN\""]/reaction-direction; dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:21393"", ""source_assertion"": ""Master RHEA:21392 links to forward RHEA:21393 and bidirectional RHEA:21395."", ""source_locator"": ""http://rdf.rhea-db.org/21392/rh:directionalReaction -> http://rdf.rhea-db.org/21393; rh:bidirectionalReaction -> http://rdf.rhea-db.org/21395""}]"	"[{""id"": ""MetaCyc:PHENDEHYD-RXN"", ""source_sha256"": ""6180f594e79c03d173878e114e4d2b5beeca89b859c7700844e767aaa9b1a77c"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""MetaCyc native PHENDEHYD-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PHENDEHYD-RXN""}, {""id"": ""MetaCyc:PWY-6534"", ""source_sha256"": ""9de2bd81bc996b12453b943e2d1f3b46116f2bf6fd54bd332b13fa352f773446"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""MetaCyc native PWY-6534"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6534""}, {""id"": ""RHEA:21393"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; release 2026-09-02; digest covers complete official RDF gzip; exact selected objects in evidence locators"", ""title"": ""Rhea directed reaction 21393"", ""url"": ""https://www.rhea-db.org/rhea/21393""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-023_5b4cc96c014d	RHEA:36724	RO:0002413	RHEA:21393	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6534|RHEA:21393|RHEA:36724		"[{""reference_id"": ""MetaCyc:PWY-6534"", ""source_assertion"": ""The native pathway orders RXN-11510 before PHENDEHYD-RXN through phenylacetaldehyde."", ""source_locator"": ""Pathway[@frameid=\""PWY-6534\""]/reaction-ordering; reaction-layout""}, {""reference_id"": ""RHEA:36724"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:16424 on its products side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/36724/rh:products -> http://rdf.rhea-db.org/36723_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_36723_compound_2222/rh:compound -> http://rdf.rhea-db.org/Compound_2222/rh:chebi""}, {""reference_id"": ""RHEA:21393"", ""source_assertion"": ""The directed Rhea reaction places CHEBI:16424 on its substrates side with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/21393/rh:substrates -> http://rdf.rhea-db.org/21392_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_21392_compound_2222/rh:compound -> http://rdf.rhea-db.org/Compound_2222/rh:chebi""}]"	"[{""id"": ""MetaCyc:PWY-6534"", ""source_sha256"": ""9de2bd81bc996b12453b943e2d1f3b46116f2bf6fd54bd332b13fa352f773446"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""MetaCyc native PWY-6534"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6534""}, {""id"": ""RHEA:21393"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; release 2026-09-02; digest covers complete official RDF gzip; exact selected objects in evidence locators"", ""title"": ""Rhea directed reaction 21393"", ""url"": ""https://www.rhea-db.org/rhea/21393""}, {""id"": ""RHEA:36724"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; release 2026-09-02; digest covers complete official RDF gzip; exact selected objects in evidence locators"", ""title"": ""Rhea directed reaction 36724"", ""url"": ""https://www.rhea-db.org/rhea/36724""}]"	""
pathwaymech:MetaCyc_PWY-6534_phenethylamine-ii-edge-024_7879835541f8	MetaCyc:PWY-6534	BFO:0000050	NCBITaxon:303	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:18177365|UniProtKB:B1N7H2	Strain U is the experimental scope. Species-level identifier does not assert equivalent pathway function in all P. putida strains.	"[{""reference_id"": ""PMID:18177365"", ""source_assertion"": ""The inspected primary abstract reports the strain-U Pea route: phenylethylamine transport, quinohaemoprotein-mediated deamination to phenylacetaldehyde, then oxidation to phenylacetate."", ""source_locator"": ""resultList/result[id=\""18177365\""]/abstractText""}, {""reference_id"": ""UniProtKB:B1N7H2"", ""source_assertion"": ""The sequence entry identifies Pseudomonas putida, NCBI taxon 303, and identifies strain U for the original nucleotide-sequence reference."", ""source_locator"": ""organism/taxonId; references[citation/id=\""18177365\""]/referenceComments[type=\""STRAIN\""]""}]"	"[{""id"": ""PMID:18177365"", ""source_sha256"": ""2d5218643a8514293187873fb131837a290e1e4550ccb1d552cd52d7bf36ded7"", ""source_version"": ""2008 primary publication; inspected Europe PMC core metadata and abstract only, retrieved 2026-10-11"", ""title"": ""Genetic analyses and molecular characterization of the pathways involved in the conversion of 2-phenylethylamine and 2-phenylethanol into phenylacetic acid in Pseudomonas putida U."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18177365&format=json&resultType=core""}, {""id"": ""UniProtKB:B1N7H2"", ""source_sha256"": ""48491bbc422d8d18d56c03408fa8270f8f22a70c723454ac21afdf06263a2d15"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; full individual JSON retrieved 2026-10-11; not a reviewed experimental catalytic annotation"", ""title"": ""UniProtKB B1N7H2 unreviewed sequence identity"", ""url"": ""https://rest.uniprot.org/uniprotkb/B1N7H2.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-001_b0bc7f796076	CHEBI:51057	pathwaymech:consumes	RHEA:20358	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20357	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:20357"", ""source_assertion"": ""RHEA:20358 substrates side 20357_L contains coefficient 1 of Participant_20357_compound_5401; its compound accession is CHEBI:51057."", ""source_locator"": ""http://rdf.rhea-db.org/20358 rh:substrates; http://rdf.rhea-db.org/20357_L rh:contains1 http://rdf.rhea-db.org/Participant_20357_compound_5401; rh:compound http://rdf.rhea-db.org/Compound_5401; rh:accession""}]"	"[{""id"": ""RHEA:20357"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 20357 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-002_a25aa166f706	CHEBI:57945	pathwaymech:consumes	RHEA:20358	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20357	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:20357"", ""source_assertion"": ""RHEA:20358 substrates side 20357_L contains coefficient 1 of Participant_20357_compound_1650; its compound accession is CHEBI:57945."", ""source_locator"": ""http://rdf.rhea-db.org/20358 rh:substrates; http://rdf.rhea-db.org/20357_L rh:contains1 http://rdf.rhea-db.org/Participant_20357_compound_1650; rh:compound http://rdf.rhea-db.org/Compound_1650; rh:accession""}]"	"[{""id"": ""RHEA:20357"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 20357 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-003_ce6008d90916	CHEBI:15379	pathwaymech:consumes	RHEA:20358	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20357	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:20357"", ""source_assertion"": ""RHEA:20358 substrates side 20357_L contains coefficient 1 of Participant_20357_compound_1198; its compound accession is CHEBI:15379."", ""source_locator"": ""http://rdf.rhea-db.org/20358 rh:substrates; http://rdf.rhea-db.org/20357_L rh:contains1 http://rdf.rhea-db.org/Participant_20357_compound_1198; rh:compound http://rdf.rhea-db.org/Compound_1198; rh:accession""}]"	"[{""id"": ""RHEA:20357"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 20357 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-004_7eb1e6b7082b	CHEBI:15378	pathwaymech:consumes	RHEA:20358	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20357	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:20357"", ""source_assertion"": ""RHEA:20358 substrates side 20357_L contains coefficient 1 of Participant_20357_compound_3249; its compound accession is CHEBI:15378."", ""source_locator"": ""http://rdf.rhea-db.org/20358 rh:substrates; http://rdf.rhea-db.org/20357_L rh:contains1 http://rdf.rhea-db.org/Participant_20357_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:20357"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 20357 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-005_d70999c7870a	RHEA:20358	pathwaymech:produces	CHEBI:60087	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:60088|MetaCyc:CARBOXYETHYL-3-5-CYCLOHEXADIENE-1-2-DIOL|RHEA:20357	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained. This is the relative-cis parent, broader than the native absolute-isomer cross-reference.	"[{""reference_id"": ""RHEA:20357"", ""source_assertion"": ""RHEA:20358 products side 20357_R contains coefficient 1 of Participant_20357_compound_6210; its compound accession is CHEBI:60087."", ""source_locator"": ""http://rdf.rhea-db.org/20358 rh:products; http://rdf.rhea-db.org/20357_R rh:contains1 http://rdf.rhea-db.org/Participant_20357_compound_6210; rh:compound http://rdf.rhea-db.org/Compound_6210; rh:accession""}, {""reference_id"": ""MetaCyc:CARBOXYETHYL-3-5-CYCLOHEXADIENE-1-2-DIOL"", ""source_assertion"": ""The native compound cross-references CHEBI:60088 and retains its absolute-isomer InChI. This is narrower than the selected relative-cis Rhea participant."", ""source_locator"": ""Compound[@frameid=\""CARBOXYETHYL-3-5-CYCLOHEXADIENE-1-2-DIOL\""]/dblink[dblink-db=\""CHEBI\""]; inchi""}, {""reference_id"": ""CHEBI:60088"", ""source_assertion"": ""CHEBI:60088 is explicitly a subclass of CHEBI:60087; their identical serialized InChI does not remove the stated absolute versus relative-cis ontology distinction."", ""source_locator"": ""statements: subject CHEBI:60088; rdfs:subClassOf CHEBI:60087; chemrof:inchi_string; rdfs:label""}]"	"[{""id"": ""CHEBI:60088"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete preserved database; exact subject and predicates are specified per assertion"", ""title"": ""ChEBI 255 original Semantic SQL authority: CHEBI:60088"", ""url"": ""https://github.com/INCATools/semantic-sql/releases""}, {""id"": ""MetaCyc:CARBOXYETHYL-3-5-CYCLOHEXADIENE-1-2-DIOL"", ""source_sha256"": ""639c24ac7f55b1e1cdc3b01f690ff52fb3bf0b547d2f7df96f73112265b6939c"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers complete original compound XML"", ""title"": ""MetaCyc CARBOXYETHYL-3-5-CYCLOHEXADIENE-1-2-DIOL original compound structure and cross-references"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CARBOXYETHYL-3-5-CYCLOHEXADIENE-1-2-DIOL""}, {""id"": ""RHEA:20357"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 20357 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-006_1bcbf37fdb90	RHEA:20358	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20357	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:20357"", ""source_assertion"": ""RHEA:20358 products side 20357_R contains coefficient 1 of Participant_20357_compound_3484; its compound accession is CHEBI:57540."", ""source_locator"": ""http://rdf.rhea-db.org/20358 rh:products; http://rdf.rhea-db.org/20357_R rh:contains1 http://rdf.rhea-db.org/Participant_20357_compound_3484; rh:compound http://rdf.rhea-db.org/Compound_3484; rh:accession""}]"	"[{""id"": ""RHEA:20357"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 20357 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-007_c764391556e1	CHEBI:60087	pathwaymech:consumes	RHEA:25063	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:60088|MetaCyc:CARBOXYETHYL-3-5-CYCLOHEXADIENE-1-2-DIOL|RHEA:25062	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained. This is the relative-cis parent, broader than the native absolute-isomer cross-reference.	"[{""reference_id"": ""RHEA:25062"", ""source_assertion"": ""RHEA:25063 substrates side 25062_L contains coefficient 1 of Participant_25062_compound_6210; its compound accession is CHEBI:60087."", ""source_locator"": ""http://rdf.rhea-db.org/25063 rh:substrates; http://rdf.rhea-db.org/25062_L rh:contains1 http://rdf.rhea-db.org/Participant_25062_compound_6210; rh:compound http://rdf.rhea-db.org/Compound_6210; rh:accession""}, {""reference_id"": ""MetaCyc:CARBOXYETHYL-3-5-CYCLOHEXADIENE-1-2-DIOL"", ""source_assertion"": ""The native compound cross-references CHEBI:60088 and retains its absolute-isomer InChI. This is narrower than the selected relative-cis Rhea participant."", ""source_locator"": ""Compound[@frameid=\""CARBOXYETHYL-3-5-CYCLOHEXADIENE-1-2-DIOL\""]/dblink[dblink-db=\""CHEBI\""]; inchi""}, {""reference_id"": ""CHEBI:60088"", ""source_assertion"": ""CHEBI:60088 is explicitly a subclass of CHEBI:60087; their identical serialized InChI does not remove the stated absolute versus relative-cis ontology distinction."", ""source_locator"": ""statements: subject CHEBI:60088; rdfs:subClassOf CHEBI:60087; chemrof:inchi_string; rdfs:label""}]"	"[{""id"": ""CHEBI:60088"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete preserved database; exact subject and predicates are specified per assertion"", ""title"": ""ChEBI 255 original Semantic SQL authority: CHEBI:60088"", ""url"": ""https://github.com/INCATools/semantic-sql/releases""}, {""id"": ""MetaCyc:CARBOXYETHYL-3-5-CYCLOHEXADIENE-1-2-DIOL"", ""source_sha256"": ""639c24ac7f55b1e1cdc3b01f690ff52fb3bf0b547d2f7df96f73112265b6939c"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers complete original compound XML"", ""title"": ""MetaCyc CARBOXYETHYL-3-5-CYCLOHEXADIENE-1-2-DIOL original compound structure and cross-references"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CARBOXYETHYL-3-5-CYCLOHEXADIENE-1-2-DIOL""}, {""id"": ""RHEA:25062"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 25062 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-008_c3ace6a3a61b	CHEBI:57540	pathwaymech:consumes	RHEA:25063	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25062	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:25062"", ""source_assertion"": ""RHEA:25063 substrates side 25062_L contains coefficient 1 of Participant_25062_compound_3484; its compound accession is CHEBI:57540."", ""source_locator"": ""http://rdf.rhea-db.org/25063 rh:substrates; http://rdf.rhea-db.org/25062_L rh:contains1 http://rdf.rhea-db.org/Participant_25062_compound_3484; rh:compound http://rdf.rhea-db.org/Compound_3484; rh:accession""}]"	"[{""id"": ""RHEA:25062"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 25062 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-009_d3ef0322d9bf	RHEA:25063	pathwaymech:produces	CHEBI:46951	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25062	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:25062"", ""source_assertion"": ""RHEA:25063 products side 25062_R contains coefficient 1 of Participant_25062_compound_2958; its compound accession is CHEBI:46951."", ""source_locator"": ""http://rdf.rhea-db.org/25063 rh:products; http://rdf.rhea-db.org/25062_R rh:contains1 http://rdf.rhea-db.org/Participant_25062_compound_2958; rh:compound http://rdf.rhea-db.org/Compound_2958; rh:accession""}]"	"[{""id"": ""RHEA:25062"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 25062 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-010_f94c71ecba62	RHEA:25063	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25062	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:25062"", ""source_assertion"": ""RHEA:25063 products side 25062_R contains coefficient 1 of Participant_25062_compound_1650; its compound accession is CHEBI:57945."", ""source_locator"": ""http://rdf.rhea-db.org/25063 rh:products; http://rdf.rhea-db.org/25062_R rh:contains1 http://rdf.rhea-db.org/Participant_25062_compound_1650; rh:compound http://rdf.rhea-db.org/Compound_1650; rh:accession""}]"	"[{""id"": ""RHEA:25062"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 25062 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-011_82f5d86f96ee	RHEA:25063	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25062	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:25062"", ""source_assertion"": ""RHEA:25063 products side 25062_R contains coefficient 1 of Participant_25062_compound_3249; its compound accession is CHEBI:15378."", ""source_locator"": ""http://rdf.rhea-db.org/25063 rh:products; http://rdf.rhea-db.org/25062_R rh:contains1 http://rdf.rhea-db.org/Participant_25062_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:25062"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 25062 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-012_8e556b79c35b	CHEBI:57277	pathwaymech:consumes	RHEA:24786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24785	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:24785"", ""source_assertion"": ""RHEA:24786 substrates side 24785_L contains coefficient 1 of Participant_24785_compound_5320; its compound accession is CHEBI:57277."", ""source_locator"": ""http://rdf.rhea-db.org/24786 rh:substrates; http://rdf.rhea-db.org/24785_L rh:contains1 http://rdf.rhea-db.org/Participant_24785_compound_5320; rh:compound http://rdf.rhea-db.org/Compound_5320; rh:accession""}]"	"[{""id"": ""RHEA:24785"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 24785 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-013_28ae0497a09d	CHEBI:57945	pathwaymech:consumes	RHEA:24786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24785	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:24785"", ""source_assertion"": ""RHEA:24786 substrates side 24785_L contains coefficient 1 of Participant_24785_compound_1650; its compound accession is CHEBI:57945."", ""source_locator"": ""http://rdf.rhea-db.org/24786 rh:substrates; http://rdf.rhea-db.org/24785_L rh:contains1 http://rdf.rhea-db.org/Participant_24785_compound_1650; rh:compound http://rdf.rhea-db.org/Compound_1650; rh:accession""}]"	"[{""id"": ""RHEA:24785"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 24785 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-014_eb5d45a8103b	CHEBI:15379	pathwaymech:consumes	RHEA:24786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24785	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:24785"", ""source_assertion"": ""RHEA:24786 substrates side 24785_L contains coefficient 1 of Participant_24785_compound_1198; its compound accession is CHEBI:15379."", ""source_locator"": ""http://rdf.rhea-db.org/24786 rh:substrates; http://rdf.rhea-db.org/24785_L rh:contains1 http://rdf.rhea-db.org/Participant_24785_compound_1198; rh:compound http://rdf.rhea-db.org/Compound_1198; rh:accession""}]"	"[{""id"": ""RHEA:24785"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 24785 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-015_d1f596613620	CHEBI:15378	pathwaymech:consumes	RHEA:24786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24785	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:24785"", ""source_assertion"": ""RHEA:24786 substrates side 24785_L contains coefficient 1 of Participant_24785_compound_3249; its compound accession is CHEBI:15378."", ""source_locator"": ""http://rdf.rhea-db.org/24786 rh:substrates; http://rdf.rhea-db.org/24785_L rh:contains1 http://rdf.rhea-db.org/Participant_24785_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:24785"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 24785 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-016_215aa5021df5	RHEA:24786	pathwaymech:produces	CHEBI:46951	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24785	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:24785"", ""source_assertion"": ""RHEA:24786 products side 24785_R contains coefficient 1 of Participant_24785_compound_2958; its compound accession is CHEBI:46951."", ""source_locator"": ""http://rdf.rhea-db.org/24786 rh:products; http://rdf.rhea-db.org/24785_R rh:contains1 http://rdf.rhea-db.org/Participant_24785_compound_2958; rh:compound http://rdf.rhea-db.org/Compound_2958; rh:accession""}]"	"[{""id"": ""RHEA:24785"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 24785 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-017_36e0589e6eeb	RHEA:24786	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24785	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:24785"", ""source_assertion"": ""RHEA:24786 products side 24785_R contains coefficient 1 of Participant_24785_compound_3484; its compound accession is CHEBI:57540."", ""source_locator"": ""http://rdf.rhea-db.org/24786 rh:products; http://rdf.rhea-db.org/24785_R rh:contains1 http://rdf.rhea-db.org/Participant_24785_compound_3484; rh:compound http://rdf.rhea-db.org/Compound_3484; rh:accession""}]"	"[{""id"": ""RHEA:24785"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 24785 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-018_611438cebf24	RHEA:24786	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24785	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:24785"", ""source_assertion"": ""RHEA:24786 products side 24785_R contains coefficient 1 of Participant_24785_compound_1283; its compound accession is CHEBI:15377."", ""source_locator"": ""http://rdf.rhea-db.org/24786 rh:products; http://rdf.rhea-db.org/24785_R rh:contains1 http://rdf.rhea-db.org/Participant_24785_compound_1283; rh:compound http://rdf.rhea-db.org/Compound_1283; rh:accession""}]"	"[{""id"": ""RHEA:24785"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 24785 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-019_4926642ca438	CHEBI:46951	pathwaymech:consumes	RHEA:23841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23840	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:23840"", ""source_assertion"": ""RHEA:23841 substrates side 23840_L contains coefficient 1 of Participant_23840_compound_2958; its compound accession is CHEBI:46951."", ""source_locator"": ""http://rdf.rhea-db.org/23841 rh:substrates; http://rdf.rhea-db.org/23840_L rh:contains1 http://rdf.rhea-db.org/Participant_23840_compound_2958; rh:compound http://rdf.rhea-db.org/Compound_2958; rh:accession""}]"	"[{""id"": ""RHEA:23840"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 23840 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-020_cbac6cb16347	CHEBI:15379	pathwaymech:consumes	RHEA:23841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23840	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:23840"", ""source_assertion"": ""RHEA:23841 substrates side 23840_L contains coefficient 1 of Participant_23840_compound_1198; its compound accession is CHEBI:15379."", ""source_locator"": ""http://rdf.rhea-db.org/23841 rh:substrates; http://rdf.rhea-db.org/23840_L rh:contains1 http://rdf.rhea-db.org/Participant_23840_compound_1198; rh:compound http://rdf.rhea-db.org/Compound_1198; rh:accession""}]"	"[{""id"": ""RHEA:23840"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 23840 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-021_aa54382bd1b4	RHEA:23841	pathwaymech:produces	CHEBI:66887	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:66887|MetaCyc:CPD-157|RHEA:23840	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained. The native compound name and InChI support (2Z,4E); its conflicting (2E,4Z) ChEBI cross-reference is rejected.	"[{""reference_id"": ""RHEA:23840"", ""source_assertion"": ""RHEA:23841 products side 23840_R contains coefficient 1 of Participant_23840_compound_7449; its compound accession is CHEBI:66887."", ""source_locator"": ""http://rdf.rhea-db.org/23841 rh:products; http://rdf.rhea-db.org/23840_R rh:contains1 http://rdf.rhea-db.org/Participant_23840_compound_7449; rh:compound http://rdf.rhea-db.org/Compound_7449; rh:accession""}, {""reference_id"": ""MetaCyc:CPD-157"", ""source_assertion"": ""The native compound name is (2Z,4E) and its InChI ends /b2-1+,7-3-. The separate CHEBI:61449 cross-reference is inconsistent with that structure and is rejected."", ""source_locator"": ""Compound[@frameid=\""CPD-157\""]/common-name; inchi; dblink[dblink-db=\""CHEBI\""]""}, {""reference_id"": ""CHEBI:66887"", ""source_assertion"": ""CHEBI:66887 is (2Z,4E) with the exact native CPD-157 InChI. CHEBI:61449 instead has (2E,4Z) and /b2-1-,7-3+; these are not equivalent structures."", ""source_locator"": ""statements: subjects CHEBI:66887 and CHEBI:61449; chemrof:inchi_string; rdfs:label""}]"	"[{""id"": ""CHEBI:66887"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete preserved database; exact subject and predicates are specified per assertion"", ""title"": ""ChEBI 255 original Semantic SQL authority: CHEBI:66887"", ""url"": ""https://github.com/INCATools/semantic-sql/releases""}, {""id"": ""MetaCyc:CPD-157"", ""source_sha256"": ""3ad16e665855ea03086aa3ee411c0dc56fd242d83ddbd7456f66165130bfb927"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers complete original compound XML"", ""title"": ""MetaCyc CPD-157 original compound structure and cross-references"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-157""}, {""id"": ""RHEA:23840"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 23840 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-022_95601a35bb2e	RHEA:23841	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23840	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:23840"", ""source_assertion"": ""RHEA:23841 products side 23840_R contains coefficient 1 of Participant_23840_compound_3249; its compound accession is CHEBI:15378."", ""source_locator"": ""http://rdf.rhea-db.org/23841 rh:products; http://rdf.rhea-db.org/23840_R rh:contains1 http://rdf.rhea-db.org/Participant_23840_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:23840"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 23840 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-023_7376c09c4ae0	CHEBI:66887	pathwaymech:consumes	RHEA:34188	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:66887|MetaCyc:CPD-157|RHEA:34187	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained. The native compound name and InChI support (2Z,4E); its conflicting (2E,4Z) ChEBI cross-reference is rejected.	"[{""reference_id"": ""RHEA:34187"", ""source_assertion"": ""RHEA:34188 substrates side 34187_L contains coefficient 1 of Participant_34187_compound_7449; its compound accession is CHEBI:66887."", ""source_locator"": ""http://rdf.rhea-db.org/34188 rh:substrates; http://rdf.rhea-db.org/34187_L rh:contains1 http://rdf.rhea-db.org/Participant_34187_compound_7449; rh:compound http://rdf.rhea-db.org/Compound_7449; rh:accession""}, {""reference_id"": ""MetaCyc:CPD-157"", ""source_assertion"": ""The native compound name is (2Z,4E) and its InChI ends /b2-1+,7-3-. The separate CHEBI:61449 cross-reference is inconsistent with that structure and is rejected."", ""source_locator"": ""Compound[@frameid=\""CPD-157\""]/common-name; inchi; dblink[dblink-db=\""CHEBI\""]""}, {""reference_id"": ""CHEBI:66887"", ""source_assertion"": ""CHEBI:66887 is (2Z,4E) with the exact native CPD-157 InChI. CHEBI:61449 instead has (2E,4Z) and /b2-1-,7-3+; these are not equivalent structures."", ""source_locator"": ""statements: subjects CHEBI:66887 and CHEBI:61449; chemrof:inchi_string; rdfs:label""}]"	"[{""id"": ""CHEBI:66887"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete preserved database; exact subject and predicates are specified per assertion"", ""title"": ""ChEBI 255 original Semantic SQL authority: CHEBI:66887"", ""url"": ""https://github.com/INCATools/semantic-sql/releases""}, {""id"": ""MetaCyc:CPD-157"", ""source_sha256"": ""3ad16e665855ea03086aa3ee411c0dc56fd242d83ddbd7456f66165130bfb927"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers complete original compound XML"", ""title"": ""MetaCyc CPD-157 original compound structure and cross-references"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-157""}, {""id"": ""RHEA:34187"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 34187 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-024_816f480bdd9b	CHEBI:15377	pathwaymech:consumes	RHEA:34188	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34187	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:34187"", ""source_assertion"": ""RHEA:34188 substrates side 34187_L contains coefficient 1 of Participant_34187_compound_1283; its compound accession is CHEBI:15377."", ""source_locator"": ""http://rdf.rhea-db.org/34188 rh:substrates; http://rdf.rhea-db.org/34187_L rh:contains1 http://rdf.rhea-db.org/Participant_34187_compound_1283; rh:compound http://rdf.rhea-db.org/Compound_1283; rh:accession""}]"	"[{""id"": ""RHEA:34187"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 34187 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-025_95fbb2a7042c	RHEA:34188	pathwaymech:produces	CHEBI:67152	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34187	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:34187"", ""source_assertion"": ""RHEA:34188 products side 34187_R contains coefficient 1 of Participant_34187_compound_7450; its compound accession is CHEBI:67152."", ""source_locator"": ""http://rdf.rhea-db.org/34188 rh:products; http://rdf.rhea-db.org/34187_R rh:contains1 http://rdf.rhea-db.org/Participant_34187_compound_7450; rh:compound http://rdf.rhea-db.org/Compound_7450; rh:accession""}]"	"[{""id"": ""RHEA:34187"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 34187 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-026_4d8be6f45d6a	RHEA:34188	pathwaymech:produces	CHEBI:30031	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34187	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:34187"", ""source_assertion"": ""RHEA:34188 products side 34187_R contains coefficient 1 of Participant_34187_compound_2501; its compound accession is CHEBI:30031."", ""source_locator"": ""http://rdf.rhea-db.org/34188 rh:products; http://rdf.rhea-db.org/34187_R rh:contains1 http://rdf.rhea-db.org/Participant_34187_compound_2501; rh:compound http://rdf.rhea-db.org/Compound_2501; rh:accession""}]"	"[{""id"": ""RHEA:34187"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 34187 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-027_6914767f8871	RHEA:34188	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34187	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:34187"", ""source_assertion"": ""RHEA:34188 products side 34187_R contains coefficient 1 of Participant_34187_compound_3249; its compound accession is CHEBI:15378."", ""source_locator"": ""http://rdf.rhea-db.org/34188 rh:products; http://rdf.rhea-db.org/34187_R rh:contains1 http://rdf.rhea-db.org/Participant_34187_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:34187"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 34187 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-028_49786a9bb58c	CHEBI:67152	pathwaymech:consumes	RHEA:22582	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22580	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:22580"", ""source_assertion"": ""RHEA:22582 substrates side 22580_R contains coefficient 1 of Participant_22580_compound_7450; its compound accession is CHEBI:67152."", ""source_locator"": ""http://rdf.rhea-db.org/22582 rh:substrates; http://rdf.rhea-db.org/22580_R rh:contains1 http://rdf.rhea-db.org/Participant_22580_compound_7450; rh:compound http://rdf.rhea-db.org/Compound_7450; rh:accession""}]"	"[{""id"": ""RHEA:22580"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 22580 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-029_ddb431582a09	CHEBI:15377	pathwaymech:consumes	RHEA:22582	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22580	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:22580"", ""source_assertion"": ""RHEA:22582 substrates side 22580_R contains coefficient 1 of Participant_22580_compound_1283; its compound accession is CHEBI:15377."", ""source_locator"": ""http://rdf.rhea-db.org/22582 rh:substrates; http://rdf.rhea-db.org/22580_R rh:contains1 http://rdf.rhea-db.org/Participant_22580_compound_1283; rh:compound http://rdf.rhea-db.org/Compound_1283; rh:accession""}]"	"[{""id"": ""RHEA:22580"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 22580 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-030_6f40ce9914d3	RHEA:22582	pathwaymech:produces	CHEBI:73143	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9758851|RHEA:22580	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained. The S assignment is curated; the inspected 1998 aldolase experiment called this configuration presumptive.	"[{""reference_id"": ""RHEA:22580"", ""source_assertion"": ""RHEA:22582 products side 22580_L contains coefficient 1 of Participant_22580_compound_7920; its compound accession is CHEBI:73143."", ""source_locator"": ""http://rdf.rhea-db.org/22582 rh:products; http://rdf.rhea-db.org/22580_L rh:contains1 http://rdf.rhea-db.org/Participant_22580_compound_7920; rh:compound http://rdf.rhea-db.org/Compound_7920; rh:accession""}, {""reference_id"": ""PMID:9758851"", ""source_assertion"": ""The partially purified K-12 aldolase used one substrate enantiomer, called presumably 4S on the basis of the preceding hydratase. The exact absolute assignment was inferred in this experiment."", ""source_locator"": ""Full article, concluding paragraph""}]"	"[{""id"": ""PMID:9758851"", ""source_sha256"": ""3be984ba075dda83caf70b3ad4624872123134d6ac046a765d77c477ea3536ea"", ""source_version"": ""Original primary full article HTML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""Substrate selectivity and biochemical properties of 4-hydroxy-2-keto-pentanoic acid aldolase from Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC106610/""}, {""id"": ""RHEA:22580"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 22580 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-031_2a4e717c586b	CHEBI:73143	pathwaymech:consumes	RHEA:22625	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9758851|RHEA:22624	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained. The S assignment is curated; the inspected 1998 aldolase experiment called this configuration presumptive.	"[{""reference_id"": ""RHEA:22624"", ""source_assertion"": ""RHEA:22625 substrates side 22624_L contains coefficient 1 of Participant_22624_compound_7920; its compound accession is CHEBI:73143."", ""source_locator"": ""http://rdf.rhea-db.org/22625 rh:substrates; http://rdf.rhea-db.org/22624_L rh:contains1 http://rdf.rhea-db.org/Participant_22624_compound_7920; rh:compound http://rdf.rhea-db.org/Compound_7920; rh:accession""}, {""reference_id"": ""PMID:9758851"", ""source_assertion"": ""The partially purified K-12 aldolase used one substrate enantiomer, called presumably 4S on the basis of the preceding hydratase. The exact absolute assignment was inferred in this experiment."", ""source_locator"": ""Full article, concluding paragraph""}]"	"[{""id"": ""PMID:9758851"", ""source_sha256"": ""3be984ba075dda83caf70b3ad4624872123134d6ac046a765d77c477ea3536ea"", ""source_version"": ""Original primary full article HTML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""Substrate selectivity and biochemical properties of 4-hydroxy-2-keto-pentanoic acid aldolase from Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC106610/""}, {""id"": ""RHEA:22624"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 22624 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-032_774a52bc461f	RHEA:22625	pathwaymech:produces	CHEBI:15343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22624	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:22624"", ""source_assertion"": ""RHEA:22625 products side 22624_R contains coefficient 1 of Participant_22624_compound_3952; its compound accession is CHEBI:15343."", ""source_locator"": ""http://rdf.rhea-db.org/22625 rh:products; http://rdf.rhea-db.org/22624_R rh:contains1 http://rdf.rhea-db.org/Participant_22624_compound_3952; rh:compound http://rdf.rhea-db.org/Compound_3952; rh:accession""}]"	"[{""id"": ""RHEA:22624"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 22624 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-033_7d2d2739bc98	RHEA:22625	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22624	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:22624"", ""source_assertion"": ""RHEA:22625 products side 22624_R contains coefficient 1 of Participant_22624_compound_3719; its compound accession is CHEBI:15361."", ""source_locator"": ""http://rdf.rhea-db.org/22625 rh:products; http://rdf.rhea-db.org/22624_R rh:contains1 http://rdf.rhea-db.org/Participant_22624_compound_3719; rh:compound http://rdf.rhea-db.org/Compound_3719; rh:accession""}]"	"[{""id"": ""RHEA:22624"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 22624 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-034_5884691b737f	CHEBI:15343	pathwaymech:consumes	RHEA:23289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23288	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:23288"", ""source_assertion"": ""RHEA:23289 substrates side 23288_L contains coefficient 1 of Participant_23288_compound_3952; its compound accession is CHEBI:15343."", ""source_locator"": ""http://rdf.rhea-db.org/23289 rh:substrates; http://rdf.rhea-db.org/23288_L rh:contains1 http://rdf.rhea-db.org/Participant_23288_compound_3952; rh:compound http://rdf.rhea-db.org/Compound_3952; rh:accession""}]"	"[{""id"": ""RHEA:23288"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 23288 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-035_03709c5caf5e	CHEBI:57540	pathwaymech:consumes	RHEA:23289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23288	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:23288"", ""source_assertion"": ""RHEA:23289 substrates side 23288_L contains coefficient 1 of Participant_23288_compound_3484; its compound accession is CHEBI:57540."", ""source_locator"": ""http://rdf.rhea-db.org/23289 rh:substrates; http://rdf.rhea-db.org/23288_L rh:contains1 http://rdf.rhea-db.org/Participant_23288_compound_3484; rh:compound http://rdf.rhea-db.org/Compound_3484; rh:accession""}]"	"[{""id"": ""RHEA:23288"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 23288 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-036_24dfb4c4b351	CHEBI:57287	pathwaymech:consumes	RHEA:23289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23288	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:23288"", ""source_assertion"": ""RHEA:23289 substrates side 23288_L contains coefficient 1 of Participant_23288_compound_1264; its compound accession is CHEBI:57287."", ""source_locator"": ""http://rdf.rhea-db.org/23289 rh:substrates; http://rdf.rhea-db.org/23288_L rh:contains1 http://rdf.rhea-db.org/Participant_23288_compound_1264; rh:compound http://rdf.rhea-db.org/Compound_1264; rh:accession""}]"	"[{""id"": ""RHEA:23288"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 23288 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-037_5ade84dc341e	RHEA:23289	pathwaymech:produces	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23288	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:23288"", ""source_assertion"": ""RHEA:23289 products side 23288_R contains coefficient 1 of Participant_23288_compound_4271; its compound accession is CHEBI:57288."", ""source_locator"": ""http://rdf.rhea-db.org/23289 rh:products; http://rdf.rhea-db.org/23288_R rh:contains1 http://rdf.rhea-db.org/Participant_23288_compound_4271; rh:compound http://rdf.rhea-db.org/Compound_4271; rh:accession""}]"	"[{""id"": ""RHEA:23288"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 23288 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-038_b63fa358c08f	RHEA:23289	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23288	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:23288"", ""source_assertion"": ""RHEA:23289 products side 23288_R contains coefficient 1 of Participant_23288_compound_1650; its compound accession is CHEBI:57945."", ""source_locator"": ""http://rdf.rhea-db.org/23289 rh:products; http://rdf.rhea-db.org/23288_R rh:contains1 http://rdf.rhea-db.org/Participant_23288_compound_1650; rh:compound http://rdf.rhea-db.org/Compound_1650; rh:accession""}]"	"[{""id"": ""RHEA:23288"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 23288 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-039_03ee84a36208	RHEA:23289	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23288	Coefficient 1 in the selected Rhea 142 catabolic direction; the stated charge and stereochemical scope are retained.	"[{""reference_id"": ""RHEA:23288"", ""source_assertion"": ""RHEA:23289 products side 23288_R contains coefficient 1 of Participant_23288_compound_3249; its compound accession is CHEBI:15378."", ""source_locator"": ""http://rdf.rhea-db.org/23289 rh:products; http://rdf.rhea-db.org/23288_R rh:contains1 http://rdf.rhea-db.org/Participant_23288_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249; rh:accession""}]"	"[{""id"": ""RHEA:23288"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 23288 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-040_a8e5d9a6d5e9	MetaCyc:HCAMULTI-CPLX	pathwaymech:enables	RHEA:20358	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HCAMULTI-CPLX|PMID:9603882|UniProtKB:P0ABR5	The putative four-component Hca system enables the net dioxygenation. Genetics and whole-cell conversion support the system; isolated complex catalysis and component stoichiometry were not established in the inspected work.	"[{""reference_id"": ""MetaCyc:HCAMULTI-CPLX"", ""source_assertion"": ""The native hcaCDEF complex catalyzes HCAMULTI-RXN but its comment explicitly says the dioxygenase has not been biochemically characterized."", ""source_locator"": ""Protein[@frameid=\""HCAMULTI-CPLX\""]/catalyzes; comment""}, {""reference_id"": ""UniProtKB:P0ABR5"", ""source_assertion"": ""HcaE is part of the multicomponent system; its catalytic annotation cross-references RHEA:20357. The source describes HcaE, HcaF, HcaC and HcaD roles."", ""source_locator"": ""comments[0]; comments[1]/reaction; comments[6]""}, {""reference_id"": ""PMID:9603882"", ""source_assertion"": ""K-12 hca mutant complementation and resting-cell HPLC support conversion of phenylpropionate to DHPP; the four component functions were assigned using sequence comparisons."", ""source_locator"": ""Results, cloning of hca and structural analysis of the hca gene cluster; Table 2""}]"	"[{""id"": ""MetaCyc:HCAMULTI-CPLX"", ""source_sha256"": ""08b325ced327dd86fa1f272b7e375ca84576601105eb5884c3d58736444b9cc1"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAMULTI-CPLX original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAMULTI-CPLX""}, {""id"": ""PMID:9603882"", ""source_sha256"": ""77422a1136f6f1891af5f8464bf04eb263715f8e39b0eecbd6f59fd912bc0b53"", ""source_version"": ""Original primary full article HTML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC107259/""}, {""id"": ""UniProtKB:P0ABR5"", ""source_sha256"": ""08176c230f3b4a248de3364416a47222d604fa3ee17abcd31de7a61b8bb06b62"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""3-phenylpropionate/cinnamic acid dioxygenase subunit alpha — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABR5.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-041_1677d233048d	UniProtKB:P0CI31	pathwaymech:enables	RHEA:25063	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PHENPRODIOLDEHYDROG-MONOMER|PMID:9603882|UniProtKB:P0CI31	HcaB is assigned the dihydrodiol dehydrogenase role by current reviewed annotation, genetics and homology. The cited 1998 study explicitly did not demonstrate HcaB activity in isolation; monomer sufficiency is not established.	"[{""reference_id"": ""UniProtKB:P0CI31"", ""source_assertion"": ""The entry assigns RHEA:25062 and cites PMID:9603882; its function carries both similarity and experimental evidence codes. The primary limitation must qualify the catalytic attribution."", ""source_locator"": ""comments[0]; comments[1]/reaction""}, {""quote"": ""the HcaB activity per se has not been demonstrated."", ""reference_id"": ""PMID:9603882"", ""source_locator"": ""Results and Discussion, Regulation of the hca cluster, second paragraph beginning To study the regulation of the hca cluster""}, {""reference_id"": ""MetaCyc:PHENPRODIOLDEHYDROG-MONOMER"", ""source_assertion"": ""The native hcaB gene product is linked to PHENPRODIOLDEHYDROG-RXN; its comment assigns function by sequence and says the enzyme has not been biochemically characterized."", ""source_locator"": ""Protein[@frameid=\""PHENPRODIOLDEHYDROG-MONOMER\""]/catalyzes; comment""}]"	"[{""id"": ""MetaCyc:PHENPRODIOLDEHYDROG-MONOMER"", ""source_sha256"": ""4e0b10e37694be1fa8e2cfc601510da6c9107cf50c2047536a70cd76a44aa51c"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc PHENPRODIOLDEHYDROG-MONOMER original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PHENPRODIOLDEHYDROG-MONOMER""}, {""id"": ""PMID:9603882"", ""source_sha256"": ""77422a1136f6f1891af5f8464bf04eb263715f8e39b0eecbd6f59fd912bc0b53"", ""source_version"": ""Original primary full article HTML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC107259/""}, {""id"": ""UniProtKB:P0CI31"", ""source_sha256"": ""9b618218be8c09f848618235dad859de51868fac85360ce2cf2ce153f2509b3b"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0CI31.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-042_edf23358d74b	UniProtKB:P77397	pathwaymech:enables	RHEA:24786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:MHPHYDROXY-MONOMER|PMID:31811039|PMID:9098055|UniProtKB:P77397	MhpA supplies the hydroxyphenylpropanoate entry activity. W3110 deletion/complementation and purified C-terminal His-tagged protein establish 3HPP hydroxylation to DHPP. NADH and NADPH both support activity; this graph retains the native/current Rhea NADH equation without implying exclusive donor use. The purified construct had an apparent 669-kDa polymeric mass, but its subunit stoichiometry remains unresolved; enables does not assert monomer sufficiency.	"[{""reference_id"": ""UniProtKB:P77397"", ""source_assertion"": ""MhpA is assigned the hydroxylation reaction RHEA:24785; its function cites PMID:9603882."", ""source_locator"": ""comments[0]; comments[1]/reaction""}, {""reference_id"": ""PMID:9098055"", ""source_assertion"": ""Figure 1 identifies MhpA as the first enzyme of the MHP branch; the K-12 cluster study used complementation and sequence comparisons. MC4100 carries a deletion affecting mhp genes."", ""source_locator"": ""Original PDF printed pp. 2574-2578; Figure 1; Table 2 and its Results text""}, {""reference_id"": ""MetaCyc:MHPHYDROXY-MONOMER"", ""source_assertion"": ""The preserved MetaCyc 22.5 protein is linked to MHPHYDROXY-RXN; its historical comment says the hydroxylase was not biochemically characterized. The later direct characterization is cited separately."", ""source_locator"": ""Protein[@frameid=\""MHPHYDROXY-MONOMER\""]/catalyzes; comment""}, {""reference_id"": ""UniProtKB:P77397"", ""source_assertion"": ""The current P77397 entry cross-references EMBL D86239 with ProteinId BAA13052.1, explicitly linking the K-12 protein to the BAA13052 accession identified in the primary study."", ""source_locator"": ""uniProtKBCrossReferences[0]/id; uniProtKBCrossReferences[0]/properties[0]""}, {""reference_id"": ""PMID:31811039"", ""source_assertion"": ""W3110 mhpA deletion abolishes growth on 3HPP but not DHPP; complementation restores it. Purified W3110-derived His-tagged MhpA converts 3HPP to DHPP with NADH, verified by HPLC time course and LC-MS."", ""source_locator"": ""HTML sections s2.1 and s2.3; Figures 2, 4 and 5; Methods s4.4 and s4.6""}, {""reference_id"": ""PMID:31811039"", ""source_assertion"": ""Purified MhpA uses both NADH and NADPH: specific activities are 0.94 and 0.61 U/mg, respectively, with similar measured Km and kcat values. The experiment therefore does not establish exclusive NADH dependence."", ""source_locator"": ""HTML section s2.4, first paragraph; Table 2; Methods s4.5""}, {""reference_id"": ""PMID:31811039"", ""source_assertion"": ""W3110-derived MhpA expressed as a C-terminal His-tagged protein has an approximately 61-kDa polypeptide and apparent 669-kDa SEC mass, interpreted as a likely polymer. These measurements do not establish a fixed subunit count."", ""source_locator"": ""HTML section s2.2; Figure 3C; Methods s4.4 and s4.8""}]"	"[{""id"": ""MetaCyc:MHPHYDROXY-MONOMER"", ""source_sha256"": ""1f78cf2ab8a1919398c87394d21c626afc2291c4abcd26d7aa043919611f78fa"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc MHPHYDROXY-MONOMER original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MHPHYDROXY-MONOMER""}, {""id"": ""PMID:31811039"", ""source_sha256"": ""f580c01b6ef803b4d27e8832e74117624c7b831e106a121447f3b037c9f0cc38"", ""source_version"": ""Original 2020 primary full article HTML (online December 2019); retrieved 2026-10-11; digest covers complete original response body"", ""title"": ""MhpA Is a Hydroxylase Catalyzing the Initial Reaction of 3-(3-Hydroxyphenyl)Propionate Catabolism in Escherichia coli K-12"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC6997738/""}, {""id"": ""PMID:9098055"", ""source_sha256"": ""d3d0addea29699950c3fbaaa608787101e2bd48acb450aa1b58093d67574c49b"", ""source_version"": ""Original primary full article PDF; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12."", ""url"": ""https://europepmc.org/articles/PMC179006?pdf=render""}, {""id"": ""UniProtKB:P77397"", ""source_sha256"": ""b76888f77edc2ab6c759fe2c02e75b96f23b96eec3b4de9885454e99bb4fe376"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77397.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-043_47870054b24a	MetaCyc:DHPDIOXYGEN-CPLX	pathwaymech:catalyzes	RHEA:23841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DHPDIOXYGEN-CPLX|PMID:8399388|UniProtKB:P0ABR9	Tetrameric MhpB catalyzes oxidative ring cleavage. The primary purified-enzyme study supports activity and iron dependence; current curated chemistry specifies the (2Z,4E) product.	"[{""reference_id"": ""MetaCyc:DHPDIOXYGEN-CPLX"", ""source_assertion"": ""The complex contains four DHPDIOXYGEN-MONOMER subunits and is linked to 1.13.11.16-RXN."", ""source_locator"": ""Protein[@frameid=\""DHPDIOXYGEN-CPLX\""]/component; catalyzes""}, {""reference_id"": ""UniProtKB:P0ABR9"", ""source_assertion"": ""The reviewed catalytic activity is RHEA:23840, with the (2Z,4E) product CHEBI:66887 and experimental evidence annotations."", ""source_locator"": ""comments[1]/reaction""}, {""reference_id"": ""PMID:8399388"", ""source_assertion"": ""Purified E. coli MhpB cleaves dihydroxyphenylpropionate; its apparent subunit and native masses were 36 and 134 kDa, and apoenzyme activity was restored by Fe(II) plus ascorbate."", ""source_locator"": ""Europe PMC resultList/result[0]/abstractText""}]"	"[{""id"": ""MetaCyc:DHPDIOXYGEN-CPLX"", ""source_sha256"": ""da22d52b702153fbea03114f3d52c2f306f866e87ca569c0e3adf98f2d0188e0"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc DHPDIOXYGEN-CPLX original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHPDIOXYGEN-CPLX""}, {""id"": ""PMID:8399388"", ""source_sha256"": ""3e376435e76bcbe0438593806f21ae50a0a260986c602f9d32308f0a8b7d10de"", ""source_version"": ""Europe PMC indexed primary abstract and metadata only; retrieved 2026-10-11; digest covers the complete JSON response"", ""title"": ""Overproduction, purification and properties of 2,3-dihydroxyphenylpropionate 1,2-dioxygenase from Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8399388%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P0ABR9"", ""source_sha256"": ""45eaf1fdb8bbab73ae322e69cb920426d6a70dfaca01ae4854758b74d7a5091a"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABR9.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-044_e5eff2e62402	MetaCyc:CPLX0-7950	pathwaymech:catalyzes	RHEA:34188	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7950|PMID:9315862|UniProtKB:P77044	Dimeric MhpC cleaves the ring-fission dienol to succinate and hydroxypentadienoate. Its canonical native complex name also mentions the triene substrate; only the saturated-route dienol reaction is included.	"[{""reference_id"": ""MetaCyc:CPLX0-7950"", ""source_assertion"": ""The complex contains two MHPCHYDROL-MONOMER subunits and is linked to MHPCHYDROL-RXN."", ""source_locator"": ""Protein[@frameid=\""CPLX0-7950\""]/component; catalyzes""}, {""reference_id"": ""UniProtKB:P77044"", ""source_assertion"": ""The current dienol hydrolase activity is RHEA:34187, with succinate and (2Z)-2-hydroxypentadienoate products; the separate triene reaction is a different annotation."", ""source_locator"": ""comments[1]/reaction; comments[2]/reaction""}, {""reference_id"": ""PMID:9315862"", ""source_assertion"": ""Purified MhpC is a dimeric 29-kDa-subunit protein requiring no cofactors in the assay; isotope experiments support replacement of the succinyl group by a solvent proton."", ""source_locator"": ""Europe PMC resultList/result[0]/abstractText""}]"	"[{""id"": ""MetaCyc:CPLX0-7950"", ""source_sha256"": ""3d4bd268bc14f0d3d059219f1670b09a333fdd68b938fc1e3085512c9872cdf6"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc CPLX0-7950 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7950""}, {""id"": ""PMID:9315862"", ""source_sha256"": ""4e8aeba6ea2ad1bf5fe8c701c7ffde66b242295eab7e1536ad45b101bc218d0c"", ""source_version"": ""Europe PMC indexed primary abstract and metadata only; retrieved 2026-10-11; digest covers the complete JSON response"", ""title"": ""Purification, characterization, and stereochemical analysis of a C-C hydrolase: 2-hydroxy-6-keto-nona-2,4-diene-1,9-dioic acid 5,6-hydrolase."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9315862%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P77044"", ""source_sha256"": ""144f8f0fcf04eafe52ccf3c5f6efec27846b721b3df3c9afaf3799aa2d38b421"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77044.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-045_c86f9c156bb4	MetaCyc:CPLX0-7951	pathwaymech:catalyzes	RHEA:22582	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7951|PMID:20053352|PMID:9492273|UniProtKB:P77608	Pentameric MhpD hydrates the dienol in the selected right-to-left Rhea direction. The opposite written master equation does not change the catabolic flow. Low-pH phosphate/sulfate-induced 60-subunit cages are not the constitutive pathway assembly.	"[{""reference_id"": ""MetaCyc:CPLX0-7951"", ""source_assertion"": ""The native enzyme contains five MHPDHYDROL-MONOMER subunits and catalyzes 2-OXOPENT-4-ENOATE-HYDRATASE-RXN."", ""source_locator"": ""Protein[@frameid=\""CPLX0-7951\""]/component; catalyzes""}, {""reference_id"": ""UniProtKB:P77608"", ""source_assertion"": ""The entry assigns RHEA:22580 and describes conversion of the dienol to hydroxyketopentanoate."", ""source_locator"": ""comments[0]; comments[1]/reaction""}, {""reference_id"": ""PMID:9492273"", ""source_assertion"": ""Purified E. coli hydratase uses the dienol tautomer, requires a divalent metal and has maximal activity with Mn(II); HPLC confirmed hydroxyketopentanoate."", ""source_locator"": ""Europe PMC resultList/result[0]/abstractText""}, {""reference_id"": ""PMID:20053352"", ""source_assertion"": ""The primary abstract calls MhpD pentameric; at low pH with phosphate or sulfate it assembles into a 60-subunit cage. This is a specific assembly condition."", ""source_locator"": ""Europe PMC resultList/result[0]/abstractText""}]"	"[{""id"": ""MetaCyc:CPLX0-7951"", ""source_sha256"": ""3b234216eaa5a79eecaef39045f4feeab5ef672bb3c5566c76c65e7aa3c57f53"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc CPLX0-7951 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7951""}, {""id"": ""PMID:20053352"", ""source_sha256"": ""586c189c7ac67601c27fd907c9c4bc246cce9ef803f3d8edf11d6ae4190a868a"", ""source_version"": ""Europe PMC indexed primary abstract and metadata only; retrieved 2026-10-11; digest covers the complete JSON response"", ""title"": ""Assembly of a 20-nm protein cage by Escherichia coli 2-hydroxypentadienoic acid hydratase."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20053352%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""PMID:9492273"", ""source_sha256"": ""8011ab21cbc52ba40baa5ed1b055928dab5db9e4ddb9ca89d722968bd5259750"", ""source_version"": ""Europe PMC indexed primary abstract and metadata only; retrieved 2026-10-11; digest covers the complete JSON response"", ""title"": ""Purification, characterisation and reaction mechanism of monofunctional 2-hydroxypentadienoic acid hydratase from Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9492273%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P77608"", ""source_sha256"": ""0a121eab4c62110bde416cbbabb53c501b9f9843794f6ff8c343a8fa37b23599"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""2-keto-4-pentenoate hydratase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77608.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-046_b273e04946e2	UniProtKB:P51020	pathwaymech:enables	RHEA:22625	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:16782065|PMID:9758851|UniProtKB:P51020	MhpE supplies the class-I aldol cleavage. Partially purified K-12 enzyme acted on one substrate enantiomer, presumed 4S from the preceding hydration; the current S-specific equation is a curated assignment. MhpF supports folding, so this edge does not assert independent monomer sufficiency.	"[{""reference_id"": ""UniProtKB:P51020"", ""source_assertion"": ""The entry assigns the S-specific RHEA:22624 reaction by HAMAP and records interaction with MhpF."", ""source_locator"": ""comments[1]/reaction; comments[4]""}, {""reference_id"": ""PMID:9758851"", ""source_assertion"": ""Partially purified W3110 aldolase cleaved one enantiomer; the conclusion calls it presumably 4S. Class-I evidence and lack of divalent-metal dependence distinguish it from a Pseudomonas enzyme."", ""source_locator"": ""Full article, purification and characterization paragraphs; concluding paragraph""}, {""quote"": ""showed no observable dependence on divalent metal ions"", ""reference_id"": ""PMID:9758851"", ""source_locator"": ""Full article, paragraph on purified HKP aldolase properties""}, {""reference_id"": ""PMID:16782065"", ""source_assertion"": ""The abstract reports MhpE association with MhpF and an indispensable role of MhpF in MhpE folding; it does not supply a fixed complex stoichiometry."", ""source_locator"": ""Europe PMC resultList/result[0]/abstractText""}]"	"[{""id"": ""PMID:16782065"", ""source_sha256"": ""4d3839621118a2a61f3477c548ca07fad0475fa003557608b8b438491a7dc475"", ""source_version"": ""Europe PMC indexed primary abstract and metadata only; retrieved 2026-10-11; digest covers the complete JSON response"", ""title"": ""Coupled expression of MhpE aldolase and MhpF dehydrogenase in Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16782065%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""PMID:9758851"", ""source_sha256"": ""3be984ba075dda83caf70b3ad4624872123134d6ac046a765d77c477ea3536ea"", ""source_version"": ""Original primary full article HTML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""Substrate selectivity and biochemical properties of 4-hydroxy-2-keto-pentanoic acid aldolase from Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC106610/""}, {""id"": ""UniProtKB:P51020"", ""source_sha256"": ""49339e5bb17013a44f9ef7bd3596aa36b7d3550914084ac440dac5e9ee457983"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""4-hydroxy-2-oxovalerate aldolase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P51020.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-047_3f7a39d40973	UniProtKB:P77580	pathwaymech:catalyzes	RHEA:23289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:16782065|PMID:23237860|UniProtKB:P77580	MhpF oxidizes acetaldehyde to acetyl-CoA using NAD and CoA, completing the native terminal module. Purified MhpF can be active as a monomer and in other oligomeric states; no single invariant MhpEF assembly is asserted.	"[{""reference_id"": ""UniProtKB:P77580"", ""source_assertion"": ""The reviewed entry assigns RHEA:23288 and describes acetaldehyde conversion and MhpE folding support."", ""source_locator"": ""comments[0]; comments[1]/reaction; comments[3]""}, {""reference_id"": ""PMID:23237860"", ""source_assertion"": ""E. coli MhpF is active as a monomer; measured catalytic properties do not depend on oligomeric state. CoA binding enhances the deacylation reaction."", ""source_locator"": ""Europe PMC resultList/result[0]/abstractText""}, {""reference_id"": ""PMID:16782065"", ""source_assertion"": ""The abstract identifies MhpE and MhpF as the last two enzymes of the E. coli MHP catabolic pathway and reports their association."", ""source_locator"": ""Europe PMC resultList/result[0]/abstractText""}]"	"[{""id"": ""PMID:16782065"", ""source_sha256"": ""4d3839621118a2a61f3477c548ca07fad0475fa003557608b8b438491a7dc475"", ""source_version"": ""Europe PMC indexed primary abstract and metadata only; retrieved 2026-10-11; digest covers the complete JSON response"", ""title"": ""Coupled expression of MhpE aldolase and MhpF dehydrogenase in Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16782065%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""PMID:23237860"", ""source_sha256"": ""177df45adf6fc4dc648f44c103bd07a30b64fc4febb9ce33c151f92472642910"", ""source_version"": ""Europe PMC indexed primary abstract and metadata only; retrieved 2026-10-11; digest covers the complete JSON response"", ""title"": ""Catalytic properties of a bacterial acylating acetaldehyde dehydrogenase: evidence for several active oligomeric states and coenzyme A activation upon binding."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23237860%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P77580"", ""source_sha256"": ""d617f66c7fea4c5dc7e20ec8efa7483566cef7f2c9fcc1940248ffc35b14bf24"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""Acetaldehyde dehydrogenase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77580.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-048_b3468c0652e8	UniProtKB:P0ABR5	BFO:0000050	MetaCyc:HCAMULTI-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HCAMULTI-CPLX|MetaCyc:PHENYLPRODIOXY-MONOMER	Predicted membership in the putative Hca system; the native component has no numeric coefficient, so neither stoichiometry nor a purified stable assembly is established.	"[{""reference_id"": ""MetaCyc:HCAMULTI-CPLX"", ""source_assertion"": ""The component list names PHENYLPRODIOXY-MONOMER without a numeric coefficient."", ""source_locator"": ""Protein[@frameid=\""HCAMULTI-CPLX\""]/component""}, {""reference_id"": ""MetaCyc:PHENYLPRODIOXY-MONOMER"", ""source_assertion"": ""The native protein cross-reference explicitly identifies UniProt accession P0ABR5."", ""source_locator"": ""Protein[@frameid=\""PHENYLPRODIOXY-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}]"	"[{""id"": ""MetaCyc:HCAMULTI-CPLX"", ""source_sha256"": ""08b325ced327dd86fa1f272b7e375ca84576601105eb5884c3d58736444b9cc1"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAMULTI-CPLX original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAMULTI-CPLX""}, {""id"": ""MetaCyc:PHENYLPRODIOXY-MONOMER"", ""source_sha256"": ""bbbf5db03329cbdd68bff9023d63665a8cffcd5eef2d508e4c362a2d0d3edda3"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc PHENYLPRODIOXY-MONOMER original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PHENYLPRODIOXY-MONOMER""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-049_5051064e07aa	UniProtKB:Q47140	BFO:0000050	MetaCyc:HCAMULTI-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HCAA2-MONOMER|MetaCyc:HCAMULTI-CPLX	Predicted membership in the putative Hca system; the native component has no numeric coefficient, so neither stoichiometry nor a purified stable assembly is established.	"[{""reference_id"": ""MetaCyc:HCAMULTI-CPLX"", ""source_assertion"": ""The component list names HCAA2-MONOMER without a numeric coefficient."", ""source_locator"": ""Protein[@frameid=\""HCAMULTI-CPLX\""]/component""}, {""reference_id"": ""MetaCyc:HCAA2-MONOMER"", ""source_assertion"": ""The native protein cross-reference explicitly identifies UniProt accession Q47140."", ""source_locator"": ""Protein[@frameid=\""HCAA2-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}]"	"[{""id"": ""MetaCyc:HCAA2-MONOMER"", ""source_sha256"": ""470a05425502f013fd33313a24d3f8d31469280f698b7877523fd2721204baa6"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAA2-MONOMER original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAA2-MONOMER""}, {""id"": ""MetaCyc:HCAMULTI-CPLX"", ""source_sha256"": ""08b325ced327dd86fa1f272b7e375ca84576601105eb5884c3d58736444b9cc1"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAMULTI-CPLX original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAMULTI-CPLX""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-050_a9c8a4896b56	UniProtKB:P0ABW0	BFO:0000050	MetaCyc:HCAMULTI-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HCAC-MONOMER|MetaCyc:HCAMULTI-CPLX	Predicted membership in the putative Hca system; the native component has no numeric coefficient, so neither stoichiometry nor a purified stable assembly is established.	"[{""reference_id"": ""MetaCyc:HCAMULTI-CPLX"", ""source_assertion"": ""The component list names HCAC-MONOMER without a numeric coefficient."", ""source_locator"": ""Protein[@frameid=\""HCAMULTI-CPLX\""]/component""}, {""reference_id"": ""MetaCyc:HCAC-MONOMER"", ""source_assertion"": ""The native protein cross-reference explicitly identifies UniProt accession P0ABW0."", ""source_locator"": ""Protein[@frameid=\""HCAC-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}]"	"[{""id"": ""MetaCyc:HCAC-MONOMER"", ""source_sha256"": ""29c31fc10ee9bce09b81e9cb78c2601b762b0648b4bade82ae0dd7a84ad2de61"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAC-MONOMER original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAC-MONOMER""}, {""id"": ""MetaCyc:HCAMULTI-CPLX"", ""source_sha256"": ""08b325ced327dd86fa1f272b7e375ca84576601105eb5884c3d58736444b9cc1"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAMULTI-CPLX original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAMULTI-CPLX""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-051_600b11608db3	UniProtKB:P77650	BFO:0000050	MetaCyc:HCAMULTI-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HCAD-MONOMER|MetaCyc:HCAMULTI-CPLX	Predicted membership in the putative Hca system; the native component has no numeric coefficient, so neither stoichiometry nor a purified stable assembly is established.	"[{""reference_id"": ""MetaCyc:HCAMULTI-CPLX"", ""source_assertion"": ""The component list names HCAD-MONOMER without a numeric coefficient."", ""source_locator"": ""Protein[@frameid=\""HCAMULTI-CPLX\""]/component""}, {""reference_id"": ""MetaCyc:HCAD-MONOMER"", ""source_assertion"": ""The native protein cross-reference explicitly identifies UniProt accession P77650."", ""source_locator"": ""Protein[@frameid=\""HCAD-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}]"	"[{""id"": ""MetaCyc:HCAD-MONOMER"", ""source_sha256"": ""932a1c63a3eb7b7314bdbb3cd6fac7715e9739ade691d61b40cdc81b58d91cfc"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAD-MONOMER original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAD-MONOMER""}, {""id"": ""MetaCyc:HCAMULTI-CPLX"", ""source_sha256"": ""08b325ced327dd86fa1f272b7e375ca84576601105eb5884c3d58736444b9cc1"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAMULTI-CPLX original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAMULTI-CPLX""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-052_f22bae5ce79a	UniProtKB:P0ABR9	BFO:0000050	MetaCyc:DHPDIOXYGEN-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DHPDIOXYGEN-CPLX|MetaCyc:DHPDIOXYGEN-MONOMER|UniProtKB:P0ABR9	The native homomer contains 4 copies of this protein. This agrees with the inspected purified-enzyme assembly evidence.	"[{""reference_id"": ""MetaCyc:DHPDIOXYGEN-CPLX"", ""source_assertion"": ""The component list names DHPDIOXYGEN-MONOMER with coefficient 4."", ""source_locator"": ""Protein[@frameid=\""DHPDIOXYGEN-CPLX\""]/component""}, {""reference_id"": ""MetaCyc:DHPDIOXYGEN-MONOMER"", ""source_assertion"": ""The native protein cross-reference explicitly identifies UniProt accession P0ABR9."", ""source_locator"": ""Protein[@frameid=\""DHPDIOXYGEN-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}, {""reference_id"": ""UniProtKB:P0ABR9"", ""source_assertion"": ""The reviewed subunit annotation is homotetramer, supported by PMID:8399388."", ""source_locator"": ""comments[5]""}]"	"[{""id"": ""MetaCyc:DHPDIOXYGEN-CPLX"", ""source_sha256"": ""da22d52b702153fbea03114f3d52c2f306f866e87ca569c0e3adf98f2d0188e0"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc DHPDIOXYGEN-CPLX original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHPDIOXYGEN-CPLX""}, {""id"": ""MetaCyc:DHPDIOXYGEN-MONOMER"", ""source_sha256"": ""a9fa2f2de9b64d679a1c81656653f2f4cd202604313748774bbac0f05fd68f49"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc DHPDIOXYGEN-MONOMER original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DHPDIOXYGEN-MONOMER""}, {""id"": ""UniProtKB:P0ABR9"", ""source_sha256"": ""45eaf1fdb8bbab73ae322e69cb920426d6a70dfaca01ae4854758b74d7a5091a"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABR9.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-053_16a9652643e9	UniProtKB:P77044	BFO:0000050	MetaCyc:CPLX0-7950	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7950|MetaCyc:MHPCHYDROL-MONOMER|UniProtKB:P77044	The native homomer contains 2 copies of this protein. This agrees with the inspected purified-enzyme assembly evidence.	"[{""reference_id"": ""MetaCyc:CPLX0-7950"", ""source_assertion"": ""The component list names MHPCHYDROL-MONOMER with coefficient 2."", ""source_locator"": ""Protein[@frameid=\""CPLX0-7950\""]/component""}, {""reference_id"": ""MetaCyc:MHPCHYDROL-MONOMER"", ""source_assertion"": ""The native protein cross-reference explicitly identifies UniProt accession P77044."", ""source_locator"": ""Protein[@frameid=\""MHPCHYDROL-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}, {""reference_id"": ""UniProtKB:P77044"", ""source_assertion"": ""The reviewed subunit annotation is homodimer, with primary and HAMAP support."", ""source_locator"": ""comments[5]""}]"	"[{""id"": ""MetaCyc:CPLX0-7950"", ""source_sha256"": ""3d4bd268bc14f0d3d059219f1670b09a333fdd68b938fc1e3085512c9872cdf6"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc CPLX0-7950 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7950""}, {""id"": ""MetaCyc:MHPCHYDROL-MONOMER"", ""source_sha256"": ""466b7bb91557930419f91adb111d785d6f2bd40e632d9924fe7351cca67d0aef"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc MHPCHYDROL-MONOMER original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MHPCHYDROL-MONOMER""}, {""id"": ""UniProtKB:P77044"", ""source_sha256"": ""144f8f0fcf04eafe52ccf3c5f6efec27846b721b3df3c9afaf3799aa2d38b421"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77044.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-054_1c658cd58697	UniProtKB:P77608	BFO:0000050	MetaCyc:CPLX0-7951	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7951|MetaCyc:MHPDHYDROL-MONOMER|PMID:20053352	The native homomer contains 5 copies of this protein. The pentamer is distinguished from the low-pH cage.	"[{""reference_id"": ""MetaCyc:CPLX0-7951"", ""source_assertion"": ""The component list names MHPDHYDROL-MONOMER with coefficient 5."", ""source_locator"": ""Protein[@frameid=\""CPLX0-7951\""]/component""}, {""reference_id"": ""MetaCyc:MHPDHYDROL-MONOMER"", ""source_assertion"": ""The native protein cross-reference explicitly identifies UniProt accession P77608."", ""source_locator"": ""Protein[@frameid=\""MHPDHYDROL-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}, {""reference_id"": ""PMID:20053352"", ""source_assertion"": ""The abstract explicitly identifies the enzyme as pentameric and distinguishes a 60-subunit particle under low-pH crystallization conditions."", ""source_locator"": ""Europe PMC resultList/result[0]/abstractText""}]"	"[{""id"": ""MetaCyc:CPLX0-7951"", ""source_sha256"": ""3b234216eaa5a79eecaef39045f4feeab5ef672bb3c5566c76c65e7aa3c57f53"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc CPLX0-7951 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7951""}, {""id"": ""MetaCyc:MHPDHYDROL-MONOMER"", ""source_sha256"": ""449d19454ba43b924d7eb2d18a86290e668e65ab9b5d18f4685918884979a83e"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc MHPDHYDROL-MONOMER original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MHPDHYDROL-MONOMER""}, {""id"": ""PMID:20053352"", ""source_sha256"": ""586c189c7ac67601c27fd907c9c4bc246cce9ef803f3d8edf11d6ae4190a868a"", ""source_version"": ""Europe PMC indexed primary abstract and metadata only; retrieved 2026-10-11; digest covers the complete JSON response"", ""title"": ""Assembly of a 20-nm protein cage by Escherichia coli 2-hydroxypentadienoic acid hydratase."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20053352%20AND%20SRC:MED&format=json&resultType=core""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-055_3eecd5ec449c	UniProtKB:P0ABR5	pathwaymech:has_cofactor	CHEBI:190135	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ABR5	The HcaE Rieske-cluster assignment is curator inference, not an independently inspected binding measurement.	"[{""reference_id"": ""UniProtKB:P0ABR5"", ""source_assertion"": ""The cofactor annotation specifies one [2Fe-2S] cluster, CHEBI:190135, with ECO:0000305."", ""source_locator"": ""comments[3]""}]"	"[{""id"": ""UniProtKB:P0ABR5"", ""source_sha256"": ""08176c230f3b4a248de3364416a47222d604fa3ee17abcd31de7a61b8bb06b62"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""3-phenylpropionate/cinnamic acid dioxygenase subunit alpha — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABR5.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-056_44c2d228543f	UniProtKB:P0ABR5	pathwaymech:has_cofactor	CHEBI:24875	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ABR5	HcaE has an inferred iron-cation site. The source does not specify an oxidation state, so no Fe(II) substitution is made.	"[{""reference_id"": ""UniProtKB:P0ABR5"", ""source_assertion"": ""The cofactor annotation specifies one Fe cation, CHEBI:24875, with ECO:0000305."", ""source_locator"": ""comments[4]""}]"	"[{""id"": ""UniProtKB:P0ABR5"", ""source_sha256"": ""08176c230f3b4a248de3364416a47222d604fa3ee17abcd31de7a61b8bb06b62"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""3-phenylpropionate/cinnamic acid dioxygenase subunit alpha — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABR5.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-057_d79dfec99466	UniProtKB:P77650	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77650	FAD is retained as the reviewed HcaD cofactor annotation; this comment has no explicit experimental evidence code.	"[{""reference_id"": ""UniProtKB:P77650"", ""source_assertion"": ""The COFACTOR comment names FAD with CHEBI:57692 and no per-assertion evidence code."", ""source_locator"": ""comments[2]""}]"	"[{""id"": ""UniProtKB:P77650"", ""source_sha256"": ""7781933570445ba5da2b33cdf9f8c58a66120b43916bf9d5d5504b236a2d40e4"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77650.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-058_82559c2595e4	UniProtKB:P77397	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:31811039|UniProtKB:P77397	FAD binding is directly supported for purified W3110-derived MhpA. HPLC measured 0.81 mol FAD per mol protein, consistent with approximately equimolar binding under the reported preparation conditions. The current UniProt similarity annotation is retained as a distinct source fact.	"[{""reference_id"": ""UniProtKB:P77397"", ""source_assertion"": ""The COFACTOR comment names FAD, CHEBI:57692, with ECO:0000250."", ""source_locator"": ""comments[3]""}, {""reference_id"": ""PMID:31811039"", ""source_assertion"": ""FAD in purified MhpA coelutes with the authentic standard at 9.61 minutes during HPLC detection at 445 nm. Quantification gives 0.81 mol FAD/mol protein, supporting tightly bound, approximately equimolar FAD."", ""source_locator"": ""HTML section s2.4, paragraph beginning MhpA was proposed to contain an FAD domain; Methods s4.7""}]"	"[{""id"": ""PMID:31811039"", ""source_sha256"": ""f580c01b6ef803b4d27e8832e74117624c7b831e106a121447f3b037c9f0cc38"", ""source_version"": ""Original 2020 primary full article HTML (online December 2019); retrieved 2026-10-11; digest covers complete original response body"", ""title"": ""MhpA Is a Hydroxylase Catalyzing the Initial Reaction of 3-(3-Hydroxyphenyl)Propionate Catabolism in Escherichia coli K-12"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC6997738/""}, {""id"": ""UniProtKB:P77397"", ""source_sha256"": ""b76888f77edc2ab6c759fe2c02e75b96f23b96eec3b4de9885454e99bb4fe376"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77397.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-059_4855d0890c5d	UniProtKB:P0ABR9	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:8399388|UniProtKB:P0ABR9	Purified MhpB requires non-heme Fe(II). Ascorbate was used for reactivation; this does not create an additional bound cofactor assignment.	"[{""reference_id"": ""UniProtKB:P0ABR9"", ""source_assertion"": ""The FUNCTION comment describes iron(II)-dependent oxidative cleavage, with experimental references 8399388 and 8752345."", ""source_locator"": ""comments[0]""}, {""reference_id"": ""PMID:8399388"", ""source_assertion"": ""Fe(II) plus ascorbate reactivated purified apoenzyme; oxidation or complexation of Fe(II) inactivated it."", ""source_locator"": ""Europe PMC resultList/result[0]/abstractText""}]"	"[{""id"": ""PMID:8399388"", ""source_sha256"": ""3e376435e76bcbe0438593806f21ae50a0a260986c602f9d32308f0a8b7d10de"", ""source_version"": ""Europe PMC indexed primary abstract and metadata only; retrieved 2026-10-11; digest covers the complete JSON response"", ""title"": ""Overproduction, purification and properties of 2,3-dihydroxyphenylpropionate 1,2-dioxygenase from Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8399388%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P0ABR9"", ""source_sha256"": ""45eaf1fdb8bbab73ae322e69cb920426d6a70dfaca01ae4854758b74d7a5091a"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABR9.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-060_cb32a0638e79	UniProtKB:P77608	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9492273|UniProtKB:P77608	MhpD requires a divalent metal, with maximal measured activity using Mn(II); this is not a claim that all other metals are inactive.	"[{""reference_id"": ""UniProtKB:P77608"", ""source_assertion"": ""The COFACTOR comment identifies Mn(II), CHEBI:29035, and states that it gives optimum activity among divalent metal ions."", ""source_locator"": ""comments[2]""}, {""reference_id"": ""PMID:9492273"", ""source_assertion"": ""Purified hydratase requires a divalent metal ion and has optimum activity with Mn(II)."", ""source_locator"": ""Europe PMC resultList/result[0]/abstractText""}]"	"[{""id"": ""PMID:9492273"", ""source_sha256"": ""8011ab21cbc52ba40baa5ed1b055928dab5db9e4ddb9ca89d722968bd5259750"", ""source_version"": ""Europe PMC indexed primary abstract and metadata only; retrieved 2026-10-11; digest covers the complete JSON response"", ""title"": ""Purification, characterisation and reaction mechanism of monofunctional 2-hydroxypentadienoic acid hydratase from Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9492273%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P77608"", ""source_sha256"": ""0a121eab4c62110bde416cbbabb53c501b9f9843794f6ff8c343a8fa37b23599"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""2-keto-4-pentenoate hydratase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77608.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-061_d1b6ead54673	UniProtKB:P0ABW0	pathwaymech:has_cofactor	CHEBI:190135	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HCAC-MONOMER|PMID:18286376	The K-12 HcaC Rieske cluster was experimentally characterized in recombinant protein expressed in BL21/Tuner hosts; the expression hosts are not a new pathway taxon claim.	"[{""reference_id"": ""PMID:18286376"", ""source_assertion"": ""Recombinant K-12 HcaC was purified and examined by UV/Vis and EPR; reduced HcaC showed characteristic Rieske [2Fe-2S] signals."", ""source_locator"": ""Europe PMC resultList/result[0]/abstractText""}, {""reference_id"": ""MetaCyc:HCAC-MONOMER"", ""source_assertion"": ""The native HcaC comment cites 18286376 for its Rieske [2Fe-2S] cluster and explicitly cross-references P0ABW0."", ""source_locator"": ""Protein[@frameid=\""HCAC-MONOMER\""]/comment; dblink""}]"	"[{""id"": ""MetaCyc:HCAC-MONOMER"", ""source_sha256"": ""29c31fc10ee9bce09b81e9cb78c2601b762b0648b4bade82ae0dd7a84ad2de61"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAC-MONOMER original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAC-MONOMER""}, {""id"": ""PMID:18286376"", ""source_sha256"": ""7bdb173e9aa75cb385b01c42c4662af4e934ad2f901b86a1fbc6c42b319e05cb"", ""source_version"": ""Europe PMC indexed primary abstract and metadata only; retrieved 2026-10-11; digest covers the complete JSON response"", ""title"": ""Characterization of the recombinant Rieske [2Fe-2S] proteins HcaC and YeaW from E. coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18286376%20AND%20SRC:MED&format=json&resultType=core""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-062_9b8085fc1ebb	UniProtKB:P77044	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77044	The current explicit cytoplasmic GO annotation is retained at protein scope; it does not assign every reaction or subunit a compartment.	"[{""reference_id"": ""UniProtKB:P77044"", ""source_assertion"": ""The GO cross-reference explicitly assigns GO:0005737, cytoplasm, with IDA:EcoliWiki attribution."", ""source_locator"": ""uniProtKBCrossReferences[44]""}]"	"[{""id"": ""UniProtKB:P77044"", ""source_sha256"": ""144f8f0fcf04eafe52ccf3c5f6efec27846b721b3df3c9afaf3799aa2d38b421"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77044.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-063_e7f887638c34	UniProtKB:P77608	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77608	The current explicit cytoplasmic GO annotation is retained at protein scope; it does not assign every reaction or subunit a compartment.	"[{""reference_id"": ""UniProtKB:P77608"", ""source_assertion"": ""The GO cross-reference explicitly assigns GO:0005737, cytoplasm, with IDA:EcoliWiki attribution."", ""source_locator"": ""uniProtKBCrossReferences[43]""}]"	"[{""id"": ""UniProtKB:P77608"", ""source_sha256"": ""0a121eab4c62110bde416cbbabb53c501b9f9843794f6ff8c343a8fa37b23599"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""2-keto-4-pentenoate hydratase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77608.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-064_5cc135d6b390	RHEA:20358	BFO:0000050	MetaCyc:PWY0-1277	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HCAMHPDEG-PWY|MetaCyc:HCAMULTI-RXN|MetaCyc:PWY0-1277|RHEA:20357	This is one of all eight native transformations. Current source-issued Rhea chemistry is selected without adding the opposite direction as a second step.	"[{""reference_id"": ""MetaCyc:HCAMHPDEG-PWY"", ""source_assertion"": ""The native reaction-list explicitly contains HCAMULTI-RXN; the parent PWY0-1277 includes this complete child module."", ""source_locator"": ""Pathway[@frameid=\""HCAMHPDEG-PWY\""]/reaction-list""}, {""reference_id"": ""MetaCyc:PWY0-1277"", ""source_assertion"": ""PWY0-1277 names HCAMHPDEG-PWY in its reaction-list and sub-pathways, defining the full eight-step branched route."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1277\""]/reaction-list; sub-pathways; comment""}, {""reference_id"": ""MetaCyc:HCAMULTI-RXN"", ""source_assertion"": ""The native reaction cross-references RHEA:20357; its physiological direction is preserved separately from the identifier form."", ""source_locator"": ""Reaction[@frameid=\""HCAMULTI-RXN\""]/dblink[dblink-db=\""RHEA\""]; reaction-direction""}, {""reference_id"": ""RHEA:20357"", ""source_assertion"": ""RHEA:20357 identifies the native family member 20357 via rh:accession and the selected catabolic member 20358 via rh:directionalReaction."", ""source_locator"": ""http://rdf.rhea-db.org/20357 rh:accession; rh:directionalReaction http://rdf.rhea-db.org/20358""}]"	"[{""id"": ""MetaCyc:HCAMHPDEG-PWY"", ""source_sha256"": ""6e7c1e4e0b01d08721ad57dc72df161b8ce1db533e0b4c36ec267cc5f34c120f"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAMHPDEG-PWY original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAMHPDEG-PWY""}, {""id"": ""MetaCyc:HCAMULTI-RXN"", ""source_sha256"": ""9d95f1815cb1629d4bc197781656b71807ac6b1289d936254aa70eee11c1bbd6"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAMULTI-RXN original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAMULTI-RXN""}, {""id"": ""MetaCyc:PWY0-1277"", ""source_sha256"": ""91914e055f8ea47bed84a42ade60ef691728e68839014566cb777c887fde8891"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc PWY0-1277 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1277""}, {""id"": ""RHEA:20357"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 20357 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-065_0d09f21ac655	RHEA:25063	BFO:0000050	MetaCyc:PWY0-1277	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HCAMHPDEG-PWY|MetaCyc:PHENPRODIOLDEHYDROG-RXN|MetaCyc:PWY0-1277|RHEA:25062	This is one of all eight native transformations. Current source-issued Rhea chemistry is selected without adding the opposite direction as a second step.	"[{""reference_id"": ""MetaCyc:HCAMHPDEG-PWY"", ""source_assertion"": ""The native reaction-list explicitly contains PHENPRODIOLDEHYDROG-RXN; the parent PWY0-1277 includes this complete child module."", ""source_locator"": ""Pathway[@frameid=\""HCAMHPDEG-PWY\""]/reaction-list""}, {""reference_id"": ""MetaCyc:PWY0-1277"", ""source_assertion"": ""PWY0-1277 names HCAMHPDEG-PWY in its reaction-list and sub-pathways, defining the full eight-step branched route."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1277\""]/reaction-list; sub-pathways; comment""}, {""reference_id"": ""MetaCyc:PHENPRODIOLDEHYDROG-RXN"", ""source_assertion"": ""The native reaction cross-references RHEA:25062; its physiological direction is preserved separately from the identifier form."", ""source_locator"": ""Reaction[@frameid=\""PHENPRODIOLDEHYDROG-RXN\""]/dblink[dblink-db=\""RHEA\""]; reaction-direction""}, {""reference_id"": ""RHEA:25062"", ""source_assertion"": ""RHEA:25062 identifies the native family member 25062 via rh:accession and the selected catabolic member 25063 via rh:directionalReaction."", ""source_locator"": ""http://rdf.rhea-db.org/25062 rh:accession; rh:directionalReaction http://rdf.rhea-db.org/25063""}]"	"[{""id"": ""MetaCyc:HCAMHPDEG-PWY"", ""source_sha256"": ""6e7c1e4e0b01d08721ad57dc72df161b8ce1db533e0b4c36ec267cc5f34c120f"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAMHPDEG-PWY original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAMHPDEG-PWY""}, {""id"": ""MetaCyc:PHENPRODIOLDEHYDROG-RXN"", ""source_sha256"": ""b2ade584b0407a1ee634f7ec1f0f8acc64913439fd196e3ea523bfde327a8d36"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc PHENPRODIOLDEHYDROG-RXN original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PHENPRODIOLDEHYDROG-RXN""}, {""id"": ""MetaCyc:PWY0-1277"", ""source_sha256"": ""91914e055f8ea47bed84a42ade60ef691728e68839014566cb777c887fde8891"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc PWY0-1277 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1277""}, {""id"": ""RHEA:25062"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 25062 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-066_99baf04534fb	RHEA:24786	BFO:0000050	MetaCyc:PWY0-1277	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HCAMHPDEG-PWY|MetaCyc:MHPHYDROXY-RXN|MetaCyc:PWY0-1277|RHEA:24785	This is one of all eight native transformations. Current source-issued Rhea chemistry is selected without adding the opposite direction as a second step.	"[{""reference_id"": ""MetaCyc:HCAMHPDEG-PWY"", ""source_assertion"": ""The native reaction-list explicitly contains MHPHYDROXY-RXN; the parent PWY0-1277 includes this complete child module."", ""source_locator"": ""Pathway[@frameid=\""HCAMHPDEG-PWY\""]/reaction-list""}, {""reference_id"": ""MetaCyc:PWY0-1277"", ""source_assertion"": ""PWY0-1277 names HCAMHPDEG-PWY in its reaction-list and sub-pathways, defining the full eight-step branched route."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1277\""]/reaction-list; sub-pathways; comment""}, {""reference_id"": ""MetaCyc:MHPHYDROXY-RXN"", ""source_assertion"": ""The native reaction cross-references RHEA:24785; its physiological direction is preserved separately from the identifier form."", ""source_locator"": ""Reaction[@frameid=\""MHPHYDROXY-RXN\""]/dblink[dblink-db=\""RHEA\""]; reaction-direction""}, {""reference_id"": ""RHEA:24785"", ""source_assertion"": ""RHEA:24785 identifies the native family member 24785 via rh:accession and the selected catabolic member 24786 via rh:directionalReaction."", ""source_locator"": ""http://rdf.rhea-db.org/24785 rh:accession; rh:directionalReaction http://rdf.rhea-db.org/24786""}]"	"[{""id"": ""MetaCyc:HCAMHPDEG-PWY"", ""source_sha256"": ""6e7c1e4e0b01d08721ad57dc72df161b8ce1db533e0b4c36ec267cc5f34c120f"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAMHPDEG-PWY original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAMHPDEG-PWY""}, {""id"": ""MetaCyc:MHPHYDROXY-RXN"", ""source_sha256"": ""cf7be7e611a87e57934b604f0e13d64c26f4e7a0c09f1facc7613c34ae3efc20"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc MHPHYDROXY-RXN original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MHPHYDROXY-RXN""}, {""id"": ""MetaCyc:PWY0-1277"", ""source_sha256"": ""91914e055f8ea47bed84a42ade60ef691728e68839014566cb777c887fde8891"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc PWY0-1277 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1277""}, {""id"": ""RHEA:24785"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 24785 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-067_ebda1c7e3b98	RHEA:23841	BFO:0000050	MetaCyc:PWY0-1277	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:1.13.11.16-RXN|MetaCyc:HCAMHPDEG-PWY|MetaCyc:PWY0-1277|RHEA:23840	This is one of all eight native transformations. Current source-issued Rhea chemistry is selected without adding the opposite direction as a second step.	"[{""reference_id"": ""MetaCyc:HCAMHPDEG-PWY"", ""source_assertion"": ""The native reaction-list explicitly contains 1.13.11.16-RXN; the parent PWY0-1277 includes this complete child module."", ""source_locator"": ""Pathway[@frameid=\""HCAMHPDEG-PWY\""]/reaction-list""}, {""reference_id"": ""MetaCyc:PWY0-1277"", ""source_assertion"": ""PWY0-1277 names HCAMHPDEG-PWY in its reaction-list and sub-pathways, defining the full eight-step branched route."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1277\""]/reaction-list; sub-pathways; comment""}, {""reference_id"": ""MetaCyc:1.13.11.16-RXN"", ""source_assertion"": ""The native reaction cross-references RHEA:23841; its physiological direction is preserved separately from the identifier form."", ""source_locator"": ""Reaction[@frameid=\""1.13.11.16-RXN\""]/dblink[dblink-db=\""RHEA\""]; reaction-direction""}, {""reference_id"": ""RHEA:23840"", ""source_assertion"": ""RHEA:23840 identifies the native family member 23841 via rh:directionalReaction and the selected catabolic member 23841 via rh:directionalReaction."", ""source_locator"": ""http://rdf.rhea-db.org/23840 rh:directionalReaction; rh:directionalReaction http://rdf.rhea-db.org/23841""}]"	"[{""id"": ""MetaCyc:1.13.11.16-RXN"", ""source_sha256"": ""2919cbc2e8f492911c840450c0d2f37560cb33f5162dc7a57033f69e7178de3c"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc 1.13.11.16-RXN original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:1.13.11.16-RXN""}, {""id"": ""MetaCyc:HCAMHPDEG-PWY"", ""source_sha256"": ""6e7c1e4e0b01d08721ad57dc72df161b8ce1db533e0b4c36ec267cc5f34c120f"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAMHPDEG-PWY original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAMHPDEG-PWY""}, {""id"": ""MetaCyc:PWY0-1277"", ""source_sha256"": ""91914e055f8ea47bed84a42ade60ef691728e68839014566cb777c887fde8891"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc PWY0-1277 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1277""}, {""id"": ""RHEA:23840"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 23840 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-068_ddfb2d092bd9	RHEA:34188	BFO:0000050	MetaCyc:PWY0-1277	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HCAMHPDEG-PWY|MetaCyc:PWY0-1277|RHEA:34187|UniProtKB:P77044	This is one of all eight native transformations. Current source-issued Rhea chemistry is selected without adding the opposite direction as a second step.	"[{""reference_id"": ""MetaCyc:HCAMHPDEG-PWY"", ""source_assertion"": ""The native reaction-list explicitly contains MHPCHYDROL-RXN; the parent PWY0-1277 includes this complete child module."", ""source_locator"": ""Pathway[@frameid=\""HCAMHPDEG-PWY\""]/reaction-list""}, {""reference_id"": ""MetaCyc:PWY0-1277"", ""source_assertion"": ""PWY0-1277 names HCAMHPDEG-PWY in its reaction-list and sub-pathways, defining the full eight-step branched route."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1277\""]/reaction-list; sub-pathways; comment""}, {""reference_id"": ""UniProtKB:P77044"", ""source_assertion"": ""The exact current MhpC dienol hydrolase reaction is cross-referenced as RHEA:34187. The native reaction XML has no Rhea cross-reference."", ""source_locator"": ""comments[1]/reaction/reactionCrossReferences""}, {""reference_id"": ""RHEA:34187"", ""source_assertion"": ""RHEA:34187 links the selected catabolic member 34188 via rh:directionalReaction."", ""source_locator"": ""http://rdf.rhea-db.org/34187 rh:directionalReaction http://rdf.rhea-db.org/34188""}]"	"[{""id"": ""MetaCyc:HCAMHPDEG-PWY"", ""source_sha256"": ""6e7c1e4e0b01d08721ad57dc72df161b8ce1db533e0b4c36ec267cc5f34c120f"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAMHPDEG-PWY original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAMHPDEG-PWY""}, {""id"": ""MetaCyc:PWY0-1277"", ""source_sha256"": ""91914e055f8ea47bed84a42ade60ef691728e68839014566cb777c887fde8891"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc PWY0-1277 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1277""}, {""id"": ""RHEA:34187"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 34187 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P77044"", ""source_sha256"": ""144f8f0fcf04eafe52ccf3c5f6efec27846b721b3df3c9afaf3799aa2d38b421"", ""source_version"": ""UniProt 2026_03, released 2026-09-02; retrieved 2026-10-11; digest covers the complete entry JSON body"", ""title"": ""2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase — reviewed E. coli K-12 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77044.json""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-069_eb2a03830ad1	RHEA:22582	BFO:0000050	MetaCyc:PWY0-1277	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:2-OXOPENT-4-ENOATE-HYDRATASE-RXN|MetaCyc:PWY-5162|MetaCyc:PWY0-1277|RHEA:22580	This is one of all eight native transformations. Current source-issued Rhea chemistry is selected without adding the opposite direction as a second step.	"[{""reference_id"": ""MetaCyc:PWY-5162"", ""source_assertion"": ""The native reaction-list explicitly contains 2-OXOPENT-4-ENOATE-HYDRATASE-RXN; the parent PWY0-1277 includes this complete child module."", ""source_locator"": ""Pathway[@frameid=\""PWY-5162\""]/reaction-list""}, {""reference_id"": ""MetaCyc:PWY0-1277"", ""source_assertion"": ""PWY0-1277 names PWY-5162 in its reaction-list and sub-pathways, defining the full eight-step branched route."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1277\""]/reaction-list; sub-pathways; comment""}, {""reference_id"": ""MetaCyc:2-OXOPENT-4-ENOATE-HYDRATASE-RXN"", ""source_assertion"": ""The native reaction cross-references RHEA:22583; its physiological direction is preserved separately from the identifier form."", ""source_locator"": ""Reaction[@frameid=\""2-OXOPENT-4-ENOATE-HYDRATASE-RXN\""]/dblink[dblink-db=\""RHEA\""]; reaction-direction""}, {""reference_id"": ""RHEA:22580"", ""source_assertion"": ""RHEA:22580 identifies the native family member 22583 via rh:bidirectionalReaction and the selected catabolic member 22582 via rh:directionalReaction."", ""source_locator"": ""http://rdf.rhea-db.org/22580 rh:bidirectionalReaction; rh:directionalReaction http://rdf.rhea-db.org/22582""}]"	"[{""id"": ""MetaCyc:2-OXOPENT-4-ENOATE-HYDRATASE-RXN"", ""source_sha256"": ""5b0e20c54703970270da12ad2e2d3f2c2888caa2de8d909f2db73ffb53c4cd00"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc 2-OXOPENT-4-ENOATE-HYDRATASE-RXN original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:2-OXOPENT-4-ENOATE-HYDRATASE-RXN""}, {""id"": ""MetaCyc:PWY-5162"", ""source_sha256"": ""eeb61c2f286f46c8245e950f834810d0f4d288bfd7556387a0c26aff2f8d6e52"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc PWY-5162 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5162""}, {""id"": ""MetaCyc:PWY0-1277"", ""source_sha256"": ""91914e055f8ea47bed84a42ade60ef691728e68839014566cb777c887fde8891"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc PWY0-1277 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1277""}, {""id"": ""RHEA:22580"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 22580 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-070_f9c314c909ba	RHEA:22625	BFO:0000050	MetaCyc:PWY0-1277	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:MHPELY-RXN|MetaCyc:PWY-5162|MetaCyc:PWY0-1277|RHEA:22624	This is one of all eight native transformations. Current source-issued Rhea chemistry is selected without adding the opposite direction as a second step.	"[{""reference_id"": ""MetaCyc:PWY-5162"", ""source_assertion"": ""The native reaction-list explicitly contains MHPELY-RXN; the parent PWY0-1277 includes this complete child module."", ""source_locator"": ""Pathway[@frameid=\""PWY-5162\""]/reaction-list""}, {""reference_id"": ""MetaCyc:PWY0-1277"", ""source_assertion"": ""PWY0-1277 names PWY-5162 in its reaction-list and sub-pathways, defining the full eight-step branched route."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1277\""]/reaction-list; sub-pathways; comment""}, {""reference_id"": ""MetaCyc:MHPELY-RXN"", ""source_assertion"": ""The native reaction cross-references RHEA:22627; its physiological direction is preserved separately from the identifier form."", ""source_locator"": ""Reaction[@frameid=\""MHPELY-RXN\""]/dblink[dblink-db=\""RHEA\""]; reaction-direction""}, {""reference_id"": ""RHEA:22624"", ""source_assertion"": ""RHEA:22624 identifies the native family member 22627 via rh:bidirectionalReaction and the selected catabolic member 22625 via rh:directionalReaction."", ""source_locator"": ""http://rdf.rhea-db.org/22624 rh:bidirectionalReaction; rh:directionalReaction http://rdf.rhea-db.org/22625""}]"	"[{""id"": ""MetaCyc:MHPELY-RXN"", ""source_sha256"": ""acf8b60cc575b9e4d2794b0556f4277aee25c9605a589b389294151681a00df7"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc MHPELY-RXN original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MHPELY-RXN""}, {""id"": ""MetaCyc:PWY-5162"", ""source_sha256"": ""eeb61c2f286f46c8245e950f834810d0f4d288bfd7556387a0c26aff2f8d6e52"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc PWY-5162 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5162""}, {""id"": ""MetaCyc:PWY0-1277"", ""source_sha256"": ""91914e055f8ea47bed84a42ade60ef691728e68839014566cb777c887fde8891"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc PWY0-1277 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1277""}, {""id"": ""RHEA:22624"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 22624 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-071_c72c62319dbf	RHEA:23289	BFO:0000050	MetaCyc:PWY0-1277	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ACETALD-DEHYDROG-RXN|MetaCyc:PWY-5162|MetaCyc:PWY0-1277|RHEA:23288	This is one of all eight native transformations. Current source-issued Rhea chemistry is selected without adding the opposite direction as a second step.	"[{""reference_id"": ""MetaCyc:PWY-5162"", ""source_assertion"": ""The native reaction-list explicitly contains ACETALD-DEHYDROG-RXN; the parent PWY0-1277 includes this complete child module."", ""source_locator"": ""Pathway[@frameid=\""PWY-5162\""]/reaction-list""}, {""reference_id"": ""MetaCyc:PWY0-1277"", ""source_assertion"": ""PWY0-1277 names PWY-5162 in its reaction-list and sub-pathways, defining the full eight-step branched route."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1277\""]/reaction-list; sub-pathways; comment""}, {""reference_id"": ""MetaCyc:ACETALD-DEHYDROG-RXN"", ""source_assertion"": ""The native reaction cross-references RHEA:23291; its physiological direction is preserved separately from the identifier form."", ""source_locator"": ""Reaction[@frameid=\""ACETALD-DEHYDROG-RXN\""]/dblink[dblink-db=\""RHEA\""]; reaction-direction""}, {""reference_id"": ""RHEA:23288"", ""source_assertion"": ""RHEA:23288 identifies the native family member 23291 via rh:bidirectionalReaction and the selected catabolic member 23289 via rh:directionalReaction."", ""source_locator"": ""http://rdf.rhea-db.org/23288 rh:bidirectionalReaction; rh:directionalReaction http://rdf.rhea-db.org/23289""}]"	"[{""id"": ""MetaCyc:ACETALD-DEHYDROG-RXN"", ""source_sha256"": ""d0a5faf5aad70b75107ca5517c0d6b6ced3157576de48917eaadb69d26d04f69"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc ACETALD-DEHYDROG-RXN original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ACETALD-DEHYDROG-RXN""}, {""id"": ""MetaCyc:PWY-5162"", ""source_sha256"": ""eeb61c2f286f46c8245e950f834810d0f4d288bfd7556387a0c26aff2f8d6e52"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc PWY-5162 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5162""}, {""id"": ""MetaCyc:PWY0-1277"", ""source_sha256"": ""91914e055f8ea47bed84a42ade60ef691728e68839014566cb777c887fde8891"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc PWY0-1277 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1277""}, {""id"": ""RHEA:23288"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 23288 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-072_5f4195fb4344	RHEA:20358	RO:0002413	RHEA:25063	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HCAMHPDEG-PWY|RHEA:20357|RHEA:25062	The upstream reaction supplies CHEBI:60087 to the downstream reaction. Native pathway order and current chemical-side identities have separate evidence.	"[{""reference_id"": ""MetaCyc:HCAMHPDEG-PWY"", ""source_assertion"": ""The native ordering links HCAMULTI-RXN to PHENPRODIOLDEHYDROG-RXN; the reaction frames, rather than ChEBI identifiers, occur in this ordering source."", ""source_locator"": ""Pathway[@frameid=\""HCAMHPDEG-PWY\""]/reaction-ordering""}, {""reference_id"": ""RHEA:20357"", ""source_assertion"": ""RHEA:20358 products side 20357_R contains coefficient 1 of Participant_20357_compound_6210; its compound accession is CHEBI:60087."", ""source_locator"": ""http://rdf.rhea-db.org/20358 rh:products; http://rdf.rhea-db.org/20357_R rh:contains1 http://rdf.rhea-db.org/Participant_20357_compound_6210; rh:compound http://rdf.rhea-db.org/Compound_6210; rh:accession""}, {""reference_id"": ""RHEA:25062"", ""source_assertion"": ""RHEA:25063 substrates side 25062_L contains coefficient 1 of Participant_25062_compound_6210; its compound accession is CHEBI:60087."", ""source_locator"": ""http://rdf.rhea-db.org/25063 rh:substrates; http://rdf.rhea-db.org/25062_L rh:contains1 http://rdf.rhea-db.org/Participant_25062_compound_6210; rh:compound http://rdf.rhea-db.org/Compound_6210; rh:accession""}]"	"[{""id"": ""MetaCyc:HCAMHPDEG-PWY"", ""source_sha256"": ""6e7c1e4e0b01d08721ad57dc72df161b8ce1db533e0b4c36ec267cc5f34c120f"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAMHPDEG-PWY original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAMHPDEG-PWY""}, {""id"": ""RHEA:20357"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 20357 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:25062"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 25062 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-073_71bc9222d5a7	RHEA:25063	RO:0002413	RHEA:23841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HCAMHPDEG-PWY|RHEA:23840|RHEA:25062	The upstream reaction supplies CHEBI:46951 to the downstream reaction. Native pathway order and current chemical-side identities have separate evidence.	"[{""reference_id"": ""MetaCyc:HCAMHPDEG-PWY"", ""source_assertion"": ""The native ordering links PHENPRODIOLDEHYDROG-RXN to 1.13.11.16-RXN; the reaction frames, rather than ChEBI identifiers, occur in this ordering source."", ""source_locator"": ""Pathway[@frameid=\""HCAMHPDEG-PWY\""]/reaction-ordering""}, {""reference_id"": ""RHEA:25062"", ""source_assertion"": ""RHEA:25063 products side 25062_R contains coefficient 1 of Participant_25062_compound_2958; its compound accession is CHEBI:46951."", ""source_locator"": ""http://rdf.rhea-db.org/25063 rh:products; http://rdf.rhea-db.org/25062_R rh:contains1 http://rdf.rhea-db.org/Participant_25062_compound_2958; rh:compound http://rdf.rhea-db.org/Compound_2958; rh:accession""}, {""reference_id"": ""RHEA:23840"", ""source_assertion"": ""RHEA:23841 substrates side 23840_L contains coefficient 1 of Participant_23840_compound_2958; its compound accession is CHEBI:46951."", ""source_locator"": ""http://rdf.rhea-db.org/23841 rh:substrates; http://rdf.rhea-db.org/23840_L rh:contains1 http://rdf.rhea-db.org/Participant_23840_compound_2958; rh:compound http://rdf.rhea-db.org/Compound_2958; rh:accession""}]"	"[{""id"": ""MetaCyc:HCAMHPDEG-PWY"", ""source_sha256"": ""6e7c1e4e0b01d08721ad57dc72df161b8ce1db533e0b4c36ec267cc5f34c120f"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAMHPDEG-PWY original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAMHPDEG-PWY""}, {""id"": ""RHEA:23840"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 23840 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:25062"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 25062 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-074_0e625b9b554f	RHEA:24786	RO:0002413	RHEA:23841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HCAMHPDEG-PWY|RHEA:23840|RHEA:24785	The upstream reaction supplies CHEBI:46951 to the downstream reaction. Native pathway order and current chemical-side identities have separate evidence.	"[{""reference_id"": ""MetaCyc:HCAMHPDEG-PWY"", ""source_assertion"": ""The native ordering links MHPHYDROXY-RXN to 1.13.11.16-RXN; the reaction frames, rather than ChEBI identifiers, occur in this ordering source."", ""source_locator"": ""Pathway[@frameid=\""HCAMHPDEG-PWY\""]/reaction-ordering""}, {""reference_id"": ""RHEA:24785"", ""source_assertion"": ""RHEA:24786 products side 24785_R contains coefficient 1 of Participant_24785_compound_2958; its compound accession is CHEBI:46951."", ""source_locator"": ""http://rdf.rhea-db.org/24786 rh:products; http://rdf.rhea-db.org/24785_R rh:contains1 http://rdf.rhea-db.org/Participant_24785_compound_2958; rh:compound http://rdf.rhea-db.org/Compound_2958; rh:accession""}, {""reference_id"": ""RHEA:23840"", ""source_assertion"": ""RHEA:23841 substrates side 23840_L contains coefficient 1 of Participant_23840_compound_2958; its compound accession is CHEBI:46951."", ""source_locator"": ""http://rdf.rhea-db.org/23841 rh:substrates; http://rdf.rhea-db.org/23840_L rh:contains1 http://rdf.rhea-db.org/Participant_23840_compound_2958; rh:compound http://rdf.rhea-db.org/Compound_2958; rh:accession""}]"	"[{""id"": ""MetaCyc:HCAMHPDEG-PWY"", ""source_sha256"": ""6e7c1e4e0b01d08721ad57dc72df161b8ce1db533e0b4c36ec267cc5f34c120f"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAMHPDEG-PWY original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAMHPDEG-PWY""}, {""id"": ""RHEA:23840"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 23840 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:24785"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 24785 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-075_32bfb501139d	RHEA:23841	RO:0002413	RHEA:34188	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HCAMHPDEG-PWY|RHEA:23840|RHEA:34187	The upstream reaction supplies CHEBI:66887 to the downstream reaction. Native pathway order and current chemical-side identities have separate evidence.	"[{""reference_id"": ""MetaCyc:HCAMHPDEG-PWY"", ""source_assertion"": ""The native ordering links 1.13.11.16-RXN to MHPCHYDROL-RXN; the reaction frames, rather than ChEBI identifiers, occur in this ordering source."", ""source_locator"": ""Pathway[@frameid=\""HCAMHPDEG-PWY\""]/reaction-ordering""}, {""reference_id"": ""RHEA:23840"", ""source_assertion"": ""RHEA:23841 products side 23840_R contains coefficient 1 of Participant_23840_compound_7449; its compound accession is CHEBI:66887."", ""source_locator"": ""http://rdf.rhea-db.org/23841 rh:products; http://rdf.rhea-db.org/23840_R rh:contains1 http://rdf.rhea-db.org/Participant_23840_compound_7449; rh:compound http://rdf.rhea-db.org/Compound_7449; rh:accession""}, {""reference_id"": ""RHEA:34187"", ""source_assertion"": ""RHEA:34188 substrates side 34187_L contains coefficient 1 of Participant_34187_compound_7449; its compound accession is CHEBI:66887."", ""source_locator"": ""http://rdf.rhea-db.org/34188 rh:substrates; http://rdf.rhea-db.org/34187_L rh:contains1 http://rdf.rhea-db.org/Participant_34187_compound_7449; rh:compound http://rdf.rhea-db.org/Compound_7449; rh:accession""}]"	"[{""id"": ""MetaCyc:HCAMHPDEG-PWY"", ""source_sha256"": ""6e7c1e4e0b01d08721ad57dc72df161b8ce1db533e0b4c36ec267cc5f34c120f"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc HCAMHPDEG-PWY original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HCAMHPDEG-PWY""}, {""id"": ""RHEA:23840"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 23840 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:34187"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 34187 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-076_e100d4a5e644	RHEA:34188	RO:0002413	RHEA:22582	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1277|RHEA:22580|RHEA:34187	The upstream reaction supplies CHEBI:67152 to the downstream reaction. Native pathway order and current chemical-side identities have separate evidence.	"[{""reference_id"": ""MetaCyc:PWY0-1277"", ""source_assertion"": ""The native ordering links MHPCHYDROL-RXN to 2-OXOPENT-4-ENOATE-HYDRATASE-RXN; the reaction frames, rather than ChEBI identifiers, occur in this ordering source."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1277\""]/reaction-ordering""}, {""reference_id"": ""RHEA:34187"", ""source_assertion"": ""RHEA:34188 products side 34187_R contains coefficient 1 of Participant_34187_compound_7450; its compound accession is CHEBI:67152."", ""source_locator"": ""http://rdf.rhea-db.org/34188 rh:products; http://rdf.rhea-db.org/34187_R rh:contains1 http://rdf.rhea-db.org/Participant_34187_compound_7450; rh:compound http://rdf.rhea-db.org/Compound_7450; rh:accession""}, {""reference_id"": ""RHEA:22580"", ""source_assertion"": ""RHEA:22582 substrates side 22580_R contains coefficient 1 of Participant_22580_compound_7450; its compound accession is CHEBI:67152."", ""source_locator"": ""http://rdf.rhea-db.org/22582 rh:substrates; http://rdf.rhea-db.org/22580_R rh:contains1 http://rdf.rhea-db.org/Participant_22580_compound_7450; rh:compound http://rdf.rhea-db.org/Compound_7450; rh:accession""}]"	"[{""id"": ""MetaCyc:PWY0-1277"", ""source_sha256"": ""91914e055f8ea47bed84a42ade60ef691728e68839014566cb777c887fde8891"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc PWY0-1277 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1277""}, {""id"": ""RHEA:22580"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 22580 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:34187"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 34187 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-077_af03861b339f	RHEA:22582	RO:0002413	RHEA:22625	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5162|RHEA:22580|RHEA:22624	The upstream reaction supplies CHEBI:73143 to the downstream reaction. Native pathway order and current chemical-side identities have separate evidence.	"[{""reference_id"": ""MetaCyc:PWY-5162"", ""source_assertion"": ""The native ordering links 2-OXOPENT-4-ENOATE-HYDRATASE-RXN to MHPELY-RXN; the reaction frames, rather than ChEBI identifiers, occur in this ordering source."", ""source_locator"": ""Pathway[@frameid=\""PWY-5162\""]/reaction-ordering""}, {""reference_id"": ""RHEA:22580"", ""source_assertion"": ""RHEA:22582 products side 22580_L contains coefficient 1 of Participant_22580_compound_7920; its compound accession is CHEBI:73143."", ""source_locator"": ""http://rdf.rhea-db.org/22582 rh:products; http://rdf.rhea-db.org/22580_L rh:contains1 http://rdf.rhea-db.org/Participant_22580_compound_7920; rh:compound http://rdf.rhea-db.org/Compound_7920; rh:accession""}, {""reference_id"": ""RHEA:22624"", ""source_assertion"": ""RHEA:22625 substrates side 22624_L contains coefficient 1 of Participant_22624_compound_7920; its compound accession is CHEBI:73143."", ""source_locator"": ""http://rdf.rhea-db.org/22625 rh:substrates; http://rdf.rhea-db.org/22624_L rh:contains1 http://rdf.rhea-db.org/Participant_22624_compound_7920; rh:compound http://rdf.rhea-db.org/Compound_7920; rh:accession""}]"	"[{""id"": ""MetaCyc:PWY-5162"", ""source_sha256"": ""eeb61c2f286f46c8245e950f834810d0f4d288bfd7556387a0c26aff2f8d6e52"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc PWY-5162 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5162""}, {""id"": ""RHEA:22580"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 22580 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:22624"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 22624 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-078_c0ad6c371f2f	RHEA:22625	RO:0002413	RHEA:23289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5162|RHEA:22624|RHEA:23288	The upstream reaction supplies CHEBI:15343 to the downstream reaction. Native pathway order and current chemical-side identities have separate evidence.	"[{""reference_id"": ""MetaCyc:PWY-5162"", ""source_assertion"": ""The native ordering links MHPELY-RXN to ACETALD-DEHYDROG-RXN; the reaction frames, rather than ChEBI identifiers, occur in this ordering source."", ""source_locator"": ""Pathway[@frameid=\""PWY-5162\""]/reaction-ordering""}, {""reference_id"": ""RHEA:22624"", ""source_assertion"": ""RHEA:22625 products side 22624_R contains coefficient 1 of Participant_22624_compound_3952; its compound accession is CHEBI:15343."", ""source_locator"": ""http://rdf.rhea-db.org/22625 rh:products; http://rdf.rhea-db.org/22624_R rh:contains1 http://rdf.rhea-db.org/Participant_22624_compound_3952; rh:compound http://rdf.rhea-db.org/Compound_3952; rh:accession""}, {""reference_id"": ""RHEA:23288"", ""source_assertion"": ""RHEA:23289 substrates side 23288_L contains coefficient 1 of Participant_23288_compound_3952; its compound accession is CHEBI:15343."", ""source_locator"": ""http://rdf.rhea-db.org/23289 rh:substrates; http://rdf.rhea-db.org/23288_L rh:contains1 http://rdf.rhea-db.org/Participant_23288_compound_3952; rh:compound http://rdf.rhea-db.org/Compound_3952; rh:accession""}]"	"[{""id"": ""MetaCyc:PWY-5162"", ""source_sha256"": ""eeb61c2f286f46c8245e950f834810d0f4d288bfd7556387a0c26aff2f8d6e52"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc PWY-5162 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5162""}, {""id"": ""RHEA:22624"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 22624 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:23288"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142; 2026-09-02; digest covers the complete compressed RDF archive"", ""title"": ""Rhea 23288 reaction family and exact directed chemistry"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1277_aromatic-edge-079_b57c74b43d9a	MetaCyc:PWY0-1277	BFO:0000050	NCBITaxon:83333	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1277|PMID:31811039|PMID:6345502|PMID:9098055|PMID:9603882	The route is curated for K-12 lineage evidence. Native MG1655 annotations and experiments in W3110, DH5alpha and complemented K-12 derivatives are distinguished; this does not assert growth by every isolate or by heterologous hosts.	"[{""reference_id"": ""MetaCyc:PWY0-1277"", ""source_assertion"": ""The native pathway identifies E. coli K-12 MG1655 (taxon 511145), a child of K-12 (83333), and describes both branches and terminal acetyl-CoA formation."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1277\""]/species; comment""}, {""reference_id"": ""PMID:6345502"", ""source_assertion"": ""The original K-12 study defines the branched phenylpropionate/hydroxyphenylpropionate route, with succinate, pyruvate and acetaldehyde products."", ""source_locator"": ""Original PDF printed pp. 113-121; Figure 1 on p. 114""}, {""reference_id"": ""PMID:9603882"", ""source_assertion"": ""The study uses K-12-derived strains and distinguishes recombinant Salmonella experiments; whole-cell phenylpropionate conversion and genetics support the Hca branch."", ""source_locator"": ""Materials and Methods, strains; Results, cloning of hca; Figure 1""}, {""reference_id"": ""PMID:9098055"", ""source_assertion"": ""The K-12 mhp cluster map includes MhpA-F, and its growth/complementation experiments distinguish the MC4100 deletion background from competent strains."", ""source_locator"": ""Original PDF Figure 1 p. 2574; Table 2 p. 2577; Results, Identification of mhpR, p. 2578""}, {""reference_id"": ""PMID:31811039"", ""source_assertion"": ""The physiological strain is E. coli K-12 W3110, including an mhpA deletion and complemented derivative. Rosetta(DE3)pLysS is the protein-expression host, not the source strain of the pathway gene."", ""source_locator"": ""HTML Table 3; sections s2.1, s4.2 and s4.4""}]"	"[{""id"": ""MetaCyc:PWY0-1277"", ""source_sha256"": ""91914e055f8ea47bed84a42ade60ef691728e68839014566cb777c887fde8891"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; digest covers the complete original XML response body"", ""title"": ""MetaCyc PWY0-1277 original native XML"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1277""}, {""id"": ""PMID:31811039"", ""source_sha256"": ""f580c01b6ef803b4d27e8832e74117624c7b831e106a121447f3b037c9f0cc38"", ""source_version"": ""Original 2020 primary full article HTML (online December 2019); retrieved 2026-10-11; digest covers complete original response body"", ""title"": ""MhpA Is a Hydroxylase Catalyzing the Initial Reaction of 3-(3-Hydroxyphenyl)Propionate Catabolism in Escherichia coli K-12"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC6997738/""}, {""id"": ""PMID:6345502"", ""source_sha256"": ""fd7db932fc0f777e165944889649d8a4b881372ced33e53db8cc05e4f15473f0"", ""source_version"": ""Original primary full article PDF; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli."", ""url"": ""https://europepmc.org/articles/PMC217659?pdf=render""}, {""id"": ""PMID:9098055"", ""source_sha256"": ""d3d0addea29699950c3fbaaa608787101e2bd48acb450aa1b58093d67574c49b"", ""source_version"": ""Original primary full article PDF; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12."", ""url"": ""https://europepmc.org/articles/PMC179006?pdf=render""}, {""id"": ""PMID:9603882"", ""source_sha256"": ""77422a1136f6f1891af5f8464bf04eb263715f8e39b0eecbd6f59fd912bc0b53"", ""source_version"": ""Original primary full article HTML; retrieved 2026-10-11; digest covers the complete response body"", ""title"": ""Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC107259/""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-001_55481065f807	SGD:S000000107	pathwaymech:enables	gomodel:YeastPathways_PWY3O-6407/6a4c244800000335	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6407/6a4c244800000335 RO:0002333 gomodel:YeastPathways_PWY3O-6407/6a4c244800000339."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/0; endpoint types: /individuals/40/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-002_0ca7f262f2ba	gomodel:RXN3O-9800	BFO:0000050	GO:0008654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9800 BFO:0000050 gomodel:YeastPathways_PWY3O-6407/YeastPathways_PWY3O-6407."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/1; endpoint types: /individuals/14/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-003_9e070de20411	gomodel:RXN-1623	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN-1623 RO:0002234 gomodel:CHEBI_57287_RXN-1623."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/2; endpoint types: /individuals/12/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-004_b53e898582f1	gomodel:RXN3O-5279	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN3O-5279 RO:0002234 gomodel:CHEBI_57287_RXN3O-5279."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/3; endpoint types: /individuals/13/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-005_c8eed90c8f82	gomodel:YeastPathways_PWY3O-6407/6a4c244800000335	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6407/6a4c244800000335 RO:0002234 gomodel:YeastPathways_PWY3O-6407/6a4c244800000338."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/4; endpoint types: /individuals/40/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-006_3eb2b882550a	SGD:S000002210	pathwaymech:enables	gomodel:RXN-1623	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN-1623 RO:0002333 gomodel:YDL052C-MONOMER_RXN-1623_controller."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/5; endpoint types: /individuals/12/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-007_cf2fd892397d	gomodel:YeastPathways_PWY3O-6407/6a4c244800000335	RO:0002233	CHEBI:57642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6407/6a4c244800000335 RO:0002233 gomodel:YeastPathways_PWY3O-6407/6a4c244800000337."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/6; endpoint types: /individuals/40/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-008_f63f1956f657	gomodel:YeastPathways_PWY3O-6407/6a4c244800000335	RO:0002233	CHEBI:33184	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6407/6a4c244800000335 RO:0002233 gomodel:YeastPathways_PWY3O-6407/6a4c244800000336."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/7; endpoint types: /individuals/40/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-009_ebdad0532253	gomodel:RXN3O-9800	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9800 RO:0002233 gomodel:CHEBI_57783_RXN3O-9800."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/8; endpoint types: /individuals/14/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-010_f539c2303e6b	gomodel:YeastPathways_PWY3O-6407/6a4c244800000335	RO:0002234	CHEBI:15835	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6407/6a4c244800000335 RO:0002234 gomodel:CHEBI_15835_RXN3O-5279."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/9; endpoint types: /individuals/40/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-011_077a31d421ad	gomodel:RXN3O-9800	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9800 RO:0002234 gomodel:CHEBI_58349_RXN3O-9800."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/10; endpoint types: /individuals/14/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-012_617ed1f51238	gomodel:RXN3O-9800	RO:0002233	CHEBI:15835	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9800 RO:0002233 gomodel:CHEBI_15835_RXN3O-5279."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/11; endpoint types: /individuals/14/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-014_c3d228f90903	gomodel:YeastPathways_PWY3O-6407/6a4c244800000335	BFO:0000050	GO:0008654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6407/6a4c244800000335 BFO:0000050 gomodel:YeastPathways_PWY3O-6407/YeastPathways_PWY3O-6407."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/13; endpoint types: /individuals/40/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-016_5dde726e8798	gomodel:RXN3O-5279	RO:0002233	CHEBI:33184	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN3O-5279 RO:0002233 gomodel:CHEBI_33184_RXN3O-5279."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/15; endpoint types: /individuals/13/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-017_67af098e3002	gomodel:RXN-1623	RO:0002233	CHEBI:17984	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN-1623 RO:0002233 gomodel:CHEBI_17984_RXN-1623."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/16; endpoint types: /individuals/12/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-019_3c28d5e434ae	gomodel:RXN3O-9800	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9800 RO:0002234 gomodel:CHEBI_15378_RXN3O-9800."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/18; endpoint types: /individuals/14/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-020_4a9891f97573	SGD:S000001775	pathwaymech:enables	gomodel:RXN3O-5279	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN3O-5279 RO:0002333 gomodel:MONOMER3O-4095_RXN3O-5279_controller."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/19; endpoint types: /individuals/13/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-022_784931e1367a	gomodel:RXN-1623	RO:0002233	CHEBI:16975	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN-1623 RO:0002233 gomodel:CHEBI_16975_RXN3O-9800."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/21; endpoint types: /individuals/12/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-023_cf942bf77e98	SGD:S000001386	pathwaymech:enables	gomodel:RXN3O-9800	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9800 RO:0002333 gomodel:YIL124W-MONOMER_RXN3O-9800_controller."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/22; endpoint types: /individuals/14/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-024_621dfd7595b7	gomodel:RXN3O-5279	RO:0002233	CHEBI:57642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN3O-5279 RO:0002233 gomodel:CHEBI_57642_RXN3O-5279."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/23; endpoint types: /individuals/13/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-025_38c0e47770e1	gomodel:RXN-1623	BFO:0000050	GO:0008654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN-1623 BFO:0000050 gomodel:YeastPathways_PWY3O-6407/YeastPathways_PWY3O-6407."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/24; endpoint types: /individuals/12/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-026_c9869a1455cd	gomodel:RXN3O-5279	RO:0002234	CHEBI:15835	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN3O-5279 RO:0002234 gomodel:CHEBI_15835_RXN3O-5279."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/25; endpoint types: /individuals/13/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-027_d98f78e04cc0	gomodel:RXN3O-5279	BFO:0000050	GO:0008654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN3O-5279 BFO:0000050 gomodel:YeastPathways_PWY3O-6407/YeastPathways_PWY3O-6407."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/26; endpoint types: /individuals/13/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-028_7261efdd3a24	gomodel:RXN3O-9800	RO:0002234	CHEBI:16975	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9800 RO:0002234 gomodel:CHEBI_16975_RXN3O-9800."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/27; endpoint types: /individuals/14/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_edge-029_709e3a055bdf	gomodel:RXN-1623	RO:0002234	CHEBI:29089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6407		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_assertion"": ""The model asserts gomodel:RXN-1623 RO:0002234 gomodel:CHEBI_29089_RXN-1623."", ""source_locator"": ""./YeastPathways_PWY3O-6407.json#/facts/28; endpoint types: /individuals/12/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6407"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-6407.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis I (the dihydroxyacetone pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_location-94aa7f03319e_2da4c6eafd58	SGD:S000000107	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32784	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:19525420) Topology: Multi-pass membrane protein. Source qualification: Localizes to both perinuclear and cortical endoplasmic reticulum	"[{""reference_id"": ""UniProtKB:P32784"", ""source_assertion"": ""UniProtKB:P32784 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/995/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32784"", ""source_assertion"": ""UniProtKB:P32784 has the exact SGD cross-reference SGD:S000000107."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/995/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32784"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32784 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_location-f73125fe3ad8_d6e6dbe03d61	SGD:S000002210	RO:0001025	GO:0005811	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33333	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:18154737); ECO:0000269 (PubMed:21820081); ECO:0000269 (PubMed:24868093)	"[{""reference_id"": ""UniProtKB:P33333"", ""source_assertion"": ""UniProtKB:P33333 annotates location Lipid droplet (SL-0154)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1078/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P33333"", ""source_assertion"": ""UniProtKB:P33333 has the exact SGD cross-reference SGD:S000002210."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1078/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P33333"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P33333 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_location-08c8bdd03c17_9aba92fd8ca0	SGD:S000001775	RO:0001025	GO:0005811	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36148	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:22267742); ECO:0000269 (PubMed:31421179); ECO:0000269 (PubMed:9401016) Source qualification: Localizes to both perinuclear and cortical endoplasmic reticulum	"[{""reference_id"": ""UniProtKB:P36148"", ""source_assertion"": ""UniProtKB:P36148 annotates location Lipid droplet (SL-0154)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1237/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P36148"", ""source_assertion"": ""UniProtKB:P36148 has the exact SGD cross-reference SGD:S000001775."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1237/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P36148"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36148 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_location-4afdd2ee8851_49135b97bc3d	SGD:S000001775	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36148	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:19525420); ECO:0000269 (PubMed:31421179) Topology: Multi-pass membrane protein. Source qualification: Localizes to both perinuclear and cortical endoplasmic reticulum	"[{""reference_id"": ""UniProtKB:P36148"", ""source_assertion"": ""UniProtKB:P36148 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1237/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P36148"", ""source_assertion"": ""UniProtKB:P36148 has the exact SGD cross-reference SGD:S000001775."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1237/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P36148"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36148 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_location-52e034770261_b4c7e01c687e	SGD:S000001386	RO:0001025	GO:0005811	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40471	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10515935); ECO:0000269 (PubMed:10617610); ECO:0000269 (PubMed:21820081); ECO:0000269 (PubMed:24868093)	"[{""reference_id"": ""UniProtKB:P40471"", ""source_assertion"": ""UniProtKB:P40471 annotates location Lipid droplet (SL-0154)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1727/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P40471"", ""source_assertion"": ""UniProtKB:P40471 has the exact SGD cross-reference SGD:S000001386."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1727/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40471"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40471 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_location-8082f694cffa_e9a2fa9abec4	SGD:S000001386	RO:0001025	GO:0005741	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40471	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16407407); ECO:0000269 (PubMed:28916712)	"[{""reference_id"": ""UniProtKB:P40471"", ""source_assertion"": ""UniProtKB:P40471 annotates location Mitochondrion outer membrane (SL-0172)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1727/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P40471"", ""source_assertion"": ""UniProtKB:P40471 has the exact SGD cross-reference SGD:S000001386."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1727/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40471"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40471 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_location-db7ccd8f6dbb_8bb42913234c	SGD:S000001386	RO:0001025	GO:0005783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40471	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:28916712)	"[{""reference_id"": ""UniProtKB:P40471"", ""source_assertion"": ""UniProtKB:P40471 annotates location Endoplasmic reticulum (SL-0095)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1727/comments/1/subcellularLocations/2; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P40471"", ""source_assertion"": ""UniProtKB:P40471 has the exact SGD cross-reference SGD:S000001386."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1727/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40471"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40471 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6407_location-cd667bd0c46a_3b68a38ec08f	gomodel:RXN-1623	BFO:0000066	GO:0005811	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33333	Activity compartment supported by an inspected functional annotation. ECO:0000269 (PubMed:17675291); ECO:0000269 (PubMed:17890783); ECO:0000269 (PubMed:20694142); ECO:0000269 (PubMed:9401016). Alternative isoenzymes may function elsewhere.	"[{""reference_id"": ""UniProtKB:P33333"", ""source_assertion"": ""UniProtKB:P33333 describes the corresponding catalytic function in the lipid droplet; this projection applies to the activity enabled by SGD:S000002210."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1078/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P33333"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P33333 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-001_6b679533421c	SGD:S000000107	pathwaymech:enables	gomodel:YeastPathways_PWY3O-6499/6a4c244800001536	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6499/6a4c244800001536 RO:0002333 gomodel:YeastPathways_PWY3O-6499/6a4c244800001540."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/0; endpoint types: /individuals/55/type; /individuals/58/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-002_f3d641a40c69	SGD:S000005420	pathwaymech:enables	gomodel:YeastPathways_PWY3O-6499/6a4c244800001520	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6499/6a4c244800001520 RO:0002333 gomodel:YeastPathways_PWY3O-6499/6a4c244800001526."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/1; endpoint types: /individuals/40/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-003_b6e2be2226eb	gomodel:1.1.1.8-RXN	BFO:0000050	GO:0008654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:1.1.1.8-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-6499/YeastPathways_PWY3O-6499."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/2; endpoint types: /individuals/38/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-004_0de2f20e865a	gomodel:GLYCEROL-3-P-ACYLTRANSFER-RXN	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-3-P-ACYLTRANSFER-RXN RO:0002234 gomodel:CHEBI_57287_GLYCEROL-3-P-ACYLTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/3; endpoint types: /individuals/11/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-005_1cb07fc24fce	gomodel:1.1.1.8-RXN	RO:0002233	CHEBI:57642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:1.1.1.8-RXN RO:0002233 gomodel:CHEBI_57642_1.1.1.8-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/4; endpoint types: /individuals/38/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-006_ad883bc55b2c	gomodel:YeastPathways_PWY3O-6499/6a4c244800001536	RO:0002233	CHEBI:33184	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6499/6a4c244800001536 RO:0002233 gomodel:YeastPathways_PWY3O-6499/6a4c244800001537."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/5; endpoint types: /individuals/55/type; /individuals/56/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-007_623bd378d584	gomodel:RXN-1623	RO:0002234	CHEBI:29089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:RXN-1623 RO:0002234 gomodel:CHEBI_29089_RXN-1623."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/6; endpoint types: /individuals/13/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-008_910e79759ba6	gomodel:YeastPathways_PWY3O-6499/6a4c244800001536	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6499/6a4c244800001536 RO:0002234 gomodel:YeastPathways_PWY3O-6499/6a4c244800001538."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/7; endpoint types: /individuals/55/type; /individuals/57/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-009_8dcc0580846e	gomodel:RXN-1623	BFO:0000050	GO:0008654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:RXN-1623 BFO:0000050 gomodel:YeastPathways_PWY3O-6499/YeastPathways_PWY3O-6499."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/8; endpoint types: /individuals/13/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-010_4e9770710c77	gomodel:YeastPathways_PWY3O-6499/6a4c244800001520	BFO:0000050	GO:0008654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6499/6a4c244800001520 BFO:0000050 gomodel:YeastPathways_PWY3O-6499/YeastPathways_PWY3O-6499."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/9; endpoint types: /individuals/40/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-011_d2f6edb141aa	gomodel:GLYCEROL-3-P-ACYLTRANSFER-RXN	RO:0002234	CHEBI:16975	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-3-P-ACYLTRANSFER-RXN RO:0002234 gomodel:CHEBI_16975_GLYCEROL-3-P-ACYLTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/10; endpoint types: /individuals/11/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-013_7e119f99bb1c	gomodel:RXN-1623	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:RXN-1623 RO:0002234 gomodel:CHEBI_57287_RXN-1623."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/12; endpoint types: /individuals/13/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-014_cd21edc3857b	gomodel:YeastPathways_PWY3O-6499/6a4c244800001520	RO:0002233	CHEBI:57642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6499/6a4c244800001520 RO:0002233 gomodel:YeastPathways_PWY3O-6499/6a4c244800001521."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/13; endpoint types: /individuals/40/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-016_338c113a0f5b	SGD:S000001775	pathwaymech:enables	gomodel:GLYCEROL-3-P-ACYLTRANSFER-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-3-P-ACYLTRANSFER-RXN RO:0002333 gomodel:MONOMER3O-4095_GLYCEROL-3-P-ACYLTRANSFER-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/15; endpoint types: /individuals/11/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-017_019d09f38126	SGD:S000002180	pathwaymech:enables	gomodel:1.1.1.8-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:1.1.1.8-RXN RO:0002333 gomodel:YDL022W-MONOMER_1.1.1.8-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/16; endpoint types: /individuals/38/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-018_b3d3e1ff0b2e	gomodel:GLYCEROL-3-P-ACYLTRANSFER-RXN	RO:0002233	CHEBI:57597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-3-P-ACYLTRANSFER-RXN RO:0002233 gomodel:CHEBI_57597_1.1.1.8-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/17; endpoint types: /individuals/11/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-020_941a94319729	gomodel:RXN-1623	RO:0002233	CHEBI:16975	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:RXN-1623 RO:0002233 gomodel:CHEBI_16975_GLYCEROL-3-P-ACYLTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/19; endpoint types: /individuals/13/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-021_84c016853aa2	gomodel:YeastPathways_PWY3O-6499/6a4c244800001536	BFO:0000050	GO:0008654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6499/6a4c244800001536 BFO:0000050 gomodel:YeastPathways_PWY3O-6499/YeastPathways_PWY3O-6499."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/20; endpoint types: /individuals/55/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-022_38874a8c9eea	gomodel:RXN-1623	RO:0002233	CHEBI:17984	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:RXN-1623 RO:0002233 gomodel:CHEBI_17984_RXN-1623."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/21; endpoint types: /individuals/13/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-023_d1a144871c0d	gomodel:YeastPathways_PWY3O-6499/6a4c244800001536	RO:0002234	CHEBI:16975	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6499/6a4c244800001536 RO:0002234 gomodel:CHEBI_16975_GLYCEROL-3-P-ACYLTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/22; endpoint types: /individuals/55/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-024_502d96d4de2e	gomodel:1.1.1.8-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:1.1.1.8-RXN RO:0002233 gomodel:CHEBI_15378_1.1.1.8-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/23; endpoint types: /individuals/38/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-025_d60adfd5f872	gomodel:YeastPathways_PWY3O-6499/6a4c244800001520	RO:0002234	CHEBI:57597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6499/6a4c244800001520 RO:0002234 gomodel:CHEBI_57597_1.1.1.8-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/24; endpoint types: /individuals/40/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-026_7c4806f35ff7	gomodel:1.1.1.8-RXN	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:1.1.1.8-RXN RO:0002234 gomodel:CHEBI_57540_1.1.1.8-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/25; endpoint types: /individuals/38/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-027_3fd28e41483c	gomodel:GLYCEROL-3-P-ACYLTRANSFER-RXN	RO:0002233	CHEBI:33184	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-3-P-ACYLTRANSFER-RXN RO:0002233 gomodel:CHEBI_33184_GLYCEROL-3-P-ACYLTRANSFER-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/26; endpoint types: /individuals/11/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-028_e2221f48faf7	gomodel:YeastPathways_PWY3O-6499/6a4c244800001520	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6499/6a4c244800001520 RO:0002234 gomodel:YeastPathways_PWY3O-6499/6a4c244800001524."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/27; endpoint types: /individuals/40/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-029_52838d376496	gomodel:1.1.1.8-RXN	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:1.1.1.8-RXN RO:0002233 gomodel:CHEBI_57945_1.1.1.8-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/28; endpoint types: /individuals/38/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-030_d58095ce4636	SGD:S000002210	pathwaymech:enables	gomodel:RXN-1623	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:RXN-1623 RO:0002333 gomodel:YDL052C-MONOMER_RXN-1623_controller."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/29; endpoint types: /individuals/13/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-031_6123b10e73d5	gomodel:YeastPathways_PWY3O-6499/6a4c244800001520	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6499/6a4c244800001520 RO:0002233 gomodel:YeastPathways_PWY3O-6499/6a4c244800001522."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/30; endpoint types: /individuals/40/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-032_cd1add331d63	gomodel:1.1.1.8-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:1.1.1.8-RXN BFO:0000066 gomodel:reaction_1.1.1.8-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/31; endpoint types: /individuals/38/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-033_ca2028b88405	gomodel:YeastPathways_PWY3O-6499/6a4c244800001520	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6499/6a4c244800001520 RO:0002233 gomodel:YeastPathways_PWY3O-6499/6a4c244800001523."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/32; endpoint types: /individuals/40/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-034_e1c34f616501	gomodel:1.1.1.8-RXN	RO:0002234	CHEBI:57597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:1.1.1.8-RXN RO:0002234 gomodel:CHEBI_57597_1.1.1.8-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/33; endpoint types: /individuals/38/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-035_bd28eb9e44c7	gomodel:YeastPathways_PWY3O-6499/6a4c244800001536	RO:0002233	CHEBI:57597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6499/6a4c244800001536 RO:0002233 gomodel:CHEBI_57597_1.1.1.8-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/34; endpoint types: /individuals/55/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-036_eff39b65052a	gomodel:YeastPathways_PWY3O-6499/6a4c244800001520	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-6499/6a4c244800001520 BFO:0000066 gomodel:YeastPathways_PWY3O-6499/6a4c244800001527."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/35; endpoint types: /individuals/40/type; /individuals/46/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_edge-037_a68fc2ac4975	gomodel:GLYCEROL-3-P-ACYLTRANSFER-RXN	BFO:0000050	GO:0008654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-6499		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_assertion"": ""The model asserts gomodel:GLYCEROL-3-P-ACYLTRANSFER-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-6499/YeastPathways_PWY3O-6499."", ""source_locator"": ""./YeastPathways_PWY3O-6499.json#/facts/36; endpoint types: /individuals/11/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-6499"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-13; member ./YeastPathways_PWY3O-6499.json"", ""title"": ""SGD GO-CAM phosphatidate biosynthesis II (the glycerol-3-phosphate pathway) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_location-94aa7f03319e_e118f902f9b1	SGD:S000000107	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32784	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:19525420) Topology: Multi-pass membrane protein. Source qualification: Localizes to both perinuclear and cortical endoplasmic reticulum	"[{""reference_id"": ""UniProtKB:P32784"", ""source_assertion"": ""UniProtKB:P32784 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/995/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32784"", ""source_assertion"": ""UniProtKB:P32784 has the exact SGD cross-reference SGD:S000000107."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/995/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32784"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32784 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_location-4d73746c3f4d_e211f2d1eab9	SGD:S000005420	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41911	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P41911"", ""source_assertion"": ""UniProtKB:P41911 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1828/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P41911"", ""source_assertion"": ""UniProtKB:P41911 has the exact SGD cross-reference SGD:S000005420."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1828/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P41911"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41911 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_location-f948293c7864_50c4241b57f1	SGD:S000005420	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41911	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P41911"", ""source_assertion"": ""UniProtKB:P41911 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1828/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P41911"", ""source_assertion"": ""UniProtKB:P41911 has the exact SGD cross-reference SGD:S000005420."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1828/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P41911"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P41911 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_location-08c8bdd03c17_2dff89d8c7d4	SGD:S000001775	RO:0001025	GO:0005811	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36148	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:22267742); ECO:0000269 (PubMed:31421179); ECO:0000269 (PubMed:9401016) Source qualification: Localizes to both perinuclear and cortical endoplasmic reticulum	"[{""reference_id"": ""UniProtKB:P36148"", ""source_assertion"": ""UniProtKB:P36148 annotates location Lipid droplet (SL-0154)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1237/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P36148"", ""source_assertion"": ""UniProtKB:P36148 has the exact SGD cross-reference SGD:S000001775."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1237/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P36148"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36148 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_location-4afdd2ee8851_f27f67a9b3ca	SGD:S000001775	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36148	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:19525420); ECO:0000269 (PubMed:31421179) Topology: Multi-pass membrane protein. Source qualification: Localizes to both perinuclear and cortical endoplasmic reticulum	"[{""reference_id"": ""UniProtKB:P36148"", ""source_assertion"": ""UniProtKB:P36148 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1237/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P36148"", ""source_assertion"": ""UniProtKB:P36148 has the exact SGD cross-reference SGD:S000001775."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1237/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P36148"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36148 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_location-806bfe23c20b_57c94784f644	SGD:S000002180	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q00055	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:15210723)	"[{""reference_id"": ""UniProtKB:Q00055"", ""source_assertion"": ""UniProtKB:Q00055 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2362/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q00055"", ""source_assertion"": ""UniProtKB:Q00055 has the exact SGD cross-reference SGD:S000002180."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2362/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q00055"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q00055 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_location-39ebc920cefa_d6a2eb91c30c	SGD:S000002180	RO:0001025	GO:0005777	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q00055	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:15210723)	"[{""reference_id"": ""UniProtKB:Q00055"", ""source_assertion"": ""UniProtKB:Q00055 annotates location Peroxisome (SL-0204)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2362/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q00055"", ""source_assertion"": ""UniProtKB:Q00055 has the exact SGD cross-reference SGD:S000002180."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2362/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q00055"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q00055 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_location-f73125fe3ad8_81c2305f5368	SGD:S000002210	RO:0001025	GO:0005811	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33333	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:18154737); ECO:0000269 (PubMed:21820081); ECO:0000269 (PubMed:24868093)	"[{""reference_id"": ""UniProtKB:P33333"", ""source_assertion"": ""UniProtKB:P33333 annotates location Lipid droplet (SL-0154)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1078/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P33333"", ""source_assertion"": ""UniProtKB:P33333 has the exact SGD cross-reference SGD:S000002210."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1078/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P33333"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P33333 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-6499_location-cd667bd0c46a_a70058785ecb	gomodel:RXN-1623	BFO:0000066	GO:0005811	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33333	Activity compartment supported by an inspected functional annotation. ECO:0000269 (PubMed:17675291); ECO:0000269 (PubMed:17890783); ECO:0000269 (PubMed:20694142); ECO:0000269 (PubMed:9401016). Alternative isoenzymes may function elsewhere.	"[{""reference_id"": ""UniProtKB:P33333"", ""source_assertion"": ""UniProtKB:P33333 describes the corresponding catalytic function in the lipid droplet; this projection applies to the activity enabled by SGD:S000002210."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1078/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P33333"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P33333 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-001_e9cfe2cb99d8	gomodel:CHOLINE-KINASE-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:CHOLINE-KINASE-RXN RO:0002233 gomodel:CHEBI_30616_CHOLINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/0; endpoint types: /individuals/13/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-002_6c6cdea882b4	SGD:S000005074	pathwaymech:enables	gomodel:RXN-5781	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:RXN-5781 RO:0002333 gomodel:YNL130C-MONOMER_RXN-5781_controller."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/1; endpoint types: /individuals/14/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-003_6e142d69270c	gomodel:RXN-5781	RO:0002234	CHEBI:60377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:RXN-5781 RO:0002234 gomodel:CHEBI_60377_RXN-5781."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/2; endpoint types: /individuals/14/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-004_c1f6af0f30c6	gomodel:2.7.7.15-RXN	RO:0002234	CHEBI:58779	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:2.7.7.15-RXN RO:0002234 gomodel:CHEBI_58779_2.7.7.15-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/3; endpoint types: /individuals/42/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-005_6a7fa29b8f13	gomodel:RXN-5781	RO:0002234	CHEBI:16110	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:RXN-5781 RO:0002234 gomodel:CHEBI_16110_RXN-5781."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/4; endpoint types: /individuals/14/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-006_a0d3d75329f3	gomodel:CHOLINE-KINASE-RXN	BFO:0000050	GO:0006657	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:CHOLINE-KINASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-450/YeastPathways_PWY3O-450."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/5; endpoint types: /individuals/13/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-007_5168649246eb	gomodel:RXN-5781	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:RXN-5781 RO:0002234 gomodel:CHEBI_15378_RXN-5781."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/6; endpoint types: /individuals/14/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-008_70536e2fe29b	gomodel:2.7.7.15-RXN	RO:0002233	CHEBI:37563	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:2.7.7.15-RXN RO:0002233 gomodel:CHEBI_37563_2.7.7.15-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/7; endpoint types: /individuals/42/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-009_0b90795d5a2c	gomodel:RXN-5781	RO:0002233	CHEBI:17815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:RXN-5781 RO:0002233 gomodel:CHEBI_17815_RXN-5781."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/8; endpoint types: /individuals/14/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-010_60d14006be14	gomodel:2.7.7.15-RXN	BFO:0000050	GO:0006657	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:2.7.7.15-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-450/YeastPathways_PWY3O-450."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/9; endpoint types: /individuals/42/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-012_779e8e2164af	gomodel:2.7.7.15-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:2.7.7.15-RXN RO:0002234 gomodel:CHEBI_29888_2.7.7.15-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/11; endpoint types: /individuals/42/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-013_205af9ba3a19	gomodel:2.7.7.15-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:2.7.7.15-RXN RO:0002233 gomodel:CHEBI_15378_2.7.7.15-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/12; endpoint types: /individuals/42/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-014_eb28d864350f	SGD:S000003434	pathwaymech:enables	gomodel:2.7.7.15-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:2.7.7.15-RXN RO:0002333 gomodel:YGR202C-MONOMER_2.7.7.15-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/13; endpoint types: /individuals/42/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-015_c5c28bc76897	gomodel:2.7.7.15-RXN	RO:0002233	CHEBI:295975	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:2.7.7.15-RXN RO:0002233 gomodel:CHEBI_295975_CHOLINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/14; endpoint types: /individuals/42/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-017_645ecaa69dec	SGD:S000004123	pathwaymech:enables	gomodel:CHOLINE-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:CHOLINE-KINASE-RXN RO:0002333 gomodel:YLR133W-MONOMER_CHOLINE-KINASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/16; endpoint types: /individuals/13/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-018_6991f3892ce0	gomodel:CHOLINE-KINASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:CHOLINE-KINASE-RXN BFO:0000066 gomodel:reaction_CHOLINE-KINASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/17; endpoint types: /individuals/13/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-019_bf975028a9a6	gomodel:RXN-5781	BFO:0000050	GO:0006657	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:RXN-5781 BFO:0000050 gomodel:YeastPathways_PWY3O-450/YeastPathways_PWY3O-450."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/18; endpoint types: /individuals/14/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-020_478c98939bb3	gomodel:RXN-5781	RO:0002233	CHEBI:58779	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:RXN-5781 RO:0002233 gomodel:CHEBI_58779_2.7.7.15-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/19; endpoint types: /individuals/14/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-021_c27eeed6d99c	gomodel:CHOLINE-KINASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:CHOLINE-KINASE-RXN RO:0002234 gomodel:CHEBI_15378_CHOLINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/20; endpoint types: /individuals/13/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-022_ba4b6ef4e681	gomodel:CHOLINE-KINASE-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:CHOLINE-KINASE-RXN RO:0002234 gomodel:CHEBI_456216_CHOLINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/21; endpoint types: /individuals/13/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-023_c2a8226d02d8	gomodel:CHOLINE-KINASE-RXN	RO:0002233	CHEBI:15354	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:CHOLINE-KINASE-RXN RO:0002233 gomodel:CHEBI_15354_CHOLINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/22; endpoint types: /individuals/13/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_edge-024_85c1e7990621	gomodel:CHOLINE-KINASE-RXN	RO:0002234	CHEBI:295975	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-450		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_assertion"": ""The model asserts gomodel:CHOLINE-KINASE-RXN RO:0002234 gomodel:CHEBI_295975_CHOLINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-450.json#/facts/23; endpoint types: /individuals/13/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-450"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-450.json"", ""title"": ""SGD GO-CAM phosphatidylcholine biosynthesis I pathway PWY3O-450"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_location-eb52eff17c5b_b8c480c2a54b	SGD:S000005074	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P17898	Physical protein location from reviewed UniProt. evidence code not specified by source Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P17898"", ""source_assertion"": ""UniProtKB:P17898 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/474/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P17898"", ""source_assertion"": ""UniProtKB:P17898 has the exact SGD cross-reference SGD:S000005074."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/474/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P17898"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P17898 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_location-9c5e6b7c9c11_c870b7bdd2f7	SGD:S000005074	RO:0001025	GO:0005741	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P17898	Physical protein location from reviewed UniProt. evidence code not specified by source Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P17898"", ""source_assertion"": ""UniProtKB:P17898 annotates location Mitochondrion outer membrane (SL-0172)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/474/comments/1/subcellularLocations/2; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P17898"", ""source_assertion"": ""UniProtKB:P17898 has the exact SGD cross-reference SGD:S000005074."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/474/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P17898"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P17898 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_location-89b77122c88e_7dcc6f3bf02c	SGD:S000003434	RO:0001025	GO:0016020	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P13259	Physical protein location from reviewed UniProt. evidence code not specified by source Source qualification: Most of its activity is membrane-associated	"[{""reference_id"": ""UniProtKB:P13259"", ""source_assertion"": ""UniProtKB:P13259 annotates location Membrane (SL-0162)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/364/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P13259"", ""source_assertion"": ""UniProtKB:P13259 has the exact SGD cross-reference SGD:S000003434."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/364/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P13259"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P13259 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_location-1a5839d8187c_3562bc8aad65	SGD:S000004123	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P20485	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P20485"", ""source_assertion"": ""UniProtKB:P20485 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/531/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P20485"", ""source_assertion"": ""UniProtKB:P20485 has the exact SGD cross-reference SGD:S000004123."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/531/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P20485"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P20485 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_cofactor-8569d2c46b5c_e03e2adfbcf1	SGD:S000005074	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P17898	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:1847919)	"[{""reference_id"": ""UniProtKB:P17898"", ""source_assertion"": ""UniProtKB:P17898 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/474/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P17898"", ""source_assertion"": ""UniProtKB:P17898 has the exact SGD cross-reference SGD:S000005074."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/474/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P17898"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P17898 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-450_cofactor-aa6cf1992a88_c8ba1d0a7ab0	SGD:S000004123	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P20485	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:9506987)	"[{""reference_id"": ""UniProtKB:P20485"", ""source_assertion"": ""UniProtKB:P20485 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/531/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P20485"", ""source_assertion"": ""UniProtKB:P20485 has the exact SGD cross-reference SGD:S000004123."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/531/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P20485"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P20485 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-001_81bddf60b6aa	gomodel:YeastPathways_PWY-5669/6a46ef0600000808	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5669/6a46ef0600000808 RO:0002234 gomodel:YeastPathways_PWY-5669/6a46ef0600000810."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/0; endpoint types: /individuals/28/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-002_9b95c8798955	gomodel:PHOSPHASERSYN-RXN	BFO:0000050	GO:0006646	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERSYN-RXN BFO:0000050 gomodel:YeastPathways_PWY-5669/YeastPathways_PWY-5669."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/1; endpoint types: /individuals/9/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-003_f5c2942ba741	gomodel:PHOSPHASERSYN-RXN	RO:0002233	CHEBI:33384	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002233 gomodel:CHEBI_33384_PHOSPHASERSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/2; endpoint types: /individuals/9/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-004_40624f81ad22	gomodel:YeastPathways_PWY-5669/6a46ef0600000808	RO:0002234	CHEBI:16038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5669/6a46ef0600000808 RO:0002234 gomodel:YeastPathways_PWY-5669/6a46ef0600000811."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/3; endpoint types: /individuals/28/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-006_a6f794c47e1a	gomodel:YeastPathways_PWY-5669/6a46ef0600000808	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5669/6a46ef0600000808 RO:0002233 gomodel:YeastPathways_PWY-5669/6a46ef0600000809."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/5; endpoint types: /individuals/28/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-007_849ee30b8097	gomodel:PHOSPHASERSYN-RXN	RO:0002234	CHEBI:11750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002234 gomodel:CHEBI_11750_PHOSPHASERSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/6; endpoint types: /individuals/9/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-008_4365ddaef9c5	gomodel:PHOSPHASERDECARB-RXN	BFO:0000050	GO:0006646	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERDECARB-RXN BFO:0000050 gomodel:YeastPathways_PWY-5669/YeastPathways_PWY-5669."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/7; endpoint types: /individuals/8/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-009_6aa849659714	gomodel:PHOSPHASERDECARB-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERDECARB-RXN RO:0002233 gomodel:CHEBI_15378_PHOSPHASERDECARB-RXN."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/8; endpoint types: /individuals/8/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-010_ea6a64872d3b	gomodel:PHOSPHASERDECARB-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERDECARB-RXN RO:0002234 gomodel:CHEBI_16526_PHOSPHASERDECARB-RXN."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/9; endpoint types: /individuals/8/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-012_6f77b81f291c	gomodel:PHOSPHASERSYN-RXN	RO:0002233	CHEBI:17962	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002233 gomodel:CHEBI_17962_PHOSPHASERSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/11; endpoint types: /individuals/9/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-013_1bd8778cdf65	SGD:S000003402	pathwaymech:enables	gomodel:YeastPathways_PWY-5669/6a46ef0600000808	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5669/6a46ef0600000808 RO:0002333 gomodel:YeastPathways_PWY-5669/6a46ef0600000812."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/12; endpoint types: /individuals/28/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-014_ea1ef043420e	gomodel:PHOSPHASERDECARB-RXN	RO:0002234	CHEBI:16038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERDECARB-RXN RO:0002234 gomodel:CHEBI_16038_PHOSPHASERDECARB-RXN."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/13; endpoint types: /individuals/8/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-016_51a750d56d82	gomodel:PHOSPHASERSYN-RXN	RO:0002234	CHEBI:60377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002234 gomodel:CHEBI_60377_PHOSPHASERSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/15; endpoint types: /individuals/9/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-017_5e9b30c9cc8a	gomodel:YeastPathways_PWY-5669/6a46ef0600000808	BFO:0000050	GO:0006646	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5669/6a46ef0600000808 BFO:0000050 gomodel:YeastPathways_PWY-5669/YeastPathways_PWY-5669."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/16; endpoint types: /individuals/28/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-018_b3acf749777f	SGD:S000000828	pathwaymech:enables	gomodel:PHOSPHASERSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002333 gomodel:YER026C-MONOMER_PHOSPHASERSYN-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/17; endpoint types: /individuals/9/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-019_e439e32c2584	gomodel:PHOSPHASERDECARB-RXN	RO:0002233	CHEBI:11750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERDECARB-RXN RO:0002233 gomodel:CHEBI_11750_PHOSPHASERSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/18; endpoint types: /individuals/8/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-020_17a8942f5ea6	SGD:S000005113	pathwaymech:enables	gomodel:PHOSPHASERDECARB-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERDECARB-RXN RO:0002333 gomodel:YNL169C-MONOMER_PHOSPHASERDECARB-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/19; endpoint types: /individuals/8/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-021_553f5c0bf521	gomodel:PHOSPHASERSYN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002234 gomodel:CHEBI_15378_PHOSPHASERSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/20; endpoint types: /individuals/9/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_edge-022_f5f798c769b3	gomodel:YeastPathways_PWY-5669/6a46ef0600000808	RO:0002233	CHEBI:11750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5669		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5669"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5669/6a46ef0600000808 RO:0002233 gomodel:CHEBI_11750_PHOSPHASERSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5669.json#/facts/21; endpoint types: /individuals/28/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5669"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY-5669.json"", ""title"": ""GO-CAM phosphatidylethanolamine biosynthesis model YeastPathways_PWY-5669"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_location-56e56579324d_b32e03c5977f	SGD:S000003402	RO:0001025	GO:0000139	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53037	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03209); ECO:0000269 (PubMed:7890739) Topology: Peripheral membrane protein. Orientation: Cytoplasmic side.	"[{""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 annotates location Golgi apparatus membrane (SL-0134)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2090/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 has the exact SGD cross-reference SGD:S000003402."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2090/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53037"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53037 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_location-6207f3362a39_797b84234a24	SGD:S000003402	RO:0001025	GO:0010008	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53037	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03209); ECO:0000269 (PubMed:20016005) Topology: Peripheral membrane protein. Orientation: Cytoplasmic side.	"[{""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 annotates location Endosome membrane (SL-0100)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2090/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 has the exact SGD cross-reference SGD:S000003402."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2090/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53037"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53037 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_location-6585f7696d57_f8d430fa9136	SGD:S000000828	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08456	Physical protein location from reviewed UniProt. evidence code not specified by source Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P08456"", ""source_assertion"": ""UniProtKB:P08456 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/205/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P08456"", ""source_assertion"": ""UniProtKB:P08456 has the exact SGD cross-reference SGD:S000000828."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/205/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P08456"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P08456 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_location-558857e0f0ad_076eff80c6fa	SGD:S000000828	RO:0001025	GO:0005741	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08456	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:3005242) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P08456"", ""source_assertion"": ""UniProtKB:P08456 annotates location Mitochondrion outer membrane (SL-0172)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/205/comments/1/subcellularLocations/2; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P08456"", ""source_assertion"": ""UniProtKB:P08456 has the exact SGD cross-reference SGD:S000000828."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/205/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P08456"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P08456 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_location-0e11315efbd5_05c63f38d999	SGD:S000005113	RO:0001025	GO:0005743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39006	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03208); ECO:0000269 (PubMed:14576278); ECO:0000269 (PubMed:22984266); ECO:0000269 (PubMed:23124206); ECO:0000269 (PubMed:29290583); ECO:0000269 (PubMed:3005242); ECO:0000269 (PubMed:33718843); ECO:0000305 (PubMed:34818062); molecular form: Phosphatidylserine decarboxylase 1 beta chain. Topology: Single-pass membrane protein. Orientation: Intermembrane side.	"[{""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 annotates location Mitochondrion inner membrane (SL-0168); molecular form: Phosphatidylserine decarboxylase 1 beta chain."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 has the exact SGD cross-reference SGD:S000005113."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 annotates location Mitochondrion inner membrane (SL-0168); molecular form: Phosphatidylserine decarboxylase 1 alpha chain."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/comments/2/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P39006"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39006 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_location-03ed1a7e29e9_9a6ce3a1a7fb	SGD:S000005113	RO:0001025	GO:0005811	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39006	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:34818062) Source qualification: Localizes to sites of lipid droplet formation on the endoplasmic reticulum membrane	"[{""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 annotates location Lipid droplet (SL-0154)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/comments/3/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 has the exact SGD cross-reference SGD:S000005113."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P39006"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39006 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_location-31e0ba4b0e8a_f112a227f044	SGD:S000005113	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39006	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:29290583); ECO:0000269 (PubMed:34818062) Source qualification: Localizes to sites of lipid droplet formation on the endoplasmic reticulum membrane	"[{""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/comments/3/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 has the exact SGD cross-reference SGD:S000005113."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P39006"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39006 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_location-8b23f76d01f7_4e5185e3da76	gomodel:PHOSPHASERDECARB-RXN	BFO:0000066	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39006	Activity compartment supported by an inspected functional annotation. ECO:0000255 (HAMAP-Rule:MF_03208); ECO:0000269 (PubMed:11294902); ECO:0000269 (PubMed:17976194); ECO:0000269 (PubMed:23045528); ECO:0000269 (PubMed:23124206); ECO:0000269 (PubMed:25829489); ECO:0000269 (PubMed:29290583); ECO:0000269 (PubMed:30926815); ECO:0000269 (PubMed:34818062); ECO:0000269 (PubMed:8227017); ECO:0000269 (PubMed:8407984); ECO:0000269 (PubMed:8530379). Alternative isoenzymes may function elsewhere.	"[{""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 describes the corresponding catalytic function in the mitochondrion; this projection applies to the activity enabled by SGD:S000005113."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P39006"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39006 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_location-c431bce40b2d_d6d4fcf8a954	gomodel:YeastPathways_PWY-5669/6a46ef0600000808	BFO:0000066	GO:0000139	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53037	Activity compartment supported by an inspected functional annotation. ECO:0000255 (HAMAP-Rule:MF_03209); ECO:0000269 (PubMed:11294902); ECO:0000269 (PubMed:20016005); ECO:0000269 (PubMed:24366873); ECO:0000269 (PubMed:7890739); ECO:0000269 (PubMed:7890740). Alternative isoenzymes may function elsewhere.	"[{""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 describes the corresponding catalytic function in the Golgi membrane; this projection applies to the activity enabled by SGD:S000003402."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2090/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53037"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53037 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_location-86fd5bd6cd03_dee0824fc330	gomodel:YeastPathways_PWY-5669/6a46ef0600000808	BFO:0000066	GO:0010008	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53037	Activity compartment supported by an inspected functional annotation. ECO:0000255 (HAMAP-Rule:MF_03209); ECO:0000269 (PubMed:11294902); ECO:0000269 (PubMed:20016005); ECO:0000269 (PubMed:24366873); ECO:0000269 (PubMed:7890739); ECO:0000269 (PubMed:7890740). Alternative isoenzymes may function elsewhere.	"[{""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 describes the corresponding catalytic function in the endosome membrane; this projection applies to the activity enabled by SGD:S000003402."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2090/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53037"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53037 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_cofactor-05e8264b38ea_086ffd2093ff	SGD:S000003402	pathwaymech:has_cofactor	CHEBI:45360	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:45360|UniProtKB:P53037	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The cofactor note explicitly describes a covalently bound pyruvoyl group; use the exact group class rather than free pyruvate. UniProt evidence: ECO:0000250 (UniProtKB:P0A8K1); ECO:0000255 (HAMAP-Rule:MF_03209) Binds 1 pyruvoyl group covalently per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P0A8K1); ECO:0000255 (HAMAP-Rule:MF_03209)	"[{""reference_id"": ""CHEBI:45360"", ""source_assertion"": ""ChEBI labels CHEBI:45360 as pyruvoyl group."", ""source_locator"": ""chebi.obo [Term] id: CHEBI:45360; name: pyruvoyl group""}, {""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 cross-references CHEBI:15361, but its note specifies a covalently bound pyruvoyl group; that group is projected to CHEBI:45360."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2090/comments/0/cofactors/0; /results/2090/comments/0/note""}, {""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 has the exact SGD cross-reference SGD:S000003402."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2090/uniProtKBCrossReferences/0""}]"	"[{""id"": ""CHEBI:45360"", ""source_sha256"": ""6cd3c7f18d8b22c577e110e00008fb288d8f5b34424bbe5011858747062f9dd9"", ""source_version"": ""ChEBI release 255"", ""title"": ""ChEBI CHEBI:45360: pyruvoyl group"", ""url"": ""https://ftp.ebi.ac.uk/pub/databases/chebi/ontology/chebi.obo""}, {""id"": ""UniProtKB:P53037"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53037 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_cofactor-789dceaf9d43_36436792fa2c	SGD:S000003402	pathwaymech:has_cofactor	CHEBI:29108	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53037	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The cofactor note explicitly describes a covalently bound pyruvoyl group; use the exact group class rather than free pyruvate. UniProt evidence: ECO:0000255 (PROSITE-ProRule:PRU00041)	"[{""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 annotates CHEBI:29108 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2090/comments/1/cofactors/0""}, {""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 has the exact SGD cross-reference SGD:S000003402."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2090/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53037"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53037 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_cofactor-2a3454b9a114_b5df28ddb9a0	SGD:S000000828	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08456	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:6088519); ECO:0000269 (PubMed:6274497) Divalent metal cations; Mn(2+) or Mg(2+). UniProt note evidence: ECO:0000269 (PubMed:6088519)	"[{""reference_id"": ""UniProtKB:P08456"", ""source_assertion"": ""UniProtKB:P08456 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/205/comments/0/cofactors/0; /results/205/comments/0/note""}, {""reference_id"": ""UniProtKB:P08456"", ""source_assertion"": ""UniProtKB:P08456 has the exact SGD cross-reference SGD:S000000828."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/205/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P08456"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P08456 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_cofactor-827c72dec25c_fc44f66ffc52	SGD:S000000828	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08456	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:6088519) Divalent metal cations; Mn(2+) or Mg(2+). UniProt note evidence: ECO:0000269 (PubMed:6088519)	"[{""reference_id"": ""UniProtKB:P08456"", ""source_assertion"": ""UniProtKB:P08456 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/205/comments/0/cofactors/1; /results/205/comments/0/note""}, {""reference_id"": ""UniProtKB:P08456"", ""source_assertion"": ""UniProtKB:P08456 has the exact SGD cross-reference SGD:S000000828."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/205/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P08456"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P08456 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5669_cofactor-4f48b265fa2b_14f80ab07bad	SGD:S000005113	pathwaymech:has_cofactor	CHEBI:45360	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:45360|UniProtKB:P39006	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The cofactor note explicitly describes a covalently bound pyruvoyl group; use the exact group class rather than free pyruvate. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03208) Binds 1 pyruvoyl group covalently per subunit. UniProt note evidence: ECO:0000255 (HAMAP-Rule:MF_03208)	"[{""reference_id"": ""CHEBI:45360"", ""source_assertion"": ""ChEBI labels CHEBI:45360 as pyruvoyl group."", ""source_locator"": ""chebi.obo [Term] id: CHEBI:45360; name: pyruvoyl group""}, {""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 cross-references CHEBI:15361, but its note specifies a covalently bound pyruvoyl group; that group is projected to CHEBI:45360."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1539/comments/0/cofactors/0; /results/1539/comments/0/note""}, {""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 has the exact SGD cross-reference SGD:S000005113."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1539/uniProtKBCrossReferences/0""}]"	"[{""id"": ""CHEBI:45360"", ""source_sha256"": ""6cd3c7f18d8b22c577e110e00008fb288d8f5b34424bbe5011858747062f9dd9"", ""source_version"": ""ChEBI release 255"", ""title"": ""ChEBI CHEBI:45360: pyruvoyl group"", ""url"": ""https://ftp.ebi.ac.uk/pub/databases/chebi/ontology/chebi.obo""}, {""id"": ""UniProtKB:P39006"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39006 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-001_def7fac20eac	SGD:S000001915	pathwaymech:enables	gomodel:2.7.1.150-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.150-RXN RO:0002333 gomodel:YFR019W-MONOMER_2.7.1.150-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/0; endpoint types: /individuals/102/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-002_5911b20a7638	gomodel:YeastPathways_PWY3O-242/6a4c244800005962	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005962 RO:0002234 gomodel:YeastPathways_PWY3O-242/6a4c244800005965."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/1; endpoint types: /individuals/148/type; /individuals/151/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-003_11060fb33542	gomodel:YeastPathways_PWY3O-242/6a4c244800006112	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006061	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006112 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006061."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/2; endpoint types: /individuals/283/type; /individuals/238/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-004_cbfdf598b163	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN RO:0002234 gomodel:CHEBI_15378_1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/3; endpoint types: /individuals/100/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-005_1ec72e00b490	gomodel:YeastPathways_PWY3O-242/6a4c244800006112	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006079	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006112 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006079."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/4; endpoint types: /individuals/283/type; /individuals/253/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-006_bf64104c4b9b	SGD:S000002616	pathwaymech:enables	gomodel:2.7.1.68-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.68-RXN RO:0002333 gomodel:YDR208W-MONOMER_2.7.1.68-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/5; endpoint types: /individuals/103/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-007_62a7714fd631	gomodel:YeastPathways_PWY3O-242/6a4c244800006024	RO:0002413	gomodel:RXN-10961	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006024 RO:0002413 gomodel:RXN-10961."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/6; endpoint types: /individuals/204/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-008_142ae12c0f45	gomodel:YeastPathways_PWY3O-242/6a4c244800005984	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005984 RO:0002234 gomodel:YeastPathways_PWY3O-242/6a4c244800005987."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/7; endpoint types: /individuals/168/type; /individuals/171/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-009_0001d419eefb	SGD:S000001695	pathwaymech:enables	gomodel:YeastPathways_PWY3O-242/6a4c244800005945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005945 RO:0002333 gomodel:YeastPathways_PWY3O-242/6a4c244800005948."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/8; endpoint types: /individuals/132/type; /individuals/135/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-010_0a7de7ca20a6	gomodel:YeastPathways_PWY3O-242/6a4c244800006043	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006043 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005945."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/9; endpoint types: /individuals/221/type; /individuals/132/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-012_9b2b50ba9973	gomodel:YeastPathways_PWY3O-242/6a4c244800006151	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006079	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006151 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006079."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/11; endpoint types: /individuals/317/type; /individuals/253/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-014_37de165f9ca2	gomodel:YeastPathways_PWY3O-242/6a4c244800005927	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005927 BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/13; endpoint types: /individuals/116/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-015_d4e015c816d7	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	RO:0002413	gomodel:2.7.1.150-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN RO:0002413 gomodel:2.7.1.150-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/14; endpoint types: /individuals/100/type; /individuals/102/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-016_faeddc49eff1	gomodel:RXN3O-364	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN3O-364 BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/15; endpoint types: /individuals/36/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-017_b5a9eff75122	gomodel:YeastPathways_PWY3O-242/6a4c244800006112	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006112 BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/16; endpoint types: /individuals/283/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-018_59d55e8311e5	gomodel:YeastPathways_PWY3O-242/6a4c244800006079	RO:0002233	CHEBI:17283	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006079 RO:0002233 gomodel:CHEBI_17283_RXN-10938."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/17; endpoint types: /individuals/253/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-019_a221df1742ce	gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN	RO:0002413	gomodel:2.7.1.68-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN RO:0002413 gomodel:2.7.1.68-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/18; endpoint types: /individuals/101/type; /individuals/103/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-021_00866d49f8a4	gomodel:YeastPathways_PWY3O-242/6a4c244800006005	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006005 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005945."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/20; endpoint types: /individuals/188/type; /individuals/132/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-022_2157d043ae5b	SGD:S000005269	pathwaymech:enables	gomodel:RXN-10938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10938 RO:0002333 gomodel:MONOMER3O-86_RXN-10938_controller."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/21; endpoint types: /individuals/34/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-023_c70497ad462f	gomodel:YeastPathways_PWY3O-242/6a4c244800006043	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006043 BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/22; endpoint types: /individuals/221/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-024_72573e875bca	gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN	RO:0002233	CHEBI:57880	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN RO:0002233 gomodel:CHEBI_57880_RXN-10961."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/23; endpoint types: /individuals/101/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-025_4adf4b45a78f	gomodel:YeastPathways_PWY3O-242/6a4c244800005962	RO:0002234	CHEBI:17526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005962 RO:0002234 gomodel:CHEBI_17526_1-PHOSPHATIDYLINOSITOL-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/24; endpoint types: /individuals/148/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-027_ead96603f5c9	gomodel:2.7.1.150-RXN	RO:0002234	CHEBI:16851	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.150-RXN RO:0002234 gomodel:CHEBI_16851_2.7.1.150-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/26; endpoint types: /individuals/102/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-028_4316fea17c23	gomodel:YeastPathways_PWY3O-242/6a4c244800006096	RO:0002233	CHEBI:17283	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006096 RO:0002233 gomodel:CHEBI_17283_RXN-10938."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/27; endpoint types: /individuals/268/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-029_1e1a734ab3ea	gomodel:YeastPathways_PWY3O-242/6a4c244800006151	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006151 BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/28; endpoint types: /individuals/317/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-030_d09e3dfe17a1	gomodel:YeastPathways_PWY3O-242/6a4c244800006061	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006061 RO:0002234 gomodel:YeastPathways_PWY3O-242/6a4c244800006063."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/29; endpoint types: /individuals/238/type; /individuals/240/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-031_a5567025157a	gomodel:YeastPathways_PWY3O-242/6a4c244800006151	RO:0002233	CHEBI:16851	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006151 RO:0002233 gomodel:CHEBI_16851_2.7.1.150-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/30; endpoint types: /individuals/317/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-033_41cc792f2f2b	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006079	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006079."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/32; endpoint types: /individuals/100/type; /individuals/253/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-034_e8da75ced19e	gomodel:YeastPathways_PWY3O-242/6a4c244800006112	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006096	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006112 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006096."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/33; endpoint types: /individuals/283/type; /individuals/268/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-037_f796ec428b7a	gomodel:YeastPathways_PWY3O-242/6a4c244800006112	RO:0002233	CHEBI:16851	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006112 RO:0002233 gomodel:CHEBI_16851_2.7.1.150-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/36; endpoint types: /individuals/283/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-039_ae234d0da570	gomodel:YeastPathways_PWY3O-242/6a4c244800006151	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006061	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006151 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006061."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/38; endpoint types: /individuals/317/type; /individuals/238/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-040_4d28645dd454	gomodel:YeastPathways_PWY3O-242/6a4c244800006061	RO:0002234	CHEBI:57880	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006061 RO:0002234 gomodel:CHEBI_57880_RXN3O-364."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/39; endpoint types: /individuals/238/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-041_5416d2c440e1	gomodel:YeastPathways_PWY3O-242/6a4c244800006079	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006079 RO:0002234 gomodel:YeastPathways_PWY3O-242/6a4c244800006081."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/40; endpoint types: /individuals/253/type; /individuals/255/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-042_f81b8f57cc39	gomodel:YeastPathways_PWY3O-242/6a4c244800006096	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006096 RO:0002234 gomodel:YeastPathways_PWY3O-242/6a4c244800006098."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/41; endpoint types: /individuals/268/type; /individuals/270/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-043_2352f3023835	SGD:S000001695	pathwaymech:enables	gomodel:YeastPathways_PWY3O-242/6a4c244800006151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006151 RO:0002333 gomodel:YeastPathways_PWY3O-242/6a4c244800006155."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/42; endpoint types: /individuals/317/type; /individuals/320/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-044_a720df3cf243	gomodel:YeastPathways_PWY3O-242/6a4c244800005945	RO:0002413	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005945 RO:0002413 gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/43; endpoint types: /individuals/132/type; /individuals/100/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-046_c51059853081	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/45; endpoint types: /individuals/100/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-047_6e97097b91ef	gomodel:YeastPathways_PWY3O-242/6a4c244800005945	RO:0002233	CHEBI:17526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005945 RO:0002233 gomodel:CHEBI_17526_1-PHOSPHATIDYLINOSITOL-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/46; endpoint types: /individuals/132/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-049_8bf0edb234bc	gomodel:YeastPathways_PWY3O-242/6a4c244800006005	RO:0002234	CHEBI:17526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006005 RO:0002234 gomodel:YeastPathways_PWY3O-242/6a4c244800006008."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/48; endpoint types: /individuals/188/type; /individuals/191/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-050_801295fabbda	SGD:S000003871	pathwaymech:enables	gomodel:YeastPathways_PWY3O-242/6a4c244800006096	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006096 RO:0002333 gomodel:YeastPathways_PWY3O-242/6a4c244800006100."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/49; endpoint types: /individuals/268/type; /individuals/271/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-051_6b5f07b04682	gomodel:YeastPathways_PWY3O-242/6a4c244800006096	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006096 BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/50; endpoint types: /individuals/268/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-052_02424b0d73c5	gomodel:2.7.1.150-RXN	RO:0002413	gomodel:RXN-10938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.150-RXN RO:0002413 gomodel:RXN-10938."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/51; endpoint types: /individuals/102/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-053_67c7a098d3f1	gomodel:RXN3O-364	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN3O-364 RO:0002233 gomodel:CHEBI_15377_RXN3O-364."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/52; endpoint types: /individuals/36/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-054_145710f47ee1	gomodel:YeastPathways_PWY3O-242/6a4c244800005927	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005927 RO:0002234 gomodel:YeastPathways_PWY3O-242/6a4c244800005929."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/53; endpoint types: /individuals/116/type; /individuals/118/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-055_0ce290f3245d	gomodel:YeastPathways_PWY3O-242/6a4c244800006132	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006096	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006132 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006096."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/54; endpoint types: /individuals/300/type; /individuals/268/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-056_0dc8c86bb308	SGD:S000005050	pathwaymech:enables	gomodel:RXN3O-364	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN3O-364 RO:0002333 gomodel:MONOMER3O-69_RXN3O-364_controller."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/55; endpoint types: /individuals/36/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-057_fe714221d7f8	gomodel:YeastPathways_PWY3O-242/6a4c244800005927	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005962	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005927 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005962."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/56; endpoint types: /individuals/116/type; /individuals/148/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-058_c18b75949558	gomodel:YeastPathways_PWY3O-242/6a4c244800005962	RO:0002413	gomodel:2.7.1.68-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005962 RO:0002413 gomodel:2.7.1.68-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/57; endpoint types: /individuals/148/type; /individuals/103/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-059_dd203790f166	gomodel:YeastPathways_PWY3O-242/6a4c244800005927	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005984	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005927 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005984."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/58; endpoint types: /individuals/116/type; /individuals/168/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-060_ecba48f2efd7	gomodel:YeastPathways_PWY3O-242/6a4c244800006024	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006024 RO:0002234 gomodel:YeastPathways_PWY3O-242/6a4c244800006026."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/59; endpoint types: /individuals/204/type; /individuals/206/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-061_0a0ae85ba5fe	gomodel:YeastPathways_PWY3O-242/6a4c244800005945	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005945 RO:0002233 gomodel:YeastPathways_PWY3O-242/6a4c244800005946."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/60; endpoint types: /individuals/132/type; /individuals/133/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-062_209a503b0002	gomodel:YeastPathways_PWY3O-242/6a4c244800006043	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006043 RO:0002233 gomodel:YeastPathways_PWY3O-242/6a4c244800006044."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/61; endpoint types: /individuals/221/type; /individuals/222/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-063_23b158a680db	gomodel:RXN-10938	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10938 RO:0002233 gomodel:CHEBI_15377_RXN-10938."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/62; endpoint types: /individuals/34/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-064_4fca21d674e5	gomodel:YeastPathways_PWY3O-242/6a4c244800006151	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006096	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006151 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006096."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/63; endpoint types: /individuals/317/type; /individuals/268/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-065_72b04ffc3df9	gomodel:2.7.1.68-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.68-RXN RO:0002234 gomodel:CHEBI_456216_2.7.1.68-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/64; endpoint types: /individuals/103/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-066_1a00c824c89a	gomodel:YeastPathways_PWY3O-242/6a4c244800005984	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005984 RO:0002233 gomodel:YeastPathways_PWY3O-242/6a4c244800005985."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/65; endpoint types: /individuals/168/type; /individuals/169/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-067_d562320b859c	gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/66; endpoint types: /individuals/101/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-068_5c98dcfb58dd	gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN RO:0002234 gomodel:CHEBI_456216_1-PHOSPHATIDYLINOSITOL-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/67; endpoint types: /individuals/101/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-069_7344b4679621	gomodel:YeastPathways_PWY3O-242/6a4c244800006005	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005927	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006005 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005927."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/68; endpoint types: /individuals/188/type; /individuals/116/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-070_f73ecf964b34	gomodel:RXN3O-364	RO:0002413	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN3O-364 RO:0002413 gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/69; endpoint types: /individuals/36/type; /individuals/100/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-071_545ee1e0f0c3	SGD:S000003636	pathwaymech:enables	gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN RO:0002333 gomodel:MONOMER3O-352_1-PHOSPHATIDYLINOSITOL-KINASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/70; endpoint types: /individuals/101/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-072_cbdbc424b8c9	gomodel:YeastPathways_PWY3O-242/6a4c244800005927	RO:0002413	gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005927 RO:0002413 gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/71; endpoint types: /individuals/116/type; /individuals/101/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-073_0db6bf274eb7	gomodel:YeastPathways_PWY3O-242/6a4c244800006061	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006061 RO:0002233 gomodel:YeastPathways_PWY3O-242/6a4c244800006062."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/72; endpoint types: /individuals/238/type; /individuals/239/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-074_1f02fe4eff3f	gomodel:YeastPathways_PWY3O-242/6a4c244800006043	RO:0002234	CHEBI:17526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006043 RO:0002234 gomodel:YeastPathways_PWY3O-242/6a4c244800006046."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/73; endpoint types: /individuals/221/type; /individuals/224/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-075_b9822d9d7942	gomodel:YeastPathways_PWY3O-242/6a4c244800005984	RO:0002234	CHEBI:17526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005984 RO:0002234 gomodel:CHEBI_17526_1-PHOSPHATIDYLINOSITOL-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/74; endpoint types: /individuals/168/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-076_d2f12225d39f	gomodel:YeastPathways_PWY3O-242/6a4c244800005962	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005962 BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/75; endpoint types: /individuals/148/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-077_22428770936c	gomodel:YeastPathways_PWY3O-242/6a4c244800005927	RO:0002413	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005927 RO:0002413 gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/76; endpoint types: /individuals/116/type; /individuals/100/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-078_7f8f5b6cd50b	gomodel:YeastPathways_PWY3O-242/6a4c244800006132	RO:0002234	CHEBI:17283	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006132 RO:0002234 gomodel:CHEBI_17283_RXN-10938."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/77; endpoint types: /individuals/300/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-079_a6a95f467605	gomodel:YeastPathways_PWY3O-242/6a4c244800006061	RO:0002413	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006061 RO:0002413 gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/78; endpoint types: /individuals/238/type; /individuals/100/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-080_d73f4ff9a904	gomodel:YeastPathways_PWY3O-242/6a4c244800006132	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006061	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006132 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006061."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/79; endpoint types: /individuals/300/type; /individuals/238/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-081_5fe5b7e44895	gomodel:YeastPathways_PWY3O-242/6a4c244800006132	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006132 RO:0002234 gomodel:YeastPathways_PWY3O-242/6a4c244800006134."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/80; endpoint types: /individuals/300/type; /individuals/302/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-082_aa32ac14851b	gomodel:YeastPathways_PWY3O-242/6a4c244800006132	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006079	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006132 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006079."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/81; endpoint types: /individuals/300/type; /individuals/253/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-083_6e17ee3e4def	gomodel:RXN-10961	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005962	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10961 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005962."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/82; endpoint types: /individuals/35/type; /individuals/148/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-084_80b35ca1f1dd	gomodel:YeastPathways_PWY3O-242/6a4c244800005927	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005927 BFO:0000066 gomodel:YeastPathways_PWY3O-242/6a4c244800005933."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/83; endpoint types: /individuals/116/type; /individuals/120/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-085_ec0a3f6d29ab	gomodel:YeastPathways_PWY3O-242/6a4c244800006132	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006132 BFO:0000066 gomodel:YeastPathways_PWY3O-242/6a4c244800006138."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/84; endpoint types: /individuals/300/type; /individuals/304/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-086_8c69cf67d772	gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN	RO:0002413	gomodel:RXN-10961	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN RO:0002413 gomodel:RXN-10961."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/85; endpoint types: /individuals/33/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-087_9c875ea2b8ba	gomodel:YeastPathways_PWY3O-242/6a4c244800005945	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005945 BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/86; endpoint types: /individuals/132/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-088_1d15ce39a14c	gomodel:YeastPathways_PWY3O-242/6a4c244800006061	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006061 BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/87; endpoint types: /individuals/238/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-089_e307efa60ce1	gomodel:YeastPathways_PWY3O-242/6a4c244800005962	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005962 RO:0002234 gomodel:YeastPathways_PWY3O-242/6a4c244800005964."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/88; endpoint types: /individuals/148/type; /individuals/150/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-090_7c5ef8307203	gomodel:YeastPathways_PWY3O-242/6a4c244800006024	RO:0002234	CHEBI:17526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006024 RO:0002234 gomodel:YeastPathways_PWY3O-242/6a4c244800006027."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/89; endpoint types: /individuals/204/type; /individuals/207/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-091_5189f575778c	gomodel:YeastPathways_PWY3O-242/6a4c244800006112	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006112 RO:0002233 gomodel:YeastPathways_PWY3O-242/6a4c244800006113."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/90; endpoint types: /individuals/283/type; /individuals/284/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-092_8aa53dad0ddd	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	RO:0002413	gomodel:RXN3O-364	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN RO:0002413 gomodel:RXN3O-364."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/91; endpoint types: /individuals/100/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-093_eae7729bafeb	gomodel:RXN-10938	RO:0002233	CHEBI:16851	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10938 RO:0002233 gomodel:CHEBI_16851_2.7.1.150-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/92; endpoint types: /individuals/34/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-094_3a3b98c25964	gomodel:YeastPathways_PWY3O-242/6a4c244800006005	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006005 BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/93; endpoint types: /individuals/188/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-095_c029002edc99	gomodel:YeastPathways_PWY3O-242/6a4c244800006079	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006079 BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/94; endpoint types: /individuals/253/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-096_ac1cd80a875c	gomodel:YeastPathways_PWY3O-242/6a4c244800005984	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005984 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005945."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/95; endpoint types: /individuals/168/type; /individuals/132/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-097_3d0f7efacf57	gomodel:YeastPathways_PWY3O-242/6a4c244800005984	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005927	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005984 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005927."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/96; endpoint types: /individuals/168/type; /individuals/116/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-098_df67561c934f	gomodel:YeastPathways_PWY3O-242/6a4c244800006112	RO:0002413	gomodel:RXN3O-364	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006112 RO:0002413 gomodel:RXN3O-364."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/97; endpoint types: /individuals/283/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-099_e94ee29b4349	gomodel:YeastPathways_PWY3O-242/6a4c244800005962	RO:0002233	CHEBI:57880	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005962 RO:0002233 gomodel:CHEBI_57880_RXN-10961."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/98; endpoint types: /individuals/148/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-100_99e30c72f101	SGD:S000004230	pathwaymech:enables	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN RO:0002333 gomodel:YLR240W-MONOMER_1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/99; endpoint types: /individuals/100/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-101_5c8e720527b3	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006096	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006096."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/100; endpoint types: /individuals/100/type; /individuals/268/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-102_ae31a98c9a77	gomodel:YeastPathways_PWY3O-242/6a4c244800006005	RO:0002233	CHEBI:18348	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006005 RO:0002233 gomodel:CHEBI_18348_2.7.1.68-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/101; endpoint types: /individuals/188/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-103_1b9e4e9baf2a	gomodel:RXN-10938	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006079	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10938 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006079."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/102; endpoint types: /individuals/34/type; /individuals/253/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-104_ba97f1d175c7	gomodel:RXN-10961	RO:0002413	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10961 RO:0002413 gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/103; endpoint types: /individuals/35/type; /individuals/100/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-105_3c5f1a059fe1	SGD:S000001264	pathwaymech:enables	gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN RO:0002333 gomodel:MONOMER3O-111_PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/104; endpoint types: /individuals/33/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-106_47761c572678	gomodel:RXN-10938	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10938 RO:0002234 gomodel:CHEBI_43474_RXN-10938."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/105; endpoint types: /individuals/34/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-107_f46d9b5d50ba	gomodel:YeastPathways_PWY3O-242/6a4c244800006151	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006151 RO:0002233 gomodel:YeastPathways_PWY3O-242/6a4c244800006152."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/106; endpoint types: /individuals/317/type; /individuals/318/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-108_726aec44efe8	gomodel:YeastPathways_PWY3O-242/6a4c244800005984	RO:0002413	gomodel:2.7.1.68-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005984 RO:0002413 gomodel:2.7.1.68-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/107; endpoint types: /individuals/168/type; /individuals/103/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-109_d6eadb188aa1	gomodel:YeastPathways_PWY3O-242/6a4c244800006132	RO:0002413	gomodel:RXN3O-364	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006132 RO:0002413 gomodel:RXN3O-364."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/108; endpoint types: /individuals/300/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-110_009ebea9cf28	gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN RO:0002233 gomodel:CHEBI_30616_1-PHOSPHATIDYLINOSITOL-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/109; endpoint types: /individuals/101/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-111_668dda707144	SGD:S000004296	pathwaymech:enables	gomodel:YeastPathways_PWY3O-242/6a4c244800005984	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005984 RO:0002333 gomodel:YeastPathways_PWY3O-242/6a4c244800005989."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/110; endpoint types: /individuals/168/type; /individuals/172/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-112_460ea92b0b8b	gomodel:2.7.1.68-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006005	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.68-RXN RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006005."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/111; endpoint types: /individuals/103/type; /individuals/188/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-113_248d476196cf	gomodel:YeastPathways_PWY3O-242/6a4c244800006024	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006024 BFO:0000066 gomodel:YeastPathways_PWY3O-242/6a4c244800006031."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/112; endpoint types: /individuals/204/type; /individuals/209/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-114_f25896340ad1	SGD:S000005635	pathwaymech:enables	gomodel:YeastPathways_PWY3O-242/6a4c244800006024	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006024 RO:0002333 gomodel:YeastPathways_PWY3O-242/6a4c244800006028."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/113; endpoint types: /individuals/204/type; /individuals/208/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-115_084d552d0ec3	gomodel:RXN-10961	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10961 BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/114; endpoint types: /individuals/35/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-116_80a0ae3799f4	gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN RO:0002234 gomodel:CHEBI_43474_PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/115; endpoint types: /individuals/33/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-117_6b90b4b66819	gomodel:RXN-10938	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006061	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10938 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006061."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/116; endpoint types: /individuals/34/type; /individuals/238/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-118_d20f82e818b2	gomodel:YeastPathways_PWY3O-242/6a4c244800005927	RO:0002233	CHEBI:17526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005927 RO:0002233 gomodel:CHEBI_17526_1-PHOSPHATIDYLINOSITOL-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/117; endpoint types: /individuals/116/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-119_d0756ee2f3c0	gomodel:YeastPathways_PWY3O-242/6a4c244800006079	RO:0002234	CHEBI:57880	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006079 RO:0002234 gomodel:CHEBI_57880_RXN3O-364."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/118; endpoint types: /individuals/253/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-120_c7347718a6cb	gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/119; endpoint types: /individuals/33/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-121_53872f8bce61	gomodel:2.7.1.150-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.150-RXN RO:0002233 gomodel:CHEBI_30616_2.7.1.150-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/120; endpoint types: /individuals/102/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-122_f416f4796cd2	gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN	RO:0002234	CHEBI:17526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN RO:0002234 gomodel:CHEBI_17526_PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/121; endpoint types: /individuals/33/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-123_b01f46fe548b	gomodel:2.7.1.68-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006043	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.68-RXN RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006043."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/122; endpoint types: /individuals/103/type; /individuals/221/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-124_747828307a9d	gomodel:RXN-10938	RO:0002234	CHEBI:17283	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10938 RO:0002234 gomodel:CHEBI_17283_RXN-10938."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/123; endpoint types: /individuals/34/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-125_5b3317d5c665	gomodel:YeastPathways_PWY3O-242/6a4c244800006132	RO:0002233	CHEBI:16851	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006132 RO:0002233 gomodel:CHEBI_16851_2.7.1.150-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/124; endpoint types: /individuals/300/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-126_3329481317fd	gomodel:RXN-10938	RO:0002413	gomodel:RXN3O-364	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10938 RO:0002413 gomodel:RXN3O-364."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/125; endpoint types: /individuals/34/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-127_31b835958744	gomodel:2.7.1.150-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.150-RXN RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006151."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/126; endpoint types: /individuals/102/type; /individuals/317/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-128_b04bb15b735d	gomodel:YeastPathways_PWY3O-242/6a4c244800006005	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006005 RO:0002233 gomodel:YeastPathways_PWY3O-242/6a4c244800006006."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/127; endpoint types: /individuals/188/type; /individuals/189/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-129_5d439956f44e	gomodel:RXN-10938	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006096	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10938 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006096."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/128; endpoint types: /individuals/34/type; /individuals/268/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-130_c76aac0f2ac4	gomodel:YeastPathways_PWY3O-242/6a4c244800006024	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005927	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006024 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005927."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/129; endpoint types: /individuals/204/type; /individuals/116/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-131_644ee6c5ca4d	gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN	RO:0002234	CHEBI:17526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN RO:0002234 gomodel:CHEBI_17526_1-PHOSPHATIDYLINOSITOL-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/130; endpoint types: /individuals/101/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-132_fd8eb84bd79d	gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005927	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005927."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/131; endpoint types: /individuals/101/type; /individuals/116/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-133_286e5cf63a93	gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN	RO:0002413	gomodel:RXN-10961	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN RO:0002413 gomodel:RXN-10961."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/132; endpoint types: /individuals/101/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-134_709bc0378dd8	gomodel:2.7.1.150-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006132	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.150-RXN RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006132."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/133; endpoint types: /individuals/102/type; /individuals/300/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-135_2ce6905be436	gomodel:YeastPathways_PWY3O-242/6a4c244800006151	RO:0002413	gomodel:RXN3O-364	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006151 RO:0002413 gomodel:RXN3O-364."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/134; endpoint types: /individuals/317/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-136_811e16bf0021	SGD:S000005050	pathwaymech:enables	gomodel:RXN-10961	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10961 RO:0002333 gomodel:MONOMER3O-69_RXN-10961_controller."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/135; endpoint types: /individuals/35/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-137_0e58985b5291	gomodel:RXN-10961	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10961 RO:0002233 gomodel:CHEBI_15377_RXN-10961."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/136; endpoint types: /individuals/35/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-139_35ad069a960e	gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005927	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005927."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/138; endpoint types: /individuals/33/type; /individuals/116/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-140_0bf3489a5be9	gomodel:YeastPathways_PWY3O-242/6a4c244800006112	RO:0002234	CHEBI:17283	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006112 RO:0002234 gomodel:CHEBI_17283_RXN-10938."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/139; endpoint types: /individuals/283/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-141_f96774d4a00e	gomodel:YeastPathways_PWY3O-242/6a4c244800005984	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005984 BFO:0000066 gomodel:YeastPathways_PWY3O-242/6a4c244800005990."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/140; endpoint types: /individuals/168/type; /individuals/173/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-142_e38a2c826e6a	gomodel:YeastPathways_PWY3O-242/6a4c244800006151	RO:0002234	CHEBI:17283	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006151 RO:0002234 gomodel:CHEBI_17283_RXN-10938."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/141; endpoint types: /individuals/317/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-143_71439a58f1dd	gomodel:YeastPathways_PWY3O-242/6a4c244800005984	RO:0002233	CHEBI:57880	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005984 RO:0002233 gomodel:CHEBI_57880_RXN-10961."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/142; endpoint types: /individuals/168/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-144_c27fdda819bd	gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN RO:0002234 gomodel:CHEBI_15378_1-PHOSPHATIDYLINOSITOL-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/143; endpoint types: /individuals/101/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-145_7a92604c5fbf	SGD:S000005426	pathwaymech:enables	gomodel:YeastPathways_PWY3O-242/6a4c244800006043	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006043 RO:0002333 gomodel:YeastPathways_PWY3O-242/6a4c244800006047."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/144; endpoint types: /individuals/221/type; /individuals/225/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-146_331c6315e042	gomodel:YeastPathways_PWY3O-242/6a4c244800006024	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006024 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005945."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/145; endpoint types: /individuals/204/type; /individuals/132/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-147_db9f58d1c135	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN RO:0002234 gomodel:CHEBI_456216_1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/146; endpoint types: /individuals/100/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-148_5d8c2cd72f79	gomodel:YeastPathways_PWY3O-242/6a4c244800006079	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006079 RO:0002233 gomodel:YeastPathways_PWY3O-242/6a4c244800006080."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/147; endpoint types: /individuals/253/type; /individuals/254/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-149_63c6aefea2a1	SGD:S000005635	pathwaymech:enables	gomodel:YeastPathways_PWY3O-242/6a4c244800006061	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006061 RO:0002333 gomodel:YeastPathways_PWY3O-242/6a4c244800006065."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/148; endpoint types: /individuals/238/type; /individuals/241/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-150_ae92222f7ca7	gomodel:YeastPathways_PWY3O-242/6a4c244800005962	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005962 RO:0002233 gomodel:YeastPathways_PWY3O-242/6a4c244800005963."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/149; endpoint types: /individuals/148/type; /individuals/149/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-151_14456e0d2bfd	gomodel:YeastPathways_PWY3O-242/6a4c244800006096	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006096 RO:0002233 gomodel:YeastPathways_PWY3O-242/6a4c244800006097."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/150; endpoint types: /individuals/268/type; /individuals/269/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-152_b348605a6df1	gomodel:YeastPathways_PWY3O-242/6a4c244800005945	RO:0002413	gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005945 RO:0002413 gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/151; endpoint types: /individuals/132/type; /individuals/101/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-153_40e66af69404	gomodel:YeastPathways_PWY3O-242/6a4c244800005945	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005962	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005945 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005962."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/152; endpoint types: /individuals/132/type; /individuals/148/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-154_196e739ffae1	gomodel:YeastPathways_PWY3O-242/6a4c244800006043	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006043 RO:0002234 gomodel:YeastPathways_PWY3O-242/6a4c244800006045."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/153; endpoint types: /individuals/221/type; /individuals/223/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-155_5564a6d37836	gomodel:RXN3O-364	RO:0002233	CHEBI:17283	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN3O-364 RO:0002233 gomodel:CHEBI_17283_RXN-10938."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/154; endpoint types: /individuals/36/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-157_b9a7669453a3	gomodel:RXN-10938	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10938 BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/156; endpoint types: /individuals/34/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-158_02c7d865d04b	SGD:S000005050	pathwaymech:enables	gomodel:YeastPathways_PWY3O-242/6a4c244800006005	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006005 RO:0002333 gomodel:YeastPathways_PWY3O-242/6a4c244800006010."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/157; endpoint types: /individuals/188/type; /individuals/192/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-159_24d84fa7a0e2	gomodel:2.7.1.68-RXN	RO:0002413	gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.68-RXN RO:0002413 gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/158; endpoint types: /individuals/103/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-160_b846544b4340	gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN RO:0002233 gomodel:CHEBI_15377_PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/159; endpoint types: /individuals/33/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-161_fdeebfe19a98	SGD:S000005050	pathwaymech:enables	gomodel:YeastPathways_PWY3O-242/6a4c244800006112	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006112 RO:0002333 gomodel:YeastPathways_PWY3O-242/6a4c244800006116."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/160; endpoint types: /individuals/283/type; /individuals/286/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-162_bc0fc25b151c	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006061	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006061."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/161; endpoint types: /individuals/100/type; /individuals/238/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-163_5954445de239	gomodel:YeastPathways_PWY3O-242/6a4c244800006096	RO:0002413	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006096 RO:0002413 gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/162; endpoint types: /individuals/268/type; /individuals/100/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-164_032a676fb61c	gomodel:2.7.1.68-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.68-RXN RO:0002233 gomodel:CHEBI_30616_2.7.1.68-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/163; endpoint types: /individuals/103/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-165_3e4e648d5d28	gomodel:YeastPathways_PWY3O-242/6a4c244800006043	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005927	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006043 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005927."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/164; endpoint types: /individuals/221/type; /individuals/116/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-166_929d74ca3308	gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN	RO:0002233	CHEBI:18348	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN RO:0002233 gomodel:CHEBI_18348_2.7.1.68-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/165; endpoint types: /individuals/33/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-167_7a33226a9db5	gomodel:YeastPathways_PWY3O-242/6a4c244800006024	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006024 RO:0002233 gomodel:YeastPathways_PWY3O-242/6a4c244800006025."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/166; endpoint types: /individuals/204/type; /individuals/205/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-168_85ab0dbaf1eb	gomodel:YeastPathways_PWY3O-242/6a4c244800006043	RO:0002233	CHEBI:18348	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006043 RO:0002233 gomodel:CHEBI_18348_2.7.1.68-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/167; endpoint types: /individuals/221/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-169_583c2e1bddf0	gomodel:YeastPathways_PWY3O-242/6a4c244800006024	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006024 BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/168; endpoint types: /individuals/204/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-171_823a5ff7566a	gomodel:YeastPathways_PWY3O-242/6a4c244800005984	RO:0002413	gomodel:RXN-10961	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005984 RO:0002413 gomodel:RXN-10961."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/170; endpoint types: /individuals/168/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-172_4e0b434fa7d1	gomodel:YeastPathways_PWY3O-242/6a4c244800006061	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006061 BFO:0000066 gomodel:YeastPathways_PWY3O-242/6a4c244800006068."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/171; endpoint types: /individuals/238/type; /individuals/242/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-173_caf6023e6088	gomodel:YeastPathways_PWY3O-242/6a4c244800005927	RO:0002234	CHEBI:57880	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005927 RO:0002234 gomodel:CHEBI_57880_RXN-10961."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/172; endpoint types: /individuals/116/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-174_ca0279b956ea	gomodel:RXN3O-364	RO:0002234	CHEBI:57880	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN3O-364 RO:0002234 gomodel:CHEBI_57880_RXN3O-364."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/173; endpoint types: /individuals/36/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-175_8254734369e3	gomodel:YeastPathways_PWY3O-242/6a4c244800005962	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005927	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005962 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005927."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/174; endpoint types: /individuals/148/type; /individuals/116/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-176_9c482ed7e2dc	gomodel:YeastPathways_PWY3O-242/6a4c244800006132	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006132 BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/175; endpoint types: /individuals/300/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-177_8a2b2df4af60	gomodel:YeastPathways_PWY3O-242/6a4c244800005962	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005962 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005945."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/176; endpoint types: /individuals/148/type; /individuals/132/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-178_52e3a83711d1	gomodel:YeastPathways_PWY3O-242/6a4c244800005945	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005984	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005945 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005984."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/177; endpoint types: /individuals/132/type; /individuals/168/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-179_27fea981672f	gomodel:YeastPathways_PWY3O-242/6a4c244800006096	RO:0002234	CHEBI:57880	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006096 RO:0002234 gomodel:CHEBI_57880_RXN3O-364."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/178; endpoint types: /individuals/268/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-180_6985cfd25e3c	gomodel:YeastPathways_PWY3O-242/6a4c244800006132	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006132 RO:0002233 gomodel:YeastPathways_PWY3O-242/6a4c244800006133."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/179; endpoint types: /individuals/300/type; /individuals/301/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-181_e81fb777376a	gomodel:YeastPathways_PWY3O-242/6a4c244800005945	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005945 RO:0002234 gomodel:YeastPathways_PWY3O-242/6a4c244800005947."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/180; endpoint types: /individuals/132/type; /individuals/134/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-182_f77a81543680	gomodel:YeastPathways_PWY3O-242/6a4c244800005962	RO:0002413	gomodel:RXN-10961	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005962 RO:0002413 gomodel:RXN-10961."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/181; endpoint types: /individuals/148/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-183_b6f0fa2aac42	SGD:S000001695	pathwaymech:enables	gomodel:YeastPathways_PWY3O-242/6a4c244800006079	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006079 RO:0002333 gomodel:YeastPathways_PWY3O-242/6a4c244800006084."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/182; endpoint types: /individuals/253/type; /individuals/256/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-184_df6b943a0add	gomodel:YeastPathways_PWY3O-242/6a4c244800005927	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005927 RO:0002233 gomodel:YeastPathways_PWY3O-242/6a4c244800005928."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/183; endpoint types: /individuals/116/type; /individuals/117/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-185_e57080a48486	gomodel:YeastPathways_PWY3O-242/6a4c244800006151	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006151 RO:0002234 gomodel:YeastPathways_PWY3O-242/6a4c244800006153."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/184; endpoint types: /individuals/317/type; /individuals/319/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-186_314721dd470f	gomodel:2.7.1.68-RXN	RO:0002233	CHEBI:17526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.68-RXN RO:0002233 gomodel:CHEBI_17526_1-PHOSPHATIDYLINOSITOL-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/185; endpoint types: /individuals/103/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-187_5288139eecaa	gomodel:YeastPathways_PWY3O-242/6a4c244800006005	RO:0002413	gomodel:RXN-10961	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006005 RO:0002413 gomodel:RXN-10961."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/186; endpoint types: /individuals/188/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-188_2d5763f37303	gomodel:RXN3O-364	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN3O-364 RO:0002234 gomodel:CHEBI_43474_RXN3O-364."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/187; endpoint types: /individuals/36/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-189_c165e7eae978	gomodel:YeastPathways_PWY3O-242/6a4c244800006061	RO:0002233	CHEBI:17283	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006061 RO:0002233 gomodel:CHEBI_17283_RXN-10938."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/188; endpoint types: /individuals/238/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-190_4f9e6a976ccf	gomodel:YeastPathways_PWY3O-242/6a4c244800006096	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006096 BFO:0000066 gomodel:YeastPathways_PWY3O-242/6a4c244800006101."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/189; endpoint types: /individuals/268/type; /individuals/272/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-191_f352c081f36c	gomodel:YeastPathways_PWY3O-242/6a4c244800005984	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005984 BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/190; endpoint types: /individuals/168/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-192_7e5441e816db	gomodel:2.7.1.150-RXN	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.150-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/191; endpoint types: /individuals/102/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-193_ae3ddd187f81	gomodel:2.7.1.68-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.68-RXN RO:0002234 gomodel:CHEBI_15378_2.7.1.68-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/192; endpoint types: /individuals/103/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-194_9fc3942319b3	gomodel:2.7.1.68-RXN	BFO:0000050	GO:0046854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.68-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-242/YeastPathways_PWY3O-242."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/193; endpoint types: /individuals/103/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-195_b596fed3ecd1	gomodel:2.7.1.150-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.150-RXN RO:0002234 gomodel:CHEBI_15378_2.7.1.150-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/194; endpoint types: /individuals/102/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-196_68b8ea4d29af	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	RO:0002234	CHEBI:17283	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN RO:0002234 gomodel:CHEBI_17283_1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/195; endpoint types: /individuals/100/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-197_f0eee0e2c1ed	gomodel:YeastPathways_PWY3O-242/6a4c244800006024	RO:0002233	CHEBI:18348	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006024 RO:0002233 gomodel:CHEBI_18348_2.7.1.68-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/196; endpoint types: /individuals/204/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-198_d4793bcac458	gomodel:YeastPathways_PWY3O-242/6a4c244800006005	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006005 RO:0002234 gomodel:YeastPathways_PWY3O-242/6a4c244800006007."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/197; endpoint types: /individuals/188/type; /individuals/190/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-199_593bcd6a281e	gomodel:RXN-10961	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10961 RO:0002234 gomodel:CHEBI_43474_RXN-10961."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/198; endpoint types: /individuals/35/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-200_676b54d10afe	gomodel:RXN-10961	RO:0002413	gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10961 RO:0002413 gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/199; endpoint types: /individuals/35/type; /individuals/101/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-201_820239085ca0	gomodel:RXN-10961	RO:0002234	CHEBI:57880	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10961 RO:0002234 gomodel:CHEBI_57880_RXN-10961."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/200; endpoint types: /individuals/35/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-202_800d42744194	SGD:S000005635	pathwaymech:enables	gomodel:YeastPathways_PWY3O-242/6a4c244800005927	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005927 RO:0002333 gomodel:YeastPathways_PWY3O-242/6a4c244800005931."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/201; endpoint types: /individuals/116/type; /individuals/119/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-203_ec18767010d6	gomodel:2.7.1.68-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006024	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.68-RXN RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006024."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/202; endpoint types: /individuals/103/type; /individuals/204/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-204_62be8e7a821f	gomodel:YeastPathways_PWY3O-242/6a4c244800006112	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006112 RO:0002234 gomodel:YeastPathways_PWY3O-242/6a4c244800006114."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/203; endpoint types: /individuals/283/type; /individuals/285/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-205_5d39ad54ec97	gomodel:2.7.1.150-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.150-RXN RO:0002234 gomodel:CHEBI_456216_2.7.1.150-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/204; endpoint types: /individuals/102/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-206_ece70de643b9	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	RO:0002233	CHEBI:57880	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN RO:0002233 gomodel:CHEBI_57880_RXN3O-364."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/205; endpoint types: /individuals/100/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-207_1c42a01016f6	gomodel:YeastPathways_PWY3O-242/6a4c244800005984	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005984 RO:0002234 gomodel:YeastPathways_PWY3O-242/6a4c244800005986."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/206; endpoint types: /individuals/168/type; /individuals/170/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-208_af591433fa90	gomodel:RXN-10961	RO:0002233	CHEBI:17526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10961 RO:0002233 gomodel:CHEBI_17526_1-PHOSPHATIDYLINOSITOL-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/207; endpoint types: /individuals/35/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-209_6341717a3ddb	gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005945."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/208; endpoint types: /individuals/101/type; /individuals/132/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-211_44b2c124a89e	gomodel:2.7.1.150-RXN	RO:0002233	CHEBI:17283	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.150-RXN RO:0002233 gomodel:CHEBI_17283_RXN-10938."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/210; endpoint types: /individuals/102/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-212_bc2a5a9e283c	gomodel:YeastPathways_PWY3O-242/6a4c244800006079	RO:0002413	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006079 RO:0002413 gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/211; endpoint types: /individuals/253/type; /individuals/100/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-213_e63e5c7f414e	gomodel:2.7.1.150-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800006112	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.150-RXN RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800006112."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/212; endpoint types: /individuals/102/type; /individuals/283/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-214_945f217b6f35	gomodel:YeastPathways_PWY3O-242/6a4c244800005945	RO:0002234	CHEBI:57880	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005945 RO:0002234 gomodel:CHEBI_57880_RXN-10961."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/213; endpoint types: /individuals/132/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-215_540ab0881bf2	gomodel:2.7.1.68-RXN	RO:0002234	CHEBI:18348	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:2.7.1.68-RXN RO:0002234 gomodel:CHEBI_18348_2.7.1.68-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/214; endpoint types: /individuals/103/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-216_9f7e610d6c10	gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN RO:0002233 gomodel:CHEBI_30616_1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/215; endpoint types: /individuals/100/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-217_feb086071643	SGD:S000005211	pathwaymech:enables	gomodel:YeastPathways_PWY3O-242/6a4c244800005962	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800005962 RO:0002333 gomodel:YeastPathways_PWY3O-242/6a4c244800005966."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/216; endpoint types: /individuals/148/type; /individuals/152/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-219_7034703829ec	SGD:S000005635	pathwaymech:enables	gomodel:YeastPathways_PWY3O-242/6a4c244800006132	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006132 RO:0002333 gomodel:YeastPathways_PWY3O-242/6a4c244800006136."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/218; endpoint types: /individuals/300/type; /individuals/303/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-220_964c0c27c24e	gomodel:RXN-10961	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005984	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10961 RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005984."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/219; endpoint types: /individuals/35/type; /individuals/168/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-221_8a51e26e0a96	gomodel:YeastPathways_PWY3O-242/6a4c244800006043	RO:0002413	gomodel:RXN-10961	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006043 RO:0002413 gomodel:RXN-10961."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/220; endpoint types: /individuals/221/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-222_caacc9182172	gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-242/6a4c244800005945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN RO:0002413 gomodel:YeastPathways_PWY3O-242/6a4c244800005945."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/221; endpoint types: /individuals/33/type; /individuals/132/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_location-6606181be439_6361ff10dd7b	SGD:S000001915	RO:0001025	GO:0005774	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P34756	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11889142); ECO:0000269 (PubMed:18653468); ECO:0000269 (PubMed:19037259); ECO:0000269 (PubMed:9763421) Topology: Peripheral membrane protein. Source qualification: Localization to the vacuole membrane requires VAC14 and FIG4	"[{""reference_id"": ""UniProtKB:P34756"", ""source_assertion"": ""UniProtKB:P34756 annotates location Vacuole membrane (SL-0271)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1138/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P34756"", ""source_assertion"": ""UniProtKB:P34756 has the exact SGD cross-reference SGD:S000001915."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1138/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P34756"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P34756 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_location-fd7996c97083_6ac8ba16bd26	SGD:S000001915	RO:0001025	GO:0010008	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P34756	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11889142); ECO:0000269 (PubMed:9763421) Topology: Peripheral membrane protein. Source qualification: Localization to the vacuole membrane requires VAC14 and FIG4	"[{""reference_id"": ""UniProtKB:P34756"", ""source_assertion"": ""UniProtKB:P34756 annotates location Endosome membrane (SL-0100)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1138/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P34756"", ""source_assertion"": ""UniProtKB:P34756 has the exact SGD cross-reference SGD:S000001915."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1138/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P34756"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P34756 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_location-eb9b238c6956_35f5d8734d99	SGD:S000002616	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38994	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:22562153) Topology: Peripheral membrane protein. Source qualification: Forms dynamic oligomeric patches at the cell membrane (PubMed:22562153). Localization to the cell membrane is dependent on its ability to bind substrate (PubMed:22562153)	"[{""reference_id"": ""UniProtKB:P38994"", ""source_assertion"": ""UniProtKB:P38994 annotates location Cell membrane (SL-0039)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1531/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38994"", ""source_assertion"": ""UniProtKB:P38994 has the exact SGD cross-reference SGD:S000002616."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1531/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38994"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38994 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_location-3f6d3e12f5f5_a2f9e8fe9d59	SGD:S000001695	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32368	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11514624); ECO:0000269 (PubMed:11792713); ECO:0000269 (PubMed:8314848) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P32368"", ""source_assertion"": ""UniProtKB:P32368 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/893/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32368"", ""source_assertion"": ""UniProtKB:P32368 has the exact SGD cross-reference SGD:S000001695."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/893/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32368"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32368 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_location-0d3746baabc8_c4835649212f	SGD:S000001695	RO:0001025	GO:0000139	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32368	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:8314848) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P32368"", ""source_assertion"": ""UniProtKB:P32368 annotates location Golgi apparatus membrane (SL-0134)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/893/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32368"", ""source_assertion"": ""UniProtKB:P32368 has the exact SGD cross-reference SGD:S000001695."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/893/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32368"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32368 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_location-6048f4ba1136_1ecd57f80e31	SGD:S000005269	RO:0001025	GO:0005774	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P42837	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11950935); ECO:0000269 (PubMed:14528018); ECO:0000269 (PubMed:18653468); ECO:0000269 (PubMed:19037259) Topology: Peripheral membrane protein. Source qualification: Localized to the limiting membrane of the vacuole. Localization requires VAC14 and FAB1	"[{""reference_id"": ""UniProtKB:P42837"", ""source_assertion"": ""UniProtKB:P42837 annotates location Vacuole membrane (SL-0271)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1837/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P42837"", ""source_assertion"": ""UniProtKB:P42837 has the exact SGD cross-reference SGD:S000005269."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1837/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P42837"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P42837 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_location-cd53364af9ae_ea71041ba81c	SGD:S000003871	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47147	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P47147"", ""source_assertion"": ""UniProtKB:P47147 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3884/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P47147"", ""source_assertion"": ""UniProtKB:P47147 has the exact SGD cross-reference SGD:S000003871."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3884/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P47147"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47147 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_location-11a32414566c_255017e961e3	SGD:S000005050	RO:0001025	GO:0030479	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P50942	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11094088); ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:15798181); ECO:0000269 (PubMed:16406366)	"[{""reference_id"": ""UniProtKB:P50942"", ""source_assertion"": ""UniProtKB:P50942 annotates location Cytoplasm, cytoskeleton, actin patch (SL-0008)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2062/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P50942"", ""source_assertion"": ""UniProtKB:P50942 has the exact SGD cross-reference SGD:S000005050."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2062/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P50942"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P50942 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_location-36e68d6751b1_fef09fd085f4	SGD:S000003636	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P42951	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12361950) Topology: Peripheral membrane protein. Source qualification: Located at both the plasma and vacuolar membrane	"[{""reference_id"": ""UniProtKB:P42951"", ""source_assertion"": ""UniProtKB:P42951 annotates location Cell membrane (SL-0039)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1846/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P42951"", ""source_assertion"": ""UniProtKB:P42951 has the exact SGD cross-reference SGD:S000003636."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1846/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P42951"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P42951 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_location-4807a3ce66d5_6b3fff71fcf2	SGD:S000003636	RO:0001025	GO:0005774	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P42951	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12361950); ECO:0000269 (PubMed:12523934) Topology: Peripheral membrane protein. Source qualification: Located at both the plasma and vacuolar membrane	"[{""reference_id"": ""UniProtKB:P42951"", ""source_assertion"": ""UniProtKB:P42951 annotates location Vacuole membrane (SL-0271)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1846/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P42951"", ""source_assertion"": ""UniProtKB:P42951 has the exact SGD cross-reference SGD:S000003636."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1846/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P42951"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P42951 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_location-8ffd16f53ce8_fcd2cae740a9	SGD:S000004230	RO:0001025	GO:0032588	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P22543	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11157979) Topology: Peripheral membrane protein.	"[{""reference_id"": ""UniProtKB:P22543"", ""source_assertion"": ""UniProtKB:P22543 annotates location Golgi apparatus, trans-Golgi network membrane (SL-0267)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/596/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P22543"", ""source_assertion"": ""UniProtKB:P22543 has the exact SGD cross-reference SGD:S000004230."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/596/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P22543"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P22543 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_location-aeb47a674586_7ac9d5efd4b0	SGD:S000004230	RO:0001025	GO:0010008	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P22543	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11157979) Topology: Peripheral membrane protein.	"[{""reference_id"": ""UniProtKB:P22543"", ""source_assertion"": ""UniProtKB:P22543 annotates location Endosome membrane (SL-0100)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/596/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P22543"", ""source_assertion"": ""UniProtKB:P22543 has the exact SGD cross-reference SGD:S000004230."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/596/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P22543"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P22543 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_location-dbf02379bcc9_874c04165942	SGD:S000001264	RO:0001025	GO:0030479	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40559	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P40559"", ""source_assertion"": ""UniProtKB:P40559 annotates location Cytoplasm, cytoskeleton, actin patch (SL-0008)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1760/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P40559"", ""source_assertion"": ""UniProtKB:P40559 has the exact SGD cross-reference SGD:S000001264."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1760/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40559"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40559 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_location-d0a7f1814647_33bbe11f73d0	SGD:S000005635	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12271	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11094088); ECO:0000269 (PubMed:14562095) Source qualification: Cytoplasmic punctate structures. Hyperosmotic stress causes translocation to actin patches	"[{""reference_id"": ""UniProtKB:Q12271"", ""source_assertion"": ""UniProtKB:Q12271 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3039/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q12271"", ""source_assertion"": ""UniProtKB:Q12271 has the exact SGD cross-reference SGD:S000005635."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3039/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q12271"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12271 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_location-75d0ff3bad50_86a47185e3b2	SGD:S000005426	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q08227	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11116155) Topology: Peripheral membrane protein. Orientation: Cytoplasmic side.	"[{""reference_id"": ""UniProtKB:Q08227"", ""source_assertion"": ""UniProtKB:Q08227 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4244/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q08227"", ""source_assertion"": ""UniProtKB:Q08227 has the exact SGD cross-reference SGD:S000005426."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4244/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q08227"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q08227 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_location-8d54affae2d0_ced7dcae70c2	SGD:S000005211	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39104	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:8194527)	"[{""reference_id"": ""UniProtKB:P39104"", ""source_assertion"": ""UniProtKB:P39104 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1552/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P39104"", ""source_assertion"": ""UniProtKB:P39104 has the exact SGD cross-reference SGD:S000005211."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1552/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P39104"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39104 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_location-7bca50ea296e_32ea3894da30	SGD:S000005211	RO:0001025	GO:0005802	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39104	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:19898464)	"[{""reference_id"": ""UniProtKB:P39104"", ""source_assertion"": ""UniProtKB:P39104 annotates location Golgi apparatus, trans-Golgi network (SL-0266)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1552/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P39104"", ""source_assertion"": ""UniProtKB:P39104 has the exact SGD cross-reference SGD:S000005211."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1552/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P39104"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39104 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_location-8aa8513cd905_70168fb04390	gomodel:RXN-10938	BFO:0000066	GO:0005774	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P42837	Activity compartment supported by an inspected functional annotation. ECO:0000269 (PubMed:11950935); ECO:0000269 (PubMed:14528018); ECO:0000269 (PubMed:16492811); ECO:0000269 (PubMed:19037259). Alternative isoenzymes may function elsewhere.	"[{""reference_id"": ""UniProtKB:P42837"", ""source_assertion"": ""UniProtKB:P42837 describes the corresponding catalytic function in the vacuolar membrane; this projection applies to the activity enabled by SGD:S000005269."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1837/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P42837"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P42837 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-048_a72540060fbb	gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN BFO:0000066 gomodel:reaction_PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/47; endpoint types: /individuals/33/type; /individuals/96/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-170_848517c41b31	gomodel:RXN-10961	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN-10961 BFO:0000066 gomodel:reaction_RXN-10961_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/169; endpoint types: /individuals/35/type; /individuals/98/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-210_138be3b79e27	gomodel:RXN3O-364	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:RXN3O-364 BFO:0000066 gomodel:reaction_RXN3O-364_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/209; endpoint types: /individuals/36/type; /individuals/99/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-032_bdd129b1bf3e	gomodel:YeastPathways_PWY3O-242/6a4c244800006005	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006005 BFO:0000066 gomodel:YeastPathways_PWY3O-242/6a4c244800006013."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/31; endpoint types: /individuals/188/type; /individuals/193/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_edge-218_15e2b2e293c8	gomodel:YeastPathways_PWY3O-242/6a4c244800006112	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-242		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-242/6a4c244800006112 BFO:0000066 gomodel:YeastPathways_PWY3O-242/6a4c244800006119."", ""source_locator"": ""./YeastPathways_PWY3O-242.json#/facts/217; endpoint types: /individuals/283/type; /individuals/287/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-242"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json"", ""title"": ""SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_cofactor-1a7af23a9903_690f5ee31890	SGD:S000001915	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P34756	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P34756"", ""source_assertion"": ""UniProtKB:P34756 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1138/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P34756"", ""source_assertion"": ""UniProtKB:P34756 has the exact SGD cross-reference SGD:S000001915."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1138/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P34756"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P34756 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_cofactor-84bba178c035_0384f1b93630	SGD:S000001915	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P34756	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P34756"", ""source_assertion"": ""UniProtKB:P34756 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1138/comments/0/cofactors/1""}, {""reference_id"": ""UniProtKB:P34756"", ""source_assertion"": ""UniProtKB:P34756 has the exact SGD cross-reference SGD:S000001915."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1138/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P34756"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P34756 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_cofactor-d15373a3657e_f43409628878	SGD:S000005269	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P42837	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:14528018)	"[{""reference_id"": ""UniProtKB:P42837"", ""source_assertion"": ""UniProtKB:P42837 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1837/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P42837"", ""source_assertion"": ""UniProtKB:P42837 has the exact SGD cross-reference SGD:S000005269."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1837/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P42837"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P42837 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_cofactor-756fa324a457_41c65cf968ff	SGD:S000005050	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P50942	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (PROSITE-ProRule:PRU01427)	"[{""reference_id"": ""UniProtKB:P50942"", ""source_assertion"": ""UniProtKB:P50942 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2062/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P50942"", ""source_assertion"": ""UniProtKB:P50942 has the exact SGD cross-reference SGD:S000005050."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2062/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P50942"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P50942 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_cofactor-73f85e0f7ccc_9add4661692f	SGD:S000003636	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P42951	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:12361950)	"[{""reference_id"": ""UniProtKB:P42951"", ""source_assertion"": ""UniProtKB:P42951 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1846/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P42951"", ""source_assertion"": ""UniProtKB:P42951 has the exact SGD cross-reference SGD:S000003636."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1846/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P42951"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P42951 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_cofactor-7346357c7799_a84734c2560b	SGD:S000003636	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P42951	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:12361950)	"[{""reference_id"": ""UniProtKB:P42951"", ""source_assertion"": ""UniProtKB:P42951 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1846/comments/0/cofactors/1""}, {""reference_id"": ""UniProtKB:P42951"", ""source_assertion"": ""UniProtKB:P42951 has the exact SGD cross-reference SGD:S000003636."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1846/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P42951"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P42951 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_cofactor-ae7579cba48e_a0cc85a26340	SGD:S000001264	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40559	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (PROSITE-ProRule:PRU01427)	"[{""reference_id"": ""UniProtKB:P40559"", ""source_assertion"": ""UniProtKB:P40559 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1760/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P40559"", ""source_assertion"": ""UniProtKB:P40559 has the exact SGD cross-reference SGD:S000001264."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1760/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P40559"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40559 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_cofactor-3906cb2e23c2_da121019c774	SGD:S000005635	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12271	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (PROSITE-ProRule:PRU01427)	"[{""reference_id"": ""UniProtKB:Q12271"", ""source_assertion"": ""UniProtKB:Q12271 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3039/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:Q12271"", ""source_assertion"": ""UniProtKB:Q12271 has the exact SGD cross-reference SGD:S000005635."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3039/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q12271"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12271 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-242_cofactor-2258e99edff1_dc2a45eb5f43	SGD:S000005426	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q08227	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (PROSITE-ProRule:PRU01427)	"[{""reference_id"": ""UniProtKB:Q08227"", ""source_assertion"": ""UniProtKB:Q08227 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4244/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:Q08227"", ""source_assertion"": ""UniProtKB:Q08227 has the exact SGD cross-reference SGD:S000005426."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4244/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q08227"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q08227 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-001_720040b1ed12	SGD:S000002554	pathwaymech:enables	gomodel:ETHANOLAMINE-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:ETHANOLAMINE-KINASE-RXN RO:0002333 gomodel:YDR147W-MONOMER_ETHANOLAMINE-KINASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/0; endpoint types: /individuals/13/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-002_aa6b0185cf02	gomodel:2.7.7.14-RXN	BFO:0000050	GO:0046474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:2.7.7.14-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-259/YeastPathways_PWY3O-259."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/1; endpoint types: /individuals/42/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-003_33732622ac6d	gomodel:ETHANOLAMINE-KINASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:ETHANOLAMINE-KINASE-RXN RO:0002234 gomodel:CHEBI_15378_ETHANOLAMINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/2; endpoint types: /individuals/13/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-004_2e1098b8551e	gomodel:2.7.7.14-RXN	RO:0002233	CHEBI:58190	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:2.7.7.14-RXN RO:0002233 gomodel:CHEBI_58190_ETHANOLAMINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/3; endpoint types: /individuals/42/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-005_7400be217841	gomodel:ETHANOLAMINE-KINASE-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:ETHANOLAMINE-KINASE-RXN RO:0002233 gomodel:CHEBI_30616_ETHANOLAMINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/4; endpoint types: /individuals/13/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-007_80570563c252	SGD:S000001165	pathwaymech:enables	gomodel:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN RO:0002333 gomodel:YHR123W-MONOMER_ETHANOLAMINEPHOSPHOTRANSFERASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/6; endpoint types: /individuals/14/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-008_121185d65e5a	gomodel:ETHANOLAMINE-KINASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:ETHANOLAMINE-KINASE-RXN BFO:0000066 gomodel:reaction_ETHANOLAMINE-KINASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/7; endpoint types: /individuals/13/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-009_a00326c04763	gomodel:ETHANOLAMINE-KINASE-RXN	RO:0002234	CHEBI:58190	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:ETHANOLAMINE-KINASE-RXN RO:0002234 gomodel:CHEBI_58190_ETHANOLAMINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/8; endpoint types: /individuals/13/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-010_4c4aaf9862f4	gomodel:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN	RO:0002233	CHEBI:17815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_17815_ETHANOLAMINEPHOSPHOTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/9; endpoint types: /individuals/14/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-011_77f6d2dd3e94	gomodel:ETHANOLAMINE-KINASE-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:ETHANOLAMINE-KINASE-RXN RO:0002234 gomodel:CHEBI_456216_ETHANOLAMINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/10; endpoint types: /individuals/13/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-012_86f141292778	SGD:S000003239	pathwaymech:enables	gomodel:2.7.7.14-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:2.7.7.14-RXN RO:0002333 gomodel:YGR007W-MONOMER_2.7.7.14-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/11; endpoint types: /individuals/42/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-013_733729fd9700	gomodel:2.7.7.14-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:2.7.7.14-RXN BFO:0000066 gomodel:reaction_2.7.7.14-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/12; endpoint types: /individuals/42/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-014_268d1f1ddd16	gomodel:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN	RO:0002234	CHEBI:60377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_60377_ETHANOLAMINEPHOSPHOTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/13; endpoint types: /individuals/14/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-015_f40c53553887	gomodel:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_15378_ETHANOLAMINEPHOSPHOTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/14; endpoint types: /individuals/14/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-016_534db848f562	gomodel:ETHANOLAMINE-KINASE-RXN	RO:0002233	CHEBI:57603	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:ETHANOLAMINE-KINASE-RXN RO:0002233 gomodel:CHEBI_57603_ETHANOLAMINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/15; endpoint types: /individuals/13/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-017_e5feb88cb5fa	gomodel:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN	RO:0002234	CHEBI:16038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_16038_ETHANOLAMINEPHOSPHOTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/16; endpoint types: /individuals/14/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-018_110f03473b9d	gomodel:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN	BFO:0000050	GO:0046474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-259/YeastPathways_PWY3O-259."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/17; endpoint types: /individuals/14/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-019_9b698e783d6a	gomodel:2.7.7.14-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:2.7.7.14-RXN RO:0002233 gomodel:CHEBI_15378_2.7.7.14-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/18; endpoint types: /individuals/42/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-020_09d07b1ba8d0	gomodel:2.7.7.14-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:2.7.7.14-RXN RO:0002234 gomodel:CHEBI_29888_2.7.7.14-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/19; endpoint types: /individuals/42/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-021_1e73ceb7c4e3	gomodel:2.7.7.14-RXN	RO:0002234	CHEBI:57876	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:2.7.7.14-RXN RO:0002234 gomodel:CHEBI_57876_2.7.7.14-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/20; endpoint types: /individuals/42/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-022_39bd459e45c0	gomodel:2.7.7.14-RXN	RO:0002233	CHEBI:37563	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:2.7.7.14-RXN RO:0002233 gomodel:CHEBI_37563_2.7.7.14-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/21; endpoint types: /individuals/42/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-023_03f7a3baf06f	gomodel:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN	RO:0002233	CHEBI:57876	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_57876_2.7.7.14-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/22; endpoint types: /individuals/14/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_edge-024_3e5c33cedd78	gomodel:ETHANOLAMINE-KINASE-RXN	BFO:0000050	GO:0046474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-259		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_assertion"": ""The model asserts gomodel:ETHANOLAMINE-KINASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-259/YeastPathways_PWY3O-259."", ""source_locator"": ""./YeastPathways_PWY3O-259.json#/facts/23; endpoint types: /individuals/13/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-259"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-259.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis II Kennedy pathway PWY3O-259"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_location-63acee327d3f_999b3aacfd4d	SGD:S000002554	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q03764	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q03764"", ""source_assertion"": ""UniProtKB:Q03764 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4094/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q03764"", ""source_assertion"": ""UniProtKB:Q03764 has the exact SGD cross-reference SGD:S000002554."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4094/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q03764"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q03764 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_location-014157e4297f_a9d9d88ebad7	SGD:S000001165	RO:0001025	GO:0000139	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P22140	Physical protein location from reviewed UniProt. evidence code not specified by source Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P22140"", ""source_assertion"": ""UniProtKB:P22140 annotates location Golgi apparatus membrane (SL-0134)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/575/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P22140"", ""source_assertion"": ""UniProtKB:P22140 has the exact SGD cross-reference SGD:S000001165."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/575/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P22140"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P22140 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_location-79aae7513507_16a70ce30f06	SGD:S000003239	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33412	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P33412"", ""source_assertion"": ""UniProtKB:P33412 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3468/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P33412"", ""source_assertion"": ""UniProtKB:P33412 has the exact SGD cross-reference SGD:S000003239."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3468/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P33412"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P33412 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_location-caefac4d5be0_b505a81276e9	SGD:S000003239	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33412	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P33412"", ""source_assertion"": ""UniProtKB:P33412 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3468/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P33412"", ""source_assertion"": ""UniProtKB:P33412 has the exact SGD cross-reference SGD:S000003239."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3468/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P33412"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P33412 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-259_cofactor-883f33f57dbc_da4990b24216	SGD:S000001165	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P22140	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:1847919)	"[{""reference_id"": ""UniProtKB:P22140"", ""source_assertion"": ""UniProtKB:P22140 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/575/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P22140"", ""source_assertion"": ""UniProtKB:P22140 has the exact SGD cross-reference SGD:S000001165."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/575/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P22140"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P22140 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-001_e636ef3d3ec1	gomodel:2.1.1.71-RXN	RO:0002233	CHEBI:59789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2.1.1.71-RXN RO:0002233 gomodel:CHEBI_59789_2.1.1.71-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/0; endpoint types: /individuals/101/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-002_89db0ed01736	gomodel:2.1.1.17-RXN	RO:0002233	CHEBI:16038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2.1.1.17-RXN RO:0002233 gomodel:CHEBI_16038_PHOSPHASERDECARB-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/1; endpoint types: /individuals/100/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-003_b57a24b78429	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485	RO:0002413	gomodel:2.1.1.17-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485 RO:0002413 gomodel:2.1.1.17-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/2; endpoint types: /individuals/111/type; /individuals/100/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-004_ba2d79a7804a	gomodel:PGPPHOSPHA-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PGPPHOSPHA-RXN RO:0002233 gomodel:CHEBI_15377_PGPPHOSPHA-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/3; endpoint types: /individuals/30/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-005_3f0d5862ce2e	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485	RO:0002233	CHEBI:11750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485 RO:0002233 gomodel:CHEBI_11750_PHOSPHASERSYN-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/4; endpoint types: /individuals/111/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-006_6824869c3f37	gomodel:CARDIOLIPSYN-RXN	BFO:0000050	GO:0008654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CARDIOLIPSYN-RXN BFO:0000050 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/YeastPathways_PHOSLIPSYN2-PWY-1."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/5; endpoint types: /individuals/0/type; /individuals/102/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-007_f0f6da53f2f2	gomodel:PGPPHOSPHA-RXN	RO:0002234	CHEBI:64716	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PGPPHOSPHA-RXN RO:0002234 gomodel:CHEBI_64716_PGPPHOSPHA-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/6; endpoint types: /individuals/30/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-009_891da566727e	gomodel:PHOSPHASERSYN-RXN	RO:0002234	CHEBI:11750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002234 gomodel:CHEBI_11750_PHOSPHASERSYN-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/8; endpoint types: /individuals/33/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-010_bf420a851783	gomodel:RXN3O-349	BFO:0000050	GO:0008654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-349 BFO:0000050 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/YeastPathways_PHOSLIPSYN2-PWY-1."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/9; endpoint types: /individuals/34/type; /individuals/102/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-011_0029bd077ea4	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485	BFO:0000050	GO:0008654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485 BFO:0000050 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/YeastPathways_PHOSLIPSYN2-PWY-1."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/10; endpoint types: /individuals/111/type; /individuals/102/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-013_bb9980bb5d05	gomodel:RXN3O-349	RO:0002233	CHEBI:17152	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-349 RO:0002233 gomodel:CHEBI_17152_2.1.1.71-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/12; endpoint types: /individuals/34/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-014_2ebe0a9e0580	SGD:S000003402	pathwaymech:enables	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485 RO:0002333 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007488."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/13; endpoint types: /individuals/111/type; /individuals/114/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-015_c6b8fdf755ba	gomodel:PHOSPHASERDECARB-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERDECARB-RXN RO:0002234 gomodel:CHEBI_16526_PHOSPHASERDECARB-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/14; endpoint types: /individuals/32/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-016_153de57184d8	gomodel:PHOSPHASERSYN-RXN	RO:0002233	CHEBI:33384	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002233 gomodel:CHEBI_33384_PHOSPHASERSYN-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/15; endpoint types: /individuals/33/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-017_af782447a827	SGD:S000005113	pathwaymech:enables	gomodel:PHOSPHASERDECARB-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERDECARB-RXN RO:0002333 gomodel:YNL169C-MONOMER_PHOSPHASERDECARB-RXN_controller."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/16; endpoint types: /individuals/32/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-018_de1dea944375	gomodel:2.1.1.71-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2.1.1.71-RXN RO:0002234 gomodel:CHEBI_15378_2.1.1.71-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/17; endpoint types: /individuals/101/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-019_4224f75d4b0a	gomodel:PHOSPHASERDECARB-RXN	BFO:0000050	GO:0008654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERDECARB-RXN BFO:0000050 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/YeastPathways_PHOSLIPSYN2-PWY-1."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/18; endpoint types: /individuals/32/type; /individuals/102/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-020_2442ed1525c4	SGD:S000003834	pathwaymech:enables	gomodel:2.1.1.71-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2.1.1.71-RXN RO:0002333 gomodel:YJR073C-MONOMER_2.1.1.71-RXN_controller."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/19; endpoint types: /individuals/101/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-021_fd18a178883b	gomodel:PGPPHOSPHA-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PGPPHOSPHA-RXN RO:0002234 gomodel:CHEBI_43474_PGPPHOSPHA-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/20; endpoint types: /individuals/30/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-022_be36c2b02b21	gomodel:PHOSPHASERDECARB-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERDECARB-RXN RO:0002233 gomodel:CHEBI_15378_PHOSPHASERDECARB-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/21; endpoint types: /individuals/32/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-023_fb249a95547b	gomodel:PHOSPHASERSYN-RXN	RO:0002413	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002413 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/22; endpoint types: /individuals/33/type; /individuals/111/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-024_fd5f57d03fb0	gomodel:PHOSPHAGLYPSYN-RXN	BFO:0000050	GO:0008654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHAGLYPSYN-RXN BFO:0000050 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/YeastPathways_PHOSLIPSYN2-PWY-1."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/23; endpoint types: /individuals/31/type; /individuals/102/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-026_e78503ad5554	gomodel:PHOSPHASERSYN-RXN	BFO:0000050	GO:0008654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERSYN-RXN BFO:0000050 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/YeastPathways_PHOSLIPSYN2-PWY-1."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/25; endpoint types: /individuals/33/type; /individuals/102/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-027_8e3cfabc9fe7	gomodel:2.1.1.71-RXN	BFO:0000050	GO:0008654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2.1.1.71-RXN BFO:0000050 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/YeastPathways_PHOSLIPSYN2-PWY-1."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/26; endpoint types: /individuals/101/type; /individuals/102/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-028_22633c093ff9	gomodel:2.1.1.71-RXN	RO:0002234	CHEBI:17152	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2.1.1.71-RXN RO:0002234 gomodel:CHEBI_17152_2.1.1.71-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/27; endpoint types: /individuals/101/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-029_28283277994c	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485 RO:0002234 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007487."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/28; endpoint types: /individuals/111/type; /individuals/113/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-030_245d99a6b84c	gomodel:2.1.1.17-RXN	RO:0002233	CHEBI:59789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2.1.1.17-RXN RO:0002233 gomodel:CHEBI_59789_2.1.1.17-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/29; endpoint types: /individuals/100/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-031_e7aa40956ea3	gomodel:2.1.1.71-RXN	RO:0002413	gomodel:RXN3O-349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2.1.1.71-RXN RO:0002413 gomodel:RXN3O-349."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/30; endpoint types: /individuals/101/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-033_627b853fec33	gomodel:RXN3O-349	RO:0002234	CHEBI:16110	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-349 RO:0002234 gomodel:CHEBI_16110_RXN3O-349."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/32; endpoint types: /individuals/34/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-034_8f674965e40b	gomodel:PGPPHOSPHA-RXN	BFO:0000050	GO:0008654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PGPPHOSPHA-RXN BFO:0000050 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/YeastPathways_PHOSLIPSYN2-PWY-1."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/33; endpoint types: /individuals/30/type; /individuals/102/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-035_2eb0b488a057	gomodel:2.1.1.71-RXN	RO:0002233	CHEBI:15958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2.1.1.71-RXN RO:0002233 gomodel:CHEBI_15958_2.1.1.17-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/34; endpoint types: /individuals/101/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-036_7425afacd63c	gomodel:PHOSPHAGLYPSYN-RXN	RO:0002234	CHEBI:37393	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHAGLYPSYN-RXN RO:0002234 gomodel:CHEBI_37393_PHOSPHAGLYPSYN-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/35; endpoint types: /individuals/31/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-037_6ea7fc7dfe34	gomodel:RXN3O-349	RO:0002234	CHEBI:57856	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-349 RO:0002234 gomodel:CHEBI_57856_RXN3O-349."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/36; endpoint types: /individuals/34/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-038_bdb643c98f39	gomodel:PHOSPHASERDECARB-RXN	RO:0002413	gomodel:2.1.1.17-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERDECARB-RXN RO:0002413 gomodel:2.1.1.17-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/37; endpoint types: /individuals/32/type; /individuals/100/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-040_d345c6c0c740	gomodel:PGPPHOSPHA-RXN	RO:0002233	CHEBI:37393	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PGPPHOSPHA-RXN RO:0002233 gomodel:CHEBI_37393_PHOSPHAGLYPSYN-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/39; endpoint types: /individuals/30/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-041_69dbfa6bd171	gomodel:PHOSPHASERSYN-RXN	RO:0002234	CHEBI:60377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002234 gomodel:CHEBI_60377_PHOSPHASERSYN-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/40; endpoint types: /individuals/33/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-042_792b3bd67c51	gomodel:PHOSPHAGLYPSYN-RXN	RO:0002233	CHEBI:57597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHAGLYPSYN-RXN RO:0002233 gomodel:CHEBI_57597_PHOSPHAGLYPSYN-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/41; endpoint types: /individuals/31/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-044_7d355fcf0993	SGD:S000000510	pathwaymech:enables	gomodel:PHOSPHAGLYPSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHAGLYPSYN-RXN RO:0002333 gomodel:YCL004W-MONOMER_PHOSPHAGLYPSYN-RXN_controller."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/43; endpoint types: /individuals/31/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-045_7123a0dcecc6	gomodel:PHOSPHAGLYPSYN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHAGLYPSYN-RXN RO:0002234 gomodel:CHEBI_15378_PHOSPHAGLYPSYN-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/44; endpoint types: /individuals/31/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-046_c6ed0bdc91db	SGD:S000001142	pathwaymech:enables	gomodel:PGPPHOSPHA-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PGPPHOSPHA-RXN RO:0002333 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007476."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/45; endpoint types: /individuals/30/type; /individuals/103/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-047_ca551965e2f0	gomodel:PHOSPHASERDECARB-RXN	RO:0002233	CHEBI:11750	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERDECARB-RXN RO:0002233 gomodel:CHEBI_11750_PHOSPHASERSYN-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/46; endpoint types: /individuals/32/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-048_db81da224ef8	gomodel:PGPPHOSPHA-RXN	RO:0002413	gomodel:CARDIOLIPSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PGPPHOSPHA-RXN RO:0002413 gomodel:CARDIOLIPSYN-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/47; endpoint types: /individuals/30/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-049_52a7adde279e	SGD:S000002301	pathwaymech:enables	gomodel:CARDIOLIPSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CARDIOLIPSYN-RXN RO:0002333 gomodel:YDL142C-MONOMER_CARDIOLIPSYN-RXN_controller."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/48; endpoint types: /individuals/0/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-050_6bc54755295d	SGD:S000000828	pathwaymech:enables	gomodel:PHOSPHASERSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002333 gomodel:YER026C-MONOMER_PHOSPHASERSYN-RXN_controller."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/49; endpoint types: /individuals/33/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-051_f80a8be9a938	gomodel:2.1.1.17-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2.1.1.17-RXN RO:0002234 gomodel:CHEBI_15378_2.1.1.17-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/50; endpoint types: /individuals/100/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-052_ef2af4d4ecad	gomodel:2.1.1.17-RXN	RO:0002413	gomodel:2.1.1.71-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2.1.1.17-RXN RO:0002413 gomodel:2.1.1.71-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/51; endpoint types: /individuals/100/type; /individuals/101/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-053_1d52d1897e08	gomodel:PHOSPHAGLYPSYN-RXN	RO:0002234	CHEBI:60377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHAGLYPSYN-RXN RO:0002234 gomodel:CHEBI_60377_PHOSPHAGLYPSYN-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/52; endpoint types: /individuals/31/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-054_94de6ac37325	SGD:S000003389	pathwaymech:enables	gomodel:2.1.1.17-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2.1.1.17-RXN RO:0002333 gomodel:YGR157W-MONOMER_2.1.1.17-RXN_controller."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/53; endpoint types: /individuals/100/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-055_3c206a95cd76	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485	RO:0002234	CHEBI:16038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485 RO:0002234 gomodel:CHEBI_16038_PHOSPHASERDECARB-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/54; endpoint types: /individuals/111/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-056_d1de894ab17e	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485 RO:0002233 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007486."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/55; endpoint types: /individuals/111/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-057_3713f486f69b	gomodel:PHOSPHAGLYPSYN-RXN	RO:0002233	CHEBI:17962	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHAGLYPSYN-RXN RO:0002233 gomodel:CHEBI_17962_PHOSPHAGLYPSYN-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/56; endpoint types: /individuals/31/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-058_2f87cf467291	gomodel:PHOSPHASERDECARB-RXN	RO:0002234	CHEBI:16038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERDECARB-RXN RO:0002234 gomodel:CHEBI_16038_PHOSPHASERDECARB-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/57; endpoint types: /individuals/32/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-059_36ae7702c42f	gomodel:RXN3O-349	RO:0002233	CHEBI:59789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-349 RO:0002233 gomodel:CHEBI_59789_RXN3O-349."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/58; endpoint types: /individuals/34/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-060_df4fb6bad9b9	gomodel:2.1.1.17-RXN	RO:0002234	CHEBI:15958	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2.1.1.17-RXN RO:0002234 gomodel:CHEBI_15958_2.1.1.17-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/59; endpoint types: /individuals/100/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-063_4d6c349aa5fb	gomodel:PHOSPHASERSYN-RXN	RO:0002233	CHEBI:17962	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002233 gomodel:CHEBI_17962_PHOSPHASERSYN-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/62; endpoint types: /individuals/33/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-065_2d5157ff5e5f	gomodel:2.1.1.71-RXN	RO:0002234	CHEBI:57856	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2.1.1.71-RXN RO:0002234 gomodel:CHEBI_57856_2.1.1.71-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/64; endpoint types: /individuals/101/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-066_2be0c94381b3	SGD:S000003834	pathwaymech:enables	gomodel:RXN3O-349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-349 RO:0002333 gomodel:YJR073C-MONOMER_RXN3O-349_controller."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/65; endpoint types: /individuals/34/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-067_3a7fcedfcb8f	gomodel:2.1.1.17-RXN	BFO:0000050	GO:0008654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2.1.1.17-RXN BFO:0000050 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/YeastPathways_PHOSLIPSYN2-PWY-1."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/66; endpoint types: /individuals/100/type; /individuals/102/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-070_cd1c5f575e1b	gomodel:PHOSPHASERSYN-RXN	RO:0002413	gomodel:PHOSPHASERDECARB-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002413 gomodel:PHOSPHASERDECARB-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/69; endpoint types: /individuals/33/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-072_d38046f3fb42	gomodel:PHOSPHAGLYPSYN-RXN	RO:0002413	gomodel:PGPPHOSPHA-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHAGLYPSYN-RXN RO:0002413 gomodel:PGPPHOSPHA-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/71; endpoint types: /individuals/31/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-073_e8c4f858624f	gomodel:2.1.1.17-RXN	RO:0002234	CHEBI:57856	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:2.1.1.17-RXN RO:0002234 gomodel:CHEBI_57856_2.1.1.17-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/72; endpoint types: /individuals/100/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_edge-074_5696c0cfe5bb	gomodel:PHOSPHASERSYN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_assertion"": ""The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002234 gomodel:CHEBI_15378_PHOSPHASERSYN-RXN."", ""source_locator"": ""./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/73; endpoint types: /individuals/33/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PHOSLIPSYN2-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json"", ""title"": ""SGD GO-CAM phospholipid biosynthesis model"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_location-56e56579324d_8b3aa7556b30	SGD:S000003402	RO:0001025	GO:0000139	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53037	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03209); ECO:0000269 (PubMed:7890739) Topology: Peripheral membrane protein. Orientation: Cytoplasmic side.	"[{""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 annotates location Golgi apparatus membrane (SL-0134)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2090/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 has the exact SGD cross-reference SGD:S000003402."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2090/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53037"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53037 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_location-6207f3362a39_7833457c93b3	SGD:S000003402	RO:0001025	GO:0010008	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53037	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03209); ECO:0000269 (PubMed:20016005) Topology: Peripheral membrane protein. Orientation: Cytoplasmic side.	"[{""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 annotates location Endosome membrane (SL-0100)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2090/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 has the exact SGD cross-reference SGD:S000003402."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2090/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53037"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53037 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_location-0e11315efbd5_1bb295e20ce9	SGD:S000005113	RO:0001025	GO:0005743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39006	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03208); ECO:0000269 (PubMed:14576278); ECO:0000269 (PubMed:22984266); ECO:0000269 (PubMed:23124206); ECO:0000269 (PubMed:29290583); ECO:0000269 (PubMed:3005242); ECO:0000269 (PubMed:33718843); ECO:0000305 (PubMed:34818062); molecular form: Phosphatidylserine decarboxylase 1 beta chain. Topology: Single-pass membrane protein. Orientation: Intermembrane side.	"[{""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 annotates location Mitochondrion inner membrane (SL-0168); molecular form: Phosphatidylserine decarboxylase 1 beta chain."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 has the exact SGD cross-reference SGD:S000005113."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 annotates location Mitochondrion inner membrane (SL-0168); molecular form: Phosphatidylserine decarboxylase 1 alpha chain."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/comments/2/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P39006"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39006 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_location-03ed1a7e29e9_d9b8c8a45f04	SGD:S000005113	RO:0001025	GO:0005811	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39006	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:34818062) Source qualification: Localizes to sites of lipid droplet formation on the endoplasmic reticulum membrane	"[{""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 annotates location Lipid droplet (SL-0154)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/comments/3/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 has the exact SGD cross-reference SGD:S000005113."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P39006"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39006 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_location-31e0ba4b0e8a_6d45137c25d5	SGD:S000005113	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39006	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:29290583); ECO:0000269 (PubMed:34818062) Source qualification: Localizes to sites of lipid droplet formation on the endoplasmic reticulum membrane	"[{""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/comments/3/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 has the exact SGD cross-reference SGD:S000005113."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P39006"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39006 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_location-7af3240e9a0a_bce500ddde0e	SGD:S000003834	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05375	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03216); ECO:0000269 (PubMed:14562095) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P05375"", ""source_assertion"": ""UniProtKB:P05375 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/106/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P05375"", ""source_assertion"": ""UniProtKB:P05375 has the exact SGD cross-reference SGD:S000003834."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/106/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P05375"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P05375 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_location-50a9b7360617_e05109c9464c	SGD:S000003834	RO:0001025	GO:0031966	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05375	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03216); ECO:0000269 (PubMed:14576278) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P05375"", ""source_assertion"": ""UniProtKB:P05375 annotates location Mitochondrion membrane (SL-0171)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/106/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P05375"", ""source_assertion"": ""UniProtKB:P05375 has the exact SGD cross-reference SGD:S000003834."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/106/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P05375"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P05375 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_location-e78d2d77dc53_add97101f1e1	SGD:S000000510	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P25578	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:9545322); ECO:0000269 (PubMed:9799363)	"[{""reference_id"": ""UniProtKB:P25578"", ""source_assertion"": ""UniProtKB:P25578 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3372/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P25578"", ""source_assertion"": ""UniProtKB:P25578 has the exact SGD cross-reference SGD:S000000510."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3372/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P25578"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P25578 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_location-eca549141a78_2f3e1c76816e	SGD:S000001142	RO:0001025	GO:0005743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38812	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961); ECO:0000269 (PubMed:20485265) Topology: Peripheral membrane protein. Orientation: Matrix side.	"[{""reference_id"": ""UniProtKB:P38812"", ""source_assertion"": ""UniProtKB:P38812 annotates location Mitochondrion inner membrane (SL-0168)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3637/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38812"", ""source_assertion"": ""UniProtKB:P38812 has the exact SGD cross-reference SGD:S000001142."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3637/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38812"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38812 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_location-e723aab0b021_f6a76d4146c5	SGD:S000002301	RO:0001025	GO:0005743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q07560	Physical protein location from reviewed UniProt. ECO:0000305 (PubMed:9442089) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:Q07560"", ""source_assertion"": ""UniProtKB:Q07560 annotates location Mitochondrion inner membrane (SL-0168)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2821/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q07560"", ""source_assertion"": ""UniProtKB:Q07560 has the exact SGD cross-reference SGD:S000002301."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2821/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q07560"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q07560 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_location-6585f7696d57_e127c38eba5e	SGD:S000000828	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08456	Physical protein location from reviewed UniProt. evidence code not specified by source Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P08456"", ""source_assertion"": ""UniProtKB:P08456 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/205/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P08456"", ""source_assertion"": ""UniProtKB:P08456 has the exact SGD cross-reference SGD:S000000828."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/205/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P08456"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P08456 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_location-558857e0f0ad_46862c16bd61	SGD:S000000828	RO:0001025	GO:0005741	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08456	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:3005242) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P08456"", ""source_assertion"": ""UniProtKB:P08456 annotates location Mitochondrion outer membrane (SL-0172)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/205/comments/1/subcellularLocations/2; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P08456"", ""source_assertion"": ""UniProtKB:P08456 has the exact SGD cross-reference SGD:S000000828."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/205/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P08456"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P08456 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_location-415fdbf92779_3651c15c2778	SGD:S000003389	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05374	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03217); ECO:0000269 (PubMed:14562095) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P05374"", ""source_assertion"": ""UniProtKB:P05374 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/105/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P05374"", ""source_assertion"": ""UniProtKB:P05374 has the exact SGD cross-reference SGD:S000003389."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/105/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P05374"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P05374 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_location-8b23f76d01f7_843ce64197ce	gomodel:PHOSPHASERDECARB-RXN	BFO:0000066	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39006	Activity compartment supported by an inspected functional annotation. ECO:0000255 (HAMAP-Rule:MF_03208); ECO:0000269 (PubMed:11294902); ECO:0000269 (PubMed:17976194); ECO:0000269 (PubMed:23045528); ECO:0000269 (PubMed:23124206); ECO:0000269 (PubMed:25829489); ECO:0000269 (PubMed:29290583); ECO:0000269 (PubMed:30926815); ECO:0000269 (PubMed:34818062); ECO:0000269 (PubMed:8227017); ECO:0000269 (PubMed:8407984); ECO:0000269 (PubMed:8530379). Alternative isoenzymes may function elsewhere.	"[{""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 describes the corresponding catalytic function in the mitochondrion; this projection applies to the activity enabled by SGD:S000005113."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P39006"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39006 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_location-07b4ae96df73_8eeedbd8f709	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485	BFO:0000066	GO:0000139	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53037	Activity compartment supported by an inspected functional annotation. ECO:0000255 (HAMAP-Rule:MF_03209); ECO:0000269 (PubMed:11294902); ECO:0000269 (PubMed:20016005); ECO:0000269 (PubMed:24366873); ECO:0000269 (PubMed:7890739); ECO:0000269 (PubMed:7890740). Alternative isoenzymes may function elsewhere.	"[{""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 describes the corresponding catalytic function in the Golgi membrane; this projection applies to the activity enabled by SGD:S000003402."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2090/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53037"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53037 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_location-dc530c02e175_e88513678155	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485	BFO:0000066	GO:0010008	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53037	Activity compartment supported by an inspected functional annotation. ECO:0000255 (HAMAP-Rule:MF_03209); ECO:0000269 (PubMed:11294902); ECO:0000269 (PubMed:20016005); ECO:0000269 (PubMed:24366873); ECO:0000269 (PubMed:7890739); ECO:0000269 (PubMed:7890740). Alternative isoenzymes may function elsewhere.	"[{""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 describes the corresponding catalytic function in the endosome membrane; this projection applies to the activity enabled by SGD:S000003402."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2090/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53037"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53037 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_function-150b9563e5b7_28422bea8d7c	gomodel:CARDIOLIPSYN-RXN	RO:0002233	CHEBI:58332	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q07560	Yeast CRD1 is the CMP-forming cardiolipin synthase: CDP-diacylglycerol and phosphatidylglycerol are inputs; cardiolipin, CMP and H+ are outputs. The imported bacterial glycerol-forming chemistry is superseded.	"[{""reference_id"": ""UniProtKB:Q07560"", ""source_assertion"": ""a CDP-1,2-diacyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + CMP + H(+)"", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/Q07560.json [sha256:4776cb2392de0f791dccac79c1e4ce3b203239abfb46d2dcab9ae4ffada2c30d] #/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q07560"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q07560 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_function-3ba285489e02_fc82954f2a20	gomodel:CARDIOLIPSYN-RXN	RO:0002233	CHEBI:64716	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q07560	Yeast CRD1 is the CMP-forming cardiolipin synthase: CDP-diacylglycerol and phosphatidylglycerol are inputs; cardiolipin, CMP and H+ are outputs. The imported bacterial glycerol-forming chemistry is superseded.	"[{""reference_id"": ""UniProtKB:Q07560"", ""source_assertion"": ""a CDP-1,2-diacyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + CMP + H(+)"", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/Q07560.json [sha256:4776cb2392de0f791dccac79c1e4ce3b203239abfb46d2dcab9ae4ffada2c30d] #/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q07560"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q07560 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_function-c2e26f49cef9_b356e8cb214c	gomodel:CARDIOLIPSYN-RXN	RO:0002234	CHEBI:62237	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q07560	Yeast CRD1 is the CMP-forming cardiolipin synthase: CDP-diacylglycerol and phosphatidylglycerol are inputs; cardiolipin, CMP and H+ are outputs. The imported bacterial glycerol-forming chemistry is superseded.	"[{""reference_id"": ""UniProtKB:Q07560"", ""source_assertion"": ""a CDP-1,2-diacyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + CMP + H(+)"", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/Q07560.json [sha256:4776cb2392de0f791dccac79c1e4ce3b203239abfb46d2dcab9ae4ffada2c30d] #/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q07560"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q07560 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_function-2642c755072b_410036d2428f	gomodel:CARDIOLIPSYN-RXN	RO:0002234	CHEBI:60377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q07560	Yeast CRD1 is the CMP-forming cardiolipin synthase: CDP-diacylglycerol and phosphatidylglycerol are inputs; cardiolipin, CMP and H+ are outputs. The imported bacterial glycerol-forming chemistry is superseded.	"[{""reference_id"": ""UniProtKB:Q07560"", ""source_assertion"": ""a CDP-1,2-diacyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + CMP + H(+)"", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/Q07560.json [sha256:4776cb2392de0f791dccac79c1e4ce3b203239abfb46d2dcab9ae4ffada2c30d] #/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q07560"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q07560 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_function-0e1babd2fe8b_f2d9f6afb191	gomodel:CARDIOLIPSYN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q07560	Yeast CRD1 is the CMP-forming cardiolipin synthase: CDP-diacylglycerol and phosphatidylglycerol are inputs; cardiolipin, CMP and H+ are outputs. The imported bacterial glycerol-forming chemistry is superseded.	"[{""reference_id"": ""UniProtKB:Q07560"", ""source_assertion"": ""a CDP-1,2-diacyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + CMP + H(+)"", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/Q07560.json [sha256:4776cb2392de0f791dccac79c1e4ce3b203239abfb46d2dcab9ae4ffada2c30d] #/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q07560"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q07560 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_cofactor-05e8264b38ea_574463187015	SGD:S000003402	pathwaymech:has_cofactor	CHEBI:45360	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:45360|UniProtKB:P53037	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The cofactor note explicitly describes a covalently bound pyruvoyl group; use the exact group class rather than free pyruvate. UniProt evidence: ECO:0000250 (UniProtKB:P0A8K1); ECO:0000255 (HAMAP-Rule:MF_03209) Binds 1 pyruvoyl group covalently per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P0A8K1); ECO:0000255 (HAMAP-Rule:MF_03209)	"[{""reference_id"": ""CHEBI:45360"", ""source_assertion"": ""ChEBI labels CHEBI:45360 as pyruvoyl group."", ""source_locator"": ""chebi.obo [Term] id: CHEBI:45360; name: pyruvoyl group""}, {""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 cross-references CHEBI:15361, but its note specifies a covalently bound pyruvoyl group; that group is projected to CHEBI:45360."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2090/comments/0/cofactors/0; /results/2090/comments/0/note""}, {""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 has the exact SGD cross-reference SGD:S000003402."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2090/uniProtKBCrossReferences/0""}]"	"[{""id"": ""CHEBI:45360"", ""source_sha256"": ""6cd3c7f18d8b22c577e110e00008fb288d8f5b34424bbe5011858747062f9dd9"", ""source_version"": ""ChEBI release 255"", ""title"": ""ChEBI CHEBI:45360: pyruvoyl group"", ""url"": ""https://ftp.ebi.ac.uk/pub/databases/chebi/ontology/chebi.obo""}, {""id"": ""UniProtKB:P53037"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53037 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_cofactor-789dceaf9d43_846a7cd8244e	SGD:S000003402	pathwaymech:has_cofactor	CHEBI:29108	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53037	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The cofactor note explicitly describes a covalently bound pyruvoyl group; use the exact group class rather than free pyruvate. UniProt evidence: ECO:0000255 (PROSITE-ProRule:PRU00041)	"[{""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 annotates CHEBI:29108 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2090/comments/1/cofactors/0""}, {""reference_id"": ""UniProtKB:P53037"", ""source_assertion"": ""UniProtKB:P53037 has the exact SGD cross-reference SGD:S000003402."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2090/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53037"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53037 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_cofactor-4f48b265fa2b_81f276da64be	SGD:S000005113	pathwaymech:has_cofactor	CHEBI:45360	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:45360|UniProtKB:P39006	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The cofactor note explicitly describes a covalently bound pyruvoyl group; use the exact group class rather than free pyruvate. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03208) Binds 1 pyruvoyl group covalently per subunit. UniProt note evidence: ECO:0000255 (HAMAP-Rule:MF_03208)	"[{""reference_id"": ""CHEBI:45360"", ""source_assertion"": ""ChEBI labels CHEBI:45360 as pyruvoyl group."", ""source_locator"": ""chebi.obo [Term] id: CHEBI:45360; name: pyruvoyl group""}, {""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 cross-references CHEBI:15361, but its note specifies a covalently bound pyruvoyl group; that group is projected to CHEBI:45360."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1539/comments/0/cofactors/0; /results/1539/comments/0/note""}, {""reference_id"": ""UniProtKB:P39006"", ""source_assertion"": ""UniProtKB:P39006 has the exact SGD cross-reference SGD:S000005113."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1539/uniProtKBCrossReferences/0""}]"	"[{""id"": ""CHEBI:45360"", ""source_sha256"": ""6cd3c7f18d8b22c577e110e00008fb288d8f5b34424bbe5011858747062f9dd9"", ""source_version"": ""ChEBI release 255"", ""title"": ""ChEBI CHEBI:45360: pyruvoyl group"", ""url"": ""https://ftp.ebi.ac.uk/pub/databases/chebi/ontology/chebi.obo""}, {""id"": ""UniProtKB:P39006"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P39006 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_cofactor-2bcf0541bed9_32ab10925bea	SGD:S000002301	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q07560	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The caution corrects the historical species attribution of a sequence; the current reviewed yeast entry and magnesium annotation remain applicable. UniProt evidence: ECO:0000269 (PubMed:2171667)	"[{""reference_id"": ""UniProtKB:Q07560"", ""source_assertion"": ""UniProtKB:Q07560 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2821/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:Q07560"", ""source_assertion"": ""UniProtKB:Q07560 has the exact SGD cross-reference SGD:S000002301."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2821/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q07560"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q07560 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_cofactor-2a3454b9a114_a8d0928cbe44	SGD:S000000828	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08456	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:6088519); ECO:0000269 (PubMed:6274497) Divalent metal cations; Mn(2+) or Mg(2+). UniProt note evidence: ECO:0000269 (PubMed:6088519)	"[{""reference_id"": ""UniProtKB:P08456"", ""source_assertion"": ""UniProtKB:P08456 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/205/comments/0/cofactors/0; /results/205/comments/0/note""}, {""reference_id"": ""UniProtKB:P08456"", ""source_assertion"": ""UniProtKB:P08456 has the exact SGD cross-reference SGD:S000000828."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/205/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P08456"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P08456 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PHOSLIPSYN2-PWY-1_cofactor-827c72dec25c_c30970a9ba46	SGD:S000000828	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08456	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:6088519) Divalent metal cations; Mn(2+) or Mg(2+). UniProt note evidence: ECO:0000269 (PubMed:6088519)	"[{""reference_id"": ""UniProtKB:P08456"", ""source_assertion"": ""UniProtKB:P08456 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/205/comments/0/cofactors/1; /results/205/comments/0/note""}, {""reference_id"": ""UniProtKB:P08456"", ""source_assertion"": ""UniProtKB:P08456 has the exact SGD cross-reference SGD:S000000828."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/205/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P08456"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P08456 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:WikiPathways_WP71_causal-review-1_592098c7188c	CHEBI:16110	pathwaymech:consumes	WikiPathways:WP71/id3a707ae4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP71		"[{""reference_id"": ""WikiPathways:WP71"", ""source_assertion"": ""GPML id3a707ae4 connects normalized CHEBI:16110 as an input of interaction id3a707ae4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id3a707ae4']/Graphics; /Pathway/DataNode[@GraphId='ee13a']""}]"	"[{""id"": ""WikiPathways:WP71"", ""source_sha256"": ""4f47195c00087954a101bee443f5ae9a87c40c7a0f8c0d64f5496a61a4b624cf"", ""source_version"": ""WP71_r20260926102110"", ""title"": ""WP71 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP71/WP71.gpml""}]"	""
pathwaymech:WikiPathways_WP71_causal-review-2_49dd9386b1d8	WikiPathways:WP71/id3a707ae4	pathwaymech:produces	CHEBI:29089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP71		"[{""reference_id"": ""WikiPathways:WP71"", ""source_assertion"": ""GPML id3a707ae4 connects normalized CHEBI:29089 as an output of interaction id3a707ae4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id3a707ae4']/Graphics; /Pathway/DataNode[@GraphId='c42d6']""}]"	"[{""id"": ""WikiPathways:WP71"", ""source_sha256"": ""4f47195c00087954a101bee443f5ae9a87c40c7a0f8c0d64f5496a61a4b624cf"", ""source_version"": ""WP71_r20260926102110"", ""title"": ""WP71 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP71/WP71.gpml""}]"	""
pathwaymech:WikiPathways_WP71_causal-review-3_c27a41dcd827	WikiPathways:WP71/id3a707ae4	pathwaymech:produces	CHEBI:15354	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP71		"[{""reference_id"": ""WikiPathways:WP71"", ""source_assertion"": ""GPML id153723c8 connects normalized CHEBI:15354 as an output of interaction id3a707ae4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id153723c8']/Graphics; /Pathway/DataNode[@GraphId='ad11f']""}]"	"[{""id"": ""WikiPathways:WP71"", ""source_sha256"": ""4f47195c00087954a101bee443f5ae9a87c40c7a0f8c0d64f5496a61a4b624cf"", ""source_version"": ""WP71_r20260926102110"", ""title"": ""WP71 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP71/WP71.gpml""}]"	""
pathwaymech:WikiPathways_WP71_causal-review-4_fc47c4bdbfe7	WikiPathways:WP71/id3a707ae4	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP71		"[{""reference_id"": ""WikiPathways:WP71"", ""source_assertion"": ""GPML id153723c8 connects normalized CHEBI:15378 as an output of interaction id3a707ae4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id153723c8']/Graphics; /Pathway/DataNode[@GraphId='ca3e3']""}]"	"[{""id"": ""WikiPathways:WP71"", ""source_sha256"": ""4f47195c00087954a101bee443f5ae9a87c40c7a0f8c0d64f5496a61a4b624cf"", ""source_version"": ""WP71_r20260926102110"", ""title"": ""WP71 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP71/WP71.gpml""}]"	""
pathwaymech:WikiPathways_WP71_causal-review-5_f736ed3c543e	SGD:S000001739	pathwaymech:catalyzes	WikiPathways:WP71/id3a707ae4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP71		"[{""reference_id"": ""WikiPathways:WP71"", ""source_assertion"": ""GPML id8293ebf6 connects normalized SGD:S000001739 as a catalyst of interaction id3a707ae4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id8293ebf6']/Graphics; /Pathway/DataNode[@GraphId='e31']""}]"	"[{""id"": ""WikiPathways:WP71"", ""source_sha256"": ""4f47195c00087954a101bee443f5ae9a87c40c7a0f8c0d64f5496a61a4b624cf"", ""source_version"": ""WP71_r20260926102110"", ""title"": ""WP71 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP71/WP71.gpml""}]"	""
pathwaymech:WikiPathways_WP71_causal-review-6_8f6aae18fe18	CHEBI:15377	pathwaymech:consumes	WikiPathways:WP71/id3a707ae4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP71		"[{""reference_id"": ""WikiPathways:WP71"", ""source_assertion"": ""GPML idb1638a08 connects normalized CHEBI:15377 as an input of interaction id3a707ae4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idb1638a08']/Graphics; /Pathway/DataNode[@GraphId='bc483']""}]"	"[{""id"": ""WikiPathways:WP71"", ""source_sha256"": ""4f47195c00087954a101bee443f5ae9a87c40c7a0f8c0d64f5496a61a4b624cf"", ""source_version"": ""WP71_r20260926102110"", ""title"": ""WP71 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP71/WP71.gpml""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-001_056dde113437	CHEBI:11851	pathwaymech:consumes	RHEA:11825	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11825		"[{""reference_id"": ""RHEA:11825"", ""source_assertion"": ""Rhea lists CHEBI:11851 on the substrates side of RHEA:11825 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11825']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11825"", ""source_version"": ""139"", ""title"": ""Rhea 2-dehydropantoate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/11825""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-002_28f32a5ec96b	CHEBI:15377	pathwaymech:consumes	RHEA:11825	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11825		"[{""reference_id"": ""RHEA:11825"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:11825 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11825']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11825"", ""source_version"": ""139"", ""title"": ""Rhea 2-dehydropantoate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/11825""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-003_733f04fb8156	CHEBI:15636	pathwaymech:consumes	RHEA:11825	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11825		"[{""reference_id"": ""RHEA:11825"", ""source_assertion"": ""Rhea lists CHEBI:15636 on the substrates side of RHEA:11825 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11825']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11825"", ""source_version"": ""139"", ""title"": ""Rhea 2-dehydropantoate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/11825""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-004_5493ba8bcb94	RHEA:11825	pathwaymech:produces	CHEBI:11561	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11825		"[{""reference_id"": ""RHEA:11825"", ""source_assertion"": ""Rhea lists CHEBI:11561 on the products side of RHEA:11825 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11825']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11825"", ""source_version"": ""139"", ""title"": ""Rhea 2-dehydropantoate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/11825""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-005_b752ffffb9d1	RHEA:11825	pathwaymech:produces	CHEBI:57453	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11825		"[{""reference_id"": ""RHEA:11825"", ""source_assertion"": ""Rhea lists CHEBI:57453 on the products side of RHEA:11825 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11825']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11825"", ""source_version"": ""139"", ""title"": ""Rhea 2-dehydropantoate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/11825""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-006_f5e611088bc7	CHEBI:11561	pathwaymech:consumes	RHEA:16235	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16235		"[{""reference_id"": ""RHEA:16235"", ""source_assertion"": ""Rhea lists CHEBI:11561 on the substrates side of RHEA:16235 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16235']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16235"", ""source_version"": ""139"", ""title"": ""Rhea pantoate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16235""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-007_482831983729	CHEBI:15378	pathwaymech:consumes	RHEA:16235	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16235		"[{""reference_id"": ""RHEA:16235"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:16235 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16235']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16235"", ""source_version"": ""139"", ""title"": ""Rhea pantoate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16235""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-008_e2d225a40961	CHEBI:57783	pathwaymech:consumes	RHEA:16235	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16235		"[{""reference_id"": ""RHEA:16235"", ""source_assertion"": ""Rhea lists CHEBI:57783 on the substrates side of RHEA:16235 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16235']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16235"", ""source_version"": ""139"", ""title"": ""Rhea pantoate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16235""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-009_a14d850d178f	RHEA:16235	pathwaymech:produces	CHEBI:15980	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16235		"[{""reference_id"": ""RHEA:16235"", ""source_assertion"": ""Rhea lists CHEBI:15980 on the products side of RHEA:16235 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16235']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16235"", ""source_version"": ""139"", ""title"": ""Rhea pantoate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16235""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-010_cc685de7d38e	RHEA:16235	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16235		"[{""reference_id"": ""RHEA:16235"", ""source_assertion"": ""Rhea lists CHEBI:58349 on the products side of RHEA:16235 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16235']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16235"", ""source_version"": ""139"", ""title"": ""Rhea pantoate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16235""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-011_3c6f8922f9c8	CHEBI:15980	pathwaymech:consumes	RHEA:10913	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10913		"[{""reference_id"": ""RHEA:10913"", ""source_assertion"": ""Rhea lists CHEBI:15980 on the substrates side of RHEA:10913 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10913']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10913"", ""source_version"": ""139"", ""title"": ""Rhea pantothenate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10913""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-012_a777634562eb	CHEBI:30616	pathwaymech:consumes	RHEA:10913	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10913		"[{""reference_id"": ""RHEA:10913"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:10913 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10913']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10913"", ""source_version"": ""139"", ""title"": ""Rhea pantothenate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10913""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-013_de46c1e252ff	CHEBI:57966	pathwaymech:consumes	RHEA:10913	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10913		"[{""reference_id"": ""RHEA:10913"", ""source_assertion"": ""Rhea lists CHEBI:57966 on the substrates side of RHEA:10913 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10913']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10913"", ""source_version"": ""139"", ""title"": ""Rhea pantothenate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10913""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-014_64545cc76c24	RHEA:10913	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10913		"[{""reference_id"": ""RHEA:10913"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:10913 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10913']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10913"", ""source_version"": ""139"", ""title"": ""Rhea pantothenate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10913""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-015_4e428346f01b	RHEA:10913	pathwaymech:produces	CHEBI:29032	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10913		"[{""reference_id"": ""RHEA:10913"", ""source_assertion"": ""Rhea lists CHEBI:29032 on the products side of RHEA:10913 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10913']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10913"", ""source_version"": ""139"", ""title"": ""Rhea pantothenate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10913""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-016_bea3d188609e	RHEA:10913	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10913		"[{""reference_id"": ""RHEA:10913"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:10913 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10913']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10913"", ""source_version"": ""139"", ""title"": ""Rhea pantothenate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10913""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-017_515d3b177c3f	RHEA:10913	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10913		"[{""reference_id"": ""RHEA:10913"", ""source_assertion"": ""Rhea lists CHEBI:456215 on the products side of RHEA:10913 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10913']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10913"", ""source_version"": ""139"", ""title"": ""Rhea pantothenate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10913""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-018_0872ab1f8445	CHEBI:29032	pathwaymech:consumes	RHEA:16374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16374		"[{""reference_id"": ""RHEA:16374"", ""source_assertion"": ""Rhea lists CHEBI:29032 on the substrates side of RHEA:16374 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16374']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16374"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantothenate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16374""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-019_f135351a3dfa	CHEBI:30616	pathwaymech:consumes	RHEA:16374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16374		"[{""reference_id"": ""RHEA:16374"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:16374 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16374']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16374"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantothenate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16374""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-020_997eef15e81c	RHEA:16374	pathwaymech:produces	CHEBI:10986	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16374		"[{""reference_id"": ""RHEA:16374"", ""source_assertion"": ""Rhea lists CHEBI:10986 on the products side of RHEA:16374 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16374']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16374"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantothenate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16374""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-021_567101a59fc3	RHEA:16374	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16374		"[{""reference_id"": ""RHEA:16374"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:16374 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16374']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16374"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantothenate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16374""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-022_226c3c98c496	RHEA:16374	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16374		"[{""reference_id"": ""RHEA:16374"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:16374 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16374']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16374"", ""source_version"": ""139"", ""title"": ""Rhea phosphopantothenate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16374""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-023_d18f9d08c0fe	EC:2.1.2.11	pathwaymech:catalyzes	RHEA:11825	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11824		"[{""reference_id"": ""RHEA:11824"", ""source_assertion"": ""Rhea associates EC:2.1.2.11 with the reaction family containing RHEA:11825."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:11824"", ""source_version"": ""139"", ""title"": ""Rhea 3-methyl-2-oxobutanoate hydroxymethyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/11824""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-024_db93cd6650a7	EC:1.1.1.169	pathwaymech:catalyzes	RHEA:16235	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16233		"[{""reference_id"": ""RHEA:16233"", ""source_assertion"": ""Rhea associates EC:1.1.1.169 with the reaction family containing RHEA:16235."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:16233"", ""source_version"": ""139"", ""title"": ""Rhea 2-dehydropantoate reductase reaction"", ""url"": ""https://www.rhea-db.org/rhea/16233""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-025_58c24f8cb2ce	EC:6.3.2.1	pathwaymech:catalyzes	RHEA:10913	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10912		"[{""reference_id"": ""RHEA:10912"", ""source_assertion"": ""Rhea associates EC:6.3.2.1 with the reaction family containing RHEA:10913."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:10912"", ""source_version"": ""139"", ""title"": ""Rhea pantothenate synthetase reaction"", ""url"": ""https://www.rhea-db.org/rhea/10912""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-026_0d3a674dfe58	EC:2.7.1.33	pathwaymech:catalyzes	RHEA:16374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16373		"[{""reference_id"": ""RHEA:16373"", ""source_assertion"": ""Rhea associates EC:2.7.1.33 with the reaction family containing RHEA:16374."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:16373"", ""source_version"": ""139"", ""title"": ""Rhea pantothenate kinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/16373""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-027_865890252fa8	RHEA:10913	pathwaymech:precedes	RHEA:16374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PANTO-PWY		"[{""reference_id"": ""MetaCyc:PANTO-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:10913 before RHEA:16374 in this pathway. Shared intermediate: CHEBI:29032."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PANTO-PWY"", ""source_sha256"": ""d04374c056a484ef198189fd03c8e61ddf07b9367d52ea9a89339325813e2edf"", ""source_version"": ""22.5"", ""title"": ""MetaCyc phosphopantothenate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PANTO-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-028_a046baccdd24	RHEA:11825	pathwaymech:precedes	RHEA:16235	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PANTO-PWY		"[{""reference_id"": ""MetaCyc:PANTO-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:11825 before RHEA:16235 in this pathway. Shared intermediate: CHEBI:11561."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PANTO-PWY"", ""source_sha256"": ""d04374c056a484ef198189fd03c8e61ddf07b9367d52ea9a89339325813e2edf"", ""source_version"": ""22.5"", ""title"": ""MetaCyc phosphopantothenate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PANTO-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-029_4e0563b8a77d	RHEA:16235	pathwaymech:precedes	RHEA:10913	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PANTO-PWY		"[{""reference_id"": ""MetaCyc:PANTO-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:16235 before RHEA:10913 in this pathway. Shared intermediate: CHEBI:15980."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PANTO-PWY"", ""source_sha256"": ""d04374c056a484ef198189fd03c8e61ddf07b9367d52ea9a89339325813e2edf"", ""source_version"": ""22.5"", ""title"": ""MetaCyc phosphopantothenate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PANTO-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-030_a64aafdea5cd	UniProtKB:P0A6I3	pathwaymech:enables	RHEA:16374	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6I3		"[{""reference_id"": ""UniProtKB:P0A6I3"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A6I3 with catalytic activity for the reaction family of RHEA:16374. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A6I3"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6I3 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6I3.json""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-031_89630e28538d	CHEBI:57287	pathwaymech:inhibits	UniProtKB:P0A6I3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6I3		"[{""reference_id"": ""UniProtKB:P0A6I3"", ""source_assertion"": ""UniProt activity-regulation annotation: Regulated by feedback inhibition by CoA and its thioesters"", ""source_locator"": ""comments[commentType='ACTIVITY REGULATION'].texts""}]"	"[{""id"": ""UniProtKB:P0A6I3"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6I3 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6I3.json""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-032_98b5e311a8a3	UniProtKB:P0A6I3	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6I3		"[{""reference_id"": ""UniProtKB:P0A6I3"", ""source_assertion"": ""UniProt locates UniProtKB:P0A6I3 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A6I3"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6I3 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6I3.json""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-033_bf61882af466	UniProtKB:P0A9J4	pathwaymech:enables	RHEA:16235	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9J4		"[{""reference_id"": ""UniProtKB:P0A9J4"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A9J4 with catalytic activity for the reaction family of RHEA:16235. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A9J4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9J4 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9J4.json""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-034_64496b047e2f	UniProtKB:P0A9J4	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9J4		"[{""reference_id"": ""UniProtKB:P0A9J4"", ""source_assertion"": ""UniProt locates UniProtKB:P0A9J4 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A9J4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9J4 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9J4.json""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-035_c857c02913d0	UniProtKB:P31057	pathwaymech:enables	RHEA:11825	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31057		"[{""reference_id"": ""UniProtKB:P31057"", ""source_assertion"": ""UniProt annotates UniProtKB:P31057 with catalytic activity for the reaction family of RHEA:11825. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P31057"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P31057 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31057.json""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-036_1aca33ee7aa6	UniProtKB:P31057	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31057		"[{""reference_id"": ""UniProtKB:P31057"", ""source_assertion"": ""UniProt locates UniProtKB:P31057 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P31057"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P31057 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31057.json""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-037_a79398d68a8f	UniProtKB:P31057	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31057		"[{""reference_id"": ""UniProtKB:P31057"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P31057 (evidence: ECO:0000269). Binds 1 Mg(2+) ion per subunit. Can also use Mn(2+), Co(2+) and Zn(2+) to a lesser extent."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P31057"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P31057 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31057.json""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-038_b46c5269ec67	UniProtKB:P31057	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31057		"[{""reference_id"": ""UniProtKB:P31057"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P31057 (evidence: ECO:0000269). Binds 1 Mg(2+) ion per subunit. Can also use Mn(2+), Co(2+) and Zn(2+) to a lesser extent."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P31057"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P31057 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31057.json""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-039_b8f12c4c2deb	UniProtKB:P31057	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31057		"[{""reference_id"": ""UniProtKB:P31057"", ""source_assertion"": ""UniProt lists CHEBI:48828 as a cofactor of UniProtKB:P31057 (evidence: ECO:0000269). Binds 1 Mg(2+) ion per subunit. Can also use Mn(2+), Co(2+) and Zn(2+) to a lesser extent."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P31057"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P31057 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31057.json""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-040_10cfb443b83c	UniProtKB:P31057	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31057		"[{""reference_id"": ""UniProtKB:P31057"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P31057 (evidence: ECO:0000269). Binds 1 Mg(2+) ion per subunit. Can also use Mn(2+), Co(2+) and Zn(2+) to a lesser extent."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P31057"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P31057 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31057.json""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-041_05546049c952	UniProtKB:P31663	pathwaymech:enables	RHEA:10913	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31663		"[{""reference_id"": ""UniProtKB:P31663"", ""source_assertion"": ""UniProt annotates UniProtKB:P31663 with catalytic activity for the reaction family of RHEA:10913. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P31663"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P31663 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31663.json""}]"	""
pathwaymech:MetaCyc_PANTO-PWY_edge-042_5cc5468c56af	UniProtKB:P31663	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31663		"[{""reference_id"": ""UniProtKB:P31663"", ""source_assertion"": ""UniProt locates UniProtKB:P31663 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000305."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P31663"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P31663 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31663.json""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-001_a7a2db294721	CHEBI:57288	pathwaymech:consumes	RHEA:21037	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21037	Two acetyl-CoA molecules are condensed; the graph records participation, while the source equation supplies coefficient 2.	"[{""reference_id"": ""RHEA:21037"", ""source_assertion"": ""Rhea assigns CHEBI:57288 to the substrates of the directed reaction RHEA:21037. The source equation has coefficient 2 for acetyl-CoA."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21037']/rh:substrates; rh:contains/rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:21037"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 21037 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-002_3b3cf01a61a2	RHEA:21037	pathwaymech:produces	CHEBI:57286	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21037		"[{""reference_id"": ""RHEA:21037"", ""source_assertion"": ""Rhea assigns CHEBI:57286 to the products of the directed reaction RHEA:21037."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21037']/rh:products; rh:contains/rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:21037"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 21037 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-003_16dffa3bf43d	RHEA:21037	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21037		"[{""reference_id"": ""RHEA:21037"", ""source_assertion"": ""Rhea assigns CHEBI:57287 to the products of the directed reaction RHEA:21037."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21037']/rh:products; rh:contains/rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:21037"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 21037 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-004_d3898714b956	CHEBI:57286	pathwaymech:consumes	RHEA:45798	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45798		"[{""reference_id"": ""RHEA:45798"", ""source_assertion"": ""Rhea assigns CHEBI:57286 to the substrates of the directed reaction RHEA:45798."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/45798']/rh:substrates; rh:contains/rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:45798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 45798 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-005_bdecf7ebc2dc	CHEBI:57783	pathwaymech:consumes	RHEA:45798	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45798		"[{""reference_id"": ""RHEA:45798"", ""source_assertion"": ""Rhea assigns CHEBI:57783 to the substrates of the directed reaction RHEA:45798."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/45798']/rh:substrates; rh:contains/rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:45798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 45798 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-006_9a83edcc6b5f	CHEBI:15378	pathwaymech:consumes	RHEA:45798	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45798		"[{""reference_id"": ""RHEA:45798"", ""source_assertion"": ""Rhea assigns CHEBI:15378 to the substrates of the directed reaction RHEA:45798."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/45798']/rh:substrates; rh:contains/rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:45798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 45798 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-007_5dfd271a64a6	RHEA:45798	pathwaymech:produces	CHEBI:57315	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45798		"[{""reference_id"": ""RHEA:45798"", ""source_assertion"": ""Rhea assigns CHEBI:57315 to the products of the directed reaction RHEA:45798."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/45798']/rh:products; rh:contains/rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:45798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 45798 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-008_2e7012b0a025	RHEA:45798	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:45798		"[{""reference_id"": ""RHEA:45798"", ""source_assertion"": ""Rhea assigns CHEBI:58349 to the products of the directed reaction RHEA:45798."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/45798']/rh:products; rh:contains/rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:45798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 45798 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-009_f45f7233d5cd	CHEBI:57315	pathwaymech:consumes	RHEA:15406	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15406		"[{""reference_id"": ""RHEA:15406"", ""source_assertion"": ""Rhea assigns CHEBI:57315 to the substrates of the directed reaction RHEA:15406."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15406']/rh:substrates; rh:contains/rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:15406"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 15406 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-010_708a3861dbb2	CHEBI:8298	pathwaymech:consumes	RHEA:15406	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15406	The input is the poly[(R)-3-hydroxybutanoate] chain of length n. CHEBI:8298 is the shared polymer class, not an identifier for a particular chain length.	"[{""reference_id"": ""RHEA:15406"", ""source_assertion"": ""Rhea assigns CHEBI:8298 to the substrates of the directed reaction RHEA:15406. The substrate polymer is POLYMER:14464, [(3R)-hydroxybutanoate](n), linked to CHEBI:8298."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15406']/rh:substrates; rh:contains/rh:compound/rh:underlyingChebi; rh:polymerizationIndex""}]"	"[{""id"": ""RHEA:15406"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 15406 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-011_c69638330858	RHEA:15406	pathwaymech:produces	CHEBI:8298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15406	The output is the extended poly[(R)-3-hydroxybutanoate] chain of length n+1, distinct from the input chain state despite sharing the generic polymer class identifier.	"[{""reference_id"": ""RHEA:15406"", ""source_assertion"": ""Rhea assigns CHEBI:8298 to the products of the directed reaction RHEA:15406. The product polymer is POLYMER:14465, [(3R)-hydroxybutanoate](n+1), linked to CHEBI:8298."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15406']/rh:products; rh:contains/rh:compound/rh:underlyingChebi; rh:polymerizationIndex""}]"	"[{""id"": ""RHEA:15406"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 15406 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-012_5501b4ef4f74	RHEA:15406	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15406		"[{""reference_id"": ""RHEA:15406"", ""source_assertion"": ""Rhea assigns CHEBI:57287 to the products of the directed reaction RHEA:15406."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15406']/rh:products; rh:contains/rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:15406"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 15406 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-013_f4d05e1221fe	UniProtKB:P14611	pathwaymech:catalyzes	RHEA:21037	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:2670935|UniProtKB:P14611		"[{""reference_id"": ""UniProtKB:P14611"", ""source_assertion"": ""UniProt assigns PhaA to RHEA:21036 (ECO:0000269 and ECO:0000255) and describes condensation of two acetyl-CoA units. RHEA:21037 is the selected biosynthetic direction."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction[reactionCrossReferences.id='RHEA:21036']; comments[commentType='FUNCTION']""}, {""quote"": ""beta-ketothiolase and acetoacetyl-CoA reductase enzyme activities"", ""reference_id"": ""PMID:2670935"", ""source_locator"": ""Abstract""}]"	"[{""id"": ""PMID:2670935"", ""title"": ""Poly-beta-hydroxybutyrate biosynthesis in Alcaligenes eutrophus H16. Characterization of the genes encoding beta-ketothiolase and acetoacetyl-CoA reductase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/2670935/""}, {""id"": ""UniProtKB:P14611"", ""source_sha256"": ""f0350ba62a6ee34cb4779818b74e12706c596c04d122b415426ec5b6d94ccf12"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P14611, Cupriavidus necator H16"", ""url"": ""https://rest.uniprot.org/uniprotkb/P14611.json""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-014_faf25a726d05	UniProtKB:P14697	pathwaymech:catalyzes	RHEA:45798	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:23913421|UniProtKB:P14697		"[{""reference_id"": ""UniProtKB:P14697"", ""source_assertion"": ""UniProt assigns PhaB to the specific RHEA:45796 acetoacetyl-CoA reaction; its FUNCTION statement supports chiral reduction to (R)-3-hydroxybutyryl-CoA with ECO:0000269. RHEA:45798 is the biosynthetic direction."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction[reactionCrossReferences.id='RHEA:45796']; comments[commentType='FUNCTION']""}, {""quote"": ""PhaB forms a ternary complex with NADPH and acetoacetyl-CoA."", ""reference_id"": ""PMID:23913421"", ""source_locator"": ""Abstract""}]"	"[{""id"": ""PMID:23913421"", ""title"": ""Directed evolution and structural analysis of NADPH-dependent Acetoacetyl Coenzyme A (Acetoacetyl-CoA) reductase from Ralstonia eutropha reveals two mutations responsible for enhanced kinetics."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/23913421/""}, {""id"": ""UniProtKB:P14697"", ""source_sha256"": ""6e051efb8f2f3e64e82a612d3edaf8f5e7267a20574d4d3be501df9d0b8c73b5"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P14697, Cupriavidus necator H16"", ""url"": ""https://rest.uniprot.org/uniprotkb/P14697.json""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-015_c4df1d8fe8de	UniProtKB:P23608	pathwaymech:catalyzes	RHEA:15406	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:22369488|UniProtKB:P23608		"[{""reference_id"": ""UniProtKB:P23608"", ""source_assertion"": ""UniProt assigns PhaC to RHEA:15405 with ECO:0000250; its FUNCTION statement independently describes PHB polymerization with ECO:0000269. The directed chain-extension reaction is RHEA:15406."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction[reactionCrossReferences.id='RHEA:15405']; comments[commentType='FUNCTION']""}, {""quote"": ""catalyzes the formation of PHB from (R)-3-hydroxybutyryl-CoA"", ""reference_id"": ""PMID:22369488"", ""source_locator"": ""Abstract""}]"	"[{""id"": ""PMID:22369488"", ""title"": ""Purification of polyhydroxybutyrate synthase from its native organism, Ralstonia eutropha: implications for the initiation and elongation of polymer formation in vivo."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/22369488/""}, {""id"": ""UniProtKB:P23608"", ""source_sha256"": ""a5fbd1b61fc65f9dac2ab13a7aac95c6bcd4a8fab38267f544b1d62d57618d62"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P23608, Cupriavidus necator H16"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23608.json""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-016_e8e3565b8ba5	RHEA:21037	BFO:0000050	MetaCyc:PWY1-3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY1-3|RHEA:21037		"[{""reference_id"": ""MetaCyc:PWY1-3"", ""source_assertion"": ""MetaCyc PWY1-3 declares native reaction ACETYL-COA-ACETYLTRANSFER-RXN as a pathway member."", ""source_locator"": ""Pathway[@frameid='PWY1-3']/reaction-list/Reaction[@frameid='ACETYL-COA-ACETYLTRANSFER-RXN']""}, {""reference_id"": ""RHEA:21037"", ""source_assertion"": ""Rhea links RHEA:21039 to MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN. Master RHEA:21036 identifies RHEA:21039 as its bidirectional member and RHEA:21037 as a directional member; RHEA:21037 selects acetyl-CoA condensation."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21039']/rdfs:seeAlso; rdf:Description[@rdf:about='http://rdf.rhea-db.org/21036']/rh:bidirectionalReaction and rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:PWY1-3"", ""source_sha256"": ""3469d020b1a4685466f2739fe280849df9578d2a20e798a95bed3e847de4f03d"", ""source_version"": ""22.5"", ""title"": ""MetaCyc polyhydroxybutanoate biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY1-3""}, {""id"": ""RHEA:21037"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 21037 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-017_5209a52fbd42	RHEA:45798	BFO:0000050	MetaCyc:PWY1-3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY1-3|RHEA:45798		"[{""reference_id"": ""MetaCyc:PWY1-3"", ""source_assertion"": ""MetaCyc PWY1-3 declares native reaction RXN-5901 as a pathway member."", ""source_locator"": ""Pathway[@frameid='PWY1-3']/reaction-list/Reaction[@frameid='RXN-5901']""}, {""reference_id"": ""RHEA:45798"", ""source_assertion"": ""Rhea directly cross-references RHEA:45798 to MetaCyc:RXN-5901 in rdfs:seeAlso."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/45798']/rdfs:seeAlso[@rdf:resource='http://identifiers.org/biocyc/METACYC:RXN-5901']""}]"	"[{""id"": ""MetaCyc:PWY1-3"", ""source_sha256"": ""3469d020b1a4685466f2739fe280849df9578d2a20e798a95bed3e847de4f03d"", ""source_version"": ""22.5"", ""title"": ""MetaCyc polyhydroxybutanoate biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY1-3""}, {""id"": ""RHEA:45798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 45798 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-018_57c2d42bc302	RHEA:15406	BFO:0000050	MetaCyc:PWY1-3	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY1-3|RHEA:15406		"[{""reference_id"": ""MetaCyc:PWY1-3"", ""source_assertion"": ""MetaCyc PWY1-3 declares native reaction RXN1-42 as a pathway member."", ""source_locator"": ""Pathway[@frameid='PWY1-3']/reaction-list/Reaction[@frameid='RXN1-42']""}, {""reference_id"": ""RHEA:15406"", ""source_assertion"": ""Rhea directly cross-references RHEA:15406 to MetaCyc:RXN1-42 in rdfs:seeAlso."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15406']/rdfs:seeAlso[@rdf:resource='http://identifiers.org/biocyc/METACYC:RXN1-42']""}]"	"[{""id"": ""MetaCyc:PWY1-3"", ""source_sha256"": ""3469d020b1a4685466f2739fe280849df9578d2a20e798a95bed3e847de4f03d"", ""source_version"": ""22.5"", ""title"": ""MetaCyc polyhydroxybutanoate biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY1-3""}, {""id"": ""RHEA:15406"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 15406 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-019_30a8f3558123	RHEA:21037	pathwaymech:precedes	RHEA:45798	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY1-3|RHEA:21037|RHEA:45798		"[{""reference_id"": ""MetaCyc:PWY1-3"", ""source_assertion"": ""MetaCyc PWY1-3 declares ACETYL-COA-ACETYLTRANSFER-RXN as a predecessor of RXN-5901."", ""source_locator"": ""Pathway/reaction-ordering[Reaction/@frameid='RXN-5901']/predecessor-reactions/Reaction[@frameid='ACETYL-COA-ACETYLTRANSFER-RXN']""}, {""reference_id"": ""RHEA:21037"", ""source_assertion"": ""Rhea links RHEA:21039 to MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN. Master RHEA:21036 identifies RHEA:21039 as its bidirectional member and RHEA:21037 as a directional member; RHEA:21037 selects acetyl-CoA condensation."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/21039']/rdfs:seeAlso; rdf:Description[@rdf:about='http://rdf.rhea-db.org/21036']/rh:bidirectionalReaction and rh:directionalReaction""}, {""reference_id"": ""RHEA:45798"", ""source_assertion"": ""Rhea directly cross-references RHEA:45798 to MetaCyc:RXN-5901 in rdfs:seeAlso."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/45798']/rdfs:seeAlso[@rdf:resource='http://identifiers.org/biocyc/METACYC:RXN-5901']""}]"	"[{""id"": ""MetaCyc:PWY1-3"", ""source_sha256"": ""3469d020b1a4685466f2739fe280849df9578d2a20e798a95bed3e847de4f03d"", ""source_version"": ""22.5"", ""title"": ""MetaCyc polyhydroxybutanoate biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY1-3""}, {""id"": ""RHEA:21037"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 21037 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:45798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 45798 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY1-3_phb-edge-020_014297f833a6	RHEA:45798	pathwaymech:precedes	RHEA:15406	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY1-3|RHEA:15406|RHEA:45798		"[{""reference_id"": ""MetaCyc:PWY1-3"", ""source_assertion"": ""MetaCyc PWY1-3 declares RXN-5901 as a predecessor of RXN1-42."", ""source_locator"": ""Pathway/reaction-ordering[Reaction/@frameid='RXN1-42']/predecessor-reactions/Reaction[@frameid='RXN-5901']""}, {""reference_id"": ""RHEA:45798"", ""source_assertion"": ""Rhea directly cross-references RHEA:45798 to MetaCyc:RXN-5901 in rdfs:seeAlso."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/45798']/rdfs:seeAlso[@rdf:resource='http://identifiers.org/biocyc/METACYC:RXN-5901']""}, {""reference_id"": ""RHEA:15406"", ""source_assertion"": ""Rhea directly cross-references RHEA:15406 to MetaCyc:RXN1-42 in rdfs:seeAlso."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15406']/rdfs:seeAlso[@rdf:resource='http://identifiers.org/biocyc/METACYC:RXN1-42']""}]"	"[{""id"": ""MetaCyc:PWY1-3"", ""source_sha256"": ""3469d020b1a4685466f2739fe280849df9578d2a20e798a95bed3e847de4f03d"", ""source_version"": ""22.5"", ""title"": ""MetaCyc polyhydroxybutanoate biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY1-3""}, {""id"": ""RHEA:15406"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 15406 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:45798"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 45798 directed PHB biosynthetic reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-001_08b8e4896631	CHEBI:30616	pathwaymech:consumes	RHEA:27687	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27687		"[{""reference_id"": ""RHEA:27687"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:27687 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27687']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27687"", ""source_version"": ""139"", ""title"": ""Rhea GTP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/27687""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-002_86b18e9d6f69	CHEBI:58189	pathwaymech:consumes	RHEA:27687	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27687		"[{""reference_id"": ""RHEA:27687"", ""source_assertion"": ""Rhea lists CHEBI:58189 on the substrates side of RHEA:27687 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27687']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27687"", ""source_version"": ""139"", ""title"": ""Rhea GTP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/27687""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-003_92aa418f89e5	RHEA:27687	pathwaymech:produces	CHEBI:37565	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27687		"[{""reference_id"": ""RHEA:27687"", ""source_assertion"": ""Rhea lists CHEBI:37565 on the products side of RHEA:27687 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27687']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27687"", ""source_version"": ""139"", ""title"": ""Rhea GTP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/27687""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-004_ea2cf92b6658	RHEA:27687	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27687		"[{""reference_id"": ""RHEA:27687"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:27687 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27687']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27687"", ""source_version"": ""139"", ""title"": ""Rhea GTP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/27687""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-005_1edeb90c7d00	CHEBI:142410	pathwaymech:consumes	RHEA:33056	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33056		"[{""reference_id"": ""RHEA:33056"", ""source_assertion"": ""Rhea lists CHEBI:142410 on the substrates side of RHEA:33056 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33056']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:33056"", ""source_version"": ""139"", ""title"": ""Rhea GTP-forming pppGpp hydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/33056""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-006_374bf507695a	CHEBI:15377	pathwaymech:consumes	RHEA:33056	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33056		"[{""reference_id"": ""RHEA:33056"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:33056 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33056']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:33056"", ""source_version"": ""139"", ""title"": ""Rhea GTP-forming pppGpp hydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/33056""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-007_8bdb71233e0e	RHEA:33056	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33056		"[{""reference_id"": ""RHEA:33056"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:33056 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33056']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:33056"", ""source_version"": ""139"", ""title"": ""Rhea GTP-forming pppGpp hydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/33056""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-008_94a09c0262af	RHEA:33056	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33056		"[{""reference_id"": ""RHEA:33056"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:33056 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33056']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:33056"", ""source_version"": ""139"", ""title"": ""Rhea GTP-forming pppGpp hydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/33056""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-009_53cefedee236	RHEA:33056	pathwaymech:produces	CHEBI:37565	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33056		"[{""reference_id"": ""RHEA:33056"", ""source_assertion"": ""Rhea lists CHEBI:37565 on the products side of RHEA:33056 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/33056']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:33056"", ""source_version"": ""139"", ""title"": ""Rhea GTP-forming pppGpp hydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/33056""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-010_aece0662f05b	CHEBI:30616	pathwaymech:consumes	RHEA:28099	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28099		"[{""reference_id"": ""RHEA:28099"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:28099 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28099']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28099"", ""source_version"": ""139"", ""title"": ""Rhea ppGpp-forming GDP pyrophosphokinase direction"", ""url"": ""https://www.rhea-db.org/rhea/28099""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-011_e61af2218b57	CHEBI:58189	pathwaymech:consumes	RHEA:28099	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28099		"[{""reference_id"": ""RHEA:28099"", ""source_assertion"": ""Rhea lists CHEBI:58189 on the substrates side of RHEA:28099 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28099']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28099"", ""source_version"": ""139"", ""title"": ""Rhea ppGpp-forming GDP pyrophosphokinase direction"", ""url"": ""https://www.rhea-db.org/rhea/28099""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-012_974e64c0b83f	RHEA:28099	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28099		"[{""reference_id"": ""RHEA:28099"", ""source_assertion"": ""Rhea lists CHEBI:456215 on the products side of RHEA:28099 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28099']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28099"", ""source_version"": ""139"", ""title"": ""Rhea ppGpp-forming GDP pyrophosphokinase direction"", ""url"": ""https://www.rhea-db.org/rhea/28099""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-013_17bc091111b1	RHEA:28099	pathwaymech:produces	CHEBI:77828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28099		"[{""reference_id"": ""RHEA:28099"", ""source_assertion"": ""Rhea lists CHEBI:77828 on the products side of RHEA:28099 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28099']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28099"", ""source_version"": ""139"", ""title"": ""Rhea ppGpp-forming GDP pyrophosphokinase direction"", ""url"": ""https://www.rhea-db.org/rhea/28099""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-014_39b7eb864964	CHEBI:30616	pathwaymech:consumes	RHEA:22089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22089		"[{""reference_id"": ""RHEA:22089"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:22089 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22089']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22089"", ""source_version"": ""139"", ""title"": ""Rhea pppGpp-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22089""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-015_385cbe0c149c	CHEBI:37565	pathwaymech:consumes	RHEA:22089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22089		"[{""reference_id"": ""RHEA:22089"", ""source_assertion"": ""Rhea lists CHEBI:37565 on the substrates side of RHEA:22089 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22089']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22089"", ""source_version"": ""139"", ""title"": ""Rhea pppGpp-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22089""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-016_adf58e623798	RHEA:22089	pathwaymech:produces	CHEBI:142410	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22089		"[{""reference_id"": ""RHEA:22089"", ""source_assertion"": ""Rhea lists CHEBI:142410 on the products side of RHEA:22089 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22089']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22089"", ""source_version"": ""139"", ""title"": ""Rhea pppGpp-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22089""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-017_92ee0b962e3f	RHEA:22089	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22089		"[{""reference_id"": ""RHEA:22089"", ""source_assertion"": ""Rhea lists CHEBI:456215 on the products side of RHEA:22089 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22089']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:22089"", ""source_version"": ""139"", ""title"": ""Rhea pppGpp-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/22089""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-018_02470a81ecd2	CHEBI:15377	pathwaymech:consumes	RHEA:14254	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14254		"[{""reference_id"": ""RHEA:14254"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:14254 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14254']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14254"", ""source_version"": ""139"", ""title"": ""Rhea GDP-forming ppGpp hydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/14254""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-019_84005156c4e3	CHEBI:77828	pathwaymech:consumes	RHEA:14254	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14254		"[{""reference_id"": ""RHEA:14254"", ""source_assertion"": ""Rhea lists CHEBI:77828 on the substrates side of RHEA:14254 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14254']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14254"", ""source_version"": ""139"", ""title"": ""Rhea GDP-forming ppGpp hydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/14254""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-020_0c6167f5f00c	RHEA:14254	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14254		"[{""reference_id"": ""RHEA:14254"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:14254 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14254']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14254"", ""source_version"": ""139"", ""title"": ""Rhea GDP-forming ppGpp hydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/14254""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-021_97848e413b61	RHEA:14254	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14254		"[{""reference_id"": ""RHEA:14254"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:14254 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14254']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14254"", ""source_version"": ""139"", ""title"": ""Rhea GDP-forming ppGpp hydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/14254""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-022_9b5faeadef9c	RHEA:14254	pathwaymech:produces	CHEBI:58189	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14254		"[{""reference_id"": ""RHEA:14254"", ""source_assertion"": ""Rhea lists CHEBI:58189 on the products side of RHEA:14254 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/14254']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14254"", ""source_version"": ""139"", ""title"": ""Rhea GDP-forming ppGpp hydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/14254""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-023_20b15ff9d779	CHEBI:142410	pathwaymech:consumes	RHEA:13074	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13074		"[{""reference_id"": ""RHEA:13074"", ""source_assertion"": ""Rhea lists CHEBI:142410 on the substrates side of RHEA:13074 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13074']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13074"", ""source_version"": ""139"", ""title"": ""Rhea ppGpp-forming pppGpp hydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/13074""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-024_dce12caf1d7d	CHEBI:15377	pathwaymech:consumes	RHEA:13074	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13074		"[{""reference_id"": ""RHEA:13074"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:13074 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13074']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13074"", ""source_version"": ""139"", ""title"": ""Rhea ppGpp-forming pppGpp hydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/13074""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-025_a226a9a81731	RHEA:13074	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13074		"[{""reference_id"": ""RHEA:13074"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:13074 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13074']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13074"", ""source_version"": ""139"", ""title"": ""Rhea ppGpp-forming pppGpp hydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/13074""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-026_e18948cc6d1c	RHEA:13074	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13074		"[{""reference_id"": ""RHEA:13074"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:13074 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13074']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13074"", ""source_version"": ""139"", ""title"": ""Rhea ppGpp-forming pppGpp hydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/13074""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-027_4f0fc1decae8	RHEA:13074	pathwaymech:produces	CHEBI:77828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13074		"[{""reference_id"": ""RHEA:13074"", ""source_assertion"": ""Rhea lists CHEBI:77828 on the products side of RHEA:13074 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13074']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13074"", ""source_version"": ""139"", ""title"": ""Rhea ppGpp-forming pppGpp hydrolase direction"", ""url"": ""https://www.rhea-db.org/rhea/13074""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-028_1e1cf92108c5	EC:2.7.4.6	pathwaymech:catalyzes	RHEA:27687	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27686		"[{""reference_id"": ""RHEA:27686"", ""source_assertion"": ""Rhea associates EC:2.7.4.6 with the reaction family containing RHEA:27687."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:27686"", ""source_version"": ""139"", ""title"": ""Rhea GDP kinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/27686""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-029_95180c442c73	EC:3.1.7.2	pathwaymech:catalyzes	RHEA:33056	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:33055		"[{""reference_id"": ""RHEA:33055"", ""source_assertion"": ""Rhea associates EC:3.1.7.2 with the reaction family containing RHEA:33056."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:33055"", ""source_version"": ""139"", ""title"": ""Rhea guanosine 3'-diphosphate 5'-triphosphate hydrolase reaction"", ""url"": ""https://www.rhea-db.org/rhea/33055""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-030_bf65f7f5e837	EC:2.7.6.5	pathwaymech:catalyzes	RHEA:28099	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PPGPPMET-PWY		"[{""reference_id"": ""MetaCyc:PPGPPMET-PWY"", ""source_assertion"": ""The native pathway assigns EC:2.7.6.5 activity to the enzymatic step represented by RHEA:28099; this is a component step when the EC definition is an overall reaction."", ""source_locator"": ""Pathway/reaction-layout; Reaction/enzymatic-reaction and component-reaction relationships""}]"	"[{""id"": ""MetaCyc:PPGPPMET-PWY"", ""source_sha256"": ""5889d67922e973f3777b470f2d9ea185b6f7c16ce6b9f66d43c342dad33ab883"", ""source_version"": ""22.5"", ""title"": ""MetaCyc ppGpp metabolism pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PPGPPMET-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-031_32ca5cc16947	EC:2.7.6.5	pathwaymech:catalyzes	RHEA:22089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22088		"[{""reference_id"": ""RHEA:22088"", ""source_assertion"": ""Rhea associates EC:2.7.6.5 with the reaction family containing RHEA:22089."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:22088"", ""source_version"": ""139"", ""title"": ""Rhea GTP pyrophosphokinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/22088""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-032_4f59f4878543	EC:3.1.7.2	pathwaymech:catalyzes	RHEA:14254	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14253		"[{""reference_id"": ""RHEA:14253"", ""source_assertion"": ""Rhea associates EC:3.1.7.2 with the reaction family containing RHEA:14254."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:14253"", ""source_version"": ""139"", ""title"": ""Rhea ppGpp 3'-diphosphatase reaction"", ""url"": ""https://www.rhea-db.org/rhea/14253""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-033_8b5780ad2076	EC:3.6.1.40	pathwaymech:catalyzes	RHEA:13074	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13073		"[{""reference_id"": ""RHEA:13073"", ""source_assertion"": ""Rhea associates EC:3.6.1.40 with the reaction family containing RHEA:13074."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:13073"", ""source_version"": ""139"", ""title"": ""Rhea pppGpp 5'-phosphohydrolase reaction"", ""url"": ""https://www.rhea-db.org/rhea/13073""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-034_18f63ac1e76c	RHEA:13074	pathwaymech:precedes	RHEA:14254	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PPGPPMET-PWY		"[{""reference_id"": ""MetaCyc:PPGPPMET-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:13074 before RHEA:14254 in this pathway. Shared intermediate: CHEBI:77828."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PPGPPMET-PWY"", ""source_sha256"": ""5889d67922e973f3777b470f2d9ea185b6f7c16ce6b9f66d43c342dad33ab883"", ""source_version"": ""22.5"", ""title"": ""MetaCyc ppGpp metabolism pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PPGPPMET-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-035_f0c702d12c86	RHEA:14254	pathwaymech:precedes	RHEA:27687	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PPGPPMET-PWY		"[{""reference_id"": ""MetaCyc:PPGPPMET-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:14254 before RHEA:27687 in this pathway. Shared intermediate: CHEBI:58189."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PPGPPMET-PWY"", ""source_sha256"": ""5889d67922e973f3777b470f2d9ea185b6f7c16ce6b9f66d43c342dad33ab883"", ""source_version"": ""22.5"", ""title"": ""MetaCyc ppGpp metabolism pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PPGPPMET-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-036_d33b36a47f52	RHEA:14254	pathwaymech:precedes	RHEA:28099	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PPGPPMET-PWY		"[{""reference_id"": ""MetaCyc:PPGPPMET-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:14254 before RHEA:28099 in this pathway. Shared intermediate: CHEBI:58189."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PPGPPMET-PWY"", ""source_sha256"": ""5889d67922e973f3777b470f2d9ea185b6f7c16ce6b9f66d43c342dad33ab883"", ""source_version"": ""22.5"", ""title"": ""MetaCyc ppGpp metabolism pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PPGPPMET-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-037_2970942490bc	RHEA:22089	pathwaymech:precedes	RHEA:13074	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PPGPPMET-PWY		"[{""reference_id"": ""MetaCyc:PPGPPMET-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:22089 before RHEA:13074 in this pathway. Shared intermediate: CHEBI:142410."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PPGPPMET-PWY"", ""source_sha256"": ""5889d67922e973f3777b470f2d9ea185b6f7c16ce6b9f66d43c342dad33ab883"", ""source_version"": ""22.5"", ""title"": ""MetaCyc ppGpp metabolism pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PPGPPMET-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-038_3b7ceb759c06	RHEA:22089	pathwaymech:precedes	RHEA:33056	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PPGPPMET-PWY		"[{""reference_id"": ""MetaCyc:PPGPPMET-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:22089 before RHEA:33056 in this pathway. Shared intermediate: CHEBI:142410."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PPGPPMET-PWY"", ""source_sha256"": ""5889d67922e973f3777b470f2d9ea185b6f7c16ce6b9f66d43c342dad33ab883"", ""source_version"": ""22.5"", ""title"": ""MetaCyc ppGpp metabolism pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PPGPPMET-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-039_b16b60f2c616	RHEA:27687	pathwaymech:precedes	RHEA:22089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PPGPPMET-PWY		"[{""reference_id"": ""MetaCyc:PPGPPMET-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:27687 before RHEA:22089 in this pathway. Shared intermediate: CHEBI:37565."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PPGPPMET-PWY"", ""source_sha256"": ""5889d67922e973f3777b470f2d9ea185b6f7c16ce6b9f66d43c342dad33ab883"", ""source_version"": ""22.5"", ""title"": ""MetaCyc ppGpp metabolism pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PPGPPMET-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-040_b9d49e87d1d3	RHEA:28099	pathwaymech:precedes	RHEA:14254	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PPGPPMET-PWY		"[{""reference_id"": ""MetaCyc:PPGPPMET-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:28099 before RHEA:14254 in this pathway. Shared intermediate: CHEBI:77828."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PPGPPMET-PWY"", ""source_sha256"": ""5889d67922e973f3777b470f2d9ea185b6f7c16ce6b9f66d43c342dad33ab883"", ""source_version"": ""22.5"", ""title"": ""MetaCyc ppGpp metabolism pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PPGPPMET-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PPGPPMET-PWY_edge-041_64b04fc5675f	RHEA:33056	pathwaymech:precedes	RHEA:22089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PPGPPMET-PWY		"[{""reference_id"": ""MetaCyc:PPGPPMET-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:33056 before RHEA:22089 in this pathway. Shared intermediate: CHEBI:37565."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PPGPPMET-PWY"", ""source_sha256"": ""5889d67922e973f3777b470f2d9ea185b6f7c16ce6b9f66d43c342dad33ab883"", ""source_version"": ""22.5"", ""title"": ""MetaCyc ppGpp metabolism pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PPGPPMET-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-6019_pseudouridine-edge-001_25ee9afb5809	CHEBI:17802	pathwaymech:consumes	RHEA:22449	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22449		"[{""reference_id"": ""RHEA:22449"", ""source_assertion"": ""RHEA:22449 assigns CHEBI:17802 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/22449 rh:substrates; http://rdf.rhea-db.org/22448_L rh:contains1 http://rdf.rhea-db.org/Participant_22448_compound_3821; http://rdf.rhea-db.org/Participant_22448_compound_3821 rh:compound http://rdf.rhea-db.org/Compound_3821; rh:chebi""}]"	"[{""id"": ""RHEA:22449"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; named exact reaction and related triples selected by locators"", ""title"": ""Rhea directional reaction 22449"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6019_pseudouridine-edge-002_df2c7489d0a7	CHEBI:30616	pathwaymech:consumes	RHEA:22449	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22449		"[{""reference_id"": ""RHEA:22449"", ""source_assertion"": ""RHEA:22449 assigns CHEBI:30616 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/22449 rh:substrates; http://rdf.rhea-db.org/22448_L rh:contains1 http://rdf.rhea-db.org/Participant_22448_compound_6372; http://rdf.rhea-db.org/Participant_22448_compound_6372 rh:compound http://rdf.rhea-db.org/Compound_6372; rh:chebi""}]"	"[{""id"": ""RHEA:22449"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; named exact reaction and related triples selected by locators"", ""title"": ""Rhea directional reaction 22449"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6019_pseudouridine-edge-003_c1e86871bf68	RHEA:22449	pathwaymech:produces	CHEBI:58380	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22449		"[{""reference_id"": ""RHEA:22449"", ""source_assertion"": ""RHEA:22449 assigns CHEBI:58380 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/22449 rh:products; http://rdf.rhea-db.org/22448_R rh:contains1 http://rdf.rhea-db.org/Participant_22448_compound_1644; http://rdf.rhea-db.org/Participant_22448_compound_1644 rh:compound http://rdf.rhea-db.org/Compound_1644; rh:chebi""}]"	"[{""id"": ""RHEA:22449"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; named exact reaction and related triples selected by locators"", ""title"": ""Rhea directional reaction 22449"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6019_pseudouridine-edge-004_379e53833b1c	RHEA:22449	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22449		"[{""reference_id"": ""RHEA:22449"", ""source_assertion"": ""RHEA:22449 assigns CHEBI:456216 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/22449 rh:products; http://rdf.rhea-db.org/22448_R rh:contains1 http://rdf.rhea-db.org/Participant_22448_compound_2710; http://rdf.rhea-db.org/Participant_22448_compound_2710 rh:compound http://rdf.rhea-db.org/Compound_2710; rh:chebi""}]"	"[{""id"": ""RHEA:22449"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; named exact reaction and related triples selected by locators"", ""title"": ""Rhea directional reaction 22449"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6019_pseudouridine-edge-005_e14f55c2af9a	RHEA:22449	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22449		"[{""reference_id"": ""RHEA:22449"", ""source_assertion"": ""RHEA:22449 assigns CHEBI:15378 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/22449 rh:products; http://rdf.rhea-db.org/22448_R rh:contains1 http://rdf.rhea-db.org/Participant_22448_compound_3249; http://rdf.rhea-db.org/Participant_22448_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:22449"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; named exact reaction and related triples selected by locators"", ""title"": ""Rhea directional reaction 22449"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6019_pseudouridine-edge-006_e655a8d33658	CHEBI:58380	pathwaymech:consumes	RHEA:18339	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18339		"[{""reference_id"": ""RHEA:18339"", ""source_assertion"": ""RHEA:18339 assigns CHEBI:58380 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/18339 rh:substrates; http://rdf.rhea-db.org/18337_R rh:contains1 http://rdf.rhea-db.org/Participant_18337_compound_1644; http://rdf.rhea-db.org/Participant_18337_compound_1644 rh:compound http://rdf.rhea-db.org/Compound_1644; rh:chebi""}]"	"[{""id"": ""RHEA:18339"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; named exact reaction and related triples selected by locators"", ""title"": ""Rhea directional reaction 18339"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6019_pseudouridine-edge-007_1de8bcfee9fb	CHEBI:15377	pathwaymech:consumes	RHEA:18339	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18339		"[{""reference_id"": ""RHEA:18339"", ""source_assertion"": ""RHEA:18339 assigns CHEBI:15377 to its substrates, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/18339 rh:substrates; http://rdf.rhea-db.org/18337_R rh:contains1 http://rdf.rhea-db.org/Participant_18337_compound_1283; http://rdf.rhea-db.org/Participant_18337_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; rh:chebi""}]"	"[{""id"": ""RHEA:18339"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; named exact reaction and related triples selected by locators"", ""title"": ""Rhea directional reaction 18339"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6019_pseudouridine-edge-008_7b27a6186bbd	RHEA:18339	pathwaymech:produces	CHEBI:78346	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18339		"[{""reference_id"": ""RHEA:18339"", ""source_assertion"": ""RHEA:18339 assigns CHEBI:78346 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/18339 rh:products; http://rdf.rhea-db.org/18337_L rh:contains1 http://rdf.rhea-db.org/Participant_18337_compound_9495; http://rdf.rhea-db.org/Participant_18337_compound_9495 rh:compound http://rdf.rhea-db.org/Compound_9495; rh:chebi""}]"	"[{""id"": ""RHEA:18339"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; named exact reaction and related triples selected by locators"", ""title"": ""Rhea directional reaction 18339"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6019_pseudouridine-edge-009_14d1a52b778f	RHEA:18339	pathwaymech:produces	CHEBI:17568	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18339		"[{""reference_id"": ""RHEA:18339"", ""source_assertion"": ""RHEA:18339 assigns CHEBI:17568 to its products, coefficient 1 via rh:contains1."", ""source_locator"": ""http://rdf.rhea-db.org/18339 rh:products; http://rdf.rhea-db.org/18337_L rh:contains1 http://rdf.rhea-db.org/Participant_18337_compound_4063; http://rdf.rhea-db.org/Participant_18337_compound_4063 rh:compound http://rdf.rhea-db.org/Compound_4063; rh:chebi""}]"	"[{""id"": ""RHEA:18339"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; named exact reaction and related triples selected by locators"", ""title"": ""Rhea directional reaction 18339"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6019_pseudouridine-edge-010_51744fe4147c	UniProtKB:P30235	pathwaymech:enables	RHEA:22449	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:18591240|PMID:35783380|RHEA:22449|UniProtKB:P30235	This gene-product/activity assertion does not establish an independently sufficient monomer. The cited dimer experiments concern strain B/BL21; K-12 oligomeric state remains unestablished by these sources. Assay MgATP does not separately establish free-Mg cofactor binding.	"[{""reference_id"": ""UniProtKB:P30235"", ""source_assertion"": ""Reviewed K-12 PsuK annotates pseudouridine phosphorylation and RHEA:22448 with ECO:0000269 PMID:18591240. The original physiological study used UTI89; this edge retains the curated K-12 gene-product assignment."", ""source_locator"": ""/organism/taxonId; /comments/0; /comments/1/reaction""}, {""reference_id"": ""RHEA:22449"", ""source_assertion"": ""Master RHEA:22448 explicitly links directionalReaction RHEA:22449."", ""source_locator"": ""http://rdf.rhea-db.org/22448 rh:directionalReaction http://rdf.rhea-db.org/22449""}, {""quote"": ""specifically phosphorylates pseudouridine to pseudouridine 5'-phosphate"", ""reference_id"": ""PMID:18591240"", ""source_locator"": ""/resultList/result[id=\""18591240\""]/abstractText""}, {""reference_id"": ""PMID:35783380"", ""source_assertion"": ""The BL21-derived PsuK protein forms a homodimer by solution SEC and crystallography; the construct is A0A140N873, not the selected K-12 accession. Assays contain MgCl2 and KCl; the putative Mg sites were not modeled."", ""source_locator"": ""PMC9247573: Results/Dimeric Structure of EcPsuK; Materials and Methods/Protein Expression and Purification; Activity Assay; Discussion""}]"	"[{""id"": ""PMID:18591240"", ""source_sha256"": ""6c00509a7d51990543f07b857a3d9b68d3f83f7dd021434ab741c69d9ac89715"", ""source_version"": ""2008; indexed abstract in Europe PMC core response; body digest covers retained JSON, not inaccessible full article"", ""title"": ""Molecular identification of pseudouridine-metabolizing enzymes."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/18591240/""}, {""id"": ""PMID:35783380"", ""source_sha256"": ""4e3aa540e9310c71c6dbfa13261254cd1fa9c1708ac2e226d7eba87fc9e75ba1"", ""source_version"": ""2022; complete PMC9247573 JATS XML; retrieved 2026-10-11 UTC"", ""title"": ""Structure Characterization of Escherichia coli Pseudouridine Kinase PsuK."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9247573/fullTextXML""}, {""id"": ""RHEA:22449"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; named exact reaction and related triples selected by locators"", ""title"": ""Rhea directional reaction 22449"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P30235"", ""source_sha256"": ""a7c8ccd78e55cc458022bfa6d9add6c4647a29690712bd51dd107648fce5faaa"", ""source_version"": ""UniProt 2026_03; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed K-12 Pseudouridine kinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30235.json""}]"	""
pathwaymech:MetaCyc_PWY-6019_pseudouridine-edge-011_3c27f7bd8822	MetaCyc:CPLX0-8233	pathwaymech:catalyzes	RHEA:18339	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8233|PMID:23066817|RHEA:18339|UniProtKB:P33025	PsuG is reversible; selecting degradation does not make the reverse synthesis impossible. The 2012 kinetic assay favors the reverse reaction and must not be read as a measured forward physiological flux.	"[{""reference_id"": ""MetaCyc:CPLX0-8233"", ""source_assertion"": ""CPLX0-8233 catalyzes RXN0-5398 through ENZRXN0-6547; the pathway selects the cleavage direction."", ""source_locator"": ""Protein[@frameid=\""CPLX0-8233\""]/catalyzes/Enzymatic-Reaction[@frameid=\""ENZRXN0-6547\""]/reaction""}, {""reference_id"": ""UniProtKB:P33025"", ""source_assertion"": ""Reviewed K-12 PsuG annotates reversible PsiMP cleavage, physiological cleavage direction and RHEA:18337, citing experimental PMIDs 18591240/23066817 plus HAMAP MF_01876 inference."", ""source_locator"": ""/organism/taxonId; /comments/0; /comments/1/reaction""}, {""reference_id"": ""PMID:23066817"", ""source_assertion"": ""The study amplified yeiN from K12 DNA and characterized recombinant enzyme in BL21. Structures and covalent-adduct experiments support C-C bond cleavage; steady-state kinetic parameters were measured in the reverse synthetic direction."", ""source_locator"": ""PMC3526674 BioC passages offsets6100,6949,23258,24413,34501""}, {""reference_id"": ""RHEA:18339"", ""source_assertion"": ""Master RHEA:18337 explicitly links directionalReaction RHEA:18339, the right-to-left cleavage member."", ""source_locator"": ""http://rdf.rhea-db.org/18337 rh:directionalReaction http://rdf.rhea-db.org/18339""}]"	"[{""id"": ""MetaCyc:CPLX0-8233"", ""source_sha256"": ""5301e5c6d46a992965df5155185be0325b10a28e409b42ccf27c582bb628facf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""pseudouridine-5'-phosphate glycosidase trimer"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8233""}, {""id"": ""PMID:23066817"", ""source_sha256"": ""aefa88d2a4a9e3912cdf48af62c6e521462388134b75a730c6d93be1008dadfe"", ""source_version"": ""2012; complete primary article via PMC BioC XML; retrieved 2026-10-11 UTC"", ""title"": ""Pseudouridine monophosphate glycosidase: a new glycosidase mechanism."", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC3526674/unicode""}, {""id"": ""RHEA:18339"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; named exact reaction and related triples selected by locators"", ""title"": ""Rhea directional reaction 18339"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P33025"", ""source_sha256"": ""8515b173013f1419a1f66f02c8941611ef98f313482e9492713c79183101669b"", ""source_version"": ""UniProt 2026_03; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed K-12 Pseudouridine-5'-phosphate glycosidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33025.json""}]"	""
pathwaymech:MetaCyc_PWY-6019_pseudouridine-edge-012_2b40f5b6f0a4	UniProtKB:P33025	BFO:0000050	MetaCyc:CPLX0-8233	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8233|MetaCyc:EG12033-MONOMER|PMID:23066817|UniProtKB:P33025	Three copies form the native trimer. The monomer node is a subunit and is not independently assigned catalytic sufficiency.	"[{""reference_id"": ""MetaCyc:CPLX0-8233"", ""source_assertion"": ""The native complex has three EG12033-MONOMER components."", ""source_locator"": ""Protein[@frameid=\""CPLX0-8233\""]/component/Protein; component/coefficient""}, {""reference_id"": ""MetaCyc:EG12033-MONOMER"", ""source_assertion"": ""EG12033-MONOMER has explicit UNIPROT P33025 unification and MG1655 native taxonomy."", ""source_locator"": ""Protein[@frameid=\""EG12033-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]; species/Organism""}, {""reference_id"": ""UniProtKB:P33025"", ""source_assertion"": ""SUBUNIT specifies homotrimer with ECO:0000269 PMID:23066817 and HAMAP MF_01876."", ""source_locator"": ""/comments/5""}, {""quote"": ""ΨMP glycosidase is a homotrimer"", ""reference_id"": ""PMID:23066817"", ""source_locator"": ""PMC3526674 BioC passage offset17266""}]"	"[{""id"": ""MetaCyc:CPLX0-8233"", ""source_sha256"": ""5301e5c6d46a992965df5155185be0325b10a28e409b42ccf27c582bb628facf"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""pseudouridine-5'-phosphate glycosidase trimer"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8233""}, {""id"": ""MetaCyc:EG12033-MONOMER"", ""source_sha256"": ""7abaa29efdee617d4f8bbc3c45b08735d205f7744fcf63b334321a03f18aa692"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""PsuG subunit native cross-reference"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:EG12033-MONOMER""}, {""id"": ""PMID:23066817"", ""source_sha256"": ""aefa88d2a4a9e3912cdf48af62c6e521462388134b75a730c6d93be1008dadfe"", ""source_version"": ""2012; complete primary article via PMC BioC XML; retrieved 2026-10-11 UTC"", ""title"": ""Pseudouridine monophosphate glycosidase: a new glycosidase mechanism."", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC3526674/unicode""}, {""id"": ""UniProtKB:P33025"", ""source_sha256"": ""8515b173013f1419a1f66f02c8941611ef98f313482e9492713c79183101669b"", ""source_version"": ""UniProt 2026_03; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed K-12 Pseudouridine-5'-phosphate glycosidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33025.json""}]"	""
pathwaymech:MetaCyc_PWY-6019_pseudouridine-edge-013_900e6b08bf71	MetaCyc:CPLX0-8233	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:23066817|UniProtKB:P33025	Alternative metal-supported activity is retained; this does not assert simultaneous occupancy by all three metals or establish the dominant in vivo metal. Structural manganese occupancy is one per subunit.	"[{""reference_id"": ""UniProtKB:P33025"", ""source_assertion"": ""PsuG COFACTOR explicitly includes Mn(2+); the annotation states one manganese per subunit and allows Fe(2+) and Co(2+) alternatives, with experimental citations 18591240/23066817."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}, {""reference_id"": ""PMID:23066817"", ""source_assertion"": ""The hydrated Mn site has one Asp ligand and five water ligands; the paper reports highest activity with Fe(II), Co(II) and Mn(II), while Zn and, less strongly, Ni inhibit."", ""source_locator"": ""PMC3526674 BioC passages offsets18370,31636""}]"	"[{""id"": ""PMID:23066817"", ""source_sha256"": ""aefa88d2a4a9e3912cdf48af62c6e521462388134b75a730c6d93be1008dadfe"", ""source_version"": ""2012; complete primary article via PMC BioC XML; retrieved 2026-10-11 UTC"", ""title"": ""Pseudouridine monophosphate glycosidase: a new glycosidase mechanism."", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC3526674/unicode""}, {""id"": ""UniProtKB:P33025"", ""source_sha256"": ""8515b173013f1419a1f66f02c8941611ef98f313482e9492713c79183101669b"", ""source_version"": ""UniProt 2026_03; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed K-12 Pseudouridine-5'-phosphate glycosidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33025.json""}]"	""
pathwaymech:MetaCyc_PWY-6019_pseudouridine-edge-014_47dc9cdde8aa	MetaCyc:CPLX0-8233	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:23066817|UniProtKB:P33025	Alternative metal-supported activity is retained; this does not assert simultaneous occupancy by all three metals or establish the dominant in vivo metal. Structural manganese occupancy is one per subunit.	"[{""reference_id"": ""UniProtKB:P33025"", ""source_assertion"": ""PsuG COFACTOR explicitly includes Fe(2+); the annotation states one manganese per subunit and allows Fe(2+) and Co(2+) alternatives, with experimental citations 18591240/23066817."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}, {""reference_id"": ""PMID:23066817"", ""source_assertion"": ""The hydrated Mn site has one Asp ligand and five water ligands; the paper reports highest activity with Fe(II), Co(II) and Mn(II), while Zn and, less strongly, Ni inhibit."", ""source_locator"": ""PMC3526674 BioC passages offsets18370,31636""}]"	"[{""id"": ""PMID:23066817"", ""source_sha256"": ""aefa88d2a4a9e3912cdf48af62c6e521462388134b75a730c6d93be1008dadfe"", ""source_version"": ""2012; complete primary article via PMC BioC XML; retrieved 2026-10-11 UTC"", ""title"": ""Pseudouridine monophosphate glycosidase: a new glycosidase mechanism."", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC3526674/unicode""}, {""id"": ""UniProtKB:P33025"", ""source_sha256"": ""8515b173013f1419a1f66f02c8941611ef98f313482e9492713c79183101669b"", ""source_version"": ""UniProt 2026_03; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed K-12 Pseudouridine-5'-phosphate glycosidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33025.json""}]"	""
pathwaymech:MetaCyc_PWY-6019_pseudouridine-edge-015_283805b4b0d6	MetaCyc:CPLX0-8233	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:23066817|UniProtKB:P33025	Alternative metal-supported activity is retained; this does not assert simultaneous occupancy by all three metals or establish the dominant in vivo metal. Structural manganese occupancy is one per subunit.	"[{""reference_id"": ""UniProtKB:P33025"", ""source_assertion"": ""PsuG COFACTOR explicitly includes Co(2+); the annotation states one manganese per subunit and allows Fe(2+) and Co(2+) alternatives, with experimental citations 18591240/23066817."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}, {""reference_id"": ""PMID:23066817"", ""source_assertion"": ""The hydrated Mn site has one Asp ligand and five water ligands; the paper reports highest activity with Fe(II), Co(II) and Mn(II), while Zn and, less strongly, Ni inhibit."", ""source_locator"": ""PMC3526674 BioC passages offsets18370,31636""}]"	"[{""id"": ""PMID:23066817"", ""source_sha256"": ""aefa88d2a4a9e3912cdf48af62c6e521462388134b75a730c6d93be1008dadfe"", ""source_version"": ""2012; complete primary article via PMC BioC XML; retrieved 2026-10-11 UTC"", ""title"": ""Pseudouridine monophosphate glycosidase: a new glycosidase mechanism."", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC3526674/unicode""}, {""id"": ""UniProtKB:P33025"", ""source_sha256"": ""8515b173013f1419a1f66f02c8941611ef98f313482e9492713c79183101669b"", ""source_version"": ""UniProt 2026_03; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed K-12 Pseudouridine-5'-phosphate glycosidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33025.json""}]"	""
pathwaymech:MetaCyc_PWY-6019_pseudouridine-edge-016_db1793b31e1b	RHEA:22449	BFO:0000050	MetaCyc:PWY-6019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PSEUDOURIDINE-KINASE-RXN|MetaCyc:PWY-6019		"[{""reference_id"": ""MetaCyc:PWY-6019"", ""source_assertion"": ""PWY-6019 explicitly lists PSEUDOURIDINE-KINASE-RXN; reaction-layout selects L2R phosphorylation."", ""source_locator"": ""Pathway[@frameid=\""PWY-6019\""]/reaction-list; reaction-layout[Reaction/@frameid=\""PSEUDOURIDINE-KINASE-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:PSEUDOURIDINE-KINASE-RXN"", ""source_assertion"": ""PSEUDOURIDINE-KINASE-RXN has explicit RHEA 22449 unification cross-reference."", ""source_locator"": ""Reaction[@frameid=\""PSEUDOURIDINE-KINASE-RXN\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid; dblink-relationship""}]"	"[{""id"": ""MetaCyc:PSEUDOURIDINE-KINASE-RXN"", ""source_sha256"": ""fa0d95c4aee8ee9b7d527b44b4c597ea737e9cf15bcb0d4aa3f147f6932a064f"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""pseudouridine kinase reaction"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PSEUDOURIDINE-KINASE-RXN""}, {""id"": ""MetaCyc:PWY-6019"", ""source_sha256"": ""046d3d9379d13ca3e2fd721ea3e30e665fc74b2ed9647617eda77ad3856b261b"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""pseudouridine degradation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6019""}]"	""
pathwaymech:MetaCyc_PWY-6019_pseudouridine-edge-017_484d1d239dbc	RHEA:18339	BFO:0000050	MetaCyc:PWY-6019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6019|MetaCyc:RXN0-5398|RHEA:18339		"[{""reference_id"": ""MetaCyc:PWY-6019"", ""source_assertion"": ""PWY-6019 explicitly lists RXN0-5398; reaction-layout selects R2L cleavage."", ""source_locator"": ""Pathway[@frameid=\""PWY-6019\""]/reaction-list; reaction-layout[Reaction/@frameid=\""RXN0-5398\""]/direction""}, {""reference_id"": ""MetaCyc:RXN0-5398"", ""source_assertion"": ""RXN0-5398 has explicit RHEA 18340 unification cross-reference."", ""source_locator"": ""Reaction[@frameid=\""RXN0-5398\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid; dblink-relationship""}, {""reference_id"": ""RHEA:18339"", ""source_assertion"": ""Master RHEA:18337 links bidirectionalReaction RHEA:18340 and directionalReaction RHEA:18339; the latter is the selected cleavage variant."", ""source_locator"": ""http://rdf.rhea-db.org/18337 rh:bidirectionalReaction http://rdf.rhea-db.org/18340; rh:directionalReaction http://rdf.rhea-db.org/18339""}]"	"[{""id"": ""MetaCyc:PWY-6019"", ""source_sha256"": ""046d3d9379d13ca3e2fd721ea3e30e665fc74b2ed9647617eda77ad3856b261b"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""pseudouridine degradation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6019""}, {""id"": ""MetaCyc:RXN0-5398"", ""source_sha256"": ""2302af84f70259ddfaf8ef7752b686f1ed14b59b629181a8ec0e20bfa8b1366c"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""pseudouridine-5-phosphate glycosidase reversible reaction"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5398""}, {""id"": ""RHEA:18339"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; named exact reaction and related triples selected by locators"", ""title"": ""Rhea directional reaction 18339"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6019_pseudouridine-edge-018_4ff669dcf064	RHEA:22449	RO:0002413	RHEA:18339	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6019|PMID:18591240|RHEA:18339|RHEA:22449	The shared PsiMP is chemically identical across the two selected Rhea sides. ATP phosphorylation precedes reversible glycosidic-bond cleavage; downstream uracil utilization is not appended.	"[{""reference_id"": ""MetaCyc:PWY-6019"", ""source_assertion"": ""RXN0-5398 has PSEUDOURIDINE-KINASE-RXN as its explicit predecessor; the two reaction-layouts share PSEUDOURIDINE-5-P."", ""source_locator"": ""Pathway[@frameid=\""PWY-6019\""]/reaction-ordering; reaction-layout""}, {""reference_id"": ""RHEA:22449"", ""source_assertion"": ""RHEA:22449 produces CHEBI:58380, the substrate of the selected PsuG cleavage reaction."", ""source_locator"": ""http://rdf.rhea-db.org/22449 rh:products; http://rdf.rhea-db.org/22448_R rh:contains1""}, {""reference_id"": ""RHEA:18339"", ""source_assertion"": ""RHEA:18339 consumes CHEBI:58380 and water, producing uracil and D-ribofuranose 5-phosphate."", ""source_locator"": ""http://rdf.rhea-db.org/18339 rh:substrates; rh:products""}, {""reference_id"": ""PMID:18591240"", ""source_assertion"": ""The indexed primary abstract describes both sequential enzymes and reports failure of yeiC(-) UTI89 mutants to metabolize pseudouridine. This is direct UTI89 physiology, not a K-12 whole-cell flux measurement."", ""source_locator"": ""/resultList/result[id=\""18591240\""]/abstractText""}]"	"[{""id"": ""MetaCyc:PWY-6019"", ""source_sha256"": ""046d3d9379d13ca3e2fd721ea3e30e665fc74b2ed9647617eda77ad3856b261b"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""pseudouridine degradation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6019""}, {""id"": ""PMID:18591240"", ""source_sha256"": ""6c00509a7d51990543f07b857a3d9b68d3f83f7dd021434ab741c69d9ac89715"", ""source_version"": ""2008; indexed abstract in Europe PMC core response; body digest covers retained JSON, not inaccessible full article"", ""title"": ""Molecular identification of pseudouridine-metabolizing enzymes."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/18591240/""}, {""id"": ""RHEA:18339"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; named exact reaction and related triples selected by locators"", ""title"": ""Rhea directional reaction 18339"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:22449"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed RDF; named exact reaction and related triples selected by locators"", ""title"": ""Rhea directional reaction 22449"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-001_cd58ab52992d	CHEBI:17256	pathwaymech:consumes	RHEA:28191	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28191		"[{""reference_id"": ""RHEA:28191"", ""source_assertion"": ""Rhea RHEA:28191 assigns CHEBI:17256 to substrates with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28191']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28190_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28190_compound_1711']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28191"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 28191"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-002_895ca7627182	CHEBI:15377	pathwaymech:consumes	RHEA:28191	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28191		"[{""reference_id"": ""RHEA:28191"", ""source_assertion"": ""Rhea RHEA:28191 assigns CHEBI:15377 to substrates with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28191']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28190_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28190_compound_1283']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28191"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 28191"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-003_91ad5613425f	CHEBI:15378	pathwaymech:consumes	RHEA:28191	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28191		"[{""reference_id"": ""RHEA:28191"", ""source_assertion"": ""Rhea RHEA:28191 assigns CHEBI:15378 to substrates with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28191']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28190_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28190_compound_3249']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28191"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 28191"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-004_edffdae8a900	RHEA:28191	pathwaymech:produces	CHEBI:28997	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28191		"[{""reference_id"": ""RHEA:28191"", ""source_assertion"": ""Rhea RHEA:28191 assigns CHEBI:28997 to products with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28191']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28190_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28190_compound_6258']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28191"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 28191"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-005_9054eace82d5	RHEA:28191	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28191		"[{""reference_id"": ""RHEA:28191"", ""source_assertion"": ""Rhea RHEA:28191 assigns CHEBI:28938 to products with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28191']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28190_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28190_compound_1012']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28191"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 28191"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-006_22346ee1647e	CHEBI:17256	pathwaymech:consumes	RHEA:27743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27743		"[{""reference_id"": ""RHEA:27743"", ""source_assertion"": ""Rhea RHEA:27743 assigns CHEBI:17256 to substrates with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27743']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27742_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27742_compound_1711']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27743"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27743"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-007_59ca49e986d3	CHEBI:43474	pathwaymech:consumes	RHEA:27743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27743		"[{""reference_id"": ""RHEA:27743"", ""source_assertion"": ""Rhea RHEA:27743 assigns CHEBI:43474 to substrates with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27743']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27742_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27742_compound_5518']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27743"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27743"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-008_7d64f7c5b6d4	RHEA:27743	pathwaymech:produces	CHEBI:57259	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27743		"[{""reference_id"": ""RHEA:27743"", ""source_assertion"": ""Rhea RHEA:27743 assigns CHEBI:57259 to products with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27743']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27742_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27742_compound_3098']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27743"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27743"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-009_b4f7ddac03ad	RHEA:27743	pathwaymech:produces	CHEBI:16708	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27743		"[{""reference_id"": ""RHEA:27743"", ""source_assertion"": ""Rhea RHEA:27743 assigns CHEBI:16708 to products with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27743']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27742_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27742_compound_4174']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27743"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27743"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-010_5e380772297d	CHEBI:28997	pathwaymech:consumes	RHEA:27751	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27751		"[{""reference_id"": ""RHEA:27751"", ""source_assertion"": ""Rhea RHEA:27751 assigns CHEBI:28997 to substrates with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27751']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27750_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27750_compound_6258']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27751"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27751"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-011_cc5475092f14	CHEBI:43474	pathwaymech:consumes	RHEA:27751	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27751		"[{""reference_id"": ""RHEA:27751"", ""source_assertion"": ""Rhea RHEA:27751 assigns CHEBI:43474 to substrates with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27751']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27750_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27750_compound_5518']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27751"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27751"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-012_bc9e47279301	RHEA:27751	pathwaymech:produces	CHEBI:57259	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27751		"[{""reference_id"": ""RHEA:27751"", ""source_assertion"": ""Rhea RHEA:27751 assigns CHEBI:57259 to products with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27751']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27750_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27750_compound_3098']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27751"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27751"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-013_17c3786835a2	RHEA:27751	pathwaymech:produces	CHEBI:17368	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27751		"[{""reference_id"": ""RHEA:27751"", ""source_assertion"": ""Rhea RHEA:27751 assigns CHEBI:17368 to products with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27751']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27750_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27750_compound_3881']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27751"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27751"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-014_cffbb1b4df0e	CHEBI:17172	pathwaymech:consumes	RHEA:27739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27739		"[{""reference_id"": ""RHEA:27739"", ""source_assertion"": ""Rhea RHEA:27739 assigns CHEBI:17172 to substrates with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27739']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27738_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27738_compound_3664']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27739"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27739"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-015_9921e703f1c5	CHEBI:43474	pathwaymech:consumes	RHEA:27739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27739		"[{""reference_id"": ""RHEA:27739"", ""source_assertion"": ""Rhea RHEA:27739 assigns CHEBI:43474 to substrates with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27739']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27738_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27738_compound_5518']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27739"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27739"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-016_9006994ae545	RHEA:27739	pathwaymech:produces	CHEBI:57259	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27739		"[{""reference_id"": ""RHEA:27739"", ""source_assertion"": ""Rhea RHEA:27739 assigns CHEBI:57259 to products with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27739']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27738_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27738_compound_3098']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27739"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27739"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-017_4d7188dbd106	RHEA:27739	pathwaymech:produces	CHEBI:16235	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27739		"[{""reference_id"": ""RHEA:27739"", ""source_assertion"": ""Rhea RHEA:27739 assigns CHEBI:16235 to products with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27739']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27738_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27738_compound_2523']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27739"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27739"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-018_385d390e9e9e	CHEBI:57259	pathwaymech:consumes	RHEA:27659	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27659		"[{""reference_id"": ""RHEA:27659"", ""source_assertion"": ""Rhea RHEA:27659 assigns CHEBI:57259 to substrates with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27659']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27658_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27658_compound_3098']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27659"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27659"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-019_c02611fef951	RHEA:27659	pathwaymech:produces	CHEBI:62877	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27659		"[{""reference_id"": ""RHEA:27659"", ""source_assertion"": ""Rhea RHEA:27659 assigns CHEBI:62877 to products with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27659']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27658_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27658_compound_14166']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27659"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27659"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-020_fc414bdd6a83	CHEBI:62877	pathwaymech:consumes	RHEA:12822	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12822		"[{""reference_id"": ""RHEA:12822"", ""source_assertion"": ""Rhea RHEA:12822 assigns CHEBI:62877 to substrates with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12822']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/12821_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_12821_compound_14166']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:12822"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 12822"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-021_2b0ecc2bafa7	RHEA:12822	pathwaymech:produces	CHEBI:59776	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12822		"[{""reference_id"": ""RHEA:12822"", ""source_assertion"": ""Rhea RHEA:12822 assigns CHEBI:59776 to products with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12822']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/12821_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_12821_compound_6062']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:12822"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 12822"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-022_7030e3429bb7	RHEA:12822	pathwaymech:produces	CHEBI:15343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12822		"[{""reference_id"": ""RHEA:12822"", ""source_assertion"": ""Rhea RHEA:12822 assigns CHEBI:15343 to products with coefficient 1; the linked compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12822']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/12821_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_12821_compound_3952']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:12822"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 12822"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-023_9213c506f972	UniProtKB:P22333	pathwaymech:enables	RHEA:28191	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ADDALT-ENZRXN|MetaCyc:ADENODEAMIN-MONOMER|UniProtKB:P22333	Functional Add role; no inference that an isolated monomer is sufficient. Exact activity is attributed to the inspected curated sources; the cited 1978 full text was inaccessible.	"[{""reference_id"": ""UniProtKB:P22333"", ""source_assertion"": ""Reviewed Add catalytic-activity comment 2 assigns deoxyadenosine deamination to RHEA:28190 and physiological left-to-right RHEA:28191, with experimental attribution to PMID:357905 alongside HAMAP inference."", ""source_locator"": ""comments[2].reaction; comments[2].physiologicalReactions; comments[2].reaction.evidences""}, {""reference_id"": ""MetaCyc:ADDALT-ENZRXN"", ""source_assertion"": ""ADDALT-ENZRXN assigns ADDALT-RXN to ADENODEAMIN-MONOMER, marks it physiologically relevant and cites purified-native-protein assay evidence from PMID:357905."", ""source_locator"": ""Enzymatic-Reaction[@frameid=\""ADDALT-ENZRXN\""]/reaction, enzyme, physiologically-relevant, evidence""}, {""reference_id"": ""MetaCyc:ADENODEAMIN-MONOMER"", ""source_assertion"": ""The native Add entity explicitly cross-references UniProt P22333 and MG1655 TAX-511145; it distinguishes E. coli K-12 enzyme data from the murine monomeric zinc-enzyme comparison."", ""source_locator"": ""Protein[@frameid=\""ADENODEAMIN-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""], species, comment""}]"	"[{""id"": ""MetaCyc:ADDALT-ENZRXN"", ""source_sha256"": ""063bdf468d26aa2d59583fb900951c84ce0ce241d870ee27034a2fa432269e57"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native ADDALT-ENZRXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADDALT-ENZRXN""}, {""id"": ""MetaCyc:ADENODEAMIN-MONOMER"", ""source_sha256"": ""cd205f5ac0648b466801dbb087db3a5e129ec35d19e5482162ac564339020f39"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native ADENODEAMIN-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADENODEAMIN-MONOMER""}, {""id"": ""UniProtKB:P22333"", ""source_sha256"": ""23e32e2f4a9fc0b04d71ef7ccef5441c01b1b100951453b1f47d623fe4782181"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P22333"", ""url"": ""https://rest.uniprot.org/uniprotkb/P22333.json""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-024_9892aa0b6f5d	MetaCyc:DEOD-CPLX	pathwaymech:catalyzes	RHEA:27743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOD-CPLX|UniProtKB:P0ABP8	The physiologically relevant degradation direction is selected for reversible phosphorolysis; the catalyst is the DeoD hexamer.	"[{""reference_id"": ""UniProtKB:P0ABP8"", ""source_assertion"": ""Reviewed DeoD catalytic-activity comment 6 assigns the exact deoxyribonucleoside phosphorolysis to RHEA:27742, citing experimental PMID:235429; comment 10 identifies the homohexamer."", ""source_locator"": ""comments[6].reaction; comments[6].reaction.evidences; comments[10]""}, {""reference_id"": ""MetaCyc:DEOD-CPLX"", ""source_assertion"": ""The native purine nucleoside phosphorylase complex contains six DEOD-MONOMER subunits and catalyzes DEOXYADENPHOSPHOR-RXN."", ""source_locator"": ""Protein[@frameid=\""DEOD-CPLX\""]/component; catalyzes/Enzymatic-Reaction/reaction""}]"	"[{""id"": ""MetaCyc:DEOD-CPLX"", ""source_sha256"": ""f362dcc29babaf5d23e730a329a7c436a0944d811a36ad1adb8ee8569e7962e5"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOD-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOD-CPLX""}, {""id"": ""UniProtKB:P0ABP8"", ""source_sha256"": ""261a1c1e34fcc0af42d3a3b4a16c27a01ecba13eee2437d3f4d8c51e422eed02"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0ABP8"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABP8.json""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-025_c63364ae6458	MetaCyc:DEOD-CPLX	pathwaymech:catalyzes	RHEA:27751	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOD-CPLX|UniProtKB:P0ABP8	The physiologically relevant degradation direction is selected for reversible phosphorolysis; the catalyst is the DeoD hexamer.	"[{""reference_id"": ""UniProtKB:P0ABP8"", ""source_assertion"": ""Reviewed DeoD catalytic-activity comment 8 assigns the exact deoxyribonucleoside phosphorolysis to RHEA:27750, citing experimental PMID:235429; comment 10 identifies the homohexamer."", ""source_locator"": ""comments[8].reaction; comments[8].reaction.evidences; comments[10]""}, {""reference_id"": ""MetaCyc:DEOD-CPLX"", ""source_assertion"": ""The native purine nucleoside phosphorylase complex contains six DEOD-MONOMER subunits and catalyzes DEOXYINOPHOSPHOR-RXN."", ""source_locator"": ""Protein[@frameid=\""DEOD-CPLX\""]/component; catalyzes/Enzymatic-Reaction/reaction""}]"	"[{""id"": ""MetaCyc:DEOD-CPLX"", ""source_sha256"": ""f362dcc29babaf5d23e730a329a7c436a0944d811a36ad1adb8ee8569e7962e5"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOD-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOD-CPLX""}, {""id"": ""UniProtKB:P0ABP8"", ""source_sha256"": ""261a1c1e34fcc0af42d3a3b4a16c27a01ecba13eee2437d3f4d8c51e422eed02"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0ABP8"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABP8.json""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-026_d59ebd17f1d8	MetaCyc:DEOD-CPLX	pathwaymech:catalyzes	RHEA:27739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOD-CPLX|UniProtKB:P0ABP8	The physiologically relevant degradation direction is selected for reversible phosphorolysis; the catalyst is the DeoD hexamer.	"[{""reference_id"": ""UniProtKB:P0ABP8"", ""source_assertion"": ""Reviewed DeoD catalytic-activity comment 7 assigns the exact deoxyribonucleoside phosphorolysis to RHEA:27738, citing experimental PMID:235429; comment 10 identifies the homohexamer."", ""source_locator"": ""comments[7].reaction; comments[7].reaction.evidences; comments[10]""}, {""reference_id"": ""MetaCyc:DEOD-CPLX"", ""source_assertion"": ""The native purine nucleoside phosphorylase complex contains six DEOD-MONOMER subunits and catalyzes DEOXYGUANPHOSPHOR-RXN."", ""source_locator"": ""Protein[@frameid=\""DEOD-CPLX\""]/component; catalyzes/Enzymatic-Reaction/reaction""}]"	"[{""id"": ""MetaCyc:DEOD-CPLX"", ""source_sha256"": ""f362dcc29babaf5d23e730a329a7c436a0944d811a36ad1adb8ee8569e7962e5"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOD-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOD-CPLX""}, {""id"": ""UniProtKB:P0ABP8"", ""source_sha256"": ""261a1c1e34fcc0af42d3a3b4a16c27a01ecba13eee2437d3f4d8c51e422eed02"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0ABP8"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABP8.json""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-027_c21e6ecb8ce0	UniProtKB:P0A6K6	pathwaymech:catalyzes	RHEA:27659	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PPENTOMUT-MONOMER|PMID:1089430|UniProtKB:P0A6K6	Monomeric enzyme supported by the inspected physical-characterization abstract; C1-to-C5 degradation direction selected from the reversible reaction.	"[{""reference_id"": ""UniProtKB:P0A6K6"", ""source_assertion"": ""Reviewed DeoB catalytic-activity comment 1 assigns the exact deoxyribose 1-phosphate to 5-phosphate interconversion to RHEA:27658, citing PMID:1089430 and PMID:4992818."", ""source_locator"": ""comments[1].reaction; comments[1].reaction.evidences""}, {""reference_id"": ""PMID:1089430"", ""source_assertion"": ""The inspected primary abstract reports that all four purified phosphodeoxyribomutase forms consist of a single polypeptide chain, with molecular weight about 45,000, and have different cobalt-binding properties."", ""source_locator"": ""resultList.result[0].abstractText""}, {""reference_id"": ""MetaCyc:PPENTOMUT-MONOMER"", ""source_assertion"": ""PPENTOMUT-MONOMER explicitly cross-references UniProt P0A6K6, is assigned to MG1655 and catalyzes the deoxyribose phosphomutase reaction."", ""source_locator"": ""Protein[@frameid=\""PPENTOMUT-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""], species, catalyzes""}]"	"[{""id"": ""MetaCyc:PPENTOMUT-MONOMER"", ""source_sha256"": ""84c86e1b8614d1f6258f966e941c49d761907e4ce4d25f8e812e6cb0e8cfc6d6"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native PPENTOMUT-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PPENTOMUT-MONOMER""}, {""id"": ""PMID:1089430"", ""source_sha256"": ""b43ff5def2d79a3a67e05538ff51ae632c8f72fa957138e597467294d00c84e2"", ""source_version"": ""Primary indexed abstract inspected; no full-text claim"", ""title"": ""Multiple forms of phosphodeoxyribomutase from Escherichia coli. Physical and chemical characterization."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1089430%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P0A6K6"", ""source_sha256"": ""832643bbf42bfcb2ef2e5598e24ff7f18f224bde94291d56a8d5a61bed4b3d66"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0A6K6"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6K6.json""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-028_a77bc58dc1b6	UniProtKB:P0A6L0	pathwaymech:enables	RHEA:12822	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOXYRIBOSE-P-ALD-MONOMER|PMID:6749498|PMID:7675789|UniProtKB:P0A6L0	Functional DeoC role retains the documented monomer/dimer alternatives; no invented physical assembly or universal monomer-sufficiency claim. Degradation cleavage is selected from reversible aldol chemistry.	"[{""reference_id"": ""UniProtKB:P0A6L0"", ""source_assertion"": ""Reviewed DeoC assigns deoxyribose 5-phosphate cleavage to RHEA:12821, with experimental references, and explicitly annotates both monomer and homodimer states."", ""source_locator"": ""comments[1].reaction; comments[4]""}, {""reference_id"": ""PMID:7675789"", ""source_assertion"": ""The primary abstract identifies E. coli class I DERA and its reversible cleavage of deoxyribose 5-phosphate into acetaldehyde and glyceraldehyde 3-phosphate."", ""source_locator"": ""resultList.result[0].abstractText""}, {""reference_id"": ""PMID:6749498"", ""source_assertion"": ""The inspected E. coli K-12 primary abstract reports that purified DeoC may exist in both monomeric and dimeric forms."", ""source_locator"": ""resultList.result[0].abstractText""}, {""reference_id"": ""MetaCyc:DEOXYRIBOSE-P-ALD-MONOMER"", ""source_assertion"": ""The native MG1655 DeoC entity cross-references P0A6L0; its comment reports monomer in Tris/HCl with EDTA and dimer in phosphate buffer, citing PMID:6749498."", ""source_locator"": ""Protein[@frameid=\""DEOXYRIBOSE-P-ALD-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""], species, comment""}]"	"[{""id"": ""MetaCyc:DEOXYRIBOSE-P-ALD-MONOMER"", ""source_sha256"": ""8f9f749c26add22c93ac663ead671d74591d97f8fbfc47a0b3886e2eb1b4c848"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOXYRIBOSE-P-ALD-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOXYRIBOSE-P-ALD-MONOMER""}, {""id"": ""PMID:6749498"", ""source_sha256"": ""62d1dc57a84eb2477f4bef142fb3d8f84681b7e628439c2838294a3d35d12f89"", ""source_version"": ""Primary indexed abstract inspected; no full-text claim"", ""title"": ""The primary structure of Escherichia coli K12 2-deoxyribose 5-phosphate aldolase. Nucleotide sequence of the deoC gene and the amino acid sequence of the enzyme."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6749498%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""PMID:7675789"", ""source_sha256"": ""f95a349302cf3e77b3e883f012cfa00eb0b898c39b87a01280fc0f0afa6c3722"", ""source_version"": ""Primary indexed abstract inspected; no full-text claim"", ""title"": ""Crystallization and preliminary crystallographic data for class I deoxyribose-5-phosphate aldolase from Escherichia coli: an application of reverse screening."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7675789%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P0A6L0"", ""source_sha256"": ""01150821cd4ffac2f7a86659cd71e2304bb63dc76c118e7ae3716d8812b1f76c"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0A6L0"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6L0.json""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-029_74229540786c	UniProtKB:P0ABP8	BFO:0000050	MetaCyc:DEOD-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOD-CPLX|MetaCyc:DEOD-MONOMER|PMID:235429|PMID:30337572|PathBank:SMP0002089	Six DeoD copies per native complex. The PathBank and MetaCyc assembly descriptions corroborate composition; no physical-instance sameAs mapping is asserted.	"[{""reference_id"": ""MetaCyc:DEOD-CPLX"", ""source_assertion"": ""The native DEOD-CPLX component slot specifies six copies of DEOD-MONOMER."", ""source_locator"": ""Protein[@frameid=\""DEOD-CPLX\""]/component""}, {""reference_id"": ""MetaCyc:DEOD-MONOMER"", ""source_assertion"": ""DEOD-MONOMER explicitly cross-references UniProt P0ABP8 and is a component of DEOD-CPLX."", ""source_locator"": ""Protein[@frameid=\""DEOD-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""], component-of""}, {""reference_id"": ""PathBank:SMP0002089"", ""source_assertion"": ""Native ProteinComplex/4056 has six copies of Protein/6182; its protein reference identifies P0ABP8. This independently supports the same six-subunit composition."", ""source_locator"": ""bp:Complex[@rdf:ID=\""ProteinComplex/4056\""]/bp:componentStoichiometry; bp:Stoichiometry[@rdf:ID=\""Protein/6182/Stoichiometry/6.0\""]; bp:ProteinReference[@rdf:ID=\""ProteinReference/6182\""]/bp:xref""}, {""reference_id"": ""PMID:235429"", ""source_assertion"": ""The inspected primary abstract supports six identical subunits; association experiments suggest that only the hexameric form is active."", ""source_locator"": ""resultList.result[0].abstractText""}, {""reference_id"": ""PMID:30337572"", ""source_assertion"": ""The primary full text reports six identical chains arranged as a trimer of dimers and explains that the hexameric architecture stabilizes catalytically competent dimers."", ""source_locator"": ""body; Results and Discussion, crystal structures paragraph beginning \""All PNP structures\""; Conclusions""}]"	"[{""id"": ""MetaCyc:DEOD-CPLX"", ""source_sha256"": ""f362dcc29babaf5d23e730a329a7c436a0944d811a36ad1adb8ee8569e7962e5"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOD-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOD-CPLX""}, {""id"": ""MetaCyc:DEOD-MONOMER"", ""source_sha256"": ""99f6dcc78816a3a58aab669c0cdaa9a886a0c854dfa8076cbd9a03aa31766893"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOD-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOD-MONOMER""}, {""id"": ""PMID:235429"", ""source_sha256"": ""27b6d685708a8029c74c2b075ce547478d088766ce3af6011bbd22db57458432"", ""source_version"": ""Primary indexed abstract inspected; no full-text claim"", ""title"": ""Purine nucleoside phosphorylase from Escherichia coli and Salmonella typhimurium. Purification and some properties."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:235429%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""PMID:30337572"", ""source_sha256"": ""0c51eed472206bdb260953635e23b7354cf89098eb6abc75e21c6c0bc8e1fd63"", ""source_version"": ""2018 primary full text; PMC6193948 XML"", ""title"": ""Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6193948/fullTextXML""}, {""id"": ""PathBank:SMP0002089"", ""source_sha256"": ""c515d4778a7c92d66060ceeffac95c89149cc5400e388e1110fc2cd95fc040a6"", ""source_version"": ""Native BioPAX PW002077.owl from primary archive; SHA256 covers uncompressed member bytes"", ""title"": ""PathBank native purine deoxyribonucleosides degradation"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-030_cfa3c393be10	UniProtKB:P22333	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P22333	Inferred zinc cofactor annotation; the mammalian structural comparison is not transferred as E. coli experimental proof.	"[{""reference_id"": ""UniProtKB:P22333"", ""source_assertion"": ""Reviewed Add annotates Zn(2+) and one zinc ion per subunit using ECO:0000255 HAMAP-Rule MF_00540; this is sequence-based inference, not a directly inspected E. coli metal-binding experiment."", ""source_locator"": ""comments[3].cofactors; comments[3].note""}]"	"[{""id"": ""UniProtKB:P22333"", ""source_sha256"": ""23e32e2f4a9fc0b04d71ef7ccef5441c01b1b100951453b1f47d623fe4782181"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P22333"", ""url"": ""https://rest.uniprot.org/uniprotkb/P22333.json""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-031_0d3f94bce1d5	UniProtKB:P0A6K6	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6K6	Alternative metal-supported activities, not simultaneous occupancy or proof of the physiological metal. The source-cited 1970 full paper was inaccessible; no primary metal stoichiometry is inferred.	"[{""reference_id"": ""UniProtKB:P0A6K6"", ""source_assertion"": ""Reviewed DeoB annotates Mn(2+) support: Mn(2+) and Co(2+) are equally good activators; Ni(2+) can substitute less efficiently, attributed to PMID:4992818. The two-Mn binding stoichiometry is separately marked by similarity."", ""source_locator"": ""comments[3].cofactors; comments[3].note.texts[0]""}]"	"[{""id"": ""UniProtKB:P0A6K6"", ""source_sha256"": ""832643bbf42bfcb2ef2e5598e24ff7f18f224bde94291d56a8d5a61bed4b3d66"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0A6K6"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6K6.json""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-032_68cdf907b9fb	UniProtKB:P0A6K6	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6K6	Alternative metal-supported activities, not simultaneous occupancy or proof of the physiological metal. The source-cited 1970 full paper was inaccessible; no primary metal stoichiometry is inferred.	"[{""reference_id"": ""UniProtKB:P0A6K6"", ""source_assertion"": ""Reviewed DeoB annotates Co(2+) support: Mn(2+) and Co(2+) are equally good activators; Ni(2+) can substitute less efficiently, attributed to PMID:4992818. The two-Mn binding stoichiometry is separately marked by similarity."", ""source_locator"": ""comments[3].cofactors; comments[3].note.texts[0]""}]"	"[{""id"": ""UniProtKB:P0A6K6"", ""source_sha256"": ""832643bbf42bfcb2ef2e5598e24ff7f18f224bde94291d56a8d5a61bed4b3d66"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0A6K6"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6K6.json""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-033_1f9f2d37e32c	UniProtKB:P0A6K6	pathwaymech:has_cofactor	CHEBI:49786	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6K6	Alternative metal-supported activities, not simultaneous occupancy or proof of the physiological metal. The source-cited 1970 full paper was inaccessible; no primary metal stoichiometry is inferred.	"[{""reference_id"": ""UniProtKB:P0A6K6"", ""source_assertion"": ""Reviewed DeoB annotates Ni(2+) support: Mn(2+) and Co(2+) are equally good activators; Ni(2+) can substitute less efficiently, attributed to PMID:4992818. The two-Mn binding stoichiometry is separately marked by similarity."", ""source_locator"": ""comments[3].cofactors; comments[3].note.texts[0]""}]"	"[{""id"": ""UniProtKB:P0A6K6"", ""source_sha256"": ""832643bbf42bfcb2ef2e5598e24ff7f18f224bde94291d56a8d5a61bed4b3d66"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0A6K6"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6K6.json""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-034_ea7b7bf3c4c9	UniProtKB:P22333	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P22333		"[{""reference_id"": ""UniProtKB:P22333"", ""source_assertion"": ""The reviewed protein explicitly carries a GO:0005829 cytosol cross-reference with IDA:EcoCyc attribution; this is an inspected database assertion, not a newly repeated localization experiment."", ""source_locator"": ""uniProtKBCrossReferences[database=\""GO\"",id=\""GO:0005829\""].properties; evidences""}]"	"[{""id"": ""UniProtKB:P22333"", ""source_sha256"": ""23e32e2f4a9fc0b04d71ef7ccef5441c01b1b100951453b1f47d623fe4782181"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P22333"", ""url"": ""https://rest.uniprot.org/uniprotkb/P22333.json""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-035_d48141583a76	UniProtKB:P0ABP8	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ABP8		"[{""reference_id"": ""UniProtKB:P0ABP8"", ""source_assertion"": ""The reviewed protein explicitly carries a GO:0005829 cytosol cross-reference with IDA:EcoCyc attribution; this is an inspected database assertion, not a newly repeated localization experiment."", ""source_locator"": ""uniProtKBCrossReferences[database=\""GO\"",id=\""GO:0005829\""].properties; evidences""}]"	"[{""id"": ""UniProtKB:P0ABP8"", ""source_sha256"": ""261a1c1e34fcc0af42d3a3b4a16c27a01ecba13eee2437d3f4d8c51e422eed02"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0ABP8"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABP8.json""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-036_14e2cbffc92b	UniProtKB:P0A6K6	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6K6		"[{""reference_id"": ""UniProtKB:P0A6K6"", ""source_assertion"": ""The reviewed protein explicitly carries a GO:0005829 cytosol cross-reference with IDA:EcoCyc attribution; this is an inspected database assertion, not a newly repeated localization experiment."", ""source_locator"": ""uniProtKBCrossReferences[database=\""GO\"",id=\""GO:0005829\""].properties; evidences""}]"	"[{""id"": ""UniProtKB:P0A6K6"", ""source_sha256"": ""832643bbf42bfcb2ef2e5598e24ff7f18f224bde94291d56a8d5a61bed4b3d66"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0A6K6"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6K6.json""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-037_52af4c1fca8e	UniProtKB:P0A6L0	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6L0		"[{""reference_id"": ""UniProtKB:P0A6L0"", ""source_assertion"": ""The reviewed protein explicitly carries a GO:0005829 cytosol cross-reference with IDA:EcoCyc attribution; this is an inspected database assertion, not a newly repeated localization experiment."", ""source_locator"": ""uniProtKBCrossReferences[database=\""GO\"",id=\""GO:0005829\""].properties; evidences""}]"	"[{""id"": ""UniProtKB:P0A6L0"", ""source_sha256"": ""01150821cd4ffac2f7a86659cd71e2304bb63dc76c118e7ae3716d8812b1f76c"", ""source_version"": ""UniProt release 2026_03; response release date 02-September-2026"", ""title"": ""Reviewed UniProtKB P0A6L0"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6L0.json""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-038_8083b56d88ca	MetaCyc:DEOD-CPLX	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOD-CPLX		"[{""reference_id"": ""MetaCyc:DEOD-CPLX"", ""source_assertion"": ""The native DEOD-CPLX location is CCO-CYTOSOL, the cytosolic compartment."", ""source_locator"": ""Protein[@frameid=\""DEOD-CPLX\""]/location""}]"	"[{""id"": ""MetaCyc:DEOD-CPLX"", ""source_sha256"": ""f362dcc29babaf5d23e730a329a7c436a0944d811a36ad1adb8ee8569e7962e5"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOD-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOD-CPLX""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-039_692b273e84db	RHEA:28191	BFO:0000050	PathBank:SMP0002089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ADDALT-RXN|PathBank:SMP0002089|RHEA:28191	Native generic/protonation forms are projected to the exact reviewed-enzyme Rhea species; no exactMatch between different ChEBI forms is asserted. Native 6068 is written right-to-left, which is the selected deamination direction.	"[{""reference_id"": ""PathBank:SMP0002089"", ""source_assertion"": ""The exact pathway SMP0002089 declares Reactions/6068 as a pathway component and links it to a step. Its substrates, products and catalyst correspond to this selected degradation reaction; all native chemical roles are retained."", ""source_locator"": ""bp:Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002089\""]/bp:pathwayComponent; bp:BiochemicalReaction[@rdf:ID=\""Reactions/6068\""]; linked bp:Catalysis""}, {""reference_id"": ""MetaCyc:ADDALT-RXN"", ""source_assertion"": ""Native reaction ADDALT-RXN has Rhea cross-reference 28190; its enzyme and chemical identities support the bridge from the PathBank reaction to this Rhea family."", ""source_locator"": ""Reaction[@frameid=\""ADDALT-RXN\""]/dblink[dblink-db=\""RHEA\""], left, right, enzymatic-reaction""}, {""reference_id"": ""RHEA:28191"", ""source_assertion"": ""Rhea master 28190 explicitly links directed left-to-right member 28191."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28190\""]/rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:ADDALT-RXN"", ""source_sha256"": ""4fb48d64f28672b87f542d1a7ba787c426ab0c637fdd4a701cad7951c395a4e3"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native ADDALT-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADDALT-RXN""}, {""id"": ""PathBank:SMP0002089"", ""source_sha256"": ""c515d4778a7c92d66060ceeffac95c89149cc5400e388e1110fc2cd95fc040a6"", ""source_version"": ""Native BioPAX PW002077.owl from primary archive; SHA256 covers uncompressed member bytes"", ""title"": ""PathBank native purine deoxyribonucleosides degradation"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:28191"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 28191"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-040_548eb8c3462f	RHEA:27743	BFO:0000050	PathBank:SMP0002089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOXYADENPHOSPHOR-RXN|PathBank:SMP0002089|RHEA:27743	Native generic/protonation forms are projected to the exact reviewed-enzyme Rhea species; no exactMatch between different ChEBI forms is asserted.	"[{""reference_id"": ""PathBank:SMP0002089"", ""source_assertion"": ""The exact pathway SMP0002089 declares Reactions/6069 as a pathway component and links it to a step. Its substrates, products and catalyst correspond to this selected degradation reaction; all native chemical roles are retained."", ""source_locator"": ""bp:Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002089\""]/bp:pathwayComponent; bp:BiochemicalReaction[@rdf:ID=\""Reactions/6069\""]; linked bp:Catalysis""}, {""reference_id"": ""MetaCyc:DEOXYADENPHOSPHOR-RXN"", ""source_assertion"": ""Native reaction DEOXYADENPHOSPHOR-RXN has Rhea cross-reference 27745; its enzyme and chemical identities support the bridge from the PathBank reaction to this Rhea family."", ""source_locator"": ""Reaction[@frameid=\""DEOXYADENPHOSPHOR-RXN\""]/dblink[dblink-db=\""RHEA\""], left, right, enzymatic-reaction""}, {""reference_id"": ""RHEA:27743"", ""source_assertion"": ""Rhea master 27742 explicitly links directed left-to-right member 27743 and bidirectional member 27745."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/27742\""]/rh:directionalReaction; rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:DEOXYADENPHOSPHOR-RXN"", ""source_sha256"": ""2b49ac7da21543fd914a87ba30314e6e7be46ca85562cdf5c3e67f2613a587ec"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOXYADENPHOSPHOR-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOXYADENPHOSPHOR-RXN""}, {""id"": ""PathBank:SMP0002089"", ""source_sha256"": ""c515d4778a7c92d66060ceeffac95c89149cc5400e388e1110fc2cd95fc040a6"", ""source_version"": ""Native BioPAX PW002077.owl from primary archive; SHA256 covers uncompressed member bytes"", ""title"": ""PathBank native purine deoxyribonucleosides degradation"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:27743"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27743"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-041_0b3680b15853	RHEA:27751	BFO:0000050	PathBank:SMP0002089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOXYINOPHOSPHOR-RXN|PathBank:SMP0002089|RHEA:27751	Native generic/protonation forms are projected to the exact reviewed-enzyme Rhea species; no exactMatch between different ChEBI forms is asserted.	"[{""reference_id"": ""PathBank:SMP0002089"", ""source_assertion"": ""The exact pathway SMP0002089 declares Reactions/6067 as a pathway component and links it to a step. Its substrates, products and catalyst correspond to this selected degradation reaction; all native chemical roles are retained."", ""source_locator"": ""bp:Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002089\""]/bp:pathwayComponent; bp:BiochemicalReaction[@rdf:ID=\""Reactions/6067\""]; linked bp:Catalysis""}, {""reference_id"": ""MetaCyc:DEOXYINOPHOSPHOR-RXN"", ""source_assertion"": ""Native reaction DEOXYINOPHOSPHOR-RXN has Rhea cross-reference 27753; its enzyme and chemical identities support the bridge from the PathBank reaction to this Rhea family."", ""source_locator"": ""Reaction[@frameid=\""DEOXYINOPHOSPHOR-RXN\""]/dblink[dblink-db=\""RHEA\""], left, right, enzymatic-reaction""}, {""reference_id"": ""RHEA:27751"", ""source_assertion"": ""Rhea master 27750 explicitly links directed left-to-right member 27751 and bidirectional member 27753."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/27750\""]/rh:directionalReaction; rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:DEOXYINOPHOSPHOR-RXN"", ""source_sha256"": ""0e10cfd347853ca7ca5be099946df4c6c85238485a4832abbd98fb35fe4982eb"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOXYINOPHOSPHOR-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOXYINOPHOSPHOR-RXN""}, {""id"": ""PathBank:SMP0002089"", ""source_sha256"": ""c515d4778a7c92d66060ceeffac95c89149cc5400e388e1110fc2cd95fc040a6"", ""source_version"": ""Native BioPAX PW002077.owl from primary archive; SHA256 covers uncompressed member bytes"", ""title"": ""PathBank native purine deoxyribonucleosides degradation"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:27751"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27751"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-042_f6a7fd46fdea	RHEA:27739	BFO:0000050	PathBank:SMP0002089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOXYGUANPHOSPHOR-RXN|PathBank:SMP0002089|RHEA:27739	Native generic/protonation forms are projected to the exact reviewed-enzyme Rhea species; no exactMatch between different ChEBI forms is asserted.	"[{""reference_id"": ""PathBank:SMP0002089"", ""source_assertion"": ""The exact pathway SMP0002089 declares Reactions/6070 as a pathway component and links it to a step. Its substrates, products and catalyst correspond to this selected degradation reaction; all native chemical roles are retained."", ""source_locator"": ""bp:Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002089\""]/bp:pathwayComponent; bp:BiochemicalReaction[@rdf:ID=\""Reactions/6070\""]; linked bp:Catalysis""}, {""reference_id"": ""MetaCyc:DEOXYGUANPHOSPHOR-RXN"", ""source_assertion"": ""Native reaction DEOXYGUANPHOSPHOR-RXN has Rhea cross-reference 27741; its enzyme and chemical identities support the bridge from the PathBank reaction to this Rhea family."", ""source_locator"": ""Reaction[@frameid=\""DEOXYGUANPHOSPHOR-RXN\""]/dblink[dblink-db=\""RHEA\""], left, right, enzymatic-reaction""}, {""reference_id"": ""RHEA:27739"", ""source_assertion"": ""Rhea master 27738 explicitly links directed left-to-right member 27739 and bidirectional member 27741."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/27738\""]/rh:directionalReaction; rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:DEOXYGUANPHOSPHOR-RXN"", ""source_sha256"": ""3248226e74802bf466aea7bb6ace0ad6d145cd59afe1243b49c49a2a0c0d110b"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOXYGUANPHOSPHOR-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOXYGUANPHOSPHOR-RXN""}, {""id"": ""PathBank:SMP0002089"", ""source_sha256"": ""c515d4778a7c92d66060ceeffac95c89149cc5400e388e1110fc2cd95fc040a6"", ""source_version"": ""Native BioPAX PW002077.owl from primary archive; SHA256 covers uncompressed member bytes"", ""title"": ""PathBank native purine deoxyribonucleosides degradation"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:27739"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27739"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-043_7aa0a6534c56	RHEA:27659	BFO:0000050	PathBank:SMP0002089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:D-PPENTOMUT-RXN|PathBank:SMP0002089|RHEA:27659	Native generic/protonation forms are projected to the exact reviewed-enzyme Rhea species; no exactMatch between different ChEBI forms is asserted.	"[{""reference_id"": ""PathBank:SMP0002089"", ""source_assertion"": ""The exact pathway SMP0002089 declares Reactions/6071 as a pathway component and links it to a step. Its substrates, products and catalyst correspond to this selected degradation reaction; all native chemical roles are retained."", ""source_locator"": ""bp:Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002089\""]/bp:pathwayComponent; bp:BiochemicalReaction[@rdf:ID=\""Reactions/6071\""]; linked bp:Catalysis""}, {""reference_id"": ""MetaCyc:D-PPENTOMUT-RXN"", ""source_assertion"": ""Native reaction D-PPENTOMUT-RXN has Rhea cross-reference 27661; its enzyme and chemical identities support the bridge from the PathBank reaction to this Rhea family."", ""source_locator"": ""Reaction[@frameid=\""D-PPENTOMUT-RXN\""]/dblink[dblink-db=\""RHEA\""], left, right, enzymatic-reaction""}, {""reference_id"": ""RHEA:27659"", ""source_assertion"": ""Rhea master 27658 explicitly links directed left-to-right member 27659 and bidirectional member 27661."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/27658\""]/rh:directionalReaction; rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:D-PPENTOMUT-RXN"", ""source_sha256"": ""fafeddb75d6c4beab4e5170e978899d1d7b75ec753653a66b7e20d735ba96b07"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native D-PPENTOMUT-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:D-PPENTOMUT-RXN""}, {""id"": ""PathBank:SMP0002089"", ""source_sha256"": ""c515d4778a7c92d66060ceeffac95c89149cc5400e388e1110fc2cd95fc040a6"", ""source_version"": ""Native BioPAX PW002077.owl from primary archive; SHA256 covers uncompressed member bytes"", ""title"": ""PathBank native purine deoxyribonucleosides degradation"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:27659"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27659"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-044_6c065faf84c6	RHEA:12822	BFO:0000050	PathBank:SMP0002089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOXYRIBOSE-P-ALD-RXN|PathBank:SMP0002089|RHEA:12822	Native generic/protonation forms are projected to the exact reviewed-enzyme Rhea species; no exactMatch between different ChEBI forms is asserted.	"[{""reference_id"": ""PathBank:SMP0002089"", ""source_assertion"": ""The exact pathway SMP0002089 declares Reactions/6072 as a pathway component and links it to a step. Its substrates, products and catalyst correspond to this selected degradation reaction; all native chemical roles are retained."", ""source_locator"": ""bp:Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002089\""]/bp:pathwayComponent; bp:BiochemicalReaction[@rdf:ID=\""Reactions/6072\""]; linked bp:Catalysis""}, {""reference_id"": ""MetaCyc:DEOXYRIBOSE-P-ALD-RXN"", ""source_assertion"": ""Native reaction DEOXYRIBOSE-P-ALD-RXN has Rhea cross-reference 12824; its enzyme and chemical identities support the bridge from the PathBank reaction to this Rhea family."", ""source_locator"": ""Reaction[@frameid=\""DEOXYRIBOSE-P-ALD-RXN\""]/dblink[dblink-db=\""RHEA\""], left, right, enzymatic-reaction""}, {""reference_id"": ""RHEA:12822"", ""source_assertion"": ""Rhea master 12821 explicitly links directed left-to-right member 12822 and bidirectional member 12824."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/12821\""]/rh:directionalReaction; rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:DEOXYRIBOSE-P-ALD-RXN"", ""source_sha256"": ""b0d4a64b4370fcd228c6aeb287c0c216e892770b7bd653dc18afd825287236a9"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOXYRIBOSE-P-ALD-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOXYRIBOSE-P-ALD-RXN""}, {""id"": ""PathBank:SMP0002089"", ""source_sha256"": ""c515d4778a7c92d66060ceeffac95c89149cc5400e388e1110fc2cd95fc040a6"", ""source_version"": ""Native BioPAX PW002077.owl from primary archive; SHA256 covers uncompressed member bytes"", ""title"": ""PathBank native purine deoxyribonucleosides degradation"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:12822"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 12822"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-045_d062cfe6b327	RHEA:28191	RO:0002413	RHEA:27751	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27751|RHEA:28191	Material transfer through the exact shared intermediate; diagram array ordering is not treated as a causal chain between parallel branches.	"[{""reference_id"": ""RHEA:28191"", ""source_assertion"": ""This directed reaction produces CHEBI:28997; the linked product compound supplies the chemically identical intermediate consumed by RHEA:27751."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/28191\""]/rh:products; side/rh:contains1/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:27751"", ""source_assertion"": ""This directed reaction consumes CHEBI:28997, the exact species produced by RHEA:28191."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/27751\""]/rh:substrates; side/rh:contains1/rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27751"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27751"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:28191"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 28191"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-046_2d786f82055c	RHEA:27743	RO:0002413	RHEA:27659	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27659|RHEA:27743	Material transfer through the exact shared intermediate; diagram array ordering is not treated as a causal chain between parallel branches.	"[{""reference_id"": ""RHEA:27743"", ""source_assertion"": ""This directed reaction produces CHEBI:57259; the linked product compound supplies the chemically identical intermediate consumed by RHEA:27659."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/27743\""]/rh:products; side/rh:contains1/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:27659"", ""source_assertion"": ""This directed reaction consumes CHEBI:57259, the exact species produced by RHEA:27743."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/27659\""]/rh:substrates; side/rh:contains1/rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27659"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27659"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:27743"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27743"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-047_99200140e972	RHEA:27751	RO:0002413	RHEA:27659	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27659|RHEA:27751	Material transfer through the exact shared intermediate; diagram array ordering is not treated as a causal chain between parallel branches.	"[{""reference_id"": ""RHEA:27751"", ""source_assertion"": ""This directed reaction produces CHEBI:57259; the linked product compound supplies the chemically identical intermediate consumed by RHEA:27659."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/27751\""]/rh:products; side/rh:contains1/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:27659"", ""source_assertion"": ""This directed reaction consumes CHEBI:57259, the exact species produced by RHEA:27751."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/27659\""]/rh:substrates; side/rh:contains1/rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27659"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27659"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:27751"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27751"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-048_a4058320e1e2	RHEA:27739	RO:0002413	RHEA:27659	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27659|RHEA:27739	Material transfer through the exact shared intermediate; diagram array ordering is not treated as a causal chain between parallel branches.	"[{""reference_id"": ""RHEA:27739"", ""source_assertion"": ""This directed reaction produces CHEBI:57259; the linked product compound supplies the chemically identical intermediate consumed by RHEA:27659."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/27739\""]/rh:products; side/rh:contains1/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:27659"", ""source_assertion"": ""This directed reaction consumes CHEBI:57259, the exact species produced by RHEA:27739."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/27659\""]/rh:substrates; side/rh:contains1/rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27659"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27659"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:27739"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27739"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002089_purine-deoxy-edge-049_6426033c08b4	RHEA:27659	RO:0002413	RHEA:12822	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12822|RHEA:27659	Material transfer through the exact shared intermediate; diagram array ordering is not treated as a causal chain between parallel branches.	"[{""reference_id"": ""RHEA:27659"", ""source_assertion"": ""This directed reaction produces CHEBI:62877; the linked product compound supplies the chemically identical intermediate consumed by RHEA:12822."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/27659\""]/rh:products; side/rh:contains1/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:12822"", ""source_assertion"": ""This directed reaction consumes CHEBI:62877, the exact species produced by RHEA:27659."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/12822\""]/rh:substrates; side/rh:contains1/rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:12822"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 12822"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:27659"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; SHA256 covers complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 27659"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-001_85e10189a4ee	CHEBI:326268	pathwaymech:consumes	RHEA:13634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13633	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:13633"", ""source_assertion"": ""RHEA:13634 substrates 13633_L contains1 Participant_13633_compound_4665, whose compound is CHEBI:326268."", ""source_locator"": ""http://rdf.rhea-db.org/13634 rh:substrates; http://rdf.rhea-db.org/13633_L rh:contains1 http://rdf.rhea-db.org/Participant_13633_compound_4665; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13633"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:13633 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/13633""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-002_d54950b53faa	CHEBI:29985	pathwaymech:consumes	RHEA:13634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13633	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:13633"", ""source_assertion"": ""RHEA:13634 substrates 13633_L contains1 Participant_13633_compound_2079, whose compound is CHEBI:29985."", ""source_locator"": ""http://rdf.rhea-db.org/13634 rh:substrates; http://rdf.rhea-db.org/13633_L rh:contains1 http://rdf.rhea-db.org/Participant_13633_compound_2079; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13633"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:13633 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/13633""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-003_b0c75661c54a	CHEBI:30616	pathwaymech:consumes	RHEA:13634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13633	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:13633"", ""source_assertion"": ""RHEA:13634 substrates 13633_L contains1 Participant_13633_compound_6372, whose compound is CHEBI:30616."", ""source_locator"": ""http://rdf.rhea-db.org/13634 rh:substrates; http://rdf.rhea-db.org/13633_L rh:contains1 http://rdf.rhea-db.org/Participant_13633_compound_6372; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13633"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:13633 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/13633""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-004_4966076a6d31	RHEA:13634	pathwaymech:produces	CHEBI:58731	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13633	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:13633"", ""source_assertion"": ""RHEA:13634 products 13633_R contains1 Participant_13633_compound_5250, whose compound is CHEBI:58731."", ""source_locator"": ""http://rdf.rhea-db.org/13634 rh:products; http://rdf.rhea-db.org/13633_R rh:contains1 http://rdf.rhea-db.org/Participant_13633_compound_5250; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13633"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:13633 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/13633""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-005_f878f4fd30c7	RHEA:13634	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13633	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:13633"", ""source_assertion"": ""RHEA:13634 products 13633_R contains1 Participant_13633_compound_2710, whose compound is CHEBI:456216."", ""source_locator"": ""http://rdf.rhea-db.org/13634 rh:products; http://rdf.rhea-db.org/13633_R rh:contains1 http://rdf.rhea-db.org/Participant_13633_compound_2710; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13633"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:13633 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/13633""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-006_c0abed8db729	RHEA:13634	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13633	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:13633"", ""source_assertion"": ""RHEA:13634 products 13633_R contains1 Participant_13633_compound_5518, whose compound is CHEBI:43474."", ""source_locator"": ""http://rdf.rhea-db.org/13634 rh:products; http://rdf.rhea-db.org/13633_R rh:contains1 http://rdf.rhea-db.org/Participant_13633_compound_5518; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13633"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:13633 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/13633""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-007_ea35e6e31cd7	RHEA:13634	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13633	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:13633"", ""source_assertion"": ""RHEA:13634 products 13633_R contains1 Participant_13633_compound_3249, whose compound is CHEBI:15378."", ""source_locator"": ""http://rdf.rhea-db.org/13634 rh:products; http://rdf.rhea-db.org/13633_R rh:contains1 http://rdf.rhea-db.org/Participant_13633_compound_3249; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13633"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:13633 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/13633""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-008_7df23965d918	CHEBI:58731	pathwaymech:consumes	RHEA:28415	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28414	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:28414"", ""source_assertion"": ""RHEA:28415 substrates 28414_L contains1 Participant_28414_compound_5250, whose compound is CHEBI:58731."", ""source_locator"": ""http://rdf.rhea-db.org/28415 rh:substrates; http://rdf.rhea-db.org/28414_L rh:contains1 http://rdf.rhea-db.org/Participant_28414_compound_5250; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28414"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:28414 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/28414""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-009_c87fc793b500	CHEBI:15379	pathwaymech:consumes	RHEA:28415	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28414	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:28414"", ""source_assertion"": ""RHEA:28415 substrates 28414_L contains1 Participant_28414_compound_1198, whose compound is CHEBI:15379."", ""source_locator"": ""http://rdf.rhea-db.org/28415 rh:substrates; http://rdf.rhea-db.org/28414_L rh:contains1 http://rdf.rhea-db.org/Participant_28414_compound_1198; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28414"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:28414 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/28414""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-010_36e9df872cc6	CHEBI:15377	pathwaymech:consumes	RHEA:28415	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28414	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form. Water follows Rhea and UniProt; the native PathBank equation instead lists a hydron and is not copied.	"[{""reference_id"": ""RHEA:28414"", ""source_assertion"": ""RHEA:28415 substrates 28414_L contains1 Participant_28414_compound_1283, whose compound is CHEBI:15377."", ""source_locator"": ""http://rdf.rhea-db.org/28415 rh:substrates; http://rdf.rhea-db.org/28414_L rh:contains1 http://rdf.rhea-db.org/Participant_28414_compound_1283; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28414"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:28414 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/28414""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-011_d1058cdec6ac	RHEA:28415	pathwaymech:produces	CHEBI:61508	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:61508|RHEA:28414	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form. The gamma-glutamyl amide topology is grounded independently in ChEBI; the conflicting native SMILES is rejected.	"[{""reference_id"": ""RHEA:28414"", ""source_assertion"": ""RHEA:28415 products 28414_R contains1 Participant_28414_compound_6458, whose compound is CHEBI:61508."", ""source_locator"": ""http://rdf.rhea-db.org/28415 rh:products; http://rdf.rhea-db.org/28414_R rh:contains1 http://rdf.rhea-db.org/Participant_28414_compound_6458; rh:compound/rh:accession""}, {""reference_id"": ""CHEBI:61508"", ""source_assertion"": ""CHEBI:61508 is the gamma-glutamyl-gamma-aminobutyraldehyde zwitterion, charge 0, with SMILES [H]C(=O)CCCNC(=O)CC[C@H]([NH3+])C(=O)[O-]."", ""source_locator"": ""ChEBI release255 SemanticSQL statements subject=CHEBI:61508, predicates rdfs:label, chemrof:charge, chemrof:smiles_string""}]"	"[{""id"": ""CHEBI:61508"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI255; exact issuing-authority statements inspected in SemanticSQL; digest covers the complete uncompressed chebi.db cache, not this webpage"", ""title"": ""ChEBI CHEBI:61508 exact structure and charge"", ""url"": ""https://www.ebi.ac.uk/chebi/CHEBI:61508""}, {""id"": ""RHEA:28414"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:28414 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/28414""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-012_4c7ef024a4f9	RHEA:28415	pathwaymech:produces	CHEBI:16240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28414	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:28414"", ""source_assertion"": ""RHEA:28415 products 28414_R contains1 Participant_28414_compound_3075, whose compound is CHEBI:16240."", ""source_locator"": ""http://rdf.rhea-db.org/28415 rh:products; http://rdf.rhea-db.org/28414_R rh:contains1 http://rdf.rhea-db.org/Participant_28414_compound_3075; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28414"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:28414 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/28414""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-013_5b80ff1851ba	RHEA:28415	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28414	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:28414"", ""source_assertion"": ""RHEA:28415 products 28414_R contains1 Participant_28414_compound_1012, whose compound is CHEBI:28938."", ""source_locator"": ""http://rdf.rhea-db.org/28415 rh:products; http://rdf.rhea-db.org/28414_R rh:contains1 http://rdf.rhea-db.org/Participant_28414_compound_1012; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28414"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:28414 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/28414""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-014_e77a9ed892de	CHEBI:61508	pathwaymech:consumes	RHEA:28411	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:61508|RHEA:28410	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form. The gamma-glutamyl amide topology is grounded independently in ChEBI; the conflicting native SMILES is rejected.	"[{""reference_id"": ""RHEA:28410"", ""source_assertion"": ""RHEA:28411 substrates 28410_L contains1 Participant_28410_compound_6458, whose compound is CHEBI:61508."", ""source_locator"": ""http://rdf.rhea-db.org/28411 rh:substrates; http://rdf.rhea-db.org/28410_L rh:contains1 http://rdf.rhea-db.org/Participant_28410_compound_6458; rh:compound/rh:accession""}, {""reference_id"": ""CHEBI:61508"", ""source_assertion"": ""CHEBI:61508 is the gamma-glutamyl-gamma-aminobutyraldehyde zwitterion, charge 0, with SMILES [H]C(=O)CCCNC(=O)CC[C@H]([NH3+])C(=O)[O-]."", ""source_locator"": ""ChEBI release255 SemanticSQL statements subject=CHEBI:61508, predicates rdfs:label, chemrof:charge, chemrof:smiles_string""}]"	"[{""id"": ""CHEBI:61508"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI255; exact issuing-authority statements inspected in SemanticSQL; digest covers the complete uncompressed chebi.db cache, not this webpage"", ""title"": ""ChEBI CHEBI:61508 exact structure and charge"", ""url"": ""https://www.ebi.ac.uk/chebi/CHEBI:61508""}, {""id"": ""RHEA:28410"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:28410 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/28410""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-015_b1652e99c6a1	CHEBI:58349	pathwaymech:consumes	RHEA:28411	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28410	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:28410"", ""source_assertion"": ""RHEA:28411 substrates 28410_L contains1 Participant_28410_compound_5188, whose compound is CHEBI:58349."", ""source_locator"": ""http://rdf.rhea-db.org/28411 rh:substrates; http://rdf.rhea-db.org/28410_L rh:contains1 http://rdf.rhea-db.org/Participant_28410_compound_5188; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28410"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:28410 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/28410""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-016_e63fee81dd0f	CHEBI:15377	pathwaymech:consumes	RHEA:28411	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28410	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:28410"", ""source_assertion"": ""RHEA:28411 substrates 28410_L contains1 Participant_28410_compound_1283, whose compound is CHEBI:15377."", ""source_locator"": ""http://rdf.rhea-db.org/28411 rh:substrates; http://rdf.rhea-db.org/28410_L rh:contains1 http://rdf.rhea-db.org/Participant_28410_compound_1283; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28410"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:28410 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/28410""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-017_5cadbea6c143	RHEA:28411	pathwaymech:produces	CHEBI:58800	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:58800|RHEA:28410	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form. The gamma-glutamyl amide topology is grounded independently in ChEBI; the conflicting native SMILES is rejected.	"[{""reference_id"": ""RHEA:28410"", ""source_assertion"": ""RHEA:28411 products 28410_R contains1 Participant_28410_compound_5582, whose compound is CHEBI:58800."", ""source_locator"": ""http://rdf.rhea-db.org/28411 rh:products; http://rdf.rhea-db.org/28410_R rh:contains1 http://rdf.rhea-db.org/Participant_28410_compound_5582; rh:compound/rh:accession""}, {""reference_id"": ""CHEBI:58800"", ""source_assertion"": ""CHEBI:58800 has charge -1 and stereodefined SMILES [NH3+][C@@H](CCC(=O)NCCCC(=O)[O-])C(=O)[O-], preserving the gamma-glutamyl amide."", ""source_locator"": ""ChEBI release255 SemanticSQL statements subject=CHEBI:58800, predicates rdfs:label, chemrof:charge, chemrof:smiles_string""}]"	"[{""id"": ""CHEBI:58800"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI255; exact issuing-authority statements inspected in SemanticSQL; digest covers the complete uncompressed chebi.db cache, not this webpage"", ""title"": ""ChEBI CHEBI:58800 exact structure and charge"", ""url"": ""https://www.ebi.ac.uk/chebi/CHEBI:58800""}, {""id"": ""RHEA:28410"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:28410 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/28410""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-018_f4ef4e7101b1	RHEA:28411	pathwaymech:produces	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28410	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:28410"", ""source_assertion"": ""RHEA:28411 products 28410_R contains1 Participant_28410_compound_3438, whose compound is CHEBI:57783."", ""source_locator"": ""http://rdf.rhea-db.org/28411 rh:products; http://rdf.rhea-db.org/28410_R rh:contains1 http://rdf.rhea-db.org/Participant_28410_compound_3438; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28410"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:28410 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/28410""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-019_d894c5d79eb3	RHEA:28411	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28410	Coefficient 2 in the selected catabolic Rhea direction; exact source charge and stereochemical form. Two hydrons are produced; one edge retains the source coefficient explicitly.	"[{""reference_id"": ""RHEA:28410"", ""source_assertion"": ""RHEA:28411 products 28410_R contains2 Participant_28410_compound_3249, whose compound is CHEBI:15378."", ""source_locator"": ""http://rdf.rhea-db.org/28411 rh:products; http://rdf.rhea-db.org/28410_R rh:contains2 http://rdf.rhea-db.org/Participant_28410_compound_3249; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28410"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:28410 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/28410""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-020_7d8f898fd743	CHEBI:58800	pathwaymech:consumes	RHEA:19738	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:58800|RHEA:19737	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form. The gamma-glutamyl amide topology is grounded independently in ChEBI; the conflicting native SMILES is rejected.	"[{""reference_id"": ""RHEA:19737"", ""source_assertion"": ""RHEA:19738 substrates 19737_L contains1 Participant_19737_compound_5582, whose compound is CHEBI:58800."", ""source_locator"": ""http://rdf.rhea-db.org/19738 rh:substrates; http://rdf.rhea-db.org/19737_L rh:contains1 http://rdf.rhea-db.org/Participant_19737_compound_5582; rh:compound/rh:accession""}, {""reference_id"": ""CHEBI:58800"", ""source_assertion"": ""CHEBI:58800 has charge -1 and stereodefined SMILES [NH3+][C@@H](CCC(=O)NCCCC(=O)[O-])C(=O)[O-], preserving the gamma-glutamyl amide."", ""source_locator"": ""ChEBI release255 SemanticSQL statements subject=CHEBI:58800, predicates rdfs:label, chemrof:charge, chemrof:smiles_string""}]"	"[{""id"": ""CHEBI:58800"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI255; exact issuing-authority statements inspected in SemanticSQL; digest covers the complete uncompressed chebi.db cache, not this webpage"", ""title"": ""ChEBI CHEBI:58800 exact structure and charge"", ""url"": ""https://www.ebi.ac.uk/chebi/CHEBI:58800""}, {""id"": ""RHEA:19737"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:19737 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/19737""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-021_0338ccf8fe84	CHEBI:15377	pathwaymech:consumes	RHEA:19738	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19737	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:19737"", ""source_assertion"": ""RHEA:19738 substrates 19737_L contains1 Participant_19737_compound_1283, whose compound is CHEBI:15377."", ""source_locator"": ""http://rdf.rhea-db.org/19738 rh:substrates; http://rdf.rhea-db.org/19737_L rh:contains1 http://rdf.rhea-db.org/Participant_19737_compound_1283; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19737"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:19737 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/19737""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-022_bf987f9027da	RHEA:19738	pathwaymech:produces	CHEBI:59888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19737	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:19737"", ""source_assertion"": ""RHEA:19738 products 19737_R contains1 Participant_19737_compound_6180, whose compound is CHEBI:59888."", ""source_locator"": ""http://rdf.rhea-db.org/19738 rh:products; http://rdf.rhea-db.org/19737_R rh:contains1 http://rdf.rhea-db.org/Participant_19737_compound_6180; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19737"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:19737 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/19737""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-023_43bc7023e9f4	RHEA:19738	pathwaymech:produces	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19737	Coefficient 1 in the selected catabolic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:19737"", ""source_assertion"": ""RHEA:19738 products 19737_R contains1 Participant_19737_compound_2079, whose compound is CHEBI:29985."", ""source_locator"": ""http://rdf.rhea-db.org/19738 rh:products; http://rdf.rhea-db.org/19737_R rh:contains1 http://rdf.rhea-db.org/Participant_19737_compound_2079; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19737"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:19737 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/19737""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-024_1a3f5bc7b461	PathBank:SMP0002067/ProteinComplex/4033	pathwaymech:catalyzes	RHEA:13634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:18495664|PathBank:SMP0002067|UniProtKB:P78061	The source-defined PuuA dodecamer catalyzes ATP-dependent gamma-glutamylation; the protein subunit is not separately asserted to catalyze as a monomer.	"[{""reference_id"": ""PathBank:SMP0002067"", ""source_assertion"": ""Catalysis 5960 connects native controller ProteinComplex/4033 to Reactions/5997. The Rhea reconstruction is grounded separately in UniProt, not a native PathBank Rhea xref."", ""source_locator"": ""#ReactionCatalysis/5960 bp:controller,bp:controlled""}, {""reference_id"": ""UniProtKB:P78061"", ""source_assertion"": ""P78061 CATALYTIC ACTIVITY assigns RHEA:13633; ECO:0000269 supports this catalytic annotation."", ""source_locator"": ""primaryAccession; comments[commentType=CATALYTIC ACTIVITY].reaction[reactionCrossReferences.id=RHEA:13633]; comments[commentType=FUNCTION]""}, {""quote"": ""Purified non-tagged PuuA catalyzed the ATP-dependent gamma-glutamylation of putrescine."", ""reference_id"": ""PMID:18495664""}]"	"[{""id"": ""PMID:18495664"", ""source_sha256"": ""2ba64d737aee6d12255978ac5bfb29c59ab71c4ece1171bb160e02197a5e2dd4"", ""source_version"": ""primary abstract in Europe PMC core response accessed 2026-10-10; DOI 10.1074/jbc.m800133200"", ""title"": ""gamma-Glutamylputrescine synthetase in the putrescine utilization pathway of Escherichia coli K-12."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/18495664/""}, {""id"": ""PathBank:SMP0002067"", ""source_sha256"": ""0aa406cfc7c31bc502c695a85a4d1c5b2bf2c8d9d2de4bba6e45195b5a86585e"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002054.owl; accessed 2026-10-10"", ""title"": ""PathBank Putrescine Degradation II native BioPAX pathway"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P78061"", ""source_sha256"": ""53e5074fa605000a5642112147053c2c5b3c8e4a45fecf8ea7aa18f2ba932c22"", ""source_version"": ""accessed 2026-10-10; entry version 166; sequence version 2"", ""title"": ""Gamma-glutamylputrescine synthetase PuuA — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P78061.json""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-025_85bd68fa3c2e	UniProtKB:P37906	pathwaymech:catalyzes	RHEA:28415	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:15590624|PathBank:SMP0002067|UniProtKB:P37906	PuuB catalyzes oxygen-dependent oxidative deamination. UniProt FUNCTION carries ECO:0000269 PMID15590624; its catalytic equation and step 2/4 annotation have no separate evidence code and are not upgraded to a purified-enzyme experiment.	"[{""reference_id"": ""PathBank:SMP0002067"", ""source_assertion"": ""Catalysis 5961 connects native controller Protein/6593 to Reactions/5998. The Rhea reconstruction is grounded separately in UniProt, not a native PathBank Rhea xref."", ""source_locator"": ""#ReactionCatalysis/5961 bp:controller,bp:controlled""}, {""reference_id"": ""UniProtKB:P37906"", ""source_assertion"": ""P37906 CATALYTIC ACTIVITY assigns RHEA:28414; FUNCTION has ECO:0000269 PMID15590624; CATALYTIC ACTIVITY itself has no explicit ECO annotation."", ""source_locator"": ""primaryAccession; comments[commentType=CATALYTIC ACTIVITY].reaction[reactionCrossReferences.id=RHEA:28414]; comments[commentType=FUNCTION]""}, {""quote"": ""oxidization of gamma-glutamylputrescine"", ""reference_id"": ""PMID:15590624""}]"	"[{""id"": ""PMID:15590624"", ""source_sha256"": ""e12c1d8a9c6c63a70230c956dc2bd2f2738ee6e535b0d064985a4fedb4582be3"", ""source_version"": ""primary abstract in Europe PMC core response accessed 2026-10-10; DOI 10.1074/jbc.m411114200"", ""title"": ""A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/15590624/""}, {""id"": ""PathBank:SMP0002067"", ""source_sha256"": ""0aa406cfc7c31bc502c695a85a4d1c5b2bf2c8d9d2de4bba6e45195b5a86585e"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002054.owl; accessed 2026-10-10"", ""title"": ""PathBank Putrescine Degradation II native BioPAX pathway"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P37906"", ""source_sha256"": ""e2c52cd03cf231f49551c23173acd8ce5b5c4782cdeb7917428146506c65ba25"", ""source_version"": ""accessed 2026-10-10; entry version 163; sequence version 2"", ""title"": ""Gamma-glutamylputrescine oxidoreductase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37906.json""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-026_b0a7a697e8fe	UniProtKB:P23883	pathwaymech:catalyzes	RHEA:28411	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:15590624|PathBank:SMP0002067|UniProtKB:P23883	PuuC catalyzes the selected NADP-dependent reaction (ECO:0000269 PMID15590624). Its NAD-dependent variant is also supported (RHEA:42340/42341); selection here does not imply NADP specificity. Other PuuC aldehyde substrates and downstream reactions are excluded.	"[{""reference_id"": ""PathBank:SMP0002067"", ""source_assertion"": ""Catalysis 5963 connects native controller Protein/6425 to Reactions/6000. The Rhea reconstruction is grounded separately in UniProt, not a native PathBank Rhea xref."", ""source_locator"": ""#ReactionCatalysis/5963 bp:controller,bp:controlled""}, {""reference_id"": ""UniProtKB:P23883"", ""source_assertion"": ""P23883 CATALYTIC ACTIVITY assigns RHEA:28410; ECO:0000269 supports this catalytic annotation."", ""source_locator"": ""primaryAccession; comments[commentType=CATALYTIC ACTIVITY].reaction[reactionCrossReferences.id=RHEA:28410]; comments[commentType=FUNCTION]""}, {""quote"": ""dehydrogenation of gamma-glutamyl-gamma-aminobutyraldehyde"", ""reference_id"": ""PMID:15590624""}]"	"[{""id"": ""PMID:15590624"", ""source_sha256"": ""e12c1d8a9c6c63a70230c956dc2bd2f2738ee6e535b0d064985a4fedb4582be3"", ""source_version"": ""primary abstract in Europe PMC core response accessed 2026-10-10; DOI 10.1074/jbc.m411114200"", ""title"": ""A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/15590624/""}, {""id"": ""PathBank:SMP0002067"", ""source_sha256"": ""0aa406cfc7c31bc502c695a85a4d1c5b2bf2c8d9d2de4bba6e45195b5a86585e"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002054.owl; accessed 2026-10-10"", ""title"": ""PathBank Putrescine Degradation II native BioPAX pathway"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P23883"", ""source_sha256"": ""35285326eb69ddd878709d5b3e5acca6f650bcb7f2b331907cdfccbb332a816e"", ""source_version"": ""accessed 2026-10-10; entry version 169; sequence version 2"", ""title"": ""Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23883.json""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-027_a6418e46c1fa	PathBank:SMP0002067/ProteinComplex/1396	pathwaymech:catalyzes	RHEA:19738	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:16499623|PathBank:SMP0002067|UniProtKB:P76038	The source-defined PuuD homodimer hydrolyzes the gamma-glutamyl linkage, releasing GABA and L-glutamate; its gene-product node does not imply monomer catalysis.	"[{""reference_id"": ""PathBank:SMP0002067"", ""source_assertion"": ""Catalysis 5964 connects native controller ProteinComplex/1396 to Reactions/6001. The Rhea reconstruction is grounded separately in UniProt, not a native PathBank Rhea xref."", ""source_locator"": ""#ReactionCatalysis/5964 bp:controller,bp:controlled""}, {""reference_id"": ""UniProtKB:P76038"", ""source_assertion"": ""P76038 CATALYTIC ACTIVITY assigns RHEA:19737; ECO:0000269 supports this catalytic annotation."", ""source_locator"": ""primaryAccession; comments[commentType=CATALYTIC ACTIVITY].reaction[reactionCrossReferences.id=RHEA:19737]; comments[commentType=FUNCTION]""}, {""quote"": ""gamma-Glutamyl-gamma-aminobutyrate hydrolase (PuuD) was purified"", ""reference_id"": ""PMID:16499623""}]"	"[{""id"": ""PMID:16499623"", ""source_sha256"": ""e12c1d8a9c6c63a70230c956dc2bd2f2738ee6e535b0d064985a4fedb4582be3"", ""source_version"": ""primary abstract in Europe PMC core response accessed 2026-10-10; DOI 10.1111/j.1574-6968.2006.00137.x"", ""title"": ""Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/16499623/""}, {""id"": ""PathBank:SMP0002067"", ""source_sha256"": ""0aa406cfc7c31bc502c695a85a4d1c5b2bf2c8d9d2de4bba6e45195b5a86585e"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002054.owl; accessed 2026-10-10"", ""title"": ""PathBank Putrescine Degradation II native BioPAX pathway"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P76038"", ""source_sha256"": ""55a8b2680c135baf3d69ce723aa81e71fe9ee5f6d53ac626d0a8fa2c229ae8de"", ""source_version"": ""accessed 2026-10-10; entry version 171; sequence version 2"", ""title"": ""Gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P76038.json""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-028_d38c5073fb68	PathBank:SMP0002067/ProteinComplex/4033	BFO:0000051	UniProtKB:P78061	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002067|UniProtKB:P78061	The native assembly contains 12 copies of this protein; this is assembly stoichiometry, not a reaction coefficient.	"[{""reference_id"": ""PathBank:SMP0002067"", ""source_assertion"": ""ProteinComplex/4033 contains Protein/6804 with componentStoichiometry 12.0; ProteinReference/6804 links UniProt P78061."", ""source_locator"": ""#ProteinComplex/4033 bp:component,bp:componentStoichiometry; #Protein/6804/Stoichiometry/12.0; #ProteinReference/6804 bp:xref""}, {""reference_id"": ""UniProtKB:P78061"", ""source_assertion"": ""SUBUNIT reports Dodecamer (ECO:0000269 PMID18495664)."", ""source_locator"": ""comments[commentType=SUBUNIT].texts""}]"	"[{""id"": ""PathBank:SMP0002067"", ""source_sha256"": ""0aa406cfc7c31bc502c695a85a4d1c5b2bf2c8d9d2de4bba6e45195b5a86585e"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002054.owl; accessed 2026-10-10"", ""title"": ""PathBank Putrescine Degradation II native BioPAX pathway"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P78061"", ""source_sha256"": ""53e5074fa605000a5642112147053c2c5b3c8e4a45fecf8ea7aa18f2ba932c22"", ""source_version"": ""accessed 2026-10-10; entry version 166; sequence version 2"", ""title"": ""Gamma-glutamylputrescine synthetase PuuA — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P78061.json""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-029_77c72ec7a71a	PathBank:SMP0002067/ProteinComplex/1396	BFO:0000051	UniProtKB:P76038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002067|UniProtKB:P76038	The native assembly contains 2 copies of this protein; this is assembly stoichiometry, not a reaction coefficient.	"[{""reference_id"": ""PathBank:SMP0002067"", ""source_assertion"": ""ProteinComplex/1396 contains Protein/6732 with componentStoichiometry 2.0; ProteinReference/6732 links UniProt P76038."", ""source_locator"": ""#ProteinComplex/1396 bp:component,bp:componentStoichiometry; #Protein/6732/Stoichiometry/2.0; #ProteinReference/6732 bp:xref""}, {""reference_id"": ""UniProtKB:P76038"", ""source_assertion"": ""SUBUNIT reports Homodimer (ECO:0000269 PMID16499623)."", ""source_locator"": ""comments[commentType=SUBUNIT].texts""}]"	"[{""id"": ""PathBank:SMP0002067"", ""source_sha256"": ""0aa406cfc7c31bc502c695a85a4d1c5b2bf2c8d9d2de4bba6e45195b5a86585e"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002054.owl; accessed 2026-10-10"", ""title"": ""PathBank Putrescine Degradation II native BioPAX pathway"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P76038"", ""source_sha256"": ""55a8b2680c135baf3d69ce723aa81e71fe9ee5f6d53ac626d0a8fa2c229ae8de"", ""source_version"": ""accessed 2026-10-10; entry version 171; sequence version 2"", ""title"": ""Gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P76038.json""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-030_ed2d0eaa3d82	UniProtKB:P78061	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P78061	Magnesium is the required metal in the inspected UniProt cofactor annotation. Evidence is ECO:0000269 PMID18495664, not inference from ATP assay presence.	"[{""reference_id"": ""UniProtKB:P78061"", ""source_assertion"": ""COFACTOR lists Mg(2+) (CHEBI:18420) with ECO:0000269 PMID18495664; note: Requires Mg(2+), that can be substituted by Mn(2+)."", ""source_locator"": ""comments[commentType=COFACTOR].cofactors; note.texts""}]"	"[{""id"": ""UniProtKB:P78061"", ""source_sha256"": ""53e5074fa605000a5642112147053c2c5b3c8e4a45fecf8ea7aa18f2ba932c22"", ""source_version"": ""accessed 2026-10-10; entry version 166; sequence version 2"", ""title"": ""Gamma-glutamylputrescine synthetase PuuA — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P78061.json""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-031_b548bb4ff80b	UniProtKB:P78061	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P78061	Manganese can substitute for magnesium; the two edges do not require simultaneous occupancy by both metals. Evidence is ECO:0000269 PMID18495664, not inference from ATP assay presence.	"[{""reference_id"": ""UniProtKB:P78061"", ""source_assertion"": ""COFACTOR lists Mn(2+) (CHEBI:29035) with ECO:0000269 PMID18495664; note: Requires Mg(2+), that can be substituted by Mn(2+)."", ""source_locator"": ""comments[commentType=COFACTOR].cofactors; note.texts""}]"	"[{""id"": ""UniProtKB:P78061"", ""source_sha256"": ""53e5074fa605000a5642112147053c2c5b3c8e4a45fecf8ea7aa18f2ba932c22"", ""source_version"": ""accessed 2026-10-10; entry version 166; sequence version 2"", ""title"": ""Gamma-glutamylputrescine synthetase PuuA — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P78061.json""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-032_f9062355dc15	RHEA:13634	BFO:0000050	PathBank:SMP0002067	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002067|UniProtKB:P78061	This is core biochemical step 1/4. Membership is jointly supported by native reaction membership and the independent UniProt step assertion; no native PathBank-to-Rhea xref is claimed.	"[{""reference_id"": ""PathBank:SMP0002067"", ""source_assertion"": ""SMP0002067 pathwayComponent explicitly includes Reactions/5997."", ""source_locator"": ""http://identifiers.org/smpdb/SMP0002067 bp:pathwayComponent""}, {""reference_id"": ""UniProtKB:P78061"", ""source_assertion"": ""PATHWAY: 4-aminobutanoate from putrescine: step 1/4; ECO:0000269 PMID18495664."", ""source_locator"": ""comments[commentType=PATHWAY].texts""}]"	"[{""id"": ""PathBank:SMP0002067"", ""source_sha256"": ""0aa406cfc7c31bc502c695a85a4d1c5b2bf2c8d9d2de4bba6e45195b5a86585e"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002054.owl; accessed 2026-10-10"", ""title"": ""PathBank Putrescine Degradation II native BioPAX pathway"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P78061"", ""source_sha256"": ""53e5074fa605000a5642112147053c2c5b3c8e4a45fecf8ea7aa18f2ba932c22"", ""source_version"": ""accessed 2026-10-10; entry version 166; sequence version 2"", ""title"": ""Gamma-glutamylputrescine synthetase PuuA — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P78061.json""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-033_0785e0e6fe50	RHEA:28415	BFO:0000050	PathBank:SMP0002067	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002067|UniProtKB:P37906	This is core biochemical step 2/4. Membership is jointly supported by native reaction membership and the independent UniProt step assertion; no native PathBank-to-Rhea xref is claimed.	"[{""reference_id"": ""PathBank:SMP0002067"", ""source_assertion"": ""SMP0002067 pathwayComponent explicitly includes Reactions/5998."", ""source_locator"": ""http://identifiers.org/smpdb/SMP0002067 bp:pathwayComponent""}, {""reference_id"": ""UniProtKB:P37906"", ""source_assertion"": ""PATHWAY: 4-aminobutanoate from putrescine: step 2/4; no explicit evidence code."", ""source_locator"": ""comments[commentType=PATHWAY].texts""}]"	"[{""id"": ""PathBank:SMP0002067"", ""source_sha256"": ""0aa406cfc7c31bc502c695a85a4d1c5b2bf2c8d9d2de4bba6e45195b5a86585e"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002054.owl; accessed 2026-10-10"", ""title"": ""PathBank Putrescine Degradation II native BioPAX pathway"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P37906"", ""source_sha256"": ""e2c52cd03cf231f49551c23173acd8ce5b5c4782cdeb7917428146506c65ba25"", ""source_version"": ""accessed 2026-10-10; entry version 163; sequence version 2"", ""title"": ""Gamma-glutamylputrescine oxidoreductase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37906.json""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-034_8b48c911dd53	RHEA:28411	BFO:0000050	PathBank:SMP0002067	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002067|UniProtKB:P23883	This is core biochemical step 3/4. Membership is jointly supported by native reaction membership and the independent UniProt step assertion; no native PathBank-to-Rhea xref is claimed.	"[{""reference_id"": ""PathBank:SMP0002067"", ""source_assertion"": ""SMP0002067 pathwayComponent explicitly includes Reactions/6000."", ""source_locator"": ""http://identifiers.org/smpdb/SMP0002067 bp:pathwayComponent""}, {""reference_id"": ""UniProtKB:P23883"", ""source_assertion"": ""PATHWAY: 4-aminobutanoate from putrescine: step 3/4; ECO:0000269 PMID22636776 and ECO:0000305 PMID15590624."", ""source_locator"": ""comments[commentType=PATHWAY].texts""}]"	"[{""id"": ""PathBank:SMP0002067"", ""source_sha256"": ""0aa406cfc7c31bc502c695a85a4d1c5b2bf2c8d9d2de4bba6e45195b5a86585e"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002054.owl; accessed 2026-10-10"", ""title"": ""PathBank Putrescine Degradation II native BioPAX pathway"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P23883"", ""source_sha256"": ""35285326eb69ddd878709d5b3e5acca6f650bcb7f2b331907cdfccbb332a816e"", ""source_version"": ""accessed 2026-10-10; entry version 169; sequence version 2"", ""title"": ""Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23883.json""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-035_c6b966bf40f1	RHEA:19738	BFO:0000050	PathBank:SMP0002067	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002067|UniProtKB:P76038	This is core biochemical step 4/4. Membership is jointly supported by native reaction membership and the independent UniProt step assertion; no native PathBank-to-Rhea xref is claimed.	"[{""reference_id"": ""PathBank:SMP0002067"", ""source_assertion"": ""SMP0002067 pathwayComponent explicitly includes Reactions/6001."", ""source_locator"": ""http://identifiers.org/smpdb/SMP0002067 bp:pathwayComponent""}, {""reference_id"": ""UniProtKB:P76038"", ""source_assertion"": ""PATHWAY: 4-aminobutanoate from putrescine: step 4/4; no explicit evidence code."", ""source_locator"": ""comments[commentType=PATHWAY].texts""}]"	"[{""id"": ""PathBank:SMP0002067"", ""source_sha256"": ""0aa406cfc7c31bc502c695a85a4d1c5b2bf2c8d9d2de4bba6e45195b5a86585e"", ""source_version"": ""primary archive Last-Modified 2019-08-16; member PW002054.owl; accessed 2026-10-10"", ""title"": ""PathBank Putrescine Degradation II native BioPAX pathway"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P76038"", ""source_sha256"": ""55a8b2680c135baf3d69ce723aa81e71fe9ee5f6d53ac626d0a8fa2c229ae8de"", ""source_version"": ""accessed 2026-10-10; entry version 171; sequence version 2"", ""title"": ""Gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P76038.json""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-036_5d82e9712835	RHEA:13634	RO:0002413	RHEA:28415	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13633|RHEA:28414	Direct material connection through gamma-L-glutamylputrescinium(1+). This is a chemical sequence, not regulatory activation.	"[{""reference_id"": ""RHEA:13633"", ""source_assertion"": ""RHEA:13634 produces CHEBI:58731, the material passed to the following step."", ""source_locator"": ""http://rdf.rhea-db.org/13634 rh:products; side rh:contains1/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:28414"", ""source_assertion"": ""RHEA:28415 consumes CHEBI:58731, the same chemical form produced by the preceding step."", ""source_locator"": ""http://rdf.rhea-db.org/28415 rh:substrates; side rh:contains1/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13633"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:13633 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/13633""}, {""id"": ""RHEA:28414"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:28414 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/28414""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-037_d124f48f0c8d	RHEA:28415	RO:0002413	RHEA:28411	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28410|RHEA:28414	Direct material connection through gamma-glutamyl-gamma-aminobutyraldehyde zwitterion. This is a chemical sequence, not regulatory activation.	"[{""reference_id"": ""RHEA:28414"", ""source_assertion"": ""RHEA:28415 produces CHEBI:61508, the material passed to the following step."", ""source_locator"": ""http://rdf.rhea-db.org/28415 rh:products; side rh:contains1/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:28410"", ""source_assertion"": ""RHEA:28411 consumes CHEBI:61508, the same chemical form produced by the preceding step."", ""source_locator"": ""http://rdf.rhea-db.org/28411 rh:substrates; side rh:contains1/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28410"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:28410 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/28410""}, {""id"": ""RHEA:28414"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:28414 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/28414""}]"	""
pathwaymech:PathBank_SMP0002067_putrescine-edge-038_3e8ea1f78ec3	RHEA:28411	RO:0002413	RHEA:19738	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19737|RHEA:28410	Direct material connection through 4-(L-gamma-glutamylamino)butanoate. This is a chemical sequence, not regulatory activation.	"[{""reference_id"": ""RHEA:28410"", ""source_assertion"": ""RHEA:28411 produces CHEBI:58800, the material passed to the following step."", ""source_locator"": ""http://rdf.rhea-db.org/28411 rh:products; side rh:contains1/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:19737"", ""source_assertion"": ""RHEA:19738 consumes CHEBI:58800, the same chemical form produced by the preceding step."", ""source_locator"": ""http://rdf.rhea-db.org/19738 rh:substrates; side rh:contains1/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:19737"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:19737 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/19737""}, {""id"": ""RHEA:28410"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; assertions inspected in official rhea.rdf.gz; digest covers complete compressed RDF, not the individual webpage"", ""title"": ""Rhea master RHEA:28410 and its selected catabolic direction"", ""url"": ""https://www.rhea-db.org/rhea/28410""}]"	""
pathwaymech:GO_0042864_pch-edge-001_f62e98a96552	CHEBI:15378	pathwaymech:consumes	MetaCyc:RXN-11113	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-11113		"[{""reference_id"": ""MetaCyc:RXN-11113"", ""source_assertion"": ""The native left side explicitly contains PROTON with coefficient 1; direction is LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11113\""]/left[*/@frameid=\""PROTON\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The original PROTON structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:15378."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""PROTON\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""CHEBI:15378 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:15378; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:15378 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PROTON original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}, {""id"": ""MetaCyc:RXN-11113"", ""source_sha256"": ""71773aac1fddaeb718877d7fa918971ef6933a19317443f1759c2b70e54fc087"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11113 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11113""}]"	""
pathwaymech:GO_0042864_pch-edge-002_b2367332ccd0	CHEBI:30762	pathwaymech:consumes	MetaCyc:RXN-11113	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30762|MetaCyc:CPD-110|MetaCyc:RXN-11113		"[{""reference_id"": ""MetaCyc:RXN-11113"", ""source_assertion"": ""The native left side explicitly contains CPD-110 with coefficient 1; direction is LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11113\""]/left[*/@frameid=\""CPD-110\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-110"", ""source_assertion"": ""The original CPD-110 structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:30762."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""CPD-110\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:30762"", ""source_assertion"": ""CHEBI:30762 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:30762; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:30762"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:30762 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:CPD-110"", ""source_sha256"": ""bba9773d2f06f8db8d42bb17e69149ccf24dc2fed16c2fe544f3284277bb0128"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc CPD-110 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-110""}, {""id"": ""MetaCyc:RXN-11113"", ""source_sha256"": ""71773aac1fddaeb718877d7fa918971ef6933a19317443f1759c2b70e54fc087"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11113 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11113""}]"	""
pathwaymech:GO_0042864_pch-edge-003_807131c015ec	CHEBI:30616	pathwaymech:consumes	MetaCyc:RXN-11113	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:ATP|MetaCyc:RXN-11113		"[{""reference_id"": ""MetaCyc:RXN-11113"", ""source_assertion"": ""The native left side explicitly contains ATP with coefficient 1; direction is LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11113\""]/left[*/@frameid=\""ATP\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:ATP"", ""source_assertion"": ""The original ATP structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:30616."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""ATP\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:30616 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:30616; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:30616 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:ATP"", ""source_sha256"": ""bb03bc7d49a62af159cb0563a5b5a58e655787bb44290cf682b4a723a2d93f50"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc ATP original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ATP""}, {""id"": ""MetaCyc:RXN-11113"", ""source_sha256"": ""71773aac1fddaeb718877d7fa918971ef6933a19317443f1759c2b70e54fc087"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11113 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11113""}]"	""
pathwaymech:GO_0042864_pch-edge-004_d760fcc86e03	MetaCyc:RXN-11113	pathwaymech:produces	CHEBI:86458	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:86458|MetaCyc:CPD-12084|MetaCyc:RXN-11113		"[{""reference_id"": ""MetaCyc:RXN-11113"", ""source_assertion"": ""The native right side explicitly contains CPD-12084 with coefficient 1; direction is LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11113\""]/right[*/@frameid=\""CPD-12084\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-12084"", ""source_assertion"": ""The original CPD-12084 structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:86458."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""CPD-12084\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:86458"", ""source_assertion"": ""CHEBI:86458 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:86458; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:86458"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:86458 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:CPD-12084"", ""source_sha256"": ""eab3b0c27eca19f6f4bceab5df5ebe1f6ff722dd2e783d0df396dd0c82fce946"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc CPD-12084 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-12084""}, {""id"": ""MetaCyc:RXN-11113"", ""source_sha256"": ""71773aac1fddaeb718877d7fa918971ef6933a19317443f1759c2b70e54fc087"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11113 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11113""}]"	""
pathwaymech:GO_0042864_pch-edge-005_1a62a9834f80	MetaCyc:RXN-11113	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:33019|MetaCyc:PPI|MetaCyc:RXN-11113		"[{""reference_id"": ""MetaCyc:RXN-11113"", ""source_assertion"": ""The native right side explicitly contains PPI with coefficient 1; direction is LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11113\""]/right[*/@frameid=\""PPI\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:PPI"", ""source_assertion"": ""The original PPI structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:33019."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""PPI\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:33019"", ""source_assertion"": ""CHEBI:33019 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:33019; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:33019"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:33019 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:PPI"", ""source_sha256"": ""9e6257dbc2e18b5c475d4a546eef842e55dd1432dbdada4d0a88d22c381aede9"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PPI original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PPI""}, {""id"": ""MetaCyc:RXN-11113"", ""source_sha256"": ""71773aac1fddaeb718877d7fa918971ef6933a19317443f1759c2b70e54fc087"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11113 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11113""}]"	""
pathwaymech:GO_0042864_pch-edge-006_8e77f3232dc9	CHEBI:35235	pathwaymech:consumes	MetaCyc:RXN-11115	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:35235|MetaCyc:CYS|MetaCyc:RXN-11115		"[{""reference_id"": ""MetaCyc:RXN-11115"", ""source_assertion"": ""The native left side explicitly contains CYS with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11115\""]/left[*/@frameid=\""CYS\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:CYS"", ""source_assertion"": ""The original CYS structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:35235."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""CYS\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:35235"", ""source_assertion"": ""CHEBI:35235 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:35235; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:35235"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:35235 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:CYS"", ""source_sha256"": ""2efb761a8f3dda7b9ea14957def20f28c1b478037ee94cdda7bb2148c37b3bdd"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc CYS original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYS""}, {""id"": ""MetaCyc:RXN-11115"", ""source_sha256"": ""0c41201a721f9458ccb3108759e8756b0584a62b1f7ccea6799e2e3c24105164"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11115 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11115""}]"	""
pathwaymech:GO_0042864_pch-edge-007_6bdbe66b7ef2	CHEBI:30616	pathwaymech:consumes	MetaCyc:RXN-11115	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:30616|MetaCyc:ATP|MetaCyc:RXN-11115		"[{""reference_id"": ""MetaCyc:RXN-11115"", ""source_assertion"": ""The native left side explicitly contains ATP with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11115\""]/left[*/@frameid=\""ATP\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:ATP"", ""source_assertion"": ""The original ATP structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:30616."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""ATP\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:30616"", ""source_assertion"": ""CHEBI:30616 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:30616; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:30616"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:30616 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:ATP"", ""source_sha256"": ""bb03bc7d49a62af159cb0563a5b5a58e655787bb44290cf682b4a723a2d93f50"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc ATP original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ATP""}, {""id"": ""MetaCyc:RXN-11115"", ""source_sha256"": ""0c41201a721f9458ccb3108759e8756b0584a62b1f7ccea6799e2e3c24105164"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11115 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11115""}]"	""
pathwaymech:GO_0042864_pch-edge-008_f751cc4d4baf	CHEBI:15378	pathwaymech:consumes	MetaCyc:RXN-11115	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-11115		"[{""reference_id"": ""MetaCyc:RXN-11115"", ""source_assertion"": ""The native left side explicitly contains PROTON with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11115\""]/left[*/@frameid=\""PROTON\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The original PROTON structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:15378."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""PROTON\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""CHEBI:15378 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:15378; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:15378 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PROTON original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}, {""id"": ""MetaCyc:RXN-11115"", ""source_sha256"": ""0c41201a721f9458ccb3108759e8756b0584a62b1f7ccea6799e2e3c24105164"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11115 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11115""}]"	""
pathwaymech:GO_0042864_pch-edge-009_27a3aeab4e08	MetaCyc:RXN-11115	pathwaymech:produces	CHEBI:144924	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:144924|MetaCyc:CPD-12085|MetaCyc:RXN-11115		"[{""reference_id"": ""MetaCyc:RXN-11115"", ""source_assertion"": ""The native right side explicitly contains CPD-12085 with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11115\""]/right[*/@frameid=\""CPD-12085\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-12085"", ""source_assertion"": ""The original CPD-12085 structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:144924."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""CPD-12085\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:144924"", ""source_assertion"": ""CHEBI:144924 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:144924; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:144924"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:144924 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:CPD-12085"", ""source_sha256"": ""af840f13b48542de5820b3b3c8b9fc605b4ef1a7c94eab2fe4c868f8947637f2"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc CPD-12085 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-12085""}, {""id"": ""MetaCyc:RXN-11115"", ""source_sha256"": ""0c41201a721f9458ccb3108759e8756b0584a62b1f7ccea6799e2e3c24105164"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11115 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11115""}]"	""
pathwaymech:GO_0042864_pch-edge-010_2bf8d4babd0d	MetaCyc:RXN-11115	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:33019|MetaCyc:PPI|MetaCyc:RXN-11115		"[{""reference_id"": ""MetaCyc:RXN-11115"", ""source_assertion"": ""The native right side explicitly contains PPI with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11115\""]/right[*/@frameid=\""PPI\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:PPI"", ""source_assertion"": ""The original PPI structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:33019."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""PPI\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:33019"", ""source_assertion"": ""CHEBI:33019 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:33019; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:33019"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:33019 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:PPI"", ""source_sha256"": ""9e6257dbc2e18b5c475d4a546eef842e55dd1432dbdada4d0a88d22c381aede9"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PPI original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PPI""}, {""id"": ""MetaCyc:RXN-11115"", ""source_sha256"": ""0c41201a721f9458ccb3108759e8756b0584a62b1f7ccea6799e2e3c24105164"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11115 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11115""}]"	""
pathwaymech:GO_0042864_pch-edge-011_b2492afdb500	CHEBI:144924	pathwaymech:consumes	MetaCyc:RXN-11117	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:144924|MetaCyc:CPD-12085|MetaCyc:RXN-11117		"[{""reference_id"": ""MetaCyc:RXN-11117"", ""source_assertion"": ""The native left side explicitly contains CPD-12085 with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11117\""]/left[*/@frameid=\""CPD-12085\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-12085"", ""source_assertion"": ""The original CPD-12085 structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:144924."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""CPD-12085\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:144924"", ""source_assertion"": ""CHEBI:144924 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:144924; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:144924"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:144924 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:CPD-12085"", ""source_sha256"": ""af840f13b48542de5820b3b3c8b9fc605b4ef1a7c94eab2fe4c868f8947637f2"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc CPD-12085 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-12085""}, {""id"": ""MetaCyc:RXN-11117"", ""source_sha256"": ""397e1a01575feef9f7d0e3743d9e7fd08c6acec629cb1a16bc697cedfd846548"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11117 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11117""}]"	""
pathwaymech:GO_0042864_pch-edge-012_08d08855641f	MetaCyc:PchF	pathwaymech:consumes	MetaCyc:RXN-11117	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:PchF|MetaCyc:RXN-11117	Native PchF reactive-domain state; coefficient is not an enzyme assembly count.	"[{""reference_id"": ""MetaCyc:RXN-11117"", ""source_assertion"": ""The native left side explicitly contains PchF with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11117\""]/left[*/@frameid=\""PchF\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:PchF"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""PchF\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:PchF"", ""source_sha256"": ""e766f5cdf7c4e69939897db9b2eb30fbe335c8b1ca94933ac2598c5826a12180"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PchF original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PchF""}, {""id"": ""MetaCyc:RXN-11117"", ""source_sha256"": ""397e1a01575feef9f7d0e3743d9e7fd08c6acec629cb1a16bc697cedfd846548"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11117 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11117""}]"	""
pathwaymech:GO_0042864_pch-edge-013_04a446caff34	MetaCyc:RXN-11117	pathwaymech:produces	MetaCyc:L-cysteinyl-PchF	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:L-cysteinyl-PchF|MetaCyc:RXN-11117	Native PchF reactive-domain state; coefficient is not an enzyme assembly count.	"[{""reference_id"": ""MetaCyc:RXN-11117"", ""source_assertion"": ""The native right side explicitly contains L-cysteinyl-PchF with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11117\""]/right[*/@frameid=\""L-cysteinyl-PchF\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:L-cysteinyl-PchF"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""L-cysteinyl-PchF\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:L-cysteinyl-PchF"", ""source_sha256"": ""68c2cce691d2620dd8fa1d55c2cfd8f76aa56f0c1232a7649400920e1e938021"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc L-cysteinyl-PchF original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:L-cysteinyl-PchF""}, {""id"": ""MetaCyc:RXN-11117"", ""source_sha256"": ""397e1a01575feef9f7d0e3743d9e7fd08c6acec629cb1a16bc697cedfd846548"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11117 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11117""}]"	""
pathwaymech:GO_0042864_pch-edge-014_e94eda64bda6	MetaCyc:RXN-11117	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:456215|MetaCyc:AMP|MetaCyc:RXN-11117		"[{""reference_id"": ""MetaCyc:RXN-11117"", ""source_assertion"": ""The native right side explicitly contains AMP with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11117\""]/right[*/@frameid=\""AMP\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:AMP"", ""source_assertion"": ""The original AMP structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:456215."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""AMP\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:456215"", ""source_assertion"": ""CHEBI:456215 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:456215; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:456215"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:456215 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:AMP"", ""source_sha256"": ""f4de874fe3fd147827332ac5f9544e83b533d99e1141ba599a73ac9853f65a62"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc AMP original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:AMP""}, {""id"": ""MetaCyc:RXN-11117"", ""source_sha256"": ""397e1a01575feef9f7d0e3743d9e7fd08c6acec629cb1a16bc697cedfd846548"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11117 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11117""}]"	""
pathwaymech:GO_0042864_pch-edge-015_d2680de16bee	MetaCyc:RXN-11117	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-11117		"[{""reference_id"": ""MetaCyc:RXN-11117"", ""source_assertion"": ""The native right side explicitly contains PROTON with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11117\""]/right[*/@frameid=\""PROTON\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The original PROTON structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:15378."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""PROTON\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""CHEBI:15378 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:15378; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:15378 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PROTON original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}, {""id"": ""MetaCyc:RXN-11117"", ""source_sha256"": ""397e1a01575feef9f7d0e3743d9e7fd08c6acec629cb1a16bc697cedfd846548"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11117 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11117""}]"	""
pathwaymech:GO_0042864_pch-edge-016_f06f9e9eb06c	MetaCyc:Salicyl-L-cysteinyl-PchE	pathwaymech:consumes	MetaCyc:RXN-11118	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:RXN-11118|MetaCyc:Salicyl-L-cysteinyl-PchE	Native reactive-domain class; PchE aryl and peptidyl sites are separate reaction sites on the same polypeptide.	"[{""reference_id"": ""MetaCyc:RXN-11118"", ""source_assertion"": ""The native left side explicitly contains Salicyl-L-cysteinyl-PchE with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11118\""]/left[*/@frameid=\""Salicyl-L-cysteinyl-PchE\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:Salicyl-L-cysteinyl-PchE"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""Salicyl-L-cysteinyl-PchE\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:RXN-11118"", ""source_sha256"": ""ed597e122d42856b809477bbbece65a904af1b39677b1a5193834347c8b184c6"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11118 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11118""}, {""id"": ""MetaCyc:Salicyl-L-cysteinyl-PchE"", ""source_sha256"": ""d6c791d2e6632f200e7d187c011f249ec216a446c3ceb3071e70aa37b0343f0e"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc Salicyl-L-cysteinyl-PchE original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Salicyl-L-cysteinyl-PchE""}]"	""
pathwaymech:GO_0042864_pch-edge-017_e323c35525c3	MetaCyc:RXN-11118	pathwaymech:produces	MetaCyc:hydroxyphenyl-thiazolinyl-PchE	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:RXN-11118|MetaCyc:hydroxyphenyl-thiazolinyl-PchE	Native reactive-domain class; PchE aryl and peptidyl sites are separate reaction sites on the same polypeptide.	"[{""reference_id"": ""MetaCyc:RXN-11118"", ""source_assertion"": ""The native right side explicitly contains hydroxyphenyl-thiazolinyl-PchE with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11118\""]/right[*/@frameid=\""hydroxyphenyl-thiazolinyl-PchE\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:hydroxyphenyl-thiazolinyl-PchE"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""hydroxyphenyl-thiazolinyl-PchE\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:RXN-11118"", ""source_sha256"": ""ed597e122d42856b809477bbbece65a904af1b39677b1a5193834347c8b184c6"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11118 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11118""}, {""id"": ""MetaCyc:hydroxyphenyl-thiazolinyl-PchE"", ""source_sha256"": ""11e0fdbe012088bb26c2087e593a00d5418c74bd0ce1050de69ec5b5c5f8f887"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc hydroxyphenyl-thiazolinyl-PchE original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:hydroxyphenyl-thiazolinyl-PchE""}]"	""
pathwaymech:GO_0042864_pch-edge-018_31479955171d	MetaCyc:RXN-11118	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15377|MetaCyc:RXN-11118|MetaCyc:WATER		"[{""reference_id"": ""MetaCyc:RXN-11118"", ""source_assertion"": ""The native right side explicitly contains WATER with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11118\""]/right[*/@frameid=\""WATER\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:WATER"", ""source_assertion"": ""The original WATER structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:15377."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""WATER\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:15377"", ""source_assertion"": ""CHEBI:15377 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:15377; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:15377"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:15377 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:RXN-11118"", ""source_sha256"": ""ed597e122d42856b809477bbbece65a904af1b39677b1a5193834347c8b184c6"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11118 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11118""}, {""id"": ""MetaCyc:WATER"", ""source_sha256"": ""47621552fb854daf04df0375c4540b0f42103652ec2d2a5f384ad06dead702e3"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc WATER original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:WATER""}]"	""
pathwaymech:GO_0042864_pch-edge-019_3c62e350f3ae	MetaCyc:L-cysteinyl-PchF	pathwaymech:consumes	MetaCyc:RXN-11120	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:L-cysteinyl-PchF|MetaCyc:RXN-11120	Native PchF reactive-domain state; coefficient is not an enzyme assembly count.	"[{""reference_id"": ""MetaCyc:RXN-11120"", ""source_assertion"": ""The native left side explicitly contains L-cysteinyl-PchF with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11120\""]/left[*/@frameid=\""L-cysteinyl-PchF\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:L-cysteinyl-PchF"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""L-cysteinyl-PchF\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:L-cysteinyl-PchF"", ""source_sha256"": ""68c2cce691d2620dd8fa1d55c2cfd8f76aa56f0c1232a7649400920e1e938021"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc L-cysteinyl-PchF original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:L-cysteinyl-PchF""}, {""id"": ""MetaCyc:RXN-11120"", ""source_sha256"": ""46561ff8f4705b28853f5720c5d18d0d3088de9767a169a25bef7324567bb3c4"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11120 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11120""}]"	""
pathwaymech:GO_0042864_pch-edge-020_b6f9c6a0beac	MetaCyc:hydroxyphenyl-thiazolinyl-PchE	pathwaymech:consumes	MetaCyc:RXN-11120	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:RXN-11120|MetaCyc:hydroxyphenyl-thiazolinyl-PchE	Native reactive-domain class; PchE aryl and peptidyl sites are separate reaction sites on the same polypeptide.	"[{""reference_id"": ""MetaCyc:RXN-11120"", ""source_assertion"": ""The native left side explicitly contains hydroxyphenyl-thiazolinyl-PchE with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11120\""]/left[*/@frameid=\""hydroxyphenyl-thiazolinyl-PchE\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:hydroxyphenyl-thiazolinyl-PchE"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""hydroxyphenyl-thiazolinyl-PchE\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:RXN-11120"", ""source_sha256"": ""46561ff8f4705b28853f5720c5d18d0d3088de9767a169a25bef7324567bb3c4"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11120 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11120""}, {""id"": ""MetaCyc:hydroxyphenyl-thiazolinyl-PchE"", ""source_sha256"": ""11e0fdbe012088bb26c2087e593a00d5418c74bd0ce1050de69ec5b5c5f8f887"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc hydroxyphenyl-thiazolinyl-PchE original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:hydroxyphenyl-thiazolinyl-PchE""}]"	""
pathwaymech:GO_0042864_pch-edge-021_4ee8b7d0e457	MetaCyc:RXN-11120	pathwaymech:produces	MetaCyc:Hydroxyphenyl-bis-thiazolinyl-PchF	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:Hydroxyphenyl-bis-thiazolinyl-PchF|MetaCyc:RXN-11120	Native PchF reactive-domain state; coefficient is not an enzyme assembly count.	"[{""reference_id"": ""MetaCyc:RXN-11120"", ""source_assertion"": ""The native right side explicitly contains Hydroxyphenyl-bis-thiazolinyl-PchF with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11120\""]/right[*/@frameid=\""Hydroxyphenyl-bis-thiazolinyl-PchF\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:Hydroxyphenyl-bis-thiazolinyl-PchF"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""Hydroxyphenyl-bis-thiazolinyl-PchF\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:Hydroxyphenyl-bis-thiazolinyl-PchF"", ""source_sha256"": ""35eb2420cf0f5c35c53297bb5c994e5eb3307ff32ff95b3dab4e4429a98ca523"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc Hydroxyphenyl-bis-thiazolinyl-PchF original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Hydroxyphenyl-bis-thiazolinyl-PchF""}, {""id"": ""MetaCyc:RXN-11120"", ""source_sha256"": ""46561ff8f4705b28853f5720c5d18d0d3088de9767a169a25bef7324567bb3c4"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11120 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11120""}]"	""
pathwaymech:GO_0042864_pch-edge-022_f935931f9642	MetaCyc:RXN-11120	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15377|MetaCyc:RXN-11120|MetaCyc:WATER		"[{""reference_id"": ""MetaCyc:RXN-11120"", ""source_assertion"": ""The native right side explicitly contains WATER with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11120\""]/right[*/@frameid=\""WATER\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:WATER"", ""source_assertion"": ""The original WATER structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:15377."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""WATER\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:15377"", ""source_assertion"": ""CHEBI:15377 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:15377; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:15377"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:15377 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:RXN-11120"", ""source_sha256"": ""46561ff8f4705b28853f5720c5d18d0d3088de9767a169a25bef7324567bb3c4"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11120 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11120""}, {""id"": ""MetaCyc:WATER"", ""source_sha256"": ""47621552fb854daf04df0375c4540b0f42103652ec2d2a5f384ad06dead702e3"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc WATER original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:WATER""}]"	""
pathwaymech:GO_0042864_pch-edge-023_eb469b5881d9	MetaCyc:RXN-11120	pathwaymech:produces	MetaCyc:PchE	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:PchE|MetaCyc:RXN-11120	Native reactive-domain class; PchE aryl and peptidyl sites are separate reaction sites on the same polypeptide.	"[{""reference_id"": ""MetaCyc:RXN-11120"", ""source_assertion"": ""The native right side explicitly contains PchE with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11120\""]/right[*/@frameid=\""PchE\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:PchE"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""PchE\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:PchE"", ""source_sha256"": ""bfdebcfb211b197b193b45e0532c0e465d09398470ddf2085ccdfa6096926b48"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PchE original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PchE""}, {""id"": ""MetaCyc:RXN-11120"", ""source_sha256"": ""46561ff8f4705b28853f5720c5d18d0d3088de9767a169a25bef7324567bb3c4"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11120 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11120""}]"	""
pathwaymech:GO_0042864_pch-edge-024_0e2584e3a202	MetaCyc:RXN-11120	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-11120		"[{""reference_id"": ""MetaCyc:RXN-11120"", ""source_assertion"": ""The native right side explicitly contains PROTON with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11120\""]/right[*/@frameid=\""PROTON\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The original PROTON structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:15378."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""PROTON\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""CHEBI:15378 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:15378; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:15378 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PROTON original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}, {""id"": ""MetaCyc:RXN-11120"", ""source_sha256"": ""46561ff8f4705b28853f5720c5d18d0d3088de9767a169a25bef7324567bb3c4"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11120 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11120""}]"	""
pathwaymech:GO_0042864_pch-edge-025_5720537b9338	MetaCyc:Hydroxyphenyl-bis-thiazolinyl-PchF	pathwaymech:consumes	MetaCyc:RXN-11121	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:Hydroxyphenyl-bis-thiazolinyl-PchF|MetaCyc:RXN-11121	Native PchF reactive-domain state; coefficient is not an enzyme assembly count.	"[{""reference_id"": ""MetaCyc:RXN-11121"", ""source_assertion"": ""The native left side explicitly contains Hydroxyphenyl-bis-thiazolinyl-PchF with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11121\""]/left[*/@frameid=\""Hydroxyphenyl-bis-thiazolinyl-PchF\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:Hydroxyphenyl-bis-thiazolinyl-PchF"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""Hydroxyphenyl-bis-thiazolinyl-PchF\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:Hydroxyphenyl-bis-thiazolinyl-PchF"", ""source_sha256"": ""35eb2420cf0f5c35c53297bb5c994e5eb3307ff32ff95b3dab4e4429a98ca523"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc Hydroxyphenyl-bis-thiazolinyl-PchF original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Hydroxyphenyl-bis-thiazolinyl-PchF""}, {""id"": ""MetaCyc:RXN-11121"", ""source_sha256"": ""62bc4169f543309b8fa0b35885fb5158e0203e356c72cc75f86a62d5c4dcfd44"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11121 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11121""}]"	""
pathwaymech:GO_0042864_pch-edge-026_db4fef823e2f	CHEBI:57783	pathwaymech:consumes	MetaCyc:RXN-11121	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:57783|MetaCyc:NADPH|MetaCyc:RXN-11121		"[{""reference_id"": ""MetaCyc:RXN-11121"", ""source_assertion"": ""The native left side explicitly contains NADPH with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11121\""]/left[*/@frameid=\""NADPH\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:NADPH"", ""source_assertion"": ""The original NADPH structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:57783."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""NADPH\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:57783"", ""source_assertion"": ""CHEBI:57783 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:57783; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:57783"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:57783 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:NADPH"", ""source_sha256"": ""f84b2ec1facffc897e2ec4fec79f984c67a8d57e22192585f85188e88350aaea"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc NADPH original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:NADPH""}, {""id"": ""MetaCyc:RXN-11121"", ""source_sha256"": ""62bc4169f543309b8fa0b35885fb5158e0203e356c72cc75f86a62d5c4dcfd44"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11121 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11121""}]"	""
pathwaymech:GO_0042864_pch-edge-027_3bafebe57b64	CHEBI:15378	pathwaymech:consumes	MetaCyc:RXN-11121	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-11121		"[{""reference_id"": ""MetaCyc:RXN-11121"", ""source_assertion"": ""The native left side explicitly contains PROTON with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11121\""]/left[*/@frameid=\""PROTON\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The original PROTON structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:15378."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""PROTON\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""CHEBI:15378 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:15378; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:15378 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PROTON original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}, {""id"": ""MetaCyc:RXN-11121"", ""source_sha256"": ""62bc4169f543309b8fa0b35885fb5158e0203e356c72cc75f86a62d5c4dcfd44"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11121 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11121""}]"	""
pathwaymech:GO_0042864_pch-edge-028_3cbcbf2f7007	MetaCyc:RXN-11121	pathwaymech:produces	MetaCyc:N-desmethyl-pyochelin-PchF	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:N-desmethyl-pyochelin-PchF|MetaCyc:RXN-11121	Native PchF reactive-domain state; coefficient is not an enzyme assembly count.	"[{""reference_id"": ""MetaCyc:RXN-11121"", ""source_assertion"": ""The native right side explicitly contains N-desmethyl-pyochelin-PchF with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11121\""]/right[*/@frameid=\""N-desmethyl-pyochelin-PchF\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:N-desmethyl-pyochelin-PchF"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""N-desmethyl-pyochelin-PchF\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:N-desmethyl-pyochelin-PchF"", ""source_sha256"": ""623f334c2348fde749bf140807a1441beb3f64df38358f205496f6a0d90f2a4a"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc N-desmethyl-pyochelin-PchF original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:N-desmethyl-pyochelin-PchF""}, {""id"": ""MetaCyc:RXN-11121"", ""source_sha256"": ""62bc4169f543309b8fa0b35885fb5158e0203e356c72cc75f86a62d5c4dcfd44"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11121 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11121""}]"	""
pathwaymech:GO_0042864_pch-edge-029_2fb37344e002	MetaCyc:RXN-11121	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:58349|MetaCyc:NADP|MetaCyc:RXN-11121		"[{""reference_id"": ""MetaCyc:RXN-11121"", ""source_assertion"": ""The native right side explicitly contains NADP with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11121\""]/right[*/@frameid=\""NADP\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:NADP"", ""source_assertion"": ""The original NADP structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:58349."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""NADP\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:58349"", ""source_assertion"": ""CHEBI:58349 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:58349; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:58349"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:58349 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:NADP"", ""source_sha256"": ""92bd2db99b138628b27557c6ad2f7e0f85d6750517be479b8de9047a1c03f2ea"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc NADP original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:NADP""}, {""id"": ""MetaCyc:RXN-11121"", ""source_sha256"": ""62bc4169f543309b8fa0b35885fb5158e0203e356c72cc75f86a62d5c4dcfd44"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11121 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11121""}]"	""
pathwaymech:GO_0042864_pch-edge-030_93c4454d8adf	CHEBI:59789	pathwaymech:consumes	MetaCyc:RXN-11122	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:59789|MetaCyc:RXN-11122|MetaCyc:S-ADENOSYLMETHIONINE		"[{""reference_id"": ""MetaCyc:RXN-11122"", ""source_assertion"": ""The native left side explicitly contains S-ADENOSYLMETHIONINE with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11122\""]/left[*/@frameid=\""S-ADENOSYLMETHIONINE\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:S-ADENOSYLMETHIONINE"", ""source_assertion"": ""The original S-ADENOSYLMETHIONINE structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:59789."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""S-ADENOSYLMETHIONINE\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:59789"", ""source_assertion"": ""CHEBI:59789 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:59789; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:59789"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:59789 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:RXN-11122"", ""source_sha256"": ""b6ac9eef8c0f9508fc844fc55516dbdf105599fcbe3a51821c25c5f08774af9f"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11122 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11122""}, {""id"": ""MetaCyc:S-ADENOSYLMETHIONINE"", ""source_sha256"": ""1f1a6d61f3e5156bf82f8f0f0b2395c691808db85764e0c0e44d75cf99fe0b3b"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc S-ADENOSYLMETHIONINE original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:S-ADENOSYLMETHIONINE""}]"	""
pathwaymech:GO_0042864_pch-edge-031_9af72a786fc0	MetaCyc:N-desmethyl-pyochelin-PchF	pathwaymech:consumes	MetaCyc:RXN-11122	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:N-desmethyl-pyochelin-PchF|MetaCyc:RXN-11122	Native PchF reactive-domain state; coefficient is not an enzyme assembly count.	"[{""reference_id"": ""MetaCyc:RXN-11122"", ""source_assertion"": ""The native left side explicitly contains N-desmethyl-pyochelin-PchF with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11122\""]/left[*/@frameid=\""N-desmethyl-pyochelin-PchF\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:N-desmethyl-pyochelin-PchF"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""N-desmethyl-pyochelin-PchF\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:N-desmethyl-pyochelin-PchF"", ""source_sha256"": ""623f334c2348fde749bf140807a1441beb3f64df38358f205496f6a0d90f2a4a"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc N-desmethyl-pyochelin-PchF original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:N-desmethyl-pyochelin-PchF""}, {""id"": ""MetaCyc:RXN-11122"", ""source_sha256"": ""b6ac9eef8c0f9508fc844fc55516dbdf105599fcbe3a51821c25c5f08774af9f"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11122 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11122""}]"	""
pathwaymech:GO_0042864_pch-edge-032_9f8eb7a0a58c	MetaCyc:RXN-11122	pathwaymech:produces	MetaCyc:Pyochelinyl-PchF	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:Pyochelinyl-PchF|MetaCyc:RXN-11122	Native PchF reactive-domain state; coefficient is not an enzyme assembly count.	"[{""reference_id"": ""MetaCyc:RXN-11122"", ""source_assertion"": ""The native right side explicitly contains Pyochelinyl-PchF with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11122\""]/right[*/@frameid=\""Pyochelinyl-PchF\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:Pyochelinyl-PchF"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""Pyochelinyl-PchF\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:Pyochelinyl-PchF"", ""source_sha256"": ""e3fab665611cb84736a4e891347f7e20288babb45ef8496cca4e9fcf05d264c5"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc Pyochelinyl-PchF original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Pyochelinyl-PchF""}, {""id"": ""MetaCyc:RXN-11122"", ""source_sha256"": ""b6ac9eef8c0f9508fc844fc55516dbdf105599fcbe3a51821c25c5f08774af9f"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11122 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11122""}]"	""
pathwaymech:GO_0042864_pch-edge-033_a6fb8135eb42	MetaCyc:RXN-11122	pathwaymech:produces	CHEBI:57856	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:57856|MetaCyc:ADENOSYL-HOMO-CYS|MetaCyc:RXN-11122		"[{""reference_id"": ""MetaCyc:RXN-11122"", ""source_assertion"": ""The native right side explicitly contains ADENOSYL-HOMO-CYS with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11122\""]/right[*/@frameid=\""ADENOSYL-HOMO-CYS\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:ADENOSYL-HOMO-CYS"", ""source_assertion"": ""The original ADENOSYL-HOMO-CYS structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:57856."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""ADENOSYL-HOMO-CYS\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:57856"", ""source_assertion"": ""CHEBI:57856 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:57856; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:57856"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:57856 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:ADENOSYL-HOMO-CYS"", ""source_sha256"": ""30ac63e3204f75a08ac4611e2fb2a3e06716641a9e7e767a0a3cb4c38e53867f"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc ADENOSYL-HOMO-CYS original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADENOSYL-HOMO-CYS""}, {""id"": ""MetaCyc:RXN-11122"", ""source_sha256"": ""b6ac9eef8c0f9508fc844fc55516dbdf105599fcbe3a51821c25c5f08774af9f"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11122 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11122""}]"	""
pathwaymech:GO_0042864_pch-edge-034_e71acaa495e9	MetaCyc:RXN-11122	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-11122		"[{""reference_id"": ""MetaCyc:RXN-11122"", ""source_assertion"": ""The native right side explicitly contains PROTON with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11122\""]/right[*/@frameid=\""PROTON\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The original PROTON structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:15378."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""PROTON\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""CHEBI:15378 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:15378; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:15378 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PROTON original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}, {""id"": ""MetaCyc:RXN-11122"", ""source_sha256"": ""b6ac9eef8c0f9508fc844fc55516dbdf105599fcbe3a51821c25c5f08774af9f"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11122 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11122""}]"	""
pathwaymech:GO_0042864_pch-edge-035_eb89f24b4e43	MetaCyc:Pyochelinyl-PchF	pathwaymech:consumes	MetaCyc:RXN-11123	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:Pyochelinyl-PchF|MetaCyc:RXN-11123	Native PchF reactive-domain state; coefficient is not an enzyme assembly count.	"[{""reference_id"": ""MetaCyc:RXN-11123"", ""source_assertion"": ""The native left side explicitly contains Pyochelinyl-PchF with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11123\""]/left[*/@frameid=\""Pyochelinyl-PchF\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:Pyochelinyl-PchF"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""Pyochelinyl-PchF\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:Pyochelinyl-PchF"", ""source_sha256"": ""e3fab665611cb84736a4e891347f7e20288babb45ef8496cca4e9fcf05d264c5"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc Pyochelinyl-PchF original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Pyochelinyl-PchF""}, {""id"": ""MetaCyc:RXN-11123"", ""source_sha256"": ""e3fbb29993d18b3d93a5ca0a4114e6c3fb3ad53d3d2244d7099023623000d0a7"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11123 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11123""}]"	""
pathwaymech:GO_0042864_pch-edge-036_39c1f1287e50	CHEBI:15377	pathwaymech:consumes	MetaCyc:RXN-11123	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15377|MetaCyc:RXN-11123|MetaCyc:WATER		"[{""reference_id"": ""MetaCyc:RXN-11123"", ""source_assertion"": ""The native left side explicitly contains WATER with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11123\""]/left[*/@frameid=\""WATER\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:WATER"", ""source_assertion"": ""The original WATER structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:15377."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""WATER\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:15377"", ""source_assertion"": ""CHEBI:15377 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:15377; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:15377"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:15377 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:RXN-11123"", ""source_sha256"": ""e3fbb29993d18b3d93a5ca0a4114e6c3fb3ad53d3d2244d7099023623000d0a7"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11123 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11123""}, {""id"": ""MetaCyc:WATER"", ""source_sha256"": ""47621552fb854daf04df0375c4540b0f42103652ec2d2a5f384ad06dead702e3"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc WATER original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:WATER""}]"	""
pathwaymech:GO_0042864_pch-edge-037_f8182d1350ea	MetaCyc:RXN-11123	pathwaymech:produces	MetaCyc:CPD-9992	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:67183|MetaCyc:CPD-9992|MetaCyc:RXN-11123|PMID:17938167	Formal native pyochelin I monoanion endpoint; no exclusive-I physiological product or I-selective release claim.	"[{""reference_id"": ""MetaCyc:RXN-11123"", ""source_assertion"": ""The native right side explicitly contains CPD-9992 with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11123\""]/right[*/@frameid=\""CPD-9992\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-9992"", ""source_assertion"": ""The issued CPD-9992 InChI has the monoanion layer /p-1 and the stereochemical layers /t9-,10+,13-/m1/s1. The structure alone does not establish physiological product ratios or enzyme release selectivity."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""CPD-9992\""]/inchi; /p-1 and /t9-,10+,13-/m1/s1""}, {""reference_id"": ""CHEBI:67183"", ""source_assertion"": ""ChEBI names this neutral structure pyochelin I. Its connectivity and stereochemical InChI layers match native CPD-9992 after removing /p-1; this independently derived I assignment is protonation-normalized, not exact charge equivalence."", ""source_locator"": ""/name; /chemical_data/charge; /default_structure/standard_inchi; explicit comparison with CPD-9992 /inchi after removal of /p-1""}, {""reference_id"": ""PMID:17938167"", ""source_assertion"": ""P. aeruginosa produces pyochelin I and II, differing at the interconverting thioaminal center; this does not establish I-selective release."", ""source_locator"": ""responseWrapper/resultList/result[id=\""17938167\""]/abstractText""}]"	"[{""id"": ""CHEBI:67183"", ""source_sha256"": ""fc153c75efbd093e81ba7f29dc5a770c7c91fd8632d6116890a3a53ae605d70a"", ""source_version"": ""Original ChEBI compound API response retrieved 2026-10-11; digest covers complete JSON response, neutral structure"", ""title"": ""ChEBI pyochelin I original compound JSON"", ""url"": ""https://www.ebi.ac.uk/chebi/backend/api/public/compound/67183/""}, {""id"": ""MetaCyc:CPD-9992"", ""source_sha256"": ""77704bfe876d0c42129d3f4cdb7ac3b4b6fae7621ccc7b56a901d8926a634339"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc CPD-9992 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-9992""}, {""id"": ""MetaCyc:RXN-11123"", ""source_sha256"": ""e3fbb29993d18b3d93a5ca0a4114e6c3fb3ad53d3d2244d7099023623000d0a7"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11123 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11123""}, {""id"": ""PMID:17938167"", ""source_sha256"": ""123a9717f1fd31430a6d384dad35a9ce02cd6cec3f9cd576690ee747539ec2b7"", ""source_version"": ""Original Europe PMC indexed primary metadata and abstract; full article not locally obtained; digest covers complete response"", ""title"": ""Pseudomonas fluorescens CHA0 produces enantio-pyochelin, the optical antipode of the Pseudomonas aeruginosa siderophore pyochelin."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:(10555976%20OR%2011467965%20OR%2015375116%20OR%2012696314%20OR%2012624097%20OR%2017938167)&format=xml&resultType=core""}]"	""
pathwaymech:GO_0042864_pch-edge-038_0b957c57a2f2	MetaCyc:RXN-11123	pathwaymech:produces	MetaCyc:PchF	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:PchF|MetaCyc:RXN-11123	Native PchF reactive-domain state; coefficient is not an enzyme assembly count.	"[{""reference_id"": ""MetaCyc:RXN-11123"", ""source_assertion"": ""The native right side explicitly contains PchF with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11123\""]/right[*/@frameid=\""PchF\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:PchF"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""PchF\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:PchF"", ""source_sha256"": ""e766f5cdf7c4e69939897db9b2eb30fbe335c8b1ca94933ac2598c5826a12180"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PchF original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PchF""}, {""id"": ""MetaCyc:RXN-11123"", ""source_sha256"": ""e3fbb29993d18b3d93a5ca0a4114e6c3fb3ad53d3d2244d7099023623000d0a7"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11123 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11123""}]"	""
pathwaymech:GO_0042864_pch-edge-039_9a6b3e8da83f	MetaCyc:RXN-11123	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-11123		"[{""reference_id"": ""MetaCyc:RXN-11123"", ""source_assertion"": ""The native right side explicitly contains PROTON with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11123\""]/right[*/@frameid=\""PROTON\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The original PROTON structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:15378."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""PROTON\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""CHEBI:15378 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:15378; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:15378 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PROTON original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}, {""id"": ""MetaCyc:RXN-11123"", ""source_sha256"": ""e3fbb29993d18b3d93a5ca0a4114e6c3fb3ad53d3d2244d7099023623000d0a7"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11123 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11123""}]"	""
pathwaymech:GO_0042864_pch-edge-040_d99b489ebeb8	CHEBI:144924	pathwaymech:consumes	MetaCyc:RXN-11125	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:144924|MetaCyc:CPD-12085|MetaCyc:RXN-11125		"[{""reference_id"": ""MetaCyc:RXN-11125"", ""source_assertion"": ""The native left side explicitly contains CPD-12085 with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11125\""]/left[*/@frameid=\""CPD-12085\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-12085"", ""source_assertion"": ""The original CPD-12085 structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:144924."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""CPD-12085\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:144924"", ""source_assertion"": ""CHEBI:144924 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:144924; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:144924"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:144924 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:CPD-12085"", ""source_sha256"": ""af840f13b48542de5820b3b3c8b9fc605b4ef1a7c94eab2fe4c868f8947637f2"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc CPD-12085 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-12085""}, {""id"": ""MetaCyc:RXN-11125"", ""source_sha256"": ""1bb527f849d8a433ac02a48213db1dbbf24dc92b2c3fc7e1f0dec4166590d09e"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11125 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11125""}]"	""
pathwaymech:GO_0042864_pch-edge-041_32fb9536dd6f	MetaCyc:PchE	pathwaymech:consumes	MetaCyc:RXN-11125	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:PchE|MetaCyc:RXN-11125	Native reactive-domain class; PchE aryl and peptidyl sites are separate reaction sites on the same polypeptide.	"[{""reference_id"": ""MetaCyc:RXN-11125"", ""source_assertion"": ""The native left side explicitly contains PchE with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11125\""]/left[*/@frameid=\""PchE\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:PchE"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""PchE\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:PchE"", ""source_sha256"": ""bfdebcfb211b197b193b45e0532c0e465d09398470ddf2085ccdfa6096926b48"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PchE original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PchE""}, {""id"": ""MetaCyc:RXN-11125"", ""source_sha256"": ""1bb527f849d8a433ac02a48213db1dbbf24dc92b2c3fc7e1f0dec4166590d09e"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11125 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11125""}]"	""
pathwaymech:GO_0042864_pch-edge-042_cd0e2cc322b8	MetaCyc:RXN-11125	pathwaymech:produces	MetaCyc:L-cysteinyl-PchE	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:L-cysteinyl-PchE|MetaCyc:RXN-11125	Native reactive-domain class; PchE aryl and peptidyl sites are separate reaction sites on the same polypeptide.	"[{""reference_id"": ""MetaCyc:RXN-11125"", ""source_assertion"": ""The native right side explicitly contains L-cysteinyl-PchE with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11125\""]/right[*/@frameid=\""L-cysteinyl-PchE\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:L-cysteinyl-PchE"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""L-cysteinyl-PchE\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:L-cysteinyl-PchE"", ""source_sha256"": ""43eb36b00819ba5bdac7cafe71b166029ce98b27b764d561fe09f270d065256c"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc L-cysteinyl-PchE original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:L-cysteinyl-PchE""}, {""id"": ""MetaCyc:RXN-11125"", ""source_sha256"": ""1bb527f849d8a433ac02a48213db1dbbf24dc92b2c3fc7e1f0dec4166590d09e"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11125 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11125""}]"	""
pathwaymech:GO_0042864_pch-edge-043_dbfb3e9e33cc	MetaCyc:RXN-11125	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:456215|MetaCyc:AMP|MetaCyc:RXN-11125		"[{""reference_id"": ""MetaCyc:RXN-11125"", ""source_assertion"": ""The native right side explicitly contains AMP with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11125\""]/right[*/@frameid=\""AMP\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:AMP"", ""source_assertion"": ""The original AMP structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:456215."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""AMP\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:456215"", ""source_assertion"": ""CHEBI:456215 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:456215; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:456215"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:456215 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:AMP"", ""source_sha256"": ""f4de874fe3fd147827332ac5f9544e83b533d99e1141ba599a73ac9853f65a62"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc AMP original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:AMP""}, {""id"": ""MetaCyc:RXN-11125"", ""source_sha256"": ""1bb527f849d8a433ac02a48213db1dbbf24dc92b2c3fc7e1f0dec4166590d09e"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11125 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11125""}]"	""
pathwaymech:GO_0042864_pch-edge-044_33c7cf58f292	MetaCyc:RXN-11125	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-11125		"[{""reference_id"": ""MetaCyc:RXN-11125"", ""source_assertion"": ""The native right side explicitly contains PROTON with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11125\""]/right[*/@frameid=\""PROTON\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The original PROTON structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:15378."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""PROTON\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""CHEBI:15378 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:15378; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:15378 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PROTON original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}, {""id"": ""MetaCyc:RXN-11125"", ""source_sha256"": ""1bb527f849d8a433ac02a48213db1dbbf24dc92b2c3fc7e1f0dec4166590d09e"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11125 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11125""}]"	""
pathwaymech:GO_0042864_pch-edge-045_b4870c3704bd	CHEBI:86458	pathwaymech:consumes	MetaCyc:RXN-19466	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:86458|MetaCyc:CPD-12084|MetaCyc:RXN-19466		"[{""reference_id"": ""MetaCyc:RXN-19466"", ""source_assertion"": ""The native left side explicitly contains CPD-12084 with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-19466\""]/left[*/@frameid=\""CPD-12084\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:CPD-12084"", ""source_assertion"": ""The original CPD-12084 structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:86458."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""CPD-12084\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:86458"", ""source_assertion"": ""CHEBI:86458 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:86458; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:86458"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:86458 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:CPD-12084"", ""source_sha256"": ""eab3b0c27eca19f6f4bceab5df5ebe1f6ff722dd2e783d0df396dd0c82fce946"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc CPD-12084 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPD-12084""}, {""id"": ""MetaCyc:RXN-19466"", ""source_sha256"": ""90b5b1326fbdd0bf342f808bf9107665ab0bd1afe37abf2329112023a479e9d0"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-19466 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19466""}]"	""
pathwaymech:GO_0042864_pch-edge-046_214764418e21	MetaCyc:PchE	pathwaymech:consumes	MetaCyc:RXN-19466	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:PchE|MetaCyc:RXN-19466	Native reactive-domain class; PchE aryl and peptidyl sites are separate reaction sites on the same polypeptide.	"[{""reference_id"": ""MetaCyc:RXN-19466"", ""source_assertion"": ""The native left side explicitly contains PchE with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-19466\""]/left[*/@frameid=\""PchE\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:PchE"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""PchE\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:PchE"", ""source_sha256"": ""bfdebcfb211b197b193b45e0532c0e465d09398470ddf2085ccdfa6096926b48"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PchE original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PchE""}, {""id"": ""MetaCyc:RXN-19466"", ""source_sha256"": ""90b5b1326fbdd0bf342f808bf9107665ab0bd1afe37abf2329112023a479e9d0"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-19466 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19466""}]"	""
pathwaymech:GO_0042864_pch-edge-047_148108133231	MetaCyc:RXN-19466	pathwaymech:produces	MetaCyc:Salicyl-PchE	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:RXN-19466|MetaCyc:Salicyl-PchE	Native reactive-domain class; PchE aryl and peptidyl sites are separate reaction sites on the same polypeptide.	"[{""reference_id"": ""MetaCyc:RXN-19466"", ""source_assertion"": ""The native right side explicitly contains Salicyl-PchE with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-19466\""]/right[*/@frameid=\""Salicyl-PchE\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:Salicyl-PchE"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""Salicyl-PchE\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:RXN-19466"", ""source_sha256"": ""90b5b1326fbdd0bf342f808bf9107665ab0bd1afe37abf2329112023a479e9d0"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-19466 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19466""}, {""id"": ""MetaCyc:Salicyl-PchE"", ""source_sha256"": ""01e47b7b1bb3239422dd2c11e85f8e8f660a6bd6c7ad6db21711bbffdca640db"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc Salicyl-PchE original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Salicyl-PchE""}]"	""
pathwaymech:GO_0042864_pch-edge-048_745724b930f3	MetaCyc:RXN-19466	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:456215|MetaCyc:AMP|MetaCyc:RXN-19466		"[{""reference_id"": ""MetaCyc:RXN-19466"", ""source_assertion"": ""The native right side explicitly contains AMP with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-19466\""]/right[*/@frameid=\""AMP\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:AMP"", ""source_assertion"": ""The original AMP structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:456215."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""AMP\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:456215"", ""source_assertion"": ""CHEBI:456215 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:456215; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:456215"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:456215 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:AMP"", ""source_sha256"": ""f4de874fe3fd147827332ac5f9544e83b533d99e1141ba599a73ac9853f65a62"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc AMP original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:AMP""}, {""id"": ""MetaCyc:RXN-19466"", ""source_sha256"": ""90b5b1326fbdd0bf342f808bf9107665ab0bd1afe37abf2329112023a479e9d0"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-19466 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19466""}]"	""
pathwaymech:GO_0042864_pch-edge-049_48e4f845891b	MetaCyc:RXN-19466	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-19466		"[{""reference_id"": ""MetaCyc:RXN-19466"", ""source_assertion"": ""The native right side explicitly contains PROTON with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-19466\""]/right[*/@frameid=\""PROTON\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The original PROTON structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:15378."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""PROTON\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""CHEBI:15378 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:15378; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:15378 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PROTON original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}, {""id"": ""MetaCyc:RXN-19466"", ""source_sha256"": ""90b5b1326fbdd0bf342f808bf9107665ab0bd1afe37abf2329112023a479e9d0"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-19466 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19466""}]"	""
pathwaymech:GO_0042864_pch-edge-050_80522dd08dc4	MetaCyc:Salicyl-PchE	pathwaymech:consumes	MetaCyc:RXN-19469	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:RXN-19469|MetaCyc:Salicyl-PchE	Native reactive-domain class; PchE aryl and peptidyl sites are separate reaction sites on the same polypeptide.	"[{""reference_id"": ""MetaCyc:RXN-19469"", ""source_assertion"": ""The native left side explicitly contains Salicyl-PchE with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-19469\""]/left[*/@frameid=\""Salicyl-PchE\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:Salicyl-PchE"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""Salicyl-PchE\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:RXN-19469"", ""source_sha256"": ""3dee7e8cac6b071cabc7022b8aecdab4418857a9af5fb2e79c258f31f262856e"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-19469 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19469""}, {""id"": ""MetaCyc:Salicyl-PchE"", ""source_sha256"": ""01e47b7b1bb3239422dd2c11e85f8e8f660a6bd6c7ad6db21711bbffdca640db"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc Salicyl-PchE original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Salicyl-PchE""}]"	""
pathwaymech:GO_0042864_pch-edge-051_7c33eabbfca6	MetaCyc:L-cysteinyl-PchE	pathwaymech:consumes	MetaCyc:RXN-19469	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:L-cysteinyl-PchE|MetaCyc:RXN-19469	Native reactive-domain class; PchE aryl and peptidyl sites are separate reaction sites on the same polypeptide.	"[{""reference_id"": ""MetaCyc:RXN-19469"", ""source_assertion"": ""The native left side explicitly contains L-cysteinyl-PchE with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-19469\""]/left[*/@frameid=\""L-cysteinyl-PchE\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:L-cysteinyl-PchE"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""L-cysteinyl-PchE\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:L-cysteinyl-PchE"", ""source_sha256"": ""43eb36b00819ba5bdac7cafe71b166029ce98b27b764d561fe09f270d065256c"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc L-cysteinyl-PchE original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:L-cysteinyl-PchE""}, {""id"": ""MetaCyc:RXN-19469"", ""source_sha256"": ""3dee7e8cac6b071cabc7022b8aecdab4418857a9af5fb2e79c258f31f262856e"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-19469 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19469""}]"	""
pathwaymech:GO_0042864_pch-edge-052_6d73ca62de7a	MetaCyc:RXN-19469	pathwaymech:produces	MetaCyc:Salicyl-L-cysteinyl-PchE	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:RXN-19469|MetaCyc:Salicyl-L-cysteinyl-PchE	Native reactive-domain class; PchE aryl and peptidyl sites are separate reaction sites on the same polypeptide.	"[{""reference_id"": ""MetaCyc:RXN-19469"", ""source_assertion"": ""The native right side explicitly contains Salicyl-L-cysteinyl-PchE with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-19469\""]/right[*/@frameid=\""Salicyl-L-cysteinyl-PchE\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:Salicyl-L-cysteinyl-PchE"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""Salicyl-L-cysteinyl-PchE\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:RXN-19469"", ""source_sha256"": ""3dee7e8cac6b071cabc7022b8aecdab4418857a9af5fb2e79c258f31f262856e"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-19469 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19469""}, {""id"": ""MetaCyc:Salicyl-L-cysteinyl-PchE"", ""source_sha256"": ""d6c791d2e6632f200e7d187c011f249ec216a446c3ceb3071e70aa37b0343f0e"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc Salicyl-L-cysteinyl-PchE original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Salicyl-L-cysteinyl-PchE""}]"	""
pathwaymech:GO_0042864_pch-edge-053_515969550145	MetaCyc:RXN-19469	pathwaymech:produces	MetaCyc:PchE	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1038/s41467-022-28284-x|MetaCyc:PchE|MetaCyc:RXN-19469	Native reactive-domain class; PchE aryl and peptidyl sites are separate reaction sites on the same polypeptide.	"[{""reference_id"": ""MetaCyc:RXN-19469"", ""source_assertion"": ""The native right side explicitly contains PchE with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-19469\""]/right[*/@frameid=\""PchE\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:PchE"", ""source_assertion"": ""The original frame explicitly declares a Protein class and names its carrier acyl state; it supplies no full protein sequence or atom-complete carrier structure."", ""source_locator"": ""ptools-xml/Protein[@frameid=\""PchE\""]/common-name; @class""}, {""reference_id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_assertion"": ""The original assembly diagram distinguishes the PchE ArCP and PCP sites and the PchF carrier site with covalent phosphopantetheine-tethered intermediates. Reactive-site accounting must not be read as whole-polypeptide coefficients."", ""source_locator"": ""Original supplement PDF page2, Supplementary Figure1c; page3, Supplementary Figure2""}]"	"[{""id"": ""DOI:10.1038/s41467-022-28284-x"", ""source_sha256"": ""0a3479387431da7fdb3143a34d4cf1c906c2ccf9b9563a9da57d8eb817811a1f"", ""source_version"": ""Original 27-page publisher supplement; Figure1c and Figure2 inspected; digest covers exact PDF bytes, not the main article"", ""title"": ""Supplementary Information for Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://api.repository.cam.ac.uk/server/api/core/bitstreams/d3ba54af-7039-4c69-b26c-36a18e1df919/content""}, {""id"": ""MetaCyc:PchE"", ""source_sha256"": ""bfdebcfb211b197b193b45e0532c0e465d09398470ddf2085ccdfa6096926b48"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PchE original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PchE""}, {""id"": ""MetaCyc:RXN-19469"", ""source_sha256"": ""3dee7e8cac6b071cabc7022b8aecdab4418857a9af5fb2e79c258f31f262856e"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-19469 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19469""}]"	""
pathwaymech:GO_0042864_pch-edge-054_7a658587f0ae	MetaCyc:RXN-19469	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:15378|MetaCyc:PROTON|MetaCyc:RXN-19469		"[{""reference_id"": ""MetaCyc:RXN-19469"", ""source_assertion"": ""The native right side explicitly contains PROTON with coefficient 1; direction is PHYSIOL-LEFT-TO-RIGHT."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-19469\""]/right[*/@frameid=\""PROTON\""]; reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The original PROTON structure defines the chemical form selected for this side; its InChI and charged atoms were compared with CHEBI:15378."", ""source_locator"": ""ptools-xml/Compound[@frameid=\""PROTON\""]/inchi; cml/molecule/atomArray/atom/@formalCharge""}, {""reference_id"": ""CHEBI:15378"", ""source_assertion"": ""CHEBI:15378 supplies the matching structure, formula and charge. Zwitterionic forms preserve the native amino/carboxyl charges where present."", ""source_locator"": ""Semantic SQL statements subject=CHEBI:15378; chemrof:inchi_string, chemrof:charge, chemrof:generalized_empirical_formula""}]"	"[{""id"": ""CHEBI:15378"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers the complete uncompressed original authority database"", ""title"": ""ChEBI 255 CHEBI:15378 original chemical structure and preferred name"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PROTON original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}, {""id"": ""MetaCyc:RXN-19469"", ""source_sha256"": ""3dee7e8cac6b071cabc7022b8aecdab4418857a9af5fb2e79c258f31f262856e"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-19469 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19469""}]"	""
pathwaymech:GO_0042864_pch-edge-055_08f3f534fb0e	UniProtKB:Q9HWG3	pathwaymech:enables	MetaCyc:RXN-11113	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:35105906|UniProtKB:Q9HWG3	PchD adenylates salicylate before transfer to the PchE aryl carrier site. Functional gene-product relation; no monomer sufficiency or stable PchDEFG assembly is asserted.	"[{""reference_id"": ""UniProtKB:Q9HWG3"", ""source_assertion"": ""Current PAO1 identity and functional annotation support this gene-product role. Detailed PchD and PchE/F steps include ECO:0000250 or ECO:0000305 inference; this is not a claim of purified monomer sufficiency."", ""source_locator"": ""/results/3/primaryAccession; /results/3/organism/taxonId; /results/3/comments/0; /results/3/sequence/value""}, {""reference_id"": ""PMID:35105906"", ""source_assertion"": ""PchD adenylates salicylate before transfer to the PchE aryl carrier site. The inspected work uses PAO1 genes and observes dimeric PchE; the functional relation does not assert a stable four-protein complex."", ""source_locator"": ""article/body//sec[@id=\""Sec1\""]; sec[@id=\""Sec4\""] and sec[@id=\""Sec5\""]; Methods article/body//sec[@id=\""Sec9\""]""}]"	"[{""id"": ""PMID:35105906"", ""source_sha256"": ""2ca176a96fc7b3b021c1d558d721e90289236528cf77f92ed1b94237ebc50153"", ""source_version"": ""Complete original Europe PMC JATS article XML retrieved 2026-10-11; digest covers whole response"", ""title"": ""Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8807600/fullTextXML""}, {""id"": ""UniProtKB:Q9HWG3"", ""source_sha256"": ""feb27451b2bc1ea3463bb31a50b6513870e495bcb6203fdde3a95f28b92daba3"", ""source_version"": ""UniProt 2026_03; complete original seven-entry response retrieved 2026-10-11; entry 3; digest covers whole batch"", ""title"": ""UniProtKB Q9HWG3 current complete PAO1 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A208964%29%20AND%20%28gene%3ApchD%20OR%20gene%3ApchE%20OR%20gene%3ApchF%20OR%20gene%3ApchG%20OR%20gene%3ApchC%20OR%20gene%3ApchA%20OR%20gene%3ApchB%20OR%20gene%3ApptA%29&format=json&size=100""}]"	""
pathwaymech:GO_0042864_pch-edge-056_b1f15cbc52ff	UniProtKB:G3XCV2	pathwaymech:enables	MetaCyc:RXN-11115	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:35105906|UniProtKB:G3XCV2	The PchE and PchF adenylation domains each activate a cysteine; one native reaction object is reused twice. Functional gene-product relation; no monomer sufficiency or stable PchDEFG assembly is asserted.	"[{""reference_id"": ""UniProtKB:G3XCV2"", ""source_assertion"": ""Current PAO1 identity and functional annotation support this gene-product role. Detailed PchD and PchE/F steps include ECO:0000250 or ECO:0000305 inference; this is not a claim of purified monomer sufficiency."", ""source_locator"": ""/results/1/primaryAccession; /results/1/organism/taxonId; /results/1/comments/0; /results/1/sequence/value""}, {""reference_id"": ""PMID:35105906"", ""source_assertion"": ""The PchE and PchF adenylation domains each activate a cysteine; one native reaction object is reused twice. The inspected work uses PAO1 genes and observes dimeric PchE; the functional relation does not assert a stable four-protein complex."", ""source_locator"": ""article/body//sec[@id=\""Sec1\""]; sec[@id=\""Sec4\""] and sec[@id=\""Sec5\""]; Methods article/body//sec[@id=\""Sec9\""]""}]"	"[{""id"": ""PMID:35105906"", ""source_sha256"": ""2ca176a96fc7b3b021c1d558d721e90289236528cf77f92ed1b94237ebc50153"", ""source_version"": ""Complete original Europe PMC JATS article XML retrieved 2026-10-11; digest covers whole response"", ""title"": ""Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8807600/fullTextXML""}, {""id"": ""UniProtKB:G3XCV2"", ""source_sha256"": ""feb27451b2bc1ea3463bb31a50b6513870e495bcb6203fdde3a95f28b92daba3"", ""source_version"": ""UniProt 2026_03; complete original seven-entry response retrieved 2026-10-11; entry 1; digest covers whole batch"", ""title"": ""UniProtKB G3XCV2 current complete PAO1 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A208964%29%20AND%20%28gene%3ApchD%20OR%20gene%3ApchE%20OR%20gene%3ApchF%20OR%20gene%3ApchG%20OR%20gene%3ApchC%20OR%20gene%3ApchA%20OR%20gene%3ApchB%20OR%20gene%3ApptA%29&format=json&size=100""}]"	""
pathwaymech:GO_0042864_pch-edge-057_14991b326ee8	UniProtKB:Q9HWG4	pathwaymech:enables	MetaCyc:RXN-11115	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11467965|PMID:30525512|UniProtKB:Q9HWG4	The PchE and PchF adenylation domains each activate a cysteine; one native reaction object is reused twice. Functional gene-product relation; no monomer sufficiency or stable PchDEFG assembly is asserted.	"[{""reference_id"": ""UniProtKB:Q9HWG4"", ""source_assertion"": ""Current PAO1 identity and functional annotation support this gene-product role. Detailed PchD and PchE/F steps include ECO:0000250 or ECO:0000305 inference; this is not a claim of purified monomer sufficiency."", ""source_locator"": ""/results/2/primaryAccession; /results/2/organism/taxonId; /results/2/comments/0; /results/2/sequence/value""}, {""reference_id"": ""PMID:30525512"", ""source_assertion"": ""The PchE and PchF adenylation domains each activate a cysteine; one native reaction object is reused twice. The study names O85740 and uses PAO1 constructs; detailed methylation tests use analogues, not complete thiotemplate steady-state turnover."", ""source_locator"": ""collection/document/passage[offset=\""9139\"" or offset=\""9446\"" or offset=\""41012\"" or offset=\""53276\"" or offset=\""65484\""]/text""}, {""reference_id"": ""PMID:11467965"", ""source_assertion"": ""Four-protein reconstitution assigns terminal reduction to PchG and methylation/release to PchF. Only the original indexed abstract was retained; no fixed DEFG heterotetramer follows."", ""source_locator"": ""responseWrapper/resultList/result[id=\""11467965\""]/abstractText""}]"	"[{""id"": ""PMID:11467965"", ""source_sha256"": ""123a9717f1fd31430a6d384dad35a9ce02cd6cec3f9cd576690ee747539ec2b7"", ""source_version"": ""Original Europe PMC indexed primary metadata and abstract; full article not locally obtained; digest covers complete response"", ""title"": ""In vitro reconstitution of the Pseudomonas aeruginosa nonribosomal peptide synthesis of pyochelin: characterization of backbone tailoring thiazoline reductase and N-methyltransferase activities."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:(10555976%20OR%2011467965%20OR%2015375116%20OR%2012696314%20OR%2012624097%20OR%2017938167)&format=xml&resultType=core""}, {""id"": ""PMID:30525512"", ""source_sha256"": ""44c81e2ba45ae788a520e9a0fdde1006980cb904222a3c3315079b3ead46d795"", ""source_version"": ""Complete original NCBI BioC author-manuscript XML export retrieved 2026-10-11; digest covers whole response"", ""title"": ""Stuffed Methyltransferase Catalyzes Penultimate Step of Pyochelin Biosynthesis"", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC6372355/unicode""}, {""id"": ""UniProtKB:Q9HWG4"", ""source_sha256"": ""feb27451b2bc1ea3463bb31a50b6513870e495bcb6203fdde3a95f28b92daba3"", ""source_version"": ""UniProt 2026_03; complete original seven-entry response retrieved 2026-10-11; entry 2; digest covers whole batch"", ""title"": ""UniProtKB Q9HWG4 current complete PAO1 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A208964%29%20AND%20%28gene%3ApchD%20OR%20gene%3ApchE%20OR%20gene%3ApchF%20OR%20gene%3ApchG%20OR%20gene%3ApchC%20OR%20gene%3ApchA%20OR%20gene%3ApchB%20OR%20gene%3ApptA%29&format=json&size=100""}]"	""
pathwaymech:GO_0042864_pch-edge-058_678b1e9b159d	UniProtKB:Q9HWG4	pathwaymech:enables	MetaCyc:RXN-11117	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11467965|PMID:30525512|UniProtKB:Q9HWG4	PchF loads its activated cysteine onto its carrier site. Functional gene-product relation; no monomer sufficiency or stable PchDEFG assembly is asserted.	"[{""reference_id"": ""UniProtKB:Q9HWG4"", ""source_assertion"": ""Current PAO1 identity and functional annotation support this gene-product role. Detailed PchD and PchE/F steps include ECO:0000250 or ECO:0000305 inference; this is not a claim of purified monomer sufficiency."", ""source_locator"": ""/results/2/primaryAccession; /results/2/organism/taxonId; /results/2/comments/0; /results/2/sequence/value""}, {""reference_id"": ""PMID:30525512"", ""source_assertion"": ""PchF loads its activated cysteine onto its carrier site. The study names O85740 and uses PAO1 constructs; detailed methylation tests use analogues, not complete thiotemplate steady-state turnover."", ""source_locator"": ""collection/document/passage[offset=\""9139\"" or offset=\""9446\"" or offset=\""41012\"" or offset=\""53276\"" or offset=\""65484\""]/text""}, {""reference_id"": ""PMID:11467965"", ""source_assertion"": ""Four-protein reconstitution assigns terminal reduction to PchG and methylation/release to PchF. Only the original indexed abstract was retained; no fixed DEFG heterotetramer follows."", ""source_locator"": ""responseWrapper/resultList/result[id=\""11467965\""]/abstractText""}]"	"[{""id"": ""PMID:11467965"", ""source_sha256"": ""123a9717f1fd31430a6d384dad35a9ce02cd6cec3f9cd576690ee747539ec2b7"", ""source_version"": ""Original Europe PMC indexed primary metadata and abstract; full article not locally obtained; digest covers complete response"", ""title"": ""In vitro reconstitution of the Pseudomonas aeruginosa nonribosomal peptide synthesis of pyochelin: characterization of backbone tailoring thiazoline reductase and N-methyltransferase activities."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:(10555976%20OR%2011467965%20OR%2015375116%20OR%2012696314%20OR%2012624097%20OR%2017938167)&format=xml&resultType=core""}, {""id"": ""PMID:30525512"", ""source_sha256"": ""44c81e2ba45ae788a520e9a0fdde1006980cb904222a3c3315079b3ead46d795"", ""source_version"": ""Complete original NCBI BioC author-manuscript XML export retrieved 2026-10-11; digest covers whole response"", ""title"": ""Stuffed Methyltransferase Catalyzes Penultimate Step of Pyochelin Biosynthesis"", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC6372355/unicode""}, {""id"": ""UniProtKB:Q9HWG4"", ""source_sha256"": ""feb27451b2bc1ea3463bb31a50b6513870e495bcb6203fdde3a95f28b92daba3"", ""source_version"": ""UniProt 2026_03; complete original seven-entry response retrieved 2026-10-11; entry 2; digest covers whole batch"", ""title"": ""UniProtKB Q9HWG4 current complete PAO1 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A208964%29%20AND%20%28gene%3ApchD%20OR%20gene%3ApchE%20OR%20gene%3ApchF%20OR%20gene%3ApchG%20OR%20gene%3ApchC%20OR%20gene%3ApchA%20OR%20gene%3ApchB%20OR%20gene%3ApptA%29&format=json&size=100""}]"	""
pathwaymech:GO_0042864_pch-edge-059_0ecb5a3d10ee	UniProtKB:G3XCV2	pathwaymech:enables	MetaCyc:RXN-11118	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:12950179|PMID:35105906|UniProtKB:G3XCV2	PchE performs first-ring cyclization with epimerization after amide formation. Functional gene-product relation; no monomer sufficiency or stable PchDEFG assembly is asserted.	"[{""reference_id"": ""UniProtKB:G3XCV2"", ""source_assertion"": ""Current PAO1 identity and functional annotation support this gene-product role. Detailed PchD and PchE/F steps include ECO:0000250 or ECO:0000305 inference; this is not a claim of purified monomer sufficiency."", ""source_locator"": ""/results/1/primaryAccession; /results/1/organism/taxonId; /results/1/comments/0; /results/1/sequence/value""}, {""reference_id"": ""PMID:35105906"", ""source_assertion"": ""PchE performs first-ring cyclization with epimerization after amide formation. The inspected work uses PAO1 genes and observes dimeric PchE; the functional relation does not assert a stable four-protein complex."", ""source_locator"": ""article/body//sec[@id=\""Sec1\""]; sec[@id=\""Sec4\""] and sec[@id=\""Sec5\""]; Methods article/body//sec[@id=\""Sec9\""]""}, {""reference_id"": ""PMID:12950179"", ""source_assertion"": ""Epimerization was detected after amide formation rather than on simple cysteinyl-S-PchE; the native ring-forming object compresses these coupled events."", ""source_locator"": ""responseWrapper/resultList/result[id=\""12950179\""]/abstractText""}]"	"[{""id"": ""PMID:12950179"", ""source_sha256"": ""822d7af37136a0104edf797fc36aee792b49d2e78274a4bf6d197599223598a5"", ""source_version"": ""Original Europe PMC indexed primary metadata and abstract; full article not locally obtained; digest covers complete response"", ""title"": ""Epimerization of an L-cysteinyl to a D-cysteinyl residue during thiazoline ring formation in siderophore chain elongation by pyochelin synthetase from Pseudomonas aeruginosa."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A11208777%20OR%20EXT_ID%3A9846750%20OR%20DOI%3A10.1021/bi034840c&resultType=core&format=xml""}, {""id"": ""PMID:35105906"", ""source_sha256"": ""2ca176a96fc7b3b021c1d558d721e90289236528cf77f92ed1b94237ebc50153"", ""source_version"": ""Complete original Europe PMC JATS article XML retrieved 2026-10-11; digest covers whole response"", ""title"": ""Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8807600/fullTextXML""}, {""id"": ""UniProtKB:G3XCV2"", ""source_sha256"": ""feb27451b2bc1ea3463bb31a50b6513870e495bcb6203fdde3a95f28b92daba3"", ""source_version"": ""UniProt 2026_03; complete original seven-entry response retrieved 2026-10-11; entry 1; digest covers whole batch"", ""title"": ""UniProtKB G3XCV2 current complete PAO1 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A208964%29%20AND%20%28gene%3ApchD%20OR%20gene%3ApchE%20OR%20gene%3ApchF%20OR%20gene%3ApchG%20OR%20gene%3ApchC%20OR%20gene%3ApchA%20OR%20gene%3ApchB%20OR%20gene%3ApptA%29&format=json&size=100""}]"	""
pathwaymech:GO_0042864_pch-edge-060_3abdd0b745d1	UniProtKB:Q9HWG4	pathwaymech:enables	MetaCyc:RXN-11120	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11467965|PMID:30525512|UniProtKB:Q9HWG4	PchF accepts the PchE-bound intermediate, condenses the second cysteine and forms the second thiazoline. Functional gene-product relation; no monomer sufficiency or stable PchDEFG assembly is asserted.	"[{""reference_id"": ""UniProtKB:Q9HWG4"", ""source_assertion"": ""Current PAO1 identity and functional annotation support this gene-product role. Detailed PchD and PchE/F steps include ECO:0000250 or ECO:0000305 inference; this is not a claim of purified monomer sufficiency."", ""source_locator"": ""/results/2/primaryAccession; /results/2/organism/taxonId; /results/2/comments/0; /results/2/sequence/value""}, {""reference_id"": ""PMID:30525512"", ""source_assertion"": ""PchF accepts the PchE-bound intermediate, condenses the second cysteine and forms the second thiazoline. The study names O85740 and uses PAO1 constructs; detailed methylation tests use analogues, not complete thiotemplate steady-state turnover."", ""source_locator"": ""collection/document/passage[offset=\""9139\"" or offset=\""9446\"" or offset=\""41012\"" or offset=\""53276\"" or offset=\""65484\""]/text""}, {""reference_id"": ""PMID:11467965"", ""source_assertion"": ""Four-protein reconstitution assigns terminal reduction to PchG and methylation/release to PchF. Only the original indexed abstract was retained; no fixed DEFG heterotetramer follows."", ""source_locator"": ""responseWrapper/resultList/result[id=\""11467965\""]/abstractText""}]"	"[{""id"": ""PMID:11467965"", ""source_sha256"": ""123a9717f1fd31430a6d384dad35a9ce02cd6cec3f9cd576690ee747539ec2b7"", ""source_version"": ""Original Europe PMC indexed primary metadata and abstract; full article not locally obtained; digest covers complete response"", ""title"": ""In vitro reconstitution of the Pseudomonas aeruginosa nonribosomal peptide synthesis of pyochelin: characterization of backbone tailoring thiazoline reductase and N-methyltransferase activities."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:(10555976%20OR%2011467965%20OR%2015375116%20OR%2012696314%20OR%2012624097%20OR%2017938167)&format=xml&resultType=core""}, {""id"": ""PMID:30525512"", ""source_sha256"": ""44c81e2ba45ae788a520e9a0fdde1006980cb904222a3c3315079b3ead46d795"", ""source_version"": ""Complete original NCBI BioC author-manuscript XML export retrieved 2026-10-11; digest covers whole response"", ""title"": ""Stuffed Methyltransferase Catalyzes Penultimate Step of Pyochelin Biosynthesis"", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC6372355/unicode""}, {""id"": ""UniProtKB:Q9HWG4"", ""source_sha256"": ""feb27451b2bc1ea3463bb31a50b6513870e495bcb6203fdde3a95f28b92daba3"", ""source_version"": ""UniProt 2026_03; complete original seven-entry response retrieved 2026-10-11; entry 2; digest covers whole batch"", ""title"": ""UniProtKB Q9HWG4 current complete PAO1 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A208964%29%20AND%20%28gene%3ApchD%20OR%20gene%3ApchE%20OR%20gene%3ApchF%20OR%20gene%3ApchG%20OR%20gene%3ApchC%20OR%20gene%3ApchA%20OR%20gene%3ApchB%20OR%20gene%3ApptA%29&format=json&size=100""}]"	""
pathwaymech:GO_0042864_pch-edge-061_c8160d0a2f38	UniProtKB:Q9HWG5	pathwaymech:enables	MetaCyc:RXN-11121	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11208777|PMID:11467965|PMID:27601130|UniProtKB:Q9HWG5	PchG reduces the PchF-tethered terminal thiazoline using NADPH. Functional gene-product relation; no monomer sufficiency or stable PchDEFG assembly is asserted.	"[{""reference_id"": ""UniProtKB:Q9HWG5"", ""source_assertion"": ""The current unreviewed PAO1 entry identifies PchG; the biochemical assignment is supported separately by original PAO1 evidence."", ""source_locator"": ""/results/5/primaryAccession; /results/5/organism/taxonId; /results/5/proteinDescription; /results/5/sequence/value""}, {""reference_id"": ""PMID:11467965"", ""source_assertion"": ""Purified PchG reduces the hydroxyphenylbisthiazoline-S-PchF acyl enzyme with NADPH during complete reconstitution. Only the original indexed abstract was retained; historical construct scope is distinct from exact current PAO1 sequence identity."", ""source_locator"": ""responseWrapper/resultList/result[id=\""11467965\""]/abstractText""}, {""reference_id"": ""PMID:11208777"", ""source_assertion"": ""P. aeruginosa genetics and biochemical reconstitution establish the PchG requirement for pyochelin synthesis, separately from the current unreviewed sequence annotation."", ""source_locator"": ""responseWrapper/resultList/result[id=\""11208777\""]/abstractText""}, {""reference_id"": ""PMID:27601130"", ""source_assertion"": ""PAO1-derived PchG reduces an oxidized free analogue with NADPH; the authors caution that this is a poor model for full physiological carrier-substrate kinetics and stereochemistry."", ""source_locator"": ""collection/document/passage[offset=\""4948\"" or offset=\""34049\""]/text; Results, Enzymatic Activity""}]"	"[{""id"": ""PMID:11208777"", ""source_sha256"": ""822d7af37136a0104edf797fc36aee792b49d2e78274a4bf6d197599223598a5"", ""source_version"": ""Original Europe PMC indexed primary metadata and abstract; full article not locally obtained; digest covers complete response"", ""title"": ""Essential PchG-dependent reduction in pyochelin biosynthesis of Pseudomonas aeruginosa."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A11208777%20OR%20EXT_ID%3A9846750%20OR%20DOI%3A10.1021/bi034840c&resultType=core&format=xml""}, {""id"": ""PMID:11467965"", ""source_sha256"": ""123a9717f1fd31430a6d384dad35a9ce02cd6cec3f9cd576690ee747539ec2b7"", ""source_version"": ""Original Europe PMC indexed primary metadata and abstract; full article not locally obtained; digest covers complete response"", ""title"": ""In vitro reconstitution of the Pseudomonas aeruginosa nonribosomal peptide synthesis of pyochelin: characterization of backbone tailoring thiazoline reductase and N-methyltransferase activities."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:(10555976%20OR%2011467965%20OR%2015375116%20OR%2012696314%20OR%2012624097%20OR%2017938167)&format=xml&resultType=core""}, {""id"": ""PMID:27601130"", ""source_sha256"": ""d1f5df4d7746c75b109f5e527da216271a3f782cbafd9ed33fc5efdcb3082e4b"", ""source_version"": ""Complete original NCBI BioC author-manuscript XML export retrieved 2026-10-11; digest covers whole response"", ""title"": ""Holo Structure and Steady State Kinetics of the Thiazolinyl Imine Reductases for Siderophore Biosynthesis"", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC5046821/unicode""}, {""id"": ""UniProtKB:Q9HWG5"", ""source_sha256"": ""feb27451b2bc1ea3463bb31a50b6513870e495bcb6203fdde3a95f28b92daba3"", ""source_version"": ""UniProt 2026_03; complete original seven-entry response retrieved 2026-10-11; entry 5; digest covers whole batch"", ""title"": ""UniProtKB Q9HWG5 current complete PAO1 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A208964%29%20AND%20%28gene%3ApchD%20OR%20gene%3ApchE%20OR%20gene%3ApchF%20OR%20gene%3ApchG%20OR%20gene%3ApchC%20OR%20gene%3ApchA%20OR%20gene%3ApchB%20OR%20gene%3ApptA%29&format=json&size=100""}]"	""
pathwaymech:GO_0042864_pch-edge-062_6cffaba083d1	UniProtKB:Q9HWG4	pathwaymech:enables	MetaCyc:RXN-11122	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11467965|PMID:30525512|UniProtKB:Q9HWG4	PchF methylates the reduced terminal nitrogen with SAM. Functional gene-product relation; no monomer sufficiency or stable PchDEFG assembly is asserted.	"[{""reference_id"": ""UniProtKB:Q9HWG4"", ""source_assertion"": ""The current entry identifies Q9HWG4 as PAO1 PchF and supplies its sequence. This identity evidence does not independently assign methylation or mature-product hydrolysis; those roles are supported by separate primary evidence."", ""source_locator"": ""/results/2/primaryAccession; /results/2/genes/0/geneName/value; /results/2/organism/taxonId; /results/2/sequence/value""}, {""reference_id"": ""PMID:30525512"", ""source_assertion"": ""PchF methylates the reduced terminal nitrogen with SAM. The study names O85740 and uses PAO1 constructs; detailed methylation tests use analogues, not complete thiotemplate steady-state turnover."", ""source_locator"": ""collection/document/passage[offset=\""9139\"" or offset=\""9446\"" or offset=\""41012\"" or offset=\""53276\"" or offset=\""65484\""]/text""}, {""reference_id"": ""PMID:11467965"", ""source_assertion"": ""Four-protein reconstitution assigns terminal reduction to PchG and methylation/release to PchF. Only the original indexed abstract was retained; no fixed DEFG heterotetramer follows."", ""source_locator"": ""responseWrapper/resultList/result[id=\""11467965\""]/abstractText""}]"	"[{""id"": ""PMID:11467965"", ""source_sha256"": ""123a9717f1fd31430a6d384dad35a9ce02cd6cec3f9cd576690ee747539ec2b7"", ""source_version"": ""Original Europe PMC indexed primary metadata and abstract; full article not locally obtained; digest covers complete response"", ""title"": ""In vitro reconstitution of the Pseudomonas aeruginosa nonribosomal peptide synthesis of pyochelin: characterization of backbone tailoring thiazoline reductase and N-methyltransferase activities."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:(10555976%20OR%2011467965%20OR%2015375116%20OR%2012696314%20OR%2012624097%20OR%2017938167)&format=xml&resultType=core""}, {""id"": ""PMID:30525512"", ""source_sha256"": ""44c81e2ba45ae788a520e9a0fdde1006980cb904222a3c3315079b3ead46d795"", ""source_version"": ""Complete original NCBI BioC author-manuscript XML export retrieved 2026-10-11; digest covers whole response"", ""title"": ""Stuffed Methyltransferase Catalyzes Penultimate Step of Pyochelin Biosynthesis"", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC6372355/unicode""}, {""id"": ""UniProtKB:Q9HWG4"", ""source_sha256"": ""feb27451b2bc1ea3463bb31a50b6513870e495bcb6203fdde3a95f28b92daba3"", ""source_version"": ""UniProt 2026_03; complete original seven-entry response retrieved 2026-10-11; entry 2; digest covers whole batch"", ""title"": ""UniProtKB Q9HWG4 current complete PAO1 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A208964%29%20AND%20%28gene%3ApchD%20OR%20gene%3ApchE%20OR%20gene%3ApchF%20OR%20gene%3ApchG%20OR%20gene%3ApchC%20OR%20gene%3ApchA%20OR%20gene%3ApchB%20OR%20gene%3ApptA%29&format=json&size=100""}]"	""
pathwaymech:GO_0042864_pch-edge-063_2c2e45bf7f7d	UniProtKB:Q9HWG4	pathwaymech:enables	MetaCyc:RXN-11123	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11467965|PMID:30525512|UniProtKB:Q9HWG4	PchF releases pyochelin by thioester hydrolysis; the native I structure is a formal projection of the observed I/II products. Functional gene-product relation; no monomer sufficiency or stable PchDEFG assembly is asserted.	"[{""reference_id"": ""UniProtKB:Q9HWG4"", ""source_assertion"": ""The current entry identifies Q9HWG4 as PAO1 PchF and supplies its sequence. This identity evidence does not independently assign methylation or mature-product hydrolysis; those roles are supported by separate primary evidence."", ""source_locator"": ""/results/2/primaryAccession; /results/2/genes/0/geneName/value; /results/2/organism/taxonId; /results/2/sequence/value""}, {""reference_id"": ""PMID:30525512"", ""source_assertion"": ""PchF releases pyochelin by thioester hydrolysis. The study names O85740 and uses PAO1 constructs; detailed methylation tests use analogues, not complete thiotemplate steady-state turnover."", ""source_locator"": ""collection/document/passage[offset=\""9139\"" or offset=\""9446\"" or offset=\""41012\"" or offset=\""53276\"" or offset=\""65484\""]/text""}, {""reference_id"": ""PMID:11467965"", ""source_assertion"": ""Four-protein reconstitution assigns terminal reduction to PchG and methylation/release to PchF. Only the original indexed abstract was retained; no fixed DEFG heterotetramer follows."", ""source_locator"": ""responseWrapper/resultList/result[id=\""11467965\""]/abstractText""}]"	"[{""id"": ""PMID:11467965"", ""source_sha256"": ""123a9717f1fd31430a6d384dad35a9ce02cd6cec3f9cd576690ee747539ec2b7"", ""source_version"": ""Original Europe PMC indexed primary metadata and abstract; full article not locally obtained; digest covers complete response"", ""title"": ""In vitro reconstitution of the Pseudomonas aeruginosa nonribosomal peptide synthesis of pyochelin: characterization of backbone tailoring thiazoline reductase and N-methyltransferase activities."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:(10555976%20OR%2011467965%20OR%2015375116%20OR%2012696314%20OR%2012624097%20OR%2017938167)&format=xml&resultType=core""}, {""id"": ""PMID:30525512"", ""source_sha256"": ""44c81e2ba45ae788a520e9a0fdde1006980cb904222a3c3315079b3ead46d795"", ""source_version"": ""Complete original NCBI BioC author-manuscript XML export retrieved 2026-10-11; digest covers whole response"", ""title"": ""Stuffed Methyltransferase Catalyzes Penultimate Step of Pyochelin Biosynthesis"", ""url"": ""https://www.ncbi.nlm.nih.gov/research/bionlp/RESTful/pmcoa.cgi/BioC_xml/PMC6372355/unicode""}, {""id"": ""UniProtKB:Q9HWG4"", ""source_sha256"": ""feb27451b2bc1ea3463bb31a50b6513870e495bcb6203fdde3a95f28b92daba3"", ""source_version"": ""UniProt 2026_03; complete original seven-entry response retrieved 2026-10-11; entry 2; digest covers whole batch"", ""title"": ""UniProtKB Q9HWG4 current complete PAO1 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A208964%29%20AND%20%28gene%3ApchD%20OR%20gene%3ApchE%20OR%20gene%3ApchF%20OR%20gene%3ApchG%20OR%20gene%3ApchC%20OR%20gene%3ApchA%20OR%20gene%3ApchB%20OR%20gene%3ApptA%29&format=json&size=100""}]"	""
pathwaymech:GO_0042864_pch-edge-064_f8428d2ddd27	UniProtKB:G3XCV2	pathwaymech:enables	MetaCyc:RXN-11125	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:35105906|UniProtKB:G3XCV2	PchE loads cysteine onto its peptidyl carrier site. Functional gene-product relation; no monomer sufficiency or stable PchDEFG assembly is asserted.	"[{""reference_id"": ""UniProtKB:G3XCV2"", ""source_assertion"": ""Current PAO1 identity and functional annotation support this gene-product role. Detailed PchD and PchE/F steps include ECO:0000250 or ECO:0000305 inference; this is not a claim of purified monomer sufficiency."", ""source_locator"": ""/results/1/primaryAccession; /results/1/organism/taxonId; /results/1/comments/0; /results/1/sequence/value""}, {""reference_id"": ""PMID:35105906"", ""source_assertion"": ""PchE loads cysteine onto its peptidyl carrier site. The inspected work uses PAO1 genes and observes dimeric PchE; the functional relation does not assert a stable four-protein complex."", ""source_locator"": ""article/body//sec[@id=\""Sec1\""]; sec[@id=\""Sec4\""] and sec[@id=\""Sec5\""]; Methods article/body//sec[@id=\""Sec9\""]""}]"	"[{""id"": ""PMID:35105906"", ""source_sha256"": ""2ca176a96fc7b3b021c1d558d721e90289236528cf77f92ed1b94237ebc50153"", ""source_version"": ""Complete original Europe PMC JATS article XML retrieved 2026-10-11; digest covers whole response"", ""title"": ""Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8807600/fullTextXML""}, {""id"": ""UniProtKB:G3XCV2"", ""source_sha256"": ""feb27451b2bc1ea3463bb31a50b6513870e495bcb6203fdde3a95f28b92daba3"", ""source_version"": ""UniProt 2026_03; complete original seven-entry response retrieved 2026-10-11; entry 1; digest covers whole batch"", ""title"": ""UniProtKB G3XCV2 current complete PAO1 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A208964%29%20AND%20%28gene%3ApchD%20OR%20gene%3ApchE%20OR%20gene%3ApchF%20OR%20gene%3ApchG%20OR%20gene%3ApchC%20OR%20gene%3ApchA%20OR%20gene%3ApchB%20OR%20gene%3ApptA%29&format=json&size=100""}]"	""
pathwaymech:GO_0042864_pch-edge-065_aa79564d9186	UniProtKB:Q9HWG3	pathwaymech:enables	MetaCyc:RXN-19466	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:35105906|UniProtKB:Q9HWG3	PchD transfers activated salicylate to the PchE aryl carrier site. Functional gene-product relation; no monomer sufficiency or stable PchDEFG assembly is asserted.	"[{""reference_id"": ""UniProtKB:Q9HWG3"", ""source_assertion"": ""Current PAO1 identity and functional annotation support this gene-product role. Detailed PchD and PchE/F steps include ECO:0000250 or ECO:0000305 inference; this is not a claim of purified monomer sufficiency."", ""source_locator"": ""/results/3/primaryAccession; /results/3/organism/taxonId; /results/3/comments/0; /results/3/sequence/value""}, {""reference_id"": ""PMID:35105906"", ""source_assertion"": ""PchD transfers activated salicylate to the PchE aryl carrier site. The inspected work uses PAO1 genes and observes dimeric PchE; the functional relation does not assert a stable four-protein complex."", ""source_locator"": ""article/body//sec[@id=\""Sec1\""]; sec[@id=\""Sec4\""] and sec[@id=\""Sec5\""]; Methods article/body//sec[@id=\""Sec9\""]""}]"	"[{""id"": ""PMID:35105906"", ""source_sha256"": ""2ca176a96fc7b3b021c1d558d721e90289236528cf77f92ed1b94237ebc50153"", ""source_version"": ""Complete original Europe PMC JATS article XML retrieved 2026-10-11; digest covers whole response"", ""title"": ""Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8807600/fullTextXML""}, {""id"": ""UniProtKB:Q9HWG3"", ""source_sha256"": ""feb27451b2bc1ea3463bb31a50b6513870e495bcb6203fdde3a95f28b92daba3"", ""source_version"": ""UniProt 2026_03; complete original seven-entry response retrieved 2026-10-11; entry 3; digest covers whole batch"", ""title"": ""UniProtKB Q9HWG3 current complete PAO1 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A208964%29%20AND%20%28gene%3ApchD%20OR%20gene%3ApchE%20OR%20gene%3ApchF%20OR%20gene%3ApchG%20OR%20gene%3ApchC%20OR%20gene%3ApchA%20OR%20gene%3ApchB%20OR%20gene%3ApptA%29&format=json&size=100""}]"	""
pathwaymech:GO_0042864_pch-edge-066_d2b5de3755bf	UniProtKB:G3XCV2	pathwaymech:enables	MetaCyc:RXN-19469	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:35105906|UniProtKB:G3XCV2	PchE condenses its aryl-site salicyl group with its peptidyl-site cysteinyl group. Functional gene-product relation; no monomer sufficiency or stable PchDEFG assembly is asserted.	"[{""reference_id"": ""UniProtKB:G3XCV2"", ""source_assertion"": ""Current PAO1 identity and functional annotation support this gene-product role. Detailed PchD and PchE/F steps include ECO:0000250 or ECO:0000305 inference; this is not a claim of purified monomer sufficiency."", ""source_locator"": ""/results/1/primaryAccession; /results/1/organism/taxonId; /results/1/comments/0; /results/1/sequence/value""}, {""reference_id"": ""PMID:35105906"", ""source_assertion"": ""PchE condenses its aryl-site salicyl group with its peptidyl-site cysteinyl group. The inspected work uses PAO1 genes and observes dimeric PchE; the functional relation does not assert a stable four-protein complex."", ""source_locator"": ""article/body//sec[@id=\""Sec1\""]; sec[@id=\""Sec4\""] and sec[@id=\""Sec5\""]; Methods article/body//sec[@id=\""Sec9\""]""}]"	"[{""id"": ""PMID:35105906"", ""source_sha256"": ""2ca176a96fc7b3b021c1d558d721e90289236528cf77f92ed1b94237ebc50153"", ""source_version"": ""Complete original Europe PMC JATS article XML retrieved 2026-10-11; digest covers whole response"", ""title"": ""Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8807600/fullTextXML""}, {""id"": ""UniProtKB:G3XCV2"", ""source_sha256"": ""feb27451b2bc1ea3463bb31a50b6513870e495bcb6203fdde3a95f28b92daba3"", ""source_version"": ""UniProt 2026_03; complete original seven-entry response retrieved 2026-10-11; entry 1; digest covers whole batch"", ""title"": ""UniProtKB G3XCV2 current complete PAO1 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A208964%29%20AND%20%28gene%3ApchD%20OR%20gene%3ApchE%20OR%20gene%3ApchF%20OR%20gene%3ApchG%20OR%20gene%3ApchC%20OR%20gene%3ApchA%20OR%20gene%3ApchB%20OR%20gene%3ApptA%29&format=json&size=100""}]"	""
pathwaymech:GO_0042864_pch-edge-067_dd86a9de199e	UniProtKB:G3XCV2	pathwaymech:has_cofactor	CHEBI:47942	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:G3XCV2	Covalently attached carrier-arm moiety; no free-cofactor consumption or inferred whole-protein count.	"[{""reference_id"": ""UniProtKB:G3XCV2"", ""source_assertion"": ""The entry assigns pantetheine 4'-phosphate as a cofactor with ECO:0000305. In this pathway its covalently attached arm carries intermediates; it is not a free stoichiometric substrate."", ""source_locator"": ""/results/1/comments/2/cofactors/0; cofactorCrossReference/id=CHEBI:47942""}]"	"[{""id"": ""UniProtKB:G3XCV2"", ""source_sha256"": ""feb27451b2bc1ea3463bb31a50b6513870e495bcb6203fdde3a95f28b92daba3"", ""source_version"": ""UniProt 2026_03; complete original seven-entry response retrieved 2026-10-11; entry 1; digest covers whole batch"", ""title"": ""UniProtKB G3XCV2 current complete PAO1 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A208964%29%20AND%20%28gene%3ApchD%20OR%20gene%3ApchE%20OR%20gene%3ApchF%20OR%20gene%3ApchG%20OR%20gene%3ApchC%20OR%20gene%3ApchA%20OR%20gene%3ApchB%20OR%20gene%3ApptA%29&format=json&size=100""}]"	""
pathwaymech:GO_0042864_pch-edge-068_cede0ce51056	UniProtKB:Q9HWG4	pathwaymech:has_cofactor	CHEBI:47942	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q9HWG4	Covalently attached carrier-arm moiety; no free-cofactor consumption or inferred whole-protein count.	"[{""reference_id"": ""UniProtKB:Q9HWG4"", ""source_assertion"": ""The entry assigns pantetheine 4'-phosphate as a cofactor with ECO:0000305. In this pathway its covalently attached arm carries intermediates; it is not a free stoichiometric substrate."", ""source_locator"": ""/results/2/comments/2/cofactors/0; cofactorCrossReference/id=CHEBI:47942""}]"	"[{""id"": ""UniProtKB:Q9HWG4"", ""source_sha256"": ""feb27451b2bc1ea3463bb31a50b6513870e495bcb6203fdde3a95f28b92daba3"", ""source_version"": ""UniProt 2026_03; complete original seven-entry response retrieved 2026-10-11; entry 2; digest covers whole batch"", ""title"": ""UniProtKB Q9HWG4 current complete PAO1 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28organism_id%3A208964%29%20AND%20%28gene%3ApchD%20OR%20gene%3ApchE%20OR%20gene%3ApchF%20OR%20gene%3ApchG%20OR%20gene%3ApchC%20OR%20gene%3ApchA%20OR%20gene%3ApchB%20OR%20gene%3ApptA%29&format=json&size=100""}]"	""
pathwaymech:GO_0042864_pch-edge-069_2e70c41edaab	UniProtKB:G3XCV2	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:35105906	Direct bound-metal observation in the PAO1 PchE construct; no transfer of an MgATP assay condition to other proteins.	"[{""reference_id"": ""PMID:35105906"", ""source_assertion"": ""Cryo-EM structures directly place Mg2+ with cysteinyl-AMP in the PchE A-domain pocket. This supports bound magnesium in the inspected PAO1 construct, without a universal metal-dependence or stoichiometric claim."", ""source_locator"": ""article/body//sec[@id=\""Sec5\""]/p describing cysteinyl-AMP and Mg2+; Figure 3b""}]"	"[{""id"": ""PMID:35105906"", ""source_sha256"": ""2ca176a96fc7b3b021c1d558d721e90289236528cf77f92ed1b94237ebc50153"", ""source_version"": ""Complete original Europe PMC JATS article XML retrieved 2026-10-11; digest covers whole response"", ""title"": ""Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8807600/fullTextXML""}]"	""
pathwaymech:GO_0042864_pch-edge-070_3db0c44cbe74	MetaCyc:RXN-11113	BFO:0000050	GO:0042864	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0042864|MetaCyc:PWY-6408		"[{""reference_id"": ""MetaCyc:PWY-6408"", ""source_assertion"": ""The complete native reaction-list contains RXN-11113; the selected scope begins at salicylate and retains all eleven listed reaction objects."", ""source_locator"": ""ptools-xml/Pathway[@frameid=\""PWY-6408\""]/reaction-list/Reaction[@frameid=\""RXN-11113\""]""}, {""reference_id"": ""GO:0042864"", ""source_assertion"": ""The active GO process denotes chemical reactions and pathways forming pyochelin; this record describes the complete native salicylate-dependent implementation."", ""source_locator"": ""/results/0/id; /results/0/isObsolete; /results/0/definition/text""}]"	"[{""id"": ""GO:0042864"", ""source_sha256"": ""9c373a2b9612d1102990c580772c333c21340892b8f5a69d4b5e5d6c3d811acd"", ""source_version"": ""Original QuickGO term response retrieved 2026-10-11; active exact process identity"", ""title"": ""Gene Ontology GO:0042864 pyochelin biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0042864""}, {""id"": ""MetaCyc:PWY-6408"", ""source_sha256"": ""5c827d5f1d58d0fadf8c90b1c3be5d0b82ad857fa891fe9599e4863b783fee94"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PWY-6408 pyochelin biosynthesis original pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6408""}]"	""
pathwaymech:GO_0042864_pch-edge-071_75a3b0377eb8	MetaCyc:RXN-11115	BFO:0000050	GO:0042864	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0042864|MetaCyc:PWY-6408		"[{""reference_id"": ""MetaCyc:PWY-6408"", ""source_assertion"": ""The complete native reaction-list contains RXN-11115; the selected scope begins at salicylate and retains all eleven listed reaction objects."", ""source_locator"": ""ptools-xml/Pathway[@frameid=\""PWY-6408\""]/reaction-list/Reaction[@frameid=\""RXN-11115\""]""}, {""reference_id"": ""GO:0042864"", ""source_assertion"": ""The active GO process denotes chemical reactions and pathways forming pyochelin; this record describes the complete native salicylate-dependent implementation."", ""source_locator"": ""/results/0/id; /results/0/isObsolete; /results/0/definition/text""}]"	"[{""id"": ""GO:0042864"", ""source_sha256"": ""9c373a2b9612d1102990c580772c333c21340892b8f5a69d4b5e5d6c3d811acd"", ""source_version"": ""Original QuickGO term response retrieved 2026-10-11; active exact process identity"", ""title"": ""Gene Ontology GO:0042864 pyochelin biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0042864""}, {""id"": ""MetaCyc:PWY-6408"", ""source_sha256"": ""5c827d5f1d58d0fadf8c90b1c3be5d0b82ad857fa891fe9599e4863b783fee94"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PWY-6408 pyochelin biosynthesis original pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6408""}]"	""
pathwaymech:GO_0042864_pch-edge-072_7dc7ff8984a1	MetaCyc:RXN-11117	BFO:0000050	GO:0042864	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0042864|MetaCyc:PWY-6408		"[{""reference_id"": ""MetaCyc:PWY-6408"", ""source_assertion"": ""The complete native reaction-list contains RXN-11117; the selected scope begins at salicylate and retains all eleven listed reaction objects."", ""source_locator"": ""ptools-xml/Pathway[@frameid=\""PWY-6408\""]/reaction-list/Reaction[@frameid=\""RXN-11117\""]""}, {""reference_id"": ""GO:0042864"", ""source_assertion"": ""The active GO process denotes chemical reactions and pathways forming pyochelin; this record describes the complete native salicylate-dependent implementation."", ""source_locator"": ""/results/0/id; /results/0/isObsolete; /results/0/definition/text""}]"	"[{""id"": ""GO:0042864"", ""source_sha256"": ""9c373a2b9612d1102990c580772c333c21340892b8f5a69d4b5e5d6c3d811acd"", ""source_version"": ""Original QuickGO term response retrieved 2026-10-11; active exact process identity"", ""title"": ""Gene Ontology GO:0042864 pyochelin biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0042864""}, {""id"": ""MetaCyc:PWY-6408"", ""source_sha256"": ""5c827d5f1d58d0fadf8c90b1c3be5d0b82ad857fa891fe9599e4863b783fee94"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PWY-6408 pyochelin biosynthesis original pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6408""}]"	""
pathwaymech:GO_0042864_pch-edge-073_ce010de6135b	MetaCyc:RXN-11118	BFO:0000050	GO:0042864	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0042864|MetaCyc:PWY-6408		"[{""reference_id"": ""MetaCyc:PWY-6408"", ""source_assertion"": ""The complete native reaction-list contains RXN-11118; the selected scope begins at salicylate and retains all eleven listed reaction objects."", ""source_locator"": ""ptools-xml/Pathway[@frameid=\""PWY-6408\""]/reaction-list/Reaction[@frameid=\""RXN-11118\""]""}, {""reference_id"": ""GO:0042864"", ""source_assertion"": ""The active GO process denotes chemical reactions and pathways forming pyochelin; this record describes the complete native salicylate-dependent implementation."", ""source_locator"": ""/results/0/id; /results/0/isObsolete; /results/0/definition/text""}]"	"[{""id"": ""GO:0042864"", ""source_sha256"": ""9c373a2b9612d1102990c580772c333c21340892b8f5a69d4b5e5d6c3d811acd"", ""source_version"": ""Original QuickGO term response retrieved 2026-10-11; active exact process identity"", ""title"": ""Gene Ontology GO:0042864 pyochelin biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0042864""}, {""id"": ""MetaCyc:PWY-6408"", ""source_sha256"": ""5c827d5f1d58d0fadf8c90b1c3be5d0b82ad857fa891fe9599e4863b783fee94"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PWY-6408 pyochelin biosynthesis original pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6408""}]"	""
pathwaymech:GO_0042864_pch-edge-074_4c5bfc594ee3	MetaCyc:RXN-11120	BFO:0000050	GO:0042864	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0042864|MetaCyc:PWY-6408		"[{""reference_id"": ""MetaCyc:PWY-6408"", ""source_assertion"": ""The complete native reaction-list contains RXN-11120; the selected scope begins at salicylate and retains all eleven listed reaction objects."", ""source_locator"": ""ptools-xml/Pathway[@frameid=\""PWY-6408\""]/reaction-list/Reaction[@frameid=\""RXN-11120\""]""}, {""reference_id"": ""GO:0042864"", ""source_assertion"": ""The active GO process denotes chemical reactions and pathways forming pyochelin; this record describes the complete native salicylate-dependent implementation."", ""source_locator"": ""/results/0/id; /results/0/isObsolete; /results/0/definition/text""}]"	"[{""id"": ""GO:0042864"", ""source_sha256"": ""9c373a2b9612d1102990c580772c333c21340892b8f5a69d4b5e5d6c3d811acd"", ""source_version"": ""Original QuickGO term response retrieved 2026-10-11; active exact process identity"", ""title"": ""Gene Ontology GO:0042864 pyochelin biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0042864""}, {""id"": ""MetaCyc:PWY-6408"", ""source_sha256"": ""5c827d5f1d58d0fadf8c90b1c3be5d0b82ad857fa891fe9599e4863b783fee94"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PWY-6408 pyochelin biosynthesis original pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6408""}]"	""
pathwaymech:GO_0042864_pch-edge-075_f89e29ce05d0	MetaCyc:RXN-11121	BFO:0000050	GO:0042864	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0042864|MetaCyc:PWY-6408		"[{""reference_id"": ""MetaCyc:PWY-6408"", ""source_assertion"": ""The complete native reaction-list contains RXN-11121; the selected scope begins at salicylate and retains all eleven listed reaction objects."", ""source_locator"": ""ptools-xml/Pathway[@frameid=\""PWY-6408\""]/reaction-list/Reaction[@frameid=\""RXN-11121\""]""}, {""reference_id"": ""GO:0042864"", ""source_assertion"": ""The active GO process denotes chemical reactions and pathways forming pyochelin; this record describes the complete native salicylate-dependent implementation."", ""source_locator"": ""/results/0/id; /results/0/isObsolete; /results/0/definition/text""}]"	"[{""id"": ""GO:0042864"", ""source_sha256"": ""9c373a2b9612d1102990c580772c333c21340892b8f5a69d4b5e5d6c3d811acd"", ""source_version"": ""Original QuickGO term response retrieved 2026-10-11; active exact process identity"", ""title"": ""Gene Ontology GO:0042864 pyochelin biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0042864""}, {""id"": ""MetaCyc:PWY-6408"", ""source_sha256"": ""5c827d5f1d58d0fadf8c90b1c3be5d0b82ad857fa891fe9599e4863b783fee94"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PWY-6408 pyochelin biosynthesis original pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6408""}]"	""
pathwaymech:GO_0042864_pch-edge-076_9545ab27fd2d	MetaCyc:RXN-11122	BFO:0000050	GO:0042864	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0042864|MetaCyc:PWY-6408		"[{""reference_id"": ""MetaCyc:PWY-6408"", ""source_assertion"": ""The complete native reaction-list contains RXN-11122; the selected scope begins at salicylate and retains all eleven listed reaction objects."", ""source_locator"": ""ptools-xml/Pathway[@frameid=\""PWY-6408\""]/reaction-list/Reaction[@frameid=\""RXN-11122\""]""}, {""reference_id"": ""GO:0042864"", ""source_assertion"": ""The active GO process denotes chemical reactions and pathways forming pyochelin; this record describes the complete native salicylate-dependent implementation."", ""source_locator"": ""/results/0/id; /results/0/isObsolete; /results/0/definition/text""}]"	"[{""id"": ""GO:0042864"", ""source_sha256"": ""9c373a2b9612d1102990c580772c333c21340892b8f5a69d4b5e5d6c3d811acd"", ""source_version"": ""Original QuickGO term response retrieved 2026-10-11; active exact process identity"", ""title"": ""Gene Ontology GO:0042864 pyochelin biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0042864""}, {""id"": ""MetaCyc:PWY-6408"", ""source_sha256"": ""5c827d5f1d58d0fadf8c90b1c3be5d0b82ad857fa891fe9599e4863b783fee94"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PWY-6408 pyochelin biosynthesis original pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6408""}]"	""
pathwaymech:GO_0042864_pch-edge-077_8454b64f1fec	MetaCyc:RXN-11123	BFO:0000050	GO:0042864	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0042864|MetaCyc:PWY-6408		"[{""reference_id"": ""MetaCyc:PWY-6408"", ""source_assertion"": ""The complete native reaction-list contains RXN-11123; the selected scope begins at salicylate and retains all eleven listed reaction objects."", ""source_locator"": ""ptools-xml/Pathway[@frameid=\""PWY-6408\""]/reaction-list/Reaction[@frameid=\""RXN-11123\""]""}, {""reference_id"": ""GO:0042864"", ""source_assertion"": ""The active GO process denotes chemical reactions and pathways forming pyochelin; this record describes the complete native salicylate-dependent implementation."", ""source_locator"": ""/results/0/id; /results/0/isObsolete; /results/0/definition/text""}]"	"[{""id"": ""GO:0042864"", ""source_sha256"": ""9c373a2b9612d1102990c580772c333c21340892b8f5a69d4b5e5d6c3d811acd"", ""source_version"": ""Original QuickGO term response retrieved 2026-10-11; active exact process identity"", ""title"": ""Gene Ontology GO:0042864 pyochelin biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0042864""}, {""id"": ""MetaCyc:PWY-6408"", ""source_sha256"": ""5c827d5f1d58d0fadf8c90b1c3be5d0b82ad857fa891fe9599e4863b783fee94"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PWY-6408 pyochelin biosynthesis original pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6408""}]"	""
pathwaymech:GO_0042864_pch-edge-078_24e423db6b48	MetaCyc:RXN-11125	BFO:0000050	GO:0042864	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0042864|MetaCyc:PWY-6408		"[{""reference_id"": ""MetaCyc:PWY-6408"", ""source_assertion"": ""The complete native reaction-list contains RXN-11125; the selected scope begins at salicylate and retains all eleven listed reaction objects."", ""source_locator"": ""ptools-xml/Pathway[@frameid=\""PWY-6408\""]/reaction-list/Reaction[@frameid=\""RXN-11125\""]""}, {""reference_id"": ""GO:0042864"", ""source_assertion"": ""The active GO process denotes chemical reactions and pathways forming pyochelin; this record describes the complete native salicylate-dependent implementation."", ""source_locator"": ""/results/0/id; /results/0/isObsolete; /results/0/definition/text""}]"	"[{""id"": ""GO:0042864"", ""source_sha256"": ""9c373a2b9612d1102990c580772c333c21340892b8f5a69d4b5e5d6c3d811acd"", ""source_version"": ""Original QuickGO term response retrieved 2026-10-11; active exact process identity"", ""title"": ""Gene Ontology GO:0042864 pyochelin biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0042864""}, {""id"": ""MetaCyc:PWY-6408"", ""source_sha256"": ""5c827d5f1d58d0fadf8c90b1c3be5d0b82ad857fa891fe9599e4863b783fee94"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PWY-6408 pyochelin biosynthesis original pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6408""}]"	""
pathwaymech:GO_0042864_pch-edge-079_4d886263b9f0	MetaCyc:RXN-19466	BFO:0000050	GO:0042864	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0042864|MetaCyc:PWY-6408		"[{""reference_id"": ""MetaCyc:PWY-6408"", ""source_assertion"": ""The complete native reaction-list contains RXN-19466; the selected scope begins at salicylate and retains all eleven listed reaction objects."", ""source_locator"": ""ptools-xml/Pathway[@frameid=\""PWY-6408\""]/reaction-list/Reaction[@frameid=\""RXN-19466\""]""}, {""reference_id"": ""GO:0042864"", ""source_assertion"": ""The active GO process denotes chemical reactions and pathways forming pyochelin; this record describes the complete native salicylate-dependent implementation."", ""source_locator"": ""/results/0/id; /results/0/isObsolete; /results/0/definition/text""}]"	"[{""id"": ""GO:0042864"", ""source_sha256"": ""9c373a2b9612d1102990c580772c333c21340892b8f5a69d4b5e5d6c3d811acd"", ""source_version"": ""Original QuickGO term response retrieved 2026-10-11; active exact process identity"", ""title"": ""Gene Ontology GO:0042864 pyochelin biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0042864""}, {""id"": ""MetaCyc:PWY-6408"", ""source_sha256"": ""5c827d5f1d58d0fadf8c90b1c3be5d0b82ad857fa891fe9599e4863b783fee94"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PWY-6408 pyochelin biosynthesis original pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6408""}]"	""
pathwaymech:GO_0042864_pch-edge-080_83b43c17b78a	MetaCyc:RXN-19469	BFO:0000050	GO:0042864	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0042864|MetaCyc:PWY-6408		"[{""reference_id"": ""MetaCyc:PWY-6408"", ""source_assertion"": ""The complete native reaction-list contains RXN-19469; the selected scope begins at salicylate and retains all eleven listed reaction objects."", ""source_locator"": ""ptools-xml/Pathway[@frameid=\""PWY-6408\""]/reaction-list/Reaction[@frameid=\""RXN-19469\""]""}, {""reference_id"": ""GO:0042864"", ""source_assertion"": ""The active GO process denotes chemical reactions and pathways forming pyochelin; this record describes the complete native salicylate-dependent implementation."", ""source_locator"": ""/results/0/id; /results/0/isObsolete; /results/0/definition/text""}]"	"[{""id"": ""GO:0042864"", ""source_sha256"": ""9c373a2b9612d1102990c580772c333c21340892b8f5a69d4b5e5d6c3d811acd"", ""source_version"": ""Original QuickGO term response retrieved 2026-10-11; active exact process identity"", ""title"": ""Gene Ontology GO:0042864 pyochelin biosynthetic process"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0042864""}, {""id"": ""MetaCyc:PWY-6408"", ""source_sha256"": ""5c827d5f1d58d0fadf8c90b1c3be5d0b82ad857fa891fe9599e4863b783fee94"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc PWY-6408 pyochelin biosynthesis original pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6408""}]"	""
pathwaymech:GO_0042864_pch-edge-081_4e80ecefa940	MetaCyc:RXN-11113	RO:0002413	MetaCyc:RXN-19466	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11113|MetaCyc:RXN-19466		"[{""reference_id"": ""MetaCyc:RXN-11113"", ""source_assertion"": ""The original product side contains CPD-12084; the subsequent reaction consumes that same source-native intermediate."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11113\""]/right[*/@frameid=\""CPD-12084\""]""}, {""reference_id"": ""MetaCyc:RXN-19466"", ""source_assertion"": ""The original substrate side contains CPD-12084; this supplies the second half of the intermediate bridge."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-19466\""]/left[*/@frameid=\""CPD-12084\""]""}]"	"[{""id"": ""MetaCyc:RXN-11113"", ""source_sha256"": ""71773aac1fddaeb718877d7fa918971ef6933a19317443f1759c2b70e54fc087"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11113 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11113""}, {""id"": ""MetaCyc:RXN-19466"", ""source_sha256"": ""90b5b1326fbdd0bf342f808bf9107665ab0bd1afe37abf2329112023a479e9d0"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-19466 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19466""}]"	""
pathwaymech:GO_0042864_pch-edge-082_571294a45c78	MetaCyc:RXN-11115	RO:0002413	MetaCyc:RXN-11125	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11115|MetaCyc:RXN-11125		"[{""reference_id"": ""MetaCyc:RXN-11115"", ""source_assertion"": ""The original product side contains CPD-12085; the subsequent reaction consumes that same source-native intermediate."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11115\""]/right[*/@frameid=\""CPD-12085\""]""}, {""reference_id"": ""MetaCyc:RXN-11125"", ""source_assertion"": ""The original substrate side contains CPD-12085; this supplies the second half of the intermediate bridge."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11125\""]/left[*/@frameid=\""CPD-12085\""]""}]"	"[{""id"": ""MetaCyc:RXN-11115"", ""source_sha256"": ""0c41201a721f9458ccb3108759e8756b0584a62b1f7ccea6799e2e3c24105164"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11115 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11115""}, {""id"": ""MetaCyc:RXN-11125"", ""source_sha256"": ""1bb527f849d8a433ac02a48213db1dbbf24dc92b2c3fc7e1f0dec4166590d09e"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11125 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11125""}]"	""
pathwaymech:GO_0042864_pch-edge-083_9b899614ccd4	MetaCyc:RXN-11115	RO:0002413	MetaCyc:RXN-11117	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11115|MetaCyc:RXN-11117		"[{""reference_id"": ""MetaCyc:RXN-11115"", ""source_assertion"": ""The original product side contains CPD-12085; the subsequent reaction consumes that same source-native intermediate."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11115\""]/right[*/@frameid=\""CPD-12085\""]""}, {""reference_id"": ""MetaCyc:RXN-11117"", ""source_assertion"": ""The original substrate side contains CPD-12085; this supplies the second half of the intermediate bridge."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11117\""]/left[*/@frameid=\""CPD-12085\""]""}]"	"[{""id"": ""MetaCyc:RXN-11115"", ""source_sha256"": ""0c41201a721f9458ccb3108759e8756b0584a62b1f7ccea6799e2e3c24105164"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11115 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11115""}, {""id"": ""MetaCyc:RXN-11117"", ""source_sha256"": ""397e1a01575feef9f7d0e3743d9e7fd08c6acec629cb1a16bc697cedfd846548"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11117 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11117""}]"	""
pathwaymech:GO_0042864_pch-edge-084_2f7fd6526a51	MetaCyc:RXN-19466	RO:0002413	MetaCyc:RXN-19469	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-19466|MetaCyc:RXN-19469		"[{""reference_id"": ""MetaCyc:RXN-19466"", ""source_assertion"": ""The original product side contains Salicyl-PchE; the subsequent reaction consumes that same source-native intermediate."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-19466\""]/right[*/@frameid=\""Salicyl-PchE\""]""}, {""reference_id"": ""MetaCyc:RXN-19469"", ""source_assertion"": ""The original substrate side contains Salicyl-PchE; this supplies the second half of the intermediate bridge."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-19469\""]/left[*/@frameid=\""Salicyl-PchE\""]""}]"	"[{""id"": ""MetaCyc:RXN-19466"", ""source_sha256"": ""90b5b1326fbdd0bf342f808bf9107665ab0bd1afe37abf2329112023a479e9d0"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-19466 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19466""}, {""id"": ""MetaCyc:RXN-19469"", ""source_sha256"": ""3dee7e8cac6b071cabc7022b8aecdab4418857a9af5fb2e79c258f31f262856e"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-19469 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19469""}]"	""
pathwaymech:GO_0042864_pch-edge-085_bc81305493bd	MetaCyc:RXN-11125	RO:0002413	MetaCyc:RXN-19469	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11125|MetaCyc:RXN-19469		"[{""reference_id"": ""MetaCyc:RXN-11125"", ""source_assertion"": ""The original product side contains L-cysteinyl-PchE; the subsequent reaction consumes that same source-native intermediate."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11125\""]/right[*/@frameid=\""L-cysteinyl-PchE\""]""}, {""reference_id"": ""MetaCyc:RXN-19469"", ""source_assertion"": ""The original substrate side contains L-cysteinyl-PchE; this supplies the second half of the intermediate bridge."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-19469\""]/left[*/@frameid=\""L-cysteinyl-PchE\""]""}]"	"[{""id"": ""MetaCyc:RXN-11125"", ""source_sha256"": ""1bb527f849d8a433ac02a48213db1dbbf24dc92b2c3fc7e1f0dec4166590d09e"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11125 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11125""}, {""id"": ""MetaCyc:RXN-19469"", ""source_sha256"": ""3dee7e8cac6b071cabc7022b8aecdab4418857a9af5fb2e79c258f31f262856e"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-19469 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19469""}]"	""
pathwaymech:GO_0042864_pch-edge-086_9aa4ffcba7b4	MetaCyc:RXN-19469	RO:0002413	MetaCyc:RXN-11118	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11118|MetaCyc:RXN-19469		"[{""reference_id"": ""MetaCyc:RXN-19469"", ""source_assertion"": ""The original product side contains Salicyl-L-cysteinyl-PchE; the subsequent reaction consumes that same source-native intermediate."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-19469\""]/right[*/@frameid=\""Salicyl-L-cysteinyl-PchE\""]""}, {""reference_id"": ""MetaCyc:RXN-11118"", ""source_assertion"": ""The original substrate side contains Salicyl-L-cysteinyl-PchE; this supplies the second half of the intermediate bridge."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11118\""]/left[*/@frameid=\""Salicyl-L-cysteinyl-PchE\""]""}]"	"[{""id"": ""MetaCyc:RXN-11118"", ""source_sha256"": ""ed597e122d42856b809477bbbece65a904af1b39677b1a5193834347c8b184c6"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11118 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11118""}, {""id"": ""MetaCyc:RXN-19469"", ""source_sha256"": ""3dee7e8cac6b071cabc7022b8aecdab4418857a9af5fb2e79c258f31f262856e"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-19469 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19469""}]"	""
pathwaymech:GO_0042864_pch-edge-087_d07d8b47b1bd	MetaCyc:RXN-11118	RO:0002413	MetaCyc:RXN-11120	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11118|MetaCyc:RXN-11120		"[{""reference_id"": ""MetaCyc:RXN-11118"", ""source_assertion"": ""The original product side contains hydroxyphenyl-thiazolinyl-PchE; the subsequent reaction consumes that same source-native intermediate."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11118\""]/right[*/@frameid=\""hydroxyphenyl-thiazolinyl-PchE\""]""}, {""reference_id"": ""MetaCyc:RXN-11120"", ""source_assertion"": ""The original substrate side contains hydroxyphenyl-thiazolinyl-PchE; this supplies the second half of the intermediate bridge."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11120\""]/left[*/@frameid=\""hydroxyphenyl-thiazolinyl-PchE\""]""}]"	"[{""id"": ""MetaCyc:RXN-11118"", ""source_sha256"": ""ed597e122d42856b809477bbbece65a904af1b39677b1a5193834347c8b184c6"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11118 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11118""}, {""id"": ""MetaCyc:RXN-11120"", ""source_sha256"": ""46561ff8f4705b28853f5720c5d18d0d3088de9767a169a25bef7324567bb3c4"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11120 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11120""}]"	""
pathwaymech:GO_0042864_pch-edge-088_d3eec7213f91	MetaCyc:RXN-11117	RO:0002413	MetaCyc:RXN-11120	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11117|MetaCyc:RXN-11120		"[{""reference_id"": ""MetaCyc:RXN-11117"", ""source_assertion"": ""The original product side contains L-cysteinyl-PchF; the subsequent reaction consumes that same source-native intermediate."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11117\""]/right[*/@frameid=\""L-cysteinyl-PchF\""]""}, {""reference_id"": ""MetaCyc:RXN-11120"", ""source_assertion"": ""The original substrate side contains L-cysteinyl-PchF; this supplies the second half of the intermediate bridge."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11120\""]/left[*/@frameid=\""L-cysteinyl-PchF\""]""}]"	"[{""id"": ""MetaCyc:RXN-11117"", ""source_sha256"": ""397e1a01575feef9f7d0e3743d9e7fd08c6acec629cb1a16bc697cedfd846548"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11117 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11117""}, {""id"": ""MetaCyc:RXN-11120"", ""source_sha256"": ""46561ff8f4705b28853f5720c5d18d0d3088de9767a169a25bef7324567bb3c4"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11120 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11120""}]"	""
pathwaymech:GO_0042864_pch-edge-089_03132007aa0b	MetaCyc:RXN-11120	RO:0002413	MetaCyc:RXN-11121	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11120|MetaCyc:RXN-11121		"[{""reference_id"": ""MetaCyc:RXN-11120"", ""source_assertion"": ""The original product side contains Hydroxyphenyl-bis-thiazolinyl-PchF; the subsequent reaction consumes that same source-native intermediate."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11120\""]/right[*/@frameid=\""Hydroxyphenyl-bis-thiazolinyl-PchF\""]""}, {""reference_id"": ""MetaCyc:RXN-11121"", ""source_assertion"": ""The original substrate side contains Hydroxyphenyl-bis-thiazolinyl-PchF; this supplies the second half of the intermediate bridge."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11121\""]/left[*/@frameid=\""Hydroxyphenyl-bis-thiazolinyl-PchF\""]""}]"	"[{""id"": ""MetaCyc:RXN-11120"", ""source_sha256"": ""46561ff8f4705b28853f5720c5d18d0d3088de9767a169a25bef7324567bb3c4"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11120 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11120""}, {""id"": ""MetaCyc:RXN-11121"", ""source_sha256"": ""62bc4169f543309b8fa0b35885fb5158e0203e356c72cc75f86a62d5c4dcfd44"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11121 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11121""}]"	""
pathwaymech:GO_0042864_pch-edge-090_5345f69084e4	MetaCyc:RXN-11121	RO:0002413	MetaCyc:RXN-11122	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11121|MetaCyc:RXN-11122		"[{""reference_id"": ""MetaCyc:RXN-11121"", ""source_assertion"": ""The original product side contains N-desmethyl-pyochelin-PchF; the subsequent reaction consumes that same source-native intermediate."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11121\""]/right[*/@frameid=\""N-desmethyl-pyochelin-PchF\""]""}, {""reference_id"": ""MetaCyc:RXN-11122"", ""source_assertion"": ""The original substrate side contains N-desmethyl-pyochelin-PchF; this supplies the second half of the intermediate bridge."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11122\""]/left[*/@frameid=\""N-desmethyl-pyochelin-PchF\""]""}]"	"[{""id"": ""MetaCyc:RXN-11121"", ""source_sha256"": ""62bc4169f543309b8fa0b35885fb5158e0203e356c72cc75f86a62d5c4dcfd44"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11121 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11121""}, {""id"": ""MetaCyc:RXN-11122"", ""source_sha256"": ""b6ac9eef8c0f9508fc844fc55516dbdf105599fcbe3a51821c25c5f08774af9f"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11122 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11122""}]"	""
pathwaymech:GO_0042864_pch-edge-091_c73356d95fa9	MetaCyc:RXN-11122	RO:0002413	MetaCyc:RXN-11123	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-11122|MetaCyc:RXN-11123		"[{""reference_id"": ""MetaCyc:RXN-11122"", ""source_assertion"": ""The original product side contains Pyochelinyl-PchF; the subsequent reaction consumes that same source-native intermediate."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11122\""]/right[*/@frameid=\""Pyochelinyl-PchF\""]""}, {""reference_id"": ""MetaCyc:RXN-11123"", ""source_assertion"": ""The original substrate side contains Pyochelinyl-PchF; this supplies the second half of the intermediate bridge."", ""source_locator"": ""ptools-xml/Reaction[@frameid=\""RXN-11123\""]/left[*/@frameid=\""Pyochelinyl-PchF\""]""}]"	"[{""id"": ""MetaCyc:RXN-11122"", ""source_sha256"": ""b6ac9eef8c0f9508fc844fc55516dbdf105599fcbe3a51821c25c5f08774af9f"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11122 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11122""}, {""id"": ""MetaCyc:RXN-11123"", ""source_sha256"": ""e3fbb29993d18b3d93a5ca0a4114e6c3fb3ad53d3d2244d7099023623000d0a7"", ""source_version"": ""Original MetaCyc 22.5 native XML; retrieved 2026-10-11; digest covers complete original response"", ""title"": ""MetaCyc RXN-11123 original native frame"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11123""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-001_b6d89b2cfc70	CHEBI:15377	pathwaymech:consumes	RHEA:12057	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12057		"[{""reference_id"": ""RHEA:12057"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:12057 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12057']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12057"", ""source_version"": ""139"", ""title"": ""Rhea 4-phospho-D-erythronate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12057""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-002_31980fad30fe	CHEBI:16897	pathwaymech:consumes	RHEA:12057	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12057		"[{""reference_id"": ""RHEA:12057"", ""source_assertion"": ""Rhea lists CHEBI:16897 on the substrates side of RHEA:12057 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12057']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12057"", ""source_version"": ""139"", ""title"": ""Rhea 4-phospho-D-erythronate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12057""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-003_9bb179697825	CHEBI:57540	pathwaymech:consumes	RHEA:12057	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12057		"[{""reference_id"": ""RHEA:12057"", ""source_assertion"": ""Rhea lists CHEBI:57540 on the substrates side of RHEA:12057 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12057']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12057"", ""source_version"": ""139"", ""title"": ""Rhea 4-phospho-D-erythronate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12057""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-004_c2b45fd99a17	RHEA:12057	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12057		"[{""reference_id"": ""RHEA:12057"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:12057 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12057']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12057"", ""source_version"": ""139"", ""title"": ""Rhea 4-phospho-D-erythronate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12057""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-005_11eea058e6cc	RHEA:12057	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12057		"[{""reference_id"": ""RHEA:12057"", ""source_assertion"": ""Rhea lists CHEBI:57945 on the products side of RHEA:12057 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12057']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12057"", ""source_version"": ""139"", ""title"": ""Rhea 4-phospho-D-erythronate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12057""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-006_47fae2b08dc6	RHEA:12057	pathwaymech:produces	CHEBI:58766	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12057		"[{""reference_id"": ""RHEA:12057"", ""source_assertion"": ""Rhea lists CHEBI:58766 on the products side of RHEA:12057 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12057']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12057"", ""source_version"": ""139"", ""title"": ""Rhea 4-phospho-D-erythronate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12057""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-007_0f3ea7a1ff81	CHEBI:57540	pathwaymech:consumes	RHEA:18830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18830		"[{""reference_id"": ""RHEA:18830"", ""source_assertion"": ""Rhea lists CHEBI:57540 on the substrates side of RHEA:18830 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18830']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18830"", ""source_version"": ""139"", ""title"": ""Rhea (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18830""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-008_3a3352c91cc8	CHEBI:58766	pathwaymech:consumes	RHEA:18830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18830		"[{""reference_id"": ""RHEA:18830"", ""source_assertion"": ""Rhea lists CHEBI:58766 on the substrates side of RHEA:18830 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18830']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18830"", ""source_version"": ""139"", ""title"": ""Rhea (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18830""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-009_3612080007de	RHEA:18830	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18830		"[{""reference_id"": ""RHEA:18830"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:18830 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18830']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18830"", ""source_version"": ""139"", ""title"": ""Rhea (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18830""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-010_ed1f1870f1bd	RHEA:18830	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18830		"[{""reference_id"": ""RHEA:18830"", ""source_assertion"": ""Rhea lists CHEBI:57945 on the products side of RHEA:18830 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18830']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18830"", ""source_version"": ""139"", ""title"": ""Rhea (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18830""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-011_ae1ceee7451c	RHEA:18830	pathwaymech:produces	CHEBI:58538	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18830		"[{""reference_id"": ""RHEA:18830"", ""source_assertion"": ""Rhea lists CHEBI:58538 on the products side of RHEA:18830 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18830']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18830"", ""source_version"": ""139"", ""title"": ""Rhea (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18830""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-012_0023fd8404ca	CHEBI:29985	pathwaymech:consumes	RHEA:16575	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16575		"[{""reference_id"": ""RHEA:16575"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the substrates side of RHEA:16575 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16575']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16575"", ""source_version"": ""139"", ""title"": ""Rhea 4-(phosphooxy)-L-threonine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16575""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-013_bc53be738e31	CHEBI:58538	pathwaymech:consumes	RHEA:16575	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16575		"[{""reference_id"": ""RHEA:16575"", ""source_assertion"": ""Rhea lists CHEBI:58538 on the substrates side of RHEA:16575 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16575']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16575"", ""source_version"": ""139"", ""title"": ""Rhea 4-(phosphooxy)-L-threonine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16575""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-014_e678431d74d5	RHEA:16575	pathwaymech:produces	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16575		"[{""reference_id"": ""RHEA:16575"", ""source_assertion"": ""Rhea lists CHEBI:16810 on the products side of RHEA:16575 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16575']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16575"", ""source_version"": ""139"", ""title"": ""Rhea 4-(phosphooxy)-L-threonine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16575""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-015_97d22f8cb790	RHEA:16575	pathwaymech:produces	CHEBI:58452	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16575		"[{""reference_id"": ""RHEA:16575"", ""source_assertion"": ""Rhea lists CHEBI:58452 on the products side of RHEA:16575 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16575']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:16575"", ""source_version"": ""139"", ""title"": ""Rhea 4-(phosphooxy)-L-threonine-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/16575""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-016_f00a92cd86e2	CHEBI:57540	pathwaymech:consumes	RHEA:32276	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:32276		"[{""reference_id"": ""RHEA:32276"", ""source_assertion"": ""Rhea lists CHEBI:57540 on the substrates side of RHEA:32276 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/32276']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:32276"", ""source_version"": ""139"", ""title"": ""Rhea 3-amino-2-oxopropyl phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/32276""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-017_29781ddcb4f3	CHEBI:58452	pathwaymech:consumes	RHEA:32276	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:32276		"[{""reference_id"": ""RHEA:32276"", ""source_assertion"": ""Rhea lists CHEBI:58452 on the substrates side of RHEA:32276 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/32276']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:32276"", ""source_version"": ""139"", ""title"": ""Rhea 3-amino-2-oxopropyl phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/32276""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-018_8e8e5575e39c	RHEA:32276	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:32276		"[{""reference_id"": ""RHEA:32276"", ""source_assertion"": ""Rhea lists CHEBI:16526 on the products side of RHEA:32276 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/32276']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:32276"", ""source_version"": ""139"", ""title"": ""Rhea 3-amino-2-oxopropyl phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/32276""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-019_a7c5b2b4e972	RHEA:32276	pathwaymech:produces	CHEBI:57279	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:32276		"[{""reference_id"": ""RHEA:32276"", ""source_assertion"": ""Rhea lists CHEBI:57279 on the products side of RHEA:32276 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/32276']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:32276"", ""source_version"": ""139"", ""title"": ""Rhea 3-amino-2-oxopropyl phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/32276""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-020_1e852beded42	RHEA:32276	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:32276		"[{""reference_id"": ""RHEA:32276"", ""source_assertion"": ""Rhea lists CHEBI:57945 on the products side of RHEA:32276 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/32276']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:32276"", ""source_version"": ""139"", ""title"": ""Rhea 3-amino-2-oxopropyl phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/32276""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-021_509bb88f9d49	CHEBI:15361	pathwaymech:consumes	RHEA:12606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12606		"[{""reference_id"": ""RHEA:12606"", ""source_assertion"": ""Rhea lists CHEBI:15361 on the substrates side of RHEA:12606 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12606']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12606"", ""source_version"": ""139"", ""title"": ""Rhea 1-deoxy-D-xylulose 5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12606""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-022_4661ab7a9243	CHEBI:15378	pathwaymech:consumes	RHEA:12606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12606		"[{""reference_id"": ""RHEA:12606"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:12606 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12606']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12606"", ""source_version"": ""139"", ""title"": ""Rhea 1-deoxy-D-xylulose 5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12606""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-023_330168aa8c76	CHEBI:59776	pathwaymech:consumes	RHEA:12606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12606		"[{""reference_id"": ""RHEA:12606"", ""source_assertion"": ""Rhea lists CHEBI:59776 on the substrates side of RHEA:12606 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12606']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12606"", ""source_version"": ""139"", ""title"": ""Rhea 1-deoxy-D-xylulose 5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12606""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-024_03d4fcf5b464	RHEA:12606	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12606		"[{""reference_id"": ""RHEA:12606"", ""source_assertion"": ""Rhea lists CHEBI:16526 on the products side of RHEA:12606 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12606']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12606"", ""source_version"": ""139"", ""title"": ""Rhea 1-deoxy-D-xylulose 5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12606""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-025_ed7f1c87974a	RHEA:12606	pathwaymech:produces	CHEBI:57792	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12606		"[{""reference_id"": ""RHEA:12606"", ""source_assertion"": ""Rhea lists CHEBI:57792 on the products side of RHEA:12606 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/12606']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:12606"", ""source_version"": ""139"", ""title"": ""Rhea 1-deoxy-D-xylulose 5-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/12606""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-026_2dbc71e57b2b	CHEBI:57279	pathwaymech:consumes	RHEA:15266	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15266		"[{""reference_id"": ""RHEA:15266"", ""source_assertion"": ""Rhea lists CHEBI:57279 on the substrates side of RHEA:15266 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15266']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15266"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15266""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-027_52f25685601f	CHEBI:57792	pathwaymech:consumes	RHEA:15266	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15266		"[{""reference_id"": ""RHEA:15266"", ""source_assertion"": ""Rhea lists CHEBI:57792 on the substrates side of RHEA:15266 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15266']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15266"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15266""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-028_925f9a41718d	RHEA:15266	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15266		"[{""reference_id"": ""RHEA:15266"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:15266 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15266']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15266"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15266""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-029_b6d7c6077517	RHEA:15266	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15266		"[{""reference_id"": ""RHEA:15266"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:15266 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15266']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15266"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15266""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-030_1f6786f8d714	RHEA:15266	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15266		"[{""reference_id"": ""RHEA:15266"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:15266 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15266']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15266"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15266""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-031_cbffae155fcd	RHEA:15266	pathwaymech:produces	CHEBI:58589	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15266		"[{""reference_id"": ""RHEA:15266"", ""source_assertion"": ""Rhea lists CHEBI:58589 on the products side of RHEA:15266 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15266']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15266"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15266""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-032_469148715efc	CHEBI:15379	pathwaymech:consumes	RHEA:15150	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15150		"[{""reference_id"": ""RHEA:15150"", ""source_assertion"": ""Rhea lists CHEBI:15379 on the substrates side of RHEA:15150 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15150']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15150"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15150""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-033_81362230459e	CHEBI:58589	pathwaymech:consumes	RHEA:15150	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15150		"[{""reference_id"": ""RHEA:15150"", ""source_assertion"": ""Rhea lists CHEBI:58589 on the substrates side of RHEA:15150 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15150']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15150"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15150""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-034_1d4a82f5cdfd	RHEA:15150	pathwaymech:produces	CHEBI:16240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15150		"[{""reference_id"": ""RHEA:15150"", ""source_assertion"": ""Rhea lists CHEBI:16240 on the products side of RHEA:15150 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15150']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15150"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15150""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-035_6a9b669d497d	RHEA:15150	pathwaymech:produces	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15150		"[{""reference_id"": ""RHEA:15150"", ""source_assertion"": ""Rhea lists CHEBI:597326 on the products side of RHEA:15150 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15150']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15150"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/15150""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-036_4e234ba3fdf2	EC:1.2.1.72	pathwaymech:catalyzes	RHEA:12057	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12056		"[{""reference_id"": ""RHEA:12056"", ""source_assertion"": ""Rhea associates EC:1.2.1.72 with the reaction family containing RHEA:12057."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:12056"", ""source_version"": ""139"", ""title"": ""Rhea erythrose-4-phosphate dehydrogenase reaction"", ""url"": ""https://www.rhea-db.org/rhea/12056""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-037_d0354cbceee9	EC:1.1.1.290	pathwaymech:catalyzes	RHEA:18830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18829		"[{""reference_id"": ""RHEA:18829"", ""source_assertion"": ""Rhea associates EC:1.1.1.290 with the reaction family containing RHEA:18830."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:18829"", ""source_version"": ""139"", ""title"": ""Rhea 4-phospho-D-erythronate dehydrogenase reaction"", ""url"": ""https://www.rhea-db.org/rhea/18829""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-038_5a427b8ec7d5	EC:2.6.1.52	pathwaymech:catalyzes	RHEA:16575	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16573		"[{""reference_id"": ""RHEA:16573"", ""source_assertion"": ""Rhea associates EC:2.6.1.52 with the reaction family containing RHEA:16575."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:16573"", ""source_version"": ""139"", ""title"": ""Rhea phosphoserine transaminase reaction"", ""url"": ""https://www.rhea-db.org/rhea/16573""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-039_98e21b0df12e	EC:1.1.1.262	pathwaymech:catalyzes	RHEA:32276	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:32275		"[{""reference_id"": ""RHEA:32275"", ""source_assertion"": ""Rhea associates EC:1.1.1.262 with the reaction family containing RHEA:32276."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:32275"", ""source_version"": ""139"", ""title"": ""Rhea 4-hydroxythreonine-4-phosphate dehydrogenase reaction"", ""url"": ""https://www.rhea-db.org/rhea/32275""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-040_f0c5869e9de4	EC:2.2.1.7	pathwaymech:catalyzes	RHEA:12606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12605		"[{""reference_id"": ""RHEA:12605"", ""source_assertion"": ""Rhea associates EC:2.2.1.7 with the reaction family containing RHEA:12606."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:12605"", ""source_version"": ""139"", ""title"": ""Rhea 1-deoxy-D-xylulose-5-phosphate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/12605""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-041_c303332aaa1e	EC:2.6.99.2	pathwaymech:catalyzes	RHEA:15266	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15265		"[{""reference_id"": ""RHEA:15265"", ""source_assertion"": ""Rhea associates EC:2.6.99.2 with the reaction family containing RHEA:15266."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:15265"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxine 5'-phosphate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/15265""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-042_94e13f822a1a	EC:1.4.3.5	pathwaymech:catalyzes	RHEA:15150	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15149		"[{""reference_id"": ""RHEA:15149"", ""source_assertion"": ""Rhea associates EC:1.4.3.5 with the reaction family containing RHEA:15150."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:15149"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxine 5'-phosphate oxidase reaction"", ""url"": ""https://www.rhea-db.org/rhea/15149""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-043_22f69a71858a	RHEA:12057	pathwaymech:precedes	RHEA:18830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PYRIDOXSYN-PWY		"[{""reference_id"": ""MetaCyc:PYRIDOXSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:12057 before RHEA:18830 in this pathway. Shared intermediate: CHEBI:58766."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PYRIDOXSYN-PWY"", ""source_sha256"": ""a99e480899e85e0631ad7de6ad9d4800f621b7d3b2fb75fe70567901a84be580"", ""source_version"": ""22.5"", ""title"": ""MetaCyc pyridoxal 5'-phosphate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PYRIDOXSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-044_5ac266c627d7	RHEA:12606	pathwaymech:precedes	RHEA:15266	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PYRIDOXSYN-PWY		"[{""reference_id"": ""MetaCyc:PYRIDOXSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:12606 before RHEA:15266 in this pathway. Shared intermediate: CHEBI:57792."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PYRIDOXSYN-PWY"", ""source_sha256"": ""a99e480899e85e0631ad7de6ad9d4800f621b7d3b2fb75fe70567901a84be580"", ""source_version"": ""22.5"", ""title"": ""MetaCyc pyridoxal 5'-phosphate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PYRIDOXSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-045_9995fbe9fcbb	RHEA:15266	pathwaymech:precedes	RHEA:15150	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PYRIDOXSYN-PWY		"[{""reference_id"": ""MetaCyc:PYRIDOXSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:15266 before RHEA:15150 in this pathway. Shared intermediate: CHEBI:58589."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PYRIDOXSYN-PWY"", ""source_sha256"": ""a99e480899e85e0631ad7de6ad9d4800f621b7d3b2fb75fe70567901a84be580"", ""source_version"": ""22.5"", ""title"": ""MetaCyc pyridoxal 5'-phosphate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PYRIDOXSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-046_e3ceae1a7aca	RHEA:16575	pathwaymech:precedes	RHEA:32276	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PYRIDOXSYN-PWY		"[{""reference_id"": ""MetaCyc:PYRIDOXSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:16575 before RHEA:32276 in this pathway. Shared intermediate: CHEBI:58452."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PYRIDOXSYN-PWY"", ""source_sha256"": ""a99e480899e85e0631ad7de6ad9d4800f621b7d3b2fb75fe70567901a84be580"", ""source_version"": ""22.5"", ""title"": ""MetaCyc pyridoxal 5'-phosphate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PYRIDOXSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-047_cb49eecdfb32	RHEA:18830	pathwaymech:precedes	RHEA:16575	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PYRIDOXSYN-PWY		"[{""reference_id"": ""MetaCyc:PYRIDOXSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:18830 before RHEA:16575 in this pathway. Shared intermediate: CHEBI:58538."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PYRIDOXSYN-PWY"", ""source_sha256"": ""a99e480899e85e0631ad7de6ad9d4800f621b7d3b2fb75fe70567901a84be580"", ""source_version"": ""22.5"", ""title"": ""MetaCyc pyridoxal 5'-phosphate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PYRIDOXSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-048_5222b183f051	RHEA:32276	pathwaymech:precedes	RHEA:15266	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PYRIDOXSYN-PWY		"[{""reference_id"": ""MetaCyc:PYRIDOXSYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:32276 before RHEA:15266 in this pathway. Shared intermediate: CHEBI:57279."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PYRIDOXSYN-PWY"", ""source_sha256"": ""a99e480899e85e0631ad7de6ad9d4800f621b7d3b2fb75fe70567901a84be580"", ""source_version"": ""22.5"", ""title"": ""MetaCyc pyridoxal 5'-phosphate biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PYRIDOXSYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-049_f18ac4c50f23	UniProtKB:P05459	pathwaymech:enables	RHEA:18830	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05459		"[{""reference_id"": ""UniProtKB:P05459"", ""source_assertion"": ""UniProt annotates UniProtKB:P05459 with catalytic activity for the reaction family of RHEA:18830. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P05459"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05459 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05459.json""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-050_a6c828553813	UniProtKB:P05459	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05459		"[{""reference_id"": ""UniProtKB:P05459"", ""source_assertion"": ""UniProt locates UniProtKB:P05459 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P05459"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05459 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05459.json""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-051_726b160bd6a7	UniProtKB:P0A794	pathwaymech:enables	RHEA:15266	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A794		"[{""reference_id"": ""UniProtKB:P0A794"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A794 with catalytic activity for the reaction family of RHEA:15266. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A794"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A794 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A794.json""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-052_5c9c66b1a017	UniProtKB:P0A794	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A794		"[{""reference_id"": ""UniProtKB:P0A794"", ""source_assertion"": ""UniProt locates UniProtKB:P0A794 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A794"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A794 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A794.json""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-053_57579e21d927	UniProtKB:P0A9B6	pathwaymech:enables	RHEA:12057	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9B6		"[{""reference_id"": ""UniProtKB:P0A9B6"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A9B6 with catalytic activity for the reaction family of RHEA:12057. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A9B6"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9B6 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9B6.json""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-054_69c79ae67263	UniProtKB:P0A9B6	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A9B6		"[{""reference_id"": ""UniProtKB:P0A9B6"", ""source_assertion"": ""UniProt locates UniProtKB:P0A9B6 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A9B6"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A9B6 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9B6.json""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-055_9727ed97cbcc	UniProtKB:P0AFI7	pathwaymech:enables	RHEA:15150	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AFI7		"[{""reference_id"": ""UniProtKB:P0AFI7"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AFI7 with catalytic activity for the reaction family of RHEA:15150. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AFI7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AFI7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AFI7.json""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-056_5f9f1bd6ab36	UniProtKB:P0AFI7	pathwaymech:has_cofactor	CHEBI:58210	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AFI7		"[{""reference_id"": ""UniProtKB:P0AFI7"", ""source_assertion"": ""UniProt lists CHEBI:58210 as a cofactor of UniProtKB:P0AFI7 (evidence: ECO:0000269). Binds 1 FMN per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AFI7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AFI7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AFI7.json""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-057_4fc4022804f6	UniProtKB:P19624	pathwaymech:enables	RHEA:32276	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P19624		"[{""reference_id"": ""UniProtKB:P19624"", ""source_assertion"": ""UniProt annotates UniProtKB:P19624 with catalytic activity for the reaction family of RHEA:32276. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P19624"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P19624 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P19624.json""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-058_c2f241adb919	UniProtKB:P19624	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P19624		"[{""reference_id"": ""UniProtKB:P19624"", ""source_assertion"": ""UniProt locates UniProtKB:P19624 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: ECO:0000255."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P19624"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P19624 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P19624.json""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-059_e93e1c5500c9	UniProtKB:P19624	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P19624		"[{""reference_id"": ""UniProtKB:P19624"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P19624 (evidence: ECO:0000255, ECO:0000269). Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P19624"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P19624 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P19624.json""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-060_cb567901c7a7	UniProtKB:P19624	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P19624		"[{""reference_id"": ""UniProtKB:P19624"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P19624 (evidence: ECO:0000255, ECO:0000269). Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P19624"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P19624 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P19624.json""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-061_b75f9887bda8	UniProtKB:P19624	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P19624		"[{""reference_id"": ""UniProtKB:P19624"", ""source_assertion"": ""UniProt lists CHEBI:48828 as a cofactor of UniProtKB:P19624 (evidence: ECO:0000255, ECO:0000269). Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P19624"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P19624 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P19624.json""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-062_6bb84bbc5614	UniProtKB:P23721	pathwaymech:enables	RHEA:16575	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23721		"[{""reference_id"": ""UniProtKB:P23721"", ""source_assertion"": ""UniProt annotates UniProtKB:P23721 with catalytic activity for the reaction family of RHEA:16575. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P23721"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P23721 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23721.json""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-063_2268504979d2	UniProtKB:P23721	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23721		"[{""reference_id"": ""UniProtKB:P23721"", ""source_assertion"": ""UniProt locates UniProtKB:P23721 in Cytoplasm (SL-0086, mapped by UniProt to GO:0005737). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P23721"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P23721 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23721.json""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-064_3ca1a6dfa0b8	UniProtKB:P23721	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23721		"[{""reference_id"": ""UniProtKB:P23721"", ""source_assertion"": ""UniProt lists CHEBI:597326 as a cofactor of UniProtKB:P23721 (evidence: ECO:0000269). Binds 1 pyridoxal phosphate per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P23721"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P23721 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23721.json""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-065_db56880600d5	UniProtKB:P77488	pathwaymech:enables	RHEA:12606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77488		"[{""reference_id"": ""UniProtKB:P77488"", ""source_assertion"": ""UniProt annotates UniProtKB:P77488 with catalytic activity for the reaction family of RHEA:12606. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P77488"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P77488 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77488.json""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-066_20ba55556d54	UniProtKB:P77488	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77488		"[{""reference_id"": ""UniProtKB:P77488"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P77488 (evidence: ECO:0000269). Binds 1 Mg(2+) ion per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P77488"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P77488 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77488.json""}]"	""
pathwaymech:MetaCyc_PYRIDOXSYN-PWY_edge-067_4bc49c554746	UniProtKB:P77488	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77488		"[{""reference_id"": ""UniProtKB:P77488"", ""source_assertion"": ""UniProt lists CHEBI:58937 as a cofactor of UniProtKB:P77488 (evidence: ECO:0000269). Binds 1 thiamine pyrophosphate per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P77488"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P77488 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77488.json""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-001_ccc923b67476	CHEBI:17310	pathwaymech:consumes	RHEA:10225	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10225		"[{""reference_id"": ""RHEA:10225"", ""source_assertion"": ""Rhea lists CHEBI:17310 on the substrates side of RHEA:10225 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10225']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10225"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10225""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-002_8cddfc0fd916	CHEBI:30616	pathwaymech:consumes	RHEA:10225	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10225		"[{""reference_id"": ""RHEA:10225"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:10225 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10225']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10225"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10225""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-003_f1413345cb5d	RHEA:10225	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10225		"[{""reference_id"": ""RHEA:10225"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:10225 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10225']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10225"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10225""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-004_7f8cca21e0e2	RHEA:10225	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10225		"[{""reference_id"": ""RHEA:10225"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:10225 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10225']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10225"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10225""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-005_728c9534d6fa	RHEA:10225	pathwaymech:produces	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10225		"[{""reference_id"": ""RHEA:10225"", ""source_assertion"": ""Rhea lists CHEBI:597326 on the products side of RHEA:10225 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10225']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10225"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10225""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-006_73f46bb99297	CHEBI:30616	pathwaymech:consumes	RHEA:25105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25105		"[{""reference_id"": ""RHEA:25105"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:25105 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25105']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25105"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxamine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25105""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-007_0c988c408251	CHEBI:57761	pathwaymech:consumes	RHEA:25105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25105		"[{""reference_id"": ""RHEA:25105"", ""source_assertion"": ""Rhea lists CHEBI:57761 on the substrates side of RHEA:25105 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25105']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25105"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxamine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25105""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-008_652b623c9acd	RHEA:25105	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25105		"[{""reference_id"": ""RHEA:25105"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:25105 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25105']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25105"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxamine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25105""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-009_17b8ad7fd8ca	RHEA:25105	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25105		"[{""reference_id"": ""RHEA:25105"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:25105 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25105']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25105"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxamine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25105""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-010_739f7f3e62c2	RHEA:25105	pathwaymech:produces	CHEBI:58451	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25105		"[{""reference_id"": ""RHEA:25105"", ""source_assertion"": ""Rhea lists CHEBI:58451 on the products side of RHEA:25105 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25105']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25105"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxamine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25105""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-011_cc07adb6a14d	CHEBI:15377	pathwaymech:consumes	RHEA:15818	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15818		"[{""reference_id"": ""RHEA:15818"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:15818 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15818']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15818"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming pyridoxamine oxidase direction"", ""url"": ""https://www.rhea-db.org/rhea/15818""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-012_a6159d978a03	CHEBI:15379	pathwaymech:consumes	RHEA:15818	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15818		"[{""reference_id"": ""RHEA:15818"", ""source_assertion"": ""Rhea lists CHEBI:15379 on the substrates side of RHEA:15818 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15818']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15818"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming pyridoxamine oxidase direction"", ""url"": ""https://www.rhea-db.org/rhea/15818""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-013_974a6e448429	CHEBI:58451	pathwaymech:consumes	RHEA:15818	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15818		"[{""reference_id"": ""RHEA:15818"", ""source_assertion"": ""Rhea lists CHEBI:58451 on the substrates side of RHEA:15818 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15818']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15818"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming pyridoxamine oxidase direction"", ""url"": ""https://www.rhea-db.org/rhea/15818""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-014_db50965f35c4	RHEA:15818	pathwaymech:produces	CHEBI:16240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15818		"[{""reference_id"": ""RHEA:15818"", ""source_assertion"": ""Rhea lists CHEBI:16240 on the products side of RHEA:15818 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15818']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15818"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming pyridoxamine oxidase direction"", ""url"": ""https://www.rhea-db.org/rhea/15818""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-015_88d202cee752	RHEA:15818	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15818		"[{""reference_id"": ""RHEA:15818"", ""source_assertion"": ""Rhea lists CHEBI:28938 on the products side of RHEA:15818 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15818']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15818"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming pyridoxamine oxidase direction"", ""url"": ""https://www.rhea-db.org/rhea/15818""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-016_bf74e16b8174	RHEA:15818	pathwaymech:produces	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15818		"[{""reference_id"": ""RHEA:15818"", ""source_assertion"": ""Rhea lists CHEBI:597326 on the products side of RHEA:15818 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15818']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15818"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming pyridoxamine oxidase direction"", ""url"": ""https://www.rhea-db.org/rhea/15818""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-017_42d640262f01	CHEBI:16709	pathwaymech:consumes	RHEA:25109	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25109		"[{""reference_id"": ""RHEA:25109"", ""source_assertion"": ""Rhea lists CHEBI:16709 on the substrates side of RHEA:25109 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25109']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25109"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25109""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-018_5d5599cc01b3	CHEBI:30616	pathwaymech:consumes	RHEA:25109	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25109		"[{""reference_id"": ""RHEA:25109"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:25109 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25109']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25109"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25109""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-019_a8beeb8ce89e	RHEA:25109	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25109		"[{""reference_id"": ""RHEA:25109"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:25109 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25109']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25109"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25109""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-020_c5e979f794df	RHEA:25109	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25109		"[{""reference_id"": ""RHEA:25109"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:25109 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25109']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25109"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25109""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-021_a6aae7e4323e	RHEA:25109	pathwaymech:produces	CHEBI:58589	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25109		"[{""reference_id"": ""RHEA:25109"", ""source_assertion"": ""Rhea lists CHEBI:58589 on the products side of RHEA:25109 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/25109']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:25109"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/25109""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-022_09ddc0231727	CHEBI:15379	pathwaymech:consumes	RHEA:15150	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15150		"[{""reference_id"": ""RHEA:15150"", ""source_assertion"": ""Rhea lists CHEBI:15379 on the substrates side of RHEA:15150 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15150']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15150"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming pyridoxine oxidase direction"", ""url"": ""https://www.rhea-db.org/rhea/15150""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-023_4fff8fbb676f	CHEBI:58589	pathwaymech:consumes	RHEA:15150	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15150		"[{""reference_id"": ""RHEA:15150"", ""source_assertion"": ""Rhea lists CHEBI:58589 on the substrates side of RHEA:15150 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15150']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15150"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming pyridoxine oxidase direction"", ""url"": ""https://www.rhea-db.org/rhea/15150""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-024_25bf60cf5991	RHEA:15150	pathwaymech:produces	CHEBI:16240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15150		"[{""reference_id"": ""RHEA:15150"", ""source_assertion"": ""Rhea lists CHEBI:16240 on the products side of RHEA:15150 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15150']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15150"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming pyridoxine oxidase direction"", ""url"": ""https://www.rhea-db.org/rhea/15150""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-025_9bcc8b18d052	RHEA:15150	pathwaymech:produces	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15150		"[{""reference_id"": ""RHEA:15150"", ""source_assertion"": ""Rhea lists CHEBI:597326 on the products side of RHEA:15150 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/15150']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:15150"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal 5'-phosphate-forming pyridoxine oxidase direction"", ""url"": ""https://www.rhea-db.org/rhea/15150""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-026_26e94f05e086	EC:2.7.1.35	pathwaymech:catalyzes	RHEA:10225	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10224		"[{""reference_id"": ""RHEA:10224"", ""source_assertion"": ""Rhea associates EC:2.7.1.35 with the reaction family containing RHEA:10225."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:10224"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxal kinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/10224""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-027_94e103770f73	EC:2.7.1.35	pathwaymech:catalyzes	RHEA:25105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25104		"[{""reference_id"": ""RHEA:25104"", ""source_assertion"": ""Rhea associates EC:2.7.1.35 with the reaction family containing RHEA:25105."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:25104"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxamine kinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/25104""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-028_297df81f3e9a	EC:1.4.3.5	pathwaymech:catalyzes	RHEA:15818	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15817		"[{""reference_id"": ""RHEA:15817"", ""source_assertion"": ""Rhea associates EC:1.4.3.5 with the reaction family containing RHEA:15818."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:15817"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxamine 5'-phosphate oxidase reaction"", ""url"": ""https://www.rhea-db.org/rhea/15817""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-029_b9b1cd72b368	EC:2.7.1.35	pathwaymech:catalyzes	RHEA:25109	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25108		"[{""reference_id"": ""RHEA:25108"", ""source_assertion"": ""Rhea associates EC:2.7.1.35 with the reaction family containing RHEA:25109."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:25108"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxine kinase reaction"", ""url"": ""https://www.rhea-db.org/rhea/25108""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-030_67842fb53c88	EC:1.4.3.5	pathwaymech:catalyzes	RHEA:15150	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15149		"[{""reference_id"": ""RHEA:15149"", ""source_assertion"": ""Rhea associates EC:1.4.3.5 with the reaction family containing RHEA:15150."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:15149"", ""source_version"": ""139"", ""title"": ""Rhea pyridoxine 5'-phosphate oxidase reaction"", ""url"": ""https://www.rhea-db.org/rhea/15149""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-031_d8b6db72d492	RHEA:25105	pathwaymech:precedes	RHEA:15818	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PLPSAL-PWY		"[{""reference_id"": ""MetaCyc:PLPSAL-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:25105 before RHEA:15818 in this pathway. Shared intermediate: CHEBI:58451."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PLPSAL-PWY"", ""source_sha256"": ""49f838af2a3f143075cb2e195b184cd75f0e9c09dffe4a37f51c63674a82df09"", ""source_version"": ""22.5"", ""title"": ""MetaCyc pyridoxal 5'-phosphate salvage I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PLPSAL-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-032_498635fe4078	RHEA:25109	pathwaymech:precedes	RHEA:15150	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PLPSAL-PWY		"[{""reference_id"": ""MetaCyc:PLPSAL-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:25109 before RHEA:15150 in this pathway. Shared intermediate: CHEBI:58589."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PLPSAL-PWY"", ""source_sha256"": ""49f838af2a3f143075cb2e195b184cd75f0e9c09dffe4a37f51c63674a82df09"", ""source_version"": ""22.5"", ""title"": ""MetaCyc pyridoxal 5'-phosphate salvage I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PLPSAL-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-033_b67251991111	UniProtKB:P0AFI7	pathwaymech:enables	RHEA:15818	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AFI7		"[{""reference_id"": ""UniProtKB:P0AFI7"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AFI7 with catalytic activity for the reaction family of RHEA:15818. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AFI7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AFI7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AFI7.json""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-034_d462a6e8a2c5	UniProtKB:P0AFI7	pathwaymech:enables	RHEA:15150	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AFI7		"[{""reference_id"": ""UniProtKB:P0AFI7"", ""source_assertion"": ""UniProt annotates UniProtKB:P0AFI7 with catalytic activity for the reaction family of RHEA:15150. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0AFI7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AFI7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AFI7.json""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-035_0a8756b7a57c	UniProtKB:P0AFI7	pathwaymech:has_cofactor	CHEBI:58210	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AFI7		"[{""reference_id"": ""UniProtKB:P0AFI7"", ""source_assertion"": ""UniProt lists CHEBI:58210 as a cofactor of UniProtKB:P0AFI7 (evidence: ECO:0000269). Binds 1 FMN per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0AFI7"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0AFI7 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AFI7.json""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-036_9753a06b111c	UniProtKB:P40191	pathwaymech:enables	RHEA:10225	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40191		"[{""reference_id"": ""UniProtKB:P40191"", ""source_assertion"": ""UniProt annotates UniProtKB:P40191 with catalytic activity for the reaction family of RHEA:10225. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P40191"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P40191 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P40191.json""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-037_79ee98bde94a	UniProtKB:P40191	pathwaymech:enables	RHEA:25109	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40191		"[{""reference_id"": ""UniProtKB:P40191"", ""source_assertion"": ""UniProt annotates UniProtKB:P40191 with catalytic activity for the reaction family of RHEA:25109. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P40191"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P40191 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P40191.json""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-038_5a0f610f5ddd	UniProtKB:P40191	pathwaymech:enables	RHEA:25105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40191		"[{""reference_id"": ""UniProtKB:P40191"", ""source_assertion"": ""UniProt annotates UniProtKB:P40191 with catalytic activity for the reaction family of RHEA:25105. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P40191"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P40191 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P40191.json""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-039_07f953ac0e57	UniProtKB:P40191	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40191		"[{""reference_id"": ""UniProtKB:P40191"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P40191 (evidence: ECO:0000269). Can use both zinc and magnesium that is complexed with ATP. However, magnesium seems to be the preferred metal used under physiological conditions."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P40191"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P40191 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P40191.json""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-040_7d0adf10d7cd	UniProtKB:P40191	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40191		"[{""reference_id"": ""UniProtKB:P40191"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P40191 (evidence: ECO:0000269). Can use both zinc and magnesium that is complexed with ATP. However, magnesium seems to be the preferred metal used under physiological conditions."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P40191"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P40191 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P40191.json""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-041_89601a9e12a7	UniProtKB:P77150	pathwaymech:enables	RHEA:10225	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77150		"[{""reference_id"": ""UniProtKB:P77150"", ""source_assertion"": ""UniProt annotates UniProtKB:P77150 with catalytic activity for the reaction family of RHEA:10225. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P77150"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P77150 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77150.json""}]"	""
pathwaymech:MetaCyc_PLPSAL-PWY_edge-042_e57a03fb2dbf	UniProtKB:P77150	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77150		"[{""reference_id"": ""UniProtKB:P77150"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P77150 (evidence: ECO:0000255). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P77150"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P77150 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77150.json""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-001_b41d04148278	CHEBI:15698	pathwaymech:consumes	RHEA:13434	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13434		"[{""reference_id"": ""RHEA:13434"", ""source_assertion"": ""Rhea RHEA:13434 assigns CHEBI:15698 to substrates with coefficient 1; the compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13434']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13433_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13433_compound_5580']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:13434"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 13434"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-002_b79d5ce3b7ca	CHEBI:15377	pathwaymech:consumes	RHEA:13434	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13434		"[{""reference_id"": ""RHEA:13434"", ""source_assertion"": ""Rhea RHEA:13434 assigns CHEBI:15377 to substrates with coefficient 1; the compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13434']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13433_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13433_compound_1283']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:13434"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 13434"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-003_b14a3d1c171b	CHEBI:15378	pathwaymech:consumes	RHEA:13434	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13434		"[{""reference_id"": ""RHEA:13434"", ""source_assertion"": ""Rhea RHEA:13434 assigns CHEBI:15378 to substrates with coefficient 1; the compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13434']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13433_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13433_compound_3249']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:13434"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 13434"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-004_d12733449415	RHEA:13434	pathwaymech:produces	CHEBI:16450	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13434		"[{""reference_id"": ""RHEA:13434"", ""source_assertion"": ""Rhea RHEA:13434 assigns CHEBI:16450 to products with coefficient 1; the compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13434']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13433_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13433_compound_5154']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:13434"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 13434"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-005_20102aeecfb7	RHEA:13434	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13434		"[{""reference_id"": ""RHEA:13434"", ""source_assertion"": ""Rhea RHEA:13434 assigns CHEBI:28938 to products with coefficient 1; the compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13434']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13433_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13433_compound_1012']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:13434"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 13434"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-006_4ed95049a59a	CHEBI:16450	pathwaymech:consumes	RHEA:22825	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22825		"[{""reference_id"": ""RHEA:22825"", ""source_assertion"": ""Rhea RHEA:22825 assigns CHEBI:16450 to substrates with coefficient 1; the compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22825']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/22824_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_22824_compound_5154']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:22825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 22825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-007_e38bdfad1e3d	CHEBI:43474	pathwaymech:consumes	RHEA:22825	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22825		"[{""reference_id"": ""RHEA:22825"", ""source_assertion"": ""Rhea RHEA:22825 assigns CHEBI:43474 to substrates with coefficient 1; the compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22825']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/22824_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_22824_compound_5518']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:22825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 22825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-008_a12ef11521a2	RHEA:22825	pathwaymech:produces	CHEBI:57259	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22825		"[{""reference_id"": ""RHEA:22825"", ""source_assertion"": ""Rhea RHEA:22825 assigns CHEBI:57259 to products with coefficient 1; the compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22825']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/22824_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_22824_compound_3098']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:22825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 22825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-009_c01ff9e07b57	RHEA:22825	pathwaymech:produces	CHEBI:17568	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22825		"[{""reference_id"": ""RHEA:22825"", ""source_assertion"": ""Rhea RHEA:22825 assigns CHEBI:17568 to products with coefficient 1; the compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22825']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/22824_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_22824_compound_4063']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:22825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 22825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-010_431c743922c7	CHEBI:17748	pathwaymech:consumes	RHEA:16038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16038		"[{""reference_id"": ""RHEA:16038"", ""source_assertion"": ""Rhea RHEA:16038 assigns CHEBI:17748 to substrates with coefficient 1; the compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16038']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16037_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16037_compound_4636']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:16038"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 16038"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-011_2618065df8d8	CHEBI:43474	pathwaymech:consumes	RHEA:16038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16038		"[{""reference_id"": ""RHEA:16038"", ""source_assertion"": ""Rhea RHEA:16038 assigns CHEBI:43474 to substrates with coefficient 1; the compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16038']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16037_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16037_compound_5518']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:16038"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 16038"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-012_d8dd7290a429	RHEA:16038	pathwaymech:produces	CHEBI:57259	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16038		"[{""reference_id"": ""RHEA:16038"", ""source_assertion"": ""Rhea RHEA:16038 assigns CHEBI:57259 to products with coefficient 1; the compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16038']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16037_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16037_compound_3098']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:16038"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 16038"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-013_235818068155	RHEA:16038	pathwaymech:produces	CHEBI:17821	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16038		"[{""reference_id"": ""RHEA:16038"", ""source_assertion"": ""Rhea RHEA:16038 assigns CHEBI:17821 to products with coefficient 1; the compound resolves to this exact ChEBI species."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16038']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16037_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16037_compound_2794']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:16038"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 16038"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-014_d1ca4c0e01f1	UniProtKB:P0ABF6	BFO:0000050	MetaCyc:CYTIDEAM-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CYTIDEAM-CPLX|MetaCyc:CYTIDEAM-MONOMER|PMID:8289286	Homodimer membership; the protein component is not represented as an independently active monomer.	"[{""reference_id"": ""MetaCyc:CYTIDEAM-CPLX"", ""source_assertion"": ""The native complex contains two copies of CYTIDEAM-MONOMER."", ""source_locator"": ""Protein[@frameid='CYTIDEAM-CPLX']/component/Protein; component/coefficient""}, {""reference_id"": ""MetaCyc:CYTIDEAM-MONOMER"", ""source_assertion"": ""The component has an explicit UNIPROT unification cross-reference to P0ABF6."", ""source_locator"": ""Protein[@frameid='CYTIDEAM-MONOMER']/dblink[dblink-db='UNIPROT'][dblink-relationship='unification']/dblink-oid""}, {""reference_id"": ""PMID:8289286"", ""source_assertion"": ""The primary abstract describes the E. coli cytidine deaminase alpha2 dimer and active sites formed across its subunit interface."", ""source_locator"": ""Primary abstract; full publisher article was not available locally.""}]"	"[{""id"": ""MetaCyc:CYTIDEAM-CPLX"", ""source_sha256"": ""a83540fb3c9887be2fb004b2e00f43bc920bf5c6e811704143f9d4025d8f879d"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native CYTIDEAM-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYTIDEAM-CPLX""}, {""id"": ""MetaCyc:CYTIDEAM-MONOMER"", ""source_sha256"": ""135aeade3641f73a1b1d7f4330f4f127facc3822af12e1a5dbc509db9f6836f6"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native CYTIDEAM-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYTIDEAM-MONOMER""}, {""id"": ""PMID:8289286"", ""source_sha256"": ""7070f1230543d24d3d26a7e26f40d157a88b1696f3d1e2271fadb6b823883b8e"", ""source_version"": ""Primary abstract inspected; no full-text claim"", ""title"": ""Cytidine deaminase. The 2.3 A crystal structure of an enzyme: transition-state analog complex."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8289286%20AND%20SRC:MED&format=json&resultType=core""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-015_1512b06ed86a	UniProtKB:P07650	BFO:0000050	MetaCyc:DEOA-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOA-CPLX|MetaCyc:DEOA-MONOMER|PMID:2199449	Homodimer membership; the protein component is not represented as an independently active monomer.	"[{""reference_id"": ""MetaCyc:DEOA-CPLX"", ""source_assertion"": ""The native complex contains two copies of DEOA-MONOMER."", ""source_locator"": ""Protein[@frameid='DEOA-CPLX']/component/Protein; component/coefficient""}, {""reference_id"": ""MetaCyc:DEOA-MONOMER"", ""source_assertion"": ""The component has an explicit UNIPROT unification cross-reference to P07650."", ""source_locator"": ""Protein[@frameid='DEOA-MONOMER']/dblink[dblink-db='UNIPROT'][dblink-relationship='unification']/dblink-oid""}, {""reference_id"": ""PMID:2199449"", ""source_assertion"": ""The primary abstract reports an E. coli thymidine phosphorylase crystal dimer and the deoA-derived amino-acid sequence."", ""source_locator"": ""Primary abstract; full publisher article was not available locally.""}]"	"[{""id"": ""MetaCyc:DEOA-CPLX"", ""source_sha256"": ""1b414dc3564b266b9e990fd5ae7486e6dbb8cca4e857045320da94e2627028c2"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOA-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOA-CPLX""}, {""id"": ""MetaCyc:DEOA-MONOMER"", ""source_sha256"": ""cfcac422af04caa24451e2d09f17ff6c91399bc3344a4061de5c160633277d75"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOA-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOA-MONOMER""}, {""id"": ""PMID:2199449"", ""source_sha256"": ""1bed3f0ec9b3f64ba5e9b1fcc5a543aeaffcca7cc476c31f8f090388a5f1050d"", ""source_version"": ""Primary abstract inspected; no full-text claim"", ""title"": ""Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:2199449%20AND%20SRC:MED&format=json&resultType=core""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-016_f0fde50fa0b6	MetaCyc:CYTIDEAM-CPLX	pathwaymech:catalyzes	RHEA:13434	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CYTIDEAM-RXN|PMID:17827303|PMID:4202859	Direct biochemical support is from a constitutive E. coli mutant, and genetic support is from K-12 mutant derivatives; the native complex annotation supplies MG1655 scope.	"[{""reference_id"": ""MetaCyc:CYTIDEAM-RXN"", ""source_assertion"": ""CYTIDEAM-ENZRXN assigns CYTIDEAM-CPLX to deoxycytidine deamination and the reaction has an exact RHEA:13434 unification link."", ""source_locator"": ""Reaction[@frameid='CYTIDEAM-RXN']/enzymatic-reaction/Enzymatic-Reaction[@frameid='CYTIDEAM-ENZRXN']/enzyme; dblink[dblink-db='RHEA']""}, {""reference_id"": ""PMID:4202859"", ""source_assertion"": ""Partially purified enzyme from E. coli Y-70-272 deaminates deoxycytidine; the assay identifies deoxyuridine and substrate-specificity measurements include deoxycytidine."", ""source_locator"": ""Materials and Methods, pp.797-798; Results, Substrate Specificity and Table VI, p.802.""}, {""reference_id"": ""PMID:17827303"", ""source_assertion"": ""In a K-12 dcd deoA background, cdd mutation strongly increased thymidine dependence; this supports the deoxycytidine-to-deoxyuridine step in that mutant context."", ""source_locator"": ""Results, From dCMP to dCyd; Figure 3; Table 1 footnote a.""}]"	"[{""id"": ""MetaCyc:CYTIDEAM-RXN"", ""source_sha256"": ""7897d52befade144490b11bcb4a988ef0ae6c399aaac366cb0df8ba47906e425"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native CYTIDEAM-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYTIDEAM-RXN""}, {""id"": ""PMID:17827303"", ""source_sha256"": ""0638bb23989b09ca9057114d65e818c8848547e268d2181a69eea7efa68d424f"", ""source_version"": ""2007 primary full text"", ""title"": ""The Deoxycytidine Pathway for Thymidylate Synthesis in Escherichia coli"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2168750/""}, {""id"": ""PMID:4202859"", ""source_sha256"": ""d094077fc2c51687a68d397866a9bc3f54aff1c42ea120a602b9b1dcb0f7aed4"", ""source_version"": ""1973 primary full text, pp.797-803"", ""title"": ""The purification and properties of cytidine deaminase from Escherichia coli."", ""url"": ""https://www.jstage.jst.go.jp/article/biochemistry1922/74/4/74_4_797/_pdf""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-017_d9073e3a6757	MetaCyc:DEOA-CPLX	pathwaymech:catalyzes	RHEA:22825	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:URA-PHOSPH-RXN|PMID:8157589|RHEA:22825	Degradation direction selected from a reversible phosphorolysis. This is the native DeoA complex, not a separate Udp enzyme.	"[{""reference_id"": ""MetaCyc:URA-PHOSPH-RXN"", ""source_assertion"": ""The native URA-PHOSPH-RXN enzymatic-reaction assigns DEOA-CPLX to deoxyuridine phosphorolysis, and its Rhea unification link is the reversible family member 22827."", ""source_locator"": ""Reaction[@frameid='URA-PHOSPH-RXN']/enzymatic-reaction; reaction-direction; dblink[dblink-db='RHEA']""}, {""reference_id"": ""RHEA:22825"", ""source_assertion"": ""Rhea master 22824 has bidirectionalReaction 22827 and directionalReaction 22825; 22825 is the left-to-right degradation equation."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22824']/rh:bidirectionalReaction; rh:directionalReaction; rdf:Description[@rdf:about='http://rdf.rhea-db.org/22825']/rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""PMID:8157589"", ""source_assertion"": ""The primary abstract reports that a deoA mutation spares deoxyuridine from catabolism in E. coli dcd mutants; the work does not quantify this flux in wild-type cells."", ""source_locator"": ""Primary abstract, results and final scope statement.""}]"	"[{""id"": ""MetaCyc:URA-PHOSPH-RXN"", ""source_sha256"": ""f30864c9da2d9dbef16400db8f9faa248955cdb76bb11267e98a982400215ff8"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native URA-PHOSPH-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:URA-PHOSPH-RXN""}, {""id"": ""PMID:8157589"", ""source_sha256"": ""814e42ec6f6abb9199d43428efe36f8441e582d121904abd027a230c831a9c49"", ""source_version"": ""Primary abstract inspected; full-text acquisition unavailable"", ""title"": ""De novo synthesis of thymidylate via deoxycytidine in dcd mutants of Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8157589%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""RHEA:22825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 22825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-018_33acaa999154	MetaCyc:DEOA-CPLX	pathwaymech:catalyzes	RHEA:16038	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:THYM-PHOSPH-RXN|RHEA:16038|UniProtKB:P07650	Degradation direction selected from a reversible phosphorolysis. This is the native DeoA complex, not a separate Udp enzyme.	"[{""reference_id"": ""MetaCyc:THYM-PHOSPH-RXN"", ""source_assertion"": ""The native THYM-PHOSPH-RXN enzymatic-reaction assigns DEOA-CPLX to thymidine phosphorolysis, and its Rhea unification link is the reversible family member 16040."", ""source_locator"": ""Reaction[@frameid='THYM-PHOSPH-RXN']/enzymatic-reaction; reaction-direction; dblink[dblink-db='RHEA']""}, {""reference_id"": ""RHEA:16038"", ""source_assertion"": ""Rhea master 16037 has bidirectionalReaction 16040 and directionalReaction 16038; 16038 is the left-to-right degradation equation."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16037']/rh:bidirectionalReaction; rh:directionalReaction; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16038']/rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""UniProtKB:P07650"", ""source_assertion"": ""Reviewed P07650 catalytic activity names thymidine plus phosphate yielding sugar phosphate and thymine, with RHEA:16037; the function describes reversible phosphorolysis."", ""source_locator"": ""/comments/0 (FUNCTION); /comments/1/reaction (CATALYTIC ACTIVITY).""}]"	"[{""id"": ""MetaCyc:THYM-PHOSPH-RXN"", ""source_sha256"": ""204139aae73f875ab995c9c129397b011527eafe9d26aeb542e2d584809be854"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native THYM-PHOSPH-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:THYM-PHOSPH-RXN""}, {""id"": ""RHEA:16038"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 16038"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P07650"", ""source_sha256"": ""6457feb8ab1f827190467c8c6bc37cc1a397f101f6dbda9e7ae0e2aa81bc1c1c"", ""source_version"": ""UniProt release 2026_03; response header dated 02-September-2026"", ""title"": ""Reviewed UniProtKB P07650"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07650.json""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-019_6fdc4c58ed2a	UniProtKB:P0ABF6	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:8289286|UniProtKB:P0ABF6	Bound catalytic zinc is distinguished from inhibition by added free zinc in the 1973 assay. No zinc-consumption reaction is asserted.	"[{""reference_id"": ""UniProtKB:P0ABF6"", ""source_assertion"": ""Reviewed P0ABF6 explicitly annotates Zn(2+) CHEBI:29105 as cofactor, supported by three experimental structural publications; the note states one zinc ion."", ""source_locator"": ""/comments/3/cofactors/0; /comments/3/note.""}, {""reference_id"": ""PMID:8289286"", ""source_assertion"": ""The E. coli cytidine deaminase structural abstract places zinc in the active-site pocket formed by the dimer."", ""source_locator"": ""Primary abstract, zinc-binding pocket and coordination description.""}]"	"[{""id"": ""PMID:8289286"", ""source_sha256"": ""7070f1230543d24d3d26a7e26f40d157a88b1696f3d1e2271fadb6b823883b8e"", ""source_version"": ""Primary abstract inspected; no full-text claim"", ""title"": ""Cytidine deaminase. The 2.3 A crystal structure of an enzyme: transition-state analog complex."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8289286%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P0ABF6"", ""source_sha256"": ""ecffd6fea9810f3756dfa4dd7c17be85954ab1f19b73ad98660394b2c20a0637"", ""source_version"": ""UniProt release 2026_03; response header dated 02-September-2026"", ""title"": ""Reviewed UniProtKB P0ABF6"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABF6.json""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-020_51d26abb4034	UniProtKB:P0ABF6	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CYTIDEAM-MONOMER	Native MG1655 component-location annotation; not inferred from osmotic-shock recovery in a different strain.	"[{""reference_id"": ""MetaCyc:CYTIDEAM-MONOMER"", ""source_assertion"": ""The native component CYTIDEAM-MONOMER, unified with UniProtKB:P0ABF6, is explicitly located in CCO-CYTOSOL."", ""source_locator"": ""Protein[@frameid='CYTIDEAM-MONOMER']/location/cco[@frameid='CCO-CYTOSOL']; dblink[dblink-db='UNIPROT']""}]"	"[{""id"": ""MetaCyc:CYTIDEAM-MONOMER"", ""source_sha256"": ""135aeade3641f73a1b1d7f4330f4f127facc3822af12e1a5dbc509db9f6836f6"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native CYTIDEAM-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYTIDEAM-MONOMER""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-021_b12fb418537a	UniProtKB:P07650	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOA-MONOMER	Native MG1655 component-location annotation; not inferred from osmotic-shock recovery in a different strain.	"[{""reference_id"": ""MetaCyc:DEOA-MONOMER"", ""source_assertion"": ""The native component DEOA-MONOMER, unified with UniProtKB:P07650, is explicitly located in CCO-CYTOSOL."", ""source_locator"": ""Protein[@frameid='DEOA-MONOMER']/location/cco[@frameid='CCO-CYTOSOL']; dblink[dblink-db='UNIPROT']""}]"	"[{""id"": ""MetaCyc:DEOA-MONOMER"", ""source_sha256"": ""cfcac422af04caa24451e2d09f17ff6c91399bc3344a4061de5c160633277d75"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOA-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOA-MONOMER""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-022_ec8b702a1199	RHEA:13434	BFO:0000050	MetaCyc:PWY-7181	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CYTIDEAM-RXN|MetaCyc:PWY-7181|RHEA:13434		"[{""reference_id"": ""MetaCyc:PWY-7181"", ""source_assertion"": ""The complete native reaction-list includes CYTIDEAM-RXN; its reaction-layout selects L2R toward degradation products."", ""source_locator"": ""Pathway[@frameid='PWY-7181']/reaction-list/Reaction[@frameid='CYTIDEAM-RXN']; reaction-layout[Reaction/@frameid='CYTIDEAM-RXN']/direction""}, {""reference_id"": ""MetaCyc:CYTIDEAM-RXN"", ""source_assertion"": ""The native reaction explicitly links PWY-7181 and its exact Rhea family; independent Rhea triples select RHEA:13434."", ""source_locator"": ""Reaction[@frameid='CYTIDEAM-RXN']/in-pathway; dblink[dblink-db='RHEA']""}, {""reference_id"": ""RHEA:13434"", ""source_assertion"": ""Rhea family 13433 explicitly assigns 13434 as the left-to-right directional member."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13433']/rh:directionalReaction; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13434']/rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""MetaCyc:CYTIDEAM-RXN"", ""source_sha256"": ""7897d52befade144490b11bcb4a988ef0ae6c399aaac366cb0df8ba47906e425"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native CYTIDEAM-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYTIDEAM-RXN""}, {""id"": ""MetaCyc:PWY-7181"", ""source_sha256"": ""358a78be26db295045230b3dfead93293a203f836e88d67f7d28d055b58ead62"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc pyrimidine deoxyribonucleosides degradation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7181""}, {""id"": ""RHEA:13434"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 13434"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-023_68cbf2bf42e8	RHEA:22825	BFO:0000050	MetaCyc:PWY-7181	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7181|MetaCyc:URA-PHOSPH-RXN|RHEA:22825		"[{""reference_id"": ""MetaCyc:PWY-7181"", ""source_assertion"": ""The complete native reaction-list includes URA-PHOSPH-RXN; its reaction-layout selects L2R toward degradation products."", ""source_locator"": ""Pathway[@frameid='PWY-7181']/reaction-list/Reaction[@frameid='URA-PHOSPH-RXN']; reaction-layout[Reaction/@frameid='URA-PHOSPH-RXN']/direction""}, {""reference_id"": ""MetaCyc:URA-PHOSPH-RXN"", ""source_assertion"": ""The native reaction explicitly links PWY-7181 and its exact Rhea family; independent Rhea triples select RHEA:22825."", ""source_locator"": ""Reaction[@frameid='URA-PHOSPH-RXN']/in-pathway; dblink[dblink-db='RHEA']""}, {""reference_id"": ""RHEA:22825"", ""source_assertion"": ""Rhea family 22824 explicitly assigns 22825 as the left-to-right directional member."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22824']/rh:directionalReaction; rdf:Description[@rdf:about='http://rdf.rhea-db.org/22825']/rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""MetaCyc:PWY-7181"", ""source_sha256"": ""358a78be26db295045230b3dfead93293a203f836e88d67f7d28d055b58ead62"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc pyrimidine deoxyribonucleosides degradation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7181""}, {""id"": ""MetaCyc:URA-PHOSPH-RXN"", ""source_sha256"": ""f30864c9da2d9dbef16400db8f9faa248955cdb76bb11267e98a982400215ff8"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native URA-PHOSPH-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:URA-PHOSPH-RXN""}, {""id"": ""RHEA:22825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 22825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-024_754091997f3a	RHEA:16038	BFO:0000050	MetaCyc:PWY-7181	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7181|MetaCyc:THYM-PHOSPH-RXN|RHEA:16038		"[{""reference_id"": ""MetaCyc:PWY-7181"", ""source_assertion"": ""The complete native reaction-list includes THYM-PHOSPH-RXN; its reaction-layout selects L2R toward degradation products."", ""source_locator"": ""Pathway[@frameid='PWY-7181']/reaction-list/Reaction[@frameid='THYM-PHOSPH-RXN']; reaction-layout[Reaction/@frameid='THYM-PHOSPH-RXN']/direction""}, {""reference_id"": ""MetaCyc:THYM-PHOSPH-RXN"", ""source_assertion"": ""The native reaction explicitly links PWY-7181 and its exact Rhea family; independent Rhea triples select RHEA:16038."", ""source_locator"": ""Reaction[@frameid='THYM-PHOSPH-RXN']/in-pathway; dblink[dblink-db='RHEA']""}, {""reference_id"": ""RHEA:16038"", ""source_assertion"": ""Rhea family 16037 explicitly assigns 16038 as the left-to-right directional member."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16037']/rh:directionalReaction; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16038']/rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""MetaCyc:PWY-7181"", ""source_sha256"": ""358a78be26db295045230b3dfead93293a203f836e88d67f7d28d055b58ead62"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc pyrimidine deoxyribonucleosides degradation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7181""}, {""id"": ""MetaCyc:THYM-PHOSPH-RXN"", ""source_sha256"": ""204139aae73f875ab995c9c129397b011527eafe9d26aeb542e2d584809be854"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native THYM-PHOSPH-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:THYM-PHOSPH-RXN""}, {""id"": ""RHEA:16038"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 16038"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7181_pyrimidine-edge-025_d455e6e7edf6	RHEA:13434	RO:0002413	RHEA:22825	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7181|RHEA:13434|RHEA:22825	Shared-intermediate flow only. The separate thymidine branch is not chained to deoxyuridine phosphorolysis merely because the native layout also lists it as a predecessor.	"[{""reference_id"": ""MetaCyc:PWY-7181"", ""source_assertion"": ""URA-PHOSPH-RXN has CYTIDEAM-RXN as a predecessor; their selected layouts produce and consume DEOXYURIDINE, respectively."", ""source_locator"": ""Pathway[@frameid='PWY-7181']/reaction-ordering[Reaction/@frameid='URA-PHOSPH-RXN']/predecessor-reactions/Reaction[@frameid='CYTIDEAM-RXN']; reaction-layout""}, {""reference_id"": ""RHEA:13434"", ""source_assertion"": ""The selected deamination produces CHEBI:16450, the exact deoxyuridine species consumed by RHEA:22825."", ""source_locator"": ""rh:products => 13433_R; Participant_13433_compound_5154/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:22825"", ""source_assertion"": ""The selected phosphorolysis consumes CHEBI:16450, the output of RHEA:13434."", ""source_locator"": ""rh:substrates => 22824_L; Participant_22824_compound_5154/rh:compound/rh:chebi""}]"	"[{""id"": ""MetaCyc:PWY-7181"", ""source_sha256"": ""358a78be26db295045230b3dfead93293a203f836e88d67f7d28d055b58ead62"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc pyrimidine deoxyribonucleosides degradation"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7181""}, {""id"": ""RHEA:13434"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 13434"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:22825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 22825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-001_01c86fd3ead1	CHEBI:15698	pathwaymech:consumes	RHEA:13434	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13434		"[{""reference_id"": ""RHEA:13434"", ""source_assertion"": ""Rhea 13434 assigns CHEBI:15698 to substrates with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13434']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13433_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13433_compound_5580']; http://rdf.rhea-db.org/Participant_13433_compound_5580/rh:compound; http://rdf.rhea-db.org/Compound_5580/rh:chebi""}]"	"[{""id"": ""RHEA:13434"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 13434"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-002_cf0846123746	CHEBI:15377	pathwaymech:consumes	RHEA:13434	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13434		"[{""reference_id"": ""RHEA:13434"", ""source_assertion"": ""Rhea 13434 assigns CHEBI:15377 to substrates with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13434']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13433_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13433_compound_1283']; http://rdf.rhea-db.org/Participant_13433_compound_1283/rh:compound; http://rdf.rhea-db.org/Compound_1283/rh:chebi""}]"	"[{""id"": ""RHEA:13434"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 13434"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-003_0f71790bde58	CHEBI:15378	pathwaymech:consumes	RHEA:13434	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13434		"[{""reference_id"": ""RHEA:13434"", ""source_assertion"": ""Rhea 13434 assigns CHEBI:15378 to substrates with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13434']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13433_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13433_compound_3249']; http://rdf.rhea-db.org/Participant_13433_compound_3249/rh:compound; http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:13434"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 13434"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-004_2da15c3bd093	RHEA:13434	pathwaymech:produces	CHEBI:16450	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13434		"[{""reference_id"": ""RHEA:13434"", ""source_assertion"": ""Rhea 13434 assigns CHEBI:16450 to products with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13434']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13433_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13433_compound_5154']; http://rdf.rhea-db.org/Participant_13433_compound_5154/rh:compound; http://rdf.rhea-db.org/Compound_5154/rh:chebi""}]"	"[{""id"": ""RHEA:13434"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 13434"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-005_e182fdd45515	RHEA:13434	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13434		"[{""reference_id"": ""RHEA:13434"", ""source_assertion"": ""Rhea 13434 assigns CHEBI:28938 to products with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13434']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13433_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13433_compound_1012']; http://rdf.rhea-db.org/Participant_13433_compound_1012/rh:compound; http://rdf.rhea-db.org/Compound_1012/rh:chebi""}]"	"[{""id"": ""RHEA:13434"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 13434"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-006_37404bbf3282	CHEBI:16450	pathwaymech:consumes	RHEA:22825	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22825		"[{""reference_id"": ""RHEA:22825"", ""source_assertion"": ""Rhea 22825 assigns CHEBI:16450 to substrates with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22825']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/22824_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_22824_compound_5154']; http://rdf.rhea-db.org/Participant_22824_compound_5154/rh:compound; http://rdf.rhea-db.org/Compound_5154/rh:chebi""}]"	"[{""id"": ""RHEA:22825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 22825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-007_3b3f302594f2	CHEBI:43474	pathwaymech:consumes	RHEA:22825	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22825		"[{""reference_id"": ""RHEA:22825"", ""source_assertion"": ""Rhea 22825 assigns CHEBI:43474 to substrates with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22825']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/22824_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_22824_compound_5518']; http://rdf.rhea-db.org/Participant_22824_compound_5518/rh:compound; http://rdf.rhea-db.org/Compound_5518/rh:chebi""}]"	"[{""id"": ""RHEA:22825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 22825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-008_d0350b75f1d1	RHEA:22825	pathwaymech:produces	CHEBI:57259	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22825		"[{""reference_id"": ""RHEA:22825"", ""source_assertion"": ""Rhea 22825 assigns CHEBI:57259 to products with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22825']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/22824_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_22824_compound_3098']; http://rdf.rhea-db.org/Participant_22824_compound_3098/rh:compound; http://rdf.rhea-db.org/Compound_3098/rh:chebi""}]"	"[{""id"": ""RHEA:22825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 22825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-009_931415654a67	RHEA:22825	pathwaymech:produces	CHEBI:17568	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22825		"[{""reference_id"": ""RHEA:22825"", ""source_assertion"": ""Rhea 22825 assigns CHEBI:17568 to products with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22825']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/22824_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_22824_compound_4063']; http://rdf.rhea-db.org/Participant_22824_compound_4063/rh:compound; http://rdf.rhea-db.org/Compound_4063/rh:chebi""}]"	"[{""id"": ""RHEA:22825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 22825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-010_90161ca04d00	CHEBI:57259	pathwaymech:consumes	RHEA:16039	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16039		"[{""reference_id"": ""RHEA:16039"", ""source_assertion"": ""Rhea 16039 assigns CHEBI:57259 to substrates with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16039']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16037_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16037_compound_3098']; http://rdf.rhea-db.org/Participant_16037_compound_3098/rh:compound; http://rdf.rhea-db.org/Compound_3098/rh:chebi""}]"	"[{""id"": ""RHEA:16039"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 16039"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-011_4fcdabfba363	CHEBI:17821	pathwaymech:consumes	RHEA:16039	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16039		"[{""reference_id"": ""RHEA:16039"", ""source_assertion"": ""Rhea 16039 assigns CHEBI:17821 to substrates with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16039']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16037_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16037_compound_2794']; http://rdf.rhea-db.org/Participant_16037_compound_2794/rh:compound; http://rdf.rhea-db.org/Compound_2794/rh:chebi""}]"	"[{""id"": ""RHEA:16039"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 16039"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-012_60543d0d7692	RHEA:16039	pathwaymech:produces	CHEBI:17748	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16039		"[{""reference_id"": ""RHEA:16039"", ""source_assertion"": ""Rhea 16039 assigns CHEBI:17748 to products with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16039']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16037_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16037_compound_4636']; http://rdf.rhea-db.org/Participant_16037_compound_4636/rh:compound; http://rdf.rhea-db.org/Compound_4636/rh:chebi""}]"	"[{""id"": ""RHEA:16039"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 16039"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-013_3794fdd52fec	RHEA:16039	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16039		"[{""reference_id"": ""RHEA:16039"", ""source_assertion"": ""Rhea 16039 assigns CHEBI:43474 to products with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16039']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16037_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16037_compound_5518']; http://rdf.rhea-db.org/Participant_16037_compound_5518/rh:compound; http://rdf.rhea-db.org/Compound_5518/rh:chebi""}]"	"[{""id"": ""RHEA:16039"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 16039"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-014_bb7fd266fd4f	CHEBI:16450	pathwaymech:consumes	RHEA:28207	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28207		"[{""reference_id"": ""RHEA:28207"", ""source_assertion"": ""Rhea 28207 assigns CHEBI:16450 to substrates with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28207']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28206_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28206_compound_5154']; http://rdf.rhea-db.org/Participant_28206_compound_5154/rh:compound; http://rdf.rhea-db.org/Compound_5154/rh:chebi""}]"	"[{""id"": ""RHEA:28207"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 28207"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-015_6d35b72f4166	CHEBI:30616	pathwaymech:consumes	RHEA:28207	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28207		"[{""reference_id"": ""RHEA:28207"", ""source_assertion"": ""Rhea 28207 assigns CHEBI:30616 to substrates with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28207']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28206_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28206_compound_6372']; http://rdf.rhea-db.org/Participant_28206_compound_6372/rh:compound; http://rdf.rhea-db.org/Compound_6372/rh:chebi""}]"	"[{""id"": ""RHEA:28207"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 28207"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-016_96e676ccbfdc	RHEA:28207	pathwaymech:produces	CHEBI:246422	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28207		"[{""reference_id"": ""RHEA:28207"", ""source_assertion"": ""Rhea 28207 assigns CHEBI:246422 to products with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28207']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28206_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28206_compound_4655']; http://rdf.rhea-db.org/Participant_28206_compound_4655/rh:compound; http://rdf.rhea-db.org/Compound_4655/rh:chebi""}]"	"[{""id"": ""RHEA:28207"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 28207"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-017_e7a87823c110	RHEA:28207	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28207		"[{""reference_id"": ""RHEA:28207"", ""source_assertion"": ""Rhea 28207 assigns CHEBI:456216 to products with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28207']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28206_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28206_compound_2710']; http://rdf.rhea-db.org/Participant_28206_compound_2710/rh:compound; http://rdf.rhea-db.org/Compound_2710/rh:chebi""}]"	"[{""id"": ""RHEA:28207"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 28207"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-018_6005517c048c	RHEA:28207	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28207		"[{""reference_id"": ""RHEA:28207"", ""source_assertion"": ""Rhea 28207 assigns CHEBI:15378 to products with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28207']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28206_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28206_compound_3249']; http://rdf.rhea-db.org/Participant_28206_compound_3249/rh:compound; http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:28207"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 28207"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-019_fb7cd8af3448	CHEBI:17748	pathwaymech:consumes	RHEA:19130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19130		"[{""reference_id"": ""RHEA:19130"", ""source_assertion"": ""Rhea 19130 assigns CHEBI:17748 to substrates with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19130']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/19129_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_19129_compound_4636']; http://rdf.rhea-db.org/Participant_19129_compound_4636/rh:compound; http://rdf.rhea-db.org/Compound_4636/rh:chebi""}]"	"[{""id"": ""RHEA:19130"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 19130"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-020_6cccd7153df2	CHEBI:30616	pathwaymech:consumes	RHEA:19130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19130		"[{""reference_id"": ""RHEA:19130"", ""source_assertion"": ""Rhea 19130 assigns CHEBI:30616 to substrates with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19130']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/19129_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_19129_compound_6372']; http://rdf.rhea-db.org/Participant_19129_compound_6372/rh:compound; http://rdf.rhea-db.org/Compound_6372/rh:chebi""}]"	"[{""id"": ""RHEA:19130"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 19130"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-021_348f0afc0c7f	RHEA:19130	pathwaymech:produces	CHEBI:63528	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19130		"[{""reference_id"": ""RHEA:19130"", ""source_assertion"": ""Rhea 19130 assigns CHEBI:63528 to products with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19130']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/19129_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_19129_compound_5064']; http://rdf.rhea-db.org/Participant_19129_compound_5064/rh:compound; http://rdf.rhea-db.org/Compound_5064/rh:chebi""}]"	"[{""id"": ""RHEA:19130"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 19130"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-022_6756e38f35b8	RHEA:19130	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19130		"[{""reference_id"": ""RHEA:19130"", ""source_assertion"": ""Rhea 19130 assigns CHEBI:456216 to products with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19130']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/19129_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_19129_compound_2710']; http://rdf.rhea-db.org/Participant_19129_compound_2710/rh:compound; http://rdf.rhea-db.org/Compound_2710/rh:chebi""}]"	"[{""id"": ""RHEA:19130"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 19130"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-023_54d6fd19344f	RHEA:19130	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19130		"[{""reference_id"": ""RHEA:19130"", ""source_assertion"": ""Rhea 19130 assigns CHEBI:15378 to products with coefficient 1; this is the exact charge and stereochemical species in the native RDF."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19130']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/19129_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_19129_compound_3249']; http://rdf.rhea-db.org/Participant_19129_compound_3249/rh:compound; http://rdf.rhea-db.org/Compound_3249/rh:chebi""}]"	"[{""id"": ""RHEA:19130"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 19130"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-024_c6450eb8073f	UniProtKB:P0ABF6	BFO:0000050	MetaCyc:CYTIDEAM-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CYTIDEAM-CPLX|MetaCyc:CYTIDEAM-MONOMER|PMID:8289286	Homodimer membership; catalysis is assigned to the assembly.	"[{""reference_id"": ""MetaCyc:CYTIDEAM-CPLX"", ""source_assertion"": ""The native complex contains two copies of CYTIDEAM-MONOMER."", ""source_locator"": ""Protein[@frameid='CYTIDEAM-CPLX']/component/Protein; component/coefficient""}, {""reference_id"": ""MetaCyc:CYTIDEAM-MONOMER"", ""source_assertion"": ""The native component has a UNIPROT unification cross-reference to P0ABF6."", ""source_locator"": ""Protein[@frameid='CYTIDEAM-MONOMER']/dblink[dblink-db='UNIPROT'][dblink-relationship='unification']/dblink-oid""}, {""reference_id"": ""PMID:8289286"", ""source_assertion"": ""The primary abstract reports an E. coli cytidine deaminase alpha2 dimer with active sites formed across its subunit interface."", ""source_locator"": ""Europe PMC /resultList/result/0/abstractText; primary abstract only""}]"	"[{""id"": ""MetaCyc:CYTIDEAM-CPLX"", ""source_sha256"": ""b79b75fba322f3718df4000f496c415ee25e3965f9848d13cb1b110437ac5dce"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native CYTIDEAM-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYTIDEAM-CPLX""}, {""id"": ""MetaCyc:CYTIDEAM-MONOMER"", ""source_sha256"": ""135aeade3641f73a1b1d7f4330f4f127facc3822af12e1a5dbc509db9f6836f6"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native CYTIDEAM-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYTIDEAM-MONOMER""}, {""id"": ""PMID:8289286"", ""source_sha256"": ""7070f1230543d24d3d26a7e26f40d157a88b1696f3d1e2271fadb6b823883b8e"", ""source_version"": ""Primary abstract inspected; no full-text claim"", ""title"": ""Cytidine deaminase. The 2.3 A crystal structure of an enzyme: transition-state analog complex."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8289286%20AND%20SRC:MED&format=json&resultType=core""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-025_8e4135254927	UniProtKB:P07650	BFO:0000050	MetaCyc:DEOA-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOA-CPLX|MetaCyc:DEOA-MONOMER|PMID:2199449	Homodimer membership; catalysis is assigned to the assembly.	"[{""reference_id"": ""MetaCyc:DEOA-CPLX"", ""source_assertion"": ""The native complex contains two copies of DEOA-MONOMER."", ""source_locator"": ""Protein[@frameid='DEOA-CPLX']/component/Protein; component/coefficient""}, {""reference_id"": ""MetaCyc:DEOA-MONOMER"", ""source_assertion"": ""The native component has a UNIPROT unification cross-reference to P07650."", ""source_locator"": ""Protein[@frameid='DEOA-MONOMER']/dblink[dblink-db='UNIPROT'][dblink-relationship='unification']/dblink-oid""}, {""reference_id"": ""PMID:2199449"", ""source_assertion"": ""The primary abstract reports an E. coli thymidine phosphorylase crystal dimer and the deoA-derived sequence."", ""source_locator"": ""Europe PMC /resultList/result/0/abstractText; primary abstract only""}]"	"[{""id"": ""MetaCyc:DEOA-CPLX"", ""source_sha256"": ""1b414dc3564b266b9e990fd5ae7486e6dbb8cca4e857045320da94e2627028c2"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOA-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOA-CPLX""}, {""id"": ""MetaCyc:DEOA-MONOMER"", ""source_sha256"": ""fc030ffa47776b04f607f4b26cc1197fd2e2a3223c70c5e759275b251d35bfd6"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOA-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOA-MONOMER""}, {""id"": ""PMID:2199449"", ""source_sha256"": ""1bed3f0ec9b3f64ba5e9b1fcc5a543aeaffcca7cc476c31f8f090388a5f1050d"", ""source_version"": ""Primary abstract inspected; no full-text claim"", ""title"": ""Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:2199449%20AND%20SRC:MED&format=json&resultType=core""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-026_30bbbebe1126	UniProtKB:P23331	BFO:0000050	MetaCyc:CPLX0-8261	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8261|MetaCyc:TDK-MONOMER|PMID:2041474|UniProtKB:P23331	Component membership only. The graph does not fix a tetramer or transfer E. coli B ligand-dependent dimerization to all K-12 conditions.	"[{""reference_id"": ""MetaCyc:CPLX0-8261"", ""source_assertion"": ""The native assembly contains TDK-MONOMER and reports an 82 kDa K-12 enzyme from crude-extract gel filtration; its comment distinguishes ligand-dependent dimerization studies of the E. coli B enzyme."", ""source_locator"": ""Protein[@frameid='CPLX0-8261']/component/Protein; molecular-weight-exp; comment paragraphs 2-3""}, {""reference_id"": ""MetaCyc:TDK-MONOMER"", ""source_assertion"": ""The native component has a UNIPROT unification cross-reference to P23331."", ""source_locator"": ""Protein[@frameid='TDK-MONOMER']/dblink[dblink-db='UNIPROT'][dblink-relationship='unification']/dblink-oid""}, {""reference_id"": ""UniProtKB:P23331"", ""source_assertion"": ""Reviewed UniProt annotates a homotetramer by HAMAP MF_00124 (ECO:0000255); this is an inference rather than a condition-resolved native assembly measurement."", ""source_locator"": ""/comments/3/texts/0/value; /comments/3/texts/0/evidences""}, {""reference_id"": ""PMID:2041474"", ""source_assertion"": ""The primary abstract reports W3110 tdk complementation of TK-deficient KY895 and gel-filtration evidence for a multimeric active enzyme; the abstract does not specify a subunit count."", ""source_locator"": ""Europe PMC /resultList/result/0/abstractText; truncated primary abstract only""}]"	"[{""id"": ""MetaCyc:CPLX0-8261"", ""source_sha256"": ""6a1631bda03bca1deb7fa838d9801e2982c9c1dfd5c4e61e3e98ba6008c2e76d"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native CPLX0-8261"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8261""}, {""id"": ""MetaCyc:TDK-MONOMER"", ""source_sha256"": ""6c0c23e3d8fcb68fcea08f7fc2324c57e256edc037269c920ad5c92e3b515442"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native TDK-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:TDK-MONOMER""}, {""id"": ""PMID:2041474"", ""source_sha256"": ""07076064f64cb10166fcf31bfa5c7ba39e18f3090d88a234772b305b1d915de6"", ""source_version"": ""Primary abstract inspected; no full-text claim"", ""title"": ""Nucleotide sequence of the Escherichia coli thymidine kinase gene provides evidence for conservation of functional domains and quaternary structure."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:2041474%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P23331"", ""source_sha256"": ""a23c1c91bbaf4a3fdffe58d088fd72116f6034a88b252722a14f092841be8043"", ""source_version"": ""UniProt 2026_03; original response release header and entry audit retained"", ""title"": ""Reviewed UniProtKB P23331"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23331.json""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-027_ab3939d0aac8	MetaCyc:CYTIDEAM-CPLX	pathwaymech:catalyzes	RHEA:13434	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CYTIDEAM-CPLX|MetaCyc:CYTIDEAM-RXN|PMID:4202859|RHEA:13434	Native enzyme annotation is distinguished from the strain and access limits of inspected primary evidence.	"[{""reference_id"": ""MetaCyc:CYTIDEAM-CPLX"", ""source_assertion"": ""The native CYTIDEAM-CPLX catalyzes annotation links CYTIDEAM-ENZRXN to CYTIDEAM-RXN."", ""source_locator"": ""Protein[@frameid='CYTIDEAM-CPLX']/catalyzes/Enzymatic-Reaction[@frameid='CYTIDEAM-ENZRXN']/reaction/Reaction[@frameid='CYTIDEAM-RXN']""}, {""reference_id"": ""MetaCyc:CYTIDEAM-RXN"", ""source_assertion"": ""The native reaction has an explicit RHEA:13434 unification cross-reference; its own left/right compounds are retained separately from the selected Rhea direction."", ""source_locator"": ""Reaction[@frameid='CYTIDEAM-RXN']/dblink[dblink-db='RHEA']/dblink-oid; left; right""}, {""reference_id"": ""RHEA:13434"", ""source_assertion"": ""Rhea master 13433 explicitly lists directional member 13434; its substrates, products and equation specify the selected left-to-right transformation."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13433']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/13434']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13434']/rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""PMID:4202859"", ""source_assertion"": ""Partially purified cytidine deaminase from E. coli Y-70-272 deaminates deoxycytidine; this strain-specific enzyme assay supports the activity, not MG1655 wild-type salvage flux."", ""source_locator"": ""Full primary PDF pp.797-798 Materials and Methods/Strains of bacteria and Enzyme assay; p.802 Substrate specificity and Table VI""}]"	"[{""id"": ""MetaCyc:CYTIDEAM-CPLX"", ""source_sha256"": ""b79b75fba322f3718df4000f496c415ee25e3965f9848d13cb1b110437ac5dce"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native CYTIDEAM-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYTIDEAM-CPLX""}, {""id"": ""MetaCyc:CYTIDEAM-RXN"", ""source_sha256"": ""7897d52befade144490b11bcb4a988ef0ae6c399aaac366cb0df8ba47906e425"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native CYTIDEAM-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CYTIDEAM-RXN""}, {""id"": ""PMID:4202859"", ""source_sha256"": ""d094077fc2c51687a68d397866a9bc3f54aff1c42ea120a602b9b1dcb0f7aed4"", ""source_version"": ""1973 primary full text, pp.797-803"", ""title"": ""The purification and properties of cytidine deaminase from Escherichia coli."", ""url"": ""https://www.jstage.jst.go.jp/article/biochemistry1922/74/4/74_4_797/_pdf""}, {""id"": ""RHEA:13434"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 13434"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-028_6def46f44f75	MetaCyc:DEOA-CPLX	pathwaymech:catalyzes	RHEA:22825	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOA-CPLX|MetaCyc:URA-PHOSPH-RXN|RHEA:22825|UniProtKB:P07650	Selected salvage direction; reversible DeoA chemistry does not imply constitutive net flux.	"[{""reference_id"": ""MetaCyc:DEOA-CPLX"", ""source_assertion"": ""The native DEOA-CPLX catalyzes annotation links URA-PHOSPH-ENZRXN to URA-PHOSPH-RXN."", ""source_locator"": ""Protein[@frameid='DEOA-CPLX']/catalyzes/Enzymatic-Reaction[@frameid='URA-PHOSPH-ENZRXN']/reaction/Reaction[@frameid='URA-PHOSPH-RXN']""}, {""reference_id"": ""MetaCyc:URA-PHOSPH-RXN"", ""source_assertion"": ""The native reaction has an explicit RHEA:22827 unification cross-reference; its own left/right compounds are retained separately from the selected Rhea direction."", ""source_locator"": ""Reaction[@frameid='URA-PHOSPH-RXN']/dblink[dblink-db='RHEA']/dblink-oid; left; right""}, {""reference_id"": ""RHEA:22825"", ""source_assertion"": ""Rhea master 22824 explicitly lists directional member 22825; its substrates, products and equation specify the selected left-to-right transformation."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22824']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/22825']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/22825']/rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""UniProtKB:P07650"", ""source_assertion"": ""Reviewed DeoA catalyzes reversible pyrimidine nucleoside phosphorolysis for degradation or rescue of pyrimidine bases; the graph selects deoxyuridine cleavage and thymidine synthesis in this salvage route."", ""source_locator"": ""/comments/0/texts/0/value; /comments/1/reaction; /comments/2/texts""}]"	"[{""id"": ""MetaCyc:DEOA-CPLX"", ""source_sha256"": ""1b414dc3564b266b9e990fd5ae7486e6dbb8cca4e857045320da94e2627028c2"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOA-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOA-CPLX""}, {""id"": ""MetaCyc:URA-PHOSPH-RXN"", ""source_sha256"": ""f30864c9da2d9dbef16400db8f9faa248955cdb76bb11267e98a982400215ff8"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native URA-PHOSPH-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:URA-PHOSPH-RXN""}, {""id"": ""RHEA:22825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 22825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P07650"", ""source_sha256"": ""6457feb8ab1f827190467c8c6bc37cc1a397f101f6dbda9e7ae0e2aa81bc1c1c"", ""source_version"": ""UniProt 2026_03; original response release header and entry audit retained"", ""title"": ""Reviewed UniProtKB P07650"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07650.json""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-029_25e3603e8d70	MetaCyc:DEOA-CPLX	pathwaymech:catalyzes	RHEA:16039	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DEOA-CPLX|MetaCyc:THYM-PHOSPH-RXN|RHEA:16039|UniProtKB:P07650	Selected salvage direction; reversible DeoA chemistry does not imply constitutive net flux.	"[{""reference_id"": ""MetaCyc:DEOA-CPLX"", ""source_assertion"": ""The native DEOA-CPLX catalyzes annotation links THYM-PHOSPH-ENZRXN to THYM-PHOSPH-RXN."", ""source_locator"": ""Protein[@frameid='DEOA-CPLX']/catalyzes/Enzymatic-Reaction[@frameid='THYM-PHOSPH-ENZRXN']/reaction/Reaction[@frameid='THYM-PHOSPH-RXN']""}, {""reference_id"": ""MetaCyc:THYM-PHOSPH-RXN"", ""source_assertion"": ""The native reaction has an explicit RHEA:16040 unification cross-reference; its own left/right compounds are retained separately from the selected Rhea direction."", ""source_locator"": ""Reaction[@frameid='THYM-PHOSPH-RXN']/dblink[dblink-db='RHEA']/dblink-oid; left; right""}, {""reference_id"": ""RHEA:16039"", ""source_assertion"": ""Rhea master 16037 explicitly lists directional member 16039; its substrates, products and equation specify the selected right-to-left transformation."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16037']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/16039']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16039']/rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""UniProtKB:P07650"", ""source_assertion"": ""Reviewed DeoA catalyzes reversible pyrimidine nucleoside phosphorolysis for degradation or rescue of pyrimidine bases; the graph selects deoxyuridine cleavage and thymidine synthesis in this salvage route."", ""source_locator"": ""/comments/0/texts/0/value; /comments/1/reaction; /comments/2/texts""}]"	"[{""id"": ""MetaCyc:DEOA-CPLX"", ""source_sha256"": ""1b414dc3564b266b9e990fd5ae7486e6dbb8cca4e857045320da94e2627028c2"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DEOA-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DEOA-CPLX""}, {""id"": ""MetaCyc:THYM-PHOSPH-RXN"", ""source_sha256"": ""204139aae73f875ab995c9c129397b011527eafe9d26aeb542e2d584809be854"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native THYM-PHOSPH-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:THYM-PHOSPH-RXN""}, {""id"": ""RHEA:16039"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 16039"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P07650"", ""source_sha256"": ""6457feb8ab1f827190467c8c6bc37cc1a397f101f6dbda9e7ae0e2aa81bc1c1c"", ""source_version"": ""UniProt 2026_03; original response release header and entry audit retained"", ""title"": ""Reviewed UniProtKB P07650"", ""url"": ""https://rest.uniprot.org/uniprotkb/P07650.json""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-030_b5977e982348	MetaCyc:CPLX0-8261	pathwaymech:catalyzes	RHEA:28207	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8261|MetaCyc:DURIDKI-ENZRXN|MetaCyc:DURIDKI-RXN|PMID:17827303|RHEA:28207|UniProtKB:P23331	Native enzyme annotation is distinguished from the strain and access limits of inspected primary evidence.	"[{""reference_id"": ""MetaCyc:CPLX0-8261"", ""source_assertion"": ""The native CPLX0-8261 catalyzes annotation links DURIDKI-ENZRXN to DURIDKI-RXN."", ""source_locator"": ""Protein[@frameid='CPLX0-8261']/catalyzes/Enzymatic-Reaction[@frameid='DURIDKI-ENZRXN']/reaction/Reaction[@frameid='DURIDKI-RXN']""}, {""reference_id"": ""MetaCyc:DURIDKI-RXN"", ""source_assertion"": ""The native reaction has an explicit RHEA:28207 unification cross-reference; its own left/right compounds are retained separately from the selected Rhea direction."", ""source_locator"": ""Reaction[@frameid='DURIDKI-RXN']/dblink[dblink-db='RHEA']/dblink-oid; left; right""}, {""reference_id"": ""RHEA:28207"", ""source_assertion"": ""Rhea master 28206 explicitly lists directional member 28207; its substrates, products and equation specify the selected left-to-right transformation."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28206']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/28207']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28207']/rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""MetaCyc:DURIDKI-ENZRXN"", ""source_assertion"": ""The native deoxyuridine kinase assignment is physiologically left-to-right and carries an unpurified-protein assay evidence code linked to Hiraga 1967. This is inspected database annotation, not direct inspection of that paper."", ""source_locator"": ""Enzymatic-Reaction[@frameid='DURIDKI-ENZRXN']/enzyme; reaction; reaction-direction; evidence""}, {""reference_id"": ""UniProtKB:P23331"", ""source_assertion"": ""Reviewed UniProt states that Tdk phosphorylates both thymidine and deoxyuridine."", ""source_locator"": ""/comments/0/texts/0/value""}, {""reference_id"": ""PMID:17827303"", ""source_assertion"": ""The introduction describes deoxycytidine deamination followed by thymidine-kinase conversion of deoxyuridine to dUMP; Table 1 identifies the studied strains as K-12 derivatives."", ""source_locator"": ""Full PMC2168750 HTML Introduction paragraph beginning \""Escherichia coli has three known routes\""; Table 1 footnote a""}]"	"[{""id"": ""MetaCyc:CPLX0-8261"", ""source_sha256"": ""6a1631bda03bca1deb7fa838d9801e2982c9c1dfd5c4e61e3e98ba6008c2e76d"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native CPLX0-8261"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8261""}, {""id"": ""MetaCyc:DURIDKI-ENZRXN"", ""source_sha256"": ""3e3af6fa14d5169fe19bbc533b51805110881b403213bfab069636570aa0a7fc"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DURIDKI-ENZRXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DURIDKI-ENZRXN""}, {""id"": ""MetaCyc:DURIDKI-RXN"", ""source_sha256"": ""80d79cfa953867f840ba3cd7149de21d0cd0092181871a73dbb289dce991720a"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native DURIDKI-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DURIDKI-RXN""}, {""id"": ""PMID:17827303"", ""source_sha256"": ""0638bb23989b09ca9057114d65e818c8848547e268d2181a69eea7efa68d424f"", ""source_version"": ""2007 primary full text; mutant and K-12 strain scope retained"", ""title"": ""The Deoxycytidine Pathway for Thymidylate Synthesis in Escherichia coli"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2168750/""}, {""id"": ""RHEA:28207"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 28207"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P23331"", ""source_sha256"": ""a23c1c91bbaf4a3fdffe58d088fd72116f6034a88b252722a14f092841be8043"", ""source_version"": ""UniProt 2026_03; original response release header and entry audit retained"", ""title"": ""Reviewed UniProtKB P23331"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23331.json""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-031_a67f34a03d13	MetaCyc:CPLX0-8261	pathwaymech:catalyzes	RHEA:19130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8261|MetaCyc:THYKI-RXN|PMID:2041474|RHEA:19130	Native enzyme annotation is distinguished from the strain and access limits of inspected primary evidence.	"[{""reference_id"": ""MetaCyc:CPLX0-8261"", ""source_assertion"": ""The native CPLX0-8261 catalyzes annotation links THYKI-ENZRXN to THYKI-RXN."", ""source_locator"": ""Protein[@frameid='CPLX0-8261']/catalyzes/Enzymatic-Reaction[@frameid='THYKI-ENZRXN']/reaction/Reaction[@frameid='THYKI-RXN']""}, {""reference_id"": ""MetaCyc:THYKI-RXN"", ""source_assertion"": ""The native reaction has an explicit RHEA:19130 unification cross-reference; its own left/right compounds are retained separately from the selected Rhea direction."", ""source_locator"": ""Reaction[@frameid='THYKI-RXN']/dblink[dblink-db='RHEA']/dblink-oid; left; right""}, {""reference_id"": ""RHEA:19130"", ""source_assertion"": ""Rhea master 19129 explicitly lists directional member 19130; its substrates, products and equation specify the selected left-to-right transformation."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19129']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/19130']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/19130']/rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""PMID:2041474"", ""source_assertion"": ""W3110 DNA carrying tdk confers thymidine kinase activity on TK-deficient KY895 in the reported genetic complementation assay."", ""source_locator"": ""Europe PMC /resultList/result/0/abstractText; primary abstract only""}]"	"[{""id"": ""MetaCyc:CPLX0-8261"", ""source_sha256"": ""6a1631bda03bca1deb7fa838d9801e2982c9c1dfd5c4e61e3e98ba6008c2e76d"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native CPLX0-8261"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8261""}, {""id"": ""MetaCyc:THYKI-RXN"", ""source_sha256"": ""b8c44bfd705b0a0cc5043cadedbfdfd1b6dbb9b96eff981705395a5868494d86"", ""source_version"": ""MetaCyc 22.5 public SGD-hosted native XML"", ""title"": ""MetaCyc native THYKI-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:THYKI-RXN""}, {""id"": ""PMID:2041474"", ""source_sha256"": ""07076064f64cb10166fcf31bfa5c7ba39e18f3090d88a234772b305b1d915de6"", ""source_version"": ""Primary abstract inspected; no full-text claim"", ""title"": ""Nucleotide sequence of the Escherichia coli thymidine kinase gene provides evidence for conservation of functional domains and quaternary structure."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:2041474%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""RHEA:19130"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 19130"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-032_793782f86ff5	MetaCyc:CYTIDEAM-CPLX	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:8289286|UniProtKB:P0ABF6	Bound catalytic zinc is distinct from inhibition by excess externally supplied zinc in older assays.	"[{""reference_id"": ""UniProtKB:P0ABF6"", ""source_assertion"": ""Cdd has Zn(2+) cofactor CHEBI:29105 with experimental ECO:0000269 evidence; the note states one zinc per subunit."", ""source_locator"": ""/comments/3/cofactors; /comments/3/note/texts""}, {""reference_id"": ""PMID:8289286"", ""source_assertion"": ""The primary abstract identifies zinc-binding pockets in the cytidine deaminase dimer and the metal-ligand coordination at its active sites."", ""source_locator"": ""Europe PMC /resultList/result/0/abstractText; primary abstract only""}]"	"[{""id"": ""PMID:8289286"", ""source_sha256"": ""7070f1230543d24d3d26a7e26f40d157a88b1696f3d1e2271fadb6b823883b8e"", ""source_version"": ""Primary abstract inspected; no full-text claim"", ""title"": ""Cytidine deaminase. The 2.3 A crystal structure of an enzyme: transition-state analog complex."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8289286%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P0ABF6"", ""source_sha256"": ""ecffd6fea9810f3756dfa4dd7c17be85954ab1f19b73ad98660394b2c20a0637"", ""source_version"": ""UniProt 2026_03; original response release header and entry audit retained"", ""title"": ""Reviewed UniProtKB P0ABF6"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABF6.json""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-033_b84e81033443	RHEA:13434	BFO:0000050	GO:0010139	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0010139|PathBank:SMP0002073|RHEA:13434	The source map also includes four incoming NupC/NupG transport objects, dispositioned separately. No equivalence to the differently composed MetaCyc PWY-7199 is asserted.	"[{""reference_id"": ""PathBank:SMP0002073"", ""source_assertion"": ""The named native salvage map explicitly contains biochemical reaction 6014, whose written conversion is retained in this five-reaction biochemical implementation."", ""source_locator"": ""Pathway[@rdf:about='http://identifiers.org/smpdb/SMP0002073']/bp:pathwayComponent[@rdf:resource='#Reactions/6014']; BiochemicalReaction[@rdf:ID='Reactions/6014']/bp:left; bp:right; bp:conversionDirection""}, {""reference_id"": ""GO:0010139"", ""source_assertion"": ""GO defines recovery of pyrimidine bases or deoxyribonucleotides from nucleotide breakdown back to pyrimidine deoxyribonucleotides; this graph represents one complete E. coli biochemical implementation."", ""source_locator"": ""QuickGO /results/0/id; /results/0/name; /results/0/definition/text""}, {""reference_id"": ""RHEA:13434"", ""source_assertion"": ""Rhea master 13433 explicitly lists directional member 13434; its substrates, products and equation specify the selected left-to-right transformation."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13433']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/13434']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13434']/rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""GO:0010139"", ""source_sha256"": ""a1afd3e7b820bdff7d5de2b5e96933a60cbd63f6474a1bda13cb98bb4c7fd58e"", ""source_version"": ""QuickGO original GO term response retrieved 2026-10-11"", ""title"": ""Gene Ontology pyrimidine deoxyribonucleotide salvage"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0010139""}, {""id"": ""PathBank:SMP0002073"", ""source_sha256"": ""835dd682abc9a03bf79a4f33e415e16d23c2316b16adfc7a1aa5ba5eddffc510"", ""source_version"": ""Frozen PathBank BioPAX member PW002061.owl; member SHA scope"", ""title"": ""Salvage Pathways of Pyrimidine Deoxyribonucleotides"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:13434"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 13434"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-034_0b9fc8b448dc	RHEA:22825	BFO:0000050	GO:0010139	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0010139|PathBank:SMP0002073|RHEA:22825	The source map also includes four incoming NupC/NupG transport objects, dispositioned separately. No equivalence to the differently composed MetaCyc PWY-7199 is asserted.	"[{""reference_id"": ""PathBank:SMP0002073"", ""source_assertion"": ""The named native salvage map explicitly contains biochemical reaction 6018, whose written conversion is retained in this five-reaction biochemical implementation."", ""source_locator"": ""Pathway[@rdf:about='http://identifiers.org/smpdb/SMP0002073']/bp:pathwayComponent[@rdf:resource='#Reactions/6018']; BiochemicalReaction[@rdf:ID='Reactions/6018']/bp:left; bp:right; bp:conversionDirection""}, {""reference_id"": ""GO:0010139"", ""source_assertion"": ""GO defines recovery of pyrimidine bases or deoxyribonucleotides from nucleotide breakdown back to pyrimidine deoxyribonucleotides; this graph represents one complete E. coli biochemical implementation."", ""source_locator"": ""QuickGO /results/0/id; /results/0/name; /results/0/definition/text""}, {""reference_id"": ""RHEA:22825"", ""source_assertion"": ""Rhea master 22824 explicitly lists directional member 22825; its substrates, products and equation specify the selected left-to-right transformation."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22824']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/22825']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/22825']/rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""GO:0010139"", ""source_sha256"": ""a1afd3e7b820bdff7d5de2b5e96933a60cbd63f6474a1bda13cb98bb4c7fd58e"", ""source_version"": ""QuickGO original GO term response retrieved 2026-10-11"", ""title"": ""Gene Ontology pyrimidine deoxyribonucleotide salvage"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0010139""}, {""id"": ""PathBank:SMP0002073"", ""source_sha256"": ""835dd682abc9a03bf79a4f33e415e16d23c2316b16adfc7a1aa5ba5eddffc510"", ""source_version"": ""Frozen PathBank BioPAX member PW002061.owl; member SHA scope"", ""title"": ""Salvage Pathways of Pyrimidine Deoxyribonucleotides"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:22825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 22825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-035_3cd64f343381	RHEA:16039	BFO:0000050	GO:0010139	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0010139|PathBank:SMP0002073|RHEA:16039	The source map also includes four incoming NupC/NupG transport objects, dispositioned separately. No equivalence to the differently composed MetaCyc PWY-7199 is asserted.	"[{""reference_id"": ""PathBank:SMP0002073"", ""source_assertion"": ""The named native salvage map explicitly contains biochemical reaction 6019, whose written conversion is retained in this five-reaction biochemical implementation."", ""source_locator"": ""Pathway[@rdf:about='http://identifiers.org/smpdb/SMP0002073']/bp:pathwayComponent[@rdf:resource='#Reactions/6019']; BiochemicalReaction[@rdf:ID='Reactions/6019']/bp:left; bp:right; bp:conversionDirection""}, {""reference_id"": ""GO:0010139"", ""source_assertion"": ""GO defines recovery of pyrimidine bases or deoxyribonucleotides from nucleotide breakdown back to pyrimidine deoxyribonucleotides; this graph represents one complete E. coli biochemical implementation."", ""source_locator"": ""QuickGO /results/0/id; /results/0/name; /results/0/definition/text""}, {""reference_id"": ""RHEA:16039"", ""source_assertion"": ""Rhea master 16037 explicitly lists directional member 16039; its substrates, products and equation specify the selected right-to-left transformation."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16037']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/16039']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16039']/rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""GO:0010139"", ""source_sha256"": ""a1afd3e7b820bdff7d5de2b5e96933a60cbd63f6474a1bda13cb98bb4c7fd58e"", ""source_version"": ""QuickGO original GO term response retrieved 2026-10-11"", ""title"": ""Gene Ontology pyrimidine deoxyribonucleotide salvage"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0010139""}, {""id"": ""PathBank:SMP0002073"", ""source_sha256"": ""835dd682abc9a03bf79a4f33e415e16d23c2316b16adfc7a1aa5ba5eddffc510"", ""source_version"": ""Frozen PathBank BioPAX member PW002061.owl; member SHA scope"", ""title"": ""Salvage Pathways of Pyrimidine Deoxyribonucleotides"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:16039"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 16039"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-036_38f399618f7d	RHEA:28207	BFO:0000050	GO:0010139	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0010139|PathBank:SMP0002073|RHEA:28207	The source map also includes four incoming NupC/NupG transport objects, dispositioned separately. No equivalence to the differently composed MetaCyc PWY-7199 is asserted.	"[{""reference_id"": ""PathBank:SMP0002073"", ""source_assertion"": ""The named native salvage map explicitly contains biochemical reaction 6015, whose written conversion is retained in this five-reaction biochemical implementation."", ""source_locator"": ""Pathway[@rdf:about='http://identifiers.org/smpdb/SMP0002073']/bp:pathwayComponent[@rdf:resource='#Reactions/6015']; BiochemicalReaction[@rdf:ID='Reactions/6015']/bp:left; bp:right; bp:conversionDirection""}, {""reference_id"": ""GO:0010139"", ""source_assertion"": ""GO defines recovery of pyrimidine bases or deoxyribonucleotides from nucleotide breakdown back to pyrimidine deoxyribonucleotides; this graph represents one complete E. coli biochemical implementation."", ""source_locator"": ""QuickGO /results/0/id; /results/0/name; /results/0/definition/text""}, {""reference_id"": ""RHEA:28207"", ""source_assertion"": ""Rhea master 28206 explicitly lists directional member 28207; its substrates, products and equation specify the selected left-to-right transformation."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28206']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/28207']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28207']/rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""GO:0010139"", ""source_sha256"": ""a1afd3e7b820bdff7d5de2b5e96933a60cbd63f6474a1bda13cb98bb4c7fd58e"", ""source_version"": ""QuickGO original GO term response retrieved 2026-10-11"", ""title"": ""Gene Ontology pyrimidine deoxyribonucleotide salvage"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0010139""}, {""id"": ""PathBank:SMP0002073"", ""source_sha256"": ""835dd682abc9a03bf79a4f33e415e16d23c2316b16adfc7a1aa5ba5eddffc510"", ""source_version"": ""Frozen PathBank BioPAX member PW002061.owl; member SHA scope"", ""title"": ""Salvage Pathways of Pyrimidine Deoxyribonucleotides"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:28207"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 28207"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-037_3412877406a1	RHEA:19130	BFO:0000050	GO:0010139	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0010139|PathBank:SMP0002073|RHEA:19130	The source map also includes four incoming NupC/NupG transport objects, dispositioned separately. No equivalence to the differently composed MetaCyc PWY-7199 is asserted.	"[{""reference_id"": ""PathBank:SMP0002073"", ""source_assertion"": ""The named native salvage map explicitly contains biochemical reaction 6021, whose written conversion is retained in this five-reaction biochemical implementation."", ""source_locator"": ""Pathway[@rdf:about='http://identifiers.org/smpdb/SMP0002073']/bp:pathwayComponent[@rdf:resource='#Reactions/6021']; BiochemicalReaction[@rdf:ID='Reactions/6021']/bp:left; bp:right; bp:conversionDirection""}, {""reference_id"": ""GO:0010139"", ""source_assertion"": ""GO defines recovery of pyrimidine bases or deoxyribonucleotides from nucleotide breakdown back to pyrimidine deoxyribonucleotides; this graph represents one complete E. coli biochemical implementation."", ""source_locator"": ""QuickGO /results/0/id; /results/0/name; /results/0/definition/text""}, {""reference_id"": ""RHEA:19130"", ""source_assertion"": ""Rhea master 19129 explicitly lists directional member 19130; its substrates, products and equation specify the selected left-to-right transformation."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19129']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/19130']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/19130']/rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""GO:0010139"", ""source_sha256"": ""a1afd3e7b820bdff7d5de2b5e96933a60cbd63f6474a1bda13cb98bb4c7fd58e"", ""source_version"": ""QuickGO original GO term response retrieved 2026-10-11"", ""title"": ""Gene Ontology pyrimidine deoxyribonucleotide salvage"", ""url"": ""https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO%3A0010139""}, {""id"": ""PathBank:SMP0002073"", ""source_sha256"": ""835dd682abc9a03bf79a4f33e415e16d23c2316b16adfc7a1aa5ba5eddffc510"", ""source_version"": ""Frozen PathBank BioPAX member PW002061.owl; member SHA scope"", ""title"": ""Salvage Pathways of Pyrimidine Deoxyribonucleotides"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:19130"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 19130"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-038_bf51ea87608d	RHEA:13434	RO:0002413	RHEA:22825	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13434|RHEA:22825	Inferred material continuity from separately inspected product and substrate identities, consistent with native EcoCyc ordering; no channeling or obligatory wild-type flux claim.	"[{""reference_id"": ""RHEA:13434"", ""source_assertion"": ""The exact directed reaction 13434 produces CHEBI:16450, the shared intermediate linking these two selected transformations."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13434']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13433_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13433_compound_5154']; http://rdf.rhea-db.org/Participant_13433_compound_5154/rh:compound; http://rdf.rhea-db.org/Compound_5154/rh:chebi""}, {""reference_id"": ""RHEA:22825"", ""source_assertion"": ""The exact directed reaction 22825 consumes CHEBI:16450, the shared intermediate linking these two selected transformations."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22825']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/22824_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_22824_compound_5154']; http://rdf.rhea-db.org/Participant_22824_compound_5154/rh:compound; http://rdf.rhea-db.org/Compound_5154/rh:chebi""}]"	"[{""id"": ""RHEA:13434"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 13434"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:22825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 22825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-039_b4177f3ac2ed	RHEA:13434	RO:0002413	RHEA:28207	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13434|RHEA:28207	Inferred material continuity from separately inspected product and substrate identities, consistent with native EcoCyc ordering; no channeling or obligatory wild-type flux claim.	"[{""reference_id"": ""RHEA:13434"", ""source_assertion"": ""The exact directed reaction 13434 produces CHEBI:16450, the shared intermediate linking these two selected transformations."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/13434']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/13433_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_13433_compound_5154']; http://rdf.rhea-db.org/Participant_13433_compound_5154/rh:compound; http://rdf.rhea-db.org/Compound_5154/rh:chebi""}, {""reference_id"": ""RHEA:28207"", ""source_assertion"": ""The exact directed reaction 28207 consumes CHEBI:16450, the shared intermediate linking these two selected transformations."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28207']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28206_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28206_compound_5154']; http://rdf.rhea-db.org/Participant_28206_compound_5154/rh:compound; http://rdf.rhea-db.org/Compound_5154/rh:chebi""}]"	"[{""id"": ""RHEA:13434"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 13434"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:28207"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 28207"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-040_69547ea7878a	RHEA:22825	RO:0002413	RHEA:16039	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16039|RHEA:22825	Inferred material continuity from separately inspected product and substrate identities, consistent with native EcoCyc ordering; no channeling or obligatory wild-type flux claim.	"[{""reference_id"": ""RHEA:22825"", ""source_assertion"": ""The exact directed reaction 22825 produces CHEBI:57259, the shared intermediate linking these two selected transformations."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22825']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/22824_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_22824_compound_3098']; http://rdf.rhea-db.org/Participant_22824_compound_3098/rh:compound; http://rdf.rhea-db.org/Compound_3098/rh:chebi""}, {""reference_id"": ""RHEA:16039"", ""source_assertion"": ""The exact directed reaction 16039 consumes CHEBI:57259, the shared intermediate linking these two selected transformations."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16039']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16037_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16037_compound_3098']; http://rdf.rhea-db.org/Participant_16037_compound_3098/rh:compound; http://rdf.rhea-db.org/Compound_3098/rh:chebi""}]"	"[{""id"": ""RHEA:16039"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 16039"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:22825"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 22825"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:GO_0010139_deoxysalvage-edge-041_d89fcba883a2	RHEA:16039	RO:0002413	RHEA:19130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16039|RHEA:19130	Inferred material continuity from separately inspected product and substrate identities, consistent with native EcoCyc ordering; no channeling or obligatory wild-type flux claim.	"[{""reference_id"": ""RHEA:16039"", ""source_assertion"": ""The exact directed reaction 16039 produces CHEBI:17748, the shared intermediate linking these two selected transformations."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16039']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16037_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16037_compound_4636']; http://rdf.rhea-db.org/Participant_16037_compound_4636/rh:compound; http://rdf.rhea-db.org/Compound_4636/rh:chebi""}, {""reference_id"": ""RHEA:19130"", ""source_assertion"": ""The exact directed reaction 19130 consumes CHEBI:17748, the shared intermediate linking these two selected transformations."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/19130']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/19129_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_19129_compound_4636']; http://rdf.rhea-db.org/Participant_19129_compound_4636/rh:compound; http://rdf.rhea-db.org/Compound_4636/rh:chebi""}]"	"[{""id"": ""RHEA:16039"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 16039"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:19130"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; complete native RDF gzip"", ""title"": ""Rhea exact directed reaction 19130"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-001_3a5a9b70f438	CHEBI:60873	pathwaymech:consumes	RHEA:27879	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27879		"[{""reference_id"": ""RHEA:27879"", ""source_assertion"": ""Rhea 27879 assigns CHEBI:60873 to substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27879']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27878_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27878_compound_6281']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27879"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27879 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-002_3f245e2dfa44	CHEBI:15377	pathwaymech:consumes	RHEA:27879	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27879		"[{""reference_id"": ""RHEA:27879"", ""source_assertion"": ""Rhea 27879 assigns CHEBI:15377 to substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27879']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27878_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27878_compound_1283']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27879"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27879 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-003_7736264a3360	RHEA:27879	pathwaymech:produces	CHEBI:60784	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27879		"[{""reference_id"": ""RHEA:27879"", ""source_assertion"": ""Rhea 27879 assigns CHEBI:60784 to products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27879']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27878_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27878_compound_6282']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27879"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27879 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-004_4fdfb0ad46dd	RHEA:27879	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27879		"[{""reference_id"": ""RHEA:27879"", ""source_assertion"": ""Rhea 27879 assigns CHEBI:15378 to products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27879']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27878_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27878_compound_3249']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27879"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27879 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-005_908be23fff36	CHEBI:60784	pathwaymech:consumes	RHEA:27891	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27891		"[{""reference_id"": ""RHEA:27891"", ""source_assertion"": ""Rhea 27891 assigns CHEBI:60784 to substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27891']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27890_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27890_compound_6282']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27891"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27891 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-006_b5dfd8cca3fa	CHEBI:15377	pathwaymech:consumes	RHEA:27891	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27891		"[{""reference_id"": ""RHEA:27891"", ""source_assertion"": ""Rhea 27891 assigns CHEBI:15377 to substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27891']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27890_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27890_compound_1283']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27891"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27891 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-007_b45734879743	RHEA:27891	pathwaymech:produces	CHEBI:16704	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27891		"[{""reference_id"": ""RHEA:27891"", ""source_assertion"": ""Rhea 27891 assigns CHEBI:16704 to products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27891']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27890_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27890_compound_4178']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27891"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27891 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-008_6647d6e69f4e	RHEA:27891	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27891		"[{""reference_id"": ""RHEA:27891"", ""source_assertion"": ""Rhea 27891 assigns CHEBI:43474 to products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27891']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27890_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27890_compound_5518']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27891"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27891 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-009_b1359b606ce7	CHEBI:17562	pathwaymech:consumes	RHEA:16070	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16070		"[{""reference_id"": ""RHEA:16070"", ""source_assertion"": ""Rhea 16070 assigns CHEBI:17562 to substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16070']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16069_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16069_compound_3062']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:16070"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 16070 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-010_966661712882	CHEBI:15377	pathwaymech:consumes	RHEA:16070	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16070		"[{""reference_id"": ""RHEA:16070"", ""source_assertion"": ""Rhea 16070 assigns CHEBI:15377 to substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16070']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16069_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16069_compound_1283']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:16070"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 16070 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-011_a7b3aa52c9e5	CHEBI:15378	pathwaymech:consumes	RHEA:16070	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16070		"[{""reference_id"": ""RHEA:16070"", ""source_assertion"": ""Rhea 16070 assigns CHEBI:15378 to substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16070']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16069_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16069_compound_3249']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:16070"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 16070 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-012_f712bb43ffcf	RHEA:16070	pathwaymech:produces	CHEBI:16704	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16070		"[{""reference_id"": ""RHEA:16070"", ""source_assertion"": ""Rhea 16070 assigns CHEBI:16704 to products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16070']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16069_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16069_compound_4178']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:16070"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 16070 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-013_facea21b26a9	RHEA:16070	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:16070		"[{""reference_id"": ""RHEA:16070"", ""source_assertion"": ""Rhea 16070 assigns CHEBI:28938 to products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16070']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16069_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_16069_compound_1012']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:16070"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 16070 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-014_f3f60174e9f7	CHEBI:16704	pathwaymech:consumes	RHEA:24389	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24389		"[{""reference_id"": ""RHEA:24389"", ""source_assertion"": ""Rhea 24389 assigns CHEBI:16704 to substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24389']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24388_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24388_compound_4178']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:24389"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 24389 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-015_4f68fc3f7b6d	CHEBI:43474	pathwaymech:consumes	RHEA:24389	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24389		"[{""reference_id"": ""RHEA:24389"", ""source_assertion"": ""Rhea 24389 assigns CHEBI:43474 to substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24389']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24388_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24388_compound_5518']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:24389"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 24389 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-016_7f6cc23be357	RHEA:24389	pathwaymech:produces	CHEBI:57720	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24389		"[{""reference_id"": ""RHEA:24389"", ""source_assertion"": ""Rhea 24389 assigns CHEBI:57720 to products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24389']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24388_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24388_compound_2276']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:24389"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 24389 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-017_275d1ce312ef	RHEA:24389	pathwaymech:produces	CHEBI:17568	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24389		"[{""reference_id"": ""RHEA:24389"", ""source_assertion"": ""Rhea 24389 assigns CHEBI:17568 to products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24389']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24388_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_24388_compound_4063']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:24389"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 24389 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-018_76b2e4143e93	CHEBI:57720	pathwaymech:consumes	RHEA:18794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18794		"[{""reference_id"": ""RHEA:18794"", ""source_assertion"": ""Rhea 18794 assigns CHEBI:57720 to substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18794']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/18793_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_18793_compound_2276']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:18794"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 18794 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-019_6f70b67b75f1	RHEA:18794	pathwaymech:produces	CHEBI:78346	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18794		"[{""reference_id"": ""RHEA:18794"", ""source_assertion"": ""Rhea 18794 assigns CHEBI:78346 to products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18794']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/18793_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_18793_compound_9495']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:18794"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 18794 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-020_28a683027f9c	PathBank:SMP0002038/Compound/PW_C000202_Periplasmic_Space	pathwaymech:consumes	RHEA:29953	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002038|RHEA:29953		"[{""reference_id"": ""RHEA:29953"", ""source_assertion"": ""Rhea 29953 assigns CHEBI:16704 to substrates with coefficient 1; the participant is explicitly Out."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/29953']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/29951_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_29951_compound_4178_out']; rh:compound/rh:chebi; rh:location""}, {""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Native transport 488 assigns this exact Periplasmic_Space physical object to its left side; the entity reference and compartment distinguish it from the corresponding state across the membrane."", ""source_locator"": ""bp:Transport[@rdf:ID='Transports/488']/bp:left; bp:SmallMolecule[@rdf:ID='Compound/PW_C000202_Periplasmic_Space']/bp:entityReference; bp:cellularLocation""}]"	"[{""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}, {""id"": ""RHEA:29953"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 29953 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-021_000558c43da1	PathBank:SMP0002038/Compound/PW_C040034_Periplasmic_Space	pathwaymech:consumes	RHEA:29953	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002038|RHEA:29953		"[{""reference_id"": ""RHEA:29953"", ""source_assertion"": ""Rhea 29953 assigns CHEBI:15378 to substrates with coefficient 1; the participant is explicitly Out."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/29953']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/29951_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_29951_compound_3249_out']; rh:compound/rh:chebi; rh:location""}, {""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Native transport 488 assigns this exact Periplasmic_Space physical object to its left side; the entity reference and compartment distinguish it from the corresponding state across the membrane."", ""source_locator"": ""bp:Transport[@rdf:ID='Transports/488']/bp:left; bp:SmallMolecule[@rdf:ID='Compound/PW_C040034_Periplasmic_Space']/bp:entityReference; bp:cellularLocation""}]"	"[{""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}, {""id"": ""RHEA:29953"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 29953 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-022_433ab0b985f8	RHEA:29953	pathwaymech:produces	PathBank:SMP0002038/Compound/PW_C000202_Cytosol	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002038|RHEA:29953		"[{""reference_id"": ""RHEA:29953"", ""source_assertion"": ""Rhea 29953 assigns CHEBI:16704 to products with coefficient 1; the participant is explicitly In."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/29953']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/29951_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_29951_compound_4178_in']; rh:compound/rh:chebi; rh:location""}, {""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Native transport 488 assigns this exact Cytosol physical object to its right side; the entity reference and compartment distinguish it from the corresponding state across the membrane."", ""source_locator"": ""bp:Transport[@rdf:ID='Transports/488']/bp:right; bp:SmallMolecule[@rdf:ID='Compound/PW_C000202_Cytosol']/bp:entityReference; bp:cellularLocation""}]"	"[{""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}, {""id"": ""RHEA:29953"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 29953 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-023_fcb6df751a14	RHEA:29953	pathwaymech:produces	PathBank:SMP0002038/Compound/PW_C040034_Cytosol	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002038|RHEA:29953		"[{""reference_id"": ""RHEA:29953"", ""source_assertion"": ""Rhea 29953 assigns CHEBI:15378 to products with coefficient 1; the participant is explicitly In."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/29953']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/29951_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_29951_compound_3249_in']; rh:compound/rh:chebi; rh:location""}, {""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Native transport 488 assigns this exact Cytosol physical object to its right side; the entity reference and compartment distinguish it from the corresponding state across the membrane."", ""source_locator"": ""bp:Transport[@rdf:ID='Transports/488']/bp:right; bp:SmallMolecule[@rdf:ID='Compound/PW_C040034_Cytosol']/bp:entityReference; bp:cellularLocation""}]"	"[{""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}, {""id"": ""RHEA:29953"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 29953 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-024_d8595d6a0eba	PathBank:SMP0002038/Compound/PW_C000061_Periplasmic_Space	pathwaymech:consumes	RHEA:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002038|RHEA:29985		"[{""reference_id"": ""RHEA:29985"", ""source_assertion"": ""Rhea 29985 assigns CHEBI:17562 to substrates with coefficient 1; the participant is explicitly Out."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/29985']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/29983_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_29983_compound_3062_out']; rh:compound/rh:chebi; rh:location""}, {""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Native transport 489 assigns this exact Periplasmic_Space physical object to its left side; the entity reference and compartment distinguish it from the corresponding state across the membrane."", ""source_locator"": ""bp:Transport[@rdf:ID='Transports/489']/bp:left; bp:SmallMolecule[@rdf:ID='Compound/PW_C000061_Periplasmic_Space']/bp:entityReference; bp:cellularLocation""}]"	"[{""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}, {""id"": ""RHEA:29985"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 29985 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-025_7a89eb4566dd	PathBank:SMP0002038/Compound/PW_C040034_Periplasmic_Space	pathwaymech:consumes	RHEA:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002038|RHEA:29985		"[{""reference_id"": ""RHEA:29985"", ""source_assertion"": ""Rhea 29985 assigns CHEBI:15378 to substrates with coefficient 1; the participant is explicitly Out."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/29985']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/29983_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_29983_compound_3249_out']; rh:compound/rh:chebi; rh:location""}, {""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Native transport 489 assigns this exact Periplasmic_Space physical object to its left side; the entity reference and compartment distinguish it from the corresponding state across the membrane."", ""source_locator"": ""bp:Transport[@rdf:ID='Transports/489']/bp:left; bp:SmallMolecule[@rdf:ID='Compound/PW_C040034_Periplasmic_Space']/bp:entityReference; bp:cellularLocation""}]"	"[{""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}, {""id"": ""RHEA:29985"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 29985 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-026_e4aa64f95466	RHEA:29985	pathwaymech:produces	PathBank:SMP0002038/Compound/PW_C000061_Cytosol	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002038|RHEA:29985		"[{""reference_id"": ""RHEA:29985"", ""source_assertion"": ""Rhea 29985 assigns CHEBI:17562 to products with coefficient 1; the participant is explicitly In."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/29985']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/29983_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_29983_compound_3062_in']; rh:compound/rh:chebi; rh:location""}, {""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Native transport 489 assigns this exact Cytosol physical object to its right side; the entity reference and compartment distinguish it from the corresponding state across the membrane."", ""source_locator"": ""bp:Transport[@rdf:ID='Transports/489']/bp:right; bp:SmallMolecule[@rdf:ID='Compound/PW_C000061_Cytosol']/bp:entityReference; bp:cellularLocation""}]"	"[{""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}, {""id"": ""RHEA:29985"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 29985 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-027_8ca12913a1d9	RHEA:29985	pathwaymech:produces	PathBank:SMP0002038/Compound/PW_C040034_Cytosol	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002038|RHEA:29985		"[{""reference_id"": ""RHEA:29985"", ""source_assertion"": ""Rhea 29985 assigns CHEBI:15378 to products with coefficient 1; the participant is explicitly In."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/29985']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/29983_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_29983_compound_3249_in']; rh:compound/rh:chebi; rh:location""}, {""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Native transport 489 assigns this exact Cytosol physical object to its right side; the entity reference and compartment distinguish it from the corresponding state across the membrane."", ""source_locator"": ""bp:Transport[@rdf:ID='Transports/489']/bp:right; bp:SmallMolecule[@rdf:ID='Compound/PW_C040034_Cytosol']/bp:entityReference; bp:cellularLocation""}]"	"[{""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}, {""id"": ""RHEA:29985"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 29985 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-028_e2ff057dd906	UniProtKB:P08331	pathwaymech:enables	RHEA:27879	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPDB-MONOMER|PMID:27294396|PMID:6251162|PathBank:SMP0002038|RHEA:27879		"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Native ReactionCatalysis/5858 assigns its protein controller to Reactions/5895; the component or protein reference identifies UniProtKB:P08331."", ""source_locator"": ""bp:Catalysis[@rdf:ID='ReactionCatalysis/5858']/bp:controller and bp:controlled; bp:ProteinReference[@rdf:ID='ProteinReference/5948']/bp:xref""}, {""reference_id"": ""RHEA:27879"", ""source_assertion"": ""The explicit Rhea family maps master 27878 to directional member 27879; inspected sides and equation match the selected native chemistry."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27878']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/27879']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27879']/rh:substrates, rh:products, rh:equation""}, {""reference_id"": ""MetaCyc:CPDB-MONOMER"", ""source_assertion"": ""Native CpdB annotation links this exact uridine reaction RXN-14091 to CPDB-MONOMER; its UNIPROT unification is P08331."", ""source_locator"": ""Protein[@frameid='CPDB-MONOMER']/catalyzes/Enzymatic-Reaction/reaction/Reaction[@frameid='RXN-14091']; dblink[dblink-db='UNIPROT']""}, {""reference_id"": ""PMID:6251162"", ""source_assertion"": ""K-12 cpdB mutants lose most cyclic-UMP and 3′-UMP hydrolysis; the paper explicitly describes the two-step route to uridine. Residual 3′-nucleotidase activity and pyrE-dependent growth selection prevent an exclusivity or wild-type-flux claim."", ""source_locator"": ""Printed pp31–32, Methods; Tables1–2; Results and Discussion, first two paragraphs""}, {""reference_id"": ""PMID:27294396"", ""source_assertion"": ""Recombinant BL21 CpdB hydrolyzed cyclic UMP in a coupled phosphate assay. Table1 does not independently establish the uridine-product regiochemistry or K-12 whole-pathway flux."", ""source_locator"": ""Methods, Bacterial strains and Enzyme activity assays; Table1 cyclic-UMP row; Results, Enzymatic characterization""}]"	"[{""id"": ""MetaCyc:CPDB-MONOMER"", ""source_sha256"": ""577c2bb6713b61a4af3c8ae949237f6ec018d8ac0049b3846e02bc16b29ea010"", ""source_version"": ""22.5; native mirror retrieved 2026-10-11"", ""title"": ""MetaCyc CPDB-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPDB-MONOMER""}, {""id"": ""PMID:27294396"", ""source_sha256"": ""cb040e308ae5e49c7bef13e69069c28a2cb7850f93c038f696e104a41da92a2d"", ""source_version"": ""Primary full text; retrieved2026-10-11"", ""title"": ""Biochemical characterization of recombinant E. coli CpdB."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4905662/fullTextXML""}, {""id"": ""PMID:6251162"", ""source_sha256"": ""80865ad2c966129308417a751f10957e19568bd736ac26f5974e1623f1abf6e3"", ""source_version"": ""1980 primary full paper; author-repository scan inspected pp31–34, Table2 visually checked; retrieved2026-10-11"", ""title"": ""Isolation of Escherichia coli mutants (cpdB) deficient in periplasmic cyclic phosphodiesterase."", ""url"": ""https://doi.org/10.1099/00221287-119-1-31""}, {""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}, {""id"": ""RHEA:27879"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27879 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-029_68421e77ad15	UniProtKB:P08331	pathwaymech:enables	RHEA:27891	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPDB-MONOMER|PMID:6251162|PathBank:SMP0002038|RHEA:27891		"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Native ReactionCatalysis/5859 assigns its protein controller to Reactions/5896; the component or protein reference identifies UniProtKB:P08331."", ""source_locator"": ""bp:Catalysis[@rdf:ID='ReactionCatalysis/5859']/bp:controller and bp:controlled; bp:ProteinReference[@rdf:ID='ProteinReference/5948']/bp:xref""}, {""reference_id"": ""RHEA:27891"", ""source_assertion"": ""The explicit Rhea family maps master 27890 to directional member 27891; inspected sides and equation match the selected native chemistry."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27890']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/27891']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27891']/rh:substrates, rh:products, rh:equation""}, {""reference_id"": ""MetaCyc:CPDB-MONOMER"", ""source_assertion"": ""Native CpdB annotation links this exact uridine reaction RXN-14115 to CPDB-MONOMER; its UNIPROT unification is P08331."", ""source_locator"": ""Protein[@frameid='CPDB-MONOMER']/catalyzes/Enzymatic-Reaction/reaction/Reaction[@frameid='RXN-14115']; dblink[dblink-db='UNIPROT']""}, {""reference_id"": ""PMID:6251162"", ""source_assertion"": ""K-12 cpdB mutants lose most cyclic-UMP and 3′-UMP hydrolysis; the paper explicitly describes the two-step route to uridine. Residual 3′-nucleotidase activity and pyrE-dependent growth selection prevent an exclusivity or wild-type-flux claim."", ""source_locator"": ""Printed pp31–32, Methods; Tables1–2; Results and Discussion, first two paragraphs""}]"	"[{""id"": ""MetaCyc:CPDB-MONOMER"", ""source_sha256"": ""577c2bb6713b61a4af3c8ae949237f6ec018d8ac0049b3846e02bc16b29ea010"", ""source_version"": ""22.5; native mirror retrieved 2026-10-11"", ""title"": ""MetaCyc CPDB-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPDB-MONOMER""}, {""id"": ""PMID:6251162"", ""source_sha256"": ""80865ad2c966129308417a751f10957e19568bd736ac26f5974e1623f1abf6e3"", ""source_version"": ""1980 primary full paper; author-repository scan inspected pp31–34, Table2 visually checked; retrieved2026-10-11"", ""title"": ""Isolation of Escherichia coli mutants (cpdB) deficient in periplasmic cyclic phosphodiesterase."", ""url"": ""https://doi.org/10.1099/00221287-119-1-31""}, {""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}, {""id"": ""RHEA:27891"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27891 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-030_ca4119a52cf7	MetaCyc:CYTIDEAM-CPLX	pathwaymech:catalyzes	RHEA:16070	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:4202859|PathBank:SMP0002038|RHEA:16070|UniProtKB:P0ABF6		"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Native ReactionCatalysis/5860 assigns its protein complex controller to Reactions/5897; the component or protein reference identifies UniProtKB:P0ABF6."", ""source_locator"": ""bp:Catalysis[@rdf:ID='ReactionCatalysis/5860']/bp:controller and bp:controlled; bp:ProteinReference[@rdf:ID='ProteinReference/6175']/bp:xref""}, {""reference_id"": ""RHEA:16070"", ""source_assertion"": ""The explicit Rhea family maps master 16069 to directional member 16070; inspected sides and equation match the selected native chemistry."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/16069']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/16070']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/16070']/rh:substrates, rh:products, rh:equation""}, {""reference_id"": ""UniProtKB:P0ABF6"", ""source_assertion"": ""The reviewed K-12 entry assigns cytidine deamination and a homodimeric assembly; the exact cytidine reaction, not the deoxy substrate activity, is selected."", ""source_locator"": ""comments[1].reaction; SUBUNIT comment; organism.taxonId""}, {""reference_id"": ""PMID:4202859"", ""source_assertion"": ""Purified E. coli cytidine deaminase uses cytidine as substrate; the assay distinguishes cytidine from deoxycytidine. The enzyme came from mutant Y70-272, not a wild-type MG1655 flux experiment."", ""source_locator"": ""Printed pp798–799, purification and bacterial strain; TableVI cytidine row""}]"	"[{""id"": ""PMID:4202859"", ""source_sha256"": ""d094077fc2c51687a68d397866a9bc3f54aff1c42ea120a602b9b1dcb0f7aed4"", ""source_version"": ""1973 primary full text, pp.797-803"", ""title"": ""The purification and properties of cytidine deaminase from Escherichia coli."", ""url"": ""https://www.jstage.jst.go.jp/article/biochemistry1922/74/4/74_4_797/_pdf""}, {""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}, {""id"": ""RHEA:16070"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 16070 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0ABF6"", ""source_sha256"": ""ecffd6fea9810f3756dfa4dd7c17be85954ab1f19b73ad98660394b2c20a0637"", ""source_version"": ""2026_03; actual X-UniProt-Release header; retrieved 2026-10-11"", ""title"": ""Reviewed UniProtKB P0ABF6"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABF6.json""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-031_e388b68d350f	MetaCyc:URPHOS-CPLX	pathwaymech:catalyzes	RHEA:24389	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:16751|PathBank:SMP0002038|RHEA:24389|UniProtKB:P12758		"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Native ReactionCatalysis/5861 assigns its protein complex controller to Reactions/5898; the component or protein reference identifies UniProtKB:P12758."", ""source_locator"": ""bp:Catalysis[@rdf:ID='ReactionCatalysis/5861']/bp:controller and bp:controlled; bp:ProteinReference[@rdf:ID='ProteinReference/10357']/bp:xref""}, {""reference_id"": ""RHEA:24389"", ""source_assertion"": ""The explicit Rhea family maps master 24388 to directional member 24389; inspected sides and equation match the selected native chemistry."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24388']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/24389']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/24389']/rh:substrates, rh:products, rh:equation""}, {""reference_id"": ""UniProtKB:P12758"", ""source_assertion"": ""The reviewed K-12 Udp entry assigns uridine phosphorolysis through RHEA:24388 and a homohexamer; weaker deoxynucleoside activities are outside this selected route."", ""source_locator"": ""CATALYTIC ACTIVITY and SUBUNIT comments; organism.taxonId""}, {""reference_id"": ""PMID:16751"", ""source_assertion"": ""Purified E. coli uridine phosphorylase showed uridine activity and no cytidine activity. Its historical eight-subunit estimate is not adopted; current hexamer evidence is recorded separately."", ""source_locator"": ""Primary abstract, specific activity, substrate specificity and molecular weight sentences""}]"	"[{""id"": ""PMID:16751"", ""source_sha256"": ""dde5126e227a8e93cf8edbe176da3568c67c877f076610a85549cb584b8ddcc5"", ""source_version"": ""Primary abstract only; Europe PMC core response retrieved2026-10-11"", ""title"": ""Uridine phosphorylase from Escherichia coli. Physical and chemical characterization."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/16751/""}, {""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}, {""id"": ""RHEA:24389"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 24389 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P12758"", ""source_sha256"": ""d9b0e2f3d5f330eed893f300120e66179abed88c2e5f870fe4fd75a30b11a153"", ""source_version"": ""2026_03; actual X-UniProt-Release header; retrieved 2026-10-11"", ""title"": ""Reviewed UniProtKB P12758"", ""url"": ""https://rest.uniprot.org/uniprotkb/P12758.json""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-032_4f0f6b70c824	UniProtKB:P0A6K6	pathwaymech:enables	RHEA:18794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:1089430|PathBank:SMP0002038|RHEA:18794|UniProtKB:P0A6K6		"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Native ReactionCatalysis/5862 assigns its protein controller to Reactions/5899; the component or protein reference identifies UniProtKB:P0A6K6."", ""source_locator"": ""bp:Catalysis[@rdf:ID='ReactionCatalysis/5862']/bp:controller and bp:controlled; bp:ProteinReference[@rdf:ID='ProteinReference/6000']/bp:xref""}, {""reference_id"": ""RHEA:18794"", ""source_assertion"": ""The explicit Rhea family maps master 18793 to directional member 18794; inspected sides and equation match the selected native chemistry."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18793']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/18794']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/18794']/rh:substrates, rh:products, rh:equation""}, {""reference_id"": ""UniProtKB:P0A6K6"", ""source_assertion"": ""The reviewed K-12 DeoB entry directly annotates alpha-D-ribose1-phosphate to D-ribose5-phosphate, RHEA:18793, with experimental citations1089430 and4992818."", ""source_locator"": ""comments[2].reaction and evidences; organism.taxonId""}, {""reference_id"": ""PMID:1089430"", ""source_assertion"": ""The primary abstract reports purified E. coli enzyme as four modified forms of a single45-kDa chain. This supports an enzyme-function assignment without introducing a new complex."", ""source_locator"": ""Primary abstract, molecular weight and single polypeptide chain sentences""}]"	"[{""id"": ""PMID:1089430"", ""source_sha256"": ""4cefa8da9e7218bc732c7817e70f5fab8667528ac85c75006573228df25c0be3"", ""source_version"": ""Primary abstract only; Europe PMC core response retrieved2026-10-11"", ""title"": ""Multiple forms of phosphodeoxyribomutase from Escherichia coli. Physical and chemical characterization."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/1089430/""}, {""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}, {""id"": ""RHEA:18794"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 18794 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0A6K6"", ""source_sha256"": ""832643bbf42bfcb2ef2e5598e24ff7f18f224bde94291d56a8d5a61bed4b3d66"", ""source_version"": ""2026_03; actual X-UniProt-Release header; retrieved 2026-10-11"", ""title"": ""Reviewed UniProtKB P0A6K6"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6K6.json""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-033_7f41ad01a757	UniProtKB:P0AFF4	pathwaymech:enables	RHEA:29953	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:15513740|PMID:33640454|PathBank:SMP0002038|RHEA:29953|UniProtKB:P0AFF4		"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Native TransportCatalysis/420 assigns its protein controller to Transports/488; the component or protein reference identifies UniProtKB:P0AFF4."", ""source_locator"": ""bp:Catalysis[@rdf:ID='TransportCatalysis/420']/bp:controller and bp:controlled; bp:ProteinReference[@rdf:ID='ProteinReference/7058']/bp:xref""}, {""reference_id"": ""RHEA:29953"", ""source_assertion"": ""The explicit Rhea family maps master 29951 to directional member 29953; inspected sides and equation match the selected native chemistry."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/29951']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/29953']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/29953']/rh:substrates, rh:products, rh:equation""}, {""reference_id"": ""UniProtKB:P0AFF4"", ""source_assertion"": ""The reviewed K-12 NupG entry assigns this nucleoside/H+ transport family with direct literature support. The native pathway selects import; the master equation is oriented in-to-out."", ""source_locator"": ""CATALYTIC ACTIVITY reactionCrossReferences RHEA:29951; FUNCTION comment; organism.taxonId""}, {""reference_id"": ""PMID:15513740"", ""source_assertion"": ""Recombinant NupG transported uridine; competition, oocyte uptake and reconstitution supported broad nucleoside transport energized by proton motive force. This does not quantify native pathway flux or prove an exclusive transporter."", ""source_locator"": ""Primary abstract, transport, specificity and reconstitution sentences""}, {""reference_id"": ""PMID:33640454"", ""source_assertion"": ""K12-derived NupG expressed in C43(DE3) bound uridine and cytidine in vitro. These binding and apo-structure measurements support recognition, not direct flux or proton:nucleoside stoichiometry."", ""source_locator"": ""Results, Characterization of recombinant NupG, Figure1D/F; Experimental procedures, Protein purification""}]"	"[{""id"": ""PMID:15513740"", ""source_sha256"": ""c929466426545c0e5623ac87c11b5d96cf8da4a9150992d7a0e346ee6f5f7f03"", ""source_version"": ""Primary abstract only; Europe PMC core response retrieved2026-10-11"", ""title"": ""Purification and properties of the Escherichia coli nucleoside transporter NupG, a paradigm for a major facilitator transporter sub-family."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/15513740/""}, {""id"": ""PMID:33640454"", ""source_sha256"": ""1231b772f3c063f906b2398cc82e9a0d69a9294a4681b10a6455f58c2d0d31f5"", ""source_version"": ""Primary full text; retrieved2026-10-11"", ""title"": ""Molecular basis for substrate recognition by bacterial NupG."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8042404/fullTextXML""}, {""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}, {""id"": ""RHEA:29953"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 29953 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0AFF4"", ""source_sha256"": ""9243c3ca2a5ecd5f1c1cb0bc6d5affc2561425a0ae9ee62f323f17925d3b2b27"", ""source_version"": ""2026_03; actual X-UniProt-Release header; retrieved 2026-10-11"", ""title"": ""Reviewed UniProtKB P0AFF4"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AFF4.json""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-034_f4c686e77772	UniProtKB:P0AFF4	pathwaymech:enables	RHEA:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:15513740|PMID:33640454|PathBank:SMP0002038|RHEA:29985|UniProtKB:P0AFF4		"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Native TransportCatalysis/421 assigns its protein controller to Transports/489; the component or protein reference identifies UniProtKB:P0AFF4."", ""source_locator"": ""bp:Catalysis[@rdf:ID='TransportCatalysis/421']/bp:controller and bp:controlled; bp:ProteinReference[@rdf:ID='ProteinReference/7058']/bp:xref""}, {""reference_id"": ""RHEA:29985"", ""source_assertion"": ""The explicit Rhea family maps master 29983 to directional member 29985; inspected sides and equation match the selected native chemistry."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/29983']/rh:directionalReaction[@rdf:resource='http://rdf.rhea-db.org/29985']; rdf:Description[@rdf:about='http://rdf.rhea-db.org/29985']/rh:substrates, rh:products, rh:equation""}, {""reference_id"": ""UniProtKB:P0AFF4"", ""source_assertion"": ""The reviewed K-12 NupG entry assigns this nucleoside/H+ transport family with direct literature support. The native pathway selects import; the master equation is oriented in-to-out."", ""source_locator"": ""CATALYTIC ACTIVITY reactionCrossReferences RHEA:29983; FUNCTION comment; organism.taxonId""}, {""reference_id"": ""PMID:15513740"", ""source_assertion"": ""Recombinant NupG transported uridine; competition, oocyte uptake and reconstitution supported broad nucleoside transport energized by proton motive force. This does not quantify native pathway flux or prove an exclusive transporter."", ""source_locator"": ""Primary abstract, transport, specificity and reconstitution sentences""}, {""reference_id"": ""PMID:33640454"", ""source_assertion"": ""K12-derived NupG expressed in C43(DE3) bound uridine and cytidine in vitro. These binding and apo-structure measurements support recognition, not direct flux or proton:nucleoside stoichiometry."", ""source_locator"": ""Results, Characterization of recombinant NupG, Figure1D/F; Experimental procedures, Protein purification""}]"	"[{""id"": ""PMID:15513740"", ""source_sha256"": ""c929466426545c0e5623ac87c11b5d96cf8da4a9150992d7a0e346ee6f5f7f03"", ""source_version"": ""Primary abstract only; Europe PMC core response retrieved2026-10-11"", ""title"": ""Purification and properties of the Escherichia coli nucleoside transporter NupG, a paradigm for a major facilitator transporter sub-family."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/15513740/""}, {""id"": ""PMID:33640454"", ""source_sha256"": ""1231b772f3c063f906b2398cc82e9a0d69a9294a4681b10a6455f58c2d0d31f5"", ""source_version"": ""Primary full text; retrieved2026-10-11"", ""title"": ""Molecular basis for substrate recognition by bacterial NupG."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8042404/fullTextXML""}, {""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}, {""id"": ""RHEA:29985"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 29985 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0AFF4"", ""source_sha256"": ""9243c3ca2a5ecd5f1c1cb0bc6d5affc2561425a0ae9ee62f323f17925d3b2b27"", ""source_version"": ""2026_03; actual X-UniProt-Release header; retrieved 2026-10-11"", ""title"": ""Reviewed UniProtKB P0AFF4"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AFF4.json""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-035_7018a3f3d64c	MetaCyc:CYTIDEAM-CPLX	BFO:0000051	UniProtKB:P0ABF6	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002038|UniProtKB:P0ABF6	Native homo-oligomer with 2 copies; membership is distinct from monomer activity.	"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Native complex 3973 contains 2 copies of protein 6175, whose protein reference unifies with UniProtKB:P0ABF6."", ""source_locator"": ""bp:Complex[@rdf:ID='ProteinComplex/3973']/bp:component and bp:componentStoichiometry; bp:Stoichiometry[@rdf:ID='Protein/6175/Stoichiometry/2.0']; bp:ProteinReference[@rdf:ID='ProteinReference/6175']/bp:xref""}, {""reference_id"": ""UniProtKB:P0ABF6"", ""source_assertion"": ""The current reviewed SUBUNIT annotation independently supports this homo-oligomeric assembly."", ""source_locator"": ""SUBUNIT comment""}]"	"[{""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}, {""id"": ""UniProtKB:P0ABF6"", ""source_sha256"": ""ecffd6fea9810f3756dfa4dd7c17be85954ab1f19b73ad98660394b2c20a0637"", ""source_version"": ""2026_03; actual X-UniProt-Release header; retrieved 2026-10-11"", ""title"": ""Reviewed UniProtKB P0ABF6"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABF6.json""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-036_f79c5caaca4d	MetaCyc:URPHOS-CPLX	BFO:0000051	UniProtKB:P12758	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:URPHOS-CPLX|PMID:12499542|PathBank:SMP0002038|UniProtKB:P12758	Native homo-oligomer with 6 copies; membership is distinct from monomer activity.	"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Native complex 3974 contains 6 copies of protein 10357, whose protein reference unifies with UniProtKB:P12758."", ""source_locator"": ""bp:Complex[@rdf:ID='ProteinComplex/3974']/bp:component and bp:componentStoichiometry; bp:Stoichiometry[@rdf:ID='Protein/10357/Stoichiometry/6.0']; bp:ProteinReference[@rdf:ID='ProteinReference/10357']/bp:xref""}, {""reference_id"": ""UniProtKB:P12758"", ""source_assertion"": ""The current reviewed SUBUNIT annotation independently supports this homo-oligomeric assembly."", ""source_locator"": ""SUBUNIT comment""}, {""reference_id"": ""MetaCyc:URPHOS-CPLX"", ""source_assertion"": ""Native URPHOS-CPLX contains six URPHOS-MONOMER components."", ""source_locator"": ""Protein[@frameid=\""URPHOS-CPLX\""]/component""}, {""reference_id"": ""PMID:12499542"", ""source_assertion"": ""The structural study identifies native uridine phosphorylase as a hexamer assembled by threefold symmetry; this supports the current assignment over the older eight-subunit estimate."", ""source_locator"": ""Primary abstract, native hexameric UP assembly sentence""}]"	"[{""id"": ""MetaCyc:URPHOS-CPLX"", ""source_sha256"": ""ed9bdb933e3a1b81989462ca331879af71ecd9fe4213074cc94df22f7da037b2"", ""source_version"": ""22.5; native mirror retrieved 2026-10-11"", ""title"": ""MetaCyc URPHOS-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:URPHOS-CPLX""}, {""id"": ""PMID:12499542"", ""source_sha256"": ""5dd56da5e1131e179af3c83fda4c7cb3ea9cc8400407ce4fa14158876324ef64"", ""source_version"": ""2003 primary abstract only; Europe PMC core response retrieved2026-10-11"", ""title"": ""Structure of Escherichia coli uridine phosphorylase at2.0A."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12499542/""}, {""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}, {""id"": ""UniProtKB:P12758"", ""source_sha256"": ""d9b0e2f3d5f330eed893f300120e66179abed88c2e5f870fe4fd75a30b11a153"", ""source_version"": ""2026_03; actual X-UniProt-Release header; retrieved 2026-10-11"", ""title"": ""Reviewed UniProtKB P12758"", ""url"": ""https://rest.uniprot.org/uniprotkb/P12758.json""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-037_33afb2a178c2	UniProtKB:P08331	pathwaymech:has_cofactor	CHEBI:60240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08331		"[{""reference_id"": ""UniProtKB:P08331"", ""source_assertion"": ""The reviewed CpdB entry annotates a divalent-metal cofactor by similarity; no particular physiological metal or binding stoichiometry is asserted."", ""source_locator"": ""comments[3] COFACTOR; ECO:0000250""}]"	"[{""id"": ""UniProtKB:P08331"", ""source_sha256"": ""0d8885316f9e124d953362c0b2050ee647cdcdfd946b468ce939b522cd461e55"", ""source_version"": ""2026_03; actual X-UniProt-Release header; retrieved 2026-10-11"", ""title"": ""Reviewed UniProtKB P08331"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08331.json""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-038_787ae60c04cc	UniProtKB:P0A6K6	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6K6		"[{""reference_id"": ""UniProtKB:P0A6K6"", ""source_assertion"": ""Mn2+ activates purified E. coli DeoB; Co2+ is an alternative activator. The two-ion stoichiometry is by similarity and is not asserted by this edge."", ""source_locator"": ""comments[3] COFACTOR; PMID4992818 evidence and note""}]"	"[{""id"": ""UniProtKB:P0A6K6"", ""source_sha256"": ""832643bbf42bfcb2ef2e5598e24ff7f18f224bde94291d56a8d5a61bed4b3d66"", ""source_version"": ""2026_03; actual X-UniProt-Release header; retrieved 2026-10-11"", ""title"": ""Reviewed UniProtKB P0A6K6"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6K6.json""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-039_d3120c8fa72c	UniProtKB:P0A6K6	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6K6		"[{""reference_id"": ""UniProtKB:P0A6K6"", ""source_assertion"": ""Co2+ and Mn2+ are alternative equally good activators in the cited purified-enzyme assay; they are not asserted to bind simultaneously."", ""source_locator"": ""comments[3] COFACTOR; PMID4992818 evidence and note""}]"	"[{""id"": ""UniProtKB:P0A6K6"", ""source_sha256"": ""832643bbf42bfcb2ef2e5598e24ff7f18f224bde94291d56a8d5a61bed4b3d66"", ""source_version"": ""2026_03; actual X-UniProt-Release header; retrieved 2026-10-11"", ""title"": ""Reviewed UniProtKB P0A6K6"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6K6.json""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-040_7045b340a923	UniProtKB:P0ABF6	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0ABF6		"[{""reference_id"": ""UniProtKB:P0ABF6"", ""source_assertion"": ""The reviewed Cdd entry assigns zinc as the bound cofactor with experimental structural citations; this does not imply activation by excess free zinc."", ""source_locator"": ""COFACTOR comment""}]"	"[{""id"": ""UniProtKB:P0ABF6"", ""source_sha256"": ""ecffd6fea9810f3756dfa4dd7c17be85954ab1f19b73ad98660394b2c20a0637"", ""source_version"": ""2026_03; actual X-UniProt-Release header; retrieved 2026-10-11"", ""title"": ""Reviewed UniProtKB P0ABF6"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABF6.json""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-041_0d1489d851b6	RHEA:27879	BFO:0000066	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08331		"[{""reference_id"": ""UniProtKB:P08331"", ""source_assertion"": ""CpdB is periplasmic; this localizes its two annotated uridine hydrolyses without assigning a cellular compartment to all copies of the chemical classes."", ""source_locator"": ""SUBCELLULAR LOCATION comment; PMID3005231""}]"	"[{""id"": ""UniProtKB:P08331"", ""source_sha256"": ""0d8885316f9e124d953362c0b2050ee647cdcdfd946b468ce939b522cd461e55"", ""source_version"": ""2026_03; actual X-UniProt-Release header; retrieved 2026-10-11"", ""title"": ""Reviewed UniProtKB P08331"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08331.json""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-042_5806f1f0518c	RHEA:27891	BFO:0000066	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08331		"[{""reference_id"": ""UniProtKB:P08331"", ""source_assertion"": ""CpdB is periplasmic; this localizes its two annotated uridine hydrolyses without assigning a cellular compartment to all copies of the chemical classes."", ""source_locator"": ""SUBCELLULAR LOCATION comment; PMID3005231""}]"	"[{""id"": ""UniProtKB:P08331"", ""source_sha256"": ""0d8885316f9e124d953362c0b2050ee647cdcdfd946b468ce939b522cd461e55"", ""source_version"": ""2026_03; actual X-UniProt-Release header; retrieved 2026-10-11"", ""title"": ""Reviewed UniProtKB P08331"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08331.json""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-043_5b430b5ac6df	UniProtKB:P0AFF4	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AFF4		"[{""reference_id"": ""UniProtKB:P0AFF4"", ""source_assertion"": ""NupG is a multipass cell-inner-membrane transporter with direct experimental evidence. The plasma membrane class describes the bacterial inner membrane."", ""source_locator"": ""SUBCELLULAR LOCATION comment""}]"	"[{""id"": ""UniProtKB:P0AFF4"", ""source_sha256"": ""9243c3ca2a5ecd5f1c1cb0bc6d5affc2561425a0ae9ee62f323f17925d3b2b27"", ""source_version"": ""2026_03; actual X-UniProt-Release header; retrieved 2026-10-11"", ""title"": ""Reviewed UniProtKB P0AFF4"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AFF4.json""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-044_6d4252097fc9	PathBank:SMP0002038/Compound/PW_C000202_Periplasmic_Space	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0042597|PathBank:SMP0002038		"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""The native physical object has an explicit cellularLocation pointing to this compartment."", ""source_locator"": ""bp:SmallMolecule[@rdf:ID=\""Compound/PW_C000202_Periplasmic_Space\""]/bp:cellularLocation; bp:CellularLocationVocabulary/bp:xref""}, {""reference_id"": ""GO:0042597"", ""source_assertion"": ""The native obsolete GO:0005620 cross-reference has explicit IAO:0100001 replacement GO:0042597, also listed as an alternative ID of the current term."", ""source_locator"": ""GO:0005620 IAO:0100001; GO:0042597 oio:hasAlternativeId and rdfs:label""}]"	"[{""id"": ""GO:0042597"", ""source_sha256"": ""018a7ef0a5bd1c0767abc3d71b413264a25be7579533daf5349f739cd9a122cd"", ""source_version"": ""Independent cached GO sqlite authority; inspected2026-10-11; SHA covers sqlite body"", ""title"": ""GO periplasmic space replacement authority"", ""url"": ""https://purl.obolibrary.org/obo/GO_0042597""}, {""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-045_66be6e8bea48	PathBank:SMP0002038/Compound/PW_C000202_Cytosol	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002038		"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""The native physical object has an explicit cellularLocation pointing to this compartment."", ""source_locator"": ""bp:SmallMolecule[@rdf:ID=\""Compound/PW_C000202_Cytosol\""]/bp:cellularLocation; bp:CellularLocationVocabulary/bp:xref""}]"	"[{""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-046_5855468cff2e	PathBank:SMP0002038/Compound/PW_C000061_Periplasmic_Space	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0042597|PathBank:SMP0002038		"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""The native physical object has an explicit cellularLocation pointing to this compartment."", ""source_locator"": ""bp:SmallMolecule[@rdf:ID=\""Compound/PW_C000061_Periplasmic_Space\""]/bp:cellularLocation; bp:CellularLocationVocabulary/bp:xref""}, {""reference_id"": ""GO:0042597"", ""source_assertion"": ""The native obsolete GO:0005620 cross-reference has explicit IAO:0100001 replacement GO:0042597, also listed as an alternative ID of the current term."", ""source_locator"": ""GO:0005620 IAO:0100001; GO:0042597 oio:hasAlternativeId and rdfs:label""}]"	"[{""id"": ""GO:0042597"", ""source_sha256"": ""018a7ef0a5bd1c0767abc3d71b413264a25be7579533daf5349f739cd9a122cd"", ""source_version"": ""Independent cached GO sqlite authority; inspected2026-10-11; SHA covers sqlite body"", ""title"": ""GO periplasmic space replacement authority"", ""url"": ""https://purl.obolibrary.org/obo/GO_0042597""}, {""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-047_82ff98c6bcd3	PathBank:SMP0002038/Compound/PW_C000061_Cytosol	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002038		"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""The native physical object has an explicit cellularLocation pointing to this compartment."", ""source_locator"": ""bp:SmallMolecule[@rdf:ID=\""Compound/PW_C000061_Cytosol\""]/bp:cellularLocation; bp:CellularLocationVocabulary/bp:xref""}]"	"[{""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-048_0858788cfe51	PathBank:SMP0002038/Compound/PW_C040034_Periplasmic_Space	RO:0001025	GO:0042597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	GO:0042597|PathBank:SMP0002038		"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""The native physical object has an explicit cellularLocation pointing to this compartment."", ""source_locator"": ""bp:SmallMolecule[@rdf:ID=\""Compound/PW_C040034_Periplasmic_Space\""]/bp:cellularLocation; bp:CellularLocationVocabulary/bp:xref""}, {""reference_id"": ""GO:0042597"", ""source_assertion"": ""The native obsolete GO:0005620 cross-reference has explicit IAO:0100001 replacement GO:0042597, also listed as an alternative ID of the current term."", ""source_locator"": ""GO:0005620 IAO:0100001; GO:0042597 oio:hasAlternativeId and rdfs:label""}]"	"[{""id"": ""GO:0042597"", ""source_sha256"": ""018a7ef0a5bd1c0767abc3d71b413264a25be7579533daf5349f739cd9a122cd"", ""source_version"": ""Independent cached GO sqlite authority; inspected2026-10-11; SHA covers sqlite body"", ""title"": ""GO periplasmic space replacement authority"", ""url"": ""https://purl.obolibrary.org/obo/GO_0042597""}, {""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-049_166f916bee26	PathBank:SMP0002038/Compound/PW_C040034_Cytosol	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002038		"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""The native physical object has an explicit cellularLocation pointing to this compartment."", ""source_locator"": ""bp:SmallMolecule[@rdf:ID=\""Compound/PW_C040034_Cytosol\""]/bp:cellularLocation; bp:CellularLocationVocabulary/bp:xref""}]"	"[{""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-050_de330048cb4b	RHEA:27879	RO:0002413	RHEA:27891	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002038	Inferred chemical dependency within the complete source route; alternative uptake and metabolic fates remain possible.	"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Curator inference: 3′-UMP product/substrate connect these native steps. BioPAX pathway membership is explicit; flux, exclusivity and obligatory use of NupG are not measured by the diagram."", ""source_locator"": ""bp:Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002038\""]/bp:pathwayComponent; referenced reaction/transport sides and compound entityReference""}]"	"[{""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-051_919d83bfb28a	RHEA:27891	RO:0002413	RHEA:29953	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002038	Inferred chemical dependency within the complete source route; alternative uptake and metabolic fates remain possible.	"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Curator inference: uridine formed in the periplasm and uridine import connect these native steps. BioPAX pathway membership is explicit; flux, exclusivity and obligatory use of NupG are not measured by the diagram."", ""source_locator"": ""bp:Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002038\""]/bp:pathwayComponent; referenced reaction/transport sides and compound entityReference""}]"	"[{""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-052_bed75d8e2a0b	RHEA:29953	RO:0002413	RHEA:24389	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002038	Inferred chemical dependency within the complete source route; alternative uptake and metabolic fates remain possible.	"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Curator inference: cytosolic uridine after import and uridine phosphorolysis connect these native steps. BioPAX pathway membership is explicit; flux, exclusivity and obligatory use of NupG are not measured by the diagram."", ""source_locator"": ""bp:Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002038\""]/bp:pathwayComponent; referenced reaction/transport sides and compound entityReference""}]"	"[{""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-053_1cbbf5dc1400	RHEA:29985	RO:0002413	RHEA:16070	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002038	Inferred chemical dependency within the complete source route; alternative uptake and metabolic fates remain possible.	"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Curator inference: cytosolic cytidine after import and cytidine deamination connect these native steps. BioPAX pathway membership is explicit; flux, exclusivity and obligatory use of NupG are not measured by the diagram."", ""source_locator"": ""bp:Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002038\""]/bp:pathwayComponent; referenced reaction/transport sides and compound entityReference""}]"	"[{""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-054_e7f4da104c49	RHEA:16070	RO:0002413	RHEA:24389	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002038	Inferred chemical dependency within the complete source route; alternative uptake and metabolic fates remain possible.	"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Curator inference: uridine product/substrate connect these native steps. BioPAX pathway membership is explicit; flux, exclusivity and obligatory use of NupG are not measured by the diagram."", ""source_locator"": ""bp:Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002038\""]/bp:pathwayComponent; referenced reaction/transport sides and compound entityReference""}]"	"[{""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}]"	""
pathwaymech:PathBank_SMP0002038_pyribo-edge-055_46f3fdffc85e	RHEA:24389	RO:0002413	RHEA:18794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PathBank:SMP0002038	Inferred chemical dependency within the complete source route; alternative uptake and metabolic fates remain possible.	"[{""reference_id"": ""PathBank:SMP0002038"", ""source_assertion"": ""Curator inference: alpha-D-ribose1-phosphate product/substrate connect these native steps. BioPAX pathway membership is explicit; flux, exclusivity and obligatory use of NupG are not measured by the diagram."", ""source_locator"": ""bp:Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002038\""]/bp:pathwayComponent; referenced reaction/transport sides and compound entityReference""}]"	"[{""id"": ""PathBank:SMP0002038"", ""source_sha256"": ""031e4e3cc4e762ff7c8dc9c39193dd1669585efe2d93cfb9cb9d84f1e25b4045"", ""source_version"": ""Primary BioPAX archive; exact PW002024.owl member retrieved 2026-10-10"", ""title"": ""PathBank Pyrimidine Ribonucleosides Degradation, native PW002024 BioPAX"", ""url"": ""https://pathbank.org/view/SMP0002038""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-001_2dae98b4def5	gomodel:YeastPathways_PYRUVDEHYD-PWY/6a4c244800000320	RO:0002233	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PYRUVDEHYD-PWY/6a4c244800000320 RO:0002233 gomodel:YeastPathways_PYRUVDEHYD-PWY/6a4c244800000322."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/0; endpoint types: /individuals/39/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-002_5637f86f75b5	gomodel:RXN0-1134	BFO:0000050	GO:0006086	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1134 BFO:0000050 gomodel:YeastPathways_PYRUVDEHYD-PWY/YeastPathways_PYRUVDEHYD-PWY."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/1; endpoint types: /individuals/13/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-003_a3157ec94afa	gomodel:YeastPathways_PYRUVDEHYD-PWY/6a4c244800000320	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PYRUVDEHYD-PWY/6a4c244800000320 RO:0002233 gomodel:YeastPathways_PYRUVDEHYD-PWY/6a4c244800000321."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/2; endpoint types: /individuals/39/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-004_10f361841cc2	gomodel:RXN0-1134	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1134 RO:0002234 gomodel:CHEBI_16526_RXN0-1134."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/3; endpoint types: /individuals/13/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-005_0e4558ed5611	gomodel:RXN0-1132	BFO:0000050	GO:0006086	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1132 BFO:0000050 gomodel:YeastPathways_PYRUVDEHYD-PWY/YeastPathways_PYRUVDEHYD-PWY."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/4; endpoint types: /individuals/11/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-006_36da75cf7cf7	gomodel:YeastPathways_PYRUVDEHYD-PWY/6a4c244800000320	RO:0002233	CHEBI:80218	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PYRUVDEHYD-PWY/6a4c244800000320 RO:0002233 gomodel:CHEBI_80218_RXN0-1132."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/5; endpoint types: /individuals/39/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-007_e05c4cbb8fd2	gomodel:RXN0-1134	RO:0002233	CHEBI:80218	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1134 RO:0002233 gomodel:CHEBI_80218_RXN0-1132."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/6; endpoint types: /individuals/13/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-009_2a80b866634e	gomodel:YeastPathways_PYRUVDEHYD-PWY/6a4c244800000320	BFO:0000050	GO:0006086	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PYRUVDEHYD-PWY/6a4c244800000320 BFO:0000050 gomodel:YeastPathways_PYRUVDEHYD-PWY/YeastPathways_PYRUVDEHYD-PWY."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/8; endpoint types: /individuals/39/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-010_fa9cb54f6309	gomodel:YeastPathways_PYRUVDEHYD-PWY/6a4c244800000320	RO:0002234	CHEBI:80404	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PYRUVDEHYD-PWY/6a4c244800000320 RO:0002234 gomodel:CHEBI_80404_RXN0-1134."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/9; endpoint types: /individuals/39/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-011_ecde49319917	gomodel:RXN0-1132	RO:0002233	CHEBI:80219	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1132 RO:0002233 gomodel:CHEBI_80219_RXN0-1133."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/10; endpoint types: /individuals/11/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-014_91e5ad8ae902	gomodel:RXN0-1133	BFO:0000050	GO:0006086	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1133 BFO:0000050 gomodel:YeastPathways_PYRUVDEHYD-PWY/YeastPathways_PYRUVDEHYD-PWY."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/13; endpoint types: /individuals/12/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-015_5c44e9f23882	gomodel:YeastPathways_PYRUVDEHYD-PWY/6a4c244800000320	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PYRUVDEHYD-PWY/6a4c244800000320 RO:0002234 gomodel:YeastPathways_PYRUVDEHYD-PWY/6a4c244800000323."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/14; endpoint types: /individuals/39/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-016_d48e15d88a4d	SGD:S000005015	pathwaymech:enables	gomodel:RXN0-1133	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1133 RO:0002333 gomodel:YNL071W-MONOMER_RXN0-1133_controller."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/15; endpoint types: /individuals/12/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-017_80f25de528e7	gomodel:RXN0-1134	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1134 RO:0002233 gomodel:CHEBI_15378_RXN0-1134."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/16; endpoint types: /individuals/13/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-018_2f95ceee73a5	gomodel:RXN0-1133	RO:0002234	CHEBI:57288	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1133 RO:0002234 gomodel:CHEBI_57288_RXN0-1133."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/17; endpoint types: /individuals/12/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-019_0e36f2e5de87	gomodel:RXN0-1132	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1132 RO:0002234 gomodel:CHEBI_15378_RXN0-1132."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/18; endpoint types: /individuals/11/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-020_78770f478278	gomodel:RXN0-1133	RO:0002233	CHEBI:80404	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1133 RO:0002233 gomodel:CHEBI_80404_RXN0-1134."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/19; endpoint types: /individuals/12/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-021_45c3be24c314	SGD:S000001876	pathwaymech:enables	gomodel:RXN0-1132	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1132 RO:0002333 gomodel:YFL018C-MONOMER_RXN0-1132_controller."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/20; endpoint types: /individuals/11/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-022_9870b47265a4	gomodel:RXN0-1132	RO:0002234	CHEBI:80218	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1132 RO:0002234 gomodel:CHEBI_80218_RXN0-1132."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/21; endpoint types: /individuals/11/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-023_7dacf6904cbe	gomodel:RXN0-1133	RO:0002234	CHEBI:80219	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1133 RO:0002234 gomodel:CHEBI_80219_RXN0-1133."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/22; endpoint types: /individuals/12/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-024_72420cc9c984	gomodel:RXN0-1132	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1132 RO:0002233 gomodel:CHEBI_57540_RXN0-1132."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/23; endpoint types: /individuals/11/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-025_6d063dddf0df	SGD:S000000425	pathwaymech:enables	gomodel:YeastPathways_PYRUVDEHYD-PWY/6a4c244800000320	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PYRUVDEHYD-PWY/6a4c244800000320 RO:0002333 gomodel:YeastPathways_PYRUVDEHYD-PWY/6a4c244800000324."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/24; endpoint types: /individuals/39/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-027_84caae744d7c	gomodel:RXN0-1134	RO:0002233	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1134 RO:0002233 gomodel:CHEBI_15361_RXN0-1134."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/26; endpoint types: /individuals/13/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-028_5c67d64174b3	gomodel:RXN0-1132	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1132 RO:0002234 gomodel:CHEBI_57945_RXN0-1132."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/27; endpoint types: /individuals/11/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-029_c87f98e23920	gomodel:RXN0-1134	RO:0002234	CHEBI:80404	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1134 RO:0002234 gomodel:CHEBI_80404_RXN0-1134."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/28; endpoint types: /individuals/13/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-030_1cdbcf5cb6a6	SGD:S000000980	pathwaymech:enables	gomodel:RXN0-1134	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1134 RO:0002333 gomodel:YeastPathways_PYRUVDEHYD-PWY/6690711d00000754."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/29; endpoint types: /individuals/13/type; /individuals/53/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_edge-031_5dafc1b6616f	gomodel:RXN0-1133	RO:0002233	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PYRUVDEHYD-PWY		"[{""reference_id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_assertion"": ""The model asserts gomodel:RXN0-1133 RO:0002233 gomodel:CHEBI_57287_RXN0-1133."", ""source_locator"": ""./YeastPathways_PYRUVDEHYD-PWY.json#/facts/30; endpoint types: /individuals/12/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PYRUVDEHYD-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PYRUVDEHYD-PWY.json"", ""title"": ""SGD GO-CAM pyruvate decarboxylation to acetyl CoA - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_location-efb0c89a0a87_b794eebb2452	SGD:S000005015	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P12695	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P12695"", ""source_assertion"": ""UniProtKB:P12695 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/350/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P12695"", ""source_assertion"": ""UniProtKB:P12695 has the exact SGD cross-reference SGD:S000005015."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/350/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P12695"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P12695 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_location-2dcce5c5fdd8_ab22d3dae330	SGD:S000001876	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09624	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P09624"", ""source_assertion"": ""UniProtKB:P09624 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/227/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P09624"", ""source_assertion"": ""UniProtKB:P09624 has the exact SGD cross-reference SGD:S000001876."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/227/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P09624"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P09624 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_location-f939a0a665be_4cc6f578dc59	SGD:S000000425	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32473	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P32473"", ""source_assertion"": ""UniProtKB:P32473 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3420/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32473"", ""source_assertion"": ""UniProtKB:P32473 has the exact SGD cross-reference SGD:S000000425."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3420/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32473"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32473 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_location-2142d6560bee_a97c6654cf9e	SGD:S000000980	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16387	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P16387"", ""source_assertion"": ""UniProtKB:P16387 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/437/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P16387"", ""source_assertion"": ""UniProtKB:P16387 has the exact SGD cross-reference SGD:S000000980."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/437/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P16387"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16387 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_cofactor-eae05efbb540_5dc2c98e10cc	SGD:S000005015	pathwaymech:has_cofactor	CHEBI:83088	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P12695	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The source describes a covalently attached cofactor moiety. Keep that bound-state qualification; no free cosubstrate consumption is inferred. UniProt evidence: not specified Binds 1 lipoyl cofactor covalently. UniProt note evidence: ECO:0000269 (PubMed:3050999)	"[{""reference_id"": ""UniProtKB:P12695"", ""source_assertion"": ""UniProtKB:P12695 annotates CHEBI:83088 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/350/comments/0/cofactors/0; /results/350/comments/0/note""}, {""reference_id"": ""UniProtKB:P12695"", ""source_assertion"": ""UniProtKB:P12695 has the exact SGD cross-reference SGD:S000005015."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/350/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P12695"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P12695 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_cofactor-4fb48c2e1250_17d9896f11fc	SGD:S000001876	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09624	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:9538259); ECO:0000269 (Reference:Ref.13) Binds 1 FAD per subunit. UniProt note evidence: ECO:0000269 (PubMed:9538259); ECO:0000269 (Reference:Ref.13)	"[{""reference_id"": ""UniProtKB:P09624"", ""source_assertion"": ""UniProtKB:P09624 annotates CHEBI:57692 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/227/comments/0/cofactors/0; /results/227/comments/0/note""}, {""reference_id"": ""UniProtKB:P09624"", ""source_assertion"": ""UniProtKB:P09624 has the exact SGD cross-reference SGD:S000001876."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/227/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P09624"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P09624 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_cofactor-c78d6b30ebb8_bc52a82574ef	SGD:S000000425	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32473	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P11177)	"[{""reference_id"": ""UniProtKB:P32473"", ""source_assertion"": ""UniProtKB:P32473 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3420/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P32473"", ""source_assertion"": ""UniProtKB:P32473 has the exact SGD cross-reference SGD:S000000425."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3420/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32473"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32473 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_cofactor-6ab5ad6c4e22_a3517674dabf	SGD:S000000980	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16387	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P08559)	"[{""reference_id"": ""UniProtKB:P16387"", ""source_assertion"": ""UniProtKB:P16387 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/437/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P16387"", ""source_assertion"": ""UniProtKB:P16387 has the exact SGD cross-reference SGD:S000000980."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/437/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P16387"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16387 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PYRUVDEHYD-PWY_cofactor-fee258b5d0fc_5678796a18af	SGD:S000000980	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16387	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P08559)	"[{""reference_id"": ""UniProtKB:P16387"", ""source_assertion"": ""UniProtKB:P16387 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/437/comments/0/cofactors/1""}, {""reference_id"": ""UniProtKB:P16387"", ""source_assertion"": ""UniProtKB:P16387 has the exact SGD cross-reference SGD:S000000980."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/437/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P16387"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16387 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-001_9b667b9f7cb9	gomodel:YeastPathways_PWY3O-440/6a46ef0600000890	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000890 BFO:0000066 gomodel:YeastPathways_PWY3O-440/6a46ef0600000899."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/0; endpoint types: /individuals/88/type; /individuals/95/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-002_03f37d88f1dd	gomodel:YeastPathways_PWY3O-440/6a46ef0600000822	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000824."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/1; endpoint types: /individuals/31/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-003_3a3ee46feb2e	gomodel:RXN-6161	RO:0002411	gomodel:YeastPathways_PWY3O-440/6a46ef0600000890	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN-6161 RO:0002411 gomodel:YeastPathways_PWY3O-440/6a46ef0600000890."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/2; endpoint types: /individuals/10/type; /individuals/88/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-004_708602dbd997	gomodel:YeastPathways_PWY3O-440/6a46ef0600000863	BFO:0000050	GO:0045151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000863 BFO:0000050 gomodel:YeastPathways_PWY3O-440/YeastPathways_PWY3O-440."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/3; endpoint types: /individuals/66/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-005_39b5bf0f4dd7	gomodel:RXN-6161	RO:0002411	gomodel:RXN0-2022	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN-6161 RO:0002411 gomodel:RXN0-2022."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/4; endpoint types: /individuals/10/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-006_b5779fe21fae	SGD:S000004034	pathwaymech:enables	gomodel:RXN-6161	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN-6161 RO:0002333 gomodel:YeastPathways_PWY3O-440/6690711d00000555."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/5; endpoint types: /individuals/10/type; /individuals/113/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-007_6c72526b54f3	gomodel:YeastPathways_PWY3O-440/6a46ef0600000876	RO:0002233	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000876 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000877."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/6; endpoint types: /individuals/77/type; /individuals/78/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-008_a32a002362ed	gomodel:YeastPathways_PWY3O-440/6a46ef0600000876	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000876 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000878."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/7; endpoint types: /individuals/77/type; /individuals/79/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-009_f8535a4ed1dc	gomodel:YeastPathways_PWY3O-440/6a46ef0600000890	RO:0002233	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000890 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000891."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/8; endpoint types: /individuals/88/type; /individuals/89/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-010_8973565054b3	gomodel:YeastPathways_PWY3O-440/6a46ef0600000822	RO:0002411	gomodel:YeastPathways_PWY3O-440/6a46ef0600000876	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 RO:0002411 gomodel:YeastPathways_PWY3O-440/6a46ef0600000876."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/9; endpoint types: /individuals/31/type; /individuals/77/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-011_e7a1b1aab6b3	gomodel:RXN0-2022	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN0-2022 BFO:0000066 gomodel:reaction_RXN0-2022_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/10; endpoint types: /individuals/11/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-012_3fdcecf3db32	gomodel:YeastPathways_PWY3O-440/6a46ef0600000890	RO:0002233	CHEBI:15343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000890 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000893."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/11; endpoint types: /individuals/88/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-013_d4af308c8483	gomodel:YeastPathways_PWY3O-440/6a46ef0600000822	RO:0002234	CHEBI:15343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 RO:0002234 gomodel:CHEBI_15343_RXN-6161."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/12; endpoint types: /individuals/31/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-014_d4bcc6d7e3f7	SGD:S000004034	pathwaymech:enables	gomodel:RXN3O-470	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN3O-470 RO:0002333 gomodel:YeastPathways_PWY3O-440/6690711d00000561."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/13; endpoint types: /individuals/12/type; /individuals/115/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-015_41e1543408bb	gomodel:RXN3O-470	BFO:0000050	GO:0045151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN3O-470 BFO:0000050 gomodel:YeastPathways_PWY3O-440/YeastPathways_PWY3O-440."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/14; endpoint types: /individuals/12/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-016_4268b0521508	gomodel:YeastPathways_PWY3O-440/6a46ef0600000876	RO:0002233	CHEBI:15343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000876 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000879."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/15; endpoint types: /individuals/77/type; /individuals/80/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-017_383294000997	gomodel:YeastPathways_PWY3O-440/6a46ef0600000833	RO:0002233	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000834."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/16; endpoint types: /individuals/40/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-018_c02ccd25c137	gomodel:RXN3O-470	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN3O-470 BFO:0000066 gomodel:reaction_RXN3O-470_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/17; endpoint types: /individuals/12/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-019_5ef90b105c75	gomodel:YeastPathways_PWY3O-440/6a46ef0600000833	RO:0002411	gomodel:YeastPathways_PWY3O-440/6a46ef0600000890	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 RO:0002411 gomodel:YeastPathways_PWY3O-440/6a46ef0600000890."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/18; endpoint types: /individuals/40/type; /individuals/88/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-020_6c526f542f69	gomodel:YeastPathways_PWY3O-440/6a46ef0600000863	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000863 BFO:0000066 gomodel:YeastPathways_PWY3O-440/6a46ef0600000868."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/19; endpoint types: /individuals/66/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-021_616c0ba49f17	gomodel:YeastPathways_PWY3O-440/6a46ef0600000833	RO:0002411	gomodel:YeastPathways_PWY3O-440/6a46ef0600000876	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 RO:0002411 gomodel:YeastPathways_PWY3O-440/6a46ef0600000876."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/20; endpoint types: /individuals/40/type; /individuals/77/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-022_012e14fd5c68	gomodel:YeastPathways_PWY3O-440/6a46ef0600000863	RO:0002233	CHEBI:15343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000863 RO:0002233 gomodel:CHEBI_15343_RXN-6161."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/21; endpoint types: /individuals/66/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-023_5dddb0b8cf33	gomodel:YeastPathways_PWY3O-440/6a46ef0600000890	BFO:0000050	GO:0045151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000890 BFO:0000050 gomodel:YeastPathways_PWY3O-440/YeastPathways_PWY3O-440."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/22; endpoint types: /individuals/88/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-024_9c495a0fb7b1	gomodel:YeastPathways_PWY3O-440/6a46ef0600000890	RO:0002234	CHEBI:15688	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000890 RO:0002234 gomodel:YeastPathways_PWY3O-440/6a46ef0600000895."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/23; endpoint types: /individuals/88/type; /individuals/93/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-025_1d6ede9cb559	gomodel:YeastPathways_PWY3O-440/6a46ef0600000833	RO:0002411	gomodel:RXN0-2022	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 RO:0002411 gomodel:RXN0-2022."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/24; endpoint types: /individuals/40/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-026_21fad260734f	gomodel:RXN0-2022	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN0-2022 RO:0002234 gomodel:CHEBI_16526_RXN0-2022."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/25; endpoint types: /individuals/11/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-027_4e063cfeec15	gomodel:YeastPathways_PWY3O-440/6a46ef0600000854	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000854 BFO:0000066 gomodel:YeastPathways_PWY3O-440/6a46ef0600000859."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/26; endpoint types: /individuals/59/type; /individuals/62/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-028_4cc88fbdf670	gomodel:YeastPathways_PWY3O-440/6a46ef0600000822	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 BFO:0000066 gomodel:YeastPathways_PWY3O-440/6a46ef0600000829."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/27; endpoint types: /individuals/31/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-029_8eb4355d7f1e	gomodel:YeastPathways_PWY3O-440/6a46ef0600000890	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000890 RO:0002234 gomodel:YeastPathways_PWY3O-440/6a46ef0600000894."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/28; endpoint types: /individuals/88/type; /individuals/92/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-030_0dbfd725d93b	gomodel:YeastPathways_PWY3O-440/6a46ef0600000876	BFO:0000050	GO:0045151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000876 BFO:0000050 gomodel:YeastPathways_PWY3O-440/YeastPathways_PWY3O-440."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/29; endpoint types: /individuals/77/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-031_0e0b76ea7b03	gomodel:RXN-6161	BFO:0000050	GO:0045151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN-6161 BFO:0000050 gomodel:YeastPathways_PWY3O-440/YeastPathways_PWY3O-440."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/30; endpoint types: /individuals/10/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-032_4b130e34e6df	gomodel:RXN-6161	RO:0002234	CHEBI:15343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN-6161 RO:0002234 gomodel:CHEBI_15343_RXN-6161."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/31; endpoint types: /individuals/10/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-033_63f274ddd841	gomodel:RXN-6161	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN-6161 RO:0002234 gomodel:CHEBI_16526_RXN-6161."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/32; endpoint types: /individuals/10/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-034_bb3320dfc8be	SGD:S000003319	pathwaymech:enables	gomodel:YeastPathways_PWY3O-440/6a46ef0600000890	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000890 RO:0002333 gomodel:YeastPathways_PWY3O-440/6a46ef0600000898."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/33; endpoint types: /individuals/88/type; /individuals/94/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-035_6baaa368a414	gomodel:YeastPathways_PWY3O-440/6a46ef0600000833	RO:0002234	CHEBI:15343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 RO:0002234 gomodel:CHEBI_15343_RXN-6161."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/34; endpoint types: /individuals/40/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-036_eea367cf34e4	gomodel:YeastPathways_PWY3O-440/6a46ef0600000876	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000876 RO:0002234 gomodel:YeastPathways_PWY3O-440/6a46ef0600000880."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/35; endpoint types: /individuals/77/type; /individuals/81/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-037_915c1acb973f	gomodel:RXN0-2022	RO:0002233	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN0-2022 RO:0002233 gomodel:CHEBI_15361_RXN0-2022."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/36; endpoint types: /individuals/11/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-038_52a8b1849cbb	gomodel:YeastPathways_PWY3O-440/6a46ef0600000876	RO:0002234	CHEBI:15688	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000876 RO:0002234 gomodel:YeastPathways_PWY3O-440/6a46ef0600000881."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/37; endpoint types: /individuals/77/type; /individuals/82/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-039_d9096562e860	gomodel:YeastPathways_PWY3O-440/6a46ef0600000822	RO:0002233	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000823."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/38; endpoint types: /individuals/31/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-040_915501f16038	gomodel:YeastPathways_PWY3O-440/6a46ef0600000822	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 RO:0002234 gomodel:YeastPathways_PWY3O-440/6a46ef0600000825."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/39; endpoint types: /individuals/31/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-041_e4aa7e9f561d	gomodel:YeastPathways_PWY3O-440/6a46ef0600000876	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000876 BFO:0000066 gomodel:YeastPathways_PWY3O-440/6a46ef0600000885."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/40; endpoint types: /individuals/77/type; /individuals/84/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-042_42c69af19b29	gomodel:YeastPathways_PWY3O-440/6a46ef0600000822	RO:0002411	gomodel:RXN0-2022	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 RO:0002411 gomodel:RXN0-2022."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/41; endpoint types: /individuals/31/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-043_35b9ac16d768	gomodel:RXN-6161	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN-6161 BFO:0000066 gomodel:reaction_RXN-6161_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/42; endpoint types: /individuals/10/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-044_45ac086c27ab	gomodel:YeastPathways_PWY3O-440/6a46ef0600000890	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000890 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000892."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/43; endpoint types: /individuals/88/type; /individuals/90/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-045_a1a88cc409fe	SGD:S000004124	pathwaymech:enables	gomodel:YeastPathways_PWY3O-440/6a46ef0600000876	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000876 RO:0002333 gomodel:YeastPathways_PWY3O-440/6a46ef0600000882."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/44; endpoint types: /individuals/77/type; /individuals/83/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-046_443adb91daa6	gomodel:YeastPathways_PWY3O-440/6a46ef0600000863	RO:0002234	CHEBI:15688	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000863 RO:0002234 gomodel:YeastPathways_PWY3O-440/6a46ef0600000864."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/45; endpoint types: /individuals/66/type; /individuals/67/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-047_5493c0572d10	gomodel:YeastPathways_PWY3O-440/6a46ef0600000833	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000835."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/46; endpoint types: /individuals/40/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-048_ef35e7eb2cbe	gomodel:RXN3O-470	RO:0002234	CHEBI:15688	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN3O-470 RO:0002234 gomodel:CHEBI_15688_RXN3O-470."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/47; endpoint types: /individuals/12/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-049_e5414fb13434	gomodel:YeastPathways_PWY3O-440/6a46ef0600000833	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 BFO:0000066 gomodel:YeastPathways_PWY3O-440/6a46ef0600000840."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/48; endpoint types: /individuals/40/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-050_4459e5ddc9e6	gomodel:YeastPathways_PWY3O-440/6a46ef0600000833	BFO:0000050	GO:0045151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 BFO:0000050 gomodel:YeastPathways_PWY3O-440/YeastPathways_PWY3O-440."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/49; endpoint types: /individuals/40/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-051_b1b974f47322	gomodel:YeastPathways_PWY3O-440/6a46ef0600000854	RO:0002234	CHEBI:15688	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000854 RO:0002234 gomodel:YeastPathways_PWY3O-440/6a46ef0600000855."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/50; endpoint types: /individuals/59/type; /individuals/60/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-052_419534a066f2	SGD:S000003319	pathwaymech:enables	gomodel:YeastPathways_PWY3O-440/6a46ef0600000833	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 RO:0002333 gomodel:YeastPathways_PWY3O-440/6a46ef0600000838."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/51; endpoint types: /individuals/40/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-053_e829e3236dc6	gomodel:YeastPathways_PWY3O-440/6a46ef0600000854	RO:0002233	CHEBI:15343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000854 RO:0002233 gomodel:CHEBI_15343_RXN-6161."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/52; endpoint types: /individuals/59/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-054_45eb1dfc2ea7	gomodel:YeastPathways_PWY3O-440/6a46ef0600000822	RO:0002411	gomodel:YeastPathways_PWY3O-440/6a46ef0600000890	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 RO:0002411 gomodel:YeastPathways_PWY3O-440/6a46ef0600000890."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/53; endpoint types: /individuals/31/type; /individuals/88/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-055_14538a0c3b2a	gomodel:RXN-6161	RO:0002411	gomodel:YeastPathways_PWY3O-440/6a46ef0600000876	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN-6161 RO:0002411 gomodel:YeastPathways_PWY3O-440/6a46ef0600000876."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/54; endpoint types: /individuals/10/type; /individuals/77/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-056_55409b7ff19b	SGD:S000003319	pathwaymech:enables	gomodel:YeastPathways_PWY3O-440/6a46ef0600000863	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000863 RO:0002333 gomodel:YeastPathways_PWY3O-440/6a46ef0600000867."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/55; endpoint types: /individuals/66/type; /individuals/68/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-057_b3cd0ab5ac74	gomodel:RXN-6161	RO:0002233	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN-6161 RO:0002233 gomodel:CHEBI_15361_RXN-6161."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/56; endpoint types: /individuals/10/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-058_576b21bcdda2	gomodel:RXN3O-470	RO:0002233	CHEBI:15343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN3O-470 RO:0002233 gomodel:CHEBI_15343_RXN-6161."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/57; endpoint types: /individuals/12/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-059_723a5df22cdb	SGD:S000004124	pathwaymech:enables	gomodel:YeastPathways_PWY3O-440/6a46ef0600000822	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 RO:0002333 gomodel:YeastPathways_PWY3O-440/6a46ef0600000826."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/58; endpoint types: /individuals/31/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-060_a244b3d529be	gomodel:YeastPathways_PWY3O-440/6a46ef0600000833	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 RO:0002234 gomodel:YeastPathways_PWY3O-440/6a46ef0600000836."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/59; endpoint types: /individuals/40/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-061_6e6eed490e68	gomodel:YeastPathways_PWY3O-440/6a46ef0600000822	BFO:0000050	GO:0045151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 BFO:0000050 gomodel:YeastPathways_PWY3O-440/YeastPathways_PWY3O-440."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/60; endpoint types: /individuals/31/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-062_808fd23cddf8	SGD:S000004034	pathwaymech:enables	gomodel:RXN0-2022	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN0-2022 RO:0002333 gomodel:YeastPathways_PWY3O-440/6690711d00000568."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/61; endpoint types: /individuals/11/type; /individuals/118/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-063_b5b4b04effc4	gomodel:YeastPathways_PWY3O-440/6a46ef0600000854	BFO:0000050	GO:0045151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000854 BFO:0000050 gomodel:YeastPathways_PWY3O-440/YeastPathways_PWY3O-440."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/62; endpoint types: /individuals/59/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-064_c2e7a31434be	gomodel:RXN0-2022	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN0-2022 RO:0002233 gomodel:CHEBI_15378_RXN0-2022."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/63; endpoint types: /individuals/11/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-065_825458a6ed7d	gomodel:RXN0-2022	BFO:0000050	GO:0045151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN0-2022 BFO:0000050 gomodel:YeastPathways_PWY3O-440/YeastPathways_PWY3O-440."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/64; endpoint types: /individuals/11/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-066_0949794756a6	gomodel:RXN0-2022	RO:0002233	CHEBI:15343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN0-2022 RO:0002233 gomodel:CHEBI_15343_RXN0-2022."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/65; endpoint types: /individuals/11/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-067_8eb059107918	gomodel:RXN-6161	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN-6161 RO:0002233 gomodel:CHEBI_15378_RXN-6161."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/66; endpoint types: /individuals/10/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-068_59df23337989	gomodel:RXN0-2022	RO:0002234	CHEBI:15688	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:RXN0-2022 RO:0002234 gomodel:CHEBI_15688_RXN0-2022."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/67; endpoint types: /individuals/11/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_edge-069_5d4c2228c714	SGD:S000004124	pathwaymech:enables	gomodel:YeastPathways_PWY3O-440/6a46ef0600000854	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-440		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000854 RO:0002333 gomodel:YeastPathways_PWY3O-440/6a46ef0600000857."", ""source_locator"": ""./YeastPathways_PWY3O-440.json#/facts/68; endpoint types: /individuals/59/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-440"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json"", ""title"": ""SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_location-e48c97df72e4_d00513900a51	SGD:S000004034	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06169	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P06169"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06169 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_location-d8ee7aa94925_4737bbbc82ac	SGD:S000004034	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06169	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P06169"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06169 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_location-ea1ab3242c76_af10c9fc93b6	SGD:S000003319	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26263	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/742/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/742/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P26263"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P26263 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_location-9ea10c14185b_e48051e10352	SGD:S000004124	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16467	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P16467"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16467 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_location-19eb0ec36ddd_dfaa9cd1f696	SGD:S000004124	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16467	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P16467"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16467 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_cofactor-81ce8a7e7be7_e54c7a2b3545	SGD:S000004034	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06169	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10651824) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000269 (PubMed:10651824)	"[{""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/comments/0/cofactors/0; /results/127/comments/0/note""}, {""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P06169"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06169 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_cofactor-5cf6d8babbe2_1d2d656745cb	SGD:S000004034	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06169	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10651824) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000269 (PubMed:10651824)	"[{""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/comments/1/cofactors/0; /results/127/comments/1/note""}, {""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P06169"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06169 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_cofactor-437eea628a9f_5d893a82dbe8	SGD:S000003319	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26263	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/comments/0/cofactors/0; /results/742/comments/0/note""}, {""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P26263"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P26263 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_cofactor-be7459c89012_e25407467914	SGD:S000003319	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26263	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/comments/1/cofactors/0; /results/742/comments/1/note""}, {""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P26263"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P26263 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_cofactor-93748e431c03_53f34222e6b2	SGD:S000004124	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16467	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/comments/0/cofactors/0; /results/439/comments/0/note""}, {""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P16467"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16467 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-440_cofactor-43ef6e61857d_7134273a9819	SGD:S000004124	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16467	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/comments/1/cofactors/0; /results/439/comments/1/note""}, {""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P16467"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16467 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-001_7c02bbf4f75e	CHEBI:57634	pathwaymech:consumes	RHEA:27628	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27626	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:27626"", ""source_assertion"": ""RHEA:27628 substrates contain CHEBI:57634 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/27628 rh:substrates; http://rdf.rhea-db.org/27626_R rh:contains1 http://rdf.rhea-db.org/Participant_27626_compound_5371; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27626"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:27626, selected riboneogenic direction RHEA:27628"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-002_46cbf5ae5ebc	CHEBI:59776	pathwaymech:consumes	RHEA:27628	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27626	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:27626"", ""source_assertion"": ""RHEA:27628 substrates contain CHEBI:59776 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/27628 rh:substrates; http://rdf.rhea-db.org/27626_R rh:contains1 http://rdf.rhea-db.org/Participant_27626_compound_6062; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27626"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:27626, selected riboneogenic direction RHEA:27628"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-003_d17e1c773474	RHEA:27628	pathwaymech:produces	CHEBI:16897	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27626	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:27626"", ""source_assertion"": ""RHEA:27628 products contain CHEBI:16897 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/27628 rh:products; http://rdf.rhea-db.org/27626_L rh:contains1 http://rdf.rhea-db.org/Participant_27626_compound_5282; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27626"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:27626, selected riboneogenic direction RHEA:27628"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-004_a8e71eed0434	RHEA:27628	pathwaymech:produces	CHEBI:57737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27626	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:27626"", ""source_assertion"": ""RHEA:27628 products contain CHEBI:57737 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/27628 rh:products; http://rdf.rhea-db.org/27626_L rh:contains1 http://rdf.rhea-db.org/Participant_27626_compound_1624; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:27626"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:27626, selected riboneogenic direction RHEA:27628"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-005_0185efa6e10a	CHEBI:16897	pathwaymech:consumes	RHEA:30168	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30167	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:30167"", ""source_assertion"": ""RHEA:30168 substrates contain CHEBI:16897 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30168 rh:substrates; http://rdf.rhea-db.org/30167_L rh:contains1 http://rdf.rhea-db.org/Participant_30167_compound_5282; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:30167"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:30167, selected riboneogenic direction RHEA:30168"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-006_a8ca67eb9ea8	CHEBI:57642	pathwaymech:consumes	RHEA:30168	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30167	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:30167"", ""source_assertion"": ""RHEA:30168 substrates contain CHEBI:57642 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30168 rh:substrates; http://rdf.rhea-db.org/30167_L rh:contains1 http://rdf.rhea-db.org/Participant_30167_compound_4255; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:30167"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:30167, selected riboneogenic direction RHEA:30168"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-007_38c118dfc216	RHEA:30168	pathwaymech:produces	CHEBI:58335	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30167	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:30167"", ""source_assertion"": ""RHEA:30168 products contain CHEBI:58335 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30168 rh:products; http://rdf.rhea-db.org/30167_R rh:contains1 http://rdf.rhea-db.org/Participant_30167_compound_2479; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:30167"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:30167, selected riboneogenic direction RHEA:30168"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-008_9a9578f08a8b	CHEBI:58335	pathwaymech:consumes	RHEA:17462	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17461	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:17461"", ""source_assertion"": ""RHEA:17462 substrates contain CHEBI:58335 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17462 rh:substrates; http://rdf.rhea-db.org/17461_L rh:contains1 http://rdf.rhea-db.org/Participant_17461_compound_2479; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17461"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:17461, selected riboneogenic direction RHEA:17462"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-009_94003a82d7f6	CHEBI:15377	pathwaymech:consumes	RHEA:17462	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17461	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:17461"", ""source_assertion"": ""RHEA:17462 substrates contain CHEBI:15377 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17462 rh:substrates; http://rdf.rhea-db.org/17461_L rh:contains1 http://rdf.rhea-db.org/Participant_17461_compound_1283; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17461"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:17461, selected riboneogenic direction RHEA:17462"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-010_4d727ba36e47	RHEA:17462	pathwaymech:produces	CHEBI:57483	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17461	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:17461"", ""source_assertion"": ""RHEA:17462 products contain CHEBI:57483 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17462 rh:products; http://rdf.rhea-db.org/17461_R rh:contains1 http://rdf.rhea-db.org/Participant_17461_compound_3830; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17461"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:17461, selected riboneogenic direction RHEA:17462"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-011_97ec138d3294	RHEA:17462	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17461	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:17461"", ""source_assertion"": ""RHEA:17462 products contain CHEBI:43474 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17462 rh:products; http://rdf.rhea-db.org/17461_R rh:contains1 http://rdf.rhea-db.org/Participant_17461_compound_5518; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17461"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:17461, selected riboneogenic direction RHEA:17462"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-012_24ce935ff9b0	CHEBI:57483	pathwaymech:consumes	RHEA:10509	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10508	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:10508"", ""source_assertion"": ""RHEA:10509 substrates contain CHEBI:57483 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10509 rh:substrates; http://rdf.rhea-db.org/10508_L rh:contains1 http://rdf.rhea-db.org/Participant_10508_compound_3830; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10508"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:10508, selected riboneogenic direction RHEA:10509"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-013_6d5bc1205278	CHEBI:59776	pathwaymech:consumes	RHEA:10509	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10508	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:10508"", ""source_assertion"": ""RHEA:10509 substrates contain CHEBI:59776 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10509 rh:substrates; http://rdf.rhea-db.org/10508_L rh:contains1 http://rdf.rhea-db.org/Participant_10508_compound_6062; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10508"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:10508, selected riboneogenic direction RHEA:10509"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-014_5effec216d93	RHEA:10509	pathwaymech:produces	CHEBI:58273	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10508	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:10508"", ""source_assertion"": ""RHEA:10509 products contain CHEBI:58273 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10509 rh:products; http://rdf.rhea-db.org/10508_R rh:contains1 http://rdf.rhea-db.org/Participant_10508_compound_6214; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10508"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:10508, selected riboneogenic direction RHEA:10509"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-015_8248b8f0b299	RHEA:10509	pathwaymech:produces	CHEBI:57737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10508	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:10508"", ""source_assertion"": ""RHEA:10509 products contain CHEBI:57737 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10509 rh:products; http://rdf.rhea-db.org/10508_R rh:contains1 http://rdf.rhea-db.org/Participant_10508_compound_1624; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10508"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:10508, selected riboneogenic direction RHEA:10509"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-016_8b2e0e69ceaa	CHEBI:57737	pathwaymech:consumes	RHEA:13679	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13677	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:13677"", ""source_assertion"": ""RHEA:13679 substrates contain CHEBI:57737 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/13679 rh:substrates; http://rdf.rhea-db.org/13677_R rh:contains1 http://rdf.rhea-db.org/Participant_13677_compound_1624; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13677"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:13677, selected riboneogenic direction RHEA:13679"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-017_0c12b6d609cb	RHEA:13679	pathwaymech:produces	CHEBI:58121	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:13677	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:13677"", ""source_assertion"": ""RHEA:13679 products contain CHEBI:58121 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/13679 rh:products; http://rdf.rhea-db.org/13677_L rh:contains1 http://rdf.rhea-db.org/Participant_13677_compound_1531; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:13677"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:13677, selected riboneogenic direction RHEA:13679"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-018_cf3a8106e019	CHEBI:58121	pathwaymech:consumes	RHEA:14659	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14657	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:14657"", ""source_assertion"": ""RHEA:14659 substrates contain CHEBI:58121 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/14659 rh:substrates; http://rdf.rhea-db.org/14657_R rh:contains1 http://rdf.rhea-db.org/Participant_14657_compound_1531; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14657"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:14657, selected riboneogenic direction RHEA:14659"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-019_fbc6d2da5270	RHEA:14659	pathwaymech:produces	CHEBI:58273	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:14657	Coefficient 1 in the selected riboneogenic direction; Rhea's formal charge and sugar representation are retained.	"[{""reference_id"": ""RHEA:14657"", ""source_assertion"": ""RHEA:14659 products contain CHEBI:58273 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/14659 rh:products; http://rdf.rhea-db.org/14657_L rh:contains1 http://rdf.rhea-db.org/Participant_14657_compound_6214; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:14657"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:14657, selected riboneogenic direction RHEA:14659"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-020_9740d7fd11d0	UniProtKB:P23254	pathwaymech:enables	RHEA:27628	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21663798|PathBank:SMP0002406|UniProtKB:P23254	Tkl1 functional contribution in its homodimeric enzyme context; this gene-product edge does not assert independent monomer activity. The primary route identifies Tkl1 as the main transketolase activity.	"[{""reference_id"": ""PMID:21663798"", ""source_assertion"": ""The pathway text assigns reactions 1 and 4 to transketolase TKL1/TKL2; Figure 6E places transketolase at both conversions."", ""source_locator"": ""PMC3163394 main text following equations (1)-(5); Figure 6E and accompanying Results""}, {""reference_id"": ""UniProtKB:P23254"", ""source_assertion"": ""SUBUNIT annotates a homodimer with experimental evidence ECO:0000269, including PMID:8176731."", ""source_locator"": ""comments[5].texts[0]; evidences""}, {""reference_id"": ""PathBank:SMP0002406"", ""source_assertion"": ""Native Reactions/7089 is controlled by Catalysis/7068 through complex4403, whose TKL1/TKL2 protein references identify P23254/P33315. This supports source role assignment, not the asserted mixed-complex composition."", ""source_locator"": ""PW002511.owl: Reactions/7089; Catalysis/7068; ProteinComplex/4403; ProteinReference/10736 and /10737""}]"	"[{""id"": ""PMID:21663798"", ""source_sha256"": ""831fcc40f7344b7e0a68164e48e7e131183ba8743d3e86d30a5f15c3d5ba0278"", ""source_version"": ""Primary full main article HTML; DOI10.1016/j.cell.2011.05.022; retrieved 2026-10-10; supplement URL returned non-PDF challenge and was not inspected"", ""title"": ""Riboneogenesis in yeast"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3163394/""}, {""id"": ""PathBank:SMP0002406"", ""source_sha256"": ""1f8af4af7f79034296739e1f0ef313974de23119528c4401c3f8b41f46594c2e"", ""source_version"": ""Public primary BioPAX archive; retrieved and member inspected 2026-10-10; digest is exact unmodified PW002511.owl member, not the archive"", ""title"": ""PathBank Riboneogenesis, native BioPAX member PW002511.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P23254"", ""source_sha256"": ""8b817c1f08114fe4e1ee8f522e9a539358821497a488f684868cb81eef34af6c"", ""source_version"": ""UniProt 2026_03; entry version 227; sequence version 4; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Transketolase 1 — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23254.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-021_abe08c538866	UniProtKB:P23254	pathwaymech:enables	RHEA:10509	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21663798|UniProtKB:P23254	Tkl1 functional contribution in its homodimeric enzyme context; this gene-product edge does not assert independent monomer activity. The primary route identifies Tkl1 as the main transketolase activity.	"[{""reference_id"": ""PMID:21663798"", ""source_assertion"": ""The pathway text assigns reactions 1 and 4 to transketolase TKL1/TKL2; Figure 6E places transketolase at both conversions."", ""source_locator"": ""PMC3163394 main text following equations (1)-(5); Figure 6E and accompanying Results""}, {""reference_id"": ""UniProtKB:P23254"", ""source_assertion"": ""SUBUNIT annotates a homodimer with experimental evidence ECO:0000269, including PMID:8176731."", ""source_locator"": ""comments[5].texts[0]; evidences""}, {""reference_id"": ""UniProtKB:P23254"", ""source_assertion"": ""CATALYTIC ACTIVITY assigns RHEA:10508 with ECO:0000269, including PMID:8521838."", ""source_locator"": ""comments[1].reaction; reactionCrossReferences; evidences""}]"	"[{""id"": ""PMID:21663798"", ""source_sha256"": ""831fcc40f7344b7e0a68164e48e7e131183ba8743d3e86d30a5f15c3d5ba0278"", ""source_version"": ""Primary full main article HTML; DOI10.1016/j.cell.2011.05.022; retrieved 2026-10-10; supplement URL returned non-PDF challenge and was not inspected"", ""title"": ""Riboneogenesis in yeast"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3163394/""}, {""id"": ""UniProtKB:P23254"", ""source_sha256"": ""8b817c1f08114fe4e1ee8f522e9a539358821497a488f684868cb81eef34af6c"", ""source_version"": ""UniProt 2026_03; entry version 227; sequence version 4; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Transketolase 1 — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23254.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-022_7abaea680a0d	UniProtKB:P33315	pathwaymech:enables	RHEA:27628	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21663798|PathBank:SMP0002406|UniProtKB:P33315	Tkl2 functional contribution in its homodimeric enzyme context; this gene-product edge does not assert independent monomer activity. Its specific reaction and assembly annotation is inferred by similarity, not separately purified Tkl2 evidence.	"[{""reference_id"": ""PMID:21663798"", ""source_assertion"": ""The pathway text assigns reactions 1 and 4 to transketolase TKL1/TKL2; Figure 6E places transketolase at both conversions."", ""source_locator"": ""PMC3163394 main text following equations (1)-(5); Figure 6E and accompanying Results""}, {""reference_id"": ""UniProtKB:P33315"", ""source_assertion"": ""SUBUNIT annotates a homodimer by similarity to P23254 (ECO:0000250)."", ""source_locator"": ""comments[5].texts[0]; evidences""}, {""reference_id"": ""PathBank:SMP0002406"", ""source_assertion"": ""Native Reactions/7089 is controlled by Catalysis/7068 through complex4403, whose TKL1/TKL2 protein references identify P23254/P33315. This supports source role assignment, not the asserted mixed-complex composition."", ""source_locator"": ""PW002511.owl: Reactions/7089; Catalysis/7068; ProteinComplex/4403; ProteinReference/10736 and /10737""}]"	"[{""id"": ""PMID:21663798"", ""source_sha256"": ""831fcc40f7344b7e0a68164e48e7e131183ba8743d3e86d30a5f15c3d5ba0278"", ""source_version"": ""Primary full main article HTML; DOI10.1016/j.cell.2011.05.022; retrieved 2026-10-10; supplement URL returned non-PDF challenge and was not inspected"", ""title"": ""Riboneogenesis in yeast"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3163394/""}, {""id"": ""PathBank:SMP0002406"", ""source_sha256"": ""1f8af4af7f79034296739e1f0ef313974de23119528c4401c3f8b41f46594c2e"", ""source_version"": ""Public primary BioPAX archive; retrieved and member inspected 2026-10-10; digest is exact unmodified PW002511.owl member, not the archive"", ""title"": ""PathBank Riboneogenesis, native BioPAX member PW002511.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""UniProtKB:P33315"", ""source_sha256"": ""8c01246058d0599e4f488cfeea68b88b20b58e3c194a2d8fe63efe1ddb8061ca"", ""source_version"": ""UniProt 2026_03; entry version 199; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Transketolase 2 — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33315.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-023_c81f597d49ef	UniProtKB:P33315	pathwaymech:enables	RHEA:10509	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21663798|UniProtKB:P33315	Tkl2 functional contribution in its homodimeric enzyme context; this gene-product edge does not assert independent monomer activity. Its specific reaction and assembly annotation is inferred by similarity, not separately purified Tkl2 evidence.	"[{""reference_id"": ""PMID:21663798"", ""source_assertion"": ""The pathway text assigns reactions 1 and 4 to transketolase TKL1/TKL2; Figure 6E places transketolase at both conversions."", ""source_locator"": ""PMC3163394 main text following equations (1)-(5); Figure 6E and accompanying Results""}, {""reference_id"": ""UniProtKB:P33315"", ""source_assertion"": ""SUBUNIT annotates a homodimer by similarity to P23254 (ECO:0000250)."", ""source_locator"": ""comments[5].texts[0]; evidences""}, {""reference_id"": ""UniProtKB:P33315"", ""source_assertion"": ""CATALYTIC ACTIVITY assigns RHEA:10508 by similarity to P23254, ECO:0000250."", ""source_locator"": ""comments[1].reaction; reactionCrossReferences; evidences""}]"	"[{""id"": ""PMID:21663798"", ""source_sha256"": ""831fcc40f7344b7e0a68164e48e7e131183ba8743d3e86d30a5f15c3d5ba0278"", ""source_version"": ""Primary full main article HTML; DOI10.1016/j.cell.2011.05.022; retrieved 2026-10-10; supplement URL returned non-PDF challenge and was not inspected"", ""title"": ""Riboneogenesis in yeast"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3163394/""}, {""id"": ""UniProtKB:P33315"", ""source_sha256"": ""8c01246058d0599e4f488cfeea68b88b20b58e3c194a2d8fe63efe1ddb8061ca"", ""source_version"": ""UniProt 2026_03; entry version 199; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Transketolase 2 — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33315.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-024_815720c17c74	UniProtKB:P14540	pathwaymech:enables	RHEA:30168	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21663798|UniProtKB:P14540	Fba1 enables aldol condensation of erythrose 4-phosphate with DHAP. Reduced FBA1 expression slows SBP labeling; UniProt annotates a homodimer without an inline evidence code. No isolated-monomer sufficiency is claimed.	"[{""quote"": ""labeling of SBP and OBP was markedly slowed"", ""reference_id"": ""PMID:21663798"", ""source_locator"": ""PMC3163394 Results, Sedoheptulose 1,7-bisphosphate is synthesized in vivo by fructose bisphosphate aldolase; Figure 4B""}, {""reference_id"": ""PMID:21663798"", ""source_assertion"": ""FBA1-DAmP reduced aldolase expression; precursor labeling was unchanged while SBP labeling slowed. Equation (2) and Figure 6E identify DHAP plus erythrose 4-phosphate as the route substrates."", ""source_locator"": ""PMC3163394 Results, aldolase isotope-labeling experiments; equation (2); Figures 4 and 6E""}, {""reference_id"": ""UniProtKB:P14540"", ""source_assertion"": ""The reviewed FBA1/YKL060C gene product is fructose-bisphosphate aldolase; SUBUNIT states Homodimer. Its catalytic comment describes FBP cleavage, not the distinct SBP reaction."", ""source_locator"": ""primaryAccession; genes; proteinDescription; comments[1,4]""}]"	"[{""id"": ""PMID:21663798"", ""source_sha256"": ""831fcc40f7344b7e0a68164e48e7e131183ba8743d3e86d30a5f15c3d5ba0278"", ""source_version"": ""Primary full main article HTML; DOI10.1016/j.cell.2011.05.022; retrieved 2026-10-10; supplement URL returned non-PDF challenge and was not inspected"", ""title"": ""Riboneogenesis in yeast"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3163394/""}, {""id"": ""UniProtKB:P14540"", ""source_sha256"": ""698ae373a94fdc9d837183616fbd7abb151c52e9ba53fa1b75f874cf6c83255e"", ""source_version"": ""UniProt 2026_03; entry version 224; sequence version 3; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Fructose-bisphosphate aldolase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P14540.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-025_91c92d11af07	UniProtKB:P36136	pathwaymech:enables	RHEA:17462	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21663798|UniProtKB:P36136	Shb17 hydrolysis is the committed step. The gene-product edge retains the homodimer context; the SBP-bound H13A structure contains two subunits. The possible Mg2+ density is not a demonstrated requirement and creates no cofactor edge.	"[{""reference_id"": ""UniProtKB:P36136"", ""source_assertion"": ""CATALYTIC ACTIVITY assigns RHEA:17461 and SUBUNIT a homodimer, with ECO:0000269 citing PMID:21663798 and PMID:20427268."", ""source_locator"": ""comments[1].reaction; comments[3].texts[0]; evidences""}, {""quote"": ""The structure revealed a protein dimer"", ""reference_id"": ""PMID:21663798"", ""source_locator"": ""PMC3163394 Results, Structure of Shb17-SBP complex, first paragraph""}, {""reference_id"": ""PMID:21663798"", ""source_assertion"": ""Purified Shb17 consumed SBP and produced S7P. Its H13A-SBP structure has possible Mg2+ density; the authors discuss optional phosphate coordination in a metal-independent enzyme, not an established Mg requirement."", ""source_locator"": ""PMC3163394 Results, Shb17 is a selective sedoheptulose and octulose bisphosphatase; Structure of Shb17-SBP complex; Figure 3""}]"	"[{""id"": ""PMID:21663798"", ""source_sha256"": ""831fcc40f7344b7e0a68164e48e7e131183ba8743d3e86d30a5f15c3d5ba0278"", ""source_version"": ""Primary full main article HTML; DOI10.1016/j.cell.2011.05.022; retrieved 2026-10-10; supplement URL returned non-PDF challenge and was not inspected"", ""title"": ""Riboneogenesis in yeast"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3163394/""}, {""id"": ""UniProtKB:P36136"", ""source_sha256"": ""18e7a733e01ce849a7abd22b93bdf96109baa5e14da63051d42b1a4211be01f1"", ""source_version"": ""UniProt 2026_03; entry version 163; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Sedoheptulose 1,7-bisphosphatase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P36136.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-026_e95d8e2e50c2	UniProtKB:P46969	pathwaymech:enables	RHEA:13679	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21663798|PMID:8929392|UniProtKB:P46969	Rpe1 supports xylulose-5-phosphate conversion to ribulose-5-phosphate in this route. Gene-deletion enzyme assays provide direct functional support; the current UniProt catalytic and metal annotations separately retain similarity evidence.	"[{""reference_id"": ""UniProtKB:P46969"", ""source_assertion"": ""CATALYTIC ACTIVITY assigns RHEA:13677 with ECO:0000250 to human Q96AT9; this is database similarity evidence."", ""source_locator"": ""comments[1].reaction; reactionCrossReferences; evidences""}, {""quote"": ""Deletion mutants of RPE1 show no enzyme activity"", ""reference_id"": ""PMID:8929392"", ""source_locator"": ""Europe PMC core result[id=\""8929392\""].abstractText""}, {""reference_id"": ""PMID:21663798"", ""source_assertion"": ""Figure 6E and the following text assign conversion of xylulose 5-phosphate to ribulose 5-phosphate to Rpe1."", ""source_locator"": ""PMC3163394 Figure 6E and Results, Shb17 oscillates with ribosomal transcripts in the yeast metabolic cycle""}]"	"[{""id"": ""PMID:21663798"", ""source_sha256"": ""831fcc40f7344b7e0a68164e48e7e131183ba8743d3e86d30a5f15c3d5ba0278"", ""source_version"": ""Primary full main article HTML; DOI10.1016/j.cell.2011.05.022; retrieved 2026-10-10; supplement URL returned non-PDF challenge and was not inspected"", ""title"": ""Riboneogenesis in yeast"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3163394/""}, {""id"": ""PMID:8929392"", ""source_sha256"": ""09f27448fa755c6e8d9f2b224c172f2925568ab558e3f5d907dfe7578a6d1e28"", ""source_version"": ""Primary abstract in Europe PMC core; retrieved 2026-10-10; full original article not inspected; exact JSON response digest"", ""title"": ""Cloning and characterization of the first two genes of the non-oxidative part of the Saccharomyces cerevisiae pentose-phosphate pathway."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8929392%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P46969"", ""source_sha256"": ""fed3162d8c9c807befb78170e6b1c9fe77413a8fb9e22cb58515d992f7d6fb76"", ""source_version"": ""UniProt 2026_03; entry version 177; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Ribulose-phosphate 3-epimerase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46969.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-027_9713f74e8eee	UniProtKB:Q12189	pathwaymech:enables	RHEA:14659	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21663798|PMID:8929392|UniProtKB:Q12189	Rki1 completes ribose-5-phosphate formation. Gene-dosage rescue supports the functional product; no oligomer stoichiometry is inferred from a missing SUBUNIT comment.	"[{""reference_id"": ""UniProtKB:Q12189"", ""source_assertion"": ""The RKI1 catalytic comment assigns RHEA:14657 with ECO:0000305 citing PMID:8929392, a curator-inference annotation."", ""source_locator"": ""genes; comments[0].reaction; reactionCrossReferences; evidences""}, {""quote"": ""restored viability and specific D-ribose-5-phosphate ketol-isomerase activity"", ""reference_id"": ""PMID:8929392"", ""source_locator"": ""Europe PMC core result[id=\""8929392\""].abstractText""}, {""reference_id"": ""PMID:21663798"", ""source_assertion"": ""Figure 6E and the following text assign conversion of ribulose 5-phosphate to ribose 5-phosphate to Rki1."", ""source_locator"": ""PMC3163394 Figure 6E and Results, Shb17 oscillates with ribosomal transcripts in the yeast metabolic cycle""}]"	"[{""id"": ""PMID:21663798"", ""source_sha256"": ""831fcc40f7344b7e0a68164e48e7e131183ba8743d3e86d30a5f15c3d5ba0278"", ""source_version"": ""Primary full main article HTML; DOI10.1016/j.cell.2011.05.022; retrieved 2026-10-10; supplement URL returned non-PDF challenge and was not inspected"", ""title"": ""Riboneogenesis in yeast"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3163394/""}, {""id"": ""PMID:8929392"", ""source_sha256"": ""09f27448fa755c6e8d9f2b224c172f2925568ab558e3f5d907dfe7578a6d1e28"", ""source_version"": ""Primary abstract in Europe PMC core; retrieved 2026-10-10; full original article not inspected; exact JSON response digest"", ""title"": ""Cloning and characterization of the first two genes of the non-oxidative part of the Saccharomyces cerevisiae pentose-phosphate pathway."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8929392%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:Q12189"", ""source_sha256"": ""ffac01f058a6f99ae38eb095491fbf4a1d9a344471c7f45210fc6ce18e51351e"", ""source_version"": ""UniProt 2026_03; entry version 196; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Ribose-5-phosphate isomerase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q12189.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-028_a9fd9dfa8586	RHEA:27628	BFO:0000050	PathBank:SMP0002406	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21663798|PathBank:SMP0002406|RHEA:27626	Manual correspondence of the native reaction, primary route and exact Rhea chemistry. PathBank supplies no Rhea cross-reference; protonation/tautomer distinctions are not exact-identity mappings. The native step is reversible; the graph selects the riboneogenic flux.	"[{""reference_id"": ""PathBank:SMP0002406"", ""source_assertion"": ""The native pathway explicitly includes Reactions/7089; conversionDirection is REVERSIBLE."", ""source_locator"": ""PW002511.owl: Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002406\""]/pathwayComponent; Reactions/7089/conversionDirection; left; right""}, {""reference_id"": ""RHEA:27626"", ""source_assertion"": ""RHEA:27626 lists RHEA:27628 as a directional reaction; its substrates and products define the selected orientation."", ""source_locator"": ""http://rdf.rhea-db.org/27626 rh:directionalReaction http://rdf.rhea-db.org/27628; http://rdf.rhea-db.org/27628 rh:substrates; rh:products""}, {""reference_id"": ""PMID:21663798"", ""source_assertion"": ""Equations (1)-(5) and Figure 6E define the aldolase/Shb17 route, with the final pentose conversion resolved into Rpe1 and Rki1 reactions."", ""source_locator"": ""PMC3163394 equations (1)-(5); Figure 6E and accompanying Results""}]"	"[{""id"": ""PMID:21663798"", ""source_sha256"": ""831fcc40f7344b7e0a68164e48e7e131183ba8743d3e86d30a5f15c3d5ba0278"", ""source_version"": ""Primary full main article HTML; DOI10.1016/j.cell.2011.05.022; retrieved 2026-10-10; supplement URL returned non-PDF challenge and was not inspected"", ""title"": ""Riboneogenesis in yeast"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3163394/""}, {""id"": ""PathBank:SMP0002406"", ""source_sha256"": ""1f8af4af7f79034296739e1f0ef313974de23119528c4401c3f8b41f46594c2e"", ""source_version"": ""Public primary BioPAX archive; retrieved and member inspected 2026-10-10; digest is exact unmodified PW002511.owl member, not the archive"", ""title"": ""PathBank Riboneogenesis, native BioPAX member PW002511.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:27626"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:27626, selected riboneogenic direction RHEA:27628"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-029_6157d708e8d3	RHEA:30168	BFO:0000050	PathBank:SMP0002406	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21663798|PathBank:SMP0002406|RHEA:30167	Manual correspondence of the native reaction, primary route and exact Rhea chemistry. PathBank supplies no Rhea cross-reference; protonation/tautomer distinctions are not exact-identity mappings. The native step is reversible; the graph selects the riboneogenic flux.	"[{""reference_id"": ""PathBank:SMP0002406"", ""source_assertion"": ""The native pathway explicitly includes Reactions/7090; conversionDirection is REVERSIBLE."", ""source_locator"": ""PW002511.owl: Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002406\""]/pathwayComponent; Reactions/7090/conversionDirection; left; right""}, {""reference_id"": ""RHEA:30167"", ""source_assertion"": ""RHEA:30167 lists RHEA:30168 as a directional reaction; its substrates and products define the selected orientation."", ""source_locator"": ""http://rdf.rhea-db.org/30167 rh:directionalReaction http://rdf.rhea-db.org/30168; http://rdf.rhea-db.org/30168 rh:substrates; rh:products""}, {""reference_id"": ""PMID:21663798"", ""source_assertion"": ""Equations (1)-(5) and Figure 6E define the aldolase/Shb17 route, with the final pentose conversion resolved into Rpe1 and Rki1 reactions."", ""source_locator"": ""PMC3163394 equations (1)-(5); Figure 6E and accompanying Results""}]"	"[{""id"": ""PMID:21663798"", ""source_sha256"": ""831fcc40f7344b7e0a68164e48e7e131183ba8743d3e86d30a5f15c3d5ba0278"", ""source_version"": ""Primary full main article HTML; DOI10.1016/j.cell.2011.05.022; retrieved 2026-10-10; supplement URL returned non-PDF challenge and was not inspected"", ""title"": ""Riboneogenesis in yeast"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3163394/""}, {""id"": ""PathBank:SMP0002406"", ""source_sha256"": ""1f8af4af7f79034296739e1f0ef313974de23119528c4401c3f8b41f46594c2e"", ""source_version"": ""Public primary BioPAX archive; retrieved and member inspected 2026-10-10; digest is exact unmodified PW002511.owl member, not the archive"", ""title"": ""PathBank Riboneogenesis, native BioPAX member PW002511.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:30167"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:30167, selected riboneogenic direction RHEA:30168"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-030_f1f887ef1773	RHEA:17462	BFO:0000050	PathBank:SMP0002406	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21663798|PathBank:SMP0002406|RHEA:17461	Manual correspondence of the native reaction, primary route and exact Rhea chemistry. PathBank supplies no Rhea cross-reference; protonation/tautomer distinctions are not exact-identity mappings. Native hydrolysis is left-to-right.	"[{""reference_id"": ""PathBank:SMP0002406"", ""source_assertion"": ""The native pathway explicitly includes Reactions/7091; conversionDirection is LEFT_TO_RIGHT."", ""source_locator"": ""PW002511.owl: Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002406\""]/pathwayComponent; Reactions/7091/conversionDirection; left; right""}, {""reference_id"": ""RHEA:17461"", ""source_assertion"": ""RHEA:17461 lists RHEA:17462 as a directional reaction; its substrates and products define the selected orientation."", ""source_locator"": ""http://rdf.rhea-db.org/17461 rh:directionalReaction http://rdf.rhea-db.org/17462; http://rdf.rhea-db.org/17462 rh:substrates; rh:products""}, {""reference_id"": ""PMID:21663798"", ""source_assertion"": ""Equations (1)-(5) and Figure 6E define the aldolase/Shb17 route, with the final pentose conversion resolved into Rpe1 and Rki1 reactions."", ""source_locator"": ""PMC3163394 equations (1)-(5); Figure 6E and accompanying Results""}]"	"[{""id"": ""PMID:21663798"", ""source_sha256"": ""831fcc40f7344b7e0a68164e48e7e131183ba8743d3e86d30a5f15c3d5ba0278"", ""source_version"": ""Primary full main article HTML; DOI10.1016/j.cell.2011.05.022; retrieved 2026-10-10; supplement URL returned non-PDF challenge and was not inspected"", ""title"": ""Riboneogenesis in yeast"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3163394/""}, {""id"": ""PathBank:SMP0002406"", ""source_sha256"": ""1f8af4af7f79034296739e1f0ef313974de23119528c4401c3f8b41f46594c2e"", ""source_version"": ""Public primary BioPAX archive; retrieved and member inspected 2026-10-10; digest is exact unmodified PW002511.owl member, not the archive"", ""title"": ""PathBank Riboneogenesis, native BioPAX member PW002511.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:17461"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:17461, selected riboneogenic direction RHEA:17462"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-031_3f14d6826db5	RHEA:10509	BFO:0000050	PathBank:SMP0002406	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21663798|PathBank:SMP0002406|RHEA:10508	Manual correspondence of the native reaction, primary route and exact Rhea chemistry. PathBank supplies no Rhea cross-reference; protonation/tautomer distinctions are not exact-identity mappings. The native step is reversible; the graph selects the riboneogenic flux.	"[{""reference_id"": ""PathBank:SMP0002406"", ""source_assertion"": ""The native pathway explicitly includes Reactions/7092; conversionDirection is REVERSIBLE."", ""source_locator"": ""PW002511.owl: Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002406\""]/pathwayComponent; Reactions/7092/conversionDirection; left; right""}, {""reference_id"": ""RHEA:10508"", ""source_assertion"": ""RHEA:10508 lists RHEA:10509 as a directional reaction; its substrates and products define the selected orientation."", ""source_locator"": ""http://rdf.rhea-db.org/10508 rh:directionalReaction http://rdf.rhea-db.org/10509; http://rdf.rhea-db.org/10509 rh:substrates; rh:products""}, {""reference_id"": ""PMID:21663798"", ""source_assertion"": ""Equations (1)-(5) and Figure 6E define the aldolase/Shb17 route, with the final pentose conversion resolved into Rpe1 and Rki1 reactions."", ""source_locator"": ""PMC3163394 equations (1)-(5); Figure 6E and accompanying Results""}]"	"[{""id"": ""PMID:21663798"", ""source_sha256"": ""831fcc40f7344b7e0a68164e48e7e131183ba8743d3e86d30a5f15c3d5ba0278"", ""source_version"": ""Primary full main article HTML; DOI10.1016/j.cell.2011.05.022; retrieved 2026-10-10; supplement URL returned non-PDF challenge and was not inspected"", ""title"": ""Riboneogenesis in yeast"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3163394/""}, {""id"": ""PathBank:SMP0002406"", ""source_sha256"": ""1f8af4af7f79034296739e1f0ef313974de23119528c4401c3f8b41f46594c2e"", ""source_version"": ""Public primary BioPAX archive; retrieved and member inspected 2026-10-10; digest is exact unmodified PW002511.owl member, not the archive"", ""title"": ""PathBank Riboneogenesis, native BioPAX member PW002511.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:10508"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:10508, selected riboneogenic direction RHEA:10509"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-032_498d6fa1a7da	RHEA:13679	BFO:0000050	PathBank:SMP0002406	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21663798|PathBank:SMP0002406|RHEA:13677	Manual correspondence of the native reaction, primary route and exact Rhea chemistry. PathBank supplies no Rhea cross-reference; protonation/tautomer distinctions are not exact-identity mappings. The native step is reversible; the graph selects the riboneogenic flux.	"[{""reference_id"": ""PathBank:SMP0002406"", ""source_assertion"": ""The native pathway explicitly includes Reactions/7094; conversionDirection is REVERSIBLE."", ""source_locator"": ""PW002511.owl: Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002406\""]/pathwayComponent; Reactions/7094/conversionDirection; left; right""}, {""reference_id"": ""RHEA:13677"", ""source_assertion"": ""RHEA:13677 lists RHEA:13679 as a directional reaction; its substrates and products define the selected orientation."", ""source_locator"": ""http://rdf.rhea-db.org/13677 rh:directionalReaction http://rdf.rhea-db.org/13679; http://rdf.rhea-db.org/13679 rh:substrates; rh:products""}, {""reference_id"": ""PMID:21663798"", ""source_assertion"": ""Equations (1)-(5) and Figure 6E define the aldolase/Shb17 route, with the final pentose conversion resolved into Rpe1 and Rki1 reactions."", ""source_locator"": ""PMC3163394 equations (1)-(5); Figure 6E and accompanying Results""}]"	"[{""id"": ""PMID:21663798"", ""source_sha256"": ""831fcc40f7344b7e0a68164e48e7e131183ba8743d3e86d30a5f15c3d5ba0278"", ""source_version"": ""Primary full main article HTML; DOI10.1016/j.cell.2011.05.022; retrieved 2026-10-10; supplement URL returned non-PDF challenge and was not inspected"", ""title"": ""Riboneogenesis in yeast"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3163394/""}, {""id"": ""PathBank:SMP0002406"", ""source_sha256"": ""1f8af4af7f79034296739e1f0ef313974de23119528c4401c3f8b41f46594c2e"", ""source_version"": ""Public primary BioPAX archive; retrieved and member inspected 2026-10-10; digest is exact unmodified PW002511.owl member, not the archive"", ""title"": ""PathBank Riboneogenesis, native BioPAX member PW002511.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:13677"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:13677, selected riboneogenic direction RHEA:13679"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-033_401578fea09a	RHEA:14659	BFO:0000050	PathBank:SMP0002406	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:21663798|PathBank:SMP0002406|RHEA:14657	Manual correspondence of the native reaction, primary route and exact Rhea chemistry. PathBank supplies no Rhea cross-reference; protonation/tautomer distinctions are not exact-identity mappings. The native step is reversible; the graph selects the riboneogenic flux.	"[{""reference_id"": ""PathBank:SMP0002406"", ""source_assertion"": ""The native pathway explicitly includes Reactions/7093; conversionDirection is REVERSIBLE."", ""source_locator"": ""PW002511.owl: Pathway[@rdf:about=\""http://identifiers.org/smpdb/SMP0002406\""]/pathwayComponent; Reactions/7093/conversionDirection; left; right""}, {""reference_id"": ""RHEA:14657"", ""source_assertion"": ""RHEA:14657 lists RHEA:14659 as a directional reaction; its substrates and products define the selected orientation."", ""source_locator"": ""http://rdf.rhea-db.org/14657 rh:directionalReaction http://rdf.rhea-db.org/14659; http://rdf.rhea-db.org/14659 rh:substrates; rh:products""}, {""reference_id"": ""PMID:21663798"", ""source_assertion"": ""Equations (1)-(5) and Figure 6E define the aldolase/Shb17 route, with the final pentose conversion resolved into Rpe1 and Rki1 reactions."", ""source_locator"": ""PMC3163394 equations (1)-(5); Figure 6E and accompanying Results""}]"	"[{""id"": ""PMID:21663798"", ""source_sha256"": ""831fcc40f7344b7e0a68164e48e7e131183ba8743d3e86d30a5f15c3d5ba0278"", ""source_version"": ""Primary full main article HTML; DOI10.1016/j.cell.2011.05.022; retrieved 2026-10-10; supplement URL returned non-PDF challenge and was not inspected"", ""title"": ""Riboneogenesis in yeast"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3163394/""}, {""id"": ""PathBank:SMP0002406"", ""source_sha256"": ""1f8af4af7f79034296739e1f0ef313974de23119528c4401c3f8b41f46594c2e"", ""source_version"": ""Public primary BioPAX archive; retrieved and member inspected 2026-10-10; digest is exact unmodified PW002511.owl member, not the archive"", ""title"": ""PathBank Riboneogenesis, native BioPAX member PW002511.owl"", ""url"": ""https://pathbank.org/downloads/pathbank_primary_biopax.zip""}, {""id"": ""RHEA:14657"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:14657, selected riboneogenic direction RHEA:14659"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-034_aee7786f66b0	UniProtKB:P23254	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23254	Reviewed protein cofactor annotation in its functional enzyme context. Binds 1 Mg(2+) ion per subunit (PubMed:18186462). Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+) (PubMed:18186462). These metals are alternatives, not simultaneous requirements.	"[{""reference_id"": ""UniProtKB:P23254"", ""source_assertion"": ""COFACTOR identifies CHEBI:18420 (Mg(2+)) with evidence ECO:0000269."", ""source_locator"": ""comments[2].cofactors[0]; cofactorCrossReference; evidences; comments[2].note""}]"	"[{""id"": ""UniProtKB:P23254"", ""source_sha256"": ""8b817c1f08114fe4e1ee8f522e9a539358821497a488f684868cb81eef34af6c"", ""source_version"": ""UniProt 2026_03; entry version 227; sequence version 4; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Transketolase 1 — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23254.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-035_69daefee2312	UniProtKB:P23254	pathwaymech:has_cofactor	CHEBI:29108	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23254	Reviewed protein cofactor annotation in its functional enzyme context. Binds 1 Mg(2+) ion per subunit (PubMed:18186462). Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+) (PubMed:18186462). These metals are alternatives, not simultaneous requirements.	"[{""reference_id"": ""UniProtKB:P23254"", ""source_assertion"": ""COFACTOR identifies CHEBI:29108 (Ca(2+)) with evidence ECO:0000269."", ""source_locator"": ""comments[2].cofactors[1]; cofactorCrossReference; evidences; comments[2].note""}]"	"[{""id"": ""UniProtKB:P23254"", ""source_sha256"": ""8b817c1f08114fe4e1ee8f522e9a539358821497a488f684868cb81eef34af6c"", ""source_version"": ""UniProt 2026_03; entry version 227; sequence version 4; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Transketolase 1 — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23254.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-036_9b03b04d3902	UniProtKB:P23254	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23254	Reviewed protein cofactor annotation in its functional enzyme context. Binds 1 Mg(2+) ion per subunit (PubMed:18186462). Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+) (PubMed:18186462). These metals are alternatives, not simultaneous requirements.	"[{""reference_id"": ""UniProtKB:P23254"", ""source_assertion"": ""COFACTOR identifies CHEBI:29035 (Mn(2+)) with evidence ECO:0000269."", ""source_locator"": ""comments[2].cofactors[2]; cofactorCrossReference; evidences; comments[2].note""}]"	"[{""id"": ""UniProtKB:P23254"", ""source_sha256"": ""8b817c1f08114fe4e1ee8f522e9a539358821497a488f684868cb81eef34af6c"", ""source_version"": ""UniProt 2026_03; entry version 227; sequence version 4; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Transketolase 1 — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23254.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-037_a2c5f08bff6b	UniProtKB:P23254	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23254	Reviewed protein cofactor annotation in its functional enzyme context. Binds 1 Mg(2+) ion per subunit (PubMed:18186462). Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+) (PubMed:18186462). These metals are alternatives, not simultaneous requirements.	"[{""reference_id"": ""UniProtKB:P23254"", ""source_assertion"": ""COFACTOR identifies CHEBI:48828 (Co(2+)) with evidence ECO:0000269."", ""source_locator"": ""comments[2].cofactors[3]; cofactorCrossReference; evidences; comments[2].note""}]"	"[{""id"": ""UniProtKB:P23254"", ""source_sha256"": ""8b817c1f08114fe4e1ee8f522e9a539358821497a488f684868cb81eef34af6c"", ""source_version"": ""UniProt 2026_03; entry version 227; sequence version 4; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Transketolase 1 — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23254.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-038_340de6790f02	UniProtKB:P23254	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23254	Reviewed protein cofactor annotation in its functional enzyme context. Binds 1 thiamine pyrophosphate per subunit.	"[{""reference_id"": ""UniProtKB:P23254"", ""source_assertion"": ""COFACTOR identifies CHEBI:58937 (thiamine diphosphate) with evidence ECO:0000269."", ""source_locator"": ""comments[3].cofactors[0]; cofactorCrossReference; evidences; comments[3].note""}]"	"[{""id"": ""UniProtKB:P23254"", ""source_sha256"": ""8b817c1f08114fe4e1ee8f522e9a539358821497a488f684868cb81eef34af6c"", ""source_version"": ""UniProt 2026_03; entry version 227; sequence version 4; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Transketolase 1 — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P23254.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-039_aeda6d89ddce	UniProtKB:P33315	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33315	Reviewed protein cofactor annotation in its functional enzyme context. Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). The annotation is by similarity; it is not a direct yeast cofactor assay. These metals are alternatives, not simultaneous requirements.	"[{""reference_id"": ""UniProtKB:P33315"", ""source_assertion"": ""COFACTOR identifies CHEBI:18420 (Mg(2+)) with evidence ECO:0000250."", ""source_locator"": ""comments[2].cofactors[0]; cofactorCrossReference; evidences; comments[2].note""}]"	"[{""id"": ""UniProtKB:P33315"", ""source_sha256"": ""8c01246058d0599e4f488cfeea68b88b20b58e3c194a2d8fe63efe1ddb8061ca"", ""source_version"": ""UniProt 2026_03; entry version 199; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Transketolase 2 — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33315.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-040_c3d82e8419ac	UniProtKB:P33315	pathwaymech:has_cofactor	CHEBI:29108	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33315	Reviewed protein cofactor annotation in its functional enzyme context. Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). The annotation is by similarity; it is not a direct yeast cofactor assay. These metals are alternatives, not simultaneous requirements.	"[{""reference_id"": ""UniProtKB:P33315"", ""source_assertion"": ""COFACTOR identifies CHEBI:29108 (Ca(2+)) with evidence ECO:0000250."", ""source_locator"": ""comments[2].cofactors[1]; cofactorCrossReference; evidences; comments[2].note""}]"	"[{""id"": ""UniProtKB:P33315"", ""source_sha256"": ""8c01246058d0599e4f488cfeea68b88b20b58e3c194a2d8fe63efe1ddb8061ca"", ""source_version"": ""UniProt 2026_03; entry version 199; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Transketolase 2 — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33315.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-041_13de0e626bfb	UniProtKB:P33315	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33315	Reviewed protein cofactor annotation in its functional enzyme context. Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). The annotation is by similarity; it is not a direct yeast cofactor assay. These metals are alternatives, not simultaneous requirements.	"[{""reference_id"": ""UniProtKB:P33315"", ""source_assertion"": ""COFACTOR identifies CHEBI:29035 (Mn(2+)) with evidence ECO:0000250."", ""source_locator"": ""comments[2].cofactors[2]; cofactorCrossReference; evidences; comments[2].note""}]"	"[{""id"": ""UniProtKB:P33315"", ""source_sha256"": ""8c01246058d0599e4f488cfeea68b88b20b58e3c194a2d8fe63efe1ddb8061ca"", ""source_version"": ""UniProt 2026_03; entry version 199; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Transketolase 2 — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33315.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-042_fedab874434a	UniProtKB:P33315	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33315	Reviewed protein cofactor annotation in its functional enzyme context. Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). The annotation is by similarity; it is not a direct yeast cofactor assay. These metals are alternatives, not simultaneous requirements.	"[{""reference_id"": ""UniProtKB:P33315"", ""source_assertion"": ""COFACTOR identifies CHEBI:48828 (Co(2+)) with evidence ECO:0000250."", ""source_locator"": ""comments[2].cofactors[3]; cofactorCrossReference; evidences; comments[2].note""}]"	"[{""id"": ""UniProtKB:P33315"", ""source_sha256"": ""8c01246058d0599e4f488cfeea68b88b20b58e3c194a2d8fe63efe1ddb8061ca"", ""source_version"": ""UniProt 2026_03; entry version 199; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Transketolase 2 — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33315.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-043_4d776d608cbc	UniProtKB:P33315	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33315	Reviewed protein cofactor annotation in its functional enzyme context. Binds 1 thiamine pyrophosphate per subunit. The annotation is by similarity; it is not a direct yeast cofactor assay.	"[{""reference_id"": ""UniProtKB:P33315"", ""source_assertion"": ""COFACTOR identifies CHEBI:58937 (thiamine diphosphate) with evidence ECO:0000250."", ""source_locator"": ""comments[3].cofactors[0]; cofactorCrossReference; evidences; comments[3].note""}]"	"[{""id"": ""UniProtKB:P33315"", ""source_sha256"": ""8c01246058d0599e4f488cfeea68b88b20b58e3c194a2d8fe63efe1ddb8061ca"", ""source_version"": ""UniProt 2026_03; entry version 199; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Transketolase 2 — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P33315.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-044_020469e9de10	UniProtKB:P14540	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P14540	Reviewed protein cofactor annotation in its functional enzyme context. Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. The annotation is by similarity; it is not a direct yeast cofactor assay.	"[{""reference_id"": ""UniProtKB:P14540"", ""source_assertion"": ""COFACTOR identifies CHEBI:29105 (Zn(2+)) with evidence ECO:0000250."", ""source_locator"": ""comments[2].cofactors[0]; cofactorCrossReference; evidences; comments[2].note""}]"	"[{""id"": ""UniProtKB:P14540"", ""source_sha256"": ""698ae373a94fdc9d837183616fbd7abb151c52e9ba53fa1b75f874cf6c83255e"", ""source_version"": ""UniProt 2026_03; entry version 224; sequence version 3; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Fructose-bisphosphate aldolase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P14540.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-045_4b5b0a01d61a	UniProtKB:P46969	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P46969	Reviewed protein cofactor annotation in its functional enzyme context. Binds 1 divalent metal cation per subunit. Active with Co(2+), Fe(2+), Mn(2+) and Zn(2+). The annotation is by similarity; it is not a direct yeast cofactor assay. These metals are alternatives, not simultaneous requirements.	"[{""reference_id"": ""UniProtKB:P46969"", ""source_assertion"": ""COFACTOR identifies CHEBI:48828 (Co(2+)) with evidence ECO:0000250."", ""source_locator"": ""comments[2].cofactors[0]; cofactorCrossReference; evidences; comments[2].note""}]"	"[{""id"": ""UniProtKB:P46969"", ""source_sha256"": ""fed3162d8c9c807befb78170e6b1c9fe77413a8fb9e22cb58515d992f7d6fb76"", ""source_version"": ""UniProt 2026_03; entry version 177; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Ribulose-phosphate 3-epimerase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46969.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-046_3b99ab973ee4	UniProtKB:P46969	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P46969	Reviewed protein cofactor annotation in its functional enzyme context. Binds 1 divalent metal cation per subunit. Active with Co(2+), Fe(2+), Mn(2+) and Zn(2+). The annotation is by similarity; it is not a direct yeast cofactor assay. These metals are alternatives, not simultaneous requirements.	"[{""reference_id"": ""UniProtKB:P46969"", ""source_assertion"": ""COFACTOR identifies CHEBI:29033 (Fe(2+)) with evidence ECO:0000250."", ""source_locator"": ""comments[2].cofactors[1]; cofactorCrossReference; evidences; comments[2].note""}]"	"[{""id"": ""UniProtKB:P46969"", ""source_sha256"": ""fed3162d8c9c807befb78170e6b1c9fe77413a8fb9e22cb58515d992f7d6fb76"", ""source_version"": ""UniProt 2026_03; entry version 177; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Ribulose-phosphate 3-epimerase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46969.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-047_0c4e7f0da5bb	UniProtKB:P46969	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P46969	Reviewed protein cofactor annotation in its functional enzyme context. Binds 1 divalent metal cation per subunit. Active with Co(2+), Fe(2+), Mn(2+) and Zn(2+). The annotation is by similarity; it is not a direct yeast cofactor assay. These metals are alternatives, not simultaneous requirements.	"[{""reference_id"": ""UniProtKB:P46969"", ""source_assertion"": ""COFACTOR identifies CHEBI:29035 (Mn(2+)) with evidence ECO:0000250."", ""source_locator"": ""comments[2].cofactors[2]; cofactorCrossReference; evidences; comments[2].note""}]"	"[{""id"": ""UniProtKB:P46969"", ""source_sha256"": ""fed3162d8c9c807befb78170e6b1c9fe77413a8fb9e22cb58515d992f7d6fb76"", ""source_version"": ""UniProt 2026_03; entry version 177; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Ribulose-phosphate 3-epimerase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46969.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-048_f6ca936652ce	UniProtKB:P46969	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P46969	Reviewed protein cofactor annotation in its functional enzyme context. Binds 1 divalent metal cation per subunit. Active with Co(2+), Fe(2+), Mn(2+) and Zn(2+). The annotation is by similarity; it is not a direct yeast cofactor assay. These metals are alternatives, not simultaneous requirements.	"[{""reference_id"": ""UniProtKB:P46969"", ""source_assertion"": ""COFACTOR identifies CHEBI:29105 (Zn(2+)) with evidence ECO:0000250."", ""source_locator"": ""comments[2].cofactors[3]; cofactorCrossReference; evidences; comments[2].note""}]"	"[{""id"": ""UniProtKB:P46969"", ""source_sha256"": ""fed3162d8c9c807befb78170e6b1c9fe77413a8fb9e22cb58515d992f7d6fb76"", ""source_version"": ""UniProt 2026_03; entry version 177; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Ribulose-phosphate 3-epimerase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P46969.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-049_a451610d1656	UniProtKB:P36136	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36136	Reported protein localization, not a claim that every riboneogenic reaction occurs in both compartments or that localization is exclusive.	"[{""reference_id"": ""UniProtKB:P36136"", ""source_assertion"": ""SUBCELLULAR LOCATION lists Cytoplasm with experimental annotation ECO:0000269 citing PMID:14562095."", ""source_locator"": ""comments[4].subcellularLocations[location.value=\""Cytoplasm\""].location; evidences""}]"	"[{""id"": ""UniProtKB:P36136"", ""source_sha256"": ""18e7a733e01ce849a7abd22b93bdf96109baa5e14da63051d42b1a4211be01f1"", ""source_version"": ""UniProt 2026_03; entry version 163; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Sedoheptulose 1,7-bisphosphatase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P36136.json""}]"	""
pathwaymech:PathBank_SMP0002406_riboneogenesis-edge-050_6f2e3ac50c21	UniProtKB:P36136	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36136	Reported protein localization, not a claim that every riboneogenic reaction occurs in both compartments or that localization is exclusive.	"[{""reference_id"": ""UniProtKB:P36136"", ""source_assertion"": ""SUBCELLULAR LOCATION lists Nucleus with experimental annotation ECO:0000269 citing PMID:14562095."", ""source_locator"": ""comments[4].subcellularLocations[location.value=\""Nucleus\""].location; evidences""}]"	"[{""id"": ""UniProtKB:P36136"", ""source_sha256"": ""18e7a733e01ce849a7abd22b93bdf96109baa5e14da63051d42b1a4211be01f1"", ""source_version"": ""UniProt 2026_03; entry version 163; sequence version 1; retrieved 2026-10-10; exact JSON response digest"", ""title"": ""Sedoheptulose 1,7-bisphosphatase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P36136.json""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-001_6271eb606cf1	CHEBI:57844	pathwaymech:consumes	RHEA:21081	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21080		"[{""reference_id"": ""RHEA:21080"", ""source_assertion"": ""Rhea RHEA:21081 lists CHEBI:57844 on its substrates side with coefficient 1."", ""source_locator"": ""RHEA:21081/rh:substrates -> http://rdf.rhea-db.org/21080_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_21080_compound_2530/rh:compound -> http://rdf.rhea-db.org/Compound_2530/rh:accession""}]"	"[{""id"": ""RHEA:21080"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21080 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-002_a920ddf09874	CHEBI:30616	pathwaymech:consumes	RHEA:21081	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21080		"[{""reference_id"": ""RHEA:21080"", ""source_assertion"": ""Rhea RHEA:21081 lists CHEBI:30616 on its substrates side with coefficient 1."", ""source_locator"": ""RHEA:21081/rh:substrates -> http://rdf.rhea-db.org/21080_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_21080_compound_6372/rh:compound -> http://rdf.rhea-db.org/Compound_6372/rh:accession""}]"	"[{""id"": ""RHEA:21080"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21080 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-003_a578534e7083	CHEBI:15377	pathwaymech:consumes	RHEA:21081	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21080		"[{""reference_id"": ""RHEA:21080"", ""source_assertion"": ""Rhea RHEA:21081 lists CHEBI:15377 on its substrates side with coefficient 1."", ""source_locator"": ""RHEA:21081/rh:substrates -> http://rdf.rhea-db.org/21080_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_21080_compound_1283/rh:compound -> http://rdf.rhea-db.org/Compound_1283/rh:accession""}]"	"[{""id"": ""RHEA:21080"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21080 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-004_5e972f61df61	RHEA:21081	pathwaymech:produces	CHEBI:59789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21080		"[{""reference_id"": ""RHEA:21080"", ""source_assertion"": ""Rhea RHEA:21081 lists CHEBI:59789 on its products side with coefficient 1."", ""source_locator"": ""RHEA:21081/rh:products -> http://rdf.rhea-db.org/21080_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_21080_compound_6127/rh:compound -> http://rdf.rhea-db.org/Compound_6127/rh:accession""}]"	"[{""id"": ""RHEA:21080"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21080 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-005_e4502eb50f80	RHEA:21081	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21080		"[{""reference_id"": ""RHEA:21080"", ""source_assertion"": ""Rhea RHEA:21081 lists CHEBI:43474 on its products side with coefficient 1."", ""source_locator"": ""RHEA:21081/rh:products -> http://rdf.rhea-db.org/21080_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_21080_compound_5518/rh:compound -> http://rdf.rhea-db.org/Compound_5518/rh:accession""}]"	"[{""id"": ""RHEA:21080"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21080 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-006_5da85abc4306	RHEA:21081	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21080		"[{""reference_id"": ""RHEA:21080"", ""source_assertion"": ""Rhea RHEA:21081 lists CHEBI:33019 on its products side with coefficient 1."", ""source_locator"": ""RHEA:21081/rh:products -> http://rdf.rhea-db.org/21080_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_21080_compound_2106/rh:compound -> http://rdf.rhea-db.org/Compound_2106/rh:accession""}]"	"[{""id"": ""RHEA:21080"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21080 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-007_32b05e56282b	CHEBI:57856	pathwaymech:consumes	RHEA:17806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17805		"[{""reference_id"": ""RHEA:17805"", ""source_assertion"": ""Rhea RHEA:17806 lists CHEBI:57856 on its substrates side with coefficient 1."", ""source_locator"": ""RHEA:17806/rh:substrates -> http://rdf.rhea-db.org/17805_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_17805_compound_4281/rh:compound -> http://rdf.rhea-db.org/Compound_4281/rh:accession""}]"	"[{""id"": ""RHEA:17805"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:17805 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-008_463747018bc5	CHEBI:15377	pathwaymech:consumes	RHEA:17806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17805		"[{""reference_id"": ""RHEA:17805"", ""source_assertion"": ""Rhea RHEA:17806 lists CHEBI:15377 on its substrates side with coefficient 1."", ""source_locator"": ""RHEA:17806/rh:substrates -> http://rdf.rhea-db.org/17805_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_17805_compound_1283/rh:compound -> http://rdf.rhea-db.org/Compound_1283/rh:accession""}]"	"[{""id"": ""RHEA:17805"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:17805 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-009_068e1b7733f4	RHEA:17806	pathwaymech:produces	CHEBI:58195	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17805		"[{""reference_id"": ""RHEA:17805"", ""source_assertion"": ""Rhea RHEA:17806 lists CHEBI:58195 on its products side with coefficient 1."", ""source_locator"": ""RHEA:17806/rh:products -> http://rdf.rhea-db.org/17805_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_17805_compound_5411/rh:compound -> http://rdf.rhea-db.org/Compound_5411/rh:accession""}]"	"[{""id"": ""RHEA:17805"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:17805 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-010_717c184251ec	RHEA:17806	pathwaymech:produces	CHEBI:16708	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17805		"[{""reference_id"": ""RHEA:17805"", ""source_assertion"": ""Rhea RHEA:17806 lists CHEBI:16708 on its products side with coefficient 1."", ""source_locator"": ""RHEA:17806/rh:products -> http://rdf.rhea-db.org/17805_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_17805_compound_4174/rh:compound -> http://rdf.rhea-db.org/Compound_4174/rh:accession""}]"	"[{""id"": ""RHEA:17805"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:17805 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-011_2ef978b25032	CHEBI:58195	pathwaymech:consumes	RHEA:17754	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17753		"[{""reference_id"": ""RHEA:17753"", ""source_assertion"": ""Rhea RHEA:17754 lists CHEBI:58195 on its substrates side with coefficient 1."", ""source_locator"": ""RHEA:17754/rh:substrates -> http://rdf.rhea-db.org/17753_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_17753_compound_5411/rh:compound -> http://rdf.rhea-db.org/Compound_5411/rh:accession""}]"	"[{""id"": ""RHEA:17753"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:17753 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-012_795b8a44aa26	RHEA:17754	pathwaymech:produces	CHEBI:29484	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17753		"[{""reference_id"": ""RHEA:17753"", ""source_assertion"": ""Rhea RHEA:17754 lists CHEBI:29484 on its products side with coefficient 1."", ""source_locator"": ""RHEA:17754/rh:products -> http://rdf.rhea-db.org/17753_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_17753_compound_5596/rh:compound -> http://rdf.rhea-db.org/Compound_5596/rh:accession""}]"	"[{""id"": ""RHEA:17753"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:17753 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-013_a424d2ba3ddb	RHEA:17754	pathwaymech:produces	CHEBI:58199	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17753		"[{""reference_id"": ""RHEA:17753"", ""source_assertion"": ""Rhea RHEA:17754 lists CHEBI:58199 on its products side with coefficient 1."", ""source_locator"": ""RHEA:17754/rh:products -> http://rdf.rhea-db.org/17753_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_17753_compound_3869/rh:compound -> http://rdf.rhea-db.org/Compound_3869/rh:accession""}]"	"[{""id"": ""RHEA:17753"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:17753 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-014_9e4c9e72efeb	CHEBI:58207	pathwaymech:consumes	RHEA:21197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21196		"[{""reference_id"": ""RHEA:21196"", ""source_assertion"": ""Rhea RHEA:21197 lists CHEBI:58207 on its substrates side with coefficient 1."", ""source_locator"": ""RHEA:21197/rh:substrates -> http://rdf.rhea-db.org/21196_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_21196_compound_3620/rh:compound -> http://rdf.rhea-db.org/Compound_3620/rh:accession""}]"	"[{""id"": ""RHEA:21196"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21196 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-015_130a5bac44a1	CHEBI:58199	pathwaymech:consumes	RHEA:21197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21196		"[{""reference_id"": ""RHEA:21196"", ""source_assertion"": ""Rhea RHEA:21197 lists CHEBI:58199 on its substrates side with coefficient 1."", ""source_locator"": ""RHEA:21197/rh:substrates -> http://rdf.rhea-db.org/21196_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_21196_compound_3869/rh:compound -> http://rdf.rhea-db.org/Compound_3869/rh:accession""}]"	"[{""id"": ""RHEA:21196"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21196 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-016_fc154c6fb119	RHEA:21197	pathwaymech:produces	CHEBI:58140	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21196		"[{""reference_id"": ""RHEA:21196"", ""source_assertion"": ""Rhea RHEA:21197 lists CHEBI:58140 on its products side with coefficient 1."", ""source_locator"": ""RHEA:21197/rh:products -> http://rdf.rhea-db.org/21196_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_21196_compound_4911/rh:compound -> http://rdf.rhea-db.org/Compound_4911/rh:accession""}]"	"[{""id"": ""RHEA:21196"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21196 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-017_39074d52412a	RHEA:21197	pathwaymech:produces	CHEBI:57844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21196		"[{""reference_id"": ""RHEA:21196"", ""source_assertion"": ""Rhea RHEA:21197 lists CHEBI:57844 on its products side with coefficient 1."", ""source_locator"": ""RHEA:21197/rh:products -> http://rdf.rhea-db.org/21196_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_21196_compound_2530/rh:compound -> http://rdf.rhea-db.org/Compound_2530/rh:accession""}]"	"[{""id"": ""RHEA:21196"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21196 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-018_2fdfb0ccd790	CHEBI:18608	pathwaymech:consumes	RHEA:11173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11172		"[{""reference_id"": ""RHEA:11172"", ""source_assertion"": ""Rhea RHEA:11173 lists CHEBI:18608 on its substrates side with coefficient 1."", ""source_locator"": ""RHEA:11173/rh:substrates -> http://rdf.rhea-db.org/11172_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_11172_compound_1195/rh:compound -> http://rdf.rhea-db.org/Compound_1195/rh:accession""}]"	"[{""id"": ""RHEA:11172"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:11172 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-019_4a5a80f376b4	CHEBI:58199	pathwaymech:consumes	RHEA:11173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11172		"[{""reference_id"": ""RHEA:11172"", ""source_assertion"": ""Rhea RHEA:11173 lists CHEBI:58199 on its substrates side with coefficient 1."", ""source_locator"": ""RHEA:11173/rh:substrates -> http://rdf.rhea-db.org/11172_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_11172_compound_3869/rh:compound -> http://rdf.rhea-db.org/Compound_3869/rh:accession""}]"	"[{""id"": ""RHEA:11172"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:11172 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-020_db28105057d6	RHEA:11173	pathwaymech:produces	CHEBI:57453	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11172		"[{""reference_id"": ""RHEA:11172"", ""source_assertion"": ""Rhea RHEA:11173 lists CHEBI:57453 on its products side with coefficient 1."", ""source_locator"": ""RHEA:11173/rh:products -> http://rdf.rhea-db.org/11172_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_11172_compound_4996/rh:compound -> http://rdf.rhea-db.org/Compound_4996/rh:accession""}]"	"[{""id"": ""RHEA:11172"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:11172 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-021_f355922e1e6e	RHEA:11173	pathwaymech:produces	CHEBI:57844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11172		"[{""reference_id"": ""RHEA:11172"", ""source_assertion"": ""Rhea RHEA:11173 lists CHEBI:57844 on its products side with coefficient 1."", ""source_locator"": ""RHEA:11173/rh:products -> http://rdf.rhea-db.org/11172_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_11172_compound_2530/rh:compound -> http://rdf.rhea-db.org/Compound_2530/rh:accession""}]"	"[{""id"": ""RHEA:11172"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:11172 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-022_054c6a9ce3ed	CHEBI:59789	pathwaymech:consumes	MetaCyc:RXN-7605	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-7605|MetaCyc:S-ADENOSYLMETHIONINE		"[{""reference_id"": ""MetaCyc:RXN-7605"", ""source_assertion"": ""RXN-7605 places S-ADENOSYLMETHIONINE on its left side with implicit coefficient 1; this is a generic methyl-transfer reaction, not a specified methylation target."", ""source_locator"": ""Reaction[@frameid='RXN-7605']/left/Compound[@frameid='S-ADENOSYLMETHIONINE']; comment; reaction-direction""}, {""reference_id"": ""MetaCyc:S-ADENOSYLMETHIONINE"", ""source_assertion"": ""The native S-ADENOSYLMETHIONINE compound cross-references CHEBI:59789."", ""source_locator"": ""Compound[@frameid='S-ADENOSYLMETHIONINE']/dblink[dblink-db='CHEBI']/dblink-oid""}]"	"[{""id"": ""MetaCyc:RXN-7605"", ""source_sha256"": ""f44fc8d5f627e20f1b41f289ff89e733586b62c4c65ec0b1bd9696eedee998ef"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN-7605"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-7605""}, {""id"": ""MetaCyc:S-ADENOSYLMETHIONINE"", ""source_sha256"": ""1f1a6d61f3e5156bf82f8f0f0b2395c691808db85764e0c0e44d75cf99fe0b3b"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc S-adenosyl-L-methionine"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:S-ADENOSYLMETHIONINE""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-023_7134e320245d	MetaCyc:Demethylated-methyl-acceptors	pathwaymech:consumes	MetaCyc:RXN-7605	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Demethylated-methyl-acceptors|MetaCyc:RXN-7605	A generic chemical class is retained without identifying a particular small molecule, protein, RNA or DNA substrate.	"[{""reference_id"": ""MetaCyc:RXN-7605"", ""source_assertion"": ""RXN-7605 places Demethylated-methyl-acceptors on its left side with implicit coefficient 1; this is a generic methyl-transfer reaction, not a specified methylation target."", ""source_locator"": ""Reaction[@frameid='RXN-7605']/left/Compound[@frameid='Demethylated-methyl-acceptors']; comment; reaction-direction""}, {""reference_id"": ""MetaCyc:Demethylated-methyl-acceptors"", ""source_assertion"": ""The class leaves the methyl donor or acceptor identity undefined; the donor wording is its native label, while this reaction determines its acceptor role."", ""source_locator"": ""Compound[@frameid='Demethylated-methyl-acceptors']/common-name, synonym, comment; cml/molecule""}]"	"[{""id"": ""MetaCyc:Demethylated-methyl-acceptors"", ""source_sha256"": ""ef9cf0464f2e12361b06fa69afa57aee6be43ceeeb9484349293eafc51be553e"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc a demethylated methyl donor"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Demethylated-methyl-acceptors""}, {""id"": ""MetaCyc:RXN-7605"", ""source_sha256"": ""f44fc8d5f627e20f1b41f289ff89e733586b62c4c65ec0b1bd9696eedee998ef"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN-7605"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-7605""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-024_55fba4e496d4	MetaCyc:RXN-7605	pathwaymech:produces	CHEBI:57856	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ADENOSYL-HOMO-CYS|MetaCyc:RXN-7605		"[{""reference_id"": ""MetaCyc:RXN-7605"", ""source_assertion"": ""RXN-7605 places ADENOSYL-HOMO-CYS on its right side with implicit coefficient 1; this is a generic methyl-transfer reaction, not a specified methylation target."", ""source_locator"": ""Reaction[@frameid='RXN-7605']/right/Compound[@frameid='ADENOSYL-HOMO-CYS']; comment; reaction-direction""}, {""reference_id"": ""MetaCyc:ADENOSYL-HOMO-CYS"", ""source_assertion"": ""The native ADENOSYL-HOMO-CYS compound cross-references CHEBI:57856."", ""source_locator"": ""Compound[@frameid='ADENOSYL-HOMO-CYS']/dblink[dblink-db='CHEBI']/dblink-oid""}]"	"[{""id"": ""MetaCyc:ADENOSYL-HOMO-CYS"", ""source_sha256"": ""30ac63e3204f75a08ac4611e2fb2a3e06716641a9e7e767a0a3cb4c38e53867f"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc S-adenosyl-L-homocysteine"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADENOSYL-HOMO-CYS""}, {""id"": ""MetaCyc:RXN-7605"", ""source_sha256"": ""f44fc8d5f627e20f1b41f289ff89e733586b62c4c65ec0b1bd9696eedee998ef"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN-7605"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-7605""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-025_7012e35c2a6c	MetaCyc:RXN-7605	pathwaymech:produces	MetaCyc:Methylated-methyl-acceptors	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:Methylated-methyl-acceptors|MetaCyc:RXN-7605	A generic chemical class is retained without identifying a particular small molecule, protein, RNA or DNA substrate.	"[{""reference_id"": ""MetaCyc:RXN-7605"", ""source_assertion"": ""RXN-7605 places Methylated-methyl-acceptors on its right side with implicit coefficient 1; this is a generic methyl-transfer reaction, not a specified methylation target."", ""source_locator"": ""Reaction[@frameid='RXN-7605']/right/Compound[@frameid='Methylated-methyl-acceptors']; comment; reaction-direction""}, {""reference_id"": ""MetaCyc:Methylated-methyl-acceptors"", ""source_assertion"": ""The class leaves the methyl donor or acceptor identity undefined; the donor wording is its native label, while this reaction determines its acceptor role."", ""source_locator"": ""Compound[@frameid='Methylated-methyl-acceptors']/common-name, synonym, comment; cml/molecule""}]"	"[{""id"": ""MetaCyc:Methylated-methyl-acceptors"", ""source_sha256"": ""fdad0a0d34db04b07b326310509b5a1bcbfa2c2c48766eee74a58331e0122f2b"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc a methylated methyl donor"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:Methylated-methyl-acceptors""}, {""id"": ""MetaCyc:RXN-7605"", ""source_sha256"": ""f44fc8d5f627e20f1b41f289ff89e733586b62c4c65ec0b1bd9696eedee998ef"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN-7605"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-7605""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-026_b1e7f49ab107	MetaCyc:RXN-7605	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PROTON|MetaCyc:RXN-7605		"[{""reference_id"": ""MetaCyc:RXN-7605"", ""source_assertion"": ""RXN-7605 places PROTON on its right side with implicit coefficient 1; this is a generic methyl-transfer reaction, not a specified methylation target."", ""source_locator"": ""Reaction[@frameid='RXN-7605']/right/Compound[@frameid='PROTON']; comment; reaction-direction""}, {""reference_id"": ""MetaCyc:PROTON"", ""source_assertion"": ""The native PROTON compound cross-references CHEBI:15378."", ""source_locator"": ""Compound[@frameid='PROTON']/dblink[dblink-db='CHEBI']/dblink-oid""}]"	"[{""id"": ""MetaCyc:PROTON"", ""source_sha256"": ""2df2c98d80ad6c76b622e5ff6d31e50244f036b3ecb26f4a0b647cf195029eb7"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc H+"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PROTON""}, {""id"": ""MetaCyc:RXN-7605"", ""source_sha256"": ""f44fc8d5f627e20f1b41f289ff89e733586b62c4c65ec0b1bd9696eedee998ef"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN-7605"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-7605""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-027_3e5f8c37a96a	RHEA:21081	BFO:0000050	MetaCyc:PWY-6151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6151|MetaCyc:S-ADENMETSYN-RXN|MetaCyc:SAM-PWY|RHEA:21080		"[{""reference_id"": ""MetaCyc:PWY-6151"", ""source_assertion"": ""PWY-6151 includes child pathway SAM-PWY."", ""source_locator"": ""Pathway[@frameid='PWY-6151']/reaction-list/Pathway[@frameid='SAM-PWY']""}, {""reference_id"": ""MetaCyc:SAM-PWY"", ""source_assertion"": ""SAM-PWY contains only S-ADENMETSYN-RXN, laid out left to right."", ""source_locator"": ""Pathway[@frameid='SAM-PWY']/reaction-list; reaction-layout""}, {""reference_id"": ""MetaCyc:S-ADENMETSYN-RXN"", ""source_assertion"": ""S-ADENMETSYN-RXN explicitly cross-references RHEA:21081."", ""source_locator"": ""Reaction[@frameid='S-ADENMETSYN-RXN']/dblink[dblink-db='RHEA']; reaction-direction""}, {""reference_id"": ""RHEA:21080"", ""source_assertion"": ""Rhea master 21080 has directed left-to-right reaction 21081."", ""source_locator"": ""http://rdf.rhea-db.org/21080/rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:PWY-6151"", ""source_sha256"": ""87d0c3c8c47350b1d8b6d19b37db114428dbb2e7cb527936eae58543d0e41fa7"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc S-adenosyl-L-methionine cycle I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6151""}, {""id"": ""MetaCyc:S-ADENMETSYN-RXN"", ""source_sha256"": ""861cd881d1175649d8a25c6294418ac686c412a72ee7e8031feecdc2780c9ce2"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc S-ADENMETSYN-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:S-ADENMETSYN-RXN""}, {""id"": ""MetaCyc:SAM-PWY"", ""source_sha256"": ""ee0359d30840846650d89bfd872b6886f691e3416f97917de3afb698ca6ee82b"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc S-adenosyl-L-methionine biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:SAM-PWY""}, {""id"": ""RHEA:21080"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21080 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-028_0931b616e8c8	RHEA:17806	BFO:0000050	MetaCyc:PWY-6151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN|MetaCyc:PWY-6151|RHEA:17805		"[{""reference_id"": ""MetaCyc:PWY-6151"", ""source_assertion"": ""PWY-6151 contains ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN and selects its left-to-right pathway layout."", ""source_locator"": ""Pathway[@frameid='PWY-6151']/reaction-list/Reaction[@frameid='ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN']; reaction-layout""}, {""reference_id"": ""MetaCyc:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN"", ""source_assertion"": ""ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN explicitly cross-references RHEA:17806."", ""source_locator"": ""Reaction[@frameid='ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN']/dblink[dblink-db='RHEA']; reaction-direction""}, {""reference_id"": ""RHEA:17805"", ""source_assertion"": ""Rhea master 17805 has directed left-to-right reaction 17806."", ""source_locator"": ""http://rdf.rhea-db.org/17805/rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN"", ""source_sha256"": ""885710a635de7d85420049a5f5c62f906d9ceb3954c5893099afa832ebe8d97a"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN""}, {""id"": ""MetaCyc:PWY-6151"", ""source_sha256"": ""87d0c3c8c47350b1d8b6d19b37db114428dbb2e7cb527936eae58543d0e41fa7"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc S-adenosyl-L-methionine cycle I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6151""}, {""id"": ""RHEA:17805"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:17805 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-029_b43bdc3e4f67	RHEA:17754	BFO:0000050	MetaCyc:PWY-6151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6151|MetaCyc:RIBOSYLHOMOCYSTEINASE-RXN|RHEA:17753		"[{""reference_id"": ""MetaCyc:PWY-6151"", ""source_assertion"": ""PWY-6151 contains RIBOSYLHOMOCYSTEINASE-RXN and selects its left-to-right pathway layout."", ""source_locator"": ""Pathway[@frameid='PWY-6151']/reaction-list/Reaction[@frameid='RIBOSYLHOMOCYSTEINASE-RXN']; reaction-layout""}, {""reference_id"": ""MetaCyc:RIBOSYLHOMOCYSTEINASE-RXN"", ""source_assertion"": ""RIBOSYLHOMOCYSTEINASE-RXN explicitly cross-references RHEA:17754."", ""source_locator"": ""Reaction[@frameid='RIBOSYLHOMOCYSTEINASE-RXN']/dblink[dblink-db='RHEA']; reaction-direction""}, {""reference_id"": ""RHEA:17753"", ""source_assertion"": ""Rhea master 17753 has directed left-to-right reaction 17754."", ""source_locator"": ""http://rdf.rhea-db.org/17753/rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:PWY-6151"", ""source_sha256"": ""87d0c3c8c47350b1d8b6d19b37db114428dbb2e7cb527936eae58543d0e41fa7"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc S-adenosyl-L-methionine cycle I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6151""}, {""id"": ""MetaCyc:RIBOSYLHOMOCYSTEINASE-RXN"", ""source_sha256"": ""6cfeb96efc5691edeb6ab3acbc891e64ab1c52dc84e9941a9a13b8536959b5ad"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RIBOSYLHOMOCYSTEINASE-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RIBOSYLHOMOCYSTEINASE-RXN""}, {""id"": ""RHEA:17753"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:17753 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-030_24ffbd52c470	RHEA:21197	BFO:0000050	MetaCyc:PWY-6151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HOMOCYSMET-RXN|MetaCyc:PWY-6151|RHEA:21196		"[{""reference_id"": ""MetaCyc:PWY-6151"", ""source_assertion"": ""PWY-6151 contains HOMOCYSMET-RXN and selects its left-to-right pathway layout."", ""source_locator"": ""Pathway[@frameid='PWY-6151']/reaction-list/Reaction[@frameid='HOMOCYSMET-RXN']; reaction-layout""}, {""reference_id"": ""MetaCyc:HOMOCYSMET-RXN"", ""source_assertion"": ""HOMOCYSMET-RXN explicitly cross-references RHEA:21199; its standalone reaction direction is REVERSIBLE."", ""source_locator"": ""Reaction[@frameid='HOMOCYSMET-RXN']/dblink[dblink-db='RHEA']; reaction-direction""}, {""reference_id"": ""RHEA:21196"", ""source_assertion"": ""Rhea master 21196 has directed left-to-right reaction 21197 and bidirectional reaction 21199."", ""source_locator"": ""http://rdf.rhea-db.org/21196/rh:directionalReaction; rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:HOMOCYSMET-RXN"", ""source_sha256"": ""65cf669c8dd1fd78639a7feee5244d15a3fb47a75eabb57cc82df6e954e1b20a"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc HOMOCYSMET-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HOMOCYSMET-RXN""}, {""id"": ""MetaCyc:PWY-6151"", ""source_sha256"": ""87d0c3c8c47350b1d8b6d19b37db114428dbb2e7cb527936eae58543d0e41fa7"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc S-adenosyl-L-methionine cycle I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6151""}, {""id"": ""RHEA:21196"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21196 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-031_a3823c12c934	RHEA:11173	BFO:0000050	MetaCyc:PWY-6151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HOMOCYSMETB12-RXN|MetaCyc:PWY-6151|RHEA:11172	MetH alternative, represented by the current monoglutamate Rhea equation; native HOMOCYSMETB12-RXN permits an unspecified folate glutamate-chain length. This does not make monoglutamate the exclusive cellular substrate.	"[{""reference_id"": ""MetaCyc:PWY-6151"", ""source_assertion"": ""The pathway comment explicitly permits cobalamin-dependent methionine synthase as an alternative to the independent enzyme and states that E. coli has both."", ""source_locator"": ""Pathway[@frameid='PWY-6151']/comment; paragraph beginning 'The cycle continues'""}, {""reference_id"": ""MetaCyc:HOMOCYSMETB12-RXN"", ""source_assertion"": ""HOMOCYSMETB12-RXN explicitly cross-references RHEA:11173."", ""source_locator"": ""Reaction[@frameid='HOMOCYSMETB12-RXN']/dblink[dblink-db='RHEA']; reaction-direction""}, {""reference_id"": ""RHEA:11172"", ""source_assertion"": ""Rhea master 11172 has directed left-to-right reaction 11173."", ""source_locator"": ""http://rdf.rhea-db.org/11172/rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:HOMOCYSMETB12-RXN"", ""source_sha256"": ""b60651147f79ab2b4e25a7501ff58f9c35c4b9a4d607f501c76f414e6a8b7c75"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc HOMOCYSMETB12-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HOMOCYSMETB12-RXN""}, {""id"": ""MetaCyc:PWY-6151"", ""source_sha256"": ""87d0c3c8c47350b1d8b6d19b37db114428dbb2e7cb527936eae58543d0e41fa7"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc S-adenosyl-L-methionine cycle I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6151""}, {""id"": ""RHEA:11172"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:11172 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-032_0688a212454c	MetaCyc:RXN-7605	BFO:0000050	MetaCyc:PWY-6151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6151		"[{""reference_id"": ""MetaCyc:PWY-6151"", ""source_assertion"": ""PWY-6151 contains the generic methyl-transfer reaction RXN-7605, laid out left to right."", ""source_locator"": ""Pathway[@frameid='PWY-6151']/reaction-list/Reaction[@frameid='RXN-7605']; reaction-layout""}]"	"[{""id"": ""MetaCyc:PWY-6151"", ""source_sha256"": ""87d0c3c8c47350b1d8b6d19b37db114428dbb2e7cb527936eae58543d0e41fa7"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc S-adenosyl-L-methionine cycle I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6151""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-033_9ddaaa6a219e	RHEA:21197	pathwaymech:precedes	RHEA:21081	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6151|RHEA:21080|RHEA:21196	The source-defined cycle closes through CHEBI:57844; ordering does not assert an irreversible thermodynamic constraint.	"[{""reference_id"": ""MetaCyc:PWY-6151"", ""source_assertion"": ""Native pathway ordering places HOMOCYSMET-RXN before S-ADENMETSYN-RXN."", ""source_locator"": ""Pathway/reaction-ordering[Reaction/@frameid='S-ADENMETSYN-RXN']/predecessor-reactions/Reaction[@frameid='HOMOCYSMET-RXN']""}, {""reference_id"": ""RHEA:21196"", ""source_assertion"": ""Rhea RHEA:21197 lists CHEBI:57844 on its products side with coefficient 1."", ""source_locator"": ""RHEA:21197/rh:products -> http://rdf.rhea-db.org/21196_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_21196_compound_2530/rh:compound -> http://rdf.rhea-db.org/Compound_2530/rh:accession""}, {""reference_id"": ""RHEA:21080"", ""source_assertion"": ""Rhea RHEA:21081 lists CHEBI:57844 on its substrates side with coefficient 1."", ""source_locator"": ""RHEA:21081/rh:substrates -> http://rdf.rhea-db.org/21080_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_21080_compound_2530/rh:compound -> http://rdf.rhea-db.org/Compound_2530/rh:accession""}]"	"[{""id"": ""MetaCyc:PWY-6151"", ""source_sha256"": ""87d0c3c8c47350b1d8b6d19b37db114428dbb2e7cb527936eae58543d0e41fa7"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc S-adenosyl-L-methionine cycle I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6151""}, {""id"": ""RHEA:21080"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21080 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:21196"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21196 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-034_5563327b9c87	RHEA:21081	pathwaymech:precedes	MetaCyc:RXN-7605	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6151|MetaCyc:RXN-7605|RHEA:21080	The source-defined cycle closes through CHEBI:59789; ordering does not assert an irreversible thermodynamic constraint.	"[{""reference_id"": ""MetaCyc:PWY-6151"", ""source_assertion"": ""Native pathway ordering places S-ADENMETSYN-RXN before RXN-7605."", ""source_locator"": ""Pathway/reaction-ordering[Reaction/@frameid='RXN-7605']/predecessor-reactions/Reaction[@frameid='S-ADENMETSYN-RXN']""}, {""reference_id"": ""RHEA:21080"", ""source_assertion"": ""Rhea RHEA:21081 lists CHEBI:59789 on its products side with coefficient 1."", ""source_locator"": ""RHEA:21081/rh:products -> http://rdf.rhea-db.org/21080_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_21080_compound_6127/rh:compound -> http://rdf.rhea-db.org/Compound_6127/rh:accession""}, {""reference_id"": ""MetaCyc:RXN-7605"", ""source_assertion"": ""RXN-7605 places S-ADENOSYLMETHIONINE on its left side with implicit coefficient 1; this is a generic methyl-transfer reaction, not a specified methylation target."", ""source_locator"": ""Reaction[@frameid='RXN-7605']/left/Compound[@frameid='S-ADENOSYLMETHIONINE']; comment; reaction-direction""}]"	"[{""id"": ""MetaCyc:PWY-6151"", ""source_sha256"": ""87d0c3c8c47350b1d8b6d19b37db114428dbb2e7cb527936eae58543d0e41fa7"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc S-adenosyl-L-methionine cycle I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6151""}, {""id"": ""MetaCyc:RXN-7605"", ""source_sha256"": ""f44fc8d5f627e20f1b41f289ff89e733586b62c4c65ec0b1bd9696eedee998ef"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN-7605"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-7605""}, {""id"": ""RHEA:21080"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21080 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-035_6fcbdc2159ec	MetaCyc:RXN-7605	pathwaymech:precedes	RHEA:17806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6151|MetaCyc:RXN-7605|RHEA:17805	The source-defined cycle closes through CHEBI:57856; ordering does not assert an irreversible thermodynamic constraint.	"[{""reference_id"": ""MetaCyc:PWY-6151"", ""source_assertion"": ""Native pathway ordering places RXN-7605 before ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN."", ""source_locator"": ""Pathway/reaction-ordering[Reaction/@frameid='ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN']/predecessor-reactions/Reaction[@frameid='RXN-7605']""}, {""reference_id"": ""MetaCyc:RXN-7605"", ""source_assertion"": ""RXN-7605 places ADENOSYL-HOMO-CYS on its right side with implicit coefficient 1; this is a generic methyl-transfer reaction, not a specified methylation target."", ""source_locator"": ""Reaction[@frameid='RXN-7605']/right/Compound[@frameid='ADENOSYL-HOMO-CYS']; comment; reaction-direction""}, {""reference_id"": ""RHEA:17805"", ""source_assertion"": ""Rhea RHEA:17806 lists CHEBI:57856 on its substrates side with coefficient 1."", ""source_locator"": ""RHEA:17806/rh:substrates -> http://rdf.rhea-db.org/17805_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_17805_compound_4281/rh:compound -> http://rdf.rhea-db.org/Compound_4281/rh:accession""}]"	"[{""id"": ""MetaCyc:PWY-6151"", ""source_sha256"": ""87d0c3c8c47350b1d8b6d19b37db114428dbb2e7cb527936eae58543d0e41fa7"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc S-adenosyl-L-methionine cycle I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6151""}, {""id"": ""MetaCyc:RXN-7605"", ""source_sha256"": ""f44fc8d5f627e20f1b41f289ff89e733586b62c4c65ec0b1bd9696eedee998ef"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc RXN-7605"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-7605""}, {""id"": ""RHEA:17805"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:17805 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-036_640dbfa03515	RHEA:17806	pathwaymech:precedes	RHEA:17754	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6151|RHEA:17753|RHEA:17805	The source-defined cycle closes through CHEBI:58195; ordering does not assert an irreversible thermodynamic constraint.	"[{""reference_id"": ""MetaCyc:PWY-6151"", ""source_assertion"": ""Native pathway ordering places ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN before RIBOSYLHOMOCYSTEINASE-RXN."", ""source_locator"": ""Pathway/reaction-ordering[Reaction/@frameid='RIBOSYLHOMOCYSTEINASE-RXN']/predecessor-reactions/Reaction[@frameid='ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN']""}, {""reference_id"": ""RHEA:17805"", ""source_assertion"": ""Rhea RHEA:17806 lists CHEBI:58195 on its products side with coefficient 1."", ""source_locator"": ""RHEA:17806/rh:products -> http://rdf.rhea-db.org/17805_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_17805_compound_5411/rh:compound -> http://rdf.rhea-db.org/Compound_5411/rh:accession""}, {""reference_id"": ""RHEA:17753"", ""source_assertion"": ""Rhea RHEA:17754 lists CHEBI:58195 on its substrates side with coefficient 1."", ""source_locator"": ""RHEA:17754/rh:substrates -> http://rdf.rhea-db.org/17753_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_17753_compound_5411/rh:compound -> http://rdf.rhea-db.org/Compound_5411/rh:accession""}]"	"[{""id"": ""MetaCyc:PWY-6151"", ""source_sha256"": ""87d0c3c8c47350b1d8b6d19b37db114428dbb2e7cb527936eae58543d0e41fa7"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc S-adenosyl-L-methionine cycle I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6151""}, {""id"": ""RHEA:17753"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:17753 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:17805"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:17805 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-037_b42037930ce8	RHEA:17754	pathwaymech:precedes	RHEA:21197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6151|RHEA:17753|RHEA:21196	The source-defined cycle closes through CHEBI:58199; ordering does not assert an irreversible thermodynamic constraint.	"[{""reference_id"": ""MetaCyc:PWY-6151"", ""source_assertion"": ""Native pathway ordering places RIBOSYLHOMOCYSTEINASE-RXN before HOMOCYSMET-RXN."", ""source_locator"": ""Pathway/reaction-ordering[Reaction/@frameid='HOMOCYSMET-RXN']/predecessor-reactions/Reaction[@frameid='RIBOSYLHOMOCYSTEINASE-RXN']""}, {""reference_id"": ""RHEA:17753"", ""source_assertion"": ""Rhea RHEA:17754 lists CHEBI:58199 on its products side with coefficient 1."", ""source_locator"": ""RHEA:17754/rh:products -> http://rdf.rhea-db.org/17753_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_17753_compound_3869/rh:compound -> http://rdf.rhea-db.org/Compound_3869/rh:accession""}, {""reference_id"": ""RHEA:21196"", ""source_assertion"": ""Rhea RHEA:21197 lists CHEBI:58199 on its substrates side with coefficient 1."", ""source_locator"": ""RHEA:21197/rh:substrates -> http://rdf.rhea-db.org/21196_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_21196_compound_3869/rh:compound -> http://rdf.rhea-db.org/Compound_3869/rh:accession""}]"	"[{""id"": ""MetaCyc:PWY-6151"", ""source_sha256"": ""87d0c3c8c47350b1d8b6d19b37db114428dbb2e7cb527936eae58543d0e41fa7"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc S-adenosyl-L-methionine cycle I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6151""}, {""id"": ""RHEA:17753"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:17753 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:21196"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21196 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-038_afa6d44d81c6	RHEA:17754	RO:0002413	RHEA:11173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6151|RHEA:11172|RHEA:17753	Material continuity for the documented MetH alternative, not an additional native reaction-ordering triple.	"[{""reference_id"": ""MetaCyc:PWY-6151"", ""source_assertion"": ""The pathway comment permits MetH as an alternative methionine-regenerating enzyme in E. coli."", ""source_locator"": ""Pathway[@frameid='PWY-6151']/comment; methionine synthase alternatives""}, {""reference_id"": ""RHEA:17753"", ""source_assertion"": ""Rhea RHEA:17754 lists CHEBI:58199 on its products side with coefficient 1."", ""source_locator"": ""RHEA:17754/rh:products -> http://rdf.rhea-db.org/17753_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_17753_compound_3869/rh:compound -> http://rdf.rhea-db.org/Compound_3869/rh:accession""}, {""reference_id"": ""RHEA:11172"", ""source_assertion"": ""Rhea RHEA:11173 lists CHEBI:58199 on its substrates side with coefficient 1."", ""source_locator"": ""RHEA:11173/rh:substrates -> http://rdf.rhea-db.org/11172_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_11172_compound_3869/rh:compound -> http://rdf.rhea-db.org/Compound_3869/rh:accession""}]"	"[{""id"": ""MetaCyc:PWY-6151"", ""source_sha256"": ""87d0c3c8c47350b1d8b6d19b37db114428dbb2e7cb527936eae58543d0e41fa7"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc S-adenosyl-L-methionine cycle I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6151""}, {""id"": ""RHEA:11172"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:11172 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:17753"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:17753 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-039_48ef678a7248	RHEA:11173	RO:0002413	RHEA:21081	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6151|RHEA:11172|RHEA:21080	Material continuity for the documented MetH alternative, not an additional native reaction-ordering triple.	"[{""reference_id"": ""MetaCyc:PWY-6151"", ""source_assertion"": ""The pathway comment permits MetH as an alternative methionine-regenerating enzyme in E. coli."", ""source_locator"": ""Pathway[@frameid='PWY-6151']/comment; methionine synthase alternatives""}, {""reference_id"": ""RHEA:11172"", ""source_assertion"": ""Rhea RHEA:11173 lists CHEBI:57844 on its products side with coefficient 1."", ""source_locator"": ""RHEA:11173/rh:products -> http://rdf.rhea-db.org/11172_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_11172_compound_2530/rh:compound -> http://rdf.rhea-db.org/Compound_2530/rh:accession""}, {""reference_id"": ""RHEA:21080"", ""source_assertion"": ""Rhea RHEA:21081 lists CHEBI:57844 on its substrates side with coefficient 1."", ""source_locator"": ""RHEA:21081/rh:substrates -> http://rdf.rhea-db.org/21080_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_21080_compound_2530/rh:compound -> http://rdf.rhea-db.org/Compound_2530/rh:accession""}]"	"[{""id"": ""MetaCyc:PWY-6151"", ""source_sha256"": ""87d0c3c8c47350b1d8b6d19b37db114428dbb2e7cb527936eae58543d0e41fa7"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc S-adenosyl-L-methionine cycle I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6151""}, {""id"": ""RHEA:11172"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:11172 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:21080"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21080 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-040_7d02714a4758	MetaCyc:S-ADENMETSYN-CPLX	BFO:0000051	UniProtKB:P0A817	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:S-ADENMETSYN-CPLX|MetaCyc:S-ADENMETSYN-MONOMER|PMID:14967023|UniProtKB:P0A817	Source subunit coefficient 4; the protein component is not asserted to independently catalyze the overall reaction.	"[{""reference_id"": ""MetaCyc:S-ADENMETSYN-CPLX"", ""source_assertion"": ""The native complex contains 4 copies of S-ADENMETSYN-MONOMER."", ""source_locator"": ""Protein[@frameid='S-ADENMETSYN-CPLX']/component/Protein; component/coefficient""}, {""reference_id"": ""MetaCyc:S-ADENMETSYN-MONOMER"", ""source_assertion"": ""S-ADENMETSYN-MONOMER is unified with UniProtKB:P0A817."", ""source_locator"": ""Protein[@frameid='S-ADENMETSYN-MONOMER']/dblink[dblink-db='UNIPROT']""}, {""reference_id"": ""UniProtKB:P0A817"", ""source_assertion"": ""The reviewed SUBUNIT annotation describes a homotetramer (dimer of dimers), with experimental ECO:0000269 evidence."", ""source_locator"": ""comments[commentType='SUBUNIT']""}, {""reference_id"": ""PMID:14967023"", ""source_assertion"": ""The E. coli crystal structure is a dimer of dimers."", ""source_locator"": ""Europe PMC resultList.result[0].abstractText; structural Results""}]"	"[{""id"": ""MetaCyc:S-ADENMETSYN-CPLX"", ""source_sha256"": ""7f904a9c12927ae298b6a61c92374ec46bae8639da53b822521d5cc5ea40f83b"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc methionine adenosyltransferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:S-ADENMETSYN-CPLX""}, {""id"": ""MetaCyc:S-ADENMETSYN-MONOMER"", ""source_sha256"": ""ee2c005d545bf92ea83b17ced4dd381de6beb1fc2e42ce8c09f4f4f7cac5ebcb"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc methionine adenosyltransferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:S-ADENMETSYN-MONOMER""}, {""id"": ""PMID:14967023"", ""source_sha256"": ""002ca7c6ec99f6dc4c1ad7030ff1f1c9f8c6eb9a37286d2a40d7b3776546bbf5"", ""source_version"": ""Original article 2004-02-01; inspected Europe PMC core record abstract, not full text"", ""title"": ""Crystal structure of the S-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of S-adenosylmethionine synthesis from ATP and Met."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14967023%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P0A817"", ""source_sha256"": ""96b4db3c9596a1e779bbc1d1459e6024981eadaa10ad79a446ee228373293d98"", ""source_version"": ""2026_03, released 2026-09-02; full JSON"", ""title"": ""UniProtKB reviewed S-adenosylmethionine synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A817.json""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-041_81a624cfc2ff	MetaCyc:CPLX0-1541	BFO:0000051	UniProtKB:P0AF12	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-1541|MetaCyc:EG11090-MONOMER|PMID:11591349|UniProtKB:P0AF12	Source subunit coefficient 2; the protein component is not asserted to independently catalyze the overall reaction.	"[{""reference_id"": ""MetaCyc:CPLX0-1541"", ""source_assertion"": ""The native complex contains 2 copies of EG11090-MONOMER."", ""source_locator"": ""Protein[@frameid='CPLX0-1541']/component/Protein; component/coefficient""}, {""reference_id"": ""MetaCyc:EG11090-MONOMER"", ""source_assertion"": ""EG11090-MONOMER is unified with UniProtKB:P0AF12."", ""source_locator"": ""Protein[@frameid='EG11090-MONOMER']/dblink[dblink-db='UNIPROT']""}, {""reference_id"": ""UniProtKB:P0AF12"", ""source_assertion"": ""The reviewed SUBUNIT annotation describes a homodimer, including ECO:0000269 structural evidence."", ""source_locator"": ""comments[commentType='SUBUNIT']""}, {""reference_id"": ""PMID:11591349"", ""source_assertion"": ""The E. coli nucleosidase structure supports a functional dimer; contacts join the two monomers."", ""source_locator"": ""Europe PMC resultList.result[0].abstractText; structural Results""}]"	"[{""id"": ""MetaCyc:CPLX0-1541"", ""source_sha256"": ""50fe71870869d69b5efd3c628b8a1a451b5d8f5b63d23b6b8e60b1d5a23d1c31"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-1541""}, {""id"": ""MetaCyc:EG11090-MONOMER"", ""source_sha256"": ""27783530814404616097c142617171c5dbe5b394b147d405642b38d92dce3112"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:EG11090-MONOMER""}, {""id"": ""PMID:11591349"", ""source_sha256"": ""f1f417bfbcffe7f7439176df67daa77e197591d42b93f8dd07451468998da32f"", ""source_version"": ""Original article 2001-10-01; inspected Europe PMC core record abstract, not full text"", ""title"": ""Structure of E. coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase reveals similarity to the purine nucleoside phosphorylases."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11591349%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P0AF12"", ""source_sha256"": ""9f22ed9e076eb0ba41aebc4d08df3728b82a38a1efc4381fdcc6a763ae187d48"", ""source_version"": ""2026_03, released 2026-09-02; full JSON"", ""title"": ""UniProtKB reviewed 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF12.json""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-042_8a23b2bbcb87	MetaCyc:S-ADENMETSYN-CPLX	pathwaymech:catalyzes	RHEA:21081	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:S-ADENMETSYN-CPLX|PMID:6251075|RHEA:21080|UniProtKB:P0A817		"[{""reference_id"": ""MetaCyc:S-ADENMETSYN-CPLX"", ""source_assertion"": ""The native complex catalyzes S-ADENMETSYN-RXN."", ""source_locator"": ""Protein[@frameid='S-ADENMETSYN-CPLX']/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:P0A817"", ""source_assertion"": ""The reviewed E. coli K-12 protein has catalytic annotation RHEA:21080; evidence: ECO:0000269 experimental and ECO:0000255 HAMAP."", ""source_locator"": ""organism.taxonId; comments[commentType='CATALYTIC ACTIVITY'].reaction""}, {""reference_id"": ""RHEA:21080"", ""source_assertion"": ""Rhea master 21080 has directed left-to-right reaction 21081."", ""source_locator"": ""http://rdf.rhea-db.org/21080/rh:directionalReaction""}, {""reference_id"": ""PMID:6251075"", ""source_assertion"": ""Purified E. coli adenosylmethionine synthetase performs synthesis and a stimulated tripolyphosphatase reaction."", ""source_locator"": ""Europe PMC resultList.result[0].abstractText""}]"	"[{""id"": ""MetaCyc:S-ADENMETSYN-CPLX"", ""source_sha256"": ""7f904a9c12927ae298b6a61c92374ec46bae8639da53b822521d5cc5ea40f83b"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc methionine adenosyltransferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:S-ADENMETSYN-CPLX""}, {""id"": ""PMID:6251075"", ""source_sha256"": ""8a5faedef736e23b51c0082b4c20e977228113e4228a93e2c4a48c4fbc13900b"", ""source_version"": ""Original article 1980-10-01; inspected Europe PMC core record abstract, not full text"", ""title"": ""S-Adenosylmethionine synthetase from Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6251075%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""RHEA:21080"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21080 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0A817"", ""source_sha256"": ""96b4db3c9596a1e779bbc1d1459e6024981eadaa10ad79a446ee228373293d98"", ""source_version"": ""2026_03, released 2026-09-02; full JSON"", ""title"": ""UniProtKB reviewed S-adenosylmethionine synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A817.json""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-043_d85940ac7dc4	MetaCyc:CPLX0-1541	pathwaymech:catalyzes	RHEA:17806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-1541|PMID:11489131|RHEA:17805|UniProtKB:P0AF12		"[{""reference_id"": ""MetaCyc:CPLX0-1541"", ""source_assertion"": ""The native complex catalyzes ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN."", ""source_locator"": ""Protein[@frameid='CPLX0-1541']/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:P0AF12"", ""source_assertion"": ""The reviewed E. coli K-12 protein has catalytic annotation RHEA:17805; evidence: ECO:0000269 experimental and ECO:0000255 HAMAP."", ""source_locator"": ""organism.taxonId; comments[commentType='CATALYTIC ACTIVITY'].reaction""}, {""reference_id"": ""RHEA:17805"", ""source_assertion"": ""Rhea master 17805 has directed left-to-right reaction 17806."", ""source_locator"": ""http://rdf.rhea-db.org/17805/rh:directionalReaction""}, {""reference_id"": ""PMID:11489131"", ""source_assertion"": ""Purified GST-Pfs from MG1655 removes adenine from SAH, producing SRH before the LuxS step; sequential filtration and mass spectra test this order."", ""source_locator"": ""PDF pp467-468, Table 1 and Fig.4B; p473, Overexpression and purification of LuxS and Pfs""}]"	"[{""id"": ""MetaCyc:CPLX0-1541"", ""source_sha256"": ""50fe71870869d69b5efd3c628b8a1a451b5d8f5b63d23b6b8e60b1d5a23d1c31"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-1541""}, {""id"": ""PMID:11489131"", ""source_sha256"": ""40999a1cf8795969b60ad720b21b22a1e3c8f44fcc47548b4937e07027104ae0"", ""source_version"": ""2001 original published article, author-hosted PDF; inspected Results pp467-471 and Methods pp473-474"", ""title"": ""The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule."", ""url"": ""https://shokatlab.ucsf.edu/pdfs/11489131.pdf""}, {""id"": ""RHEA:17805"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:17805 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0AF12"", ""source_sha256"": ""9f22ed9e076eb0ba41aebc4d08df3728b82a38a1efc4381fdcc6a763ae187d48"", ""source_version"": ""2026_03, released 2026-09-02; full JSON"", ""title"": ""UniProtKB reviewed 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AF12.json""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-044_662d9537e0e8	UniProtKB:P45578	pathwaymech:enables	RHEA:17754	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11489131|RHEA:17753|UniProtKB:P45578	Functional LuxS contribution; its homodimer annotation is by similarity (ECO:0000250). No independently verified E. coli assembly identifier or monomer sufficiency is asserted.	"[{""reference_id"": ""UniProtKB:P45578"", ""source_assertion"": ""The reviewed E. coli K-12 protein has catalytic annotation RHEA:17753; evidence: curated catalytic annotation without a per-reaction evidence tag."", ""source_locator"": ""organism.taxonId; comments[commentType='CATALYTIC ACTIVITY'].reaction""}, {""reference_id"": ""RHEA:17753"", ""source_assertion"": ""Rhea master 17753 has directed left-to-right reaction 17754."", ""source_locator"": ""http://rdf.rhea-db.org/17753/rh:directionalReaction""}, {""reference_id"": ""PMID:11489131"", ""source_assertion"": ""Purified GST-LuxS from MG1655 acts on SRH after Pfs, with homocysteine detected. DPD was inferred to cyclize; this study did not absolutely identify the AI-2 structure."", ""source_locator"": ""PDF pp467-468, Table 1; pp470-471, Discussion; p473, Overexpression and purification""}]"	"[{""id"": ""PMID:11489131"", ""source_sha256"": ""40999a1cf8795969b60ad720b21b22a1e3c8f44fcc47548b4937e07027104ae0"", ""source_version"": ""2001 original published article, author-hosted PDF; inspected Results pp467-471 and Methods pp473-474"", ""title"": ""The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule."", ""url"": ""https://shokatlab.ucsf.edu/pdfs/11489131.pdf""}, {""id"": ""RHEA:17753"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:17753 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P45578"", ""source_sha256"": ""9434d6e2f68eb010e0fa9d916c56e234d582401a4b594f3807e439acbe9716a8"", ""source_version"": ""2026_03, released 2026-09-02; full JSON"", ""title"": ""UniProtKB reviewed S-ribosylhomocysteine lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P45578.json""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-045_921e2f042606	UniProtKB:P25665	pathwaymech:enables	RHEA:21197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HOMOCYSMET-MONOMER|PMID:16618098|RHEA:21196|UniProtKB:P25665	MetE is annotated monomeric; this edge preserves its gene-product activity and separately inspected experimental support without upgrading HAMAP evidence.	"[{""reference_id"": ""UniProtKB:P25665"", ""source_assertion"": ""The reviewed E. coli K-12 protein has catalytic annotation RHEA:21196; evidence: ECO:0000255 HAMAP."", ""source_locator"": ""organism.taxonId; comments[commentType='CATALYTIC ACTIVITY'].reaction""}, {""reference_id"": ""RHEA:21196"", ""source_assertion"": ""Rhea master 21196 has directed left-to-right reaction 21197 and bidirectional reaction 21199."", ""source_locator"": ""http://rdf.rhea-db.org/21196/rh:directionalReaction; rh:bidirectionalReaction""}, {""reference_id"": ""MetaCyc:HOMOCYSMET-MONOMER"", ""source_assertion"": ""The E. coli MetE entry states that it uses triglutamate folate, whereas MetH uses mono- or triglutamate forms; purified K-12 enzyme was characterized."", ""source_locator"": ""Protein[@frameid='HOMOCYSMET-MONOMER']/comment, first three paragraphs""}, {""reference_id"": ""PMID:16618098"", ""source_assertion"": ""MetE transfers a methyl group from methyltetrahydropteroyltriglutamate to homocysteine; substrate-dependent absorbance studies address methyl-donor activation."", ""source_locator"": ""Europe PMC resultList.result[0].abstractText""}]"	"[{""id"": ""MetaCyc:HOMOCYSMET-MONOMER"", ""source_sha256"": ""e7ab420465400e611f97d8c56a48005abe445891bc194b2e51f4929617e33f4d"", ""source_version"": ""MetaCyc 22.5; original XML"", ""title"": ""MetaCyc HOMOCYSMET-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HOMOCYSMET-MONOMER""}, {""id"": ""PMID:16618098"", ""source_sha256"": ""d7041ee61b8f3124e6d259a51e675563647cfab72c9969099d084436c6720ca2"", ""source_version"": ""Original article 2006-04-01; inspected Europe PMC core record abstract, not full text"", ""title"": ""Activation of methyltetrahydrofolate by cobalamin-independent methionine synthase."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=DOI:10.1021/bi060052m&format=json&resultType=core""}, {""id"": ""RHEA:21196"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:21196 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P25665"", ""source_sha256"": ""d7bf2af0c4f7ed0a90872be6b5ba6a677e7ce01a81920f1cc653b2f0b6860140"", ""source_version"": ""2026_03, released 2026-09-02; full JSON"", ""title"": ""UniProtKB reviewed 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P25665.json""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-046_811b2c6fae0d	UniProtKB:P13009	pathwaymech:enables	RHEA:11173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9201956|RHEA:11172|UniProtKB:P13009		"[{""reference_id"": ""UniProtKB:P13009"", ""source_assertion"": ""The reviewed E. coli K-12 protein has catalytic annotation RHEA:11172; evidence: ECO:0000269 experimental."", ""source_locator"": ""organism.taxonId; comments[commentType='CATALYTIC ACTIVITY'].reaction""}, {""reference_id"": ""RHEA:11172"", ""source_assertion"": ""Rhea master 11172 has directed left-to-right reaction 11173."", ""source_locator"": ""http://rdf.rhea-db.org/11172/rh:directionalReaction""}, {""reference_id"": ""PMID:9201956"", ""source_assertion"": ""MetH transfers methyl from bound methylcobalamin to homocysteine and remethylates the cofactor with methyltetrahydrofolate; purified holoenzyme and fragments were investigated."", ""source_locator"": ""Europe PMC resultList.result[0].abstractText""}]"	"[{""id"": ""PMID:9201956"", ""source_sha256"": ""84f6599ca46f49e596eb9e5809cb9389f2c48eddd37d2bd8136fadb16581df98"", ""source_version"": ""Original article 1997-07-01; inspected Europe PMC core record abstract, not full text"", ""title"": ""Cobalamin-dependent methionine synthase is a modular protein with distinct regions for binding homocysteine, methyltetrahydrofolate, cobalamin, and adenosylmethionine."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9201956%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""RHEA:11172"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142, 2026-09-02; SHA256 scope is complete compressed RDF"", ""title"": ""Rhea RHEA:11172 family in complete release RDF"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P13009"", ""source_sha256"": ""7fda950332ad9c9a8604afacbab254e63ce6337b9209c357ca55779ed680d378"", ""source_version"": ""2026_03, released 2026-09-02; full JSON"", ""title"": ""UniProtKB reviewed Methionine synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P13009.json""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-047_7cc17dbadcc2	UniProtKB:P0A817	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:6251075|UniProtKB:P0A817	Mn2+ and Co2+ are tested alternatives to Mg2+, not a requirement that all three divalent metals bind simultaneously; potassium is a separate monovalent cofactor.	"[{""reference_id"": ""UniProtKB:P0A817"", ""source_assertion"": ""The reviewed COFACTOR annotation lists Mg(2+) (CHEBI:18420) with ECO:0000269 evidence; it distinguishes two divalent sites and one potassium site per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors; note""}, {""reference_id"": ""PMID:6251075"", ""source_assertion"": ""Enzymatic activities require a divalent metal; phosphorothioate ATP studies used Mg2+, Mn2+ or Co2+ and indicate metal-nucleotide binding."", ""source_locator"": ""Europe PMC resultList.result[0].abstractText""}]"	"[{""id"": ""PMID:6251075"", ""source_sha256"": ""8a5faedef736e23b51c0082b4c20e977228113e4228a93e2c4a48c4fbc13900b"", ""source_version"": ""Original article 1980-10-01; inspected Europe PMC core record abstract, not full text"", ""title"": ""S-Adenosylmethionine synthetase from Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6251075%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P0A817"", ""source_sha256"": ""96b4db3c9596a1e779bbc1d1459e6024981eadaa10ad79a446ee228373293d98"", ""source_version"": ""2026_03, released 2026-09-02; full JSON"", ""title"": ""UniProtKB reviewed S-adenosylmethionine synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A817.json""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-048_e5a2c3f0832c	UniProtKB:P0A817	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:6251075|UniProtKB:P0A817	Mn2+ and Co2+ are tested alternatives to Mg2+, not a requirement that all three divalent metals bind simultaneously; potassium is a separate monovalent cofactor.	"[{""reference_id"": ""UniProtKB:P0A817"", ""source_assertion"": ""The reviewed COFACTOR annotation lists Mn(2+) (CHEBI:29035) with ECO:0000269 evidence; it distinguishes two divalent sites and one potassium site per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors; note""}, {""reference_id"": ""PMID:6251075"", ""source_assertion"": ""Enzymatic activities require a divalent metal; phosphorothioate ATP studies used Mg2+, Mn2+ or Co2+ and indicate metal-nucleotide binding."", ""source_locator"": ""Europe PMC resultList.result[0].abstractText""}]"	"[{""id"": ""PMID:6251075"", ""source_sha256"": ""8a5faedef736e23b51c0082b4c20e977228113e4228a93e2c4a48c4fbc13900b"", ""source_version"": ""Original article 1980-10-01; inspected Europe PMC core record abstract, not full text"", ""title"": ""S-Adenosylmethionine synthetase from Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6251075%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P0A817"", ""source_sha256"": ""96b4db3c9596a1e779bbc1d1459e6024981eadaa10ad79a446ee228373293d98"", ""source_version"": ""2026_03, released 2026-09-02; full JSON"", ""title"": ""UniProtKB reviewed S-adenosylmethionine synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A817.json""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-049_c4f80d4ef9f4	UniProtKB:P0A817	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:6251075|UniProtKB:P0A817	Mn2+ and Co2+ are tested alternatives to Mg2+, not a requirement that all three divalent metals bind simultaneously; potassium is a separate monovalent cofactor.	"[{""reference_id"": ""UniProtKB:P0A817"", ""source_assertion"": ""The reviewed COFACTOR annotation lists Co(2+) (CHEBI:48828) with ECO:0000269 evidence; it distinguishes two divalent sites and one potassium site per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors; note""}, {""reference_id"": ""PMID:6251075"", ""source_assertion"": ""Enzymatic activities require a divalent metal; phosphorothioate ATP studies used Mg2+, Mn2+ or Co2+ and indicate metal-nucleotide binding."", ""source_locator"": ""Europe PMC resultList.result[0].abstractText""}]"	"[{""id"": ""PMID:6251075"", ""source_sha256"": ""8a5faedef736e23b51c0082b4c20e977228113e4228a93e2c4a48c4fbc13900b"", ""source_version"": ""Original article 1980-10-01; inspected Europe PMC core record abstract, not full text"", ""title"": ""S-Adenosylmethionine synthetase from Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6251075%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P0A817"", ""source_sha256"": ""96b4db3c9596a1e779bbc1d1459e6024981eadaa10ad79a446ee228373293d98"", ""source_version"": ""2026_03, released 2026-09-02; full JSON"", ""title"": ""UniProtKB reviewed S-adenosylmethionine synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A817.json""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-050_de5712a8bc03	UniProtKB:P0A817	pathwaymech:has_cofactor	CHEBI:29103	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A817	Mn2+ and Co2+ are tested alternatives to Mg2+, not a requirement that all three divalent metals bind simultaneously; potassium is a separate monovalent cofactor.	"[{""reference_id"": ""UniProtKB:P0A817"", ""source_assertion"": ""The reviewed COFACTOR annotation lists K(+) (CHEBI:29103) with ECO:0000269 evidence; it distinguishes two divalent sites and one potassium site per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors; note""}]"	"[{""id"": ""UniProtKB:P0A817"", ""source_sha256"": ""96b4db3c9596a1e779bbc1d1459e6024981eadaa10ad79a446ee228373293d98"", ""source_version"": ""2026_03, released 2026-09-02; full JSON"", ""title"": ""UniProtKB reviewed S-adenosylmethionine synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A817.json""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-051_c7e59bc16a20	UniProtKB:P45578	pathwaymech:has_cofactor	CHEBI:24875	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P45578	This is an inferred E. coli annotation at the generic iron-cation level. No exact oxidation state, direct E. coli metal measurement or zinc-independent activity is asserted.	"[{""reference_id"": ""UniProtKB:P45578"", ""source_assertion"": ""UniProt annotates one iron cation per subunit as a cofactor, inferred by similarity (ECO:0000250)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors[0]; note""}]"	"[{""id"": ""UniProtKB:P45578"", ""source_sha256"": ""9434d6e2f68eb010e0fa9d916c56e234d582401a4b594f3807e439acbe9716a8"", ""source_version"": ""2026_03, released 2026-09-02; full JSON"", ""title"": ""UniProtKB reviewed S-ribosylhomocysteine lyase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P45578.json""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-052_5fb9142b4abb	UniProtKB:P25665	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11170420|UniProtKB:P25665		"[{""reference_id"": ""UniProtKB:P25665"", ""source_assertion"": ""The COFACTOR annotation lists zinc(2+), one per subunit, with ECO:0000255 HAMAP evidence."", ""source_locator"": ""comments[commentType='COFACTOR']""}, {""reference_id"": ""PMID:11170420"", ""source_assertion"": ""X-ray absorption studies of E. coli MetE demonstrate coordination of the homocysteine analogue to its zinc site."", ""source_locator"": ""Europe PMC resultList.result[0].abstractText; MetE and L-selenohomocysteine""}]"	"[{""id"": ""PMID:11170420"", ""source_sha256"": ""e0978bb2688c5395955625d4fdecca8c30c3eb1320167bdd27094844a8e348b2"", ""source_version"": ""Original article 2001-01-01; inspected Europe PMC core record abstract, not full text"", ""title"": ""Characterization of the zinc sites in cobalamin-independent and cobalamin-dependent methionine synthase using zinc and selenium X-ray absorption spectroscopy."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11170420%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P25665"", ""source_sha256"": ""d7bf2af0c4f7ed0a90872be6b5ba6a677e7ce01a81920f1cc653b2f0b6860140"", ""source_version"": ""2026_03, released 2026-09-02; full JSON"", ""title"": ""UniProtKB reviewed 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P25665.json""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-053_3dfd4360f0e2	UniProtKB:P13009	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9398304|UniProtKB:P13009		"[{""reference_id"": ""UniProtKB:P13009"", ""source_assertion"": ""The COFACTOR annotation lists zinc(2+), one per subunit, with ECO:0000269 evidence."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors; note""}, {""reference_id"": ""PMID:9398304"", ""source_assertion"": ""E. coli MetH zinc removal abolished methyl transfer; reconstitution partly restored activity. Holoenzyme and a truncated protein contained about 0.9 equivalents of zinc."", ""source_locator"": ""Europe PMC resultList.result[0].abstractText""}]"	"[{""id"": ""PMID:9398304"", ""source_sha256"": ""7d845ba91c571246f9961cba75cd53c818e60dc397d880c2d01f8fb8c3d2f646"", ""source_version"": ""Original article 1997-12-01; inspected Europe PMC core record abstract, not full text"", ""title"": ""Cobalamin-dependent methionine synthase from Escherichia coli: involvement of zinc in homocysteine activation."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9398304%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P13009"", ""source_sha256"": ""7fda950332ad9c9a8604afacbab254e63ce6337b9209c357ca55779ed680d378"", ""source_version"": ""2026_03, released 2026-09-02; full JSON"", ""title"": ""UniProtKB reviewed Methionine synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P13009.json""}]"	""
pathwaymech:MetaCyc_PWY-6151_sam-cycle-edge-054_8fa697374e3e	UniProtKB:P13009	pathwaymech:has_cofactor	CHEBI:28115	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:9201956|UniProtKB:P13009	Cobalamin cycling is internal to the net methionine-synthase equation. Reductive reactivation is not added as a second methyl-transfer step of the native cycle.	"[{""reference_id"": ""UniProtKB:P13009"", ""source_assertion"": ""UniProt lists methylcob(III)alamin as the cofactor with ECO:0000269 evidence."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors[cofactorCrossReference.id='CHEBI:28115']""}, {""reference_id"": ""PMID:9201956"", ""source_assertion"": ""The bound methylcobalamin transfers methyl to homocysteine; methyltetrahydrofolate then remethylates the bound cob(I)alamin."", ""source_locator"": ""Europe PMC resultList.result[0].abstractText""}]"	"[{""id"": ""PMID:9201956"", ""source_sha256"": ""84f6599ca46f49e596eb9e5809cb9389f2c48eddd37d2bd8136fadb16581df98"", ""source_version"": ""Original article 1997-07-01; inspected Europe PMC core record abstract, not full text"", ""title"": ""Cobalamin-dependent methionine synthase is a modular protein with distinct regions for binding homocysteine, methyltetrahydrofolate, cobalamin, and adenosylmethionine."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9201956%20AND%20SRC:MED&format=json&resultType=core""}, {""id"": ""UniProtKB:P13009"", ""source_sha256"": ""7fda950332ad9c9a8604afacbab254e63ce6337b9209c357ca55779ed680d378"", ""source_version"": ""2026_03, released 2026-09-02; full JSON"", ""title"": ""UniProtKB reviewed Methionine synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P13009.json""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-001_813b7816ae1f	gomodel:S-ADENMETSYN-RXN	RO:0002234	CHEBI:59789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:S-ADENMETSYN-RXN RO:0002234 gomodel:CHEBI_59789_S-ADENMETSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/0; endpoint types: /individuals/17/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-002_73fb751976c9	gomodel:YeastPathways_PWY-5041/6a2b236300005409	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5041/6a2b236300005409 BFO:0000066 gomodel:YeastPathways_PWY-5041/6a2b236300005416."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/1; endpoint types: /individuals/53/type; /individuals/59/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-003_6f1eb9be0a72	gomodel:YeastPathways_PWY-5041/6a2b236300005409	RO:0002234	CHEBI:59789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5041/6a2b236300005409 RO:0002234 gomodel:CHEBI_59789_S-ADENMETSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/2; endpoint types: /individuals/53/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-004_4aeed9d6a5bb	gomodel:S-ADENMETSYN-RXN	BFO:0000050	GO:0033353	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:S-ADENMETSYN-RXN BFO:0000050 gomodel:YeastPathways_PWY-5041/YeastPathways_PWY-5041."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/3; endpoint types: /individuals/17/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-005_c1e24446598e	gomodel:YeastPathways_PWY-5041/6a2b236300005409	BFO:0000050	GO:0033353	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5041/6a2b236300005409 BFO:0000050 gomodel:YeastPathways_PWY-5041/YeastPathways_PWY-5041."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/4; endpoint types: /individuals/53/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-006_d67ad45d9b55	gomodel:YeastPathways_PWY-5041/6a2b236300005409	RO:0002233	CHEBI:57844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5041/6a2b236300005409 RO:0002233 gomodel:CHEBI_57844_HOMOCYSMET-RXN."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/5; endpoint types: /individuals/53/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-007_4f855f2fc40d	gomodel:S-ADENMETSYN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:S-ADENMETSYN-RXN RO:0002233 gomodel:CHEBI_30616_S-ADENMETSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/6; endpoint types: /individuals/17/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-008_3efec66886af	gomodel:ADENOSYLHOMOCYSTEINASE-RXN	RO:0002234	CHEBI:16335	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:ADENOSYLHOMOCYSTEINASE-RXN RO:0002234 gomodel:CHEBI_16335_ADENOSYLHOMOCYSTEINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/7; endpoint types: /individuals/0/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-009_81f7d90d029c	SGD:S000000893	pathwaymech:enables	gomodel:HOMOCYSMET-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:HOMOCYSMET-RXN RO:0002333 gomodel:YER091C-MONOMER_HOMOCYSMET-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/8; endpoint types: /individuals/15/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-010_2c54762c1bae	SGD:S000004170	pathwaymech:enables	gomodel:S-ADENMETSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:S-ADENMETSYN-RXN RO:0002333 gomodel:YLR180W-MONOMER_S-ADENMETSYN-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/9; endpoint types: /individuals/17/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-011_e5939bbeff9b	gomodel:RXN-7605	RO:0002234	CHEBI:57856	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:RXN-7605 RO:0002234 gomodel:CHEBI_57856_RXN-7605."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/10; endpoint types: /individuals/16/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-012_46553c16cde5	gomodel:HOMOCYSMET-RXN	BFO:0000050	GO:0033353	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:HOMOCYSMET-RXN BFO:0000050 gomodel:YeastPathways_PWY-5041/YeastPathways_PWY-5041."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/11; endpoint types: /individuals/15/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-013_50dd73a46f56	gomodel:S-ADENMETSYN-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:S-ADENMETSYN-RXN RO:0002233 gomodel:CHEBI_15377_S-ADENMETSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/12; endpoint types: /individuals/17/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-014_2ee193f062c3	gomodel:YeastPathways_PWY-5041/6a2b236300005409	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5041/6a2b236300005409 RO:0002234 gomodel:YeastPathways_PWY-5041/6a2b236300005413."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/13; endpoint types: /individuals/53/type; /individuals/57/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-015_2e1cfe7ee475	gomodel:YeastPathways_PWY-5041/6a2b236300005409	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5041/6a2b236300005409 RO:0002234 gomodel:YeastPathways_PWY-5041/6a2b236300005412."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/14; endpoint types: /individuals/53/type; /individuals/56/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-016_26af3aa325ee	gomodel:S-ADENMETSYN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:S-ADENMETSYN-RXN BFO:0000066 gomodel:reaction_S-ADENMETSYN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/15; endpoint types: /individuals/17/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-017_e52a94cad435	gomodel:S-ADENMETSYN-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:S-ADENMETSYN-RXN RO:0002234 gomodel:CHEBI_29888_S-ADENMETSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/16; endpoint types: /individuals/17/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-018_a45557a7f0ee	gomodel:HOMOCYSMET-RXN	RO:0002233	CHEBI:58199	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:HOMOCYSMET-RXN RO:0002233 gomodel:CHEBI_58199_ADENOSYLHOMOCYSTEINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/17; endpoint types: /individuals/15/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-019_7eca8dae6aab	gomodel:RXN-7605	RO:0002233	CHEBI:142491	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:RXN-7605 RO:0002233 gomodel:CHEBI_142491_RXN-7605."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/18; endpoint types: /individuals/16/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-020_167890b38f6e	gomodel:RXN-7605	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:RXN-7605 RO:0002234 gomodel:CHEBI_15378_RXN-7605."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/19; endpoint types: /individuals/16/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-021_6f85754f44cb	gomodel:RXN-7605	BFO:0000050	GO:0033353	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:RXN-7605 BFO:0000050 gomodel:YeastPathways_PWY-5041/YeastPathways_PWY-5041."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/20; endpoint types: /individuals/16/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-022_ebbb7d6243ba	gomodel:RXN-7605	RO:0002234	gomodel:ba4cc2f6-35b0-45f1-a3b5-7bf7a1e71bf8_RXN-7605	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:RXN-7605 RO:0002234 gomodel:ba4cc2f6-35b0-45f1-a3b5-7bf7a1e71bf8_RXN-7605."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/21; endpoint types: /individuals/16/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-023_de3f1117113d	gomodel:S-ADENMETSYN-RXN	RO:0002233	CHEBI:57844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:S-ADENMETSYN-RXN RO:0002233 gomodel:CHEBI_57844_HOMOCYSMET-RXN."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/22; endpoint types: /individuals/17/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-024_e8c181b41b9a	gomodel:ADENOSYLHOMOCYSTEINASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:ADENOSYLHOMOCYSTEINASE-RXN BFO:0000066 gomodel:reaction_ADENOSYLHOMOCYSTEINASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/23; endpoint types: /individuals/0/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-025_2d30d28ded83	gomodel:RXN-7605	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:RXN-7605 BFO:0000066 gomodel:reaction_RXN-7605_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/24; endpoint types: /individuals/16/type; /individuals/50/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-026_2419da6795fc	gomodel:HOMOCYSMET-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:HOMOCYSMET-RXN BFO:0000066 gomodel:reaction_HOMOCYSMET-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/25; endpoint types: /individuals/15/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-027_d21daa2e2df6	gomodel:YeastPathways_PWY-5041/6a2b236300005409	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5041/6a2b236300005409 RO:0002233 gomodel:YeastPathways_PWY-5041/6a2b236300005411."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/26; endpoint types: /individuals/53/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-028_16f0b493e7a4	gomodel:YeastPathways_PWY-5041/6a2b236300005409	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5041/6a2b236300005409 RO:0002233 gomodel:YeastPathways_PWY-5041/6a2b236300005410."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/27; endpoint types: /individuals/53/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-029_df55ce11bce6	gomodel:ADENOSYLHOMOCYSTEINASE-RXN	RO:0002233	CHEBI:57856	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:ADENOSYLHOMOCYSTEINASE-RXN RO:0002233 gomodel:CHEBI_57856_RXN-7605."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/28; endpoint types: /individuals/0/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-030_d559b8ce696f	gomodel:RXN-7605	RO:0002233	CHEBI:59789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:RXN-7605 RO:0002233 gomodel:CHEBI_59789_S-ADENMETSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/29; endpoint types: /individuals/16/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-031_94cfd89e7c18	gomodel:ADENOSYLHOMOCYSTEINASE-RXN	RO:0002234	CHEBI:58199	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:ADENOSYLHOMOCYSTEINASE-RXN RO:0002234 gomodel:CHEBI_58199_ADENOSYLHOMOCYSTEINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/30; endpoint types: /individuals/0/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-032_19b8b7881807	gomodel:HOMOCYSMET-RXN	RO:0002234	CHEBI:57844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:HOMOCYSMET-RXN RO:0002234 gomodel:CHEBI_57844_HOMOCYSMET-RXN."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/31; endpoint types: /individuals/15/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-033_262906b50051	gomodel:HOMOCYSMET-RXN	RO:0002233	CHEBI:58207	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:HOMOCYSMET-RXN RO:0002233 gomodel:CHEBI_58207_HOMOCYSMET-RXN."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/32; endpoint types: /individuals/15/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-034_98065ed9c153	SGD:S000000845	pathwaymech:enables	gomodel:ADENOSYLHOMOCYSTEINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:ADENOSYLHOMOCYSTEINASE-RXN RO:0002333 gomodel:YER043C-MONOMER_ADENOSYLHOMOCYSTEINASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/33; endpoint types: /individuals/0/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-035_07d5b90cb831	gomodel:ADENOSYLHOMOCYSTEINASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:ADENOSYLHOMOCYSTEINASE-RXN RO:0002233 gomodel:CHEBI_15377_ADENOSYLHOMOCYSTEINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/34; endpoint types: /individuals/0/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-036_16044b256e4a	SGD:S000002910	pathwaymech:enables	gomodel:YeastPathways_PWY-5041/6a2b236300005409	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5041/6a2b236300005409 RO:0002333 gomodel:YeastPathways_PWY-5041/6a2b236300005415."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/35; endpoint types: /individuals/53/type; /individuals/58/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-037_9f9fed0ffc46	gomodel:ADENOSYLHOMOCYSTEINASE-RXN	BFO:0000050	GO:0033353	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:ADENOSYLHOMOCYSTEINASE-RXN BFO:0000050 gomodel:YeastPathways_PWY-5041/YeastPathways_PWY-5041."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/36; endpoint types: /individuals/0/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-038_4c20e05fbd75	gomodel:HOMOCYSMET-RXN	RO:0002234	CHEBI:58140	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:HOMOCYSMET-RXN RO:0002234 gomodel:CHEBI_58140_HOMOCYSMET-RXN."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/37; endpoint types: /individuals/15/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_edge-039_94deefca51b1	gomodel:S-ADENMETSYN-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5041		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5041"", ""source_assertion"": ""The model asserts gomodel:S-ADENMETSYN-RXN RO:0002234 gomodel:CHEBI_43474_S-ADENMETSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5041.json#/facts/38; endpoint types: /individuals/17/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5041"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5041.json"", ""title"": ""GO-CAM S-adenosyl-L-methionine cycle II model YeastPathways_PWY-5041"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_cofactor-31a055859ea5_0dcd4310c9a1	SGD:S000000893	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05694	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P05694"", ""source_assertion"": ""UniProtKB:P05694 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3234/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P05694"", ""source_assertion"": ""UniProtKB:P05694 has the exact SGD cross-reference SGD:S000000893."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3234/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P05694"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P05694 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_cofactor-fe984036de0f_ed817dbf05dd	SGD:S000004170	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10659	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P13444) Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate. UniProt note evidence: ECO:0000250 (UniProtKB:P13444)	"[{""reference_id"": ""UniProtKB:P10659"", ""source_assertion"": ""UniProtKB:P10659 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/310/comments/0/cofactors/0; /results/310/comments/0/note""}, {""reference_id"": ""UniProtKB:P10659"", ""source_assertion"": ""UniProtKB:P10659 has the exact SGD cross-reference SGD:S000004170."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/310/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P10659"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P10659 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_cofactor-b1e8d3e04819_3f02aaca2806	SGD:S000004170	pathwaymech:has_cofactor	CHEBI:29103	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10659	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P13444) Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate. UniProt note evidence: ECO:0000250 (UniProtKB:P13444)	"[{""reference_id"": ""UniProtKB:P10659"", ""source_assertion"": ""UniProtKB:P10659 annotates CHEBI:29103 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/310/comments/1/cofactors/0; /results/310/comments/1/note""}, {""reference_id"": ""UniProtKB:P10659"", ""source_assertion"": ""UniProtKB:P10659 has the exact SGD cross-reference SGD:S000004170."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/310/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P10659"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P10659 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_cofactor-70a779ec4bd1_91a3b6e900e0	SGD:S000000845	pathwaymech:has_cofactor	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39954	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified Binds 1 NAD(+) per subunit.	"[{""reference_id"": ""UniProtKB:P39954"", ""source_assertion"": ""UniProtKB:P39954 annotates CHEBI:57540 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3692/comments/0/cofactors/0; /results/3692/comments/0/note""}, {""reference_id"": ""UniProtKB:P39954"", ""source_assertion"": ""UniProtKB:P39954 has the exact SGD cross-reference SGD:S000000845."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3692/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P39954"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P39954 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_cofactor-415b482f5e06_6ed805d780e6	SGD:S000002910	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P19358	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P13444) Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate. UniProt note evidence: ECO:0000250 (UniProtKB:P13444)	"[{""reference_id"": ""UniProtKB:P19358"", ""source_assertion"": ""UniProtKB:P19358 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/496/comments/0/cofactors/0; /results/496/comments/0/note""}, {""reference_id"": ""UniProtKB:P19358"", ""source_assertion"": ""UniProtKB:P19358 has the exact SGD cross-reference SGD:S000002910."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/496/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P19358"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P19358 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5041_cofactor-402dbb6ac4b9_77f7909e2585	SGD:S000002910	pathwaymech:has_cofactor	CHEBI:29103	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P19358	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P13444) Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate. UniProt note evidence: ECO:0000250 (UniProtKB:P13444)	"[{""reference_id"": ""UniProtKB:P19358"", ""source_assertion"": ""UniProtKB:P19358 annotates CHEBI:29103 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/496/comments/1/cofactors/0; /results/496/comments/1/note""}, {""reference_id"": ""UniProtKB:P19358"", ""source_assertion"": ""UniProtKB:P19358 has the exact SGD cross-reference SGD:S000002910."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/496/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P19358"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P19358 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-001_6d46fca8e407	gomodel:URACIL-PRIBOSYLTRANS-RXN	RO:0002233	CHEBI:17568	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URACIL-PRIBOSYLTRANS-RXN RO:0002233 gomodel:CHEBI_17568_URIDINE-NUCLEOSIDASE-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/0; endpoint types: /individuals/40/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-002_3337ac14c971	gomodel:URIDINE-NUCLEOSIDASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URIDINE-NUCLEOSIDASE-RXN RO:0002233 gomodel:CHEBI_15377_URIDINE-NUCLEOSIDASE-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/1; endpoint types: /individuals/41/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-003_ff726705ee96	gomodel:URACIL-PRIBOSYLTRANS-RXN	BFO:0000050	GO:0010138	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URACIL-PRIBOSYLTRANS-RXN BFO:0000050 gomodel:YeastPathways_YEAST-RNT-SALV/YeastPathways_YEAST-RNT-SALV."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/2; endpoint types: /individuals/40/type; /individuals/119/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-004_b430dc9cd7e0	gomodel:CYTDEAM-RXN	BFO:0000050	GO:0010138	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTDEAM-RXN BFO:0000050 gomodel:YeastPathways_YEAST-RNT-SALV/YeastPathways_YEAST-RNT-SALV."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/3; endpoint types: /individuals/35/type; /individuals/119/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-005_14995f52e54b	gomodel:RXN0-361	RO:0002234	CHEBI:16040	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:RXN0-361 RO:0002234 gomodel:CHEBI_16040_RXN0-361."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/4; endpoint types: /individuals/39/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-006_e8f65afc506c	gomodel:URACIL-PRIBOSYLTRANS-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URACIL-PRIBOSYLTRANS-RXN BFO:0000066 gomodel:reaction_URACIL-PRIBOSYLTRANS-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/5; endpoint types: /individuals/40/type; /individuals/116/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-007_d3acb4f12c6c	gomodel:RXN-11832	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:RXN-11832 RO:0002234 gomodel:CHEBI_456216_RXN-11832."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/6; endpoint types: /individuals/38/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-008_dd027e96284a	gomodel:CYTDEAM-RXN	RO:0002233	CHEBI:16040	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTDEAM-RXN RO:0002233 gomodel:CHEBI_16040_RXN0-361."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/7; endpoint types: /individuals/35/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-009_5d4c9f4bb97a	gomodel:RXN-11832	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:RXN-11832 BFO:0000066 gomodel:reaction_RXN-11832_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/8; endpoint types: /individuals/38/type; /individuals/114/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-010_85e10786d441	gomodel:CYTDEAM-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTDEAM-RXN RO:0002233 gomodel:CHEBI_15378_CYTDEAM-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/9; endpoint types: /individuals/35/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-011_18abeea2a175	gomodel:CYTDEAM-RXN	RO:0002234	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTDEAM-RXN RO:0002234 gomodel:CHEBI_28938_CYTDEAM-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/10; endpoint types: /individuals/35/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-012_e46939db0964	gomodel:URIDINEKIN-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URIDINEKIN-RXN RO:0002234 gomodel:CHEBI_456216_URIDINEKIN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/11; endpoint types: /individuals/42/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-013_7793f4b7582c	gomodel:RXN0-361	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:RXN0-361 BFO:0000066 gomodel:reaction_RXN0-361_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/12; endpoint types: /individuals/39/type; /individuals/115/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-014_501f780d1bd0	gomodel:CDPKIN-RXN	BFO:0000050	GO:0010138	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CDPKIN-RXN BFO:0000050 gomodel:YeastPathways_YEAST-RNT-SALV/YeastPathways_YEAST-RNT-SALV."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/13; endpoint types: /individuals/0/type; /individuals/119/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-015_dd5ce893d3a5	gomodel:URIDINE-NUCLEOSIDASE-RXN	RO:0002234	CHEBI:47013	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URIDINE-NUCLEOSIDASE-RXN RO:0002234 gomodel:CHEBI_47013_URIDINE-NUCLEOSIDASE-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/14; endpoint types: /individuals/41/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-016_3c11d0ef26ae	gomodel:URIDINE-NUCLEOSIDASE-RXN	RO:0002233	CHEBI:16704	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URIDINE-NUCLEOSIDASE-RXN RO:0002233 gomodel:CHEBI_16704_CYTIDEAM2-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/15; endpoint types: /individuals/41/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-017_2251721e282e	gomodel:RXN0-361	RO:0002234	CHEBI:47013	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:RXN0-361 RO:0002234 gomodel:CHEBI_47013_RXN0-361."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/16; endpoint types: /individuals/39/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-018_af0b46f3fccd	gomodel:URIDINEKIN-RXN	BFO:0000050	GO:0010138	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URIDINEKIN-RXN BFO:0000050 gomodel:YeastPathways_YEAST-RNT-SALV/YeastPathways_YEAST-RNT-SALV."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/17; endpoint types: /individuals/42/type; /individuals/119/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-019_14a56365b0df	gomodel:CYTIDINEKIN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTIDINEKIN-RXN BFO:0000066 gomodel:reaction_CYTIDINEKIN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/18; endpoint types: /individuals/37/type; /individuals/113/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-020_b6488a48ddd1	SGD:S000002808	pathwaymech:enables	gomodel:URIDINE-NUCLEOSIDASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URIDINE-NUCLEOSIDASE-RXN RO:0002333 gomodel:YDR400W-MONOMER_URIDINE-NUCLEOSIDASE-RXN_controller."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/19; endpoint types: /individuals/41/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-021_e660b3f45c33	gomodel:CYTDEAM-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTDEAM-RXN RO:0002233 gomodel:CHEBI_15377_CYTDEAM-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/20; endpoint types: /individuals/35/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-022_14e65c1553d1	gomodel:URIDINEKIN-RXN	RO:0002233	CHEBI:16704	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URIDINEKIN-RXN RO:0002233 gomodel:CHEBI_16704_CYTIDEAM2-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/21; endpoint types: /individuals/42/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-023_04b93db70994	SGD:S000002808	pathwaymech:enables	gomodel:RXN0-361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:RXN0-361 RO:0002333 gomodel:YDR400W-MONOMER_RXN0-361_controller."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/22; endpoint types: /individuals/39/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-024_73c03e840307	gomodel:CDPKIN-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CDPKIN-RXN RO:0002234 gomodel:CHEBI_456216_CDPKIN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/23; endpoint types: /individuals/0/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-025_07b4b3b53320	SGD:S000005295	pathwaymech:enables	gomodel:CYTIDINEKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTIDINEKIN-RXN RO:0002333 gomodel:YNR012W-MONOMER_CYTIDINEKIN-RXN_controller."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/24; endpoint types: /individuals/37/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-026_ec81fabb010b	gomodel:CYTIDINEKIN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTIDINEKIN-RXN RO:0002234 gomodel:CHEBI_15378_CYTIDINEKIN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/25; endpoint types: /individuals/37/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-027_4b151cbf9c91	gomodel:CYTIDINEKIN-RXN	RO:0002233	CHEBI:37565	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTIDINEKIN-RXN RO:0002233 gomodel:CHEBI_37565_CYTIDINEKIN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/26; endpoint types: /individuals/37/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-028_679dab205a23	gomodel:URACIL-PRIBOSYLTRANS-RXN	RO:0002233	CHEBI:58017	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URACIL-PRIBOSYLTRANS-RXN RO:0002233 gomodel:CHEBI_58017_URACIL-PRIBOSYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/27; endpoint types: /individuals/40/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-029_7c18e9d00d78	gomodel:CYTIDINEKIN-RXN	RO:0002234	CHEBI:58189	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTIDINEKIN-RXN RO:0002234 gomodel:CHEBI_58189_CYTIDINEKIN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/28; endpoint types: /individuals/37/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-030_d9c91dae476c	gomodel:RXN0-361	RO:0002233	CHEBI:17562	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:RXN0-361 RO:0002233 gomodel:CHEBI_17562_RXN0-361."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/29; endpoint types: /individuals/39/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-031_491e31b73849	gomodel:URIDINEKIN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URIDINEKIN-RXN BFO:0000066 gomodel:reaction_URIDINEKIN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/30; endpoint types: /individuals/42/type; /individuals/118/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-032_9b620b0a8140	SGD:S000001550	pathwaymech:enables	gomodel:CDPKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CDPKIN-RXN RO:0002333 gomodel:YKL067W-MONOMER_CDPKIN-RXN_controller."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/31; endpoint types: /individuals/0/type; /individuals/47/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-033_a837f80eb143	gomodel:RXN-11832	RO:0002234	CHEBI:58069	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:RXN-11832 RO:0002234 gomodel:CHEBI_58069_RXN-11832."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/32; endpoint types: /individuals/38/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-034_9a8501e7677c	gomodel:RXN0-361	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:RXN0-361 RO:0002233 gomodel:CHEBI_15377_RXN0-361."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/33; endpoint types: /individuals/39/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-035_1a821f7bfd0e	gomodel:CYTIDEAM2-RXN	RO:0002234	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTIDEAM2-RXN RO:0002234 gomodel:CHEBI_28938_CYTIDEAM2-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/34; endpoint types: /individuals/36/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-036_882a0882c43e	gomodel:RXN0-361	BFO:0000050	GO:0010138	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:RXN0-361 BFO:0000050 gomodel:YeastPathways_YEAST-RNT-SALV/YeastPathways_YEAST-RNT-SALV."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/35; endpoint types: /individuals/39/type; /individuals/119/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-037_36aa515b8374	gomodel:CYTIDINEKIN-RXN	RO:0002234	CHEBI:60377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTIDINEKIN-RXN RO:0002234 gomodel:CHEBI_60377_CYTIDINEKIN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/36; endpoint types: /individuals/37/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-038_83c45ec10c56	gomodel:URIDINE-NUCLEOSIDASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URIDINE-NUCLEOSIDASE-RXN BFO:0000066 gomodel:reaction_URIDINE-NUCLEOSIDASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/37; endpoint types: /individuals/41/type; /individuals/117/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-039_d2c8dcc282b7	gomodel:RXN-11832	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:RXN-11832 RO:0002233 gomodel:CHEBI_30616_RXN-11832."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/38; endpoint types: /individuals/38/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-040_006b15f1564a	gomodel:CYTDEAM-RXN	RO:0002234	CHEBI:17568	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTDEAM-RXN RO:0002234 gomodel:CHEBI_17568_CYTDEAM-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/39; endpoint types: /individuals/35/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-041_2390d1a86646	gomodel:CYTIDEAM2-RXN	BFO:0000050	GO:0010138	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTIDEAM2-RXN BFO:0000050 gomodel:YeastPathways_YEAST-RNT-SALV/YeastPathways_YEAST-RNT-SALV."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/40; endpoint types: /individuals/36/type; /individuals/119/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-042_86e2b722e004	gomodel:CYTIDEAM2-RXN	RO:0002234	CHEBI:16704	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTIDEAM2-RXN RO:0002234 gomodel:CHEBI_16704_CYTIDEAM2-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/41; endpoint types: /individuals/36/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-043_59129275597c	gomodel:CDPKIN-RXN	RO:0002233	CHEBI:58069	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CDPKIN-RXN RO:0002233 gomodel:CHEBI_58069_RXN-11832."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/42; endpoint types: /individuals/0/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-044_57b3b190df8f	gomodel:RXN-11832	RO:0002233	CHEBI:60377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:RXN-11832 RO:0002233 gomodel:CHEBI_60377_CYTIDINEKIN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/43; endpoint types: /individuals/38/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-045_016d84466363	gomodel:CYTIDINEKIN-RXN	BFO:0000050	GO:0010138	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTIDINEKIN-RXN BFO:0000050 gomodel:YeastPathways_YEAST-RNT-SALV/YeastPathways_YEAST-RNT-SALV."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/44; endpoint types: /individuals/37/type; /individuals/119/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-046_8417af540731	gomodel:CYTIDEAM2-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTIDEAM2-RXN RO:0002233 gomodel:CHEBI_15378_CYTIDEAM2-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/45; endpoint types: /individuals/36/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-047_c195cdd0c218	SGD:S000001507	pathwaymech:enables	gomodel:RXN-11832	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15700|gomodel:YeastPathways_YEAST-RNT-SALV	URA6-mediated CMP phosphorylation is disputed: UniProt's CAUTION reports positive results in PMID:1333436/Ref.8 and negative results in PMID:2172245/8391780. Retain the native branch as a qualified biochemical possibility, not an established physiological substrate assignment.	"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:RXN-11832 RO:0002333 gomodel:YKL024C-MONOMER_RXN-11832_controller."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/46; endpoint types: /individuals/38/type; /individuals/46/type""}, {""reference_id"": ""UniProtKB:P15700"", ""source_assertion"": ""URA6-mediated CMP phosphorylation is disputed: UniProt's CAUTION reports positive results in PMID:1333436/Ref.8 and negative results in PMID:2172245/8391780. Retain the native branch as a qualified biochemical possibility, not an established physiological substrate assignment."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/P15700.json [sha256:0558d409b3620b20cc57c77b6e3cf019b4606d9c0402d6568ceb0e6440aa4385] #/comments/9/texts/0""}]"	"[{""id"": ""UniProtKB:P15700"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P15700 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}, {""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-048_df51d8c26f2b	SGD:S000006266	pathwaymech:enables	gomodel:CYTDEAM-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTDEAM-RXN RO:0002333 gomodel:YPR062W-MONOMER_CYTDEAM-RXN_controller."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/47; endpoint types: /individuals/35/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-049_c7f113513e37	gomodel:URIDINEKIN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URIDINEKIN-RXN RO:0002233 gomodel:CHEBI_30616_URIDINEKIN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/48; endpoint types: /individuals/42/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-050_8af025949ef3	gomodel:CYTIDEAM2-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTIDEAM2-RXN RO:0002233 gomodel:CHEBI_15377_CYTIDEAM2-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/49; endpoint types: /individuals/36/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-051_618b48bff8dc	gomodel:CYTIDEAM2-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTIDEAM2-RXN BFO:0000066 gomodel:reaction_CYTIDEAM2-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/50; endpoint types: /individuals/36/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-052_5526491bb054	gomodel:CYTDEAM-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTDEAM-RXN BFO:0000066 gomodel:reaction_CYTDEAM-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/51; endpoint types: /individuals/35/type; /individuals/111/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-053_471bab442301	SGD:S000004235	pathwaymech:enables	gomodel:CYTIDEAM2-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTIDEAM2-RXN RO:0002333 gomodel:YLR245C-MONOMER_CYTIDEAM2-RXN_controller."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/52; endpoint types: /individuals/36/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-054_88e1d32d9ad2	gomodel:CDPKIN-RXN	RO:0002234	CHEBI:37563	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CDPKIN-RXN RO:0002234 gomodel:CHEBI_37563_CDPKIN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/53; endpoint types: /individuals/0/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-055_026af12832cf	gomodel:CYTIDINEKIN-RXN	RO:0002233	CHEBI:17562	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTIDINEKIN-RXN RO:0002233 gomodel:CHEBI_17562_CYTIDINEKIN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/54; endpoint types: /individuals/37/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-056_68c417a99da9	gomodel:CDPKIN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CDPKIN-RXN RO:0002233 gomodel:CHEBI_30616_CDPKIN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/55; endpoint types: /individuals/0/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-057_7f461bab0482	SGD:S000005295	pathwaymech:enables	gomodel:URIDINEKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URIDINEKIN-RXN RO:0002333 gomodel:YNR012W-MONOMER_URIDINEKIN-RXN_controller."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/56; endpoint types: /individuals/42/type; /individuals/50/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-058_8c3e82a916a1	gomodel:URIDINE-NUCLEOSIDASE-RXN	RO:0002234	CHEBI:17568	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URIDINE-NUCLEOSIDASE-RXN RO:0002234 gomodel:CHEBI_17568_URIDINE-NUCLEOSIDASE-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/57; endpoint types: /individuals/41/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-059_b8d33492c9d2	gomodel:RXN-11832	BFO:0000050	GO:0010138	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:RXN-11832 BFO:0000050 gomodel:YeastPathways_YEAST-RNT-SALV/YeastPathways_YEAST-RNT-SALV."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/58; endpoint types: /individuals/38/type; /individuals/119/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-060_15330b22a7eb	gomodel:URIDINEKIN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URIDINEKIN-RXN RO:0002234 gomodel:CHEBI_15378_URIDINEKIN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/59; endpoint types: /individuals/42/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-061_636b04c6c024	gomodel:URACIL-PRIBOSYLTRANS-RXN	RO:0002234	CHEBI:57865	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URACIL-PRIBOSYLTRANS-RXN RO:0002234 gomodel:CHEBI_57865_URACIL-PRIBOSYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/60; endpoint types: /individuals/40/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-062_e3e35aaff705	gomodel:URIDINE-NUCLEOSIDASE-RXN	BFO:0000050	GO:0010138	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URIDINE-NUCLEOSIDASE-RXN BFO:0000050 gomodel:YeastPathways_YEAST-RNT-SALV/YeastPathways_YEAST-RNT-SALV."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/61; endpoint types: /individuals/41/type; /individuals/119/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-063_4fea7f763ec9	gomodel:URACIL-PRIBOSYLTRANS-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URACIL-PRIBOSYLTRANS-RXN RO:0002234 gomodel:CHEBI_29888_URACIL-PRIBOSYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/62; endpoint types: /individuals/40/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-064_154206ba4f26	gomodel:CDPKIN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CDPKIN-RXN BFO:0000066 gomodel:reaction_CDPKIN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/63; endpoint types: /individuals/0/type; /individuals/110/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-065_b615bb386593	gomodel:CYTIDEAM2-RXN	RO:0002233	CHEBI:17562	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:CYTIDEAM2-RXN RO:0002233 gomodel:CHEBI_17562_CYTIDEAM2-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/64; endpoint types: /individuals/36/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-066_c2ab94a109cf	SGD:S000001170	pathwaymech:enables	gomodel:URACIL-PRIBOSYLTRANS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URACIL-PRIBOSYLTRANS-RXN RO:0002333 gomodel:YHR128W-MONOMER_URACIL-PRIBOSYLTRANS-RXN_controller."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/65; endpoint types: /individuals/40/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_edge-067_d80d93ecaf47	gomodel:URIDINEKIN-RXN	RO:0002234	CHEBI:57865	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_YEAST-RNT-SALV		"[{""reference_id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_assertion"": ""The model asserts gomodel:URIDINEKIN-RXN RO:0002234 gomodel:CHEBI_57865_URIDINEKIN-RXN."", ""source_locator"": ""./YeastPathways_YEAST-RNT-SALV.json#/facts/66; endpoint types: /individuals/42/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_YEAST-RNT-SALV"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json"", ""title"": ""SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_location-d8bf08caac5d_b813e8752e90	SGD:S000002808	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q04179	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q04179"", ""source_assertion"": ""UniProtKB:Q04179 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2585/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q04179"", ""source_assertion"": ""UniProtKB:Q04179 has the exact SGD cross-reference SGD:S000002808."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2585/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q04179"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q04179 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_location-67a269c152c6_f95f15c17021	SGD:S000002808	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q04179	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q04179"", ""source_assertion"": ""UniProtKB:Q04179 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2585/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q04179"", ""source_assertion"": ""UniProtKB:Q04179 has the exact SGD cross-reference SGD:S000002808."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2585/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q04179"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q04179 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_location-072f393379b1_30e4c8b42406	SGD:S000005295	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P27515	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P27515"", ""source_assertion"": ""UniProtKB:P27515 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/761/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P27515"", ""source_assertion"": ""UniProtKB:P27515 has the exact SGD cross-reference SGD:S000005295."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/761/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P27515"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P27515 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_location-e14f680b5618_8c804947f034	SGD:S000005295	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P27515	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P27515"", ""source_assertion"": ""UniProtKB:P27515 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/761/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P27515"", ""source_assertion"": ""UniProtKB:P27515 has the exact SGD cross-reference SGD:S000005295."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/761/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P27515"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P27515 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_location-77bf27fc8523_10758fe45d16	SGD:S000001550	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36010	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12472466) Source qualification: Localizes predominantly to the cytoplasm. A small fraction is present in the mitochondrial intermembrane space	"[{""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 has the exact SGD cross-reference SGD:S000001550."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P36010"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36010 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_location-551208086c3a_cc02e9dc1284	SGD:S000001550	RO:0001025	GO:0005758	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36010	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12472466); ECO:0000269 (PubMed:16823961); ECO:0000269 (PubMed:22984289) Source qualification: Localizes predominantly to the cytoplasm. A small fraction is present in the mitochondrial intermembrane space	"[{""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 annotates location Mitochondrion intermembrane space (SL-0169)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 has the exact SGD cross-reference SGD:S000001550."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P36010"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36010 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_location-a2a6f57b59f0_88a11faf3628	SGD:S000001507	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15700	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03172); ECO:0000269 (PubMed:1333436); ECO:0000269 (PubMed:8391780) Source qualification: Predominantly cytoplasmic	"[{""reference_id"": ""UniProtKB:P15700"", ""source_assertion"": ""UniProtKB:P15700 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/422/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P15700"", ""source_assertion"": ""UniProtKB:P15700 has the exact SGD cross-reference SGD:S000001507."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/422/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P15700"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P15700 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_location-1b5902281c56_a63270666cc2	SGD:S000001507	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15700	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03172); ECO:0000269 (PubMed:1333436); ECO:0000269 (PubMed:8391780) Source qualification: Predominantly cytoplasmic	"[{""reference_id"": ""UniProtKB:P15700"", ""source_assertion"": ""UniProtKB:P15700 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/422/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P15700"", ""source_assertion"": ""UniProtKB:P15700 has the exact SGD cross-reference SGD:S000001507."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/422/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P15700"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P15700 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_location-d06e8b4886f2_47c1c20dd013	SGD:S000006266	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12178	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q12178"", ""source_assertion"": ""UniProtKB:Q12178 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3006/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q12178"", ""source_assertion"": ""UniProtKB:Q12178 has the exact SGD cross-reference SGD:S000006266."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3006/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q12178"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12178 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_location-4ecef5e53f37_e4282d5a825b	SGD:S000006266	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12178	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q12178"", ""source_assertion"": ""UniProtKB:Q12178 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3006/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q12178"", ""source_assertion"": ""UniProtKB:Q12178 has the exact SGD cross-reference SGD:S000006266."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3006/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q12178"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12178 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_cofactor-857dafe2b77d_172042146ef9	SGD:S000001550	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36010	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:5793714)	"[{""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1183/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 has the exact SGD cross-reference SGD:S000001550."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1183/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P36010"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36010 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_cofactor-4142683ba983_9f5cf3e55b83	SGD:S000001507	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15700	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The dispute concerns nucleoside substrate specificity, not magnesium dependence; keep the metal assertion without expanding substrate scope. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03172); ECO:0000269 (PubMed:16240436); ECO:0000269 (PubMed:8391780) Binds 1 Mg(2+) ion per monomer. UniProt note evidence: ECO:0000255 (HAMAP-Rule:MF_03172); ECO:0000269 (PubMed:16240436); ECO:0000269 (PubMed:8391780)	"[{""reference_id"": ""UniProtKB:P15700"", ""source_assertion"": ""UniProtKB:P15700 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/422/comments/0/cofactors/0; /results/422/comments/0/note""}, {""reference_id"": ""UniProtKB:P15700"", ""source_assertion"": ""UniProtKB:P15700 has the exact SGD cross-reference SGD:S000001507."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/422/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P15700"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P15700 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_cofactor-7e9d218662f5_bd2dad79f643	SGD:S000006266	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12178	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:12637534); ECO:0000269 (PubMed:12906827); ECO:0000269 (PubMed:15879217)	"[{""reference_id"": ""UniProtKB:Q12178"", ""source_assertion"": ""UniProtKB:Q12178 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3006/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:Q12178"", ""source_assertion"": ""UniProtKB:Q12178 has the exact SGD cross-reference SGD:S000006266."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3006/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q12178"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12178 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_cofactor-99b40c427dff_99a14a3588a0	SGD:S000004235	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06549	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:Q06549"", ""source_assertion"": ""UniProtKB:Q06549 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2769/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:Q06549"", ""source_assertion"": ""UniProtKB:Q06549 has the exact SGD cross-reference SGD:S000004235."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2769/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q06549"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB Q06549 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_YEAST-RNT-SALV_cofactor-f7a4694fc802_48f64603c19f	SGD:S000001170	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P18562	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P18562"", ""source_assertion"": ""UniProtKB:P18562 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3318/comments/0/cofactors/0; /results/3318/comments/0/note""}, {""reference_id"": ""UniProtKB:P18562"", ""source_assertion"": ""UniProtKB:P18562 has the exact SGD cross-reference SGD:S000001170."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3318/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P18562"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P18562 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-001_a6d9d337202e	gomodel:RXN-13403	RO:0002413	gomodel:DIMETHUROPORDEHYDROG-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:RXN-13403 RO:0002413 gomodel:DIMETHUROPORDEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/0; endpoint types: /individuals/16/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-002_6c5323d67c28	gomodel:SIROHEME-FERROCHELAT-RXN	RO:0002233	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:SIROHEME-FERROCHELAT-RXN RO:0002233 gomodel:CHEBI_29033_SIROHEME-FERROCHELAT-RXN."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/1; endpoint types: /individuals/17/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-003_a304b1f6e4f0	gomodel:DIMETHUROPORDEHYDROG-RXN	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:DIMETHUROPORDEHYDROG-RXN RO:0002234 gomodel:CHEBI_57945_DIMETHUROPORDEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/2; endpoint types: /individuals/12/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-004_7ad9bb91e088	gomodel:RXN-13403	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:RXN-13403 RO:0002234 gomodel:CHEBI_15378_RXN-13403."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/3; endpoint types: /individuals/16/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-005_12ee1126f1b4	gomodel:DIMETHUROPORDEHYDROG-RXN	RO:0002234	CHEBI:58351	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:DIMETHUROPORDEHYDROG-RXN RO:0002234 gomodel:CHEBI_58351_DIMETHUROPORDEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/4; endpoint types: /individuals/12/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-006_b39be4dac3bd	gomodel:RXN-13403	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:RXN-13403 BFO:0000066 gomodel:reaction_RXN-13403_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/5; endpoint types: /individuals/16/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-007_525b1aa0b1b1	gomodel:DIMETHUROPORDEHYDROG-RXN	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:DIMETHUROPORDEHYDROG-RXN RO:0002233 gomodel:CHEBI_57540_DIMETHUROPORDEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/6; endpoint types: /individuals/12/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-008_e3384cadbb36	gomodel:SIROHEME-FERROCHELAT-RXN	RO:0002233	CHEBI:58351	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:SIROHEME-FERROCHELAT-RXN RO:0002233 gomodel:CHEBI_58351_DIMETHUROPORDEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/7; endpoint types: /individuals/17/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-009_5d30f9fb0172	gomodel:RXN-13403	RO:0002234	CHEBI:57856	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:RXN-13403 RO:0002234 gomodel:CHEBI_57856_RXN-13403."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/8; endpoint types: /individuals/16/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-010_0684ebf78a9f	gomodel:DIMETHUROPORDEHYDROG-RXN	BFO:0000050	GO:0019354	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:DIMETHUROPORDEHYDROG-RXN BFO:0000050 gomodel:YeastPathways_PWY-5194-1/YeastPathways_PWY-5194-1."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/9; endpoint types: /individuals/12/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-011_13d028e16cd8	gomodel:SIROHEME-FERROCHELAT-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:SIROHEME-FERROCHELAT-RXN RO:0002234 gomodel:CHEBI_15378_SIROHEME-FERROCHELAT-RXN."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/10; endpoint types: /individuals/17/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-012_a87feaa8247a	gomodel:DIMETHUROPORDEHYDROG-RXN	RO:0002233	CHEBI:58827	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:DIMETHUROPORDEHYDROG-RXN RO:0002233 gomodel:CHEBI_58827_RXN-13403."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/11; endpoint types: /individuals/12/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-013_86a0b40979e3	gomodel:RXN-13403	RO:0002233	CHEBI:57308	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:RXN-13403 RO:0002233 gomodel:CHEBI_57308_RXN-13403."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/12; endpoint types: /individuals/16/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-014_584154573387	gomodel:SIROHEME-FERROCHELAT-RXN	RO:0002234	CHEBI:60052	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:SIROHEME-FERROCHELAT-RXN RO:0002234 gomodel:CHEBI_60052_SIROHEME-FERROCHELAT-RXN."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/13; endpoint types: /individuals/17/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-015_da70c6d6c029	gomodel:DIMETHUROPORDEHYDROG-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:DIMETHUROPORDEHYDROG-RXN RO:0002234 gomodel:CHEBI_15378_DIMETHUROPORDEHYDROG-RXN."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/14; endpoint types: /individuals/12/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-016_71c726b54744	gomodel:RXN-13403	RO:0002233	CHEBI:59789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:RXN-13403 RO:0002233 gomodel:CHEBI_59789_RXN-13403."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/15; endpoint types: /individuals/16/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-017_f5d702f46274	gomodel:DIMETHUROPORDEHYDROG-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:DIMETHUROPORDEHYDROG-RXN BFO:0000066 gomodel:reaction_DIMETHUROPORDEHYDROG-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/16; endpoint types: /individuals/12/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-018_ec0b93152e58	SGD:S000001777	pathwaymech:enables	gomodel:RXN-13403	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:RXN-13403 RO:0002333 gomodel:MONOMER3O-47_RXN-13403_controller."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/17; endpoint types: /individuals/16/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-019_af5ff99cbba9	gomodel:RXN-13403	BFO:0000050	GO:0019354	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:RXN-13403 BFO:0000050 gomodel:YeastPathways_PWY-5194-1/YeastPathways_PWY-5194-1."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/18; endpoint types: /individuals/16/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-020_420276a772f5	gomodel:SIROHEME-FERROCHELAT-RXN	BFO:0000050	GO:0019354	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:SIROHEME-FERROCHELAT-RXN BFO:0000050 gomodel:YeastPathways_PWY-5194-1/YeastPathways_PWY-5194-1."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/19; endpoint types: /individuals/17/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-021_51fcb2667adc	SGD:S000000417	pathwaymech:enables	gomodel:DIMETHUROPORDEHYDROG-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:DIMETHUROPORDEHYDROG-RXN RO:0002333 gomodel:MONOMER3O-106_DIMETHUROPORDEHYDROG-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/20; endpoint types: /individuals/12/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-022_551092c7b296	gomodel:SIROHEME-FERROCHELAT-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:SIROHEME-FERROCHELAT-RXN BFO:0000066 gomodel:reaction_SIROHEME-FERROCHELAT-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/21; endpoint types: /individuals/17/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-023_62092bd7ca2a	SGD:S000000417	pathwaymech:enables	gomodel:SIROHEME-FERROCHELAT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:SIROHEME-FERROCHELAT-RXN RO:0002333 gomodel:MONOMER3O-106_SIROHEME-FERROCHELAT-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/22; endpoint types: /individuals/17/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-024_6a6e4ad74640	gomodel:DIMETHUROPORDEHYDROG-RXN	RO:0002413	gomodel:SIROHEME-FERROCHELAT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:DIMETHUROPORDEHYDROG-RXN RO:0002413 gomodel:SIROHEME-FERROCHELAT-RXN."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/23; endpoint types: /individuals/12/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5194-1_edge-025_a94a437ddf94	gomodel:RXN-13403	RO:0002234	CHEBI:58827	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5194-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_assertion"": ""The model asserts gomodel:RXN-13403 RO:0002234 gomodel:CHEBI_58827_RXN-13403."", ""source_locator"": ""./YeastPathways_PWY-5194-1.json#/facts/24; endpoint types: /individuals/16/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5194-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5194-1.json"", ""title"": ""GO-CAM siroheme biosynthesis model YeastPathways_PWY-5194-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_BSUBPOLYAMSYN-PWY_edge-001_a511c1053d52	gomodel:SPERMIDINESYN-RXN	RO:0002233	CHEBI:57443	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_BSUBPOLYAMSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:SPERMIDINESYN-RXN RO:0002233 gomodel:CHEBI_57443_SAMDECARB-RXN."", ""source_locator"": ""./YeastPathways_BSUBPOLYAMSYN-PWY.json#/facts/0; endpoint types: /individuals/9/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_BSUBPOLYAMSYN-PWY.json"", ""title"": ""GO-CAM spermidine biosynthesis I model YeastPathways_BSUBPOLYAMSYN-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_BSUBPOLYAMSYN-PWY_edge-002_06c4edb5129e	gomodel:SAMDECARB-RXN	BFO:0000050	GO:0008295	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_BSUBPOLYAMSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:SAMDECARB-RXN BFO:0000050 gomodel:YeastPathways_BSUBPOLYAMSYN-PWY/YeastPathways_BSUBPOLYAMSYN-PWY."", ""source_locator"": ""./YeastPathways_BSUBPOLYAMSYN-PWY.json#/facts/1; endpoint types: /individuals/8/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_BSUBPOLYAMSYN-PWY.json"", ""title"": ""GO-CAM spermidine biosynthesis I model YeastPathways_BSUBPOLYAMSYN-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_BSUBPOLYAMSYN-PWY_edge-003_5d48c15cb348	gomodel:SAMDECARB-RXN	RO:0002234	CHEBI:57443	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_BSUBPOLYAMSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:SAMDECARB-RXN RO:0002234 gomodel:CHEBI_57443_SAMDECARB-RXN."", ""source_locator"": ""./YeastPathways_BSUBPOLYAMSYN-PWY.json#/facts/2; endpoint types: /individuals/8/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_BSUBPOLYAMSYN-PWY.json"", ""title"": ""GO-CAM spermidine biosynthesis I model YeastPathways_BSUBPOLYAMSYN-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_BSUBPOLYAMSYN-PWY_edge-004_b92ad5d61406	gomodel:SPERMIDINESYN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_BSUBPOLYAMSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:SPERMIDINESYN-RXN BFO:0000066 gomodel:reaction_SPERMIDINESYN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_BSUBPOLYAMSYN-PWY.json#/facts/3; endpoint types: /individuals/9/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_BSUBPOLYAMSYN-PWY.json"", ""title"": ""GO-CAM spermidine biosynthesis I model YeastPathways_BSUBPOLYAMSYN-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_BSUBPOLYAMSYN-PWY_edge-005_dab3ce2f5d9e	gomodel:SAMDECARB-RXN	RO:0002233	CHEBI:59789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_BSUBPOLYAMSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:SAMDECARB-RXN RO:0002233 gomodel:CHEBI_59789_SAMDECARB-RXN."", ""source_locator"": ""./YeastPathways_BSUBPOLYAMSYN-PWY.json#/facts/4; endpoint types: /individuals/8/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_BSUBPOLYAMSYN-PWY.json"", ""title"": ""GO-CAM spermidine biosynthesis I model YeastPathways_BSUBPOLYAMSYN-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_BSUBPOLYAMSYN-PWY_edge-006_ff41386fc46c	gomodel:SAMDECARB-RXN	RO:0002413	gomodel:SPERMIDINESYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_BSUBPOLYAMSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:SAMDECARB-RXN RO:0002413 gomodel:SPERMIDINESYN-RXN."", ""source_locator"": ""./YeastPathways_BSUBPOLYAMSYN-PWY.json#/facts/5; endpoint types: /individuals/8/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_BSUBPOLYAMSYN-PWY.json"", ""title"": ""GO-CAM spermidine biosynthesis I model YeastPathways_BSUBPOLYAMSYN-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_BSUBPOLYAMSYN-PWY_edge-007_2d7b769820a8	gomodel:SAMDECARB-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_BSUBPOLYAMSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:SAMDECARB-RXN RO:0002234 gomodel:CHEBI_16526_SAMDECARB-RXN."", ""source_locator"": ""./YeastPathways_BSUBPOLYAMSYN-PWY.json#/facts/6; endpoint types: /individuals/8/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_BSUBPOLYAMSYN-PWY.json"", ""title"": ""GO-CAM spermidine biosynthesis I model YeastPathways_BSUBPOLYAMSYN-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_BSUBPOLYAMSYN-PWY_edge-008_080005bd94d1	gomodel:SPERMIDINESYN-RXN	RO:0002234	CHEBI:17509	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_BSUBPOLYAMSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:SPERMIDINESYN-RXN RO:0002234 gomodel:CHEBI_17509_SPERMIDINESYN-RXN."", ""source_locator"": ""./YeastPathways_BSUBPOLYAMSYN-PWY.json#/facts/7; endpoint types: /individuals/9/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_BSUBPOLYAMSYN-PWY.json"", ""title"": ""GO-CAM spermidine biosynthesis I model YeastPathways_BSUBPOLYAMSYN-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_BSUBPOLYAMSYN-PWY_edge-009_05f6c7a7f515	gomodel:SPERMIDINESYN-RXN	RO:0002234	CHEBI:57834	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_BSUBPOLYAMSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:SPERMIDINESYN-RXN RO:0002234 gomodel:CHEBI_57834_SPERMIDINESYN-RXN."", ""source_locator"": ""./YeastPathways_BSUBPOLYAMSYN-PWY.json#/facts/8; endpoint types: /individuals/9/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_BSUBPOLYAMSYN-PWY.json"", ""title"": ""GO-CAM spermidine biosynthesis I model YeastPathways_BSUBPOLYAMSYN-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_BSUBPOLYAMSYN-PWY_edge-010_2603867e7ca0	gomodel:SAMDECARB-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_BSUBPOLYAMSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:SAMDECARB-RXN BFO:0000066 gomodel:reaction_SAMDECARB-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_BSUBPOLYAMSYN-PWY.json#/facts/9; endpoint types: /individuals/8/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_BSUBPOLYAMSYN-PWY.json"", ""title"": ""GO-CAM spermidine biosynthesis I model YeastPathways_BSUBPOLYAMSYN-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_BSUBPOLYAMSYN-PWY_edge-011_94245de8293f	gomodel:SAMDECARB-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_BSUBPOLYAMSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:SAMDECARB-RXN RO:0002233 gomodel:CHEBI_15378_SAMDECARB-RXN."", ""source_locator"": ""./YeastPathways_BSUBPOLYAMSYN-PWY.json#/facts/10; endpoint types: /individuals/8/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_BSUBPOLYAMSYN-PWY.json"", ""title"": ""GO-CAM spermidine biosynthesis I model YeastPathways_BSUBPOLYAMSYN-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_BSUBPOLYAMSYN-PWY_edge-012_e1d4314a6c8c	gomodel:SPERMIDINESYN-RXN	RO:0002233	CHEBI:326268	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_BSUBPOLYAMSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:SPERMIDINESYN-RXN RO:0002233 gomodel:CHEBI_326268_SPERMIDINESYN-RXN."", ""source_locator"": ""./YeastPathways_BSUBPOLYAMSYN-PWY.json#/facts/11; endpoint types: /individuals/9/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_BSUBPOLYAMSYN-PWY.json"", ""title"": ""GO-CAM spermidine biosynthesis I model YeastPathways_BSUBPOLYAMSYN-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_BSUBPOLYAMSYN-PWY_edge-013_a3f71dd751ca	SGD:S000006273	pathwaymech:enables	gomodel:SPERMIDINESYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_BSUBPOLYAMSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:SPERMIDINESYN-RXN RO:0002333 gomodel:YPR069C-MONOMER_SPERMIDINESYN-RXN_controller."", ""source_locator"": ""./YeastPathways_BSUBPOLYAMSYN-PWY.json#/facts/12; endpoint types: /individuals/9/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_BSUBPOLYAMSYN-PWY.json"", ""title"": ""GO-CAM spermidine biosynthesis I model YeastPathways_BSUBPOLYAMSYN-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_BSUBPOLYAMSYN-PWY_edge-014_b401426518ed	gomodel:SPERMIDINESYN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_BSUBPOLYAMSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:SPERMIDINESYN-RXN RO:0002234 gomodel:CHEBI_15378_SPERMIDINESYN-RXN."", ""source_locator"": ""./YeastPathways_BSUBPOLYAMSYN-PWY.json#/facts/13; endpoint types: /individuals/9/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_BSUBPOLYAMSYN-PWY.json"", ""title"": ""GO-CAM spermidine biosynthesis I model YeastPathways_BSUBPOLYAMSYN-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_BSUBPOLYAMSYN-PWY_edge-015_39ba87b6247b	SGD:S000005412	pathwaymech:enables	gomodel:SAMDECARB-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_BSUBPOLYAMSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:SAMDECARB-RXN RO:0002333 gomodel:YOL052C-MONOMER_SAMDECARB-RXN_controller."", ""source_locator"": ""./YeastPathways_BSUBPOLYAMSYN-PWY.json#/facts/14; endpoint types: /individuals/8/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_BSUBPOLYAMSYN-PWY.json"", ""title"": ""GO-CAM spermidine biosynthesis I model YeastPathways_BSUBPOLYAMSYN-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_BSUBPOLYAMSYN-PWY_edge-016_a79ae5e219df	gomodel:SPERMIDINESYN-RXN	BFO:0000050	GO:0008295	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_BSUBPOLYAMSYN-PWY		"[{""reference_id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_assertion"": ""The model asserts gomodel:SPERMIDINESYN-RXN BFO:0000050 gomodel:YeastPathways_BSUBPOLYAMSYN-PWY/YeastPathways_BSUBPOLYAMSYN-PWY."", ""source_locator"": ""./YeastPathways_BSUBPOLYAMSYN-PWY.json#/facts/15; endpoint types: /individuals/9/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_BSUBPOLYAMSYN-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_BSUBPOLYAMSYN-PWY.json"", ""title"": ""GO-CAM spermidine biosynthesis I model YeastPathways_BSUBPOLYAMSYN-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_BSUBPOLYAMSYN-PWY_cofactor-4d6566054937_0c9ddaf697bc	SGD:S000005412	pathwaymech:has_cofactor	CHEBI:45360	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:45360|UniProtKB:P21182	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The cofactor note explicitly describes a covalently bound pyruvoyl group; use the exact group class rather than free pyruvate. UniProt evidence: not specified Binds 1 pyruvoyl group covalently per subunit. UniProt note evidence: ECO:0000269 (PubMed:2266128)	"[{""reference_id"": ""CHEBI:45360"", ""source_assertion"": ""ChEBI labels CHEBI:45360 as pyruvoyl group."", ""source_locator"": ""chebi.obo [Term] id: CHEBI:45360; name: pyruvoyl group""}, {""reference_id"": ""UniProtKB:P21182"", ""source_assertion"": ""UniProtKB:P21182 cross-references CHEBI:15361, but its note specifies a covalently bound pyruvoyl group; that group is projected to CHEBI:45360."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/540/comments/0/cofactors/0; /results/540/comments/0/note""}, {""reference_id"": ""UniProtKB:P21182"", ""source_assertion"": ""UniProtKB:P21182 has the exact SGD cross-reference SGD:S000005412."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/540/uniProtKBCrossReferences/0""}]"	"[{""id"": ""CHEBI:45360"", ""source_sha256"": ""6cd3c7f18d8b22c577e110e00008fb288d8f5b34424bbe5011858747062f9dd9"", ""source_version"": ""ChEBI release 255"", ""title"": ""ChEBI CHEBI:45360: pyruvoyl group"", ""url"": ""https://ftp.ebi.ac.uk/pub/databases/chebi/ontology/chebi.obo""}, {""id"": ""UniProtKB:P21182"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P21182 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSPECAT-PWY_edge-001_9d601e2e19fa	gomodel:SPERMINE-SYNTHASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSPECAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_assertion"": ""The model asserts gomodel:SPERMINE-SYNTHASE-RXN BFO:0000066 gomodel:reaction_SPERMINE-SYNTHASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_ARGSPECAT-PWY.json#/facts/0; endpoint types: /individuals/9/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-12-11; member ./YeastPathways_ARGSPECAT-PWY.json"", ""title"": ""GO-CAM spermine biosynthesis model YeastPathways_ARGSPECAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSPECAT-PWY_edge-002_95457b548e39	gomodel:SPERMINE-SYNTHASE-RXN	RO:0002234	CHEBI:17509	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSPECAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_assertion"": ""The model asserts gomodel:SPERMINE-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_17509_SPERMINE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_ARGSPECAT-PWY.json#/facts/1; endpoint types: /individuals/9/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-12-11; member ./YeastPathways_ARGSPECAT-PWY.json"", ""title"": ""GO-CAM spermine biosynthesis model YeastPathways_ARGSPECAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSPECAT-PWY_edge-003_a5666d1abcce	gomodel:SPERMINE-SYNTHASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSPECAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_assertion"": ""The model asserts gomodel:SPERMINE-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_15378_SPERMINE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_ARGSPECAT-PWY.json#/facts/2; endpoint types: /individuals/9/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-12-11; member ./YeastPathways_ARGSPECAT-PWY.json"", ""title"": ""GO-CAM spermine biosynthesis model YeastPathways_ARGSPECAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSPECAT-PWY_edge-004_a73f5148e044	SGD:S000005412	pathwaymech:enables	gomodel:SAMDECARB-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSPECAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_assertion"": ""The model asserts gomodel:SAMDECARB-RXN RO:0002333 gomodel:YOL052C-MONOMER_SAMDECARB-RXN_controller."", ""source_locator"": ""./YeastPathways_ARGSPECAT-PWY.json#/facts/3; endpoint types: /individuals/8/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-12-11; member ./YeastPathways_ARGSPECAT-PWY.json"", ""title"": ""GO-CAM spermine biosynthesis model YeastPathways_ARGSPECAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSPECAT-PWY_edge-005_f582ea93218a	gomodel:SAMDECARB-RXN	BFO:0000050	GO:0006597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSPECAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_assertion"": ""The model asserts gomodel:SAMDECARB-RXN BFO:0000050 gomodel:YeastPathways_ARGSPECAT-PWY/YeastPathways_ARGSPECAT-PWY."", ""source_locator"": ""./YeastPathways_ARGSPECAT-PWY.json#/facts/4; endpoint types: /individuals/8/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-12-11; member ./YeastPathways_ARGSPECAT-PWY.json"", ""title"": ""GO-CAM spermine biosynthesis model YeastPathways_ARGSPECAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSPECAT-PWY_edge-006_769ede3de8d9	SGD:S000004136	pathwaymech:enables	gomodel:SPERMINE-SYNTHASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSPECAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_assertion"": ""The model asserts gomodel:SPERMINE-SYNTHASE-RXN RO:0002333 gomodel:YLR146C-MONOMER_SPERMINE-SYNTHASE-RXN_controller."", ""source_locator"": ""./YeastPathways_ARGSPECAT-PWY.json#/facts/5; endpoint types: /individuals/9/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-12-11; member ./YeastPathways_ARGSPECAT-PWY.json"", ""title"": ""GO-CAM spermine biosynthesis model YeastPathways_ARGSPECAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSPECAT-PWY_edge-007_dafa9a7a07fd	gomodel:SAMDECARB-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSPECAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_assertion"": ""The model asserts gomodel:SAMDECARB-RXN RO:0002233 gomodel:CHEBI_15378_SAMDECARB-RXN."", ""source_locator"": ""./YeastPathways_ARGSPECAT-PWY.json#/facts/6; endpoint types: /individuals/8/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-12-11; member ./YeastPathways_ARGSPECAT-PWY.json"", ""title"": ""GO-CAM spermine biosynthesis model YeastPathways_ARGSPECAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSPECAT-PWY_edge-008_fb6f770149a3	gomodel:SPERMINE-SYNTHASE-RXN	BFO:0000050	GO:0006597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSPECAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_assertion"": ""The model asserts gomodel:SPERMINE-SYNTHASE-RXN BFO:0000050 gomodel:YeastPathways_ARGSPECAT-PWY/YeastPathways_ARGSPECAT-PWY."", ""source_locator"": ""./YeastPathways_ARGSPECAT-PWY.json#/facts/7; endpoint types: /individuals/9/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-12-11; member ./YeastPathways_ARGSPECAT-PWY.json"", ""title"": ""GO-CAM spermine biosynthesis model YeastPathways_ARGSPECAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSPECAT-PWY_edge-009_5ea19b40939d	gomodel:SPERMINE-SYNTHASE-RXN	RO:0002233	CHEBI:57834	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSPECAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_assertion"": ""The model asserts gomodel:SPERMINE-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_57834_SPERMINE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_ARGSPECAT-PWY.json#/facts/8; endpoint types: /individuals/9/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-12-11; member ./YeastPathways_ARGSPECAT-PWY.json"", ""title"": ""GO-CAM spermine biosynthesis model YeastPathways_ARGSPECAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSPECAT-PWY_edge-010_9a9cb4f2f570	gomodel:SAMDECARB-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSPECAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_assertion"": ""The model asserts gomodel:SAMDECARB-RXN RO:0002234 gomodel:CHEBI_16526_SAMDECARB-RXN."", ""source_locator"": ""./YeastPathways_ARGSPECAT-PWY.json#/facts/9; endpoint types: /individuals/8/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-12-11; member ./YeastPathways_ARGSPECAT-PWY.json"", ""title"": ""GO-CAM spermine biosynthesis model YeastPathways_ARGSPECAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSPECAT-PWY_edge-011_70eb90478fcc	gomodel:SAMDECARB-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSPECAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_assertion"": ""The model asserts gomodel:SAMDECARB-RXN BFO:0000066 gomodel:reaction_SAMDECARB-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_ARGSPECAT-PWY.json#/facts/10; endpoint types: /individuals/8/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-12-11; member ./YeastPathways_ARGSPECAT-PWY.json"", ""title"": ""GO-CAM spermine biosynthesis model YeastPathways_ARGSPECAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSPECAT-PWY_edge-012_648039deed8e	gomodel:SPERMINE-SYNTHASE-RXN	RO:0002233	CHEBI:57443	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSPECAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_assertion"": ""The model asserts gomodel:SPERMINE-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_57443_SAMDECARB-RXN."", ""source_locator"": ""./YeastPathways_ARGSPECAT-PWY.json#/facts/11; endpoint types: /individuals/9/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-12-11; member ./YeastPathways_ARGSPECAT-PWY.json"", ""title"": ""GO-CAM spermine biosynthesis model YeastPathways_ARGSPECAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSPECAT-PWY_edge-013_97390b348391	gomodel:SAMDECARB-RXN	RO:0002234	CHEBI:57443	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSPECAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_assertion"": ""The model asserts gomodel:SAMDECARB-RXN RO:0002234 gomodel:CHEBI_57443_SAMDECARB-RXN."", ""source_locator"": ""./YeastPathways_ARGSPECAT-PWY.json#/facts/12; endpoint types: /individuals/8/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-12-11; member ./YeastPathways_ARGSPECAT-PWY.json"", ""title"": ""GO-CAM spermine biosynthesis model YeastPathways_ARGSPECAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSPECAT-PWY_edge-014_a46b6e8c3cfa	gomodel:SPERMINE-SYNTHASE-RXN	RO:0002234	CHEBI:45725	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSPECAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_assertion"": ""The model asserts gomodel:SPERMINE-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_45725_SPERMINE-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_ARGSPECAT-PWY.json#/facts/13; endpoint types: /individuals/9/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-12-11; member ./YeastPathways_ARGSPECAT-PWY.json"", ""title"": ""GO-CAM spermine biosynthesis model YeastPathways_ARGSPECAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSPECAT-PWY_edge-015_6aca1474a8b4	gomodel:SAMDECARB-RXN	RO:0002233	CHEBI:59789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_ARGSPECAT-PWY		"[{""reference_id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_assertion"": ""The model asserts gomodel:SAMDECARB-RXN RO:0002233 gomodel:CHEBI_59789_SAMDECARB-RXN."", ""source_locator"": ""./YeastPathways_ARGSPECAT-PWY.json#/facts/14; endpoint types: /individuals/8/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_ARGSPECAT-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2025-12-11; member ./YeastPathways_ARGSPECAT-PWY.json"", ""title"": ""GO-CAM spermine biosynthesis model YeastPathways_ARGSPECAT-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_ARGSPECAT-PWY_cofactor-4d6566054937_5d42e54d5d84	SGD:S000005412	pathwaymech:has_cofactor	CHEBI:45360	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:45360|UniProtKB:P21182	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The cofactor note explicitly describes a covalently bound pyruvoyl group; use the exact group class rather than free pyruvate. UniProt evidence: not specified Binds 1 pyruvoyl group covalently per subunit. UniProt note evidence: ECO:0000269 (PubMed:2266128)	"[{""reference_id"": ""CHEBI:45360"", ""source_assertion"": ""ChEBI labels CHEBI:45360 as pyruvoyl group."", ""source_locator"": ""chebi.obo [Term] id: CHEBI:45360; name: pyruvoyl group""}, {""reference_id"": ""UniProtKB:P21182"", ""source_assertion"": ""UniProtKB:P21182 cross-references CHEBI:15361, but its note specifies a covalently bound pyruvoyl group; that group is projected to CHEBI:45360."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/540/comments/0/cofactors/0; /results/540/comments/0/note""}, {""reference_id"": ""UniProtKB:P21182"", ""source_assertion"": ""UniProtKB:P21182 has the exact SGD cross-reference SGD:S000005412."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/540/uniProtKBCrossReferences/0""}]"	"[{""id"": ""CHEBI:45360"", ""source_sha256"": ""6cd3c7f18d8b22c577e110e00008fb288d8f5b34424bbe5011858747062f9dd9"", ""source_version"": ""ChEBI release 255"", ""title"": ""ChEBI CHEBI:45360: pyruvoyl group"", ""url"": ""https://ftp.ebi.ac.uk/pub/databases/chebi/ontology/chebi.obo""}, {""id"": ""UniProtKB:P21182"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P21182 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-002_bac20afd34cc	gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_16526_SERINE-C-PALMITOYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/1; endpoint types: /individuals/62/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-003_c88f56d07a67	gomodel:DHS-PHOSPHATASE-RXN	RO:0002233	CHEBI:57939	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:DHS-PHOSPHATASE-RXN RO:0002233 gomodel:CHEBI_57939_SPHINGANINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/2; endpoint types: /individuals/50/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-004_a379282d063c	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 RO:0002233 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006277."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/3; endpoint types: /individuals/256/type; /individuals/258/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-005_29aeda5b874a	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260	RO:0002413	gomodel:RXN3O-328	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260 RO:0002413 gomodel:RXN3O-328."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/4; endpoint types: /individuals/242/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-006_22d18c11c879	gomodel:RXN3O-663	RO:0002233	CHEBI:57527	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-663 RO:0002233 gomodel:CHEBI_57527_RXN3O-663."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/5; endpoint types: /individuals/60/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-007_a8a8e7200616	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 BFO:0000066 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006216."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/6; endpoint types: /individuals/193/type; /individuals/200/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-008_93afae8a3019	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275	RO:0002413	gomodel:RXN3O-328	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 RO:0002413 gomodel:RXN3O-328."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/7; endpoint types: /individuals/256/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-009_9a10a107a231	gomodel:DHS-PHOSPHATASE-RXN	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:DHS-PHOSPHATASE-RXN BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/8; endpoint types: /individuals/50/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-010_e9859c341c87	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208	RO:0002413	gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 RO:0002413 gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/9; endpoint types: /individuals/193/type; /individuals/174/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-011_9c2312f1ea90	gomodel:RXN3O-4042	RO:0002234	CHEBI:31998	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4042 RO:0002234 gomodel:CHEBI_31998_RXN3O-4042."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/10; endpoint types: /individuals/56/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-012_eea130adac9e	gomodel:RXN3O-328	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-328 RO:0002234 gomodel:CHEBI_57287_RXN3O-328."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/11; endpoint types: /individuals/55/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-013_bf3023f8e316	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 RO:0002234 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006294."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/12; endpoint types: /individuals/272/type; /individuals/274/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-014_47ab910e0409	gomodel:RXN3O-680	RO:0002233	CHEBI:16749	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-680 RO:0002233 gomodel:CHEBI_16749_RXN3O-680."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/13; endpoint types: /individuals/61/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-015_4337278ee5db	SGD:S000002705	pathwaymech:enables	gomodel:RXN3O-1380	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-1380 RO:0002333 gomodel:YDR297W-MONOMER_RXN3O-1380_controller."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/14; endpoint types: /individuals/54/type; /individuals/68/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-016_d1c436457079	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/15; endpoint types: /individuals/272/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-017_f39883fa8b20	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241	RO:0002413	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 RO:0002413 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/16; endpoint types: /individuals/224/type; /individuals/211/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-018_cc3e35e93a2e	gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN	RO:0002413	gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN RO:0002413 gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/17; endpoint types: /individuals/62/type; /individuals/174/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-019_3cb760ea77a9	gomodel:RXN3O-328	RO:0002413	gomodel:RXN3O-4042	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-328 RO:0002413 gomodel:RXN3O-4042."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/18; endpoint types: /individuals/55/type; /individuals/56/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-020_c7d3354ba93a	gomodel:RXN3O-4042	RO:0002233	CHEBI:31998	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4042 RO:0002233 gomodel:CHEBI_31998_RXN3O-328."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/19; endpoint types: /individuals/56/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-021_c55a41e973d2	gomodel:RXN3O-1380	RO:0002413	gomodel:RXN3O-458	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-1380 RO:0002413 gomodel:RXN3O-458."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/20; endpoint types: /individuals/54/type; /individuals/57/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-022_da2fe838bf63	gomodel:RXN3O-581	RO:0002413	gomodel:RXN3O-663	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-581 RO:0002413 gomodel:RXN3O-663."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/21; endpoint types: /individuals/59/type; /individuals/60/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-023_26dce95c863d	SGD:S000001761	pathwaymech:enables	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227 RO:0002333 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006231."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/22; endpoint types: /individuals/211/type; /individuals/214/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-024_29849f57b373	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 RO:0002233 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006242."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/23; endpoint types: /individuals/224/type; /individuals/225/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-025_230f0b47798b	gomodel:RXN3O-581	RO:0002233	CHEBI:16749	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-581 RO:0002233 gomodel:CHEBI_16749_RXN3O-581."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/24; endpoint types: /individuals/59/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-026_a25baad3f5b0	gomodel:RXN3O-328	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-328 BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/25; endpoint types: /individuals/55/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-027_1bbbafd419d7	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 RO:0002234 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006212."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/26; endpoint types: /individuals/193/type; /individuals/197/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-028_5b2efa5f1c5e	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241	RO:0002413	gomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 RO:0002413 gomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/27; endpoint types: /individuals/224/type; /individuals/63/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-029_4775571fb684	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292	RO:0002413	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 RO:0002413 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/28; endpoint types: /individuals/272/type; /individuals/242/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-032_51953b5f1d78	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292	RO:0002413	gomodel:CERAMIDASE-YEAST-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 RO:0002413 gomodel:CERAMIDASE-YEAST-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/31; endpoint types: /individuals/272/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-033_bf354286bf57	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227	RO:0002234	CHEBI:57817	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227 RO:0002234 gomodel:CHEBI_57817_3-DEHYDROSPHINGANINE-REDUCTASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/32; endpoint types: /individuals/211/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-034_d70cdeb0589b	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208	RO:0002233	CHEBI:33384	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 RO:0002233 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006211."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/33; endpoint types: /individuals/193/type; /individuals/196/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-036_5daa2c88bba0	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241	RO:0002234	CHEBI:57939	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 RO:0002234 gomodel:CHEBI_57939_SPHINGANINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/35; endpoint types: /individuals/224/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-037_a164054cb085	gomodel:RXN3O-663	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-663 BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/36; endpoint types: /individuals/60/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-038_e39a83f1cfb4	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208	RO:0002234	CHEBI:58299	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 RO:0002234 gomodel:CHEBI_58299_SERINE-C-PALMITOYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/37; endpoint types: /individuals/193/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-039_9ce40f445a7d	gomodel:RXN3O-4042	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4042 RO:0002234 gomodel:CHEBI_15377_RXN3O-4042."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/38; endpoint types: /individuals/56/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-040_bd13061620b2	gomodel:RXN3O-458	RO:0002234	CHEBI:64795	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-458 RO:0002234 gomodel:CHEBI_64795_RXN3O-458."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/39; endpoint types: /individuals/57/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-042_7e8c8dc8da3b	gomodel:RXN3O-581	RO:0002234	CHEBI:17815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-581 RO:0002234 gomodel:CHEBI_17815_RXN3O-581."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/41; endpoint types: /individuals/59/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-044_94007c11ef85	gomodel:RXN3O-458	RO:0002413	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-458 RO:0002413 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/43; endpoint types: /individuals/57/type; /individuals/242/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-045_50ac2e9e0582	gomodel:RXN3O-663	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-663 RO:0002234 gomodel:CHEBI_15378_RXN3O-663."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/44; endpoint types: /individuals/60/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-046_615f2855142d	gomodel:RXN3O-680	RO:0002234	CHEBI:62682	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-680 RO:0002234 gomodel:CHEBI_62682_RXN3O-680."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/45; endpoint types: /individuals/61/type; /individuals/47/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-048_ceca95c9fae5	gomodel:RXN3O-1380	RO:0002234	CHEBI:64124	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-1380 RO:0002234 gomodel:CHEBI_64124_RXN3O-1380."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/47; endpoint types: /individuals/54/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-049_fa87d8f23578	gomodel:DHS-PHOSPHATASE-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:DHS-PHOSPHATASE-RXN RO:0002234 gomodel:CHEBI_43474_DHS-PHOSPHATASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/48; endpoint types: /individuals/50/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-050_f4d3b924b6f9	gomodel:RXN3O-328	RO:0002233	CHEBI:61910	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-328 RO:0002233 gomodel:CHEBI_61910_RXN3O-328."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/49; endpoint types: /individuals/55/type; /individuals/46/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-051_ed6eb3f3b7ec	gomodel:RXN3O-504	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-504 RO:0002234 gomodel:CHEBI_43474_RXN3O-504."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/50; endpoint types: /individuals/58/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-052_5e0877d93f8c	gomodel:CERAMIDASE-YEAST-RXN	RO:0002233	CHEBI:31998	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CERAMIDASE-YEAST-RXN RO:0002233 gomodel:CHEBI_31998_CERAMIDASE-YEAST-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/51; endpoint types: /individuals/0/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-053_5e72d13bbf4f	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 RO:0002233 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006293."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/52; endpoint types: /individuals/272/type; /individuals/273/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-054_d18e281ac99f	gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN RO:0002234 gomodel:CHEBI_58349_3-DEHYDROSPHINGANINE-REDUCTASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/53; endpoint types: /individuals/174/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-055_0c8d939cc4f1	SGD:S000001761	pathwaymech:enables	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260 RO:0002333 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006264."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/54; endpoint types: /individuals/242/type; /individuals/245/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-056_4d9277035339	gomodel:RXN3O-504	RO:0002413	gomodel:RXN3O-328	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-504 RO:0002413 gomodel:RXN3O-328."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/55; endpoint types: /individuals/58/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-057_90f905155990	gomodel:RXN3O-680	RO:0002233	CHEBI:25168	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-680 RO:0002233 gomodel:CHEBI_25168_RXN3O-663."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/56; endpoint types: /individuals/61/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-058_b6760066a9be	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 RO:0002234 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006295."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/57; endpoint types: /individuals/272/type; /individuals/275/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-059_4e5abc602656	gomodel:RXN3O-1380	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-1380 RO:0002233 gomodel:CHEBI_15378_RXN3O-1380."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/58; endpoint types: /individuals/54/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-060_cbe7d262873b	gomodel:RXN3O-663	RO:0002413	gomodel:RXN3O-680	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-663 RO:0002413 gomodel:RXN3O-680."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/59; endpoint types: /individuals/60/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-062_0b851c545dd4	gomodel:CERAMIDASE-YEAST-RXN	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CERAMIDASE-YEAST-RXN BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/61; endpoint types: /individuals/0/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-063_11de3c69b4d4	gomodel:RXN3O-1380	RO:0002413	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-1380 RO:0002413 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/62; endpoint types: /individuals/54/type; /individuals/272/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-065_98ca35104f66	gomodel:CERAMIDASE-YEAST-RXN	RO:0002413	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CERAMIDASE-YEAST-RXN RO:0002413 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/64; endpoint types: /individuals/0/type; /individuals/272/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-066_bac7982e4092	gomodel:CERAMIDASE-YEAST-RXN	RO:0002413	gomodel:RXN3O-328	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CERAMIDASE-YEAST-RXN RO:0002413 gomodel:RXN3O-328."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/65; endpoint types: /individuals/0/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-068_46fb2cc2f845	gomodel:RXN3O-458	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-458 BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/67; endpoint types: /individuals/57/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-069_0324fc343350	SGD:S000001487	pathwaymech:enables	gomodel:RXN3O-581	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-581 RO:0002333 gomodel:MONOMER3O-630_RXN3O-581_controller."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/68; endpoint types: /individuals/59/type; /individuals/53/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-070_0959c07719aa	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/69; endpoint types: /individuals/256/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-071_b6e586342538	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260	RO:0002233	CHEBI:64795	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260 RO:0002233 gomodel:CHEBI_64795_RXN3O-458."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/70; endpoint types: /individuals/242/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-072_887c4de128b6	gomodel:SPHINGANINE-KINASE-RXN	RO:0002413	gomodel:DHS-PHOSPHATASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SPHINGANINE-KINASE-RXN RO:0002413 gomodel:DHS-PHOSPHATASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/71; endpoint types: /individuals/64/type; /individuals/50/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-073_07b3fcb7bb3b	gomodel:RXN3O-1380	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-1380 RO:0002233 gomodel:CHEBI_15379_RXN3O-1380."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/72; endpoint types: /individuals/54/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-074_cc59c3f4a45a	gomodel:RXN3O-328	RO:0002234	CHEBI:31998	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-328 RO:0002234 gomodel:CHEBI_31998_RXN3O-328."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/73; endpoint types: /individuals/55/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-075_f741e790703c	gomodel:RXN3O-4042	RO:0002234	CHEBI:18097	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4042 RO:0002234 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/66b5638000000157."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/74; endpoint types: /individuals/56/type; /individuals/301/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-076_387bef94b2fa	gomodel:RXN3O-4042	RO:0002413	gomodel:RXN3O-581	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4042 RO:0002413 gomodel:RXN3O-581."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/75; endpoint types: /individuals/56/type; /individuals/59/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-077_2ff1aa494ee2	SGD:S000002702	pathwaymech:enables	gomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN RO:0002333 gomodel:YDR294C-MONOMER_SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN_controller."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/76; endpoint types: /individuals/63/type; /individuals/67/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-078_5149b543fc12	gomodel:RXN3O-1380	RO:0002233	CHEBI:57817	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-1380 RO:0002233 gomodel:CHEBI_57817_3-DEHYDROSPHINGANINE-REDUCTASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/77; endpoint types: /individuals/54/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-079_6bb9a12d04d1	gomodel:RXN3O-1380	RO:0002233	CHEBI:16518	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-1380 RO:0002233 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/66b5638000000142."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/78; endpoint types: /individuals/54/type; /individuals/294/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-080_87f2e02c7df4	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 RO:0002234 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006213."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/79; endpoint types: /individuals/193/type; /individuals/198/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-081_e5be92515f88	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292	RO:0002413	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 RO:0002413 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/80; endpoint types: /individuals/272/type; /individuals/256/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-082_b28ee72df01e	gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/81; endpoint types: /individuals/62/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-083_b972481559a2	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292	RO:0002234	CHEBI:64795	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 RO:0002234 gomodel:CHEBI_64795_RXN3O-458."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/82; endpoint types: /individuals/272/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-084_89fca13bbb8c	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/83; endpoint types: /individuals/224/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-086_2b3e28266ebc	gomodel:SPHINGANINE-KINASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SPHINGANINE-KINASE-RXN RO:0002234 gomodel:CHEBI_15378_SPHINGANINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/85; endpoint types: /individuals/64/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-087_70a9de58707a	gomodel:RXN3O-504	RO:0002233	CHEBI:64795	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-504 RO:0002233 gomodel:CHEBI_64795_RXN3O-458."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/86; endpoint types: /individuals/58/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-088_c738d8e25be0	gomodel:RXN3O-458	RO:0002233	CHEBI:64124	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-458 RO:0002233 gomodel:CHEBI_64124_RXN3O-1380."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/87; endpoint types: /individuals/57/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-089_ffbcdb08f7fb	gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_15378_SERINE-C-PALMITOYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/88; endpoint types: /individuals/62/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-090_bf05dad1e227	SGD:S000002479	pathwaymech:enables	gomodel:RXN3O-680	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-680 RO:0002333 gomodel:YDR072C-MONOMER_RXN3O-680_controller."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/89; endpoint types: /individuals/61/type; /individuals/66/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-091_569f5ba693e6	gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN RO:0002233 gomodel:CHEBI_15378_3-DEHYDROSPHINGANINE-REDUCTASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/90; endpoint types: /individuals/174/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-092_fc287d752e82	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275	RO:0002234	CHEBI:10283	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 RO:0002234 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006278."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/91; endpoint types: /individuals/256/type; /individuals/259/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-093_789917f02297	gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN	RO:0002234	CHEBI:57817	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN RO:0002234 gomodel:CHEBI_57817_3-DEHYDROSPHINGANINE-REDUCTASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/92; endpoint types: /individuals/174/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-094_0e1b82fe0bac	SGD:S000000469	pathwaymech:enables	gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN RO:0002333 gomodel:YBR265W-MONOMER_3-DEHYDROSPHINGANINE-REDUCTASE-RXN_controller."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/93; endpoint types: /individuals/174/type; /individuals/65/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-095_ca2c4b23df85	gomodel:RXN3O-458	RO:0002413	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-458 RO:0002413 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/94; endpoint types: /individuals/57/type; /individuals/256/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-096_52b4a92f1d27	gomodel:RXN3O-663	RO:0002234	CHEBI:58189	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-663 RO:0002234 gomodel:CHEBI_58189_RXN3O-663."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/95; endpoint types: /individuals/60/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-097_1431720f22e3	gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN	RO:0002233	CHEBI:57379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_57379_SERINE-C-PALMITOYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/96; endpoint types: /individuals/62/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-098_b872bceacb11	gomodel:SPHINGANINE-KINASE-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SPHINGANINE-KINASE-RXN RO:0002234 gomodel:CHEBI_456216_SPHINGANINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/97; endpoint types: /individuals/64/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-099_d44e913ed4b6	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 RO:0002234 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006244."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/98; endpoint types: /individuals/224/type; /individuals/227/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-100_1ae8b7b42f2b	gomodel:RXN3O-504	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-504 BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/99; endpoint types: /individuals/58/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-101_97de19547c98	gomodel:RXN3O-4042	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4042 BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/100; endpoint types: /individuals/56/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-102_6d69a4ec5410	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292	RO:0002413	gomodel:RXN3O-504	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 RO:0002413 gomodel:RXN3O-504."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/101; endpoint types: /individuals/272/type; /individuals/58/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-103_916c2c17affe	gomodel:RXN3O-1380	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-1380 RO:0002234 gomodel:CHEBI_15377_RXN3O-1380."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/102; endpoint types: /individuals/54/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-104_1d623cfa08f1	gomodel:RXN3O-458	RO:0002413	gomodel:RXN3O-504	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-458 RO:0002413 gomodel:RXN3O-504."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/103; endpoint types: /individuals/57/type; /individuals/58/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-105_aacdfb255226	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227 BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/104; endpoint types: /individuals/211/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-106_f7967bd9f15f	gomodel:RXN3O-4042	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4042 RO:0002233 gomodel:CHEBI_15378_RXN3O-4042."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/105; endpoint types: /individuals/56/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-107_a6053cfb7362	gomodel:DHS-PHOSPHATASE-RXN	RO:0002234	CHEBI:57817	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:DHS-PHOSPHATASE-RXN RO:0002234 gomodel:CHEBI_57817_3-DEHYDROSPHINGANINE-REDUCTASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/106; endpoint types: /individuals/50/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-108_bc0a9b6c1ed5	gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN	RO:0002233	CHEBI:58299	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN RO:0002233 gomodel:CHEBI_58299_SERINE-C-PALMITOYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/107; endpoint types: /individuals/174/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-109_9a227749d8a3	gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN BFO:0000066 gomodel:reaction_SERINE-C-PALMITOYLTRANSFERASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/108; endpoint types: /individuals/62/type; /individuals/171/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-110_a4e9f033e6cd	gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN	RO:0002233	CHEBI:33384	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_33384_SERINE-C-PALMITOYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/109; endpoint types: /individuals/62/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-111_64e5ed3149e7	gomodel:RXN3O-4042	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4042 RO:0002233 gomodel:CHEBI_15379_RXN3O-4042."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/110; endpoint types: /individuals/56/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-112_6b8180747b8e	gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN	RO:0002413	gomodel:SPHINGANINE-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN RO:0002413 gomodel:SPHINGANINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/111; endpoint types: /individuals/174/type; /individuals/64/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-113_e23fbc97c047	SGD:S000003670	pathwaymech:enables	gomodel:RXN3O-504	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-504 RO:0002333 gomodel:MONOMER3O-419_RXN3O-504_controller."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/112; endpoint types: /individuals/58/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-114_ab08799c1e5b	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292	RO:0002233	CHEBI:64124	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 RO:0002233 gomodel:CHEBI_64124_RXN3O-1380."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/113; endpoint types: /individuals/272/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-115_27fc7023ed61	gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/114; endpoint types: /individuals/174/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-117_be6fc2bbe20a	gomodel:SPHINGANINE-KINASE-RXN	RO:0002234	CHEBI:57939	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SPHINGANINE-KINASE-RXN RO:0002234 gomodel:CHEBI_57939_SPHINGANINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/116; endpoint types: /individuals/64/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-120_f1f52f24c337	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275	RO:0002413	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 RO:0002413 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/119; endpoint types: /individuals/256/type; /individuals/272/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-121_2e2a30ba83f5	gomodel:RXN3O-458	RO:0002413	gomodel:CERAMIDASE-YEAST-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-458 RO:0002413 gomodel:CERAMIDASE-YEAST-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/120; endpoint types: /individuals/57/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-122_ddb1ac9cbb21	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/121; endpoint types: /individuals/193/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-123_9abeecf299fd	gomodel:RXN3O-458	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-458 RO:0002234 gomodel:CHEBI_15378_RXN3O-458."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/122; endpoint types: /individuals/57/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-124_abb64e8e3bc4	SGD:S000003670	pathwaymech:enables	gomodel:DHS-PHOSPHATASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:DHS-PHOSPHATASE-RXN RO:0002333 gomodel:MONOMER3O-419_DHS-PHOSPHATASE-RXN_controller."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/123; endpoint types: /individuals/50/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-125_a1ca0df50a71	SGD:S000002469	pathwaymech:enables	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 RO:0002333 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006214."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/124; endpoint types: /individuals/193/type; /individuals/199/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-126_2cc31aa4f503	SGD:S000004911	pathwaymech:enables	gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN RO:0002333 gomodel:YMR296C-MONOMER_SERINE-C-PALMITOYLTRANSFERASE-RXN_controller."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/125; endpoint types: /individuals/62/type; /individuals/70/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-127_12e08ef74c66	gomodel:RXN3O-4042	RO:0002233	CHEBI:16518	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4042 RO:0002233 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/66b5638000000159."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/126; endpoint types: /individuals/56/type; /individuals/302/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-129_3776604be8f6	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260	RO:0002234	CHEBI:64124	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260 RO:0002234 gomodel:CHEBI_64124_RXN3O-1380."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/128; endpoint types: /individuals/242/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-130_57409de27043	gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN	RO:0002234	CHEBI:58299	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_58299_SERINE-C-PALMITOYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/129; endpoint types: /individuals/62/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-131_98b597407be9	gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN	RO:0002413	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN RO:0002413 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/130; endpoint types: /individuals/174/type; /individuals/224/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-132_60f9688d33a7	SGD:S000000387	pathwaymech:enables	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 RO:0002333 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006279."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/131; endpoint types: /individuals/256/type; /individuals/260/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-133_7976458554c2	SGD:S000218096	pathwaymech:enables	gomodel:RXN3O-328	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-328 RO:0002333 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006184."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/132; endpoint types: /individuals/55/type; /individuals/191/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-134_53923c64280d	gomodel:RXN3O-458	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-458 RO:0002233 gomodel:CHEBI_30616_RXN3O-458."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/133; endpoint types: /individuals/57/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-135_03e23c3f7f00	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260 RO:0002234 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006262."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/134; endpoint types: /individuals/242/type; /individuals/244/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-136_50358bc08f17	gomodel:RXN3O-581	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-581 BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/135; endpoint types: /individuals/59/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-137_9ddc748c2584	gomodel:CERAMIDASE-YEAST-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CERAMIDASE-YEAST-RXN RO:0002233 gomodel:CHEBI_15377_CERAMIDASE-YEAST-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/136; endpoint types: /individuals/0/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-138_cd9790d8f1bb	gomodel:RXN3O-663	RO:0002233	CHEBI:60245	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-663 RO:0002233 gomodel:CHEBI_60245_RXN3O-581."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/137; endpoint types: /individuals/60/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-139_f3e49a8c4433	gomodel:RXN3O-504	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-504 RO:0002233 gomodel:CHEBI_15377_RXN3O-504."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/138; endpoint types: /individuals/58/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-140_3c5195aa3848	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208	RO:0002233	CHEBI:57379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 RO:0002233 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006210."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/139; endpoint types: /individuals/193/type; /individuals/195/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-141_ed283b7b8873	gomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN	RO:0002234	CHEBI:17600	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN RO:0002234 gomodel:CHEBI_17600_SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/140; endpoint types: /individuals/63/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-142_3817b069bf98	SGD:S000004250	pathwaymech:enables	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 RO:0002333 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006245."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/141; endpoint types: /individuals/224/type; /individuals/228/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-144_ef19c6b1b475	gomodel:RXN3O-680	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-680 BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/143; endpoint types: /individuals/61/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-145_de7597bc1fc3	gomodel:RXN3O-328	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-328 BFO:0000066 gomodel:reaction_RXN3O-328_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/144; endpoint types: /individuals/55/type; /individuals/164/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-146_0b661fb20361	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 RO:0002233 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006209."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/145; endpoint types: /individuals/193/type; /individuals/194/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-147_8e0ff4704f43	gomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN	RO:0002234	CHEBI:58190	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN RO:0002234 gomodel:CHEBI_58190_SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/146; endpoint types: /individuals/63/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-148_37fd09a8fd13	gomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/147; endpoint types: /individuals/63/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-149_940a436e142d	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275	RO:0002234	CHEBI:64124	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 RO:0002234 gomodel:CHEBI_64124_RXN3O-1380."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/148; endpoint types: /individuals/256/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-150_34b06d626ff9	gomodel:RXN3O-1380	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-1380 BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/149; endpoint types: /individuals/54/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-151_a8a43583a1e2	gomodel:SPHINGANINE-KINASE-RXN	RO:0002413	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SPHINGANINE-KINASE-RXN RO:0002413 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/150; endpoint types: /individuals/64/type; /individuals/211/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-152_810443884fda	gomodel:RXN3O-663	RO:0002234	CHEBI:25168	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-663 RO:0002234 gomodel:CHEBI_25168_RXN3O-663."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/151; endpoint types: /individuals/60/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-153_86da186fed9a	SGD:S000004885	pathwaymech:enables	gomodel:RXN3O-4042	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4042 RO:0002333 gomodel:YMR272C-MONOMER_RXN3O-4042_controller."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/152; endpoint types: /individuals/56/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-154_5182e3fa5f50	SGD:S000005697	pathwaymech:enables	gomodel:RXN3O-458	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-458 RO:0002333 gomodel:YOR171C-MONOMER_RXN3O-458_controller."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/153; endpoint types: /individuals/57/type; /individuals/71/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-155_e6c3d8b82fdd	gomodel:CERAMIDASE-YEAST-RXN	RO:0002234	CHEBI:10283	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CERAMIDASE-YEAST-RXN RO:0002234 gomodel:CHEBI_10283_CERAMIDASE-YEAST-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/154; endpoint types: /individuals/0/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-156_a05371c213bc	SGD:S000005697	pathwaymech:enables	gomodel:SPHINGANINE-KINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SPHINGANINE-KINASE-RXN RO:0002333 gomodel:YOR171C-MONOMER_SPHINGANINE-KINASE-RXN_controller."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/155; endpoint types: /individuals/64/type; /individuals/72/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-157_18e1b888680b	SGD:S000004250	pathwaymech:enables	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 RO:0002333 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006296."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/156; endpoint types: /individuals/272/type; /individuals/276/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-158_d061b5a8b116	gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_57287_SERINE-C-PALMITOYLTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/157; endpoint types: /individuals/62/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-159_313daca54f03	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227	RO:0002233	CHEBI:57939	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227 RO:0002233 gomodel:CHEBI_57939_SPHINGANINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/158; endpoint types: /individuals/211/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-160_55bb227e7f25	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275	RO:0002233	CHEBI:31998	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 RO:0002233 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006276."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/159; endpoint types: /individuals/256/type; /individuals/257/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-161_589ff4b91bf8	gomodel:RXN3O-581	RO:0002233	CHEBI:31998	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-581 RO:0002233 gomodel:CHEBI_31998_RXN3O-4042."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/160; endpoint types: /individuals/59/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-162_1dda5a12934e	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241	RO:0002233	CHEBI:57817	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 RO:0002233 gomodel:CHEBI_57817_3-DEHYDROSPHINGANINE-REDUCTASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/161; endpoint types: /individuals/224/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-163_fdee413dfce3	gomodel:CERAMIDASE-YEAST-RXN	RO:0002413	gomodel:RXN3O-458	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CERAMIDASE-YEAST-RXN RO:0002413 gomodel:RXN3O-458."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/162; endpoint types: /individuals/0/type; /individuals/57/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-164_84ba90cdbc09	gomodel:SPHINGANINE-KINASE-RXN	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SPHINGANINE-KINASE-RXN BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/163; endpoint types: /individuals/64/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-165_b7996d09c9aa	SGD:S000006008	pathwaymech:enables	gomodel:CERAMIDASE-YEAST-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CERAMIDASE-YEAST-RXN RO:0002333 gomodel:YPL087W-MONOMER_CERAMIDASE-YEAST-RXN_controller."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/164; endpoint types: /individuals/0/type; /individuals/73/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-166_3389db4d8e4c	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275	RO:0002413	gomodel:RXN3O-458	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 RO:0002413 gomodel:RXN3O-458."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/165; endpoint types: /individuals/256/type; /individuals/57/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-167_c9dc8434a2ef	gomodel:SPHINGANINE-KINASE-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SPHINGANINE-KINASE-RXN RO:0002233 gomodel:CHEBI_30616_SPHINGANINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/166; endpoint types: /individuals/64/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-168_dc9fe0dd67bd	gomodel:DHS-PHOSPHATASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:DHS-PHOSPHATASE-RXN RO:0002233 gomodel:CHEBI_15377_DHS-PHOSPHATASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/167; endpoint types: /individuals/50/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-169_c95483df3e6d	gomodel:SPHINGANINE-KINASE-RXN	RO:0002233	CHEBI:57817	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SPHINGANINE-KINASE-RXN RO:0002233 gomodel:CHEBI_57817_3-DEHYDROSPHINGANINE-REDUCTASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/168; endpoint types: /individuals/64/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-171_20d116c2f7ad	gomodel:RXN3O-328	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-328 RO:0002234 gomodel:CHEBI_15378_RXN3O-328."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/170; endpoint types: /individuals/55/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-172_8975dd6b50f1	gomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN	RO:0002233	CHEBI:57939	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN RO:0002233 gomodel:CHEBI_57939_SPHINGANINE-KINASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/171; endpoint types: /individuals/63/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-173_116fd5a32903	gomodel:RXN3O-1380	RO:0002234	CHEBI:18097	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-1380 RO:0002234 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/66b5638000000143."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/172; endpoint types: /individuals/54/type; /individuals/295/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-174_0ea694addd26	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260	BFO:0000050	GO:0030148	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260 BFO:0000050 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/YeastPathways_SPHINGOLIPID-SYN-PWY-1."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/173; endpoint types: /individuals/242/type; /individuals/175/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-175_50610942bf65	gomodel:RXN3O-458	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-458 RO:0002234 gomodel:CHEBI_456216_RXN3O-458."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/174; endpoint types: /individuals/57/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-176_04a68524f4ee	gomodel:RXN3O-680	RO:0002234	CHEBI:17815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-680 RO:0002234 gomodel:CHEBI_17815_RXN3O-680."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/175; endpoint types: /individuals/61/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-177_a34cf7ec1bcb	gomodel:SPHINGANINE-KINASE-RXN	RO:0002413	gomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:SPHINGANINE-KINASE-RXN RO:0002413 gomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/176; endpoint types: /individuals/64/type; /individuals/63/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-178_211dd5d50580	SGD:S000218211	pathwaymech:enables	gomodel:RXN3O-663	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-663 RO:0002333 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006182."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/177; endpoint types: /individuals/60/type; /individuals/189/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-179_e0b2ff00f256	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227 RO:0002233 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006228."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/178; endpoint types: /individuals/211/type; /individuals/212/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-180_38972aa606ca	gomodel:RXN3O-328	RO:0002233	CHEBI:64124	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-328 RO:0002233 gomodel:CHEBI_64124_RXN3O-1380."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/179; endpoint types: /individuals/55/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-181_3f12bc266e02	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241	RO:0002413	gomodel:DHS-PHOSPHATASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 RO:0002413 gomodel:DHS-PHOSPHATASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/180; endpoint types: /individuals/224/type; /individuals/50/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-182_56883934b4f7	gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN RO:0002233 gomodel:CHEBI_57783_3-DEHYDROSPHINGANINE-REDUCTASE-RXN."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/181; endpoint types: /individuals/174/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-183_a73909d7e555	gomodel:CERAMIDASE-YEAST-RXN	RO:0002234	CHEBI:64124	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:CERAMIDASE-YEAST-RXN RO:0002234 gomodel:CHEBI_64124_RXN3O-1380."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/182; endpoint types: /individuals/0/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-184_e986d9fab26f	gomodel:RXN3O-504	RO:0002234	CHEBI:64124	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-504 RO:0002234 gomodel:CHEBI_64124_RXN3O-1380."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/183; endpoint types: /individuals/58/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-185_935604ca0237	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227 RO:0002234 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006229."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/184; endpoint types: /individuals/211/type; /individuals/213/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-186_394eb6e8ac04	gomodel:RXN3O-581	RO:0002234	CHEBI:60245	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-581 RO:0002234 gomodel:CHEBI_60245_RXN3O-581."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/185; endpoint types: /individuals/59/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-187_837d0b2c5950	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260 RO:0002233 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006261."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/186; endpoint types: /individuals/242/type; /individuals/243/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_edge-188_2e9601701023	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1		"[{""reference_id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 RO:0002234 gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006243."", ""source_locator"": ""./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json#/facts/187; endpoint types: /individuals/224/type; /individuals/226/type""}]"	"[{""id"": ""gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json"", ""title"": ""SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_complex-ccfebbe1c79b_c71c1f2dde2e	SGD:S000218096	BFO:0000051	UniProtKB:P38703	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000218096	ECO:0000353: physical interaction evidence; source stoichiometry minValue: 1, maxValue: 1	"[{""reference_id"": ""SGD:S000218096"", ""source_assertion"": ""Complex Portal CPX-1706 lists P38703 as a protein component; complex evidence is ECO:0000353: physical interaction evidence."", ""source_locator"": ""Complex Portal JSON #/participants/0; /evidenceType""}]"	"[{""id"": ""SGD:S000218096"", ""source_sha256"": ""ffd4950d106647c53033872f3b03bfa760a193a0d85f1573afb37d675d8652c3"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-1706: Acyl-CoA ceramide synthase complex"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1706""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_complex-4d8af72783b7_5d3e609a53c4	SGD:S000218096	BFO:0000051	UniProtKB:P28496	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000218096	ECO:0000353: physical interaction evidence; source stoichiometry minValue: 1, maxValue: 1	"[{""reference_id"": ""SGD:S000218096"", ""source_assertion"": ""Complex Portal CPX-1706 lists P28496 as a protein component; complex evidence is ECO:0000353: physical interaction evidence."", ""source_locator"": ""Complex Portal JSON #/participants/1; /evidenceType""}]"	"[{""id"": ""SGD:S000218096"", ""source_sha256"": ""ffd4950d106647c53033872f3b03bfa760a193a0d85f1573afb37d675d8652c3"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-1706: Acyl-CoA ceramide synthase complex"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1706""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_complex-7b62ac187e76_62bcdd00c609	SGD:S000218096	BFO:0000051	UniProtKB:Q03579	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000218096	ECO:0000353: physical interaction evidence; source stoichiometry minValue: 2, maxValue: 2	"[{""reference_id"": ""SGD:S000218096"", ""source_assertion"": ""Complex Portal CPX-1706 lists Q03579 as a protein component; complex evidence is ECO:0000353: physical interaction evidence."", ""source_locator"": ""Complex Portal JSON #/participants/2; /evidenceType""}]"	"[{""id"": ""SGD:S000218096"", ""source_sha256"": ""ffd4950d106647c53033872f3b03bfa760a193a0d85f1573afb37d675d8652c3"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-1706: Acyl-CoA ceramide synthase complex"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1706""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_complex-f96a0dffb400_ade82498bb8c	SGD:S000218211	BFO:0000051	UniProtKB:P33300	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000218211	ECO:0000353: physical interaction evidence; stoichiometry unspecified	"[{""reference_id"": ""SGD:S000218211"", ""source_assertion"": ""Complex Portal CPX-1739 lists P33300 as a protein component; complex evidence is ECO:0000353: physical interaction evidence."", ""source_locator"": ""Complex Portal JSON #/participants/0; /evidenceType""}]"	"[{""id"": ""SGD:S000218211"", ""source_sha256"": ""5d1054a984220288b54c85c6c3f690a2bd9bc675ebb80943208912e96a5e3794"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-1739: Mannosyl phosphorylinositol ceramide synthase SUR1-CSG2"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1739""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_complex-82c199a2d6e6_be5185b38fb9	SGD:S000218211	BFO:0000051	UniProtKB:P35206	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000218211	ECO:0000353: physical interaction evidence; stoichiometry unspecified	"[{""reference_id"": ""SGD:S000218211"", ""source_assertion"": ""Complex Portal CPX-1739 lists P35206 as a protein component; complex evidence is ECO:0000353: physical interaction evidence."", ""source_locator"": ""Complex Portal JSON #/participants/1; /evidenceType""}]"	"[{""id"": ""SGD:S000218211"", ""source_sha256"": ""5d1054a984220288b54c85c6c3f690a2bd9bc675ebb80943208912e96a5e3794"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-1739: Mannosyl phosphorylinositol ceramide synthase SUR1-CSG2"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1739""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_complex-981742557bf6_80a9c5a1c2ab	SGD:S000218211	RO:0001025	GO:0005794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000218211	Complex location from the independent composition source; original GO-CAM activity locations are retained with their own provenance.	"[{""reference_id"": ""SGD:S000218211"", ""source_assertion"": ""Complex Portal CPX-1739 records cellular location GO:0005794 (Golgi apparatus); its evidence classification is ECO:0000353: physical interaction evidence."", ""source_locator"": ""Complex Portal JSON #/crossReferences/5; /evidenceType""}]"	"[{""id"": ""SGD:S000218211"", ""source_sha256"": ""5d1054a984220288b54c85c6c3f690a2bd9bc675ebb80943208912e96a5e3794"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-1739: Mannosyl phosphorylinositol ceramide synthase SUR1-CSG2"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1739""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-f5ba429f8417_23ce978e5378	SGD:S000002705	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38992	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:8868422) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P38992"", ""source_assertion"": ""UniProtKB:P38992 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1529/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38992"", ""source_assertion"": ""UniProtKB:P38992 has the exact SGD cross-reference SGD:S000002705."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1529/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38992"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38992 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-a920b975016d_db0160f1eca5	SGD:S000001761	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P23501	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10477278); ECO:0000269 (PubMed:10563329); ECO:0000269 (PubMed:9353337) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P23501"", ""source_assertion"": ""UniProtKB:P23501 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/617/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P23501"", ""source_assertion"": ""UniProtKB:P23501 has the exact SGD cross-reference SGD:S000001761."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/617/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P23501"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P23501 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-f44db3b9e210_030577d8f690	SGD:S000001487	RO:0001025	GO:0032580	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36107	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10888667); ECO:0000269 (PubMed:19726565) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P36107"", ""source_assertion"": ""UniProtKB:P36107 annotates location Golgi apparatus, Golgi stack membrane (SL-0136)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1220/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P36107"", ""source_assertion"": ""UniProtKB:P36107 has the exact SGD cross-reference SGD:S000001487."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1220/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P36107"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36107 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-d2b4586fc01b_cd02c3692ebb	SGD:S000002702	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q05567	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:18487605) Topology: Single-pass type I membrane protein. Source qualification: Localizes to the cortical and the perinuclear ER	"[{""reference_id"": ""UniProtKB:Q05567"", ""source_assertion"": ""UniProtKB:Q05567 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2675/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q05567"", ""source_assertion"": ""UniProtKB:Q05567 has the exact SGD cross-reference SGD:S000002702."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2675/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q05567"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q05567 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-c41410091303_90cc1e91334b	SGD:S000002479	RO:0001025	GO:0000139	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38954	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14583628) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P38954"", ""source_assertion"": ""UniProtKB:P38954 annotates location Golgi apparatus membrane (SL-0134)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1517/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38954"", ""source_assertion"": ""UniProtKB:P38954 has the exact SGD cross-reference SGD:S000002479."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1517/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38954"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38954 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-9e477f17d380_ff8e9ea3ac7f	SGD:S000000469	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38342	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:19141869) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P38342"", ""source_assertion"": ""UniProtKB:P38342 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1373/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38342"", ""source_assertion"": ""UniProtKB:P38342 has the exact SGD cross-reference SGD:S000000469."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1373/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38342"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38342 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-a5e5ae63c54f_7c1e458a2345	SGD:S000003670	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47013	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10477278); ECO:0000269 (PubMed:10563329); ECO:0000269 (PubMed:9353337) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P47013"", ""source_assertion"": ""UniProtKB:P47013 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1928/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P47013"", ""source_assertion"": ""UniProtKB:P47013 has the exact SGD cross-reference SGD:S000003670."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1928/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P47013"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47013 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-013dea019621_10957534d5ec	SGD:S000002469	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40970	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P40970"", ""source_assertion"": ""UniProtKB:P40970 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1788/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P40970"", ""source_assertion"": ""UniProtKB:P40970 has the exact SGD cross-reference SGD:S000002469."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1788/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40970"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40970 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-275a2bd108b2_508de63d164d	SGD:S000002469	RO:0001025	GO:0005783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40970	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P40970"", ""source_assertion"": ""UniProtKB:P40970 annotates location Endoplasmic reticulum (SL-0095)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1788/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P40970"", ""source_assertion"": ""UniProtKB:P40970 has the exact SGD cross-reference SGD:S000002469."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1788/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40970"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40970 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-8e6ee4b973f6_ed9239f18d16	SGD:S000002469	RO:0001025	GO:0016020	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40970	Physical protein location from reviewed UniProt. ECO:0000305 Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P40970"", ""source_assertion"": ""UniProtKB:P40970 annotates location Membrane (SL-0162)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1788/comments/1/subcellularLocations/2; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P40970"", ""source_assertion"": ""UniProtKB:P40970 has the exact SGD cross-reference SGD:S000002469."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1788/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40970"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40970 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-3952c8904264_94c051c2ca55	SGD:S000004911	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P25045	Physical protein location from reviewed UniProt. evidence code not specified by source	"[{""reference_id"": ""UniProtKB:P25045"", ""source_assertion"": ""UniProtKB:P25045 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/656/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P25045"", ""source_assertion"": ""UniProtKB:P25045 has the exact SGD cross-reference SGD:S000004911."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/656/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P25045"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P25045 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-cbec5ca894e3_28162b6f289c	SGD:S000004911	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P25045	Physical protein location from reviewed UniProt. evidence code not specified by source Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P25045"", ""source_assertion"": ""UniProtKB:P25045 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/656/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P25045"", ""source_assertion"": ""UniProtKB:P25045 has the exact SGD cross-reference SGD:S000004911."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/656/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P25045"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P25045 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-7d277fddf7af_f4780e9e723e	SGD:S000000387	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38298	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10900202); ECO:0000269 (PubMed:24866405) Topology: Multi-pass membrane protein. Source qualification: Localizes to the cortical ER	"[{""reference_id"": ""UniProtKB:P38298"", ""source_assertion"": ""UniProtKB:P38298 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1356/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38298"", ""source_assertion"": ""UniProtKB:P38298 has the exact SGD cross-reference SGD:S000000387."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1356/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38298"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38298 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-513a1d085073_65205b4652d0	SGD:S000004250	RO:0001025	GO:0000139	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06147	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12493772) Topology: Peripheral membrane protein.	"[{""reference_id"": ""UniProtKB:Q06147"", ""source_assertion"": ""UniProtKB:Q06147 annotates location Golgi apparatus membrane (SL-0134)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2716/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q06147"", ""source_assertion"": ""UniProtKB:Q06147 has the exact SGD cross-reference SGD:S000004250."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2716/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q06147"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06147 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-82d584d1e8fd_5b0f0adfc10d	SGD:S000004885	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q03529	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:Q03529"", ""source_assertion"": ""UniProtKB:Q03529 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2509/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q03529"", ""source_assertion"": ""UniProtKB:Q03529 has the exact SGD cross-reference SGD:S000004885."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2509/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q03529"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q03529 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-780d78031875_97f693b186eb	SGD:S000005697	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12246	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12459470); ECO:0000269 (PubMed:16141212) Topology: Peripheral membrane protein. Source qualification: LCB4 is synthesized in the cytosol, palmitoylated at the Golgi apparatus by AKR1, and then transported to the plasma membrane (PM) via the late Sec pathway. Most of the LCB4 is delivered further to the cortical ER (cER), which is closely adjacent to the PM. In stationary phase, G1 cell cycle arrest causes ER-localized LCB4 to be transported to the Golgi apparatus via the early Sec pathway, and finally to the vacuole via the MVB pathway, where it is degraded	"[{""reference_id"": ""UniProtKB:Q12246"", ""source_assertion"": ""UniProtKB:Q12246 annotates location Cell membrane (SL-0039)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3030/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q12246"", ""source_assertion"": ""UniProtKB:Q12246 has the exact SGD cross-reference SGD:S000005697."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3030/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q12246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-436afbff24b4_e45f79bf502d	SGD:S000005697	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12246	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12493772) Topology: Peripheral membrane protein. Source qualification: LCB4 is synthesized in the cytosol, palmitoylated at the Golgi apparatus by AKR1, and then transported to the plasma membrane (PM) via the late Sec pathway. Most of the LCB4 is delivered further to the cortical ER (cER), which is closely adjacent to the PM. In stationary phase, G1 cell cycle arrest causes ER-localized LCB4 to be transported to the Golgi apparatus via the early Sec pathway, and finally to the vacuole via the MVB pathway, where it is degraded	"[{""reference_id"": ""UniProtKB:Q12246"", ""source_assertion"": ""UniProtKB:Q12246 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3030/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q12246"", ""source_assertion"": ""UniProtKB:Q12246 has the exact SGD cross-reference SGD:S000005697."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3030/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q12246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-a990940e5bff_6a0aa8ff6656	SGD:S000005697	RO:0001025	GO:0031902	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12246	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12459470) Topology: Peripheral membrane protein. Source qualification: LCB4 is synthesized in the cytosol, palmitoylated at the Golgi apparatus by AKR1, and then transported to the plasma membrane (PM) via the late Sec pathway. Most of the LCB4 is delivered further to the cortical ER (cER), which is closely adjacent to the PM. In stationary phase, G1 cell cycle arrest causes ER-localized LCB4 to be transported to the Golgi apparatus via the early Sec pathway, and finally to the vacuole via the MVB pathway, where it is degraded	"[{""reference_id"": ""UniProtKB:Q12246"", ""source_assertion"": ""UniProtKB:Q12246 annotates location Late endosome membrane (SL-0151)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3030/comments/1/subcellularLocations/2; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q12246"", ""source_assertion"": ""UniProtKB:Q12246 has the exact SGD cross-reference SGD:S000005697."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3030/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q12246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-a05e9067b743_f8d4277689e1	SGD:S000005697	RO:0001025	GO:0000139	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12246	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12459470) Topology: Peripheral membrane protein. Source qualification: LCB4 is synthesized in the cytosol, palmitoylated at the Golgi apparatus by AKR1, and then transported to the plasma membrane (PM) via the late Sec pathway. Most of the LCB4 is delivered further to the cortical ER (cER), which is closely adjacent to the PM. In stationary phase, G1 cell cycle arrest causes ER-localized LCB4 to be transported to the Golgi apparatus via the early Sec pathway, and finally to the vacuole via the MVB pathway, where it is degraded	"[{""reference_id"": ""UniProtKB:Q12246"", ""source_assertion"": ""UniProtKB:Q12246 annotates location Golgi apparatus membrane (SL-0134)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3030/comments/1/subcellularLocations/3; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q12246"", ""source_assertion"": ""UniProtKB:Q12246 has the exact SGD cross-reference SGD:S000005697."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3030/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q12246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-ef34a7a9646d_6bf499828184	SGD:S000006008	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q02896	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10900202) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:Q02896"", ""source_assertion"": ""UniProtKB:Q02896 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2455/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q02896"", ""source_assertion"": ""UniProtKB:Q02896 has the exact SGD cross-reference SGD:S000006008."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2455/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q02896"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q02896 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-5815954932ad_e061862d852e	UniProtKB:P38703	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38703	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:34492164) Topology: Multi-pass membrane protein. Source qualification: Localized to both cortical and nuclear endoplasmic reticulum	"[{""reference_id"": ""UniProtKB:P38703"", ""source_assertion"": ""UniProtKB:P38703 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1415/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38703"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38703 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-2225cb979e9c_941ca0e99fc8	UniProtKB:P28496	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P28496	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10198056); ECO:0000269 (PubMed:14562095) Topology: Multi-pass membrane protein. Source qualification: The specific interaction of LAC1 and LIP1 at the lumen of the ER may be important for the enzymatic activity of the complex	"[{""reference_id"": ""UniProtKB:P28496"", ""source_assertion"": ""UniProtKB:P28496 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/792/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P28496"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P28496 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-5ad73165d223_367580fa0c72	UniProtKB:Q03579	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q03579	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:15692566) Topology: Single-pass type II membrane protein. Source qualification: The specific interaction of LAC1 and LIP1 at the lumen of the ER may be important for the enzymatic activity of the complex	"[{""reference_id"": ""UniProtKB:Q03579"", ""source_assertion"": ""UniProtKB:Q03579 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2516/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q03579"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q03579 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-945fd34b0c44_7b8fc7153d6c	UniProtKB:P33300	RO:0001025	GO:0016020	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33300	Physical protein location from reviewed UniProt. ECO:0000305 Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P33300"", ""source_assertion"": ""UniProtKB:P33300 annotates location Membrane (SL-0162)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1063/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P33300"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P33300 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-cc8ac224f835_e8499315e298	UniProtKB:P35206	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P35206	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:7854312) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P35206"", ""source_assertion"": ""UniProtKB:P35206 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1162/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P35206"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P35206 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_location-f1f67fe5b506_f8ec5a131c05	gomodel:RXN3O-663	BFO:0000066	GO:0005794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	SGD:S000218211	Functional compartment explicitly described by Complex Portal. ECO:0000353: physical interaction evidence.	"[{""reference_id"": ""SGD:S000218211"", ""source_assertion"": ""Complex Portal CPX-1739 places this complex's catalytic function in the Golgi apparatus."", ""source_locator"": ""CPX-1739.json#/functions/0""}]"	"[{""id"": ""SGD:S000218211"", ""source_sha256"": ""5d1054a984220288b54c85c6c3f690a2bd9bc675ebb80943208912e96a5e3794"", ""source_version"": ""Inspected API snapshot 2026-10-05; release dates 2014-10-16"", ""title"": ""Complex Portal CPX-1739: Mannosyl phosphorylinositol ceramide synthase SUR1-CSG2"", ""url"": ""https://www.ebi.ac.uk/intact/complex-ws/complex/CPX-1739""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_cofactor-834ffa25d08a_e68b177f2595	SGD:S000002702	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q05567	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:20696404)	"[{""reference_id"": ""UniProtKB:Q05567"", ""source_assertion"": ""UniProtKB:Q05567 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2675/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:Q05567"", ""source_assertion"": ""UniProtKB:Q05567 has the exact SGD cross-reference SGD:S000002702."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2675/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q05567"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q05567 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_cofactor-685e6c785ff4_94cdfa506268	SGD:S000002469	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40970	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P40970"", ""source_assertion"": ""UniProtKB:P40970 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1788/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P40970"", ""source_assertion"": ""UniProtKB:P40970 has the exact SGD cross-reference SGD:S000002469."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1788/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P40970"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40970 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_cofactor-6bb977ebd95f_ea19c026b362	SGD:S000004911	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P25045	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P25045"", ""source_assertion"": ""UniProtKB:P25045 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/656/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P25045"", ""source_assertion"": ""UniProtKB:P25045 has the exact SGD cross-reference SGD:S000004911."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/656/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P25045"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P25045 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_SPHINGOLIPID-SYN-PWY-1_cofactor-75389e23d89a_e47b553e6ac3	SGD:S000004885	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q03529	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000305 (PubMed:26515067) Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center. UniProt note evidence: ECO:0000269 (PubMed:26515067)	"[{""reference_id"": ""UniProtKB:Q03529"", ""source_assertion"": ""UniProtKB:Q03529 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2509/comments/0/cofactors/0; /results/2509/comments/0/note""}, {""reference_id"": ""UniProtKB:Q03529"", ""source_assertion"": ""UniProtKB:Q03529 has the exact SGD cross-reference SGD:S000004885."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2509/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q03529"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q03529 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MIBiG_BGC0000852_edge-001_7dde3307d9f1	NCBIProtein:AAK12083.1	pathwaymech:enables	MIBiG:BGC0000852	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MIBiG:BGC0000852|NCBIProtein:AAK12083.1	Gene-role assignment follows the deposited similarity annotation. Whole-operon functional support is recorded on the cluster-output edge; individual enzyme activity was not tested.	"[{""reference_id"": ""NCBIProtein:AAK12083.1"", ""source_assertion"": ""AAK12083.1 is annotated as EctA, similar to acetyltransferase, and its CDS is assigned to ectA at AF316874.1:416..958. This is a similarity-based gene-product assignment."", ""source_locator"": ""GBSet/GBSeq[GBSeq_accession-version='AAK12083.1']/GBSeq_feature-table/GBFeature[GBFeature_key='Protein' or GBFeature_key='CDS']/GBFeature_quals""}, {""reference_id"": ""MIBiG:BGC0000852"", ""source_assertion"": ""BGC0000852 identifies AF316874.1 as its locus and ectoine as its product; locus boundaries are unspecified (zero values)."", ""source_locator"": ""$.loci[0].accession; $.loci[0].location; $.compounds[0].name""}]"	"[{""id"": ""MIBiG:BGC0000852"", ""source_sha256"": ""61115740b57cd32f8f98dd10e2c4bb876aa3e445e07ef458b8afaf7cf01ab23d"", ""source_version"": ""MIBiG 4.0; entry version 5"", ""title"": ""MIBiG ectoine cluster BGC0000852, entry version 5"", ""url"": ""https://mibig.secondarymetabolites.org/repository/BGC0000852.5/annotations.json""}, {""id"": ""NCBIProtein:AAK12083.1"", ""source_sha256"": ""cc2c6c9a232cadf29ad33f7a7da80a01abfed2a4a12c9d836532c8e19b6be1c7"", ""source_version"": ""AAK12083.1; AAK12084.1; AAK12085.1 (protein GBSet batch)"", ""title"": ""GenBank AAK12083.1: EctA from Sporosarcina pasteurii"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAK12083.1,AAK12084.1,AAK12085.1&rettype=gb&retmode=xml""}]"	""
pathwaymech:MIBiG_BGC0000852_edge-002_560fbb8448ac	NCBIProtein:AAK12084.1	pathwaymech:enables	MIBiG:BGC0000852	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MIBiG:BGC0000852|NCBIProtein:AAK12084.1	Gene-role assignment follows the deposited similarity annotation. Whole-operon functional support is recorded on the cluster-output edge; individual enzyme activity was not tested.	"[{""reference_id"": ""NCBIProtein:AAK12084.1"", ""source_assertion"": ""AAK12084.1 is annotated as EctB, similar to transaminase, and its CDS is assigned to ectB at AF316874.1:1010..2290. This is a similarity-based gene-product assignment."", ""source_locator"": ""GBSet/GBSeq[GBSeq_accession-version='AAK12084.1']/GBSeq_feature-table/GBFeature[GBFeature_key='Protein' or GBFeature_key='CDS']/GBFeature_quals""}, {""reference_id"": ""MIBiG:BGC0000852"", ""source_assertion"": ""BGC0000852 identifies AF316874.1 as its locus and ectoine as its product; locus boundaries are unspecified (zero values)."", ""source_locator"": ""$.loci[0].accession; $.loci[0].location; $.compounds[0].name""}]"	"[{""id"": ""MIBiG:BGC0000852"", ""source_sha256"": ""61115740b57cd32f8f98dd10e2c4bb876aa3e445e07ef458b8afaf7cf01ab23d"", ""source_version"": ""MIBiG 4.0; entry version 5"", ""title"": ""MIBiG ectoine cluster BGC0000852, entry version 5"", ""url"": ""https://mibig.secondarymetabolites.org/repository/BGC0000852.5/annotations.json""}, {""id"": ""NCBIProtein:AAK12084.1"", ""source_sha256"": ""cc2c6c9a232cadf29ad33f7a7da80a01abfed2a4a12c9d836532c8e19b6be1c7"", ""source_version"": ""AAK12083.1; AAK12084.1; AAK12085.1 (protein GBSet batch)"", ""title"": ""GenBank AAK12084.1: EctB from Sporosarcina pasteurii"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAK12083.1,AAK12084.1,AAK12085.1&rettype=gb&retmode=xml""}]"	""
pathwaymech:MIBiG_BGC0000852_edge-003_8c8681ec72fd	NCBIProtein:AAK12085.1	pathwaymech:enables	MIBiG:BGC0000852	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MIBiG:BGC0000852|NCBIProtein:AAK12085.1	Gene-role assignment follows the deposited similarity annotation. Whole-operon functional support is recorded on the cluster-output edge; individual enzyme activity was not tested.	"[{""reference_id"": ""NCBIProtein:AAK12085.1"", ""source_assertion"": ""AAK12085.1 is annotated as EctC, similar to ectoine synthase, and its CDS is assigned to ectC at AF316874.1:2450..2854. This is a similarity-based gene-product assignment."", ""source_locator"": ""GBSet/GBSeq[GBSeq_accession-version='AAK12085.1']/GBSeq_feature-table/GBFeature[GBFeature_key='Protein' or GBFeature_key='CDS']/GBFeature_quals""}, {""reference_id"": ""MIBiG:BGC0000852"", ""source_assertion"": ""BGC0000852 identifies AF316874.1 as its locus and ectoine as its product; locus boundaries are unspecified (zero values)."", ""source_locator"": ""$.loci[0].accession; $.loci[0].location; $.compounds[0].name""}]"	"[{""id"": ""MIBiG:BGC0000852"", ""source_sha256"": ""61115740b57cd32f8f98dd10e2c4bb876aa3e445e07ef458b8afaf7cf01ab23d"", ""source_version"": ""MIBiG 4.0; entry version 5"", ""title"": ""MIBiG ectoine cluster BGC0000852, entry version 5"", ""url"": ""https://mibig.secondarymetabolites.org/repository/BGC0000852.5/annotations.json""}, {""id"": ""NCBIProtein:AAK12085.1"", ""source_sha256"": ""cc2c6c9a232cadf29ad33f7a7da80a01abfed2a4a12c9d836532c8e19b6be1c7"", ""source_version"": ""AAK12083.1; AAK12084.1; AAK12085.1 (protein GBSet batch)"", ""title"": ""GenBank AAK12085.1: EctC from Sporosarcina pasteurii"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=AAK12083.1,AAK12084.1,AAK12085.1&rettype=gb&retmode=xml""}]"	""
pathwaymech:MIBiG_BGC0000852_edge-004_e034a82ca78d	MIBiG:BGC0000852	pathwaymech:produces	CHEBI:27592	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11823218	Product detected after induced expression of the complete ectABC operon; native-promoter constructs did not produce detectable ectoine in the tested heterologous hosts.	"[{""quote"": ""their heterologous expression in B. subtilis led to the production of ectoine."", ""reference_id"": ""PMID:11823218""}]"	"[{""citation"": ""Kuhlmann AU and Bremer E. Applied and Environmental Microbiology 68:772-783 (2002)."", ""id"": ""PMID:11823218"", ""title"": ""Osmotically Regulated Synthesis of the Compatible Solute Ectoine in Bacillus pasteurii and Related Bacillus spp."", ""url"": ""https://doi.org/10.1128/AEM.68.2.772-783.2002""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-001_407737bce0e2	CHEBI:46911	pathwaymech:consumes	RHEA:11585	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11585		"[{""reference_id"": ""RHEA:11585"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:46911 to its substrates with coefficient 1."", ""source_locator"": ""rh:11585/rh:substrates -> http://rdf.rhea-db.org/11584_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_11584_compound_1826; rh:compound -> http://rdf.rhea-db.org/Compound_1826; rh:chebi""}]"	"[{""id"": ""RHEA:11585"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 11585 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-002_c249cf473eec	RHEA:11585	pathwaymech:produces	CHEBI:57668	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11585		"[{""reference_id"": ""RHEA:11585"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:57668 to its products with coefficient 1."", ""source_locator"": ""rh:11585/rh:products -> http://rdf.rhea-db.org/11584_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_11584_compound_5090; rh:compound -> http://rdf.rhea-db.org/Compound_5090; rh:chebi""}]"	"[{""id"": ""RHEA:11585"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 11585 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-003_b578ef06f5e0	CHEBI:57668	pathwaymech:consumes	RHEA:59137	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59137		"[{""reference_id"": ""RHEA:59137"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:57668 to its substrates with coefficient 1."", ""source_locator"": ""rh:59137/rh:substrates -> http://rdf.rhea-db.org/59136_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59136_compound_5090; rh:compound -> http://rdf.rhea-db.org/Compound_5090; rh:chebi""}]"	"[{""id"": ""RHEA:59137"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59137 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-004_da06caa11006	CHEBI:16947	pathwaymech:consumes	RHEA:59137	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59137		"[{""reference_id"": ""RHEA:59137"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:16947 to its substrates with coefficient 1."", ""source_locator"": ""rh:59137/rh:substrates -> http://rdf.rhea-db.org/59136_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59136_compound_5244; rh:compound -> http://rdf.rhea-db.org/Compound_5244; rh:chebi""}]"	"[{""id"": ""RHEA:59137"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59137 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-005_274cfc1d96fb	CHEBI:30616	pathwaymech:consumes	RHEA:59137	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59137		"[{""reference_id"": ""RHEA:59137"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:30616 to its substrates with coefficient 1."", ""source_locator"": ""rh:59137/rh:substrates -> http://rdf.rhea-db.org/59136_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59136_compound_6372; rh:compound -> http://rdf.rhea-db.org/Compound_6372; rh:chebi""}]"	"[{""id"": ""RHEA:59137"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59137 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-006_b24ef36a72cf	RHEA:59137	pathwaymech:produces	CHEBI:142972	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:142973|RHEA:59137	This edge uses the current Rhea/ChEBI stereospecific free ionic form. The corresponding native MetaCyc compound leaves citryl stereochemistry unspecified; no exact equivalence is asserted.	"[{""reference_id"": ""RHEA:59137"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:142972 to its products with coefficient 1."", ""source_locator"": ""rh:59137/rh:products -> http://rdf.rhea-db.org/59136_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59136_compound_15298; rh:compound -> http://rdf.rhea-db.org/Compound_15298; rh:chebi""}, {""reference_id"": ""CHEBI:142973"", ""source_assertion"": ""CHEBI:142972 defines N(5)-[(S)-citryl]-D-ornithine(2-) with its specified stereochemistry and charge -2. This is the current free chemical identity, distinct from the broader native compound."", ""source_locator"": ""statements[subject=\""CHEBI:142972\"",predicate=rdfs:label|chemrof:inchi_string|chemrof:charge]""}]"	"[{""id"": ""CHEBI:142973"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers full uncompressed original database"", ""title"": ""ChEBI 255 chemical structures, charges and stereochemical names"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""RHEA:59137"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59137 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-007_03b00c684a2b	RHEA:59137	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59137		"[{""reference_id"": ""RHEA:59137"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:456215 to its products with coefficient 1."", ""source_locator"": ""rh:59137/rh:products -> http://rdf.rhea-db.org/59136_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59136_compound_2590; rh:compound -> http://rdf.rhea-db.org/Compound_2590; rh:chebi""}]"	"[{""id"": ""RHEA:59137"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59137 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-008_ffd38768dfca	RHEA:59137	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59137		"[{""reference_id"": ""RHEA:59137"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:33019 to its products with coefficient 1."", ""source_locator"": ""rh:59137/rh:products -> http://rdf.rhea-db.org/59136_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59136_compound_2106; rh:compound -> http://rdf.rhea-db.org/Compound_2106; rh:chebi""}]"	"[{""id"": ""RHEA:59137"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59137 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-009_4f3ec0096313	RHEA:59137	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59137		"[{""reference_id"": ""RHEA:59137"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""rh:59137/rh:products -> http://rdf.rhea-db.org/59136_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59136_compound_3249; rh:compound -> http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:59137"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59137 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-010_6c08c04cb9a8	CHEBI:142972	pathwaymech:consumes	RHEA:59141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:142973|RHEA:59141	This edge uses the current Rhea/ChEBI stereospecific free ionic form. The corresponding native MetaCyc compound leaves citryl stereochemistry unspecified; no exact equivalence is asserted.	"[{""reference_id"": ""RHEA:59141"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:142972 to its substrates with coefficient 1."", ""source_locator"": ""rh:59141/rh:substrates -> http://rdf.rhea-db.org/59140_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59140_compound_15298; rh:compound -> http://rdf.rhea-db.org/Compound_15298; rh:chebi""}, {""reference_id"": ""CHEBI:142973"", ""source_assertion"": ""CHEBI:142972 defines N(5)-[(S)-citryl]-D-ornithine(2-) with its specified stereochemistry and charge -2. This is the current free chemical identity, distinct from the broader native compound."", ""source_locator"": ""statements[subject=\""CHEBI:142972\"",predicate=rdfs:label|chemrof:inchi_string|chemrof:charge]""}]"	"[{""id"": ""CHEBI:142973"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers full uncompressed original database"", ""title"": ""ChEBI 255 chemical structures, charges and stereochemical names"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""RHEA:59141"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59141 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-011_3291ac8dca85	CHEBI:16947	pathwaymech:consumes	RHEA:59141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59141		"[{""reference_id"": ""RHEA:59141"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:16947 to its substrates with coefficient 1."", ""source_locator"": ""rh:59141/rh:substrates -> http://rdf.rhea-db.org/59140_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59140_compound_5244; rh:compound -> http://rdf.rhea-db.org/Compound_5244; rh:chebi""}]"	"[{""id"": ""RHEA:59141"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59141 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-012_38147e696103	CHEBI:30616	pathwaymech:consumes	RHEA:59141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59141		"[{""reference_id"": ""RHEA:59141"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:30616 to its substrates with coefficient 1."", ""source_locator"": ""rh:59141/rh:substrates -> http://rdf.rhea-db.org/59140_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59140_compound_6372; rh:compound -> http://rdf.rhea-db.org/Compound_6372; rh:chebi""}]"	"[{""id"": ""RHEA:59141"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59141 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-013_5ac2abd42710	RHEA:59141	pathwaymech:produces	CHEBI:142973	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:142973|PMID:20147287|RHEA:59141	This edge uses the current Rhea/ChEBI stereospecific free ionic form. The corresponding native MetaCyc compound leaves citryl stereochemistry unspecified; no exact equivalence is asserted.	"[{""reference_id"": ""RHEA:59141"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:142973 to its products with coefficient 1."", ""source_locator"": ""rh:59141/rh:products -> http://rdf.rhea-db.org/59140_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59140_compound_15299; rh:compound -> http://rdf.rhea-db.org/Compound_15299; rh:chebi""}, {""reference_id"": ""CHEBI:142973"", ""source_assertion"": ""CHEBI:142973 defines staphyloferrin A(5-) with its specified stereochemistry and charge -5. This is the current free chemical identity, distinct from the broader native compound."", ""source_locator"": ""statements[subject=\""CHEBI:142973\"",predicate=rdfs:label|chemrof:inchi_string|chemrof:charge]""}, {""reference_id"": ""PMID:20147287"", ""source_assertion"": ""The ferric receptor-bound product model assigns ornithine R and citryl centers N2 R/N5 S; an S,S model fits less well. This supports final product stereochemistry, not a direct free-ion measurement."", ""source_locator"": ""PMC2856993 HTML Results, Structure of Staphyloferrin A (sec18), paragraph 2; Figure 2A-C""}]"	"[{""id"": ""CHEBI:142973"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; digest covers full uncompressed original database"", ""title"": ""ChEBI 255 chemical structures, charges and stereochemical names"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""PMID:20147287"", ""source_sha256"": ""277bab7964e89219a7ddadc88fa289c48583a69b1d57f189960691c8184b353e"", ""source_version"": ""Grigg et al. 2010; complete original PMC HTML inspected; Figure 2A image separately inspected"", ""title"": ""The Staphylococcus aureus Siderophore Receptor HtsA Undergoes Localized Conformational Changes to Enclose Staphyloferrin A in an Arginine-rich Binding Pocket"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2856993/""}, {""id"": ""RHEA:59141"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59141 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-014_708940f9ada9	RHEA:59141	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59141		"[{""reference_id"": ""RHEA:59141"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:456215 to its products with coefficient 1."", ""source_locator"": ""rh:59141/rh:products -> http://rdf.rhea-db.org/59140_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59140_compound_2590; rh:compound -> http://rdf.rhea-db.org/Compound_2590; rh:chebi""}]"	"[{""id"": ""RHEA:59141"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59141 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-015_ef6c064492f1	RHEA:59141	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59141		"[{""reference_id"": ""RHEA:59141"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:33019 to its products with coefficient 1."", ""source_locator"": ""rh:59141/rh:products -> http://rdf.rhea-db.org/59140_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59140_compound_2106; rh:compound -> http://rdf.rhea-db.org/Compound_2106; rh:chebi""}]"	"[{""id"": ""RHEA:59141"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59141 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-016_538acaeaceaf	RHEA:59141	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59141		"[{""reference_id"": ""RHEA:59141"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""rh:59141/rh:products -> http://rdf.rhea-db.org/59140_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59140_compound_3249; rh:compound -> http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:59141"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59141 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-017_1ef76880efe7	RHEA:11585	BFO:0000050	MetaCyc:PWY-7990	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ORNITHINE-RACEMASE-RXN|MetaCyc:PWY-7990|RHEA:11585		"[{""reference_id"": ""MetaCyc:PWY-7990"", ""source_assertion"": ""The complete native pathway explicitly includes ORNITHINE-RACEMASE-RXN; its pathway layout selects the left-to-right biosynthetic direction."", ""source_locator"": ""Pathway[@frameid=\""PWY-7990\""]/reaction-list/Reaction[@frameid=\""ORNITHINE-RACEMASE-RXN\""]; reaction-layout[Reaction/@frameid=\""ORNITHINE-RACEMASE-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:ORNITHINE-RACEMASE-RXN"", ""source_assertion"": ""The native ornithine racemase reaction is reversible and cross-references RHEA:11587. The pathway selects L- to D-ornithine flux."", ""source_locator"": ""Reaction/reaction-direction; dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:11585"", ""source_assertion"": ""Rhea master 11584 links bidirectional 11587 and left-to-right 11585, preserving the explicit direction-family bridge."", ""source_locator"": ""rh:11584/rh:bidirectionalReaction -> rh:11587; rh:directionalReaction -> rh:11585""}]"	"[{""id"": ""MetaCyc:ORNITHINE-RACEMASE-RXN"", ""source_sha256"": ""b6b80a300c6f8e5ebf59cbfbe92b2b9afdce4a0496a2208a180157dbfb61c9a7"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; complete native XML response"", ""title"": ""MetaCyc ORNITHINE-RACEMASE-RXN native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ORNITHINE-RACEMASE-RXN""}, {""id"": ""MetaCyc:PWY-7990"", ""source_sha256"": ""27239c445be00148844a72bc3688743433eba5ab8fd3661119aa0f1481ba1fe5"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; complete native XML response"", ""title"": ""MetaCyc PWY-7990 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7990""}, {""id"": ""RHEA:11585"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 11585 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-018_3e081b46d2f8	RHEA:59137	BFO:0000050	MetaCyc:PWY-7990	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7990|MetaCyc:RXN-19522|RHEA:59137		"[{""reference_id"": ""MetaCyc:PWY-7990"", ""source_assertion"": ""The complete native pathway explicitly includes RXN-19522; its pathway layout selects the left-to-right biosynthetic direction."", ""source_locator"": ""Pathway[@frameid=\""PWY-7990\""]/reaction-list/Reaction[@frameid=\""RXN-19522\""]; reaction-layout[Reaction/@frameid=\""RXN-19522\""]/direction""}, {""reference_id"": ""MetaCyc:RXN-19522"", ""source_assertion"": ""The native equation specifies the ordered citrate ligation with ATP, AMP, diphosphate and proton; its citryl compound identity is less stereospecific than the selected current reaction."", ""source_locator"": ""Reaction/left; right; reaction-direction""}, {""reference_id"": ""RHEA:59137"", ""source_assertion"": ""Current master 59136 links the selected left-to-right direction 59137 and defines the complete stereospecific equation independently of native MetaCyc."", ""source_locator"": ""rh:59136/rh:directionalReaction -> rh:59137; rh:equation""}]"	"[{""id"": ""MetaCyc:PWY-7990"", ""source_sha256"": ""27239c445be00148844a72bc3688743433eba5ab8fd3661119aa0f1481ba1fe5"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; complete native XML response"", ""title"": ""MetaCyc PWY-7990 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7990""}, {""id"": ""MetaCyc:RXN-19522"", ""source_sha256"": ""e8747f2a0cadba4d8790202bcff517b28f39db4e3937d6354543ec9e1f84bc26"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; complete native XML response"", ""title"": ""MetaCyc RXN-19522 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19522""}, {""id"": ""RHEA:59137"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59137 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-019_607a5b6a5d6c	RHEA:59141	BFO:0000050	MetaCyc:PWY-7990	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7990|MetaCyc:RXN-19521|RHEA:59141		"[{""reference_id"": ""MetaCyc:PWY-7990"", ""source_assertion"": ""The complete native pathway explicitly includes RXN-19521; its pathway layout selects the left-to-right biosynthetic direction."", ""source_locator"": ""Pathway[@frameid=\""PWY-7990\""]/reaction-list/Reaction[@frameid=\""RXN-19521\""]; reaction-layout[Reaction/@frameid=\""RXN-19521\""]/direction""}, {""reference_id"": ""MetaCyc:RXN-19521"", ""source_assertion"": ""The native equation specifies the ordered citrate ligation with ATP, AMP, diphosphate and proton; its citryl compound identity is less stereospecific than the selected current reaction."", ""source_locator"": ""Reaction/left; right; reaction-direction""}, {""reference_id"": ""RHEA:59141"", ""source_assertion"": ""Current master 59140 links the selected left-to-right direction 59141 and defines the complete stereospecific equation independently of native MetaCyc."", ""source_locator"": ""rh:59140/rh:directionalReaction -> rh:59141; rh:equation""}]"	"[{""id"": ""MetaCyc:PWY-7990"", ""source_sha256"": ""27239c445be00148844a72bc3688743433eba5ab8fd3661119aa0f1481ba1fe5"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; complete native XML response"", ""title"": ""MetaCyc PWY-7990 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7990""}, {""id"": ""MetaCyc:RXN-19521"", ""source_sha256"": ""549a1c80b1209857e073ebded5aec2080424e6aeae5f9cb81f385cd1d5ad93d0"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; complete native XML response"", ""title"": ""MetaCyc RXN-19521 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19521""}, {""id"": ""RHEA:59141"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59141 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-020_4e3d35b7a913	NCBIProtein:BAF68351.1	pathwaymech:enables	RHEA:11585	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:MONOMER-20490|NCBIProtein:BAF68351.1|PMID:19400778|UniProtKB:Q2FW73	Inferred SfaC gene-product role. Neither exact sequence equality nor whole-locus function demonstrates isolated Newman racemase activity or oligomeric state.	"[{""reference_id"": ""MetaCyc:MONOMER-20490"", ""source_assertion"": ""The native comment explicitly assumes ornithine racemase activity from the functional locus and states that the enzyme was not purified. The mapped UniProt accession is Q2FW73."", ""source_locator"": ""Protein[@frameid=\""MONOMER-20490\""]/comment; dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""NCBIProtein:BAF68351.1"", ""source_assertion"": ""The original Newman entry identifies NWMN_2079 and provides its complete 356-residue sequence; this is genomic protein identity, not a functional assay."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BAF68351.1\""]/GBSeq_feature-table; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q2FW73"", ""source_assertion"": ""The unreviewed NCTC 8325 entry supplies its 356-residue sequence. Comparison with the independently retrieved Newman sequence gives exact equality; functional evidence remains inferred."", ""source_locator"": ""/sequence/value; /organism/taxonId; /entryType""}, {""reference_id"": ""PMID:19400778"", ""source_assertion"": ""Table 2 identifies Newman NWMN_2079 as SfaC by amino-acid-racemase similarity. Locus-level product evidence does not establish purified SfaC catalysis."", ""source_locator"": ""Results, Table 2 (NWMN_2079); Figure 5; original publisher web text""}]"	"[{""id"": ""MetaCyc:MONOMER-20490"", ""source_sha256"": ""958923bf665f3bc0374b9f092e822c05c019fed6ad929211540ba90d4624376c"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; complete native XML response"", ""title"": ""MetaCyc MONOMER-20490 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MONOMER-20490""}, {""id"": ""NCBIProtein:BAF68351.1"", ""source_sha256"": ""2fdc00fa0a7a74f5da04f405586e84f23d0ecb26fa67d858dfc27bd46a3d73b7"", ""source_version"": ""GenPept original three-entry batch retrieved 2026-10-11; hash covers entire XML batch"", ""title"": ""NCBI GenPept BAF68351.1 Newman protein identity"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAF68351,BAF68352,BAF68354&rettype=gb&retmode=xml""}, {""id"": ""PMID:19400778"", ""source_version"": ""Beasley et al. 2009; full original publisher text inspected through web access on 2026-10-11; no local full-body hash; indexed abstract separately retained"", ""title"": ""Characterization of staphyloferrin A biosynthetic and transport mutants in Staphylococcus aureus."", ""url"": ""https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2009.06698.x""}, {""id"": ""UniProtKB:Q2FW73"", ""source_sha256"": ""7fceaf99fc2b16e6887e72183a07fb01ae823e45081cdd79c9e73c7a1dd52f37"", ""source_version"": ""UniProt release 2026_03; original JSON retrieved 2026-10-11"", ""title"": ""UniProtKB Q2FW73 original entry; NCTC 8325 scope"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q2FW73.json""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-021_d6314c897945	NCBIProtein:BAF68354.1	pathwaymech:enables	RHEA:59137	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BAF68354.1|PMID:19138128|PMID:20147287|UniProtKB:Q2FW70	The Newman sequence differs from Q2FW70 at residue 532; exact identity is not claimed. SfaD functional role supported by Newman recombinant biosynthesis plus independently ordered ligation evidence. Exact engineered sequences and native oligomeric sufficiency remain unresolved.	"[{""reference_id"": ""NCBIProtein:BAF68354.1"", ""source_assertion"": ""The versioned entry identifies the Newman coding product, locus and complete protein sequence. Comparison with NCTC 8325 is a separate curation calculation."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BAF68354.1\""]/GBSeq_feature-table; GBSeq_sequence""}, {""reference_id"": ""PMID:20147287"", ""source_assertion"": ""The study used Newman sfaB and sfaD coding regions for recombinant protein preparations and jointly synthesized staphyloferrin A. This supports the Newman implementation but does not resolve native assemblies."", ""source_locator"": ""PMC2856993 HTML Experimental Procedures, Cloning and Protein Expression (sec5), paragraph 2; Staphyloferrin A Synthesis and Purification (sec7)""}, {""reference_id"": ""PMID:19138128"", ""source_assertion"": ""The inspected abstract assigns the first delta-amine citrate ligation to SfnaD and the terminal alpha-amine ligation to SfnaB. Full methods and exact Cotton construct sequences were not inspected."", ""source_locator"": ""Europe PMC core resultList.result[0].abstractText""}, {""reference_id"": ""UniProtKB:Q2FW70"", ""source_assertion"": ""The reviewed NCTC 8325 entry assigns this reaction and left-to-right physiological direction with ECO:0000269 citing Cotton. This source annotation is kept separate from Newman protein identity."", ""source_locator"": ""/comments/1/reaction; /comments/1/physiologicalReactions; /organism/taxonId""}, {""reference_id"": ""UniProtKB:Q2FW70"", ""source_assertion"": ""The current entry provides the complete NCTC 8325 protein sequence. This supplies the independent comparison source, not an assertion that Newman and NCTC 8325 are the same strain."", ""source_locator"": ""/sequence/value; /organism/taxonId""}]"	"[{""id"": ""NCBIProtein:BAF68354.1"", ""source_sha256"": ""2fdc00fa0a7a74f5da04f405586e84f23d0ecb26fa67d858dfc27bd46a3d73b7"", ""source_version"": ""GenPept original three-entry batch retrieved 2026-10-11; hash covers entire XML batch"", ""title"": ""NCBI GenPept BAF68354.1 Newman protein identity"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAF68351,BAF68352,BAF68354&rettype=gb&retmode=xml""}, {""id"": ""PMID:19138128"", ""source_sha256"": ""e5b698d300fb2e11e542599924d67fdf37a1e9e3dced460a480128bbe39b38a3"", ""source_version"": ""Cotton et al. 2009; indexed abstract only; hash covers original Europe PMC core JSON, not full article"", ""title"": ""Identification and characterization of the Staphylococcus aureus gene cluster coding for staphyloferrin A."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19138128&resultType=core&format=json""}, {""id"": ""PMID:20147287"", ""source_sha256"": ""277bab7964e89219a7ddadc88fa289c48583a69b1d57f189960691c8184b353e"", ""source_version"": ""Grigg et al. 2010; complete original PMC HTML inspected; Figure 2A image separately inspected"", ""title"": ""The Staphylococcus aureus Siderophore Receptor HtsA Undergoes Localized Conformational Changes to Enclose Staphyloferrin A in an Arginine-rich Binding Pocket"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2856993/""}, {""id"": ""UniProtKB:Q2FW70"", ""source_sha256"": ""6cef6c15a0631af86ff9dfb54c4f495be0cbdfd9702ed0a92c8c6bafeb1ddf20"", ""source_version"": ""UniProt release 2026_03; original JSON retrieved 2026-10-11"", ""title"": ""UniProtKB Q2FW70 original entry; NCTC 8325 scope"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q2FW70.json""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-022_2f91ae215859	NCBIProtein:BAF68352.1	pathwaymech:enables	RHEA:59141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BAF68352.1|PMID:19138128|PMID:20147287|UniProtKB:Q2FW72	The Newman sequence is identical to Q2FW72; strain provenance still remains distinct. SfaB functional role supported by Newman recombinant biosynthesis plus independently ordered ligation evidence. Exact engineered sequences and native oligomeric sufficiency remain unresolved.	"[{""reference_id"": ""NCBIProtein:BAF68352.1"", ""source_assertion"": ""The versioned entry identifies the Newman coding product, locus and complete protein sequence. Comparison with NCTC 8325 is a separate curation calculation."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BAF68352.1\""]/GBSeq_feature-table; GBSeq_sequence""}, {""reference_id"": ""PMID:20147287"", ""source_assertion"": ""The study used Newman sfaB and sfaD coding regions for recombinant protein preparations and jointly synthesized staphyloferrin A. This supports the Newman implementation but does not resolve native assemblies."", ""source_locator"": ""PMC2856993 HTML Experimental Procedures, Cloning and Protein Expression (sec5), paragraph 2; Staphyloferrin A Synthesis and Purification (sec7)""}, {""reference_id"": ""PMID:19138128"", ""source_assertion"": ""The inspected abstract assigns the first delta-amine citrate ligation to SfnaD and the terminal alpha-amine ligation to SfnaB. Full methods and exact Cotton construct sequences were not inspected."", ""source_locator"": ""Europe PMC core resultList.result[0].abstractText""}, {""reference_id"": ""UniProtKB:Q2FW72"", ""source_assertion"": ""The reviewed NCTC 8325 entry assigns this reaction and left-to-right physiological direction with ECO:0000269 citing Cotton. This source annotation is kept separate from Newman protein identity."", ""source_locator"": ""/comments/1/reaction; /comments/1/physiologicalReactions; /organism/taxonId""}, {""reference_id"": ""UniProtKB:Q2FW72"", ""source_assertion"": ""The current entry provides the complete NCTC 8325 protein sequence. This supplies the independent comparison source, not an assertion that Newman and NCTC 8325 are the same strain."", ""source_locator"": ""/sequence/value; /organism/taxonId""}]"	"[{""id"": ""NCBIProtein:BAF68352.1"", ""source_sha256"": ""2fdc00fa0a7a74f5da04f405586e84f23d0ecb26fa67d858dfc27bd46a3d73b7"", ""source_version"": ""GenPept original three-entry batch retrieved 2026-10-11; hash covers entire XML batch"", ""title"": ""NCBI GenPept BAF68352.1 Newman protein identity"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAF68351,BAF68352,BAF68354&rettype=gb&retmode=xml""}, {""id"": ""PMID:19138128"", ""source_sha256"": ""e5b698d300fb2e11e542599924d67fdf37a1e9e3dced460a480128bbe39b38a3"", ""source_version"": ""Cotton et al. 2009; indexed abstract only; hash covers original Europe PMC core JSON, not full article"", ""title"": ""Identification and characterization of the Staphylococcus aureus gene cluster coding for staphyloferrin A."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19138128&resultType=core&format=json""}, {""id"": ""PMID:20147287"", ""source_sha256"": ""277bab7964e89219a7ddadc88fa289c48583a69b1d57f189960691c8184b353e"", ""source_version"": ""Grigg et al. 2010; complete original PMC HTML inspected; Figure 2A image separately inspected"", ""title"": ""The Staphylococcus aureus Siderophore Receptor HtsA Undergoes Localized Conformational Changes to Enclose Staphyloferrin A in an Arginine-rich Binding Pocket"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2856993/""}, {""id"": ""UniProtKB:Q2FW72"", ""source_sha256"": ""dd93f4b989908117d6a8a118858c7542790be643817013ca65ea395a2d07d854"", ""source_version"": ""UniProt release 2026_03; original JSON retrieved 2026-10-11"", ""title"": ""UniProtKB Q2FW72 original entry; NCTC 8325 scope"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q2FW72.json""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-023_f6823250959a	NCBIProtein:BAF68351.1	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BAF68351.1|UniProtKB:Q2FW73	Automatic cofactor inference transferred through exact sequence equality; no binding count or direct Newman measurement is asserted.	"[{""reference_id"": ""UniProtKB:Q2FW73"", ""source_assertion"": ""The unreviewed NCTC 8325 entry assigns pyridoxal 5-prime-phosphate (CHEBI:597326) through automatic ARBA evidence ECO:0000256; it is not a direct cofactor experiment."", ""source_locator"": ""/comments/0/cofactors/0/cofactorCrossReference; /comments/0/cofactors/0/evidences/0; /sequence/value""}, {""reference_id"": ""NCBIProtein:BAF68351.1"", ""source_assertion"": ""The selected entry provides the complete Newman protein sequence. Its identity and genomic origin do not independently establish cofactor binding."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BAF68351.1\""]/GBSeq_sequence""}]"	"[{""id"": ""NCBIProtein:BAF68351.1"", ""source_sha256"": ""2fdc00fa0a7a74f5da04f405586e84f23d0ecb26fa67d858dfc27bd46a3d73b7"", ""source_version"": ""GenPept original three-entry batch retrieved 2026-10-11; hash covers entire XML batch"", ""title"": ""NCBI GenPept BAF68351.1 Newman protein identity"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAF68351,BAF68352,BAF68354&rettype=gb&retmode=xml""}, {""id"": ""UniProtKB:Q2FW73"", ""source_sha256"": ""7fceaf99fc2b16e6887e72183a07fb01ae823e45081cdd79c9e73c7a1dd52f37"", ""source_version"": ""UniProt release 2026_03; original JSON retrieved 2026-10-11"", ""title"": ""UniProtKB Q2FW73 original entry; NCTC 8325 scope"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q2FW73.json""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-024_ba2e8724f683	NCBIProtein:BAF68352.1	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-26283|PMID:20147287	Qualified native ligase cofactor assignment applied to the Newman role; no independently measured Newman metal specificity, binding stoichiometry or metal-exclusive requirement is claimed.	"[{""reference_id"": ""MetaCyc:ENZRXN-26283"", ""source_assertion"": ""The native ligase enzymatic-reaction object explicitly lists MG+2 as cofactor and cites Cotton. The cited full article was unavailable; this is a curated database assertion rather than an independently inspected metal assay."", ""source_locator"": ""Enzymatic-Reaction[@frameid=\""ENZRXN-26283\""]/cofactor/Compound[@frameid=\""MG+2\""]; cofactor/citation""}, {""reference_id"": ""PMID:20147287"", ""source_assertion"": ""The complete article identifies Newman SfaB and SfaD recombinant preparations used in joint biosynthesis. It supports the selected implementation, not a unique physiological metal or binding stoichiometry."", ""source_locator"": ""PMC2856993 HTML sec5 paragraph 2; sec7""}]"	"[{""id"": ""MetaCyc:ENZRXN-26283"", ""source_sha256"": ""ce4d7f29a7a563118e9603c643b0c8782a8bf17367cce15682eb7fabc12c1730"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; complete native XML response"", ""title"": ""MetaCyc ENZRXN-26283 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-26283""}, {""id"": ""PMID:20147287"", ""source_sha256"": ""277bab7964e89219a7ddadc88fa289c48583a69b1d57f189960691c8184b353e"", ""source_version"": ""Grigg et al. 2010; complete original PMC HTML inspected; Figure 2A image separately inspected"", ""title"": ""The Staphylococcus aureus Siderophore Receptor HtsA Undergoes Localized Conformational Changes to Enclose Staphyloferrin A in an Arginine-rich Binding Pocket"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2856993/""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-025_4de027131e3b	NCBIProtein:BAF68354.1	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-26284|PMID:20147287	Qualified native ligase cofactor assignment applied to the Newman role; no independently measured Newman metal specificity, binding stoichiometry or metal-exclusive requirement is claimed.	"[{""reference_id"": ""MetaCyc:ENZRXN-26284"", ""source_assertion"": ""The native ligase enzymatic-reaction object explicitly lists MG+2 as cofactor and cites Cotton. The cited full article was unavailable; this is a curated database assertion rather than an independently inspected metal assay."", ""source_locator"": ""Enzymatic-Reaction[@frameid=\""ENZRXN-26284\""]/cofactor/Compound[@frameid=\""MG+2\""]; cofactor/citation""}, {""reference_id"": ""PMID:20147287"", ""source_assertion"": ""The complete article identifies Newman SfaB and SfaD recombinant preparations used in joint biosynthesis. It supports the selected implementation, not a unique physiological metal or binding stoichiometry."", ""source_locator"": ""PMC2856993 HTML sec5 paragraph 2; sec7""}]"	"[{""id"": ""MetaCyc:ENZRXN-26284"", ""source_sha256"": ""6525b654efb61af177de919ec96d0e877016bd6e1c22941aadce2c3de5d29e9b"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; complete native XML response"", ""title"": ""MetaCyc ENZRXN-26284 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-26284""}, {""id"": ""PMID:20147287"", ""source_sha256"": ""277bab7964e89219a7ddadc88fa289c48583a69b1d57f189960691c8184b353e"", ""source_version"": ""Grigg et al. 2010; complete original PMC HTML inspected; Figure 2A image separately inspected"", ""title"": ""The Staphylococcus aureus Siderophore Receptor HtsA Undergoes Localized Conformational Changes to Enclose Staphyloferrin A in an Arginine-rich Binding Pocket"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2856993/""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-026_41f87c4c84ed	NCBIProtein:BAF68351.1	BFO:0000050	NCBITaxon:426430	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BAF68351.1		"[{""reference_id"": ""NCBIProtein:BAF68351.1"", ""source_assertion"": ""The source feature explicitly identifies strain Newman and taxon 426430 for this versioned protein."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BAF68351.1\""]/GBSeq_feature-table/GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}]"	"[{""id"": ""NCBIProtein:BAF68351.1"", ""source_sha256"": ""2fdc00fa0a7a74f5da04f405586e84f23d0ecb26fa67d858dfc27bd46a3d73b7"", ""source_version"": ""GenPept original three-entry batch retrieved 2026-10-11; hash covers entire XML batch"", ""title"": ""NCBI GenPept BAF68351.1 Newman protein identity"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAF68351,BAF68352,BAF68354&rettype=gb&retmode=xml""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-027_efc8ec8c3e04	NCBIProtein:BAF68352.1	BFO:0000050	NCBITaxon:426430	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BAF68352.1		"[{""reference_id"": ""NCBIProtein:BAF68352.1"", ""source_assertion"": ""The source feature explicitly identifies strain Newman and taxon 426430 for this versioned protein."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BAF68352.1\""]/GBSeq_feature-table/GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}]"	"[{""id"": ""NCBIProtein:BAF68352.1"", ""source_sha256"": ""2fdc00fa0a7a74f5da04f405586e84f23d0ecb26fa67d858dfc27bd46a3d73b7"", ""source_version"": ""GenPept original three-entry batch retrieved 2026-10-11; hash covers entire XML batch"", ""title"": ""NCBI GenPept BAF68352.1 Newman protein identity"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAF68351,BAF68352,BAF68354&rettype=gb&retmode=xml""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-028_58efd28f3842	NCBIProtein:BAF68354.1	BFO:0000050	NCBITaxon:426430	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BAF68354.1		"[{""reference_id"": ""NCBIProtein:BAF68354.1"", ""source_assertion"": ""The source feature explicitly identifies strain Newman and taxon 426430 for this versioned protein."", ""source_locator"": ""GBSeq[GBSeq_accession-version=\""BAF68354.1\""]/GBSeq_feature-table/GBFeature[GBFeature_key=\""source\""]/GBFeature_quals""}]"	"[{""id"": ""NCBIProtein:BAF68354.1"", ""source_sha256"": ""2fdc00fa0a7a74f5da04f405586e84f23d0ecb26fa67d858dfc27bd46a3d73b7"", ""source_version"": ""GenPept original three-entry batch retrieved 2026-10-11; hash covers entire XML batch"", ""title"": ""NCBI GenPept BAF68354.1 Newman protein identity"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAF68351,BAF68352,BAF68354&rettype=gb&retmode=xml""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-029_15d4d63f64a0	MetaCyc:PWY-7990	BFO:0000050	NCBITaxon:426430	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19400778		"[{""reference_id"": ""PMID:19400778"", ""source_assertion"": ""The Newman locus and product analyses support staphyloferrin A biosynthesis; these organism-level observations do not independently assay every encoded activity."", ""source_locator"": ""Results, The NWMN_2082-2079 locus mediates staphyloferrin A biosynthesis; Figure 5; original publisher web text""}]"	"[{""id"": ""PMID:19400778"", ""source_version"": ""Beasley et al. 2009; full original publisher text inspected through web access on 2026-10-11; no local full-body hash; indexed abstract separately retained"", ""title"": ""Characterization of staphyloferrin A biosynthetic and transport mutants in Staphylococcus aureus."", ""url"": ""https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2009.06698.x""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-030_f9598396a7e9	RHEA:11585	RO:0002413	RHEA:59137	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7990|RHEA:11585|RHEA:59137		"[{""reference_id"": ""MetaCyc:PWY-7990"", ""source_assertion"": ""The native ordering puts ORNITHINE-RACEMASE-RXN before RXN-19522; native frames define the shared intermediate without a ChEBI equivalence claim."", ""source_locator"": ""Pathway/reaction-ordering[Reaction/@frameid=\""RXN-19522\""]/predecessor-reactions""}, {""reference_id"": ""RHEA:11585"", ""source_assertion"": ""The selected upstream direction produces CHEBI:57668, the same chemical identity independently consumed by the selected downstream direction."", ""source_locator"": ""rh:11585/rh:products -> side/rh:contains1 -> participant/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:59137"", ""source_assertion"": ""The selected downstream direction consumes CHEBI:57668; the explicit common chemical supports material continuity."", ""source_locator"": ""rh:59137/rh:substrates -> side/rh:contains1 -> participant/rh:compound/rh:chebi""}]"	"[{""id"": ""MetaCyc:PWY-7990"", ""source_sha256"": ""27239c445be00148844a72bc3688743433eba5ab8fd3661119aa0f1481ba1fe5"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; complete native XML response"", ""title"": ""MetaCyc PWY-7990 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7990""}, {""id"": ""RHEA:11585"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 11585 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:59137"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59137 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7990_sfa-edge-031_170790e31737	RHEA:59137	RO:0002413	RHEA:59141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7990|RHEA:59137|RHEA:59141		"[{""reference_id"": ""MetaCyc:PWY-7990"", ""source_assertion"": ""The native ordering puts RXN-19522 before RXN-19521; native frames define the shared intermediate without a ChEBI equivalence claim."", ""source_locator"": ""Pathway/reaction-ordering[Reaction/@frameid=\""RXN-19521\""]/predecessor-reactions""}, {""reference_id"": ""RHEA:59137"", ""source_assertion"": ""The selected upstream direction produces CHEBI:142972, the same chemical identity independently consumed by the selected downstream direction."", ""source_locator"": ""rh:59137/rh:products -> side/rh:contains1 -> participant/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:59141"", ""source_assertion"": ""The selected downstream direction consumes CHEBI:142972; the explicit common chemical supports material continuity."", ""source_locator"": ""rh:59141/rh:substrates -> side/rh:contains1 -> participant/rh:compound/rh:chebi""}]"	"[{""id"": ""MetaCyc:PWY-7990"", ""source_sha256"": ""27239c445be00148844a72bc3688743433eba5ab8fd3661119aa0f1481ba1fe5"", ""source_version"": ""MetaCyc 22.5; retrieved 2026-10-11; complete native XML response"", ""title"": ""MetaCyc PWY-7990 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7990""}, {""id"": ""RHEA:59137"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59137 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:59141"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete original gzip RDF"", ""title"": ""Rhea 59141 exact directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-001_e21de2bd4b90	CHEBI:33384	pathwaymech:consumes	RHEA:59113	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59113		"[{""reference_id"": ""RHEA:59113"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:33384 to substrates with coefficient 1."", ""source_locator"": ""rh:59113/rh:substrates -> http://rdf.rhea-db.org/59112_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59112_compound_4901; rh:compound -> http://rdf.rhea-db.org/Compound_4901; rh:chebi""}]"	"[{""id"": ""RHEA:59113"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59113 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-002_634abecc632f	CHEBI:30616	pathwaymech:consumes	RHEA:59113	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59113		"[{""reference_id"": ""RHEA:59113"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:30616 to substrates with coefficient 1."", ""source_locator"": ""rh:59113/rh:substrates -> http://rdf.rhea-db.org/59112_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59112_compound_6372; rh:compound -> http://rdf.rhea-db.org/Compound_6372; rh:chebi""}]"	"[{""id"": ""RHEA:59113"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59113 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-003_8ec3bfc37ed3	RHEA:59113	pathwaymech:produces	CHEBI:57524	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59113		"[{""reference_id"": ""RHEA:59113"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:57524 to products with coefficient 1."", ""source_locator"": ""rh:59113/rh:products -> http://rdf.rhea-db.org/59112_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59112_compound_1236; rh:compound -> http://rdf.rhea-db.org/Compound_1236; rh:chebi""}]"	"[{""id"": ""RHEA:59113"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59113 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-004_8e732310e9c2	RHEA:59113	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59113		"[{""reference_id"": ""RHEA:59113"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:456216 to products with coefficient 1."", ""source_locator"": ""rh:59113/rh:products -> http://rdf.rhea-db.org/59112_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59112_compound_2710; rh:compound -> http://rdf.rhea-db.org/Compound_2710; rh:chebi""}]"	"[{""id"": ""RHEA:59113"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59113 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-005_c212ff359eed	RHEA:59113	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59113		"[{""reference_id"": ""RHEA:59113"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:15378 to products with coefficient 1."", ""source_locator"": ""rh:59113/rh:products -> http://rdf.rhea-db.org/59112_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59112_compound_3249; rh:compound -> http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:59113"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59113 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-006_d3006acf06a4	CHEBI:57524	pathwaymech:consumes	RHEA:52385	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:52385		"[{""reference_id"": ""RHEA:52385"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:57524 to substrates with coefficient 1."", ""source_locator"": ""rh:52385/rh:substrates -> http://rdf.rhea-db.org/52384_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_52384_compound_1236; rh:compound -> http://rdf.rhea-db.org/Compound_1236; rh:chebi""}]"	"[{""id"": ""RHEA:52385"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:52385 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-007_17eaba92f3ac	CHEBI:29985	pathwaymech:consumes	RHEA:52385	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:52385		"[{""reference_id"": ""RHEA:52385"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:29985 to substrates with coefficient 1."", ""source_locator"": ""rh:52385/rh:substrates -> http://rdf.rhea-db.org/52384_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_52384_compound_2079; rh:compound -> http://rdf.rhea-db.org/Compound_2079; rh:chebi""}]"	"[{""id"": ""RHEA:52385"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:52385 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-008_40af05511064	RHEA:52385	pathwaymech:produces	CHEBI:134610	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:52385		"[{""reference_id"": ""RHEA:52385"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:134610 to products with coefficient 1."", ""source_locator"": ""rh:52385/rh:products -> http://rdf.rhea-db.org/52384_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_52384_compound_13099; rh:compound -> http://rdf.rhea-db.org/Compound_13099; rh:chebi""}]"	"[{""id"": ""RHEA:52385"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:52385 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-009_3cf7f726aa16	RHEA:52385	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:52385		"[{""reference_id"": ""RHEA:52385"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:43474 to products with coefficient 1."", ""source_locator"": ""rh:52385/rh:products -> http://rdf.rhea-db.org/52384_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_52384_compound_5518; rh:compound -> http://rdf.rhea-db.org/Compound_5518; rh:chebi""}]"	"[{""id"": ""RHEA:52385"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:52385 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-010_7c1e237af976	RHEA:52385	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:52385		"[{""reference_id"": ""RHEA:52385"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:15378 to products with coefficient 1."", ""source_locator"": ""rh:52385/rh:products -> http://rdf.rhea-db.org/52384_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_52384_compound_3249; rh:compound -> http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:52385"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:52385 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-011_78edf8ec535d	CHEBI:134610	pathwaymech:consumes	RHEA:51929	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51929		"[{""reference_id"": ""RHEA:51929"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:134610 to substrates with coefficient 1."", ""source_locator"": ""rh:51929/rh:substrates -> http://rdf.rhea-db.org/51928_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_51928_compound_13099; rh:compound -> http://rdf.rhea-db.org/Compound_13099; rh:chebi""}]"	"[{""id"": ""RHEA:51929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:51929 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-012_877fa316e533	CHEBI:57540	pathwaymech:consumes	RHEA:51929	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51929		"[{""reference_id"": ""RHEA:51929"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:57540 to substrates with coefficient 1."", ""source_locator"": ""rh:51929/rh:substrates -> http://rdf.rhea-db.org/51928_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_51928_compound_3484; rh:compound -> http://rdf.rhea-db.org/Compound_3484; rh:chebi""}]"	"[{""id"": ""RHEA:51929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:51929 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-013_3489dabce0df	CHEBI:15377	pathwaymech:consumes	RHEA:51929	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51929		"[{""reference_id"": ""RHEA:51929"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:15377 to substrates with coefficient 1."", ""source_locator"": ""rh:51929/rh:substrates -> http://rdf.rhea-db.org/51928_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_51928_compound_1283; rh:compound -> http://rdf.rhea-db.org/Compound_1283; rh:chebi""}]"	"[{""id"": ""RHEA:51929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:51929 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-014_95d6b8f017ba	RHEA:51929	pathwaymech:produces	CHEBI:57721	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51929		"[{""reference_id"": ""RHEA:51929"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:57721 to products with coefficient 1."", ""source_locator"": ""rh:51929/rh:products -> http://rdf.rhea-db.org/51928_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_51928_compound_1905; rh:compound -> http://rdf.rhea-db.org/Compound_1905; rh:chebi""}]"	"[{""id"": ""RHEA:51929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:51929 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-015_9b290a38f8ac	RHEA:51929	pathwaymech:produces	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51929		"[{""reference_id"": ""RHEA:51929"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:16810 to products with coefficient 1."", ""source_locator"": ""rh:51929/rh:products -> http://rdf.rhea-db.org/51928_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_51928_compound_2975; rh:compound -> http://rdf.rhea-db.org/Compound_2975; rh:chebi""}]"	"[{""id"": ""RHEA:51929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:51929 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-016_1fd65d57472e	RHEA:51929	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51929		"[{""reference_id"": ""RHEA:51929"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:57945 to products with coefficient 1."", ""source_locator"": ""rh:51929/rh:products -> http://rdf.rhea-db.org/51928_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_51928_compound_1650; rh:compound -> http://rdf.rhea-db.org/Compound_1650; rh:chebi""}]"	"[{""id"": ""RHEA:51929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:51929 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-017_8737adb8735d	RHEA:51929	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51929		"[{""reference_id"": ""RHEA:51929"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:15378 to products with coefficient 1."", ""source_locator"": ""rh:51929/rh:products -> http://rdf.rhea-db.org/51928_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_51928_compound_3249; rh:compound -> http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:51929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:51929 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-018_086a18520545	CHEBI:57721	pathwaymech:consumes	RHEA:59125	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59125		"[{""reference_id"": ""RHEA:59125"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:57721 to substrates with coefficient 1."", ""source_locator"": ""rh:59125/rh:substrates -> http://rdf.rhea-db.org/59124_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59124_compound_1905; rh:compound -> http://rdf.rhea-db.org/Compound_1905; rh:chebi""}]"	"[{""id"": ""RHEA:59125"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59125 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-019_c6fcad61886c	CHEBI:16947	pathwaymech:consumes	RHEA:59125	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59125		"[{""reference_id"": ""RHEA:59125"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:16947 to substrates with coefficient 1."", ""source_locator"": ""rh:59125/rh:substrates -> http://rdf.rhea-db.org/59124_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59124_compound_5244; rh:compound -> http://rdf.rhea-db.org/Compound_5244; rh:chebi""}]"	"[{""id"": ""RHEA:59125"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59125 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-020_9e95b7b48079	CHEBI:30616	pathwaymech:consumes	RHEA:59125	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59125		"[{""reference_id"": ""RHEA:59125"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:30616 to substrates with coefficient 1."", ""source_locator"": ""rh:59125/rh:substrates -> http://rdf.rhea-db.org/59124_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59124_compound_6372; rh:compound -> http://rdf.rhea-db.org/Compound_6372; rh:chebi""}]"	"[{""id"": ""RHEA:59125"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59125 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-021_a9971798e411	RHEA:59125	pathwaymech:produces	CHEBI:142969	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:136993|RHEA:59125		"[{""reference_id"": ""RHEA:59125"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:142969 to products with coefficient 1."", ""source_locator"": ""rh:59125/rh:products -> http://rdf.rhea-db.org/59124_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59124_compound_15297; rh:compound -> http://rdf.rhea-db.org/Compound_15297; rh:chebi""}, {""reference_id"": ""CHEBI:136993"", ""source_assertion"": ""The selected ChEBI structure specifies the citryl center; this is a current chemical-authority convention, not a direct stereochemical assay on this Newman intermediate."", ""source_locator"": ""Semantic SQL CHEBI:142969/chemrof:inchi_string; rdfs:label""}]"	"[{""id"": ""CHEBI:136993"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; hash covers full uncompressed original database"", ""title"": ""ChEBI 255 formal chemical structures and charge states"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""RHEA:59125"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59125 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-022_a45e3a2ec0a5	RHEA:59125	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59125		"[{""reference_id"": ""RHEA:59125"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:456215 to products with coefficient 1."", ""source_locator"": ""rh:59125/rh:products -> http://rdf.rhea-db.org/59124_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59124_compound_2590; rh:compound -> http://rdf.rhea-db.org/Compound_2590; rh:chebi""}]"	"[{""id"": ""RHEA:59125"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59125 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-023_ce2d5b0c55aa	RHEA:59125	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59125		"[{""reference_id"": ""RHEA:59125"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:33019 to products with coefficient 1."", ""source_locator"": ""rh:59125/rh:products -> http://rdf.rhea-db.org/59124_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59124_compound_2106; rh:compound -> http://rdf.rhea-db.org/Compound_2106; rh:chebi""}]"	"[{""id"": ""RHEA:59125"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59125 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-024_3da2e6b5115a	CHEBI:142969	pathwaymech:consumes	RHEA:59121	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:136993|RHEA:59121		"[{""reference_id"": ""RHEA:59121"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:142969 to substrates with coefficient 1."", ""source_locator"": ""rh:59121/rh:substrates -> http://rdf.rhea-db.org/59120_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59120_compound_15297; rh:compound -> http://rdf.rhea-db.org/Compound_15297; rh:chebi""}, {""reference_id"": ""CHEBI:136993"", ""source_assertion"": ""The selected ChEBI structure specifies the citryl center; this is a current chemical-authority convention, not a direct stereochemical assay on this Newman intermediate."", ""source_locator"": ""Semantic SQL CHEBI:142969/chemrof:inchi_string; rdfs:label""}]"	"[{""id"": ""CHEBI:136993"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; hash covers full uncompressed original database"", ""title"": ""ChEBI 255 formal chemical structures and charge states"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""RHEA:59121"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59121 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-025_636382977425	CHEBI:15378	pathwaymech:consumes	RHEA:59121	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59121		"[{""reference_id"": ""RHEA:59121"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:15378 to substrates with coefficient 1."", ""source_locator"": ""rh:59121/rh:substrates -> http://rdf.rhea-db.org/59120_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59120_compound_3249; rh:compound -> http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:59121"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59121 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-026_f7c8bc71916f	RHEA:59121	pathwaymech:produces	CHEBI:142970	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:136993|RHEA:59121		"[{""reference_id"": ""RHEA:59121"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:142970 to products with coefficient 1."", ""source_locator"": ""rh:59121/rh:products -> http://rdf.rhea-db.org/59120_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59120_compound_15295; rh:compound -> http://rdf.rhea-db.org/Compound_15295; rh:chebi""}, {""reference_id"": ""CHEBI:136993"", ""source_assertion"": ""The selected ChEBI structure specifies the citryl center; this is a current chemical-authority convention, not a direct stereochemical assay on this Newman intermediate."", ""source_locator"": ""Semantic SQL CHEBI:142970/chemrof:inchi_string; rdfs:label""}]"	"[{""id"": ""CHEBI:136993"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; hash covers full uncompressed original database"", ""title"": ""ChEBI 255 formal chemical structures and charge states"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""RHEA:59121"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59121 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-027_57ff44402a8e	RHEA:59121	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59121		"[{""reference_id"": ""RHEA:59121"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:16526 to products with coefficient 1."", ""source_locator"": ""rh:59121/rh:products -> http://rdf.rhea-db.org/59120_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59120_compound_4391; rh:compound -> http://rdf.rhea-db.org/Compound_4391; rh:chebi""}]"	"[{""id"": ""RHEA:59121"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59121 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-028_9af0ba3e593a	CHEBI:142970	pathwaymech:consumes	RHEA:59129	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:136993|RHEA:59129		"[{""reference_id"": ""RHEA:59129"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:142970 to substrates with coefficient 1."", ""source_locator"": ""rh:59129/rh:substrates -> http://rdf.rhea-db.org/59128_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59128_compound_15295; rh:compound -> http://rdf.rhea-db.org/Compound_15295; rh:chebi""}, {""reference_id"": ""CHEBI:136993"", ""source_assertion"": ""The selected ChEBI structure specifies the citryl center; this is a current chemical-authority convention, not a direct stereochemical assay on this Newman intermediate."", ""source_locator"": ""Semantic SQL CHEBI:142970/chemrof:inchi_string; rdfs:label""}]"	"[{""id"": ""CHEBI:136993"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; hash covers full uncompressed original database"", ""title"": ""ChEBI 255 formal chemical structures and charge states"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""RHEA:59129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59129 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-029_d35a71f56e3a	CHEBI:57721	pathwaymech:consumes	RHEA:59129	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59129		"[{""reference_id"": ""RHEA:59129"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:57721 to substrates with coefficient 1."", ""source_locator"": ""rh:59129/rh:substrates -> http://rdf.rhea-db.org/59128_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59128_compound_1905; rh:compound -> http://rdf.rhea-db.org/Compound_1905; rh:chebi""}]"	"[{""id"": ""RHEA:59129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59129 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-030_53542a038d09	CHEBI:30616	pathwaymech:consumes	RHEA:59129	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59129		"[{""reference_id"": ""RHEA:59129"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:30616 to substrates with coefficient 1."", ""source_locator"": ""rh:59129/rh:substrates -> http://rdf.rhea-db.org/59128_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59128_compound_6372; rh:compound -> http://rdf.rhea-db.org/Compound_6372; rh:chebi""}]"	"[{""id"": ""RHEA:59129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59129 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-031_1a8012988c8a	RHEA:59129	pathwaymech:produces	CHEBI:142971	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:136993|RHEA:59129		"[{""reference_id"": ""RHEA:59129"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:142971 to products with coefficient 1."", ""source_locator"": ""rh:59129/rh:products -> http://rdf.rhea-db.org/59128_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59128_compound_15296; rh:compound -> http://rdf.rhea-db.org/Compound_15296; rh:chebi""}, {""reference_id"": ""CHEBI:136993"", ""source_assertion"": ""The selected ChEBI structure specifies the citryl center; this is a current chemical-authority convention, not a direct stereochemical assay on this Newman intermediate."", ""source_locator"": ""Semantic SQL CHEBI:142971/chemrof:inchi_string; rdfs:label""}]"	"[{""id"": ""CHEBI:136993"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; hash covers full uncompressed original database"", ""title"": ""ChEBI 255 formal chemical structures and charge states"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""RHEA:59129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59129 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-032_292faa085ced	RHEA:59129	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59129		"[{""reference_id"": ""RHEA:59129"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:456215 to products with coefficient 1."", ""source_locator"": ""rh:59129/rh:products -> http://rdf.rhea-db.org/59128_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59128_compound_2590; rh:compound -> http://rdf.rhea-db.org/Compound_2590; rh:chebi""}]"	"[{""id"": ""RHEA:59129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59129 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-033_9a8a75019a92	RHEA:59129	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59129		"[{""reference_id"": ""RHEA:59129"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:33019 to products with coefficient 1."", ""source_locator"": ""rh:59129/rh:products -> http://rdf.rhea-db.org/59128_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59128_compound_2106; rh:compound -> http://rdf.rhea-db.org/Compound_2106; rh:chebi""}]"	"[{""id"": ""RHEA:59129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59129 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-034_40cd5ec24471	CHEBI:142971	pathwaymech:consumes	RHEA:59133	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:136993|RHEA:59133		"[{""reference_id"": ""RHEA:59133"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:142971 to substrates with coefficient 1."", ""source_locator"": ""rh:59133/rh:substrates -> http://rdf.rhea-db.org/59132_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59132_compound_15296; rh:compound -> http://rdf.rhea-db.org/Compound_15296; rh:chebi""}, {""reference_id"": ""CHEBI:136993"", ""source_assertion"": ""The selected ChEBI structure specifies the citryl center; this is a current chemical-authority convention, not a direct stereochemical assay on this Newman intermediate."", ""source_locator"": ""Semantic SQL CHEBI:142971/chemrof:inchi_string; rdfs:label""}]"	"[{""id"": ""CHEBI:136993"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; hash covers full uncompressed original database"", ""title"": ""ChEBI 255 formal chemical structures and charge states"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""RHEA:59133"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59133 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-035_1512ade7ff31	CHEBI:16810	pathwaymech:consumes	RHEA:59133	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59133		"[{""reference_id"": ""RHEA:59133"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:16810 to substrates with coefficient 1."", ""source_locator"": ""rh:59133/rh:substrates -> http://rdf.rhea-db.org/59132_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59132_compound_2975; rh:compound -> http://rdf.rhea-db.org/Compound_2975; rh:chebi""}]"	"[{""id"": ""RHEA:59133"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59133 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-036_c7fcafd75a47	CHEBI:30616	pathwaymech:consumes	RHEA:59133	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59133		"[{""reference_id"": ""RHEA:59133"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:30616 to substrates with coefficient 1."", ""source_locator"": ""rh:59133/rh:substrates -> http://rdf.rhea-db.org/59132_L; rh:contains1 -> http://rdf.rhea-db.org/Participant_59132_compound_6372; rh:compound -> http://rdf.rhea-db.org/Compound_6372; rh:chebi""}]"	"[{""id"": ""RHEA:59133"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59133 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-037_40ebe673200b	RHEA:59133	pathwaymech:produces	CHEBI:136993	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	CHEBI:136993|DOI:10.1021/jacs.5b04557.s001|PubChem:122234488|RHEA:59133	Formal open-chain dianion output of the current Rhea net equation. The primary characterized cyclic hemiaminal is a distinct connectivity; no claim of a uniquely linear physiological species or exact identity is made.	"[{""reference_id"": ""RHEA:59133"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:136993 to products with coefficient 1."", ""source_locator"": ""rh:59133/rh:products -> http://rdf.rhea-db.org/59132_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59132_compound_15367; rh:compound -> http://rdf.rhea-db.org/Compound_15367; rh:chebi""}, {""reference_id"": ""CHEBI:136993"", ""source_assertion"": ""CHEBI:136993 has an open-chain alpha-ketoamide terminus and specified S-citrate center; it is not the cyclic hemiaminal neutral structure."", ""source_locator"": ""Semantic SQL CHEBI:136993/chemrof:inchi_string; chemrof:charge""}, {""reference_id"": ""DOI:10.1021/jacs.5b04557.s001"", ""source_assertion"": ""The original SB structure is cyclic; S7 describes a 1:1 epimer mixture arising from equilibrating lactamization. This limits the interpretation of the formal linear output, rather than demonstrating a linear-only physiological product."", ""source_locator"": ""S7, SB1 product-description paragraph; S38 TableS3; S39 TableS4; S42 FigureS2""}, {""reference_id"": ""PubChem:122234488"", ""source_assertion"": ""CID 122234488 independently defines a neutral cyclic hemiaminal with S amino-acid/S citrate centers and an unspecified additional center, a distinct structure from the formal linear dianion."", ""source_locator"": ""/PropertyTable/Properties[0]/InChI, InChIKey, IUPACName, Charge""}]"	"[{""id"": ""CHEBI:136993"", ""source_sha256"": ""26ad4890cdcf6ee357760d815dfee8f5ba81e0873e62cb379369b04205722b0f"", ""source_version"": ""ChEBI 255 Semantic SQL; hash covers full uncompressed original database"", ""title"": ""ChEBI 255 formal chemical structures and charge states"", ""url"": ""https://www.ebi.ac.uk/chebi/""}, {""id"": ""DOI:10.1021/jacs.5b04557.s001"", ""source_sha256"": ""40074e10e7f5be10458e9141eb4b704c0400827af4c05a98c158133e45a1f59d"", ""source_version"": ""Original publisher supplement, 69 pages; S7/S38/S39/S42 inspected; exact PDF bytes"", ""title"": ""Supporting Information for Chemical Synthesis of Staphyloferrin B Affords Insight into the Molecular Structure, Iron Chelation, and Biological Activity of a Polycarboxylate Siderophore Deployed by the Human Pathogen Staphylococcus aureus."", ""url"": ""https://ndownloader.figshare.com/files/3781477""}, {""id"": ""PubChem:122234488"", ""source_sha256"": ""9950fe79b11f9ca681b458189015cf64b77d045341057fcf2f04335dd3995ba3"", ""source_version"": ""Original PubChem property response retrieved 2026-10-11; current systematic name, not removed SB synonym; contextual identity reference only"", ""title"": ""PubChem CID 122234488: neutral cyclic hemiaminal structure with two specified and one unspecified stereocenters"", ""url"": ""https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/122234488/property/IUPACName,InChI,InChIKey,CanonicalSMILES,IsomericSMILES,MolecularFormula,Charge/JSON""}, {""id"": ""RHEA:59133"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59133 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-038_f4af569e4276	RHEA:59133	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59133		"[{""reference_id"": ""RHEA:59133"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:456215 to products with coefficient 1."", ""source_locator"": ""rh:59133/rh:products -> http://rdf.rhea-db.org/59132_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59132_compound_2590; rh:compound -> http://rdf.rhea-db.org/Compound_2590; rh:chebi""}]"	"[{""id"": ""RHEA:59133"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59133 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-039_63a6ead74d0f	RHEA:59133	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59133		"[{""reference_id"": ""RHEA:59133"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:33019 to products with coefficient 1."", ""source_locator"": ""rh:59133/rh:products -> http://rdf.rhea-db.org/59132_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59132_compound_2106; rh:compound -> http://rdf.rhea-db.org/Compound_2106; rh:chebi""}]"	"[{""id"": ""RHEA:59133"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59133 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-040_2d569015b26f	RHEA:59133	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59133		"[{""reference_id"": ""RHEA:59133"", ""source_assertion"": ""The selected Rhea direction assigns CHEBI:15378 to products with coefficient 1."", ""source_locator"": ""rh:59133/rh:products -> http://rdf.rhea-db.org/59132_R; rh:contains1 -> http://rdf.rhea-db.org/Participant_59132_compound_3249; rh:compound -> http://rdf.rhea-db.org/Compound_3249; rh:chebi""}]"	"[{""id"": ""RHEA:59133"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59133 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-041_78c9ed786558	RHEA:59113	BFO:0000050	MetaCyc:PWY-8008	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-8008|MetaCyc:RXN-19819|RHEA:59113	Native and current equations are compared by explicit chemistry; no unasserted native Rhea cross-reference is claimed.	"[{""reference_id"": ""MetaCyc:PWY-8008"", ""source_assertion"": ""PWY-8008 includes native reaction RXN-19819 within its seven-reaction biosynthetic definition."", ""source_locator"": ""Pathway[@frameid=\""PWY-8008\""]/reaction-list/Reaction[@frameid=\""RXN-19819\""]""}, {""reference_id"": ""MetaCyc:RXN-19819"", ""source_assertion"": ""The native reaction is physiologically left-to-right. Its stored molecular forms and coefficients are retained separately from the selected current Rhea equation."", ""source_locator"": ""Reaction/reaction-direction; left; right""}, {""reference_id"": ""RHEA:59113"", ""source_assertion"": ""The original Rhea master 59112 explicitly lists directed reaction 59113; its selected substrates are 59112_L and products 59112_R."", ""source_locator"": ""rh:59112/rh:directionalReaction -> rh:59113; rh:59113/rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-8008"", ""source_sha256"": ""b74a612c7a5197d8ea861622571f48c4c9a0464516733e4ddae7c6f720f88ad4"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-8008 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-8008""}, {""id"": ""MetaCyc:RXN-19819"", ""source_sha256"": ""5bd707ba8b8f4396734c7dd367a9b892d178b26c0c6056bc88c3e767fa61b898"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc RXN-19819 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19819""}, {""id"": ""RHEA:59113"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59113 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-042_277c707f6a3b	RHEA:52385	BFO:0000050	MetaCyc:PWY-8008	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-8008|MetaCyc:RXN-18395|RHEA:52385	Native and current equations are compared by explicit chemistry; no unasserted native Rhea cross-reference is claimed. Native proton bookkeeping differs; current balanced Rhea coefficients are selected.	"[{""reference_id"": ""MetaCyc:PWY-8008"", ""source_assertion"": ""PWY-8008 includes native reaction RXN-18395 within its seven-reaction biosynthetic definition."", ""source_locator"": ""Pathway[@frameid=\""PWY-8008\""]/reaction-list/Reaction[@frameid=\""RXN-18395\""]""}, {""reference_id"": ""MetaCyc:RXN-18395"", ""source_assertion"": ""The native reaction is physiologically left-to-right. Its stored molecular forms and coefficients are retained separately from the selected current Rhea equation."", ""source_locator"": ""Reaction/reaction-direction; left; right""}, {""reference_id"": ""RHEA:52385"", ""source_assertion"": ""The original Rhea master 52384 explicitly lists directed reaction 52385; its selected substrates are 52384_L and products 52384_R."", ""source_locator"": ""rh:52384/rh:directionalReaction -> rh:52385; rh:52385/rh:substrates; rh:products""}, {""reference_id"": ""MetaCyc:RXN-18395"", ""source_assertion"": ""The native RHEA dblink explicitly supplies the selected directed identifier."", ""source_locator"": ""Reaction/dblink[dblink-db=\""RHEA\""]/dblink-oid""}]"	"[{""id"": ""MetaCyc:PWY-8008"", ""source_sha256"": ""b74a612c7a5197d8ea861622571f48c4c9a0464516733e4ddae7c6f720f88ad4"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-8008 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-8008""}, {""id"": ""MetaCyc:RXN-18395"", ""source_sha256"": ""d0974e136cb620b94bff459e277a7958be65edca6b4eca882fc69a1d31077090"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc RXN-18395 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-18395""}, {""id"": ""RHEA:52385"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:52385 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-043_78f6135fd01e	RHEA:51929	BFO:0000050	MetaCyc:PWY-8008	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-8008|MetaCyc:RXN-18393|RHEA:51929	Native and current equations are compared by explicit chemistry; no unasserted native Rhea cross-reference is claimed.	"[{""reference_id"": ""MetaCyc:PWY-8008"", ""source_assertion"": ""PWY-8008 includes native reaction RXN-18393 within its seven-reaction biosynthetic definition."", ""source_locator"": ""Pathway[@frameid=\""PWY-8008\""]/reaction-list/Reaction[@frameid=\""RXN-18393\""]""}, {""reference_id"": ""MetaCyc:RXN-18393"", ""source_assertion"": ""The native reaction is physiologically left-to-right. Its stored molecular forms and coefficients are retained separately from the selected current Rhea equation."", ""source_locator"": ""Reaction/reaction-direction; left; right""}, {""reference_id"": ""RHEA:51929"", ""source_assertion"": ""The original Rhea master 51928 explicitly lists directed reaction 51929; its selected substrates are 51928_L and products 51928_R."", ""source_locator"": ""rh:51928/rh:directionalReaction -> rh:51929; rh:51929/rh:substrates; rh:products""}, {""reference_id"": ""MetaCyc:RXN-18393"", ""source_assertion"": ""The native RHEA dblink explicitly supplies the selected directed identifier."", ""source_locator"": ""Reaction/dblink[dblink-db=\""RHEA\""]/dblink-oid""}]"	"[{""id"": ""MetaCyc:PWY-8008"", ""source_sha256"": ""b74a612c7a5197d8ea861622571f48c4c9a0464516733e4ddae7c6f720f88ad4"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-8008 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-8008""}, {""id"": ""MetaCyc:RXN-18393"", ""source_sha256"": ""8abe8418b31d0edd65a6d8cab1cccf9ab88257a002ec99eb495ec06e8896a2e0"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc RXN-18393 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-18393""}, {""id"": ""RHEA:51929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:51929 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-044_b44a5248a4f4	RHEA:59125	BFO:0000050	MetaCyc:PWY-8008	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-8008|MetaCyc:RXN-19820|RHEA:59125	Native and current equations are compared by explicit chemistry; no unasserted native Rhea cross-reference is claimed. Native proton bookkeeping differs; current balanced Rhea coefficients are selected.	"[{""reference_id"": ""MetaCyc:PWY-8008"", ""source_assertion"": ""PWY-8008 includes native reaction RXN-19820 within its seven-reaction biosynthetic definition."", ""source_locator"": ""Pathway[@frameid=\""PWY-8008\""]/reaction-list/Reaction[@frameid=\""RXN-19820\""]""}, {""reference_id"": ""MetaCyc:RXN-19820"", ""source_assertion"": ""The native reaction is physiologically left-to-right. Its stored molecular forms and coefficients are retained separately from the selected current Rhea equation."", ""source_locator"": ""Reaction/reaction-direction; left; right""}, {""reference_id"": ""RHEA:59125"", ""source_assertion"": ""The original Rhea master 59124 explicitly lists directed reaction 59125; its selected substrates are 59124_L and products 59124_R."", ""source_locator"": ""rh:59124/rh:directionalReaction -> rh:59125; rh:59125/rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-8008"", ""source_sha256"": ""b74a612c7a5197d8ea861622571f48c4c9a0464516733e4ddae7c6f720f88ad4"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-8008 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-8008""}, {""id"": ""MetaCyc:RXN-19820"", ""source_sha256"": ""ac9615c05f43cf230ccc4ef4c1c5de5c221aa73cd5c60e2e2f677c1194763b22"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc RXN-19820 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19820""}, {""id"": ""RHEA:59125"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59125 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-045_6e74c20d891b	RHEA:59121	BFO:0000050	MetaCyc:PWY-8008	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-8008|MetaCyc:RXN-19821|RHEA:59121	Native and current equations are compared by explicit chemistry; no unasserted native Rhea cross-reference is claimed.	"[{""reference_id"": ""MetaCyc:PWY-8008"", ""source_assertion"": ""PWY-8008 includes native reaction RXN-19821 within its seven-reaction biosynthetic definition."", ""source_locator"": ""Pathway[@frameid=\""PWY-8008\""]/reaction-list/Reaction[@frameid=\""RXN-19821\""]""}, {""reference_id"": ""MetaCyc:RXN-19821"", ""source_assertion"": ""The native reaction is physiologically left-to-right. Its stored molecular forms and coefficients are retained separately from the selected current Rhea equation."", ""source_locator"": ""Reaction/reaction-direction; left; right""}, {""reference_id"": ""RHEA:59121"", ""source_assertion"": ""The original Rhea master 59120 explicitly lists directed reaction 59121; its selected substrates are 59120_L and products 59120_R."", ""source_locator"": ""rh:59120/rh:directionalReaction -> rh:59121; rh:59121/rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-8008"", ""source_sha256"": ""b74a612c7a5197d8ea861622571f48c4c9a0464516733e4ddae7c6f720f88ad4"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-8008 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-8008""}, {""id"": ""MetaCyc:RXN-19821"", ""source_sha256"": ""c6ca8acc37ea8c6ab16a8368c86779367ebaa0ca145f6bf2adabdeecb275e8a3"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc RXN-19821 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19821""}, {""id"": ""RHEA:59121"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59121 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-046_2b1f4e110a26	RHEA:59129	BFO:0000050	MetaCyc:PWY-8008	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-8008|MetaCyc:RXN-19822|RHEA:59129	Native and current equations are compared by explicit chemistry; no unasserted native Rhea cross-reference is claimed. Native proton bookkeeping differs; current balanced Rhea coefficients are selected.	"[{""reference_id"": ""MetaCyc:PWY-8008"", ""source_assertion"": ""PWY-8008 includes native reaction RXN-19822 within its seven-reaction biosynthetic definition."", ""source_locator"": ""Pathway[@frameid=\""PWY-8008\""]/reaction-list/Reaction[@frameid=\""RXN-19822\""]""}, {""reference_id"": ""MetaCyc:RXN-19822"", ""source_assertion"": ""The native reaction is physiologically left-to-right. Its stored molecular forms and coefficients are retained separately from the selected current Rhea equation."", ""source_locator"": ""Reaction/reaction-direction; left; right""}, {""reference_id"": ""RHEA:59129"", ""source_assertion"": ""The original Rhea master 59128 explicitly lists directed reaction 59129; its selected substrates are 59128_L and products 59128_R."", ""source_locator"": ""rh:59128/rh:directionalReaction -> rh:59129; rh:59129/rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-8008"", ""source_sha256"": ""b74a612c7a5197d8ea861622571f48c4c9a0464516733e4ddae7c6f720f88ad4"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-8008 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-8008""}, {""id"": ""MetaCyc:RXN-19822"", ""source_sha256"": ""93d43854c5d01ec83375f762c330d57a0a8598f24c5898c53a5abd7da060df43"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc RXN-19822 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19822""}, {""id"": ""RHEA:59129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59129 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-047_faf4ed4c367c	RHEA:59133	BFO:0000050	MetaCyc:PWY-8008	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-8008|MetaCyc:RXN-19823|RHEA:59133	Native and current equations are compared by explicit chemistry; no unasserted native Rhea cross-reference is claimed. The stored final product is linear; cyclic primary product characterization is retained as a molecular-form limitation.	"[{""reference_id"": ""MetaCyc:PWY-8008"", ""source_assertion"": ""PWY-8008 includes native reaction RXN-19823 within its seven-reaction biosynthetic definition."", ""source_locator"": ""Pathway[@frameid=\""PWY-8008\""]/reaction-list/Reaction[@frameid=\""RXN-19823\""]""}, {""reference_id"": ""MetaCyc:RXN-19823"", ""source_assertion"": ""The native reaction is physiologically left-to-right. Its stored molecular forms and coefficients are retained separately from the selected current Rhea equation."", ""source_locator"": ""Reaction/reaction-direction; left; right""}, {""reference_id"": ""RHEA:59133"", ""source_assertion"": ""The original Rhea master 59132 explicitly lists directed reaction 59133; its selected substrates are 59132_L and products 59132_R."", ""source_locator"": ""rh:59132/rh:directionalReaction -> rh:59133; rh:59133/rh:substrates; rh:products""}]"	"[{""id"": ""MetaCyc:PWY-8008"", ""source_sha256"": ""b74a612c7a5197d8ea861622571f48c4c9a0464516733e4ddae7c6f720f88ad4"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc PWY-8008 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-8008""}, {""id"": ""MetaCyc:RXN-19823"", ""source_sha256"": ""c23c22dca907611806b13bef22d4ed6bd42ad78e9f9b1d613428636440912ce0"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc RXN-19823 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-19823""}, {""id"": ""RHEA:59133"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59133 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-048_4509859d4126	NCBIProtein:BAF66340.1	pathwaymech:enables	RHEA:59113	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BAF66340.1|PMID:29483190|UniProtKB:Q2G1M5	Newman gene-product activity with exact native sequence bridge. This functional relation does not claim an isolated monomer is sufficient. Full engineered construct sequence is not equated to the unmodified genome translation.	"[{""reference_id"": ""PMID:29483190"", ""source_assertion"": ""Purified Newman-derived SbnI phosphorylates free L-serine to OPS. Full-length protein is predominantly dimeric; a truncated monomer remains catalytically active."", ""source_locator"": ""Results, sec4 (dimer) and sec5 (free-serine kinase); Experimental procedures, sec11 (cloning)""}, {""reference_id"": ""NCBIProtein:BAF66340.1"", ""source_assertion"": ""The original GenPept BAF66340.1 identifies locus NWMN_0068 in Newman, taxon 426430, with its native sequence."", ""source_locator"": ""GBSet/GBSeq[GBSeq_accession-version=\""BAF66340.1\""]/GBSeq_feature-table; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q2G1M5"", ""source_assertion"": ""The NCTC 8325 entry assigns RHEA:59112 and RHEA:59113 with ECO:0000269. Its original sequence is identical to the selected Newman native protein; experimental constructs remain distinct."", ""source_locator"": ""/results/0/comments/1/reaction; physiologicalReactions; /results/0/sequence/value""}]"	"[{""id"": ""NCBIProtein:BAF66340.1"", ""source_sha256"": ""239d57ac6cac356549663c1bcb819ae1c4eb614792a3bd751244e66b1368d777"", ""source_version"": ""Original seven-protein XML batch retrieved 2026-10-11; digest covers complete response, not one extracted entry"", ""title"": ""NCBI GenPept BAF66340.1 Newman protein identity"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAF66332.1,BAF66333.1,BAF66334.1,BAF66336.1,BAF66337.1,BAF66339.1,BAF66340.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:29483190"", ""source_sha256"": ""8f170e7d439f1e5316ff558e9781b948488fa9b58efc26b39667b700216526e1"", ""source_version"": ""Complete original primary article body inspected; retrieved 2026-10-11"", ""title"": ""SbnI is a free serine kinase that generates O-phospho-l-serine for staphyloferrin B biosynthesis in Staphylococcus aureus"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC5912478/""}, {""id"": ""UniProtKB:Q2G1M5"", ""source_sha256"": ""15afa127c1bc378d3cf2fc5335160aa03afb08136150d15386a22d9b6951ee6e"", ""source_version"": ""UniProt 2026_03; complete original nine-entry JSON response retrieved 2026-10-11"", ""title"": ""UniProtKB Q2G1M5 original NCTC 8325 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28accession%3AQ2G1N3%20OR%20accession%3AQ2G1N2%20OR%20accession%3AQ2G1N1%20OR%20accession%3AQ2G1N0%20OR%20accession%3AQ2G1M9%20OR%20accession%3AQ2G1M8%20OR%20accession%3AQ2G1M7%20OR%20accession%3AQ2G1M6%20OR%20accession%3AQ2G1M5%29&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-049_9218e0a20d6e	NCBIProtein:BAF66332.1	pathwaymech:enables	RHEA:52385	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.14288/1.0228113|NCBIProtein:BAF66332.1|UniProtKB:Q2G1N3	Newman gene-product activity with exact native sequence bridge. This functional relation does not claim an isolated monomer is sufficient. Full engineered construct sequence is not equated to the unmodified genome translation.	"[{""reference_id"": ""DOI:10.14288/1.0228113"", ""source_assertion"": ""Newman-derived SbnA forms ACEGA from OPS and glutamate; full-length coding-region origin and the measured precursor reaction are reported."", ""source_locator"": ""Methods2.3.2 printed37/PDF59; Results4.2.1 printed89-92/PDF111-114""}, {""reference_id"": ""NCBIProtein:BAF66332.1"", ""source_assertion"": ""The original GenPept BAF66332.1 identifies locus NWMN_0060 in Newman, taxon 426430, with its native sequence."", ""source_locator"": ""GBSet/GBSeq[GBSeq_accession-version=\""BAF66332.1\""]/GBSeq_feature-table; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q2G1N3"", ""source_assertion"": ""The NCTC 8325 entry assigns RHEA:52384 and RHEA:52385 with ECO:0000269. Its original sequence is identical to the selected Newman native protein; experimental constructs remain distinct."", ""source_locator"": ""/results/3/comments/1/reaction; physiologicalReactions; /results/3/sequence/value""}]"	"[{""id"": ""DOI:10.14288/1.0228113"", ""source_sha256"": ""1b74519761b087ee382e50d4811e6106f7fe5525ac14e9fca5f30a75fdcd0119"", ""source_version"": ""Kobylarz 2016 author thesis; DOI verified via DataCite. Digest covers exact original PDF payload at byte822 of retained library HTTP-envelope body. Chapter4 explicitly assembled from the 2014 manuscript; separately cited from journal article."", ""title"": ""Siderophore-mediated iron metabolism in Staphylococcus aureus"", ""url"": ""https://www.collectionscanada.gc.ca/obj/thesescanada/vol2/BVAU/TC-BVAU-57023.pdf""}, {""id"": ""NCBIProtein:BAF66332.1"", ""source_sha256"": ""239d57ac6cac356549663c1bcb819ae1c4eb614792a3bd751244e66b1368d777"", ""source_version"": ""Original seven-protein XML batch retrieved 2026-10-11; digest covers complete response, not one extracted entry"", ""title"": ""NCBI GenPept BAF66332.1 Newman protein identity"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAF66332.1,BAF66333.1,BAF66334.1,BAF66336.1,BAF66337.1,BAF66339.1,BAF66340.1&rettype=gb&retmode=xml""}, {""id"": ""UniProtKB:Q2G1N3"", ""source_sha256"": ""15afa127c1bc378d3cf2fc5335160aa03afb08136150d15386a22d9b6951ee6e"", ""source_version"": ""UniProt 2026_03; complete original nine-entry JSON response retrieved 2026-10-11"", ""title"": ""UniProtKB Q2G1N3 original NCTC 8325 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28accession%3AQ2G1N3%20OR%20accession%3AQ2G1N2%20OR%20accession%3AQ2G1N1%20OR%20accession%3AQ2G1N0%20OR%20accession%3AQ2G1M9%20OR%20accession%3AQ2G1M8%20OR%20accession%3AQ2G1M7%20OR%20accession%3AQ2G1M6%20OR%20accession%3AQ2G1M5%29&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-050_705fe32956eb	NCBIProtein:BAF66333.1	pathwaymech:enables	RHEA:51929	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.14288/1.0228113|NCBIProtein:BAF66333.1|UniProtKB:Q2G1N2	Newman gene-product activity with exact native sequence bridge. This functional relation does not claim an isolated monomer is sufficient. Full engineered construct sequence is not equated to the unmodified genome translation.	"[{""reference_id"": ""DOI:10.14288/1.0228113"", ""source_assertion"": ""Newman-derived SbnB converts ACEGA and NAD to DAP, 2-oxoglutarate and NADH. The reverse reaction is also demonstrated; the chosen direction is biosynthetic flux."", ""source_locator"": ""Methods2.3.3 printed38/PDF60; Results4.2.2 printed93-94/PDF115-116; Figure4-4""}, {""reference_id"": ""NCBIProtein:BAF66333.1"", ""source_assertion"": ""The original GenPept BAF66333.1 identifies locus NWMN_0061 in Newman, taxon 426430, with its native sequence."", ""source_locator"": ""GBSet/GBSeq[GBSeq_accession-version=\""BAF66333.1\""]/GBSeq_feature-table; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q2G1N2"", ""source_assertion"": ""The NCTC 8325 entry assigns RHEA:51928 and RHEA:51929 with ECO:0000269. Its original sequence is identical to the selected Newman native protein; experimental constructs remain distinct."", ""source_locator"": ""/results/1/comments/1/reaction; physiologicalReactions; /results/1/sequence/value""}, {""reference_id"": ""DOI:10.14288/1.0228113"", ""source_assertion"": ""Newman-derived SbnB is predominantly dimeric in solution; dynamic scattering and MALS support the assembly. This does not change the separate NCTC 8325 native-complex identity."", ""source_locator"": ""Results 4.2.4, printed 98/PDF 120; Figure 4-7""}]"	"[{""id"": ""DOI:10.14288/1.0228113"", ""source_sha256"": ""1b74519761b087ee382e50d4811e6106f7fe5525ac14e9fca5f30a75fdcd0119"", ""source_version"": ""Kobylarz 2016 author thesis; DOI verified via DataCite. Digest covers exact original PDF payload at byte822 of retained library HTTP-envelope body. Chapter4 explicitly assembled from the 2014 manuscript; separately cited from journal article."", ""title"": ""Siderophore-mediated iron metabolism in Staphylococcus aureus"", ""url"": ""https://www.collectionscanada.gc.ca/obj/thesescanada/vol2/BVAU/TC-BVAU-57023.pdf""}, {""id"": ""NCBIProtein:BAF66333.1"", ""source_sha256"": ""239d57ac6cac356549663c1bcb819ae1c4eb614792a3bd751244e66b1368d777"", ""source_version"": ""Original seven-protein XML batch retrieved 2026-10-11; digest covers complete response, not one extracted entry"", ""title"": ""NCBI GenPept BAF66333.1 Newman protein identity"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAF66332.1,BAF66333.1,BAF66334.1,BAF66336.1,BAF66337.1,BAF66339.1,BAF66340.1&rettype=gb&retmode=xml""}, {""id"": ""UniProtKB:Q2G1N2"", ""source_sha256"": ""15afa127c1bc378d3cf2fc5335160aa03afb08136150d15386a22d9b6951ee6e"", ""source_version"": ""UniProt 2026_03; complete original nine-entry JSON response retrieved 2026-10-11"", ""title"": ""UniProtKB Q2G1N2 original NCTC 8325 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28accession%3AQ2G1N3%20OR%20accession%3AQ2G1N2%20OR%20accession%3AQ2G1N1%20OR%20accession%3AQ2G1N0%20OR%20accession%3AQ2G1M9%20OR%20accession%3AQ2G1M8%20OR%20accession%3AQ2G1M7%20OR%20accession%3AQ2G1M6%20OR%20accession%3AQ2G1M5%29&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-051_543e2c86abb3	NCBIProtein:BAF66336.1	pathwaymech:enables	RHEA:59125	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BAF66336.1|PMID:19775248|UniProtKB:Q2G1M9	Newman gene-product activity with exact native sequence bridge. This functional relation does not claim an isolated monomer is sufficient. Full engineered construct sequence is not equated to the unmodified genome translation.	"[{""reference_id"": ""PMID:19775248"", ""source_assertion"": ""Purified SbnE ligates citrate to DAP, supported by substrate assays and isotope-shifted product masses. Newman coding regions were used; the reported free intermediates do not establish every selected ionic or stereochemical form."", ""source_locator"": ""Results, SbnE citrate-desymmetrizing enzyme section; Figure7A; Experimental procedures, Protein overexpression and purification""}, {""reference_id"": ""NCBIProtein:BAF66336.1"", ""source_assertion"": ""The original GenPept BAF66336.1 identifies locus NWMN_0064 in Newman, taxon 426430, with its native sequence."", ""source_locator"": ""GBSet/GBSeq[GBSeq_accession-version=\""BAF66336.1\""]/GBSeq_feature-table; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q2G1M9"", ""source_assertion"": ""The NCTC 8325 entry assigns RHEA:59124 and RHEA:59125 with ECO:0000269. Its original sequence is identical to the selected Newman native protein; experimental constructs remain distinct."", ""source_locator"": ""/results/4/comments/1/reaction; physiologicalReactions; /results/4/sequence/value""}]"	"[{""id"": ""NCBIProtein:BAF66336.1"", ""source_sha256"": ""239d57ac6cac356549663c1bcb819ae1c4eb614792a3bd751244e66b1368d777"", ""source_version"": ""Original seven-protein XML batch retrieved 2026-10-11; digest covers complete response, not one extracted entry"", ""title"": ""NCBI GenPept BAF66336.1 Newman protein identity"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAF66332.1,BAF66333.1,BAF66334.1,BAF66336.1,BAF66337.1,BAF66339.1,BAF66340.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:19775248"", ""source_version"": ""Complete original publisher text inspected through web access on 2026-10-11; no locally retained full-body digest; indexed metadata separately retained"", ""title"": ""Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus."", ""url"": ""https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2009.06880.x""}, {""id"": ""UniProtKB:Q2G1M9"", ""source_sha256"": ""15afa127c1bc378d3cf2fc5335160aa03afb08136150d15386a22d9b6951ee6e"", ""source_version"": ""UniProt 2026_03; complete original nine-entry JSON response retrieved 2026-10-11"", ""title"": ""UniProtKB Q2G1M9 original NCTC 8325 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28accession%3AQ2G1N3%20OR%20accession%3AQ2G1N2%20OR%20accession%3AQ2G1N1%20OR%20accession%3AQ2G1N0%20OR%20accession%3AQ2G1M9%20OR%20accession%3AQ2G1M8%20OR%20accession%3AQ2G1M7%20OR%20accession%3AQ2G1M6%20OR%20accession%3AQ2G1M5%29&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-052_f38ab329116e	NCBIProtein:BAF66339.1	pathwaymech:enables	RHEA:59121	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BAF66339.1|PMID:19775248|UniProtKB:Q2G1M6	Newman gene-product activity with exact native sequence bridge. This functional relation does not claim an isolated monomer is sufficient. Full engineered construct sequence is not equated to the unmodified genome translation.	"[{""reference_id"": ""PMID:19775248"", ""source_assertion"": ""Addition of SbnH converts the citryl-DAP intermediate to a decarboxylated intermediate. The enzyme is reported as a PLP-dependent dimer, while no unique monomer sufficiency is established."", ""source_locator"": ""Results, SbnH carries out PLP-dependent decarboxylation; Figure7B; Experimental procedures, Protein overexpression and purification""}, {""reference_id"": ""NCBIProtein:BAF66339.1"", ""source_assertion"": ""The original GenPept BAF66339.1 identifies locus NWMN_0067 in Newman, taxon 426430, with its native sequence."", ""source_locator"": ""GBSet/GBSeq[GBSeq_accession-version=\""BAF66339.1\""]/GBSeq_feature-table; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q2G1M6"", ""source_assertion"": ""The NCTC 8325 entry assigns RHEA:59120 and RHEA:59121 with ECO:0000269. Its original sequence is identical to the selected Newman native protein; experimental constructs remain distinct."", ""source_locator"": ""/results/2/comments/1/reaction; physiologicalReactions; /results/2/sequence/value""}]"	"[{""id"": ""NCBIProtein:BAF66339.1"", ""source_sha256"": ""239d57ac6cac356549663c1bcb819ae1c4eb614792a3bd751244e66b1368d777"", ""source_version"": ""Original seven-protein XML batch retrieved 2026-10-11; digest covers complete response, not one extracted entry"", ""title"": ""NCBI GenPept BAF66339.1 Newman protein identity"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAF66332.1,BAF66333.1,BAF66334.1,BAF66336.1,BAF66337.1,BAF66339.1,BAF66340.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:19775248"", ""source_version"": ""Complete original publisher text inspected through web access on 2026-10-11; no locally retained full-body digest; indexed metadata separately retained"", ""title"": ""Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus."", ""url"": ""https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2009.06880.x""}, {""id"": ""UniProtKB:Q2G1M6"", ""source_sha256"": ""15afa127c1bc378d3cf2fc5335160aa03afb08136150d15386a22d9b6951ee6e"", ""source_version"": ""UniProt 2026_03; complete original nine-entry JSON response retrieved 2026-10-11"", ""title"": ""UniProtKB Q2G1M6 original NCTC 8325 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28accession%3AQ2G1N3%20OR%20accession%3AQ2G1N2%20OR%20accession%3AQ2G1N1%20OR%20accession%3AQ2G1N0%20OR%20accession%3AQ2G1M9%20OR%20accession%3AQ2G1M8%20OR%20accession%3AQ2G1M7%20OR%20accession%3AQ2G1M6%20OR%20accession%3AQ2G1M5%29&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-053_adfd805eec76	NCBIProtein:BAF66337.1	pathwaymech:enables	RHEA:59129	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BAF66337.1|PMID:19775248|UniProtKB:Q2G1M8	Newman gene-product activity with exact native sequence bridge. This functional relation does not claim an isolated monomer is sufficient. Full engineered construct sequence is not equated to the unmodified genome translation.	"[{""reference_id"": ""PMID:19775248"", ""source_assertion"": ""SbnF adds the second DAP unit to citryl-diaminoethane in the proposed assembly sequence, supported by the intermediate mass and substrate assays. Solution monomer/dimer mixtures are reported."", ""source_locator"": ""Results, SbnF is necessary to form a staphyloferrin B intermediate; Figure7C; Experimental procedures, Protein overexpression and purification""}, {""reference_id"": ""NCBIProtein:BAF66337.1"", ""source_assertion"": ""The original GenPept BAF66337.1 identifies locus NWMN_0065 in Newman, taxon 426430, with its native sequence."", ""source_locator"": ""GBSet/GBSeq[GBSeq_accession-version=\""BAF66337.1\""]/GBSeq_feature-table; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q2G1M8"", ""source_assertion"": ""The NCTC 8325 entry assigns RHEA:59128 and RHEA:59129 with ECO:0000269. Its original sequence is identical to the selected Newman native protein; experimental constructs remain distinct."", ""source_locator"": ""/results/6/comments/1/reaction; physiologicalReactions; /results/6/sequence/value""}]"	"[{""id"": ""NCBIProtein:BAF66337.1"", ""source_sha256"": ""239d57ac6cac356549663c1bcb819ae1c4eb614792a3bd751244e66b1368d777"", ""source_version"": ""Original seven-protein XML batch retrieved 2026-10-11; digest covers complete response, not one extracted entry"", ""title"": ""NCBI GenPept BAF66337.1 Newman protein identity"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAF66332.1,BAF66333.1,BAF66334.1,BAF66336.1,BAF66337.1,BAF66339.1,BAF66340.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:19775248"", ""source_version"": ""Complete original publisher text inspected through web access on 2026-10-11; no locally retained full-body digest; indexed metadata separately retained"", ""title"": ""Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus."", ""url"": ""https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2009.06880.x""}, {""id"": ""UniProtKB:Q2G1M8"", ""source_sha256"": ""15afa127c1bc378d3cf2fc5335160aa03afb08136150d15386a22d9b6951ee6e"", ""source_version"": ""UniProt 2026_03; complete original nine-entry JSON response retrieved 2026-10-11"", ""title"": ""UniProtKB Q2G1M8 original NCTC 8325 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28accession%3AQ2G1N3%20OR%20accession%3AQ2G1N2%20OR%20accession%3AQ2G1N1%20OR%20accession%3AQ2G1N0%20OR%20accession%3AQ2G1M9%20OR%20accession%3AQ2G1M8%20OR%20accession%3AQ2G1M7%20OR%20accession%3AQ2G1M6%20OR%20accession%3AQ2G1M5%29&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-054_dc828e3dc00f	NCBIProtein:BAF66334.1	pathwaymech:enables	RHEA:59133	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:BAF66334.1|PMID:19775248|UniProtKB:Q2G1N1	Newman gene-product activity with exact native sequence bridge. This functional relation does not claim an isolated monomer is sufficient. Full engineered construct sequence is not equated to the unmodified genome translation.	"[{""reference_id"": ""PMID:19775248"", ""source_assertion"": ""SbnC is required for the final 2-oxoglutarate ligation and biologically active SB assembly. The measured mass does not distinguish the later characterized cyclic hemiaminal from the formal linear reaction convention."", ""source_locator"": ""Results, SbnC activates α-KG in a reaction that completes the synthesis of staphyloferrin B; Figure7D; Experimental procedures, Protein overexpression and purification""}, {""reference_id"": ""NCBIProtein:BAF66334.1"", ""source_assertion"": ""The original GenPept BAF66334.1 identifies locus NWMN_0062 in Newman, taxon 426430, with its native sequence."", ""source_locator"": ""GBSet/GBSeq[GBSeq_accession-version=\""BAF66334.1\""]/GBSeq_feature-table; GBSeq_sequence""}, {""reference_id"": ""UniProtKB:Q2G1N1"", ""source_assertion"": ""The NCTC 8325 entry assigns RHEA:59132 and RHEA:59133 with ECO:0000269. Its original sequence is identical to the selected Newman native protein; experimental constructs remain distinct."", ""source_locator"": ""/results/7/comments/1/reaction; physiologicalReactions; /results/7/sequence/value""}]"	"[{""id"": ""NCBIProtein:BAF66334.1"", ""source_sha256"": ""239d57ac6cac356549663c1bcb819ae1c4eb614792a3bd751244e66b1368d777"", ""source_version"": ""Original seven-protein XML batch retrieved 2026-10-11; digest covers complete response, not one extracted entry"", ""title"": ""NCBI GenPept BAF66334.1 Newman protein identity"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=BAF66332.1,BAF66333.1,BAF66334.1,BAF66336.1,BAF66337.1,BAF66339.1,BAF66340.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:19775248"", ""source_version"": ""Complete original publisher text inspected through web access on 2026-10-11; no locally retained full-body digest; indexed metadata separately retained"", ""title"": ""Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus."", ""url"": ""https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2009.06880.x""}, {""id"": ""UniProtKB:Q2G1N1"", ""source_sha256"": ""15afa127c1bc378d3cf2fc5335160aa03afb08136150d15386a22d9b6951ee6e"", ""source_version"": ""UniProt 2026_03; complete original nine-entry JSON response retrieved 2026-10-11"", ""title"": ""UniProtKB Q2G1N1 original NCTC 8325 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28accession%3AQ2G1N3%20OR%20accession%3AQ2G1N2%20OR%20accession%3AQ2G1N1%20OR%20accession%3AQ2G1N0%20OR%20accession%3AQ2G1M9%20OR%20accession%3AQ2G1M8%20OR%20accession%3AQ2G1M7%20OR%20accession%3AQ2G1M6%20OR%20accession%3AQ2G1M5%29&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-055_565803cebe03	UniProtKB:Q2G1M5	BFO:0000050	MetaCyc:CPLX-9312	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-9312|MetaCyc:G1I0R-77-MONOMER	The named component and complex retain NCTC 8325 source identity; they are not renamed Newman entities.	"[{""reference_id"": ""MetaCyc:CPLX-9312"", ""source_assertion"": ""The native NCTC 8325 complex contains two copies of G1I0R-77-MONOMER; this is the source-defined assembly projection."", ""source_locator"": ""Protein/component/Protein; component/coefficient; species/Organism""}, {""reference_id"": ""MetaCyc:G1I0R-77-MONOMER"", ""source_assertion"": ""The native component explicitly cross-references UniProt Q2G1M5."", ""source_locator"": ""Protein/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}]"	"[{""id"": ""MetaCyc:CPLX-9312"", ""source_sha256"": ""91ea8fc14116f519b85508fe93268f255c1b8d631755d3d839dda7c92db60d2e"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc CPLX-9312 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-9312""}, {""id"": ""MetaCyc:G1I0R-77-MONOMER"", ""source_sha256"": ""2cfa4861e970a3e73179b5c5a6bf20ca799380dffc72e611286cb67352d0764e"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc G1I0R-77-MONOMER native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G1I0R-77-MONOMER""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-056_d922a960e24e	MetaCyc:CPLX-9312	pathwaymech:catalyzes	RHEA:59113	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-9312|UniProtKB:Q2G1M5	Curated NCTC 8325 assembly/activity assertion. SbnI oligomerization is not essential for kinase activity; SbnB solution dimer evidence is independently reported for Newman-derived protein.	"[{""reference_id"": ""MetaCyc:CPLX-9312"", ""source_assertion"": ""The native complex has an enzymatic-reaction link to the represented native transformation; the Rhea reaction is selected via the separately documented chemistry bridge."", ""source_locator"": ""Protein/catalyzes/Enzymatic-Reaction/reaction/Reaction""}, {""reference_id"": ""UniProtKB:Q2G1M5"", ""source_assertion"": ""The component entry assigns the selected reaction and a homooligomeric assembly. Primary Newman experiments and exact sequence equality support comparison, not a change of source strain."", ""source_locator"": ""/results/0/comments (CATALYTIC ACTIVITY; SUBUNIT); /results/0/sequence/value""}]"	"[{""id"": ""MetaCyc:CPLX-9312"", ""source_sha256"": ""91ea8fc14116f519b85508fe93268f255c1b8d631755d3d839dda7c92db60d2e"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc CPLX-9312 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-9312""}, {""id"": ""UniProtKB:Q2G1M5"", ""source_sha256"": ""15afa127c1bc378d3cf2fc5335160aa03afb08136150d15386a22d9b6951ee6e"", ""source_version"": ""UniProt 2026_03; complete original nine-entry JSON response retrieved 2026-10-11"", ""title"": ""UniProtKB Q2G1M5 original NCTC 8325 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28accession%3AQ2G1N3%20OR%20accession%3AQ2G1N2%20OR%20accession%3AQ2G1N1%20OR%20accession%3AQ2G1N0%20OR%20accession%3AQ2G1M9%20OR%20accession%3AQ2G1M8%20OR%20accession%3AQ2G1M7%20OR%20accession%3AQ2G1M6%20OR%20accession%3AQ2G1M5%29&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-057_333758b750a8	UniProtKB:Q2G1N2	BFO:0000050	MetaCyc:CPLX-9313	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-9313|MetaCyc:G1I0R-70-MONOMER	The named component and complex retain NCTC 8325 source identity; they are not renamed Newman entities.	"[{""reference_id"": ""MetaCyc:CPLX-9313"", ""source_assertion"": ""The native NCTC 8325 complex contains two copies of G1I0R-70-MONOMER; this is the source-defined assembly projection."", ""source_locator"": ""Protein/component/Protein; component/coefficient; species/Organism""}, {""reference_id"": ""MetaCyc:G1I0R-70-MONOMER"", ""source_assertion"": ""The native component explicitly cross-references UniProt Q2G1N2."", ""source_locator"": ""Protein/dblink[dblink-db=\""UNIPROT\""]/dblink-oid""}]"	"[{""id"": ""MetaCyc:CPLX-9313"", ""source_sha256"": ""071fba53937b0f2ba8728b01ec11d06eb6e3316ef71f8bf1e1cd9ddbb6ee688f"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc CPLX-9313 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-9313""}, {""id"": ""MetaCyc:G1I0R-70-MONOMER"", ""source_sha256"": ""a69ea7d44f045e1f256aad07db04bc2a0ce1a1f0d35cd5cd8f5d0d8613fab32e"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc G1I0R-70-MONOMER native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G1I0R-70-MONOMER""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-058_b8a1e978e32d	MetaCyc:CPLX-9313	pathwaymech:catalyzes	RHEA:51929	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX-9313|UniProtKB:Q2G1N2	Curated NCTC 8325 assembly/activity assertion. SbnI oligomerization is not essential for kinase activity; SbnB solution dimer evidence is independently reported for Newman-derived protein.	"[{""reference_id"": ""MetaCyc:CPLX-9313"", ""source_assertion"": ""The native complex has an enzymatic-reaction link to the represented native transformation; the Rhea reaction is selected via the separately documented chemistry bridge."", ""source_locator"": ""Protein/catalyzes/Enzymatic-Reaction/reaction/Reaction""}, {""reference_id"": ""UniProtKB:Q2G1N2"", ""source_assertion"": ""The component entry assigns the selected reaction and a homooligomeric assembly. Primary Newman experiments and exact sequence equality support comparison, not a change of source strain."", ""source_locator"": ""/results/1/comments (CATALYTIC ACTIVITY; SUBUNIT); /results/1/sequence/value""}]"	"[{""id"": ""MetaCyc:CPLX-9313"", ""source_sha256"": ""071fba53937b0f2ba8728b01ec11d06eb6e3316ef71f8bf1e1cd9ddbb6ee688f"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc CPLX-9313 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX-9313""}, {""id"": ""UniProtKB:Q2G1N2"", ""source_sha256"": ""15afa127c1bc378d3cf2fc5335160aa03afb08136150d15386a22d9b6951ee6e"", ""source_version"": ""UniProt 2026_03; complete original nine-entry JSON response retrieved 2026-10-11"", ""title"": ""UniProtKB Q2G1N2 original NCTC 8325 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28accession%3AQ2G1N3%20OR%20accession%3AQ2G1N2%20OR%20accession%3AQ2G1N1%20OR%20accession%3AQ2G1N0%20OR%20accession%3AQ2G1M9%20OR%20accession%3AQ2G1M8%20OR%20accession%3AQ2G1M7%20OR%20accession%3AQ2G1M6%20OR%20accession%3AQ2G1M5%29&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-059_a034ab15922d	NCBIProtein:BAF66332.1	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:26794841|UniProtKB:Q2G1N3		"[{""reference_id"": ""PMID:26794841"", ""source_assertion"": ""Purified Newman-derived SbnA is a dimer with bound PLP; crystallographic PLP binding is reported. The selected ChEBI charge state is the current chemical convention."", ""source_locator"": ""sec2.1 paragraph1; sec3.1 paragraphs1-2; Figure1""}, {""reference_id"": ""UniProtKB:Q2G1N3"", ""source_assertion"": ""The sequence-identical NCTC 8325 entry explicitly assigns pyridoxal phosphate CHEBI:597326 with ECO:0000269."", ""source_locator"": ""/results/3/comments/2/cofactors/0""}]"	"[{""id"": ""PMID:26794841"", ""source_sha256"": ""36378b379c802dcfe0951c3f3e08e3b9945b507a97808c3281903cdbffc4cdfc"", ""source_version"": ""Complete original primary article body inspected; retrieved 2026-10-11"", ""title"": ""Deciphering the Substrate Specificity of SbnA, the\nEnzyme Catalyzing the First\nStep in Staphyloferrin B Biosynthesis"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5084695/fullTextXML""}, {""id"": ""UniProtKB:Q2G1N3"", ""source_sha256"": ""15afa127c1bc378d3cf2fc5335160aa03afb08136150d15386a22d9b6951ee6e"", ""source_version"": ""UniProt 2026_03; complete original nine-entry JSON response retrieved 2026-10-11"", ""title"": ""UniProtKB Q2G1N3 original NCTC 8325 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28accession%3AQ2G1N3%20OR%20accession%3AQ2G1N2%20OR%20accession%3AQ2G1N1%20OR%20accession%3AQ2G1N0%20OR%20accession%3AQ2G1M9%20OR%20accession%3AQ2G1M8%20OR%20accession%3AQ2G1M7%20OR%20accession%3AQ2G1M6%20OR%20accession%3AQ2G1M5%29&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-060_66c1f5a91a5f	NCBIProtein:BAF66339.1	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19775248|UniProtKB:Q2G1M6		"[{""reference_id"": ""PMID:19775248"", ""source_assertion"": ""SbnH is described as a PLP-dependent decarboxylase and its purified yellow protein is consistent with bound PLP; the selected charge state is a chemical convention."", ""source_locator"": ""Results, SbnH carries out PLP-dependent decarboxylation, opening paragraph""}, {""reference_id"": ""UniProtKB:Q2G1M6"", ""source_assertion"": ""The sequence-identical NCTC 8325 entry explicitly assigns pyridoxal phosphate CHEBI:597326 with ECO:0000269."", ""source_locator"": ""/results/2/comments/2/cofactors/0""}]"	"[{""id"": ""PMID:19775248"", ""source_version"": ""Complete original publisher text inspected through web access on 2026-10-11; no locally retained full-body digest; indexed metadata separately retained"", ""title"": ""Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus."", ""url"": ""https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2009.06880.x""}, {""id"": ""UniProtKB:Q2G1M6"", ""source_sha256"": ""15afa127c1bc378d3cf2fc5335160aa03afb08136150d15386a22d9b6951ee6e"", ""source_version"": ""UniProt 2026_03; complete original nine-entry JSON response retrieved 2026-10-11"", ""title"": ""UniProtKB Q2G1M6 original NCTC 8325 entry"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28accession%3AQ2G1N3%20OR%20accession%3AQ2G1N2%20OR%20accession%3AQ2G1N1%20OR%20accession%3AQ2G1N0%20OR%20accession%3AQ2G1M9%20OR%20accession%3AQ2G1M8%20OR%20accession%3AQ2G1M7%20OR%20accession%3AQ2G1M6%20OR%20accession%3AQ2G1M5%29&format=json&size=100""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-061_46930ca531b8	MetaCyc:CPLX-9312	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-26580	Qualified native cofactor annotation. Newman ligase roles use exact sequence correspondence to the native NCTC 8325 gene product; the complete-system Mg omission experiment does not establish individual binding counts.	"[{""reference_id"": ""MetaCyc:ENZRXN-26580"", ""source_assertion"": ""The native enzyme-activity annotation explicitly lists MG+2 as cofactor. This source-specific assignment does not establish a unique physiological metal or measured binding stoichiometry."", ""source_locator"": ""Enzymatic-Reaction/enzyme/Protein; reaction/Reaction; cofactor/Compound[@frameid=\""MG+2\""]""}]"	"[{""id"": ""MetaCyc:ENZRXN-26580"", ""source_sha256"": ""d0b862dbc6436ff87b429a15c8c9a9c33317f831377b6dc5a491cbdafc2e963d"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc ENZRXN-26580 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-26580""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-062_8c5c20f348f8	NCBIProtein:BAF66336.1	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-26574|PMID:19775248	Qualified native cofactor annotation. Newman ligase roles use exact sequence correspondence to the native NCTC 8325 gene product; the complete-system Mg omission experiment does not establish individual binding counts.	"[{""reference_id"": ""MetaCyc:ENZRXN-26574"", ""source_assertion"": ""The native enzyme-activity annotation explicitly lists MG+2 as cofactor. This source-specific assignment does not establish a unique physiological metal or measured binding stoichiometry."", ""source_locator"": ""Enzymatic-Reaction/enzyme/Protein; reaction/Reaction; cofactor/Compound[@frameid=\""MG+2\""]""}, {""reference_id"": ""PMID:19775248"", ""source_assertion"": ""Omitting Mg2+ from the complete SbnCEFH assembly prevented the SB ion; this tests the reaction system, not separate metal-binding stoichiometry for each ligase."", ""source_locator"": ""Results, In vitro synthesis of staphyloferrin B requires three NIS synthetases and a decarboxylase, Mg omission statement; Figure3""}]"	"[{""id"": ""MetaCyc:ENZRXN-26574"", ""source_sha256"": ""f4b4dda82816a565d41bdfe8e5dbc7c6d9e5f5fa8221159de113457a1fe4a080"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc ENZRXN-26574 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-26574""}, {""id"": ""PMID:19775248"", ""source_version"": ""Complete original publisher text inspected through web access on 2026-10-11; no locally retained full-body digest; indexed metadata separately retained"", ""title"": ""Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus."", ""url"": ""https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2009.06880.x""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-063_c8bc8bbcb47f	NCBIProtein:BAF66337.1	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-26576|PMID:19775248	Qualified native cofactor annotation. Newman ligase roles use exact sequence correspondence to the native NCTC 8325 gene product; the complete-system Mg omission experiment does not establish individual binding counts.	"[{""reference_id"": ""MetaCyc:ENZRXN-26576"", ""source_assertion"": ""The native enzyme-activity annotation explicitly lists MG+2 as cofactor. This source-specific assignment does not establish a unique physiological metal or measured binding stoichiometry."", ""source_locator"": ""Enzymatic-Reaction/enzyme/Protein; reaction/Reaction; cofactor/Compound[@frameid=\""MG+2\""]""}, {""reference_id"": ""PMID:19775248"", ""source_assertion"": ""Omitting Mg2+ from the complete SbnCEFH assembly prevented the SB ion; this tests the reaction system, not separate metal-binding stoichiometry for each ligase."", ""source_locator"": ""Results, In vitro synthesis of staphyloferrin B requires three NIS synthetases and a decarboxylase, Mg omission statement; Figure3""}]"	"[{""id"": ""MetaCyc:ENZRXN-26576"", ""source_sha256"": ""b7bc662cb62d9c187f5527d7f1c164232ba94dad0a7c269b1e195ef32d14bc08"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc ENZRXN-26576 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-26576""}, {""id"": ""PMID:19775248"", ""source_version"": ""Complete original publisher text inspected through web access on 2026-10-11; no locally retained full-body digest; indexed metadata separately retained"", ""title"": ""Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus."", ""url"": ""https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2009.06880.x""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-064_8a0ca9e1760d	NCBIProtein:BAF66334.1	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ENZRXN-26577|PMID:19775248	Qualified native cofactor annotation. Newman ligase roles use exact sequence correspondence to the native NCTC 8325 gene product; the complete-system Mg omission experiment does not establish individual binding counts.	"[{""reference_id"": ""MetaCyc:ENZRXN-26577"", ""source_assertion"": ""The native enzyme-activity annotation explicitly lists MG+2 as cofactor. This source-specific assignment does not establish a unique physiological metal or measured binding stoichiometry."", ""source_locator"": ""Enzymatic-Reaction/enzyme/Protein; reaction/Reaction; cofactor/Compound[@frameid=\""MG+2\""]""}, {""reference_id"": ""PMID:19775248"", ""source_assertion"": ""Omitting Mg2+ from the complete SbnCEFH assembly prevented the SB ion; this tests the reaction system, not separate metal-binding stoichiometry for each ligase."", ""source_locator"": ""Results, In vitro synthesis of staphyloferrin B requires three NIS synthetases and a decarboxylase, Mg omission statement; Figure3""}]"	"[{""id"": ""MetaCyc:ENZRXN-26577"", ""source_sha256"": ""83d62e0ff0321e6d64f2c7f3b51092944a87c7ddd1af52da296f7f82021b8bcf"", ""source_version"": ""MetaCyc 22.5; original full XML response retrieved 2026-10-11"", ""title"": ""MetaCyc ENZRXN-26577 native XML object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ENZRXN-26577""}, {""id"": ""PMID:19775248"", ""source_version"": ""Complete original publisher text inspected through web access on 2026-10-11; no locally retained full-body digest; indexed metadata separately retained"", ""title"": ""Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus."", ""url"": ""https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.2009.06880.x""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-065_d10317cecb41	RHEA:59113	RO:0002413	RHEA:52385	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:52385|RHEA:59113	Material availability in the selected network, not direct enzyme channeling or a measured flux ratio.	"[{""reference_id"": ""RHEA:59113"", ""source_assertion"": ""CHEBI:57524 is an explicit product of the selected upstream direction."", ""source_locator"": ""http://rdf.rhea-db.org/59112_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_59112_compound_1236; rh:compound -> http://rdf.rhea-db.org/Compound_1236; rh:chebi""}, {""reference_id"": ""RHEA:52385"", ""source_assertion"": ""CHEBI:57524 is an explicit substrate of the selected downstream direction."", ""source_locator"": ""http://rdf.rhea-db.org/52384_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_52384_compound_1236; rh:compound -> http://rdf.rhea-db.org/Compound_1236; rh:chebi""}]"	"[{""id"": ""RHEA:52385"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:52385 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:59113"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59113 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-066_91ec28ab65e1	RHEA:52385	RO:0002413	RHEA:51929	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51929|RHEA:52385	Material availability in the selected network, not direct enzyme channeling or a measured flux ratio.	"[{""reference_id"": ""RHEA:52385"", ""source_assertion"": ""CHEBI:134610 is an explicit product of the selected upstream direction."", ""source_locator"": ""http://rdf.rhea-db.org/52384_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_52384_compound_13099; rh:compound -> http://rdf.rhea-db.org/Compound_13099; rh:chebi""}, {""reference_id"": ""RHEA:51929"", ""source_assertion"": ""CHEBI:134610 is an explicit substrate of the selected downstream direction."", ""source_locator"": ""http://rdf.rhea-db.org/51928_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_51928_compound_13099; rh:compound -> http://rdf.rhea-db.org/Compound_13099; rh:chebi""}]"	"[{""id"": ""RHEA:51929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:51929 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:52385"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:52385 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-067_c81dae5c81dc	RHEA:51929	RO:0002413	RHEA:59125	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51929|RHEA:59125	Material availability in the selected network, not direct enzyme channeling or a measured flux ratio.	"[{""reference_id"": ""RHEA:51929"", ""source_assertion"": ""CHEBI:57721 is an explicit product of the selected upstream direction."", ""source_locator"": ""http://rdf.rhea-db.org/51928_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_51928_compound_1905; rh:compound -> http://rdf.rhea-db.org/Compound_1905; rh:chebi""}, {""reference_id"": ""RHEA:59125"", ""source_assertion"": ""CHEBI:57721 is an explicit substrate of the selected downstream direction."", ""source_locator"": ""http://rdf.rhea-db.org/59124_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_59124_compound_1905; rh:compound -> http://rdf.rhea-db.org/Compound_1905; rh:chebi""}]"	"[{""id"": ""RHEA:51929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:51929 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:59125"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59125 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-068_97f575f060fb	RHEA:59125	RO:0002413	RHEA:59121	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59121|RHEA:59125	Material availability in the selected network, not direct enzyme channeling or a measured flux ratio.	"[{""reference_id"": ""RHEA:59125"", ""source_assertion"": ""CHEBI:142969 is an explicit product of the selected upstream direction."", ""source_locator"": ""http://rdf.rhea-db.org/59124_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_59124_compound_15297; rh:compound -> http://rdf.rhea-db.org/Compound_15297; rh:chebi""}, {""reference_id"": ""RHEA:59121"", ""source_assertion"": ""CHEBI:142969 is an explicit substrate of the selected downstream direction."", ""source_locator"": ""http://rdf.rhea-db.org/59120_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_59120_compound_15297; rh:compound -> http://rdf.rhea-db.org/Compound_15297; rh:chebi""}]"	"[{""id"": ""RHEA:59121"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59121 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:59125"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59125 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-069_391ccbe10986	RHEA:59121	RO:0002413	RHEA:59129	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59121|RHEA:59129	Material availability in the selected network, not direct enzyme channeling or a measured flux ratio.	"[{""reference_id"": ""RHEA:59121"", ""source_assertion"": ""CHEBI:142970 is an explicit product of the selected upstream direction."", ""source_locator"": ""http://rdf.rhea-db.org/59120_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_59120_compound_15295; rh:compound -> http://rdf.rhea-db.org/Compound_15295; rh:chebi""}, {""reference_id"": ""RHEA:59129"", ""source_assertion"": ""CHEBI:142970 is an explicit substrate of the selected downstream direction."", ""source_locator"": ""http://rdf.rhea-db.org/59128_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_59128_compound_15295; rh:compound -> http://rdf.rhea-db.org/Compound_15295; rh:chebi""}]"	"[{""id"": ""RHEA:59121"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59121 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:59129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59129 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-070_7dc26ea6194a	RHEA:51929	RO:0002413	RHEA:59129	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51929|RHEA:59129	Material availability in the selected network, not direct enzyme channeling or a measured flux ratio.	"[{""reference_id"": ""RHEA:51929"", ""source_assertion"": ""CHEBI:57721 is an explicit product of the selected upstream direction."", ""source_locator"": ""http://rdf.rhea-db.org/51928_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_51928_compound_1905; rh:compound -> http://rdf.rhea-db.org/Compound_1905; rh:chebi""}, {""reference_id"": ""RHEA:59129"", ""source_assertion"": ""CHEBI:57721 is an explicit substrate of the selected downstream direction."", ""source_locator"": ""http://rdf.rhea-db.org/59128_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_59128_compound_1905; rh:compound -> http://rdf.rhea-db.org/Compound_1905; rh:chebi""}]"	"[{""id"": ""RHEA:51929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:51929 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:59129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59129 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-071_b760157f9e6c	RHEA:59129	RO:0002413	RHEA:59133	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:59129|RHEA:59133	Material availability in the selected network, not direct enzyme channeling or a measured flux ratio.	"[{""reference_id"": ""RHEA:59129"", ""source_assertion"": ""CHEBI:142971 is an explicit product of the selected upstream direction."", ""source_locator"": ""http://rdf.rhea-db.org/59128_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_59128_compound_15296; rh:compound -> http://rdf.rhea-db.org/Compound_15296; rh:chebi""}, {""reference_id"": ""RHEA:59133"", ""source_assertion"": ""CHEBI:142971 is an explicit substrate of the selected downstream direction."", ""source_locator"": ""http://rdf.rhea-db.org/59132_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_59132_compound_15296; rh:compound -> http://rdf.rhea-db.org/Compound_15296; rh:chebi""}]"	"[{""id"": ""RHEA:59129"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59129 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:59133"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59133 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-8008_sbn-edge-072_fbec90bd4f0a	RHEA:51929	RO:0002413	RHEA:59133	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:51929|RHEA:59133	Material availability in the selected network, not direct enzyme channeling or a measured flux ratio.	"[{""reference_id"": ""RHEA:51929"", ""source_assertion"": ""CHEBI:16810 is an explicit product of the selected upstream direction."", ""source_locator"": ""http://rdf.rhea-db.org/51928_R/rh:contains1 -> http://rdf.rhea-db.org/Participant_51928_compound_2975; rh:compound -> http://rdf.rhea-db.org/Compound_2975; rh:chebi""}, {""reference_id"": ""RHEA:59133"", ""source_assertion"": ""CHEBI:16810 is an explicit substrate of the selected downstream direction."", ""source_locator"": ""http://rdf.rhea-db.org/59132_L/rh:contains1 -> http://rdf.rhea-db.org/Participant_59132_compound_2975; rh:compound -> http://rdf.rhea-db.org/Compound_2975; rh:chebi""}]"	"[{""id"": ""RHEA:51929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:51929 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:59133"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; hash covers entire original gzip RDF"", ""title"": ""RHEA:59133 original directional reaction and side graph"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-001_c19fa89d7201	CHEBI:57292	pathwaymech:consumes	RHEA:22890	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22890		"[{""reference_id"": ""RHEA:22890"", ""source_assertion"": ""Rhea RHEA:22890 assigns CHEBI:57292 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22890']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/22888_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_22888_compound_4684']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:22890"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 22890 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-002_5b637066e8c2	RHEA:22890	pathwaymech:produces	CHEBI:57326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:22890		"[{""reference_id"": ""RHEA:22890"", ""source_assertion"": ""Rhea RHEA:22890 assigns CHEBI:57326 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/22890']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/22888_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_22888_compound_1391']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:22890"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 22890 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-003_7c9a0d7e4734	CHEBI:57326	pathwaymech:consumes	RHEA:27667	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27667	This is the current Rhea/UniProt (R)-specific annotation, not an enantiomer-resolved ScpB assay. PMID:28716098 reports epimerase dependence in engineered glucose/minimal-medium cultures. The conflict with the original coupled assay remains unresolved; no wild-type flux is asserted.	"[{""reference_id"": ""RHEA:27667"", ""source_assertion"": ""Rhea RHEA:27667 assigns CHEBI:57326 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27667']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27666_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27666_compound_1391']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27667"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27667 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-004_4b7219062a0c	CHEBI:15378	pathwaymech:consumes	RHEA:27667	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27667	This is the current Rhea/UniProt (R)-specific annotation, not an enantiomer-resolved ScpB assay. PMID:28716098 reports epimerase dependence in engineered glucose/minimal-medium cultures. The conflict with the original coupled assay remains unresolved; no wild-type flux is asserted.	"[{""reference_id"": ""RHEA:27667"", ""source_assertion"": ""Rhea RHEA:27667 assigns CHEBI:15378 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27667']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27666_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27666_compound_3249']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27667"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27667 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-005_4179fc0f1e83	RHEA:27667	pathwaymech:produces	CHEBI:57392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27667	This is the current Rhea/UniProt (R)-specific annotation, not an enantiomer-resolved ScpB assay. PMID:28716098 reports epimerase dependence in engineered glucose/minimal-medium cultures. The conflict with the original coupled assay remains unresolved; no wild-type flux is asserted.	"[{""reference_id"": ""RHEA:27667"", ""source_assertion"": ""Rhea RHEA:27667 assigns CHEBI:57392 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27667']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27666_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27666_compound_3421']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27667"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27667 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-006_4e1397a83bbb	RHEA:27667	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27667	This is the current Rhea/UniProt (R)-specific annotation, not an enantiomer-resolved ScpB assay. PMID:28716098 reports epimerase dependence in engineered glucose/minimal-medium cultures. The conflict with the original coupled assay remains unresolved; no wild-type flux is asserted.	"[{""reference_id"": ""RHEA:27667"", ""source_assertion"": ""Rhea RHEA:27667 assigns CHEBI:16526 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/27667']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/27666_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_27666_compound_4391']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:27667"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 27667 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-007_83a5753e6ef8	CHEBI:57392	pathwaymech:consumes	RHEA:28011	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28011		"[{""reference_id"": ""RHEA:28011"", ""source_assertion"": ""Rhea RHEA:28011 assigns CHEBI:57392 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28011']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28010_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28010_compound_3421']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28011"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28011 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-008_11a26e227137	CHEBI:30031	pathwaymech:consumes	RHEA:28011	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28011		"[{""reference_id"": ""RHEA:28011"", ""source_assertion"": ""Rhea RHEA:28011 assigns CHEBI:30031 to its substrates, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28011']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28010_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28010_compound_2501']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28011"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28011 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-009_d48661295016	RHEA:28011	pathwaymech:produces	CHEBI:17272	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28011		"[{""reference_id"": ""RHEA:28011"", ""source_assertion"": ""Rhea RHEA:28011 assigns CHEBI:17272 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28011']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28010_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28010_compound_4801']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28011"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28011 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-010_b8cfeca2fff3	RHEA:28011	pathwaymech:produces	CHEBI:57292	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28011		"[{""reference_id"": ""RHEA:28011"", ""source_assertion"": ""Rhea RHEA:28011 assigns CHEBI:57292 to its products, with coefficient 1 in rh:contains1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/28011']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/28010_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_28010_compound_4684']; rh:compound/rh:chebi""}]"	"[{""id"": ""RHEA:28011"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""142 (2026-09-02)"", ""title"": ""Rhea 28011 directional reaction"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-011_af01093f63a4	UniProtKB:P27253	BFO:0000050	MetaCyc:CPLX0-7741	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7741|MetaCyc:METHYLMALONYL-COA-MUT-MONOMER|PMID:18950999	Membership represents the annotated Sbm homodimer; it does not imply that all apo-Sbm is dimeric or include the distinct YgfD-bound assembly.	"[{""reference_id"": ""MetaCyc:CPLX0-7741"", ""source_assertion"": ""MetaCyc CPLX0-7741 contains 2 copies of METHYLMALONYL-COA-MUT-MONOMER and assigns the assembly to E. coli K-12 MG1655."", ""source_locator"": ""Protein[@frameid='CPLX0-7741']/component; species/Organism[@frameid='TAX-511145']""}, {""reference_id"": ""MetaCyc:METHYLMALONYL-COA-MUT-MONOMER"", ""source_assertion"": ""The native METHYLMALONYL-COA-MUT-MONOMER protein has a UniProt unification cross-reference to P27253."", ""source_locator"": ""Protein[@frameid='METHYLMALONYL-COA-MUT-MONOMER']/dblink[dblink-db='UNIPROT']/dblink-oid""}, {""reference_id"": ""PMID:18950999"", ""source_assertion"": ""Native PAGE and size exclusion detected apo-Sbm as a mixture of monomer and dimer."", ""source_locator"": ""Results, Interaction of YgfD and Sbm in vitro (P17); Figure 4B and Figure 4C, panel 2; Discussion""}]"	"[{""id"": ""MetaCyc:CPLX0-7741"", ""source_sha256"": ""f8aa687d9b17e35e238154abb6b33b224841a8d5801d0d5491d6fba3f63826a4"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc CPLX0-7741"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7741""}, {""id"": ""MetaCyc:METHYLMALONYL-COA-MUT-MONOMER"", ""source_sha256"": ""23658c5ce55d1ef5bcbface9fc0d054d451eb7e904ea4f15579bf139ba1ad953"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc METHYLMALONYL-COA-MUT-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:METHYLMALONYL-COA-MUT-MONOMER""}, {""id"": ""PMID:18950999"", ""source_sha256"": ""dfda3e02e329753cf3db0d38473e24b0c7a97555f411de1ee91a8a7bd308e013"", ""source_version"": ""Primary full text; retrieved 2026-10-10"", ""title"": ""Sleeping beauty mutase (sbm) is expressed and interacts with ygfD in Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2741639/?pdf=render""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-012_7e2a9a7e2179	UniProtKB:P52045	BFO:0000050	MetaCyc:CPLX0-254	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-254|MetaCyc:G7516-MONOMER|PMID:10769118		"[{""reference_id"": ""MetaCyc:CPLX0-254"", ""source_assertion"": ""MetaCyc CPLX0-254 contains 6 copies of G7516-MONOMER and assigns the assembly to E. coli K-12 MG1655."", ""source_locator"": ""Protein[@frameid='CPLX0-254']/component; species/Organism[@frameid='TAX-511145']""}, {""reference_id"": ""MetaCyc:G7516-MONOMER"", ""source_assertion"": ""The native G7516-MONOMER protein has a UniProt unification cross-reference to P52045."", ""source_locator"": ""Protein[@frameid='G7516-MONOMER']/dblink[dblink-db='UNIPROT']/dblink-oid""}, {""reference_id"": ""PMID:10769118"", ""source_assertion"": ""The E. coli decarboxylase crystal structure forms a hexamer arranged as two trimers."", ""source_locator"": ""Indexed abstract; oligomeric architecture""}]"	"[{""id"": ""MetaCyc:CPLX0-254"", ""source_sha256"": ""83a322ba0c7bb17d60f82bc95d21cbe0123b87365d623b7f9797d67304b6b06b"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc CPLX0-254"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-254""}, {""id"": ""MetaCyc:G7516-MONOMER"", ""source_sha256"": ""d2aab6d918014e4736ac58d2aa46f2d02648735d1b6474a333bd0ed5a3f053f3"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc G7516-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G7516-MONOMER""}, {""id"": ""PMID:10769118"", ""source_sha256"": ""d9ccd88e2de20db134af2d13aee3d42b8c86262c58db485f4f863722dc49fd33"", ""source_version"": ""Europe PMC core metadata and complete indexed abstract; retrieved 2026-10-10"", ""title"": ""New reactions in the crotonase superfamily: structure of methylmalonyl CoA decarboxylase from Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/10769118/""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-013_df3a43d6c652	MetaCyc:CPLX0-7741	pathwaymech:catalyzes	RHEA:22890	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7741|PMID:10769117|UniProtKB:P27253	RHEA:22890 selects the succinyl-CoA-to-(R)-methylmalonyl-CoA direction of the reversible mutase reaction for the proposed cycle.	"[{""reference_id"": ""MetaCyc:CPLX0-7741"", ""source_assertion"": ""MetaCyc CPLX0-7741 is the enzyme assigned to METHYLMALONYL-COA-MUT-RXN."", ""source_locator"": ""Protein[@frameid='CPLX0-7741']/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:P27253"", ""source_assertion"": ""Reviewed UniProt P27253 assigns (R)-methylmalonyl-CoA = succinyl-CoA (RHEA:22888; ECO:0000269, PMID:10769117)."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction""}, {""reference_id"": ""PMID:10769117"", ""source_assertion"": ""Adenosylcobalamin-reconstituted Sbm converted succinyl-CoA to propionyl-CoA in a coupled assay containing excess YgfG/ScpB."", ""source_locator"": ""pp. 4624-4625, Reconstitution and HPLC Assay of Sbm; p. 4627, Function of Sbm""}]"	"[{""id"": ""MetaCyc:CPLX0-7741"", ""source_sha256"": ""f8aa687d9b17e35e238154abb6b33b224841a8d5801d0d5491d6fba3f63826a4"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc CPLX0-7741"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7741""}, {""id"": ""PMID:10769117"", ""source_sha256"": ""d7a629eba85789aacbd57a4b813867c68f16e28d9ac9ef603ff40a4da9a40492"", ""source_version"": ""Primary full text; DOI 10.1021/bi992888d; retrieved 2026-10-10"", ""title"": ""Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli."", ""url"": ""https://static.igem.org/mediawiki/2013/c/c1/HUST-4.pdf""}, {""id"": ""UniProtKB:P27253"", ""source_sha256"": ""d0dae7669ab2c19e766695ac9f68754f8666c959e01219b8322513c34c27729d"", ""source_version"": ""2026_03; retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P27253"", ""url"": ""https://rest.uniprot.org/uniprotkb/P27253.json""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-014_e13b7008e0b4	MetaCyc:CPLX0-254	pathwaymech:catalyzes	RHEA:27667	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/jacs.9b00650.s001|MetaCyc:CPLX0-254|PMID:10769117|PMID:28716098|UniProtKB:P52045	This is the current Rhea/UniProt (R)-specific annotation, not an enantiomer-resolved ScpB assay. PMID:28716098 reports epimerase dependence in engineered glucose/minimal-medium cultures. The conflict with the original coupled assay remains unresolved; no wild-type flux is asserted. The 2019 assay used an R/S substrate mixture.	"[{""reference_id"": ""MetaCyc:CPLX0-254"", ""source_assertion"": ""MetaCyc CPLX0-254 is the enzyme assigned to RXN0-310."", ""source_locator"": ""Protein[@frameid='CPLX0-254']/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:P52045"", ""source_assertion"": ""Reviewed UniProt P52045 assigns (R)-methylmalonyl-CoA + H(+) = propanoyl-CoA + CO2 (RHEA:27666; ECO:0000269, PMID:10769117)."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction""}, {""reference_id"": ""PMID:10769117"", ""source_assertion"": ""Purified YgfG/ScpB catalyzed methylmalonyl-CoA decarboxylation; coupled Sbm/YgfG assays converted succinyl-CoA to propionyl-CoA."", ""source_locator"": ""p. 4626, Function of YgfG and Table 1; p. 4627, Function of Sbm""}, {""reference_id"": ""PMID:28716098"", ""source_assertion"": ""Engineered BL21 and DH5alpha cultures required heterologous methylmalonyl-CoA epimerase for propionate production from glucose in minimal medium; the paper questions ScpB stereospecificity."", ""source_locator"": ""Results, Heterologous PA production, epimerase co-expression; Discussion""}, {""reference_id"": ""DOI:10.1021/jacs.9b00650.s001"", ""source_assertion"": ""The 2019 MMCD-His6 assay used (R/S)-methylmalonyl-CoA and measured propionyl-CoA and free CoA. It supports decarboxylation plus hydrolysis without resolving ScpB enantiomer specificity."", ""source_locator"": ""Supporting Information, Section VIII pp. S14-S15; Figures S4-S5 pp. S27-S28""}]"	"[{""id"": ""DOI:10.1021/jacs.9b00650.s001"", ""source_sha256"": ""b979ec82a7ffc27790053dac5949f67c4bb99d91db827f6445bfb788b79aa1b2"", ""source_version"": ""ACS Figshare article 7863569, file 14641211; retrieved 2026-10-10"", ""title"": ""Supporting Information: Sulfonate/Nitro Bearing Methylmalonyl-Thioester Isosteres Applied to Methylmalonyl-CoA Decarboxylase Structure-Function Studies."", ""url"": ""https://ndownloader.figshare.com/files/14641211""}, {""id"": ""MetaCyc:CPLX0-254"", ""source_sha256"": ""83a322ba0c7bb17d60f82bc95d21cbe0123b87365d623b7f9797d67304b6b06b"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc CPLX0-254"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-254""}, {""id"": ""PMID:10769117"", ""source_sha256"": ""d7a629eba85789aacbd57a4b813867c68f16e28d9ac9ef603ff40a4da9a40492"", ""source_version"": ""Primary full text; DOI 10.1021/bi992888d; retrieved 2026-10-10"", ""title"": ""Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli."", ""url"": ""https://static.igem.org/mediawiki/2013/c/c1/HUST-4.pdf""}, {""id"": ""PMID:28716098"", ""source_sha256"": ""65cdfdcf56021b9e915e3013da82cc731379455e71df92a9e35ab35c167113cf"", ""source_version"": ""Primary full text; retrieved 2026-10-10"", ""title"": ""Awakening sleeping beauty: production of propionic acid in Escherichia coli through the sbm operon requires the activity of a methylmalonyl-CoA epimerase."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5512728/fullTextXML""}, {""id"": ""UniProtKB:P52045"", ""source_sha256"": ""49fb11dae7a00530346b65c5997b3cb23e9aa5603894b9e7d0b50f88a879fac1"", ""source_version"": ""2026_03; retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P52045"", ""url"": ""https://rest.uniprot.org/uniprotkb/P52045.json""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-015_fd670a5724ac	UniProtKB:P52043	pathwaymech:catalyzes	RHEA:28011	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:G7517-MONOMER|PMID:10769117|UniProtKB:P52043	RHEA:28011 selects the propionyl-CoA plus succinate direction of a reversible CoA transferase reaction; ScpC is represented by its protein identifier without an unsupported oligomeric state.	"[{""reference_id"": ""MetaCyc:G7517-MONOMER"", ""source_assertion"": ""MetaCyc G7517-MONOMER is the enzyme assigned to RXN0-268."", ""source_locator"": ""Protein[@frameid='G7517-MONOMER']/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:P52043"", ""source_assertion"": ""Reviewed UniProt P52043 assigns propanoyl-CoA + succinate = propanoate + succinyl-CoA (RHEA:28010; ECO:0000269, PMID:10769117)."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction""}, {""reference_id"": ""PMID:10769117"", ""source_assertion"": ""Purified YgfH/ScpC transferred CoA from propionyl-CoA to succinate in an HPLC assay."", ""source_locator"": ""p. 4624, HPLC Assay of YgfH; p. 4627, Function of YgfH""}]"	"[{""id"": ""MetaCyc:G7517-MONOMER"", ""source_sha256"": ""0167f442350d99cb4fe1056cf2990aa4af5096b6275d34156d802142a9194842"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc G7517-MONOMER"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G7517-MONOMER""}, {""id"": ""PMID:10769117"", ""source_sha256"": ""d7a629eba85789aacbd57a4b813867c68f16e28d9ac9ef603ff40a4da9a40492"", ""source_version"": ""Primary full text; DOI 10.1021/bi992888d; retrieved 2026-10-10"", ""title"": ""Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli."", ""url"": ""https://static.igem.org/mediawiki/2013/c/c1/HUST-4.pdf""}, {""id"": ""UniProtKB:P52043"", ""source_sha256"": ""6cc26a29ea9bac230e4e9a20d83e89cdb2d483619b627355ee983cac89e0bb05"", ""source_version"": ""2026_03; retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P52043"", ""url"": ""https://rest.uniprot.org/uniprotkb/P52043.json""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-016_3cc96a9ffa55	UniProtKB:P27253	pathwaymech:has_cofactor	CHEBI:18408	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:10769117|UniProtKB:P27253	CHEBI:18408 has canonical ChEBI label cobamamide; this is adenosylcobalamin, not a generic vitamin B12 pool or a consumed pathway substrate.	"[{""reference_id"": ""UniProtKB:P27253"", ""source_assertion"": ""Reviewed UniProt P27253 assigns adenosylcob(III)alamin (CHEBI:18408) as cofactor with ECO:0000269 citing PMID:10769117 and PMID:11955068."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors""}, {""reference_id"": ""PMID:10769117"", ""source_assertion"": ""Recombinant apo-Sbm was reconstituted with adenosylcobalamin before the mutase assay."", ""source_locator"": ""p. 4624, Reconstitution and HPLC Assay of Sbm; p. 4627, Function of Sbm""}]"	"[{""id"": ""PMID:10769117"", ""source_sha256"": ""d7a629eba85789aacbd57a4b813867c68f16e28d9ac9ef603ff40a4da9a40492"", ""source_version"": ""Primary full text; DOI 10.1021/bi992888d; retrieved 2026-10-10"", ""title"": ""Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli."", ""url"": ""https://static.igem.org/mediawiki/2013/c/c1/HUST-4.pdf""}, {""id"": ""UniProtKB:P27253"", ""source_sha256"": ""d0dae7669ab2c19e766695ac9f68754f8666c959e01219b8322513c34c27729d"", ""source_version"": ""2026_03; retrieved 2026-10-10"", ""title"": ""Reviewed UniProtKB P27253"", ""url"": ""https://rest.uniprot.org/uniprotkb/P27253.json""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-017_82b3dacbef0e	RHEA:22890	BFO:0000050	MetaCyc:PWY0-43	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:METHYLMALONYL-COA-MUT-RXN|MetaCyc:PWY0-43	Membership in the experimentally motivated biochemical proposal does not assert operation of a complete native cycle under unspecified growth conditions.	"[{""reference_id"": ""MetaCyc:PWY0-43"", ""source_assertion"": ""MetaCyc PWY0-43 lists METHYLMALONYL-COA-MUT-RXN in its three-reaction proposed succinate-to-propanoate cycle; its comment states that a metabolic role has not been shown."", ""source_locator"": ""Pathway[@frameid='PWY0-43']/reaction-list/Reaction[@frameid='METHYLMALONYL-COA-MUT-RXN']; comment""}, {""reference_id"": ""MetaCyc:METHYLMALONYL-COA-MUT-RXN"", ""source_assertion"": ""The native reaction METHYLMALONYL-COA-MUT-RXN has the chemical sides and Rhea cross-reference corresponding to this selected directional reaction."", ""source_locator"": ""Reaction[@frameid='METHYLMALONYL-COA-MUT-RXN']/left; right; reaction-direction; dblink[dblink-db='RHEA']""}]"	"[{""id"": ""MetaCyc:METHYLMALONYL-COA-MUT-RXN"", ""source_sha256"": ""322c68783b32c46bc6c9ba48baec241cbfc708fb7f2ace8dbff6dc501a12216e"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc METHYLMALONYL-COA-MUT-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:METHYLMALONYL-COA-MUT-RXN""}, {""id"": ""MetaCyc:PWY0-43"", ""source_sha256"": ""4a16c5ff09d436aacfe989620832fbda176740ab625ca479dbc2612eae11a151"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc PWY0-43"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-43""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-018_bb6a355429b9	RHEA:27667	BFO:0000050	MetaCyc:PWY0-43	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-43|MetaCyc:RXN0-310	Membership in the experimentally motivated biochemical proposal does not assert operation of a complete native cycle under unspecified growth conditions.	"[{""reference_id"": ""MetaCyc:PWY0-43"", ""source_assertion"": ""MetaCyc PWY0-43 lists RXN0-310 in its three-reaction proposed succinate-to-propanoate cycle; its comment states that a metabolic role has not been shown."", ""source_locator"": ""Pathway[@frameid='PWY0-43']/reaction-list/Reaction[@frameid='RXN0-310']; comment""}, {""reference_id"": ""MetaCyc:RXN0-310"", ""source_assertion"": ""The native reaction RXN0-310 has the chemical sides and Rhea cross-reference corresponding to this selected directional reaction."", ""source_locator"": ""Reaction[@frameid='RXN0-310']/left; right; reaction-direction; dblink[dblink-db='RHEA']""}]"	"[{""id"": ""MetaCyc:PWY0-43"", ""source_sha256"": ""4a16c5ff09d436aacfe989620832fbda176740ab625ca479dbc2612eae11a151"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc PWY0-43"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-43""}, {""id"": ""MetaCyc:RXN0-310"", ""source_sha256"": ""e1ac85a526f25f0e652af5f902831544bd3b2da20093441f09c69a59d10306a3"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc RXN0-310"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-310""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-019_f1c2605f586e	RHEA:28011	BFO:0000050	MetaCyc:PWY0-43	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-43|MetaCyc:RXN0-268	Membership in the experimentally motivated biochemical proposal does not assert operation of a complete native cycle under unspecified growth conditions.	"[{""reference_id"": ""MetaCyc:PWY0-43"", ""source_assertion"": ""MetaCyc PWY0-43 lists RXN0-268 in its three-reaction proposed succinate-to-propanoate cycle; its comment states that a metabolic role has not been shown."", ""source_locator"": ""Pathway[@frameid='PWY0-43']/reaction-list/Reaction[@frameid='RXN0-268']; comment""}, {""reference_id"": ""MetaCyc:RXN0-268"", ""source_assertion"": ""The native reaction RXN0-268 has the chemical sides and Rhea cross-reference corresponding to this selected directional reaction."", ""source_locator"": ""Reaction[@frameid='RXN0-268']/left; right; reaction-direction; dblink[dblink-db='RHEA']""}]"	"[{""id"": ""MetaCyc:PWY0-43"", ""source_sha256"": ""4a16c5ff09d436aacfe989620832fbda176740ab625ca479dbc2612eae11a151"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc PWY0-43"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-43""}, {""id"": ""MetaCyc:RXN0-268"", ""source_sha256"": ""fa32ebd19455f13f6ae34cbc06bef5c04cbeaf943b6f8096295fe08574957f36"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc RXN0-268"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-268""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-020_4c2bd86a2755	RHEA:22890	RO:0002413	RHEA:27667	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-43	This is the current Rhea/UniProt (R)-specific annotation, not an enantiomer-resolved ScpB assay. PMID:28716098 reports epimerase dependence in engineered glucose/minimal-medium cultures. The conflict with the original coupled assay remains unresolved; no wild-type flux is asserted.	"[{""reference_id"": ""MetaCyc:PWY0-43"", ""source_assertion"": ""Native PWY0-43 reaction order places METHYLMALONYL-COA-MUT-RXN before RXN0-310 in the proposed cycle, sharing (R)-methylmalonyl-CoA."", ""source_locator"": ""Pathway[@frameid='PWY0-43']/reaction-ordering[Reaction[@frameid='RXN0-310'] and predecessor-reactions/Reaction[@frameid='METHYLMALONYL-COA-MUT-RXN']]; reaction-layout""}]"	"[{""id"": ""MetaCyc:PWY0-43"", ""source_sha256"": ""4a16c5ff09d436aacfe989620832fbda176740ab625ca479dbc2612eae11a151"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc PWY0-43"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-43""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-021_a9125cf59b96	RHEA:27667	RO:0002413	RHEA:28011	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-43	This edge records the native biochemical-cycle layout, not measured wild-type flux or an additional physiological inference.	"[{""reference_id"": ""MetaCyc:PWY0-43"", ""source_assertion"": ""Native PWY0-43 reaction order places RXN0-310 before RXN0-268 in the proposed cycle, sharing propionyl-CoA."", ""source_locator"": ""Pathway[@frameid='PWY0-43']/reaction-ordering[Reaction[@frameid='RXN0-268'] and predecessor-reactions/Reaction[@frameid='RXN0-310']]; reaction-layout""}]"	"[{""id"": ""MetaCyc:PWY0-43"", ""source_sha256"": ""4a16c5ff09d436aacfe989620832fbda176740ab625ca479dbc2612eae11a151"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc PWY0-43"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-43""}]"	""
pathwaymech:MetaCyc_PWY0-43_sbm-edge-022_cc8f610e372b	RHEA:28011	RO:0002413	RHEA:22890	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-43	This edge records the native biochemical-cycle layout, not measured wild-type flux or an additional physiological inference.	"[{""reference_id"": ""MetaCyc:PWY0-43"", ""source_assertion"": ""Native PWY0-43 reaction order places RXN0-268 before METHYLMALONYL-COA-MUT-RXN in the proposed cycle, sharing succinyl-CoA."", ""source_locator"": ""Pathway[@frameid='PWY0-43']/reaction-ordering[Reaction[@frameid='METHYLMALONYL-COA-MUT-RXN'] and predecessor-reactions/Reaction[@frameid='RXN0-268']]; reaction-layout""}]"	"[{""id"": ""MetaCyc:PWY0-43"", ""source_sha256"": ""4a16c5ff09d436aacfe989620832fbda176740ab625ca479dbc2612eae11a151"", ""source_version"": ""22.5; official mirror retrieved 2026-10-10"", ""title"": ""MetaCyc PWY0-43"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-43""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5340_edge-001_443796b2908a	gomodel:ADENYLYLSULFKIN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5340		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5340"", ""source_assertion"": ""The model asserts gomodel:ADENYLYLSULFKIN-RXN BFO:0000066 gomodel:reaction_ADENYLYLSULFKIN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5340.json#/facts/0; endpoint types: /individuals/0/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5340"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5340.json"", ""title"": ""SGD GO-CAM sulfate activation (for sulfonation) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5340_edge-002_e98e64386723	gomodel:SULFATE-ADENYLYLTRANS-RXN	RO:0002234	CHEBI:58243	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5340		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5340"", ""source_assertion"": ""The model asserts gomodel:SULFATE-ADENYLYLTRANS-RXN RO:0002234 gomodel:CHEBI_58243_SULFATE-ADENYLYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY-5340.json#/facts/1; endpoint types: /individuals/10/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5340"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5340.json"", ""title"": ""SGD GO-CAM sulfate activation (for sulfonation) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5340_edge-003_82388fd16cdb	SGD:S000001484	pathwaymech:enables	gomodel:ADENYLYLSULFKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5340		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5340"", ""source_assertion"": ""The model asserts gomodel:ADENYLYLSULFKIN-RXN RO:0002333 gomodel:YKL001C-MONOMER_ADENYLYLSULFKIN-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5340.json#/facts/2; endpoint types: /individuals/0/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5340"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5340.json"", ""title"": ""SGD GO-CAM sulfate activation (for sulfonation) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5340_edge-004_5f2237dad49d	gomodel:SULFATE-ADENYLYLTRANS-RXN	RO:0002413	gomodel:ADENYLYLSULFKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5340		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5340"", ""source_assertion"": ""The model asserts gomodel:SULFATE-ADENYLYLTRANS-RXN RO:0002413 gomodel:ADENYLYLSULFKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5340.json#/facts/3; endpoint types: /individuals/10/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5340"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5340.json"", ""title"": ""SGD GO-CAM sulfate activation (for sulfonation) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5340_edge-005_5af3e1afc31d	gomodel:SULFATE-ADENYLYLTRANS-RXN	RO:0002233	CHEBI:16189	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5340		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5340"", ""source_assertion"": ""The model asserts gomodel:SULFATE-ADENYLYLTRANS-RXN RO:0002233 gomodel:CHEBI_16189_SULFATE-ADENYLYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY-5340.json#/facts/4; endpoint types: /individuals/10/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5340"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5340.json"", ""title"": ""SGD GO-CAM sulfate activation (for sulfonation) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5340_edge-006_6b92a4c85365	gomodel:ADENYLYLSULFKIN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5340		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5340"", ""source_assertion"": ""The model asserts gomodel:ADENYLYLSULFKIN-RXN RO:0002234 gomodel:CHEBI_15378_ADENYLYLSULFKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5340.json#/facts/5; endpoint types: /individuals/0/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5340"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5340.json"", ""title"": ""SGD GO-CAM sulfate activation (for sulfonation) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5340_edge-007_8b64aebe176b	gomodel:ADENYLYLSULFKIN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5340		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5340"", ""source_assertion"": ""The model asserts gomodel:ADENYLYLSULFKIN-RXN RO:0002233 gomodel:CHEBI_30616_ADENYLYLSULFKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5340.json#/facts/6; endpoint types: /individuals/0/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5340"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5340.json"", ""title"": ""SGD GO-CAM sulfate activation (for sulfonation) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5340_edge-008_881a088d98f7	gomodel:SULFATE-ADENYLYLTRANS-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5340		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5340"", ""source_assertion"": ""The model asserts gomodel:SULFATE-ADENYLYLTRANS-RXN BFO:0000066 gomodel:reaction_SULFATE-ADENYLYLTRANS-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5340.json#/facts/7; endpoint types: /individuals/10/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5340"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5340.json"", ""title"": ""SGD GO-CAM sulfate activation (for sulfonation) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5340_edge-009_05155b53cf49	SGD:S000003771	pathwaymech:enables	gomodel:SULFATE-ADENYLYLTRANS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5340		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5340"", ""source_assertion"": ""The model asserts gomodel:SULFATE-ADENYLYLTRANS-RXN RO:0002333 gomodel:YJR010W-MONOMER_SULFATE-ADENYLYLTRANS-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5340.json#/facts/8; endpoint types: /individuals/10/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5340"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5340.json"", ""title"": ""SGD GO-CAM sulfate activation (for sulfonation) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5340_edge-010_6c6e6f5b497c	gomodel:SULFATE-ADENYLYLTRANS-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5340		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5340"", ""source_assertion"": ""The model asserts gomodel:SULFATE-ADENYLYLTRANS-RXN RO:0002233 gomodel:CHEBI_15378_SULFATE-ADENYLYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY-5340.json#/facts/9; endpoint types: /individuals/10/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5340"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5340.json"", ""title"": ""SGD GO-CAM sulfate activation (for sulfonation) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5340_edge-011_ae8379edfd06	gomodel:ADENYLYLSULFKIN-RXN	RO:0002234	CHEBI:58339	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5340		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5340"", ""source_assertion"": ""The model asserts gomodel:ADENYLYLSULFKIN-RXN RO:0002234 gomodel:CHEBI_58339_ADENYLYLSULFKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5340.json#/facts/10; endpoint types: /individuals/0/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5340"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5340.json"", ""title"": ""SGD GO-CAM sulfate activation (for sulfonation) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5340_edge-012_8c6c6953e2f3	gomodel:ADENYLYLSULFKIN-RXN	BFO:0000050	GO:0050427	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5340		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5340"", ""source_assertion"": ""The model asserts gomodel:ADENYLYLSULFKIN-RXN BFO:0000050 gomodel:YeastPathways_PWY-5340/YeastPathways_PWY-5340."", ""source_locator"": ""./YeastPathways_PWY-5340.json#/facts/11; endpoint types: /individuals/0/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5340"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5340.json"", ""title"": ""SGD GO-CAM sulfate activation (for sulfonation) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5340_edge-013_744fb5be4e82	gomodel:SULFATE-ADENYLYLTRANS-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5340		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5340"", ""source_assertion"": ""The model asserts gomodel:SULFATE-ADENYLYLTRANS-RXN RO:0002233 gomodel:CHEBI_30616_SULFATE-ADENYLYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY-5340.json#/facts/12; endpoint types: /individuals/10/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5340"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5340.json"", ""title"": ""SGD GO-CAM sulfate activation (for sulfonation) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5340_edge-014_c3e26eda1b99	gomodel:SULFATE-ADENYLYLTRANS-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5340		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5340"", ""source_assertion"": ""The model asserts gomodel:SULFATE-ADENYLYLTRANS-RXN RO:0002234 gomodel:CHEBI_29888_SULFATE-ADENYLYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY-5340.json#/facts/13; endpoint types: /individuals/10/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5340"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5340.json"", ""title"": ""SGD GO-CAM sulfate activation (for sulfonation) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5340_edge-015_e64d419fe730	gomodel:ADENYLYLSULFKIN-RXN	RO:0002233	CHEBI:58243	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5340		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5340"", ""source_assertion"": ""The model asserts gomodel:ADENYLYLSULFKIN-RXN RO:0002233 gomodel:CHEBI_58243_SULFATE-ADENYLYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_PWY-5340.json#/facts/14; endpoint types: /individuals/0/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5340"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5340.json"", ""title"": ""SGD GO-CAM sulfate activation (for sulfonation) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5340_edge-016_c874925f5f16	gomodel:ADENYLYLSULFKIN-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5340		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5340"", ""source_assertion"": ""The model asserts gomodel:ADENYLYLSULFKIN-RXN RO:0002234 gomodel:CHEBI_456216_ADENYLYLSULFKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5340.json#/facts/15; endpoint types: /individuals/0/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5340"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5340.json"", ""title"": ""SGD GO-CAM sulfate activation (for sulfonation) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5340_edge-017_d2aba16c6ed2	gomodel:SULFATE-ADENYLYLTRANS-RXN	BFO:0000050	GO:0050427	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5340		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5340"", ""source_assertion"": ""The model asserts gomodel:SULFATE-ADENYLYLTRANS-RXN BFO:0000050 gomodel:YeastPathways_PWY-5340/YeastPathways_PWY-5340."", ""source_locator"": ""./YeastPathways_PWY-5340.json#/facts/16; endpoint types: /individuals/10/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5340"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY-5340.json"", ""title"": ""SGD GO-CAM sulfate activation (for sulfonation) - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5340_location-99241a05b311_e00a4b0c20bb	SGD:S000003771	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08536	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03106); ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P08536"", ""source_assertion"": ""UniProtKB:P08536 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/211/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P08536"", ""source_assertion"": ""UniProtKB:P08536 has the exact SGD cross-reference SGD:S000003771."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/211/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P08536"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P08536 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-001_5eead37a2f7c	CHEBI:142957	pathwaymech:consumes	RHEA:40440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40440		"[{""reference_id"": ""RHEA:40440"", ""source_assertion"": ""RHEA:40440 assigns CHEBI:142957 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40440']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40439_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40439_compound_15317']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_15317)""}]"	"[{""id"": ""RHEA:40440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40440 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-002_552b223d56a8	RHEA:40440	pathwaymech:produces	CHEBI:77133	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40440		"[{""reference_id"": ""RHEA:40440"", ""source_assertion"": ""RHEA:40440 assigns CHEBI:77133 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40440']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40439_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40439_compound_9102']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_9102)""}]"	"[{""id"": ""RHEA:40440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40440 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-003_53818420b19b	CHEBI:77133	pathwaymech:consumes	RHEA:40444	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40444		"[{""reference_id"": ""RHEA:40444"", ""source_assertion"": ""RHEA:40444 assigns CHEBI:77133 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40444']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40443_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40443_compound_9102']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_9102)""}]"	"[{""id"": ""RHEA:40444"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40444 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-004_a479ad8591e7	CHEBI:30616	pathwaymech:consumes	RHEA:40444	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40444		"[{""reference_id"": ""RHEA:40444"", ""source_assertion"": ""RHEA:40444 assigns CHEBI:30616 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40444']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40443_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40443_compound_6372']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_6372)""}]"	"[{""id"": ""RHEA:40444"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40444 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-005_707f7dcd37fc	RHEA:40444	pathwaymech:produces	CHEBI:77134	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40444		"[{""reference_id"": ""RHEA:40444"", ""source_assertion"": ""RHEA:40444 assigns CHEBI:77134 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40444']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40443_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40443_compound_9103']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_9103)""}]"	"[{""id"": ""RHEA:40444"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40444 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-006_47f0a512edee	RHEA:40444	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40444		"[{""reference_id"": ""RHEA:40444"", ""source_assertion"": ""RHEA:40444 assigns CHEBI:456216 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40444']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40443_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40443_compound_2710']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_2710)""}]"	"[{""id"": ""RHEA:40444"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40444 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-007_f011143f9bfa	RHEA:40444	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40444		"[{""reference_id"": ""RHEA:40444"", ""source_assertion"": ""RHEA:40444 assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40444']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40443_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40443_compound_3249']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3249)""}]"	"[{""id"": ""RHEA:40444"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40444 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-008_d833fabd67d0	CHEBI:77134	pathwaymech:consumes	RHEA:40516	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40516		"[{""reference_id"": ""RHEA:40516"", ""source_assertion"": ""RHEA:40516 assigns CHEBI:77134 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40516']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40515_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40515_compound_9103']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_9103)""}]"	"[{""id"": ""RHEA:40516"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40516 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-009_f6733c48cf14	RHEA:40516	pathwaymech:produces	CHEBI:90109	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40516		"[{""reference_id"": ""RHEA:40516"", ""source_assertion"": ""RHEA:40516 assigns CHEBI:90109 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40516']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40515_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40515_compound_12045']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_12045)""}]"	"[{""id"": ""RHEA:40516"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40516 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-010_eab4becca022	RHEA:40516	pathwaymech:produces	CHEBI:57642	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40516		"[{""reference_id"": ""RHEA:40516"", ""source_assertion"": ""RHEA:40516 assigns CHEBI:57642 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40516']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40515_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40515_compound_4255']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_4255)""}]"	"[{""id"": ""RHEA:40516"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40516 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-011_1e20d44331d2	CHEBI:90109	pathwaymech:consumes	RHEA:40513	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40513		"[{""reference_id"": ""RHEA:40513"", ""source_assertion"": ""RHEA:40513 assigns CHEBI:90109 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40513']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40511_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40511_compound_12045']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_12045)""}]"	"[{""id"": ""RHEA:40513"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40513 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-012_66d5c5a96862	CHEBI:57945	pathwaymech:consumes	RHEA:40513	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40513		"[{""reference_id"": ""RHEA:40513"", ""source_assertion"": ""RHEA:40513 assigns CHEBI:57945 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40513']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40511_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40511_compound_1650']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_1650)""}]"	"[{""id"": ""RHEA:40513"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40513 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-013_d660eb2f35fc	CHEBI:15378	pathwaymech:consumes	RHEA:40513	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40513		"[{""reference_id"": ""RHEA:40513"", ""source_assertion"": ""RHEA:40513 assigns CHEBI:15378 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40513']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40511_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40511_compound_3249']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3249)""}]"	"[{""id"": ""RHEA:40513"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40513 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-014_14f0fbf1eae1	RHEA:40513	pathwaymech:produces	CHEBI:176527	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40513		"[{""reference_id"": ""RHEA:40513"", ""source_assertion"": ""RHEA:40513 assigns CHEBI:176527 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40513']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40511_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40511_compound_17525']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_17525)""}]"	"[{""id"": ""RHEA:40513"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40513 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-015_f9002e590a5b	RHEA:40513	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:40513		"[{""reference_id"": ""RHEA:40513"", ""source_assertion"": ""RHEA:40513 assigns CHEBI:57540 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40513']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40511_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40511_compound_3484']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3484)""}]"	"[{""id"": ""RHEA:40513"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40513 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-016_5cb9b2a4bde9	RHEA:40440	BFO:0000050	MetaCyc:PWY-7446	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7446|MetaCyc:RXN-15296|PMID:24463506|RHEA:40440		"[{""reference_id"": ""MetaCyc:PWY-7446"", ""source_assertion"": ""The native pathway lists RXN-15296 as a member."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-7446\""]/reaction-list/Reaction[@frameid=\""RXN-15296\""]""}, {""reference_id"": ""MetaCyc:RXN-15296"", ""source_assertion"": ""The native reaction explicitly cross-references RHEA:40440."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-15296\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:40440"", ""source_assertion"": ""Rhea family 40439 contains directed reaction 40440, whose physiological side assignment is used here."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/40439\""]/rh:directionalReaction[@rdf:resource=\""http://rdf.rhea-db.org/40440\""]; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/40440\""]/rh:substrates and rh:products""}, {""reference_id"": ""PMID:24463506"", ""source_assertion"": ""K-12 substrains grew aerobically on SQ; MG1655 proteomics and recombinant four-enzyme reconstitution supported the route. BW25113 yihS, yihT and yihV deletions failed to grow on SQ."", ""source_locator"": ""Printed pp114-116; Figure 2 and Figure 3; Methods, Bacteria and growth conditions and Heterologous expression and purification""}]"	"[{""id"": ""MetaCyc:PWY-7446"", ""source_sha256"": ""7970734efae9b0f74c4e6ba1caa7af6b4a498a21d37e5c22b603347747b0d341"", ""source_version"": ""MetaCyc 22.5 public mirror; complete native XML response retrieved 2026-10-11"", ""title"": ""sulfoquinovose degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7446""}, {""id"": ""MetaCyc:RXN-15296"", ""source_sha256"": ""96df0a7e5f9a73bb19389fcba8051ec358886724dda1fd78a0901983640538bb"", ""source_version"": ""MetaCyc 22.5 public mirror; complete native XML response retrieved 2026-10-11"", ""title"": ""RXN-15296"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-15296""}, {""id"": ""PMID:24463506"", ""source_sha256"": ""e3c80fff89a548b26f8de5578e100c17c995e098243256d5f3d96058809aa61d"", ""source_version"": ""Original 2014 Nature article with Methods and Extended Data; SHA256 covers complete 15-page institutional PDF"", ""title"": ""Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle."", ""url"": ""https://kops.uni-konstanz.de/bitstream/123456789/26077/2/Denger_260772.pdf""}, {""id"": ""RHEA:40440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40440 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-017_d66ba88cc822	RHEA:40444	BFO:0000050	MetaCyc:PWY-7446	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7446|MetaCyc:RXN-15297|RHEA:40444		"[{""reference_id"": ""MetaCyc:PWY-7446"", ""source_assertion"": ""The native pathway lists RXN-15297 as a member."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-7446\""]/reaction-list/Reaction[@frameid=\""RXN-15297\""]""}, {""reference_id"": ""MetaCyc:RXN-15297"", ""source_assertion"": ""The native reaction explicitly cross-references RHEA:40444."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-15297\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:40444"", ""source_assertion"": ""Rhea family 40443 contains directed reaction 40444, whose physiological side assignment is used here."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/40443\""]/rh:directionalReaction[@rdf:resource=\""http://rdf.rhea-db.org/40444\""]; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/40444\""]/rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:PWY-7446"", ""source_sha256"": ""7970734efae9b0f74c4e6ba1caa7af6b4a498a21d37e5c22b603347747b0d341"", ""source_version"": ""MetaCyc 22.5 public mirror; complete native XML response retrieved 2026-10-11"", ""title"": ""sulfoquinovose degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7446""}, {""id"": ""MetaCyc:RXN-15297"", ""source_sha256"": ""de68618628cc2cb713a1ded6b3fa52672882d77a1394da05a6ad87dab70c0f90"", ""source_version"": ""MetaCyc 22.5 public mirror; complete native XML response retrieved 2026-10-11"", ""title"": ""RXN-15297"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-15297""}, {""id"": ""RHEA:40444"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40444 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-018_d34bf7f2b2a6	RHEA:40516	BFO:0000050	MetaCyc:PWY-7446	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7446|MetaCyc:RXN-15298|RHEA:40516		"[{""reference_id"": ""MetaCyc:PWY-7446"", ""source_assertion"": ""The native pathway lists RXN-15298 as a member."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-7446\""]/reaction-list/Reaction[@frameid=\""RXN-15298\""]""}, {""reference_id"": ""MetaCyc:RXN-15298"", ""source_assertion"": ""The native reaction explicitly cross-references RHEA:40516."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-15298\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:40516"", ""source_assertion"": ""Rhea family 40515 contains directed reaction 40516, whose physiological side assignment is used here."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/40515\""]/rh:directionalReaction[@rdf:resource=\""http://rdf.rhea-db.org/40516\""]; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/40516\""]/rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:PWY-7446"", ""source_sha256"": ""7970734efae9b0f74c4e6ba1caa7af6b4a498a21d37e5c22b603347747b0d341"", ""source_version"": ""MetaCyc 22.5 public mirror; complete native XML response retrieved 2026-10-11"", ""title"": ""sulfoquinovose degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7446""}, {""id"": ""MetaCyc:RXN-15298"", ""source_sha256"": ""90fb6eecfed959e2a169933f975777b9829bd0695166754d360fb4a75d346bed"", ""source_version"": ""MetaCyc 22.5 public mirror; complete native XML response retrieved 2026-10-11"", ""title"": ""RXN-15298"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-15298""}, {""id"": ""RHEA:40516"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40516 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-019_9d548ad77ba6	RHEA:40513	BFO:0000050	MetaCyc:PWY-7446	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7446|MetaCyc:RXN-15299|RHEA:40513		"[{""reference_id"": ""MetaCyc:PWY-7446"", ""source_assertion"": ""The native pathway lists RXN-15299 as a member."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-7446\""]/reaction-list/Reaction[@frameid=\""RXN-15299\""]""}, {""reference_id"": ""MetaCyc:RXN-15299"", ""source_assertion"": ""The native reaction explicitly cross-references RHEA:40513."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-15299\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:40513"", ""source_assertion"": ""Rhea family 40511 contains directed reaction 40513, whose physiological side assignment is used here."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/40511\""]/rh:directionalReaction[@rdf:resource=\""http://rdf.rhea-db.org/40513\""]; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/40513\""]/rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:PWY-7446"", ""source_sha256"": ""7970734efae9b0f74c4e6ba1caa7af6b4a498a21d37e5c22b603347747b0d341"", ""source_version"": ""MetaCyc 22.5 public mirror; complete native XML response retrieved 2026-10-11"", ""title"": ""sulfoquinovose degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7446""}, {""id"": ""MetaCyc:RXN-15299"", ""source_sha256"": ""ec99597471d7069673adfb967254620c98172bec9dbb83d5785ed0709b8eca72"", ""source_version"": ""MetaCyc 22.5 public mirror; complete native XML response retrieved 2026-10-11"", ""title"": ""RXN-15299"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-15299""}, {""id"": ""RHEA:40513"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40513 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-020_6323ba08e3a6	RHEA:40440	RO:0002413	RHEA:40444	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7446|RHEA:40440|RHEA:40444	The connected reactions share CHEBI:77133; this is material transfer, not a claim that the enzyme reactions are thermodynamically irreversible.	"[{""reference_id"": ""MetaCyc:PWY-7446"", ""source_assertion"": ""Native reaction ordering places RXN-15296 before RXN-15297."", ""source_locator"": ""/ptools-xml/Pathway/reaction-ordering[Reaction/@frameid=\""RXN-15297\""]/predecessor-reactions/Reaction[@frameid=\""RXN-15296\""]""}, {""reference_id"": ""RHEA:40440"", ""source_assertion"": ""RHEA:40440 assigns CHEBI:77133 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40440']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40439_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40439_compound_9102']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_9102)""}, {""reference_id"": ""RHEA:40444"", ""source_assertion"": ""RHEA:40444 assigns CHEBI:77133 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40444']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40443_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40443_compound_9102']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_9102)""}]"	"[{""id"": ""MetaCyc:PWY-7446"", ""source_sha256"": ""7970734efae9b0f74c4e6ba1caa7af6b4a498a21d37e5c22b603347747b0d341"", ""source_version"": ""MetaCyc 22.5 public mirror; complete native XML response retrieved 2026-10-11"", ""title"": ""sulfoquinovose degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7446""}, {""id"": ""RHEA:40440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40440 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:40444"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40444 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-021_208faea7078c	RHEA:40444	RO:0002413	RHEA:40516	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7446|RHEA:40444|RHEA:40516	The connected reactions share CHEBI:77134; this is material transfer, not a claim that the enzyme reactions are thermodynamically irreversible.	"[{""reference_id"": ""MetaCyc:PWY-7446"", ""source_assertion"": ""Native reaction ordering places RXN-15297 before RXN-15298."", ""source_locator"": ""/ptools-xml/Pathway/reaction-ordering[Reaction/@frameid=\""RXN-15298\""]/predecessor-reactions/Reaction[@frameid=\""RXN-15297\""]""}, {""reference_id"": ""RHEA:40444"", ""source_assertion"": ""RHEA:40444 assigns CHEBI:77134 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40444']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40443_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40443_compound_9103']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_9103)""}, {""reference_id"": ""RHEA:40516"", ""source_assertion"": ""RHEA:40516 assigns CHEBI:77134 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40516']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40515_L']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40515_compound_9103']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_9103)""}]"	"[{""id"": ""MetaCyc:PWY-7446"", ""source_sha256"": ""7970734efae9b0f74c4e6ba1caa7af6b4a498a21d37e5c22b603347747b0d341"", ""source_version"": ""MetaCyc 22.5 public mirror; complete native XML response retrieved 2026-10-11"", ""title"": ""sulfoquinovose degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7446""}, {""id"": ""RHEA:40444"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40444 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:40516"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40516 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-022_f1cea5479f7e	RHEA:40516	RO:0002413	RHEA:40513	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7446|RHEA:40513|RHEA:40516	The connected reactions share CHEBI:90109; this is material transfer, not a claim that the enzyme reactions are thermodynamically irreversible.	"[{""reference_id"": ""MetaCyc:PWY-7446"", ""source_assertion"": ""Native reaction ordering places RXN-15298 before RXN-15299."", ""source_locator"": ""/ptools-xml/Pathway/reaction-ordering[Reaction/@frameid=\""RXN-15299\""]/predecessor-reactions/Reaction[@frameid=\""RXN-15298\""]""}, {""reference_id"": ""RHEA:40516"", ""source_assertion"": ""RHEA:40516 assigns CHEBI:90109 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40516']/rh:products; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40515_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40515_compound_12045']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_12045)""}, {""reference_id"": ""RHEA:40513"", ""source_assertion"": ""RHEA:40513 assigns CHEBI:90109 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/40513']/rh:substrates; rdf:Description[@rdf:about='http://rdf.rhea-db.org/40511_R']/rh:contains1[@rdf:resource='http://rdf.rhea-db.org/Participant_40511_compound_12045']; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_12045)""}]"	"[{""id"": ""MetaCyc:PWY-7446"", ""source_sha256"": ""7970734efae9b0f74c4e6ba1caa7af6b4a498a21d37e5c22b603347747b0d341"", ""source_version"": ""MetaCyc 22.5 public mirror; complete native XML response retrieved 2026-10-11"", ""title"": ""sulfoquinovose degradation I"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7446""}, {""id"": ""RHEA:40513"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40513 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:40516"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; SHA256 covers complete official compressed RDF gzip"", ""title"": ""Rhea 142 directed reaction 40516 and family"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-023_530a20f15c76	UniProtKB:P32140	BFO:0000050	MetaCyc:CPLX0-7683	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7683|MetaCyc:EG11845-MONOMER|UniProtKB:P32140	Assembly composition is 6 copies; the protein membership edge does not assert independent monomer catalysis.	"[{""reference_id"": ""MetaCyc:CPLX0-7683"", ""source_assertion"": ""The native assembly has 6 copies of EG11845-MONOMER."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""CPLX0-7683\""]/component[Protein/@frameid=\""EG11845-MONOMER\""]/coefficient""}, {""reference_id"": ""MetaCyc:EG11845-MONOMER"", ""source_assertion"": ""The native protein maps to UniProt P32140 and belongs to CPLX0-7683."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""EG11845-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]; component-of""}, {""reference_id"": ""UniProtKB:P32140"", ""source_assertion"": ""ECO:0000255; The reviewed entry annotates a homohexamer, with HAMAP and PMID18328504 evidence."", ""source_locator"": ""/comments/5/texts""}]"	"[{""id"": ""MetaCyc:CPLX0-7683"", ""source_sha256"": ""bdeeb46a5fd6bde252e6057c0c9ffd780bb4d737e1050521c46800de83b62961"", ""source_version"": ""MetaCyc 22.5 public mirror; complete native XML response retrieved 2026-10-11"", ""title"": ""sulfoquinovose isomerase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7683""}, {""id"": ""MetaCyc:EG11845-MONOMER"", ""source_sha256"": ""47fbec47d1e304624a431a7b0cd18798cb5330478c1fe6590e21abfa2283a7ad"", ""source_version"": ""MetaCyc 22.5 public mirror; complete native XML response retrieved 2026-10-11"", ""title"": ""sulfoquinovose isomerase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:EG11845-MONOMER""}, {""id"": ""UniProtKB:P32140"", ""source_sha256"": ""20ad003895196c86a8af23d588466a45cbc0e86056bbc89a976c69e555ae0407"", ""source_version"": ""UniProt 2026_03 (02-September-2026); complete original entry JSON retrieved 2026-10-11"", ""title"": ""Sulfoquinovose isomerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P32140.json""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-024_163dfa9d9e43	UniProtKB:P0A9V8	BFO:0000050	MetaCyc:CPLX0-7794	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/acscatal.9b04427|MetaCyc:CPLX0-7794|MetaCyc:EG11847-MONOMER	Assembly composition is 4 copies; the protein membership edge does not assert independent monomer catalysis.	"[{""reference_id"": ""MetaCyc:CPLX0-7794"", ""source_assertion"": ""The native assembly has 4 copies of EG11847-MONOMER."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""CPLX0-7794\""]/component[Protein/@frameid=\""EG11847-MONOMER\""]/coefficient""}, {""reference_id"": ""MetaCyc:EG11847-MONOMER"", ""source_assertion"": ""The native protein maps to UniProt P0A9V8 and belongs to CPLX0-7794."", ""source_locator"": ""/ptools-xml/Protein[@frameid=\""EG11847-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]; component-of""}, {""reference_id"": ""DOI:10.1021/acscatal.9b04427"", ""source_assertion"": ""E. coli YihU crystallized as a dimer of dimers, and SEC-MALS confirmed a solution tetramer. The active site spans the intimate dimer interface."", ""source_locator"": ""Accepted manuscript printed pp7-8, Results and Discussion, YihU forms a dimer of intimate homodimer pairs; Figure 4A""}]"	"[{""id"": ""DOI:10.1021/acscatal.9b04427"", ""source_sha256"": ""30e34da151f2e8b37098047787c17689ff0161f7a20d11760c7cb4689288491d"", ""source_version"": ""2020 accepted author manuscript, not publisher version of record; SHA256 covers full 27-page institutional PDF including 2 cover pages"", ""title"": ""Dynamic Structural Changes Accompany the Production of Dihydroxypropanesulfonate by Sulfolactaldehyde Reductase"", ""url"": ""https://eprints.whiterose.ac.uk/id/eprint/156563/1/acscatal.9b04427.pdf""}, {""id"": ""MetaCyc:CPLX0-7794"", ""source_sha256"": ""fc5323760fb4485cd5e8ad7abf2710f218d66f61b309863cff1a0df70abc2a1b"", ""source_version"": ""MetaCyc 22.5 public mirror; complete native XML response retrieved 2026-10-11"", ""title"": ""3-sulfolactaldehyde reductase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7794""}, {""id"": ""MetaCyc:EG11847-MONOMER"", ""source_sha256"": ""8e639b7a5c4bb59a6fb113a147a0433064be6a1b1f4a7bfd90a3e5d9d0f08f11"", ""source_version"": ""MetaCyc 22.5 public mirror; complete native XML response retrieved 2026-10-11"", ""title"": ""3-sulfolactaldehyde reductase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:EG11847-MONOMER""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-025_32eadc5ee413	MetaCyc:CPLX0-7683	pathwaymech:catalyzes	RHEA:40440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7683|PMID:24463506|PMID:33791429|UniProtKB:P32140	The selected catabolic branch is SQ to SF. SR formation is real but belongs to adjacent side-reaction chemistry; no exclusive one-product or absolute alpha-anomer inactivity is asserted.	"[{""reference_id"": ""MetaCyc:CPLX0-7683"", ""source_assertion"": ""The native assembly catalyzes ENZRXN0-7820, linked to RXN-15296."", ""source_locator"": ""/ptools-xml/Protein/catalyzes/Enzymatic-Reaction[@frameid=\""ENZRXN0-7820\""]/reaction""}, {""reference_id"": ""UniProtKB:P32140"", ""source_assertion"": ""ECO:0000269; SQ isomerase activity and physiological left-to-right RHEA:40440 are annotated with direct evidence from PMID24463506 and PMID33791429."", ""source_locator"": ""/comments/0; /comments/1/reaction and physiologicalReactions""}, {""reference_id"": ""PMID:33791429"", ""source_assertion"": ""E. coli YihS interconverts SQ, SF and SR and strongly prefers beta-SQ. Slow alpha-SQ exchange may reflect mutarotation; low direct alpha activity was not excluded."", ""source_locator"": ""//sec[@id=\""sec2.1\""]/p[position() >= 1 and position() <= 4]; Figure 2a-b""}, {""reference_id"": ""PMID:24463506"", ""source_assertion"": ""Purified recombinant b3880 converted SQ into SF in the sequential reconstitution."", ""source_locator"": ""Printed pp115-116, Figure 3a-b; Methods, Heterologous expression and purification""}]"	"[{""id"": ""MetaCyc:CPLX0-7683"", ""source_sha256"": ""bdeeb46a5fd6bde252e6057c0c9ffd780bb4d737e1050521c46800de83b62961"", ""source_version"": ""MetaCyc 22.5 public mirror; complete native XML response retrieved 2026-10-11"", ""title"": ""sulfoquinovose isomerase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7683""}, {""id"": ""PMID:24463506"", ""source_sha256"": ""e3c80fff89a548b26f8de5578e100c17c995e098243256d5f3d96058809aa61d"", ""source_version"": ""Original 2014 Nature article with Methods and Extended Data; SHA256 covers complete 15-page institutional PDF"", ""title"": ""Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle."", ""url"": ""https://kops.uni-konstanz.de/bitstream/123456789/26077/2/Denger_260772.pdf""}, {""id"": ""PMID:33791429"", ""source_sha256"": ""b94d347820a23930dbde3ada5f6f2805d56a42e6ae3e3d580611ab93e5a53c05"", ""source_version"": ""Original 2021 full-text JATS XML; complete response retrieved 2026-10-11"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8006165/fullTextXML""}, {""id"": ""UniProtKB:P32140"", ""source_sha256"": ""20ad003895196c86a8af23d588466a45cbc0e86056bbc89a976c69e555ae0407"", ""source_version"": ""UniProt 2026_03 (02-September-2026); complete original entry JSON retrieved 2026-10-11"", ""title"": ""Sulfoquinovose isomerase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P32140.json""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-026_b78ac5a798c7	UniProtKB:P32143	pathwaymech:enables	RHEA:40444	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/acscentsci.0c01285.s001|PMID:24463506|PMID:33791429|UniProtKB:P32143	Functional gene-product support, not monomer sufficiency. No verified external assembly instance is substituted for the source-supported dimeric enzyme.	"[{""reference_id"": ""UniProtKB:P32143"", ""source_assertion"": ""ECO:0000269; The entry assigns SF kinase activity and RHEA:40444 to YihV with direct 2014/2021 evidence."", ""source_locator"": ""/comments/0; /comments/1/reaction and physiologicalReactions""}, {""reference_id"": ""PMID:24463506"", ""source_assertion"": ""Adding purified recombinant b3883 and ATP after b3880 produced SFP and ADP; phosphatase treatment converted SFP back to SF."", ""source_locator"": ""Printed p115; Figure 3b-c; Methods, Heterologous expression and purification""}, {""reference_id"": ""PMID:33791429"", ""source_assertion"": ""E. coli YihV forms a dimeric structure with intersubunit active-site contacts. SEC-MALS showed more than 60% dimer and a 13% tetramer subpopulation."", ""source_locator"": ""//sec[@id=\""sec2.3\""]/p[3]; Figure 4b-f""}, {""reference_id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_assertion"": ""Figure S9 explicitly identifies the solution assembly experiment as EcYihV; Figure S9B reports dimer, minor tetramer and higher aggregates."", ""source_locator"": ""Figure S9 caption, printed S10; Section 2, S29; EcYihV sequence, S30""}]"	"[{""id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_sha256"": ""a4d4f57a30c7ac7cff3a62d644e074913ebda0390a5e0a91f91e5e97f560ffbc"", ""source_version"": ""Original publisher-deposited supplement, linked by Figshare article 14096259 to DOI 10.1021/acscentsci.0c01285; complete PDF"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis: Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/26577379""}, {""id"": ""PMID:24463506"", ""source_sha256"": ""e3c80fff89a548b26f8de5578e100c17c995e098243256d5f3d96058809aa61d"", ""source_version"": ""Original 2014 Nature article with Methods and Extended Data; SHA256 covers complete 15-page institutional PDF"", ""title"": ""Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle."", ""url"": ""https://kops.uni-konstanz.de/bitstream/123456789/26077/2/Denger_260772.pdf""}, {""id"": ""PMID:33791429"", ""source_sha256"": ""b94d347820a23930dbde3ada5f6f2805d56a42e6ae3e3d580611ab93e5a53c05"", ""source_version"": ""Original 2021 full-text JATS XML; complete response retrieved 2026-10-11"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8006165/fullTextXML""}, {""id"": ""UniProtKB:P32143"", ""source_sha256"": ""43e1a70a99162988cb01c8e6dcc365d6c263fbabfa8312c10622d7ed989f0600"", ""source_version"": ""UniProt 2026_03 (02-September-2026); complete original entry JSON retrieved 2026-10-11"", ""title"": ""Sulfofructose kinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P32143.json""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-027_b03a7dc2dede	UniProtKB:P32141	pathwaymech:enables	RHEA:40516	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/acscatal.9b04427|DOI:10.1021/acscentsci.0c01285.s001|MetaCyc:EG11846-MONOMER|PMID:24463506|PMID:33791429|UniProtKB:P32141	E. coli pathway function is supported by the 2014 coupled assay and genetics despite the later preparation-specific negative assay. No Salmonella kinetic constants, solution stoichiometry or Schiff-base residue experiment is transferred as direct E. coli evidence. Current (2S) chemistry supersedes older native protein-comment (2R) wording.	"[{""reference_id"": ""UniProtKB:P32141"", ""source_assertion"": ""ECO:0000269; The entry assigns SFP cleavage to (2S)-SLA and DHAP, with direct PMID24463506 and HAMAP MF_01912 evidence."", ""source_locator"": ""/comments/0; /comments/1/reaction and physiologicalReactions""}, {""reference_id"": ""PMID:24463506"", ""source_assertion"": ""Adding recombinant b3881 to the coupled b3880/b3883 system generated SLA and DHAP; subsequent NADH/YihU addition drove conversion further."", ""source_locator"": ""Printed p116; Figure 3c-e; Methods, Heterologous expression and purification""}, {""reference_id"": ""PMID:33791429"", ""source_assertion"": ""The 2021 study detected no activity with its E. coli YihT preparation under tested conditions, then used Salmonella YihT for positive direct kinetics."", ""source_locator"": ""//sec[@id=\""sec2.4\""]/p[1]""}, {""reference_id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_assertion"": ""Figure S19 solution tetramer data are for SeYihT. Figure S20B displays crystallographic tetramers of EcYihT and SeYihT; this does not establish an E. coli solution tetramer experimentally."", ""source_locator"": ""Figure S19 caption, S19; Figure S20B caption, S20; EcYihT and SeYihT sequences, S30""}, {""reference_id"": ""MetaCyc:EG11846-MONOMER"", ""source_assertion"": ""The old protein comment names (2R)-SLA. This legacy wording is not used as evidence for the selected absolute stereochemistry."", ""source_locator"": ""/ptools-xml/Protein/comment""}, {""reference_id"": ""DOI:10.1021/acscatal.9b04427"", ""source_assertion"": ""Figure 1A explicitly depicts the sulfo-EMP aldehyde as S-SLA and its reduction product as S-DHPS."", ""source_locator"": ""Accepted manuscript Figure 1A, printed p18 (PDF page20)""}]"	"[{""id"": ""DOI:10.1021/acscatal.9b04427"", ""source_sha256"": ""30e34da151f2e8b37098047787c17689ff0161f7a20d11760c7cb4689288491d"", ""source_version"": ""2020 accepted author manuscript, not publisher version of record; SHA256 covers full 27-page institutional PDF including 2 cover pages"", ""title"": ""Dynamic Structural Changes Accompany the Production of Dihydroxypropanesulfonate by Sulfolactaldehyde Reductase"", ""url"": ""https://eprints.whiterose.ac.uk/id/eprint/156563/1/acscatal.9b04427.pdf""}, {""id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_sha256"": ""a4d4f57a30c7ac7cff3a62d644e074913ebda0390a5e0a91f91e5e97f560ffbc"", ""source_version"": ""Original publisher-deposited supplement, linked by Figshare article 14096259 to DOI 10.1021/acscentsci.0c01285; complete PDF"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis: Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/26577379""}, {""id"": ""MetaCyc:EG11846-MONOMER"", ""source_sha256"": ""1847d995e87087834275fbbc543142164ca25d6ccf3e7bd315047c3e27be5921"", ""source_version"": ""MetaCyc 22.5 public mirror; complete native XML response retrieved 2026-10-11"", ""title"": ""6-deoxy-6-sulfofructose-1-phosphate aldolase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:EG11846-MONOMER""}, {""id"": ""PMID:24463506"", ""source_sha256"": ""e3c80fff89a548b26f8de5578e100c17c995e098243256d5f3d96058809aa61d"", ""source_version"": ""Original 2014 Nature article with Methods and Extended Data; SHA256 covers complete 15-page institutional PDF"", ""title"": ""Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle."", ""url"": ""https://kops.uni-konstanz.de/bitstream/123456789/26077/2/Denger_260772.pdf""}, {""id"": ""PMID:33791429"", ""source_sha256"": ""b94d347820a23930dbde3ada5f6f2805d56a42e6ae3e3d580611ab93e5a53c05"", ""source_version"": ""Original 2021 full-text JATS XML; complete response retrieved 2026-10-11"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8006165/fullTextXML""}, {""id"": ""UniProtKB:P32141"", ""source_sha256"": ""877627100957281e8898a3aacfafab731d4bce0d1de8bcc1800f718d4a465b8b"", ""source_version"": ""UniProt 2026_03 (02-September-2026); complete original entry JSON retrieved 2026-10-11"", ""title"": ""Sulfofructosephosphate aldolase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P32141.json""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-028_0f3cc1d9ef75	MetaCyc:CPLX0-7794	pathwaymech:catalyzes	RHEA:40513	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/acscatal.9b04427|MetaCyc:CPLX0-7794|PMID:24463506|UniProtKB:P0A9V8	The selected reductive flux is right-to-left relative to the Rhea master. NADH is a consumed cosubstrate, not a permanently bound prosthetic group; old relative D/L naming is not used to infer a different absolute stereoisomer.	"[{""reference_id"": ""MetaCyc:CPLX0-7794"", ""source_assertion"": ""The native tetramer catalyzes ENZRXN0-7824 linked to RXN-15299."", ""source_locator"": ""/ptools-xml/Protein/catalyzes/Enzymatic-Reaction[@frameid=\""ENZRXN0-7824\""]/reaction""}, {""reference_id"": ""UniProtKB:P0A9V8"", ""source_assertion"": ""ECO:0000269; The entry annotates (2S)-SLA reduction by NADH, physiological right-to-left RHEA:40513, with direct PMID24463506 and DOI10.1021/acscatal.9b04427 evidence."", ""source_locator"": ""/comments/0; /comments/1/reaction and physiologicalReactions""}, {""reference_id"": ""PMID:24463506"", ""source_assertion"": ""SLA reductase activity was enriched from SQ-grown MG1655 and reconstituted with recombinant b3882; NADH drove SLA to DHPS. In the reverse assay NADP did not replace NAD."", ""source_locator"": ""Printed pp115-116; Figure 3d-e; Methods, Enzyme assays and Heterologous expression and purification""}, {""reference_id"": ""DOI:10.1021/acscatal.9b04427"", ""source_assertion"": ""The E. coli YihU ternary structure models S-DHPS; Figure 1A labels S-SLA to S-DHPS. Kinetics used racemic SLA with an assumed active half, described as D-SLA in the text."", ""source_locator"": ""Accepted manuscript printed pp6,10-11 and18; Figure 1A and Figure 6A-C""}]"	"[{""id"": ""DOI:10.1021/acscatal.9b04427"", ""source_sha256"": ""30e34da151f2e8b37098047787c17689ff0161f7a20d11760c7cb4689288491d"", ""source_version"": ""2020 accepted author manuscript, not publisher version of record; SHA256 covers full 27-page institutional PDF including 2 cover pages"", ""title"": ""Dynamic Structural Changes Accompany the Production of Dihydroxypropanesulfonate by Sulfolactaldehyde Reductase"", ""url"": ""https://eprints.whiterose.ac.uk/id/eprint/156563/1/acscatal.9b04427.pdf""}, {""id"": ""MetaCyc:CPLX0-7794"", ""source_sha256"": ""fc5323760fb4485cd5e8ad7abf2710f218d66f61b309863cff1a0df70abc2a1b"", ""source_version"": ""MetaCyc 22.5 public mirror; complete native XML response retrieved 2026-10-11"", ""title"": ""3-sulfolactaldehyde reductase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7794""}, {""id"": ""PMID:24463506"", ""source_sha256"": ""e3c80fff89a548b26f8de5578e100c17c995e098243256d5f3d96058809aa61d"", ""source_version"": ""Original 2014 Nature article with Methods and Extended Data; SHA256 covers complete 15-page institutional PDF"", ""title"": ""Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle."", ""url"": ""https://kops.uni-konstanz.de/bitstream/123456789/26077/2/Denger_260772.pdf""}, {""id"": ""UniProtKB:P0A9V8"", ""source_sha256"": ""f1f73b2da94788f660d7d5dac2ec30045d4c58ebe5050d9b56381d4c3e4d9f5b"", ""source_version"": ""UniProt 2026_03 (02-September-2026); complete original entry JSON retrieved 2026-10-11"", ""title"": ""3-sulfolactaldehyde reductase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A9V8.json""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-029_95f8476be303	UniProtKB:P32143	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/acscentsci.0c01285.s001|PMID:33791429	Nucleotide-associated Mg binding and assay support are retained; no metal-removal/rescue test, exclusivity among divalent ions or fixed per-enzyme stoichiometry is claimed.	"[{""reference_id"": ""PMID:33791429"", ""source_assertion"": ""EcYihV structures contain hydrated Mg with AMPPNP and Mg coordinated to ADP in the SF complex; kinetic assays used MgCl2."", ""source_locator"": ""//sec[@id=\""sec2.3\""]/p[position()=1 or position()=4 or position()=6]; Figure 4b-f""}, {""reference_id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_assertion"": ""EcYihV kinetic assays contained 5 mM MgCl2 with ATP."", ""source_locator"": ""Section SF kinase (YihV) kinetics, printed S33-S34""}]"	"[{""id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_sha256"": ""a4d4f57a30c7ac7cff3a62d644e074913ebda0390a5e0a91f91e5e97f560ffbc"", ""source_version"": ""Original publisher-deposited supplement, linked by Figshare article 14096259 to DOI 10.1021/acscentsci.0c01285; complete PDF"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis: Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/26577379""}, {""id"": ""PMID:33791429"", ""source_sha256"": ""b94d347820a23930dbde3ada5f6f2805d56a42e6ae3e3d580611ab93e5a53c05"", ""source_version"": ""Original 2021 full-text JATS XML; complete response retrieved 2026-10-11"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8006165/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-030_67254665d0d4	UniProtKB:P32144	pathwaymech:inhibits	MetaCyc:PWY-7446	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:30372406|UniProtKB:P32144	Transcriptional repression of pathway-enzyme genes, not direct inhibition of the catalytic reactions.	"[{""reference_id"": ""PMID:30372406"", ""source_assertion"": ""Genomic SELEX, gel shifts and in vivo reporters support CsqR repression of yihUTS, yihV and csqR transcription units in E. coli K-12."", ""source_locator"": ""/resultList/result[id=\""30372406\""]/abstractText""}, {""reference_id"": ""UniProtKB:P32144"", ""source_assertion"": ""ECO:0000269; CsqR represses yihUTS, yihV and its own gene and binds their regulatory DNA."", ""source_locator"": ""/comments/0""}]"	"[{""id"": ""PMID:30372406"", ""source_sha256"": ""aba137ecfa831c28bbe34b3ecdfaba2bd7421b468a6726ee3ed7bcd2c1c17e84"", ""source_version"": ""Primary abstract inspected through Europe PMC; SHA256 covers the complete single-PMID API JSON response, /resultList/result/0"", ""title"": ""Regulatory role of CsqR (YihW) in transcription of the genes for catabolism of the anionic sugar sulfoquinovose (SQ) in Escherichia coli K-12."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/30372406/""}, {""id"": ""UniProtKB:P32144"", ""source_sha256"": ""7ad472572ed9ad78e8554b55add376e4e4e97a6bba1f90b5b069878556f480e5"", ""source_version"": ""UniProt 2026_03 (02-September-2026); complete original entry JSON retrieved 2026-10-11"", ""title"": ""HTH-type transcriptional repressor CsqR"", ""url"": ""https://rest.uniprot.org/uniprotkb/P32144.json""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-031_ce6ae65781dd	CHEBI:77132	pathwaymech:inhibits	UniProtKB:P32144	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33791429	In vitro derepression context; no universal cellular threshold or unique anomer specificity is assigned.	"[{""reference_id"": ""PMID:33791429"", ""source_assertion"": ""SQ disrupts E. coli CsqR-DNA binding in gel-shift and AFM experiments; these assays do not resolve the SQ anomer."", ""source_locator"": ""//sec[@id=\""sec2.2\""]/p[position() >= 1 and position() <= 3]""}]"	"[{""id"": ""PMID:33791429"", ""source_sha256"": ""b94d347820a23930dbde3ada5f6f2805d56a42e6ae3e3d580611ab93e5a53c05"", ""source_version"": ""Original 2021 full-text JATS XML; complete response retrieved 2026-10-11"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8006165/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-032_f560cb2c4ab6	CHEBI:190019	pathwaymech:inhibits	UniProtKB:P32144	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33791429	In vitro derepression context; no universal cellular threshold or unique anomer specificity is assigned.	"[{""reference_id"": ""PMID:33791429"", ""source_assertion"": ""SR relieves CsqR-DNA complexes in gel-shift and AFM experiments, less strongly than SQ; SR did not stabilize the isolated effector-binding domain at 10 mM."", ""source_locator"": ""//sec[@id=\""sec2.2\""]/p[position() >= 1 and position() <= 3]""}]"	"[{""id"": ""PMID:33791429"", ""source_sha256"": ""b94d347820a23930dbde3ada5f6f2805d56a42e6ae3e3d580611ab93e5a53c05"", ""source_version"": ""Original 2021 full-text JATS XML; complete response retrieved 2026-10-11"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8006165/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-033_2a0469e6efbd	CHEBI:456216	pathwaymech:inhibits	UniProtKB:P32143	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/acscentsci.0c01285.s001|PMID:33791429	Regulatory effects are conditional. Anomer-unspecified SQ/FBP and stereounspecified SLA preserve the assay scope; they are not additional core-reaction intermediates.	"[{""reference_id"": ""PMID:33791429"", ""source_assertion"": ""The study reports ADP inhibition of EcYihV under its metabolite-addition assay conditions."", ""source_locator"": ""//sec[@id=\""sec2.3\""]/p[1]; Table 1 and Figure 4a""}, {""reference_id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_assertion"": ""Added metabolites were tested at 10 mM in ATP/Mg assays at pH7.5 and 30 degrees C. These are conditional enzyme experiments, not measured intracellular concentrations."", ""source_locator"": ""SF kinase (YihV) kinetics, printed S33-S34""}]"	"[{""id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_sha256"": ""a4d4f57a30c7ac7cff3a62d644e074913ebda0390a5e0a91f91e5e97f560ffbc"", ""source_version"": ""Original publisher-deposited supplement, linked by Figshare article 14096259 to DOI 10.1021/acscentsci.0c01285; complete PDF"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis: Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/26577379""}, {""id"": ""PMID:33791429"", ""source_sha256"": ""b94d347820a23930dbde3ada5f6f2805d56a42e6ae3e3d580611ab93e5a53c05"", ""source_version"": ""Original 2021 full-text JATS XML; complete response retrieved 2026-10-11"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8006165/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-034_f22e267330c7	CHEBI:77132	pathwaymech:activates	UniProtKB:P32143	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/acscentsci.0c01285.s001|PMID:33791429	Regulatory effects are conditional. Anomer-unspecified SQ/FBP and stereounspecified SLA preserve the assay scope; they are not additional core-reaction intermediates.	"[{""reference_id"": ""PMID:33791429"", ""source_assertion"": ""The study reports SQ activation of EcYihV under its metabolite-addition assay conditions."", ""source_locator"": ""//sec[@id=\""sec2.3\""]/p[1]; Table 1 and Figure 4a""}, {""reference_id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_assertion"": ""Added metabolites were tested at 10 mM in ATP/Mg assays at pH7.5 and 30 degrees C. These are conditional enzyme experiments, not measured intracellular concentrations."", ""source_locator"": ""SF kinase (YihV) kinetics, printed S33-S34""}]"	"[{""id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_sha256"": ""a4d4f57a30c7ac7cff3a62d644e074913ebda0390a5e0a91f91e5e97f560ffbc"", ""source_version"": ""Original publisher-deposited supplement, linked by Figshare article 14096259 to DOI 10.1021/acscentsci.0c01285; complete PDF"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis: Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/26577379""}, {""id"": ""PMID:33791429"", ""source_sha256"": ""b94d347820a23930dbde3ada5f6f2805d56a42e6ae3e3d580611ab93e5a53c05"", ""source_version"": ""Original 2021 full-text JATS XML; complete response retrieved 2026-10-11"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8006165/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-035_8a280715f961	CHEBI:77135	pathwaymech:activates	UniProtKB:P32143	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/acscentsci.0c01285.s001|PMID:33791429	Regulatory effects are conditional. Anomer-unspecified SQ/FBP and stereounspecified SLA preserve the assay scope; they are not additional core-reaction intermediates.	"[{""reference_id"": ""PMID:33791429"", ""source_assertion"": ""The study reports SLA activation of EcYihV under its metabolite-addition assay conditions."", ""source_locator"": ""//sec[@id=\""sec2.3\""]/p[1]; Table 1 and Figure 4a""}, {""reference_id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_assertion"": ""Added metabolites were tested at 10 mM in ATP/Mg assays at pH7.5 and 30 degrees C. These are conditional enzyme experiments, not measured intracellular concentrations."", ""source_locator"": ""SF kinase (YihV) kinetics, printed S33-S34""}]"	"[{""id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_sha256"": ""a4d4f57a30c7ac7cff3a62d644e074913ebda0390a5e0a91f91e5e97f560ffbc"", ""source_version"": ""Original publisher-deposited supplement, linked by Figshare article 14096259 to DOI 10.1021/acscentsci.0c01285; complete PDF"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis: Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/26577379""}, {""id"": ""PMID:33791429"", ""source_sha256"": ""b94d347820a23930dbde3ada5f6f2805d56a42e6ae3e3d580611ab93e5a53c05"", ""source_version"": ""Original 2021 full-text JATS XML; complete response retrieved 2026-10-11"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8006165/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-036_0331be2d1c6a	CHEBI:57642	pathwaymech:activates	UniProtKB:P32143	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/acscentsci.0c01285.s001|PMID:33791429	Regulatory effects are conditional. Anomer-unspecified SQ/FBP and stereounspecified SLA preserve the assay scope; they are not additional core-reaction intermediates.	"[{""reference_id"": ""PMID:33791429"", ""source_assertion"": ""The study reports DHAP activation of EcYihV under its metabolite-addition assay conditions."", ""source_locator"": ""//sec[@id=\""sec2.3\""]/p[1]; Table 1 and Figure 4a""}, {""reference_id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_assertion"": ""Added metabolites were tested at 10 mM in ATP/Mg assays at pH7.5 and 30 degrees C. These are conditional enzyme experiments, not measured intracellular concentrations."", ""source_locator"": ""SF kinase (YihV) kinetics, printed S33-S34""}]"	"[{""id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_sha256"": ""a4d4f57a30c7ac7cff3a62d644e074913ebda0390a5e0a91f91e5e97f560ffbc"", ""source_version"": ""Original publisher-deposited supplement, linked by Figshare article 14096259 to DOI 10.1021/acscentsci.0c01285; complete PDF"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis: Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/26577379""}, {""id"": ""PMID:33791429"", ""source_sha256"": ""b94d347820a23930dbde3ada5f6f2805d56a42e6ae3e3d580611ab93e5a53c05"", ""source_version"": ""Original 2021 full-text JATS XML; complete response retrieved 2026-10-11"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8006165/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-037_1b9a6d315a7f	CHEBI:57579	pathwaymech:activates	UniProtKB:P32143	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/acscentsci.0c01285.s001|PMID:33791429	Regulatory effects are conditional. Anomer-unspecified SQ/FBP and stereounspecified SLA preserve the assay scope; they are not additional core-reaction intermediates.	"[{""reference_id"": ""PMID:33791429"", ""source_assertion"": ""The study reports F6P activation of EcYihV under its metabolite-addition assay conditions."", ""source_locator"": ""//sec[@id=\""sec2.3\""]/p[1]; Table 1 and Figure 4a""}, {""reference_id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_assertion"": ""Added metabolites were tested at 10 mM in ATP/Mg assays at pH7.5 and 30 degrees C. These are conditional enzyme experiments, not measured intracellular concentrations."", ""source_locator"": ""SF kinase (YihV) kinetics, printed S33-S34""}]"	"[{""id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_sha256"": ""a4d4f57a30c7ac7cff3a62d644e074913ebda0390a5e0a91f91e5e97f560ffbc"", ""source_version"": ""Original publisher-deposited supplement, linked by Figshare article 14096259 to DOI 10.1021/acscentsci.0c01285; complete PDF"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis: Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/26577379""}, {""id"": ""PMID:33791429"", ""source_sha256"": ""b94d347820a23930dbde3ada5f6f2805d56a42e6ae3e3d580611ab93e5a53c05"", ""source_version"": ""Original 2021 full-text JATS XML; complete response retrieved 2026-10-11"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8006165/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-038_f48efb4f91ad	CHEBI:49299	pathwaymech:activates	UniProtKB:P32143	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/acscentsci.0c01285.s001|PMID:33791429	Regulatory effects are conditional. Anomer-unspecified SQ/FBP and stereounspecified SLA preserve the assay scope; they are not additional core-reaction intermediates.	"[{""reference_id"": ""PMID:33791429"", ""source_assertion"": ""The study reports FBP activation of EcYihV under its metabolite-addition assay conditions."", ""source_locator"": ""//sec[@id=\""sec2.3\""]/p[1]; Table 1 and Figure 4a""}, {""reference_id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_assertion"": ""Added metabolites were tested at 10 mM in ATP/Mg assays at pH7.5 and 30 degrees C. These are conditional enzyme experiments, not measured intracellular concentrations."", ""source_locator"": ""SF kinase (YihV) kinetics, printed S33-S34""}]"	"[{""id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_sha256"": ""a4d4f57a30c7ac7cff3a62d644e074913ebda0390a5e0a91f91e5e97f560ffbc"", ""source_version"": ""Original publisher-deposited supplement, linked by Figshare article 14096259 to DOI 10.1021/acscentsci.0c01285; complete PDF"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis: Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/26577379""}, {""id"": ""PMID:33791429"", ""source_sha256"": ""b94d347820a23930dbde3ada5f6f2805d56a42e6ae3e3d580611ab93e5a53c05"", ""source_version"": ""Original 2021 full-text JATS XML; complete response retrieved 2026-10-11"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8006165/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-039_14fa26401756	CHEBI:58702	pathwaymech:activates	UniProtKB:P32143	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/acscentsci.0c01285.s001|PMID:33791429	Regulatory effects are conditional. Anomer-unspecified SQ/FBP and stereounspecified SLA preserve the assay scope; they are not additional core-reaction intermediates.	"[{""reference_id"": ""PMID:33791429"", ""source_assertion"": ""The study reports PEP activation of EcYihV under its metabolite-addition assay conditions."", ""source_locator"": ""//sec[@id=\""sec2.3\""]/p[1]; Table 1 and Figure 4a""}, {""reference_id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_assertion"": ""Added metabolites were tested at 10 mM in ATP/Mg assays at pH7.5 and 30 degrees C. These are conditional enzyme experiments, not measured intracellular concentrations."", ""source_locator"": ""SF kinase (YihV) kinetics, printed S33-S34""}]"	"[{""id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_sha256"": ""a4d4f57a30c7ac7cff3a62d644e074913ebda0390a5e0a91f91e5e97f560ffbc"", ""source_version"": ""Original publisher-deposited supplement, linked by Figshare article 14096259 to DOI 10.1021/acscentsci.0c01285; complete PDF"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis: Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/26577379""}, {""id"": ""PMID:33791429"", ""source_sha256"": ""b94d347820a23930dbde3ada5f6f2805d56a42e6ae3e3d580611ab93e5a53c05"", ""source_version"": ""Original 2021 full-text JATS XML; complete response retrieved 2026-10-11"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8006165/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-040_95d7c0df6582	CHEBI:16947	pathwaymech:activates	UniProtKB:P32143	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.1021/acscentsci.0c01285.s001|PMID:33791429	Regulatory effects are conditional. Anomer-unspecified SQ/FBP and stereounspecified SLA preserve the assay scope; they are not additional core-reaction intermediates.	"[{""reference_id"": ""PMID:33791429"", ""source_assertion"": ""The study reports citrate activation of EcYihV under its metabolite-addition assay conditions."", ""source_locator"": ""//sec[@id=\""sec2.3\""]/p[1]; Table 1 and Figure 4a""}, {""reference_id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_assertion"": ""Added metabolites were tested at 10 mM in ATP/Mg assays at pH7.5 and 30 degrees C. These are conditional enzyme experiments, not measured intracellular concentrations."", ""source_locator"": ""SF kinase (YihV) kinetics, printed S33-S34""}]"	"[{""id"": ""DOI:10.1021/acscentsci.0c01285.s001"", ""source_sha256"": ""a4d4f57a30c7ac7cff3a62d644e074913ebda0390a5e0a91f91e5e97f560ffbc"", ""source_version"": ""Original publisher-deposited supplement, linked by Figshare article 14096259 to DOI 10.1021/acscentsci.0c01285; complete PDF"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis: Supporting Information"", ""url"": ""https://ndownloader.figshare.com/files/26577379""}, {""id"": ""PMID:33791429"", ""source_sha256"": ""b94d347820a23930dbde3ada5f6f2805d56a42e6ae3e3d580611ab93e5a53c05"", ""source_version"": ""Original 2021 full-text JATS XML; complete response retrieved 2026-10-11"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8006165/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-7446_sulfoquinovose-edge-041_1461aa090f77	CHEBI:77133	pathwaymech:inhibits	UniProtKB:P32143	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33791429	A substrate can also inhibit at elevated concentration; this edge is explicitly conditional and does not negate SF consumption by the kinase reaction.	"[{""reference_id"": ""PMID:33791429"", ""source_assertion"": ""SF substrate inhibition of EcYihV depended on ATP concentration: estimated Ki about 8 mM at 1 mM ATP and 0.3 mM at 0.1 mM ATP."", ""source_locator"": ""//sec[@id=\""sec2.3\""]/p[1]; Table 1""}]"	"[{""id"": ""PMID:33791429"", ""source_sha256"": ""b94d347820a23930dbde3ada5f6f2805d56a42e6ae3e3d580611ab93e5a53c05"", ""source_version"": ""Original 2021 full-text JATS XML; complete response retrieved 2026-10-11"", ""title"": ""Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8006165/fullTextXML""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-001_224974dbfefd	CHEBI:77132	pathwaymech:consumes	RHEA:47897	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47897		"[{""reference_id"": ""RHEA:47897"", ""source_assertion"": ""RHEA:47897 assigns CHEBI:77132 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47897\""]/rh:substrates; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47896_L\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47896_compound_9101\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_9101)""}]"	"[{""id"": ""RHEA:47897"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-sulfo-D-quinovose + NAD(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + NADH + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47897""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-002_d03e878d1d68	CHEBI:57540	pathwaymech:consumes	RHEA:47897	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47897		"[{""reference_id"": ""RHEA:47897"", ""source_assertion"": ""RHEA:47897 assigns CHEBI:57540 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47897\""]/rh:substrates; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47896_L\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47896_compound_3484\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3484)""}]"	"[{""id"": ""RHEA:47897"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-sulfo-D-quinovose + NAD(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + NADH + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47897""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-003_4ee82d03569b	RHEA:47897	pathwaymech:produces	CHEBI:88091	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47897		"[{""reference_id"": ""RHEA:47897"", ""source_assertion"": ""RHEA:47897 assigns CHEBI:88091 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47897\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47896_R\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47896_compound_11949\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_11949)""}]"	"[{""id"": ""RHEA:47897"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-sulfo-D-quinovose + NAD(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + NADH + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47897""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-004_9d8a9404542c	RHEA:47897	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47897		"[{""reference_id"": ""RHEA:47897"", ""source_assertion"": ""RHEA:47897 assigns CHEBI:57945 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47897\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47896_R\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47896_compound_1650\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_1650)""}]"	"[{""id"": ""RHEA:47897"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-sulfo-D-quinovose + NAD(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + NADH + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47897""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-005_fec078e2276e	RHEA:47897	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47897		"[{""reference_id"": ""RHEA:47897"", ""source_assertion"": ""RHEA:47897 assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47897\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47896_R\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47896_compound_3249\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3249)""}]"	"[{""id"": ""RHEA:47897"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-sulfo-D-quinovose + NAD(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + NADH + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47897""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-006_3fc58a209d62	CHEBI:88091	pathwaymech:consumes	RHEA:47909	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47909		"[{""reference_id"": ""RHEA:47909"", ""source_assertion"": ""RHEA:47909 assigns CHEBI:88091 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47909\""]/rh:substrates; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47908_L\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47908_compound_11949\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_11949)""}]"	"[{""id"": ""RHEA:47909"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O => 6-deoxy-6-sulfo-D-gluconate + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47909""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-007_0ca49ae531a8	CHEBI:15377	pathwaymech:consumes	RHEA:47909	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47909		"[{""reference_id"": ""RHEA:47909"", ""source_assertion"": ""RHEA:47909 assigns CHEBI:15377 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47909\""]/rh:substrates; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47908_L\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47908_compound_1283\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_1283)""}]"	"[{""id"": ""RHEA:47909"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O => 6-deoxy-6-sulfo-D-gluconate + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47909""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-008_530939bfb03d	RHEA:47909	pathwaymech:produces	CHEBI:88093	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47909		"[{""reference_id"": ""RHEA:47909"", ""source_assertion"": ""RHEA:47909 assigns CHEBI:88093 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47909\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47908_R\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47908_compound_11950\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_11950)""}]"	"[{""id"": ""RHEA:47909"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O => 6-deoxy-6-sulfo-D-gluconate + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47909""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-009_c45ccb585c3d	RHEA:47909	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47909		"[{""reference_id"": ""RHEA:47909"", ""source_assertion"": ""RHEA:47909 assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47909\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47908_R\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47908_compound_3249\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3249)""}]"	"[{""id"": ""RHEA:47909"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O => 6-deoxy-6-sulfo-D-gluconate + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47909""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-010_b958eed76f0f	CHEBI:88093	pathwaymech:consumes	RHEA:47913	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47913		"[{""reference_id"": ""RHEA:47913"", ""source_assertion"": ""RHEA:47913 assigns CHEBI:88093 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47913\""]/rh:substrates; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47912_L\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47912_compound_11950\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_11950)""}]"	"[{""id"": ""RHEA:47913"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-deoxy-6-sulfo-D-gluconate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O"", ""url"": ""https://www.rhea-db.org/rhea/47913""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-011_1e39aee6abd7	RHEA:47913	pathwaymech:produces	CHEBI:88094	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47913		"[{""reference_id"": ""RHEA:47913"", ""source_assertion"": ""RHEA:47913 assigns CHEBI:88094 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47913\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47912_R\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47912_compound_11951\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_11951)""}]"	"[{""id"": ""RHEA:47913"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-deoxy-6-sulfo-D-gluconate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O"", ""url"": ""https://www.rhea-db.org/rhea/47913""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-012_ee107e001b5a	RHEA:47913	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47913		"[{""reference_id"": ""RHEA:47913"", ""source_assertion"": ""RHEA:47913 assigns CHEBI:15377 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47913\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47912_R\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47912_compound_1283\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_1283)""}]"	"[{""id"": ""RHEA:47913"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-deoxy-6-sulfo-D-gluconate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O"", ""url"": ""https://www.rhea-db.org/rhea/47913""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-013_2b46d0b37f2a	CHEBI:88094	pathwaymech:consumes	RHEA:47925	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47925		"[{""reference_id"": ""RHEA:47925"", ""source_assertion"": ""RHEA:47925 assigns CHEBI:88094 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47925\""]/rh:substrates; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47924_L\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47924_compound_11951\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_11951)""}]"	"[{""id"": ""RHEA:47925"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate => (2S)-3-sulfolactaldehyde + pyruvate"", ""url"": ""https://www.rhea-db.org/rhea/47925""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-014_d781650a11c8	RHEA:47925	pathwaymech:produces	CHEBI:90109	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47925		"[{""reference_id"": ""RHEA:47925"", ""source_assertion"": ""RHEA:47925 assigns CHEBI:90109 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47925\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47924_R\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47924_compound_12045\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_12045)""}]"	"[{""id"": ""RHEA:47925"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate => (2S)-3-sulfolactaldehyde + pyruvate"", ""url"": ""https://www.rhea-db.org/rhea/47925""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-015_66f109a593e9	RHEA:47925	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47925		"[{""reference_id"": ""RHEA:47925"", ""source_assertion"": ""RHEA:47925 assigns CHEBI:15361 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47925\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47924_R\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47924_compound_3719\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3719)""}]"	"[{""id"": ""RHEA:47925"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate => (2S)-3-sulfolactaldehyde + pyruvate"", ""url"": ""https://www.rhea-db.org/rhea/47925""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-016_0623b2d450ec	CHEBI:90109	pathwaymech:consumes	RHEA:47929	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47929		"[{""reference_id"": ""RHEA:47929"", ""source_assertion"": ""RHEA:47929 assigns CHEBI:90109 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47929\""]/rh:substrates; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47928_L\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47928_compound_12045\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_12045)""}]"	"[{""id"": ""RHEA:47929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""(2S)-3-sulfolactaldehyde + NADP(+) + H2O => (2S)-3-sulfolactate + NADPH + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47929""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-017_b3c42210a349	CHEBI:58349	pathwaymech:consumes	RHEA:47929	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47929		"[{""reference_id"": ""RHEA:47929"", ""source_assertion"": ""RHEA:47929 assigns CHEBI:58349 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47929\""]/rh:substrates; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47928_L\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47928_compound_5188\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_5188)""}]"	"[{""id"": ""RHEA:47929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""(2S)-3-sulfolactaldehyde + NADP(+) + H2O => (2S)-3-sulfolactate + NADPH + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47929""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-018_e5c5aab888dd	CHEBI:15377	pathwaymech:consumes	RHEA:47929	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47929		"[{""reference_id"": ""RHEA:47929"", ""source_assertion"": ""RHEA:47929 assigns CHEBI:15377 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47929\""]/rh:substrates; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47928_L\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47928_compound_1283\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_1283)""}]"	"[{""id"": ""RHEA:47929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""(2S)-3-sulfolactaldehyde + NADP(+) + H2O => (2S)-3-sulfolactate + NADPH + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47929""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-019_3519394e5747	RHEA:47929	pathwaymech:produces	CHEBI:61289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47929		"[{""reference_id"": ""RHEA:47929"", ""source_assertion"": ""RHEA:47929 assigns CHEBI:61289 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47929\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47928_R\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47928_compound_6369\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_6369)""}]"	"[{""id"": ""RHEA:47929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""(2S)-3-sulfolactaldehyde + NADP(+) + H2O => (2S)-3-sulfolactate + NADPH + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47929""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-020_e942373c0442	RHEA:47929	pathwaymech:produces	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47929		"[{""reference_id"": ""RHEA:47929"", ""source_assertion"": ""RHEA:47929 assigns CHEBI:57783 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47929\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47928_R\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47928_compound_3438\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3438)""}]"	"[{""id"": ""RHEA:47929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""(2S)-3-sulfolactaldehyde + NADP(+) + H2O => (2S)-3-sulfolactate + NADPH + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47929""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-021_e1ca1f8d067c	RHEA:47929	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47929		"[{""reference_id"": ""RHEA:47929"", ""source_assertion"": ""RHEA:47929 assigns CHEBI:15378 to its products with coefficient 2."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47929\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47928_R\""]/rh:contains2[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47928_compound_3249\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3249)""}]"	"[{""id"": ""RHEA:47929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""(2S)-3-sulfolactaldehyde + NADP(+) + H2O => (2S)-3-sulfolactate + NADPH + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47929""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-022_d12ff9db2e16	CHEBI:90109	pathwaymech:consumes	RHEA:47933	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47933		"[{""reference_id"": ""RHEA:47933"", ""source_assertion"": ""RHEA:47933 assigns CHEBI:90109 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47933\""]/rh:substrates; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47932_L\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47932_compound_12045\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_12045)""}]"	"[{""id"": ""RHEA:47933"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""(2S)-3-sulfolactaldehyde + NAD(+) + H2O => (2S)-3-sulfolactate + NADH + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47933""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-023_a8ddad4809f4	CHEBI:57540	pathwaymech:consumes	RHEA:47933	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47933		"[{""reference_id"": ""RHEA:47933"", ""source_assertion"": ""RHEA:47933 assigns CHEBI:57540 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47933\""]/rh:substrates; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47932_L\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47932_compound_3484\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3484)""}]"	"[{""id"": ""RHEA:47933"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""(2S)-3-sulfolactaldehyde + NAD(+) + H2O => (2S)-3-sulfolactate + NADH + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47933""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-024_f25ff1fe8b08	CHEBI:15377	pathwaymech:consumes	RHEA:47933	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47933		"[{""reference_id"": ""RHEA:47933"", ""source_assertion"": ""RHEA:47933 assigns CHEBI:15377 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47933\""]/rh:substrates; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47932_L\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47932_compound_1283\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_1283)""}]"	"[{""id"": ""RHEA:47933"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""(2S)-3-sulfolactaldehyde + NAD(+) + H2O => (2S)-3-sulfolactate + NADH + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47933""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-025_603cbdc5c525	RHEA:47933	pathwaymech:produces	CHEBI:61289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47933		"[{""reference_id"": ""RHEA:47933"", ""source_assertion"": ""RHEA:47933 assigns CHEBI:61289 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47933\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47932_R\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47932_compound_6369\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_6369)""}]"	"[{""id"": ""RHEA:47933"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""(2S)-3-sulfolactaldehyde + NAD(+) + H2O => (2S)-3-sulfolactate + NADH + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47933""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-026_32583b37cbe3	RHEA:47933	pathwaymech:produces	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47933		"[{""reference_id"": ""RHEA:47933"", ""source_assertion"": ""RHEA:47933 assigns CHEBI:57945 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47933\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47932_R\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47932_compound_1650\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_1650)""}]"	"[{""id"": ""RHEA:47933"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""(2S)-3-sulfolactaldehyde + NAD(+) + H2O => (2S)-3-sulfolactate + NADH + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47933""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-027_b74e81ec9948	RHEA:47933	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47933		"[{""reference_id"": ""RHEA:47933"", ""source_assertion"": ""RHEA:47933 assigns CHEBI:15378 to its products with coefficient 2."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47933\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47932_R\""]/rh:contains2[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47932_compound_3249\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_3249)""}]"	"[{""id"": ""RHEA:47933"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""(2S)-3-sulfolactaldehyde + NAD(+) + H2O => (2S)-3-sulfolactate + NADH + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47933""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-028_cf1dc6c33a0c	RHEA:47897	BFO:0000050	MetaCyc:PWY-7722	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7722|MetaCyc:RXN-17096|RHEA:47897		"[{""reference_id"": ""MetaCyc:PWY-7722"", ""source_assertion"": ""The complete native pathway lists RXN-17096 among its five reaction members."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-7722\""]/reaction-list/Reaction[@frameid=\""RXN-17096\""]""}, {""reference_id"": ""MetaCyc:RXN-17096"", ""source_assertion"": ""The native reaction cross-references RHEA:47897 and records physiological left-to-right orientation."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-17096\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""RHEA:47897"", ""source_assertion"": ""Rhea master 47896 explicitly has directional reaction 47897; its left-to-right substrate and product assignment is used here."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47896\""]/rh:directionalReaction[@rdf:resource=\""http://rdf.rhea-db.org/47897\""]; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47897\""]/rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:PWY-7722"", ""source_sha256"": ""99e2817a7fa24b23192f0a765629840443e117d68b20a1d0edac3fd264c2d0f4"", ""source_version"": ""MetaCyc 22.5 public mirror; full original XML retrieved 2026-10-11"", ""title"": ""sulfoquinovose degradation II"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7722""}, {""id"": ""MetaCyc:RXN-17096"", ""source_sha256"": ""a09ebed0103a50e86c881214ae0c31c5518120395260bc39dbcf34e1170a0da1"", ""source_version"": ""MetaCyc 22.5 public mirror; full original XML retrieved 2026-10-11"", ""title"": ""RXN-17096"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-17096""}, {""id"": ""RHEA:47897"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-sulfo-D-quinovose + NAD(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + NADH + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47897""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-029_3cc6b40b4b90	RHEA:47909	BFO:0000050	MetaCyc:PWY-7722	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7722|MetaCyc:RXN-17095|RHEA:47909		"[{""reference_id"": ""MetaCyc:PWY-7722"", ""source_assertion"": ""The complete native pathway lists RXN-17095 among its five reaction members."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-7722\""]/reaction-list/Reaction[@frameid=\""RXN-17095\""]""}, {""reference_id"": ""MetaCyc:RXN-17095"", ""source_assertion"": ""The native reaction cross-references RHEA:47909 and records physiological left-to-right orientation."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-17095\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""RHEA:47909"", ""source_assertion"": ""Rhea master 47908 explicitly has directional reaction 47909; its left-to-right substrate and product assignment is used here."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47908\""]/rh:directionalReaction[@rdf:resource=\""http://rdf.rhea-db.org/47909\""]; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47909\""]/rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:PWY-7722"", ""source_sha256"": ""99e2817a7fa24b23192f0a765629840443e117d68b20a1d0edac3fd264c2d0f4"", ""source_version"": ""MetaCyc 22.5 public mirror; full original XML retrieved 2026-10-11"", ""title"": ""sulfoquinovose degradation II"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7722""}, {""id"": ""MetaCyc:RXN-17095"", ""source_sha256"": ""4f39b6fc92e4b39d3079f4b3a0f41d088dddee457af5e4774cfbb2be1f30e4fa"", ""source_version"": ""MetaCyc 22.5 public mirror; full original XML retrieved 2026-10-11"", ""title"": ""RXN-17095"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-17095""}, {""id"": ""RHEA:47909"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O => 6-deoxy-6-sulfo-D-gluconate + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47909""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-030_e5819b94ee83	RHEA:47913	BFO:0000050	MetaCyc:PWY-7722	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7722|MetaCyc:RXN-17097|RHEA:47913		"[{""reference_id"": ""MetaCyc:PWY-7722"", ""source_assertion"": ""The complete native pathway lists RXN-17097 among its five reaction members."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-7722\""]/reaction-list/Reaction[@frameid=\""RXN-17097\""]""}, {""reference_id"": ""MetaCyc:RXN-17097"", ""source_assertion"": ""The native reaction cross-references RHEA:47913 and records physiological left-to-right orientation."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-17097\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""RHEA:47913"", ""source_assertion"": ""Rhea master 47912 explicitly has directional reaction 47913; its left-to-right substrate and product assignment is used here."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47912\""]/rh:directionalReaction[@rdf:resource=\""http://rdf.rhea-db.org/47913\""]; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47913\""]/rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:PWY-7722"", ""source_sha256"": ""99e2817a7fa24b23192f0a765629840443e117d68b20a1d0edac3fd264c2d0f4"", ""source_version"": ""MetaCyc 22.5 public mirror; full original XML retrieved 2026-10-11"", ""title"": ""sulfoquinovose degradation II"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7722""}, {""id"": ""MetaCyc:RXN-17097"", ""source_sha256"": ""58b474bddc570e9cbb155268648d85a08035febb6f559d14464e5cc8c950a5da"", ""source_version"": ""MetaCyc 22.5 public mirror; full original XML retrieved 2026-10-11"", ""title"": ""RXN-17097"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-17097""}, {""id"": ""RHEA:47913"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-deoxy-6-sulfo-D-gluconate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O"", ""url"": ""https://www.rhea-db.org/rhea/47913""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-031_84f202947d16	RHEA:47925	BFO:0000050	MetaCyc:PWY-7722	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7722|MetaCyc:RXN-17098|RHEA:47925		"[{""reference_id"": ""MetaCyc:PWY-7722"", ""source_assertion"": ""The complete native pathway lists RXN-17098 among its five reaction members."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-7722\""]/reaction-list/Reaction[@frameid=\""RXN-17098\""]""}, {""reference_id"": ""MetaCyc:RXN-17098"", ""source_assertion"": ""The native reaction cross-references RHEA:47925 and records physiological left-to-right orientation."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-17098\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid; /ptools-xml/Reaction/reaction-direction""}, {""reference_id"": ""RHEA:47925"", ""source_assertion"": ""Rhea master 47924 explicitly has directional reaction 47925; its left-to-right substrate and product assignment is used here."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47924\""]/rh:directionalReaction[@rdf:resource=\""http://rdf.rhea-db.org/47925\""]; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47925\""]/rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:PWY-7722"", ""source_sha256"": ""99e2817a7fa24b23192f0a765629840443e117d68b20a1d0edac3fd264c2d0f4"", ""source_version"": ""MetaCyc 22.5 public mirror; full original XML retrieved 2026-10-11"", ""title"": ""sulfoquinovose degradation II"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7722""}, {""id"": ""MetaCyc:RXN-17098"", ""source_sha256"": ""62b14fc7e9a8fa9e1c46841f5a0f07fd3581d3192af0ad3857a350496561462b"", ""source_version"": ""MetaCyc 22.5 public mirror; full original XML retrieved 2026-10-11"", ""title"": ""RXN-17098"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-17098""}, {""id"": ""RHEA:47925"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate => (2S)-3-sulfolactaldehyde + pyruvate"", ""url"": ""https://www.rhea-db.org/rhea/47925""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-032_7130c79fefc9	RHEA:47929	BFO:0000050	MetaCyc:PWY-7722	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7722|MetaCyc:RXN-17101|RHEA:47929|UniProtKB:P0DOV9		"[{""reference_id"": ""MetaCyc:PWY-7722"", ""source_assertion"": ""The complete native pathway lists RXN-17101 among its five reaction members."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-7722\""]/reaction-list/Reaction[@frameid=\""RXN-17101\""]""}, {""reference_id"": ""MetaCyc:RXN-17101"", ""source_assertion"": ""The native final reaction uses generic NAD(P)+ and NAD(P)H classes and links RHEA:47929. Its complete cofactor scope is represented by alternative NADP- and NAD-dependent activities, not two consecutive oxidations."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-17101\""]/left; /ptools-xml/Reaction/right; /ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""UniProtKB:P0DOV9"", ""source_assertion"": ""ECO:0000269 (PMID26195800): the reviewed SQ1 protein explicitly assigns the NADP-dependent activity to RHEA:47928."", ""source_locator"": ""/comments/1/reaction/name; /comments/1/reaction/reactionCrossReferences/0; /comments/1/reaction/evidences""}, {""reference_id"": ""RHEA:47929"", ""source_assertion"": ""Rhea master 47928 explicitly has directional reaction 47929; its left-to-right substrate and product assignment is used here."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47928\""]/rh:directionalReaction[@rdf:resource=\""http://rdf.rhea-db.org/47929\""]; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47929\""]/rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:PWY-7722"", ""source_sha256"": ""99e2817a7fa24b23192f0a765629840443e117d68b20a1d0edac3fd264c2d0f4"", ""source_version"": ""MetaCyc 22.5 public mirror; full original XML retrieved 2026-10-11"", ""title"": ""sulfoquinovose degradation II"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7722""}, {""id"": ""MetaCyc:RXN-17101"", ""source_sha256"": ""56a6675908d1a19f36f93f1281a84f0781b948473beb56aab6447b70616e1b47"", ""source_version"": ""MetaCyc 22.5 public mirror; full original XML retrieved 2026-10-11"", ""title"": ""RXN-17101"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-17101""}, {""id"": ""RHEA:47929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""(2S)-3-sulfolactaldehyde + NADP(+) + H2O => (2S)-3-sulfolactate + NADPH + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47929""}, {""id"": ""UniProtKB:P0DOV9"", ""source_sha256"": ""6531fc0a96b3975502f6ac4befa17ea0137d3f4055edb8fb4769b2c7f65cb100"", ""source_version"": ""Complete reviewed entry JSON retrieved 2026-10-11; entry version 25, sequence version 1; last annotation 2026-09-02"", ""title"": ""3-sulfolactaldehyde dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0DOV9.json""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-033_b988248a8086	RHEA:47933	BFO:0000050	MetaCyc:PWY-7722	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7722|MetaCyc:RXN-17101|RHEA:47933|UniProtKB:P0DOV9		"[{""reference_id"": ""MetaCyc:PWY-7722"", ""source_assertion"": ""The complete native pathway lists RXN-17101 among its five reaction members."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-7722\""]/reaction-list/Reaction[@frameid=\""RXN-17101\""]""}, {""reference_id"": ""MetaCyc:RXN-17101"", ""source_assertion"": ""The native final reaction uses generic NAD(P)+ and NAD(P)H classes and links RHEA:47929. Its complete cofactor scope is represented by alternative NADP- and NAD-dependent activities, not two consecutive oxidations."", ""source_locator"": ""/ptools-xml/Reaction[@frameid=\""RXN-17101\""]/left; /ptools-xml/Reaction/right; /ptools-xml/Reaction/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""UniProtKB:P0DOV9"", ""source_assertion"": ""ECO:0000269 (PMID26195800): the reviewed SQ1 protein explicitly assigns the NAD-dependent activity to RHEA:47932."", ""source_locator"": ""/comments/2/reaction/name; /comments/2/reaction/reactionCrossReferences/0; /comments/2/reaction/evidences""}, {""reference_id"": ""RHEA:47933"", ""source_assertion"": ""Rhea master 47932 explicitly has directional reaction 47933; its left-to-right substrate and product assignment is used here."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47932\""]/rh:directionalReaction[@rdf:resource=\""http://rdf.rhea-db.org/47933\""]; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47933\""]/rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:PWY-7722"", ""source_sha256"": ""99e2817a7fa24b23192f0a765629840443e117d68b20a1d0edac3fd264c2d0f4"", ""source_version"": ""MetaCyc 22.5 public mirror; full original XML retrieved 2026-10-11"", ""title"": ""sulfoquinovose degradation II"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7722""}, {""id"": ""MetaCyc:RXN-17101"", ""source_sha256"": ""56a6675908d1a19f36f93f1281a84f0781b948473beb56aab6447b70616e1b47"", ""source_version"": ""MetaCyc 22.5 public mirror; full original XML retrieved 2026-10-11"", ""title"": ""RXN-17101"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-17101""}, {""id"": ""RHEA:47933"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""(2S)-3-sulfolactaldehyde + NAD(+) + H2O => (2S)-3-sulfolactate + NADH + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47933""}, {""id"": ""UniProtKB:P0DOV9"", ""source_sha256"": ""6531fc0a96b3975502f6ac4befa17ea0137d3f4055edb8fb4769b2c7f65cb100"", ""source_version"": ""Complete reviewed entry JSON retrieved 2026-10-11; entry version 25, sequence version 1; last annotation 2026-09-02"", ""title"": ""3-sulfolactaldehyde dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0DOV9.json""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-034_e32ea33b2de3	UniProtKB:P0DOV5	pathwaymech:enables	RHEA:47897	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:26195800|PMID:39840830|UniProtKB:P0DOV5	Functional protein/activity relation, not monomer sufficiency. The 2025 recombinant SQ1 enzyme is tetrameric in solution and crystals. Minor NADP activity and trace G6P activity are assay-dependent side activities outside the native NAD-dependent step.	"[{""reference_id"": ""UniProtKB:P0DOV5"", ""source_assertion"": ""ECO:0000269, PMID26195800: this reviewed SQ1 gene product is assigned the specified catalytic activity; its cited genomic and experimental references explicitly name strain SQ1."", ""source_locator"": ""/comments/1/reaction; /references/0/referenceComments; /references/1/referenceComments""}, {""reference_id"": ""PMID:26195800"", ""source_assertion"": ""SQ1 IMG0090 was cloned and purified from recombinant E. coli; it oxidized SQ to SGL with a strong NAD+ preference. Whole-pathway reconstitution used the purified protein."", ""source_locator"": ""//*[@id=\""s4\""]/p[1]; //*[@id=\""s5\""]/p[2]; Figure 4B; SI Heterologous Overproduction and Purification of His-Tagged Proteins""}, {""reference_id"": ""PMID:39840830"", ""source_assertion"": ""The codon-harmonized SQ1 SQDH construct has a tetrameric solution state by SEC-MALLS (~119 kDa versus ~28 kDa monomer), consistent with its crystals. The published untagged sequence equals P0DOV5."", ""source_locator"": ""//*[@id=\""s2-2\""]/p[1]; Figure 4; //*[@id=\""s5-2\""]; //*[@id=\""s5-3\""]/p[1]""}, {""reference_id"": ""PMID:39840830"", ""source_assertion"": ""Under the 2025 kinetic conditions, NAD+ was favored over NADP+ by about 10^6 in catalytic efficiency, and very weak G6P turnover was detectable at high enzyme concentration; the 2015 negative assay is condition-specific."", ""source_locator"": ""//*[@id=\""s2-1\""]/p[1]; //*[@id=\""s2-1\""]/p[2]; Table 1""}]"	"[{""id"": ""PMID:26195800"", ""source_sha256"": ""e82307720415251fbe81a8293ed7078effeb5e268502c5776ce9b30f632e8afc"", ""source_version"": ""Original 2015 full primary article including SI methods, tables and figure legends in publisher-deposited PMC HTML; retrieved 2026-10-11"", ""title"": ""Entner-Doudoroff pathway for sulfoquinovose degradation in Pseudomonas putida SQ1."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC4534283/?pdf=render""}, {""id"": ""PMID:39840830"", ""source_sha256"": ""d3059313116aeac892709ea5a759bc1900fc4f47e8d021ff965a5a3c557f36b3"", ""source_version"": ""Original 2025 full primary PMC HTML, including complete construct sequences and Methods; retrieved 2026-10-11"", ""title"": ""Structure, kinetics, and mechanism of Pseudomonas putida sulfoquinovose dehydrogenase, the first enzyme in the sulfoglycolytic Entner-Doudoroff pathway."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC12133307/?pdf=render""}, {""id"": ""UniProtKB:P0DOV5"", ""source_sha256"": ""c39828a60a1c3ba040a95bd392a9d1514fa8b2134cf5d1bc2fa7ae475b9ebd24"", ""source_version"": ""Complete reviewed entry JSON retrieved 2026-10-11; entry version 25, sequence version 1; last annotation 2026-09-02"", ""title"": ""Sulfoquinovose 1-dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0DOV5.json""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-035_84fb7a58a7b5	UniProtKB:P0DOV6	pathwaymech:enables	RHEA:47909	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:26195800|UniProtKB:P0DOV6	Functional activity assignment. Divalent-metal binding below is a reviewed similarity inference, not an SQ1 metal-titration measurement. No physical monomer or oligomer state is inferred from the native MONOMER frame name.	"[{""reference_id"": ""UniProtKB:P0DOV6"", ""source_assertion"": ""ECO:0000269, PMID26195800: this reviewed SQ1 gene product is assigned the specified catalytic activity; its cited genomic and experimental references explicitly name strain SQ1."", ""source_locator"": ""/comments/1/reaction; /references/0/referenceComments; /references/1/referenceComments""}, {""reference_id"": ""PMID:26195800"", ""source_assertion"": ""Purified recombinant SQ1 IMG0091 converted SGL to SG in sequential reconstitution. Minor spontaneous hydrolysis was also observed before lactonase addition; it does not replace the enzyme-supported native step."", ""source_locator"": ""//*[@id=\""s5\""]/p[1]; //*[@id=\""s5\""]/p[2]; Figure 4B-C""}]"	"[{""id"": ""PMID:26195800"", ""source_sha256"": ""e82307720415251fbe81a8293ed7078effeb5e268502c5776ce9b30f632e8afc"", ""source_version"": ""Original 2015 full primary article including SI methods, tables and figure legends in publisher-deposited PMC HTML; retrieved 2026-10-11"", ""title"": ""Entner-Doudoroff pathway for sulfoquinovose degradation in Pseudomonas putida SQ1."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC4534283/?pdf=render""}, {""id"": ""UniProtKB:P0DOV6"", ""source_sha256"": ""c2c78a34870f5edbf56ec4d4ee56fe715cdebad570050ffcb8e159b87a378ab9"", ""source_version"": ""Complete reviewed entry JSON retrieved 2026-10-11; entry version 21, sequence version 1; last annotation 2026-06-10"", ""title"": ""6-deoxy-6-sulfogluconolactonase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0DOV6.json""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-036_8504cbfea27d	UniProtKB:P0DOV7	pathwaymech:enables	RHEA:47913	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:26195800|UniProtKB:P0DOV7	Functional activity assignment; current reviewed homodimer and one [4Fe-4S] cluster annotations are inferred by similarity to Q1JUQ1, not directly measured SQ1 assembly or cluster occupancy.	"[{""reference_id"": ""UniProtKB:P0DOV7"", ""source_assertion"": ""ECO:0000269, PMID26195800: this reviewed SQ1 gene product is assigned the specified catalytic activity; its cited genomic and experimental references explicitly name strain SQ1."", ""source_locator"": ""/comments/1/reaction; /references/0/referenceComments; /references/1/referenceComments""}, {""reference_id"": ""PMID:26195800"", ""source_assertion"": ""Purified recombinant SQ1 IMG0089 converted SG to KDSG in the sequential reconstitution; its preparation also contained C-terminally truncated products identified by peptide fingerprinting."", ""source_locator"": ""//*[@id=\""s5\""]/p[1]; //*[@id=\""s5\""]/p[2]; Figure 4C-D; Figure S4 legend""}, {""reference_id"": ""UniProtKB:P0DOV7"", ""source_assertion"": ""The homodimer annotation is ECO:0000250 inference from Q1JUQ1. It is not direct experimental assembly evidence for SQ1."", ""source_locator"": ""/comments/3/texts/0""}]"	"[{""id"": ""PMID:26195800"", ""source_sha256"": ""e82307720415251fbe81a8293ed7078effeb5e268502c5776ce9b30f632e8afc"", ""source_version"": ""Original 2015 full primary article including SI methods, tables and figure legends in publisher-deposited PMC HTML; retrieved 2026-10-11"", ""title"": ""Entner-Doudoroff pathway for sulfoquinovose degradation in Pseudomonas putida SQ1."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC4534283/?pdf=render""}, {""id"": ""UniProtKB:P0DOV7"", ""source_sha256"": ""0566981bd12cca55a07e8a7bb627a5798bbb41859b6168e9aaf2a2f6e6e02ee8"", ""source_version"": ""Complete reviewed entry JSON retrieved 2026-10-11; entry version 26, sequence version 1; last annotation 2026-09-02"", ""title"": ""6-deoxy-6-sulfo-D-gluconate dehydratase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0DOV7.json""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-037_3022be361192	UniProtKB:P0DOV8	pathwaymech:enables	RHEA:47925	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	NCBIProtein:KHL76360.1|PMID:26195800|PMID:41830472|UniProtKB:P0DOV8	Functional assignment of the reviewed SQ1 gene product. The 2015 cloned IMG00100 gene uses an upstream start relative to the current GenBank annotation at the same locus. Native prose has stale R-SLA/family annotations; current native reaction and Rhea/UniProt chemistry select S-SLA. No monomer sufficiency is asserted.	"[{""reference_id"": ""UniProtKB:P0DOV8"", ""source_assertion"": ""ECO:0000269, PMID26195800: this reviewed SQ1 gene product is assigned the specified catalytic activity; its cited genomic and experimental references explicitly name strain SQ1."", ""source_locator"": ""/comments/1/reaction; /references/0/referenceComments; /references/1/referenceComments""}, {""reference_id"": ""PMID:26195800"", ""source_assertion"": ""Purified recombinant SQ1 IMG0100 cleaved KDSG to SLA and pyruvate. Pyruvate was verified by a positive lactate-dehydrogenase assay and HPLC cochromatography; the SLA assay was not enantiomer-resolved."", ""source_locator"": ""//*[@id=\""s5\""]/p[1]; //*[@id=\""s5\""]/p[2]; Figure 4D-E""}, {""reference_id"": ""PMID:26195800"", ""source_assertion"": ""The cloned IMG00100 used forward primer CACCATGTCCACTGCTGTCACG. All recombinant inserts came from SQ1 chromosomal DNA and were sequence-verified; the paper does not specify current UniProt accessions."", ""source_locator"": ""//*[@id=\""si8\""]/p[1]; Table S2, PpSQ1_00100f row""}, {""reference_id"": ""NCBIProtein:KHL76360.1"", ""source_assertion"": ""The original SQ1 protein record locates PpSQ1_00455 at complement(JTCJ01000004.1:18793..19560). This is the current annotated gene call, not a claim that its N terminus equals the longer 2015 construct."", ""source_locator"": ""/GBSet/GBSeq/GBSeq_feature-table/GBFeature[GBFeature_key=\""source\""]/GBFeature_quals; /GBSet/GBSeq/GBSeq_feature-table/GBFeature[GBFeature_key=\""CDS\""]/GBFeature_quals; /GBSet/GBSeq/GBSeq_sequence""}, {""reference_id"": ""PMID:41830472"", ""source_assertion"": ""The 2026 P. putida aldolase abstract reports a homohexamer, optimal Co/Mn activity and modest KDPG cross-reactivity. The accessible abstract does not expose its strain or construct sequence; these details are contextual and are not transferred as direct SQ1 assembly/metal assignments."", ""source_locator"": ""/resultList/result[0]/abstractText""}]"	"[{""id"": ""NCBIProtein:KHL76360.1"", ""source_sha256"": ""8736f6a5439a022c10f154cafdeb607f32515739d029ccbfe72020b7bf5165e7"", ""source_version"": ""Original accession-version GBSet/GBSeq XML retrieved 2026-10-11; sequence and strain/CDS identity only, automated original functional name not imported"", ""title"": ""SQ1 PpSQ1_00455 protein and genomic CDS annotation"", ""url"": ""https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=protein&id=KHL76360.1&rettype=gb&retmode=xml""}, {""id"": ""PMID:26195800"", ""source_sha256"": ""e82307720415251fbe81a8293ed7078effeb5e268502c5776ce9b30f632e8afc"", ""source_version"": ""Original 2015 full primary article including SI methods, tables and figure legends in publisher-deposited PMC HTML; retrieved 2026-10-11"", ""title"": ""Entner-Doudoroff pathway for sulfoquinovose degradation in Pseudomonas putida SQ1."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC4534283/?pdf=render""}, {""id"": ""PMID:41830472"", ""source_sha256"": ""bfaee9c036939b4db87a8076aacfcebd894569f3f7a31fab54d5a28b49a3c055"", ""source_version"": ""Original 2026 primary abstract only, through Europe PMC single-PMID core JSON; full article/SI unavailable and deposited structure API requests returned404; retrieved 2026-10-11"", ""title"": ""Metal-Dependent 2-Keto-3,6-dideoxy-6-sulfo-gluconate (KDSG) Aldolase: Decoding the Key C-C Bond Cleaving Step in Bacterial Sulfoglycolysis."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:41830472%20AND%20SRC:MED&resultType=core&format=json""}, {""id"": ""UniProtKB:P0DOV8"", ""source_sha256"": ""16dc1c10fef8e123b0b42f19cfe81abfbe68e0bd2c534ee6125d425d14e51021"", ""source_version"": ""Complete reviewed entry JSON retrieved 2026-10-11; entry version 21, sequence version 1; last annotation 2026-09-02"", ""title"": ""2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0DOV8.json""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-038_23672ce28ce9	UniProtKB:P0DOV9	pathwaymech:enables	RHEA:47929	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:26195800|PMID:37886098|UniProtKB:P0DOV9	Alternative NADP- and NAD-dependent final activity, not sequential steps. Current Rhea/UniProt and native reaction sides select S-SLA/S-SL; stale native protein prose links R-SLA. The SQ1 HPLC-MS assay was not an independent enantiomer-resolved characterization.	"[{""reference_id"": ""UniProtKB:P0DOV9"", ""source_assertion"": ""ECO:0000269, PMID26195800: this reviewed SQ1 gene product is assigned the specified catalytic activity; its cited genomic and experimental references explicitly name strain SQ1."", ""source_locator"": ""/comments/1/reaction; /references/0/referenceComments; /references/1/referenceComments""}, {""reference_id"": ""PMID:26195800"", ""source_assertion"": ""Purified recombinant SQ1 IMG0088 oxidized SLA to SL with both NAD+ and NADP+. Published kinetic constants used succinate semialdehyde because the SLA concentration was undefined; no SLA Km is assigned here."", ""source_locator"": ""//*[@id=\""s4\""]/p[2]; Table 1 and footnote; Figure 4E-F""}, {""reference_id"": ""PMID:37886098"", ""source_assertion"": ""The later tetramer and stereoselectivity experiments concern Rhizobium leguminosarum SRDI565 RlGabD, not SQ1. They are not transferred as direct assembly or enantiomer-assay evidence for P0DOV9."", ""source_locator"": ""//*[@id=\""abstract1\""]/p[1]; //*[@id=\""sec3\""]/p[1]; //*[@id=\""sec6\""]/p[1]""}]"	"[{""id"": ""PMID:26195800"", ""source_sha256"": ""e82307720415251fbe81a8293ed7078effeb5e268502c5776ce9b30f632e8afc"", ""source_version"": ""Original 2015 full primary article including SI methods, tables and figure legends in publisher-deposited PMC HTML; retrieved 2026-10-11"", ""title"": ""Entner-Doudoroff pathway for sulfoquinovose degradation in Pseudomonas putida SQ1."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC4534283/?pdf=render""}, {""id"": ""PMID:37886098"", ""source_sha256"": ""e5e213c79ca6b4b0b5648555bc91d6af4e373f6f7cb2d389a0ded2effcbaa735"", ""source_version"": ""Original 2023 primary full PMC HTML; other-organism scope, inspected as a transfer limit; retrieved 2026-10-11"", ""title"": ""Molecular basis of sulfolactate synthesis by sulfolactaldehyde dehydrogenase from Rhizobium leguminosarum."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC10599462/?pdf=render""}, {""id"": ""UniProtKB:P0DOV9"", ""source_sha256"": ""6531fc0a96b3975502f6ac4befa17ea0137d3f4055edb8fb4769b2c7f65cb100"", ""source_version"": ""Complete reviewed entry JSON retrieved 2026-10-11; entry version 25, sequence version 1; last annotation 2026-09-02"", ""title"": ""3-sulfolactaldehyde dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0DOV9.json""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-039_7ea8229dbfd4	UniProtKB:P0DOV9	pathwaymech:enables	RHEA:47933	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:26195800|PMID:37886098|UniProtKB:P0DOV9	Alternative NADP- and NAD-dependent final activity, not sequential steps. Current Rhea/UniProt and native reaction sides select S-SLA/S-SL; stale native protein prose links R-SLA. The SQ1 HPLC-MS assay was not an independent enantiomer-resolved characterization.	"[{""reference_id"": ""UniProtKB:P0DOV9"", ""source_assertion"": ""ECO:0000269, PMID26195800: this reviewed SQ1 gene product is assigned the specified catalytic activity; its cited genomic and experimental references explicitly name strain SQ1."", ""source_locator"": ""/comments/2/reaction; /references/0/referenceComments; /references/1/referenceComments""}, {""reference_id"": ""PMID:26195800"", ""source_assertion"": ""Purified recombinant SQ1 IMG0088 oxidized SLA to SL with both NAD+ and NADP+. Published kinetic constants used succinate semialdehyde because the SLA concentration was undefined; no SLA Km is assigned here."", ""source_locator"": ""//*[@id=\""s4\""]/p[2]; Table 1 and footnote; Figure 4E-F""}, {""reference_id"": ""PMID:37886098"", ""source_assertion"": ""The later tetramer and stereoselectivity experiments concern Rhizobium leguminosarum SRDI565 RlGabD, not SQ1. They are not transferred as direct assembly or enantiomer-assay evidence for P0DOV9."", ""source_locator"": ""//*[@id=\""abstract1\""]/p[1]; //*[@id=\""sec3\""]/p[1]; //*[@id=\""sec6\""]/p[1]""}]"	"[{""id"": ""PMID:26195800"", ""source_sha256"": ""e82307720415251fbe81a8293ed7078effeb5e268502c5776ce9b30f632e8afc"", ""source_version"": ""Original 2015 full primary article including SI methods, tables and figure legends in publisher-deposited PMC HTML; retrieved 2026-10-11"", ""title"": ""Entner-Doudoroff pathway for sulfoquinovose degradation in Pseudomonas putida SQ1."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC4534283/?pdf=render""}, {""id"": ""PMID:37886098"", ""source_sha256"": ""e5e213c79ca6b4b0b5648555bc91d6af4e373f6f7cb2d389a0ded2effcbaa735"", ""source_version"": ""Original 2023 primary full PMC HTML; other-organism scope, inspected as a transfer limit; retrieved 2026-10-11"", ""title"": ""Molecular basis of sulfolactate synthesis by sulfolactaldehyde dehydrogenase from Rhizobium leguminosarum."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC10599462/?pdf=render""}, {""id"": ""UniProtKB:P0DOV9"", ""source_sha256"": ""6531fc0a96b3975502f6ac4befa17ea0137d3f4055edb8fb4769b2c7f65cb100"", ""source_version"": ""Complete reviewed entry JSON retrieved 2026-10-11; entry version 25, sequence version 1; last annotation 2026-09-02"", ""title"": ""3-sulfolactaldehyde dehydrogenase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0DOV9.json""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-040_ec89a63e4777	UniProtKB:P0DOV6	pathwaymech:has_cofactor	CHEBI:60240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0DOV6		"[{""reference_id"": ""UniProtKB:P0DOV6"", ""source_assertion"": ""ECO:0000250 inference from Q15493: the reviewed entry assigns one divalent metal cation per subunit. This is a similarity annotation, not direct SQ1 metal identity or occupancy measurement."", ""source_locator"": ""/comments/2/cofactors/0; /comments/2/note/texts/0""}]"	"[{""id"": ""UniProtKB:P0DOV6"", ""source_sha256"": ""c2c78a34870f5edbf56ec4d4ee56fe715cdebad570050ffcb8e159b87a378ab9"", ""source_version"": ""Complete reviewed entry JSON retrieved 2026-10-11; entry version 21, sequence version 1; last annotation 2026-06-10"", ""title"": ""6-deoxy-6-sulfogluconolactonase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0DOV6.json""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-041_697703e6a24a	UniProtKB:P0DOV7	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0DOV7		"[{""reference_id"": ""UniProtKB:P0DOV7"", ""source_assertion"": ""ECO:0000250 inference from Q1JUQ1: the reviewed entry assigns one [4Fe-4S] cluster. This is a similarity annotation, not direct SQ1 metal identity or occupancy measurement."", ""source_locator"": ""/comments/2/cofactors/0; /comments/2/note/texts/0""}]"	"[{""id"": ""UniProtKB:P0DOV7"", ""source_sha256"": ""0566981bd12cca55a07e8a7bb627a5798bbb41859b6168e9aaf2a2f6e6e02ee8"", ""source_version"": ""Complete reviewed entry JSON retrieved 2026-10-11; entry version 26, sequence version 1; last annotation 2026-09-02"", ""title"": ""6-deoxy-6-sulfo-D-gluconate dehydratase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0DOV7.json""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-042_ec0211e5d91d	UniProtKB:P0DOV8	pathwaymech:has_cofactor	CHEBI:60240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0DOV8		"[{""reference_id"": ""UniProtKB:P0DOV8"", ""source_assertion"": ""ECO:0000250 inference from Q47098: the reviewed entry assigns one divalent metal cation per subunit. This is a similarity annotation, not direct SQ1 metal identity or occupancy measurement."", ""source_locator"": ""/comments/2/cofactors/0; /comments/2/note/texts/0""}]"	"[{""id"": ""UniProtKB:P0DOV8"", ""source_sha256"": ""16dc1c10fef8e123b0b42f19cfe81abfbe68e0bd2c534ee6125d425d14e51021"", ""source_version"": ""Complete reviewed entry JSON retrieved 2026-10-11; entry version 21, sequence version 1; last annotation 2026-09-02"", ""title"": ""2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0DOV8.json""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-043_50805e56cb51	RHEA:47897	RO:0002413	RHEA:47909	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7722|RHEA:47897|RHEA:47909		"[{""reference_id"": ""MetaCyc:PWY-7722"", ""source_assertion"": ""The native predecessor list places RXN-17096 before RXN-17095. This citation supports native order; the shared current chemical identity is separately grounded in Rhea."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-7722\""]/reaction-ordering[Reaction/@frameid=\""RXN-17095\""]/predecessor-reactions/Reaction[@frameid=\""RXN-17096\""]""}, {""reference_id"": ""RHEA:47897"", ""source_assertion"": ""RHEA:47897 assigns CHEBI:88091 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47897\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47896_R\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47896_compound_11949\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_11949)""}, {""reference_id"": ""RHEA:47909"", ""source_assertion"": ""RHEA:47909 assigns CHEBI:88091 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47909\""]/rh:substrates; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47908_L\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47908_compound_11949\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_11949)""}]"	"[{""id"": ""MetaCyc:PWY-7722"", ""source_sha256"": ""99e2817a7fa24b23192f0a765629840443e117d68b20a1d0edac3fd264c2d0f4"", ""source_version"": ""MetaCyc 22.5 public mirror; full original XML retrieved 2026-10-11"", ""title"": ""sulfoquinovose degradation II"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7722""}, {""id"": ""RHEA:47897"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-sulfo-D-quinovose + NAD(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + NADH + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47897""}, {""id"": ""RHEA:47909"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O => 6-deoxy-6-sulfo-D-gluconate + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47909""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-044_9de1916c39bc	RHEA:47909	RO:0002413	RHEA:47913	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7722|RHEA:47909|RHEA:47913		"[{""reference_id"": ""MetaCyc:PWY-7722"", ""source_assertion"": ""The native predecessor list places RXN-17095 before RXN-17097. This citation supports native order; the shared current chemical identity is separately grounded in Rhea."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-7722\""]/reaction-ordering[Reaction/@frameid=\""RXN-17097\""]/predecessor-reactions/Reaction[@frameid=\""RXN-17095\""]""}, {""reference_id"": ""RHEA:47909"", ""source_assertion"": ""RHEA:47909 assigns CHEBI:88093 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47909\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47908_R\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47908_compound_11950\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_11950)""}, {""reference_id"": ""RHEA:47913"", ""source_assertion"": ""RHEA:47913 assigns CHEBI:88093 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47913\""]/rh:substrates; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47912_L\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47912_compound_11950\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_11950)""}]"	"[{""id"": ""MetaCyc:PWY-7722"", ""source_sha256"": ""99e2817a7fa24b23192f0a765629840443e117d68b20a1d0edac3fd264c2d0f4"", ""source_version"": ""MetaCyc 22.5 public mirror; full original XML retrieved 2026-10-11"", ""title"": ""sulfoquinovose degradation II"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7722""}, {""id"": ""RHEA:47909"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O => 6-deoxy-6-sulfo-D-gluconate + H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47909""}, {""id"": ""RHEA:47913"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-deoxy-6-sulfo-D-gluconate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O"", ""url"": ""https://www.rhea-db.org/rhea/47913""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-045_7f95689c9cb9	RHEA:47913	RO:0002413	RHEA:47925	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7722|RHEA:47913|RHEA:47925		"[{""reference_id"": ""MetaCyc:PWY-7722"", ""source_assertion"": ""The native predecessor list places RXN-17097 before RXN-17098. This citation supports native order; the shared current chemical identity is separately grounded in Rhea."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-7722\""]/reaction-ordering[Reaction/@frameid=\""RXN-17098\""]/predecessor-reactions/Reaction[@frameid=\""RXN-17097\""]""}, {""reference_id"": ""RHEA:47913"", ""source_assertion"": ""RHEA:47913 assigns CHEBI:88094 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47913\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47912_R\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47912_compound_11951\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_11951)""}, {""reference_id"": ""RHEA:47925"", ""source_assertion"": ""RHEA:47925 assigns CHEBI:88094 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47925\""]/rh:substrates; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47924_L\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47924_compound_11951\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_11951)""}]"	"[{""id"": ""MetaCyc:PWY-7722"", ""source_sha256"": ""99e2817a7fa24b23192f0a765629840443e117d68b20a1d0edac3fd264c2d0f4"", ""source_version"": ""MetaCyc 22.5 public mirror; full original XML retrieved 2026-10-11"", ""title"": ""sulfoquinovose degradation II"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7722""}, {""id"": ""RHEA:47913"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""6-deoxy-6-sulfo-D-gluconate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O"", ""url"": ""https://www.rhea-db.org/rhea/47913""}, {""id"": ""RHEA:47925"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate => (2S)-3-sulfolactaldehyde + pyruvate"", ""url"": ""https://www.rhea-db.org/rhea/47925""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-046_abfbacf82d6c	RHEA:47925	RO:0002413	RHEA:47929	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7722|RHEA:47925|RHEA:47929		"[{""reference_id"": ""MetaCyc:PWY-7722"", ""source_assertion"": ""The native predecessor list places RXN-17098 before RXN-17101. This citation supports native order; the shared current chemical identity is separately grounded in Rhea."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-7722\""]/reaction-ordering[Reaction/@frameid=\""RXN-17101\""]/predecessor-reactions/Reaction[@frameid=\""RXN-17098\""]""}, {""reference_id"": ""RHEA:47925"", ""source_assertion"": ""RHEA:47925 assigns CHEBI:90109 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47925\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47924_R\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47924_compound_12045\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_12045)""}, {""reference_id"": ""RHEA:47929"", ""source_assertion"": ""RHEA:47929 assigns CHEBI:90109 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47929\""]/rh:substrates; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47928_L\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47928_compound_12045\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_12045)""}]"	"[{""id"": ""MetaCyc:PWY-7722"", ""source_sha256"": ""99e2817a7fa24b23192f0a765629840443e117d68b20a1d0edac3fd264c2d0f4"", ""source_version"": ""MetaCyc 22.5 public mirror; full original XML retrieved 2026-10-11"", ""title"": ""sulfoquinovose degradation II"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7722""}, {""id"": ""RHEA:47925"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate => (2S)-3-sulfolactaldehyde + pyruvate"", ""url"": ""https://www.rhea-db.org/rhea/47925""}, {""id"": ""RHEA:47929"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""(2S)-3-sulfolactaldehyde + NADP(+) + H2O => (2S)-3-sulfolactate + NADPH + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47929""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-047_a1e913eddc28	RHEA:47925	RO:0002413	RHEA:47933	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-7722|RHEA:47925|RHEA:47933		"[{""reference_id"": ""MetaCyc:PWY-7722"", ""source_assertion"": ""The native predecessor list places RXN-17098 before RXN-17101. This citation supports native order; the shared current chemical identity is separately grounded in Rhea."", ""source_locator"": ""/ptools-xml/Pathway[@frameid=\""PWY-7722\""]/reaction-ordering[Reaction/@frameid=\""RXN-17101\""]/predecessor-reactions/Reaction[@frameid=\""RXN-17098\""]""}, {""reference_id"": ""RHEA:47925"", ""source_assertion"": ""RHEA:47925 assigns CHEBI:90109 to its products with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47925\""]/rh:products; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47924_R\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47924_compound_12045\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_12045)""}, {""reference_id"": ""RHEA:47933"", ""source_assertion"": ""RHEA:47933 assigns CHEBI:90109 to its substrates with coefficient 1."", ""source_locator"": ""rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47933\""]/rh:substrates; rdf:Description[@rdf:about=\""http://rdf.rhea-db.org/47932_L\""]/rh:contains1[@rdf:resource=\""http://rdf.rhea-db.org/Participant_47932_compound_12045\""]; rh:compound/rh:chebi (http://rdf.rhea-db.org/Compound_12045)""}]"	"[{""id"": ""MetaCyc:PWY-7722"", ""source_sha256"": ""99e2817a7fa24b23192f0a765629840443e117d68b20a1d0edac3fd264c2d0f4"", ""source_version"": ""MetaCyc 22.5 public mirror; full original XML retrieved 2026-10-11"", ""title"": ""sulfoquinovose degradation II"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-7722""}, {""id"": ""RHEA:47925"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate => (2S)-3-sulfolactaldehyde + pyruvate"", ""url"": ""https://www.rhea-db.org/rhea/47925""}, {""id"": ""RHEA:47933"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers full original compressed RDF gzip"", ""title"": ""(2S)-3-sulfolactaldehyde + NAD(+) + H2O => (2S)-3-sulfolactate + NADH + 2 H(+)"", ""url"": ""https://www.rhea-db.org/rhea/47933""}]"	""
pathwaymech:MetaCyc_PWY-7722_sulfoed-edge-048_65ad79e9edbe	CHEBI:57945	pathwaymech:inhibits	UniProtKB:P0DOV5	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:39840830	Conditional recombinant-enzyme inhibition; no cellular regulation or new transcription-factor identity is inferred.	"[{""reference_id"": ""PMID:39840830"", ""source_assertion"": ""NADH competitively inhibits NAD+ in the recombinant SQDH product-inhibition assays, supporting an ordered mechanism with NAD+ binding first and NADH leaving last. This is assay-level product inhibition, not a measured cellular flux threshold."", ""source_locator"": ""//*[@id=\""s2-1\""]/p[4]; Figure 3; section 5.5 Enzyme kinetics""}]"	"[{""id"": ""PMID:39840830"", ""source_sha256"": ""d3059313116aeac892709ea5a759bc1900fc4f47e8d021ff965a5a3c557f36b3"", ""source_version"": ""Original 2025 full primary PMC HTML, including complete construct sequences and Methods; retrieved 2026-10-11"", ""title"": ""Structure, kinetics, and mechanism of Pseudomonas putida sulfoquinovose dehydrogenase, the first enzyme in the sulfoglycolytic Entner-Doudoroff pathway."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC12133307/?pdf=render""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-001_2f5f734f8d85	gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257	BFO:0000050	GO:0019430	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257 BFO:0000050 gomodel:YeastPathways_DETOX1-PWY/YeastPathways_DETOX1-PWY."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/0; endpoint types: /individuals/24/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-002_129ba4295ff1	gomodel:CATAL-RXN	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:CATAL-RXN RO:0002234 gomodel:CHEBI_15377_CATAL-RXN."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/1; endpoint types: /individuals/0/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-003_5c13ed3f0405	gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257 RO:0002233 gomodel:YeastPathways_DETOX1-PWY/6a4c244800000258."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/2; endpoint types: /individuals/24/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-004_ed6d9dd661f9	SGD:S000003865	pathwaymech:enables	gomodel:SUPEROX-DISMUT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:SUPEROX-DISMUT-RXN RO:0002333 gomodel:MONOMER3O-1629_SUPEROX-DISMUT-RXN_controller."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/3; endpoint types: /individuals/8/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-005_552d40721379	gomodel:CATAL-RXN	RO:0002234	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:CATAL-RXN RO:0002234 gomodel:CHEBI_15379_CATAL-RXN."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/4; endpoint types: /individuals/0/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-006_51ac0abb843c	gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271	BFO:0000050	GO:0019430	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271 BFO:0000050 gomodel:YeastPathways_DETOX1-PWY/YeastPathways_DETOX1-PWY."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/5; endpoint types: /individuals/37/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-007_58874379962c	gomodel:CATAL-RXN	BFO:0000050	GO:0019430	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:CATAL-RXN BFO:0000050 gomodel:YeastPathways_DETOX1-PWY/YeastPathways_DETOX1-PWY."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/6; endpoint types: /individuals/0/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-008_2db6f6113277	SGD:S000002664	pathwaymech:enables	gomodel:CATAL-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:CATAL-RXN RO:0002333 gomodel:YDR256C-MONOMER_CATAL-RXN_controller."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/7; endpoint types: /individuals/0/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-009_70fcf1f2e199	SGD:S000003320	pathwaymech:enables	gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271 RO:0002333 gomodel:YeastPathways_DETOX1-PWY/6a4c244800000275."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/8; endpoint types: /individuals/37/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-010_1a0ee8fba343	gomodel:SUPEROX-DISMUT-RXN	BFO:0000050	GO:0019430	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:SUPEROX-DISMUT-RXN BFO:0000050 gomodel:YeastPathways_DETOX1-PWY/YeastPathways_DETOX1-PWY."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/9; endpoint types: /individuals/8/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-011_89a12d8e92aa	gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271	RO:0002234	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271 RO:0002234 gomodel:YeastPathways_DETOX1-PWY/6a4c244800000273."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/10; endpoint types: /individuals/37/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-012_5a15103354b2	gomodel:SUPEROX-DISMUT-RXN	RO:0002233	CHEBI:18421	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:SUPEROX-DISMUT-RXN RO:0002233 gomodel:CHEBI_18421_SUPEROX-DISMUT-RXN."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/11; endpoint types: /individuals/8/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-013_50596fd7a872	gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257	RO:0002233	CHEBI:18421	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257 RO:0002233 gomodel:YeastPathways_DETOX1-PWY/6a4c244800000259."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/12; endpoint types: /individuals/24/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-014_92eaa550d56c	gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271 BFO:0000066 gomodel:YeastPathways_DETOX1-PWY/6a4c244800000276."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/13; endpoint types: /individuals/37/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-015_1285fad9433d	gomodel:SUPEROX-DISMUT-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:SUPEROX-DISMUT-RXN RO:0002233 gomodel:CHEBI_15378_SUPEROX-DISMUT-RXN."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/14; endpoint types: /individuals/8/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-016_fc40510bb1d5	gomodel:SUPEROX-DISMUT-RXN	RO:0002234	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:SUPEROX-DISMUT-RXN RO:0002234 gomodel:CHEBI_15379_SUPEROX-DISMUT-RXN."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/15; endpoint types: /individuals/8/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-017_d85ade9e571e	gomodel:SUPEROX-DISMUT-RXN	RO:0002234	CHEBI:16240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:SUPEROX-DISMUT-RXN RO:0002234 gomodel:CHEBI_16240_SUPEROX-DISMUT-RXN."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/16; endpoint types: /individuals/8/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-019_ab15a09b411f	gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271	RO:0002233	CHEBI:16240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271 RO:0002233 gomodel:CHEBI_16240_SUPEROX-DISMUT-RXN."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/18; endpoint types: /individuals/37/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-020_14831914d812	gomodel:CATAL-RXN	RO:0002233	CHEBI:16240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:CATAL-RXN RO:0002233 gomodel:CHEBI_16240_SUPEROX-DISMUT-RXN."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/19; endpoint types: /individuals/0/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-021_237eb48b7816	gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257	RO:0002234	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257 RO:0002234 gomodel:YeastPathways_DETOX1-PWY/6a4c244800000260."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/20; endpoint types: /individuals/24/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-023_fddf4a93c1df	gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000271 RO:0002234 gomodel:YeastPathways_DETOX1-PWY/6a4c244800000272."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/22; endpoint types: /individuals/37/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-024_045bafb173d3	gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257	RO:0002234	CHEBI:16240	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257 RO:0002234 gomodel:CHEBI_16240_SUPEROX-DISMUT-RXN."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/23; endpoint types: /individuals/24/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-025_ec92334abe53	SGD:S000001050	pathwaymech:enables	gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_DETOX1-PWY/6a4c244800000257 RO:0002333 gomodel:YeastPathways_DETOX1-PWY/6a4c244800000262."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/24; endpoint types: /individuals/24/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_edge-026_152e9bca7bf6	gomodel:SUPEROX-DISMUT-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_DETOX1-PWY		"[{""reference_id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_assertion"": ""The model asserts gomodel:SUPEROX-DISMUT-RXN BFO:0000066 gomodel:reaction_SUPEROX-DISMUT-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_DETOX1-PWY.json#/facts/25; endpoint types: /individuals/8/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_DETOX1-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_DETOX1-PWY.json"", ""title"": ""GO-CAM superoxide radicals degradation model YeastPathways_DETOX1-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_location-8ef34cdb9d4a_295f8fa70333	SGD:S000003865	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00445	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11500508) Source qualification: A small percentage (around 1-5 percent) localizes to the mitochondrial intermembrane space	"[{""reference_id"": ""UniProtKB:P00445"", ""source_assertion"": ""UniProtKB:P00445 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/32/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00445"", ""source_assertion"": ""UniProtKB:P00445 has the exact SGD cross-reference SGD:S000003865."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/32/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00445"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00445 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_location-19486e8c1bc2_9923f0cf6421	SGD:S000003865	RO:0001025	GO:0005758	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00445	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11500508); ECO:0000269 (PubMed:22984289) Source qualification: A small percentage (around 1-5 percent) localizes to the mitochondrial intermembrane space	"[{""reference_id"": ""UniProtKB:P00445"", ""source_assertion"": ""UniProtKB:P00445 annotates location Mitochondrion intermembrane space (SL-0169)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/32/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00445"", ""source_assertion"": ""UniProtKB:P00445 has the exact SGD cross-reference SGD:S000003865."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/32/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00445"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00445 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_location-91328db19db7_e01cf164d829	SGD:S000002664	RO:0001025	GO:0005782	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15202	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:1986244)	"[{""reference_id"": ""UniProtKB:P15202"", ""source_assertion"": ""UniProtKB:P15202 annotates location Peroxisome matrix (SL-0202)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/408/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P15202"", ""source_assertion"": ""UniProtKB:P15202 has the exact SGD cross-reference SGD:S000002664."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/408/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P15202"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P15202 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_location-64ac878c92c3_7374dd90baeb	SGD:S000003320	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06115	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P06115"", ""source_assertion"": ""UniProtKB:P06115 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3239/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P06115"", ""source_assertion"": ""UniProtKB:P06115 has the exact SGD cross-reference SGD:S000003320."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3239/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P06115"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06115 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_location-3c9cc3c8afab_59264191bf5e	SGD:S000001050	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00447	Physical protein location from reviewed UniProt. ECO:0000250 (UniProtKB:Q9UQX0)	"[{""reference_id"": ""UniProtKB:P00447"", ""source_assertion"": ""UniProtKB:P00447 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3217/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00447"", ""source_assertion"": ""UniProtKB:P00447 has the exact SGD cross-reference SGD:S000001050."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3217/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00447"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00447 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_cofactor-b4b37f5a48fd_d23f52116782	SGD:S000003865	pathwaymech:has_cofactor	CHEBI:23378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00445	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10026301); ECO:0000269 (PubMed:36630448); ECO:0000269 (PubMed:8652572) Binds 1 copper ion per subunit. UniProt note evidence: ECO:0000269 (PubMed:10026301); ECO:0000269 (PubMed:8652572)	"[{""reference_id"": ""UniProtKB:P00445"", ""source_assertion"": ""UniProtKB:P00445 annotates CHEBI:23378 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/32/comments/0/cofactors/0; /results/32/comments/0/note""}, {""reference_id"": ""UniProtKB:P00445"", ""source_assertion"": ""UniProtKB:P00445 has the exact SGD cross-reference SGD:S000003865."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/32/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00445"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00445 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_cofactor-24d56d9c917e_3ab56fbe7e94	SGD:S000003865	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00445	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10026301); ECO:0000269 (PubMed:11524675) Binds 1 zinc ion per subunit. UniProt note evidence: ECO:0000269 (PubMed:10026301); ECO:0000269 (PubMed:11524675)	"[{""reference_id"": ""UniProtKB:P00445"", ""source_assertion"": ""UniProtKB:P00445 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/32/comments/1/cofactors/0; /results/32/comments/1/note""}, {""reference_id"": ""UniProtKB:P00445"", ""source_assertion"": ""UniProtKB:P00445 has the exact SGD cross-reference SGD:S000003865."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/32/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00445"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00445 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_cofactor-5c3c0cf6f4fa_77b6f6f07505	SGD:S000002664	pathwaymech:has_cofactor	CHEBI:30413	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15202	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:9931255)	"[{""reference_id"": ""UniProtKB:P15202"", ""source_assertion"": ""UniProtKB:P15202 annotates CHEBI:30413 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/408/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P15202"", ""source_assertion"": ""UniProtKB:P15202 has the exact SGD cross-reference SGD:S000002664."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/408/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P15202"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P15202 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_cofactor-3dd8f5fd90b4_44ee771a5f3e	SGD:S000003320	pathwaymech:has_cofactor	CHEBI:30413	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06115	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P06115"", ""source_assertion"": ""UniProtKB:P06115 annotates CHEBI:30413 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3239/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P06115"", ""source_assertion"": ""UniProtKB:P06115 has the exact SGD cross-reference SGD:S000003320."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3239/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P06115"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06115 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_DETOX1-PWY_cofactor-b8aa1e3a2c24_2041fdb09179	SGD:S000001050	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00447	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q9UQX0) Binds 1 Mn(2+) ion per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:Q9UQX0)	"[{""reference_id"": ""UniProtKB:P00447"", ""source_assertion"": ""UniProtKB:P00447 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3217/comments/0/cofactors/0; /results/3217/comments/0/note""}, {""reference_id"": ""UniProtKB:P00447"", ""source_assertion"": ""UniProtKB:P00447 has the exact SGD cross-reference SGD:S000001050."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3217/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00447"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00447 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-001_450a9859bbea	CHEBI:29748	pathwaymech:consumes	RHEA:18986	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18986		"[{""reference_id"": ""RHEA:18986"", ""source_assertion"": ""RHEA:18986 assigns CHEBI:29748 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/18986 rh:substrates http://rdf.rhea-db.org/18985_L; http://rdf.rhea-db.org/18985_L rh:contains1 http://rdf.rhea-db.org/Participant_18985_compound_3304; http://rdf.rhea-db.org/Participant_18985_compound_3304 rh:compound http://rdf.rhea-db.org/Compound_3304; http://rdf.rhea-db.org/Compound_3304 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:18986"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""chorismate => isochorismate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-002_ff9da1be2ac7	RHEA:18986	pathwaymech:produces	CHEBI:29780	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18986		"[{""reference_id"": ""RHEA:18986"", ""source_assertion"": ""RHEA:18986 assigns CHEBI:29780 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/18986 rh:products http://rdf.rhea-db.org/18985_R; http://rdf.rhea-db.org/18985_R rh:contains1 http://rdf.rhea-db.org/Participant_18985_compound_3577; http://rdf.rhea-db.org/Participant_18985_compound_3577 rh:compound http://rdf.rhea-db.org/Compound_3577; http://rdf.rhea-db.org/Compound_3577 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:18986"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""chorismate => isochorismate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-003_7ffc410833fb	CHEBI:29780	pathwaymech:consumes	RHEA:25594	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25594		"[{""reference_id"": ""RHEA:25594"", ""source_assertion"": ""RHEA:25594 assigns CHEBI:29780 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25594 rh:substrates http://rdf.rhea-db.org/25593_L; http://rdf.rhea-db.org/25593_L rh:contains1 http://rdf.rhea-db.org/Participant_25593_compound_3577; http://rdf.rhea-db.org/Participant_25593_compound_3577 rh:compound http://rdf.rhea-db.org/Compound_3577; http://rdf.rhea-db.org/Compound_3577 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:25594"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""isochorismate + 2-oxoglutarate + H(+) => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-004_384b57b6dab8	CHEBI:16810	pathwaymech:consumes	RHEA:25594	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25594		"[{""reference_id"": ""RHEA:25594"", ""source_assertion"": ""RHEA:25594 assigns CHEBI:16810 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25594 rh:substrates http://rdf.rhea-db.org/25593_L; http://rdf.rhea-db.org/25593_L rh:contains1 http://rdf.rhea-db.org/Participant_25593_compound_2975; http://rdf.rhea-db.org/Participant_25593_compound_2975 rh:compound http://rdf.rhea-db.org/Compound_2975; http://rdf.rhea-db.org/Compound_2975 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:25594"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""isochorismate + 2-oxoglutarate + H(+) => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-005_a3eb444fd616	CHEBI:15378	pathwaymech:consumes	RHEA:25594	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25594		"[{""reference_id"": ""RHEA:25594"", ""source_assertion"": ""RHEA:25594 assigns CHEBI:15378 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25594 rh:substrates http://rdf.rhea-db.org/25593_L; http://rdf.rhea-db.org/25593_L rh:contains1 http://rdf.rhea-db.org/Participant_25593_compound_3249; http://rdf.rhea-db.org/Participant_25593_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; http://rdf.rhea-db.org/Compound_3249 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:25594"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""isochorismate + 2-oxoglutarate + H(+) => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-006_a27f14b25171	RHEA:25594	pathwaymech:produces	CHEBI:58818	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25594		"[{""reference_id"": ""RHEA:25594"", ""source_assertion"": ""RHEA:25594 assigns CHEBI:58818 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25594 rh:products http://rdf.rhea-db.org/25593_R; http://rdf.rhea-db.org/25593_R rh:contains1 http://rdf.rhea-db.org/Participant_25593_compound_5683; http://rdf.rhea-db.org/Participant_25593_compound_5683 rh:compound http://rdf.rhea-db.org/Compound_5683; http://rdf.rhea-db.org/Compound_5683 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:25594"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""isochorismate + 2-oxoglutarate + H(+) => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-007_140d3959d23d	RHEA:25594	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25594		"[{""reference_id"": ""RHEA:25594"", ""source_assertion"": ""RHEA:25594 assigns CHEBI:16526 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25594 rh:products http://rdf.rhea-db.org/25593_R; http://rdf.rhea-db.org/25593_R rh:contains1 http://rdf.rhea-db.org/Participant_25593_compound_4391; http://rdf.rhea-db.org/Participant_25593_compound_4391 rh:compound http://rdf.rhea-db.org/Compound_4391; http://rdf.rhea-db.org/Compound_4391 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:25594"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""isochorismate + 2-oxoglutarate + H(+) => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-008_cc7e3233e0f7	CHEBI:58818	pathwaymech:consumes	RHEA:25598	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25598		"[{""reference_id"": ""RHEA:25598"", ""source_assertion"": ""RHEA:25598 assigns CHEBI:58818 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25598 rh:substrates http://rdf.rhea-db.org/25597_L; http://rdf.rhea-db.org/25597_L rh:contains1 http://rdf.rhea-db.org/Participant_25597_compound_5683; http://rdf.rhea-db.org/Participant_25597_compound_5683 rh:compound http://rdf.rhea-db.org/Compound_5683; http://rdf.rhea-db.org/Compound_5683 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:25598"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-009_d7f710516204	RHEA:25598	pathwaymech:produces	CHEBI:58689	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25598		"[{""reference_id"": ""RHEA:25598"", ""source_assertion"": ""RHEA:25598 assigns CHEBI:58689 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25598 rh:products http://rdf.rhea-db.org/25597_R; http://rdf.rhea-db.org/25597_R rh:contains1 http://rdf.rhea-db.org/Participant_25597_compound_5418; http://rdf.rhea-db.org/Participant_25597_compound_5418 rh:compound http://rdf.rhea-db.org/Compound_5418; http://rdf.rhea-db.org/Compound_5418 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:25598"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-010_45dc20787864	RHEA:25598	pathwaymech:produces	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25598		"[{""reference_id"": ""RHEA:25598"", ""source_assertion"": ""RHEA:25598 assigns CHEBI:15361 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/25598 rh:products http://rdf.rhea-db.org/25597_R; http://rdf.rhea-db.org/25597_R rh:contains1 http://rdf.rhea-db.org/Participant_25597_compound_3719; http://rdf.rhea-db.org/Participant_25597_compound_3719 rh:compound http://rdf.rhea-db.org/Compound_3719; http://rdf.rhea-db.org/Compound_3719 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:25598"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-011_46183689c80f	CHEBI:58689	pathwaymech:consumes	RHEA:10197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10197		"[{""reference_id"": ""RHEA:10197"", ""source_assertion"": ""RHEA:10197 assigns CHEBI:58689 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10197 rh:substrates http://rdf.rhea-db.org/10196_L; http://rdf.rhea-db.org/10196_L rh:contains1 http://rdf.rhea-db.org/Participant_10196_compound_5418; http://rdf.rhea-db.org/Participant_10196_compound_5418 rh:compound http://rdf.rhea-db.org/Compound_5418; http://rdf.rhea-db.org/Compound_5418 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:10197"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate => 2-succinylbenzoate + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-012_627c619746e4	RHEA:10197	pathwaymech:produces	CHEBI:18325	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10197		"[{""reference_id"": ""RHEA:10197"", ""source_assertion"": ""RHEA:10197 assigns CHEBI:18325 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10197 rh:products http://rdf.rhea-db.org/10196_R; http://rdf.rhea-db.org/10196_R rh:contains1 http://rdf.rhea-db.org/Participant_10196_compound_5241; http://rdf.rhea-db.org/Participant_10196_compound_5241 rh:compound http://rdf.rhea-db.org/Compound_5241; http://rdf.rhea-db.org/Compound_5241 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:10197"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate => 2-succinylbenzoate + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-013_61db4f889ef1	RHEA:10197	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10197		"[{""reference_id"": ""RHEA:10197"", ""source_assertion"": ""RHEA:10197 assigns CHEBI:15377 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/10197 rh:products http://rdf.rhea-db.org/10196_R; http://rdf.rhea-db.org/10196_R rh:contains1 http://rdf.rhea-db.org/Participant_10196_compound_1283; http://rdf.rhea-db.org/Participant_10196_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; http://rdf.rhea-db.org/Compound_1283 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:10197"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate => 2-succinylbenzoate + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-014_3823d89243ae	CHEBI:18325	pathwaymech:consumes	RHEA:17010	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17010		"[{""reference_id"": ""RHEA:17010"", ""source_assertion"": ""RHEA:17010 assigns CHEBI:18325 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17010 rh:substrates http://rdf.rhea-db.org/17009_L; http://rdf.rhea-db.org/17009_L rh:contains1 http://rdf.rhea-db.org/Participant_17009_compound_5241; http://rdf.rhea-db.org/Participant_17009_compound_5241 rh:compound http://rdf.rhea-db.org/Compound_5241; http://rdf.rhea-db.org/Compound_5241 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:17010"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-succinylbenzoate + ATP + CoA => 2-succinylbenzoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-015_2865738ce6cf	CHEBI:30616	pathwaymech:consumes	RHEA:17010	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17010		"[{""reference_id"": ""RHEA:17010"", ""source_assertion"": ""RHEA:17010 assigns CHEBI:30616 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17010 rh:substrates http://rdf.rhea-db.org/17009_L; http://rdf.rhea-db.org/17009_L rh:contains1 http://rdf.rhea-db.org/Participant_17009_compound_6372; http://rdf.rhea-db.org/Participant_17009_compound_6372 rh:compound http://rdf.rhea-db.org/Compound_6372; http://rdf.rhea-db.org/Compound_6372 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:17010"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-succinylbenzoate + ATP + CoA => 2-succinylbenzoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-016_4852563984fb	CHEBI:57287	pathwaymech:consumes	RHEA:17010	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17010		"[{""reference_id"": ""RHEA:17010"", ""source_assertion"": ""RHEA:17010 assigns CHEBI:57287 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17010 rh:substrates http://rdf.rhea-db.org/17009_L; http://rdf.rhea-db.org/17009_L rh:contains1 http://rdf.rhea-db.org/Participant_17009_compound_1264; http://rdf.rhea-db.org/Participant_17009_compound_1264 rh:compound http://rdf.rhea-db.org/Compound_1264; http://rdf.rhea-db.org/Compound_1264 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:17010"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-succinylbenzoate + ATP + CoA => 2-succinylbenzoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-017_8deabf380760	RHEA:17010	pathwaymech:produces	CHEBI:57364	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17010		"[{""reference_id"": ""RHEA:17010"", ""source_assertion"": ""RHEA:17010 assigns CHEBI:57364 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17010 rh:products http://rdf.rhea-db.org/17009_R; http://rdf.rhea-db.org/17009_R rh:contains1 http://rdf.rhea-db.org/Participant_17009_compound_2208; http://rdf.rhea-db.org/Participant_17009_compound_2208 rh:compound http://rdf.rhea-db.org/Compound_2208; http://rdf.rhea-db.org/Compound_2208 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:17010"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-succinylbenzoate + ATP + CoA => 2-succinylbenzoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-018_f5bb8f1ab3a1	RHEA:17010	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17010		"[{""reference_id"": ""RHEA:17010"", ""source_assertion"": ""RHEA:17010 assigns CHEBI:456215 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17010 rh:products http://rdf.rhea-db.org/17009_R; http://rdf.rhea-db.org/17009_R rh:contains1 http://rdf.rhea-db.org/Participant_17009_compound_2590; http://rdf.rhea-db.org/Participant_17009_compound_2590 rh:compound http://rdf.rhea-db.org/Compound_2590; http://rdf.rhea-db.org/Compound_2590 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:17010"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-succinylbenzoate + ATP + CoA => 2-succinylbenzoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-019_a28226d3c658	RHEA:17010	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17010		"[{""reference_id"": ""RHEA:17010"", ""source_assertion"": ""RHEA:17010 assigns CHEBI:33019 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17010 rh:products http://rdf.rhea-db.org/17009_R; http://rdf.rhea-db.org/17009_R rh:contains1 http://rdf.rhea-db.org/Participant_17009_compound_2106; http://rdf.rhea-db.org/Participant_17009_compound_2106 rh:compound http://rdf.rhea-db.org/Compound_2106; http://rdf.rhea-db.org/Compound_2106 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:17010"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-succinylbenzoate + ATP + CoA => 2-succinylbenzoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-020_9abebaf28695	CHEBI:57364	pathwaymech:consumes	RHEA:26563	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26563		"[{""reference_id"": ""RHEA:26563"", ""source_assertion"": ""RHEA:26563 assigns CHEBI:57364 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26563 rh:substrates http://rdf.rhea-db.org/26562_L; http://rdf.rhea-db.org/26562_L rh:contains1 http://rdf.rhea-db.org/Participant_26562_compound_2208; http://rdf.rhea-db.org/Participant_26562_compound_2208 rh:compound http://rdf.rhea-db.org/Compound_2208; http://rdf.rhea-db.org/Compound_2208 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:26563"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-succinylbenzoyl-CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-021_4780b2aae5d5	CHEBI:15378	pathwaymech:consumes	RHEA:26563	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26563		"[{""reference_id"": ""RHEA:26563"", ""source_assertion"": ""RHEA:26563 assigns CHEBI:15378 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26563 rh:substrates http://rdf.rhea-db.org/26562_L; http://rdf.rhea-db.org/26562_L rh:contains1 http://rdf.rhea-db.org/Participant_26562_compound_3249; http://rdf.rhea-db.org/Participant_26562_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; http://rdf.rhea-db.org/Compound_3249 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:26563"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-succinylbenzoyl-CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-022_c8fc3d88118d	RHEA:26563	pathwaymech:produces	CHEBI:58897	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26563		"[{""reference_id"": ""RHEA:26563"", ""source_assertion"": ""RHEA:26563 assigns CHEBI:58897 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26563 rh:products http://rdf.rhea-db.org/26562_R; http://rdf.rhea-db.org/26562_R rh:contains1 http://rdf.rhea-db.org/Participant_26562_compound_5962; http://rdf.rhea-db.org/Participant_26562_compound_5962 rh:compound http://rdf.rhea-db.org/Compound_5962; http://rdf.rhea-db.org/Compound_5962 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:26563"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-succinylbenzoyl-CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-023_b71388f20cd1	RHEA:26563	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26563		"[{""reference_id"": ""RHEA:26563"", ""source_assertion"": ""RHEA:26563 assigns CHEBI:15377 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26563 rh:products http://rdf.rhea-db.org/26562_R; http://rdf.rhea-db.org/26562_R rh:contains1 http://rdf.rhea-db.org/Participant_26562_compound_1283; http://rdf.rhea-db.org/Participant_26562_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; http://rdf.rhea-db.org/Compound_1283 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:26563"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-succinylbenzoyl-CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-024_35f28ce0b395	CHEBI:58897	pathwaymech:consumes	RHEA:26310	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26310		"[{""reference_id"": ""RHEA:26310"", ""source_assertion"": ""RHEA:26310 assigns CHEBI:58897 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26310 rh:substrates http://rdf.rhea-db.org/26309_L; http://rdf.rhea-db.org/26309_L rh:contains1 http://rdf.rhea-db.org/Participant_26309_compound_5962; http://rdf.rhea-db.org/Participant_26309_compound_5962 rh:compound http://rdf.rhea-db.org/Compound_5962; http://rdf.rhea-db.org/Compound_5962 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:26310"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""1,4-dihydroxy-2-naphthoyl-CoA + H2O => 1,4-dihydroxy-2-naphthoate + CoA + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-025_0b9c519e432c	CHEBI:15377	pathwaymech:consumes	RHEA:26310	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26310		"[{""reference_id"": ""RHEA:26310"", ""source_assertion"": ""RHEA:26310 assigns CHEBI:15377 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26310 rh:substrates http://rdf.rhea-db.org/26309_L; http://rdf.rhea-db.org/26309_L rh:contains1 http://rdf.rhea-db.org/Participant_26309_compound_1283; http://rdf.rhea-db.org/Participant_26309_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; http://rdf.rhea-db.org/Compound_1283 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:26310"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""1,4-dihydroxy-2-naphthoyl-CoA + H2O => 1,4-dihydroxy-2-naphthoate + CoA + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-026_0f2a9ba5d2cc	RHEA:26310	pathwaymech:produces	CHEBI:11173	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26310		"[{""reference_id"": ""RHEA:26310"", ""source_assertion"": ""RHEA:26310 assigns CHEBI:11173 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26310 rh:products http://rdf.rhea-db.org/26309_R; http://rdf.rhea-db.org/26309_R rh:contains1 http://rdf.rhea-db.org/Participant_26309_compound_6107; http://rdf.rhea-db.org/Participant_26309_compound_6107 rh:compound http://rdf.rhea-db.org/Compound_6107; http://rdf.rhea-db.org/Compound_6107 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:26310"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""1,4-dihydroxy-2-naphthoyl-CoA + H2O => 1,4-dihydroxy-2-naphthoate + CoA + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-027_ab0132a59de3	RHEA:26310	pathwaymech:produces	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26310		"[{""reference_id"": ""RHEA:26310"", ""source_assertion"": ""RHEA:26310 assigns CHEBI:57287 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26310 rh:products http://rdf.rhea-db.org/26309_R; http://rdf.rhea-db.org/26309_R rh:contains1 http://rdf.rhea-db.org/Participant_26309_compound_1264; http://rdf.rhea-db.org/Participant_26309_compound_1264 rh:compound http://rdf.rhea-db.org/Compound_1264; http://rdf.rhea-db.org/Compound_1264 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:26310"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""1,4-dihydroxy-2-naphthoyl-CoA + H2O => 1,4-dihydroxy-2-naphthoate + CoA + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-028_468edad13116	RHEA:26310	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26310		"[{""reference_id"": ""RHEA:26310"", ""source_assertion"": ""RHEA:26310 assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26310 rh:products http://rdf.rhea-db.org/26309_R; http://rdf.rhea-db.org/26309_R rh:contains1 http://rdf.rhea-db.org/Participant_26309_compound_3249; http://rdf.rhea-db.org/Participant_26309_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; http://rdf.rhea-db.org/Compound_3249 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:26310"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""1,4-dihydroxy-2-naphthoyl-CoA + H2O => 1,4-dihydroxy-2-naphthoate + CoA + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-029_8c730a0b0a28	CHEBI:128769	pathwaymech:consumes	RHEA:27799	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27799		"[{""reference_id"": ""RHEA:27799"", ""source_assertion"": ""RHEA:27799 assigns CHEBI:128769 to its substrates with coefficient 5."", ""source_locator"": ""http://rdf.rhea-db.org/27799 rh:substrates http://rdf.rhea-db.org/27798_L; http://rdf.rhea-db.org/27798_L rh:contains5 http://rdf.rhea-db.org/Participant_27798_compound_4425; http://rdf.rhea-db.org/Participant_27798_compound_4425 rh:compound http://rdf.rhea-db.org/Compound_4425; http://rdf.rhea-db.org/Compound_4425 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:27799"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""5 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate => all-trans-octaprenyl diphosphate + 5 diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-030_2e2d16acbcd7	CHEBI:175763	pathwaymech:consumes	RHEA:27799	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27799		"[{""reference_id"": ""RHEA:27799"", ""source_assertion"": ""RHEA:27799 assigns CHEBI:175763 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/27799 rh:substrates http://rdf.rhea-db.org/27798_L; http://rdf.rhea-db.org/27798_L rh:contains1 http://rdf.rhea-db.org/Participant_27798_compound_1582; http://rdf.rhea-db.org/Participant_27798_compound_1582 rh:compound http://rdf.rhea-db.org/Compound_1582; http://rdf.rhea-db.org/Compound_1582 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:27799"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""5 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate => all-trans-octaprenyl diphosphate + 5 diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-031_ca712c38ff69	RHEA:27799	pathwaymech:produces	CHEBI:57711	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27799		"[{""reference_id"": ""RHEA:27799"", ""source_assertion"": ""RHEA:27799 assigns CHEBI:57711 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/27799 rh:products http://rdf.rhea-db.org/27798_R; http://rdf.rhea-db.org/27798_R rh:contains1 http://rdf.rhea-db.org/Participant_27798_compound_1744; http://rdf.rhea-db.org/Participant_27798_compound_1744 rh:compound http://rdf.rhea-db.org/Compound_1744; http://rdf.rhea-db.org/Compound_1744 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:27799"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""5 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate => all-trans-octaprenyl diphosphate + 5 diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-032_23ac51f23aa3	RHEA:27799	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27799		"[{""reference_id"": ""RHEA:27799"", ""source_assertion"": ""RHEA:27799 assigns CHEBI:33019 to its products with coefficient 5."", ""source_locator"": ""http://rdf.rhea-db.org/27799 rh:products http://rdf.rhea-db.org/27798_R; http://rdf.rhea-db.org/27798_R rh:contains5 http://rdf.rhea-db.org/Participant_27798_compound_2106; http://rdf.rhea-db.org/Participant_27798_compound_2106 rh:compound http://rdf.rhea-db.org/Compound_2106; http://rdf.rhea-db.org/Compound_2106 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:27799"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""5 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate => all-trans-octaprenyl diphosphate + 5 diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-033_8dcb87336782	CHEBI:57711	pathwaymech:consumes	RHEA:30100	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30100		"[{""reference_id"": ""RHEA:30100"", ""source_assertion"": ""RHEA:30100 assigns CHEBI:57711 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30100 rh:substrates http://rdf.rhea-db.org/30099_L; http://rdf.rhea-db.org/30099_L rh:contains1 http://rdf.rhea-db.org/Participant_30099_compound_1744; http://rdf.rhea-db.org/Participant_30099_compound_1744 rh:compound http://rdf.rhea-db.org/Compound_1744; http://rdf.rhea-db.org/Compound_1744 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:30100"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""all-trans-octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-034_4be673d8e3ce	CHEBI:11173	pathwaymech:consumes	RHEA:30100	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30100		"[{""reference_id"": ""RHEA:30100"", ""source_assertion"": ""RHEA:30100 assigns CHEBI:11173 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30100 rh:substrates http://rdf.rhea-db.org/30099_L; http://rdf.rhea-db.org/30099_L rh:contains1 http://rdf.rhea-db.org/Participant_30099_compound_6107; http://rdf.rhea-db.org/Participant_30099_compound_6107 rh:compound http://rdf.rhea-db.org/Compound_6107; http://rdf.rhea-db.org/Compound_6107 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:30100"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""all-trans-octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-035_3027792dc2aa	CHEBI:15378	pathwaymech:consumes	RHEA:30100	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30100		"[{""reference_id"": ""RHEA:30100"", ""source_assertion"": ""RHEA:30100 assigns CHEBI:15378 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30100 rh:substrates http://rdf.rhea-db.org/30099_L; http://rdf.rhea-db.org/30099_L rh:contains1 http://rdf.rhea-db.org/Participant_30099_compound_3249; http://rdf.rhea-db.org/Participant_30099_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; http://rdf.rhea-db.org/Compound_3249 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:30100"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""all-trans-octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-036_e8a233878cb4	RHEA:30100	pathwaymech:produces	CHEBI:61873	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30100		"[{""reference_id"": ""RHEA:30100"", ""source_assertion"": ""RHEA:30100 assigns CHEBI:61873 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30100 rh:products http://rdf.rhea-db.org/30099_R; http://rdf.rhea-db.org/30099_R rh:contains1 http://rdf.rhea-db.org/Participant_30099_compound_6609; http://rdf.rhea-db.org/Participant_30099_compound_6609 rh:compound http://rdf.rhea-db.org/Compound_6609; http://rdf.rhea-db.org/Compound_6609 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:30100"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""all-trans-octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-037_1c3ef2e5cc80	RHEA:30100	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30100		"[{""reference_id"": ""RHEA:30100"", ""source_assertion"": ""RHEA:30100 assigns CHEBI:16526 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30100 rh:products http://rdf.rhea-db.org/30099_R; http://rdf.rhea-db.org/30099_R rh:contains1 http://rdf.rhea-db.org/Participant_30099_compound_4391; http://rdf.rhea-db.org/Participant_30099_compound_4391 rh:compound http://rdf.rhea-db.org/Compound_4391; http://rdf.rhea-db.org/Compound_4391 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:30100"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""all-trans-octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-038_f2b1eda74e8b	RHEA:30100	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30100		"[{""reference_id"": ""RHEA:30100"", ""source_assertion"": ""RHEA:30100 assigns CHEBI:33019 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30100 rh:products http://rdf.rhea-db.org/30099_R; http://rdf.rhea-db.org/30099_R rh:contains1 http://rdf.rhea-db.org/Participant_30099_compound_2106; http://rdf.rhea-db.org/Participant_30099_compound_2106 rh:compound http://rdf.rhea-db.org/Compound_2106; http://rdf.rhea-db.org/Compound_2106 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:30100"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""all-trans-octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-039_cc9af907503c	CHEBI:61873	pathwaymech:consumes	RHEA:30064	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30064		"[{""reference_id"": ""RHEA:30064"", ""source_assertion"": ""RHEA:30064 assigns CHEBI:61873 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30064 rh:substrates http://rdf.rhea-db.org/30063_L; http://rdf.rhea-db.org/30063_L rh:contains1 http://rdf.rhea-db.org/Participant_30063_compound_6609; http://rdf.rhea-db.org/Participant_30063_compound_6609 rh:compound http://rdf.rhea-db.org/Compound_6609; http://rdf.rhea-db.org/Compound_6609 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:30064"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-demethylmenaquinol-8 + S-adenosyl-L-methionine => menaquinol-8 + S-adenosyl-L-homocysteine + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-040_5fdd2918143c	CHEBI:59789	pathwaymech:consumes	RHEA:30064	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30064		"[{""reference_id"": ""RHEA:30064"", ""source_assertion"": ""RHEA:30064 assigns CHEBI:59789 to its substrates with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30064 rh:substrates http://rdf.rhea-db.org/30063_L; http://rdf.rhea-db.org/30063_L rh:contains1 http://rdf.rhea-db.org/Participant_30063_compound_6127; http://rdf.rhea-db.org/Participant_30063_compound_6127 rh:compound http://rdf.rhea-db.org/Compound_6127; http://rdf.rhea-db.org/Compound_6127 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:30064"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-demethylmenaquinol-8 + S-adenosyl-L-methionine => menaquinol-8 + S-adenosyl-L-homocysteine + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-041_804b1acdbffd	RHEA:30064	pathwaymech:produces	CHEBI:61684	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30064		"[{""reference_id"": ""RHEA:30064"", ""source_assertion"": ""RHEA:30064 assigns CHEBI:61684 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30064 rh:products http://rdf.rhea-db.org/30063_R; http://rdf.rhea-db.org/30063_R rh:contains1 http://rdf.rhea-db.org/Participant_30063_compound_6557; http://rdf.rhea-db.org/Participant_30063_compound_6557 rh:compound http://rdf.rhea-db.org/Compound_6557; http://rdf.rhea-db.org/Compound_6557 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:30064"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-demethylmenaquinol-8 + S-adenosyl-L-methionine => menaquinol-8 + S-adenosyl-L-homocysteine + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-042_eb084c22dc34	RHEA:30064	pathwaymech:produces	CHEBI:57856	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30064		"[{""reference_id"": ""RHEA:30064"", ""source_assertion"": ""RHEA:30064 assigns CHEBI:57856 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30064 rh:products http://rdf.rhea-db.org/30063_R; http://rdf.rhea-db.org/30063_R rh:contains1 http://rdf.rhea-db.org/Participant_30063_compound_4281; http://rdf.rhea-db.org/Participant_30063_compound_4281 rh:compound http://rdf.rhea-db.org/Compound_4281; http://rdf.rhea-db.org/Compound_4281 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:30064"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-demethylmenaquinol-8 + S-adenosyl-L-methionine => menaquinol-8 + S-adenosyl-L-homocysteine + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-043_dbc422285076	RHEA:30064	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30064		"[{""reference_id"": ""RHEA:30064"", ""source_assertion"": ""RHEA:30064 assigns CHEBI:15378 to its products with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/30064 rh:products http://rdf.rhea-db.org/30063_R; http://rdf.rhea-db.org/30063_R rh:contains1 http://rdf.rhea-db.org/Participant_30063_compound_3249; http://rdf.rhea-db.org/Participant_30063_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; http://rdf.rhea-db.org/Compound_3249 rh:accession; rh:chebi""}]"	"[{""id"": ""RHEA:30064"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-demethylmenaquinol-8 + S-adenosyl-L-methionine => menaquinol-8 + S-adenosyl-L-homocysteine + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-044_7bfeaac0e2f0	MetaCyc:MENF-CPLX	pathwaymech:catalyzes	RHEA:18986	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:MENF-CPLX|PMID:9150206|PMID:9795253|RHEA:18986|UniProtKB:P38051		"[{""reference_id"": ""UniProtKB:P38051"", ""source_assertion"": ""The reviewed K-12 entry assigns this catalytic function with ECO:0000255 HAMAP-Rule:MF_01935, ECO:0000269 PubMed:17240978, ECO:0000269 PubMed:8764478, ECO:0000269 PubMed:9150206, ECO:0000269 PubMed:9795253. Its Rhea reaction is RHEA:18985."", ""source_locator"": ""/organism/taxonId; /comments/1/reaction/name; /comments/1/reaction/reactionCrossReferences; /comments/1/reaction/evidences""}, {""reference_id"": ""RHEA:18986"", ""source_assertion"": ""RHEA:18985 explicitly links the left-to-right directional reaction RHEA:18986."", ""source_locator"": ""http://rdf.rhea-db.org/18985 rh:directionalReaction http://rdf.rhea-db.org/18986; http://rdf.rhea-db.org/18986 rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""MetaCyc:MENF-CPLX"", ""source_assertion"": ""Native MENF-CPLX explicitly links its catalyzed enzymatic reaction to ISOCHORSYN-RXN; this supports the reaction assignment."", ""source_locator"": ""Protein[@frameid=\""MENF-CPLX\""]/catalyzes/Enzymatic-Reaction/reaction/Reaction/@frameid""}, {""reference_id"": ""PMID:9150206"", ""source_assertion"": ""Purified recombinant E. coli MenF converts chorismate to isochorismate with magnesium; gel filtration and SDS-PAGE support a homodimer. The abstract described the reaction as irreversible, whereas the later MenF/EntC study found reversibility."", ""source_locator"": ""/resultList/result[id=\""9150206\""]/abstractText""}, {""reference_id"": ""PMID:9795253"", ""source_assertion"": ""The primary abstract distinguishes MenF and EntC using E. coli mutants: menF disruption leaves only trace MK-8 despite intact entC. Purified tagged MenF catalyzes both forward and reverse isomerization."", ""source_locator"": ""/resultList/result[id=\""9795253\""]/abstractText""}]"	"[{""id"": ""MetaCyc:MENF-CPLX"", ""source_sha256"": ""1fc51c71488e3d5faef1ce08d921fed16b39bc012e9647f06254839c8e61aa0b"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native MENF-CPLX identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MENF-CPLX""}, {""id"": ""PMID:9150206"", ""source_sha256"": ""88e67c3c142a44ca8eb07df2d17081749cfa83a0739157a488ffd07f305c23bb"", ""source_version"": ""Europe PMC indexed primary abstract inspected; full text not claimed; retrieved 2026-10-11 UTC"", ""title"": ""Menaquinone (vitamin K2) biosynthesis: overexpression, purification, and characterization of a new isochorismate synthase from Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A9150206+OR+EXT_ID%3A9795253+OR+EXT_ID%3A17760421+OR+EXT_ID%3A18284213+OR+EXT_ID%3A20643650+OR+EXT_ID%3A23564174+OR+EXT_ID%3A24992697+OR+EXT_ID%3A25010423+OR+EXT_ID%3A9573170+OR+EXT_ID%3A9045837+OR+EXT_ID%3A8037730+OR+EXT_ID%3A30912442+OR+EXT_ID%3A39422507+OR+EXT_ID%3A10978150+OR+EXT_ID%3A8764478+OR+EXT_ID%3A26394156+OR+EXT_ID%3A14621995&format=json&resultType=core&pageSize=100""}, {""id"": ""PMID:9795253"", ""source_sha256"": ""88e67c3c142a44ca8eb07df2d17081749cfa83a0739157a488ffd07f305c23bb"", ""source_version"": ""Europe PMC indexed primary abstract inspected; full text not claimed; retrieved 2026-10-11 UTC"", ""title"": ""The role of isochorismate hydroxymutase genes entC and menF in enterobactin and menaquinone biosynthesis in Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A9150206+OR+EXT_ID%3A9795253+OR+EXT_ID%3A17760421+OR+EXT_ID%3A18284213+OR+EXT_ID%3A20643650+OR+EXT_ID%3A23564174+OR+EXT_ID%3A24992697+OR+EXT_ID%3A25010423+OR+EXT_ID%3A9573170+OR+EXT_ID%3A9045837+OR+EXT_ID%3A8037730+OR+EXT_ID%3A30912442+OR+EXT_ID%3A39422507+OR+EXT_ID%3A10978150+OR+EXT_ID%3A8764478+OR+EXT_ID%3A26394156+OR+EXT_ID%3A14621995&format=json&resultType=core&pageSize=100""}, {""id"": ""RHEA:18986"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""chorismate => isochorismate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P38051"", ""source_sha256"": ""d2a99841bbe4e93cfc8e0089e1e84f489e11820dd69c4186b2ba058781fff39c"", ""source_version"": ""UniProt entry version 191, sequence version 4; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 Isochorismate synthase MenF"", ""url"": ""https://rest.uniprot.org/uniprotkb/P38051.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-045_2db34508d06f	UniProtKB:P38051	BFO:0000050	MetaCyc:MENF-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:MENF-CPLX|MetaCyc:MENF-MONOMER|UniProtKB:P38051		"[{""reference_id"": ""MetaCyc:MENF-CPLX"", ""source_assertion"": ""The native MG1655 complex has 2 copies of MENF-MONOMER."", ""source_locator"": ""Protein[@frameid=\""MENF-CPLX\""]/component/Protein/@frameid; component/coefficient; species/Organism/@frameid""}, {""reference_id"": ""MetaCyc:MENF-MONOMER"", ""source_assertion"": ""The native protein explicitly unifies with UniProt P38051."", ""source_locator"": ""Protein[@frameid=\""MENF-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid; dblink-relationship""}, {""reference_id"": ""UniProtKB:P38051"", ""source_assertion"": ""SUBUNIT states Homodimer; its evidence codes remain explicit in the original reviewed entry."", ""source_locator"": ""/comments/6/texts""}]"	"[{""id"": ""MetaCyc:MENF-CPLX"", ""source_sha256"": ""1fc51c71488e3d5faef1ce08d921fed16b39bc012e9647f06254839c8e61aa0b"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native MENF-CPLX identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MENF-CPLX""}, {""id"": ""MetaCyc:MENF-MONOMER"", ""source_sha256"": ""d86bf7ffdc10125369c28ee52cf55373377f6b1152fa9e8434ffb42249c63027"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native MENF-MONOMER identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MENF-MONOMER""}, {""id"": ""UniProtKB:P38051"", ""source_sha256"": ""d2a99841bbe4e93cfc8e0089e1e84f489e11820dd69c4186b2ba058781fff39c"", ""source_version"": ""UniProt entry version 191, sequence version 4; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 Isochorismate synthase MenF"", ""url"": ""https://rest.uniprot.org/uniprotkb/P38051.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-046_891145db6480	MetaCyc:MENF-CPLX	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38051		"[{""reference_id"": ""UniProtKB:P38051"", ""source_assertion"": ""The reviewed entry specifies CHEBI:18420 with ECO:0000255 HAMAP-Rule:MF_01935, ECO:0000269 PubMed:17240978, ECO:0000269 PubMed:18453696, ECO:0000269 PubMed:9150206, ECO:0000269 PubMed:9795253. Binds more tightly in the presence of chorismate."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}]"	"[{""id"": ""UniProtKB:P38051"", ""source_sha256"": ""d2a99841bbe4e93cfc8e0089e1e84f489e11820dd69c4186b2ba058781fff39c"", ""source_version"": ""UniProt entry version 191, sequence version 4; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 Isochorismate synthase MenF"", ""url"": ""https://rest.uniprot.org/uniprotkb/P38051.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-047_9bcb034405f4	RHEA:18986	BFO:0000050	MetaCyc:PWY-5838	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ISOCHORSYN-RXN|MetaCyc:PWY-5837|MetaCyc:PWY-5838|PMID:23564174|RHEA:18986|UniProtKB:P38051		"[{""reference_id"": ""MetaCyc:PWY-5838"", ""source_assertion"": ""The complete superpathway explicitly includes PWY-5837 as a pathway member."", ""source_locator"": ""Pathway[@frameid=\""PWY-5838\""]/reaction-list/Pathway/@frameid""}, {""reference_id"": ""MetaCyc:PWY-5837"", ""source_assertion"": ""The full native subpathway includes ISOCHORSYN-RXN and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-5837\""]/reaction-list/Reaction/@frameid; reaction-layout[Reaction/@frameid=\""ISOCHORSYN-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:ISOCHORSYN-RXN"", ""source_assertion"": ""The native reaction explicitly cross-references RHEA:18988."", ""source_locator"": ""Reaction[@frameid=\""ISOCHORSYN-RXN\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:18986"", ""source_assertion"": ""RHEA:18985 links native cited member RHEA:18988 and selected left-to-right member RHEA:18986."", ""source_locator"": ""http://rdf.rhea-db.org/18985 rh:bidirectionalReaction http://rdf.rhea-db.org/18988; http://rdf.rhea-db.org/18985 rh:directionalReaction http://rdf.rhea-db.org/18986; http://rdf.rhea-db.org/18986 rh:substrates; rh:products""}, {""reference_id"": ""MetaCyc:PWY-5838"", ""source_assertion"": ""The native superpathway species list includes MG1655, a K-12 substrain."", ""source_locator"": ""Pathway[@frameid=\""PWY-5838\""]/species/Organism[@frameid=\""TAX-511145\""]""}, {""reference_id"": ""UniProtKB:P38051"", ""source_assertion"": ""The chosen reviewed protein entry is taxon 83333 (E. coli K-12). Other selected reviewed proteins share this taxon."", ""source_locator"": ""/organism/taxonId; /organism/scientificName""}, {""reference_id"": ""PMID:23564174"", ""source_assertion"": ""The study uses MG1655 genes for recombinant thioesterase work and BW25113-derived deletions for quinone measurements; this is specific experimental support within K-12, not evidence for identical flux in every derivative."", ""source_locator"": ""Materials and Methods, Expression and purification of proteins (#sec4); Results and Discussion, Effect of the ydiI knockout on production of menaquinone (#sec11).""}]"	"[{""id"": ""MetaCyc:ISOCHORSYN-RXN"", ""source_sha256"": ""12b0f7a51414fd2dc6ea14d9596d9cc7f0fcc121d0843c434e3ae5b23af90198"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native ISOCHORSYN-RXN identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ISOCHORSYN-RXN""}, {""id"": ""MetaCyc:PWY-5837"", ""source_sha256"": ""050bddf5109020329f96873d77e3dda7c99b1deea8bae9de800877541c2ba8c5"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5837 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5837""}, {""id"": ""MetaCyc:PWY-5838"", ""source_sha256"": ""d64dee995187648e7d1be403e38ef9824e68a729c1264d23af32f575973b78b8"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5838 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5838""}, {""id"": ""PMID:23564174"", ""source_sha256"": ""44af8e69c22e4cca4b7bb80de3064852d7a3d5d03408072bab08875248a6861d"", ""source_version"": ""Primary article body inspected; retrieved 2026-10-11 UTC"", ""title"": ""Identification of a hotdog fold thioesterase involved in the biosynthesis of menaquinone in Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3697248/""}, {""id"": ""RHEA:18986"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""chorismate => isochorismate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P38051"", ""source_sha256"": ""d2a99841bbe4e93cfc8e0089e1e84f489e11820dd69c4186b2ba058781fff39c"", ""source_version"": ""UniProt entry version 191, sequence version 4; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 Isochorismate synthase MenF"", ""url"": ""https://rest.uniprot.org/uniprotkb/P38051.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-048_270a0caa9aa9	MetaCyc:CPLX0-7525	pathwaymech:catalyzes	RHEA:25594	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7525|PMID:17760421|RHEA:25594|UniProtKB:P17109		"[{""reference_id"": ""UniProtKB:P17109"", ""source_assertion"": ""The reviewed K-12 entry assigns this catalytic function with ECO:0000255 HAMAP-Rule:MF_01659, ECO:0000269 PubMed:17760421. Its Rhea reaction is RHEA:25593."", ""source_locator"": ""/organism/taxonId; /comments/1/reaction/name; /comments/1/reaction/reactionCrossReferences; /comments/1/reaction/evidences""}, {""reference_id"": ""RHEA:25594"", ""source_assertion"": ""RHEA:25593 explicitly links the left-to-right directional reaction RHEA:25594."", ""source_locator"": ""http://rdf.rhea-db.org/25593 rh:directionalReaction http://rdf.rhea-db.org/25594; http://rdf.rhea-db.org/25594 rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""MetaCyc:CPLX0-7525"", ""source_assertion"": ""Native CPLX0-7525 explicitly links its catalyzed enzymatic reaction to 2.5.1.64-RXN; this supports the reaction assignment."", ""source_locator"": ""Protein[@frameid=\""CPLX0-7525\""]/catalyzes/Enzymatic-Reaction/reaction/Reaction/@frameid""}, {""reference_id"": ""PMID:17760421"", ""source_assertion"": ""The primary abstract identifies SEPHCHC as the actual E. coli MenD product and distinguishes subsequent pH-dependent spontaneous SHCHC formation from the enzyme reaction."", ""source_locator"": ""/resultList/result[id=\""17760421\""]/abstractText""}]"	"[{""id"": ""MetaCyc:CPLX0-7525"", ""source_sha256"": ""5b4944f168cdf982ad5aa47ca6c043e7094659273418217c20ef75234be28b41"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native CPLX0-7525 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7525""}, {""id"": ""PMID:17760421"", ""source_sha256"": ""88e67c3c142a44ca8eb07df2d17081749cfa83a0739157a488ffd07f305c23bb"", ""source_version"": ""Europe PMC indexed primary abstract inspected; full text not claimed; retrieved 2026-10-11 UTC"", ""title"": ""Menaquinone biosynthesis in Escherichia coli: identification of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate as a novel intermediate and re-evaluation of MenD activity."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A9150206+OR+EXT_ID%3A9795253+OR+EXT_ID%3A17760421+OR+EXT_ID%3A18284213+OR+EXT_ID%3A20643650+OR+EXT_ID%3A23564174+OR+EXT_ID%3A24992697+OR+EXT_ID%3A25010423+OR+EXT_ID%3A9573170+OR+EXT_ID%3A9045837+OR+EXT_ID%3A8037730+OR+EXT_ID%3A30912442+OR+EXT_ID%3A39422507+OR+EXT_ID%3A10978150+OR+EXT_ID%3A8764478+OR+EXT_ID%3A26394156+OR+EXT_ID%3A14621995&format=json&resultType=core&pageSize=100""}, {""id"": ""RHEA:25594"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""isochorismate + 2-oxoglutarate + H(+) => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P17109"", ""source_sha256"": ""a02406319564da0ea256fa19e90d3ad0e7db04c99b7a71c25ecc8c3d4ceaad5e"", ""source_version"": ""UniProt entry version 191, sequence version 4; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P17109.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-049_c7ca991a6c88	UniProtKB:P17109	BFO:0000050	MetaCyc:CPLX0-7525	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7525|MetaCyc:MEND-MONOMER|UniProtKB:P17109		"[{""reference_id"": ""MetaCyc:CPLX0-7525"", ""source_assertion"": ""The native MG1655 complex has 2 copies of MEND-MONOMER."", ""source_locator"": ""Protein[@frameid=\""CPLX0-7525\""]/component/Protein/@frameid; component/coefficient; species/Organism/@frameid""}, {""reference_id"": ""MetaCyc:MEND-MONOMER"", ""source_assertion"": ""The native protein explicitly unifies with UniProt P17109."", ""source_locator"": ""Protein[@frameid=\""MEND-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid; dblink-relationship""}, {""reference_id"": ""UniProtKB:P17109"", ""source_assertion"": ""SUBUNIT states Homodimer; its evidence codes remain explicit in the original reviewed entry."", ""source_locator"": ""/comments/7/texts""}]"	"[{""id"": ""MetaCyc:CPLX0-7525"", ""source_sha256"": ""5b4944f168cdf982ad5aa47ca6c043e7094659273418217c20ef75234be28b41"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native CPLX0-7525 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7525""}, {""id"": ""MetaCyc:MEND-MONOMER"", ""source_sha256"": ""c78fbbe203d99c9251828081cb7bfb519a43df4c8272c68c6a335a35a53fef31"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native MEND-MONOMER identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MEND-MONOMER""}, {""id"": ""UniProtKB:P17109"", ""source_sha256"": ""a02406319564da0ea256fa19e90d3ad0e7db04c99b7a71c25ecc8c3d4ceaad5e"", ""source_version"": ""UniProt entry version 191, sequence version 4; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P17109.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-050_f6956ec450b1	MetaCyc:CPLX0-7525	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P17109	Metal alternatives do not imply simultaneous magnesium and manganese occupancy.	"[{""reference_id"": ""UniProtKB:P17109"", ""source_assertion"": ""The reviewed entry specifies CHEBI:18420 with ECO:0000255 HAMAP-Rule:MF_01659."", ""source_locator"": ""/comments/2/cofactors""}]"	"[{""id"": ""UniProtKB:P17109"", ""source_sha256"": ""a02406319564da0ea256fa19e90d3ad0e7db04c99b7a71c25ecc8c3d4ceaad5e"", ""source_version"": ""UniProt entry version 191, sequence version 4; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P17109.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-051_01582fc5d413	MetaCyc:CPLX0-7525	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:14621995|UniProtKB:P17109	Metal alternatives do not imply simultaneous magnesium and manganese occupancy.	"[{""reference_id"": ""UniProtKB:P17109"", ""source_assertion"": ""The reviewed entry specifies CHEBI:29035 with ECO:0000255 HAMAP-Rule:MF_01659."", ""source_locator"": ""/comments/2/cofactors""}, {""reference_id"": ""PMID:14621995"", ""source_assertion"": ""The primary abstract describes a dimeric thiamine-diphosphate-dependent E. coli MenD that prefers manganese. Its obsolete SHCHC product assignment is not adopted."", ""source_locator"": ""/resultList/result[id=\""14621995\""]/abstractText""}]"	"[{""id"": ""PMID:14621995"", ""source_sha256"": ""88e67c3c142a44ca8eb07df2d17081749cfa83a0739157a488ffd07f305c23bb"", ""source_version"": ""Europe PMC indexed primary abstract inspected; full text not claimed; retrieved 2026-10-11 UTC"", ""title"": ""Steady-state kinetics and molecular evolution of Escherichia coli MenD [(1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase], an anomalous thiamin diphosphate-dependent decarboxylase-carboligase."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A9150206+OR+EXT_ID%3A9795253+OR+EXT_ID%3A17760421+OR+EXT_ID%3A18284213+OR+EXT_ID%3A20643650+OR+EXT_ID%3A23564174+OR+EXT_ID%3A24992697+OR+EXT_ID%3A25010423+OR+EXT_ID%3A9573170+OR+EXT_ID%3A9045837+OR+EXT_ID%3A8037730+OR+EXT_ID%3A30912442+OR+EXT_ID%3A39422507+OR+EXT_ID%3A10978150+OR+EXT_ID%3A8764478+OR+EXT_ID%3A26394156+OR+EXT_ID%3A14621995&format=json&resultType=core&pageSize=100""}, {""id"": ""UniProtKB:P17109"", ""source_sha256"": ""a02406319564da0ea256fa19e90d3ad0e7db04c99b7a71c25ecc8c3d4ceaad5e"", ""source_version"": ""UniProt entry version 191, sequence version 4; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P17109.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-052_2c8c7957ff03	MetaCyc:CPLX0-7525	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:14621995|UniProtKB:P17109		"[{""reference_id"": ""UniProtKB:P17109"", ""source_assertion"": ""The reviewed entry specifies CHEBI:58937 with ECO:0000255 HAMAP-Rule:MF_01659. Binds 1 thiamine pyrophosphate per subunit."", ""source_locator"": ""/comments/3/cofactors; /comments/3/note""}, {""reference_id"": ""PMID:14621995"", ""source_assertion"": ""The primary abstract describes a dimeric thiamine-diphosphate-dependent E. coli MenD that prefers manganese. Its obsolete SHCHC product assignment is not adopted."", ""source_locator"": ""/resultList/result[id=\""14621995\""]/abstractText""}]"	"[{""id"": ""PMID:14621995"", ""source_sha256"": ""88e67c3c142a44ca8eb07df2d17081749cfa83a0739157a488ffd07f305c23bb"", ""source_version"": ""Europe PMC indexed primary abstract inspected; full text not claimed; retrieved 2026-10-11 UTC"", ""title"": ""Steady-state kinetics and molecular evolution of Escherichia coli MenD [(1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase], an anomalous thiamin diphosphate-dependent decarboxylase-carboligase."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A9150206+OR+EXT_ID%3A9795253+OR+EXT_ID%3A17760421+OR+EXT_ID%3A18284213+OR+EXT_ID%3A20643650+OR+EXT_ID%3A23564174+OR+EXT_ID%3A24992697+OR+EXT_ID%3A25010423+OR+EXT_ID%3A9573170+OR+EXT_ID%3A9045837+OR+EXT_ID%3A8037730+OR+EXT_ID%3A30912442+OR+EXT_ID%3A39422507+OR+EXT_ID%3A10978150+OR+EXT_ID%3A8764478+OR+EXT_ID%3A26394156+OR+EXT_ID%3A14621995&format=json&resultType=core&pageSize=100""}, {""id"": ""UniProtKB:P17109"", ""source_sha256"": ""a02406319564da0ea256fa19e90d3ad0e7db04c99b7a71c25ecc8c3d4ceaad5e"", ""source_version"": ""UniProt entry version 191, sequence version 4; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P17109.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-053_be16c99776a9	RHEA:25594	BFO:0000050	MetaCyc:PWY-5838	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:2.5.1.64-RXN|MetaCyc:PWY-5837|MetaCyc:PWY-5838|RHEA:25594		"[{""reference_id"": ""MetaCyc:PWY-5838"", ""source_assertion"": ""The complete superpathway explicitly includes PWY-5837 as a pathway member."", ""source_locator"": ""Pathway[@frameid=\""PWY-5838\""]/reaction-list/Pathway/@frameid""}, {""reference_id"": ""MetaCyc:PWY-5837"", ""source_assertion"": ""The full native subpathway includes 2.5.1.64-RXN and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-5837\""]/reaction-list/Reaction/@frameid; reaction-layout[Reaction/@frameid=\""2.5.1.64-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:2.5.1.64-RXN"", ""source_assertion"": ""The native reaction explicitly cross-references RHEA:25594."", ""source_locator"": ""Reaction[@frameid=\""2.5.1.64-RXN\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:25594"", ""source_assertion"": ""RHEA:25593 explicitly links the left-to-right directional reaction RHEA:25594."", ""source_locator"": ""http://rdf.rhea-db.org/25593 rh:directionalReaction http://rdf.rhea-db.org/25594; http://rdf.rhea-db.org/25594 rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""MetaCyc:2.5.1.64-RXN"", ""source_sha256"": ""a36d2bbe71a56a2675a8bb8d9371ac356e50d5ffecf3f983b522aeee63c65800"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native 2.5.1.64-RXN identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:2.5.1.64-RXN""}, {""id"": ""MetaCyc:PWY-5837"", ""source_sha256"": ""050bddf5109020329f96873d77e3dda7c99b1deea8bae9de800877541c2ba8c5"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5837 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5837""}, {""id"": ""MetaCyc:PWY-5838"", ""source_sha256"": ""d64dee995187648e7d1be403e38ef9824e68a729c1264d23af32f575973b78b8"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5838 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5838""}, {""id"": ""RHEA:25594"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""isochorismate + 2-oxoglutarate + H(+) => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-054_1175cafeefe8	UniProtKB:P37355	pathwaymech:catalyzes	RHEA:25598	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:EG12438-MONOMER|PMID:18284213|PMID:23637813|RHEA:25598|UniProtKB:P37355	Monomeric MenH catalyzes the SHCHC-forming elimination; it is not assigned the later DHNA-CoA hydrolysis.	"[{""reference_id"": ""UniProtKB:P37355"", ""source_assertion"": ""The reviewed K-12 entry assigns this catalytic function with ECO:0000255 HAMAP-Rule:MF_01660, ECO:0000269 PubMed:18284213. Its Rhea reaction is RHEA:25597."", ""source_locator"": ""/organism/taxonId; /comments/1/reaction/name; /comments/1/reaction/reactionCrossReferences; /comments/1/reaction/evidences""}, {""reference_id"": ""RHEA:25598"", ""source_assertion"": ""RHEA:25597 explicitly links the left-to-right directional reaction RHEA:25598."", ""source_locator"": ""http://rdf.rhea-db.org/25597 rh:directionalReaction http://rdf.rhea-db.org/25598; http://rdf.rhea-db.org/25598 rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""MetaCyc:EG12438-MONOMER"", ""source_assertion"": ""Native EG12438-MONOMER explicitly links its catalyzed enzymatic reaction to RXN-9310; this supports the reaction assignment."", ""source_locator"": ""Protein[@frameid=\""EG12438-MONOMER\""]/catalyzes/Enzymatic-Reaction/reaction/Reaction/@frameid""}, {""reference_id"": ""PMID:18284213"", ""source_assertion"": ""The primary abstract identifies E. coli MenH as SHCHC synthase, catalyzing 2,5-elimination of pyruvate from SEPHCHC; it rejects the former thioesterase assignment."", ""source_locator"": ""/resultList/result[id=\""18284213\""]/abstractText""}, {""reference_id"": ""PMID:23637813"", ""source_assertion"": ""Purified tagged EcMenH elutes as a monomer by size exclusion; dynamic light scattering and crystal-interface analysis support monomeric solution behavior."", ""source_locator"": ""Methods, Cloning, Expression and Purification (#s2a, second paragraph); Results, Overview of the Crystal Structures (#s3a, first paragraph).""}]"	"[{""id"": ""MetaCyc:EG12438-MONOMER"", ""source_sha256"": ""89275c24ed662a732a02f0b2f76dc720b86cbcba7dd4f54ef0e03a091aebb2b1"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native EG12438-MONOMER identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:EG12438-MONOMER""}, {""id"": ""PMID:18284213"", ""source_sha256"": ""88e67c3c142a44ca8eb07df2d17081749cfa83a0739157a488ffd07f305c23bb"", ""source_version"": ""Europe PMC indexed primary abstract inspected; full text not claimed; retrieved 2026-10-11 UTC"", ""title"": ""Identification and characterization of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A9150206+OR+EXT_ID%3A9795253+OR+EXT_ID%3A17760421+OR+EXT_ID%3A18284213+OR+EXT_ID%3A20643650+OR+EXT_ID%3A23564174+OR+EXT_ID%3A24992697+OR+EXT_ID%3A25010423+OR+EXT_ID%3A9573170+OR+EXT_ID%3A9045837+OR+EXT_ID%3A8037730+OR+EXT_ID%3A30912442+OR+EXT_ID%3A39422507+OR+EXT_ID%3A10978150+OR+EXT_ID%3A8764478+OR+EXT_ID%3A26394156+OR+EXT_ID%3A14621995&format=json&resultType=core&pageSize=100""}, {""id"": ""PMID:23637813"", ""source_sha256"": ""3a09918deee6b20b79a67c4687b6e904d3fc2f4ac109aa76f66f5545ff93c169"", ""source_version"": ""Primary article body inspected; retrieved 2026-10-11 UTC"", ""title"": ""Crystal Structures of E. coli Native MenH and Two Active Site Mutants"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3630204/""}, {""id"": ""RHEA:25598"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P37355"", ""source_sha256"": ""7af1247793748a32354761989fbbbeb34dc21659459ed0ddc15ea36dd28de1da"", ""source_version"": ""UniProt entry version 171, sequence version 2; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37355.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-055_dbb52aeb5b1f	RHEA:25598	BFO:0000050	MetaCyc:PWY-5838	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5837|MetaCyc:PWY-5838|MetaCyc:RXN-9310|RHEA:25598		"[{""reference_id"": ""MetaCyc:PWY-5838"", ""source_assertion"": ""The complete superpathway explicitly includes PWY-5837 as a pathway member."", ""source_locator"": ""Pathway[@frameid=\""PWY-5838\""]/reaction-list/Pathway/@frameid""}, {""reference_id"": ""MetaCyc:PWY-5837"", ""source_assertion"": ""The full native subpathway includes RXN-9310 and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-5837\""]/reaction-list/Reaction/@frameid; reaction-layout[Reaction/@frameid=\""RXN-9310\""]/direction""}, {""reference_id"": ""MetaCyc:RXN-9310"", ""source_assertion"": ""The native reaction explicitly cross-references RHEA:25598."", ""source_locator"": ""Reaction[@frameid=\""RXN-9310\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:25598"", ""source_assertion"": ""RHEA:25597 explicitly links the left-to-right directional reaction RHEA:25598."", ""source_locator"": ""http://rdf.rhea-db.org/25597 rh:directionalReaction http://rdf.rhea-db.org/25598; http://rdf.rhea-db.org/25598 rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""MetaCyc:PWY-5837"", ""source_sha256"": ""050bddf5109020329f96873d77e3dda7c99b1deea8bae9de800877541c2ba8c5"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5837 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5837""}, {""id"": ""MetaCyc:PWY-5838"", ""source_sha256"": ""d64dee995187648e7d1be403e38ef9824e68a729c1264d23af32f575973b78b8"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5838 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5838""}, {""id"": ""MetaCyc:RXN-9310"", ""source_sha256"": ""18139a6b89dad80d80996e5710d9464541c07bbb8797c69c2b3b4eed6d4bc2f6"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native RXN-9310 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9310""}, {""id"": ""RHEA:25598"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-056_8f4e06f07852	UniProtKB:P29208	pathwaymech:enables	RHEA:10197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:O-SUCCINYLBENZOATE-COA-SYN-MONOMER|PMID:10978150|RHEA:10197|UniProtKB:P29208	Functional activity is represented without asserting isolated-monomer sufficiency.	"[{""reference_id"": ""UniProtKB:P29208"", ""source_assertion"": ""The reviewed K-12 entry assigns this catalytic function with ECO:0000255 HAMAP-Rule:MF_00470, ECO:0000269 PubMed:10194342, ECO:0000269 PubMed:8335646. Its Rhea reaction is RHEA:10196."", ""source_locator"": ""/organism/taxonId; /comments/1/reaction/name; /comments/1/reaction/reactionCrossReferences; /comments/1/reaction/evidences""}, {""reference_id"": ""RHEA:10197"", ""source_assertion"": ""RHEA:10196 explicitly links the left-to-right directional reaction RHEA:10197."", ""source_locator"": ""http://rdf.rhea-db.org/10196 rh:directionalReaction http://rdf.rhea-db.org/10197; http://rdf.rhea-db.org/10197 rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""MetaCyc:O-SUCCINYLBENZOATE-COA-SYN-MONOMER"", ""source_assertion"": ""Native O-SUCCINYLBENZOATE-COA-SYN-MONOMER explicitly links its catalyzed enzymatic reaction to O-SUCCINYLBENZOATE-COA-SYN-RXN; this supports the reaction assignment."", ""source_locator"": ""Protein[@frameid=\""O-SUCCINYLBENZOATE-COA-SYN-MONOMER\""]/catalyzes/Enzymatic-Reaction/reaction/Reaction/@frameid""}, {""reference_id"": ""PMID:10978150"", ""source_assertion"": ""The primary abstract describes E. coli o-succinylbenzoate synthase and its Mg(2+)-OSB complex, with acid/base residues positioned for the dehydration reaction."", ""source_locator"": ""/resultList/result[id=\""10978150\""]/abstractText""}]"	"[{""id"": ""MetaCyc:O-SUCCINYLBENZOATE-COA-SYN-MONOMER"", ""source_sha256"": ""2b440ee00067bdb532bb8dd6b039d0120ad0925e2c1310a9039238ba87fa33b4"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native O-SUCCINYLBENZOATE-COA-SYN-MONOMER identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:O-SUCCINYLBENZOATE-COA-SYN-MONOMER""}, {""id"": ""PMID:10978150"", ""source_sha256"": ""88e67c3c142a44ca8eb07df2d17081749cfa83a0739157a488ffd07f305c23bb"", ""source_version"": ""Europe PMC indexed primary abstract inspected; full text not claimed; retrieved 2026-10-11 UTC"", ""title"": ""Evolution of enzymatic activity in the enolase superfamily: structure of o-succinylbenzoate synthase from Escherichia coli in complex with Mg2+ and o-succinylbenzoate."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A9150206+OR+EXT_ID%3A9795253+OR+EXT_ID%3A17760421+OR+EXT_ID%3A18284213+OR+EXT_ID%3A20643650+OR+EXT_ID%3A23564174+OR+EXT_ID%3A24992697+OR+EXT_ID%3A25010423+OR+EXT_ID%3A9573170+OR+EXT_ID%3A9045837+OR+EXT_ID%3A8037730+OR+EXT_ID%3A30912442+OR+EXT_ID%3A39422507+OR+EXT_ID%3A10978150+OR+EXT_ID%3A8764478+OR+EXT_ID%3A26394156+OR+EXT_ID%3A14621995&format=json&resultType=core&pageSize=100""}, {""id"": ""RHEA:10197"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate => 2-succinylbenzoate + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P29208"", ""source_sha256"": ""6d7677f59ed90cebf877f362aed5f4f4a151fe69f48c1b4299fd8995928ce23e"", ""source_version"": ""UniProt entry version 193, sequence version 2; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 o-succinylbenzoate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P29208.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-057_4c574118e3ea	UniProtKB:P29208	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P29208		"[{""reference_id"": ""UniProtKB:P29208"", ""source_assertion"": ""The reviewed entry specifies CHEBI:18420 with ECO:0000269 PubMed:10978150."", ""source_locator"": ""/comments/2/cofactors""}]"	"[{""id"": ""UniProtKB:P29208"", ""source_sha256"": ""6d7677f59ed90cebf877f362aed5f4f4a151fe69f48c1b4299fd8995928ce23e"", ""source_version"": ""UniProt entry version 193, sequence version 2; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 o-succinylbenzoate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P29208.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-058_c6843075d410	RHEA:10197	BFO:0000050	MetaCyc:PWY-5838	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:O-SUCCINYLBENZOATE-COA-SYN-RXN|MetaCyc:PWY-5837|MetaCyc:PWY-5838|RHEA:10197		"[{""reference_id"": ""MetaCyc:PWY-5838"", ""source_assertion"": ""The complete superpathway explicitly includes PWY-5837 as a pathway member."", ""source_locator"": ""Pathway[@frameid=\""PWY-5838\""]/reaction-list/Pathway/@frameid""}, {""reference_id"": ""MetaCyc:PWY-5837"", ""source_assertion"": ""The full native subpathway includes O-SUCCINYLBENZOATE-COA-SYN-RXN and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-5837\""]/reaction-list/Reaction/@frameid; reaction-layout[Reaction/@frameid=\""O-SUCCINYLBENZOATE-COA-SYN-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:O-SUCCINYLBENZOATE-COA-SYN-RXN"", ""source_assertion"": ""The native reaction explicitly cross-references RHEA:10197."", ""source_locator"": ""Reaction[@frameid=\""O-SUCCINYLBENZOATE-COA-SYN-RXN\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:10197"", ""source_assertion"": ""RHEA:10196 explicitly links the left-to-right directional reaction RHEA:10197."", ""source_locator"": ""http://rdf.rhea-db.org/10196 rh:directionalReaction http://rdf.rhea-db.org/10197; http://rdf.rhea-db.org/10197 rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""MetaCyc:O-SUCCINYLBENZOATE-COA-SYN-RXN"", ""source_sha256"": ""ecd60c124857bb118fd281839549a8f09596401e49293a5024ded2d17a9e5e08"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native O-SUCCINYLBENZOATE-COA-SYN-RXN identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:O-SUCCINYLBENZOATE-COA-SYN-RXN""}, {""id"": ""MetaCyc:PWY-5837"", ""source_sha256"": ""050bddf5109020329f96873d77e3dda7c99b1deea8bae9de800877541c2ba8c5"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5837 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5837""}, {""id"": ""MetaCyc:PWY-5838"", ""source_sha256"": ""d64dee995187648e7d1be403e38ef9824e68a729c1264d23af32f575973b78b8"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5838 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5838""}, {""id"": ""RHEA:10197"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate => 2-succinylbenzoate + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-059_3e30da47523c	UniProtKB:P37353	pathwaymech:enables	RHEA:17010	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	DOI:10.2210/pdb5C5H/pdb|DOI:10.2210/pdb6NJ0/pdb|MetaCyc:MENE-CPLX|PMID:26394156|PMID:30912442|RHEA:17010|UniProtKB:P37353	Supported MenE function; native tetramer and reviewed homodimer-by-similarity assignments conflict, while inhibitor-bound author/PISA structures are monomeric. No unique oligomer is asserted.	"[{""reference_id"": ""UniProtKB:P37353"", ""source_assertion"": ""The reviewed K-12 entry assigns this catalytic function with ECO:0000255 HAMAP-Rule:MF_00731, ECO:0000269 PubMed:22109989, ECO:0000269 PubMed:26394156. Its Rhea reaction is RHEA:17009."", ""source_locator"": ""/organism/taxonId; /comments/1/reaction/name; /comments/1/reaction/reactionCrossReferences; /comments/1/reaction/evidences""}, {""reference_id"": ""RHEA:17010"", ""source_assertion"": ""RHEA:17009 explicitly links the left-to-right directional reaction RHEA:17010."", ""source_locator"": ""http://rdf.rhea-db.org/17009 rh:directionalReaction http://rdf.rhea-db.org/17010; http://rdf.rhea-db.org/17010 rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""MetaCyc:MENE-CPLX"", ""source_assertion"": ""Native MENE-CPLX explicitly links its catalyzed enzymatic reaction to O-SUCCINYLBENZOATE-COA-LIG-RXN; this supports the reaction assignment."", ""source_locator"": ""Protein[@frameid=\""MENE-CPLX\""]/catalyzes/Enzymatic-Reaction/reaction/Reaction/@frameid""}, {""reference_id"": ""PMID:26394156"", ""source_assertion"": ""Purified E. coli MenE is assayed with OSB, ATP and CoA in a MenB-coupled reaction; MgCl2 is present. This establishes activity, not a unique physiological oligomer."", ""source_locator"": ""Materials and Methods, Enzyme assays (#P10); Results and Discussion, Role of R195 in OSB-CoA formation and inhibition of MenE; Table 2 (#P39).""}, {""reference_id"": ""MetaCyc:MENE-CPLX"", ""source_assertion"": ""The native complex has four copies of O-SUCCINYLBENZOATE-COA-LIG-MONOMER; this conflicts with the current reviewed assembly annotation and is not installed as a resolved physical assembly."", ""source_locator"": ""Protein[@frameid=\""MENE-CPLX\""]/component/Protein; component/coefficient""}, {""reference_id"": ""UniProtKB:P37353"", ""source_assertion"": ""SUBUNIT assigns Homodimer by similarity (ECO:0000250 UniProtKB:P23971)."", ""source_locator"": ""/comments/6/texts""}, {""reference_id"": ""DOI:10.2210/pdb6NJ0/pdb"", ""source_assertion"": ""For PDB 6NJ0, author- and PISA-defined biological assembly 1 is monomeric. Protein, variant and ligand identities are separately grounded in the cited primary article; this assembly does not resolve all solution or catalytic conditions."", ""source_locator"": ""/pdbx_struct_assembly/oligomeric_count; /pdbx_struct_assembly/oligomeric_details; /pdbx_struct_assembly/details; /pdbx_struct_assembly/method_details; /rcsb_struct_symmetry""}, {""reference_id"": ""DOI:10.2210/pdb5C5H/pdb"", ""source_assertion"": ""For PDB 5C5H, author- and PISA-defined biological assembly 1 is monomeric. Protein, variant and ligand identities are separately grounded in the cited primary article; this assembly does not resolve all solution or catalytic conditions."", ""source_locator"": ""/pdbx_struct_assembly/oligomeric_count; /pdbx_struct_assembly/oligomeric_details; /pdbx_struct_assembly/details; /pdbx_struct_assembly/method_details; /rcsb_struct_symmetry""}, {""reference_id"": ""PMID:30912442"", ""source_assertion"": ""The primary Methods and Results identify PDB 6NJ0 as wild-type E. coli MenE co-crystallized with m-phenyl ether inhibitor analogue 5. The structure used R195K E. coli MenE bound to OSB-AMS (5C5H) as a molecular-replacement model. These are inhibitor-bound structures, not evidence resolving all physiological assemblies."", ""source_locator"": ""PMC6653581 original HTML, Methods paragraph #P17; Results paragraph #P32.""}, {""reference_id"": ""PMID:26394156"", ""source_assertion"": ""The primary Results identify the R195K E. coli MenE mutant co-crystallized with OSB-AMS as PDB 5C5H; Methods give the crystallization conditions. This grounds the variant and ligand context separately from the RCSB assembly annotation."", ""source_locator"": ""PMC4624480 original HTML, Methods paragraph #P11; Results paragraph #P23.""}]"	"[{""id"": ""DOI:10.2210/pdb5C5H/pdb"", ""source_sha256"": ""de5a814d338a1656e19f702f2fc3d161eca3c7631548778124b57dd1aa65a308"", ""source_version"": ""Original RCSB assembly JSON retrieved 2026-10-11 UTC; inhibitor-bound structural context"", ""title"": ""RCSB biological assembly 1 for 5C5H R195K E. coli MenE with bound OSB-AMS"", ""url"": ""https://data.rcsb.org/rest/v1/core/assembly/5C5H/1""}, {""id"": ""DOI:10.2210/pdb6NJ0/pdb"", ""source_sha256"": ""711cc1b8b27497be201e99fc7dc3c078648f1764d538449329b9c020cd8d292c"", ""source_version"": ""Original RCSB assembly JSON retrieved 2026-10-11 UTC; inhibitor-bound structural context"", ""title"": ""RCSB biological assembly 1 for 6NJ0 wild-type E. coli MenE with a bound inhibitor analogue"", ""url"": ""https://data.rcsb.org/rest/v1/core/assembly/6NJ0/1""}, {""id"": ""MetaCyc:MENE-CPLX"", ""source_sha256"": ""51b78ebc7af53b66175cf41e8aa50133ed0f470470104e53eb305ffa870a0853"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native MENE-CPLX identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MENE-CPLX""}, {""id"": ""PMID:26394156"", ""source_sha256"": ""f4a8d851344a536bc7d5dead20245d0ce5bf0d52ebfad038cc407c5c3ef07756"", ""source_version"": ""Primary article body inspected; retrieved 2026-10-11 UTC"", ""title"": ""Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC4624480/""}, {""id"": ""PMID:30912442"", ""source_sha256"": ""7780cf50173d5f570480f707c0b912a00a900f3a16675cba7190dceea2accef4"", ""source_version"": ""2019; complete primary HTML retrieved 2026-10-11 UTC; inspected Methods P17 and Results P32"", ""title"": ""Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC6653581/""}, {""id"": ""RHEA:17010"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-succinylbenzoate + ATP + CoA => 2-succinylbenzoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P37353"", ""source_sha256"": ""c6df32f6b720f20715f901031d2ebf8eb7e4ab7dd88529234db154ee2a041a9f"", ""source_version"": ""UniProt entry version 177, sequence version 2; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 2-succinylbenzoate--CoA ligase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P37353.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-060_3e91f40dae5e	RHEA:17010	BFO:0000050	MetaCyc:PWY-5838	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:O-SUCCINYLBENZOATE-COA-LIG-RXN|MetaCyc:PWY-5837|MetaCyc:PWY-5838|RHEA:17010		"[{""reference_id"": ""MetaCyc:PWY-5838"", ""source_assertion"": ""The complete superpathway explicitly includes PWY-5837 as a pathway member."", ""source_locator"": ""Pathway[@frameid=\""PWY-5838\""]/reaction-list/Pathway/@frameid""}, {""reference_id"": ""MetaCyc:PWY-5837"", ""source_assertion"": ""The full native subpathway includes O-SUCCINYLBENZOATE-COA-LIG-RXN and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-5837\""]/reaction-list/Reaction/@frameid; reaction-layout[Reaction/@frameid=\""O-SUCCINYLBENZOATE-COA-LIG-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:O-SUCCINYLBENZOATE-COA-LIG-RXN"", ""source_assertion"": ""The native reaction explicitly cross-references RHEA:17010."", ""source_locator"": ""Reaction[@frameid=\""O-SUCCINYLBENZOATE-COA-LIG-RXN\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:17010"", ""source_assertion"": ""RHEA:17009 explicitly links the left-to-right directional reaction RHEA:17010."", ""source_locator"": ""http://rdf.rhea-db.org/17009 rh:directionalReaction http://rdf.rhea-db.org/17010; http://rdf.rhea-db.org/17010 rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""MetaCyc:O-SUCCINYLBENZOATE-COA-LIG-RXN"", ""source_sha256"": ""505b11e45bf14c05e9033b85f40e1de75fdbff2791f152844c9e246795362f34"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native O-SUCCINYLBENZOATE-COA-LIG-RXN identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:O-SUCCINYLBENZOATE-COA-LIG-RXN""}, {""id"": ""MetaCyc:PWY-5837"", ""source_sha256"": ""050bddf5109020329f96873d77e3dda7c99b1deea8bae9de800877541c2ba8c5"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5837 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5837""}, {""id"": ""MetaCyc:PWY-5838"", ""source_sha256"": ""d64dee995187648e7d1be403e38ef9824e68a729c1264d23af32f575973b78b8"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5838 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5838""}, {""id"": ""RHEA:17010"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-succinylbenzoate + ATP + CoA => 2-succinylbenzoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-061_154bc9f41c15	MetaCyc:CPLX0-7882	pathwaymech:catalyzes	RHEA:26563	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7882|PMID:20643650|RHEA:26563|UniProtKB:P0ABU0		"[{""reference_id"": ""UniProtKB:P0ABU0"", ""source_assertion"": ""The reviewed K-12 entry assigns this catalytic function with ECO:0000255 HAMAP-Rule:MF_01934, ECO:0000269 PubMed:20643650, ECO:0000269 PubMed:21830810, ECO:0000269 PubMed:22606952, ECO:0000269 PubMed:23658663. Its Rhea reaction is RHEA:26562."", ""source_locator"": ""/organism/taxonId; /comments/1/reaction/name; /comments/1/reaction/reactionCrossReferences; /comments/1/reaction/evidences""}, {""reference_id"": ""RHEA:26563"", ""source_assertion"": ""RHEA:26562 explicitly links the left-to-right directional reaction RHEA:26563."", ""source_locator"": ""http://rdf.rhea-db.org/26562 rh:directionalReaction http://rdf.rhea-db.org/26563; http://rdf.rhea-db.org/26563 rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""MetaCyc:CPLX0-7882"", ""source_assertion"": ""Native CPLX0-7882 explicitly links its catalyzed enzymatic reaction to NAPHTHOATE-SYN-RXN; this supports the reaction assignment."", ""source_locator"": ""Protein[@frameid=\""CPLX0-7882\""]/catalyzes/Enzymatic-Reaction/reaction/Reaction/@frameid""}, {""reference_id"": ""PMID:20643650"", ""source_assertion"": ""Untagged E. coli XL1 Blue MenB forms DHNA-CoA and is hexameric in solution; bicarbonate activates the enzyme. The tagged enzyme is inactive and no DHNA synthase activity was detected."", ""source_locator"": ""Experimental Procedures, Expression and Purification of Enzymes (#sec6); Results, Bicarbonate Activation of the EcMenB Activity (#sec15, first paragraph).""}]"	"[{""id"": ""MetaCyc:CPLX0-7882"", ""source_sha256"": ""02552ea1167d2be3fe94f416bb37a32ca39eea9efa1e408c848a3476785a473a"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native CPLX0-7882 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7882""}, {""id"": ""PMID:20643650"", ""source_sha256"": ""17b89c4f0fbf1f02265c257edfa7780233bea713fe4b6cfbdcacda489e8b44fb"", ""source_version"": ""Primary article body inspected; retrieved 2026-10-11 UTC"", ""title"": ""A bicarbonate cofactor modulates 1,4-dihydroxy-2-naphthoyl-coenzyme a synthase in menaquinone biosynthesis of Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2943303/""}, {""id"": ""RHEA:26563"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-succinylbenzoyl-CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0ABU0"", ""source_sha256"": ""a7fdc80f0e7cd702e5848df0eae76a53559ef388fe3255353f9dc7b36285b569"", ""source_version"": ""UniProt entry version 146, sequence version 1; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 1,4-dihydroxy-2-naphthoyl-CoA synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABU0.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-062_52716925e872	UniProtKB:P0ABU0	BFO:0000050	MetaCyc:CPLX0-7882	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7882|MetaCyc:NAPHTHOATE-SYN-MONOMER|UniProtKB:P0ABU0		"[{""reference_id"": ""MetaCyc:CPLX0-7882"", ""source_assertion"": ""The native MG1655 complex has 6 copies of NAPHTHOATE-SYN-MONOMER."", ""source_locator"": ""Protein[@frameid=\""CPLX0-7882\""]/component/Protein/@frameid; component/coefficient; species/Organism/@frameid""}, {""reference_id"": ""MetaCyc:NAPHTHOATE-SYN-MONOMER"", ""source_assertion"": ""The native protein explicitly unifies with UniProt P0ABU0."", ""source_locator"": ""Protein[@frameid=\""NAPHTHOATE-SYN-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid; dblink-relationship""}, {""reference_id"": ""UniProtKB:P0ABU0"", ""source_assertion"": ""SUBUNIT states Homohexamer. Dimer of a homotrimer; its evidence codes remain explicit in the original reviewed entry."", ""source_locator"": ""/comments/7/texts""}]"	"[{""id"": ""MetaCyc:CPLX0-7882"", ""source_sha256"": ""02552ea1167d2be3fe94f416bb37a32ca39eea9efa1e408c848a3476785a473a"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native CPLX0-7882 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7882""}, {""id"": ""MetaCyc:NAPHTHOATE-SYN-MONOMER"", ""source_sha256"": ""8cacb1b9bf52c766bffa270459e42331a76a2556756638c4203e256513133a6b"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native NAPHTHOATE-SYN-MONOMER identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:NAPHTHOATE-SYN-MONOMER""}, {""id"": ""UniProtKB:P0ABU0"", ""source_sha256"": ""a7fdc80f0e7cd702e5848df0eae76a53559ef388fe3255353f9dc7b36285b569"", ""source_version"": ""UniProt entry version 146, sequence version 1; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 1,4-dihydroxy-2-naphthoyl-CoA synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABU0.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-063_d537fee19dc2	MetaCyc:CPLX0-7882	pathwaymech:has_cofactor	CHEBI:17544	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:20643650|UniProtKB:P0ABU0		"[{""reference_id"": ""UniProtKB:P0ABU0"", ""source_assertion"": ""The reviewed entry specifies CHEBI:17544 with ECO:0000255 HAMAP-Rule:MF_01934, ECO:0000269 PubMed:20643650, ECO:0000305 PubMed:22606952. The hydrogencarbonate anion plays the same catalytic role (proton acceptor) as the side-chain carboxylate group of the essential 'Asp-185' found in actinobacteria, archaea, bacteroidetes, and deltaproteobacteria."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}, {""reference_id"": ""PMID:20643650"", ""source_assertion"": ""Purified untagged EcMenB activity depends on exogenous bicarbonate; the structural binding-site comparison used the closely related Salmonella enzyme."", ""source_locator"": ""Results, Bicarbonate Activation of the EcMenB Activity (#sec15) and Active Site and Bicarbonate Binding Site in EcMenB/StMenB; Discussion.""}]"	"[{""id"": ""PMID:20643650"", ""source_sha256"": ""17b89c4f0fbf1f02265c257edfa7780233bea713fe4b6cfbdcacda489e8b44fb"", ""source_version"": ""Primary article body inspected; retrieved 2026-10-11 UTC"", ""title"": ""A bicarbonate cofactor modulates 1,4-dihydroxy-2-naphthoyl-coenzyme a synthase in menaquinone biosynthesis of Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2943303/""}, {""id"": ""UniProtKB:P0ABU0"", ""source_sha256"": ""a7fdc80f0e7cd702e5848df0eae76a53559ef388fe3255353f9dc7b36285b569"", ""source_version"": ""UniProt entry version 146, sequence version 1; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 1,4-dihydroxy-2-naphthoyl-CoA synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0ABU0.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-064_88a766b2a8e6	RHEA:26563	BFO:0000050	MetaCyc:PWY-5838	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:NAPHTHOATE-SYN-RXN|MetaCyc:PWY-5837|MetaCyc:PWY-5838|RHEA:26563		"[{""reference_id"": ""MetaCyc:PWY-5838"", ""source_assertion"": ""The complete superpathway explicitly includes PWY-5837 as a pathway member."", ""source_locator"": ""Pathway[@frameid=\""PWY-5838\""]/reaction-list/Pathway/@frameid""}, {""reference_id"": ""MetaCyc:PWY-5837"", ""source_assertion"": ""The full native subpathway includes NAPHTHOATE-SYN-RXN and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-5837\""]/reaction-list/Reaction/@frameid; reaction-layout[Reaction/@frameid=\""NAPHTHOATE-SYN-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:NAPHTHOATE-SYN-RXN"", ""source_assertion"": ""The native reaction explicitly cross-references RHEA:26563."", ""source_locator"": ""Reaction[@frameid=\""NAPHTHOATE-SYN-RXN\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:26563"", ""source_assertion"": ""RHEA:26562 explicitly links the left-to-right directional reaction RHEA:26563."", ""source_locator"": ""http://rdf.rhea-db.org/26562 rh:directionalReaction http://rdf.rhea-db.org/26563; http://rdf.rhea-db.org/26563 rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""MetaCyc:NAPHTHOATE-SYN-RXN"", ""source_sha256"": ""fbc9b1268be67b54497722b7546c4b34da9d96d736257ae346a255b92e8e3952"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native NAPHTHOATE-SYN-RXN identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:NAPHTHOATE-SYN-RXN""}, {""id"": ""MetaCyc:PWY-5837"", ""source_sha256"": ""050bddf5109020329f96873d77e3dda7c99b1deea8bae9de800877541c2ba8c5"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5837 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5837""}, {""id"": ""MetaCyc:PWY-5838"", ""source_sha256"": ""d64dee995187648e7d1be403e38ef9824e68a729c1264d23af32f575973b78b8"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5838 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5838""}, {""id"": ""RHEA:26563"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-succinylbenzoyl-CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-065_8a5b99d423ef	MetaCyc:CPLX0-8128	pathwaymech:catalyzes	RHEA:26310	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8128|PMID:23564174|RHEA:26310|UniProtKB:P77781		"[{""reference_id"": ""UniProtKB:P77781"", ""source_assertion"": ""The reviewed K-12 entry assigns this catalytic function with ECO:0000255 HAMAP-Rule:MF_01936, ECO:0000269 PubMed:23564174, ECO:0000269 PubMed:24992697. Its Rhea reaction is RHEA:26309."", ""source_locator"": ""/organism/taxonId; /comments/1/reaction/name; /comments/1/reaction/reactionCrossReferences; /comments/1/reaction/evidences""}, {""reference_id"": ""RHEA:26310"", ""source_assertion"": ""RHEA:26309 explicitly links the left-to-right directional reaction RHEA:26310."", ""source_locator"": ""http://rdf.rhea-db.org/26309 rh:directionalReaction http://rdf.rhea-db.org/26310; http://rdf.rhea-db.org/26310 rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""MetaCyc:CPLX0-8128"", ""source_assertion"": ""Native CPLX0-8128 explicitly links its catalyzed enzymatic reaction to RXN-9311; this supports the reaction assignment."", ""source_locator"": ""Protein[@frameid=\""CPLX0-8128\""]/catalyzes/Enzymatic-Reaction/reaction/Reaction/@frameid""}, {""reference_id"": ""PMID:23564174"", ""source_assertion"": ""MG1655-derived recombinant YdiI hydrolyzes DHNA-CoA. BW25113 deletion mutants have reduced menaquinone production; residual production prevents an absolute indispensability claim."", ""source_locator"": ""Materials and Methods, Expression and purification of proteins (#sec4); Results and Discussion, Effect of the ydiI knockout on production of menaquinone (#sec11).""}]"	"[{""id"": ""MetaCyc:CPLX0-8128"", ""source_sha256"": ""1f81854846eb162fa02185a98241883f5a73d503da12fe8b4221a448671f11d0"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native CPLX0-8128 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8128""}, {""id"": ""PMID:23564174"", ""source_sha256"": ""44af8e69c22e4cca4b7bb80de3064852d7a3d5d03408072bab08875248a6861d"", ""source_version"": ""Primary article body inspected; retrieved 2026-10-11 UTC"", ""title"": ""Identification of a hotdog fold thioesterase involved in the biosynthesis of menaquinone in Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3697248/""}, {""id"": ""RHEA:26310"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""1,4-dihydroxy-2-naphthoyl-CoA + H2O => 1,4-dihydroxy-2-naphthoate + CoA + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P77781"", ""source_sha256"": ""8b0ea9cf95b8182181c5bc4b020ebe9544a8101af9ee45d90ce23062bce425e3"", ""source_version"": ""UniProt entry version 172, sequence version 1; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 1,4-dihydroxy-2-naphthoyl-CoA hydrolase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77781.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-066_6fd8f160a7e7	UniProtKB:P77781	BFO:0000050	MetaCyc:CPLX0-8128	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-8128|MetaCyc:G6912-MONOMER|PMID:25010423|UniProtKB:P77781		"[{""reference_id"": ""MetaCyc:CPLX0-8128"", ""source_assertion"": ""The native MG1655 complex has 4 copies of G6912-MONOMER."", ""source_locator"": ""Protein[@frameid=\""CPLX0-8128\""]/component/Protein/@frameid; component/coefficient; species/Organism/@frameid""}, {""reference_id"": ""MetaCyc:G6912-MONOMER"", ""source_assertion"": ""The native protein explicitly unifies with UniProt P77781."", ""source_locator"": ""Protein[@frameid=\""G6912-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid; dblink-relationship""}, {""reference_id"": ""UniProtKB:P77781"", ""source_assertion"": ""SUBUNIT states Homotetramer. Dimer of dimers; its evidence codes remain explicit in the original reviewed entry."", ""source_locator"": ""/comments/5/texts""}, {""reference_id"": ""PMID:25010423"", ""source_assertion"": ""The YdiI quaternary structure is a dimer of dimers with active sites spanning subunits."", ""source_locator"": ""Results and Discussion, Structural Determinants of YbdB and YdiI Substrate Specificity and Catalysis (sec3.1, second paragraph); Figure 1B-D.""}]"	"[{""id"": ""MetaCyc:CPLX0-8128"", ""source_sha256"": ""1f81854846eb162fa02185a98241883f5a73d503da12fe8b4221a448671f11d0"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native CPLX0-8128 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-8128""}, {""id"": ""MetaCyc:G6912-MONOMER"", ""source_sha256"": ""2818598cd5b63ea679ad5d702805e6b646957429f8e0440e5c4bced3b68ca1ca"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native G6912-MONOMER identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G6912-MONOMER""}, {""id"": ""PMID:25010423"", ""source_sha256"": ""dc6f06a5e9076d94e0016621bd0e57bfc78aeb423d4462079f0d666cca2f47e3"", ""source_version"": ""Primary article body inspected; retrieved 2026-10-11 UTC"", ""title"": ""Structure and catalysis in the Escherichia coli hotdog-fold thioesterase paralogs YdiI and YbdB."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4116151/fullTextXML""}, {""id"": ""UniProtKB:P77781"", ""source_sha256"": ""8b0ea9cf95b8182181c5bc4b020ebe9544a8101af9ee45d90ce23062bce425e3"", ""source_version"": ""UniProt entry version 172, sequence version 1; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 1,4-dihydroxy-2-naphthoyl-CoA hydrolase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77781.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-067_55b40fcae8c2	RHEA:26310	BFO:0000050	MetaCyc:PWY-5838	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5837|MetaCyc:PWY-5838|MetaCyc:RXN-9311|RHEA:26310		"[{""reference_id"": ""MetaCyc:PWY-5838"", ""source_assertion"": ""The complete superpathway explicitly includes PWY-5837 as a pathway member."", ""source_locator"": ""Pathway[@frameid=\""PWY-5838\""]/reaction-list/Pathway/@frameid""}, {""reference_id"": ""MetaCyc:PWY-5837"", ""source_assertion"": ""The full native subpathway includes RXN-9311 and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-5837\""]/reaction-list/Reaction/@frameid; reaction-layout[Reaction/@frameid=\""RXN-9311\""]/direction""}, {""reference_id"": ""MetaCyc:RXN-9311"", ""source_assertion"": ""The native reaction explicitly cross-references RHEA:26310."", ""source_locator"": ""Reaction[@frameid=\""RXN-9311\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:26310"", ""source_assertion"": ""RHEA:26309 explicitly links the left-to-right directional reaction RHEA:26310."", ""source_locator"": ""http://rdf.rhea-db.org/26309 rh:directionalReaction http://rdf.rhea-db.org/26310; http://rdf.rhea-db.org/26310 rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""MetaCyc:PWY-5837"", ""source_sha256"": ""050bddf5109020329f96873d77e3dda7c99b1deea8bae9de800877541c2ba8c5"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5837 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5837""}, {""id"": ""MetaCyc:PWY-5838"", ""source_sha256"": ""d64dee995187648e7d1be403e38ef9824e68a729c1264d23af32f575973b78b8"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5838 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5838""}, {""id"": ""MetaCyc:RXN-9311"", ""source_sha256"": ""b74a123d14e3fcc4634cec22012fbf16ba887659a5330f2b56880f38eead9f64"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native RXN-9311 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9311""}, {""id"": ""RHEA:26310"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""1,4-dihydroxy-2-naphthoyl-CoA + H2O => 1,4-dihydroxy-2-naphthoate + CoA + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-068_fb658e84b83e	MetaCyc:CPLX0-7426	pathwaymech:catalyzes	RHEA:27799	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7426|PMID:8037730|RHEA:27799|UniProtKB:P0AD57		"[{""reference_id"": ""UniProtKB:P0AD57"", ""source_assertion"": ""The reviewed K-12 entry assigns this catalytic function with ECO:0000269 PubMed:8037730. Its Rhea reaction is RHEA:27798."", ""source_locator"": ""/organism/taxonId; /comments/1/reaction/name; /comments/1/reaction/reactionCrossReferences; /comments/1/reaction/evidences""}, {""reference_id"": ""RHEA:27799"", ""source_assertion"": ""RHEA:27798 explicitly links the left-to-right directional reaction RHEA:27799."", ""source_locator"": ""http://rdf.rhea-db.org/27798 rh:directionalReaction http://rdf.rhea-db.org/27799; http://rdf.rhea-db.org/27799 rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""MetaCyc:CPLX0-7426"", ""source_assertion"": ""Native CPLX0-7426 explicitly links its catalyzed enzymatic reaction to RXN-8992; this supports the reaction assignment."", ""source_locator"": ""Protein[@frameid=\""CPLX0-7426\""]/catalyzes/Enzymatic-Reaction/reaction/Reaction/@frameid""}, {""reference_id"": ""PMID:8037730"", ""source_assertion"": ""The primary abstract assigns E. coli ispB by increased prenyltransferase activity and product analysis identifying the phosphate ester of all-E-octaprenol."", ""source_locator"": ""/resultList/result[id=\""8037730\""]/abstractText""}]"	"[{""id"": ""MetaCyc:CPLX0-7426"", ""source_sha256"": ""e57ff5537af2b03143921a96225336ca181a712831f3929b6055a0f073bfeda8"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native CPLX0-7426 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7426""}, {""id"": ""PMID:8037730"", ""source_sha256"": ""88e67c3c142a44ca8eb07df2d17081749cfa83a0739157a488ffd07f305c23bb"", ""source_version"": ""Europe PMC indexed primary abstract inspected; full text not claimed; retrieved 2026-10-11 UTC"", ""title"": ""The identification of Escherichia coli ispB (cel) gene encoding the octaprenyl diphosphate synthase."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A9150206+OR+EXT_ID%3A9795253+OR+EXT_ID%3A17760421+OR+EXT_ID%3A18284213+OR+EXT_ID%3A20643650+OR+EXT_ID%3A23564174+OR+EXT_ID%3A24992697+OR+EXT_ID%3A25010423+OR+EXT_ID%3A9573170+OR+EXT_ID%3A9045837+OR+EXT_ID%3A8037730+OR+EXT_ID%3A30912442+OR+EXT_ID%3A39422507+OR+EXT_ID%3A10978150+OR+EXT_ID%3A8764478+OR+EXT_ID%3A26394156+OR+EXT_ID%3A14621995&format=json&resultType=core&pageSize=100""}, {""id"": ""RHEA:27799"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""5 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate => all-trans-octaprenyl diphosphate + 5 diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0AD57"", ""source_sha256"": ""49e27dd3414b0c9fe23e180ef9c54808a1e9cf7003c5d9c254cf37b5a73a5f1f"", ""source_version"": ""UniProt entry version 143, sequence version 1; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 Octaprenyl diphosphate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AD57.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-069_f0eb78599787	UniProtKB:P0AD57	BFO:0000050	MetaCyc:CPLX0-7426	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-7426|MetaCyc:OPPSYN-MONOMER|PMID:11108713		"[{""reference_id"": ""MetaCyc:CPLX0-7426"", ""source_assertion"": ""The native MG1655 complex has 2 copies of OPPSYN-MONOMER."", ""source_locator"": ""Protein[@frameid=\""CPLX0-7426\""]/component/Protein/@frameid; component/coefficient; species/Organism/@frameid""}, {""reference_id"": ""MetaCyc:OPPSYN-MONOMER"", ""source_assertion"": ""The native protein explicitly unifies with UniProt P0AD57."", ""source_locator"": ""Protein[@frameid=\""OPPSYN-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]/dblink-oid; dblink-relationship""}, {""reference_id"": ""PMID:11108713"", ""source_assertion"": ""The primary abstract demonstrates IspB dimer formation and altered chain length in a tagged wild-type/mutant heterodimer; this corroborates dimerization without assigning the mutant phenotype to the wild type."", ""source_locator"": ""/resultList/result[id=\""11108713\""]/abstractText""}]"	"[{""id"": ""MetaCyc:CPLX0-7426"", ""source_sha256"": ""e57ff5537af2b03143921a96225336ca181a712831f3929b6055a0f073bfeda8"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native CPLX0-7426 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-7426""}, {""id"": ""MetaCyc:OPPSYN-MONOMER"", ""source_sha256"": ""3cdecba29d6c308848d6c6bb90bd71d4688d24d65e29a523c1812fcaffdba01c"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native OPPSYN-MONOMER identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:OPPSYN-MONOMER""}, {""id"": ""PMID:11108713"", ""source_sha256"": ""5b91f10981fe7631f1f800d4e32e3436e7e36b524830d88f88a23c22e32e7f29"", ""source_version"": ""Europe PMC indexed primary abstract inspected; full text not claimed; retrieved 2026-10-11 UTC"", ""title"": ""Dimer formation of octaprenyl-diphosphate synthase (IspB) is essential for chain length determination of ubiquinone."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A11108713%20OR%20EXT_ID%3A41507964%20OR%20EXT_ID%3A23690938&format=json&resultType=core&pageSize=100""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-070_ba71ec8cf1e3	MetaCyc:CPLX0-7426	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0AD57	The IspB magnesium assignment and two ions per subunit are by similarity.	"[{""reference_id"": ""UniProtKB:P0AD57"", ""source_assertion"": ""The reviewed entry specifies CHEBI:18420 with ECO:0000250 :. Binds 2 Mg(2+) ions per subunit."", ""source_locator"": ""/comments/2/cofactors; /comments/2/note""}]"	"[{""id"": ""UniProtKB:P0AD57"", ""source_sha256"": ""49e27dd3414b0c9fe23e180ef9c54808a1e9cf7003c5d9c254cf37b5a73a5f1f"", ""source_version"": ""UniProt entry version 143, sequence version 1; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 Octaprenyl diphosphate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AD57.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-071_5471d7f2889a	RHEA:27799	BFO:0000050	MetaCyc:PWY-5838	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5783|MetaCyc:PWY-5838|MetaCyc:RXN-8992|RHEA:27799		"[{""reference_id"": ""MetaCyc:PWY-5838"", ""source_assertion"": ""The complete superpathway explicitly includes PWY-5783 as a pathway member."", ""source_locator"": ""Pathway[@frameid=\""PWY-5838\""]/reaction-list/Pathway/@frameid""}, {""reference_id"": ""MetaCyc:PWY-5783"", ""source_assertion"": ""The full native subpathway includes RXN-8992 and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-5783\""]/reaction-list/Reaction/@frameid; reaction-layout[Reaction/@frameid=\""RXN-8992\""]/direction""}, {""reference_id"": ""MetaCyc:RXN-8992"", ""source_assertion"": ""The native reaction explicitly cross-references RHEA:27799."", ""source_locator"": ""Reaction[@frameid=\""RXN-8992\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:27799"", ""source_assertion"": ""RHEA:27798 explicitly links the left-to-right directional reaction RHEA:27799."", ""source_locator"": ""http://rdf.rhea-db.org/27798 rh:directionalReaction http://rdf.rhea-db.org/27799; http://rdf.rhea-db.org/27799 rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""MetaCyc:PWY-5783"", ""source_sha256"": ""3e5c585135898162244def8890f578da74190c843ca16053162d0eec2821b83c"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5783 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5783""}, {""id"": ""MetaCyc:PWY-5838"", ""source_sha256"": ""d64dee995187648e7d1be403e38ef9824e68a729c1264d23af32f575973b78b8"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5838 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5838""}, {""id"": ""MetaCyc:RXN-8992"", ""source_sha256"": ""f798dac942978f4052a7ca25ea692364ca5481ce3e5b252da230cca987719a1b"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native RXN-8992 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-8992""}, {""id"": ""RHEA:27799"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""5 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate => all-trans-octaprenyl diphosphate + 5 diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-072_53f46c272c8e	UniProtKB:P32166	pathwaymech:enables	RHEA:30100	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DMK-MONOMER|PMID:9573170|RHEA:30100|UniProtKB:P32166	Functional activity is represented without asserting isolated-monomer sufficiency.	"[{""reference_id"": ""UniProtKB:P32166"", ""source_assertion"": ""The reviewed K-12 entry assigns this catalytic function with ECO:0000255 HAMAP-Rule:MF_01937, ECO:0000269 PubMed:9573170. Its Rhea reaction is RHEA:26478."", ""source_locator"": ""/organism/taxonId; /comments/1/reaction/name; /comments/1/reaction/reactionCrossReferences; /comments/1/reaction/evidences""}, {""reference_id"": ""RHEA:30100"", ""source_assertion"": ""RHEA:30099 explicitly links the left-to-right directional reaction RHEA:30100."", ""source_locator"": ""http://rdf.rhea-db.org/30099 rh:directionalReaction http://rdf.rhea-db.org/30100; http://rdf.rhea-db.org/30100 rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""RHEA:30100"", ""source_assertion"": ""Exact octaprenyl master RHEA:30099 is explicitly rdfs:subClassOf generic RHEA:26478; the selected native reaction fixes the eight-unit chain."", ""source_locator"": ""http://rdf.rhea-db.org/30099 rdfs:subClassOf http://rdf.rhea-db.org/26478; http://rdf.rhea-db.org/30099 rh:directionalReaction http://rdf.rhea-db.org/30100""}, {""reference_id"": ""MetaCyc:DMK-MONOMER"", ""source_assertion"": ""Native DMK-MONOMER explicitly links its catalyzed enzymatic reaction to DMK-RXN; this supports the reaction assignment."", ""source_locator"": ""Protein[@frameid=\""DMK-MONOMER\""]/catalyzes/Enzymatic-Reaction/reaction/Reaction/@frameid""}, {""reference_id"": ""PMID:9573170"", ""source_assertion"": ""K-12 menA mutant complementation restores MK-8/DMK-8 and membrane prenyltransferase activity. The assay used farnesyl diphosphate; natural octaprenyl use is discussed from prior work. Oxidation to the extracted quinone is described as thought spontaneous, not a demonstrated additional biosynthetic enzyme."", ""source_locator"": ""Bacterial strains and growth conditions; Isolation of membranes and assay of DHNA octaprenyltransferase (#sec6); Analysis of menaquinones and octaprenyltransferase activity in various strains; introductory paragraph beginning The conversion of DHNA to DMK, and Figure 1.""}]"	"[{""id"": ""MetaCyc:DMK-MONOMER"", ""source_sha256"": ""21f409abfc64b33dc9f392719435adcd997db3c5c6a6c3573ca4d20b74fda246"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native DMK-MONOMER identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DMK-MONOMER""}, {""id"": ""PMID:9573170"", ""source_sha256"": ""7783345d801962b37134f7772ef6f79bb177a3574b65b60ef54e90086de571b9"", ""source_version"": ""Primary article body inspected; retrieved 2026-10-11 UTC"", ""title"": ""Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menA gene from Escherichia coli."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC107237/""}, {""id"": ""RHEA:30100"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""all-trans-octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P32166"", ""source_sha256"": ""824ad42f005728858124bffe4d91ecbc736b523aed4e90ffe988adf4f9ae0a93"", ""source_version"": ""UniProt entry version 170, sequence version 1; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 1,4-dihydroxy-2-naphthoate octaprenyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P32166.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-073_eef005703e7a	RHEA:30100	BFO:0000050	MetaCyc:PWY-5838	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DMK-RXN|MetaCyc:PWY-5838|MetaCyc:PWY-5852|RHEA:30100		"[{""reference_id"": ""MetaCyc:PWY-5838"", ""source_assertion"": ""The complete superpathway explicitly includes PWY-5852 as a pathway member."", ""source_locator"": ""Pathway[@frameid=\""PWY-5838\""]/reaction-list/Pathway/@frameid""}, {""reference_id"": ""MetaCyc:PWY-5852"", ""source_assertion"": ""The full native subpathway includes DMK-RXN and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""PWY-5852\""]/reaction-list/Reaction/@frameid; reaction-layout[Reaction/@frameid=\""DMK-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:DMK-RXN"", ""source_assertion"": ""The native reaction explicitly cross-references RHEA:30100."", ""source_locator"": ""Reaction[@frameid=\""DMK-RXN\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:30100"", ""source_assertion"": ""RHEA:30099 explicitly links the left-to-right directional reaction RHEA:30100."", ""source_locator"": ""http://rdf.rhea-db.org/30099 rh:directionalReaction http://rdf.rhea-db.org/30100; http://rdf.rhea-db.org/30100 rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""MetaCyc:DMK-RXN"", ""source_sha256"": ""7081c7351ce80604bd1ac2d3fba4638e62007ec63f99b5669bd43446a9eae67c"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native DMK-RXN identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DMK-RXN""}, {""id"": ""MetaCyc:PWY-5838"", ""source_sha256"": ""d64dee995187648e7d1be403e38ef9824e68a729c1264d23af32f575973b78b8"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5838 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5838""}, {""id"": ""MetaCyc:PWY-5852"", ""source_sha256"": ""f81dcd14e6f9816d227613772600a267bbbc88bc6e690ee527ce9353086d147b"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5852 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5852""}, {""id"": ""RHEA:30100"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""all-trans-octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-074_c73b898e321d	UniProtKB:P0A887	pathwaymech:enables	RHEA:30064	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:2-OCTAPRENYL-METHOXY-BENZOQ-METH-MONOMER|PMID:9045837|RHEA:30064|UniProtKB:P0A887	Fixed-chain menaquinol methylation follows native and Rhea chemistry. The ubiquinone Ubi metabolon is not asserted as its required assembly here.	"[{""reference_id"": ""UniProtKB:P0A887"", ""source_assertion"": ""The reviewed K-12 entry assigns this catalytic function with ECO:0000255 HAMAP-Rule:MF_01813, ECO:0000269 PubMed:9045837. Its Rhea reaction is RHEA:42640."", ""source_locator"": ""/organism/taxonId; /comments/1/reaction/name; /comments/1/reaction/reactionCrossReferences; /comments/1/reaction/evidences""}, {""reference_id"": ""RHEA:30064"", ""source_assertion"": ""RHEA:30063 explicitly links the left-to-right directional reaction RHEA:30064."", ""source_locator"": ""http://rdf.rhea-db.org/30063 rh:directionalReaction http://rdf.rhea-db.org/30064; http://rdf.rhea-db.org/30064 rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""RHEA:30064"", ""source_assertion"": ""Exact octaprenyl master RHEA:30063 is explicitly rdfs:subClassOf generic RHEA:42640; the selected native reaction fixes the eight-unit chain."", ""source_locator"": ""http://rdf.rhea-db.org/30063 rdfs:subClassOf http://rdf.rhea-db.org/42640; http://rdf.rhea-db.org/30063 rh:directionalReaction http://rdf.rhea-db.org/30064""}, {""reference_id"": ""MetaCyc:2-OCTAPRENYL-METHOXY-BENZOQ-METH-MONOMER"", ""source_assertion"": ""Native 2-OCTAPRENYL-METHOXY-BENZOQ-METH-MONOMER explicitly links its catalyzed enzymatic reaction to ADOMET-DMK-METHYLTRANSFER-RXN; this supports the reaction assignment."", ""source_locator"": ""Protein[@frameid=\""2-OCTAPRENYL-METHOXY-BENZOQ-METH-MONOMER\""]/catalyzes/Enzymatic-Reaction/reaction/Reaction/@frameid""}, {""reference_id"": ""PMID:9045837"", ""source_assertion"": ""The primary abstract identifies UbiE through complementation, disruption and accumulated demethylmenaquinone. It supports C-methylation in both quinone pathways, without proving the redox state of every intracellular substrate."", ""source_locator"": ""/resultList/result[id=\""9045837\""]/abstractText""}]"	"[{""id"": ""MetaCyc:2-OCTAPRENYL-METHOXY-BENZOQ-METH-MONOMER"", ""source_sha256"": ""0b7237ed91377f8483c477c0a4e10b2a0b0123434fbbae87de57be5f40186c3c"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native 2-OCTAPRENYL-METHOXY-BENZOQ-METH-MONOMER identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:2-OCTAPRENYL-METHOXY-BENZOQ-METH-MONOMER""}, {""id"": ""PMID:9045837"", ""source_sha256"": ""88e67c3c142a44ca8eb07df2d17081749cfa83a0739157a488ffd07f305c23bb"", ""source_version"": ""Europe PMC indexed primary abstract inspected; full text not claimed; retrieved 2026-10-11 UTC"", ""title"": ""A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID%3A9150206+OR+EXT_ID%3A9795253+OR+EXT_ID%3A17760421+OR+EXT_ID%3A18284213+OR+EXT_ID%3A20643650+OR+EXT_ID%3A23564174+OR+EXT_ID%3A24992697+OR+EXT_ID%3A25010423+OR+EXT_ID%3A9573170+OR+EXT_ID%3A9045837+OR+EXT_ID%3A8037730+OR+EXT_ID%3A30912442+OR+EXT_ID%3A39422507+OR+EXT_ID%3A10978150+OR+EXT_ID%3A8764478+OR+EXT_ID%3A26394156+OR+EXT_ID%3A14621995&format=json&resultType=core&pageSize=100""}, {""id"": ""RHEA:30064"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-demethylmenaquinol-8 + S-adenosyl-L-methionine => menaquinol-8 + S-adenosyl-L-homocysteine + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0A887"", ""source_sha256"": ""b37acc90223421b400f8c2b0f5495ce3395325993f02c749319e8718cd04c0d3"", ""source_version"": ""UniProt entry version 158, sequence version 1; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A887.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-075_ecd6c1c65fc0	RHEA:30064	BFO:0000050	MetaCyc:PWY-5838	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:ADOMET-DMK-METHYLTRANSFER-RXN|MetaCyc:MENAQUINONESYN-PWY|MetaCyc:PWY-5838|RHEA:30064		"[{""reference_id"": ""MetaCyc:PWY-5838"", ""source_assertion"": ""The complete superpathway explicitly includes MENAQUINONESYN-PWY as a pathway member."", ""source_locator"": ""Pathway[@frameid=\""PWY-5838\""]/reaction-list/Pathway/@frameid""}, {""reference_id"": ""MetaCyc:MENAQUINONESYN-PWY"", ""source_assertion"": ""The full native subpathway includes ADOMET-DMK-METHYLTRANSFER-RXN and selects L2R in its reaction layout."", ""source_locator"": ""Pathway[@frameid=\""MENAQUINONESYN-PWY\""]/reaction-list/Reaction/@frameid; reaction-layout[Reaction/@frameid=\""ADOMET-DMK-METHYLTRANSFER-RXN\""]/direction""}, {""reference_id"": ""MetaCyc:ADOMET-DMK-METHYLTRANSFER-RXN"", ""source_assertion"": ""The native reaction explicitly cross-references RHEA:30064."", ""source_locator"": ""Reaction[@frameid=\""ADOMET-DMK-METHYLTRANSFER-RXN\""]/dblink[dblink-db=\""RHEA\""]/dblink-oid""}, {""reference_id"": ""RHEA:30064"", ""source_assertion"": ""RHEA:30063 explicitly links the left-to-right directional reaction RHEA:30064."", ""source_locator"": ""http://rdf.rhea-db.org/30063 rh:directionalReaction http://rdf.rhea-db.org/30064; http://rdf.rhea-db.org/30064 rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""MetaCyc:ADOMET-DMK-METHYLTRANSFER-RXN"", ""source_sha256"": ""8bddfc17d980a9cf5381dd22ccb578bef1b1aa3d8214dde5832271d9b4965ee7"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native ADOMET-DMK-METHYLTRANSFER-RXN identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:ADOMET-DMK-METHYLTRANSFER-RXN""}, {""id"": ""MetaCyc:MENAQUINONESYN-PWY"", ""source_sha256"": ""9eb43c126e2d68129d5804158ad3c5612260e3ba3345aeb57e99c08e6122e26f"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native MENAQUINONESYN-PWY identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:MENAQUINONESYN-PWY""}, {""id"": ""MetaCyc:PWY-5838"", ""source_sha256"": ""d64dee995187648e7d1be403e38ef9824e68a729c1264d23af32f575973b78b8"", ""source_version"": ""MetaCyc 22.5; complete native XML retrieved 2026-10-11 UTC"", ""title"": ""Native PWY-5838 identity and mechanism"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-5838""}, {""id"": ""RHEA:30064"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-demethylmenaquinol-8 + S-adenosyl-L-methionine => menaquinol-8 + S-adenosyl-L-homocysteine + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-076_5808fcc0712b	UniProtKB:P32166	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32166		"[{""reference_id"": ""UniProtKB:P32166"", ""source_assertion"": ""SUBCELLULAR LOCATION assigns MenA to the cell inner membrane as a multipass protein, with experimental PMID:15919996 and HAMAP support."", ""source_locator"": ""/comments/3/subcellularLocations""}]"	"[{""id"": ""UniProtKB:P32166"", ""source_sha256"": ""824ad42f005728858124bffe4d91ecbc736b523aed4e90ffe988adf4f9ae0a93"", ""source_version"": ""UniProt entry version 170, sequence version 1; retrieved 2026-10-11 UTC"", ""title"": ""Reviewed E. coli K-12 1,4-dihydroxy-2-naphthoate octaprenyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P32166.json""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-077_56e06c5a5afa	RHEA:18986	RO:0002413	RHEA:25594	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18986|RHEA:25594	Curated continuity through CHEBI:29780; no physical channeling or flux magnitude is asserted.	"[{""reference_id"": ""RHEA:18986"", ""source_assertion"": ""RHEA:18986 explicitly has shared intermediate CHEBI:29780 in its products."", ""source_locator"": ""http://rdf.rhea-db.org/18986 rh:products http://rdf.rhea-db.org/18985_R; http://rdf.rhea-db.org/18985_R rh:contains1 http://rdf.rhea-db.org/Participant_18985_compound_3577; http://rdf.rhea-db.org/Participant_18985_compound_3577 rh:compound http://rdf.rhea-db.org/Compound_3577; http://rdf.rhea-db.org/Compound_3577 rh:accession""}, {""reference_id"": ""RHEA:25594"", ""source_assertion"": ""RHEA:25594 explicitly has shared intermediate CHEBI:29780 in its substrates."", ""source_locator"": ""http://rdf.rhea-db.org/25594 rh:substrates http://rdf.rhea-db.org/25593_L; http://rdf.rhea-db.org/25593_L rh:contains1 http://rdf.rhea-db.org/Participant_25593_compound_3577; http://rdf.rhea-db.org/Participant_25593_compound_3577 rh:compound http://rdf.rhea-db.org/Compound_3577; http://rdf.rhea-db.org/Compound_3577 rh:accession""}]"	"[{""id"": ""RHEA:18986"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""chorismate => isochorismate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:25594"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""isochorismate + 2-oxoglutarate + H(+) => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-078_942b764e8ae7	RHEA:25594	RO:0002413	RHEA:25598	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:25594|RHEA:25598	Curated continuity through CHEBI:58818; no physical channeling or flux magnitude is asserted.	"[{""reference_id"": ""RHEA:25594"", ""source_assertion"": ""RHEA:25594 explicitly has shared intermediate CHEBI:58818 in its products."", ""source_locator"": ""http://rdf.rhea-db.org/25594 rh:products http://rdf.rhea-db.org/25593_R; http://rdf.rhea-db.org/25593_R rh:contains1 http://rdf.rhea-db.org/Participant_25593_compound_5683; http://rdf.rhea-db.org/Participant_25593_compound_5683 rh:compound http://rdf.rhea-db.org/Compound_5683; http://rdf.rhea-db.org/Compound_5683 rh:accession""}, {""reference_id"": ""RHEA:25598"", ""source_assertion"": ""RHEA:25598 explicitly has shared intermediate CHEBI:58818 in its substrates."", ""source_locator"": ""http://rdf.rhea-db.org/25598 rh:substrates http://rdf.rhea-db.org/25597_L; http://rdf.rhea-db.org/25597_L rh:contains1 http://rdf.rhea-db.org/Participant_25597_compound_5683; http://rdf.rhea-db.org/Participant_25597_compound_5683 rh:compound http://rdf.rhea-db.org/Compound_5683; http://rdf.rhea-db.org/Compound_5683 rh:accession""}]"	"[{""id"": ""RHEA:25594"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""isochorismate + 2-oxoglutarate + H(+) => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:25598"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-079_13d897bf3ff2	RHEA:25598	RO:0002413	RHEA:10197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10197|RHEA:25598	Curated continuity through CHEBI:58689; no physical channeling or flux magnitude is asserted.	"[{""reference_id"": ""RHEA:25598"", ""source_assertion"": ""RHEA:25598 explicitly has shared intermediate CHEBI:58689 in its products."", ""source_locator"": ""http://rdf.rhea-db.org/25598 rh:products http://rdf.rhea-db.org/25597_R; http://rdf.rhea-db.org/25597_R rh:contains1 http://rdf.rhea-db.org/Participant_25597_compound_5418; http://rdf.rhea-db.org/Participant_25597_compound_5418 rh:compound http://rdf.rhea-db.org/Compound_5418; http://rdf.rhea-db.org/Compound_5418 rh:accession""}, {""reference_id"": ""RHEA:10197"", ""source_assertion"": ""RHEA:10197 explicitly has shared intermediate CHEBI:58689 in its substrates."", ""source_locator"": ""http://rdf.rhea-db.org/10197 rh:substrates http://rdf.rhea-db.org/10196_L; http://rdf.rhea-db.org/10196_L rh:contains1 http://rdf.rhea-db.org/Participant_10196_compound_5418; http://rdf.rhea-db.org/Participant_10196_compound_5418 rh:compound http://rdf.rhea-db.org/Compound_5418; http://rdf.rhea-db.org/Compound_5418 rh:accession""}]"	"[{""id"": ""RHEA:10197"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate => 2-succinylbenzoate + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:25598"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-080_9e965b81a4e2	RHEA:10197	RO:0002413	RHEA:17010	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10197|RHEA:17010	Curated continuity through CHEBI:18325; no physical channeling or flux magnitude is asserted.	"[{""reference_id"": ""RHEA:10197"", ""source_assertion"": ""RHEA:10197 explicitly has shared intermediate CHEBI:18325 in its products."", ""source_locator"": ""http://rdf.rhea-db.org/10197 rh:products http://rdf.rhea-db.org/10196_R; http://rdf.rhea-db.org/10196_R rh:contains1 http://rdf.rhea-db.org/Participant_10196_compound_5241; http://rdf.rhea-db.org/Participant_10196_compound_5241 rh:compound http://rdf.rhea-db.org/Compound_5241; http://rdf.rhea-db.org/Compound_5241 rh:accession""}, {""reference_id"": ""RHEA:17010"", ""source_assertion"": ""RHEA:17010 explicitly has shared intermediate CHEBI:18325 in its substrates."", ""source_locator"": ""http://rdf.rhea-db.org/17010 rh:substrates http://rdf.rhea-db.org/17009_L; http://rdf.rhea-db.org/17009_L rh:contains1 http://rdf.rhea-db.org/Participant_17009_compound_5241; http://rdf.rhea-db.org/Participant_17009_compound_5241 rh:compound http://rdf.rhea-db.org/Compound_5241; http://rdf.rhea-db.org/Compound_5241 rh:accession""}]"	"[{""id"": ""RHEA:10197"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate => 2-succinylbenzoate + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:17010"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-succinylbenzoate + ATP + CoA => 2-succinylbenzoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-081_3df8ea1caea1	RHEA:17010	RO:0002413	RHEA:26563	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17010|RHEA:26563	Curated continuity through CHEBI:57364; no physical channeling or flux magnitude is asserted.	"[{""reference_id"": ""RHEA:17010"", ""source_assertion"": ""RHEA:17010 explicitly has shared intermediate CHEBI:57364 in its products."", ""source_locator"": ""http://rdf.rhea-db.org/17010 rh:products http://rdf.rhea-db.org/17009_R; http://rdf.rhea-db.org/17009_R rh:contains1 http://rdf.rhea-db.org/Participant_17009_compound_2208; http://rdf.rhea-db.org/Participant_17009_compound_2208 rh:compound http://rdf.rhea-db.org/Compound_2208; http://rdf.rhea-db.org/Compound_2208 rh:accession""}, {""reference_id"": ""RHEA:26563"", ""source_assertion"": ""RHEA:26563 explicitly has shared intermediate CHEBI:57364 in its substrates."", ""source_locator"": ""http://rdf.rhea-db.org/26563 rh:substrates http://rdf.rhea-db.org/26562_L; http://rdf.rhea-db.org/26562_L rh:contains1 http://rdf.rhea-db.org/Participant_26562_compound_2208; http://rdf.rhea-db.org/Participant_26562_compound_2208 rh:compound http://rdf.rhea-db.org/Compound_2208; http://rdf.rhea-db.org/Compound_2208 rh:accession""}]"	"[{""id"": ""RHEA:17010"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-succinylbenzoate + ATP + CoA => 2-succinylbenzoyl-CoA + AMP + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26563"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-succinylbenzoyl-CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-082_e065f3a0fd63	RHEA:26563	RO:0002413	RHEA:26310	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26310|RHEA:26563	Curated continuity through CHEBI:58897; no physical channeling or flux magnitude is asserted.	"[{""reference_id"": ""RHEA:26563"", ""source_assertion"": ""RHEA:26563 explicitly has shared intermediate CHEBI:58897 in its products."", ""source_locator"": ""http://rdf.rhea-db.org/26563 rh:products http://rdf.rhea-db.org/26562_R; http://rdf.rhea-db.org/26562_R rh:contains1 http://rdf.rhea-db.org/Participant_26562_compound_5962; http://rdf.rhea-db.org/Participant_26562_compound_5962 rh:compound http://rdf.rhea-db.org/Compound_5962; http://rdf.rhea-db.org/Compound_5962 rh:accession""}, {""reference_id"": ""RHEA:26310"", ""source_assertion"": ""RHEA:26310 explicitly has shared intermediate CHEBI:58897 in its substrates."", ""source_locator"": ""http://rdf.rhea-db.org/26310 rh:substrates http://rdf.rhea-db.org/26309_L; http://rdf.rhea-db.org/26309_L rh:contains1 http://rdf.rhea-db.org/Participant_26309_compound_5962; http://rdf.rhea-db.org/Participant_26309_compound_5962 rh:compound http://rdf.rhea-db.org/Compound_5962; http://rdf.rhea-db.org/Compound_5962 rh:accession""}]"	"[{""id"": ""RHEA:26310"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""1,4-dihydroxy-2-naphthoyl-CoA + H2O => 1,4-dihydroxy-2-naphthoate + CoA + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:26563"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-succinylbenzoyl-CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-083_5c05ad4a18a1	RHEA:26310	RO:0002413	RHEA:30100	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26310|RHEA:30100	Curated continuity through CHEBI:11173; no physical channeling or flux magnitude is asserted.	"[{""reference_id"": ""RHEA:26310"", ""source_assertion"": ""RHEA:26310 explicitly has shared intermediate CHEBI:11173 in its products."", ""source_locator"": ""http://rdf.rhea-db.org/26310 rh:products http://rdf.rhea-db.org/26309_R; http://rdf.rhea-db.org/26309_R rh:contains1 http://rdf.rhea-db.org/Participant_26309_compound_6107; http://rdf.rhea-db.org/Participant_26309_compound_6107 rh:compound http://rdf.rhea-db.org/Compound_6107; http://rdf.rhea-db.org/Compound_6107 rh:accession""}, {""reference_id"": ""RHEA:30100"", ""source_assertion"": ""RHEA:30100 explicitly has shared intermediate CHEBI:11173 in its substrates."", ""source_locator"": ""http://rdf.rhea-db.org/30100 rh:substrates http://rdf.rhea-db.org/30099_L; http://rdf.rhea-db.org/30099_L rh:contains1 http://rdf.rhea-db.org/Participant_30099_compound_6107; http://rdf.rhea-db.org/Participant_30099_compound_6107 rh:compound http://rdf.rhea-db.org/Compound_6107; http://rdf.rhea-db.org/Compound_6107 rh:accession""}]"	"[{""id"": ""RHEA:26310"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""1,4-dihydroxy-2-naphthoyl-CoA + H2O => 1,4-dihydroxy-2-naphthoate + CoA + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:30100"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""all-trans-octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-084_3774d438140e	RHEA:27799	RO:0002413	RHEA:30100	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:27799|RHEA:30100	Curated continuity through CHEBI:57711; no physical channeling or flux magnitude is asserted.	"[{""reference_id"": ""RHEA:27799"", ""source_assertion"": ""RHEA:27799 explicitly has shared intermediate CHEBI:57711 in its products."", ""source_locator"": ""http://rdf.rhea-db.org/27799 rh:products http://rdf.rhea-db.org/27798_R; http://rdf.rhea-db.org/27798_R rh:contains1 http://rdf.rhea-db.org/Participant_27798_compound_1744; http://rdf.rhea-db.org/Participant_27798_compound_1744 rh:compound http://rdf.rhea-db.org/Compound_1744; http://rdf.rhea-db.org/Compound_1744 rh:accession""}, {""reference_id"": ""RHEA:30100"", ""source_assertion"": ""RHEA:30100 explicitly has shared intermediate CHEBI:57711 in its substrates."", ""source_locator"": ""http://rdf.rhea-db.org/30100 rh:substrates http://rdf.rhea-db.org/30099_L; http://rdf.rhea-db.org/30099_L rh:contains1 http://rdf.rhea-db.org/Participant_30099_compound_1744; http://rdf.rhea-db.org/Participant_30099_compound_1744 rh:compound http://rdf.rhea-db.org/Compound_1744; http://rdf.rhea-db.org/Compound_1744 rh:accession""}]"	"[{""id"": ""RHEA:27799"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""5 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate => all-trans-octaprenyl diphosphate + 5 diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:30100"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""all-trans-octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY-5838_menaquinol-edge-085_72e65ef91df4	RHEA:30100	RO:0002413	RHEA:30064	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30064|RHEA:30100	Curated continuity through CHEBI:61873; no physical channeling or flux magnitude is asserted.	"[{""reference_id"": ""RHEA:30100"", ""source_assertion"": ""RHEA:30100 explicitly has shared intermediate CHEBI:61873 in its products."", ""source_locator"": ""http://rdf.rhea-db.org/30100 rh:products http://rdf.rhea-db.org/30099_R; http://rdf.rhea-db.org/30099_R rh:contains1 http://rdf.rhea-db.org/Participant_30099_compound_6609; http://rdf.rhea-db.org/Participant_30099_compound_6609 rh:compound http://rdf.rhea-db.org/Compound_6609; http://rdf.rhea-db.org/Compound_6609 rh:accession""}, {""reference_id"": ""RHEA:30064"", ""source_assertion"": ""RHEA:30064 explicitly has shared intermediate CHEBI:61873 in its substrates."", ""source_locator"": ""http://rdf.rhea-db.org/30064 rh:substrates http://rdf.rhea-db.org/30063_L; http://rdf.rhea-db.org/30063_L rh:contains1 http://rdf.rhea-db.org/Participant_30063_compound_6609; http://rdf.rhea-db.org/Participant_30063_compound_6609 rh:compound http://rdf.rhea-db.org/Compound_6609; http://rdf.rhea-db.org/Compound_6609 rh:accession""}]"	"[{""id"": ""RHEA:30064"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""2-demethylmenaquinol-8 + S-adenosyl-L-methionine => menaquinol-8 + S-adenosyl-L-homocysteine + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:30100"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, released 2026-09-02; digest covers full compressed RDF"", ""title"": ""all-trans-octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-1_1370a9cedc32	CHEBI:30031	pathwaymech:consumes	WikiPathways:WP296/b7797	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML b7797 connects normalized CHEBI:30031 as an input of interaction b7797."", ""source_locator"": ""/Pathway/Interaction[@GraphId='b7797']/Graphics; /Pathway/DataNode[@GraphId='c4f94']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-2_11c69ad67095	WikiPathways:WP296/b7797	pathwaymech:produces	CHEBI:29806	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML b7797 connects normalized CHEBI:29806 as an output of interaction b7797."", ""source_locator"": ""/Pathway/Interaction[@GraphId='b7797']/Graphics; /Pathway/DataNode[@GraphId='e24e6']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-3_7be9fcb31d5c	CHEBI:29806	pathwaymech:consumes	WikiPathways:WP296/bec38	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML bec38 connects normalized CHEBI:29806 as an input of interaction bec38."", ""source_locator"": ""/Pathway/Interaction[@GraphId='bec38']/Graphics; /Pathway/DataNode[@GraphId='e24e6']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-4_e33b0318d48b	WikiPathways:WP296/bec38	pathwaymech:produces	CHEBI:15589	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML bec38 connects normalized CHEBI:15589 as an output of interaction bec38."", ""source_locator"": ""/Pathway/Interaction[@GraphId='bec38']/Graphics; /Pathway/DataNode[@GraphId='e5fa5']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-5_c3eabee821fb	CHEBI:15589	pathwaymech:consumes	WikiPathways:WP296/c084d	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML c084d connects normalized CHEBI:15589 as an input of interaction c084d."", ""source_locator"": ""/Pathway/Interaction[@GraphId='c084d']/Graphics; /Pathway/DataNode[@GraphId='e5fa5']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-6_c093615d86d5	WikiPathways:WP296/c084d	pathwaymech:produces	CHEBI:30744	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML c084d connects normalized CHEBI:30744 as an output of interaction c084d."", ""source_locator"": ""/Pathway/Interaction[@GraphId='c084d']/Graphics; /Pathway/DataNode[@GraphId='aeccb']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-7_8e6fd7cf7a1e	CHEBI:16383	pathwaymech:consumes	WikiPathways:WP296/id21c76d83	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id21c76d83 connects normalized CHEBI:16383 as an input of interaction id21c76d83."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id21c76d83']/Graphics; /Pathway/DataNode[@GraphId='b0a18']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-8_8911ae5fb6a6	WikiPathways:WP296/id21c76d83	pathwaymech:produces	CHEBI:15562	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id21c76d83 connects normalized CHEBI:15562 as an output of interaction id21c76d83."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id21c76d83']/Graphics; /Pathway/DataNode[@GraphId='e08ee']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-9_b79b162c5f34	CHEBI:16810	pathwaymech:consumes	WikiPathways:WP296/id238f9689	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id238f9689 connects normalized CHEBI:16810 as an input of interaction id238f9689."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id238f9689']/Graphics; /Pathway/DataNode[@GraphId='e3a7b']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-10_e7c295b5f9ca	WikiPathways:WP296/id238f9689	pathwaymech:produces	CHEBI:57292	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id238f9689 connects normalized CHEBI:57292 as an output of interaction id238f9689."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id238f9689']/Graphics; /Pathway/DataNode[@GraphId='d87e7']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-11_c787b1d9152f	CHEBI:16947	pathwaymech:consumes	WikiPathways:WP296/id718be16e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id718be16e connects normalized CHEBI:16947 as an input of interaction id718be16e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id718be16e']/Graphics; /Pathway/DataNode[@GraphId='ec441']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-12_2ac03cb2c7a1	WikiPathways:WP296/id718be16e	pathwaymech:produces	CHEBI:16383	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id718be16e connects normalized CHEBI:16383 as an output of interaction id718be16e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id718be16e']/Graphics; /Pathway/DataNode[@GraphId='b0a18']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-13_ba207f56637f	CHEBI:30744	pathwaymech:consumes	WikiPathways:WP296/id892d5e82	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id892d5e82 connects normalized CHEBI:30744 as an input of interaction id892d5e82."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id892d5e82']/Graphics; /Pathway/DataNode[@GraphId='aeccb']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-14_24ab9bff688b	WikiPathways:WP296/id892d5e82	pathwaymech:produces	CHEBI:16947	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id892d5e82 connects normalized CHEBI:16947 as an output of interaction id892d5e82."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id892d5e82']/Graphics; /Pathway/DataNode[@GraphId='ec441']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-15_9ba691fde1f4	CHEBI:15562	pathwaymech:consumes	WikiPathways:WP296/ida3b8a465	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML ida3b8a465 connects normalized CHEBI:15562 as an input of interaction ida3b8a465."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ida3b8a465']/Graphics; /Pathway/DataNode[@GraphId='e08ee']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-16_0a90a9101f96	WikiPathways:WP296/ida3b8a465	pathwaymech:produces	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML ida3b8a465 connects normalized CHEBI:16810 as an output of interaction ida3b8a465."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ida3b8a465']/Graphics; /Pathway/DataNode[@GraphId='e3a7b']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-17_6886c7e847a5	CHEBI:57292	pathwaymech:consumes	WikiPathways:WP296/idaf5b761e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML idaf5b761e connects normalized CHEBI:57292 as an input of interaction idaf5b761e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idaf5b761e']/Graphics; /Pathway/DataNode[@GraphId='d87e7']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-18_76dea799ebbd	WikiPathways:WP296/idaf5b761e	pathwaymech:produces	CHEBI:30031	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML idaf5b761e connects normalized CHEBI:30031 as an output of interaction idaf5b761e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idaf5b761e']/Graphics; /Pathway/DataNode[@GraphId='c4f94']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-19_c692e52c9aad	WikiPathways:WP296/id718be16e	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML dfb97 connects normalized CHEBI:15377 as an output of interaction id718be16e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='dfb97']/Graphics; /Pathway/DataNode[@GraphId='e5e79']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-20_a78058f2a003	CHEBI:15377	pathwaymech:consumes	WikiPathways:WP296/bec38	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML e42b8 connects normalized CHEBI:15377 as an input of interaction bec38."", ""source_locator"": ""/Pathway/Interaction[@GraphId='e42b8']/Graphics; /Pathway/DataNode[@GraphId='f5459']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-21_9155a42ea67b	CHEBI:15377	pathwaymech:consumes	WikiPathways:WP296/id21c76d83	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML f99c8 connects normalized CHEBI:15377 as an input of interaction id21c76d83."", ""source_locator"": ""/Pathway/Interaction[@GraphId='f99c8']/Graphics; /Pathway/DataNode[@GraphId='a6e5e']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-22_5bfc4955b3c2	WikiPathways:WP296/id892d5e82	pathwaymech:produces	CHEBI:15346	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id223de00c connects normalized CHEBI:15346 as an output of interaction id892d5e82."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id223de00c']/Graphics; /Pathway/DataNode[@GraphId='c19']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-23_c0fdc4593d15	WikiPathways:WP296/id892d5e82	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id223de00c connects normalized CHEBI:15378 as an output of interaction id892d5e82."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id223de00c']/Graphics; /Pathway/DataNode[@GraphId='d16c3']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-24_bea8a16950b2	SGD:S000003736	pathwaymech:catalyzes	WikiPathways:WP296/id718be16e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id22686f56 connects normalized SGD:S000003736 as a catalyst of interaction id718be16e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id22686f56']/Graphics; /Pathway/DataNode[@GraphId='e64']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-25_3181d86fbf97	SGD:S000004295	pathwaymech:catalyzes	WikiPathways:WP296/id718be16e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id22686f56 connects normalized SGD:S000004295 as a catalyst of interaction id718be16e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id22686f56']/Graphics; /Pathway/DataNode[@GraphId='eb5']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-26_215f76a04998	WikiPathways:WP296/idaf5b761e	pathwaymech:produces	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id262ffb89 connects normalized CHEBI:30616 as an output of interaction idaf5b761e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id262ffb89']/Graphics; /Pathway/DataNode[@GraphId='be8']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-27_59f021ed2c99	WikiPathways:WP296/idaf5b761e	pathwaymech:produces	CHEBI:15346	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id262ffb89 connects normalized CHEBI:15346 as an output of interaction idaf5b761e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id262ffb89']/Graphics; /Pathway/DataNode[@GraphId='e00']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-28_23cb9caa57bf	SGD:S000005284	pathwaymech:catalyzes	WikiPathways:WP296/id892d5e82	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id45ff05f2 connects normalized SGD:S000005284 as a catalyst of interaction id892d5e82."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id45ff05f2']/Graphics; /Pathway/DataNode[@GraphId='af1']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-29_ba6c658e9610	SGD:S000000598	pathwaymech:catalyzes	WikiPathways:WP296/id892d5e82	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id45ff05f2 connects normalized SGD:S000000598 as a catalyst of interaction id892d5e82."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id45ff05f2']/Graphics; /Pathway/DataNode[@GraphId='c15']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-30_b762ca527beb	SGD:S000006205	pathwaymech:catalyzes	WikiPathways:WP296/id892d5e82	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id45ff05f2 connects normalized SGD:S000006205 as a catalyst of interaction id892d5e82."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id45ff05f2']/Graphics; /Pathway/DataNode[@GraphId='eb6']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-31_dd2d54ce0e78	SGD:S000004982	pathwaymech:enables	WikiPathways:WP296/ida3b8a465	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id535a2a81 connects normalized SGD:S000004982 as an enabling enzyme component of interaction ida3b8a465."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id535a2a81']/Graphics; /Pathway/DataNode[@GraphId='c5f']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-32_c2870d649f68	SGD:S000005662	pathwaymech:enables	WikiPathways:WP296/ida3b8a465	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id535a2a81 connects normalized SGD:S000005662 as an enabling enzyme component of interaction ida3b8a465."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id535a2a81']/Graphics; /Pathway/DataNode[@GraphId='e80']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-33_dfb9ad71d413	SGD:S000005668	pathwaymech:enables	WikiPathways:WP296/idaf5b761e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id649fabcc connects normalized SGD:S000005668 as an enabling enzyme component of interaction idaf5b761e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id649fabcc']/Graphics; /Pathway/DataNode[@GraphId='a05']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-34_9973f1ff76a9	SGD:S000003476	pathwaymech:enables	WikiPathways:WP296/idaf5b761e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id649fabcc connects normalized SGD:S000003476 as an enabling enzyme component of interaction idaf5b761e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id649fabcc']/Graphics; /Pathway/DataNode[@GraphId='ca2']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-35_72324839c0a7	CHEBI:57540	pathwaymech:consumes	WikiPathways:WP296/c084d	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id9381d0ea connects normalized CHEBI:57540 as an input of interaction c084d."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id9381d0ea']/Graphics; /Pathway/DataNode[@GraphId='aaa85']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-36_4629f1d1450d	SGD:S000001624	pathwaymech:enables	WikiPathways:WP296/b7797	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id9d770d61 connects normalized SGD:S000001624 as an enabling enzyme component of interaction b7797."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id9d770d61']/Graphics; /Pathway/DataNode[@GraphId='b23']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-37_7463b637fd05	SGD:S000001631	pathwaymech:enables	WikiPathways:WP296/b7797	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id9d770d61 connects normalized SGD:S000001631 as an enabling enzyme component of interaction b7797."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id9d770d61']/Graphics; /Pathway/DataNode[@GraphId='bcd']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-38_af79a1a4911d	SGD:S000002585	pathwaymech:enables	WikiPathways:WP296/b7797	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id9d770d61 connects normalized SGD:S000002585 as an enabling enzyme component of interaction b7797."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id9d770d61']/Graphics; /Pathway/DataNode[@GraphId='e8a']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-39_9fad7cd1ef9b	SGD:S000003964	pathwaymech:enables	WikiPathways:WP296/b7797	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML id9d770d61 connects normalized SGD:S000003964 as an enabling enzyme component of interaction b7797."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id9d770d61']/Graphics; /Pathway/DataNode[@GraphId='f57']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-40_b5fae5b931c4	CHEBI:15351	pathwaymech:consumes	WikiPathways:WP296/id892d5e82	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML ida4bd3f73 connects normalized CHEBI:15351 as an input of interaction id892d5e82."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ida4bd3f73']/Graphics; /Pathway/DataNode[@GraphId='c81']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-41_2f3d09b60f31	CHEBI:15377	pathwaymech:consumes	WikiPathways:WP296/id892d5e82	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML ida4bd3f73 connects normalized CHEBI:15377 as an input of interaction id892d5e82."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ida4bd3f73']/Graphics; /Pathway/DataNode[@GraphId='aa687']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-42_3b8411718a94	SGD:S000005486	pathwaymech:catalyzes	WikiPathways:WP296/c084d	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML ida80523b connects normalized SGD:S000005486 as a catalyst of interaction c084d."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ida80523b']/Graphics; /Pathway/DataNode[@GraphId='afc']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-43_6c7561e37a40	SGD:S000001568	pathwaymech:catalyzes	WikiPathways:WP296/c084d	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML ida80523b connects normalized SGD:S000001568 as a catalyst of interaction c084d."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ida80523b']/Graphics; /Pathway/DataNode[@GraphId='bda']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-44_6ca58feff289	SGD:S000002236	pathwaymech:catalyzes	WikiPathways:WP296/c084d	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML ida80523b connects normalized SGD:S000002236 as a catalyst of interaction c084d."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ida80523b']/Graphics; /Pathway/DataNode[@GraphId='edb']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-45_25004fb03476	SGD:S000006183	pathwaymech:catalyzes	WikiPathways:WP296/bec38	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML idab038033 connects normalized SGD:S000006183 as a catalyst of interaction bec38."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idab038033']/Graphics; /Pathway/DataNode[@GraphId='d74']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-46_de010a5edee3	CHEBI:52971	pathwaymech:consumes	WikiPathways:WP296/b7797	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML idabc4f331 connects normalized CHEBI:52971 as an input of interaction b7797."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idabc4f331']/Graphics; /Pathway/DataNode[@GraphId='a7e']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-47_d66c459bfd7b	CHEBI:456216	pathwaymech:consumes	WikiPathways:WP296/idaf5b761e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML idb56de142 connects normalized CHEBI:456216 as an input of interaction idaf5b761e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idb56de142']/Graphics; /Pathway/DataNode[@GraphId='a89']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-48_8db994098121	CHEBI:43474	pathwaymech:consumes	WikiPathways:WP296/idaf5b761e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML idb56de142 connects normalized CHEBI:43474 as an input of interaction idaf5b761e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idb56de142']/Graphics; /Pathway/DataNode[@GraphId='f96']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-49_0d998da757bf	CHEBI:57540	pathwaymech:consumes	WikiPathways:WP296/id238f9689	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML idb9cd3a1e connects normalized CHEBI:57540 as an input of interaction id238f9689."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idb9cd3a1e']/Graphics; /Pathway/DataNode[@GraphId='aa36a']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-50_5089e9faf665	CHEBI:15346	pathwaymech:consumes	WikiPathways:WP296/id238f9689	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML idb9cd3a1e connects normalized CHEBI:15346 as an input of interaction id238f9689."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idb9cd3a1e']/Graphics; /Pathway/DataNode[@GraphId='b80e7']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-51_0134b69f14f3	SGD:S000004295	pathwaymech:catalyzes	WikiPathways:WP296/id21c76d83	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML idc9944f47 connects normalized SGD:S000004295 as a catalyst of interaction id21c76d83."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idc9944f47']/Graphics; /Pathway/DataNode[@GraphId='c39']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-52_f7c8436af7bd	CHEBI:57540	pathwaymech:consumes	WikiPathways:WP296/ida3b8a465	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML idd2c371cf connects normalized CHEBI:57540 as an input of interaction ida3b8a465."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idd2c371cf']/Graphics; /Pathway/DataNode[@GraphId='f2838']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-53_f0ef74f7c76a	WikiPathways:WP296/id238f9689	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML iddb7a89c2 connects normalized CHEBI:16526 as an output of interaction id238f9689."", ""source_locator"": ""/Pathway/Interaction[@GraphId='iddb7a89c2']/Graphics; /Pathway/DataNode[@GraphId='bb18d']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-54_73edaef9de80	SGD:S000001387	pathwaymech:enables	WikiPathways:WP296/id238f9689	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML iddbe3f305 connects normalized SGD:S000001387 as an enabling enzyme component of interaction id238f9689."", ""source_locator"": ""/Pathway/Interaction[@GraphId='iddbe3f305']/Graphics; /Pathway/DataNode[@GraphId='efb']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-55_7eee50d34828	SGD:S000002555	pathwaymech:enables	WikiPathways:WP296/id238f9689	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML iddbe3f305 connects normalized SGD:S000002555 as an enabling enzyme component of interaction id238f9689."", ""source_locator"": ""/Pathway/Interaction[@GraphId='iddbe3f305']/Graphics; /Pathway/DataNode[@GraphId='f0f']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-56_3b4840d8ead2	SGD:S000001876	pathwaymech:enables	WikiPathways:WP296/id238f9689	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML iddbe3f305 connects normalized SGD:S000001876 as an enabling enzyme component of interaction id238f9689."", ""source_locator"": ""/Pathway/Interaction[@GraphId='iddbe3f305']/Graphics; /Pathway/DataNode[@GraphId='dd9dc']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-57_a8518b8ec5de	WikiPathways:WP296/ida3b8a465	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML ided1baecb connects normalized CHEBI:16526 as an output of interaction ida3b8a465."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ided1baecb']/Graphics; /Pathway/DataNode[@GraphId='dcc2e']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-58_51184797ffe5	WikiPathways:WP296/c084d	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML idfe360565 connects normalized CHEBI:15378 as an output of interaction c084d."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idfe360565']/Graphics; /Pathway/DataNode[@GraphId='ee3bd']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_causal-review-59_130cf6bcf209	WikiPathways:WP296/b7797	pathwaymech:produces	CHEBI:52970	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP296		"[{""reference_id"": ""WikiPathways:WP296"", ""source_assertion"": ""GPML f1909 connects normalized CHEBI:52970 as an output of interaction b7797."", ""source_locator"": ""/Pathway/Interaction[@GraphId='f1909']/Graphics; /Pathway/DataNode[@GraphId='e4bd2']""}]"	"[{""id"": ""WikiPathways:WP296"", ""source_sha256"": ""07c8681924ab58954024fd265e31b48aa5bcd0827b2e58ee78cc09dfbb2c435a"", ""source_version"": ""WP296_r20260922081654"", ""title"": ""WP296 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP296/WP296.gpml""}]"	""
pathwaymech:WikiPathways_WP296_cofactor-dee09db8b42c_d14d737990c8	SGD:S000001624	pathwaymech:has_cofactor	CHEBI:30413	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P33421	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified The heme is bound between the two transmembrane subunits.	"[{""reference_id"": ""UniProtKB:P33421"", ""source_assertion"": ""UniProtKB:P33421 annotates CHEBI:30413 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1091/comments/0/cofactors/0; /results/1091/comments/0/note""}, {""reference_id"": ""UniProtKB:P33421"", ""source_assertion"": ""UniProtKB:P33421 has the exact SGD cross-reference SGD:S000001624."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1091/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P33421"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P33421 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP296_cofactor-7123993ef776_8dd45584f40e	SGD:S000001631	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q00711	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q0QF01)	"[{""reference_id"": ""UniProtKB:Q00711"", ""source_assertion"": ""UniProtKB:Q00711 annotates CHEBI:57692 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2374/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:Q00711"", ""source_assertion"": ""UniProtKB:Q00711 has the exact SGD cross-reference SGD:S000001631."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2374/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q00711"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB Q00711 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP296_cofactor-59597f700ba3_be8ef32e57d6	SGD:S000004295	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P19414	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:27738674) Binds 1 [4Fe-4S] cluster per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P20004)	"[{""reference_id"": ""UniProtKB:P19414"", ""source_assertion"": ""UniProtKB:P19414 annotates CHEBI:49883 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/497/comments/0/cofactors/0; /results/497/comments/0/note""}, {""reference_id"": ""UniProtKB:P19414"", ""source_assertion"": ""UniProtKB:P19414 has the exact SGD cross-reference SGD:S000004295."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/497/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P19414"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P19414 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP296_cofactor-4786f448cdc0_c232ae48c349	SGD:S000004982	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P28834	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) or Mn(2+) ion per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P28834"", ""source_assertion"": ""UniProtKB:P28834 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/803/comments/0/cofactors/0; /results/803/comments/0/note""}, {""reference_id"": ""UniProtKB:P28834"", ""source_assertion"": ""UniProtKB:P28834 has the exact SGD cross-reference SGD:S000004982."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/803/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P28834"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P28834 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP296_cofactor-f804798aec96_45e51f8fc81e	SGD:S000004982	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P28834	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) or Mn(2+) ion per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P28834"", ""source_assertion"": ""UniProtKB:P28834 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/803/comments/0/cofactors/1; /results/803/comments/0/note""}, {""reference_id"": ""UniProtKB:P28834"", ""source_assertion"": ""UniProtKB:P28834 has the exact SGD cross-reference SGD:S000004982."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/803/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P28834"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P28834 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP296_cofactor-22b372f7f698_e30667bc44ea	SGD:S000003476	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53312	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03219) Binds 1 Mg(2+) ion per subunit. UniProt note evidence: ECO:0000255 (HAMAP-Rule:MF_03219)	"[{""reference_id"": ""UniProtKB:P53312"", ""source_assertion"": ""UniProtKB:P53312 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3976/comments/0/cofactors/0; /results/3976/comments/0/note""}, {""reference_id"": ""UniProtKB:P53312"", ""source_assertion"": ""UniProtKB:P53312 has the exact SGD cross-reference SGD:S000003476."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3976/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53312"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P53312 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP296_cofactor-481201c433a2_8d20d5ab0979	SGD:S000003736	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P39533	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P20004) Binds 1 [4Fe-4S] cluster per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P20004)	"[{""reference_id"": ""UniProtKB:P39533"", ""source_assertion"": ""UniProtKB:P39533 annotates CHEBI:49883 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1568/comments/0/cofactors/0; /results/1568/comments/0/note""}, {""reference_id"": ""UniProtKB:P39533"", ""source_assertion"": ""UniProtKB:P39533 has the exact SGD cross-reference SGD:S000003736."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1568/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P39533"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P39533 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP296_cofactor-111ed2fc38aa_5f2ce70dc71d	SGD:S000005662	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P28241	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) or Mn(2+) ion per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P28241"", ""source_assertion"": ""UniProtKB:P28241 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/784/comments/0/cofactors/0; /results/784/comments/0/note""}, {""reference_id"": ""UniProtKB:P28241"", ""source_assertion"": ""UniProtKB:P28241 has the exact SGD cross-reference SGD:S000005662."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/784/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P28241"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P28241 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP296_cofactor-4bd632d5315d_91267bb20f66	SGD:S000005662	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P28241	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) or Mn(2+) ion per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P28241"", ""source_assertion"": ""UniProtKB:P28241 annotates CHEBI:29035 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/784/comments/0/cofactors/1; /results/784/comments/0/note""}, {""reference_id"": ""UniProtKB:P28241"", ""source_assertion"": ""UniProtKB:P28241 has the exact SGD cross-reference SGD:S000005662."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/784/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P28241"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P28241 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP296_cofactor-5f30756bfde6_185ae3a0f821	SGD:S000001387	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P20967	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P20967"", ""source_assertion"": ""UniProtKB:P20967 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/538/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P20967"", ""source_assertion"": ""UniProtKB:P20967 has the exact SGD cross-reference SGD:S000001387."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/538/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P20967"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P20967 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP296_cofactor-d9b5303dafb2_8993916a8f71	SGD:S000001387	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P20967	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q02218)	"[{""reference_id"": ""UniProtKB:P20967"", ""source_assertion"": ""UniProtKB:P20967 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/538/comments/0/cofactors/1""}, {""reference_id"": ""UniProtKB:P20967"", ""source_assertion"": ""UniProtKB:P20967 has the exact SGD cross-reference SGD:S000001387."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/538/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P20967"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P20967 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP296_cofactor-81ab307524ef_960cf832f8c0	SGD:S000002555	pathwaymech:has_cofactor	CHEBI:83088	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P19262	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The source describes a covalently attached cofactor moiety. Keep that bound-state qualification; no free cosubstrate consumption is inferred. UniProt evidence: not specified Binds 1 lipoyl cofactor covalently.	"[{""reference_id"": ""UniProtKB:P19262"", ""source_assertion"": ""UniProtKB:P19262 annotates CHEBI:83088 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/494/comments/0/cofactors/0; /results/494/comments/0/note""}, {""reference_id"": ""UniProtKB:P19262"", ""source_assertion"": ""UniProtKB:P19262 has the exact SGD cross-reference SGD:S000002555."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/494/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P19262"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P19262 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP296_cofactor-da8e0c6faf5f_f8e2873d1ffd	SGD:S000003964	pathwaymech:has_cofactor	CHEBI:190135	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P21801	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 [2Fe-2S] cluster. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P21801"", ""source_assertion"": ""UniProtKB:P21801 annotates CHEBI:190135 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/560/comments/0/cofactors/0; /results/560/comments/0/note""}, {""reference_id"": ""UniProtKB:P21801"", ""source_assertion"": ""UniProtKB:P21801 has the exact SGD cross-reference SGD:S000003964."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/560/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P21801"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P21801 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP296_cofactor-9c928a783308_4e1fb8ed4298	SGD:S000003964	pathwaymech:has_cofactor	CHEBI:21137	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P21801	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 [3Fe-4S] cluster. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P21801"", ""source_assertion"": ""UniProtKB:P21801 annotates CHEBI:21137 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/560/comments/1/cofactors/0; /results/560/comments/1/note""}, {""reference_id"": ""UniProtKB:P21801"", ""source_assertion"": ""UniProtKB:P21801 has the exact SGD cross-reference SGD:S000003964."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/560/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P21801"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P21801 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP296_cofactor-63ca2a3a3c11_afbbeb4d686e	SGD:S000003964	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P21801	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 [4Fe-4S] cluster. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P21801"", ""source_assertion"": ""UniProtKB:P21801 annotates CHEBI:49883 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/560/comments/2/cofactors/0; /results/560/comments/2/note""}, {""reference_id"": ""UniProtKB:P21801"", ""source_assertion"": ""UniProtKB:P21801 has the exact SGD cross-reference SGD:S000003964."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/560/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P21801"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P21801 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP296_cofactor-4fb48c2e1250_a40245b0b0dc	SGD:S000001876	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09624	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:9538259); ECO:0000269 (Reference:Ref.13) Binds 1 FAD per subunit. UniProt note evidence: ECO:0000269 (PubMed:9538259); ECO:0000269 (Reference:Ref.13)	"[{""reference_id"": ""UniProtKB:P09624"", ""source_assertion"": ""UniProtKB:P09624 annotates CHEBI:57692 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/227/comments/0/cofactors/0; /results/227/comments/0/note""}, {""reference_id"": ""UniProtKB:P09624"", ""source_assertion"": ""UniProtKB:P09624 has the exact SGD cross-reference SGD:S000001876."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/227/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P09624"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P09624 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-001_4df186ad24f5	gomodel:DIHYDROFOLATESYNTH-RXN	RO:0002234	CHEBI:57451	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATESYNTH-RXN RO:0002234 gomodel:CHEBI_57451_DIHYDROFOLATESYNTH-RXN."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/0; endpoint types: /individuals/15/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-002_f9c6a0c05b68	gomodel:DIHYDROFOLATEREDUCT-RXN	BFO:0000050	GO:0046654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATEREDUCT-RXN BFO:0000050 gomodel:YeastPathways_PWY-6614/YeastPathways_PWY-6614."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/1; endpoint types: /individuals/14/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-003_90f7b762da1a	gomodel:DIHYDROFOLATESYNTH-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATESYNTH-RXN RO:0002234 gomodel:CHEBI_456216_DIHYDROFOLATESYNTH-RXN."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/2; endpoint types: /individuals/15/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-004_6cae809f326b	gomodel:DIHYDROFOLATEREDUCT-RXN	RO:0002233	CHEBI:57451	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATEREDUCT-RXN RO:0002233 gomodel:CHEBI_57451_DIHYDROFOLATEREDUCT-RXN."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/3; endpoint types: /individuals/14/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-006_e3c60ac5e42a	gomodel:H2PTEROATESYNTH-RXN	RO:0002413	gomodel:DIHYDROFOLATESYNTH-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:H2PTEROATESYNTH-RXN RO:0002413 gomodel:DIHYDROFOLATESYNTH-RXN."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/5; endpoint types: /individuals/16/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-007_78fb0585fc58	gomodel:DIHYDROFOLATEREDUCT-RXN	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATEREDUCT-RXN RO:0002233 gomodel:CHEBI_57783_DIHYDROFOLATEREDUCT-RXN."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/6; endpoint types: /individuals/14/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-008_f72984d5e182	gomodel:DIHYDROFOLATESYNTH-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATESYNTH-RXN BFO:0000066 gomodel:reaction_DIHYDROFOLATESYNTH-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/7; endpoint types: /individuals/15/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-009_8c0e69ebfddd	gomodel:DIHYDROFOLATESYNTH-RXN	RO:0002233	CHEBI:17839	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATESYNTH-RXN RO:0002233 gomodel:CHEBI_17839_H2PTEROATESYNTH-RXN."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/8; endpoint types: /individuals/15/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-010_cedb3b124a97	gomodel:DIHYDROFOLATEREDUCT-RXN	RO:0002234	CHEBI:67016	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATEREDUCT-RXN RO:0002234 gomodel:YeastPathways_PWY-6614/6690711d00000586."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/9; endpoint types: /individuals/14/type; /individuals/46/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-011_814df66f8a95	gomodel:H2PTEROATESYNTH-RXN	RO:0002233	CHEBI:17836	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:H2PTEROATESYNTH-RXN RO:0002233 gomodel:CHEBI_17836_H2PTEROATESYNTH-RXN."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/10; endpoint types: /individuals/16/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-012_fc96fbde4e25	gomodel:DIHYDROFOLATESYNTH-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATESYNTH-RXN RO:0002233 gomodel:CHEBI_30616_DIHYDROFOLATESYNTH-RXN."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/11; endpoint types: /individuals/15/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-013_8de857ff72ac	gomodel:H2PTEROATESYNTH-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:H2PTEROATESYNTH-RXN RO:0002234 gomodel:CHEBI_29888_H2PTEROATESYNTH-RXN."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/12; endpoint types: /individuals/16/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-014_e9eb17fc9909	gomodel:H2PTEROATESYNTH-RXN	RO:0002233	CHEBI:73083	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:H2PTEROATESYNTH-RXN RO:0002233 gomodel:CHEBI_73083_H2PTEROATESYNTH-RXN."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/13; endpoint types: /individuals/16/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-015_ab537f5c5a1c	gomodel:DIHYDROFOLATEREDUCT-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATEREDUCT-RXN BFO:0000066 gomodel:reaction_DIHYDROFOLATEREDUCT-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/14; endpoint types: /individuals/14/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-016_5552ca15fadc	gomodel:DIHYDROFOLATESYNTH-RXN	RO:0002233	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATESYNTH-RXN RO:0002233 gomodel:CHEBI_29985_DIHYDROFOLATESYNTH-RXN."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/15; endpoint types: /individuals/15/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-017_63ffc62463f5	gomodel:DIHYDROFOLATESYNTH-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATESYNTH-RXN RO:0002234 gomodel:CHEBI_15378_DIHYDROFOLATESYNTH-RXN."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/16; endpoint types: /individuals/15/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-018_06c0f8d400b1	gomodel:H2PTEROATESYNTH-RXN	BFO:0000050	GO:0046654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:H2PTEROATESYNTH-RXN BFO:0000050 gomodel:YeastPathways_PWY-6614/YeastPathways_PWY-6614."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/17; endpoint types: /individuals/16/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-019_b697e1da53db	gomodel:DIHYDROFOLATESYNTH-RXN	BFO:0000050	GO:0046654	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATESYNTH-RXN BFO:0000050 gomodel:YeastPathways_PWY-6614/YeastPathways_PWY-6614."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/18; endpoint types: /individuals/15/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-020_ca9b712969f2	SGD:S000005200	pathwaymech:enables	gomodel:H2PTEROATESYNTH-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:H2PTEROATESYNTH-RXN RO:0002333 gomodel:YNL256W-MONOMER_H2PTEROATESYNTH-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/19; endpoint types: /individuals/16/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-021_fa528d356161	SGD:S000004719	pathwaymech:enables	gomodel:DIHYDROFOLATESYNTH-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATESYNTH-RXN RO:0002333 gomodel:YMR113W-MONOMER_DIHYDROFOLATESYNTH-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/20; endpoint types: /individuals/15/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-022_558ca8e8020d	SGD:S000005762	pathwaymech:enables	gomodel:DIHYDROFOLATEREDUCT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATEREDUCT-RXN RO:0002333 gomodel:YOR236W-MONOMER_DIHYDROFOLATEREDUCT-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/21; endpoint types: /individuals/14/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-023_ef60403b26f5	gomodel:DIHYDROFOLATESYNTH-RXN	RO:0002411	gomodel:DIHYDROFOLATEREDUCT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATESYNTH-RXN RO:0002411 gomodel:DIHYDROFOLATEREDUCT-RXN."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/22; endpoint types: /individuals/15/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-024_ab4f7c78aaa6	gomodel:DIHYDROFOLATEREDUCT-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATEREDUCT-RXN RO:0002233 gomodel:CHEBI_15378_DIHYDROFOLATEREDUCT-RXN."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/23; endpoint types: /individuals/14/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-025_8dc722999f2a	gomodel:DIHYDROFOLATEREDUCT-RXN	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATEREDUCT-RXN RO:0002234 gomodel:CHEBI_58349_DIHYDROFOLATEREDUCT-RXN."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/24; endpoint types: /individuals/14/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-026_8d87fe4e4d89	gomodel:DIHYDROFOLATESYNTH-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:DIHYDROFOLATESYNTH-RXN RO:0002234 gomodel:CHEBI_43474_DIHYDROFOLATESYNTH-RXN."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/25; endpoint types: /individuals/15/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_edge-027_ca4498e7c9ee	gomodel:H2PTEROATESYNTH-RXN	RO:0002234	CHEBI:17839	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6614		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6614"", ""source_assertion"": ""The model asserts gomodel:H2PTEROATESYNTH-RXN RO:0002234 gomodel:CHEBI_17839_H2PTEROATESYNTH-RXN."", ""source_locator"": ""./YeastPathways_PWY-6614.json#/facts/26; endpoint types: /individuals/16/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6614"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6614.json"", ""title"": ""GO-CAM tetrahydrofolate biosynthesis model YeastPathways_PWY-6614"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_location-6a03828d3d37_b734a0f45911	SGD:S000005200	RO:0001025	GO:0031966	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53848	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14576278); ECO:0000269 (PubMed:15169867)	"[{""reference_id"": ""UniProtKB:P53848"", ""source_assertion"": ""UniProtKB:P53848 annotates location Mitochondrion membrane (SL-0171)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2262/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53848"", ""source_assertion"": ""UniProtKB:P53848 has the exact SGD cross-reference SGD:S000005200."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2262/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53848"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53848 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_location-8f45ea4e36ea_9773c6400e22	SGD:S000004719	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12676	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q12676"", ""source_assertion"": ""UniProtKB:Q12676 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/5113/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q12676"", ""source_assertion"": ""UniProtKB:Q12676 has the exact SGD cross-reference SGD:S000004719."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/5113/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q12676"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12676 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6614_cofactor-56d69a096f5c_b1229241b979	SGD:S000005200	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53848	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P0AC13)	"[{""reference_id"": ""UniProtKB:P53848"", ""source_assertion"": ""UniProtKB:P53848 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2262/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P53848"", ""source_assertion"": ""UniProtKB:P53848 has the exact SGD cross-reference SGD:S000005200."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2262/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53848"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53848 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-001_31c31e791655	CHEBI:37565	pathwaymech:consumes	RHEA:17474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17473	Coefficient 1 in the selected biosynthetic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:17473"", ""source_assertion"": ""RHEA:17474 substrates 17473_L contains1 Participant_17473_compound_6355, whose compound is CHEBI:37565."", ""source_locator"": ""http://rdf.rhea-db.org/17474 rh:substrates; http://rdf.rhea-db.org/17473_L rh:contains1 http://rdf.rhea-db.org/Participant_17473_compound_6355; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17473"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:17473 and biosynthetic direction RHEA:17474"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-002_22ea0e024bda	CHEBI:15377	pathwaymech:consumes	RHEA:17474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17473	Coefficient 1 in the selected biosynthetic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:17473"", ""source_assertion"": ""RHEA:17474 substrates 17473_L contains1 Participant_17473_compound_1283, whose compound is CHEBI:15377."", ""source_locator"": ""http://rdf.rhea-db.org/17474 rh:substrates; http://rdf.rhea-db.org/17473_L rh:contains1 http://rdf.rhea-db.org/Participant_17473_compound_1283; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17473"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:17473 and biosynthetic direction RHEA:17474"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-003_0dbb61afab94	RHEA:17474	pathwaymech:produces	CHEBI:58462	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17473	Coefficient 1 in the selected biosynthetic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:17473"", ""source_assertion"": ""RHEA:17474 products 17473_R contains1 Participant_17473_compound_2443, whose compound is CHEBI:58462."", ""source_locator"": ""http://rdf.rhea-db.org/17474 rh:products; http://rdf.rhea-db.org/17473_R rh:contains1 http://rdf.rhea-db.org/Participant_17473_compound_2443; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17473"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:17473 and biosynthetic direction RHEA:17474"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-004_6dbde91d0dce	RHEA:17474	pathwaymech:produces	CHEBI:15740	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17473	Coefficient 1 in the selected biosynthetic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:17473"", ""source_assertion"": ""RHEA:17474 products 17473_R contains1 Participant_17473_compound_3001, whose compound is CHEBI:15740."", ""source_locator"": ""http://rdf.rhea-db.org/17474 rh:products; http://rdf.rhea-db.org/17473_R rh:contains1 http://rdf.rhea-db.org/Participant_17473_compound_3001; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17473"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:17473 and biosynthetic direction RHEA:17474"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-005_c7955e3a86ea	RHEA:17474	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17473	Coefficient 1 in the selected biosynthetic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:17473"", ""source_assertion"": ""RHEA:17474 products 17473_R contains1 Participant_17473_compound_3249, whose compound is CHEBI:15378."", ""source_locator"": ""http://rdf.rhea-db.org/17474 rh:products; http://rdf.rhea-db.org/17473_R rh:contains1 http://rdf.rhea-db.org/Participant_17473_compound_3249; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17473"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:17473 and biosynthetic direction RHEA:17474"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-006_208675ddc65f	CHEBI:58462	pathwaymech:consumes	RHEA:28347	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28346	Coefficient 1 in the selected biosynthetic Rhea direction; exact source charge and stereochemical form. FolX is reversible experimentally; this record selects its monapterin-forming direction.	"[{""reference_id"": ""RHEA:28346"", ""source_assertion"": ""RHEA:28347 substrates 28346_L contains1 Participant_28346_compound_2443, whose compound is CHEBI:58462."", ""source_locator"": ""http://rdf.rhea-db.org/28347 rh:substrates; http://rdf.rhea-db.org/28346_L rh:contains1 http://rdf.rhea-db.org/Participant_28346_compound_2443; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28346"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:28346 and biosynthetic direction RHEA:28347"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-007_25abfc3f0acc	RHEA:28347	pathwaymech:produces	CHEBI:61186	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:28346	Coefficient 1 in the selected biosynthetic Rhea direction; exact source charge and stereochemical form. FolX is reversible experimentally; this record selects its monapterin-forming direction.	"[{""reference_id"": ""RHEA:28346"", ""source_assertion"": ""RHEA:28347 products 28346_R contains1 Participant_28346_compound_6431, whose compound is CHEBI:61186."", ""source_locator"": ""http://rdf.rhea-db.org/28347 rh:products; http://rdf.rhea-db.org/28346_R rh:contains1 http://rdf.rhea-db.org/Participant_28346_compound_6431; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:28346"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:28346 and biosynthetic direction RHEA:28347"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-008_10b7f70f4605	CHEBI:71175	pathwaymech:consumes	RHEA:34848	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34847	Coefficient 1 in the selected biosynthetic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:34847"", ""source_assertion"": ""RHEA:34848 substrates 34847_L contains1 Participant_34847_compound_7636, whose compound is CHEBI:71175."", ""source_locator"": ""http://rdf.rhea-db.org/34848 rh:substrates; http://rdf.rhea-db.org/34847_L rh:contains1 http://rdf.rhea-db.org/Participant_34847_compound_7636; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:34847"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:34847 and biosynthetic direction RHEA:34848"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-009_63bd997bda3a	CHEBI:57783	pathwaymech:consumes	RHEA:34848	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34847	Coefficient 1 in the selected biosynthetic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:34847"", ""source_assertion"": ""RHEA:34848 substrates 34847_L contains1 Participant_34847_compound_3438, whose compound is CHEBI:57783."", ""source_locator"": ""http://rdf.rhea-db.org/34848 rh:substrates; http://rdf.rhea-db.org/34847_L rh:contains1 http://rdf.rhea-db.org/Participant_34847_compound_3438; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:34847"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:34847 and biosynthetic direction RHEA:34848"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-010_df2012c6423c	CHEBI:15378	pathwaymech:consumes	RHEA:34848	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34847	Coefficient 1 in the selected biosynthetic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:34847"", ""source_assertion"": ""RHEA:34848 substrates 34847_L contains1 Participant_34847_compound_3249, whose compound is CHEBI:15378."", ""source_locator"": ""http://rdf.rhea-db.org/34848 rh:substrates; http://rdf.rhea-db.org/34847_L rh:contains1 http://rdf.rhea-db.org/Participant_34847_compound_3249; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:34847"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:34847 and biosynthetic direction RHEA:34848"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-011_8ae5d1ed2b56	RHEA:34848	pathwaymech:produces	CHEBI:71177	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34847	Coefficient 1 in the selected biosynthetic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:34847"", ""source_assertion"": ""RHEA:34848 products 34847_R contains1 Participant_34847_compound_7637, whose compound is CHEBI:71177."", ""source_locator"": ""http://rdf.rhea-db.org/34848 rh:products; http://rdf.rhea-db.org/34847_R rh:contains1 http://rdf.rhea-db.org/Participant_34847_compound_7637; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:34847"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:34847 and biosynthetic direction RHEA:34848"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-012_a342b87067ae	RHEA:34848	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34847	Coefficient 1 in the selected biosynthetic Rhea direction; exact source charge and stereochemical form.	"[{""reference_id"": ""RHEA:34847"", ""source_assertion"": ""RHEA:34848 products 34847_R contains1 Participant_34847_compound_5188, whose compound is CHEBI:58349."", ""source_locator"": ""http://rdf.rhea-db.org/34848 rh:products; http://rdf.rhea-db.org/34847_R rh:contains1 http://rdf.rhea-db.org/Participant_34847_compound_5188; rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:34847"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:34847 and biosynthetic direction RHEA:34848"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-013_8526c07b84a3	MetaCyc:FOLE-CPLX	pathwaymech:catalyzes	RHEA:17474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:FOLE-CPLX|PMID:11087827|UniProtKB:P0A6T5	The experimentally characterized FolE homodecamer catalyzes GTP cyclohydrolase I chemistry. The reviewed catalytic cross-reference has no explicit experimental ECO tag; primary enzyme evidence is cited separately.	"[{""reference_id"": ""MetaCyc:FOLE-CPLX"", ""source_assertion"": ""FOLE-CPLX catalyzes GTP-CYCLOHYDRO-I-ENZRXN, whose reaction is GTP-CYCLOHYDRO-I-RXN."", ""source_locator"": ""Protein[@frameid=\""FOLE-CPLX\""]/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:P0A6T5"", ""source_assertion"": ""The reviewed catalytic-activity comment assigns the GTP cyclohydrolase I equation and RHEA:17473."", ""source_locator"": ""comments[0].reaction; reactionCrossReferences[Rhea]""}, {""reference_id"": ""PMID:11087827"", ""source_assertion"": ""Purified recombinant E. coli GTP cyclohydrolase I showed activity and active-site zinc in the crystallographic and biochemical analysis."", ""source_locator"": ""PMC17616, Results and Discussion, Crystallographic Analysis of eGTP-CH-I Purified in the Absence of Chelating Agents""}]"	"[{""id"": ""MetaCyc:FOLE-CPLX"", ""source_sha256"": ""02a1387ca3463fcdc819710574fdcfaba6688579873fd069a9c172e1333320e8"", ""source_version"": ""MetaCyc 22.5; public getxml export accessed 2026-10-10; digest covers exact XML response"", ""title"": ""MetaCyc FOLE-CPLX native Pathway Tools object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:FOLE-CPLX""}, {""id"": ""PMID:11087827"", ""source_sha256"": ""c19ca35524232472e1074d366912a18bee286c1d089e78072184489bfb850743"", ""source_version"": ""Full primary HTML; exact response digest; DOI 10.1073/pnas.240463497; accessed 2026-10-10"", ""title"": ""Zinc plays a key role in human and bacterial GTP cyclohydrolase I."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC17616/""}, {""id"": ""UniProtKB:P0A6T5"", ""source_sha256"": ""c81d6948a4c2f1043c216c6ff6de92554b2910ffd116c82ba6a1b9eec7ee7918"", ""source_version"": ""UniProt 2026_03; entry version 153; sequence version 2; accessed 2026-10-10"", ""title"": ""GTP cyclohydrolase 1 — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6T5.json""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-014_50bfae1969a4	MetaCyc:FOLXTET-CPLX	pathwaymech:catalyzes	RHEA:28347	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:FOLXTET-CPLX|PMID:9651328|UniProtKB:P0AC19	FolX catalyzes reversible epimerization at side-chain carbon 2′; its monapterin-forming direction is selected here. The catalytic species is the experimentally supported octamer.	"[{""reference_id"": ""MetaCyc:FOLXTET-CPLX"", ""source_assertion"": ""FOLXTET-CPLX catalyzes H2NTPEPIM-ENZRXN and H2NTPEPIM-RXN."", ""source_locator"": ""Protein[@frameid=\""FOLXTET-CPLX\""]/catalyzes/Enzymatic-Reaction/reaction""}, {""reference_id"": ""UniProtKB:P0AC19"", ""source_assertion"": ""CATALYTIC ACTIVITY assigns RHEA:28346, with experimental evidence from PMID 9182560 and 9651328. Source evidence code: ECO:0000269."", ""source_locator"": ""comments[1].reaction; reactionCrossReferences; evidences""}, {""reference_id"": ""PMID:9651328"", ""source_assertion"": ""Recombinant FolX catalyzes carbon 2′ epimerization of dihydroneopterin and dihydromonapterin triphosphates; FolX forms a homooctamer."", ""source_locator"": ""Europe PMC core result[id=9651328].abstractText""}]"	"[{""id"": ""MetaCyc:FOLXTET-CPLX"", ""source_sha256"": ""9cc740d0549ca3c8ea3f18c8b3c69568a2aeeae31c4d4bbccf975cb6ad75afc8"", ""source_version"": ""MetaCyc 22.5; public getxml export accessed 2026-10-10; digest covers exact XML response"", ""title"": ""MetaCyc FOLXTET-CPLX native Pathway Tools object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:FOLXTET-CPLX""}, {""id"": ""PMID:9651328"", ""source_sha256"": ""15d1026bffa483f1a581938170be3b0d34d7d61dc86abfde4f8eb67b43f4ca3d"", ""source_version"": ""Primary abstract in Europe PMC core; digest covers complete 5-paper JSON response, not the individual PubMed page; DOI 10.1074/jbc.273.28.17418; accessed 2026-10-10"", ""title"": ""Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9651328/""}, {""id"": ""UniProtKB:P0AC19"", ""source_sha256"": ""1ea42535c9d7dacc6fe247065d0d53d1615bca6060360b9ebefde0090f6d5fb3"", ""source_version"": ""UniProt 2026_03; entry version 135; sequence version 2; accessed 2026-10-10"", ""title"": ""Dihydroneopterin triphosphate 2'-epimerase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AC19.json""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-015_4c2bd4435a2e	UniProtKB:P0AFS3	pathwaymech:catalyzes	RHEA:34848	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19897652|UniProtKB:P0AFS3	Purified FolM reduces dihydromonapterin with NADPH. The primary assay used 100 µM NADPH, 50 µM pterin, 10 mM beta-mercaptoethanol and 100 mM potassium phosphate pH 6 at 22–23°C. This does not establish the upstream dephosphorylation step or a quinonoid-recycling role.	"[{""reference_id"": ""UniProtKB:P0AFS3"", ""source_assertion"": ""The dihydromonapterin catalytic-activity comment assigns RHEA:34847 and cites PMID 19897652 as experimental evidence. Source evidence code: ECO:0000269."", ""source_locator"": ""comments[2].reaction; reactionCrossReferences; evidences""}, {""quote"": ""NADH could not replace NADPH as the cofactor."", ""reference_id"": ""PMID:19897652"", ""source_locator"": ""PMC2805310, Results, Recombinant FolM has high H2-MPt reductase activity""}, {""reference_id"": ""PMID:19897652"", ""source_assertion"": ""Purified FolM reduces dihydromonapterin; no activity above rearrangement-derived background was detected with quinonoid dihydromonapterin."", ""source_locator"": ""PMC2805310, Materials and Methods (FolM assays); Results/Fig.4""}]"	"[{""id"": ""PMID:19897652"", ""source_sha256"": ""68ab2338bf7b5aaddc524e871c65061800e345948a99211b46e58979e384cfab"", ""source_version"": ""Full primary HTML; exact response digest; DOI 10.1128/jb.01198-09; accessed 2026-10-10"", ""title"": ""FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2805310/""}, {""id"": ""UniProtKB:P0AFS3"", ""source_sha256"": ""587088963abd7a8e80b0c89a62f327dbdc04f7baa88dbbc89d5fdeb7ae35cc40"", ""source_version"": ""UniProt 2026_03; entry version 131; sequence version 1; accessed 2026-10-10"", ""title"": ""Dihydromonapterin reductase — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AFS3.json""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-016_8935cf7614f8	UniProtKB:P0A6T5	BFO:0000050	MetaCyc:FOLE-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:FOLE-CPLX|MetaCyc:GTP-CYCLOHYDRO-I-MONOMER|PMID:12297008	10 identical FolE subunits form the homodecamer.	"[{""reference_id"": ""MetaCyc:FOLE-CPLX"", ""source_assertion"": ""FOLE-CPLX has component GTP-CYCLOHYDRO-I-MONOMER with coefficient 10."", ""source_locator"": ""Protein[@frameid=\""FOLE-CPLX\""]/component""}, {""reference_id"": ""MetaCyc:GTP-CYCLOHYDRO-I-MONOMER"", ""source_assertion"": ""GTP-CYCLOHYDRO-I-MONOMER has a UNIPROT unification cross-reference to P0A6T5."", ""source_locator"": ""Protein[@frameid=\""GTP-CYCLOHYDRO-I-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""PMID:12297008"", ""source_assertion"": ""Biochemical reconstitution and size-exclusion experiments support a pentamer of five dimers."", ""source_locator"": ""Europe PMC core result[id=12297008].abstractText""}]"	"[{""id"": ""MetaCyc:FOLE-CPLX"", ""source_sha256"": ""02a1387ca3463fcdc819710574fdcfaba6688579873fd069a9c172e1333320e8"", ""source_version"": ""MetaCyc 22.5; public getxml export accessed 2026-10-10; digest covers exact XML response"", ""title"": ""MetaCyc FOLE-CPLX native Pathway Tools object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:FOLE-CPLX""}, {""id"": ""MetaCyc:GTP-CYCLOHYDRO-I-MONOMER"", ""source_sha256"": ""6988338efb0309524e58a23f315c10f912adec4eac0c9147bfddb0a36d366f1d"", ""source_version"": ""MetaCyc 22.5; public getxml export accessed 2026-10-10; digest covers exact XML response"", ""title"": ""MetaCyc GTP-CYCLOHYDRO-I-MONOMER native Pathway Tools object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GTP-CYCLOHYDRO-I-MONOMER""}, {""id"": ""PMID:12297008"", ""source_sha256"": ""15d1026bffa483f1a581938170be3b0d34d7d61dc86abfde4f8eb67b43f4ca3d"", ""source_version"": ""Primary abstract in Europe PMC core; digest covers complete 5-paper JSON response, not the individual PubMed page; DOI 10.5483/bmbrep.2002.35.3.255; accessed 2026-10-10"", ""title"": ""Biochemical characterization of oligomerization of Escherichia coli GTP cyclohydrolase I."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/12297008/""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-017_efc43e49b902	UniProtKB:P0AC19	BFO:0000050	MetaCyc:FOLXTET-CPLX	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:FOLXTET-CPLX|MetaCyc:H2NTPEPIM-MONOMER|PMID:10378270|PMID:9182560	8 identical FolX subunits form the homooctamer; the 1997 hydrodynamic hexamer estimate is superseded by 1998 biochemical and 1999 structural evidence.	"[{""reference_id"": ""MetaCyc:FOLXTET-CPLX"", ""source_assertion"": ""FOLXTET-CPLX has component H2NTPEPIM-MONOMER with coefficient 8."", ""source_locator"": ""Protein[@frameid=\""FOLXTET-CPLX\""]/component""}, {""reference_id"": ""MetaCyc:H2NTPEPIM-MONOMER"", ""source_assertion"": ""H2NTPEPIM-MONOMER has a UNIPROT unification cross-reference to P0AC19."", ""source_locator"": ""Protein[@frameid=\""H2NTPEPIM-MONOMER\""]/dblink[dblink-db=\""UNIPROT\""]""}, {""reference_id"": ""PMID:10378270"", ""source_assertion"": ""The 2.9 Å crystal structure shows a torus-shaped D4-symmetric homooctamer formed by two head-to-head tetramers."", ""source_locator"": ""Europe PMC core result[id=10378270].abstractText""}, {""reference_id"": ""PMID:9182560"", ""source_assertion"": ""The 1997 study inferred a probable homohexamer from apparent molecular masses 82.6 kDa (native) and 13.7 kDa (subunit); this is a conflicting historical estimate, not the selected assembly."", ""source_locator"": ""Europe PMC core result[id=9182560].abstractText""}]"	"[{""id"": ""MetaCyc:FOLXTET-CPLX"", ""source_sha256"": ""9cc740d0549ca3c8ea3f18c8b3c69568a2aeeae31c4d4bbccf975cb6ad75afc8"", ""source_version"": ""MetaCyc 22.5; public getxml export accessed 2026-10-10; digest covers exact XML response"", ""title"": ""MetaCyc FOLXTET-CPLX native Pathway Tools object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:FOLXTET-CPLX""}, {""id"": ""MetaCyc:H2NTPEPIM-MONOMER"", ""source_sha256"": ""f4325f3a4d35c52c9fc34261feeccffeaa798a30645e9d53208044d0d7f1e018"", ""source_version"": ""MetaCyc 22.5; public getxml export accessed 2026-10-10; digest covers exact XML response"", ""title"": ""MetaCyc H2NTPEPIM-MONOMER native Pathway Tools object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:H2NTPEPIM-MONOMER""}, {""id"": ""PMID:10378270"", ""source_sha256"": ""15d1026bffa483f1a581938170be3b0d34d7d61dc86abfde4f8eb67b43f4ca3d"", ""source_version"": ""Primary abstract in Europe PMC core; digest covers complete 5-paper JSON response, not the individual PubMed page; DOI 10.1016/s0969-2126(99)80067-7; accessed 2026-10-10"", ""title"": ""Crystal structure of 7,8-dihydroneopterin triphosphate epimerase."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/10378270/""}, {""id"": ""PMID:9182560"", ""source_sha256"": ""15d1026bffa483f1a581938170be3b0d34d7d61dc86abfde4f8eb67b43f4ca3d"", ""source_version"": ""Primary abstract in Europe PMC core; digest covers complete 5-paper JSON response, not the individual PubMed page; DOI 10.1074/jbc.272.24.15323; accessed 2026-10-10"", ""title"": ""Purification, cloning, and functional expression of dihydroneopterin triphosphate 2'-epimerase from Escherichia coli."", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/9182560/""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-018_5709c3dbb576	MetaCyc:FOLE-CPLX	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11087827|UniProtKB:P0A6T5	Catalytically essential zinc is bound at each FolE active site; the E. coli study measured 0.9 ± 0.1 zinc ions per subunit. This is enzyme-bound cofactor evidence, not merely a metal added to assay buffer.	"[{""reference_id"": ""PMID:11087827"", ""source_assertion"": ""Chemical analysis of the E. coli protein measured 0.9 ± 0.1 zinc ions per subunit, and the structure localized the bound metal to the active site."", ""source_locator"": ""PMC17616, Results and Discussion, Crystallographic Analysis of eGTP-CH-I Purified in the Absence of Chelating Agents""}, {""reference_id"": ""UniProtKB:P0A6T5"", ""source_assertion"": ""Binding-site features identify Zn(2+) with ChEBI:CHEBI:29105; the features do not supply an explicit ECO tag."", ""source_locator"": ""features[type=\""Binding site\""].ligand.id""}]"	"[{""id"": ""PMID:11087827"", ""source_sha256"": ""c19ca35524232472e1074d366912a18bee286c1d089e78072184489bfb850743"", ""source_version"": ""Full primary HTML; exact response digest; DOI 10.1073/pnas.240463497; accessed 2026-10-10"", ""title"": ""Zinc plays a key role in human and bacterial GTP cyclohydrolase I."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC17616/""}, {""id"": ""UniProtKB:P0A6T5"", ""source_sha256"": ""c81d6948a4c2f1043c216c6ff6de92554b2910ffd116c82ba6a1b9eec7ee7918"", ""source_version"": ""UniProt 2026_03; entry version 153; sequence version 2; accessed 2026-10-10"", ""title"": ""GTP cyclohydrolase 1 — reviewed UniProtKB record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6T5.json""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-019_1715320652a3	RHEA:17474	BFO:0000050	MetaCyc:PWY0-1433	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:GTP-CYCLOHYDRO-I-RXN|MetaCyc:PWY0-1433|RHEA:17473	A supported reaction module in the native pathway. Membership does not assert that the omitted dephosphorylation has been mechanistically resolved.	"[{""reference_id"": ""MetaCyc:PWY0-1433"", ""source_assertion"": ""PWY0-1433 explicitly lists GTP-CYCLOHYDRO-I-RXN as a pathway reaction."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1433\""]/reaction-list""}, {""reference_id"": ""MetaCyc:GTP-CYCLOHYDRO-I-RXN"", ""source_assertion"": ""GTP-CYCLOHYDRO-I-RXN has a Rhea unification cross-reference to 17473."", ""source_locator"": ""Reaction[@frameid=\""GTP-CYCLOHYDRO-I-RXN\""]/dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:17473"", ""source_assertion"": ""Master RHEA:17473 has directional reaction RHEA:17474."", ""source_locator"": ""http://rdf.rhea-db.org/17473 rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:GTP-CYCLOHYDRO-I-RXN"", ""source_sha256"": ""d845a7ac9a12492f42c17057a4344c552edfb3bf9ad3ab76cf60871ce61962b6"", ""source_version"": ""MetaCyc 22.5; public getxml export accessed 2026-10-10; digest covers exact XML response"", ""title"": ""MetaCyc GTP-CYCLOHYDRO-I-RXN native Pathway Tools object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:GTP-CYCLOHYDRO-I-RXN""}, {""id"": ""MetaCyc:PWY0-1433"", ""source_sha256"": ""7c8efe87343da2bf566f4e7cedb6c6eca964e9eb12b6a83f5fc94cc86e205280"", ""source_version"": ""MetaCyc 22.5; public getxml export accessed 2026-10-10; digest covers exact XML response"", ""title"": ""MetaCyc PWY0-1433 native Pathway Tools object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1433""}, {""id"": ""RHEA:17473"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:17473 and biosynthetic direction RHEA:17474"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-020_44e416e78d25	RHEA:28347	BFO:0000050	MetaCyc:PWY0-1433	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:H2NTPEPIM-RXN|MetaCyc:PWY0-1433|RHEA:28346	A supported reaction module in the native pathway. Membership does not assert that the omitted dephosphorylation has been mechanistically resolved.	"[{""reference_id"": ""MetaCyc:PWY0-1433"", ""source_assertion"": ""PWY0-1433 explicitly lists H2NTPEPIM-RXN as a pathway reaction."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1433\""]/reaction-list""}, {""reference_id"": ""MetaCyc:H2NTPEPIM-RXN"", ""source_assertion"": ""H2NTPEPIM-RXN has a Rhea unification cross-reference to 28349."", ""source_locator"": ""Reaction[@frameid=\""H2NTPEPIM-RXN\""]/dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:28346"", ""source_assertion"": ""Master RHEA:28346 has directional reaction RHEA:28347 and bidirectional reaction RHEA:28349, the latter being the native MetaCyc cross-reference."", ""source_locator"": ""http://rdf.rhea-db.org/28346 rh:directionalReaction; rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:H2NTPEPIM-RXN"", ""source_sha256"": ""cb71c16f52bfa38dddc60b31c1b57a1f97b8f3f878e8eb2fd94f0a4ce68006cd"", ""source_version"": ""MetaCyc 22.5; public getxml export accessed 2026-10-10; digest covers exact XML response"", ""title"": ""MetaCyc H2NTPEPIM-RXN native Pathway Tools object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:H2NTPEPIM-RXN""}, {""id"": ""MetaCyc:PWY0-1433"", ""source_sha256"": ""7c8efe87343da2bf566f4e7cedb6c6eca964e9eb12b6a83f5fc94cc86e205280"", ""source_version"": ""MetaCyc 22.5; public getxml export accessed 2026-10-10; digest covers exact XML response"", ""title"": ""MetaCyc PWY0-1433 native Pathway Tools object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1433""}, {""id"": ""RHEA:28346"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:28346 and biosynthetic direction RHEA:28347"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-021_3bb32ae894ca	RHEA:34848	BFO:0000050	MetaCyc:PWY0-1433	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY0-1433|MetaCyc:RXN0-6367|RHEA:34847	A supported reaction module in the native pathway. Membership does not assert that the omitted dephosphorylation has been mechanistically resolved.	"[{""reference_id"": ""MetaCyc:PWY0-1433"", ""source_assertion"": ""PWY0-1433 explicitly lists RXN0-6367 as a pathway reaction."", ""source_locator"": ""Pathway[@frameid=\""PWY0-1433\""]/reaction-list""}, {""reference_id"": ""MetaCyc:RXN0-6367"", ""source_assertion"": ""RXN0-6367 has a Rhea unification cross-reference to 34847."", ""source_locator"": ""Reaction[@frameid=\""RXN0-6367\""]/dblink[dblink-db=\""RHEA\""]""}, {""reference_id"": ""RHEA:34847"", ""source_assertion"": ""Master RHEA:34847 has directional reaction RHEA:34848."", ""source_locator"": ""http://rdf.rhea-db.org/34847 rh:directionalReaction""}]"	"[{""id"": ""MetaCyc:PWY0-1433"", ""source_sha256"": ""7c8efe87343da2bf566f4e7cedb6c6eca964e9eb12b6a83f5fc94cc86e205280"", ""source_version"": ""MetaCyc 22.5; public getxml export accessed 2026-10-10; digest covers exact XML response"", ""title"": ""MetaCyc PWY0-1433 native Pathway Tools object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY0-1433""}, {""id"": ""MetaCyc:RXN0-6367"", ""source_sha256"": ""35f144bb90de731ad2f23e03c0a64a38027c1e6ccb1844163fce01e2b02e79ff"", ""source_version"": ""MetaCyc 22.5; public getxml export accessed 2026-10-10; digest covers exact XML response"", ""title"": ""MetaCyc RXN0-6367 native Pathway Tools object"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-6367""}, {""id"": ""RHEA:34847"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:34847 and biosynthetic direction RHEA:34848"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-022_1b64fcc33739	RHEA:17474	RO:0002413	RHEA:28347	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17473|RHEA:28346	FolE produces the exact dihydroneopterin-triphosphate form consumed by FolX. This connects only these two experimentally supported reactions; no edge connects FolX to FolM.	"[{""reference_id"": ""RHEA:17473"", ""source_assertion"": ""RHEA:17474 produces CHEBI:58462."", ""source_locator"": ""http://rdf.rhea-db.org/17474 rh:products; rh:contains1/rh:compound/rh:accession""}, {""reference_id"": ""RHEA:28346"", ""source_assertion"": ""RHEA:28347 consumes CHEBI:58462."", ""source_locator"": ""http://rdf.rhea-db.org/28347 rh:substrates; rh:contains1/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:17473"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:17473 and biosynthetic direction RHEA:17474"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:28346"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea 142, 2026-09-02; digest covers complete compressed official RDF"", ""title"": ""RHEA:28346 and biosynthetic direction RHEA:28347"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-023_dae3a82b697f	UniProtKB:P0AC19	pathwaymech:enables	MetaCyc:PWY0-1433	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19897652	Genetic evidence supports the role of folX in the established pathway; it neither identifies the intervening phosphatase nor proves its net phosphate-release stoichiometry.	"[{""reference_id"": ""PMID:19897652"", ""source_assertion"": ""Deleting folX abolished heterologous PhhA/PhhB rescue of tyrosine auxotrophy in E. coli K-12 JP2255, and plasmid expression of the deleted gene restored rescue."", ""source_locator"": ""PMC2805310, Methods (E. coli deletions); Results/Fig.3D""}]"	"[{""id"": ""PMID:19897652"", ""source_sha256"": ""68ab2338bf7b5aaddc524e871c65061800e345948a99211b46e58979e384cfab"", ""source_version"": ""Full primary HTML; exact response digest; DOI 10.1128/jb.01198-09; accessed 2026-10-10"", ""title"": ""FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2805310/""}]"	""
pathwaymech:MetaCyc_PWY0-1433_monapterin-edge-024_081d9695a207	UniProtKB:P0AFS3	pathwaymech:enables	MetaCyc:PWY0-1433	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19897652	Genetic evidence supports the role of folM in the established pathway; it neither identifies the intervening phosphatase nor proves its net phosphate-release stoichiometry.	"[{""reference_id"": ""PMID:19897652"", ""source_assertion"": ""Deleting folM abolished heterologous PhhA/PhhB rescue of tyrosine auxotrophy in E. coli K-12 JP2255, and plasmid expression of the deleted gene restored rescue."", ""source_locator"": ""PMC2805310, Methods (E. coli deletions); Results/Fig.3D""}]"	"[{""id"": ""PMID:19897652"", ""source_sha256"": ""68ab2338bf7b5aaddc524e871c65061800e345948a99211b46e58979e384cfab"", ""source_version"": ""Full primary HTML; exact response digest; DOI 10.1128/jb.01198-09; accessed 2026-10-10"", ""title"": ""FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa."", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2805310/""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-001_bdf36c26794a	gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN	RO:0002234	CHEBI:356416	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_356416_5-AMINOLEVULINIC-ACID-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/0; endpoint types: /individuals/50/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-002_31f636a8a015	gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_16526_5-AMINOLEVULINIC-ACID-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/1; endpoint types: /individuals/50/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-003_73a419062964	gomodel:UROGENIIISYN-RXN	RO:0002234	CHEBI:57308	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:UROGENIIISYN-RXN RO:0002234 gomodel:CHEBI_57308_UROGENIIISYN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/2; endpoint types: /individuals/16/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-004_98558a1706e9	SGD:S000002640	pathwaymech:enables	gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN RO:0002333 gomodel:YDR232W-MONOMER_5-AMINOLEVULINIC-ACID-SYNTHASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/3; endpoint types: /individuals/50/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-005_4bf7b6309c86	SGD:S000002364	pathwaymech:enables	gomodel:OHMETHYLBILANESYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:OHMETHYLBILANESYN-RXN RO:0002333 gomodel:YDL205C-MONOMER_OHMETHYLBILANESYN-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/4; endpoint types: /individuals/14/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-007_8e12989d6aac	SGD:S000003008	pathwaymech:enables	gomodel:PORPHOBILSYNTH-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:PORPHOBILSYNTH-RXN RO:0002333 gomodel:YGL040C-MONOMER_PORPHOBILSYNTH-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/6; endpoint types: /individuals/15/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-008_3bd46a06e028	gomodel:UROGENIIISYN-RXN	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:UROGENIIISYN-RXN RO:0002234 gomodel:CHEBI_15377_UROGENIIISYN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/7; endpoint types: /individuals/16/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-009_bee6ef509f4b	gomodel:PORPHOBILSYNTH-RXN	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:PORPHOBILSYNTH-RXN RO:0002234 gomodel:CHEBI_15377_PORPHOBILSYNTH-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/8; endpoint types: /individuals/15/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-010_0c9ae8a972b9	gomodel:UROGENIIISYN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:UROGENIIISYN-RXN BFO:0000066 gomodel:reaction_UROGENIIISYN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/9; endpoint types: /individuals/16/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-011_07d3df0a9b84	gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN	BFO:0000050	GO:0033014	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-50/YeastPathways_PWY3O-50."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/10; endpoint types: /individuals/50/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-012_4ef6822a2a09	gomodel:PORPHOBILSYNTH-RXN	RO:0002234	CHEBI:58126	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:PORPHOBILSYNTH-RXN RO:0002234 gomodel:CHEBI_58126_PORPHOBILSYNTH-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/11; endpoint types: /individuals/15/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-013_807611ffaf39	gomodel:OHMETHYLBILANESYN-RXN	RO:0002233	CHEBI:58126	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:OHMETHYLBILANESYN-RXN RO:0002233 gomodel:CHEBI_58126_PORPHOBILSYNTH-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/12; endpoint types: /individuals/14/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-014_0137874bb97d	gomodel:OHMETHYLBILANESYN-RXN	RO:0002234	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:OHMETHYLBILANESYN-RXN RO:0002234 gomodel:CHEBI_28938_OHMETHYLBILANESYN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/13; endpoint types: /individuals/14/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-015_e4e7be6b2193	gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_15378_5-AMINOLEVULINIC-ACID-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/14; endpoint types: /individuals/50/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-016_c3f1b697ab99	gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN	RO:0002233	CHEBI:57292	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_57292_5-AMINOLEVULINIC-ACID-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/15; endpoint types: /individuals/50/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-017_9ed8fe3780e0	gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN	RO:0002233	CHEBI:57305	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_57305_5-AMINOLEVULINIC-ACID-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/16; endpoint types: /individuals/50/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-018_171e7e25fa81	gomodel:PORPHOBILSYNTH-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:PORPHOBILSYNTH-RXN BFO:0000066 gomodel:reaction_PORPHOBILSYNTH-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/17; endpoint types: /individuals/15/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-019_03b55a0ce287	gomodel:OHMETHYLBILANESYN-RXN	BFO:0000050	GO:0033014	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:OHMETHYLBILANESYN-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-50/YeastPathways_PWY3O-50."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/18; endpoint types: /individuals/14/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-020_a5a33c981a26	gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_57287_5-AMINOLEVULINIC-ACID-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/19; endpoint types: /individuals/50/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-021_658874da3e80	gomodel:OHMETHYLBILANESYN-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:OHMETHYLBILANESYN-RXN RO:0002233 gomodel:CHEBI_15377_OHMETHYLBILANESYN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/20; endpoint types: /individuals/14/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-022_f9fdb15cd753	gomodel:OHMETHYLBILANESYN-RXN	RO:0002234	CHEBI:57845	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:OHMETHYLBILANESYN-RXN RO:0002234 gomodel:CHEBI_57845_OHMETHYLBILANESYN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/21; endpoint types: /individuals/14/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-023_62ee09c6bacd	SGD:S000005804	pathwaymech:enables	gomodel:UROGENIIISYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:UROGENIIISYN-RXN RO:0002333 gomodel:YOR278W-MONOMER_UROGENIIISYN-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/22; endpoint types: /individuals/16/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-024_dcdee803b5b6	gomodel:PORPHOBILSYNTH-RXN	BFO:0000050	GO:0033014	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:PORPHOBILSYNTH-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-50/YeastPathways_PWY3O-50."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/23; endpoint types: /individuals/15/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-025_a9cf056b3de3	gomodel:OHMETHYLBILANESYN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:OHMETHYLBILANESYN-RXN BFO:0000066 gomodel:reaction_OHMETHYLBILANESYN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/24; endpoint types: /individuals/14/type; /individuals/47/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-026_2a28e166f253	gomodel:UROGENIIISYN-RXN	BFO:0000050	GO:0033014	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:UROGENIIISYN-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-50/YeastPathways_PWY3O-50."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/25; endpoint types: /individuals/16/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-027_4ad5c334f4e5	gomodel:UROGENIIISYN-RXN	RO:0002233	CHEBI:57845	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:UROGENIIISYN-RXN RO:0002233 gomodel:CHEBI_57845_OHMETHYLBILANESYN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/26; endpoint types: /individuals/16/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-028_7a6d51320d95	gomodel:PORPHOBILSYNTH-RXN	RO:0002233	CHEBI:356416	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:PORPHOBILSYNTH-RXN RO:0002233 gomodel:CHEBI_356416_5-AMINOLEVULINIC-ACID-SYNTHASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/27; endpoint types: /individuals/15/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_edge-029_596d9bef8362	gomodel:PORPHOBILSYNTH-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-50		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_assertion"": ""The model asserts gomodel:PORPHOBILSYNTH-RXN RO:0002234 gomodel:CHEBI_15378_PORPHOBILSYNTH-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-50.json#/facts/28; endpoint types: /individuals/15/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-50"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json"", ""title"": ""SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_location-0e027ab3fc26_24a60ae7f91b	SGD:S000002640	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09950	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:3023841); ECO:0000269 (PubMed:6381051)	"[{""reference_id"": ""UniProtKB:P09950"", ""source_assertion"": ""UniProtKB:P09950 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/233/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P09950"", ""source_assertion"": ""UniProtKB:P09950 has the exact SGD cross-reference SGD:S000002640."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/233/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P09950"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P09950 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_cofactor-3f90339c71e5_9c754bcc26d6	SGD:S000002640	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P09950	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:6381051)	"[{""reference_id"": ""UniProtKB:P09950"", ""source_assertion"": ""UniProtKB:P09950 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/233/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P09950"", ""source_assertion"": ""UniProtKB:P09950 has the exact SGD cross-reference SGD:S000002640."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/233/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P09950"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P09950 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_cofactor-738009d7534e_865d5fbc614f	SGD:S000002364	pathwaymech:has_cofactor	CHEBI:60342	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P28789	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The source describes a covalently attached cofactor moiety. Keep that bound-state qualification; no free cosubstrate consumption is inferred. UniProt evidence: not specified Binds 1 dipyrromethane group covalently. UniProt note evidence: ECO:0000305 (PubMed:1508149)	"[{""reference_id"": ""UniProtKB:P28789"", ""source_assertion"": ""UniProtKB:P28789 annotates CHEBI:60342 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4526/comments/0/cofactors/0; /results/4526/comments/0/note""}, {""reference_id"": ""UniProtKB:P28789"", ""source_assertion"": ""UniProtKB:P28789 has the exact SGD cross-reference SGD:S000002364."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4526/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P28789"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P28789 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-50_cofactor-cbeba9cb670d_d4285f55fdbb	SGD:S000003008	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05373	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10386874) Binds 1 zinc ion per monomer. UniProt note evidence: ECO:0000269 (PubMed:10386874)	"[{""reference_id"": ""UniProtKB:P05373"", ""source_assertion"": ""UniProtKB:P05373 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/104/comments/0/cofactors/0; /results/104/comments/0/note""}, {""reference_id"": ""UniProtKB:P05373"", ""source_assertion"": ""UniProtKB:P05373 has the exact SGD cross-reference SGD:S000003008."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/104/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P05373"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P05373 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-001_3d26677a9b06	gomodel:RXNQT-4301	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17	Native model bridge from ADP-thiazole to thiazole phosphate; the physiological enzyme assignment remains unresolved. THI4 is not assigned to this hydrolysis/decarboxylation step.	"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXNQT-4301 RO:0002234 gomodel:CHEBI_456215_RXNQT-4301."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/0; endpoint types: /individuals/35/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-002_dc7aeca2964d	gomodel:RXNQT-4301	BFO:0000050	GO:0009228	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXNQT-4301 BFO:0000050 gomodel:YeastPathways_PWY3O-17/YeastPathways_PWY3O-17."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/1; endpoint types: /individuals/35/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-003_75a2a944a542	gomodel:PYRIMSYN3-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:PYRIMSYN3-RXN RO:0002234 gomodel:CHEBI_456216_PYRIMSYN3-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/2; endpoint types: /individuals/31/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-004_aa7490e212f1	SGD:S000006179	pathwaymech:enables	gomodel:YeastPathways_PWY3O-17/6a4c244800007660	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007660 RO:0002333 gomodel:YeastPathways_PWY3O-17/6a4c244800007665."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/3; endpoint types: /individuals/103/type; /individuals/107/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-005_d684e2b55999	gomodel:RXNQT-4301	RO:0002234	CHEBI:58296	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17	Native model bridge from ADP-thiazole to thiazole phosphate; the physiological enzyme assignment remains unresolved. THI4 is not assigned to this hydrolysis/decarboxylation step.	"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXNQT-4301 RO:0002234 gomodel:CHEBI_58296_RXNQT-4301."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/4; endpoint types: /individuals/35/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-006_a85a7930b9ed	gomodel:RXNQT-4191	RO:0002233	CHEBI:37575	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXNQT-4191 RO:0002233 gomodel:CHEBI_37575_THI-P-SYN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/5; endpoint types: /individuals/34/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-007_35c9091b2705	gomodel:YeastPathways_PWY3O-17/6a4c244800007677	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007677 RO:0002234 gomodel:YeastPathways_PWY3O-17/6a4c244800007679."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/6; endpoint types: /individuals/119/type; /individuals/121/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-008_b6b61f1d5274	gomodel:RXNQT-4301	RO:0002233	CHEBI:139151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17	Native model bridge from ADP-thiazole to thiazole phosphate; the physiological enzyme assignment remains unresolved. THI4 is not assigned to this hydrolysis/decarboxylation step.	"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXNQT-4301 RO:0002233 gomodel:CHEBI_139151_RXN3O-401."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/7; endpoint types: /individuals/35/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-009_df9cf05b366e	SGD:S000005416	pathwaymech:enables	gomodel:PYRIMSYN3-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:PYRIMSYN3-RXN RO:0002333 gomodel:YeastPathways_PWY3O-17/6690711d00000649."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/8; endpoint types: /individuals/31/type; /individuals/136/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-010_ec2a6b87230a	gomodel:YeastPathways_PWY3O-17/6a4c244800007660	RO:0002233	CHEBI:16892	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007660 RO:0002233 gomodel:CHEBI_16892_RXN3O-9804."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/9; endpoint types: /individuals/103/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-011_3503bb8106bd	gomodel:RXNQT-4191	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXNQT-4191 RO:0002234 gomodel:CHEBI_43474_RXNQT-4191."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/10; endpoint types: /individuals/34/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-012_4e689287d5b0	gomodel:RXN3O-401	BFO:0000050	GO:0009228	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXN3O-401 BFO:0000050 gomodel:YeastPathways_PWY3O-17/YeastPathways_PWY3O-17."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/11; endpoint types: /individuals/32/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-013_e5e53cf8db28	gomodel:THI-P-SYN-RXN	BFO:0000050	GO:0009228	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:THI-P-SYN-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-17/YeastPathways_PWY3O-17."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/12; endpoint types: /individuals/36/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-014_d61996b339d4	gomodel:RXNQT-4191	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXNQT-4191 RO:0002233 gomodel:CHEBI_15377_RXNQT-4191."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/13; endpoint types: /individuals/34/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-015_232440f944da	gomodel:THIAMIN-PYROPHOSPHOKINASE-RXN	BFO:0000050	GO:0009228	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:THIAMIN-PYROPHOSPHOKINASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-17/YeastPathways_PWY3O-17."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/14; endpoint types: /individuals/37/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-017_be4ea345b20e	gomodel:YeastPathways_PWY3O-17/6a4c244800007660	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007660 RO:0002233 gomodel:YeastPathways_PWY3O-17/6a4c244800007661."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/16; endpoint types: /individuals/103/type; /individuals/104/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-018_2ec191cfdeb2	gomodel:RXNQT-4191	RO:0002234	CHEBI:18385	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXNQT-4191 RO:0002234 gomodel:CHEBI_18385_RXNQT-4191."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/17; endpoint types: /individuals/34/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-019_a7a59a107adc	SGD:S000000296	pathwaymech:enables	gomodel:RXNQT-4191	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXNQT-4191 RO:0002333 gomodel:YeastPathways_PWY3O-17/6a4c244800007651."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/18; endpoint types: /individuals/34/type; /individuals/94/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-020_67518c1a05af	gomodel:RXNQT-4301	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17	Native model bridge from ADP-thiazole to thiazole phosphate; the physiological enzyme assignment remains unresolved. THI4 is not assigned to this hydrolysis/decarboxylation step.	"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXNQT-4301 RO:0002234 gomodel:CHEBI_16526_RXNQT-4301."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/19; endpoint types: /individuals/35/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-021_1206e183a2f8	gomodel:RXN3O-9804	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9804 BFO:0000066 gomodel:reaction_RXN3O-9804_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/20; endpoint types: /individuals/33/type; /individuals/86/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-022_230447a6a1cc	gomodel:OHMETPYRKIN-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-17/6a4c244800007677	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:OHMETPYRKIN-RXN RO:0002413 gomodel:YeastPathways_PWY3O-17/6a4c244800007677."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/21; endpoint types: /individuals/30/type; /individuals/119/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-023_9465e22f1e46	gomodel:PYRIMSYN3-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:PYRIMSYN3-RXN RO:0002233 gomodel:CHEBI_30616_PYRIMSYN3-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/22; endpoint types: /individuals/31/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-024_8bb39b3e5412	gomodel:THIAMIN-PYROPHOSPHOKINASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:THIAMIN-PYROPHOSPHOKINASE-RXN BFO:0000066 gomodel:reaction_THIAMIN-PYROPHOSPHOKINASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/23; endpoint types: /individuals/37/type; /individuals/90/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-025_2c53fade3f99	gomodel:THI-P-SYN-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:THI-P-SYN-RXN RO:0002234 gomodel:CHEBI_29888_THI-P-SYN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/24; endpoint types: /individuals/36/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-027_493a364ea710	gomodel:OHMETPYRKIN-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:OHMETPYRKIN-RXN RO:0002234 gomodel:CHEBI_456216_OHMETPYRKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/26; endpoint types: /individuals/30/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-028_3c2e12aab7ee	gomodel:THI-P-SYN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:THI-P-SYN-RXN BFO:0000066 gomodel:reaction_THI-P-SYN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/27; endpoint types: /individuals/36/type; /individuals/89/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-029_f85b05b83ce6	gomodel:THIAMIN-PYROPHOSPHOKINASE-RXN	RO:0002234	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:THIAMIN-PYROPHOSPHOKINASE-RXN RO:0002234 gomodel:CHEBI_58937_THIAMIN-PYROPHOSPHOKINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/28; endpoint types: /individuals/37/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-030_430ed5829be5	gomodel:THI-P-SYN-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:THI-P-SYN-RXN RO:0002233 gomodel:CHEBI_15378_THI-P-SYN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/29; endpoint types: /individuals/36/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-031_29b80ebed7ff	gomodel:YeastPathways_PWY3O-17/6a4c244800007660	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007660 RO:0002234 gomodel:YeastPathways_PWY3O-17/6a4c244800007662."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/30; endpoint types: /individuals/103/type; /individuals/105/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-032_38560111c2fd	gomodel:PYRIMSYN3-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:PYRIMSYN3-RXN BFO:0000066 gomodel:reaction_PYRIMSYN3-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/31; endpoint types: /individuals/31/type; /individuals/84/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-033_739845c3f774	gomodel:THIAMIN-PYROPHOSPHOKINASE-RXN	RO:0002233	CHEBI:18385	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:THIAMIN-PYROPHOSPHOKINASE-RXN RO:0002233 gomodel:CHEBI_18385_RXNQT-4191."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/32; endpoint types: /individuals/37/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-034_233f11466e15	gomodel:YeastPathways_PWY3O-17/6a4c244800007660	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007660 RO:0002234 gomodel:YeastPathways_PWY3O-17/6a4c244800007663."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/33; endpoint types: /individuals/103/type; /individuals/106/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-035_d1c23c4ef818	SGD:S000006179	pathwaymech:enables	gomodel:YeastPathways_PWY3O-17/6a4c244800007677	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007677 RO:0002333 gomodel:YeastPathways_PWY3O-17/6a4c244800007680."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/34; endpoint types: /individuals/119/type; /individuals/122/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-037_2ebccce55107	gomodel:THI-P-SYN-RXN	RO:0002233	CHEBI:58296	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:THI-P-SYN-RXN RO:0002233 gomodel:CHEBI_58296_RXNQT-4301."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/36; endpoint types: /individuals/36/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-039_d5286b19c3b7	gomodel:OHMETPYRKIN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:OHMETPYRKIN-RXN RO:0002233 gomodel:CHEBI_30616_OHMETPYRKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/38; endpoint types: /individuals/30/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-040_64b2fb189e42	gomodel:YeastPathways_PWY3O-17/6a4c244800007677	RO:0002234	CHEBI:57841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007677 RO:0002234 gomodel:CHEBI_57841_PYRIMSYN3-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/39; endpoint types: /individuals/119/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-041_e4dc89f2f538	gomodel:YeastPathways_PWY3O-17/6a4c244800007677	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007677 RO:0002233 gomodel:YeastPathways_PWY3O-17/6a4c244800007678."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/40; endpoint types: /individuals/119/type; /individuals/120/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-042_9b37c807933d	SGD:S000005669	pathwaymech:enables	gomodel:THIAMIN-PYROPHOSPHOKINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:THIAMIN-PYROPHOSPHOKINASE-RXN RO:0002333 gomodel:YeastPathways_PWY3O-17/6690711d00000657."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/41; endpoint types: /individuals/37/type; /individuals/142/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-043_e6037ed1eb5a	gomodel:THIAMIN-PYROPHOSPHOKINASE-RXN	RO:0002234	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:THIAMIN-PYROPHOSPHOKINASE-RXN RO:0002234 gomodel:CHEBI_456215_THIAMIN-PYROPHOSPHOKINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/42; endpoint types: /individuals/37/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-044_8c1c7102877e	gomodel:RXN3O-9804	BFO:0000050	GO:0009228	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9804 BFO:0000050 gomodel:YeastPathways_PWY3O-17/YeastPathways_PWY3O-17."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/43; endpoint types: /individuals/33/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-045_694a5f676779	gomodel:RXN3O-401	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXN3O-401 BFO:0000066 gomodel:reaction_RXN3O-401_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/44; endpoint types: /individuals/32/type; /individuals/85/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-046_06b1c386e417	gomodel:RXN3O-401	RO:0002413	gomodel:RXNQT-4301	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXN3O-401 RO:0002413 gomodel:RXNQT-4301."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/45; endpoint types: /individuals/32/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-047_207fc51b0914	gomodel:OHMETPYRKIN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:OHMETPYRKIN-RXN BFO:0000066 gomodel:reaction_OHMETPYRKIN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/46; endpoint types: /individuals/30/type; /individuals/83/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-048_8e404facd00e	gomodel:RXNQT-4191	BFO:0000050	GO:0009228	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXNQT-4191 BFO:0000050 gomodel:YeastPathways_PWY3O-17/YeastPathways_PWY3O-17."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/47; endpoint types: /individuals/34/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-049_dc68072e4f13	gomodel:YeastPathways_PWY3O-17/6a4c244800007677	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007677 BFO:0000066 gomodel:YeastPathways_PWY3O-17/6a4c244800007682."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/48; endpoint types: /individuals/119/type; /individuals/123/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-050_02262ff2eb4b	gomodel:PYRIMSYN3-RXN	RO:0002233	CHEBI:58354	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:PYRIMSYN3-RXN RO:0002233 gomodel:CHEBI_58354_OHMETPYRKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/49; endpoint types: /individuals/31/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-051_c4b2853f5cb2	gomodel:RXNQT-4301	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXNQT-4301 BFO:0000066 gomodel:reaction_RXNQT-4301_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/50; endpoint types: /individuals/35/type; /individuals/88/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-052_ffbfd51e96bb	gomodel:YeastPathways_PWY3O-17/6a4c244800007660	RO:0002234	CHEBI:58354	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007660 RO:0002234 gomodel:CHEBI_58354_OHMETPYRKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/51; endpoint types: /individuals/103/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-053_c7d1fb40a1d5	gomodel:RXNQT-4301	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17	Native model bridge from ADP-thiazole to thiazole phosphate; the physiological enzyme assignment remains unresolved. THI4 is not assigned to this hydrolysis/decarboxylation step.	"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXNQT-4301 RO:0002234 gomodel:CHEBI_15378_RXNQT-4301."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/52; endpoint types: /individuals/35/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-054_6e012b90b480	gomodel:OHMETPYRKIN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:OHMETPYRKIN-RXN RO:0002234 gomodel:CHEBI_15378_OHMETPYRKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/53; endpoint types: /individuals/30/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-055_449529ef5f66	gomodel:RXNQT-4301	RO:0002413	gomodel:THI-P-SYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXNQT-4301 RO:0002413 gomodel:THI-P-SYN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/54; endpoint types: /individuals/35/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-057_e5413ebb2436	gomodel:YeastPathways_PWY3O-17/6a4c244800007677	RO:0002413	gomodel:THI-P-SYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007677 RO:0002413 gomodel:THI-P-SYN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/56; endpoint types: /individuals/119/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-058_bc8a9dcb6b49	gomodel:YeastPathways_PWY3O-17/6a4c244800007660	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007660 BFO:0000066 gomodel:YeastPathways_PWY3O-17/6a4c244800007666."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/57; endpoint types: /individuals/103/type; /individuals/108/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-059_ee45f7fbe75c	gomodel:THIAMIN-PYROPHOSPHOKINASE-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:THIAMIN-PYROPHOSPHOKINASE-RXN RO:0002233 gomodel:CHEBI_30616_THIAMIN-PYROPHOSPHOKINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/58; endpoint types: /individuals/37/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-060_9983e22f9ec5	gomodel:THIAMIN-PYROPHOSPHOKINASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:THIAMIN-PYROPHOSPHOKINASE-RXN RO:0002234 gomodel:CHEBI_15378_THIAMIN-PYROPHOSPHOKINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/59; endpoint types: /individuals/37/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-062_6ee2816d0fec	gomodel:RXNQT-4191	RO:0002413	gomodel:THIAMIN-PYROPHOSPHOKINASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXNQT-4191 RO:0002413 gomodel:THIAMIN-PYROPHOSPHOKINASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/61; endpoint types: /individuals/34/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-063_79d31c347802	gomodel:YeastPathways_PWY3O-17/6a4c244800007660	BFO:0000050	GO:0009228	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007660 BFO:0000050 gomodel:YeastPathways_PWY3O-17/YeastPathways_PWY3O-17."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/62; endpoint types: /individuals/103/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-064_37924f9eeb56	gomodel:OHMETPYRKIN-RXN	RO:0002234	CHEBI:58354	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:OHMETPYRKIN-RXN RO:0002234 gomodel:CHEBI_58354_OHMETPYRKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/63; endpoint types: /individuals/30/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-065_631cddfe6546	gomodel:PYRIMSYN3-RXN	RO:0002413	gomodel:THI-P-SYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:PYRIMSYN3-RXN RO:0002413 gomodel:THI-P-SYN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/64; endpoint types: /individuals/31/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-066_6f1bf22cb9ef	gomodel:OHMETPYRKIN-RXN	BFO:0000050	GO:0009228	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:OHMETPYRKIN-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-17/YeastPathways_PWY3O-17."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/65; endpoint types: /individuals/30/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-067_24ff004d8e11	SGD:S000006135	pathwaymech:enables	gomodel:THI-P-SYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:THI-P-SYN-RXN RO:0002333 gomodel:YeastPathways_PWY3O-17/6690711d00000655."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/66; endpoint types: /individuals/36/type; /individuals/140/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-068_591f6b6c71f6	gomodel:PYRIMSYN3-RXN	RO:0002234	CHEBI:57841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:PYRIMSYN3-RXN RO:0002234 gomodel:CHEBI_57841_PYRIMSYN3-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/67; endpoint types: /individuals/31/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-069_05c816b4f33d	gomodel:YeastPathways_PWY3O-17/6a4c244800007677	BFO:0000050	GO:0009228	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007677 BFO:0000050 gomodel:YeastPathways_PWY3O-17/YeastPathways_PWY3O-17."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/68; endpoint types: /individuals/119/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-071_10e7bc3fbeca	gomodel:THI-P-SYN-RXN	RO:0002234	CHEBI:37575	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:THI-P-SYN-RXN RO:0002234 gomodel:CHEBI_37575_THI-P-SYN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/70; endpoint types: /individuals/36/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-073_141d35ddade5	gomodel:RXNQT-4301	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17	Native model bridge from ADP-thiazole to thiazole phosphate; the physiological enzyme assignment remains unresolved. THI4 is not assigned to this hydrolysis/decarboxylation step.	"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXNQT-4301 RO:0002233 gomodel:CHEBI_15377_RXNQT-4301."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/72; endpoint types: /individuals/35/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-074_359084327a17	gomodel:OHMETPYRKIN-RXN	RO:0002413	gomodel:PYRIMSYN3-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:OHMETPYRKIN-RXN RO:0002413 gomodel:PYRIMSYN3-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/73; endpoint types: /individuals/30/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-075_32594a90c7f2	SGD:S000005416	pathwaymech:enables	gomodel:OHMETPYRKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:OHMETPYRKIN-RXN RO:0002333 gomodel:YeastPathways_PWY3O-17/6690711d00000645."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/74; endpoint types: /individuals/30/type; /individuals/134/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-076_4c3bafdb0f33	gomodel:YeastPathways_PWY3O-17/6a4c244800007660	RO:0002413	gomodel:YeastPathways_PWY3O-17/6a4c244800007677	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007660 RO:0002413 gomodel:YeastPathways_PWY3O-17/6a4c244800007677."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/75; endpoint types: /individuals/103/type; /individuals/119/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-079_c0577ee1adb0	gomodel:THI-P-SYN-RXN	RO:0002233	CHEBI:57841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:THI-P-SYN-RXN RO:0002233 gomodel:CHEBI_57841_PYRIMSYN3-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/78; endpoint types: /individuals/36/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-080_8d08b0d63a32	gomodel:YeastPathways_PWY3O-17/6a4c244800007677	RO:0002233	CHEBI:58354	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007677 RO:0002233 gomodel:CHEBI_58354_OHMETPYRKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/79; endpoint types: /individuals/119/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-081_8d3d6440b22a	gomodel:OHMETPYRKIN-RXN	RO:0002233	CHEBI:16892	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:OHMETPYRKIN-RXN RO:0002233 gomodel:CHEBI_16892_RXN3O-9804."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/80; endpoint types: /individuals/30/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-082_5a5a27c291d8	SGD:S000003376	pathwaymech:enables	gomodel:RXN3O-401	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXN3O-401 RO:0002333 gomodel:YeastPathways_PWY3O-17/6690711d00000653."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/81; endpoint types: /individuals/32/type; /individuals/138/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-083_02079680d229	gomodel:PYRIMSYN3-RXN	BFO:0000050	GO:0009228	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:PYRIMSYN3-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-17/YeastPathways_PWY3O-17."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/82; endpoint types: /individuals/31/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-084_e1bbaa0dc89c	gomodel:RXNQT-4191	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXNQT-4191 BFO:0000066 gomodel:reaction_RXNQT-4191_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/83; endpoint types: /individuals/34/type; /individuals/87/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-085_66601914ffaf	gomodel:YeastPathways_PWY3O-17/6a4c244800007660	RO:0002413	gomodel:PYRIMSYN3-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007660 RO:0002413 gomodel:PYRIMSYN3-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/84; endpoint types: /individuals/103/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-086_a5aaf64da3ad	SGD:S000002403	pathwaymech:enables	gomodel:RXN3O-9804	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q07748|gomodel:YeastPathways_PWY3O-17	Single-turnover THI13 chemistry inferred by similarity to THI5 (ECO:0000250, UniProtKB:P43534). Histidine and PLP-lysine are protein-bound residues, not free histidine substrates. HMP-phosphate is the product. The inherited exact iron redox, water/proton balance, 3-oxopropanoate and residue-product assertions are quarantined: PMID:35675507 reports Fe(II)/oxygen dependence and different PLP-derived products for Candida albicans THI5, and a histidine-derived alpha-ketoacid for both Candida THI5 and S. cerevisiae THI5. These homolog experiments are not direct evidence for S. cerevisiae THI13; no replacement oxygen or product edges, or complete net stoichiometry, are inferred. Omitted products and balancing species remain unresolved, rather than asserted absent.	"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9804 RO:0002333 gomodel:MONOMER3O-9145_RXN3O-9804_controller."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/85; endpoint types: /individuals/33/type; /individuals/29/type""}, {""reference_id"": ""UniProtKB:Q07748"", ""source_assertion"": ""THI13 uses its active-site histidine and protein-bound PLP to form HMP-phosphate in a single turnover, generating inactive enzyme; this annotation is inferred by similarity to THI5."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/Q07748.json [sha256:3b3a42882440ce399581bed512ee732900b8883a786945a0ffa216a8b33a7755] #/comments/0/texts/0""}]"	"[{""id"": ""UniProtKB:Q07748"", ""source_sha256"": ""3b3a42882440ce399581bed512ee732900b8883a786945a0ffa216a8b33a7755"", ""source_version"": ""2026_03"", ""title"": ""Reviewed UniProt Q07748: bounded catalytic-function review"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q07748.json""}, {""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_edge-087_09902fc7b4b7	gomodel:THI-P-SYN-RXN	RO:0002413	gomodel:RXNQT-4191	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-17		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:THI-P-SYN-RXN RO:0002413 gomodel:RXNQT-4191."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/86; endpoint types: /individuals/36/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_location-ac63fef5a650_9ad4dfb07f3f	SGD:S000003376	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32318	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:15544818); ECO:0000269 (PubMed:16850348) Source qualification: Excluded from the vacuole	"[{""reference_id"": ""UniProtKB:P32318"", ""source_assertion"": ""UniProtKB:P32318 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/861/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32318"", ""source_assertion"": ""UniProtKB:P32318 has the exact SGD cross-reference SGD:S000003376."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/861/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32318"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32318 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_location-e9cd58093a12_9542c2ade427	SGD:S000003376	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32318	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16850348) Source qualification: Excluded from the vacuole	"[{""reference_id"": ""UniProtKB:P32318"", ""source_assertion"": ""UniProtKB:P32318 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/861/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32318"", ""source_assertion"": ""UniProtKB:P32318 has the exact SGD cross-reference SGD:S000003376."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/861/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32318"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32318 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_function-61fdd10aa59d_ca47012ad838	gomodel:RXN3O-9804	RO:0002233	CHEBI:143915	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q07748	Single-turnover THI13 chemistry inferred by similarity to THI5 (ECO:0000250, UniProtKB:P43534). Histidine and PLP-lysine are protein-bound residues, not free histidine substrates. HMP-phosphate is the product. The inherited exact iron redox, water/proton balance, 3-oxopropanoate and residue-product assertions are quarantined: PMID:35675507 reports Fe(II)/oxygen dependence and different PLP-derived products for Candida albicans THI5, and a histidine-derived alpha-ketoacid for both Candida THI5 and S. cerevisiae THI5. These homolog experiments are not direct evidence for S. cerevisiae THI13; no replacement oxygen or product edges, or complete net stoichiometry, are inferred. Omitted products and balancing species remain unresolved, rather than asserted absent.	"[{""reference_id"": ""UniProtKB:Q07748"", ""source_assertion"": ""The THI13 annotation, inferred by similarity to THI5, uses protein-bound PLP-lysine and histidine residues and forms HMP-phosphate. This bounded projection retains those core endpoints of the source equation, without asserting its exact net stoichiometry or residue and small-molecule products."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/Q07748.json [sha256:3b3a42882440ce399581bed512ee732900b8883a786945a0ffa216a8b33a7755] #/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q07748"", ""source_sha256"": ""3b3a42882440ce399581bed512ee732900b8883a786945a0ffa216a8b33a7755"", ""source_version"": ""2026_03"", ""title"": ""Reviewed UniProt Q07748: bounded catalytic-function review"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q07748.json""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_function-d06c8b080abf_95d3249dbdf8	gomodel:RXN3O-9804	RO:0002233	CHEBI:29979	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q07748	Single-turnover THI13 chemistry inferred by similarity to THI5 (ECO:0000250, UniProtKB:P43534). Histidine and PLP-lysine are protein-bound residues, not free histidine substrates. HMP-phosphate is the product. The inherited exact iron redox, water/proton balance, 3-oxopropanoate and residue-product assertions are quarantined: PMID:35675507 reports Fe(II)/oxygen dependence and different PLP-derived products for Candida albicans THI5, and a histidine-derived alpha-ketoacid for both Candida THI5 and S. cerevisiae THI5. These homolog experiments are not direct evidence for S. cerevisiae THI13; no replacement oxygen or product edges, or complete net stoichiometry, are inferred. Omitted products and balancing species remain unresolved, rather than asserted absent.	"[{""reference_id"": ""UniProtKB:Q07748"", ""source_assertion"": ""The THI13 annotation, inferred by similarity to THI5, uses protein-bound PLP-lysine and histidine residues and forms HMP-phosphate. This bounded projection retains those core endpoints of the source equation, without asserting its exact net stoichiometry or residue and small-molecule products."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/Q07748.json [sha256:3b3a42882440ce399581bed512ee732900b8883a786945a0ffa216a8b33a7755] #/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q07748"", ""source_sha256"": ""3b3a42882440ce399581bed512ee732900b8883a786945a0ffa216a8b33a7755"", ""source_version"": ""2026_03"", ""title"": ""Reviewed UniProt Q07748: bounded catalytic-function review"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q07748.json""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_function-65069bb6ff1e_81ab84abb08a	gomodel:RXN3O-9804	RO:0002234	CHEBI:58354	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q07748	Single-turnover THI13 chemistry inferred by similarity to THI5 (ECO:0000250, UniProtKB:P43534). Histidine and PLP-lysine are protein-bound residues, not free histidine substrates. HMP-phosphate is the product. The inherited exact iron redox, water/proton balance, 3-oxopropanoate and residue-product assertions are quarantined: PMID:35675507 reports Fe(II)/oxygen dependence and different PLP-derived products for Candida albicans THI5, and a histidine-derived alpha-ketoacid for both Candida THI5 and S. cerevisiae THI5. These homolog experiments are not direct evidence for S. cerevisiae THI13; no replacement oxygen or product edges, or complete net stoichiometry, are inferred. Omitted products and balancing species remain unresolved, rather than asserted absent.	"[{""reference_id"": ""UniProtKB:Q07748"", ""source_assertion"": ""The THI13 annotation, inferred by similarity to THI5, uses protein-bound PLP-lysine and histidine residues and forms HMP-phosphate. This bounded projection retains those core endpoints of the source equation, without asserting its exact net stoichiometry or residue and small-molecule products."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/Q07748.json [sha256:3b3a42882440ce399581bed512ee732900b8883a786945a0ffa216a8b33a7755] #/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:Q07748"", ""source_sha256"": ""3b3a42882440ce399581bed512ee732900b8883a786945a0ffa216a8b33a7755"", ""source_version"": ""2026_03"", ""title"": ""Reviewed UniProt Q07748: bounded catalytic-function review"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q07748.json""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_function-c890fae71f8d_e23041224826	gomodel:RXN3O-9804	RO:0002413	gomodel:PYRIMSYN3-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q07748|gomodel:YeastPathways_PWY3O-17	Single-turnover THI13 chemistry inferred by similarity to THI5 (ECO:0000250, UniProtKB:P43534). Histidine and PLP-lysine are protein-bound residues, not free histidine substrates. HMP-phosphate is the product. The inherited exact iron redox, water/proton balance, 3-oxopropanoate and residue-product assertions are quarantined: PMID:35675507 reports Fe(II)/oxygen dependence and different PLP-derived products for Candida albicans THI5, and a histidine-derived alpha-ketoacid for both Candida THI5 and S. cerevisiae THI5. These homolog experiments are not direct evidence for S. cerevisiae THI13; no replacement oxygen or product edges, or complete net stoichiometry, are inferred. Omitted products and balancing species remain unresolved, rather than asserted absent.	"[{""reference_id"": ""UniProtKB:Q07748"", ""source_assertion"": ""THI13 has HMP-phosphate as a product; it supplies the substrate of the source model's phosphomethylpyrimidine kinase activities."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/Q07748.json [sha256:3b3a42882440ce399581bed512ee732900b8883a786945a0ffa216a8b33a7755] #/comments/1/reaction""}, {""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:PYRIMSYN3-RXN RO:0002233 gomodel:CHEBI_58354_OHMETPYRKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/49; endpoint types: /individuals/31/type; /individuals/26/type""}]"	"[{""id"": ""UniProtKB:Q07748"", ""source_sha256"": ""3b3a42882440ce399581bed512ee732900b8883a786945a0ffa216a8b33a7755"", ""source_version"": ""2026_03"", ""title"": ""Reviewed UniProt Q07748: bounded catalytic-function review"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q07748.json""}, {""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_function-22e6814dd574_84abfed118b4	gomodel:RXN3O-9804	RO:0002413	gomodel:YeastPathways_PWY3O-17/6a4c244800007677	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q07748|gomodel:YeastPathways_PWY3O-17	Single-turnover THI13 chemistry inferred by similarity to THI5 (ECO:0000250, UniProtKB:P43534). Histidine and PLP-lysine are protein-bound residues, not free histidine substrates. HMP-phosphate is the product. The inherited exact iron redox, water/proton balance, 3-oxopropanoate and residue-product assertions are quarantined: PMID:35675507 reports Fe(II)/oxygen dependence and different PLP-derived products for Candida albicans THI5, and a histidine-derived alpha-ketoacid for both Candida THI5 and S. cerevisiae THI5. These homolog experiments are not direct evidence for S. cerevisiae THI13; no replacement oxygen or product edges, or complete net stoichiometry, are inferred. Omitted products and balancing species remain unresolved, rather than asserted absent.	"[{""reference_id"": ""UniProtKB:Q07748"", ""source_assertion"": ""THI13 has HMP-phosphate as a product; it supplies the substrate of the source model's phosphomethylpyrimidine kinase activities."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/Q07748.json [sha256:3b3a42882440ce399581bed512ee732900b8883a786945a0ffa216a8b33a7755] #/comments/1/reaction""}, {""reference_id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-17/6a4c244800007677 RO:0002233 gomodel:CHEBI_58354_OHMETPYRKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-17.json#/facts/79; endpoint types: /individuals/119/type; /individuals/26/type""}]"	"[{""id"": ""UniProtKB:Q07748"", ""source_sha256"": ""3b3a42882440ce399581bed512ee732900b8883a786945a0ffa216a8b33a7755"", ""source_version"": ""2026_03"", ""title"": ""Reviewed UniProt Q07748: bounded catalytic-function review"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q07748.json""}, {""id"": ""gomodel:YeastPathways_PWY3O-17"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PWY3O-17.json"", ""title"": ""SGD GO-CAM thiamine biosynthesis pathway PWY3O-17"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_function-08ab80fa07b2_4216916145cc	gomodel:RXN3O-401	RO:0002233	CHEBI:29950	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32318	THI4 forms ADP-thiazole using its own cysteine residue as sulfur donor, leaving a dehydroalanine residue after one turnover. The reviewed equation produces three waters and two H+; it does not identify THI4 as the enzyme for downstream ADP-thiazole hydrolysis.	"[{""reference_id"": ""UniProtKB:P32318"", ""source_assertion"": ""[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)"", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/P32318.json [sha256:c07f0cf9365410e43a34cc0f50d55b265f76a045e0dddb5821c6bb3c9120ec60] #/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P32318"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32318 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_function-f38c0470cb66_8ee7fbc5b1bd	gomodel:RXN3O-401	RO:0002233	CHEBI:57305	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32318	THI4 forms ADP-thiazole using its own cysteine residue as sulfur donor, leaving a dehydroalanine residue after one turnover. The reviewed equation produces three waters and two H+; it does not identify THI4 as the enzyme for downstream ADP-thiazole hydrolysis.	"[{""reference_id"": ""UniProtKB:P32318"", ""source_assertion"": ""[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)"", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/P32318.json [sha256:c07f0cf9365410e43a34cc0f50d55b265f76a045e0dddb5821c6bb3c9120ec60] #/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P32318"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32318 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_function-2019d705d002_1649e5b67704	gomodel:RXN3O-401	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32318	THI4 forms ADP-thiazole using its own cysteine residue as sulfur donor, leaving a dehydroalanine residue after one turnover. The reviewed equation produces three waters and two H+; it does not identify THI4 as the enzyme for downstream ADP-thiazole hydrolysis.	"[{""reference_id"": ""UniProtKB:P32318"", ""source_assertion"": ""[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)"", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/P32318.json [sha256:c07f0cf9365410e43a34cc0f50d55b265f76a045e0dddb5821c6bb3c9120ec60] #/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P32318"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32318 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_function-d5550718ad32_c25b43b3f140	gomodel:RXN3O-401	RO:0002234	CHEBI:90873	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32318	THI4 forms ADP-thiazole using its own cysteine residue as sulfur donor, leaving a dehydroalanine residue after one turnover. The reviewed equation produces three waters and two H+; it does not identify THI4 as the enzyme for downstream ADP-thiazole hydrolysis.	"[{""reference_id"": ""UniProtKB:P32318"", ""source_assertion"": ""[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)"", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/P32318.json [sha256:c07f0cf9365410e43a34cc0f50d55b265f76a045e0dddb5821c6bb3c9120ec60] #/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P32318"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32318 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_function-aafc4502e0ce_03eaa8fc349c	gomodel:RXN3O-401	RO:0002234	CHEBI:139151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32318	THI4 forms ADP-thiazole using its own cysteine residue as sulfur donor, leaving a dehydroalanine residue after one turnover. The reviewed equation produces three waters and two H+; it does not identify THI4 as the enzyme for downstream ADP-thiazole hydrolysis.	"[{""reference_id"": ""UniProtKB:P32318"", ""source_assertion"": ""[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)"", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/P32318.json [sha256:c07f0cf9365410e43a34cc0f50d55b265f76a045e0dddb5821c6bb3c9120ec60] #/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P32318"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32318 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_function-c2b38483a732_61417b340cd9	gomodel:RXN3O-401	RO:0002234	CHEBI:17154	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32318	THI4 forms ADP-thiazole using its own cysteine residue as sulfur donor, leaving a dehydroalanine residue after one turnover. The reviewed equation produces three waters and two H+; it does not identify THI4 as the enzyme for downstream ADP-thiazole hydrolysis.	"[{""reference_id"": ""UniProtKB:P32318"", ""source_assertion"": ""[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)"", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/P32318.json [sha256:c07f0cf9365410e43a34cc0f50d55b265f76a045e0dddb5821c6bb3c9120ec60] #/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P32318"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32318 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_function-4a648ecaee6c_bbf3ff730492	gomodel:RXN3O-401	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32318	THI4 forms ADP-thiazole using its own cysteine residue as sulfur donor, leaving a dehydroalanine residue after one turnover. The reviewed equation produces three waters and two H+; it does not identify THI4 as the enzyme for downstream ADP-thiazole hydrolysis.	"[{""reference_id"": ""UniProtKB:P32318"", ""source_assertion"": ""[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)"", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/P32318.json [sha256:c07f0cf9365410e43a34cc0f50d55b265f76a045e0dddb5821c6bb3c9120ec60] #/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P32318"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32318 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_function-f57cd61a0aa3_91976b4c86f2	gomodel:RXN3O-401	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32318	THI4 forms ADP-thiazole using its own cysteine residue as sulfur donor, leaving a dehydroalanine residue after one turnover. The reviewed equation produces three waters and two H+; it does not identify THI4 as the enzyme for downstream ADP-thiazole hydrolysis.	"[{""reference_id"": ""UniProtKB:P32318"", ""source_assertion"": ""[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)"", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/P32318.json [sha256:c07f0cf9365410e43a34cc0f50d55b265f76a045e0dddb5821c6bb3c9120ec60] #/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P32318"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32318 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_cofactor-7650a75576a3_765ddbf0a505	SGD:S000003376	pathwaymech:has_cofactor	CHEBI:24875	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32318	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:22031445) Binds 1 Fe cation per subunit. UniProt note evidence: ECO:0000269 (PubMed:22031445)	"[{""reference_id"": ""UniProtKB:P32318"", ""source_assertion"": ""UniProtKB:P32318 annotates CHEBI:24875 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/861/comments/0/cofactors/0; /results/861/comments/0/note""}, {""reference_id"": ""UniProtKB:P32318"", ""source_assertion"": ""UniProtKB:P32318 has the exact SGD cross-reference SGD:S000003376."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/861/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32318"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32318 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_cofactor-01d1e7e950e7_4e075d1d5ab7	SGD:S000006135	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41835	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) ion per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P41835"", ""source_assertion"": ""UniProtKB:P41835 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1822/comments/0/cofactors/0; /results/1822/comments/0/note""}, {""reference_id"": ""UniProtKB:P41835"", ""source_assertion"": ""UniProtKB:P41835 has the exact SGD cross-reference SGD:S000006135."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1822/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P41835"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P41835 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-17_cofactor-0a39df6c6817_5b28f105db28	SGD:S000002403	pathwaymech:has_cofactor	CHEBI:24875	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q07748	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P43534)	"[{""reference_id"": ""UniProtKB:Q07748"", ""source_assertion"": ""UniProtKB:Q07748 annotates CHEBI:24875 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4991/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:Q07748"", ""source_assertion"": ""UniProtKB:Q07748 has the exact SGD cross-reference SGD:S000002403."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4991/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q07748"", ""source_sha256"": ""3b3a42882440ce399581bed512ee732900b8883a786945a0ffa216a8b33a7755"", ""source_version"": ""2026_03"", ""title"": ""Reviewed UniProt Q07748: bounded catalytic-function review"", ""url"": ""https://rest.uniprot.org/uniprotkb/Q07748.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-001_34c255627be6	RHEA-COMP:12158	pathwaymech:consumes	RHEA:17458	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17457	Coefficient 1 in the selected biosynthetic direction. Whole protein carrier state is retained; the reactive ChEBI residue is not substituted for the protein.	"[{""reference_id"": ""RHEA:17457"", ""source_assertion"": ""RHEA:17458 substrates contain RHEA-COMP:12158 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17458 rh:substrates; http://rdf.rhea-db.org/17457_L rh:contains1 http://rdf.rhea-db.org/Participant_17457_compound_12158; rh:compound http://rdf.rhea-db.org/Compound_12158""}]"	"[{""id"": ""RHEA:17457"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 17457"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-002_124dec880094	CHEBI:35235	pathwaymech:consumes	RHEA:17458	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17457	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:17457"", ""source_assertion"": ""RHEA:17458 substrates contain CHEBI:35235 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17458 rh:substrates; http://rdf.rhea-db.org/17457_L rh:contains1 http://rdf.rhea-db.org/Participant_17457_compound_2467; rh:compound http://rdf.rhea-db.org/Compound_2467""}]"	"[{""id"": ""RHEA:17457"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 17457"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-003_a3162a9971df	RHEA:17458	pathwaymech:produces	RHEA-COMP:12157	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17457	Coefficient 1 in the selected biosynthetic direction. Whole protein carrier state is retained; the reactive ChEBI residue is not substituted for the protein.	"[{""reference_id"": ""RHEA:17457"", ""source_assertion"": ""RHEA:17458 products contain RHEA-COMP:12157 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17458 rh:products; http://rdf.rhea-db.org/17457_R rh:contains1 http://rdf.rhea-db.org/Participant_17457_compound_12157; rh:compound http://rdf.rhea-db.org/Compound_12157""}]"	"[{""id"": ""RHEA:17457"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 17457"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-004_ba2f06caf765	RHEA:17458	pathwaymech:produces	CHEBI:57972	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:17457	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:17457"", ""source_assertion"": ""RHEA:17458 products contain CHEBI:57972 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/17458 rh:products; http://rdf.rhea-db.org/17457_R rh:contains1 http://rdf.rhea-db.org/Participant_17457_compound_3361; rh:compound http://rdf.rhea-db.org/Compound_3361""}]"	"[{""id"": ""RHEA:17457"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 17457"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-005_6466f32b3a32	RHEA-COMP:12909	pathwaymech:consumes	RHEA:43345	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43344	Coefficient 1 in the selected biosynthetic direction. Whole protein carrier state is retained; the reactive ChEBI residue is not substituted for the protein.	"[{""reference_id"": ""RHEA:43344"", ""source_assertion"": ""RHEA:43345 substrates contain RHEA-COMP:12909 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43345 rh:substrates; http://rdf.rhea-db.org/43344_L rh:contains1 http://rdf.rhea-db.org/Participant_43344_compound_12909; rh:compound http://rdf.rhea-db.org/Compound_12909""}]"	"[{""id"": ""RHEA:43344"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 43344"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-006_968d93a7417d	CHEBI:30616	pathwaymech:consumes	RHEA:43345	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43344	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:43344"", ""source_assertion"": ""RHEA:43345 substrates contain CHEBI:30616 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43345 rh:substrates; http://rdf.rhea-db.org/43344_L rh:contains1 http://rdf.rhea-db.org/Participant_43344_compound_6372; rh:compound http://rdf.rhea-db.org/Compound_6372""}]"	"[{""id"": ""RHEA:43344"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 43344"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-007_14d06b4fb850	CHEBI:15378	pathwaymech:consumes	RHEA:43345	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43344	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:43344"", ""source_assertion"": ""RHEA:43345 substrates contain CHEBI:15378 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43345 rh:substrates; http://rdf.rhea-db.org/43344_L rh:contains1 http://rdf.rhea-db.org/Participant_43344_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249""}]"	"[{""id"": ""RHEA:43344"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 43344"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-008_c507fd00ec1b	RHEA:43345	pathwaymech:produces	RHEA-COMP:12910	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43344	Coefficient 1 in the selected biosynthetic direction. Whole protein carrier state is retained; the reactive ChEBI residue is not substituted for the protein.	"[{""reference_id"": ""RHEA:43344"", ""source_assertion"": ""RHEA:43345 products contain RHEA-COMP:12910 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43345 rh:products; http://rdf.rhea-db.org/43344_R rh:contains1 http://rdf.rhea-db.org/Participant_43344_compound_12910; rh:compound http://rdf.rhea-db.org/Compound_12910""}]"	"[{""id"": ""RHEA:43344"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 43344"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-009_b5d959b6dc59	RHEA:43345	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43344	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:43344"", ""source_assertion"": ""RHEA:43345 products contain CHEBI:33019 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43345 rh:products; http://rdf.rhea-db.org/43344_R rh:contains1 http://rdf.rhea-db.org/Participant_43344_compound_2106; rh:compound http://rdf.rhea-db.org/Compound_2106""}]"	"[{""id"": ""RHEA:43344"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 43344"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-010_977a002b699b	RHEA-COMP:12910	pathwaymech:consumes	RHEA:43341	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43340	Coefficient 1 in the selected biosynthetic direction. Whole protein carrier state is retained; the reactive ChEBI residue is not substituted for the protein.	"[{""reference_id"": ""RHEA:43340"", ""source_assertion"": ""RHEA:43341 substrates contain RHEA-COMP:12910 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43341 rh:substrates; http://rdf.rhea-db.org/43340_L rh:contains1 http://rdf.rhea-db.org/Participant_43340_compound_12910; rh:compound http://rdf.rhea-db.org/Compound_12910""}]"	"[{""id"": ""RHEA:43340"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 43340"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-011_cc7bec3ff535	RHEA-COMP:12157	pathwaymech:consumes	RHEA:43341	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43340	Coefficient 1 in the selected biosynthetic direction. Whole protein carrier state is retained; the reactive ChEBI residue is not substituted for the protein.	"[{""reference_id"": ""RHEA:43340"", ""source_assertion"": ""RHEA:43341 substrates contain RHEA-COMP:12157 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43341 rh:substrates; http://rdf.rhea-db.org/43340_L rh:contains1 http://rdf.rhea-db.org/Participant_43340_compound_12157; rh:compound http://rdf.rhea-db.org/Compound_12157""}]"	"[{""id"": ""RHEA:43340"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 43340"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-012_4d8f6a1d702a	CHEBI:17499	pathwaymech:consumes	RHEA:43341	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43340	Coefficient 1 in the selected biosynthetic direction. AH2/A are generic donor/acceptor classes, not an identified physiological reductant.	"[{""reference_id"": ""RHEA:43340"", ""source_assertion"": ""RHEA:43341 substrates contain CHEBI:17499 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43341 rh:substrates; http://rdf.rhea-db.org/43340_L rh:contains1 http://rdf.rhea-db.org/Participant_43340_compound_1304; rh:compound http://rdf.rhea-db.org/Compound_1304""}]"	"[{""id"": ""RHEA:43340"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 43340"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-013_ebfae8774153	RHEA:43341	pathwaymech:produces	RHEA-COMP:19908	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43340	Coefficient 1 in the selected biosynthetic direction. Whole protein carrier state is retained; the reactive ChEBI residue is not substituted for the protein.	"[{""reference_id"": ""RHEA:43340"", ""source_assertion"": ""RHEA:43341 products contain RHEA-COMP:19908 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43341 rh:products; http://rdf.rhea-db.org/43340_R rh:contains1 http://rdf.rhea-db.org/Participant_43340_compound_19908; rh:compound http://rdf.rhea-db.org/Compound_19908""}]"	"[{""id"": ""RHEA:43340"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 43340"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-014_63e328f7d90b	RHEA:43341	pathwaymech:produces	RHEA-COMP:12158	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43340	Coefficient 1 in the selected biosynthetic direction. Whole protein carrier state is retained; the reactive ChEBI residue is not substituted for the protein.	"[{""reference_id"": ""RHEA:43340"", ""source_assertion"": ""RHEA:43341 products contain RHEA-COMP:12158 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43341 rh:products; http://rdf.rhea-db.org/43340_R rh:contains1 http://rdf.rhea-db.org/Participant_43340_compound_12158; rh:compound http://rdf.rhea-db.org/Compound_12158""}]"	"[{""id"": ""RHEA:43340"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 43340"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-015_3a16ec34d8af	RHEA:43341	pathwaymech:produces	CHEBI:13193	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43340	Coefficient 1 in the selected biosynthetic direction. AH2/A are generic donor/acceptor classes, not an identified physiological reductant.	"[{""reference_id"": ""RHEA:43340"", ""source_assertion"": ""RHEA:43341 products contain CHEBI:13193 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43341 rh:products; http://rdf.rhea-db.org/43340_R rh:contains1 http://rdf.rhea-db.org/Participant_43340_compound_3512; rh:compound http://rdf.rhea-db.org/Compound_3512""}]"	"[{""id"": ""RHEA:43340"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 43340"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-016_20976160c5c2	RHEA:43341	pathwaymech:produces	CHEBI:456215	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43340	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:43340"", ""source_assertion"": ""RHEA:43341 products contain CHEBI:456215 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/43341 rh:products; http://rdf.rhea-db.org/43340_R rh:contains1 http://rdf.rhea-db.org/Participant_43340_compound_2590; rh:compound http://rdf.rhea-db.org/Compound_2590""}]"	"[{""id"": ""RHEA:43340"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 43340"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-017_82d21ad99f28	RHEA:43341	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:43340	Coefficient 2 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:43340"", ""source_assertion"": ""RHEA:43341 products contain CHEBI:15378 with coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/43341 rh:products; http://rdf.rhea-db.org/43340_R rh:contains2 http://rdf.rhea-db.org/Participant_43340_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249""}]"	"[{""id"": ""RHEA:43340"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 43340"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-018_c3d557eabb49	CHEBI:59776	pathwaymech:consumes	RHEA:12606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12605	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:12605"", ""source_assertion"": ""RHEA:12606 substrates contain CHEBI:59776 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/12606 rh:substrates; http://rdf.rhea-db.org/12605_L rh:contains1 http://rdf.rhea-db.org/Participant_12605_compound_6062; rh:compound http://rdf.rhea-db.org/Compound_6062""}]"	"[{""id"": ""RHEA:12605"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 12605"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-019_5d59b8e05b9f	CHEBI:15361	pathwaymech:consumes	RHEA:12606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12605	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:12605"", ""source_assertion"": ""RHEA:12606 substrates contain CHEBI:15361 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/12606 rh:substrates; http://rdf.rhea-db.org/12605_L rh:contains1 http://rdf.rhea-db.org/Participant_12605_compound_3719; rh:compound http://rdf.rhea-db.org/Compound_3719""}]"	"[{""id"": ""RHEA:12605"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 12605"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-020_afe902c15c0b	CHEBI:15378	pathwaymech:consumes	RHEA:12606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12605	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:12605"", ""source_assertion"": ""RHEA:12606 substrates contain CHEBI:15378 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/12606 rh:substrates; http://rdf.rhea-db.org/12605_L rh:contains1 http://rdf.rhea-db.org/Participant_12605_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249""}]"	"[{""id"": ""RHEA:12605"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 12605"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-021_26c2c84ee051	RHEA:12606	pathwaymech:produces	CHEBI:57792	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12605	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:12605"", ""source_assertion"": ""RHEA:12606 products contain CHEBI:57792 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/12606 rh:products; http://rdf.rhea-db.org/12605_R rh:contains1 http://rdf.rhea-db.org/Participant_12605_compound_2654; rh:compound http://rdf.rhea-db.org/Compound_2654""}]"	"[{""id"": ""RHEA:12605"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 12605"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-022_d352c479cdc2	RHEA:12606	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:12605	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:12605"", ""source_assertion"": ""RHEA:12606 products contain CHEBI:16526 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/12606 rh:products; http://rdf.rhea-db.org/12605_R rh:contains1 http://rdf.rhea-db.org/Participant_12605_compound_4391; rh:compound http://rdf.rhea-db.org/Compound_4391""}]"	"[{""id"": ""RHEA:12605"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 12605"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-023_dff96611138d	CHEBI:58315	pathwaymech:consumes	RHEA:26362	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26361	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:26361"", ""source_assertion"": ""RHEA:26362 substrates contain CHEBI:58315 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26362 rh:substrates; http://rdf.rhea-db.org/26361_L rh:contains1 http://rdf.rhea-db.org/Participant_26361_compound_1046; rh:compound http://rdf.rhea-db.org/Compound_1046""}]"	"[{""id"": ""RHEA:26361"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 26361"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-024_9184835bbcd3	CHEBI:59789	pathwaymech:consumes	RHEA:26362	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26361	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:26361"", ""source_assertion"": ""RHEA:26362 substrates contain CHEBI:59789 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26362 rh:substrates; http://rdf.rhea-db.org/26361_L rh:contains1 http://rdf.rhea-db.org/Participant_26361_compound_6127; rh:compound http://rdf.rhea-db.org/Compound_6127""}]"	"[{""id"": ""RHEA:26361"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 26361"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-025_d50d70bf0025	CHEBI:57783	pathwaymech:consumes	RHEA:26362	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26361	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:26361"", ""source_assertion"": ""RHEA:26362 substrates contain CHEBI:57783 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26362 rh:substrates; http://rdf.rhea-db.org/26361_L rh:contains1 http://rdf.rhea-db.org/Participant_26361_compound_3438; rh:compound http://rdf.rhea-db.org/Compound_3438""}]"	"[{""id"": ""RHEA:26361"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 26361"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-026_da1fc07399d6	RHEA:26362	pathwaymech:produces	CHEBI:77846	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26361	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:26361"", ""source_assertion"": ""RHEA:26362 products contain CHEBI:77846 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26362 rh:products; http://rdf.rhea-db.org/26361_R rh:contains1 http://rdf.rhea-db.org/Participant_26361_compound_9982; rh:compound http://rdf.rhea-db.org/Compound_9982""}]"	"[{""id"": ""RHEA:26361"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 26361"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-027_3537b95971cc	RHEA:26362	pathwaymech:produces	CHEBI:17847	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26361	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:26361"", ""source_assertion"": ""RHEA:26362 products contain CHEBI:17847 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26362 rh:products; http://rdf.rhea-db.org/26361_R rh:contains1 http://rdf.rhea-db.org/Participant_26361_compound_4232; rh:compound http://rdf.rhea-db.org/Compound_4232""}]"	"[{""id"": ""RHEA:26361"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 26361"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-028_27b339d04553	RHEA:26362	pathwaymech:produces	CHEBI:17319	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26361	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:26361"", ""source_assertion"": ""RHEA:26362 products contain CHEBI:17319 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26362 rh:products; http://rdf.rhea-db.org/26361_R rh:contains1 http://rdf.rhea-db.org/Participant_26361_compound_2028; rh:compound http://rdf.rhea-db.org/Compound_2028""}]"	"[{""id"": ""RHEA:26361"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 26361"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-029_d5f1d36650df	RHEA:26362	pathwaymech:produces	CHEBI:57844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26361	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:26361"", ""source_assertion"": ""RHEA:26362 products contain CHEBI:57844 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26362 rh:products; http://rdf.rhea-db.org/26361_R rh:contains1 http://rdf.rhea-db.org/Participant_26361_compound_2530; rh:compound http://rdf.rhea-db.org/Compound_2530""}]"	"[{""id"": ""RHEA:26361"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 26361"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-030_2114fb6b07d5	RHEA:26362	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26361	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:26361"", ""source_assertion"": ""RHEA:26362 products contain CHEBI:58349 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26362 rh:products; http://rdf.rhea-db.org/26361_R rh:contains1 http://rdf.rhea-db.org/Participant_26361_compound_5188; rh:compound http://rdf.rhea-db.org/Compound_5188""}]"	"[{""id"": ""RHEA:26361"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 26361"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-031_889ff136de46	RHEA-COMP:19908	pathwaymech:consumes	RHEA:26298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26297	Coefficient 1 in the selected biosynthetic direction. Whole protein carrier state is retained; the reactive ChEBI residue is not substituted for the protein.	"[{""reference_id"": ""RHEA:26297"", ""source_assertion"": ""RHEA:26298 substrates contain RHEA-COMP:19908 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26298 rh:substrates; http://rdf.rhea-db.org/26297_L rh:contains1 http://rdf.rhea-db.org/Participant_26297_compound_19908; rh:compound http://rdf.rhea-db.org/Compound_19908""}]"	"[{""id"": ""RHEA:26297"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 26297"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-032_34ff97c74f67	CHEBI:77846	pathwaymech:consumes	RHEA:26298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26297	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:26297"", ""source_assertion"": ""RHEA:26298 substrates contain CHEBI:77846 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26298 rh:substrates; http://rdf.rhea-db.org/26297_L rh:contains1 http://rdf.rhea-db.org/Participant_26297_compound_9982; rh:compound http://rdf.rhea-db.org/Compound_9982""}]"	"[{""id"": ""RHEA:26297"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 26297"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-033_4b0962a56b05	CHEBI:57792	pathwaymech:consumes	RHEA:26298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26297	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:26297"", ""source_assertion"": ""RHEA:26298 substrates contain CHEBI:57792 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26298 rh:substrates; http://rdf.rhea-db.org/26297_L rh:contains1 http://rdf.rhea-db.org/Participant_26297_compound_2654; rh:compound http://rdf.rhea-db.org/Compound_2654""}]"	"[{""id"": ""RHEA:26297"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 26297"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-034_6c60b8dd1cb9	RHEA:26298	pathwaymech:produces	RHEA-COMP:12909	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26297	Coefficient 1 in the selected biosynthetic direction. Whole protein carrier state is retained; the reactive ChEBI residue is not substituted for the protein.	"[{""reference_id"": ""RHEA:26297"", ""source_assertion"": ""RHEA:26298 products contain RHEA-COMP:12909 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26298 rh:products; http://rdf.rhea-db.org/26297_R rh:contains1 http://rdf.rhea-db.org/Participant_26297_compound_12909; rh:compound http://rdf.rhea-db.org/Compound_12909""}]"	"[{""id"": ""RHEA:26297"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 26297"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-035_2ec751fa73e1	RHEA:26298	pathwaymech:produces	CHEBI:62899	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26297	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:26297"", ""source_assertion"": ""RHEA:26298 products contain CHEBI:62899 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26298 rh:products; http://rdf.rhea-db.org/26297_R rh:contains1 http://rdf.rhea-db.org/Participant_26297_compound_6833; rh:compound http://rdf.rhea-db.org/Compound_6833""}]"	"[{""id"": ""RHEA:26297"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 26297"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-036_3492fa021439	RHEA:26298	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26297	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:26297"", ""source_assertion"": ""RHEA:26298 products contain CHEBI:15378 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26298 rh:products; http://rdf.rhea-db.org/26297_R rh:contains1 http://rdf.rhea-db.org/Participant_26297_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249""}]"	"[{""id"": ""RHEA:26297"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 26297"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-037_b69dc6a135a5	RHEA:26298	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26297	Coefficient 2 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:26297"", ""source_assertion"": ""RHEA:26298 products contain CHEBI:15377 with coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/26298 rh:products; http://rdf.rhea-db.org/26297_R rh:contains2 http://rdf.rhea-db.org/Participant_26297_compound_1283; rh:compound http://rdf.rhea-db.org/Compound_1283""}]"	"[{""id"": ""RHEA:26297"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 26297"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-038_eea7bc05a55b	CHEBI:137981	pathwaymech:consumes	RHEA:24841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24840	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:24840"", ""source_assertion"": ""RHEA:24841 substrates contain CHEBI:137981 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/24841 rh:substrates; http://rdf.rhea-db.org/24840_L rh:contains1 http://rdf.rhea-db.org/Participant_24840_compound_13720; rh:compound http://rdf.rhea-db.org/Compound_13720""}]"	"[{""id"": ""RHEA:24840"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 24840"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-039_c9a2a3bb22fe	CHEBI:59789	pathwaymech:consumes	RHEA:24841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24840	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:24840"", ""source_assertion"": ""RHEA:24841 substrates contain CHEBI:59789 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/24841 rh:substrates; http://rdf.rhea-db.org/24840_L rh:contains1 http://rdf.rhea-db.org/Participant_24840_compound_6127; rh:compound http://rdf.rhea-db.org/Compound_6127""}]"	"[{""id"": ""RHEA:24840"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 24840"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-040_e6f39f81269e	RHEA:24841	pathwaymech:produces	CHEBI:58354	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24840	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:24840"", ""source_assertion"": ""RHEA:24841 products contain CHEBI:58354 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/24841 rh:products; http://rdf.rhea-db.org/24840_R rh:contains1 http://rdf.rhea-db.org/Participant_24840_compound_1332; rh:compound http://rdf.rhea-db.org/Compound_1332""}]"	"[{""id"": ""RHEA:24840"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 24840"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-041_f8b46e4a1178	RHEA:24841	pathwaymech:produces	CHEBI:17245	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24840	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:24840"", ""source_assertion"": ""RHEA:24841 products contain CHEBI:17245 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/24841 rh:products; http://rdf.rhea-db.org/24840_R rh:contains1 http://rdf.rhea-db.org/Participant_24840_compound_7041; rh:compound http://rdf.rhea-db.org/Compound_7041""}]"	"[{""id"": ""RHEA:24840"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 24840"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-042_7a6547c70ddb	RHEA:24841	pathwaymech:produces	CHEBI:17319	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24840	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:24840"", ""source_assertion"": ""RHEA:24841 products contain CHEBI:17319 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/24841 rh:products; http://rdf.rhea-db.org/24840_R rh:contains1 http://rdf.rhea-db.org/Participant_24840_compound_2028; rh:compound http://rdf.rhea-db.org/Compound_2028""}]"	"[{""id"": ""RHEA:24840"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 24840"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-043_e06babb3f016	RHEA:24841	pathwaymech:produces	CHEBI:15740	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24840	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:24840"", ""source_assertion"": ""RHEA:24841 products contain CHEBI:15740 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/24841 rh:products; http://rdf.rhea-db.org/24840_R rh:contains1 http://rdf.rhea-db.org/Participant_24840_compound_3001; rh:compound http://rdf.rhea-db.org/Compound_3001""}]"	"[{""id"": ""RHEA:24840"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 24840"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-044_4e2c9986feed	RHEA:24841	pathwaymech:produces	CHEBI:57844	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24840	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:24840"", ""source_assertion"": ""RHEA:24841 products contain CHEBI:57844 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/24841 rh:products; http://rdf.rhea-db.org/24840_R rh:contains1 http://rdf.rhea-db.org/Participant_24840_compound_2530; rh:compound http://rdf.rhea-db.org/Compound_2530""}]"	"[{""id"": ""RHEA:24840"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 24840"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-045_ce595dfd087a	RHEA:24841	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24840	Coefficient 3 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:24840"", ""source_assertion"": ""RHEA:24841 products contain CHEBI:15378 with coefficient 3."", ""source_locator"": ""http://rdf.rhea-db.org/24841 rh:products; http://rdf.rhea-db.org/24840_R rh:contains3 http://rdf.rhea-db.org/Participant_24840_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249""}]"	"[{""id"": ""RHEA:24840"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 24840"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-046_80e851a19801	CHEBI:58354	pathwaymech:consumes	RHEA:19894	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19893	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:19893"", ""source_assertion"": ""RHEA:19894 substrates contain CHEBI:58354 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/19894 rh:substrates; http://rdf.rhea-db.org/19893_L rh:contains1 http://rdf.rhea-db.org/Participant_19893_compound_1332; rh:compound http://rdf.rhea-db.org/Compound_1332""}]"	"[{""id"": ""RHEA:19893"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 19893"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-047_214b8983dd33	CHEBI:30616	pathwaymech:consumes	RHEA:19894	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19893	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:19893"", ""source_assertion"": ""RHEA:19894 substrates contain CHEBI:30616 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/19894 rh:substrates; http://rdf.rhea-db.org/19893_L rh:contains1 http://rdf.rhea-db.org/Participant_19893_compound_6372; rh:compound http://rdf.rhea-db.org/Compound_6372""}]"	"[{""id"": ""RHEA:19893"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 19893"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-048_0e913cbd346d	RHEA:19894	pathwaymech:produces	CHEBI:57841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19893	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:19893"", ""source_assertion"": ""RHEA:19894 products contain CHEBI:57841 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/19894 rh:products; http://rdf.rhea-db.org/19893_R rh:contains1 http://rdf.rhea-db.org/Participant_19893_compound_4541; rh:compound http://rdf.rhea-db.org/Compound_4541""}]"	"[{""id"": ""RHEA:19893"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 19893"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-049_8791f2f1c1b5	RHEA:19894	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:19893	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:19893"", ""source_assertion"": ""RHEA:19894 products contain CHEBI:456216 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/19894 rh:products; http://rdf.rhea-db.org/19893_R rh:contains1 http://rdf.rhea-db.org/Participant_19893_compound_2710; rh:compound http://rdf.rhea-db.org/Compound_2710""}]"	"[{""id"": ""RHEA:19893"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 19893"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-050_ad337c72671d	CHEBI:62899	pathwaymech:consumes	RHEA:47845	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47844	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:47844"", ""source_assertion"": ""RHEA:47845 substrates contain CHEBI:62899 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/47845 rh:substrates; http://rdf.rhea-db.org/47844_L rh:contains1 http://rdf.rhea-db.org/Participant_47844_compound_6833; rh:compound http://rdf.rhea-db.org/Compound_6833""}]"	"[{""id"": ""RHEA:47844"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 47844"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-051_0bb403bc10e2	CHEBI:57841	pathwaymech:consumes	RHEA:47845	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47844	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:47844"", ""source_assertion"": ""RHEA:47845 substrates contain CHEBI:57841 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/47845 rh:substrates; http://rdf.rhea-db.org/47844_L rh:contains1 http://rdf.rhea-db.org/Participant_47844_compound_4541; rh:compound http://rdf.rhea-db.org/Compound_4541""}]"	"[{""id"": ""RHEA:47844"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 47844"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-052_acbd7565ec04	CHEBI:15378	pathwaymech:consumes	RHEA:47845	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47844	Coefficient 2 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:47844"", ""source_assertion"": ""RHEA:47845 substrates contain CHEBI:15378 with coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/47845 rh:substrates; http://rdf.rhea-db.org/47844_L rh:contains2 http://rdf.rhea-db.org/Participant_47844_compound_3249; rh:compound http://rdf.rhea-db.org/Compound_3249""}]"	"[{""id"": ""RHEA:47844"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 47844"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-053_0eb5b2a8c5b8	RHEA:47845	pathwaymech:produces	CHEBI:37575	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47844	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:47844"", ""source_assertion"": ""RHEA:47845 products contain CHEBI:37575 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/47845 rh:products; http://rdf.rhea-db.org/47844_R rh:contains1 http://rdf.rhea-db.org/Participant_47844_compound_5658; rh:compound http://rdf.rhea-db.org/Compound_5658""}]"	"[{""id"": ""RHEA:47844"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 47844"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-054_ef2d5e18ff6e	RHEA:47845	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47844	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:47844"", ""source_assertion"": ""RHEA:47845 products contain CHEBI:16526 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/47845 rh:products; http://rdf.rhea-db.org/47844_R rh:contains1 http://rdf.rhea-db.org/Participant_47844_compound_4391; rh:compound http://rdf.rhea-db.org/Compound_4391""}]"	"[{""id"": ""RHEA:47844"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 47844"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-055_87e68e0805f9	RHEA:47845	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:47844	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:47844"", ""source_assertion"": ""RHEA:47845 products contain CHEBI:33019 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/47845 rh:products; http://rdf.rhea-db.org/47844_R rh:contains1 http://rdf.rhea-db.org/Participant_47844_compound_2106; rh:compound http://rdf.rhea-db.org/Compound_2106""}]"	"[{""id"": ""RHEA:47844"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 47844"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-056_c42c2df92cd0	CHEBI:37575	pathwaymech:consumes	RHEA:15914	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15913	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:15913"", ""source_assertion"": ""RHEA:15914 substrates contain CHEBI:37575 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/15914 rh:substrates; http://rdf.rhea-db.org/15913_L rh:contains1 http://rdf.rhea-db.org/Participant_15913_compound_5658; rh:compound http://rdf.rhea-db.org/Compound_5658""}]"	"[{""id"": ""RHEA:15913"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 15913"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-057_607f2b8d420e	CHEBI:30616	pathwaymech:consumes	RHEA:15914	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15913	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:15913"", ""source_assertion"": ""RHEA:15914 substrates contain CHEBI:30616 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/15914 rh:substrates; http://rdf.rhea-db.org/15913_L rh:contains1 http://rdf.rhea-db.org/Participant_15913_compound_6372; rh:compound http://rdf.rhea-db.org/Compound_6372""}]"	"[{""id"": ""RHEA:15913"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 15913"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-058_a5709b565389	RHEA:15914	pathwaymech:produces	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15913	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:15913"", ""source_assertion"": ""RHEA:15914 products contain CHEBI:58937 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/15914 rh:products; http://rdf.rhea-db.org/15913_R rh:contains1 http://rdf.rhea-db.org/Participant_15913_compound_5328; rh:compound http://rdf.rhea-db.org/Compound_5328""}]"	"[{""id"": ""RHEA:15913"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 15913"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-059_ad7af8d5afb2	RHEA:15914	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:15913	Coefficient 1 in the selected biosynthetic direction.	"[{""reference_id"": ""RHEA:15913"", ""source_assertion"": ""RHEA:15914 products contain CHEBI:456216 with coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/15914 rh:products; http://rdf.rhea-db.org/15913_R rh:contains1 http://rdf.rhea-db.org/Participant_15913_compound_2710; rh:compound http://rdf.rhea-db.org/Compound_2710""}]"	"[{""id"": ""RHEA:15913"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 15913"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-060_85365f557466	RHEA:17458	BFO:0000050	MetaCyc:THISYN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6892|MetaCyc:RXN0-308|RHEA:17457	Native child-pathway membership is joined to the independently resolved current Rhea family; left-to-right is source orientation, not thermodynamic irreversibility.	"[{""reference_id"": ""MetaCyc:PWY-6892"", ""source_assertion"": ""PWY-6892 lists RXN0-308; THISYN-PWY includes this child pathway."", ""source_locator"": ""Pathway[@frameid=\""PWY-6892\""]/reaction-list; super-pathways/Pathway[@frameid=\""THISYN-PWY\""]""}, {""reference_id"": ""MetaCyc:RXN0-308"", ""source_assertion"": ""RXN0-308 links to RHEA:17458."", ""source_locator"": ""Reaction/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:17457"", ""source_assertion"": ""RHEA:17457 has biosynthetically selected directional reaction RHEA:17458; the native cross-reference RHEA:17458 belongs to this family."", ""source_locator"": ""http://rdf.rhea-db.org/17457 rh:directionalReaction and rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:PWY-6892"", ""source_sha256"": ""c2677fa25d5cb114ce46042a8de2532d8c6d85a476449e8d419b3783d16ecb55"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""thiazole biosynthesis I (facultative anaerobic bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6892""}, {""id"": ""MetaCyc:RXN0-308"", ""source_sha256"": ""b7cfc31659f90f5637ad8ae269cc09868a47e8c7205b2e18398fadaa6331723c"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""RXN0-308"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-308""}, {""id"": ""RHEA:17457"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 17457"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-061_be3b184e64e7	RHEA:43345	BFO:0000050	MetaCyc:THISYN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6892|MetaCyc:RXN-9789|RHEA:43344	Native child-pathway membership is joined to the independently resolved current Rhea family; left-to-right is source orientation, not thermodynamic irreversibility.	"[{""reference_id"": ""MetaCyc:PWY-6892"", ""source_assertion"": ""PWY-6892 lists RXN-9789; THISYN-PWY includes this child pathway."", ""source_locator"": ""Pathway[@frameid=\""PWY-6892\""]/reaction-list; super-pathways/Pathway[@frameid=\""THISYN-PWY\""]""}, {""reference_id"": ""MetaCyc:RXN-9789"", ""source_assertion"": ""RXN-9789 links to RHEA:43345."", ""source_locator"": ""Reaction/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:43344"", ""source_assertion"": ""RHEA:43344 has biosynthetically selected directional reaction RHEA:43345; the native cross-reference RHEA:43345 belongs to this family."", ""source_locator"": ""http://rdf.rhea-db.org/43344 rh:directionalReaction and rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:PWY-6892"", ""source_sha256"": ""c2677fa25d5cb114ce46042a8de2532d8c6d85a476449e8d419b3783d16ecb55"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""thiazole biosynthesis I (facultative anaerobic bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6892""}, {""id"": ""MetaCyc:RXN-9789"", ""source_sha256"": ""c702b30a85e578e6dac47a72939e8abc33431069b40cf00df288b829309ba086"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""RXN-9789"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-9789""}, {""id"": ""RHEA:43344"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 43344"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-062_8463c4733ca0	RHEA:12606	BFO:0000050	MetaCyc:THISYN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DXS-RXN|MetaCyc:PWY-6892|RHEA:12605	Native child-pathway membership is joined to the independently resolved current Rhea family; left-to-right is source orientation, not thermodynamic irreversibility.	"[{""reference_id"": ""MetaCyc:PWY-6892"", ""source_assertion"": ""PWY-6892 lists DXS-RXN; THISYN-PWY includes this child pathway."", ""source_locator"": ""Pathway[@frameid=\""PWY-6892\""]/reaction-list; super-pathways/Pathway[@frameid=\""THISYN-PWY\""]""}, {""reference_id"": ""MetaCyc:DXS-RXN"", ""source_assertion"": ""DXS-RXN links to RHEA:12606."", ""source_locator"": ""Reaction/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:12605"", ""source_assertion"": ""RHEA:12605 has biosynthetically selected directional reaction RHEA:12606; the native cross-reference RHEA:12606 belongs to this family."", ""source_locator"": ""http://rdf.rhea-db.org/12605 rh:directionalReaction and rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:DXS-RXN"", ""source_sha256"": ""292dfef23c335de0431dfa3d253cedea1cb5456c245590fdf08c12b9dddb0c5f"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""DXS-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DXS-RXN""}, {""id"": ""MetaCyc:PWY-6892"", ""source_sha256"": ""c2677fa25d5cb114ce46042a8de2532d8c6d85a476449e8d419b3783d16ecb55"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""thiazole biosynthesis I (facultative anaerobic bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6892""}, {""id"": ""RHEA:12605"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 12605"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-063_2e1cc540b0b6	RHEA:26362	BFO:0000050	MetaCyc:THISYN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6892|MetaCyc:RXN-11319|RHEA:26361	Native child-pathway membership is joined to the independently resolved current Rhea family; left-to-right is source orientation, not thermodynamic irreversibility.	"[{""reference_id"": ""MetaCyc:PWY-6892"", ""source_assertion"": ""PWY-6892 lists RXN-11319; THISYN-PWY includes this child pathway."", ""source_locator"": ""Pathway[@frameid=\""PWY-6892\""]/reaction-list; super-pathways/Pathway[@frameid=\""THISYN-PWY\""]""}, {""reference_id"": ""MetaCyc:RXN-11319"", ""source_assertion"": ""RXN-11319 links to RHEA:26364."", ""source_locator"": ""Reaction/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:26361"", ""source_assertion"": ""RHEA:26361 has biosynthetically selected directional reaction RHEA:26362; the native cross-reference RHEA:26364 belongs to this family."", ""source_locator"": ""http://rdf.rhea-db.org/26361 rh:directionalReaction and rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:PWY-6892"", ""source_sha256"": ""c2677fa25d5cb114ce46042a8de2532d8c6d85a476449e8d419b3783d16ecb55"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""thiazole biosynthesis I (facultative anaerobic bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6892""}, {""id"": ""MetaCyc:RXN-11319"", ""source_sha256"": ""4c87b4447da267ae8766afe33c7a3f04004bc1c81a9f9f89a20dac6ab8d6d42a"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""RXN-11319"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-11319""}, {""id"": ""RHEA:26361"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 26361"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-064_4c0573957b54	RHEA:26298	BFO:0000050	MetaCyc:THISYN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6892|MetaCyc:THIAZOLSYN2-RXN|RHEA:26297	Native child-pathway membership is joined to the independently resolved current Rhea family; left-to-right is source orientation, not thermodynamic irreversibility.	"[{""reference_id"": ""MetaCyc:PWY-6892"", ""source_assertion"": ""PWY-6892 lists THIAZOLSYN2-RXN; THISYN-PWY includes this child pathway."", ""source_locator"": ""Pathway[@frameid=\""PWY-6892\""]/reaction-list; super-pathways/Pathway[@frameid=\""THISYN-PWY\""]""}, {""reference_id"": ""MetaCyc:THIAZOLSYN2-RXN"", ""source_assertion"": ""THIAZOLSYN2-RXN links to RHEA:26300."", ""source_locator"": ""Reaction/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:26297"", ""source_assertion"": ""RHEA:26297 has biosynthetically selected directional reaction RHEA:26298; the native cross-reference RHEA:26300 belongs to this family."", ""source_locator"": ""http://rdf.rhea-db.org/26297 rh:directionalReaction and rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:PWY-6892"", ""source_sha256"": ""c2677fa25d5cb114ce46042a8de2532d8c6d85a476449e8d419b3783d16ecb55"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""thiazole biosynthesis I (facultative anaerobic bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6892""}, {""id"": ""MetaCyc:THIAZOLSYN2-RXN"", ""source_sha256"": ""a834d4f02fd4bf112c082dcb7c7dba4551531ab09df3e4b29cb8e0d2e3b41fdf"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""THIAZOLSYN2-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:THIAZOLSYN2-RXN""}, {""id"": ""RHEA:26297"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 26297"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-065_a77681779964	RHEA:24841	BFO:0000050	MetaCyc:THISYN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6890|MetaCyc:PYRIMSYN1-RXN|RHEA:24840	Native child-pathway membership is joined to the independently resolved current Rhea family; left-to-right is source orientation, not thermodynamic irreversibility.	"[{""reference_id"": ""MetaCyc:PWY-6890"", ""source_assertion"": ""PWY-6890 lists PYRIMSYN1-RXN; THISYN-PWY includes this child pathway."", ""source_locator"": ""Pathway[@frameid=\""PWY-6890\""]/reaction-list; super-pathways/Pathway[@frameid=\""THISYN-PWY\""]""}, {""reference_id"": ""MetaCyc:PYRIMSYN1-RXN"", ""source_assertion"": ""PYRIMSYN1-RXN links to RHEA:24841."", ""source_locator"": ""Reaction/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:24840"", ""source_assertion"": ""RHEA:24840 has biosynthetically selected directional reaction RHEA:24841; the native cross-reference RHEA:24841 belongs to this family."", ""source_locator"": ""http://rdf.rhea-db.org/24840 rh:directionalReaction and rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:PWY-6890"", ""source_sha256"": ""732ff15b7721e69b6aad4b5deca0548ca48c8f9063bf4f69dc6063bea9f33391"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6890""}, {""id"": ""MetaCyc:PYRIMSYN1-RXN"", ""source_sha256"": ""720434e9a13e52672ee111cd3f18f38eaf57a88b69cd75a976f9aeeaa9e2ae7c"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""PYRIMSYN1-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PYRIMSYN1-RXN""}, {""id"": ""RHEA:24840"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 24840"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-066_741e27be24bf	RHEA:19894	BFO:0000050	MetaCyc:THISYN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6890|MetaCyc:PYRIMSYN3-RXN|RHEA:19893	Native child-pathway membership is joined to the independently resolved current Rhea family; left-to-right is source orientation, not thermodynamic irreversibility.	"[{""reference_id"": ""MetaCyc:PWY-6890"", ""source_assertion"": ""PWY-6890 lists PYRIMSYN3-RXN; THISYN-PWY includes this child pathway."", ""source_locator"": ""Pathway[@frameid=\""PWY-6890\""]/reaction-list; super-pathways/Pathway[@frameid=\""THISYN-PWY\""]""}, {""reference_id"": ""MetaCyc:PYRIMSYN3-RXN"", ""source_assertion"": ""PYRIMSYN3-RXN links to RHEA:19894."", ""source_locator"": ""Reaction/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:19893"", ""source_assertion"": ""RHEA:19893 has biosynthetically selected directional reaction RHEA:19894; the native cross-reference RHEA:19894 belongs to this family."", ""source_locator"": ""http://rdf.rhea-db.org/19893 rh:directionalReaction and rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:PWY-6890"", ""source_sha256"": ""732ff15b7721e69b6aad4b5deca0548ca48c8f9063bf4f69dc6063bea9f33391"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6890""}, {""id"": ""MetaCyc:PYRIMSYN3-RXN"", ""source_sha256"": ""e952b8e7e467ffd1eccb88ed0650c2b194ed1291dc5de45d5d079da4c50b65cd"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""PYRIMSYN3-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PYRIMSYN3-RXN""}, {""id"": ""RHEA:19893"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 19893"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-067_bfeb95a9bb41	RHEA:47845	BFO:0000050	MetaCyc:THISYN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6894|MetaCyc:RXN-12611|RHEA:47844	Native child-pathway membership is joined to the independently resolved current Rhea family; left-to-right is source orientation, not thermodynamic irreversibility.	"[{""reference_id"": ""MetaCyc:PWY-6894"", ""source_assertion"": ""PWY-6894 lists RXN-12611; THISYN-PWY includes this child pathway."", ""source_locator"": ""Pathway[@frameid=\""PWY-6894\""]/reaction-list; super-pathways/Pathway[@frameid=\""THISYN-PWY\""]""}, {""reference_id"": ""MetaCyc:RXN-12611"", ""source_assertion"": ""RXN-12611 links to RHEA:47845."", ""source_locator"": ""Reaction/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:47844"", ""source_assertion"": ""RHEA:47844 has biosynthetically selected directional reaction RHEA:47845; the native cross-reference RHEA:47845 belongs to this family."", ""source_locator"": ""http://rdf.rhea-db.org/47844 rh:directionalReaction and rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:PWY-6894"", ""source_sha256"": ""2ddbf01cc0504f33f5cad5c371a2d4f8d2c793d93d5bf1512c3089ae1212a4fd"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""thiamine diphosphate biosynthesis I (E. coli)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6894""}, {""id"": ""MetaCyc:RXN-12611"", ""source_sha256"": ""eeed5dd2b07d0e7d4c0f42db888b8e49f2629f0e7b03ab89e72409e6024415e7"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""thiamin phosphate synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-12611""}, {""id"": ""RHEA:47844"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 47844"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-068_59fce4eb8966	RHEA:15914	BFO:0000050	MetaCyc:THISYN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6894|MetaCyc:THI-P-KIN-RXN|RHEA:15913	Native child-pathway membership is joined to the independently resolved current Rhea family; left-to-right is source orientation, not thermodynamic irreversibility.	"[{""reference_id"": ""MetaCyc:PWY-6894"", ""source_assertion"": ""PWY-6894 lists THI-P-KIN-RXN; THISYN-PWY includes this child pathway."", ""source_locator"": ""Pathway[@frameid=\""PWY-6894\""]/reaction-list; super-pathways/Pathway[@frameid=\""THISYN-PWY\""]""}, {""reference_id"": ""MetaCyc:THI-P-KIN-RXN"", ""source_assertion"": ""THI-P-KIN-RXN links to RHEA:15914."", ""source_locator"": ""Reaction/dblink[dblink-db='RHEA']/dblink-oid""}, {""reference_id"": ""RHEA:15913"", ""source_assertion"": ""RHEA:15913 has biosynthetically selected directional reaction RHEA:15914; the native cross-reference RHEA:15914 belongs to this family."", ""source_locator"": ""http://rdf.rhea-db.org/15913 rh:directionalReaction and rh:bidirectionalReaction""}]"	"[{""id"": ""MetaCyc:PWY-6894"", ""source_sha256"": ""2ddbf01cc0504f33f5cad5c371a2d4f8d2c793d93d5bf1512c3089ae1212a4fd"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""thiamine diphosphate biosynthesis I (E. coli)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6894""}, {""id"": ""MetaCyc:THI-P-KIN-RXN"", ""source_sha256"": ""ebde39a8dd8a2b27af4cf3ff66ae1405e7c0ba96ee4ad1118f17f03bfd4b853a"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""THI-P-KIN-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:THI-P-KIN-RXN""}, {""id"": ""RHEA:15913"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 15913"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-069_242bc6595040	RHEA:43341	BFO:0000050	MetaCyc:THISYN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-6892|RHEA:43340|UniProtKB:P77718	One current net sulfur-transfer reaction replaces the native two-step ThiI relay (RXN-14382 and RXN-9788). It retains IscS and ThiS carrier states but does not separately assert transient ThiI persulfide, ThiI/ThiF acyldisulfides, or specific ferredoxin chemistry.	"[{""reference_id"": ""MetaCyc:PWY-6892"", ""source_assertion"": ""PWY-6892 contains RXN-14382 and RXN-9788 for sulfur delivery from persulfidated cysteine desulfurase via ThiI to adenylated ThiS."", ""source_locator"": ""Pathway/reaction-list; comment, About This Pathway""}, {""reference_id"": ""UniProtKB:P77718"", ""source_assertion"": ""ThiI is annotated with net RHEA:43340. Its attached PMID10753862 is a tRNA study and is not treated as direct evidence for ThiS chemistry."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY']""}, {""reference_id"": ""RHEA:43340"", ""source_assertion"": ""RHEA:43341 is the left-to-right direction of net ThiS thiocarboxylation, including generic donor AH2 and acceptor A."", ""source_locator"": ""http://rdf.rhea-db.org/43340 rh:directionalReaction; http://rdf.rhea-db.org/43341 rh:substrates and rh:products""}]"	"[{""id"": ""MetaCyc:PWY-6892"", ""source_sha256"": ""c2677fa25d5cb114ce46042a8de2532d8c6d85a476449e8d419b3783d16ecb55"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""thiazole biosynthesis I (facultative anaerobic bacteria)"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:PWY-6892""}, {""id"": ""RHEA:43340"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142, 2026-09-02; SHA-256 covers the complete compressed official RDF artifact"", ""title"": ""Rhea reaction family 43340"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P77718"", ""source_sha256"": ""fc887ae13aa3ed4248a165a6b1fd5dbbbbe170a06900b475be6072da4967bcea"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 180; actual body digest"", ""title"": ""tRNA sulfurtransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77718.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-070_5b34ed40689c	MetaCyc:CPLX0-248	pathwaymech:catalyzes	RHEA:17458	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN0-308|PMID:12860127	IscS performs PLP-dependent cysteine desulfuration through its protein persulfide. The protein carrier class represents this catalytic state, not an additional freely diffusible metabolite.	"[{""reference_id"": ""MetaCyc:RXN0-308"", ""source_assertion"": ""ENZRXN0-251 assigns RXN0-308 to IscS complex CPLX0-248."", ""source_locator"": ""Reaction/enzymatic-reaction/Enzymatic-Reaction[@frameid=\""ENZRXN0-251\""]/enzyme""}, {""quote"": ""IscS is a widely distributed cysteine desulfurase that catalyzes the pyridoxal phosphate-dependent desulfuration of L-cysteine"", ""reference_id"": ""PMID:12860127""}]"	"[{""id"": ""MetaCyc:RXN0-308"", ""source_sha256"": ""b7cfc31659f90f5637ad8ae269cc09868a47e8c7205b2e18398fadaa6331723c"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""RXN0-308"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-308""}, {""id"": ""PMID:12860127"", ""source_sha256"": ""47eb456e0df691e19e6f6b2e1c54db296c739e7fc4439075f329ae74aa428152"", ""source_version"": ""Europe PMC indexed primary abstract and metadata retrieved 2026-10-11; not a full-text digest"", ""title"": ""Crystal structure of IscS, a cysteine desulfurase from Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12860127%20AND%20SRC:MED&format=xml&resultType=core""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-071_772220537fc1	UniProtKB:P30138	pathwaymech:enables	RHEA:43345	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:16388576|PMID:9632726|UniProtKB:P30138	Functional ThiF enables ThiS adenylation; ThiF is homodimeric and ThiS-bound crystal assemblies contain two ThiF and two ThiS molecules. This gene-product edge does not assert monomer sufficiency.	"[{""reference_id"": ""UniProtKB:P30138"", ""source_assertion"": ""ThiF catalyzes RHEA:43344 adenylation of terminal Gly-Gly on ThiS; ECO:0000269, PMID9632726."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY']""}, {""quote"": ""ThiF catalyzes the adenylation by ATP of the carboxyl-terminal glycine of ThiS."", ""reference_id"": ""PMID:9632726""}, {""reference_id"": ""UniProtKB:P30138"", ""source_assertion"": ""ThiF is a homodimer; ECO:0000269, PMIDs15896804 and16388576."", ""source_locator"": ""comments[commentType='SUBUNIT']""}, {""quote"": ""ThiS-ThiF is a heterotetramer consisting of a dimer of heterodimers."", ""reference_id"": ""PMID:16388576""}]"	"[{""id"": ""PMID:16388576"", ""source_sha256"": ""eef53bd9f39e6d70f238f2dda0985e22d7af189785315d1531edebe9cf27d1e1"", ""source_version"": ""PMC full article HTML retrieved 2026-10-11; actual HTML digest"", ""title"": ""Structure of the Escherichia coli ThiS-ThiF complex, a key component of the sulfur transfer system in thiamin biosynthesis"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2566941/""}, {""id"": ""PMID:9632726"", ""source_sha256"": ""1a497d37747d48bc9c18dc8250828852b4383bc38754442eb6884cc1dafc2fc1"", ""source_version"": ""Europe PMC indexed primary abstract and metadata retrieved 2026-10-11; not a full-text digest"", ""title"": ""Thiamin biosynthesis in Escherichia coli. Identification of ThiS thiocarboxylate as the immediate sulfur donor in the thiazole formation."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9632726%20AND%20SRC:MED&format=xml&resultType=core""}, {""id"": ""UniProtKB:P30138"", ""source_sha256"": ""5e98839c0742e8f4af9469f8af50f9fd033adc67bb5edf10900ca174023eee89"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 187; actual body digest"", ""title"": ""Sulfur carrier protein ThiS adenylyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30138.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-072_7900c185990b	UniProtKB:P77718	pathwaymech:enables	RHEA:43341	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:10781607|UniProtKB:P77718	ThiI contributes to net sulfur transfer in the E. coli pathway. The primary reconstitution reports sevenfold stimulation, not isolated ThiI sufficiency or absolute requirement in every in vitro condition. The physiological reductant remains unspecified.	"[{""reference_id"": ""UniProtKB:P77718"", ""source_assertion"": ""ThiI is annotated to transfer sulfur to ThiS, forming ThiS-thiocarboxylate, with sulfur donated as IscS persulfide."", ""source_locator"": ""comments[commentType='FUNCTION']""}, {""quote"": ""ThiI, a known factor involved in both thiazole and s(4)U synthesis, stimulates this sulfur transfer step by 7-fold."", ""reference_id"": ""PMID:10781607""}]"	"[{""id"": ""PMID:10781607"", ""source_sha256"": ""a8e548a66d6102fb77b74fe5060d3233c3a8dbda20214b7f3e13cbafc16b92e0"", ""source_version"": ""Europe PMC indexed primary abstract and metadata retrieved 2026-10-11; not a full-text digest"", ""title"": ""The iscS gene in Escherichia coli is required for the biosynthesis of 4-thiouridine, thiamin, and NAD."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10781607%20AND%20SRC:MED&format=xml&resultType=core""}, {""id"": ""UniProtKB:P77718"", ""source_sha256"": ""fc887ae13aa3ed4248a165a6b1fd5dbbbbe170a06900b475be6072da4967bcea"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 180; actual body digest"", ""title"": ""tRNA sulfurtransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77718.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-073_9b76afe666c6	UniProtKB:P0A6B7	pathwaymech:enables	RHEA:43341	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:11438688|UniProtKB:P0A6B7	IscS supplies sulfur for ThiS thiocarboxylation; the upstream desulfuration and this net transfer are distinct transformations. IscS/ThiF reconstitution can produce ThiS-COSH without ThiI under its assay conditions.	"[{""quote"": ""ThiS-COSH formation has been successfully reconstituted in vitro"", ""reference_id"": ""PMID:11438688""}, {""reference_id"": ""UniProtKB:P0A6B7"", ""source_assertion"": ""IscS delivers sulfur to partner proteins and transfers sulfur onto ThiI Cys-456; direct-study annotations include PMID10781607."", ""source_locator"": ""comments[commentType='FUNCTION']""}]"	"[{""id"": ""PMID:11438688"", ""source_sha256"": ""d17a1a424002af073abbcec74b1f0134936d270ec100daa00f594a3ecaba3f85"", ""source_version"": ""PMC full article HTML retrieved 2026-10-11; actual HTML digest"", ""title"": ""Biosynthesis of the thiazole moiety of thiamin in Escherichia coli: Identification of an acyldisulfide-linked protein–protein conjugate that is functionally analogous to the ubiquitin/E1 complex"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC37467/""}, {""id"": ""UniProtKB:P0A6B7"", ""source_sha256"": ""a0d3b03558f20344c51483645cc0686eec98b255dcfe98c218bbb32d698ebc62"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 162; actual body digest"", ""title"": ""Cysteine desulfurase IscS"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6B7.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-074_60d56100ba2f	UniProtKB:O32583	pathwaymech:enables	MetaCyc:THISYN-PWY	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:O32583	ThiS is the sulfur-carrier gene product. The three Rhea whole-protein state nodes distinguish its carboxylate, adenylate and thiocarboxylate forms; this role does not identify all state-class instances with one accession.	"[{""reference_id"": ""UniProtKB:O32583"", ""source_assertion"": ""ThiS is the sulfur donor for the thiazole phosphate moiety; ECO:0000269, PMID9632726."", ""source_locator"": ""comments[commentType='FUNCTION']""}, {""reference_id"": ""UniProtKB:O32583"", ""source_assertion"": ""C-terminal thiocarboxylation proceeds via ThiF-dependent acyl adenylation and sulfur transfer; ECO:0000269, PMID9632726."", ""source_locator"": ""comments[commentType='PTM']""}]"	"[{""id"": ""UniProtKB:O32583"", ""source_sha256"": ""fb9c9a3611f87bc70c06405d195ded6e9ca42d3f3aa04138e40d9f22bbc7c662"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 161; actual body digest"", ""title"": ""Sulfur carrier protein ThiS"", ""url"": ""https://rest.uniprot.org/uniprotkb/O32583.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-075_ecf106d72979	MetaCyc:CPLX0-743	pathwaymech:catalyzes	RHEA:12606	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:DXS-RXN|UniProtKB:P77488	Dxs supplies the DXP branch input and requires thiamine diphosphate itself; pathway connectivity does not imply cofactor-free initiation.	"[{""reference_id"": ""MetaCyc:DXS-RXN"", ""source_assertion"": ""ENZRXN0-1021 assigns DXS-RXN to CPLX0-743."", ""source_locator"": ""Reaction/enzymatic-reaction/Enzymatic-Reaction[@frameid=\""ENZRXN0-1021\""]/enzyme""}, {""reference_id"": ""UniProtKB:P77488"", ""source_assertion"": ""Dxs catalyzes RHEA:12605; the annotated physiological direction is RHEA:12606. ECO:0000269 catalytic evidence: PMIDs9371765 and9482846."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY']""}]"	"[{""id"": ""MetaCyc:DXS-RXN"", ""source_sha256"": ""292dfef23c335de0431dfa3d253cedea1cb5456c245590fdf08c12b9dddb0c5f"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""DXS-RXN"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DXS-RXN""}, {""id"": ""UniProtKB:P77488"", ""source_sha256"": ""5628fe96cf93c95aaa5241f0733dd0fdb541ef3d93e92cac805397ba64e5f848"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 199; actual body digest"", ""title"": ""1-deoxy-D-xylulose-5-phosphate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77488.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-076_466364e5d946	MetaCyc:CPLX0-3949	pathwaymech:catalyzes	RHEA:26362	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:19923213|UniProtKB:P30140	ThiH within isolated ThiGH cleaves tyrosine using radical SAM chemistry. NADPH is the net reductant; primary assays used NADPH, flavodoxin 1 and flavoprotein:NADPH oxidoreductase under anaerobic conditions. These auxiliary assay proteins are not separately asserted pathway catalysts.	"[{""reference_id"": ""UniProtKB:P30140"", ""source_assertion"": ""ThiH catalyzes RHEA:26361; ECO:0000269, PMIDs17403671 and17969213."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY']""}, {""quote"": ""ThiH is a tyrosine lyase that cleaves the Cα–Cβ bond of tyrosine"", ""reference_id"": ""PMID:19923213""}]"	"[{""id"": ""PMID:19923213"", ""source_sha256"": ""25915620054c357692ee48396ac5dff4888f149b34fa23cf46e1da1df3a474a1"", ""source_version"": ""PMC full article HTML retrieved 2026-10-11; actual HTML digest"", ""title"": ""Catalytic Activity of the Anaerobic Tyrosine Lyase Required for Thiamine Biosynthesis in Escherichia coli*\n"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2820752/""}, {""id"": ""UniProtKB:P30140"", ""source_sha256"": ""873b14d2454f2ab3bd4a0af773fe8b4606904e335d09bf65ca0cea9f31c6d036"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 174; actual body digest"", ""title"": ""2-iminoacetate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30140.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-077_28274304c778	MetaCyc:CPLX0-3949	pathwaymech:catalyzes	RHEA:26298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:17403671|UniProtKB:P30139	ThiG performs the thiazole-forming reaction in the ThiGH system with ThiS thiocarboxylate. Exact tautomer stereochemistry follows current Rhea/UniProt; the 2009 product-structure experiment used B. subtilis and is not described as an E. coli-specific structural measurement.	"[{""reference_id"": ""UniProtKB:P30139"", ""source_assertion"": ""ThiG is annotated with RHEA:26297, consuming ThiS thiocarboxylate, dehydroglycine and DXP and producing the (2R,5Z) thiazole tautomer; this reaction comment has no attached ECO code."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY']""}, {""quote"": ""The activity is shown to require four proteins isolated as heterodimers: ThiGH and ThiFS."", ""reference_id"": ""PMID:17403671""}]"	"[{""id"": ""PMID:17403671"", ""source_sha256"": ""966bb9c9b2b88691c59868c8efe42ae0544a3b286ab80296a36c0400fd3dc103"", ""source_version"": ""Europe PMC indexed primary abstract and metadata retrieved 2026-10-11; not a full-text digest"", ""title"": ""Thiazole synthase from Escherichia coli: an investigation of the substrates and purified proteins required for activity in vitro."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17403671%20AND%20SRC:MED&format=xml&resultType=core""}, {""id"": ""UniProtKB:P30139"", ""source_sha256"": ""00c096f44e433cd321cb938ea608ea6cdf615a0399e2965ca8ab27f838987c7c"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 185; actual body digest"", ""title"": ""Thiazole synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30139.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-078_db390976f41b	UniProtKB:P30136	pathwaymech:enables	RHEA:24841	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:15326535|UniProtKB:P30136	ThiC supplies HMP-P. The E. coli protein annotation transfers the detailed radical-SAM chemistry from family evidence; direct E. coli cell-free reconstitution required an additional unidentified protein. Later purified structural and mechanistic studies used other bacterial ThiC proteins. Homodimer and cluster annotations are explicitly inferred.	"[{""reference_id"": ""UniProtKB:P30136"", ""source_assertion"": ""ThiC is assigned RHEA:24840 by ECO:0000255, HAMAP-Rule MF_00089."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY']""}, {""quote"": ""The E. coli thiC gene product and an additional unidentified E. coli protein are required for the reaction."", ""reference_id"": ""PMID:15326535""}, {""reference_id"": ""UniProtKB:P30136"", ""source_assertion"": ""ThiC is a homodimer by ECO:0000255, HAMAP-Rule MF_00089."", ""source_locator"": ""comments[commentType='SUBUNIT']""}]"	"[{""id"": ""PMID:15326535"", ""source_sha256"": ""3e9920ec4c149fdfd919016c5b0039e6d655572a57fdc1a0565a6adadb142b5c"", ""source_version"": ""Europe PMC indexed primary abstract and metadata retrieved 2026-10-11; not a full-text digest"", ""title"": ""Biosynthesis of the thiamin pyrimidine: the reconstitution of a remarkable rearrangement reaction."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15326535%20AND%20SRC:MED&format=xml&resultType=core""}, {""id"": ""UniProtKB:P30136"", ""source_sha256"": ""657c6c480fa7e9086c3fa986b849f3a14981efca8fa77cd35af86e4fdb8f482e"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 175; actual body digest"", ""title"": ""Phosphomethylpyrimidine synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30136.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-079_c56b425753b9	UniProtKB:P76422	pathwaymech:enables	RHEA:19894	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:HMP-P-KIN-CPLX|UniProtKB:P76422	ThiD phosphorylates HMP-P. Current UniProt annotates a monomer from PMID10075431; the older native HMP-P-KIN-CPLX specifies a tetramer from a different study. The functional edge does not resolve that unresolved oligomer discrepancy. HMP salvage kinase activity is outside this de novo route.	"[{""reference_id"": ""UniProtKB:P76422"", ""source_assertion"": ""ThiD catalyzes RHEA:19893 HMP-P phosphorylation; ECO:0000269, PMID10075431."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY']""}, {""reference_id"": ""UniProtKB:P76422"", ""source_assertion"": ""ThiD is annotated as a monomer with ECO:0000269, PMID10075431."", ""source_locator"": ""comments[commentType='SUBUNIT']""}, {""reference_id"": ""MetaCyc:HMP-P-KIN-CPLX"", ""source_assertion"": ""The older native assembly contains four HMP-P-KIN-MONOMER subunits, citing Reddick et al. 1998; this differs from the current monomer annotation."", ""source_locator"": ""Protein/component/coefficient; component/citation""}]"	"[{""id"": ""MetaCyc:HMP-P-KIN-CPLX"", ""source_sha256"": ""27063f190186c32c8ac468611da35424dcafe7d4843efd44a23fcd633e997640"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""HMP-P-KIN-CPLX"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:HMP-P-KIN-CPLX""}, {""id"": ""UniProtKB:P76422"", ""source_sha256"": ""b0dfa0d060f67fe121e20c2823b469bc94dde145a6132a1706ff391d112f0577"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 164; actual body digest"", ""title"": ""Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P76422.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-080_47da4c4e0544	UniProtKB:P30137	pathwaymech:catalyzes	RHEA:47845	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN-12611|UniProtKB:P30137	ThiE couples the native nonaromatic carboxythiazole tautomer with HMP-PP, releasing CO2 and PPi. The structured annotation selects this substrate; detailed tautomer work on B. subtilis is supporting cross-species context, not proof of an identical measured E. coli substrate preference.	"[{""reference_id"": ""UniProtKB:P30137"", ""source_assertion"": ""ThiE is annotated with RHEA:47844 for the (2R,5Z) tautomer. ECO:0000269 points to reference5, the 1995 Backstrom et al. JACS paper; the later tautomer-specific experiment is not that citation."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY']""}, {""reference_id"": ""MetaCyc:RXN-12611"", ""source_assertion"": ""ENZRXN-19942 assigns the tautomer-dependent condensation RXN-12611 to THIE-MONOMER."", ""source_locator"": ""Reaction/enzymatic-reaction/Enzymatic-Reaction[@frameid=\""ENZRXN-19942\""]/enzyme""}]"	"[{""id"": ""MetaCyc:RXN-12611"", ""source_sha256"": ""eeed5dd2b07d0e7d4c0f42db888b8e49f2629f0e7b03ab89e72409e6024415e7"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""thiamin phosphate synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN-12611""}, {""id"": ""UniProtKB:P30137"", ""source_sha256"": ""527c5b8c50ca84d497a52867438a862be552b769c2a5b0906cfd5b0ff225d4c8"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 187; actual body digest"", ""title"": ""Thiamine-phosphate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30137.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-081_8a731b2ff755	UniProtKB:P0AGG0	pathwaymech:catalyzes	RHEA:15914	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:6284709|UniProtKB:P0AGG0	ThiL phosphorylates TMP to thiamine diphosphate. No metal-independent claim follows from the absence of a UniProt cofactor comment; neither thiamine salvage phosphorylation nor phosphatase routes are added.	"[{""reference_id"": ""UniProtKB:P0AGG0"", ""source_assertion"": ""ThiL catalyzes RHEA:15913; ECO:0000269, PMID4567662."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY']""}, {""quote"": ""the latter lacks thiamine monophosphate kinase activity"", ""reference_id"": ""PMID:6284709""}]"	"[{""id"": ""PMID:6284709"", ""source_sha256"": ""a05512b7aa902a6f13d3ad28beb0aa7e2c85287c5d9ffdd5b9ef306804d2960d"", ""source_version"": ""Europe PMC indexed primary abstract and metadata retrieved 2026-10-11; not a full-text digest"", ""title"": ""thiK and thiL loci of Escherichia coli."", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6284709%20AND%20SRC:MED&format=xml&resultType=core""}, {""id"": ""UniProtKB:P0AGG0"", ""source_sha256"": ""5272c2e747dabd317ede8c4ab32ff17aee3f74204fd4d4ab30c3a7655675f68d"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 134; actual body digest"", ""title"": ""Thiamine-monophosphate kinase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AGG0.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-082_40d999a3c7eb	UniProtKB:P0A6B7	BFO:0000050	MetaCyc:CPLX0-248	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-248|MetaCyc:G7325-MONOMER|UniProtKB:P0A6B7	Native stoichiometry: 2 subunits. The reviewed protein SUBUNIT annotation independently supports the homodimer.	"[{""reference_id"": ""MetaCyc:CPLX0-248"", ""source_assertion"": ""CPLX0-248 contains its mapped P0A6B7 gene product with native component coefficient 2."", ""source_locator"": ""Protein/component/Protein and coefficient""}, {""reference_id"": ""UniProtKB:P0A6B7"", ""source_assertion"": ""Homodimer; supported by the reviewed direct-experiment SUBUNIT annotation."", ""source_locator"": ""comments[commentType='SUBUNIT']""}, {""reference_id"": ""MetaCyc:G7325-MONOMER"", ""source_assertion"": ""G7325-MONOMER has UniProt cross-reference P0A6B7."", ""source_locator"": ""Protein/dblink[dblink-db='UNIPROT']/dblink-oid""}]"	"[{""id"": ""MetaCyc:CPLX0-248"", ""source_sha256"": ""e8ae4d9a6ee046d433c646e83b317624ea3f4467b5e58f0c844a242129aacf6e"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""cysteine desulfurase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-248""}, {""id"": ""MetaCyc:G7325-MONOMER"", ""source_sha256"": ""557d0dc9060ac3d794d97c59d4b91b5cad3845874d9e77f28f714ef87a6266d1"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""cysteine desulfurase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:G7325-MONOMER""}, {""id"": ""UniProtKB:P0A6B7"", ""source_sha256"": ""a0d3b03558f20344c51483645cc0686eec98b255dcfe98c218bbb32d698ebc62"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 162; actual body digest"", ""title"": ""Cysteine desulfurase IscS"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6B7.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-083_e3871c2d31c2	UniProtKB:P77488	BFO:0000050	MetaCyc:CPLX0-743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-743|MetaCyc:DXS-MONOMER|UniProtKB:P77488	Native stoichiometry: 2 subunits. The reviewed protein SUBUNIT annotation independently supports the homodimer.	"[{""reference_id"": ""MetaCyc:CPLX0-743"", ""source_assertion"": ""CPLX0-743 contains its mapped P77488 gene product with native component coefficient 2."", ""source_locator"": ""Protein/component/Protein and coefficient""}, {""reference_id"": ""UniProtKB:P77488"", ""source_assertion"": ""Homodimer; supported by the reviewed direct-experiment SUBUNIT annotation."", ""source_locator"": ""comments[commentType='SUBUNIT']""}, {""reference_id"": ""MetaCyc:DXS-MONOMER"", ""source_assertion"": ""DXS-MONOMER has UniProt cross-reference P77488."", ""source_locator"": ""Protein/dblink[dblink-db='UNIPROT']/dblink-oid""}]"	"[{""id"": ""MetaCyc:CPLX0-743"", ""source_sha256"": ""1fe397e0ef222e57a2c252c3cdc15dcbf53fbd57b0cda1ef8ecde190eb69eb8b"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""CPLX0-743"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-743""}, {""id"": ""MetaCyc:DXS-MONOMER"", ""source_sha256"": ""d0ff9f24c03acdecf69e36b41c6a490de03c0eff0bef48344569905c24003e70"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""1-deoxy-D-xylulose-5-phosphate synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:DXS-MONOMER""}, {""id"": ""UniProtKB:P77488"", ""source_sha256"": ""5628fe96cf93c95aaa5241f0733dd0fdb541ef3d93e92cac805397ba64e5f848"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 199; actual body digest"", ""title"": ""1-deoxy-D-xylulose-5-phosphate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77488.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-084_be1ad123b163	UniProtKB:P30139	BFO:0000050	MetaCyc:CPLX0-3949	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-3949|MetaCyc:THIG-MONOMER|PMID:19923213|UniProtKB:P30139	Native stoichiometry: 6 subunits. The isolated complex comprises at least six ThiGH heterodimers in primary chromatography; this is not a universal cellular stoichiometry claim.	"[{""reference_id"": ""MetaCyc:CPLX0-3949"", ""source_assertion"": ""CPLX0-3949 contains its mapped P30139 gene product with native component coefficient 6."", ""source_locator"": ""Protein/component/Protein and coefficient""}, {""reference_id"": ""UniProtKB:P30139"", ""source_assertion"": ""Forms ThiGH heterodimers; ECO:0000269, PMID12650933. The native larger complex is an assembly of these heterodimeric units."", ""source_locator"": ""comments[commentType='SUBUNIT']""}, {""quote"": ""at least six ThiGH heterodimers"", ""reference_id"": ""PMID:19923213""}, {""reference_id"": ""MetaCyc:THIG-MONOMER"", ""source_assertion"": ""THIG-MONOMER has UniProt cross-reference P30139."", ""source_locator"": ""Protein/dblink[dblink-db='UNIPROT']/dblink-oid""}]"	"[{""id"": ""MetaCyc:CPLX0-3949"", ""source_sha256"": ""062b90f2ed2be258fec5e649c58cf737176d3cbbe6ce8d65b127d96ab5f5aa95"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""thiazole synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-3949""}, {""id"": ""MetaCyc:THIG-MONOMER"", ""source_sha256"": ""e03254efa587b655ff4ac5cbb6ccacb22e2a13b586b44ae65a405a6aa3f2b92c"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:THIG-MONOMER""}, {""id"": ""PMID:19923213"", ""source_sha256"": ""25915620054c357692ee48396ac5dff4888f149b34fa23cf46e1da1df3a474a1"", ""source_version"": ""PMC full article HTML retrieved 2026-10-11; actual HTML digest"", ""title"": ""Catalytic Activity of the Anaerobic Tyrosine Lyase Required for Thiamine Biosynthesis in Escherichia coli*\n"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2820752/""}, {""id"": ""UniProtKB:P30139"", ""source_sha256"": ""00c096f44e433cd321cb938ea608ea6cdf615a0399e2965ca8ab27f838987c7c"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 185; actual body digest"", ""title"": ""Thiazole synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30139.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-085_65467bbe6880	UniProtKB:P30140	BFO:0000050	MetaCyc:CPLX0-3949	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-3949|MetaCyc:THIH-MONOMER|PMID:19923213|UniProtKB:P30140	Native stoichiometry: 6 subunits. The isolated complex comprises at least six ThiGH heterodimers in primary chromatography; this is not a universal cellular stoichiometry claim.	"[{""reference_id"": ""MetaCyc:CPLX0-3949"", ""source_assertion"": ""CPLX0-3949 contains its mapped P30140 gene product with native component coefficient 6."", ""source_locator"": ""Protein/component/Protein and coefficient""}, {""reference_id"": ""UniProtKB:P30140"", ""source_assertion"": ""Forms ThiGH heterodimers; ECO:0000269, PMID12650933. The native larger complex is an assembly of these heterodimeric units."", ""source_locator"": ""comments[commentType='SUBUNIT']""}, {""quote"": ""at least six ThiGH heterodimers"", ""reference_id"": ""PMID:19923213""}, {""reference_id"": ""MetaCyc:THIH-MONOMER"", ""source_assertion"": ""THIH-MONOMER has UniProt cross-reference P30140."", ""source_locator"": ""Protein/dblink[dblink-db='UNIPROT']/dblink-oid""}]"	"[{""id"": ""MetaCyc:CPLX0-3949"", ""source_sha256"": ""062b90f2ed2be258fec5e649c58cf737176d3cbbe6ce8d65b127d96ab5f5aa95"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""thiazole synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-3949""}, {""id"": ""MetaCyc:THIH-MONOMER"", ""source_sha256"": ""eb3afa2b87141702fa9f28c300bb033f72d9fefe7f86ba933f1d93ae1da9a1d9"", ""source_version"": ""MetaCyc 22.5 native XML; retrieved 2026-10-11"", ""title"": ""2-iminoacetate synthase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:THIH-MONOMER""}, {""id"": ""PMID:19923213"", ""source_sha256"": ""25915620054c357692ee48396ac5dff4888f149b34fa23cf46e1da1df3a474a1"", ""source_version"": ""PMC full article HTML retrieved 2026-10-11; actual HTML digest"", ""title"": ""Catalytic Activity of the Anaerobic Tyrosine Lyase Required for Thiamine Biosynthesis in Escherichia coli*\n"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2820752/""}, {""id"": ""UniProtKB:P30140"", ""source_sha256"": ""873b14d2454f2ab3bd4a0af773fe8b4606904e335d09bf65ca0cea9f31c6d036"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 174; actual body digest"", ""title"": ""2-iminoacetate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30140.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-086_e5007bcf1f8d	UniProtKB:P0A6B7	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6B7	PLP; direct-study support includes PMID12860127, with HAMAP evidence also present. The diprotic ChEBI form follows current UniProt.	"[{""reference_id"": ""UniProtKB:P0A6B7"", ""source_assertion"": ""PLP; direct-study support includes PMID12860127, with HAMAP evidence also present. The diprotic ChEBI form follows current UniProt."", ""source_locator"": ""comments[commentType='COFACTOR']""}]"	"[{""id"": ""UniProtKB:P0A6B7"", ""source_sha256"": ""a0d3b03558f20344c51483645cc0686eec98b255dcfe98c218bbb32d698ebc62"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 162; actual body digest"", ""title"": ""Cysteine desulfurase IscS"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6B7.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-087_79086815b552	UniProtKB:P30138	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:16388576|UniProtKB:P30138	One Zn2+ per ThiF subunit; ECO:0000269, PMIDs15896804 and16388576. The primary structure places zinc away from the active site, consistent with a structural role.	"[{""reference_id"": ""UniProtKB:P30138"", ""source_assertion"": ""Binds one Zn2+ per ThiF subunit; ECO:0000269, PMIDs 15896804 and 16388576."", ""source_locator"": ""comments[commentType='COFACTOR']""}, {""reference_id"": ""PMID:16388576"", ""source_assertion"": ""In the E. coli ThiF structure, zinc lies more than 20 Å from the active site; the authors interpret its role as most likely structural rather than catalytic."", ""source_locator"": ""Results, ThiF active site, paragraph P21 (PMC2566941 section S11).""}]"	"[{""id"": ""PMID:16388576"", ""source_sha256"": ""eef53bd9f39e6d70f238f2dda0985e22d7af189785315d1531edebe9cf27d1e1"", ""source_version"": ""PMC full article HTML retrieved 2026-10-11; actual HTML digest"", ""title"": ""Structure of the Escherichia coli ThiS-ThiF complex, a key component of the sulfur transfer system in thiamin biosynthesis"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2566941/""}, {""id"": ""UniProtKB:P30138"", ""source_sha256"": ""5e98839c0742e8f4af9469f8af50f9fd033adc67bb5edf10900ca174023eee89"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 187; actual body digest"", ""title"": ""Sulfur carrier protein ThiS adenylyltransferase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30138.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-088_6adcf20e6614	UniProtKB:P30140	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P30140	One [4Fe-4S] cluster per ThiH subunit; ECO:0000269, PMIDs12650933 and17403671; three cysteine ligands plus exchangeable SAM.	"[{""reference_id"": ""UniProtKB:P30140"", ""source_assertion"": ""One [4Fe-4S] cluster per ThiH subunit; ECO:0000269, PMIDs12650933 and17403671; three cysteine ligands plus exchangeable SAM."", ""source_locator"": ""comments[commentType='COFACTOR']""}]"	"[{""id"": ""UniProtKB:P30140"", ""source_sha256"": ""873b14d2454f2ab3bd4a0af773fe8b4606904e335d09bf65ca0cea9f31c6d036"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 174; actual body digest"", ""title"": ""2-iminoacetate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30140.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-089_b8507a3763a7	UniProtKB:P30136	pathwaymech:has_cofactor	CHEBI:49883	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P30136	One [4Fe-4S] cluster per ThiC subunit; ECO:0000255, HAMAP-Rule MF_00089. This is an inferred E. coli assignment, not an E. coli cluster-structure measurement.	"[{""reference_id"": ""UniProtKB:P30136"", ""source_assertion"": ""One [4Fe-4S] cluster per ThiC subunit; ECO:0000255, HAMAP-Rule MF_00089. This is an inferred E. coli assignment, not an E. coli cluster-structure measurement."", ""source_locator"": ""comments[commentType='COFACTOR']""}]"	"[{""id"": ""UniProtKB:P30136"", ""source_sha256"": ""657c6c480fa7e9086c3fa986b849f3a14981efca8fa77cd35af86e4fdb8f482e"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 175; actual body digest"", ""title"": ""Phosphomethylpyrimidine synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30136.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-090_46aead9f0dc4	UniProtKB:P77488	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77488	One Mg2+ per Dxs subunit; ECO:0000269, PMID17135236.	"[{""reference_id"": ""UniProtKB:P77488"", ""source_assertion"": ""One Mg2+ per Dxs subunit; ECO:0000269, PMID17135236."", ""source_locator"": ""comments[commentType='COFACTOR']""}]"	"[{""id"": ""UniProtKB:P77488"", ""source_sha256"": ""5628fe96cf93c95aaa5241f0733dd0fdb541ef3d93e92cac805397ba64e5f848"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 199; actual body digest"", ""title"": ""1-deoxy-D-xylulose-5-phosphate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77488.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-091_a4463b1bab94	UniProtKB:P77488	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P77488	Thiamine diphosphate is a bound Dxs cofactor; ECO:0000269, PMIDs9371765 and17135236.	"[{""reference_id"": ""UniProtKB:P77488"", ""source_assertion"": ""Thiamine diphosphate is a bound Dxs cofactor; ECO:0000269, PMIDs9371765 and17135236."", ""source_locator"": ""comments[commentType='COFACTOR']""}]"	"[{""id"": ""UniProtKB:P77488"", ""source_sha256"": ""5628fe96cf93c95aaa5241f0733dd0fdb541ef3d93e92cac805397ba64e5f848"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 199; actual body digest"", ""title"": ""1-deoxy-D-xylulose-5-phosphate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P77488.json""}]"	""
pathwaymech:MetaCyc_THISYN-PWY_thiamine-edge-092_2edf2aa628e5	UniProtKB:P30137	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P30137	ThiE binds Mg2+; ECO:0000250 by similarity, not a direct E. coli cofactor experiment.	"[{""reference_id"": ""UniProtKB:P30137"", ""source_assertion"": ""ThiE binds Mg2+; ECO:0000250 by similarity, not a direct E. coli cofactor experiment."", ""source_locator"": ""comments[commentType='COFACTOR']""}]"	"[{""id"": ""UniProtKB:P30137"", ""source_sha256"": ""527c5b8c50ca84d497a52867438a862be552b769c2a5b0906cfd5b0ff225d4c8"", ""source_version"": ""Reviewed full UniProt JSON retrieved 2026-10-11; entry version 187; actual body digest"", ""title"": ""Thiamine-phosphate synthase"", ""url"": ""https://rest.uniprot.org/uniprotkb/P30137.json""}]"	""
pathwaymech:gomodel_YeastPathways_THREOCAT2-PWY_edge-001_b4a84feeec69	gomodel:THREDEHYD2-RXN	RO:0002233	CHEBI:57926	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_THREOCAT2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_THREOCAT2-PWY"", ""source_assertion"": ""The model asserts gomodel:THREDEHYD2-RXN RO:0002233 gomodel:CHEBI_57926_THREDEHYD2-RXN."", ""source_locator"": ""./YeastPathways_THREOCAT2-PWY.json#/facts/7; endpoint types: /individuals/52/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_THREOCAT2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-30; member ./YeastPathways_THREOCAT2-PWY.json"", ""title"": ""GO-CAM threonine degradation model YeastPathways_THREOCAT2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_THREOCAT2-PWY_edge-003_f5ad2fceb508	gomodel:THREDEHYD2-RXN	BFO:0000050	GO:0006567	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_THREOCAT2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_THREOCAT2-PWY"", ""source_assertion"": ""The model asserts gomodel:THREDEHYD2-RXN BFO:0000050 gomodel:YeastPathways_THREOCAT2-PWY/YeastPathways_THREOCAT2-PWY."", ""source_locator"": ""./YeastPathways_THREOCAT2-PWY.json#/facts/18; endpoint types: /individuals/52/type; /individuals/138/type""}]"	"[{""id"": ""gomodel:YeastPathways_THREOCAT2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-30; member ./YeastPathways_THREOCAT2-PWY.json"", ""title"": ""GO-CAM threonine degradation model YeastPathways_THREOCAT2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_THREOCAT2-PWY_edge-008_69535102f41b	gomodel:THREDEHYD2-RXN	RO:0002234	CHEBI:16134	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_THREOCAT2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_THREOCAT2-PWY"", ""source_assertion"": ""The model asserts gomodel:THREDEHYD2-RXN RO:0002234 gomodel:CHEBI_16134_THREDEHYD2-RXN."", ""source_locator"": ""./YeastPathways_THREOCAT2-PWY.json#/facts/42; endpoint types: /individuals/52/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_THREOCAT2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-30; member ./YeastPathways_THREOCAT2-PWY.json"", ""title"": ""GO-CAM threonine degradation model YeastPathways_THREOCAT2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_THREOCAT2-PWY_edge-009_57d7ec9b576f	SGD:S000000569	pathwaymech:enables	gomodel:THREDEHYD2-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_THREOCAT2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_THREOCAT2-PWY"", ""source_assertion"": ""The model asserts gomodel:THREDEHYD2-RXN RO:0002333 gomodel:YCL064C-MONOMER_THREDEHYD2-RXN_controller."", ""source_locator"": ""./YeastPathways_THREOCAT2-PWY.json#/facts/45; endpoint types: /individuals/52/type; /individuals/56/type""}]"	"[{""id"": ""gomodel:YeastPathways_THREOCAT2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-30; member ./YeastPathways_THREOCAT2-PWY.json"", ""title"": ""GO-CAM threonine degradation model YeastPathways_THREOCAT2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_THREOCAT2-PWY_edge-011_37cdb457e205	gomodel:THREDEHYD2-RXN	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_THREOCAT2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_THREOCAT2-PWY"", ""source_assertion"": ""The model asserts gomodel:THREDEHYD2-RXN RO:0002234 gomodel:CHEBI_15377_THREDEHYD2-RXN."", ""source_locator"": ""./YeastPathways_THREOCAT2-PWY.json#/facts/49; endpoint types: /individuals/52/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_THREOCAT2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-30; member ./YeastPathways_THREOCAT2-PWY.json"", ""title"": ""GO-CAM threonine degradation model YeastPathways_THREOCAT2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_THREOCAT2-PWY_edge-012_b7017158bc6e	gomodel:THREDEHYD2-RXN	RO:0002234	CHEBI:16763	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_THREOCAT2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_THREOCAT2-PWY"", ""source_assertion"": ""The model asserts gomodel:THREDEHYD2-RXN RO:0002234 gomodel:CHEBI_16763_THREDEHYD2-RXN."", ""source_locator"": ""./YeastPathways_THREOCAT2-PWY.json#/facts/60; endpoint types: /individuals/52/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_THREOCAT2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-30; member ./YeastPathways_THREOCAT2-PWY.json"", ""title"": ""GO-CAM threonine degradation model YeastPathways_THREOCAT2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_THREOCAT2-PWY_edge-014_ae13e2d1b493	gomodel:THREDEHYD2-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_THREOCAT2-PWY		"[{""reference_id"": ""gomodel:YeastPathways_THREOCAT2-PWY"", ""source_assertion"": ""The model asserts gomodel:THREDEHYD2-RXN RO:0002233 gomodel:CHEBI_15377_THREDEHYD2-RXN."", ""source_locator"": ""./YeastPathways_THREOCAT2-PWY.json#/facts/77; endpoint types: /individuals/52/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_THREOCAT2-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-30; member ./YeastPathways_THREOCAT2-PWY.json"", ""title"": ""GO-CAM threonine degradation model YeastPathways_THREOCAT2-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_THREOCAT2-PWY_edge-017_5e6fb2f50e3b	UniProtKB:P37303	pathwaymech:enables	GO:0004793	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37303		"[{""reference_id"": ""UniProtKB:P37303"", ""source_assertion"": ""Reviewed GLY1 is annotated to threonine aldolase activity and catalyzes L-threonine cleavage to acetaldehyde and glycine; the catalytic annotation cites experimental evidence from PMID:9151955."", ""source_locator"": ""UniProt JSON #/results/0/comments/1/reaction; /results/0/uniProtKBCrossReferences/38""}]"	"[{""id"": ""UniProtKB:P37303"", ""source_sha256"": ""f66256c250243efb72e5b6108db6b8aef1acf264f0e212166aeb12dd6374e748"", ""source_version"": ""Entry 198; annotation update 2026-06-10"", ""title"": ""UniProt reviewed GLY1 (P37303), Saccharomyces cerevisiae S288C"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28gene_exact%3AGLY1%29%20AND%20%28organism_id%3A559292%29%20AND%20%28reviewed%3Atrue%29&format=json""}]"	""
pathwaymech:gomodel_YeastPathways_THREOCAT2-PWY_edge-018_5e51581922ca	GO:0004793	RO:0002233	CHEBI:57926	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37303		"[{""reference_id"": ""UniProtKB:P37303"", ""source_assertion"": ""The reviewed GLY1 catalytic reaction is L-threonine = acetaldehyde + glycine; its ChEBI cross-references identify L-threonine as CHEBI:57926."", ""source_locator"": ""UniProt JSON #/results/0/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P37303"", ""source_sha256"": ""f66256c250243efb72e5b6108db6b8aef1acf264f0e212166aeb12dd6374e748"", ""source_version"": ""Entry 198; annotation update 2026-06-10"", ""title"": ""UniProt reviewed GLY1 (P37303), Saccharomyces cerevisiae S288C"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28gene_exact%3AGLY1%29%20AND%20%28organism_id%3A559292%29%20AND%20%28reviewed%3Atrue%29&format=json""}]"	""
pathwaymech:gomodel_YeastPathways_THREOCAT2-PWY_edge-019_249039ede48f	GO:0004793	RO:0002234	CHEBI:15343	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37303		"[{""reference_id"": ""UniProtKB:P37303"", ""source_assertion"": ""The reviewed GLY1 catalytic reaction produces acetaldehyde, cross-referenced as CHEBI:15343, from L-threonine."", ""source_locator"": ""UniProt JSON #/results/0/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P37303"", ""source_sha256"": ""f66256c250243efb72e5b6108db6b8aef1acf264f0e212166aeb12dd6374e748"", ""source_version"": ""Entry 198; annotation update 2026-06-10"", ""title"": ""UniProt reviewed GLY1 (P37303), Saccharomyces cerevisiae S288C"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28gene_exact%3AGLY1%29%20AND%20%28organism_id%3A559292%29%20AND%20%28reviewed%3Atrue%29&format=json""}]"	""
pathwaymech:gomodel_YeastPathways_THREOCAT2-PWY_edge-020_3bcab43443e2	GO:0004793	RO:0002234	CHEBI:57305	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37303		"[{""reference_id"": ""UniProtKB:P37303"", ""source_assertion"": ""The reviewed GLY1 catalytic reaction produces glycine, cross-referenced as CHEBI:57305, from L-threonine."", ""source_locator"": ""UniProt JSON #/results/0/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P37303"", ""source_sha256"": ""f66256c250243efb72e5b6108db6b8aef1acf264f0e212166aeb12dd6374e748"", ""source_version"": ""Entry 198; annotation update 2026-06-10"", ""title"": ""UniProt reviewed GLY1 (P37303), Saccharomyces cerevisiae S288C"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28gene_exact%3AGLY1%29%20AND%20%28organism_id%3A559292%29%20AND%20%28reviewed%3Atrue%29&format=json""}]"	""
pathwaymech:gomodel_YeastPathways_THREOCAT2-PWY_edge-021_bb9a2f865a18	UniProtKB:P37303	RO:0001025	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37303		"[{""reference_id"": ""UniProtKB:P37303"", ""source_assertion"": ""The reviewed GLY1 entry records a cytosol annotation (GO:0005829) with IDA:SGD evidence."", ""source_locator"": ""UniProt JSON #/results/0/uniProtKBCrossReferences/36""}]"	"[{""id"": ""UniProtKB:P37303"", ""source_sha256"": ""f66256c250243efb72e5b6108db6b8aef1acf264f0e212166aeb12dd6374e748"", ""source_version"": ""Entry 198; annotation update 2026-06-10"", ""title"": ""UniProt reviewed GLY1 (P37303), Saccharomyces cerevisiae S288C"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28gene_exact%3AGLY1%29%20AND%20%28organism_id%3A559292%29%20AND%20%28reviewed%3Atrue%29&format=json""}]"	""
pathwaymech:gomodel_YeastPathways_THREOCAT2-PWY_edge-022_ff0af7074432	GO:0004793	BFO:0000050	GO:0006567	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37303		"[{""reference_id"": ""UniProtKB:P37303"", ""source_assertion"": ""UniProt assigns GLY1 to the single-step L-threonine degradation via the aldolase pathway and records L-threonine catabolic process (GO:0006567)."", ""source_locator"": ""UniProt JSON #/results/0/comments/5; /results/0/uniProtKBCrossReferences/40""}]"	"[{""id"": ""UniProtKB:P37303"", ""source_sha256"": ""f66256c250243efb72e5b6108db6b8aef1acf264f0e212166aeb12dd6374e748"", ""source_version"": ""Entry 198; annotation update 2026-06-10"", ""title"": ""UniProt reviewed GLY1 (P37303), Saccharomyces cerevisiae S288C"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28gene_exact%3AGLY1%29%20AND%20%28organism_id%3A559292%29%20AND%20%28reviewed%3Atrue%29&format=json""}]"	""
pathwaymech:gomodel_YeastPathways_THREOCAT2-PWY_location-e41cef4a1699_337667a0f90a	SGD:S000000569	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P25379	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:16823961)	"[{""reference_id"": ""UniProtKB:P25379"", ""source_assertion"": ""UniProtKB:P25379 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3364/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P25379"", ""source_assertion"": ""UniProtKB:P25379 has the exact SGD cross-reference SGD:S000000569."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3364/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P25379"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P25379 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_THREOCAT2-PWY_cofactor-d4c2864ea012_e716532f3f8c	SGD:S000000569	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P25379	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:P25379"", ""source_assertion"": ""UniProtKB:P25379 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3364/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P25379"", ""source_assertion"": ""UniProtKB:P25379 has the exact SGD cross-reference SGD:S000000569."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3364/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P25379"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P25379 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_THREOCAT2-PWY_cofactor-3b6386b65bf6_13b387a7c669	UniProtKB:P37303	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P37303	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P37303"", ""source_assertion"": ""UniProtKB:P37303 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1258/comments/0/cofactors/0""}]"	"[{""id"": ""UniProtKB:P37303"", ""source_sha256"": ""f66256c250243efb72e5b6108db6b8aef1acf264f0e212166aeb12dd6374e748"", ""source_version"": ""Entry 198; annotation update 2026-06-10"", ""title"": ""UniProt reviewed GLY1 (P37303), Saccharomyces cerevisiae S288C"", ""url"": ""https://rest.uniprot.org/uniprotkb/search?query=%28gene_exact%3AGLY1%29%20AND%20%28organism_id%3A559292%29%20AND%20%28reviewed%3Atrue%29&format=json""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-001_9114352141d8	SGD:S000003703	pathwaymech:enables	gomodel:GPPSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:GPPSYN-RXN RO:0002333 gomodel:YJL167W-MONOMER_GPPSYN-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/0; endpoint types: /individuals/9/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-002_6e23509a0177	gomodel:GPPSYN-RXN	RO:0002233	CHEBI:57623	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:GPPSYN-RXN RO:0002233 gomodel:CHEBI_57623_IPPISOM-RXN."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/1; endpoint types: /individuals/9/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-003_82653650e133	SGD:S000003703	pathwaymech:enables	gomodel:FPPSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:FPPSYN-RXN RO:0002333 gomodel:YJL167W-MONOMER_FPPSYN-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/2; endpoint types: /individuals/8/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-004_fae9b80fa09f	gomodel:FPPSYN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:FPPSYN-RXN BFO:0000066 gomodel:reaction_FPPSYN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/3; endpoint types: /individuals/8/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-005_85f33f27171e	gomodel:FPPSYN-RXN	RO:0002233	CHEBI:58057	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:FPPSYN-RXN RO:0002233 gomodel:CHEBI_58057_GPPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/4; endpoint types: /individuals/8/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-006_8fd2a7d962fe	gomodel:FPPSYN-RXN	BFO:0000050	GO:0045337	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:FPPSYN-RXN BFO:0000050 gomodel:YeastPathways_PWY-5123/YeastPathways_PWY-5123."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/5; endpoint types: /individuals/8/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-007_78620b9f4992	gomodel:IPPISOM-RXN	BFO:0000050	GO:0045337	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:IPPISOM-RXN BFO:0000050 gomodel:YeastPathways_PWY-5123/YeastPathways_PWY-5123."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/6; endpoint types: /individuals/10/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-008_92cda43ddf2a	SGD:S000006038	pathwaymech:enables	gomodel:IPPISOM-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:IPPISOM-RXN RO:0002333 gomodel:YPL117C-MONOMER_IPPISOM-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/7; endpoint types: /individuals/10/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-009_0d833824c57b	gomodel:FPPSYN-RXN	RO:0002233	CHEBI:128769	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:FPPSYN-RXN RO:0002233 gomodel:CHEBI_128769_FPPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/8; endpoint types: /individuals/8/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-010_51629c77c506	gomodel:IPPISOM-RXN	RO:0002413	gomodel:GPPSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:IPPISOM-RXN RO:0002413 gomodel:GPPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/9; endpoint types: /individuals/10/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-011_569cb904bcae	gomodel:GPPSYN-RXN	RO:0002233	CHEBI:128769	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:GPPSYN-RXN RO:0002233 gomodel:CHEBI_128769_GPPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/10; endpoint types: /individuals/9/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-012_b2ead2e55639	gomodel:GPPSYN-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:GPPSYN-RXN RO:0002234 gomodel:CHEBI_29888_GPPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/11; endpoint types: /individuals/9/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-013_b5f9a9fa07e5	gomodel:GPPSYN-RXN	RO:0002234	CHEBI:58057	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:GPPSYN-RXN RO:0002234 gomodel:CHEBI_58057_GPPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/12; endpoint types: /individuals/9/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-014_16b8d1320752	gomodel:IPPISOM-RXN	RO:0002233	CHEBI:128769	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:IPPISOM-RXN RO:0002233 gomodel:CHEBI_128769_IPPISOM-RXN."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/13; endpoint types: /individuals/10/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-015_4b94b6f1fa4f	gomodel:GPPSYN-RXN	BFO:0000050	GO:0045337	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:GPPSYN-RXN BFO:0000050 gomodel:YeastPathways_PWY-5123/YeastPathways_PWY-5123."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/14; endpoint types: /individuals/9/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-016_4be8cf3f92f4	gomodel:FPPSYN-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:FPPSYN-RXN RO:0002234 gomodel:CHEBI_29888_FPPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/15; endpoint types: /individuals/8/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-017_2ebba49b4fe3	gomodel:IPPISOM-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:IPPISOM-RXN BFO:0000066 gomodel:reaction_IPPISOM-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/16; endpoint types: /individuals/10/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-018_379c9605d8a8	gomodel:IPPISOM-RXN	RO:0002234	CHEBI:57623	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:IPPISOM-RXN RO:0002234 gomodel:CHEBI_57623_IPPISOM-RXN."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/17; endpoint types: /individuals/10/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-019_f25c5a6b5bc0	gomodel:GPPSYN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:GPPSYN-RXN BFO:0000066 gomodel:reaction_GPPSYN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/18; endpoint types: /individuals/9/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-020_f3f117b17fb1	gomodel:GPPSYN-RXN	RO:0002413	gomodel:FPPSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:GPPSYN-RXN RO:0002413 gomodel:FPPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/19; endpoint types: /individuals/9/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_edge-021_e8c704e5f339	gomodel:FPPSYN-RXN	RO:0002234	CHEBI:175763	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5123		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5123"", ""source_assertion"": ""The model asserts gomodel:FPPSYN-RXN RO:0002234 gomodel:CHEBI_175763_FPPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-5123.json#/facts/20; endpoint types: /individuals/8/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5123"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5123.json"", ""title"": ""SGD GO-CAM trans, trans-farnesyl diphosphate biosynthesis pathway PWY-5123"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_location-ef91d336c5e1_4c09c18b5781	SGD:S000006038	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15496	Physical protein location from reviewed UniProt. ECO:0000305	"[{""reference_id"": ""UniProtKB:P15496"", ""source_assertion"": ""UniProtKB:P15496 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/417/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P15496"", ""source_assertion"": ""UniProtKB:P15496 has the exact SGD cross-reference SGD:S000006038."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/417/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P15496"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P15496 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_cofactor-73954f3c0fc0_4e0438f91f66	SGD:S000003703	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08524	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q12051) Binds 2 Mg(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:Q12051)	"[{""reference_id"": ""UniProtKB:P08524"", ""source_assertion"": ""UniProtKB:P08524 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/209/comments/0/cofactors/0; /results/209/comments/0/note""}, {""reference_id"": ""UniProtKB:P08524"", ""source_assertion"": ""UniProtKB:P08524 has the exact SGD cross-reference SGD:S000003703."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/209/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P08524"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P08524 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5123_cofactor-7a2ce58769da_23021d2ad5a2	SGD:S000006038	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15496	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q46822) Binds 1 Mg(2+) ion per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:Q46822)	"[{""reference_id"": ""UniProtKB:P15496"", ""source_assertion"": ""UniProtKB:P15496 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/417/comments/0/cofactors/0; /results/417/comments/0/note""}, {""reference_id"": ""UniProtKB:P15496"", ""source_assertion"": ""UniProtKB:P15496 has the exact SGD cross-reference SGD:S000006038."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/417/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P15496"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P15496 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_TRESYN-PWY_edge-001_ac0e06426b49	CHEBI:58885	pathwaymech:consumes	RHEA:18890	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18890		"[{""reference_id"": ""RHEA:18890"", ""source_assertion"": ""Rhea lists CHEBI:58885 on the substrates side of RHEA:18890 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18890']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18890"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right trehalose-6-phosphate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/18890""}]"	""
pathwaymech:MetaCyc_TRESYN-PWY_edge-002_fd16d56e475e	CHEBI:61548	pathwaymech:consumes	RHEA:18890	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18890		"[{""reference_id"": ""RHEA:18890"", ""source_assertion"": ""Rhea lists CHEBI:61548 on the substrates side of RHEA:18890 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18890']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18890"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right trehalose-6-phosphate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/18890""}]"	""
pathwaymech:MetaCyc_TRESYN-PWY_edge-003_ee135dfd1497	RHEA:18890	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18890		"[{""reference_id"": ""RHEA:18890"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:18890 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18890']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18890"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right trehalose-6-phosphate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/18890""}]"	""
pathwaymech:MetaCyc_TRESYN-PWY_edge-004_aeafb1e27594	RHEA:18890	pathwaymech:produces	CHEBI:58223	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18890		"[{""reference_id"": ""RHEA:18890"", ""source_assertion"": ""Rhea lists CHEBI:58223 on the products side of RHEA:18890 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18890']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18890"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right trehalose-6-phosphate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/18890""}]"	""
pathwaymech:MetaCyc_TRESYN-PWY_edge-005_7930bcd382f6	RHEA:18890	pathwaymech:produces	CHEBI:58429	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18890		"[{""reference_id"": ""RHEA:18890"", ""source_assertion"": ""Rhea lists CHEBI:58429 on the products side of RHEA:18890 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18890']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18890"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right trehalose-6-phosphate synthase direction"", ""url"": ""https://www.rhea-db.org/rhea/18890""}]"	""
pathwaymech:MetaCyc_TRESYN-PWY_edge-006_2801ea0a0ebd	CHEBI:15377	pathwaymech:consumes	RHEA:23421	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23421		"[{""reference_id"": ""RHEA:23421"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:23421 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23421']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23421"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right trehalose-6-phosphate phosphatase direction"", ""url"": ""https://www.rhea-db.org/rhea/23421""}]"	""
pathwaymech:MetaCyc_TRESYN-PWY_edge-007_1010a82d965c	CHEBI:58429	pathwaymech:consumes	RHEA:23421	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23421		"[{""reference_id"": ""RHEA:23421"", ""source_assertion"": ""Rhea lists CHEBI:58429 on the substrates side of RHEA:23421 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23421']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23421"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right trehalose-6-phosphate phosphatase direction"", ""url"": ""https://www.rhea-db.org/rhea/23421""}]"	""
pathwaymech:MetaCyc_TRESYN-PWY_edge-008_be0e421d15b2	RHEA:23421	pathwaymech:produces	CHEBI:16551	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23421		"[{""reference_id"": ""RHEA:23421"", ""source_assertion"": ""Rhea lists CHEBI:16551 on the products side of RHEA:23421 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23421']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23421"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right trehalose-6-phosphate phosphatase direction"", ""url"": ""https://www.rhea-db.org/rhea/23421""}]"	""
pathwaymech:MetaCyc_TRESYN-PWY_edge-009_656db6091848	RHEA:23421	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:23421		"[{""reference_id"": ""RHEA:23421"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:23421 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/23421']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:23421"", ""source_version"": ""139"", ""title"": ""Rhea left-to-right trehalose-6-phosphate phosphatase direction"", ""url"": ""https://www.rhea-db.org/rhea/23421""}]"	""
pathwaymech:MetaCyc_TRESYN-PWY_edge-010_d01a7b81c03e	EC:2.4.1.15	pathwaymech:catalyzes	RHEA:18890	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:8045430|RHEA:18889		"[{""reference_id"": ""RHEA:18889"", ""source_assertion"": ""Rhea associates EC:2.4.1.15 with the reaction family containing RHEA:18890."", ""source_locator"": ""rh:ec""}, {""quote"": ""The Escherichia coli otsBA operon, located at min 42, was sequenced and shown to encode a 29.1-kDa trehalose-6-phosphate phosphatase (OtsB) and a 53.6-kDa trehalose-6-phosphate synthase (OtsA)."", ""reference_id"": ""PMID:8045430"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Kaasen et al., Gene, 1994"", ""id"": ""PMID:8045430"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/8045430/""}, {""id"": ""RHEA:18889"", ""source_version"": ""139"", ""title"": ""Rhea trehalose-6-phosphate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/18889""}]"	""
pathwaymech:MetaCyc_TRESYN-PWY_edge-011_89ad857021e7	EC:3.1.3.12	pathwaymech:catalyzes	RHEA:23421	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:8045430|RHEA:23420		"[{""reference_id"": ""RHEA:23420"", ""source_assertion"": ""Rhea associates EC:3.1.3.12 with the reaction family containing RHEA:23421."", ""source_locator"": ""rh:ec""}, {""quote"": ""The Escherichia coli otsBA operon, located at min 42, was sequenced and shown to encode a 29.1-kDa trehalose-6-phosphate phosphatase (OtsB) and a 53.6-kDa trehalose-6-phosphate synthase (OtsA)."", ""reference_id"": ""PMID:8045430"", ""source_locator"": ""PubMed Abstract""}]"	"[{""citation"": ""Kaasen et al., Gene, 1994"", ""id"": ""PMID:8045430"", ""url"": ""https://pubmed.ncbi.nlm.nih.gov/8045430/""}, {""id"": ""RHEA:23420"", ""source_version"": ""139"", ""title"": ""Rhea trehalose-6-phosphate phosphatase reaction"", ""url"": ""https://www.rhea-db.org/rhea/23420""}]"	""
pathwaymech:MetaCyc_TRESYN-PWY_edge-012_a27dbed47ad9	RHEA:18890	pathwaymech:precedes	RHEA:23421	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:TRESYN-PWY		"[{""reference_id"": ""MetaCyc:TRESYN-PWY"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:18890 before RHEA:23421 in this pathway. Shared intermediate: CHEBI:58429."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:TRESYN-PWY"", ""source_sha256"": ""51976a56909a8c2f56a90e49270d7a938ad384c1594d5db00481fa38df5839f9"", ""source_version"": ""22.5"", ""title"": ""MetaCyc trehalose biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:TRESYN-PWY&detail=full""}]"	""
pathwaymech:MetaCyc_TRESYN-PWY_edge-013_6bbc5e4dc8ec	UniProtKB:P31677	pathwaymech:enables	RHEA:18890	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31677		"[{""reference_id"": ""UniProtKB:P31677"", ""source_assertion"": ""UniProt annotates UniProtKB:P31677 with catalytic activity for the reaction family of RHEA:18890. Annotation evidence: ECO:0000305; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P31677"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P31677 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31677.json""}]"	""
pathwaymech:MetaCyc_TRESYN-PWY_edge-014_bb5ac4877724	UniProtKB:P31678	pathwaymech:enables	RHEA:23421	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31678		"[{""reference_id"": ""UniProtKB:P31678"", ""source_assertion"": ""UniProt annotates UniProtKB:P31678 with catalytic activity for the reaction family of RHEA:23421. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P31678"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P31678 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31678.json""}]"	""
pathwaymech:MetaCyc_TRESYN-PWY_edge-015_4604f173e669	UniProtKB:P31678	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31678		"[{""reference_id"": ""UniProtKB:P31678"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P31678 (evidence: ECO:0000269). Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P31678"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P31678 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31678.json""}]"	""
pathwaymech:MetaCyc_TRESYN-PWY_edge-016_a1aad74ca8a8	UniProtKB:P31678	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31678		"[{""reference_id"": ""UniProtKB:P31678"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P31678 (evidence: ECO:0000269). Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P31678"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P31678 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31678.json""}]"	""
pathwaymech:MetaCyc_TRESYN-PWY_edge-017_cb622dad411c	UniProtKB:P31678	pathwaymech:has_cofactor	CHEBI:48828	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31678		"[{""reference_id"": ""UniProtKB:P31678"", ""source_assertion"": ""UniProt lists CHEBI:48828 as a cofactor of UniProtKB:P31678 (evidence: ECO:0000269). Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P31678"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P31678 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31678.json""}]"	""
pathwaymech:MetaCyc_TRESYN-PWY_edge-018_43230a945aa7	UniProtKB:P31678	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P31678		"[{""reference_id"": ""UniProtKB:P31678"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P31678 (evidence: ECO:0000269). Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P31678"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P31678 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P31678.json""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-1_229966869b1b	CHEBI:17815	pathwaymech:consumes	WikiPathways:WP266/id1cd7ea26	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML id1cd7ea26 connects normalized CHEBI:17815 as an input of interaction id1cd7ea26."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id1cd7ea26']/Graphics; /Pathway/DataNode[@GraphId='dce5f']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-2_93f0640707c6	WikiPathways:WP266/id1cd7ea26	pathwaymech:produces	CHEBI:64615	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML id1cd7ea26 connects normalized CHEBI:64615 as an output of interaction id1cd7ea26."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id1cd7ea26']/Graphics; /Pathway/DataNode[@GraphId='cf64d']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-3_e8a4ef89cb35	CHEBI:17815	pathwaymech:consumes	WikiPathways:WP266/id3bcd2f4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML id3bcd2f4 connects normalized CHEBI:17815 as an input of interaction id3bcd2f4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id3bcd2f4']/Graphics; /Pathway/DataNode[@GraphId='dce5f']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-4_b1a284d6345e	WikiPathways:WP266/id3bcd2f4	pathwaymech:produces	CHEBI:64615	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML id3bcd2f4 connects normalized CHEBI:64615 as an output of interaction id3bcd2f4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id3bcd2f4']/Graphics; /Pathway/DataNode[@GraphId='cf64d']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-5_364faa139cb0	CHEBI:29089	pathwaymech:consumes	WikiPathways:WP266/id60909eec	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML id60909eec connects normalized CHEBI:29089 as an input of interaction id60909eec."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id60909eec']/Graphics; /Pathway/DataNode[@GraphId='b2af1']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-6_4afc5ff88f02	WikiPathways:WP266/id60909eec	pathwaymech:produces	CHEBI:17815	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML id60909eec connects normalized CHEBI:17815 as an output of interaction id60909eec."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id60909eec']/Graphics; /Pathway/DataNode[@GraphId='dce5f']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-7_e552c980a449	CHEBI:16975	pathwaymech:consumes	WikiPathways:WP266/id85e34cbe	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML id85e34cbe connects normalized CHEBI:16975 as an input of interaction id85e34cbe."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id85e34cbe']/Graphics; /Pathway/DataNode[@GraphId='f64b0']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-8_2e6de70f38dc	WikiPathways:WP266/id85e34cbe	pathwaymech:produces	CHEBI:29089	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML id85e34cbe connects normalized CHEBI:29089 as an output of interaction id85e34cbe."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id85e34cbe']/Graphics; /Pathway/DataNode[@GraphId='b2af1']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-9_cb4a8a1991eb	CHEBI:57597	pathwaymech:consumes	WikiPathways:WP266/idc8402cc8	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML idc8402cc8 connects normalized CHEBI:57597 as an input of interaction idc8402cc8."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idc8402cc8']/Graphics; /Pathway/DataNode[@GraphId='fe042']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-10_188a6d91722f	WikiPathways:WP266/idc8402cc8	pathwaymech:produces	CHEBI:16975	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML idc8402cc8 connects normalized CHEBI:16975 as an output of interaction idc8402cc8."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idc8402cc8']/Graphics; /Pathway/DataNode[@GraphId='f64b0']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-11_f79d50fac218	SGD:S000002210	pathwaymech:catalyzes	WikiPathways:WP266/id85e34cbe	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML id44d2daef connects normalized SGD:S000002210 as a catalyst of interaction id85e34cbe."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id44d2daef']/Graphics; /Pathway/DataNode[@GraphId='a87']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-12_a2849ed4adea	CHEBI:16110	pathwaymech:consumes	WikiPathways:WP266/id1cd7ea26	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML id5db6d8ca connects normalized CHEBI:16110 as an input of interaction id1cd7ea26."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5db6d8ca']/Graphics; /Pathway/DataNode[@GraphId='fc4d6']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-13_0f76db713422	WikiPathways:WP266/id60909eec	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML id8d4f483b connects normalized CHEBI:43474 as an output of interaction id60909eec."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id8d4f483b']/Graphics; /Pathway/DataNode[@GraphId='c3644']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-14_e0e9bdf036c6	SGD:S000000107	pathwaymech:catalyzes	WikiPathways:WP266/idc8402cc8	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML id910aff3b connects normalized SGD:S000000107 as a catalyst of interaction idc8402cc8."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id910aff3b']/Graphics; /Pathway/DataNode[@GraphId='cb880']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-15_84d4a247a9eb	SGD:S000001775	pathwaymech:catalyzes	WikiPathways:WP266/idc8402cc8	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML id910aff3b connects normalized SGD:S000001775 as a catalyst of interaction idc8402cc8."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id910aff3b']/Graphics; /Pathway/DataNode[@GraphId='afdf5']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-16_57eda930577c	SGD:S000005771	pathwaymech:catalyzes	WikiPathways:WP266/id3bcd2f4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML id9a72ee72 connects normalized SGD:S000005771 as a catalyst of interaction id3bcd2f4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id9a72ee72']/Graphics; /Pathway/DataNode[@GraphId='aef']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-17_7c770b7c95a0	WikiPathways:WP266/id85e34cbe	pathwaymech:produces	CHEBI:15346	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML idb9c5729 connects normalized CHEBI:15346 as an output of interaction id85e34cbe."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idb9c5729']/Graphics; /Pathway/DataNode[@GraphId='af189']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-18_516930bc1372	CHEBI:17984	pathwaymech:consumes	WikiPathways:WP266/idc8402cc8	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML idc9355581 connects normalized CHEBI:17984 as an input of interaction idc8402cc8."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idc9355581']/Graphics; /Pathway/DataNode[@GraphId='df041']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-19_0607930f67cf	CHEBI:17984	pathwaymech:consumes	WikiPathways:WP266/id3bcd2f4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML idd980ea96 connects normalized CHEBI:17984 as an input of interaction id3bcd2f4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idd980ea96']/Graphics; /Pathway/DataNode[@GraphId='c78a3']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-20_b3a8dc039aa9	CHEBI:17984	pathwaymech:consumes	WikiPathways:WP266/id85e34cbe	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML ide84619a9 connects normalized CHEBI:17984 as an input of interaction id85e34cbe."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ide84619a9']/Graphics; /Pathway/DataNode[@GraphId='aacf4']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-21_75869df73fc9	CHEBI:15377	pathwaymech:consumes	WikiPathways:WP266/id60909eec	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML idecb8710a connects normalized CHEBI:15377 as an input of interaction id60909eec."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idecb8710a']/Graphics; /Pathway/DataNode[@GraphId='f8051']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-22_3d70eb903116	SGD:S000005291	pathwaymech:catalyzes	WikiPathways:WP266/id1cd7ea26	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML idf55f4b1c connects normalized SGD:S000005291 as a catalyst of interaction id1cd7ea26."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idf55f4b1c']/Graphics; /Pathway/DataNode[@GraphId='c9ac1']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-23_b4360b341a26	WikiPathways:WP266/id1cd7ea26	pathwaymech:produces	CHEBI:17504	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML idf876cb69 connects normalized CHEBI:17504 as an output of interaction id1cd7ea26."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idf876cb69']/Graphics; /Pathway/DataNode[@GraphId='d97ed']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-24_f6a9b98ca59e	SGD:S000004775	pathwaymech:catalyzes	WikiPathways:WP266/id60909eec	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML idf9c930cc connects normalized SGD:S000004775 as a catalyst of interaction id60909eec."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idf9c930cc']/Graphics; /Pathway/DataNode[@GraphId='cf077']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-25_9a16b2ccd667	SGD:S000002692	pathwaymech:catalyzes	WikiPathways:WP266/id60909eec	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML idf9c930cc connects normalized SGD:S000002692 as a catalyst of interaction id60909eec."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idf9c930cc']/Graphics; /Pathway/DataNode[@GraphId='f5e7a']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-26_74f9d64adf4a	SGD:S000002911	pathwaymech:catalyzes	WikiPathways:WP266/id60909eec	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML idf9c930cc connects normalized SGD:S000002911 as a catalyst of interaction id60909eec."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idf9c930cc']/Graphics; /Pathway/DataNode[@GraphId='b48ef']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-27_ac4f9b0022ef	WikiPathways:WP266/idc8402cc8	pathwaymech:produces	CHEBI:15346	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML e60b8 connects normalized CHEBI:15346 as an output of interaction idc8402cc8."", ""source_locator"": ""/Pathway/Interaction[@GraphId='e60b8']/Graphics; /Pathway/DataNode[@GraphId='b1ab6']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_causal-review-28_bff35e910567	WikiPathways:WP266/id3bcd2f4	pathwaymech:produces	CHEBI:15346	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP266		"[{""reference_id"": ""WikiPathways:WP266"", ""source_assertion"": ""GPML e6580 connects normalized CHEBI:15346 as an output of interaction id3bcd2f4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='e6580']/Graphics; /Pathway/DataNode[@GraphId='aa880']""}]"	"[{""id"": ""WikiPathways:WP266"", ""source_sha256"": ""e12ea49dd36ab1039c29e3e919ee5286a4197ee42e68530001eeb116e3d43122"", ""source_version"": ""WP266_r139569"", ""title"": ""WP266 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP266/WP266.gpml""}]"	""
pathwaymech:WikiPathways_WP266_cofactor-7872ce4e5d78_be4ccf0db2a4	SGD:S000004775	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32567	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:16467296)	"[{""reference_id"": ""UniProtKB:P32567"", ""source_assertion"": ""UniProtKB:P32567 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/949/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P32567"", ""source_assertion"": ""UniProtKB:P32567 has the exact SGD cross-reference SGD:S000004775."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/949/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32567"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P32567 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-001_99e540f01cb4	gomodel:YeastPathways_PWY3O-214/65692e7e00000708	RO:0002233	CHEBI:18086	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000708 RO:0002233 gomodel:CHEBI_18086_4.1.1.74-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/0; endpoint types: /individuals/129/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-002_b52e1c6ab765	gomodel:4.1.1.74-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:4.1.1.74-RXN RO:0002234 gomodel:CHEBI_16526_4.1.1.74-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/1; endpoint types: /individuals/43/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-003_22c42af79a03	gomodel:1.1.1.190-RXN	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:1.1.1.190-RXN RO:0002233 gomodel:CHEBI_57945_1.1.1.190-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/2; endpoint types: /individuals/41/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-004_34fadb9c47b9	gomodel:YeastPathways_PWY3O-214/65692e7e00000633	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000633 BFO:0000066 gomodel:YeastPathways_PWY3O-214/65692e7e00000637."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/3; endpoint types: /individuals/61/type; /individuals/64/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-005_6afb63909c26	gomodel:YeastPathways_PWY3O-214/65692e7e00000708	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000708 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000709."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/4; endpoint types: /individuals/129/type; /individuals/130/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-006_c7cecaf78847	gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN	BFO:0000050	GO:0006569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/5; endpoint types: /individuals/13/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-007_3074a69b6e77	SGD:S000004688	pathwaymech:enables	gomodel:1.1.1.190-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:1.1.1.190-RXN RO:0002333 gomodel:YMR083W-MONOMER_1.1.1.190-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/6; endpoint types: /individuals/41/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-008_0567ff9e7b1f	gomodel:YeastPathways_PWY3O-214/65692e7e00000660	RO:0002234	CHEBI:17890	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000660 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000664."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/7; endpoint types: /individuals/87/type; /individuals/91/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-009_70620b5776f3	gomodel:YeastPathways_PWY3O-214/65692e7e00000660	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000660 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000663."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/8; endpoint types: /individuals/87/type; /individuals/90/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-010_c26acc7e7228	gomodel:2.6.1.28-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:2.6.1.28-RXN BFO:0000066 gomodel:reaction_2.6.1.28-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/9; endpoint types: /individuals/42/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-011_9681e44200be	gomodel:YeastPathways_PWY3O-214/65692e7e00000669	RO:0002233	CHEBI:18086	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000669 RO:0002233 gomodel:CHEBI_18086_4.1.1.74-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/10; endpoint types: /individuals/94/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-012_af5f543025b2	SGD:S000003225	pathwaymech:enables	gomodel:YeastPathways_PWY3O-214/65692e7e00000694	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000694 RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000717."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/11; endpoint types: /individuals/117/type; /individuals/137/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-013_cdef6b7dc6f6	gomodel:YeastPathways_PWY3O-214/65692e7e00000708	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000708 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000712."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/12; endpoint types: /individuals/129/type; /individuals/133/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-014_15b5a29d96bb	gomodel:4.1.1.74-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:4.1.1.74-RXN BFO:0000066 gomodel:reaction_4.1.1.74-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/13; endpoint types: /individuals/43/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-015_5749513bdd9b	gomodel:YeastPathways_PWY3O-214/65692e7e00000694	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000694 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000695."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/14; endpoint types: /individuals/117/type; /individuals/118/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-016_fb2c804f4901	gomodel:4.1.1.74-RXN	RO:0002234	CHEBI:18086	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:4.1.1.74-RXN RO:0002234 gomodel:CHEBI_18086_4.1.1.74-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/15; endpoint types: /individuals/43/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-017_aac70f9c17fb	SGD:S000004918	pathwaymech:enables	gomodel:YeastPathways_PWY3O-214/65692e7e00000660	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000660 RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000666."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/16; endpoint types: /individuals/87/type; /individuals/92/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-018_5c6f7d163e9d	gomodel:2.6.1.28-RXN	BFO:0000050	GO:0006569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:2.6.1.28-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/17; endpoint types: /individuals/42/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-019_f042bd821b58	gomodel:YeastPathways_PWY3O-214/65692e7e00000621	BFO:0000050	GO:0006569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000621 BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/18; endpoint types: /individuals/51/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-020_e01fdb22a536	gomodel:YeastPathways_PWY3O-214/65692e7e00000627	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000627 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000629."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/19; endpoint types: /individuals/56/type; /individuals/58/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-021_4ab57680e83b	gomodel:YeastPathways_PWY3O-214/65692e7e00000701	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000701 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000703."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/20; endpoint types: /individuals/123/type; /individuals/125/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-023_dd3577e041e1	gomodel:1.1.1.190-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:1.1.1.190-RXN RO:0002233 gomodel:CHEBI_15378_1.1.1.190-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/22; endpoint types: /individuals/41/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-024_269daf432e8c	gomodel:1.1.1.190-RXN	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:1.1.1.190-RXN RO:0002234 gomodel:CHEBI_57540_1.1.1.190-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/23; endpoint types: /individuals/41/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-025_6b999fa8284e	gomodel:YeastPathways_PWY3O-214/65692e7e00000621	RO:0002234	CHEBI:18086	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000621 RO:0002234 gomodel:CHEBI_18086_4.1.1.74-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/24; endpoint types: /individuals/51/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-026_4b2f4338ea4e	gomodel:YeastPathways_PWY3O-214/65692e7e00000694	RO:0002234	CHEBI:17890	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000694 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000698."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/25; endpoint types: /individuals/117/type; /individuals/121/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-027_050a4fb3666f	gomodel:YeastPathways_PWY3O-214/65692e7e00000621	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000621 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000623."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/26; endpoint types: /individuals/51/type; /individuals/53/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-028_933b94a21f50	gomodel:YeastPathways_PWY3O-214/65692e7e00000701	BFO:0000050	GO:0006569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000701 BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/27; endpoint types: /individuals/123/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-029_8d0ca43ab8d8	gomodel:YeastPathways_PWY3O-214/65692e7e00000694	RO:0002233	CHEBI:18086	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000694 RO:0002233 gomodel:CHEBI_18086_4.1.1.74-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/28; endpoint types: /individuals/117/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-030_547729e5eb88	gomodel:1.1.1.190-RXN	BFO:0000050	GO:0006569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:1.1.1.190-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/29; endpoint types: /individuals/41/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-031_d951525c865e	gomodel:YeastPathways_PWY3O-214/65692e7e00000627	BFO:0000050	GO:0006569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000627 BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/30; endpoint types: /individuals/56/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-032_cff86b75f06f	gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN	RO:0002234	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53090		"[{""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 transaminates an aromatic L-amino acid with 2-oxoglutarate to the corresponding oxo acid and L-glutamate (RHEA:17533); correct the swapped glutamate/2-oxoglutarate sides."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2112/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P53090"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53090 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-033_efe99c002bc3	gomodel:YeastPathways_PWY3O-214/65692e7e00000701	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000701 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000702."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/32; endpoint types: /individuals/123/type; /individuals/124/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-034_65740995f331	gomodel:YeastPathways_PWY3O-214/65692e7e00000694	BFO:0000050	GO:0006569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000694 BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/33; endpoint types: /individuals/117/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-035_edd3d23463b9	SGD:S000000349	pathwaymech:enables	gomodel:YeastPathways_PWY3O-214/65692e7e00000701	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000701 RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000716."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/34; endpoint types: /individuals/123/type; /individuals/136/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-036_1872f7965314	SGD:S000005446	pathwaymech:enables	gomodel:YeastPathways_PWY3O-214/65692e7e00000669	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000669 RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000676."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/35; endpoint types: /individuals/94/type; /individuals/99/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-037_568bed262294	SGD:S000004124	pathwaymech:enables	gomodel:YeastPathways_PWY3O-214/65692e7e00000627	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000627 RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000632."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/36; endpoint types: /individuals/56/type; /individuals/60/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-038_887f47caa969	gomodel:YeastPathways_PWY3O-214/65692e7e00000633	RO:0002233	CHEBI:17640	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000633 RO:0002233 gomodel:CHEBI_17640_2.6.1.28-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/37; endpoint types: /individuals/61/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-039_0a6df736c2f1	gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN	RO:0002233	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53090		"[{""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 transaminates an aromatic L-amino acid with 2-oxoglutarate to the corresponding oxo acid and L-glutamate (RHEA:17533); correct the swapped glutamate/2-oxoglutarate sides."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2112/comments/1/reaction""}]"	"[{""id"": ""UniProtKB:P53090"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53090 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-040_0295add45b37	gomodel:YeastPathways_PWY3O-214/65692e7e00000660	BFO:0000050	GO:0006569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000660 BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/39; endpoint types: /individuals/87/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-041_1d94b2c98bad	gomodel:YeastPathways_PWY3O-214/65692e7e00000621	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000621 BFO:0000066 gomodel:YeastPathways_PWY3O-214/65692e7e00000625."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/40; endpoint types: /individuals/51/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-043_2e7ed5204da0	SGD:S000001179	pathwaymech:enables	gomodel:2.6.1.28-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:2.6.1.28-RXN RO:0002333 gomodel:YHR137W-MONOMER_2.6.1.28-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/42; endpoint types: /individuals/42/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-044_bbcec2e786ba	gomodel:2.6.1.28-RXN	RO:0002234	CHEBI:58095	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:2.6.1.28-RXN RO:0002234 gomodel:CHEBI_58095_2.6.1.28-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/43; endpoint types: /individuals/42/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-045_85b6026e759e	gomodel:YeastPathways_PWY3O-214/65692e7e00000621	RO:0002233	CHEBI:17640	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000621 RO:0002233 gomodel:CHEBI_17640_2.6.1.28-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/44; endpoint types: /individuals/51/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-046_4030d8451244	gomodel:YeastPathways_PWY3O-214/65692e7e00000669	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000669 BFO:0000066 gomodel:YeastPathways_PWY3O-214/65692e7e00000677."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/45; endpoint types: /individuals/94/type; /individuals/100/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-047_796b23346477	gomodel:2.6.1.28-RXN	RO:0002233	CHEBI:57912	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:2.6.1.28-RXN RO:0002233 gomodel:CHEBI_57912_TRYPTOPHAN-AMINOTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/46; endpoint types: /individuals/42/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-048_da7aac9981c5	gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN BFO:0000066 gomodel:reaction_TRYPTOPHAN-AMINOTRANSFERASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/47; endpoint types: /individuals/13/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-049_2b444ee31648	gomodel:YeastPathways_PWY3O-214/65692e7e00000708	BFO:0000050	GO:0006569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000708 BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/48; endpoint types: /individuals/129/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-050_f96f826831cc	gomodel:YeastPathways_PWY3O-214/65692e7e00000627	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000627 BFO:0000066 gomodel:YeastPathways_PWY3O-214/65692e7e00000631."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/49; endpoint types: /individuals/56/type; /individuals/59/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-051_47797163add8	gomodel:1.1.1.190-RXN	RO:0002234	CHEBI:17890	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:1.1.1.190-RXN RO:0002234 gomodel:CHEBI_17890_1.1.1.190-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/50; endpoint types: /individuals/41/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-052_18f9a6637d31	gomodel:YeastPathways_PWY3O-214/65692e7e00000633	RO:0002234	CHEBI:18086	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000633 RO:0002234 gomodel:CHEBI_18086_4.1.1.74-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/51; endpoint types: /individuals/61/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-053_6b9288b240da	gomodel:YeastPathways_PWY3O-214/65692e7e00000627	RO:0002233	CHEBI:17640	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000627 RO:0002233 gomodel:CHEBI_17640_2.6.1.28-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/52; endpoint types: /individuals/56/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-054_f6529f5d3073	gomodel:YeastPathways_PWY3O-214/65692e7e00000708	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000708 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000710."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/53; endpoint types: /individuals/129/type; /individuals/131/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-055_96d3a0f86711	gomodel:1.1.1.190-RXN	RO:0002233	CHEBI:18086	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:1.1.1.190-RXN RO:0002233 gomodel:CHEBI_18086_4.1.1.74-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/54; endpoint types: /individuals/41/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-056_78a22d8a96cf	gomodel:YeastPathways_PWY3O-214/65692e7e00000660	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000660 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000661."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/55; endpoint types: /individuals/87/type; /individuals/88/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-057_6773f324c72e	gomodel:YeastPathways_PWY3O-214/65692e7e00000669	RO:0002234	CHEBI:17890	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000669 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000673."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/56; endpoint types: /individuals/94/type; /individuals/98/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-058_249d1047ad2e	gomodel:YeastPathways_PWY3O-214/65692e7e00000660	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000660 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000662."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/57; endpoint types: /individuals/87/type; /individuals/89/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-059_dde7d8ccd520	gomodel:YeastPathways_PWY3O-214/65692e7e00000669	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000669 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000672."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/58; endpoint types: /individuals/94/type; /individuals/97/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-060_b1318c291473	gomodel:YeastPathways_PWY3O-214/65692e7e00000708	RO:0002234	CHEBI:17890	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000708 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000711."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/59; endpoint types: /individuals/129/type; /individuals/132/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-061_ef30da2f4c44	gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN	RO:0002234	CHEBI:17640	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_17640_2.6.1.28-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/60; endpoint types: /individuals/13/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-062_7c3f01e56c89	gomodel:YeastPathways_PWY3O-214/65692e7e00000669	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000669 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000670."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/61; endpoint types: /individuals/94/type; /individuals/95/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-063_783c244b0c9e	gomodel:YeastPathways_PWY3O-214/65692e7e00000660	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000660 BFO:0000066 gomodel:YeastPathways_PWY3O-214/65692e7e00000668."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/62; endpoint types: /individuals/87/type; /individuals/93/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-064_2e9dc175d765	gomodel:YeastPathways_PWY3O-214/65692e7e00000708	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000708 BFO:0000066 gomodel:YeastPathways_PWY3O-214/65692e7e00000714."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/63; endpoint types: /individuals/129/type; /individuals/134/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-065_521cda73ee43	gomodel:YeastPathways_PWY3O-214/65692e7e00000669	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000669 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000671."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/64; endpoint types: /individuals/94/type; /individuals/96/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-066_7a7913fa5cf6	SGD:S000002327	pathwaymech:enables	gomodel:YeastPathways_PWY3O-214/65692e7e00000708	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000708 RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000715."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/65; endpoint types: /individuals/129/type; /individuals/135/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-067_223934089584	gomodel:YeastPathways_PWY3O-214/65692e7e00000669	BFO:0000050	GO:0006569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000669 BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/66; endpoint types: /individuals/94/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-068_b3ceaa91e942	gomodel:YeastPathways_PWY3O-214/65692e7e00000633	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000633 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000634."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/67; endpoint types: /individuals/61/type; /individuals/62/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-069_e61a8389167e	gomodel:YeastPathways_PWY3O-214/65692e7e00000701	RO:0002233	CHEBI:18086	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000701 RO:0002233 gomodel:CHEBI_18086_4.1.1.74-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/68; endpoint types: /individuals/123/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-070_60d168af7da7	gomodel:YeastPathways_PWY3O-214/65692e7e00000701	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000701 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000705."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/69; endpoint types: /individuals/123/type; /individuals/127/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-071_ac07e3f0d4d0	gomodel:YeastPathways_PWY3O-214/65692e7e00000694	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000694 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000696."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/70; endpoint types: /individuals/117/type; /individuals/119/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-072_42ff27764c7f	gomodel:4.1.1.74-RXN	RO:0002233	CHEBI:17640	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:4.1.1.74-RXN RO:0002233 gomodel:CHEBI_17640_2.6.1.28-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/71; endpoint types: /individuals/43/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-073_94a7671418a8	gomodel:YeastPathways_PWY3O-214/65692e7e00000633	BFO:0000050	GO:0006569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000633 BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/72; endpoint types: /individuals/61/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-074_a7e8fbc0ee20	gomodel:YeastPathways_PWY3O-214/65692e7e00000627	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000627 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000628."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/73; endpoint types: /individuals/56/type; /individuals/57/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-075_9781bb46bcb1	gomodel:YeastPathways_PWY3O-214/65692e7e00000621	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000621 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000622."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/74; endpoint types: /individuals/51/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-076_1da30a2a510e	gomodel:YeastPathways_PWY3O-214/65692e7e00000633	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000633 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000635."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/75; endpoint types: /individuals/61/type; /individuals/63/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-077_b9716ae9cf11	gomodel:2.6.1.28-RXN	RO:0002233	CHEBI:18005	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:2.6.1.28-RXN RO:0002233 gomodel:CHEBI_18005_2.6.1.28-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/76; endpoint types: /individuals/42/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-078_b66918f2383d	gomodel:YeastPathways_PWY3O-214/65692e7e00000660	RO:0002233	CHEBI:18086	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000660 RO:0002233 gomodel:CHEBI_18086_4.1.1.74-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/77; endpoint types: /individuals/87/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-079_c1b0c8668765	gomodel:2.6.1.28-RXN	RO:0002234	CHEBI:17640	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:2.6.1.28-RXN RO:0002234 gomodel:CHEBI_17640_2.6.1.28-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/78; endpoint types: /individuals/42/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-080_99651b220d93	gomodel:YeastPathways_PWY3O-214/65692e7e00000701	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000701 BFO:0000066 gomodel:YeastPathways_PWY3O-214/65692e7e00000707."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/79; endpoint types: /individuals/123/type; /individuals/128/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-081_beada8b91502	SGD:S000002788	pathwaymech:enables	gomodel:4.1.1.74-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:4.1.1.74-RXN RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000619."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/80; endpoint types: /individuals/43/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-082_5c88281f2376	SGD:S000003319	pathwaymech:enables	gomodel:YeastPathways_PWY3O-214/65692e7e00000621	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000621 RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000626."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/81; endpoint types: /individuals/51/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-083_d184887b6b01	gomodel:4.1.1.74-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:4.1.1.74-RXN RO:0002233 gomodel:CHEBI_15378_4.1.1.74-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/82; endpoint types: /individuals/43/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-084_1cc3382bc6e6	gomodel:YeastPathways_PWY3O-214/65692e7e00000701	RO:0002234	CHEBI:17890	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000701 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000704."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/83; endpoint types: /individuals/123/type; /individuals/126/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-085_3221ac415a14	SGD:S000004034	pathwaymech:enables	gomodel:YeastPathways_PWY3O-214/65692e7e00000633	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000633 RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000638."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/84; endpoint types: /individuals/61/type; /individuals/65/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-086_e0a5b7466107	gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN	RO:0002233	CHEBI:57912	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_57912_TRYPTOPHAN-AMINOTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/85; endpoint types: /individuals/13/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-087_37a23412f6bc	SGD:S000003170	pathwaymech:enables	gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000611."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/86; endpoint types: /individuals/13/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-088_b09ddc869e53	gomodel:YeastPathways_PWY3O-214/65692e7e00000694	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000694 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000697."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/87; endpoint types: /individuals/117/type; /individuals/120/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-089_ded7c1ea0548	gomodel:YeastPathways_PWY3O-214/65692e7e00000627	RO:0002234	CHEBI:18086	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000627 RO:0002234 gomodel:CHEBI_18086_4.1.1.74-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/88; endpoint types: /individuals/56/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_edge-090_ff24dba76c6f	gomodel:4.1.1.74-RXN	BFO:0000050	GO:0006569	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-214		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_assertion"": ""The model asserts gomodel:4.1.1.74-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214."", ""source_locator"": ""./YeastPathways_PWY3O-214.json#/facts/89; endpoint types: /individuals/43/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-214"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json"", ""title"": ""SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_location-36703d5e93fc_b5f89ee472cf	SGD:S000004688	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07246	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:1101965); ECO:0000269 (PubMed:2188098); ECO:0000269 (PubMed:2943982)	"[{""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_location-b5d74d4cb0f4_8bfb471efdf4	SGD:S000004688	RO:0001025	GO:0005743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07246	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	"[{""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 annotates location Mitochondrion inner membrane (SL-0168)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_location-c3e54c00840d_e9c095f35977	SGD:S000003225	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10127	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/302/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/302/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P10127"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P10127 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_location-83d9f7cee755_f1519015dd96	SGD:S000004918	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00331	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:2937632)	"[{""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00331"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00331 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_location-07b1015cc728_f760b844b333	SGD:S000000349	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38113	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38113"", ""source_assertion"": ""UniProtKB:P38113 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3563/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38113"", ""source_assertion"": ""UniProtKB:P38113 has the exact SGD cross-reference SGD:S000000349."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3563/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38113"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38113 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_location-7f1495b92dc9_294747dd35b2	SGD:S000005446	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00330	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	"[{""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00330"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00330 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_location-9ea10c14185b_0b349e6e26ba	SGD:S000004124	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16467	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P16467"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16467 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_location-19eb0ec36ddd_9eec1d7afa73	SGD:S000004124	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16467	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P16467"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16467 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_location-21257d2833bc_980f631761e3	SGD:S000001179	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38840	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1469/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 has the exact SGD cross-reference SGD:S000001179."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1469/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38840"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38840 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_location-b80b4f1b750d_6c38faaa1cfc	SGD:S000002327	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32771	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32771"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32771 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_location-091fe2fe90d3_2a3eecf58175	SGD:S000002327	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32771	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961)	"[{""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32771"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32771 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_location-48b2842e8c03_003c88c5931e	SGD:S000002788	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06408	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2752/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 has the exact SGD cross-reference SGD:S000002788."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2752/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q06408"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06408 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_location-ea1ab3242c76_9685870bd728	SGD:S000003319	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26263	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/742/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/742/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P26263"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P26263 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_location-e48c97df72e4_f8df64be0ba7	SGD:S000004034	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06169	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P06169"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06169 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_location-d8ee7aa94925_b7fd7339dcd0	SGD:S000004034	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06169	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P06169"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06169 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_location-ad4354e8d3df_f200d39e1fd1	SGD:S000003170	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53090	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2112/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 has the exact SGD cross-reference SGD:S000003170."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2112/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53090"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53090 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_cofactor-738cd0b35ac6_2f549564c19f	SGD:S000004688	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07246	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	"[{""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/comments/0/cofactors/0; /results/161/comments/0/note""}, {""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P07246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_cofactor-a5e2dcd48dc5_2648e271e1c8	SGD:S000003225	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10127	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3282541) Zinc. May bind iron when zinc levels are limiting. UniProt note evidence: ECO:0000269 (PubMed:3282541)	"[{""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/comments/0/cofactors/0; /results/302/comments/0/note""}, {""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P10127"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P10127 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_cofactor-ae583f346b28_869031e06103	SGD:S000003225	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10127	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3282541) Zinc. May bind iron when zinc levels are limiting. UniProt note evidence: ECO:0000269 (PubMed:3282541)	"[{""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 annotates CHEBI:29033 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/comments/0/cofactors/1; /results/302/comments/0/note""}, {""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P10127"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P10127 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_cofactor-ea44646ed080_09fe32eef40d	SGD:S000004918	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00331	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	"[{""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/comments/0/cofactors/0; /results/23/comments/0/note""}, {""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00331"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00331 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_cofactor-339a304fe175_cd8c70246a98	SGD:S000000349	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38113	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	"[{""reference_id"": ""UniProtKB:P38113"", ""source_assertion"": ""UniProtKB:P38113 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3563/comments/0/cofactors/0; /results/3563/comments/0/note""}, {""reference_id"": ""UniProtKB:P38113"", ""source_assertion"": ""UniProtKB:P38113 has the exact SGD cross-reference SGD:S000000349."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3563/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38113"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38113 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_cofactor-d020d7cd99ba_2f9d4958be9b	SGD:S000005446	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00330	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849)	"[{""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/comments/0/cofactors/0; /results/22/comments/0/note""}, {""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00330"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00330 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_cofactor-93748e431c03_e16edcc7b848	SGD:S000004124	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16467	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/comments/0/cofactors/0; /results/439/comments/0/note""}, {""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P16467"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16467 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_cofactor-43ef6e61857d_7031640dae90	SGD:S000004124	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16467	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/comments/1/cofactors/0; /results/439/comments/1/note""}, {""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P16467"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16467 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_cofactor-eb2a9050a8eb_e26362baeeaf	SGD:S000001179	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38840	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:O84395)	"[{""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1469/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 has the exact SGD cross-reference SGD:S000001179."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1469/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38840"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38840 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_cofactor-5ec0450d58bc_6fd0e8898574	SGD:S000002327	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32771	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06525) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06525)	"[{""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/990/comments/0/cofactors/0; /results/990/comments/0/note""}, {""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/990/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32771"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32771 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_cofactor-94921f5c2d4f_3327666ffe63	SGD:S000002788	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06408	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/comments/0/cofactors/0; /results/2752/comments/0/note""}, {""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 has the exact SGD cross-reference SGD:S000002788."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q06408"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06408 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_cofactor-2aff8723af5a_2ae8b84be314	SGD:S000002788	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q06408	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/comments/1/cofactors/0; /results/2752/comments/1/note""}, {""reference_id"": ""UniProtKB:Q06408"", ""source_assertion"": ""UniProtKB:Q06408 has the exact SGD cross-reference SGD:S000002788."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q06408"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q06408 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_cofactor-437eea628a9f_520209a14141	SGD:S000003319	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26263	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/comments/0/cofactors/0; /results/742/comments/0/note""}, {""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P26263"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P26263 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_cofactor-be7459c89012_80bd27f4a75a	SGD:S000003319	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26263	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/comments/1/cofactors/0; /results/742/comments/1/note""}, {""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P26263"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P26263 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_cofactor-81ce8a7e7be7_02bf1156ff7e	SGD:S000004034	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06169	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10651824) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000269 (PubMed:10651824)	"[{""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/comments/0/cofactors/0; /results/127/comments/0/note""}, {""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P06169"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06169 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_cofactor-5cf6d8babbe2_ff13df575b55	SGD:S000004034	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06169	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10651824) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000269 (PubMed:10651824)	"[{""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/comments/1/cofactors/0; /results/127/comments/1/note""}, {""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P06169"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06169 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-214_cofactor-46a0dec0bfb8_d0535ea9d9b9	SGD:S000003170	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53090	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:23893908)	"[{""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 has the exact SGD cross-reference SGD:S000003170."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53090"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53090 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-001_55b835a95b76	gomodel:CHORISMATEMUT-RXN	RO:0002234	CHEBI:29934	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:CHORISMATEMUT-RXN RO:0002234 gomodel:CHEBI_29934_CHORISMATEMUT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/0; endpoint types: /individuals/6/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-002_ffbafe7ec008	gomodel:TYROSINE-AMINOTRANSFERASE-RXN	RO:0002233	CHEBI:36242	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_36242_TYROSINE-AMINOTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/1; endpoint types: /individuals/8/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-003_b003543a3b9d	gomodel:TYROSINE-AMINOTRANSFERASE-RXN	RO:0002234	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002234 gomodel:YeastPathways_PWY3O-4120/6690711d00000271."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/2; endpoint types: /individuals/8/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-004_69a732cd1418	gomodel:PREPHENATE-DEHYDROGENASE-NADP+-RXN	RO:0002234	CHEBI:36242	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:PREPHENATE-DEHYDROGENASE-NADP+-RXN RO:0002234 gomodel:CHEBI_36242_TYROSINE-AMINOTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/3; endpoint types: /individuals/28/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-005_8ee3828b1c88	gomodel:TYROSINE-AMINOTRANSFERASE-RXN	BFO:0000050	GO:0006571	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4120/YeastPathways_PWY3O-4120."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/4; endpoint types: /individuals/8/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-006_d17707964c94	gomodel:PREPHENATE-DEHYDROGENASE-NADP+-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:PREPHENATE-DEHYDROGENASE-NADP+-RXN BFO:0000066 gomodel:reaction_PREPHENATE-DEHYDROGENASE-NADP+-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/5; endpoint types: /individuals/28/type; /individuals/50/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-007_cf46ccabf06f	gomodel:PREPHENATE-DEHYDROGENASE-NADP+-RXN	RO:0002233	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:PREPHENATE-DEHYDROGENASE-NADP+-RXN RO:0002233 gomodel:CHEBI_58349_PREPHENATE-DEHYDROGENASE-NADP+-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/6; endpoint types: /individuals/28/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-008_9c861039b254	gomodel:CHORISMATEMUT-RXN	RO:0002233	CHEBI:29748	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:CHORISMATEMUT-RXN RO:0002233 gomodel:CHEBI_29748_CHORISMATEMUT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/7; endpoint types: /individuals/6/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-009_cb893a3da5de	gomodel:PREPHENATE-DEHYDROGENASE-NADP+-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:PREPHENATE-DEHYDROGENASE-NADP+-RXN RO:0002234 gomodel:CHEBI_16526_PREPHENATE-DEHYDROGENASE-NADP+-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/8; endpoint types: /individuals/28/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-010_6e1a72e52231	SGD:S000006264	pathwaymech:enables	gomodel:CHORISMATEMUT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:CHORISMATEMUT-RXN RO:0002333 gomodel:YPR060C-MONOMER_CHORISMATEMUT-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/9; endpoint types: /individuals/6/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-011_846dbc42e2b5	gomodel:PREPHENATE-DEHYDROGENASE-NADP+-RXN	RO:0002233	CHEBI:29934	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:PREPHENATE-DEHYDROGENASE-NADP+-RXN RO:0002233 gomodel:CHEBI_29934_CHORISMATEMUT-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/10; endpoint types: /individuals/28/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-012_d4ef8064b13e	gomodel:TYROSINE-AMINOTRANSFERASE-RXN	RO:0002234	CHEBI:58315	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_58315_RXN3O-4157."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/11; endpoint types: /individuals/8/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-013_4cd2e7dd5e23	gomodel:RXN3O-4157	RO:0002233	CHEBI:36242	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4157 RO:0002233 gomodel:CHEBI_36242_TYROSINE-AMINOTRANSFERASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/12; endpoint types: /individuals/7/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-014_7de120ea4ba6	gomodel:PREPHENATE-DEHYDROGENASE-NADP+-RXN	RO:0002234	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:PREPHENATE-DEHYDROGENASE-NADP+-RXN RO:0002234 gomodel:CHEBI_57783_PREPHENATE-DEHYDROGENASE-NADP+-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/13; endpoint types: /individuals/28/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-015_f01261f72b14	gomodel:RXN3O-4157	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4157 BFO:0000066 gomodel:reaction_RXN3O-4157_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/14; endpoint types: /individuals/7/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-016_4f769200b497	gomodel:TYROSINE-AMINOTRANSFERASE-RXN	RO:0002233	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002233 gomodel:YeastPathways_PWY3O-4120/6690711d00000270."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/15; endpoint types: /individuals/8/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-017_c4e44aa3b434	SGD:S000001179	pathwaymech:enables	gomodel:RXN3O-4157	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4157 RO:0002333 gomodel:YHR137W-MONOMER_RXN3O-4157_controller."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/16; endpoint types: /individuals/7/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-018_21d51a702b1c	gomodel:RXN3O-4157	RO:0002234	CHEBI:15361	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4157 RO:0002234 gomodel:CHEBI_15361_RXN3O-4157."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/17; endpoint types: /individuals/7/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-019_1cd36a394bbf	gomodel:TYROSINE-AMINOTRANSFERASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN BFO:0000066 gomodel:reaction_TYROSINE-AMINOTRANSFERASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/18; endpoint types: /individuals/8/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-020_ad2cba571e4c	SGD:S000000370	pathwaymech:enables	gomodel:PREPHENATE-DEHYDROGENASE-NADP+-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:PREPHENATE-DEHYDROGENASE-NADP+-RXN RO:0002333 gomodel:YBR166C-MONOMER_PREPHENATE-DEHYDROGENASE-NADP+-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/19; endpoint types: /individuals/28/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-021_23ee2a7bd2cb	gomodel:RXN3O-4157	RO:0002233	CHEBI:57972	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4157 RO:0002233 gomodel:CHEBI_57972_RXN3O-4157."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/20; endpoint types: /individuals/7/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-022_48d090c77dcb	gomodel:RXN3O-4157	BFO:0000050	GO:0006571	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4157 BFO:0000050 gomodel:YeastPathways_PWY3O-4120/YeastPathways_PWY3O-4120."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/21; endpoint types: /individuals/7/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-023_19b2c44caae2	gomodel:CHORISMATEMUT-RXN	BFO:0000050	GO:0006571	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:CHORISMATEMUT-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4120/YeastPathways_PWY3O-4120."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/22; endpoint types: /individuals/6/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-024_c5797066e12a	gomodel:CHORISMATEMUT-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:CHORISMATEMUT-RXN BFO:0000066 gomodel:reaction_CHORISMATEMUT-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/23; endpoint types: /individuals/6/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-025_8010c595979b	gomodel:PREPHENATE-DEHYDROGENASE-NADP+-RXN	BFO:0000050	GO:0006571	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:PREPHENATE-DEHYDROGENASE-NADP+-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4120/YeastPathways_PWY3O-4120."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/24; endpoint types: /individuals/28/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-026_0a60caa8dd57	gomodel:RXN3O-4157	RO:0002234	CHEBI:58315	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4157 RO:0002234 gomodel:CHEBI_58315_RXN3O-4157."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/25; endpoint types: /individuals/7/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_edge-027_264a4839a627	SGD:S000003170	pathwaymech:enables	gomodel:TYROSINE-AMINOTRANSFERASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4120		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_assertion"": ""The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002333 gomodel:YeastPathways_PWY3O-4120/6690711d00000272."", ""source_locator"": ""./YeastPathways_PWY3O-4120.json#/facts/26; endpoint types: /individuals/8/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4120"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-08-09; member ./YeastPathways_PWY3O-4120.json"", ""title"": ""SGD GO-CAM tyrosine biosynthesis - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_location-b3fbf570a53d_f4d3c70682ed	SGD:S000006264	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32178	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12455686)	"[{""reference_id"": ""UniProtKB:P32178"", ""source_assertion"": ""UniProtKB:P32178 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/855/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32178"", ""source_assertion"": ""UniProtKB:P32178 has the exact SGD cross-reference SGD:S000006264."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/855/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32178"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32178 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_location-21257d2833bc_03f7123462eb	SGD:S000001179	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38840	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1469/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 has the exact SGD cross-reference SGD:S000001179."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1469/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38840"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38840 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_location-ad4354e8d3df_3ce842680d70	SGD:S000003170	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53090	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2112/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 has the exact SGD cross-reference SGD:S000003170."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2112/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53090"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53090 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_cofactor-eb2a9050a8eb_7a6703446468	SGD:S000001179	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38840	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:O84395)	"[{""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1469/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P38840"", ""source_assertion"": ""UniProtKB:P38840 has the exact SGD cross-reference SGD:S000001179."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1469/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38840"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38840 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4120_cofactor-46a0dec0bfb8_95e29710c59b	SGD:S000003170	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53090	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:23893908)	"[{""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P53090"", ""source_assertion"": ""UniProtKB:P53090 has the exact SGD cross-reference SGD:S000003170."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53090"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53090 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-1_5e9f17acb785	CHEBI:61472	pathwaymech:consumes	WikiPathways:WP287/id1105b8d9	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id1105b8d9 connects normalized CHEBI:61472 as an input of interaction id1105b8d9."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id1105b8d9']/Graphics; /Pathway/DataNode[@GraphId='f8109']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-2_3f4283a08a9b	WikiPathways:WP287/id1105b8d9	pathwaymech:produces	CHEBI:61473	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id1105b8d9 connects normalized CHEBI:61473 as an output of interaction id1105b8d9."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id1105b8d9']/Graphics; /Pathway/DataNode[@GraphId='ae06e']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-3_be17b69bbf93	CHEBI:30763	pathwaymech:consumes	WikiPathways:WP287/id46b5e257	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id46b5e257 connects normalized CHEBI:30763 as an input of interaction id46b5e257."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id46b5e257']/Graphics; /Pathway/DataNode[@GraphId='b9cc2']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-4_03590ff24792	WikiPathways:WP287/id46b5e257	pathwaymech:produces	CHEBI:84492	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id46b5e257 connects normalized CHEBI:84492 as an output of interaction id46b5e257."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id46b5e257']/Graphics; /Pathway/DataNode[@GraphId='f13a3']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-5_fae0c86f5cfd	CHEBI:84492	pathwaymech:consumes	WikiPathways:WP287/id4c332e28	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id4c332e28 connects normalized CHEBI:84492 as an input of interaction id4c332e28."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id4c332e28']/Graphics; /Pathway/DataNode[@GraphId='f13a3']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-6_513848820e02	WikiPathways:WP287/id4c332e28	pathwaymech:produces	CHEBI:58373	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id4c332e28 connects normalized CHEBI:58373 as an output of interaction id4c332e28."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id4c332e28']/Graphics; /Pathway/DataNode[@GraphId='b725a']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-7_bb4357de877a	CHEBI:57916	pathwaymech:consumes	WikiPathways:WP287/id55520bdd	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id55520bdd connects normalized CHEBI:57916 as an input of interaction id55520bdd."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id55520bdd']/Graphics; /Pathway/DataNode[@GraphId='ca84f']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-8_bc499a2cd7dd	WikiPathways:WP287/id55520bdd	pathwaymech:produces	CHEBI:1109	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id55520bdd connects normalized CHEBI:1109 as an output of interaction id55520bdd."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id55520bdd']/Graphics; /Pathway/DataNode[@GraphId='aff04']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-9_ae3fa3044481	CHEBI:58373	pathwaymech:consumes	WikiPathways:WP287/id646fb25b	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id646fb25b connects normalized CHEBI:58373 as an input of interaction id646fb25b."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id646fb25b']/Graphics; /Pathway/DataNode[@GraphId='b725a']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-10_84088b1e8708	WikiPathways:WP287/id646fb25b	pathwaymech:produces	CHEBI:57916	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id646fb25b connects normalized CHEBI:57916 as an output of interaction id646fb25b."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id646fb25b']/Graphics; /Pathway/DataNode[@GraphId='ca84f']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-11_6d2b03053e34	CHEBI:1109	pathwaymech:consumes	WikiPathways:WP287/id74367dd4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id74367dd4 connects normalized CHEBI:1109 as an input of interaction id74367dd4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id74367dd4']/Graphics; /Pathway/DataNode[@GraphId='aff04']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-12_6987557b7806	WikiPathways:WP287/id74367dd4	pathwaymech:produces	CHEBI:61472	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id74367dd4 connects normalized CHEBI:61472 as an output of interaction id74367dd4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id74367dd4']/Graphics; /Pathway/DataNode[@GraphId='f8109']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-13_8ac29b53bb5a	CHEBI:64253	pathwaymech:consumes	WikiPathways:WP287/id86d34e80	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id86d34e80 connects normalized CHEBI:64253 as an input of interaction id86d34e80."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id86d34e80']/Graphics; /Pathway/DataNode[@GraphId='e611b']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-14_8a829d4088e7	WikiPathways:WP287/id86d34e80	pathwaymech:produces	CHEBI:52970	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id86d34e80 connects normalized CHEBI:52970 as an output of interaction id86d34e80."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id86d34e80']/Graphics; /Pathway/DataNode[@GraphId='c6f']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-15_0042e1a19360	CHEBI:61473	pathwaymech:consumes	WikiPathways:WP287/idac01794e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML idac01794e connects normalized CHEBI:61473 as an input of interaction idac01794e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idac01794e']/Graphics; /Pathway/DataNode[@GraphId='ae06e']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-16_7d7699df210b	WikiPathways:WP287/idac01794e	pathwaymech:produces	CHEBI:64253	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML idac01794e connects normalized CHEBI:64253 as an output of interaction idac01794e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idac01794e']/Graphics; /Pathway/DataNode[@GraphId='e611b']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-17_b3419826aabe	CHEBI:15378	pathwaymech:consumes	WikiPathways:WP287/id55520bdd	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id1cd7c8ca connects normalized CHEBI:15378 as an input of interaction id55520bdd."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id1cd7c8ca']/Graphics; /Pathway/DataNode[@GraphId='b03a6']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-18_777cefe047f9	WikiPathways:WP287/id74367dd4	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id20ea8209 connects normalized CHEBI:58349 as an output of interaction id74367dd4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id20ea8209']/Graphics; /Pathway/DataNode[@GraphId='f5dc0']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-19_914d78251420	WikiPathways:WP287/id74367dd4	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id20ea8209 connects normalized CHEBI:15377 as an output of interaction id74367dd4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id20ea8209']/Graphics; /Pathway/DataNode[@GraphId='a40ba']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-20_4ff5c634904a	SGD:S000003487	pathwaymech:catalyzes	WikiPathways:WP287/id74367dd4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id2a2637f6 connects normalized SGD:S000003487 as a catalyst of interaction id74367dd4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id2a2637f6']/Graphics; /Pathway/DataNode[@GraphId='a9a']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-21_c9cc3f90f7f2	CHEBI:59789	pathwaymech:consumes	WikiPathways:WP287/id646fb25b	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id2b26e18c connects normalized CHEBI:59789 as an input of interaction id646fb25b."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id2b26e18c']/Graphics; /Pathway/DataNode[@GraphId='e06c8']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-22_91179125a79e	CHEBI:59789	pathwaymech:consumes	WikiPathways:WP287/id86d34e80	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id2dd44a25 connects normalized CHEBI:59789 as an input of interaction id86d34e80."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id2dd44a25']/Graphics; /Pathway/DataNode[@GraphId='a9290']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-23_ad3b71315d39	SGD:S000003487	pathwaymech:catalyzes	WikiPathways:WP287/id4c332e28	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id3498e219 connects normalized SGD:S000003487 as a catalyst of interaction id4c332e28."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id3498e219']/Graphics; /Pathway/DataNode[@GraphId='f061c']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-24_af85ea200124	CHEBI:17499	pathwaymech:consumes	WikiPathways:WP287/idac01794e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id55f10a3 connects normalized CHEBI:17499 as an input of interaction idac01794e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id55f10a3']/Graphics; /Pathway/DataNode[@GraphId='daca3']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-25_f61286857909	CHEBI:15379	pathwaymech:consumes	WikiPathways:WP287/idac01794e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id55f10a3 connects normalized CHEBI:15379 as an input of interaction idac01794e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id55f10a3']/Graphics; /Pathway/DataNode[@GraphId='e9b89']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-26_30895a720767	CHEBI:58179	pathwaymech:consumes	WikiPathways:WP287/id46b5e257	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id56a4dcf9 connects normalized CHEBI:58179 as an input of interaction id46b5e257."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id56a4dcf9']/Graphics; /Pathway/DataNode[@GraphId='ac7c1']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-27_b81812f08e2b	CHEBI:15379	pathwaymech:consumes	WikiPathways:WP287/id4c332e28	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id5775a183 connects normalized CHEBI:15379 as an input of interaction id4c332e28."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5775a183']/Graphics; /Pathway/DataNode[@GraphId='fa6af']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-28_4df060a08f2a	CHEBI:15378	pathwaymech:consumes	WikiPathways:WP287/id4c332e28	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id5775a183 connects normalized CHEBI:15378 as an input of interaction id4c332e28."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5775a183']/Graphics; /Pathway/DataNode[@GraphId='e5334']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-29_104aa9e6b870	CHEBI:15378	pathwaymech:consumes	WikiPathways:WP287/id74367dd4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id58dff702 connects normalized CHEBI:15378 as an input of interaction id74367dd4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id58dff702']/Graphics; /Pathway/DataNode[@GraphId='c99ad']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-30_d90dc26f0ce8	CHEBI:57783	pathwaymech:consumes	WikiPathways:WP287/id74367dd4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id58dff702 connects normalized CHEBI:57783 as an input of interaction id74367dd4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id58dff702']/Graphics; /Pathway/DataNode[@GraphId='c718e']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-31_09bc0921deee	CHEBI:15379	pathwaymech:consumes	WikiPathways:WP287/id74367dd4	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id58dff702 connects normalized CHEBI:15379 as an input of interaction id74367dd4."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id58dff702']/Graphics; /Pathway/DataNode[@GraphId='c2a0a']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-32_d6c1f326d0a4	SGD:S000005456	pathwaymech:catalyzes	WikiPathways:WP287/id86d34e80	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id5d515d46 connects normalized SGD:S000005456 as a catalyst of interaction id86d34e80."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id5d515d46']/Graphics; /Pathway/DataNode[@GraphId='f94']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-33_595deaeec650	WikiPathways:WP287/id4c332e28	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id65cb6048 connects normalized CHEBI:15377 as an output of interaction id4c332e28."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id65cb6048']/Graphics; /Pathway/DataNode[@GraphId='f6167']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-34_253a711685da	SGD:S000005324	pathwaymech:catalyzes	WikiPathways:WP287/id46b5e257	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id6ba28781 connects normalized SGD:S000005324 as a catalyst of interaction id46b5e257."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id6ba28781']/Graphics; /Pathway/DataNode[@GraphId='c77']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-35_2fbf58e9f7d4	WikiPathways:WP287/id86d34e80	pathwaymech:produces	CHEBI:57856	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id7872d0a9 connects normalized CHEBI:57856 as an output of interaction id86d34e80."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id7872d0a9']/Graphics; /Pathway/DataNode[@GraphId='e5d57']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-36_4d431a6c5a01	WikiPathways:WP287/id86d34e80	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id7872d0a9 connects normalized CHEBI:15378 as an output of interaction id86d34e80."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id7872d0a9']/Graphics; /Pathway/DataNode[@GraphId='f7037']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-37_06b8075f5e00	SGD:S000005456	pathwaymech:catalyzes	WikiPathways:WP287/id646fb25b	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id79c3d548 connects normalized SGD:S000005456 as a catalyst of interaction id646fb25b."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id79c3d548']/Graphics; /Pathway/DataNode[@GraphId='ab9']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-38_de0358a33b6d	SGD:S000005651	pathwaymech:catalyzes	WikiPathways:WP287/idac01794e	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id7c4a96b5 connects normalized SGD:S000005651 as a catalyst of interaction idac01794e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id7c4a96b5']/Graphics; /Pathway/DataNode[@GraphId='d8e']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-39_e6d266f4976e	WikiPathways:WP287/id1105b8d9	pathwaymech:produces	CHEBI:57856	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id8e1968ee connects normalized CHEBI:57856 as an output of interaction id1105b8d9."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id8e1968ee']/Graphics; /Pathway/DataNode[@GraphId='bc043']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-40_3d505e1ee66a	WikiPathways:WP287/id1105b8d9	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML id8e1968ee connects normalized CHEBI:15378 as an output of interaction id1105b8d9."", ""source_locator"": ""/Pathway/Interaction[@GraphId='id8e1968ee']/Graphics; /Pathway/DataNode[@GraphId='b4452']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-41_d5fdd47c6762	CHEBI:59789	pathwaymech:consumes	WikiPathways:WP287/id1105b8d9	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML ida32188de connects normalized CHEBI:59789 as an input of interaction id1105b8d9."", ""source_locator"": ""/Pathway/Interaction[@GraphId='ida32188de']/Graphics; /Pathway/DataNode[@GraphId='ebc42']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-42_628ddd7c0faf	WikiPathways:WP287/id55520bdd	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML idaa021088 connects normalized CHEBI:16526 as an output of interaction id55520bdd."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idaa021088']/Graphics; /Pathway/DataNode[@GraphId='fef77']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-43_284d607001e6	WikiPathways:WP287/id46b5e257	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML idb548d439 connects normalized CHEBI:33019 as an output of interaction id46b5e257."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idb548d439']/Graphics; /Pathway/DataNode[@GraphId='d77']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-44_6acd6ffc0135	SGD:S000004578	pathwaymech:catalyzes	WikiPathways:WP287/id1105b8d9	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML idc2f01468 connects normalized SGD:S000004578 as a catalyst of interaction id1105b8d9."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idc2f01468']/Graphics; /Pathway/DataNode[@GraphId='de1']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-45_b63ee86fb5fa	WikiPathways:WP287/idac01794e	pathwaymech:produces	CHEBI:15339	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML idf1b486b8 connects normalized CHEBI:15339 as an output of interaction idac01794e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idf1b486b8']/Graphics; /Pathway/DataNode[@GraphId='fc22f']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-46_be12b84e7cc6	WikiPathways:WP287/idac01794e	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML idf1b486b8 connects normalized CHEBI:15377 as an output of interaction idac01794e."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idf1b486b8']/Graphics; /Pathway/DataNode[@GraphId='e7e6e']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-47_9d8cbea929ab	WikiPathways:WP287/id646fb25b	pathwaymech:produces	CHEBI:57856	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML idffbd7493 connects normalized CHEBI:57856 as an output of interaction id646fb25b."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idffbd7493']/Graphics; /Pathway/DataNode[@GraphId='e120c']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_causal-review-48_33240e5d1197	WikiPathways:WP287/id646fb25b	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	WikiPathways:WP287		"[{""reference_id"": ""WikiPathways:WP287"", ""source_assertion"": ""GPML idffbd7493 connects normalized CHEBI:15378 as an output of interaction id646fb25b."", ""source_locator"": ""/Pathway/Interaction[@GraphId='idffbd7493']/Graphics; /Pathway/DataNode[@GraphId='d056a']""}]"	"[{""id"": ""WikiPathways:WP287"", ""source_sha256"": ""cbedd94b5988d9722664980405f74f81372d730c355f2eb0cf5074eb4fbdcb76"", ""source_version"": ""WP287_r20260921194738"", ""title"": ""WP287 native structured pathway source"", ""url"": ""https://www.wikipathways.org/wikipathways-assets/pathways/WP287/WP287.gpml""}]"	""
pathwaymech:WikiPathways_WP287_cofactor-78dc6a615efa_5b0c3732dd2d	SGD:S000003487	pathwaymech:has_cofactor	CHEBI:57692	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53318	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The caution limits deamination in other taxa and does not negate the yeast FAD cofactor annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03193); ECO:0000269 (PubMed:26808124)	"[{""reference_id"": ""UniProtKB:P53318"", ""source_assertion"": ""UniProtKB:P53318 annotates CHEBI:57692 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2200/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P53318"", ""source_assertion"": ""UniProtKB:P53318 has the exact SGD cross-reference SGD:S000003487."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2200/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53318"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P53318 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP287_cofactor-e7641fe11f55_aea6a246f06c	SGD:S000005456	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P27680	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03190)	"[{""reference_id"": ""UniProtKB:P27680"", ""source_assertion"": ""UniProtKB:P27680 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/767/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P27680"", ""source_assertion"": ""UniProtKB:P27680 has the exact SGD cross-reference SGD:S000005456."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/767/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P27680"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P27680 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP287_cofactor-7d5b235207de_fe541f677d25	SGD:S000005324	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32378	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03189); ECO:0000269 (PubMed:1740455)	"[{""reference_id"": ""UniProtKB:P32378"", ""source_assertion"": ""UniProtKB:P32378 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3413/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P32378"", ""source_assertion"": ""UniProtKB:P32378 has the exact SGD cross-reference SGD:S000005324."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3413/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32378"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P32378 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:WikiPathways_WP287_cofactor-80d8170f8e3f_19c6b6c9d2fb	SGD:S000005651	pathwaymech:has_cofactor	CHEBI:24875	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P41735	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: Carbon catabolite repression was an indirect phenotype, not the enzyme function; retain the inferred iron cofactor annotation without adding regulatory causality. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03194) Binds 2 iron ions per subunit. UniProt note evidence: ECO:0000255 (HAMAP-Rule:MF_03194)	"[{""reference_id"": ""UniProtKB:P41735"", ""source_assertion"": ""UniProtKB:P41735 annotates CHEBI:24875 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1807/comments/0/cofactors/0; /results/1807/comments/0/note""}, {""reference_id"": ""UniProtKB:P41735"", ""source_assertion"": ""UniProtKB:P41735 has the exact SGD cross-reference SGD:S000005651."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1807/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P41735"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P41735 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-001_a212962044e0	gomodel:GLUCOSAMINEPNACETYLTRANS-RXN	RO:0002234	CHEBI:15784	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:GLUCOSAMINEPNACETYLTRANS-RXN RO:0002234 gomodel:CHEBI_57513_GLUCOSAMINEPNACETYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/0; endpoint types: /individuals/13/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-002_e7bec6763da1	SGD:S000002261	pathwaymech:enables	gomodel:NAG1P-URIDYLTRANS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:NAG1P-URIDYLTRANS-RXN RO:0002333 gomodel:YDL103C-MONOMER_NAG1P-URIDYLTRANS-RXN_controller."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/1; endpoint types: /individuals/15/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-003_9dbbb864fc67	gomodel:NAG1P-URIDYLTRANS-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:NAG1P-URIDYLTRANS-RXN BFO:0000066 gomodel:reaction_NAG1P-URIDYLTRANS-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/2; endpoint types: /individuals/15/type; /individuals/47/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-004_ba07fd9cab8e	gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN BFO:0000066 gomodel:reaction_L-GLN-FRUCT-6-P-AMINOTRANS-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/3; endpoint types: /individuals/14/type; /individuals/46/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-005_a8045a39c09b	gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN	RO:0002413	gomodel:NAG1P-URIDYLTRANS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN RO:0002413 gomodel:NAG1P-URIDYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/4; endpoint types: /individuals/16/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-006_882022e2c68a	gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN BFO:0000066 gomodel:reaction_PHOSACETYLGLUCOSAMINEMUT-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/5; endpoint types: /individuals/16/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-007_1e7fb1df9d53	gomodel:GLUCOSAMINEPNACETYLTRANS-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:GLUCOSAMINEPNACETYLTRANS-RXN BFO:0000066 gomodel:reaction_GLUCOSAMINEPNACETYLTRANS-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/6; endpoint types: /individuals/13/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-008_a556ff42eebe	gomodel:GLUCOSAMINEPNACETYLTRANS-RXN	RO:0002233	CHEBI:15351	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:GLUCOSAMINEPNACETYLTRANS-RXN RO:0002233 gomodel:CHEBI_57288_GLUCOSAMINEPNACETYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/7; endpoint types: /individuals/13/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-009_48713513c11e	SGD:S000001877	pathwaymech:enables	gomodel:GLUCOSAMINEPNACETYLTRANS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:GLUCOSAMINEPNACETYLTRANS-RXN RO:0002333 gomodel:YFL017C-MONOMER_GLUCOSAMINEPNACETYLTRANS-RXN_controller."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/8; endpoint types: /individuals/13/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-010_e540bd506928	gomodel:GLUCOSAMINEPNACETYLTRANS-RXN	RO:0002233	CHEBI:12962	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:GLUCOSAMINEPNACETYLTRANS-RXN RO:0002233 gomodel:CHEBI_15873_L-GLN-FRUCT-6-P-AMINOTRANS-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/9; endpoint types: /individuals/13/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-011_d56dbbf88291	gomodel:GLUCOSAMINEPNACETYLTRANS-RXN	BFO:0000050	GO:0006048	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:GLUCOSAMINEPNACETYLTRANS-RXN BFO:0000050 gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY/YeastPathways_UDPNAGSYN-YEAST-PWY."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/10; endpoint types: /individuals/13/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-012_09e0839ba0b9	gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN	RO:0002234	CHEBI:16015	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN RO:0002234 gomodel:CHEBI_29985_L-GLN-FRUCT-6-P-AMINOTRANS-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/11; endpoint types: /individuals/14/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-013_f6bd9b6fbf16	gomodel:NAG1P-URIDYLTRANS-RXN	BFO:0000050	GO:0006048	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:NAG1P-URIDYLTRANS-RXN BFO:0000050 gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY/YeastPathways_UDPNAGSYN-YEAST-PWY."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/12; endpoint types: /individuals/15/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-014_4a1dae01a3c1	gomodel:GLUCOSAMINEPNACETYLTRANS-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:GLUCOSAMINEPNACETYLTRANS-RXN RO:0002234 gomodel:CHEBI_15378_GLUCOSAMINEPNACETYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/13; endpoint types: /individuals/13/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-015_2dcc21f3d902	gomodel:NAG1P-URIDYLTRANS-RXN	RO:0002234	CHEBI:16264	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:NAG1P-URIDYLTRANS-RXN RO:0002234 gomodel:CHEBI_57705_NAG1P-URIDYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/14; endpoint types: /individuals/15/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-016_07a4306463be	gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN	RO:0002413	gomodel:GLUCOSAMINEPNACETYLTRANS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN RO:0002413 gomodel:GLUCOSAMINEPNACETYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/15; endpoint types: /individuals/14/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-017_8e3f0c395463	gomodel:NAG1P-URIDYLTRANS-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:NAG1P-URIDYLTRANS-RXN RO:0002233 gomodel:CHEBI_15378_NAG1P-URIDYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/16; endpoint types: /individuals/15/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-018_cfd6f6cbf17c	gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN	RO:0002234	CHEBI:16446	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN RO:0002234 gomodel:CHEBI_57776_PHOSACETYLGLUCOSAMINEMUT-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/17; endpoint types: /individuals/16/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-019_68dc290b8da1	SGD:S000001587	pathwaymech:enables	gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN RO:0002333 gomodel:YKL104C-MONOMER_L-GLN-FRUCT-6-P-AMINOTRANS-RXN_controller."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/18; endpoint types: /individuals/14/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-020_4cf9ccfccb6c	gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN	BFO:0000050	GO:0006048	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN BFO:0000050 gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY/YeastPathways_UDPNAGSYN-YEAST-PWY."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/19; endpoint types: /individuals/16/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-021_a0f1e38b6d73	gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN	RO:0002233	CHEBI:16084	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN RO:0002233 gomodel:CHEBI_57634_L-GLN-FRUCT-6-P-AMINOTRANS-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/20; endpoint types: /individuals/14/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-022_faa4771bc512	gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN	RO:0002233	CHEBI:58359	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN RO:0002233 gomodel:CHEBI_58359_L-GLN-FRUCT-6-P-AMINOTRANS-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/21; endpoint types: /individuals/14/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-023_01beed63ef40	SGD:S000000784	pathwaymech:enables	gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN RO:0002333 gomodel:YEL058W-MONOMER_PHOSACETYLGLUCOSAMINEMUT-RXN_controller."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/22; endpoint types: /individuals/16/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-024_3473a0fe238f	gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN	BFO:0000050	GO:0006048	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN BFO:0000050 gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY/YeastPathways_UDPNAGSYN-YEAST-PWY."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/23; endpoint types: /individuals/14/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-025_1c3dfc9635a0	gomodel:GLUCOSAMINEPNACETYLTRANS-RXN	RO:0002413	gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:GLUCOSAMINEPNACETYLTRANS-RXN RO:0002413 gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/24; endpoint types: /individuals/13/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-026_d3696c80a954	gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN	RO:0002233	CHEBI:15784	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN RO:0002233 gomodel:CHEBI_57513_GLUCOSAMINEPNACETYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/25; endpoint types: /individuals/16/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-027_bceb2ec3d97c	gomodel:NAG1P-URIDYLTRANS-RXN	RO:0002234	CHEBI:29888	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:NAG1P-URIDYLTRANS-RXN RO:0002234 gomodel:CHEBI_29888_NAG1P-URIDYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/26; endpoint types: /individuals/15/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-028_401d6ab1b178	gomodel:NAG1P-URIDYLTRANS-RXN	RO:0002233	CHEBI:15713	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:NAG1P-URIDYLTRANS-RXN RO:0002233 gomodel:CHEBI_46398_NAG1P-URIDYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/27; endpoint types: /individuals/15/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-029_e8450b5c4968	gomodel:NAG1P-URIDYLTRANS-RXN	RO:0002233	CHEBI:16446	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:NAG1P-URIDYLTRANS-RXN RO:0002233 gomodel:CHEBI_57776_PHOSACETYLGLUCOSAMINEMUT-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/28; endpoint types: /individuals/15/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-030_4875dae44f38	gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN	RO:0002234	CHEBI:12962	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN RO:0002234 gomodel:CHEBI_15873_L-GLN-FRUCT-6-P-AMINOTRANS-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/29; endpoint types: /individuals/14/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_edge-031_c66d43c99a0b	gomodel:GLUCOSAMINEPNACETYLTRANS-RXN	RO:0002234	CHEBI:15346	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY		"[{""reference_id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_assertion"": ""The model asserts gomodel:GLUCOSAMINEPNACETYLTRANS-RXN RO:0002234 gomodel:CHEBI_57287_GLUCOSAMINEPNACETYLTRANS-RXN."", ""source_locator"": ""./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/30; endpoint types: /individuals/13/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json"", ""title"": ""GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_location-c688e51f158d_815ba9335b34	SGD:S000002261	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P43123	Physical protein location from reviewed UniProt. ECO:0000305	"[{""reference_id"": ""UniProtKB:P43123"", ""source_assertion"": ""UniProtKB:P43123 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1848/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P43123"", ""source_assertion"": ""UniProtKB:P43123 has the exact SGD cross-reference SGD:S000002261."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1848/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P43123"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P43123 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_location-1a4dd6333d5c_e29812f2fe70	SGD:S000000784	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38628	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38628"", ""source_assertion"": ""UniProtKB:P38628 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1398/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38628"", ""source_assertion"": ""UniProtKB:P38628 has the exact SGD cross-reference SGD:S000000784."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1398/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38628"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38628 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_location-1698701de7ff_97c63901375f	SGD:S000000784	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38628	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38628"", ""source_assertion"": ""UniProtKB:P38628 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1398/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38628"", ""source_assertion"": ""UniProtKB:P38628 has the exact SGD cross-reference SGD:S000000784."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1398/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38628"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38628 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_UDPNAGSYN-YEAST-PWY_cofactor-b878c0e5b209_a6250efcbe5e	SGD:S000000784	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38628	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q9P4V2) Binds 1 Mg(2+) ion per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:Q9P4V2)	"[{""reference_id"": ""UniProtKB:P38628"", ""source_assertion"": ""UniProtKB:P38628 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1398/comments/0/cofactors/0; /results/1398/comments/0/note""}, {""reference_id"": ""UniProtKB:P38628"", ""source_assertion"": ""UniProtKB:P38628 has the exact SGD cross-reference SGD:S000000784."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1398/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38628"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38628 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-001_db55e389d143	CHEBI:15377	pathwaymech:consumes	RHEA:18634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18634		"[{""reference_id"": ""RHEA:18634"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the substrates side of RHEA:18634 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18634']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18634"", ""source_version"": ""139"", ""title"": ""Rhea carbamoyl-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18634""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-002_e0a19a57421e	CHEBI:17544	pathwaymech:consumes	RHEA:18634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18634		"[{""reference_id"": ""RHEA:18634"", ""source_assertion"": ""Rhea lists CHEBI:17544 on the substrates side of RHEA:18634 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18634']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18634"", ""source_version"": ""139"", ""title"": ""Rhea carbamoyl-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18634""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-003_890a9f474495	CHEBI:30616	pathwaymech:consumes	RHEA:18634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18634		"[{""reference_id"": ""RHEA:18634"", ""source_assertion"": ""Rhea lists CHEBI:30616 on the substrates side of RHEA:18634 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18634']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18634"", ""source_version"": ""139"", ""title"": ""Rhea carbamoyl-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18634""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-004_1cbdb33ea6c0	CHEBI:58359	pathwaymech:consumes	RHEA:18634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18634		"[{""reference_id"": ""RHEA:18634"", ""source_assertion"": ""Rhea lists CHEBI:58359 on the substrates side of RHEA:18634 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18634']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18634"", ""source_version"": ""139"", ""title"": ""Rhea carbamoyl-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18634""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-005_55f0bf2f8875	RHEA:18634	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18634		"[{""reference_id"": ""RHEA:18634"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:18634 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18634']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18634"", ""source_version"": ""139"", ""title"": ""Rhea carbamoyl-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18634""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-006_85011905580d	RHEA:18634	pathwaymech:produces	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18634		"[{""reference_id"": ""RHEA:18634"", ""source_assertion"": ""Rhea lists CHEBI:29985 on the products side of RHEA:18634 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18634']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18634"", ""source_version"": ""139"", ""title"": ""Rhea carbamoyl-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18634""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-007_bd6e2a2bd331	RHEA:18634	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18634		"[{""reference_id"": ""RHEA:18634"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:18634 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18634']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18634"", ""source_version"": ""139"", ""title"": ""Rhea carbamoyl-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18634""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-008_559dbdf3509b	RHEA:18634	pathwaymech:produces	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18634		"[{""reference_id"": ""RHEA:18634"", ""source_assertion"": ""Rhea lists CHEBI:456216 on the products side of RHEA:18634 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18634']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18634"", ""source_version"": ""139"", ""title"": ""Rhea carbamoyl-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18634""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-009_2e48e6204a77	RHEA:18634	pathwaymech:produces	CHEBI:58228	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18634		"[{""reference_id"": ""RHEA:18634"", ""source_assertion"": ""Rhea lists CHEBI:58228 on the products side of RHEA:18634 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/18634']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:18634"", ""source_version"": ""139"", ""title"": ""Rhea carbamoyl-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/18634""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-010_3216a01fc142	CHEBI:29991	pathwaymech:consumes	RHEA:20014	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20014		"[{""reference_id"": ""RHEA:20014"", ""source_assertion"": ""Rhea lists CHEBI:29991 on the substrates side of RHEA:20014 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20014']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20014"", ""source_version"": ""139"", ""title"": ""Rhea N-carbamoyl-L-aspartate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/20014""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-011_5c00d05ab9a8	CHEBI:58228	pathwaymech:consumes	RHEA:20014	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20014		"[{""reference_id"": ""RHEA:20014"", ""source_assertion"": ""Rhea lists CHEBI:58228 on the substrates side of RHEA:20014 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20014']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20014"", ""source_version"": ""139"", ""title"": ""Rhea N-carbamoyl-L-aspartate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/20014""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-012_4adf95ea6067	RHEA:20014	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20014		"[{""reference_id"": ""RHEA:20014"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the products side of RHEA:20014 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20014']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20014"", ""source_version"": ""139"", ""title"": ""Rhea N-carbamoyl-L-aspartate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/20014""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-013_eae2a8e39703	RHEA:20014	pathwaymech:produces	CHEBI:32814	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20014		"[{""reference_id"": ""RHEA:20014"", ""source_assertion"": ""Rhea lists CHEBI:32814 on the products side of RHEA:20014 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20014']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20014"", ""source_version"": ""139"", ""title"": ""Rhea N-carbamoyl-L-aspartate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/20014""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-014_dbcb6564b5fa	RHEA:20014	pathwaymech:produces	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20014		"[{""reference_id"": ""RHEA:20014"", ""source_assertion"": ""Rhea lists CHEBI:43474 on the products side of RHEA:20014 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/20014']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:20014"", ""source_version"": ""139"", ""title"": ""Rhea N-carbamoyl-L-aspartate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/20014""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-015_9c0377949628	CHEBI:15378	pathwaymech:consumes	RHEA:24298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24298		"[{""reference_id"": ""RHEA:24298"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:24298 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24298']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24298"", ""source_version"": ""139"", ""title"": ""Rhea dihydroorotate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24298""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-016_8c5797afec10	CHEBI:32814	pathwaymech:consumes	RHEA:24298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24298		"[{""reference_id"": ""RHEA:24298"", ""source_assertion"": ""Rhea lists CHEBI:32814 on the substrates side of RHEA:24298 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24298']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24298"", ""source_version"": ""139"", ""title"": ""Rhea dihydroorotate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24298""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-017_70382b3f5195	RHEA:24298	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24298		"[{""reference_id"": ""RHEA:24298"", ""source_assertion"": ""Rhea lists CHEBI:15377 on the products side of RHEA:24298 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24298']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24298"", ""source_version"": ""139"", ""title"": ""Rhea dihydroorotate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24298""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-018_cc638016e943	RHEA:24298	pathwaymech:produces	CHEBI:30864	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24298		"[{""reference_id"": ""RHEA:24298"", ""source_assertion"": ""Rhea lists CHEBI:30864 on the products side of RHEA:24298 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/24298']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:24298"", ""source_version"": ""139"", ""title"": ""Rhea dihydroorotate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/24298""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-019_258c65ef8662	CHEBI:132124	pathwaymech:consumes	RHEA:30188	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30188		"[{""reference_id"": ""RHEA:30188"", ""source_assertion"": ""Rhea lists CHEBI:132124 on the substrates side of RHEA:30188 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30188']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:30188"", ""source_version"": ""139"", ""title"": ""Rhea orotate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/30188""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-020_9d53459729e4	CHEBI:30864	pathwaymech:consumes	RHEA:30188	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30188		"[{""reference_id"": ""RHEA:30188"", ""source_assertion"": ""Rhea lists CHEBI:30864 on the substrates side of RHEA:30188 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30188']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:30188"", ""source_version"": ""139"", ""title"": ""Rhea orotate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/30188""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-021_df2fbb7c674f	RHEA:30188	pathwaymech:produces	CHEBI:24646	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30188		"[{""reference_id"": ""RHEA:30188"", ""source_assertion"": ""Rhea lists CHEBI:24646 on the products side of RHEA:30188 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30188']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:30188"", ""source_version"": ""139"", ""title"": ""Rhea orotate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/30188""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-022_2d313823b80f	RHEA:30188	pathwaymech:produces	CHEBI:30839	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30188		"[{""reference_id"": ""RHEA:30188"", ""source_assertion"": ""Rhea lists CHEBI:30839 on the products side of RHEA:30188 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/30188']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:30188"", ""source_version"": ""139"", ""title"": ""Rhea orotate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/30188""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-023_cddc275dba4a	CHEBI:30839	pathwaymech:consumes	RHEA:10382	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10382		"[{""reference_id"": ""RHEA:10382"", ""source_assertion"": ""Rhea lists CHEBI:30839 on the substrates side of RHEA:10382 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10382']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10382"", ""source_version"": ""139"", ""title"": ""Rhea orotidine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10382""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-024_0a69d34a5f6d	CHEBI:58017	pathwaymech:consumes	RHEA:10382	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10382		"[{""reference_id"": ""RHEA:10382"", ""source_assertion"": ""Rhea lists CHEBI:58017 on the substrates side of RHEA:10382 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10382']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10382"", ""source_version"": ""139"", ""title"": ""Rhea orotidine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10382""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-025_c3bf9b51a95e	RHEA:10382	pathwaymech:produces	CHEBI:33019	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10382		"[{""reference_id"": ""RHEA:10382"", ""source_assertion"": ""Rhea lists CHEBI:33019 on the products side of RHEA:10382 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10382']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10382"", ""source_version"": ""139"", ""title"": ""Rhea orotidine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10382""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-026_39bd476f43c2	RHEA:10382	pathwaymech:produces	CHEBI:57538	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10382		"[{""reference_id"": ""RHEA:10382"", ""source_assertion"": ""Rhea lists CHEBI:57538 on the products side of RHEA:10382 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/10382']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:10382"", ""source_version"": ""139"", ""title"": ""Rhea orotidine 5'-phosphate-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/10382""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-027_de1abae62b5c	CHEBI:15378	pathwaymech:consumes	RHEA:11597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11597		"[{""reference_id"": ""RHEA:11597"", ""source_assertion"": ""Rhea lists CHEBI:15378 on the substrates side of RHEA:11597 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11597']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11597"", ""source_version"": ""139"", ""title"": ""Rhea UMP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/11597""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-028_1244820273c3	CHEBI:57538	pathwaymech:consumes	RHEA:11597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11597		"[{""reference_id"": ""RHEA:11597"", ""source_assertion"": ""Rhea lists CHEBI:57538 on the substrates side of RHEA:11597 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11597']/rh:substrates; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11597"", ""source_version"": ""139"", ""title"": ""Rhea UMP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/11597""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-029_2d32bade4a9c	RHEA:11597	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11597		"[{""reference_id"": ""RHEA:11597"", ""source_assertion"": ""Rhea lists CHEBI:16526 on the products side of RHEA:11597 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11597']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11597"", ""source_version"": ""139"", ""title"": ""Rhea UMP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/11597""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-030_630b5060f25d	RHEA:11597	pathwaymech:produces	CHEBI:57865	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11597		"[{""reference_id"": ""RHEA:11597"", ""source_assertion"": ""Rhea lists CHEBI:57865 on the products side of RHEA:11597 in this directed reaction."", ""source_locator"": ""rdf:Description[@rdf:about='http://rdf.rhea-db.org/11597']/rh:products; rh:contains/rh:compound/rh:accession""}]"	"[{""id"": ""RHEA:11597"", ""source_version"": ""139"", ""title"": ""Rhea UMP-forming direction"", ""url"": ""https://www.rhea-db.org/rhea/11597""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-031_37ca07f9c471	EC:6.3.5.5	pathwaymech:catalyzes	RHEA:18634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:18633		"[{""reference_id"": ""RHEA:18633"", ""source_assertion"": ""Rhea associates EC:6.3.5.5 with the reaction family containing RHEA:18634."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:18633"", ""source_version"": ""139"", ""title"": ""Rhea carbamoyl-phosphate synthase reaction"", ""url"": ""https://www.rhea-db.org/rhea/18633""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-032_8636aac301fc	EC:2.1.3.2	pathwaymech:catalyzes	RHEA:20014	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:20013		"[{""reference_id"": ""RHEA:20013"", ""source_assertion"": ""Rhea associates EC:2.1.3.2 with the reaction family containing RHEA:20014."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:20013"", ""source_version"": ""139"", ""title"": ""Rhea aspartate carbamoyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/20013""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-033_42a767de8b0d	EC:3.5.2.3	pathwaymech:catalyzes	RHEA:24298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:24296		"[{""reference_id"": ""RHEA:24296"", ""source_assertion"": ""Rhea associates EC:3.5.2.3 with the reaction family containing RHEA:24298."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:24296"", ""source_version"": ""139"", ""title"": ""Rhea dihydroorotase reaction"", ""url"": ""https://www.rhea-db.org/rhea/24296""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-034_4d2cd4dce50e	EC:1.3.5.2	pathwaymech:catalyzes	RHEA:30188	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:30187		"[{""reference_id"": ""RHEA:30187"", ""source_assertion"": ""Rhea associates EC:1.3.5.2 with the reaction family containing RHEA:30188."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:30187"", ""source_version"": ""139"", ""title"": ""Rhea dihydroorotate dehydrogenase quinone reaction"", ""url"": ""https://www.rhea-db.org/rhea/30187""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-035_f71283cf4766	EC:2.4.2.10	pathwaymech:catalyzes	RHEA:10382	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:10380		"[{""reference_id"": ""RHEA:10380"", ""source_assertion"": ""Rhea associates EC:2.4.2.10 with the reaction family containing RHEA:10382."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:10380"", ""source_version"": ""139"", ""title"": ""Rhea orotate phosphoribosyltransferase reaction"", ""url"": ""https://www.rhea-db.org/rhea/10380""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-036_bf4b60f4bb52	EC:4.1.1.23	pathwaymech:catalyzes	RHEA:11597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:11596		"[{""reference_id"": ""RHEA:11596"", ""source_assertion"": ""Rhea associates EC:4.1.1.23 with the reaction family containing RHEA:11597."", ""source_locator"": ""rh:ec""}]"	"[{""id"": ""RHEA:11596"", ""source_version"": ""139"", ""title"": ""Rhea orotidine-5'-phosphate decarboxylase reaction"", ""url"": ""https://www.rhea-db.org/rhea/11596""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-037_8bec66547bf9	RHEA:10382	pathwaymech:precedes	RHEA:11597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5686		"[{""reference_id"": ""MetaCyc:PWY-5686"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:10382 before RHEA:11597 in this pathway. Shared intermediate: CHEBI:57538."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-5686"", ""source_sha256"": ""90cae5adced3ec84117dc6c9f3f1be06cdc5c86977e4430887593f183040f51c"", ""source_version"": ""22.5"", ""title"": ""MetaCyc UMP biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-5686&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-038_50e4e34e85d9	RHEA:18634	pathwaymech:precedes	RHEA:20014	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5686		"[{""reference_id"": ""MetaCyc:PWY-5686"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:18634 before RHEA:20014 in this pathway. Shared intermediate: CHEBI:58228."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-5686"", ""source_sha256"": ""90cae5adced3ec84117dc6c9f3f1be06cdc5c86977e4430887593f183040f51c"", ""source_version"": ""22.5"", ""title"": ""MetaCyc UMP biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-5686&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-039_38e1bf67c5c5	RHEA:20014	pathwaymech:precedes	RHEA:24298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5686		"[{""reference_id"": ""MetaCyc:PWY-5686"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:20014 before RHEA:24298 in this pathway. Shared intermediate: CHEBI:32814."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-5686"", ""source_sha256"": ""90cae5adced3ec84117dc6c9f3f1be06cdc5c86977e4430887593f183040f51c"", ""source_version"": ""22.5"", ""title"": ""MetaCyc UMP biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-5686&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-040_e9007707fcb7	RHEA:24298	pathwaymech:precedes	RHEA:30188	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5686		"[{""reference_id"": ""MetaCyc:PWY-5686"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:24298 before RHEA:30188 in this pathway. Shared intermediate: CHEBI:30864."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-5686"", ""source_sha256"": ""90cae5adced3ec84117dc6c9f3f1be06cdc5c86977e4430887593f183040f51c"", ""source_version"": ""22.5"", ""title"": ""MetaCyc UMP biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-5686&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-041_d1202f0ccb92	RHEA:30188	pathwaymech:precedes	RHEA:10382	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:PWY-5686		"[{""reference_id"": ""MetaCyc:PWY-5686"", ""source_assertion"": ""MetaCyc pathway ordering places RHEA:30188 before RHEA:10382 in this pathway. Shared intermediate: CHEBI:30839."", ""source_locator"": ""Pathway/reaction-ordering and reaction-layout; Rhea-to-MetaCyc cross-references""}]"	"[{""id"": ""MetaCyc:PWY-5686"", ""source_sha256"": ""90cae5adced3ec84117dc6c9f3f1be06cdc5c86977e4430887593f183040f51c"", ""source_version"": ""22.5"", ""title"": ""MetaCyc UMP biosynthesis I pathway"", ""url"": ""https://pathway.yeastgenome.org/getxml?id=META:PWY-5686&detail=full""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-042_8fcde4d562c6	UniProtKB:P00968	pathwaymech:enables	RHEA:18634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00968		"[{""reference_id"": ""UniProtKB:P00968"", ""source_assertion"": ""UniProt annotates UniProtKB:P00968 with catalytic activity for the reaction family of RHEA:18634. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P00968"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00968 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00968.json""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-043_0cbf49909985	UniProtKB:P00968	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00968		"[{""reference_id"": ""UniProtKB:P00968"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P00968 (evidence: ECO:0000255). Binds 4 Mg(2+) or Mn(2+) ions per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P00968"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00968 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00968.json""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-044_099fe2cc1fa8	UniProtKB:P00968	pathwaymech:has_cofactor	CHEBI:29035	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00968		"[{""reference_id"": ""UniProtKB:P00968"", ""source_assertion"": ""UniProt lists CHEBI:29035 as a cofactor of UniProtKB:P00968 (evidence: ECO:0000255, ECO:0000269). Binds 4 Mg(2+) or Mn(2+) ions per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P00968"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P00968 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P00968.json""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-045_4d2c625c6a77	UniProtKB:P05020	pathwaymech:enables	RHEA:24298	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05020		"[{""reference_id"": ""UniProtKB:P05020"", ""source_assertion"": ""UniProt annotates UniProtKB:P05020 with catalytic activity for the reaction family of RHEA:24298. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P05020"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05020 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05020.json""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-046_50feb37f0d71	UniProtKB:P05020	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P05020		"[{""reference_id"": ""UniProtKB:P05020"", ""source_assertion"": ""UniProt lists CHEBI:29105 as a cofactor of UniProtKB:P05020 (evidence: ECO:0000255, ECO:0000269). Binds 2 Zn(2+) ions per subunit (PubMed:11401542, PubMed:15826651, PubMed:6142052). In vitro, can also use Co(2+) or Cd(2+) (PubMed:15610022, PubMed:1671037)."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P05020"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P05020 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P05020.json""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-047_d6c9cb1d0a5a	UniProtKB:P08244	pathwaymech:enables	RHEA:11597	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P08244		"[{""reference_id"": ""UniProtKB:P08244"", ""source_assertion"": ""UniProt annotates UniProtKB:P08244 with catalytic activity for the reaction family of RHEA:11597. Annotation evidence: curated source annotation; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P08244"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P08244 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P08244.json""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-048_8f595de06fcd	UniProtKB:P0A6F1	pathwaymech:enables	RHEA:18634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A6F1		"[{""reference_id"": ""UniProtKB:P0A6F1"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A6F1 with catalytic activity for the reaction family of RHEA:18634. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A6F1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A6F1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A6F1.json""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-049_4381b8b129ed	UniProtKB:P0A786	pathwaymech:enables	RHEA:20014	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A786		"[{""reference_id"": ""UniProtKB:P0A786"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A786 with catalytic activity for the reaction family of RHEA:20014. Annotation evidence: ECO:0000255, ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A786"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A786 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A786.json""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-050_2b07bf0b4b1b	UniProtKB:P0A7E1	pathwaymech:enables	RHEA:30188	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A7E1		"[{""reference_id"": ""UniProtKB:P0A7E1"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A7E1 with catalytic activity for the reaction family of RHEA:30188. Annotation evidence: ECO:0000269; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A7E1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A7E1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A7E1.json""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-051_32411bb6fb77	UniProtKB:P0A7E1	RO:0001025	GO:0005886	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A7E1		"[{""reference_id"": ""UniProtKB:P0A7E1"", ""source_assertion"": ""UniProt locates UniProtKB:P0A7E1 in Cell membrane (SL-0039, mapped by UniProt to GO:0005886). Annotation evidence: curated source annotation."", ""source_locator"": ""comments[commentType='SUBCELLULAR LOCATION'].subcellularLocations; UniProt location vocabulary GO mapping""}]"	"[{""id"": ""UniProtKB:P0A7E1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A7E1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A7E1.json""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-052_9c7d6a4675e7	UniProtKB:P0A7E1	pathwaymech:has_cofactor	CHEBI:58210	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A7E1		"[{""reference_id"": ""UniProtKB:P0A7E1"", ""source_assertion"": ""UniProt lists CHEBI:58210 as a cofactor of UniProtKB:P0A7E1 (evidence: ECO:0000269). Binds 1 FMN per subunit."", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0A7E1"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A7E1 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A7E1.json""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-053_58dfc701398f	UniProtKB:P0A7E3	pathwaymech:enables	RHEA:10382	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A7E3		"[{""reference_id"": ""UniProtKB:P0A7E3"", ""source_assertion"": ""UniProt annotates UniProtKB:P0A7E3 with catalytic activity for the reaction family of RHEA:10382. Annotation evidence: ECO:0000255; organism taxon: NCBITaxon:83333."", ""source_locator"": ""comments[commentType='CATALYTIC ACTIVITY'].reaction.reactionCrossReferences""}]"	"[{""id"": ""UniProtKB:P0A7E3"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A7E3 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A7E3.json""}]"	""
pathwaymech:MetaCyc_PWY-5686_edge-054_068a723686f3	UniProtKB:P0A7E3	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P0A7E3		"[{""reference_id"": ""UniProtKB:P0A7E3"", ""source_assertion"": ""UniProt lists CHEBI:18420 as a cofactor of UniProtKB:P0A7E3 (evidence: ECO:0000255). "", ""source_locator"": ""comments[commentType='COFACTOR'].cofactors and note""}]"	"[{""id"": ""UniProtKB:P0A7E3"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB:P0A7E3 authority record"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0A7E3.json""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-001_c6e485b2faa5	CHEBI:58210	pathwaymech:consumes	RHEA:21622	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21622		"[{""reference_id"": ""RHEA:21622"", ""source_assertion"": ""Rhea RHEA:21622 places CHEBI:58210 on its substrates side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/21622 rh:substrates http://rdf.rhea-db.org/21620_R; http://rdf.rhea-db.org/21620_R rh:contains1 http://rdf.rhea-db.org/Participant_21620_compound_2613; http://rdf.rhea-db.org/Participant_21620_compound_2613 rh:compound http://rdf.rhea-db.org/Compound_2613; http://rdf.rhea-db.org/Compound_2613 rh:chebi""}]"	"[{""id"": ""RHEA:21622"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""FMN + NADH + 2 H(+) => FMNH2 + NAD(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-002_73363dca9f6d	CHEBI:57945	pathwaymech:consumes	RHEA:21622	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21622		"[{""reference_id"": ""RHEA:21622"", ""source_assertion"": ""Rhea RHEA:21622 places CHEBI:57945 on its substrates side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/21622 rh:substrates http://rdf.rhea-db.org/21620_R; http://rdf.rhea-db.org/21620_R rh:contains1 http://rdf.rhea-db.org/Participant_21620_compound_1650; http://rdf.rhea-db.org/Participant_21620_compound_1650 rh:compound http://rdf.rhea-db.org/Compound_1650; http://rdf.rhea-db.org/Compound_1650 rh:chebi""}]"	"[{""id"": ""RHEA:21622"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""FMN + NADH + 2 H(+) => FMNH2 + NAD(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-003_f06485489c01	CHEBI:15378	pathwaymech:consumes	RHEA:21622	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21622		"[{""reference_id"": ""RHEA:21622"", ""source_assertion"": ""Rhea RHEA:21622 places CHEBI:15378 on its substrates side with stoichiometric coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/21622 rh:substrates http://rdf.rhea-db.org/21620_R; http://rdf.rhea-db.org/21620_R rh:contains2 http://rdf.rhea-db.org/Participant_21620_compound_3249; http://rdf.rhea-db.org/Participant_21620_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; http://rdf.rhea-db.org/Compound_3249 rh:chebi""}]"	"[{""id"": ""RHEA:21622"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""FMN + NADH + 2 H(+) => FMNH2 + NAD(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-004_00e0e7322388	RHEA:21622	pathwaymech:produces	CHEBI:57618	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21622		"[{""reference_id"": ""RHEA:21622"", ""source_assertion"": ""Rhea RHEA:21622 places CHEBI:57618 on its products side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/21622 rh:products http://rdf.rhea-db.org/21620_L; http://rdf.rhea-db.org/21620_L rh:contains1 http://rdf.rhea-db.org/Participant_21620_compound_1829; http://rdf.rhea-db.org/Participant_21620_compound_1829 rh:compound http://rdf.rhea-db.org/Compound_1829; http://rdf.rhea-db.org/Compound_1829 rh:chebi""}]"	"[{""id"": ""RHEA:21622"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""FMN + NADH + 2 H(+) => FMNH2 + NAD(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-005_6472fc2996a7	RHEA:21622	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:21622		"[{""reference_id"": ""RHEA:21622"", ""source_assertion"": ""Rhea RHEA:21622 places CHEBI:57540 on its products side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/21622 rh:products http://rdf.rhea-db.org/21620_L; http://rdf.rhea-db.org/21620_L rh:contains1 http://rdf.rhea-db.org/Participant_21620_compound_3484; http://rdf.rhea-db.org/Participant_21620_compound_3484 rh:compound http://rdf.rhea-db.org/Compound_3484; http://rdf.rhea-db.org/Compound_3484 rh:chebi""}]"	"[{""id"": ""RHEA:21622"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""FMN + NADH + 2 H(+) => FMNH2 + NAD(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-006_0114d167886e	CHEBI:17568	pathwaymech:consumes	RHEA:31588	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31588		"[{""reference_id"": ""RHEA:31588"", ""source_assertion"": ""Rhea RHEA:31588 places CHEBI:17568 on its substrates side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31588 rh:substrates http://rdf.rhea-db.org/31587_L; http://rdf.rhea-db.org/31587_L rh:contains1 http://rdf.rhea-db.org/Participant_31587_compound_4063; http://rdf.rhea-db.org/Participant_31587_compound_4063 rh:compound http://rdf.rhea-db.org/Compound_4063; http://rdf.rhea-db.org/Compound_4063 rh:chebi""}]"	"[{""id"": ""RHEA:31588"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""uracil + FMNH2 + NADH + O2 => (Z)-3-ureidoacrylate + FMN + NAD(+) + H2O + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-007_452eee27caab	CHEBI:57618	pathwaymech:consumes	RHEA:31588	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31588		"[{""reference_id"": ""RHEA:31588"", ""source_assertion"": ""Rhea RHEA:31588 places CHEBI:57618 on its substrates side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31588 rh:substrates http://rdf.rhea-db.org/31587_L; http://rdf.rhea-db.org/31587_L rh:contains1 http://rdf.rhea-db.org/Participant_31587_compound_1829; http://rdf.rhea-db.org/Participant_31587_compound_1829 rh:compound http://rdf.rhea-db.org/Compound_1829; http://rdf.rhea-db.org/Compound_1829 rh:chebi""}]"	"[{""id"": ""RHEA:31588"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""uracil + FMNH2 + NADH + O2 => (Z)-3-ureidoacrylate + FMN + NAD(+) + H2O + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-008_c48a11a3f9f8	CHEBI:57945	pathwaymech:consumes	RHEA:31588	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31588		"[{""reference_id"": ""RHEA:31588"", ""source_assertion"": ""Rhea RHEA:31588 places CHEBI:57945 on its substrates side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31588 rh:substrates http://rdf.rhea-db.org/31587_L; http://rdf.rhea-db.org/31587_L rh:contains1 http://rdf.rhea-db.org/Participant_31587_compound_1650; http://rdf.rhea-db.org/Participant_31587_compound_1650 rh:compound http://rdf.rhea-db.org/Compound_1650; http://rdf.rhea-db.org/Compound_1650 rh:chebi""}]"	"[{""id"": ""RHEA:31588"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""uracil + FMNH2 + NADH + O2 => (Z)-3-ureidoacrylate + FMN + NAD(+) + H2O + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-009_527cc4d1ebd7	CHEBI:15379	pathwaymech:consumes	RHEA:31588	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31588		"[{""reference_id"": ""RHEA:31588"", ""source_assertion"": ""Rhea RHEA:31588 places CHEBI:15379 on its substrates side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31588 rh:substrates http://rdf.rhea-db.org/31587_L; http://rdf.rhea-db.org/31587_L rh:contains1 http://rdf.rhea-db.org/Participant_31587_compound_1198; http://rdf.rhea-db.org/Participant_31587_compound_1198 rh:compound http://rdf.rhea-db.org/Compound_1198; http://rdf.rhea-db.org/Compound_1198 rh:chebi""}]"	"[{""id"": ""RHEA:31588"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""uracil + FMNH2 + NADH + O2 => (Z)-3-ureidoacrylate + FMN + NAD(+) + H2O + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-010_8a0a7e15cf7a	RHEA:31588	pathwaymech:produces	CHEBI:59891	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31588		"[{""reference_id"": ""RHEA:31588"", ""source_assertion"": ""Rhea RHEA:31588 places CHEBI:59891 on its products side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31588 rh:products http://rdf.rhea-db.org/31587_R; http://rdf.rhea-db.org/31587_R rh:contains1 http://rdf.rhea-db.org/Participant_31587_compound_6882; http://rdf.rhea-db.org/Participant_31587_compound_6882 rh:compound http://rdf.rhea-db.org/Compound_6882; http://rdf.rhea-db.org/Compound_6882 rh:chebi""}]"	"[{""id"": ""RHEA:31588"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""uracil + FMNH2 + NADH + O2 => (Z)-3-ureidoacrylate + FMN + NAD(+) + H2O + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-011_bb4d275876ec	RHEA:31588	pathwaymech:produces	CHEBI:58210	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31588		"[{""reference_id"": ""RHEA:31588"", ""source_assertion"": ""Rhea RHEA:31588 places CHEBI:58210 on its products side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31588 rh:products http://rdf.rhea-db.org/31587_R; http://rdf.rhea-db.org/31587_R rh:contains1 http://rdf.rhea-db.org/Participant_31587_compound_2613; http://rdf.rhea-db.org/Participant_31587_compound_2613 rh:compound http://rdf.rhea-db.org/Compound_2613; http://rdf.rhea-db.org/Compound_2613 rh:chebi""}]"	"[{""id"": ""RHEA:31588"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""uracil + FMNH2 + NADH + O2 => (Z)-3-ureidoacrylate + FMN + NAD(+) + H2O + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-012_226176b38145	RHEA:31588	pathwaymech:produces	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31588		"[{""reference_id"": ""RHEA:31588"", ""source_assertion"": ""Rhea RHEA:31588 places CHEBI:57540 on its products side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31588 rh:products http://rdf.rhea-db.org/31587_R; http://rdf.rhea-db.org/31587_R rh:contains1 http://rdf.rhea-db.org/Participant_31587_compound_3484; http://rdf.rhea-db.org/Participant_31587_compound_3484 rh:compound http://rdf.rhea-db.org/Compound_3484; http://rdf.rhea-db.org/Compound_3484 rh:chebi""}]"	"[{""id"": ""RHEA:31588"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""uracil + FMNH2 + NADH + O2 => (Z)-3-ureidoacrylate + FMN + NAD(+) + H2O + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-013_9925ceeadf60	RHEA:31588	pathwaymech:produces	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31588		"[{""reference_id"": ""RHEA:31588"", ""source_assertion"": ""Rhea RHEA:31588 places CHEBI:15377 on its products side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31588 rh:products http://rdf.rhea-db.org/31587_R; http://rdf.rhea-db.org/31587_R rh:contains1 http://rdf.rhea-db.org/Participant_31587_compound_1283; http://rdf.rhea-db.org/Participant_31587_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; http://rdf.rhea-db.org/Compound_1283 rh:chebi""}]"	"[{""id"": ""RHEA:31588"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""uracil + FMNH2 + NADH + O2 => (Z)-3-ureidoacrylate + FMN + NAD(+) + H2O + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-014_a4a61186b2eb	RHEA:31588	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31588		"[{""reference_id"": ""RHEA:31588"", ""source_assertion"": ""Rhea RHEA:31588 places CHEBI:15378 on its products side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31588 rh:products http://rdf.rhea-db.org/31587_R; http://rdf.rhea-db.org/31587_R rh:contains1 http://rdf.rhea-db.org/Participant_31587_compound_3249; http://rdf.rhea-db.org/Participant_31587_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; http://rdf.rhea-db.org/Compound_3249 rh:chebi""}]"	"[{""id"": ""RHEA:31588"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""uracil + FMNH2 + NADH + O2 => (Z)-3-ureidoacrylate + FMN + NAD(+) + H2O + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-015_452753a7507d	CHEBI:59891	pathwaymech:consumes	RHEA:31604	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31604		"[{""reference_id"": ""RHEA:31604"", ""source_assertion"": ""Rhea RHEA:31604 places CHEBI:59891 on its substrates side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31604 rh:substrates http://rdf.rhea-db.org/31603_L; http://rdf.rhea-db.org/31603_L rh:contains1 http://rdf.rhea-db.org/Participant_31603_compound_6882; http://rdf.rhea-db.org/Participant_31603_compound_6882 rh:compound http://rdf.rhea-db.org/Compound_6882; http://rdf.rhea-db.org/Compound_6882 rh:chebi""}]"	"[{""id"": ""RHEA:31604"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-ureidoacrylate + H2O => (Z)-3-aminoacrylate + carbamate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-016_96bfee722b73	CHEBI:15377	pathwaymech:consumes	RHEA:31604	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31604		"[{""reference_id"": ""RHEA:31604"", ""source_assertion"": ""Rhea RHEA:31604 places CHEBI:15377 on its substrates side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31604 rh:substrates http://rdf.rhea-db.org/31603_L; http://rdf.rhea-db.org/31603_L rh:contains1 http://rdf.rhea-db.org/Participant_31603_compound_1283; http://rdf.rhea-db.org/Participant_31603_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; http://rdf.rhea-db.org/Compound_1283 rh:chebi""}]"	"[{""id"": ""RHEA:31604"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-ureidoacrylate + H2O => (Z)-3-aminoacrylate + carbamate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-017_f4cf93183226	RHEA:31604	pathwaymech:produces	CHEBI:59894	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31604		"[{""reference_id"": ""RHEA:31604"", ""source_assertion"": ""Rhea RHEA:31604 places CHEBI:59894 on its products side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31604 rh:products http://rdf.rhea-db.org/31603_R; http://rdf.rhea-db.org/31603_R rh:contains1 http://rdf.rhea-db.org/Participant_31603_compound_6886; http://rdf.rhea-db.org/Participant_31603_compound_6886 rh:compound http://rdf.rhea-db.org/Compound_6886; http://rdf.rhea-db.org/Compound_6886 rh:chebi""}]"	"[{""id"": ""RHEA:31604"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-ureidoacrylate + H2O => (Z)-3-aminoacrylate + carbamate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-018_ba9444e8e409	RHEA:31604	pathwaymech:produces	CHEBI:13941	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31604		"[{""reference_id"": ""RHEA:31604"", ""source_assertion"": ""Rhea RHEA:31604 places CHEBI:13941 on its products side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31604 rh:products http://rdf.rhea-db.org/31603_R; http://rdf.rhea-db.org/31603_R rh:contains1 http://rdf.rhea-db.org/Participant_31603_compound_4239; http://rdf.rhea-db.org/Participant_31603_compound_4239 rh:compound http://rdf.rhea-db.org/Compound_4239; http://rdf.rhea-db.org/Compound_4239 rh:chebi""}]"	"[{""id"": ""RHEA:31604"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-ureidoacrylate + H2O => (Z)-3-aminoacrylate + carbamate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-019_4318315f1425	RHEA:31604	pathwaymech:produces	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:31604		"[{""reference_id"": ""RHEA:31604"", ""source_assertion"": ""Rhea RHEA:31604 places CHEBI:15378 on its products side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/31604 rh:products http://rdf.rhea-db.org/31603_R; http://rdf.rhea-db.org/31603_R rh:contains1 http://rdf.rhea-db.org/Participant_31603_compound_3249; http://rdf.rhea-db.org/Participant_31603_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; http://rdf.rhea-db.org/Compound_3249 rh:chebi""}]"	"[{""id"": ""RHEA:31604"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-ureidoacrylate + H2O => (Z)-3-aminoacrylate + carbamate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-020_99bec5517f90	CHEBI:13941	pathwaymech:consumes	RHEA:15650	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN0-5222|RHEA:15650		"[{""reference_id"": ""RHEA:15650"", ""source_assertion"": ""Rhea RHEA:15650 places CHEBI:13941 on its substrates side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/15650 rh:substrates http://rdf.rhea-db.org/15649_L; http://rdf.rhea-db.org/15649_L rh:contains1 http://rdf.rhea-db.org/Participant_15649_compound_4239; http://rdf.rhea-db.org/Participant_15649_compound_4239 rh:compound http://rdf.rhea-db.org/Compound_4239; http://rdf.rhea-db.org/Compound_4239 rh:chebi""}, {""reference_id"": ""MetaCyc:RXN0-5222"", ""source_assertion"": ""The native reaction explicitly sets spontaneous=true for carbamate decomposition to ammonium and carbon dioxide."", ""source_locator"": ""Reaction[@frameid='RXN0-5222']/spontaneous; left; right""}]"	"[{""id"": ""MetaCyc:RXN0-5222"", ""source_sha256"": ""079f6290beaaa757c83d0ef8fdf3e0eeef3ed2c02cd9aa37f8e469e068b21d36"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""spontaneous carbamate decomposition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5222""}, {""id"": ""RHEA:15650"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""carbamate + 2 H(+) => NH4(+) + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-021_d60cc937ede4	CHEBI:15378	pathwaymech:consumes	RHEA:15650	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN0-5222|RHEA:15650		"[{""reference_id"": ""RHEA:15650"", ""source_assertion"": ""Rhea RHEA:15650 places CHEBI:15378 on its substrates side with stoichiometric coefficient 2."", ""source_locator"": ""http://rdf.rhea-db.org/15650 rh:substrates http://rdf.rhea-db.org/15649_L; http://rdf.rhea-db.org/15649_L rh:contains2 http://rdf.rhea-db.org/Participant_15649_compound_3249; http://rdf.rhea-db.org/Participant_15649_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; http://rdf.rhea-db.org/Compound_3249 rh:chebi""}, {""reference_id"": ""MetaCyc:RXN0-5222"", ""source_assertion"": ""The native reaction explicitly sets spontaneous=true for carbamate decomposition to ammonium and carbon dioxide."", ""source_locator"": ""Reaction[@frameid='RXN0-5222']/spontaneous; left; right""}]"	"[{""id"": ""MetaCyc:RXN0-5222"", ""source_sha256"": ""079f6290beaaa757c83d0ef8fdf3e0eeef3ed2c02cd9aa37f8e469e068b21d36"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""spontaneous carbamate decomposition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5222""}, {""id"": ""RHEA:15650"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""carbamate + 2 H(+) => NH4(+) + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-022_8f6ec5bea060	RHEA:15650	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN0-5222|RHEA:15650		"[{""reference_id"": ""RHEA:15650"", ""source_assertion"": ""Rhea RHEA:15650 places CHEBI:28938 on its products side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/15650 rh:products http://rdf.rhea-db.org/15649_R; http://rdf.rhea-db.org/15649_R rh:contains1 http://rdf.rhea-db.org/Participant_15649_compound_1012; http://rdf.rhea-db.org/Participant_15649_compound_1012 rh:compound http://rdf.rhea-db.org/Compound_1012; http://rdf.rhea-db.org/Compound_1012 rh:chebi""}, {""reference_id"": ""MetaCyc:RXN0-5222"", ""source_assertion"": ""The native reaction explicitly sets spontaneous=true for carbamate decomposition to ammonium and carbon dioxide."", ""source_locator"": ""Reaction[@frameid='RXN0-5222']/spontaneous; left; right""}]"	"[{""id"": ""MetaCyc:RXN0-5222"", ""source_sha256"": ""079f6290beaaa757c83d0ef8fdf3e0eeef3ed2c02cd9aa37f8e469e068b21d36"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""spontaneous carbamate decomposition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5222""}, {""id"": ""RHEA:15650"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""carbamate + 2 H(+) => NH4(+) + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-023_7812c4f1015f	RHEA:15650	pathwaymech:produces	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:RXN0-5222|RHEA:15650		"[{""reference_id"": ""RHEA:15650"", ""source_assertion"": ""Rhea RHEA:15650 places CHEBI:16526 on its products side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/15650 rh:products http://rdf.rhea-db.org/15649_R; http://rdf.rhea-db.org/15649_R rh:contains1 http://rdf.rhea-db.org/Participant_15649_compound_4391; http://rdf.rhea-db.org/Participant_15649_compound_4391 rh:compound http://rdf.rhea-db.org/Compound_4391; http://rdf.rhea-db.org/Compound_4391 rh:chebi""}, {""reference_id"": ""MetaCyc:RXN0-5222"", ""source_assertion"": ""The native reaction explicitly sets spontaneous=true for carbamate decomposition to ammonium and carbon dioxide."", ""source_locator"": ""Reaction[@frameid='RXN0-5222']/spontaneous; left; right""}]"	"[{""id"": ""MetaCyc:RXN0-5222"", ""source_sha256"": ""079f6290beaaa757c83d0ef8fdf3e0eeef3ed2c02cd9aa37f8e469e068b21d36"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""spontaneous carbamate decomposition"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:RXN0-5222""}, {""id"": ""RHEA:15650"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""carbamate + 2 H(+) => NH4(+) + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-024_0f505bddf6e7	CHEBI:59894	pathwaymech:consumes	RHEA:34948	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34948		"[{""reference_id"": ""RHEA:34948"", ""source_assertion"": ""Rhea RHEA:34948 places CHEBI:59894 on its substrates side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/34948 rh:substrates http://rdf.rhea-db.org/34947_L; http://rdf.rhea-db.org/34947_L rh:contains1 http://rdf.rhea-db.org/Participant_34947_compound_6886; http://rdf.rhea-db.org/Participant_34947_compound_6886 rh:compound http://rdf.rhea-db.org/Compound_6886; http://rdf.rhea-db.org/Compound_6886 rh:chebi""}]"	"[{""id"": ""RHEA:34948"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-aminoacrylate + H2O + H(+) => 3-oxopropanoate + NH4(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-025_9e4dc1c5f498	CHEBI:15377	pathwaymech:consumes	RHEA:34948	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34948		"[{""reference_id"": ""RHEA:34948"", ""source_assertion"": ""Rhea RHEA:34948 places CHEBI:15377 on its substrates side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/34948 rh:substrates http://rdf.rhea-db.org/34947_L; http://rdf.rhea-db.org/34947_L rh:contains1 http://rdf.rhea-db.org/Participant_34947_compound_1283; http://rdf.rhea-db.org/Participant_34947_compound_1283 rh:compound http://rdf.rhea-db.org/Compound_1283; http://rdf.rhea-db.org/Compound_1283 rh:chebi""}]"	"[{""id"": ""RHEA:34948"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-aminoacrylate + H2O + H(+) => 3-oxopropanoate + NH4(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-026_43945c34195e	CHEBI:15378	pathwaymech:consumes	RHEA:34948	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34948		"[{""reference_id"": ""RHEA:34948"", ""source_assertion"": ""Rhea RHEA:34948 places CHEBI:15378 on its substrates side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/34948 rh:substrates http://rdf.rhea-db.org/34947_L; http://rdf.rhea-db.org/34947_L rh:contains1 http://rdf.rhea-db.org/Participant_34947_compound_3249; http://rdf.rhea-db.org/Participant_34947_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; http://rdf.rhea-db.org/Compound_3249 rh:chebi""}]"	"[{""id"": ""RHEA:34948"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-aminoacrylate + H2O + H(+) => 3-oxopropanoate + NH4(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-027_d7cc3b396f7b	RHEA:34948	pathwaymech:produces	CHEBI:33190	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34948		"[{""reference_id"": ""RHEA:34948"", ""source_assertion"": ""Rhea RHEA:34948 places CHEBI:33190 on its products side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/34948 rh:products http://rdf.rhea-db.org/34947_R; http://rdf.rhea-db.org/34947_R rh:contains1 http://rdf.rhea-db.org/Participant_34947_compound_5274; http://rdf.rhea-db.org/Participant_34947_compound_5274 rh:compound http://rdf.rhea-db.org/Compound_5274; http://rdf.rhea-db.org/Compound_5274 rh:chebi""}]"	"[{""id"": ""RHEA:34948"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-aminoacrylate + H2O + H(+) => 3-oxopropanoate + NH4(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-028_fcda03528505	RHEA:34948	pathwaymech:produces	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:34948		"[{""reference_id"": ""RHEA:34948"", ""source_assertion"": ""Rhea RHEA:34948 places CHEBI:28938 on its products side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/34948 rh:products http://rdf.rhea-db.org/34947_R; http://rdf.rhea-db.org/34947_R rh:contains1 http://rdf.rhea-db.org/Participant_34947_compound_1012; http://rdf.rhea-db.org/Participant_34947_compound_1012 rh:compound http://rdf.rhea-db.org/Compound_1012; http://rdf.rhea-db.org/Compound_1012 rh:chebi""}]"	"[{""id"": ""RHEA:34948"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-aminoacrylate + H2O + H(+) => 3-oxopropanoate + NH4(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-029_7eced4efc339	CHEBI:33190	pathwaymech:consumes	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440		"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea RHEA:26440 places CHEBI:33190 on its substrates side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:substrates http://rdf.rhea-db.org/26438_R; http://rdf.rhea-db.org/26438_R rh:contains1 http://rdf.rhea-db.org/Participant_26438_compound_5274; http://rdf.rhea-db.org/Participant_26438_compound_5274 rh:compound http://rdf.rhea-db.org/Compound_5274; http://rdf.rhea-db.org/Compound_5274 rh:chebi""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-030_c6d8477eb347	CHEBI:57783	pathwaymech:consumes	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440		"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea RHEA:26440 places CHEBI:57783 on its substrates side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:substrates http://rdf.rhea-db.org/26438_R; http://rdf.rhea-db.org/26438_R rh:contains1 http://rdf.rhea-db.org/Participant_26438_compound_3438; http://rdf.rhea-db.org/Participant_26438_compound_3438 rh:compound http://rdf.rhea-db.org/Compound_3438; http://rdf.rhea-db.org/Compound_3438 rh:chebi""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-031_ca966c03add8	CHEBI:15378	pathwaymech:consumes	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440		"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea RHEA:26440 places CHEBI:15378 on its substrates side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:substrates http://rdf.rhea-db.org/26438_R; http://rdf.rhea-db.org/26438_R rh:contains1 http://rdf.rhea-db.org/Participant_26438_compound_3249; http://rdf.rhea-db.org/Participant_26438_compound_3249 rh:compound http://rdf.rhea-db.org/Compound_3249; http://rdf.rhea-db.org/Compound_3249 rh:chebi""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-032_cbf9432ce1e3	RHEA:26440	pathwaymech:produces	CHEBI:16510	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440		"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea RHEA:26440 places CHEBI:16510 on its products side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:products http://rdf.rhea-db.org/26438_L; http://rdf.rhea-db.org/26438_L rh:contains1 http://rdf.rhea-db.org/Participant_26438_compound_3378; http://rdf.rhea-db.org/Participant_26438_compound_3378 rh:compound http://rdf.rhea-db.org/Compound_3378; http://rdf.rhea-db.org/Compound_3378 rh:chebi""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-033_861e3b7f1fda	RHEA:26440	pathwaymech:produces	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	RHEA:26440		"[{""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea RHEA:26440 places CHEBI:58349 on its products side with stoichiometric coefficient 1."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:products http://rdf.rhea-db.org/26438_L; http://rdf.rhea-db.org/26438_L rh:contains1 http://rdf.rhea-db.org/Participant_26438_compound_5188; http://rdf.rhea-db.org/Participant_26438_compound_5188 rh:compound http://rdf.rhea-db.org/Compound_5188; http://rdf.rhea-db.org/Compound_5188 rh:chebi""}]"	"[{""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-034_63603286d1bb	UniProtKB:P75893	pathwaymech:enables	RHEA:21622	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:20369853|RHEA:21622|UniProtKB:P75893	Functional protein/activity assertion; no monomeric assembly is inferred.	"[{""reference_id"": ""UniProtKB:P75893"", ""source_assertion"": ""The reviewed entry assigns P75893 to master RHEA:21620 with ECO:0000269 experimental citations; the reaction entry is mapped separately to the selected directed member."", ""source_locator"": ""/comments/1/reaction/reactionCrossReferences; /comments/1/reaction/evidences""}, {""reference_id"": ""RHEA:21622"", ""source_assertion"": ""Rhea master 21620 explicitly links directed member 21622; its substrates and products define the selected pathway orientation."", ""source_locator"": ""http://rdf.rhea-db.org/21620 rh:directionalReaction http://rdf.rhea-db.org/21622; http://rdf.rhea-db.org/21622 rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""PMID:20369853"", ""source_assertion"": ""Partially purified RutF plus purified RutA, NADH and FMN yielded ureidoacrylate; homogeneous Fre substituted in vitro. RutF supplies reduced FMN."", ""source_locator"": ""PMC2873085 paragraphs P1-P2; Figure 1; Scheme 1""}]"	"[{""id"": ""PMID:20369853"", ""source_sha256"": ""90d17c95672e67a431a030970ee81d5cca4e94723f85a8bc3aef998c3ea4d31d"", ""source_version"": ""Complete primary article HTML retrieved 2026-10-11"", ""title"": ""Catalysis of a flavoenzyme-mediated amide hydrolysis"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2873085/""}, {""id"": ""RHEA:21622"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""FMN + NADH + 2 H(+) => FMNH2 + NAD(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P75893"", ""source_sha256"": ""2bd36b7086bfe303be185ba74bf02c2564f4cc63facbc728f3615fe564281fd1"", ""source_version"": ""Reviewed entry version 152, sequence version 3; retrieved 2026-10-11"", ""title"": ""FMN reductase (NADH) RutF"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75893.json""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-035_3864667e4e39	UniProtKB:P75898	pathwaymech:enables	RHEA:31588	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:28661684|RHEA:31588|UniProtKB:P75898	Current net chemistry includes spontaneous NADH reduction of FMN-N5-oxide. The old free-peracid pathway layout is not carried forward; this is not a claim that RutA catalyzes every elementary net substep.	"[{""reference_id"": ""UniProtKB:P75898"", ""source_assertion"": ""The reviewed entry assigns P75898 to master RHEA:31587 with ECO:0000269 experimental citations; the reaction entry is mapped separately to the selected directed member."", ""source_locator"": ""/comments/1/reaction/reactionCrossReferences; /comments/1/reaction/evidences""}, {""reference_id"": ""RHEA:31588"", ""source_assertion"": ""Rhea master 31587 explicitly links directed member 31588; its substrates and products define the selected pathway orientation."", ""source_locator"": ""http://rdf.rhea-db.org/31587 rh:directionalReaction http://rdf.rhea-db.org/31588; http://rdf.rhea-db.org/31588 rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""PMID:28661684"", ""source_assertion"": ""RutA assays without NADH accumulated FMN-N5-oxide, verified against a synthetic standard by chromatography, mass spectrometry and 18O2 labeling."", ""source_locator"": ""PMC6040642 main text following Figure 3; Figure 4A-F""}]"	"[{""id"": ""PMID:28661684"", ""source_sha256"": ""0af939b882d577ee4671ef678a2fac3582aa5edbc73a0616b811e944408c3d7c"", ""source_version"": ""Complete primary article HTML retrieved 2026-10-11"", ""title"": ""RutA-Catalyzed Oxidative Cleavage of the Uracil Amide Involves Formation of a Flavin-N5-oxide"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC6040642/""}, {""id"": ""RHEA:31588"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""uracil + FMNH2 + NADH + O2 => (Z)-3-ureidoacrylate + FMN + NAD(+) + H2O + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P75898"", ""source_sha256"": ""d6dd57671d6b310fb05e9de37dfbbd180f6bf25ba48a0a86c28882549613622d"", ""source_version"": ""Reviewed entry version 160, sequence version 3; retrieved 2026-10-11"", ""title"": ""Pyrimidine monooxygenase RutA"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75898.json""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-036_af3495b54fd7	UniProtKB:P75897	pathwaymech:enables	RHEA:31604	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:20400551|RHEA:31604|UniProtKB:P75897	The explicit intermediate reaction is selected; net RHEA:42624 is excluded to avoid counting carbamate decomposition twice.	"[{""reference_id"": ""UniProtKB:P75897"", ""source_assertion"": ""The reviewed entry assigns P75897 to master RHEA:31603 with ECO:0000269 experimental citations; the reaction entry is mapped separately to the selected directed member."", ""source_locator"": ""/comments/2/reaction/reactionCrossReferences; /comments/2/reaction/evidences""}, {""reference_id"": ""RHEA:31604"", ""source_assertion"": ""Rhea master 31603 explicitly links directed member 31604; its substrates and products define the selected pathway orientation."", ""source_locator"": ""http://rdf.rhea-db.org/31603 rh:directionalReaction http://rdf.rhea-db.org/31604; http://rdf.rhea-db.org/31604 rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""PMID:20400551"", ""source_assertion"": ""RutB hydrolyzed synthetic ureidoacrylate; coupled measurements supported aminoacrylate and carbamate intermediates, followed by spontaneous nitrogen release."", ""source_locator"": ""PMC2916427 Results section sec18 The RutB reaction; Figure 5B; Table 4""}]"	"[{""id"": ""PMID:20400551"", ""source_sha256"": ""c60789961943bfc9ab58db4ef2315c2cb79aca20744dbbafe6371e551157feb8"", ""source_version"": ""Complete primary article HTML retrieved 2026-10-11"", ""title"": ""The Rut Pathway for Pyrimidine Degradation: Novel Chemistry and Toxicity Problems"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2916427/""}, {""id"": ""RHEA:31604"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-ureidoacrylate + H2O => (Z)-3-aminoacrylate + carbamate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P75897"", ""source_sha256"": ""691c608780c38a2e6404384ce0b6d4f1f46746674fa29605926204180c39f9e3"", ""source_version"": ""Reviewed entry version 153, sequence version 2; retrieved 2026-10-11"", ""title"": ""Ureidoacrylate amidohydrolase RutB"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75897.json""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-037_14867feec592	UniProtKB:P0AFQ5	pathwaymech:enables	RHEA:34948	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:23143235|PMID:33839153|RHEA:34948|UniProtKB:P0AFQ5	Functional protein/activity assertion preserves the measured homotrimer without inventing an external complex identifier. The reaction also proceeds spontaneously; RutC is not essential in the tested whole-cell conditions.	"[{""reference_id"": ""UniProtKB:P0AFQ5"", ""source_assertion"": ""The reviewed entry assigns P0AFQ5 to master RHEA:34947 with ECO:0000269 experimental citations; the reaction entry is mapped separately to the selected directed member."", ""source_locator"": ""/comments/1/reaction/reactionCrossReferences; /comments/1/reaction/evidences""}, {""reference_id"": ""RHEA:34948"", ""source_assertion"": ""Rhea master 34947 explicitly links directed member 34948; its substrates and products define the selected pathway orientation."", ""source_locator"": ""http://rdf.rhea-db.org/34947 rh:directionalReaction http://rdf.rhea-db.org/34948; http://rdf.rhea-db.org/34948 rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""PMID:33839153"", ""source_assertion"": ""At 23°C RutC accelerated 3-aminoacrylate deamination in the RutB/YdfG coupled assay; inactive R104A gave the spontaneous background rate."", ""source_locator"": ""PMC8113886 Results: RutC is a 3-AA deaminase; Figure 2; Table 1; Assay for 3-AA deaminase activity""}, {""reference_id"": ""PMID:23143235"", ""source_assertion"": ""Gel filtration demonstrates a RutC trimer in solution; the crystal contains two trimers. The paper's proposed peracid-reductase function is superseded by the 2021 direct deaminase assays."", ""source_locator"": ""PMC3515367 Results and discussion 3.1; Figure 2""}]"	"[{""id"": ""PMID:23143235"", ""source_sha256"": ""925aff4917add679383419b8b1c39a1d4aa0bb6b93ace02fffa8289a01e352bf"", ""source_version"": ""Complete primary article HTML retrieved 2026-10-11"", ""title"": ""Structure of Escherichia coli RutC, a member of the YjgF family and putative aminoacrylate peracid reductase of the rut operon"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC3515367/""}, {""id"": ""PMID:33839153"", ""source_sha256"": ""29c1e99ada2cc0b0b4119f3d734ed2bc155d80acd8ecb730a99c61017118ea34"", ""source_version"": ""Complete primary article XML retrieved 2026-10-11"", ""title"": ""The Rid family member RutC of Escherichia coli is a 3-aminoacrylate deaminase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8113886/fullTextXML""}, {""id"": ""RHEA:34948"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-aminoacrylate + H2O + H(+) => 3-oxopropanoate + NH4(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P0AFQ5"", ""source_sha256"": ""97e829fb19861b20e28ec7b3d1baaff1ea6763393b46c1428bbdcc2300055457"", ""source_version"": ""Reviewed entry version 120, sequence version 1; retrieved 2026-10-11"", ""title"": ""3-aminoacrylate deaminase RutC"", ""url"": ""https://rest.uniprot.org/uniprotkb/P0AFQ5.json""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-038_99edc938a838	UniProtKB:P39831	BFO:0000050	MetaCyc:CPLX0-1962	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-1962|MetaCyc:EG12345-MONOMER|UniProtKB:P39831		"[{""reference_id"": ""MetaCyc:CPLX0-1962"", ""source_assertion"": ""The native YdfG complex contains four EG12345-MONOMER subunits and is annotated to MG1655."", ""source_locator"": ""Protein[@frameid='CPLX0-1962']/component/Protein; component/coefficient; species""}, {""reference_id"": ""MetaCyc:EG12345-MONOMER"", ""source_assertion"": ""Native EG12345-MONOMER carries the UniProt P39831 identity and component-of CPLX0-1962 relationship."", ""source_locator"": ""Protein[@frameid='EG12345-MONOMER']/dblink; component-of""}, {""reference_id"": ""UniProtKB:P39831"", ""source_assertion"": ""The reviewed SUBUNIT annotation describes a homotetramer, a dimer of dimers, with experimental references 12535615 and 21349860."", ""source_locator"": ""/comments/7/texts""}]"	"[{""id"": ""MetaCyc:CPLX0-1962"", ""source_sha256"": ""ed00ac937d62cc9bc28620be2f1de65744d48c795af0a9efdd11a0c8685c78e6"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""3-hydroxy acid dehydrogenase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-1962""}, {""id"": ""MetaCyc:EG12345-MONOMER"", ""source_sha256"": ""5722521e0fa986f6bd4846b2dc2fbb80324e3063c60d34cfc2de3b1af58f20ae"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""YdfG native subunit identity"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:EG12345-MONOMER""}, {""id"": ""UniProtKB:P39831"", ""source_sha256"": ""9c9baf51126ddda9f5d627542c12c7737aed6f4f909e7d9453c71f00e752f528"", ""source_version"": ""Reviewed entry version 171, sequence version 2; retrieved 2026-10-11"", ""title"": ""NADP-dependent 3-hydroxy acid dehydrogenase YdfG"", ""url"": ""https://rest.uniprot.org/uniprotkb/P39831.json""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-039_08dc86004d43	MetaCyc:CPLX0-1962	pathwaymech:catalyzes	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	MetaCyc:CPLX0-1962|PMID:20400551|RHEA:26440|UniProtKB:P39831	Direct biochemical support is for YdfG reduction. Mutant growth defects support detoxification under specified conditions; they do not measure universal wild-type pathway flux.	"[{""reference_id"": ""MetaCyc:CPLX0-1962"", ""source_assertion"": ""The native complex catalyzes ENZRXN0-7359 linked to RXN-8974, the malonic semialdehyde reductase reaction."", ""source_locator"": ""Protein[@frameid='CPLX0-1962']/catalyzes/Enzymatic-Reaction[@frameid='ENZRXN0-7359']/reaction""}, {""reference_id"": ""UniProtKB:P39831"", ""source_assertion"": ""The reviewed YdfG reaction explicitly selects physiological RHEA:26440, right-to-left reduction of 3-oxopropanoate using NADPH, with experimental PMID20400551."", ""source_locator"": ""/comments/5/reaction; /comments/5/physiologicalReactions""}, {""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea master 26438 explicitly links directed member 26440; its substrates and products define the selected pathway orientation."", ""source_locator"": ""http://rdf.rhea-db.org/26438 rh:directionalReaction http://rdf.rhea-db.org/26440; http://rdf.rhea-db.org/26440 rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""PMID:20400551"", ""source_assertion"": ""RutB and YdfG together converted synthetic ureidoacrylate to approximately one equivalent of 3-hydroxypropionate while oxidizing NADPH; product was quantified by GC/MS."", ""source_locator"": ""PMC2916427 Methods sec13; Results sec18; Table 4; Figure 5C""}]"	"[{""id"": ""MetaCyc:CPLX0-1962"", ""source_sha256"": ""ed00ac937d62cc9bc28620be2f1de65744d48c795af0a9efdd11a0c8685c78e6"", ""source_version"": ""MetaCyc 22.5; original native XML retrieved 2026-10-11"", ""title"": ""3-hydroxy acid dehydrogenase"", ""url"": ""https://pathway.yeastgenome.org/getxml?META:CPLX0-1962""}, {""id"": ""PMID:20400551"", ""source_sha256"": ""c60789961943bfc9ab58db4ef2315c2cb79aca20744dbbafe6371e551157feb8"", ""source_version"": ""Complete primary article HTML retrieved 2026-10-11"", ""title"": ""The Rut Pathway for Pyrimidine Degradation: Novel Chemistry and Toxicity Problems"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2916427/""}, {""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P39831"", ""source_sha256"": ""9c9baf51126ddda9f5d627542c12c7737aed6f4f909e7d9453c71f00e752f528"", ""source_version"": ""Reviewed entry version 171, sequence version 2; retrieved 2026-10-11"", ""title"": ""NADP-dependent 3-hydroxy acid dehydrogenase YdfG"", ""url"": ""https://rest.uniprot.org/uniprotkb/P39831.json""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-040_f075e67ac04e	UniProtKB:P75894	pathwaymech:enables	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:20400551|PMID:33839153|RHEA:26440|UniProtKB:P75894	Qualified genetic/annotation inference, not a purified RutE assay or established NADPH specificity. YdfG directly grounds the displayed reduction chemistry.	"[{""reference_id"": ""UniProtKB:P75894"", ""source_assertion"": ""The reviewed entry calls RutE a probable malonic semialdehyde reductase and supplies RHEA:26438 without an experimental reaction evidence code. FUNCTION says it may reduce the toxic intermediate."", ""source_locator"": ""/proteinDescription/recommendedName; /comments/0/texts; /comments/1/reaction""}, {""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea master 26438 explicitly links directed member 26440; its substrates and products define the selected pathway orientation."", ""source_locator"": ""http://rdf.rhea-db.org/26438 rh:directionalReaction http://rdf.rhea-db.org/26440; http://rdf.rhea-db.org/26440 rh:substrates; rh:products; rh:equation""}, {""reference_id"": ""PMID:20400551"", ""source_assertion"": ""Shared suppression of rutE and ydfG defects by nemR lesions leads to the postulate that RutE also reduces malonic semialdehyde. The discussion explicitly calls for biochemical studies of RutE."", ""source_locator"": ""PMC2916427 Results sec24; Discussion sec26""}, {""reference_id"": ""PMID:33839153"", ""source_assertion"": ""Figure 1 distinguishes YdfG reduction demonstrated in vitro from the predicted physiologically relevant RutE enzyme."", ""source_locator"": ""PMC8113886 Figure 1 legend""}]"	"[{""id"": ""PMID:20400551"", ""source_sha256"": ""c60789961943bfc9ab58db4ef2315c2cb79aca20744dbbafe6371e551157feb8"", ""source_version"": ""Complete primary article HTML retrieved 2026-10-11"", ""title"": ""The Rut Pathway for Pyrimidine Degradation: Novel Chemistry and Toxicity Problems"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC2916427/""}, {""id"": ""PMID:33839153"", ""source_sha256"": ""29c1e99ada2cc0b0b4119f3d734ed2bc155d80acd8ecb730a99c61017118ea34"", ""source_version"": ""Complete primary article XML retrieved 2026-10-11"", ""title"": ""The Rid family member RutC of Escherichia coli is a 3-aminoacrylate deaminase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8113886/fullTextXML""}, {""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""UniProtKB:P75894"", ""source_sha256"": ""befb68c7eecba05a370124ec6b079306fd9fd71b1e3ac65e532520e5104170ee"", ""source_version"": ""Reviewed entry version 150, sequence version 1; retrieved 2026-10-11"", ""title"": ""Probable malonic semialdehyde reductase RutE"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75894.json""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-041_6e44f56a9418	UniProtKB:P75894	pathwaymech:has_cofactor	CHEBI:58210	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P75894	Predicted FMN requirement retained with its original evidence tier.	"[{""reference_id"": ""UniProtKB:P75894"", ""source_assertion"": ""RutE FMN cofactor annotation has ECO:0000305 curator inference, not a direct cofactor-binding assay."", ""source_locator"": ""/comments/2/cofactors/0""}]"	"[{""id"": ""UniProtKB:P75894"", ""source_sha256"": ""befb68c7eecba05a370124ec6b079306fd9fd71b1e3ac65e532520e5104170ee"", ""source_version"": ""Reviewed entry version 150, sequence version 1; retrieved 2026-10-11"", ""title"": ""Probable malonic semialdehyde reductase RutE"", ""url"": ""https://rest.uniprot.org/uniprotkb/P75894.json""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-042_2e679756c3ac	RHEA:21622	BFO:0000050	MetaCyc:PWY0-1471	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:28661684|RHEA:21622	Modern biochemical reconstruction of the same uracil-to-3-hydroxypropionate boundary; native22.5 peracid and RutC/RutD assignments are superseded, not asserted equivalent elementary reactions.	"[{""reference_id"": ""PMID:28661684"", ""source_assertion"": ""Figure 1 identifies RutF as the flavin reductase that supplies the reduced cofactor for the first RutA step."", ""source_locator"": ""PMC6040642 Figure 1 legend""}, {""reference_id"": ""RHEA:21622"", ""source_assertion"": ""Rhea master 21620 explicitly links directed member 21622; its substrates and products define the selected pathway orientation."", ""source_locator"": ""http://rdf.rhea-db.org/21620 rh:directionalReaction http://rdf.rhea-db.org/21622; http://rdf.rhea-db.org/21622 rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""PMID:28661684"", ""source_sha256"": ""0af939b882d577ee4671ef678a2fac3582aa5edbc73a0616b811e944408c3d7c"", ""source_version"": ""Complete primary article HTML retrieved 2026-10-11"", ""title"": ""RutA-Catalyzed Oxidative Cleavage of the Uracil Amide Involves Formation of a Flavin-N5-oxide"", ""url"": ""https://pmc.ncbi.nlm.nih.gov/articles/PMC6040642/""}, {""id"": ""RHEA:21622"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""FMN + NADH + 2 H(+) => FMNH2 + NAD(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-043_3dadf7364a72	RHEA:31588	BFO:0000050	MetaCyc:PWY0-1471	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33839153|RHEA:31588	Modern biochemical reconstruction of the same uracil-to-3-hydroxypropionate boundary; native22.5 peracid and RutC/RutD assignments are superseded, not asserted equivalent elementary reactions.	"[{""reference_id"": ""PMID:33839153"", ""source_assertion"": ""The revised Rut model covers ureidoacrylate formation, RutB cleavage, 3-aminoacrylate deamination, carbamate decay and terminal malonate-semialdehyde reduction."", ""source_locator"": ""PMC8113886 Figure 1 and legend; Introduction; Results""}, {""reference_id"": ""RHEA:31588"", ""source_assertion"": ""Rhea master 31587 explicitly links directed member 31588; its substrates and products define the selected pathway orientation."", ""source_locator"": ""http://rdf.rhea-db.org/31587 rh:directionalReaction http://rdf.rhea-db.org/31588; http://rdf.rhea-db.org/31588 rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""PMID:33839153"", ""source_sha256"": ""29c1e99ada2cc0b0b4119f3d734ed2bc155d80acd8ecb730a99c61017118ea34"", ""source_version"": ""Complete primary article XML retrieved 2026-10-11"", ""title"": ""The Rid family member RutC of Escherichia coli is a 3-aminoacrylate deaminase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8113886/fullTextXML""}, {""id"": ""RHEA:31588"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""uracil + FMNH2 + NADH + O2 => (Z)-3-ureidoacrylate + FMN + NAD(+) + H2O + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-044_59e71d56559f	RHEA:31604	BFO:0000050	MetaCyc:PWY0-1471	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33839153|RHEA:31604	Modern biochemical reconstruction of the same uracil-to-3-hydroxypropionate boundary; native22.5 peracid and RutC/RutD assignments are superseded, not asserted equivalent elementary reactions.	"[{""reference_id"": ""PMID:33839153"", ""source_assertion"": ""The revised Rut model covers ureidoacrylate formation, RutB cleavage, 3-aminoacrylate deamination, carbamate decay and terminal malonate-semialdehyde reduction."", ""source_locator"": ""PMC8113886 Figure 1 and legend; Introduction; Results""}, {""reference_id"": ""RHEA:31604"", ""source_assertion"": ""Rhea master 31603 explicitly links directed member 31604; its substrates and products define the selected pathway orientation."", ""source_locator"": ""http://rdf.rhea-db.org/31603 rh:directionalReaction http://rdf.rhea-db.org/31604; http://rdf.rhea-db.org/31604 rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""PMID:33839153"", ""source_sha256"": ""29c1e99ada2cc0b0b4119f3d734ed2bc155d80acd8ecb730a99c61017118ea34"", ""source_version"": ""Complete primary article XML retrieved 2026-10-11"", ""title"": ""The Rid family member RutC of Escherichia coli is a 3-aminoacrylate deaminase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8113886/fullTextXML""}, {""id"": ""RHEA:31604"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-ureidoacrylate + H2O => (Z)-3-aminoacrylate + carbamate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-045_72839e519086	RHEA:15650	BFO:0000050	MetaCyc:PWY0-1471	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33839153|RHEA:15650	Modern biochemical reconstruction of the same uracil-to-3-hydroxypropionate boundary; native22.5 peracid and RutC/RutD assignments are superseded, not asserted equivalent elementary reactions.	"[{""reference_id"": ""PMID:33839153"", ""source_assertion"": ""The revised Rut model covers ureidoacrylate formation, RutB cleavage, 3-aminoacrylate deamination, carbamate decay and terminal malonate-semialdehyde reduction."", ""source_locator"": ""PMC8113886 Figure 1 and legend; Introduction; Results""}, {""reference_id"": ""RHEA:15650"", ""source_assertion"": ""Rhea master 15649 explicitly links directed member 15650; its substrates and products define the selected pathway orientation."", ""source_locator"": ""http://rdf.rhea-db.org/15649 rh:directionalReaction http://rdf.rhea-db.org/15650; http://rdf.rhea-db.org/15650 rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""PMID:33839153"", ""source_sha256"": ""29c1e99ada2cc0b0b4119f3d734ed2bc155d80acd8ecb730a99c61017118ea34"", ""source_version"": ""Complete primary article XML retrieved 2026-10-11"", ""title"": ""The Rid family member RutC of Escherichia coli is a 3-aminoacrylate deaminase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8113886/fullTextXML""}, {""id"": ""RHEA:15650"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""carbamate + 2 H(+) => NH4(+) + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-046_6fe721863b22	RHEA:34948	BFO:0000050	MetaCyc:PWY0-1471	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33839153|RHEA:34948	Modern biochemical reconstruction of the same uracil-to-3-hydroxypropionate boundary; native22.5 peracid and RutC/RutD assignments are superseded, not asserted equivalent elementary reactions.	"[{""reference_id"": ""PMID:33839153"", ""source_assertion"": ""The revised Rut model covers ureidoacrylate formation, RutB cleavage, 3-aminoacrylate deamination, carbamate decay and terminal malonate-semialdehyde reduction."", ""source_locator"": ""PMC8113886 Figure 1 and legend; Introduction; Results""}, {""reference_id"": ""RHEA:34948"", ""source_assertion"": ""Rhea master 34947 explicitly links directed member 34948; its substrates and products define the selected pathway orientation."", ""source_locator"": ""http://rdf.rhea-db.org/34947 rh:directionalReaction http://rdf.rhea-db.org/34948; http://rdf.rhea-db.org/34948 rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""PMID:33839153"", ""source_sha256"": ""29c1e99ada2cc0b0b4119f3d734ed2bc155d80acd8ecb730a99c61017118ea34"", ""source_version"": ""Complete primary article XML retrieved 2026-10-11"", ""title"": ""The Rid family member RutC of Escherichia coli is a 3-aminoacrylate deaminase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8113886/fullTextXML""}, {""id"": ""RHEA:34948"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-aminoacrylate + H2O + H(+) => 3-oxopropanoate + NH4(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-047_f941696a6e95	RHEA:26440	BFO:0000050	MetaCyc:PWY0-1471	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33839153|RHEA:26440	Modern biochemical reconstruction of the same uracil-to-3-hydroxypropionate boundary; native22.5 peracid and RutC/RutD assignments are superseded, not asserted equivalent elementary reactions.	"[{""reference_id"": ""PMID:33839153"", ""source_assertion"": ""The revised Rut model covers ureidoacrylate formation, RutB cleavage, 3-aminoacrylate deamination, carbamate decay and terminal malonate-semialdehyde reduction."", ""source_locator"": ""PMC8113886 Figure 1 and legend; Introduction; Results""}, {""reference_id"": ""RHEA:26440"", ""source_assertion"": ""Rhea master 26438 explicitly links directed member 26440; its substrates and products define the selected pathway orientation."", ""source_locator"": ""http://rdf.rhea-db.org/26438 rh:directionalReaction http://rdf.rhea-db.org/26440; http://rdf.rhea-db.org/26440 rh:substrates; rh:products; rh:equation""}]"	"[{""id"": ""PMID:33839153"", ""source_sha256"": ""29c1e99ada2cc0b0b4119f3d734ed2bc155d80acd8ecb730a99c61017118ea34"", ""source_version"": ""Complete primary article XML retrieved 2026-10-11"", ""title"": ""The Rid family member RutC of Escherichia coli is a 3-aminoacrylate deaminase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8113886/fullTextXML""}, {""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-048_f4e8de2f7a4c	RHEA:21622	RO:0002413	RHEA:31588	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33839153|RHEA:21622|RHEA:31588	Dependency inferred from the inspected pathway and matching current Rhea chemical identities; no physical enzyme channeling is asserted.	"[{""reference_id"": ""PMID:33839153"", ""source_assertion"": ""The revised pathway diagram places FMN-dependent uracil opening before RutB cleavage, branches carbamate decay from aminoacrylate deamination, and ends with semialdehyde reduction."", ""source_locator"": ""PMC8113886 Figure 1 and legend""}, {""reference_id"": ""RHEA:21622"", ""source_assertion"": ""The selected upstream reaction produces CHEBI:57618."", ""source_locator"": ""http://rdf.rhea-db.org/21622 rh:products; corresponding rh:contains/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:31588"", ""source_assertion"": ""The selected downstream reaction consumes the same CHEBI:57618."", ""source_locator"": ""http://rdf.rhea-db.org/31588 rh:substrates; corresponding rh:contains/rh:compound/rh:chebi""}]"	"[{""id"": ""PMID:33839153"", ""source_sha256"": ""29c1e99ada2cc0b0b4119f3d734ed2bc155d80acd8ecb730a99c61017118ea34"", ""source_version"": ""Complete primary article XML retrieved 2026-10-11"", ""title"": ""The Rid family member RutC of Escherichia coli is a 3-aminoacrylate deaminase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8113886/fullTextXML""}, {""id"": ""RHEA:21622"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""FMN + NADH + 2 H(+) => FMNH2 + NAD(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:31588"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""uracil + FMNH2 + NADH + O2 => (Z)-3-ureidoacrylate + FMN + NAD(+) + H2O + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-049_5ebf9ae6f60d	RHEA:31588	RO:0002413	RHEA:21622	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33839153|RHEA:21622|RHEA:31588	Dependency inferred from the inspected pathway and matching current Rhea chemical identities; no physical enzyme channeling is asserted.	"[{""reference_id"": ""PMID:33839153"", ""source_assertion"": ""The revised pathway diagram places FMN-dependent uracil opening before RutB cleavage, branches carbamate decay from aminoacrylate deamination, and ends with semialdehyde reduction."", ""source_locator"": ""PMC8113886 Figure 1 and legend""}, {""reference_id"": ""RHEA:31588"", ""source_assertion"": ""The selected upstream reaction produces CHEBI:58210."", ""source_locator"": ""http://rdf.rhea-db.org/31588 rh:products; corresponding rh:contains/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:21622"", ""source_assertion"": ""The selected downstream reaction consumes the same CHEBI:58210."", ""source_locator"": ""http://rdf.rhea-db.org/21622 rh:substrates; corresponding rh:contains/rh:compound/rh:chebi""}]"	"[{""id"": ""PMID:33839153"", ""source_sha256"": ""29c1e99ada2cc0b0b4119f3d734ed2bc155d80acd8ecb730a99c61017118ea34"", ""source_version"": ""Complete primary article XML retrieved 2026-10-11"", ""title"": ""The Rid family member RutC of Escherichia coli is a 3-aminoacrylate deaminase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8113886/fullTextXML""}, {""id"": ""RHEA:21622"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""FMN + NADH + 2 H(+) => FMNH2 + NAD(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:31588"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""uracil + FMNH2 + NADH + O2 => (Z)-3-ureidoacrylate + FMN + NAD(+) + H2O + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-050_71e7fd1c9aaa	RHEA:31588	RO:0002413	RHEA:31604	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33839153|RHEA:31588|RHEA:31604	Dependency inferred from the inspected pathway and matching current Rhea chemical identities; no physical enzyme channeling is asserted.	"[{""reference_id"": ""PMID:33839153"", ""source_assertion"": ""The revised pathway diagram places FMN-dependent uracil opening before RutB cleavage, branches carbamate decay from aminoacrylate deamination, and ends with semialdehyde reduction."", ""source_locator"": ""PMC8113886 Figure 1 and legend""}, {""reference_id"": ""RHEA:31588"", ""source_assertion"": ""The selected upstream reaction produces CHEBI:59891."", ""source_locator"": ""http://rdf.rhea-db.org/31588 rh:products; corresponding rh:contains/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:31604"", ""source_assertion"": ""The selected downstream reaction consumes the same CHEBI:59891."", ""source_locator"": ""http://rdf.rhea-db.org/31604 rh:substrates; corresponding rh:contains/rh:compound/rh:chebi""}]"	"[{""id"": ""PMID:33839153"", ""source_sha256"": ""29c1e99ada2cc0b0b4119f3d734ed2bc155d80acd8ecb730a99c61017118ea34"", ""source_version"": ""Complete primary article XML retrieved 2026-10-11"", ""title"": ""The Rid family member RutC of Escherichia coli is a 3-aminoacrylate deaminase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8113886/fullTextXML""}, {""id"": ""RHEA:31588"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""uracil + FMNH2 + NADH + O2 => (Z)-3-ureidoacrylate + FMN + NAD(+) + H2O + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:31604"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-ureidoacrylate + H2O => (Z)-3-aminoacrylate + carbamate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-051_9a098c5eb6bd	RHEA:31604	RO:0002413	RHEA:15650	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33839153|RHEA:15650|RHEA:31604	Dependency inferred from the inspected pathway and matching current Rhea chemical identities; no physical enzyme channeling is asserted.	"[{""reference_id"": ""PMID:33839153"", ""source_assertion"": ""The revised pathway diagram places FMN-dependent uracil opening before RutB cleavage, branches carbamate decay from aminoacrylate deamination, and ends with semialdehyde reduction."", ""source_locator"": ""PMC8113886 Figure 1 and legend""}, {""reference_id"": ""RHEA:31604"", ""source_assertion"": ""The selected upstream reaction produces CHEBI:13941."", ""source_locator"": ""http://rdf.rhea-db.org/31604 rh:products; corresponding rh:contains/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:15650"", ""source_assertion"": ""The selected downstream reaction consumes the same CHEBI:13941."", ""source_locator"": ""http://rdf.rhea-db.org/15650 rh:substrates; corresponding rh:contains/rh:compound/rh:chebi""}]"	"[{""id"": ""PMID:33839153"", ""source_sha256"": ""29c1e99ada2cc0b0b4119f3d734ed2bc155d80acd8ecb730a99c61017118ea34"", ""source_version"": ""Complete primary article XML retrieved 2026-10-11"", ""title"": ""The Rid family member RutC of Escherichia coli is a 3-aminoacrylate deaminase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8113886/fullTextXML""}, {""id"": ""RHEA:15650"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""carbamate + 2 H(+) => NH4(+) + CO2"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:31604"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-ureidoacrylate + H2O => (Z)-3-aminoacrylate + carbamate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-052_b80b4f37c6ad	RHEA:31604	RO:0002413	RHEA:34948	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33839153|RHEA:31604|RHEA:34948	Dependency inferred from the inspected pathway and matching current Rhea chemical identities; no physical enzyme channeling is asserted.	"[{""reference_id"": ""PMID:33839153"", ""source_assertion"": ""The revised pathway diagram places FMN-dependent uracil opening before RutB cleavage, branches carbamate decay from aminoacrylate deamination, and ends with semialdehyde reduction."", ""source_locator"": ""PMC8113886 Figure 1 and legend""}, {""reference_id"": ""RHEA:31604"", ""source_assertion"": ""The selected upstream reaction produces CHEBI:59894."", ""source_locator"": ""http://rdf.rhea-db.org/31604 rh:products; corresponding rh:contains/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:34948"", ""source_assertion"": ""The selected downstream reaction consumes the same CHEBI:59894."", ""source_locator"": ""http://rdf.rhea-db.org/34948 rh:substrates; corresponding rh:contains/rh:compound/rh:chebi""}]"	"[{""id"": ""PMID:33839153"", ""source_sha256"": ""29c1e99ada2cc0b0b4119f3d734ed2bc155d80acd8ecb730a99c61017118ea34"", ""source_version"": ""Complete primary article XML retrieved 2026-10-11"", ""title"": ""The Rid family member RutC of Escherichia coli is a 3-aminoacrylate deaminase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8113886/fullTextXML""}, {""id"": ""RHEA:31604"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-ureidoacrylate + H2O => (Z)-3-aminoacrylate + carbamate + H(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:34948"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-aminoacrylate + H2O + H(+) => 3-oxopropanoate + NH4(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:MetaCyc_PWY0-1471_rut-edge-053_9cb7ec74cfc6	RHEA:34948	RO:0002413	RHEA:26440	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	PMID:33839153|RHEA:26440|RHEA:34948	Dependency inferred from the inspected pathway and matching current Rhea chemical identities; no physical enzyme channeling is asserted.	"[{""reference_id"": ""PMID:33839153"", ""source_assertion"": ""The revised pathway diagram places FMN-dependent uracil opening before RutB cleavage, branches carbamate decay from aminoacrylate deamination, and ends with semialdehyde reduction."", ""source_locator"": ""PMC8113886 Figure 1 and legend""}, {""reference_id"": ""RHEA:34948"", ""source_assertion"": ""The selected upstream reaction produces CHEBI:33190."", ""source_locator"": ""http://rdf.rhea-db.org/34948 rh:products; corresponding rh:contains/rh:compound/rh:chebi""}, {""reference_id"": ""RHEA:26440"", ""source_assertion"": ""The selected downstream reaction consumes the same CHEBI:33190."", ""source_locator"": ""http://rdf.rhea-db.org/26440 rh:substrates; corresponding rh:contains/rh:compound/rh:chebi""}]"	"[{""id"": ""PMID:33839153"", ""source_sha256"": ""29c1e99ada2cc0b0b4119f3d734ed2bc155d80acd8ecb730a99c61017118ea34"", ""source_version"": ""Complete primary article XML retrieved 2026-10-11"", ""title"": ""The Rid family member RutC of Escherichia coli is a 3-aminoacrylate deaminase"", ""url"": ""https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8113886/fullTextXML""}, {""id"": ""RHEA:26440"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""3-oxopropanoate + NADPH + H(+) => 3-hydroxypropanoate + NADP(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}, {""id"": ""RHEA:34948"", ""source_sha256"": ""8ee48d7044cf3eef1001fa730dae2a491902ab25b259b519d6826796bb8acedf"", ""source_version"": ""Rhea release 142; digest covers original complete RDF gzip"", ""title"": ""(Z)-3-aminoacrylate + H2O + H(+) => 3-oxopropanoate + NH4(+)"", ""url"": ""https://ftp.expasy.org/databases/rhea/rdf/rhea.rdf.gz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-001_a8513d7479ac	gomodel:ALLOPHANATE-HYDROLASE-RXN	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:ALLOPHANATE-HYDROLASE-RXN RO:0002234 gomodel:YeastPathways_PWY-5703/654d809000001036."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/0; endpoint types: /individuals/0/type; /individuals/45/type""}, {""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:ALLOPHANATE-HYDROLASE-RXN RO:0002234 gomodel:CHEBI_16526_ALLOPHANATE-HYDROLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/10; endpoint types: /individuals/0/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-002_ef107f353a2b	gomodel:UREA-CARBOXYLASE-RXN	RO:0002413	gomodel:ALLOPHANATE-HYDROLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:UREA-CARBOXYLASE-RXN RO:0002413 gomodel:ALLOPHANATE-HYDROLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/1; endpoint types: /individuals/13/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-003_897907e00497	gomodel:ALLOPHANATE-HYDROLASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:ALLOPHANATE-HYDROLASE-RXN RO:0002233 gomodel:CHEBI_15377_ALLOPHANATE-HYDROLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/2; endpoint types: /individuals/0/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-004_316e0edd54a4	gomodel:ALLOPHANATE-HYDROLASE-RXN	RO:0002233	CHEBI:15832	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:ALLOPHANATE-HYDROLASE-RXN RO:0002233 gomodel:CHEBI_15832_UREA-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/3; endpoint types: /individuals/0/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-005_4c079b662ad8	gomodel:ALLOPHANATE-HYDROLASE-RXN	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:ALLOPHANATE-HYDROLASE-RXN RO:0002233 gomodel:CHEBI_15378_ALLOPHANATE-HYDROLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/4; endpoint types: /individuals/0/type; /individuals/3/type""}, {""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:ALLOPHANATE-HYDROLASE-RXN RO:0002233 gomodel:YeastPathways_PWY-5703/654d809000001030."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/20; endpoint types: /individuals/0/type; /individuals/39/type""}, {""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:ALLOPHANATE-HYDROLASE-RXN RO:0002233 gomodel:YeastPathways_PWY-5703/654d809000001032."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/23; endpoint types: /individuals/0/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-006_6616e377de05	gomodel:UREA-CARBOXYLASE-RXN	RO:0002234	CHEBI:16761	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:UREA-CARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_456216_UREA-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/5; endpoint types: /individuals/13/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-007_48a6639fe533	SGD:S000000412	pathwaymech:enables	gomodel:UREA-CARBOXYLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:UREA-CARBOXYLASE-RXN RO:0002333 gomodel:YBR208C-MONOMER_UREA-CARBOXYLASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/6; endpoint types: /individuals/13/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-008_910bf9832436	gomodel:UREA-CARBOXYLASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:UREA-CARBOXYLASE-RXN RO:0002234 gomodel:YeastPathways_PWY-5703/654d809000001028."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/7; endpoint types: /individuals/13/type; /individuals/37/type""}, {""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:UREA-CARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_15378_UREA-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/8; endpoint types: /individuals/13/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-009_ec5f315848e1	SGD:S000000412	pathwaymech:enables	gomodel:ALLOPHANATE-HYDROLASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:ALLOPHANATE-HYDROLASE-RXN RO:0002333 gomodel:YBR208C-MONOMER_ALLOPHANATE-HYDROLASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/9; endpoint types: /individuals/0/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-010_ef342a6378aa	gomodel:UREA-CARBOXYLASE-RXN	RO:0002233	CHEBI:15422	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:UREA-CARBOXYLASE-RXN RO:0002233 gomodel:CHEBI_30616_UREA-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/11; endpoint types: /individuals/13/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-011_45f5fc66ee2a	gomodel:ALLOPHANATE-HYDROLASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:ALLOPHANATE-HYDROLASE-RXN BFO:0000066 gomodel:reaction_ALLOPHANATE-HYDROLASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/12; endpoint types: /individuals/0/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-012_78c16df0ad6e	gomodel:UREA-CARBOXYLASE-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:UREA-CARBOXYLASE-RXN RO:0002233 gomodel:CHEBI_15377_UREA-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/13; endpoint types: /individuals/13/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-013_43680f7010c0	gomodel:UREA-CARBOXYLASE-RXN	BFO:0000050	GO:0043419	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:UREA-CARBOXYLASE-RXN BFO:0000050 gomodel:YeastPathways_PWY-5703/YeastPathways_PWY-5703."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/14; endpoint types: /individuals/13/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-014_2fe92cf1baa7	gomodel:UREA-CARBOXYLASE-RXN	RO:0002233	CHEBI:16199	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:UREA-CARBOXYLASE-RXN RO:0002233 gomodel:CHEBI_16199_UREA-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/15; endpoint types: /individuals/13/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-015_0fc5233a2c13	gomodel:UREA-CARBOXYLASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:UREA-CARBOXYLASE-RXN BFO:0000066 gomodel:reaction_UREA-CARBOXYLASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/16; endpoint types: /individuals/13/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-016_473477b4801a	gomodel:ALLOPHANATE-HYDROLASE-RXN	BFO:0000050	GO:0043419	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:ALLOPHANATE-HYDROLASE-RXN BFO:0000050 gomodel:YeastPathways_PWY-5703/YeastPathways_PWY-5703."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/17; endpoint types: /individuals/0/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-017_e932249447d8	gomodel:UREA-CARBOXYLASE-RXN	RO:0002233	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:UREA-CARBOXYLASE-RXN RO:0002233 gomodel:CHEBI_16526_UREA-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/18; endpoint types: /individuals/13/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-018_725c0d2c0e6b	gomodel:UREA-CARBOXYLASE-RXN	RO:0002234	CHEBI:15832	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:UREA-CARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_15832_UREA-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/19; endpoint types: /individuals/13/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-019_fdf5175b9616	gomodel:UREA-CARBOXYLASE-RXN	RO:0002234	CHEBI:26020	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:UREA-CARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_43474_UREA-CARBOXYLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/21; endpoint types: /individuals/13/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_edge-020_f9ad3a5743aa	gomodel:ALLOPHANATE-HYDROLASE-RXN	RO:0002234	CHEBI:28938	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5703		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:ALLOPHANATE-HYDROLASE-RXN RO:0002234 gomodel:CHEBI_28938_ALLOPHANATE-HYDROLASE-RXN."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/22; endpoint types: /individuals/0/type; /individuals/9/type""}, {""reference_id"": ""gomodel:YeastPathways_PWY-5703"", ""source_assertion"": ""The model asserts gomodel:ALLOPHANATE-HYDROLASE-RXN RO:0002234 gomodel:YeastPathways_PWY-5703/654d809000001034."", ""source_locator"": ""./YeastPathways_PWY-5703.json#/facts/24; endpoint types: /individuals/0/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5703"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_PWY-5703.json"", ""title"": ""GO-CAM urea degradation I model YeastPathways_PWY-5703"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5703_cofactor-ae82980665c2_71b6d3b1b1cc	SGD:S000000412	pathwaymech:has_cofactor	CHEBI:57586	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32528	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P32528"", ""source_assertion"": ""UniProtKB:P32528 annotates CHEBI:57586 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/941/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P32528"", ""source_assertion"": ""UniProtKB:P32528 has the exact SGD cross-reference SGD:S000000412."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/941/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32528"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB P32528 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-001_04b56846abef	gomodel:YeastPathways_PWY-7176/6a4c244800000283	RO:0002233	CHEBI:46398	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7176/6a4c244800000283 RO:0002233 gomodel:CHEBI_46398_UDPKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/0; endpoint types: /individuals/46/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-002_a7fc9126e548	gomodel:CTPSYN-RXN	RO:0002233	CHEBI:58359	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:CTPSYN-RXN RO:0002233 gomodel:CHEBI_58359_CTPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/1; endpoint types: /individuals/15/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-003_1128705c5ee9	gomodel:CTPSYN-RXN	RO:0002234	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:CTPSYN-RXN RO:0002234 gomodel:CHEBI_29985_CTPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/2; endpoint types: /individuals/15/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-004_10342eb6d14f	gomodel:CTPSYN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:CTPSYN-RXN RO:0002233 gomodel:CHEBI_30616_CTPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/3; endpoint types: /individuals/15/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-005_8f40de36bb61	gomodel:YeastPathways_PWY-7176/6a4c244800000283	BFO:0000050	GO:0006207	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7176/6a4c244800000283 BFO:0000050 gomodel:YeastPathways_PWY-7176/YeastPathways_PWY-7176."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/4; endpoint types: /individuals/46/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-006_12e8c6fabd21	gomodel:UDPKIN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:UDPKIN-RXN BFO:0000066 gomodel:reaction_UDPKIN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/5; endpoint types: /individuals/17/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-007_b5ce6c8391f5	gomodel:UDPKIN-RXN	RO:0002233	CHEBI:58223	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:UDPKIN-RXN RO:0002233 gomodel:CHEBI_58223_RXN-12002."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/6; endpoint types: /individuals/17/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-008_f1bab1e72e69	gomodel:YeastPathways_PWY-7176/6a4c244800000283	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7176/6a4c244800000283 RO:0002234 gomodel:YeastPathways_PWY-7176/6a4c244800000288."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/7; endpoint types: /individuals/46/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-009_561eccc23f82	gomodel:YeastPathways_PWY-7176/6a4c244800000283	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7176/6a4c244800000283 BFO:0000066 gomodel:YeastPathways_PWY-7176/6a4c244800000294."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/8; endpoint types: /individuals/46/type; /individuals/56/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-010_dc6c60ea50bc	gomodel:CTPSYN-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:CTPSYN-RXN RO:0002234 gomodel:CHEBI_15378_CTPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/9; endpoint types: /individuals/15/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-011_d77142a984b1	gomodel:RXN-12002	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:RXN-12002 BFO:0000066 gomodel:reaction_RXN-12002_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/10; endpoint types: /individuals/16/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-012_f8e4d2caea82	gomodel:UDPKIN-RXN	BFO:0000050	GO:0006207	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:UDPKIN-RXN BFO:0000050 gomodel:YeastPathways_PWY-7176/YeastPathways_PWY-7176."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/11; endpoint types: /individuals/17/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-013_8a6852606f59	gomodel:YeastPathways_PWY-7176/6a4c244800000283	RO:0002233	CHEBI:58359	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7176/6a4c244800000283 RO:0002233 gomodel:YeastPathways_PWY-7176/6a4c244800000284."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/12; endpoint types: /individuals/46/type; /individuals/47/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-014_f85874e3e677	gomodel:RXN-12002	BFO:0000050	GO:0006207	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:RXN-12002 BFO:0000050 gomodel:YeastPathways_PWY-7176/YeastPathways_PWY-7176."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/13; endpoint types: /individuals/16/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-015_79aeebfa80f7	gomodel:CTPSYN-RXN	BFO:0000050	GO:0006207	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:CTPSYN-RXN BFO:0000050 gomodel:YeastPathways_PWY-7176/YeastPathways_PWY-7176."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/14; endpoint types: /individuals/15/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-016_31ce757b1abf	gomodel:UDPKIN-RXN	RO:0002234	CHEBI:46398	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:UDPKIN-RXN RO:0002234 gomodel:CHEBI_46398_UDPKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/15; endpoint types: /individuals/17/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-017_6175369ab61b	gomodel:YeastPathways_PWY-7176/6a4c244800000283	RO:0002234	CHEBI:37563	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7176/6a4c244800000283 RO:0002234 gomodel:YeastPathways_PWY-7176/6a4c244800000291."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/16; endpoint types: /individuals/46/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-018_4328b5f05e7a	gomodel:UDPKIN-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:UDPKIN-RXN RO:0002234 gomodel:CHEBI_456216_UDPKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/17; endpoint types: /individuals/17/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-019_43c30fae5922	gomodel:UDPKIN-RXN	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:UDPKIN-RXN RO:0002233 gomodel:CHEBI_30616_UDPKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/18; endpoint types: /individuals/17/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-020_f501829a28ef	SGD:S000001550	pathwaymech:enables	gomodel:UDPKIN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:UDPKIN-RXN RO:0002333 gomodel:YeastPathways_PWY-7176/6690711d00000620."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/19; endpoint types: /individuals/17/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-021_e288a9e91c35	SGD:S000003864	pathwaymech:enables	gomodel:CTPSYN-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:CTPSYN-RXN RO:0002333 gomodel:YJR103W-MONOMER_CTPSYN-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/20; endpoint types: /individuals/15/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-022_8374e94ae7cd	gomodel:RXN-12002	RO:0002234	CHEBI:58223	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:RXN-12002 RO:0002234 gomodel:CHEBI_58223_RXN-12002."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/21; endpoint types: /individuals/16/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-023_68b3badb7315	gomodel:YeastPathways_PWY-7176/6a4c244800000283	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7176/6a4c244800000283 RO:0002234 gomodel:YeastPathways_PWY-7176/6a4c244800000290."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/22; endpoint types: /individuals/46/type; /individuals/53/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-024_0b0fd811f149	gomodel:CTPSYN-RXN	RO:0002233	CHEBI:46398	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:CTPSYN-RXN RO:0002233 gomodel:CHEBI_46398_UDPKIN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/23; endpoint types: /individuals/15/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-025_40b0214f6fb2	gomodel:RXN-12002	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:RXN-12002 RO:0002234 gomodel:CHEBI_456216_RXN-12002."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/24; endpoint types: /individuals/16/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-026_40d8057005f7	gomodel:YeastPathways_PWY-7176/6a4c244800000283	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7176/6a4c244800000283 RO:0002233 gomodel:YeastPathways_PWY-7176/6a4c244800000285."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/25; endpoint types: /individuals/46/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-027_f812d9c3b153	gomodel:CTPSYN-RXN	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:CTPSYN-RXN RO:0002234 gomodel:CHEBI_43474_CTPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/26; endpoint types: /individuals/15/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-028_9552953c2453	gomodel:YeastPathways_PWY-7176/6a4c244800000283	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7176/6a4c244800000283 RO:0002233 gomodel:YeastPathways_PWY-7176/6a4c244800000286."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/27; endpoint types: /individuals/46/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-029_d3a12c81084d	gomodel:YeastPathways_PWY-7176/6a4c244800000283	RO:0002234	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7176/6a4c244800000283 RO:0002234 gomodel:YeastPathways_PWY-7176/6a4c244800000287."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/28; endpoint types: /individuals/46/type; /individuals/50/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-030_1097f2842c7c	gomodel:RXN-12002	RO:0002233	CHEBI:30616	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:RXN-12002 RO:0002233 gomodel:CHEBI_30616_RXN-12002."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/29; endpoint types: /individuals/16/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-031_22c2be03de7e	gomodel:RXN-12002	RO:0002233	CHEBI:57865	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:RXN-12002 RO:0002233 gomodel:CHEBI_57865_RXN-12002."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/30; endpoint types: /individuals/16/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-032_a74042a0bf04	SGD:S000000135	pathwaymech:enables	gomodel:YeastPathways_PWY-7176/6a4c244800000283	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7176/6a4c244800000283 RO:0002333 gomodel:YeastPathways_PWY-7176/6a4c244800000292."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/31; endpoint types: /individuals/46/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-033_007d900d363a	gomodel:CTPSYN-RXN	RO:0002234	CHEBI:456216	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:CTPSYN-RXN RO:0002234 gomodel:CHEBI_456216_CTPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/32; endpoint types: /individuals/15/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-034_aaeb63678e48	SGD:S000001507	pathwaymech:enables	gomodel:RXN-12002	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:RXN-12002 RO:0002333 gomodel:YKL024C-MONOMER_RXN-12002_controller."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/33; endpoint types: /individuals/16/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-035_c5e539b959f7	gomodel:CTPSYN-RXN	RO:0002233	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:CTPSYN-RXN RO:0002233 gomodel:CHEBI_15377_CTPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/34; endpoint types: /individuals/15/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-036_ece1d58fc380	gomodel:CTPSYN-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:CTPSYN-RXN BFO:0000066 gomodel:reaction_CTPSYN-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/35; endpoint types: /individuals/15/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-037_2b1fbf6d3372	gomodel:CTPSYN-RXN	RO:0002234	CHEBI:37563	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:CTPSYN-RXN RO:0002234 gomodel:CHEBI_37563_CTPSYN-RXN."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/36; endpoint types: /individuals/15/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_edge-038_5db5777d12a7	gomodel:YeastPathways_PWY-7176/6a4c244800000283	RO:0002234	CHEBI:43474	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-7176		"[{""reference_id"": ""gomodel:YeastPathways_PWY-7176"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-7176/6a4c244800000283 RO:0002234 gomodel:YeastPathways_PWY-7176/6a4c244800000289."", ""source_locator"": ""./YeastPathways_PWY-7176.json#/facts/37; endpoint types: /individuals/46/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-7176"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY-7176.json"", ""title"": ""GO-CAM UTP and CTP de novo biosynthesis model YeastPathways_PWY-7176"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_location-77bf27fc8523_d6a6c41770e4	SGD:S000001550	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36010	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12472466) Source qualification: Localizes predominantly to the cytoplasm. A small fraction is present in the mitochondrial intermembrane space	"[{""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 has the exact SGD cross-reference SGD:S000001550."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P36010"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36010 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_location-551208086c3a_e4ab7098db6e	SGD:S000001550	RO:0001025	GO:0005758	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36010	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12472466); ECO:0000269 (PubMed:16823961); ECO:0000269 (PubMed:22984289) Source qualification: Localizes predominantly to the cytoplasm. A small fraction is present in the mitochondrial intermembrane space	"[{""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 annotates location Mitochondrion intermembrane space (SL-0169)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 has the exact SGD cross-reference SGD:S000001550."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P36010"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36010 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_location-c2948defff32_a0ed4e44a5b1	SGD:S000003864	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38627	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38627"", ""source_assertion"": ""UniProtKB:P38627 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1397/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38627"", ""source_assertion"": ""UniProtKB:P38627 has the exact SGD cross-reference SGD:S000003864."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1397/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38627"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38627 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_location-a2a6f57b59f0_4960fca5200e	SGD:S000001507	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15700	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03172); ECO:0000269 (PubMed:1333436); ECO:0000269 (PubMed:8391780) Source qualification: Predominantly cytoplasmic	"[{""reference_id"": ""UniProtKB:P15700"", ""source_assertion"": ""UniProtKB:P15700 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/422/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P15700"", ""source_assertion"": ""UniProtKB:P15700 has the exact SGD cross-reference SGD:S000001507."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/422/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P15700"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P15700 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_location-1b5902281c56_86585fc61f64	SGD:S000001507	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15700	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03172); ECO:0000269 (PubMed:1333436); ECO:0000269 (PubMed:8391780) Source qualification: Predominantly cytoplasmic	"[{""reference_id"": ""UniProtKB:P15700"", ""source_assertion"": ""UniProtKB:P15700 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/422/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P15700"", ""source_assertion"": ""UniProtKB:P15700 has the exact SGD cross-reference SGD:S000001507."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/422/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P15700"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P15700 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_cofactor-857dafe2b77d_a5b311522c9f	SGD:S000001550	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P36010	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:5793714)	"[{""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1183/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P36010"", ""source_assertion"": ""UniProtKB:P36010 has the exact SGD cross-reference SGD:S000001550."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1183/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P36010"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P36010 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_cofactor-30b0b121a794_1a1da413296a	SGD:S000003864	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38627	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P38627"", ""source_assertion"": ""UniProtKB:P38627 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1397/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P38627"", ""source_assertion"": ""UniProtKB:P38627 has the exact SGD cross-reference SGD:S000003864."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1397/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38627"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38627 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-7176_cofactor-4142683ba983_306fb1068432	SGD:S000001507	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P15700	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The dispute concerns nucleoside substrate specificity, not magnesium dependence; keep the metal assertion without expanding substrate scope. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03172); ECO:0000269 (PubMed:16240436); ECO:0000269 (PubMed:8391780) Binds 1 Mg(2+) ion per monomer. UniProt note evidence: ECO:0000255 (HAMAP-Rule:MF_03172); ECO:0000269 (PubMed:16240436); ECO:0000269 (PubMed:8391780)	"[{""reference_id"": ""UniProtKB:P15700"", ""source_assertion"": ""UniProtKB:P15700 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/422/comments/0/cofactors/0; /results/422/comments/0/note""}, {""reference_id"": ""UniProtKB:P15700"", ""source_assertion"": ""UniProtKB:P15700 has the exact SGD cross-reference SGD:S000001507."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/422/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P15700"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P15700 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-001_c60c639bc0b9	gomodel:YeastPathways_PWY3O-4105/6a4c244800003112	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003202	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003202."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/0; endpoint types: /individuals/50/type; /individuals/124/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-002_3a3eb0ede0bb	gomodel:YeastPathways_PWY3O-4105/6a4c244800003112	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003113."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/1; endpoint types: /individuals/50/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-003_ac402cced710	gomodel:RXN3O-4133	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003142	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4133 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003142."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/2; endpoint types: /individuals/10/type; /individuals/76/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-004_51c53ed3fb94	gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003112	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003112."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/3; endpoint types: /individuals/0/type; /individuals/50/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-005_9e22814271f5	gomodel:YeastPathways_PWY3O-4105/6a4c244800003097	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003112	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003112."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/4; endpoint types: /individuals/36/type; /individuals/50/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-006_fb804c8bb58c	gomodel:YeastPathways_PWY3O-4105/6a4c244800003163	BFO:0000050	GO:0006574	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003163 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/5; endpoint types: /individuals/92/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-007_efa83d85d3bd	gomodel:YeastPathways_PWY3O-4105/6a4c244800003163	RO:0002233	CHEBI:48943	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003163 RO:0002233 gomodel:CHEBI_48943_RXN3O-4133."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/6; endpoint types: /individuals/92/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-008_cd41c0ed81cd	gomodel:YeastPathways_PWY3O-4105/6a4c244800003202	BFO:0000050	GO:0006574	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003202 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/7; endpoint types: /individuals/124/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-009_ff56fa02eeb9	gomodel:YeastPathways_PWY3O-4105/6a4c244800003124	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003125."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/8; endpoint types: /individuals/60/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-010_6da0e554eda6	gomodel:YeastPathways_PWY3O-4105/6a4c244800003202	RO:0002233	CHEBI:48943	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003202 RO:0002233 gomodel:CHEBI_48943_RXN3O-4133."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/9; endpoint types: /individuals/124/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-011_d2fe65aa9beb	gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003124	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003124."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/10; endpoint types: /individuals/0/type; /individuals/60/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-012_23eaa0cb0866	gomodel:YeastPathways_PWY3O-4105/6a4c244800003112	RO:0002233	CHEBI:11851	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002233 gomodel:CHEBI_11851_BRANCHED-CHAINAMINOTRANSFERVAL-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/11; endpoint types: /individuals/50/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-013_d5823b996109	gomodel:YeastPathways_PWY3O-4105/6a4c244800003112	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003163	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003163."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/12; endpoint types: /individuals/50/type; /individuals/92/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-014_7e739d96ceba	gomodel:YeastPathways_PWY3O-4105/6a4c244800003124	RO:0002234	CHEBI:48943	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002234 gomodel:CHEBI_48943_RXN3O-4133."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/13; endpoint types: /individuals/60/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-015_baf0c955a947	gomodel:YeastPathways_PWY3O-4105/6a4c244800003142	BFO:0000050	GO:0006574	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003142 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/14; endpoint types: /individuals/76/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-016_8e2773513923	gomodel:YeastPathways_PWY3O-4105/6a4c244800003142	RO:0002233	CHEBI:48943	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003142 RO:0002233 gomodel:CHEBI_48943_RXN3O-4133."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/15; endpoint types: /individuals/76/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-017_b8d17f36662d	gomodel:YeastPathways_PWY3O-4105/6a4c244800003097	BFO:0000050	GO:0006574	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/16; endpoint types: /individuals/36/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-018_f4275d065887	gomodel:YeastPathways_PWY3O-4105/6a4c244800003220	RO:0002233	CHEBI:48943	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003220 RO:0002233 gomodel:CHEBI_48943_RXN3O-4133."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/17; endpoint types: /individuals/140/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-019_74a57ad80492	SGD:S000004918	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4105/6a4c244800003142	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003142 RO:0002333 gomodel:YeastPathways_PWY3O-4105/6a4c244800003146."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/18; endpoint types: /individuals/76/type; /individuals/80/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-020_1593984413e1	gomodel:YeastPathways_PWY3O-4105/6a4c244800003112	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 BFO:0000066 gomodel:YeastPathways_PWY3O-4105/6a4c244800003117."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/19; endpoint types: /individuals/50/type; /individuals/53/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-021_87d326ed0f78	gomodel:YeastPathways_PWY3O-4105/6a4c244800003097	RO:0002234	CHEBI:11851	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 RO:0002234 gomodel:CHEBI_11851_BRANCHED-CHAINAMINOTRANSFERVAL-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/20; endpoint types: /individuals/36/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-022_37691b511b25	gomodel:RXN3O-4133	RO:0002234	CHEBI:48943	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4133 RO:0002234 gomodel:CHEBI_48943_RXN3O-4133."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/21; endpoint types: /individuals/10/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-023_046ee6e1f84d	gomodel:YeastPathways_PWY3O-4105/6a4c244800003202	RO:0002234	CHEBI:46645	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003202 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003205."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/22; endpoint types: /individuals/124/type; /individuals/127/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-024_b5552b042c3a	gomodel:YeastPathways_PWY3O-4105/6a4c244800003124	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003183	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003183."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/23; endpoint types: /individuals/60/type; /individuals/108/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-025_3b833d7b1aa6	gomodel:YeastPathways_PWY3O-4105/6a4c244800003124	BFO:0000050	GO:0006574	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/24; endpoint types: /individuals/60/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-026_d4a34b2be8c6	gomodel:RXN3O-4133	RO:0002413	gomodel:RXN3O-4141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4133 RO:0002413 gomodel:RXN3O-4141."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/25; endpoint types: /individuals/10/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-027_c70d502488bb	SGD:S000004034	pathwaymech:enables	gomodel:RXN3O-4133	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4133 RO:0002333 gomodel:YeastPathways_PWY3O-4105/6690711d00000712."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/26; endpoint types: /individuals/10/type; /individuals/156/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-028_6dac5b5a9f94	gomodel:YeastPathways_PWY3O-4105/6a4c244800003124	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003142	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003142."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/27; endpoint types: /individuals/60/type; /individuals/76/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-029_cf6f1e109351	SGD:S000001251	pathwaymech:enables	gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN RO:0002333 gomodel:YHR208W-MONOMER_BRANCHED-CHAINAMINOTRANSFERVAL-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/28; endpoint types: /individuals/0/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-030_bb1d977f3ec7	gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN	BFO:0000050	GO:0006574	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/29; endpoint types: /individuals/0/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-031_58da04977884	gomodel:YeastPathways_PWY3O-4105/6a4c244800003124	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003163	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003163."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/30; endpoint types: /individuals/60/type; /individuals/92/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-032_8c4b792bcf21	gomodel:YeastPathways_PWY3O-4105/6a4c244800003202	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003202 BFO:0000066 gomodel:YeastPathways_PWY3O-4105/6a4c244800003209."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/31; endpoint types: /individuals/124/type; /individuals/129/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-033_aae517905005	gomodel:YeastPathways_PWY3O-4105/6a4c244800003112	RO:0002413	gomodel:RXN3O-4141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002413 gomodel:RXN3O-4141."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/32; endpoint types: /individuals/50/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-035_a8ef203dc613	gomodel:YeastPathways_PWY3O-4105/6a4c244800003183	RO:0002234	CHEBI:46645	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003183 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003186."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/34; endpoint types: /individuals/108/type; /individuals/111/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-036_42eb5f2344b6	gomodel:YeastPathways_PWY3O-4105/6a4c244800003124	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003220	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003220."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/35; endpoint types: /individuals/60/type; /individuals/140/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-037_48689704b372	gomodel:YeastPathways_PWY3O-4105/6a4c244800003220	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003220 RO:0002233 gomodel:YeastPathways_PWY3O-4105/6a4c244800003221."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/36; endpoint types: /individuals/140/type; /individuals/141/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-038_340c03bb2023	gomodel:YeastPathways_PWY3O-4105/6a4c244800003097	RO:0002234	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003100."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/37; endpoint types: /individuals/36/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-039_cefeb765a6de	gomodel:RXN3O-4133	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003183	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4133 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003183."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/38; endpoint types: /individuals/10/type; /individuals/108/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-040_e222b1435117	gomodel:YeastPathways_PWY3O-4105/6a4c244800003142	RO:0002234	CHEBI:46645	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003142 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003145."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/39; endpoint types: /individuals/76/type; /individuals/79/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-041_c5a136180d79	gomodel:RXN3O-4133	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4133 BFO:0000066 gomodel:reaction_RXN3O-4133_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/40; endpoint types: /individuals/10/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-042_b78756adffd9	SGD:S000000349	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4105/6a4c244800003202	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003202 RO:0002333 gomodel:YeastPathways_PWY3O-4105/6a4c244800003207."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/41; endpoint types: /individuals/124/type; /individuals/128/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-043_c67f24e9367e	gomodel:YeastPathways_PWY3O-4105/6a4c244800003163	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003163 RO:0002233 gomodel:YeastPathways_PWY3O-4105/6a4c244800003164."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/42; endpoint types: /individuals/92/type; /individuals/93/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-044_93689ac87d10	gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN	RO:0002233	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN RO:0002233 gomodel:CHEBI_16810_BRANCHED-CHAINAMINOTRANSFERVAL-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/43; endpoint types: /individuals/0/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-045_2f0671c57a7e	gomodel:YeastPathways_PWY3O-4105/6a4c244800003183	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003183 RO:0002233 gomodel:YeastPathways_PWY3O-4105/6a4c244800003184."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/44; endpoint types: /individuals/108/type; /individuals/109/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-046_e8ddbe0aafab	gomodel:YeastPathways_PWY3O-4105/6a4c244800003097	RO:0002233	CHEBI:16810	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 RO:0002233 gomodel:YeastPathways_PWY3O-4105/6a4c244800003099."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/45; endpoint types: /individuals/36/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-047_8ab8bdeed944	gomodel:RXN3O-4133	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4133 RO:0002234 gomodel:CHEBI_16526_RXN3O-4133."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/46; endpoint types: /individuals/10/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-048_6dbeac5b01df	gomodel:YeastPathways_PWY3O-4105/6a4c244800003097	RO:0002413	gomodel:RXN3O-4133	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 RO:0002413 gomodel:RXN3O-4133."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/47; endpoint types: /individuals/36/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-049_5138409a4dbf	gomodel:RXN3O-4141	RO:0002234	CHEBI:46645	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4141 RO:0002234 gomodel:CHEBI_46645_RXN3O-4141."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/48; endpoint types: /individuals/11/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-051_3145b9119e20	gomodel:YeastPathways_PWY3O-4105/6a4c244800003124	RO:0002413	gomodel:RXN3O-4141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002413 gomodel:RXN3O-4141."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/50; endpoint types: /individuals/60/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-052_679e2c5fb5e7	gomodel:YeastPathways_PWY3O-4105/6a4c244800003183	RO:0002233	CHEBI:48943	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003183 RO:0002233 gomodel:CHEBI_48943_RXN3O-4133."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/51; endpoint types: /individuals/108/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-053_c5f0542e8912	gomodel:YeastPathways_PWY3O-4105/6a4c244800003183	BFO:0000050	GO:0006574	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003183 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/52; endpoint types: /individuals/108/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-054_15f9ab7da7cc	gomodel:YeastPathways_PWY3O-4105/6a4c244800003112	RO:0002234	CHEBI:48943	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002234 gomodel:CHEBI_48943_RXN3O-4133."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/53; endpoint types: /individuals/50/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-055_24f4d7b37800	SGD:S000003319	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4105/6a4c244800003112	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002333 gomodel:YeastPathways_PWY3O-4105/6a4c244800003115."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/54; endpoint types: /individuals/50/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-056_db692c85d33b	gomodel:RXN3O-4133	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003220	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4133 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003220."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/55; endpoint types: /individuals/10/type; /individuals/140/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-057_a57aff303b8a	gomodel:RXN3O-4133	RO:0002233	CHEBI:11851	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4133 RO:0002233 gomodel:CHEBI_11851_BRANCHED-CHAINAMINOTRANSFERVAL-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/56; endpoint types: /individuals/10/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-058_4a575475c4bd	gomodel:RXN3O-4141	RO:0002233	CHEBI:48943	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4141 RO:0002233 gomodel:CHEBI_48943_RXN3O-4133."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/57; endpoint types: /individuals/11/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-059_b1dc0d909074	gomodel:YeastPathways_PWY3O-4105/6a4c244800003220	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003220 BFO:0000066 gomodel:YeastPathways_PWY3O-4105/6a4c244800003226."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/58; endpoint types: /individuals/140/type; /individuals/145/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-060_37034dcc9959	gomodel:YeastPathways_PWY3O-4105/6a4c244800003163	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003163 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003165."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/59; endpoint types: /individuals/92/type; /individuals/94/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-061_2e1324c93d45	SGD:S000005446	pathwaymech:enables	gomodel:RXN3O-4141	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4141 RO:0002333 gomodel:YOL086C-MONOMER_RXN3O-4141_controller."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/60; endpoint types: /individuals/11/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-062_8a483ccf396d	gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN	RO:0002234	CHEBI:11851	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN RO:0002234 gomodel:CHEBI_11851_BRANCHED-CHAINAMINOTRANSFERVAL-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/61; endpoint types: /individuals/0/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-063_82f4ecf1ecd5	gomodel:RXN3O-4141	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4141 BFO:0000066 gomodel:reaction_RXN3O-4141_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/62; endpoint types: /individuals/11/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-064_1afc12922b4a	gomodel:RXN3O-4141	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4141 RO:0002234 gomodel:CHEBI_57540_RXN3O-4141."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/63; endpoint types: /individuals/11/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-065_08ac82679cf1	gomodel:YeastPathways_PWY3O-4105/6a4c244800003202	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003202 RO:0002233 gomodel:YeastPathways_PWY3O-4105/6a4c244800003203."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/64; endpoint types: /individuals/124/type; /individuals/125/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-066_777e506f8b2c	gomodel:YeastPathways_PWY3O-4105/6a4c244800003183	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003183 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003185."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/65; endpoint types: /individuals/108/type; /individuals/110/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-067_7d0d266685f7	SGD:S000003225	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4105/6a4c244800003183	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003183 RO:0002333 gomodel:YeastPathways_PWY3O-4105/6a4c244800003188."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/66; endpoint types: /individuals/108/type; /individuals/112/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-068_4aa0a3fe4826	gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN	RO:0002234	CHEBI:29985	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN RO:0002234 gomodel:CHEBI_29985_BRANCHED-CHAINAMINOTRANSFERVAL-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/67; endpoint types: /individuals/0/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-069_3fee9e00edc0	gomodel:RXN3O-4133	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003202	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4133 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003202."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/68; endpoint types: /individuals/10/type; /individuals/124/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-070_c3cd9ff19d04	gomodel:YeastPathways_PWY3O-4105/6a4c244800003142	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003142 RO:0002233 gomodel:YeastPathways_PWY3O-4105/6a4c244800003143."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/69; endpoint types: /individuals/76/type; /individuals/77/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-071_25aebafad42c	gomodel:YeastPathways_PWY3O-4105/6a4c244800003220	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003220 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003222."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/70; endpoint types: /individuals/140/type; /individuals/142/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-072_4b076ea9f8ff	gomodel:YeastPathways_PWY3O-4105/6a4c244800003097	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 BFO:0000066 gomodel:YeastPathways_PWY3O-4105/6a4c244800003103."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/71; endpoint types: /individuals/36/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-073_2d5e138a0d54	gomodel:RXN3O-4133	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003163	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4133 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003163."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/72; endpoint types: /individuals/10/type; /individuals/92/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-074_0ae3a65cfc70	gomodel:YeastPathways_PWY3O-4105/6a4c244800003112	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003220	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003220."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/73; endpoint types: /individuals/50/type; /individuals/140/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-075_7459efa2f177	gomodel:YeastPathways_PWY3O-4105/6a4c244800003112	BFO:0000050	GO:0006574	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/74; endpoint types: /individuals/50/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-076_ecc4972b78f7	gomodel:YeastPathways_PWY3O-4105/6a4c244800003124	RO:0002233	CHEBI:11851	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002233 gomodel:CHEBI_11851_BRANCHED-CHAINAMINOTRANSFERVAL-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/75; endpoint types: /individuals/60/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-077_cc53415d3c70	gomodel:YeastPathways_PWY3O-4105/6a4c244800003142	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003142 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003144."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/76; endpoint types: /individuals/76/type; /individuals/78/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-078_a09977bda70e	gomodel:YeastPathways_PWY3O-4105/6a4c244800003142	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003142 BFO:0000066 gomodel:YeastPathways_PWY3O-4105/6a4c244800003152."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/77; endpoint types: /individuals/76/type; /individuals/81/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-079_88599e7dbeba	gomodel:YeastPathways_PWY3O-4105/6a4c244800003097	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003124	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003124."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/78; endpoint types: /individuals/36/type; /individuals/60/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-080_97288bb645e6	gomodel:YeastPathways_PWY3O-4105/6a4c244800003220	BFO:0000050	GO:0006574	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003220 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/79; endpoint types: /individuals/140/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-081_64b4964f9563	gomodel:YeastPathways_PWY3O-4105/6a4c244800003202	RO:0002234	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003202 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003204."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/80; endpoint types: /individuals/124/type; /individuals/126/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-083_7f725d4863e7	gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN	RO:0002233	CHEBI:57762	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN RO:0002233 gomodel:CHEBI_57762_BRANCHED-CHAINAMINOTRANSFERVAL-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/82; endpoint types: /individuals/0/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-084_5d9d59940581	gomodel:RXN3O-4133	BFO:0000050	GO:0006574	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4133 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/83; endpoint types: /individuals/10/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-085_505deee76871	gomodel:RXN3O-4141	RO:0002233	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4141 RO:0002233 gomodel:CHEBI_57945_RXN3O-4141."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/84; endpoint types: /individuals/11/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-086_20844e6bf6dd	gomodel:YeastPathways_PWY3O-4105/6a4c244800003124	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 BFO:0000066 gomodel:YeastPathways_PWY3O-4105/6a4c244800003129."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/85; endpoint types: /individuals/60/type; /individuals/63/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-087_06ff403f85ca	SGD:S000002327	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4105/6a4c244800003220	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003220 RO:0002333 gomodel:YeastPathways_PWY3O-4105/6a4c244800003225."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/86; endpoint types: /individuals/140/type; /individuals/144/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-088_1d15e9e66422	gomodel:YeastPathways_PWY3O-4105/6a4c244800003163	RO:0002234	CHEBI:46645	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003163 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003166."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/87; endpoint types: /individuals/92/type; /individuals/95/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-089_63273a8dd112	gomodel:YeastPathways_PWY3O-4105/6a4c244800003112	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003142	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003142."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/88; endpoint types: /individuals/50/type; /individuals/76/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-090_06d632ba5472	SGD:S000004688	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4105/6a4c244800003163	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003163 RO:0002333 gomodel:YeastPathways_PWY3O-4105/6a4c244800003167."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/89; endpoint types: /individuals/92/type; /individuals/96/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-091_27f8fc429ebf	gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN	RO:0002413	gomodel:RXN3O-4133	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN RO:0002413 gomodel:RXN3O-4133."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/90; endpoint types: /individuals/0/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-092_b36405cc6902	SGD:S000003909	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4105/6a4c244800003097	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 RO:0002333 gomodel:YeastPathways_PWY3O-4105/6a4c244800003101."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/91; endpoint types: /individuals/36/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-093_ab3f63829706	SGD:S000004124	pathwaymech:enables	gomodel:YeastPathways_PWY3O-4105/6a4c244800003124	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002333 gomodel:YeastPathways_PWY3O-4105/6a4c244800003128."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/92; endpoint types: /individuals/60/type; /individuals/62/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-094_186cf63c005b	gomodel:YeastPathways_PWY3O-4105/6a4c244800003220	RO:0002234	CHEBI:46645	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003220 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003223."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/93; endpoint types: /individuals/140/type; /individuals/143/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-095_7bf946aeb943	gomodel:RXN3O-4141	BFO:0000050	GO:0006574	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:RXN3O-4141 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/94; endpoint types: /individuals/11/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-096_8d6042cd3eef	gomodel:YeastPathways_PWY3O-4105/6a4c244800003112	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003183	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003183."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/95; endpoint types: /individuals/50/type; /individuals/108/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-097_860bd1dad409	gomodel:YeastPathways_PWY3O-4105/6a4c244800003124	RO:0002413	gomodel:YeastPathways_PWY3O-4105/6a4c244800003202	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003202."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/96; endpoint types: /individuals/60/type; /individuals/124/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_edge-098_369c6290ff66	gomodel:YeastPathways_PWY3O-4105/6a4c244800003097	RO:0002233	CHEBI:57762	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-4105		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 RO:0002233 gomodel:YeastPathways_PWY3O-4105/6a4c244800003098."", ""source_locator"": ""./YeastPathways_PWY3O-4105.json#/facts/97; endpoint types: /individuals/36/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-4105"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json"", ""title"": ""SGD GO-CAM valine degradation pathway PWY3O-4105"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_location-83d9f7cee755_2fea97f04460	SGD:S000004918	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00331	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:2937632)	"[{""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00331"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00331 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_location-e48c97df72e4_4c8d77864b5e	SGD:S000004034	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06169	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P06169"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06169 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_location-d8ee7aa94925_38897f884d28	SGD:S000004034	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06169	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P06169"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06169 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_location-f9bd1202481b_42e8e59a1d3e	SGD:S000001251	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38891	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:21267457); ECO:0000269 (PubMed:8798704)	"[{""reference_id"": ""UniProtKB:P38891"", ""source_assertion"": ""UniProtKB:P38891 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1497/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38891"", ""source_assertion"": ""UniProtKB:P38891 has the exact SGD cross-reference SGD:S000001251."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1497/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38891"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38891 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_location-07b1015cc728_8df41b20d27b	SGD:S000000349	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38113	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38113"", ""source_assertion"": ""UniProtKB:P38113 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3563/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38113"", ""source_assertion"": ""UniProtKB:P38113 has the exact SGD cross-reference SGD:S000000349."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3563/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38113"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38113 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_location-ea1ab3242c76_9b2ca6ca7876	SGD:S000003319	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26263	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/742/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/742/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P26263"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P26263 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_location-7f1495b92dc9_eed9a85ffa50	SGD:S000005446	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00330	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	"[{""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P00330"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00330 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_location-c3e54c00840d_b4c453a95550	SGD:S000003225	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10127	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/302/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/302/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P10127"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P10127 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_location-b80b4f1b750d_2723cf8f5d8d	SGD:S000002327	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32771	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32771"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32771 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_location-091fe2fe90d3_20166a29afa3	SGD:S000002327	RO:0001025	GO:0005739	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32771	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961)	"[{""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 annotates location Mitochondrion (SL-0173)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32771"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32771 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_location-36703d5e93fc_5aa8a4db8b6b	SGD:S000004688	RO:0001025	GO:0005759	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07246	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:1101965); ECO:0000269 (PubMed:2188098); ECO:0000269 (PubMed:2943982)	"[{""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 annotates location Mitochondrion matrix (SL-0170)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_location-b5d74d4cb0f4_ada8e7c3f8e8	SGD:S000004688	RO:0001025	GO:0005743	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07246	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	"[{""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 annotates location Mitochondrion inner membrane (SL-0168)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P07246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_location-5a706de09f76_99741c7ba8e8	SGD:S000003909	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47176	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:21267457); ECO:0000269 (PubMed:8798704)	"[{""reference_id"": ""UniProtKB:P47176"", ""source_assertion"": ""UniProtKB:P47176 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1987/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P47176"", ""source_assertion"": ""UniProtKB:P47176 has the exact SGD cross-reference SGD:S000003909."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1987/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P47176"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47176 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_location-9ea10c14185b_3bb8617d41f8	SGD:S000004124	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16467	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P16467"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16467 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_location-19eb0ec36ddd_f4950da3196d	SGD:S000004124	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16467	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P16467"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16467 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_cofactor-ea44646ed080_782e6d62b2e9	SGD:S000004918	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00331	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	"[{""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/comments/0/cofactors/0; /results/23/comments/0/note""}, {""reference_id"": ""UniProtKB:P00331"", ""source_assertion"": ""UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00331"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00331 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_cofactor-81ce8a7e7be7_7f1bab7f3118	SGD:S000004034	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06169	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10651824) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000269 (PubMed:10651824)	"[{""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/comments/0/cofactors/0; /results/127/comments/0/note""}, {""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P06169"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06169 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_cofactor-5cf6d8babbe2_f85b8e5a54e6	SGD:S000004034	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P06169	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10651824) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000269 (PubMed:10651824)	"[{""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/comments/1/cofactors/0; /results/127/comments/1/note""}, {""reference_id"": ""UniProtKB:P06169"", ""source_assertion"": ""UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P06169"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P06169 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_cofactor-2ed218c0aed2_edf821177079	SGD:S000001251	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38891	UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: Disputed growth phenotypes do not address PLP binding; retain the similarity-based PLP annotation. UniProt evidence: ECO:0000250 (UniProtKB:P0AB80)	"[{""reference_id"": ""UniProtKB:P38891"", ""source_assertion"": ""UniProtKB:P38891 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1497/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P38891"", ""source_assertion"": ""UniProtKB:P38891 has the exact SGD cross-reference SGD:S000001251."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1497/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38891"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38891 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_cofactor-339a304fe175_28ede3918859	SGD:S000000349	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38113	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	"[{""reference_id"": ""UniProtKB:P38113"", ""source_assertion"": ""UniProtKB:P38113 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3563/comments/0/cofactors/0; /results/3563/comments/0/note""}, {""reference_id"": ""UniProtKB:P38113"", ""source_assertion"": ""UniProtKB:P38113 has the exact SGD cross-reference SGD:S000000349."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3563/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P38113"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38113 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_cofactor-437eea628a9f_399817520903	SGD:S000003319	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26263	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/comments/0/cofactors/0; /results/742/comments/0/note""}, {""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P26263"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P26263 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_cofactor-be7459c89012_299e0dc029dc	SGD:S000003319	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P26263	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/comments/1/cofactors/0; /results/742/comments/1/note""}, {""reference_id"": ""UniProtKB:P26263"", ""source_assertion"": ""UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P26263"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P26263 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_cofactor-d020d7cd99ba_78738e30b9df	SGD:S000005446	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P00330	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849)	"[{""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/comments/0/cofactors/0; /results/22/comments/0/note""}, {""reference_id"": ""UniProtKB:P00330"", ""source_assertion"": ""UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P00330"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P00330 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_cofactor-a5e2dcd48dc5_847ac7207443	SGD:S000003225	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10127	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3282541) Zinc. May bind iron when zinc levels are limiting. UniProt note evidence: ECO:0000269 (PubMed:3282541)	"[{""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/comments/0/cofactors/0; /results/302/comments/0/note""}, {""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P10127"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P10127 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_cofactor-ae583f346b28_27d2c942409a	SGD:S000003225	pathwaymech:has_cofactor	CHEBI:29033	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10127	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3282541) Zinc. May bind iron when zinc levels are limiting. UniProt note evidence: ECO:0000269 (PubMed:3282541)	"[{""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 annotates CHEBI:29033 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/comments/0/cofactors/1; /results/302/comments/0/note""}, {""reference_id"": ""UniProtKB:P10127"", ""source_assertion"": ""UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P10127"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P10127 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_cofactor-5ec0450d58bc_61ba30317e28	SGD:S000002327	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32771	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06525) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06525)	"[{""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/990/comments/0/cofactors/0; /results/990/comments/0/note""}, {""reference_id"": ""UniProtKB:P32771"", ""source_assertion"": ""UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/990/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P32771"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32771 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_cofactor-738cd0b35ac6_f2368af31cba	SGD:S000004688	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P07246	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	"[{""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/comments/0/cofactors/0; /results/161/comments/0/note""}, {""reference_id"": ""UniProtKB:P07246"", ""source_assertion"": ""UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P07246"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P07246 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_cofactor-41b7855c2473_c8a7cae5f1e5	SGD:S000003909	pathwaymech:has_cofactor	CHEBI:597326	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P47176	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	"[{""reference_id"": ""UniProtKB:P47176"", ""source_assertion"": ""UniProtKB:P47176 annotates CHEBI:597326 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1987/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P47176"", ""source_assertion"": ""UniProtKB:P47176 has the exact SGD cross-reference SGD:S000003909."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1987/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P47176"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P47176 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_cofactor-93748e431c03_fc9fd66ba562	SGD:S000004124	pathwaymech:has_cofactor	CHEBI:18420	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16467	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 annotates CHEBI:18420 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/comments/0/cofactors/0; /results/439/comments/0/note""}, {""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P16467"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16467 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-4105_cofactor-43ef6e61857d_b30a588a83f9	SGD:S000004124	pathwaymech:has_cofactor	CHEBI:58937	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P16467	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	"[{""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 annotates CHEBI:58937 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/comments/1/cofactors/0; /results/439/comments/1/note""}, {""reference_id"": ""UniProtKB:P16467"", ""source_assertion"": ""UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P16467"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P16467 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-001_075ceb6a0ddc	gomodel:RXN3O-9811	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9811 RO:0002234 gomodel:CHEBI_16526_RXN3O-9811."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/0; endpoint types: /individuals/17/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-002_3d5bc05ac643	SGD:S000000630	pathwaymech:enables	gomodel:RXN3O-9811	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9811 RO:0002333 gomodel:YCR034W-MONOMER_RXN3O-9811_controller."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/1; endpoint types: /individuals/17/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-003_6500356f455c	gomodel:RXN3O-9814	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9814 RO:0002233 gomodel:CHEBI_15378_RXN3O-9814."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/2; endpoint types: /individuals/20/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-005_af3950480847	SGD:S000002173	pathwaymech:enables	gomodel:RXN3O-9814	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9814 RO:0002333 gomodel:MONOMER3O-101_RXN3O-9814_controller."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/4; endpoint types: /individuals/20/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-006_aa3ea438d32f	gomodel:RXN3O-9813	RO:0002411	gomodel:RXN3O-9814	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9813 RO:0002411 gomodel:RXN3O-9814."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/5; endpoint types: /individuals/19/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-007_5d46cc23fb36	gomodel:RXN3O-9813	RO:0002234	CHEBI:50998	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9813 RO:0002234 gomodel:a5c2c59b-7e94-48d3-ba08-123722f9430b_RXN3O-9813."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/6; endpoint types: /individuals/19/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-008_c56eb3f60d39	gomodel:RXN3O-9812	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9812 RO:0002233 gomodel:CHEBI_15378_RXN3O-9812."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/7; endpoint types: /individuals/18/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-009_1dd0f99300cc	gomodel:RXN3O-9811	RO:0002234	CHEBI:15489	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9811 RO:0002234 gomodel:CHEBI_15489_RXN3O-9811."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/8; endpoint types: /individuals/17/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-010_c404b292d4a0	gomodel:RXN3O-9814	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9814 RO:0002233 gomodel:CHEBI_57783_RXN3O-9814."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/9; endpoint types: /individuals/20/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-011_6048f19d02c4	gomodel:RXN3O-9811	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9811 RO:0002234 gomodel:CHEBI_57287_RXN3O-9811."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/10; endpoint types: /individuals/17/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-013_59db16547628	gomodel:RXN3O-9814	RO:0002233	gomodel:46fed9f2-cf0b-4568-b40e-557bd0cfffe5_RXN3O-9813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9814 RO:0002233 gomodel:46fed9f2-cf0b-4568-b40e-557bd0cfffe5_RXN3O-9813."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/12; endpoint types: /individuals/20/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-014_717b98b67401	gomodel:RXN3O-9813	BFO:0000050	GO:0042761	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9813 BFO:0000050 gomodel:YeastPathways_PWY-5080-1/YeastPathways_PWY-5080-1."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/13; endpoint types: /individuals/19/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-015_e74e8afeccca	gomodel:RXN3O-9814	RO:0002234	CHEBI:33184	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9814 RO:0002234 gomodel:CHEBI_33184_RXN3O-9814."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/14; endpoint types: /individuals/20/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-016_a12fe5d1a275	gomodel:RXN3O-9813	RO:0002233	CHEBI:65260	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9813 RO:0002233 gomodel:CHEBI_65260_RXN3O-9812."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/15; endpoint types: /individuals/19/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-017_ab0c51e228a9	SGD:S000000363	pathwaymech:enables	gomodel:RXN3O-9812	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9812 RO:0002333 gomodel:MONOMER3O-79_RXN3O-9812_controller."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/16; endpoint types: /individuals/18/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-018_5c9375cc0d6b	SGD:S000004364	pathwaymech:enables	gomodel:YeastPathways_PWY-5080-1/6a2b236300005423	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5080-1/6a2b236300005423 RO:0002333 gomodel:YeastPathways_PWY-5080-1/6a2b236300005429."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/17; endpoint types: /individuals/56/type; /individuals/61/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-019_1b026c5990b0	gomodel:YeastPathways_PWY-5080-1/6a2b236300005423	BFO:0000050	GO:0042761	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5080-1/6a2b236300005423 BFO:0000050 gomodel:YeastPathways_PWY-5080-1/YeastPathways_PWY-5080-1."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/18; endpoint types: /individuals/56/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-021_e86c05d6a884	gomodel:RXN3O-9811	RO:0002233	CHEBI:33184	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9811 RO:0002233 gomodel:CHEBI_33184_RXN3O-9811."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/20; endpoint types: /individuals/17/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-022_aa886ce37a16	gomodel:RXN3O-9812	RO:0002233	CHEBI:15489	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9812 RO:0002233 gomodel:CHEBI_15489_RXN3O-9811."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/21; endpoint types: /individuals/18/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-023_366cf5c5706f	gomodel:RXN3O-9811	RO:0002233	CHEBI:57384	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9811 RO:0002233 gomodel:CHEBI_57384_RXN3O-9811."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/22; endpoint types: /individuals/17/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-024_5416161df7d2	gomodel:YeastPathways_PWY-5080-1/6a2b236300005423	RO:0002233	CHEBI:33184	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5080-1/6a2b236300005423 RO:0002233 gomodel:YeastPathways_PWY-5080-1/6a2b236300005424."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/23; endpoint types: /individuals/56/type; /individuals/57/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-025_89d7f3613505	gomodel:RXN3O-9811	BFO:0000050	GO:0042761	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9811 BFO:0000050 gomodel:YeastPathways_PWY-5080-1/YeastPathways_PWY-5080-1."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/24; endpoint types: /individuals/17/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-026_975cc550db0d	gomodel:RXN3O-9812	RO:0002234	CHEBI:65260	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9812 RO:0002234 gomodel:CHEBI_65260_RXN3O-9812."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/25; endpoint types: /individuals/18/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-027_a21caa8bd7b8	gomodel:YeastPathways_PWY-5080-1/6a2b236300005423	RO:0002233	CHEBI:57384	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5080-1/6a2b236300005423 RO:0002233 gomodel:YeastPathways_PWY-5080-1/6a2b236300005425."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/26; endpoint types: /individuals/56/type; /individuals/58/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-029_f3c381f31f43	SGD:S000003633	pathwaymech:enables	gomodel:RXN3O-9813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9813 RO:0002333 gomodel:MONOMER3O-85_RXN3O-9813_controller."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/28; endpoint types: /individuals/19/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-031_9bf5c9195a01	gomodel:RXN3O-9814	BFO:0000050	GO:0042761	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9814 BFO:0000050 gomodel:YeastPathways_PWY-5080-1/YeastPathways_PWY-5080-1."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/30; endpoint types: /individuals/20/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-032_70afdf246b34	gomodel:RXN3O-9814	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9814 RO:0002234 gomodel:CHEBI_58349_RXN3O-9814."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/31; endpoint types: /individuals/20/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-033_b96cbe333a28	gomodel:YeastPathways_PWY-5080-1/6a2b236300005423	RO:0002234	CHEBI:57287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5080-1/6a2b236300005423 RO:0002234 gomodel:YeastPathways_PWY-5080-1/6a2b236300005427."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/32; endpoint types: /individuals/56/type; /individuals/60/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-034_0e4183642f91	gomodel:YeastPathways_PWY-5080-1/6a2b236300005423	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5080-1/6a2b236300005423 RO:0002234 gomodel:YeastPathways_PWY-5080-1/6a2b236300005426."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/33; endpoint types: /individuals/56/type; /individuals/59/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-035_d2f31a30a695	gomodel:RXN3O-9812	BFO:0000050	GO:0042761	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9812 BFO:0000050 gomodel:YeastPathways_PWY-5080-1/YeastPathways_PWY-5080-1."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/34; endpoint types: /individuals/18/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-036_490ec7414456	gomodel:RXN3O-9813	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9813 RO:0002234 gomodel:CHEBI_15377_RXN3O-9813."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/35; endpoint types: /individuals/19/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-037_0710fa14df4e	gomodel:YeastPathways_PWY-5080-1/6a2b236300005423	RO:0002234	CHEBI:15489	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:YeastPathways_PWY-5080-1/6a2b236300005423 RO:0002234 gomodel:CHEBI_15489_RXN3O-9811."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/36; endpoint types: /individuals/56/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-038_404ca121b732	gomodel:RXN3O-9812	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9812 RO:0002233 gomodel:CHEBI_57783_RXN3O-9812."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/37; endpoint types: /individuals/18/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_edge-039_ad54c9062493	gomodel:RXN3O-9812	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-5080-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9812 RO:0002234 gomodel:CHEBI_58349_RXN3O-9812."", ""source_locator"": ""./YeastPathways_PWY-5080-1.json#/facts/38; endpoint types: /individuals/18/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-5080-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2026-07-02; member ./YeastPathways_PWY-5080-1.json"", ""title"": ""SGD GO-CAM very long chain fatty acid biosynthesis I - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_location-383f4b4a758c_c7f6a335e19c	SGD:S000000630	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P25358	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12087109); ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:9832547) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P25358"", ""source_assertion"": ""UniProtKB:P25358 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/681/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P25358"", ""source_assertion"": ""UniProtKB:P25358 has the exact SGD cross-reference SGD:S000000630."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/681/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P25358"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P25358 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_location-ab82c4ae55b1_08177f5a1e96	SGD:S000002173	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q99190	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11113186); ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:15958487) Topology: Multi-pass membrane protein. Source qualification: Accumulates at nucleus-vacuole (NV) junctions. Sequestred to NV junctions by NVJ1. Accumulates in nuclear PMN bleps and vesicles during stationary phase and nitrogen starvation	"[{""reference_id"": ""UniProtKB:Q99190"", ""source_assertion"": ""UniProtKB:Q99190 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3182/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q99190"", ""source_assertion"": ""UniProtKB:Q99190 has the exact SGD cross-reference SGD:S000002173."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3182/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q99190"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q99190 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_location-49fa5dd9e9e0_f5c623462d3f	SGD:S000000363	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38286	Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03107); ECO:0000269 (PubMed:23263984) Topology: Single-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P38286"", ""source_assertion"": ""UniProtKB:P38286 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1350/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38286"", ""source_assertion"": ""UniProtKB:P38286 has the exact SGD cross-reference SGD:S000000363."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1350/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38286"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38286 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_location-e557d3c6c6ac_2f1cca0d9658	SGD:S000004364	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40319	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12087109); ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:9832547) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P40319"", ""source_assertion"": ""UniProtKB:P40319 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1690/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P40319"", ""source_assertion"": ""UniProtKB:P40319 has the exact SGD cross-reference SGD:S000004364."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1690/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40319"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40319 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_location-d654f3fb6628_062ac8e876ce	SGD:S000003633	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40857	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:18272525) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P40857"", ""source_assertion"": ""UniProtKB:P40857 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1776/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P40857"", ""source_assertion"": ""UniProtKB:P40857 has the exact SGD cross-reference SGD:S000003633."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1776/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40857"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40857 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_location-6e4cbe25139c_4fd2005bb5b5	SGD:S000003633	RO:0001025	GO:0005774	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40857	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P40857"", ""source_assertion"": ""UniProtKB:P40857 annotates location Vacuole membrane (SL-0271)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1776/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P40857"", ""source_assertion"": ""UniProtKB:P40857 has the exact SGD cross-reference SGD:S000003633."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1776/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40857"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40857 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_location-48f725b5755f_f0d48dbf9ebf	gomodel:RXN3O-9813	BFO:0000066	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P40857	Activity compartment supported by an inspected functional annotation. ECO:0000269 (PubMed:17719544); ECO:0000269 (PubMed:18272525); ECO:0000269 (PubMed:23416297). Alternative isoenzymes may function elsewhere.	"[{""reference_id"": ""UniProtKB:P40857"", ""source_assertion"": ""UniProtKB:P40857 describes the corresponding catalytic function in the endoplasmic reticulum membrane; this projection applies to the activity enabled by SGD:S000003633."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1776/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P40857"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P40857 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-5080-1_location-504f075bdf68_9909cd121c74	gomodel:RXN3O-9814	BFO:0000066	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q99190	Activity compartment supported by an inspected functional annotation. ECO:0000269 (PubMed:11113186); ECO:0000269 (PubMed:15958487). Alternative isoenzymes may function elsewhere.	"[{""reference_id"": ""UniProtKB:Q99190"", ""source_assertion"": ""UniProtKB:Q99190 describes the corresponding catalytic function in the endoplasmic reticulum membrane; this projection applies to the activity enabled by SGD:S000002173."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3182/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q99190"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q99190 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_edge-001_bf096be17f08	gomodel:RXN-8773	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-8		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_assertion"": ""The model asserts gomodel:RXN-8773 RO:0002233 gomodel:CHEBI_57783_RXN-8773."", ""source_locator"": ""./YeastPathways_PWY3O-8.json#/facts/0; endpoint types: /individuals/10/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-8.json"", ""title"": ""SGD GO-CAM xylose metabolism - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_edge-002_5ca3778e23f6	SGD:S000004060	pathwaymech:enables	gomodel:D-XYLULOSE-REDUCTASE-RXN	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-8		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_assertion"": ""The model asserts gomodel:D-XYLULOSE-REDUCTASE-RXN RO:0002333 gomodel:YLR070C-MONOMER_D-XYLULOSE-REDUCTASE-RXN_controller."", ""source_locator"": ""./YeastPathways_PWY3O-8.json#/facts/1; endpoint types: /individuals/9/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-8.json"", ""title"": ""SGD GO-CAM xylose metabolism - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_edge-003_6e5adaf9efe8	gomodel:RXN-8773	RO:0002233	CHEBI:53455	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-8		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_assertion"": ""The model asserts gomodel:RXN-8773 RO:0002233 gomodel:CHEBI_53455_RXN-8773."", ""source_locator"": ""./YeastPathways_PWY3O-8.json#/facts/2; endpoint types: /individuals/10/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-8.json"", ""title"": ""SGD GO-CAM xylose metabolism - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_edge-004_746e6c5c0eb8	gomodel:D-XYLULOSE-REDUCTASE-RXN	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-8		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_assertion"": ""The model asserts gomodel:D-XYLULOSE-REDUCTASE-RXN BFO:0000066 gomodel:reaction_D-XYLULOSE-REDUCTASE-RXN_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-8.json#/facts/3; endpoint types: /individuals/9/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-8.json"", ""title"": ""SGD GO-CAM xylose metabolism - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_edge-005_2ce9a6b92682	gomodel:D-XYLULOSE-REDUCTASE-RXN	BFO:0000050	GO:0042732	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-8		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_assertion"": ""The model asserts gomodel:D-XYLULOSE-REDUCTASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-8/YeastPathways_PWY3O-8."", ""source_locator"": ""./YeastPathways_PWY3O-8.json#/facts/4; endpoint types: /individuals/9/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-8.json"", ""title"": ""SGD GO-CAM xylose metabolism - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_edge-006_86e8f8f4e7bb	SGD:S000001146	pathwaymech:enables	gomodel:RXN-8773	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-8		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_assertion"": ""The model asserts gomodel:RXN-8773 RO:0002333 gomodel:YHR104W-MONOMER_RXN-8773_controller."", ""source_locator"": ""./YeastPathways_PWY3O-8.json#/facts/5; endpoint types: /individuals/10/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-8.json"", ""title"": ""SGD GO-CAM xylose metabolism - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_edge-007_5779a2f13662	gomodel:D-XYLULOSE-REDUCTASE-RXN	RO:0002233	CHEBI:17151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-8		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_assertion"": ""The model asserts gomodel:D-XYLULOSE-REDUCTASE-RXN RO:0002233 gomodel:CHEBI_17151_RXN-8773."", ""source_locator"": ""./YeastPathways_PWY3O-8.json#/facts/6; endpoint types: /individuals/9/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-8.json"", ""title"": ""SGD GO-CAM xylose metabolism - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_edge-008_b6e3ff1e66d5	gomodel:RXN-8773	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-8		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_assertion"": ""The model asserts gomodel:RXN-8773 RO:0002233 gomodel:CHEBI_15378_RXN-8773."", ""source_locator"": ""./YeastPathways_PWY3O-8.json#/facts/7; endpoint types: /individuals/10/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-8.json"", ""title"": ""SGD GO-CAM xylose metabolism - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_edge-009_aec3103da7e5	gomodel:D-XYLULOSE-REDUCTASE-RXN	RO:0002234	CHEBI:57945	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-8		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_assertion"": ""The model asserts gomodel:D-XYLULOSE-REDUCTASE-RXN RO:0002234 gomodel:CHEBI_57945_D-XYLULOSE-REDUCTASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-8.json#/facts/8; endpoint types: /individuals/9/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-8.json"", ""title"": ""SGD GO-CAM xylose metabolism - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_edge-010_c3c635c125c5	gomodel:D-XYLULOSE-REDUCTASE-RXN	RO:0002234	CHEBI:17140	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-8		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_assertion"": ""The model asserts gomodel:D-XYLULOSE-REDUCTASE-RXN RO:0002234 gomodel:CHEBI_17140_D-XYLULOSE-REDUCTASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-8.json#/facts/9; endpoint types: /individuals/9/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-8.json"", ""title"": ""SGD GO-CAM xylose metabolism - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_edge-011_f4df80a184c3	gomodel:D-XYLULOSE-REDUCTASE-RXN	RO:0002234	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-8		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_assertion"": ""The model asserts gomodel:D-XYLULOSE-REDUCTASE-RXN RO:0002234 gomodel:CHEBI_15378_D-XYLULOSE-REDUCTASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-8.json#/facts/10; endpoint types: /individuals/9/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-8.json"", ""title"": ""SGD GO-CAM xylose metabolism - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_edge-012_86b76828348f	gomodel:RXN-8773	BFO:0000050	GO:0042732	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-8		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_assertion"": ""The model asserts gomodel:RXN-8773 BFO:0000050 gomodel:YeastPathways_PWY3O-8/YeastPathways_PWY3O-8."", ""source_locator"": ""./YeastPathways_PWY3O-8.json#/facts/11; endpoint types: /individuals/10/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-8.json"", ""title"": ""SGD GO-CAM xylose metabolism - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_edge-013_8c1f6f095544	gomodel:RXN-8773	BFO:0000066	GO:0005829	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-8		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_assertion"": ""The model asserts gomodel:RXN-8773 BFO:0000066 gomodel:reaction_RXN-8773_location_lociGO_0005829."", ""source_locator"": ""./YeastPathways_PWY3O-8.json#/facts/12; endpoint types: /individuals/10/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-8.json"", ""title"": ""SGD GO-CAM xylose metabolism - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_edge-014_7f09105ce740	gomodel:RXN-8773	RO:0002234	CHEBI:17151	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-8		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_assertion"": ""The model asserts gomodel:RXN-8773 RO:0002234 gomodel:CHEBI_17151_RXN-8773."", ""source_locator"": ""./YeastPathways_PWY3O-8.json#/facts/13; endpoint types: /individuals/10/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-8.json"", ""title"": ""SGD GO-CAM xylose metabolism - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_edge-015_b9229723561b	gomodel:D-XYLULOSE-REDUCTASE-RXN	RO:0002233	CHEBI:57540	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-8		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_assertion"": ""The model asserts gomodel:D-XYLULOSE-REDUCTASE-RXN RO:0002233 gomodel:CHEBI_57540_D-XYLULOSE-REDUCTASE-RXN."", ""source_locator"": ""./YeastPathways_PWY3O-8.json#/facts/14; endpoint types: /individuals/9/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-8.json"", ""title"": ""SGD GO-CAM xylose metabolism - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_edge-016_ce817c48c38f	gomodel:RXN-8773	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY3O-8		"[{""reference_id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_assertion"": ""The model asserts gomodel:RXN-8773 RO:0002234 gomodel:CHEBI_58349_RXN-8773."", ""source_locator"": ""./YeastPathways_PWY3O-8.json#/facts/15; endpoint types: /individuals/10/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY3O-8"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_PWY3O-8.json"", ""title"": ""SGD GO-CAM xylose metabolism - imported from: Saccharomyces Genome Database"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_location-6aa4c935b5e1_b5b7ec544420	SGD:S000001146	RO:0001025	GO:0005737	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38715	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38715"", ""source_assertion"": ""UniProtKB:P38715 annotates location Cytoplasm (SL-0086)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1421/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38715"", ""source_assertion"": ""UniProtKB:P38715 has the exact SGD cross-reference SGD:S000001146."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1421/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38715"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38715 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_location-ac22ef3cd0b1_243e582acc16	SGD:S000001146	RO:0001025	GO:0005634	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P38715	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	"[{""reference_id"": ""UniProtKB:P38715"", ""source_assertion"": ""UniProtKB:P38715 annotates location Nucleus (SL-0191)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1421/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P38715"", ""source_assertion"": ""UniProtKB:P38715 has the exact SGD cross-reference SGD:S000001146."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1421/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P38715"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P38715 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY3O-8_cofactor-0dc40bfc7f52_8926aacf5e3d	SGD:S000004060	pathwaymech:has_cofactor	CHEBI:29105	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q07993	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 zinc ion per subunit. UniProt note evidence: ECO:0000250	"[{""reference_id"": ""UniProtKB:Q07993"", ""source_assertion"": ""UniProtKB:Q07993 annotates CHEBI:29105 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/5004/comments/0/cofactors/0; /results/5004/comments/0/note""}, {""reference_id"": ""UniProtKB:Q07993"", ""source_assertion"": ""UniProtKB:Q07993 has the exact SGD cross-reference SGD:S000004060."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/5004/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:Q07993"", ""source_sha256"": ""1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4"", ""source_version"": ""2026_03"", ""title"": ""UniProtKB Q07993 cofactor annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-001_ebb6ffaefa78	SGD:S000003292	pathwaymech:enables	gomodel:RXN3O-9826	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9826 RO:0002333 gomodel:YGR060W-MONOMER_RXN3O-9826_controller."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/0; endpoint types: /individuals/62/type; /individuals/75/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-002_181d2c9cc703	gomodel:RXN3O-9822	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9822 RO:0002234 gomodel:CHEBI_15377_RXN3O-9822."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/1; endpoint types: /individuals/58/type; /individuals/20/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-003_5a1062a09186	gomodel:RXN66-314	BFO:0000050	GO:0036197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-314 BFO:0000050 gomodel:YeastPathways_PWY-6074-1/YeastPathways_PWY-6074-1."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/2; endpoint types: /individuals/65/type; /individuals/186/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-004_372814b2b14c	gomodel:RXN3O-9823	BFO:0000050	GO:0036197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9823 BFO:0000050 gomodel:YeastPathways_PWY-6074-1/YeastPathways_PWY-6074-1."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/3; endpoint types: /individuals/59/type; /individuals/186/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-005_386878ef4612	SGD:S000001049	pathwaymech:enables	gomodel:RXN3O-9820	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9820 RO:0002333 gomodel:YHR007C-MONOMER_RXN3O-9820_controller."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/4; endpoint types: /individuals/56/type; /individuals/76/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-006_15e580d4875d	gomodel:RXN3O-9820	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9820 RO:0002233 gomodel:CHEBI_15378_RXN3O-9820."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/5; endpoint types: /individuals/56/type; /individuals/25/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-007_4d7662613f37	gomodel:RXN3O-9823	RO:0002233	CHEBI:13392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9823 RO:0002233 gomodel:CHEBI_13392_RXN3O-9823."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/6; endpoint types: /individuals/59/type; /individuals/8/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-008_c30e17ec78b5	gomodel:RXN66-306	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-306 RO:0002234 gomodel:CHEBI_58349_RXN66-306."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/7; endpoint types: /individuals/63/type; /individuals/50/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-010_213f284d4826	gomodel:RXN66-319	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-319 RO:0002233 gomodel:CHEBI_15378_RXN66-319."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/9; endpoint types: /individuals/67/type; /individuals/28/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-011_dbfc70dda018	gomodel:RXN66-319	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-319 RO:0002233 gomodel:CHEBI_57783_RXN66-319."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/10; endpoint types: /individuals/67/type; /individuals/48/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-012_79dede9069e1	gomodel:RXN66-313	RO:0002234	CHEBI:13392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-313 RO:0002234 gomodel:CHEBI_13392_RXN66-313."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/11; endpoint types: /individuals/64/type; /individuals/12/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-013_afe5fdaa97c8	gomodel:RXN3O-9825	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9825 RO:0002234 gomodel:CHEBI_15377_RXN3O-9825."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/12; endpoint types: /individuals/61/type; /individuals/23/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-014_e767697f885a	gomodel:RXN3O-9820	RO:0002234	CHEBI:17813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9820 RO:0002234 gomodel:CHEBI_17813_RXN3O-9820."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/13; endpoint types: /individuals/56/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-016_664330f3c15c	gomodel:RXN3O-9822	BFO:0000050	GO:0036197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9822 BFO:0000050 gomodel:YeastPathways_PWY-6074-1/YeastPathways_PWY-6074-1."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/15; endpoint types: /individuals/58/type; /individuals/186/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-017_392a629f322e	gomodel:RXN66-319	RO:0002233	CHEBI:52386	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-319 RO:0002233 gomodel:CHEBI_52386_RXN66-318."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/16; endpoint types: /individuals/67/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-019_a2a582468f79	gomodel:RXN66-314	RO:0002233	CHEBI:136486	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-314 RO:0002233 gomodel:CHEBI_136486_RXN66-313."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/18; endpoint types: /individuals/65/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-020_8468aa0150e0	gomodel:RXN3O-9826	RO:0002234	CHEBI:13390	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9826 RO:0002234 gomodel:CHEBI_13390_RXN3O-9826."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/19; endpoint types: /individuals/62/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-021_32278126fc1b	gomodel:RXN3O-9825	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9825 RO:0002233 gomodel:CHEBI_15379_RXN3O-9825."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/20; endpoint types: /individuals/61/type; /individuals/34/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-022_af80e3c64643	gomodel:RXN3O-9821	RO:0002234	CHEBI:13390	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9821 RO:0002234 gomodel:CHEBI_13390_RXN3O-9821."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/21; endpoint types: /individuals/57/type; /individuals/0/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-023_e4271c57c653	gomodel:RXN3O-9820	RO:0002234	CHEBI:15740	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9820 RO:0002234 gomodel:CHEBI_15740_RXN3O-9820."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/22; endpoint types: /individuals/56/type; /individuals/36/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-024_021740e1e53c	gomodel:RXN66-314	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-314 RO:0002233 gomodel:CHEBI_57783_RXN66-314."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/23; endpoint types: /individuals/65/type; /individuals/47/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-025_f30932e3601c	gomodel:RXN3O-9822	RO:0002233	CHEBI:87289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9822 RO:0002233 gomodel:CHEBI_87289_RXN3O-9821."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/24; endpoint types: /individuals/58/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-027_3c4e49a6b4a9	SGD:S000003292	pathwaymech:enables	gomodel:RXN3O-9821	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9821 RO:0002333 gomodel:YGR060W-MONOMER_RXN3O-9821_controller."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/26; endpoint types: /individuals/57/type; /individuals/70/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-028_f7b41702721a	gomodel:RXN3O-9821	BFO:0000050	GO:0036197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9821 BFO:0000050 gomodel:YeastPathways_PWY-6074-1/YeastPathways_PWY-6074-1."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/27; endpoint types: /individuals/57/type; /individuals/186/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-029_355f1e213e71	SGD:S000004090	pathwaymech:enables	gomodel:RXN66-314	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-314 RO:0002333 gomodel:YLR100W-MONOMER_RXN66-314_controller."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/28; endpoint types: /individuals/65/type; /individuals/77/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-030_d12cf2fc56f2	gomodel:RXN3O-9825	RO:0002233	CHEBI:13392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9825 RO:0002233 gomodel:CHEBI_13392_RXN3O-9825."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/29; endpoint types: /individuals/61/type; /individuals/10/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-031_8026275fc874	gomodel:RXN3O-9824	RO:0002234	CHEBI:13390	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9824 RO:0002234 gomodel:CHEBI_13390_RXN3O-9824."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/30; endpoint types: /individuals/60/type; /individuals/3/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-033_4f58cb01be42	gomodel:RXN3O-9824	BFO:0000050	GO:0036197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9824 BFO:0000050 gomodel:YeastPathways_PWY-6074-1/YeastPathways_PWY-6074-1."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/32; endpoint types: /individuals/60/type; /individuals/186/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-034_d1ccaaec3fa8	gomodel:RXN66-319	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-319 RO:0002234 gomodel:CHEBI_58349_RXN66-319."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/33; endpoint types: /individuals/67/type; /individuals/52/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-036_c4b5163ed743	gomodel:RXN3O-9824	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9824 RO:0002233 gomodel:CHEBI_15379_RXN3O-9824."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/35; endpoint types: /individuals/60/type; /individuals/33/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-037_7b23c9776d5a	gomodel:RXN66-313	BFO:0000050	GO:0036197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-313 BFO:0000050 gomodel:YeastPathways_PWY-6074-1/YeastPathways_PWY-6074-1."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/36; endpoint types: /individuals/64/type; /individuals/186/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-038_e2f6e6f31e8e	gomodel:RXN3O-9822	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9822 RO:0002233 gomodel:CHEBI_15379_RXN3O-9822."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/37; endpoint types: /individuals/58/type; /individuals/31/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-039_4477f67b1ebe	SGD:S000004090	pathwaymech:enables	gomodel:RXN66-319	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-319 RO:0002333 gomodel:YLR100W-MONOMER_RXN66-319_controller."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/38; endpoint types: /individuals/67/type; /individuals/78/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-040_1d22fe388a4d	gomodel:RXN3O-9821	RO:0002234	CHEBI:87289	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9821 RO:0002234 gomodel:CHEBI_87289_RXN3O-9821."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/39; endpoint types: /individuals/57/type; /individuals/55/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-041_63a97a7f9e44	SGD:S000003292	pathwaymech:enables	gomodel:RXN3O-9824	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9824 RO:0002333 gomodel:YGR060W-MONOMER_RXN3O-9824_controller."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/40; endpoint types: /individuals/60/type; /individuals/73/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-042_9e64ab119be4	gomodel:RXN3O-9821	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9821 RO:0002234 gomodel:CHEBI_15377_RXN3O-9821."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/41; endpoint types: /individuals/57/type; /individuals/19/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-043_e15bd24642be	gomodel:RXN3O-9824	RO:0002233	CHEBI:1949	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9824 RO:0002233 gomodel:CHEBI_1949_RXN66-314."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/42; endpoint types: /individuals/60/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-046_4b48553714aa	SGD:S000005224	pathwaymech:enables	gomodel:RXN66-306	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-306 RO:0002333 gomodel:YNL280C-MONOMER_RXN66-306_controller."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/45; endpoint types: /individuals/63/type; /individuals/79/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-047_b7cd33de7486	gomodel:RXN3O-9821	RO:0002233	CHEBI:18364	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9821 RO:0002233 gomodel:CHEBI_18364_RXN66-306."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/46; endpoint types: /individuals/57/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-048_d59dcfac9960	gomodel:RXN66-318	BFO:0000050	GO:0036197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-318 BFO:0000050 gomodel:YeastPathways_PWY-6074-1/YeastPathways_PWY-6074-1."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/47; endpoint types: /individuals/66/type; /individuals/186/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-049_47736d2f8bda	gomodel:RXN3O-9826	RO:0002234	CHEBI:143575	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9826 RO:0002234 gomodel:CHEBI_143575_RXN3O-9826."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/48; endpoint types: /individuals/62/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-050_d9185ce1be76	gomodel:RXN66-306	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-306 RO:0002233 gomodel:CHEBI_57783_RXN66-306."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/49; endpoint types: /individuals/63/type; /individuals/46/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-051_36a54aa0f2f1	gomodel:RXN3O-9825	RO:0002233	CHEBI:146130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9825 RO:0002233 gomodel:CHEBI_146130_RXN3O-9824."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/50; endpoint types: /individuals/61/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-052_28cf7e5c8c22	gomodel:RXN3O-9820	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9820 RO:0002234 gomodel:CHEBI_58349_RXN3O-9820."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/51; endpoint types: /individuals/56/type; /individuals/49/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-053_7c7bb1062f86	gomodel:RXN3O-9825	RO:0002234	CHEBI:146131	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9825 RO:0002234 gomodel:CHEBI_146131_RXN3O-9825."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/52; endpoint types: /individuals/61/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-054_945f88f9fe47	gomodel:RXN3O-9823	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9823 RO:0002233 gomodel:CHEBI_15379_RXN3O-9823."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/53; endpoint types: /individuals/59/type; /individuals/32/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-055_c342dce1bfb2	gomodel:RXN66-318	RO:0002234	CHEBI:13392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-318 RO:0002234 gomodel:CHEBI_13392_RXN66-318."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/54; endpoint types: /individuals/66/type; /individuals/13/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-057_5fb5754827bf	gomodel:RXN3O-9826	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9826 RO:0002234 gomodel:CHEBI_15377_RXN3O-9826."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/56; endpoint types: /individuals/62/type; /individuals/24/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-058_b03354cec56c	gomodel:RXN3O-9822	RO:0002234	CHEBI:13390	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9822 RO:0002234 gomodel:CHEBI_13390_RXN3O-9822."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/57; endpoint types: /individuals/58/type; /individuals/1/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-059_36c0fcf13c79	gomodel:RXN3O-9826	BFO:0000050	GO:0036197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9826 BFO:0000050 gomodel:YeastPathways_PWY-6074-1/YeastPathways_PWY-6074-1."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/58; endpoint types: /individuals/62/type; /individuals/186/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-060_cd71a3963173	gomodel:RXN66-318	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-318 RO:0002234 gomodel:CHEBI_16526_RXN66-318."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/59; endpoint types: /individuals/66/type; /individuals/39/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-062_e726151b9ca3	SGD:S000002969	pathwaymech:enables	gomodel:RXN66-313	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-313 RO:0002333 gomodel:YGL001C-MONOMER_RXN66-313_controller."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/61; endpoint types: /individuals/64/type; /individuals/68/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-063_ac49c5b3bfb9	gomodel:RXN3O-9823	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9823 RO:0002234 gomodel:CHEBI_15377_RXN3O-9823."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/62; endpoint types: /individuals/59/type; /individuals/21/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-064_a654ffb6fbf8	gomodel:RXN3O-9820	RO:0002233	CHEBI:57783	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9820 RO:0002233 gomodel:CHEBI_57783_RXN3O-9820."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/63; endpoint types: /individuals/56/type; /individuals/45/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-065_a876804d1164	gomodel:RXN3O-9820	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9820 RO:0002233 gomodel:CHEBI_15379_RXN3O-9820."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/64; endpoint types: /individuals/56/type; /individuals/29/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-066_deb1db9b76b0	gomodel:RXN3O-9826	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9826 RO:0002233 gomodel:CHEBI_15379_RXN3O-9826."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/65; endpoint types: /individuals/62/type; /individuals/35/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-067_01a6bc7a0fde	SGD:S000003292	pathwaymech:enables	gomodel:RXN3O-9823	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9823 RO:0002333 gomodel:YGR060W-MONOMER_RXN3O-9823_controller."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/66; endpoint types: /individuals/59/type; /individuals/72/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-068_2aa5bda23b40	gomodel:RXN3O-9822	RO:0002233	CHEBI:13392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9822 RO:0002233 gomodel:CHEBI_13392_RXN3O-9822."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/67; endpoint types: /individuals/58/type; /individuals/7/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-069_d7697cba9d9c	gomodel:RXN3O-9822	RO:0002411	gomodel:RXN3O-9822	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9822 RO:0002411 gomodel:RXN3O-9822."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/68; endpoint types: /individuals/58/type; /individuals/58/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-070_889452b1959d	SGD:S000003292	pathwaymech:enables	gomodel:RXN3O-9825	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9825 RO:0002333 gomodel:YGR060W-MONOMER_RXN3O-9825_controller."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/69; endpoint types: /individuals/61/type; /individuals/74/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-071_a9e2f18ebc82	gomodel:RXN3O-9821	RO:0002233	CHEBI:15379	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9821 RO:0002233 gomodel:CHEBI_15379_RXN3O-9821."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/70; endpoint types: /individuals/57/type; /individuals/30/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-072_5028940016a6	gomodel:RXN3O-9824	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9824 RO:0002234 gomodel:CHEBI_15377_RXN3O-9824."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/71; endpoint types: /individuals/60/type; /individuals/22/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-073_12680f50c178	gomodel:RXN66-313	RO:0002233	CHEBI:64925	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-313 RO:0002233 gomodel:CHEBI_64925_RXN3O-9823."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/72; endpoint types: /individuals/64/type; /individuals/53/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-074_0b1d47e5f0e0	gomodel:RXN3O-9820	RO:0002234	CHEBI:15377	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9820 RO:0002234 gomodel:CHEBI_15377_RXN3O-9820."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/73; endpoint types: /individuals/56/type; /individuals/18/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-075_4d854553d470	gomodel:RXN66-318	RO:0002234	CHEBI:52386	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-318 RO:0002234 gomodel:CHEBI_52386_RXN66-318."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/74; endpoint types: /individuals/66/type; /individuals/44/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-076_30098db02a95	gomodel:RXN3O-9823	RO:0002234	CHEBI:64925	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9823 RO:0002234 gomodel:CHEBI_64925_RXN3O-9823."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/75; endpoint types: /individuals/59/type; /individuals/53/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-077_ee6461d01258	gomodel:RXN3O-9823	RO:0002233	CHEBI:87287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9823 RO:0002233 gomodel:CHEBI_87287_RXN3O-9822."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/76; endpoint types: /individuals/59/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-078_1787ca9c46c0	gomodel:RXN66-314	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-314 RO:0002233 gomodel:CHEBI_15378_RXN66-314."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/77; endpoint types: /individuals/65/type; /individuals/27/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-079_2ec49845017f	gomodel:RXN66-314	RO:0002234	CHEBI:1949	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-314 RO:0002234 gomodel:CHEBI_1949_RXN66-314."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/78; endpoint types: /individuals/65/type; /individuals/43/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-080_7eb8abd2d8a6	gomodel:RXN3O-9820	RO:0002233	CHEBI:16521	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9820 RO:0002233 gomodel:CHEBI_16521_RXN3O-9820."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/79; endpoint types: /individuals/56/type; /individuals/37/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-081_8cc0cd908f5c	gomodel:RXN3O-9825	RO:0002234	CHEBI:13390	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9825 RO:0002234 gomodel:CHEBI_13390_RXN3O-9825."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/80; endpoint types: /individuals/61/type; /individuals/4/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-082_190609b10207	gomodel:RXN66-318	RO:0002233	CHEBI:143575	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-318 RO:0002233 gomodel:CHEBI_143575_RXN3O-9826."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/81; endpoint types: /individuals/66/type; /individuals/15/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-083_df242a072953	gomodel:RXN3O-9821	RO:0002233	CHEBI:13392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9821 RO:0002233 gomodel:CHEBI_13392_RXN3O-9821."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/82; endpoint types: /individuals/57/type; /individuals/6/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-084_e6f5eebc63ab	gomodel:RXN3O-9826	RO:0002233	CHEBI:146131	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9826 RO:0002233 gomodel:CHEBI_146131_RXN3O-9825."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/83; endpoint types: /individuals/62/type; /individuals/17/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-085_baa74633f5b0	gomodel:RXN3O-9826	RO:0002233	CHEBI:13392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9826 RO:0002233 gomodel:CHEBI_13392_RXN3O-9826."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/84; endpoint types: /individuals/62/type; /individuals/11/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-086_4ea3e0ebb89e	gomodel:RXN66-314	RO:0002234	CHEBI:58349	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-314 RO:0002234 gomodel:CHEBI_58349_RXN66-314."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/85; endpoint types: /individuals/65/type; /individuals/51/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-088_05a86ce13520	gomodel:RXN66-319	BFO:0000050	GO:0036197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-319 BFO:0000050 gomodel:YeastPathways_PWY-6074-1/YeastPathways_PWY-6074-1."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/87; endpoint types: /individuals/67/type; /individuals/186/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-089_bf7624841255	gomodel:RXN66-306	BFO:0000050	GO:0036197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-306 BFO:0000050 gomodel:YeastPathways_PWY-6074-1/YeastPathways_PWY-6074-1."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/88; endpoint types: /individuals/63/type; /individuals/186/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-090_0db92de8ef21	SGD:S000003292	pathwaymech:enables	gomodel:RXN3O-9822	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9822 RO:0002333 gomodel:YGR060W-MONOMER_RXN3O-9822_controller."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/89; endpoint types: /individuals/58/type; /individuals/71/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-091_467aa2622abf	gomodel:RXN66-306	RO:0002234	CHEBI:18364	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-306 RO:0002234 gomodel:CHEBI_18364_RXN66-306."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/90; endpoint types: /individuals/63/type; /individuals/42/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-092_870b90bd8bdb	gomodel:RXN66-318	RO:0002233	CHEBI:13390	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-318 RO:0002233 gomodel:CHEBI_13390_RXN3O-9826."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/91; endpoint types: /individuals/66/type; /individuals/5/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-093_b04a5db6f168	gomodel:RXN66-313	RO:0002233	CHEBI:13390	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-313 RO:0002233 gomodel:CHEBI_13390_RXN3O-9823."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/92; endpoint types: /individuals/64/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-094_78a84fee60e2	SGD:S000002969	pathwaymech:enables	gomodel:RXN66-318	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-318 RO:0002333 gomodel:YGL001C-MONOMER_RXN66-318_controller."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/93; endpoint types: /individuals/66/type; /individuals/69/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-095_a6c02d891cf1	gomodel:RXN3O-9820	BFO:0000050	GO:0036197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9820 BFO:0000050 gomodel:YeastPathways_PWY-6074-1/YeastPathways_PWY-6074-1."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/94; endpoint types: /individuals/56/type; /individuals/186/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-096_c57ee4c161a7	gomodel:RXN66-306	RO:0002233	CHEBI:17813	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-306 RO:0002233 gomodel:CHEBI_17813_RXN3O-9820."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/95; endpoint types: /individuals/63/type; /individuals/40/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-097_741f8f9c3f8b	gomodel:RXN3O-9823	RO:0002234	CHEBI:13390	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9823 RO:0002234 gomodel:CHEBI_13390_RXN3O-9823."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/96; endpoint types: /individuals/59/type; /individuals/2/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-098_6f160c84c31e	gomodel:RXN3O-9824	RO:0002234	CHEBI:146130	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9824 RO:0002234 gomodel:CHEBI_146130_RXN3O-9824."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/97; endpoint types: /individuals/60/type; /individuals/16/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-099_18674eb2533f	gomodel:RXN3O-9825	BFO:0000050	GO:0036197	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9825 BFO:0000050 gomodel:YeastPathways_PWY-6074-1/YeastPathways_PWY-6074-1."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/98; endpoint types: /individuals/61/type; /individuals/186/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-100_a15b9edab365	gomodel:RXN66-313	RO:0002234	CHEBI:16526	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-313 RO:0002234 gomodel:CHEBI_16526_RXN66-313."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/99; endpoint types: /individuals/64/type; /individuals/38/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-101_77e12f58b4c1	gomodel:RXN66-313	RO:0002234	CHEBI:136486	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-313 RO:0002234 gomodel:CHEBI_136486_RXN66-313."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/100; endpoint types: /individuals/64/type; /individuals/14/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-102_d680bca2f253	gomodel:RXN66-306	RO:0002233	CHEBI:15378	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-306 RO:0002233 gomodel:CHEBI_15378_RXN66-306."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/101; endpoint types: /individuals/63/type; /individuals/26/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-103_c4a1046a5767	gomodel:RXN3O-9822	RO:0002234	CHEBI:87287	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9822 RO:0002234 gomodel:CHEBI_87287_RXN3O-9822."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/102; endpoint types: /individuals/58/type; /individuals/54/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-104_e91d305e6bb0	gomodel:RXN3O-9824	RO:0002233	CHEBI:13392	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN3O-9824 RO:0002233 gomodel:CHEBI_13392_RXN3O-9824."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/103; endpoint types: /individuals/60/type; /individuals/9/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_edge-105_e22d0f46758d	gomodel:RXN66-319	RO:0002234	CHEBI:18252	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	gomodel:YeastPathways_PWY-6074-1		"[{""reference_id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_assertion"": ""The model asserts gomodel:RXN66-319 RO:0002234 gomodel:CHEBI_18252_RXN66-319."", ""source_locator"": ""./YeastPathways_PWY-6074-1.json#/facts/104; endpoint types: /individuals/67/type; /individuals/41/type""}]"	"[{""id"": ""gomodel:YeastPathways_PWY-6074-1"", ""source_sha256"": ""7a6999245e9265f2167d6e47c7565adb17433ad26611f1a877dc79564279523b"", ""source_version"": ""Pinned Noctua JSON archive; model date 2024-09-12; member ./YeastPathways_PWY-6074-1.json"", ""title"": ""GO-CAM zymosterol biosynthesis model YeastPathways_PWY-6074-1"", ""url"": ""https://current.geneontology.org/products/json/noctua-models-json.tgz""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_location-756594378cc9_6161014e782c	SGD:S000003292	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53045	Physical protein location from reviewed UniProt. ECO:0000305 (PubMed:12119386); ECO:0000305 (PubMed:15716577); ECO:0000305 (PubMed:8663358) Topology: Single-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P53045"", ""source_assertion"": ""UniProtKB:P53045 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2096/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53045"", ""source_assertion"": ""UniProtKB:P53045 has the exact SGD cross-reference SGD:S000003292."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2096/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53045"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53045 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_location-6a836889d6a4_98857e2b368d	SGD:S000001049	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10614	Physical protein location from reviewed UniProt. ECO:0000305 Topology: Single-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P10614"", ""source_assertion"": ""UniProtKB:P10614 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/308/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P10614"", ""source_assertion"": ""UniProtKB:P10614 has the exact SGD cross-reference SGD:S000001049."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/308/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P10614"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P10614 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_location-d5dd1400a98b_5f69b274f90b	SGD:S000004090	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12452	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12119386); ECO:0000269 (PubMed:12842197); ECO:0000269 (PubMed:15716577) Topology: Peripheral membrane protein.	"[{""reference_id"": ""UniProtKB:Q12452"", ""source_assertion"": ""UniProtKB:Q12452 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3106/comments/2/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q12452"", ""source_assertion"": ""UniProtKB:Q12452 has the exact SGD cross-reference SGD:S000004090."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3106/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q12452"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12452 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_location-2f7197fc267e_d822df04c3c0	SGD:S000004090	RO:0001025	GO:0005811	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:Q12452	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12119386); ECO:0000269 (PubMed:12842197); ECO:0000269 (PubMed:15716577)	"[{""reference_id"": ""UniProtKB:Q12452"", ""source_assertion"": ""UniProtKB:Q12452 annotates location Lipid droplet (SL-0154)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3106/comments/2/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:Q12452"", ""source_assertion"": ""UniProtKB:Q12452 has the exact SGD cross-reference SGD:S000004090."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3106/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:Q12452"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB Q12452 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_location-291fa266c067_883515dfdf68	SGD:S000005224	RO:0001025	GO:0016020	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P32462	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16847258) Topology: Multi-pass membrane protein.	"[{""reference_id"": ""UniProtKB:P32462"", ""source_assertion"": ""UniProtKB:P32462 annotates location Membrane (SL-0162)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/909/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P32462"", ""source_assertion"": ""UniProtKB:P32462 has the exact SGD cross-reference SGD:S000005224."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/909/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P32462"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P32462 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_location-ec5b153a6ec5_0e0103c8b4ee	SGD:S000002969	RO:0001025	GO:0005789	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53199	Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11279045); ECO:0000269 (PubMed:12119386); ECO:0000269 (PubMed:15716577) Topology: Peripheral membrane protein.	"[{""reference_id"": ""UniProtKB:P53199"", ""source_assertion"": ""UniProtKB:P53199 annotates location Endoplasmic reticulum membrane (SL-0097)."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2156/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}, {""reference_id"": ""UniProtKB:P53199"", ""source_assertion"": ""UniProtKB:P53199 has the exact SGD cross-reference SGD:S000002969."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2156/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d""}]"	"[{""id"": ""UniProtKB:P53199"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53199 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_cofactor-3cc598cf9106_4af1e9e21712	SGD:S000003292	pathwaymech:has_cofactor	CHEBI:24875	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P53045	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:8663358)	"[{""reference_id"": ""UniProtKB:P53045"", ""source_assertion"": ""UniProtKB:P53045 annotates CHEBI:24875 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2096/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P53045"", ""source_assertion"": ""UniProtKB:P53045 has the exact SGD cross-reference SGD:S000003292."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2096/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P53045"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P53045 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""
pathwaymech:gomodel_YeastPathways_PWY-6074-1_cofactor-92f48b2853d5_69b45718f905	SGD:S000001049	pathwaymech:has_cofactor	CHEBI:30413	biolink:Association	infores:pathwaymech	knowledge_assertion	manual_validation_of_automated_agent	UniProtKB:P10614	UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:24613931)	"[{""reference_id"": ""UniProtKB:P10614"", ""source_assertion"": ""UniProtKB:P10614 annotates CHEBI:30413 as a cofactor of this protein."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/308/comments/0/cofactors/0""}, {""reference_id"": ""UniProtKB:P10614"", ""source_assertion"": ""UniProtKB:P10614 has the exact SGD cross-reference SGD:S000001049."", ""source_locator"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/308/uniProtKBCrossReferences/0""}]"	"[{""id"": ""UniProtKB:P10614"", ""source_sha256"": ""95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d"", ""source_version"": ""UniProt release 2026_03"", ""title"": ""Reviewed UniProtKB P10614 location annotations"", ""url"": ""https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id""}]"	""